title: [Similarity of cycloprolylglycine to piracetam in antihypoxic and neuroprotective effects].
abstract: The antihypoxic activity of the endogenous cyclic dipeptide cycloprolylglycine (CPG) has been studied on a model of normobaric hypoxia with hypercapnia and its neuroprotective activity has been studied on a model of human neuroblastoma SH-SY5Y cell damage by 6-hydroxydopamine. It is established that CPG exhibits the antihypoxic activity at doses of 0.5 and 1.0 mg/kg (i.p.) on outbred and BALB/c mice, but not on C57B1/6 mice. The neuroprotective activity of CPG was detected in 10(-5) - 10(-8) M concentration range only when the treatment was carried out 24h before toxin introduction. The obtained data confirm the hypothesis that piracetam is a mimetic of the endogenous CPG neuropeptide.
authors.forename: K N
authors.initials: KN
authors.lastname: Kolisnikova
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: G A
authors.initials: GA
authors.lastname: Nazarova
authors.forename: T A
authors.initials: TA
authors.lastname: Antipov
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006935:Hypercapnia / Q000139:chemically induced / Q000517:prevention & control*; D000860:Hypoxia / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016627:Oxidopamine / Q000009:adverse effects / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology*; D013565:Sympatholytics / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D018696:Neuroprotective Agents; D010456:Peptides, Cyclic; D013565:Sympatholytics; D016627:Oxidopamine; C062238:cyclo(prolylglycyl); D010889:Piracetam