title: Meta-analysis of the relation between the VDR gene TaqIpolymorphism and genetic susceptibility to prostate cancer in Asian populations.
abstract: BACKGROUND
  Polymorphisms of the Taq I gene have been associated with prostate cancer risk.
  
  
  METHODS
  We applied a fixed-effects model to combine odds ratios (ORs) and 95% confidence intervals (95% CI). The Egger's test was carried out to evaluate potential publication bias.
  
  
  RESULTS
  A total of 10 case-control studies enrolling 1,141 prostate cancer patients and 1,685 controls were included in this meta-analysis. Compared with the T allele, the OR for the C allele was 0.81 (0.70-0.94). The ORs for CT and CC+CT genotypes were 0.86 (0.74-1.01) and 0.84 (0.73-0.97) compared to wide type genotype (homozygote TT).
  
  
  CONCLUSIONS
  The present meta-analysis suggests that the TF gene Taq I polymorphism may reduce the prostate cancer risk in Asian populations.
authors.affiliation: College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu, Sichuan, China.
authors.forename: Ya-Jie
authors.initials: YJ
authors.lastname: Guo
authors.forename: Ze-Ming
authors.initials: ZM
authors.lastname: Shi
authors.forename: Jun-Da
authors.initials: JD
authors.lastname: Liu
authors.forename: Ning
authors.initials: N
authors.lastname: Lei
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Tang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human