title: Prognostic factors of unresectable pancreatic cancer treated with nafamostat mesilate combined with gemcitabine chemotherapy.
abstract: BACKGROUND
  The aim of this study was to investigate prognostic factors of survival for patients with unresectable pancreatic cancer treated with nafamostat mesilate combined with gemcitabine chemotherapy.
  
  
  METHODS
  The study included 41 patients who were diagnosed with unresectable pancreatic cancer and eligible for our clinical study of nafamostat mesilate, combined with gemcitabine chemotherapy for unresectable pancreatic cancer between February 2007 and November 2010 at Jikei University Hospital. We retrospectively investigated the relation between patients' characteristics and overall survival using univariate and multivariate analyses.
  
  
  RESULTS
  In univariate analysis, absence of jaundice (p=0.0365), presence of ascites with or without histological diagnosis of carcinomatosis (p=0.0042), lymphocyte count ≥2,000/μl (p=0.0088), serum C-reactive protein ≥1 mg/dl (p=0.014), serum carcinoembryonic antigen ≥5 ng/ml (p=0.0064) and serum CA19-9 ≥500 U/ml (p=0.0164) were significant predictors of poor overall survival. In multivariate analysis, absence of jaundice (p=0.0057), presence of ascites with or without histological diagnosis of carcinomatosis (p=0.0326), lymphocyte ≥2,000/μl (p<0.0001) and CA19-9 ≥500 U/ml (p=0.0198) were independent predictors.
  
  
  CONCLUSIONS
  Jaundice, ascites, high lymphocyte count and high serum CA19-9 levels are independent prognostic predictors for poor overall survival of patients with unresectable pancreatic cancer treated with nafamostat mesilate combined with gemcitabine chemotherapy.
authors.affiliation: Department of Surgery, Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. k-furukawa@jikei.ac.jp
authors.forename: Kenei
authors.initials: K
authors.lastname: Furukawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Uwagawa
authors.forename: Ryota
authors.initials: R
authors.lastname: Iwase
authors.forename: Koichiro
authors.initials: K
authors.lastname: Haruki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Gocho
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shiba
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Misawa
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yanaga
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001550:Benzamidines; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D006146:Guanidines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D016019:Survival Analysis; D000093542:Gemcitabine
chemical_list: D001550:Benzamidines; D006146:Guanidines; D003841:Deoxycytidine; C032855:nafamostat; D000093542:Gemcitabine