title: Complete genome sequence of Newcastle disease virus mesogenic vaccine strain R2B from India.
abstract: Mesogenic vaccine strains of Newcastle disease virus (NDV) are widely used in many countries of Asia and Africa to control the Newcastle disease of poultry. In India, the mesogenic strain R2B was introduced in 1945; it protects adult chickens that have been preimmunized with a lentogenic vaccine virus and provides long-lasting immunity. In this article, we report the complete genome sequence of the hitherto unsequenced Indian vaccine virus strain R2B. The viral genome is 15,186 nucleotides in length and contains the polybasic amino acid motif in the fusion protein cleavage site, indicating that this vaccine strain has evolved from a virulent virus. Phylogenetic analysis of this mesogenic vaccine virus classified it with the viruses belonging to genotype III of the class cluster II of NDV.
authors.affiliation: Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India. sohinimadhan@yahoo.com
authors.forename: Madhan Mohan
authors.initials: MM
authors.lastname: Chellappa
authors.forename: Sohini
authors.initials: S
authors.lastname: Dey
authors.forename: Satish
authors.initials: S
authors.lastname: Gaikwad
authors.forename: J M
authors.initials: JM
authors.lastname: Kataria
authors.forename: V N
authors.initials: VN
authors.lastname: Vakharia
mesh_terms: D000818:Animals; D016679:Genome, Viral; D007194:India; D008969:Molecular Sequence Data; D009521:Newcastle Disease / Q000517:prevention & control; D009522:Newcastle disease virus / Q000235:genetics*; D014765:Viral Vaccines / Q000235:genetics*
chemical_list: D014765:Viral Vaccines