title: TLRs and IFNs: critical pieces of the autoimmunity puzzle.
abstract: Discoveries revealing the molecular basis of innate immune responses, particularly the identification of Toll-like receptors (TLRs) as the major recognition sensors for microbial and even self-molecules, have provided new insights into the pathogenesis of both systemic and organ-specific autoimmune diseases. These insights will permit the development of novel treatment modalities for these disorders.
authors.affiliation: Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, California 92037, USA. argyrio@scripps.edu
authors.forename: Argyrios N
authors.initials: AN
authors.lastname: Theofilopoulos
mesh_terms: D000818:Animals; D020296:Animals, Congenic; D000974:Antibodies, Antinuclear / Q000276:immunology; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D004195:Disease Models, Animal; D011992:Endosomes / Q000276:immunology; D005260:Female; D006801:Humans; D007372:Interferons / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009696:Nucleic Acids / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; D007519:Isoantigens; D009696:Nucleic Acids; D051193:Toll-Like Receptors; D007372:Interferons