title: Chronic exposure to low concentrations of strontium 90 affects bone physiology but not the hematopoietic system in mice.
abstract: The aim of this work was to delineate the effects of chronic ingestion of strontium 90 ((90) Sr) at low concentrations on the hematopoiesis and the bone physiology. A mouse model was used for that purpose. Parent animals ingested water containing 20 kBq l(-1) of (90) Sr two weeks before mating. Offspring were then continuously contaminated with (90) Sr through placental transfer during fetal life, through lactation after birth and through drinking water after weaning. At various ages between birth and 20 weeks, animals were tested for hematopoietic parameters such as blood cell counts, colony forming cells in spleen and bone marrow and cytokine concentrations in the plasma. However, we did not find any modification in (90) Sr ingesting animals as compared with control animals. By contrast, the analysis of bone physiology showed a modification of gene expression towards bone resorption. This was confirmed by an increase in C-telopeptide of collagen in the plasma of (90) Sr ingesting animals as compared with control animals. This modification in bone metabolism was not linked to a modification of the phosphocalcic homeostasis, as measured by calcium, phosphorus, vitamin D and parathyroid hormone in the blood. Overall these results suggest that the chronic ingestion of (90) Sr at low concentration in the long term may induce modifications in bone metabolism but not in hematopoiesis.
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, PRP-HOM/SRBE, LRTOX, Fontenay-aux-roses, France.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Synhaeve
authors.forename: Ndéye Marième
authors.initials: NM
authors.lastname: Wade-Gueye
authors.forename: Stefania
authors.initials: S
authors.lastname: Musilli
authors.forename: Johanna
authors.initials: J
authors.lastname: Stefani
authors.forename: Line
authors.initials: L
authors.lastname: Grandcolas
authors.forename: Gaëtan
authors.initials: G
authors.lastname: Gruel
authors.forename: Maâmar
authors.initials: M
authors.lastname: Souidi
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dublineau
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Bertho
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001854:Bone Marrow Cells / Q000187:drug effects / Q000378:metabolism; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000097:blood; D024042:Collagen Type I / Q000097:blood; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005786:Gene Expression Regulation; D006413:Hematopoietic System / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000097:blood; D010641:Phenotype; D010758:Phosphorus / Q000097:blood; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013324:Strontium / Q000008:administration & dosage* / Q000633:toxicity*; D014807:Vitamin D / Q000097:blood
chemical_list: D024042:Collagen Type I; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D014807:Vitamin D; D010758:Phosphorus; D002118:Calcium; D013324:Strontium