title: How to maintain patients on long-term therapy: understanding the profile and kinetics of adverse events.
abstract: Thalidomide, lenalidomide, and bortezomib have considerably improved the survival of patients with multiple myeloma. These agents have specific adverse event (AE) profiles, and it is especially important to consider severe AEs that may lead to premature discontinuation, negatively affecting outcomes. AEs of particular concern are peripheral neuropathy (associated with thalidomide and bortezomib), venous thromboembolism (associated with thalidomide and lenalidomide), and myelosuppression (associated with lenalidomide and bortezomib). AEs are usually predictable and easily managed with monitoring, appropriate dose adjustments, and supportive care. AEs are generally transient, occurring early in the course of treatment, providing evidence for the feasibility of continuous therapy.
authors.affiliation: Hematology Department, University Hospital of Salamanca, Salamanca, Spain. mvmateos@usal.es
authors.forename: María-Victoria
authors.initials: MV
authors.lastname: Mateos
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001897:Boronic Acids / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D000069286:Bortezomib; D032882:Comprehension; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D000077269:Lenalidomide; D060046:Maintenance Chemotherapy / Q000009:adverse effects / Q000706:statistics & numerical data; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism; D011719:Pyrazines / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D013997:Time Factors
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D013792:Thalidomide; D000069286:Bortezomib; D000077269:Lenalidomide