title: A pure invasive cribriform carcinoma of the breast with bone metastasis if untreated for thirteen years: a case report and literature review.
abstract: We report a case of pure invasive cribriform carcinoma of the breast, which had been untreated for thirteen years, being found with bone metastasis at initial presentation, because distant metastasis is rarely found in this tumor. A fifty-nine-year-old postmenopausal woman presented with a large left breast mass. Although she had noticed a lump in a left breast thirteen years ago, she had not sought treatment. The tumor had enlarged gradually since from one year before and become ulcerated. The two enlarged axillary lymph nodes were also palpable. After two cycles of neoadjuvant chemotherapy, she underwent left radial mastectomy with a free skin graft. Emission computed tomography result has confirmed bone metastasis. The histological diagnosis of the tumor revealed the pure invasive cribriform carcinoma, since over than ninety percent of invasive tumor components showed a characteristic cribriform growth, and the remainder was tubular carcinoma. She has been well without evidence of tumor recurrence for seven years after surgery and several routine postoperative therapies. Although with favorable prognosis, pure invasive cribriform carcinoma is still possible to develop into the advanced (Stage four) breast cancer if untreated for a long time. However, the survival of this patient for free disease after several locoregional and systemic therapies maybe provide a supplement for invasive cribriform carcinoma's excellent prognosis.
authors.affiliation: Breast Pathology Department and Laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key laboratory of Cancer Prevention and Therapy of Tianjin, West Huanhu Road, Ti Yuan Bei, Hexi District, Tianjin 300060, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Zhichun
authors.initials: Z
authors.lastname: Lin
authors.forename: Tongxian
authors.initials: T
authors.lastname: Zhang
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Niu
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013997:Time Factors; D014055:Tomography, Emission-Computed