title: Rapid whole-genome sequencing for investigation of a suspected tuberculosis outbreak.
abstract: Two Southeast Asian students attending the same school in the United Kingdom presented with pulmonary tuberculosis. An epidemiological investigation failed to link the two cases, and drug resistance profiles of the Mycobacterium tuberculosis isolates were discrepant. Whole-genome sequencing of the isolates found them to be genetically identical, suggesting a missed transmission event.
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, United Kingdom. estee.torok@addenbrookes.nhs.uk
authors.forename: M Estée
authors.initials: ME
authors.lastname: Török
authors.forename: Sandra
authors.initials: S
authors.lastname: Reuter
authors.forename: Josephine
authors.initials: J
authors.lastname: Bryant
authors.forename: Claudio U
authors.initials: CU
authors.lastname: Köser
authors.forename: Sian V
authors.initials: SV
authors.lastname: Stinchcombe
authors.forename: Bernadette
authors.initials: B
authors.lastname: Nazareth
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Ellington
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Bentley
authors.forename: Geoffrey P
authors.initials: GP
authors.lastname: Smith
authors.forename: Julian
authors.initials: J
authors.lastname: Parkhill
authors.forename: Sharon J
authors.initials: SJ
authors.lastname: Peacock
mesh_terms: D000328:Adult; D004196:Disease Outbreaks; D016680:Genome, Bacterial; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014376:Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology* / Q000635:transmission; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult