title: First case of Bartonella quintana endocarditis in Korea.
abstract: Since microbial gene sequencing was utilized for etiologic diagnosis of culture-negative endocarditis, cases of Bartonella endocarditis have been reported in various countries. Herein we report the first case of Bartonella quintana endocarditis, which was confirmed for the first time in Korea by 16S rRNA gene sequencing from the excised valve. A 75-yr-old woman was hospitalized due to dyspnea. Echocardiography demonstrated large oscillating vegetation at the aortic valve. Blood culture was negative. She underwent valve replacement and sequencing of the 16S rRNA gene from excised valve identified Bartonella quintana. She was successfully treated with combined use of ceftriaxone and gentamicin.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Min Hee
authors.initials: MH
authors.lastname: Lim
authors.forename: Doo Ryeon
authors.initials: DR
authors.lastname: Chung
authors.forename: Wook-Sung
authors.initials: WS
authors.lastname: Kim
authors.forename: Kyung Sun
authors.initials: KS
authors.lastname: Park
authors.forename: Chang-Seok
authors.initials: CS
authors.lastname: Ki
authors.forename: Nam Yong
authors.initials: NY
authors.lastname: Lee
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Kim
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001021:Aortic Valve / Q000473:pathology; D018413:Bartonella quintana / Q000235:genetics / Q000302:isolation & purification*; D002443:Ceftriaxone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004417:Dyspnea / Q000209:etiology; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D056910:Republic of Korea; D017423:Sequence Analysis, RNA
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D012336:RNA, Ribosomal, 16S; D002443:Ceftriaxone