title: [Low-manifest infections in children and adolescents with consequences of perinatal damage of nervous system].
abstract: OBJECTIVE
  Study the specter of low-manifest infections (LMI) and their role in children and adolescents with diseases of central nervous system (CNS) against the background of consequences of perinatal damage of nervous system (PDNS).
  
  
  METHODS
  Infectologic and neurologic examinations were carried out in 42 patients with consequences of PDNS (17 girls and 25 boys, 3 - 15 years). Detection of LMI resulted in etiotropic therapy with evaluation of clinical and laboratory data in dynamics.
  
  
  RESULTS
  In 93% (39/42) of patients causative agents of LMI were diagnosed in various combinations and in various biological materials. Among those: Chlamydia spp.--in 71% of patients, Mycoplasma spp.--in 31%, Ureaplasma urealyticum--in 14% (in total the listed microorganisms were diagnosed in 83% of patients); Herpesviridae family viruses--in 75% (HHV-6--in 67%, VEB--in 36%, CMV--in 11%, HSV-1,2--in 11%). Combination of Chlamydia spp. with HHV-6 (R tetr = +0.61) and with VEB (R tet = +0.74) (P < 0.05) was detected. None of the patients had typical signs of encephalitis clinically or based on MRT. MRT signs of gliosis-atrophic changes in the CNS were detected in all the patients. Reduction of a number of psycho-neurologic and neurologic syndromes was noted in all the patients during LMI therapy.
  
  
  CONCLUSIONS
  Most of the patients with consequences of PDNS had low-intensity inflammatory-degenerative process in the CNS determined by LMI, first of all by Chlamydia spp. as well as Mycoplasma spp.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Vaĭnshenker
authors.forename: O V
authors.initials: OV
authors.lastname: Kalinina
authors.forename: I V
authors.initials: IV
authors.lastname: Nuralova
authors.forename: I M
authors.initials: IM
authors.lastname: Ivchenko
authors.forename: L A
authors.initials: LA
authors.lastname: Meliucheva
authors.forename: V A
authors.initials: VA
authors.lastname: Tsinzerling
mesh_terms: D000293:Adolescent; D001925:Brain Damage, Chronic / Q000209:etiology* / Q000382:microbiology / Q000821:virology; D002490:Central Nervous System / Q000382:microbiology* / Q000473:pathology / Q000821:virology; D020806:Central Nervous System Bacterial Infections / Q000150:complications / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D002689:Chlamydia / Q000502:physiology; D002908:Chronic Disease; D060085:Coinfection; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000150:complications* / Q000382:microbiology; D006564:Herpesviridae / Q000502:physiology; D006566:Herpesviridae Infections / Q000150:complications* / Q000821:virology; D006801:Humans; D008297:Male; D009174:Mycoplasma / Q000502:physiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D012720:Severity of Illness Index; D016990:Ureaplasma urealyticum / Q000502:physiology