title: [Intestine dysbiosis and atopic dermatitis in young children].
abstract: OBJECTIVE
  Study the intensity of anti-endotoxin response in intestine of children with atopical dermatitis and intestine dysbioses.
  
  
  METHODS
  110 children with atopic dermatitis of various localization were examined in an outpatient setting. Besides detection of dysbiotic disorders in intestine by using bacteriological seeding on differential-diagnostic media and criteria of evaluation of degree of micro-ecological disorders according to Industry standard of Ministry of Health of Russian Federation "Protocol of patient management. Intestine dysbacteriosis" (2003), content of antibodies against LPS of enterobacteria belonging to various immunoglobulin classes (IgG, IgA, IgM, IgE) by EIA was studied in coprofiltrates.
  
  
  RESULTS
  An increase of content of various immunoglobulins, specific LPS of enterobacteria that depended on the degree of intensity of dysbiotic disorders was detected in children. Allergization in children correlated with an increase of level of anti-endotoxin IgE and IgM (0.8 +/- 0.2) and decrease of IgA content in intestine (-0.8 +/- 0.2). The higher the level of serum anti-LPS antibodies, the more frequently allergic manifestation occur in children.
  
  
  CONCLUSIONS
  Correlation between the level of anti-endotoxin serum IgE and frequency of occurrence of allergic manifestations in children was shown.
authors.forename: A V
authors.initials: AV
authors.lastname: Aleshukina
mesh_terms: D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology* / Q000382:microbiology; D004755:Enterobacteriaceae / Q000276:immunology*; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D005260:Female; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007136:Immunoglobulins / Q000097:blood* / Q000276:immunology; D007223:Infant; D007231:Infant, Newborn; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D017410:Practice Guidelines as Topic
chemical_list: D007070:Immunoglobulin A; D007136:Immunoglobulins; D008070:Lipopolysaccharides; C042866:antilipopolysaccharide antibodies; D007073:Immunoglobulin E