title: [Olfactory ensheathing cell tumour: case report and literature review].
abstract: Olfactory ensheathing cells are glial cells located in the olfactory bulb and nerve. Microscopically, both olfactory ensheathing cells and Schwann cells have similar morphological and immunohistochemical features. However, olfactory ensheathing cells are negative for Leu-7(CD-57), whereas Schwann cells are positive. We present the case of a 49 year-old male with a history of visual impairment and hyposmia. Radiological CT and MRI studies showed a subfrontal cystic extra-axial mass, which eroded the right cribriform plate, with heterogeneous contrast enhancement. Total excision of the tumour was performed by bifrontal craniotomy. Histological examination initially suggested a schwannoma, with immunohistochemical staining being positive for S-100 protein and negative for epithelial membrane antigen (EMA). However, the tumour was negative for Leu-7. Accordingly, the final diagnosis was olfactory ensheathing cell tumour. Herein, we describe the sixth case of intracranial olfactory ensheathing cell tumour and stress the important role of immunohistochemical techniques in obtaining a definitive diagnosis.
authors.affiliation: Servicio de Neurocirugía, Complejo Hospitalario de Jaén, Jaén, España. Electronic address: rajabal@comz.org.
authors.forename: Rajab
authors.initials: R
authors.lastname: Al-Ghanem
authors.forename: Francisco Manuel
authors.initials: FM
authors.lastname: Ramos-Pleguezuelos
authors.forename: Sandra Irene
authors.initials: SI
authors.lastname: Pérez-Darosa
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Galicia-Bulnes
authors.forename: Francisco
authors.initials: F
authors.lastname: Cabrerizo-Carvajal
authors.forename: Osamah Abdullah
authors.initials: OA
authors.lastname: El-Rubaidi
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D018959:CD57 Antigens / Q000032:analysis; D003390:Cranial Nerve Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003399:Craniotomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D018317:Nerve Sheath Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009442:Neurilemmoma / Q000737:chemistry / Q000473:pathology; D000857:Olfaction Disorders / Q000209:etiology; D009832:Olfactory Nerve / Q000737:chemistry / Q000473:pathology*; D020431:Olfactory Nerve Diseases / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis; D014786:Vision Disorders / Q000209:etiology
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018959:CD57 Antigens; D018396:Mucin-1; D009418:S100 Proteins