title: [Analysis of cytomegaloviral antigenemia test and re-test after antiviral chemotherapy in patients with autoimmune and non-autoimmune diseases].
abstract: OBJECTIVE
  To retrospectively analyze the cytomegalovirus (CMV) antigenemia test and re-test after antiviral chemotherapy in patients with autoimmune and non-autoimmune diseases.
  
  
  METHODS
  CMV Brite kit and indirect immunofluorescence were used to detect CMVpp65 antigenemia in 6471 peripheral blood leukocyte specimens from 5325 clinic and hospitalized patients with clinically suspicious CMV infections from May 2008 to February 2012. And the positive results were defined as episodes of systemic CMV activity.
  
  
  RESULTS
  In 6471 EDTA-treated peripheral blood specimens, 948 (14.6%) were found with positive CMV antigenemia. The average positive rate from 13 kinds of autoimmune diseases was 34.9% (670/1922) in which systemic lupus erythematosus patients had the highest (52.4%, 551/1052). Meanwhile, the average positive rate from 12 kinds of non-autoimmune diseases was only 6.1% (144/2367) in which it was 17.3% (27/156) in patients with respiratory/acute renal failure, acquired immunodeficiency syndrome (AIDS) and kidney transplant recipients. And 189 patients with positive antigenemia were re-tested after antiviral chemotherapy and only 64 (33.9%) were converted negatively.
  
  
  CONCLUSIONS
  Patients with autoimmune diseases have replaced traditionally immunocompromised patients, e.g. AIDS and kidney transplant recipient, to become the highest risk group of systemic CMV activity. Negative conversion rate of CMV antigenemia is low after antiviral chemotherapy.
authors.affiliation: Department of Clinical Laboratories, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Jing-tao
authors.initials: JT
authors.lastname: Cui
authors.forename: An-ping
authors.initials: AP
authors.lastname: Ni
authors.forename: Ye-li
authors.initials: YL
authors.lastname: Wu
authors.forename: Ling-jun
authors.initials: LJ
authors.lastname: Kong
authors.forename: Wen-juan
authors.initials: WJ
authors.lastname: Yan
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Ya-ling
authors.initials: YL
authors.lastname: Dou
authors.forename: Lan-lan
authors.initials: LL
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000956:Antigens, Viral / Q000097:blood*; D000998:Antiviral Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000956:Antigens, Viral; D000998:Antiviral Agents