title: Clinical utility of transarterial infusion chemotherapy using cisplatin-lipiodol emulsion for unresectable hepatocellular carcinoma.
abstract: BACKGROUND
  We evaluated the clinical efficacy of transarterial infusion chemotherapy using a cisplatin-lipiodol emulsion for unresectable hepatocellular carcinoma (HCC).
  
  
  METHODS
  Fifty-seven patients with advanced HCC, with no indications for surgical resection or local ablative therapy, such as percutaneous ethanol injection and radiofrequency ablation, were enrolled in this retrospective study.
  
  
  RESULTS
  Twelve patients were treated with cisplatin-alone at a dose of 65 mg/m(2) by infusion into the artery. Forty-two patients were treated with the same dose of cisplatin suspended in 1-10 ml of lipiodol (C/LPD). Cumulative survival rates in the cisplatin-treated group were 46.2% at one year, and 18.5% at two years, whereas these in the C/LPD group were 81.6% and 44.4%, respectively, with a significant difference between the two groups (p<0.01). In the cisplatin-treated group (n=13), no (0%) patients had a complete response (CR), two (15%) a partial response (PR), three (23%) no change (NC), and eight (62%) progressive disease (PD). In the C/LPD group (n=44), four (9%) patients had CR, 16 (35%) PR, 12 (26%) NC, and 12 (26%) PD. CR and PR were seen in 15% of the cisplatin-treated group and in 44% of the C/LPD group. C/LPD was significantly more effective than cisplatin-alone (p=0.039). Some patients showed tumor response to C/LPD after intra-arterial infusion of low-dose 5-fluorouracil.
  
  
  CONCLUSIONS
  C/LPD produced superior effects compared to cisplatin-alone for unresectable HCC, causing no major side-effects, and increasing the survival rate.
authors.affiliation: Department of Gastroenterology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Beppu
authors.forename: Kazushi
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authors.lastname: Sugimoto
authors.forename: Katsuya
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authors.lastname: Shiraki
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tameda
authors.forename: Yuji
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authors.lastname: Inagaki
authors.forename: Suguru
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authors.lastname: Ogura
authors.forename: Chika
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authors.lastname: Kasai
authors.forename: Satoko
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authors.lastname: Kusagawa
authors.forename: Keiichiro
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authors.lastname: Nojiri
authors.forename: Misao
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authors.lastname: Yoneda
authors.forename: Hiroyuki
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authors.lastname: Fuke
authors.forename: Norihiko
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authors.lastname: Yamamoto
authors.forename: Yoshiyuki
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authors.lastname: Takei
authors.forename: Masashi
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authors.lastname: Fujimori
authors.forename: Takaaki
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authors.lastname: Hasegawa
authors.forename: Takashi
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authors.lastname: Yamanaka
authors.forename: Junichi
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authors.lastname: Uraki
authors.forename: Masataka
authors.initials: M
authors.lastname: Kashima
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Takaki
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Nakatsuka
authors.forename: Koichiro
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authors.lastname: Yamakado
authors.forename: Kan
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authors.lastname: Takeda
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage*; D004655:Emulsions / Q000008:administration & dosage; D004998:Ethiodized Oil / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D004655:Emulsions; D004998:Ethiodized Oil; D002945:Cisplatin