title: Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition.
abstract: The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-loaded P-MSNs by improving cell killing.
authors.affiliation: Department of Microbiology, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.
authors.forename: Rolando E
authors.initials: RE
authors.lastname: Yanes
authors.forename: Derrick
authors.initials: D
authors.lastname: Tarn
authors.forename: Angela A
authors.initials: AA
authors.lastname: Hwang
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Ferris
authors.forename: Sean P
authors.initials: SP
authors.lastname: Sherman
authors.forename: Courtney R
authors.initials: CR
authors.lastname: Thomas
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.forename: April D
authors.initials: AD
authors.lastname: Pyle
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Zink
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Tamanoi
mesh_terms: D002460:Cell Line; D004337:Drug Carriers / Q000737:chemistry*; D005089:Exocytosis / Q000502:physiology; D006801:Humans; D008247:Lysosomes / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D012822:Silicon Dioxide