title: Genome-wide identification and evolutionary analysis of B7-H3.
abstract: B7-H3 is an immune co-stimulatory molecule of the B7 family that contains a set of immunoglobulin-V (IgV) and immunoglobulin-C (IgC) domains. To explore the evolutionary process of B7-H3 gene, we conducted a genome-wide structure and phylogenetic analysis of B7-H3 genes in currently sequenced genomes. On the basis of the available data, 17 mammalian B7-H3 genes were predicted to have tandemly duplicated 4Ig domains. The analysis of gene structure and phylogenesis reveal that these 4IgB7-H3 genes resulted from domain duplication. Nevertheless, no difference in function has been observed between the two isoforms. It is more likely that domain duplication in 4IgB7-H3 leads to functional redundancy.
authors.affiliation: Center for System Biology, Soochow University, Suzhou 215006, China. Melissa.duan@hotmail.com
authors.forename: Hairong
authors.initials: H
authors.lastname: Duan
authors.forename: Moli
authors.initials: M
authors.lastname: Huang
mesh_terms: D000818:Animals; D060887:B7 Antigens / Q000235:genetics*; D005075:Biological Evolution; D016678:Genome; D023281:Genomics / Q000379:methods*; D006801:Humans; D010802:Phylogeny; D020033:Protein Isoforms / Q000235:genetics
chemical_list: D060887:B7 Antigens; D020033:Protein Isoforms