title: Synthesis of ortho-acylphenols through the palladium-catalyzed ketone-directed hydroxylation of arenes.
abstract: Ketone in charge: a formal ketone-directed palladium-catalyzed ortho-hydroxylation of arenes has been developed as an effective approach to access o-acylphenols from simple arylketones. A Pd-catalyzed oxidative ortho-carbonylation reaction using ketone directing groups to access a ketal-lactone motif is also demonstrated. The ubiquity and versatile nature of ketones make these methods attractive. BTI=PhI(TFA)(2); DCE=1,2-dichloroethane.
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Austin, 78712, USA.
authors.forename: Fanyang
authors.initials: F
authors.lastname: Mo
authors.forename: Louis J
authors.initials: LJ
authors.lastname: Trzepkowski
authors.forename: Guangbin
authors.initials: G
authors.lastname: Dong
mesh_terms: D002384:Catalysis; D006900:Hydroxylation; D007659:Ketones / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D007659:Ketones; D007783:Lactones; D010636:Phenols; D010165:Palladium