title: Stromal cell-derived factor-1α as a novel biomarker for hyperlipidemia.
abstract: Stromal cell-derived factor-1 (SDF-1) is expressed in a wide variety of organs, such as heart, and plays a pivotal role in the mobilization of hematopoietic stem and progenitor cells in bone marrow. SDF-1α, a common subtype of SDF-1, may control hematopoiesis and angiogenesis, but its role in the pathogenesis of hyperlipidemia is unknown. The aim of this study was to determine the role of SDF-1α in the pathogenesis of hyperlipidemia. First, log-transformed SDF-1α serum levels (logSDF-1α) were significantly higher in male patients with borderline high lipid profile (BHLP; n=28; 2.15±0.08 ng/ml) compared to control subjects (n=37; 1.94±0.06 ng/ml; P<0.01). The logSDF-1α in male patients with high lipid profile (HLP; n=33; 1.95±0.08 ng/ml) were lower than BHLP patients (P<0.01). The logSDF-1α was positively associated with HDL-C only in female patients (n=125; r=0.379, P=0.016). These results suggest the different pathophysiology in male and female patients with hyperlipidemia. Moreover, flow cytometry analysis showed that expression of the SDF-1α receptor, CXC-chemokine receptor 4, was lower in peripheral blood mononuclear cells of patients with BHLP (n=10) and HLP (n=10), compared to control subjects (n=10; P<0.001). Lastly, peripheral blood leukocyte, neutrophil and lymphocyte counts were higher in BHLP patients (n=62; P<0.05). Taken together, we suggest SDF-1α as a biomarker of hyperlipidemia that may be helpful to uncover the pathogenesis of hyperlipidemia.
authors.affiliation: Capital Medical University School of Rehabilitation Medicine, and Department of Cardiovasology, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing, PR China. shoulin63@yahoo.com.cn
authors.forename: Shou-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhi-Chang
authors.initials: ZC
authors.lastname: Zheng
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Fu
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Wang
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Chen
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Feng
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D054377:Chemokine CXCL12 / Q000097:blood*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology; D007964:Leukocytosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D019718:Receptors, CXCR4 / Q000097:blood; D012737:Sex Factors; D017154:Stromal Cells / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D054377:Chemokine CXCL12; D019718:Receptors, CXCR4