title: Determination of total leachable bisphenol A from polysulfone membranes based on multiple consecutive extractions.
abstract: The paper presents the development of a multiple consecutive extraction method enabling the determination of the total amount of bisphenol A (BPA) released from porous polysulfone (PS) membranes in a hemodialyzer or hemoconcentrator under simulated-use conditions. The levels of BPA were determined using solid phase extraction (SPE) coupled with high performance liquid chromatography-mass spectrometry (HPLC-MS). We demonstrated that it was difficult to determine the total amount of BPA released from the PS membranes using a single extraction method with finite solvent volume because of the chemical equilibrium between the extraction solution and the polymer phase. Repeated extractions gave more accurate results than a single extraction for the determination of the total amount of leachables in porous membranes. A general equation was derived to fit the elution profile of BPA released during multiple consecutive extractions.
authors.affiliation: U.S. Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, MD 20993, USA. seungil.cho@fda.hhs.gov
authors.forename: Seungil
authors.initials: S
authors.lastname: Cho
authors.forename: Yong Soo
authors.initials: YS
authors.lastname: Choi
authors.forename: Hoan My-Do
authors.initials: HM
authors.lastname: Luu
authors.forename: Ji
authors.initials: J
authors.lastname: Guo
mesh_terms: D001559:Benzhydryl Compounds / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D013058:Mass Spectrometry; D008567:Membranes, Artificial; D010636:Phenols / Q000032:analysis*; D011108:Polymers / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D008567:Membranes, Artificial; D010636:Phenols; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; C006780:bisphenol A; D000098826:Bisphenol A Compounds