title: Stromal CEACAM1 expression regulates colorectal cancer metastasis.
abstract: Colorectal cancer metastasis to Ceacam1-/- livers is significantly impaired, compared with wild type livers, due to decreased endothelial cell survival, reduced tumor cell proliferation, diminished immune infiltration and altered chemokine expression. Ceacam1-/- myeloid-derived suppressor cells diminish metastatic burden, as confirmed by bone marrow transplantation and adoptive transfer experiments.
authors.affiliation: Goodman Cancer Research Centre; McGill University; Montreal, QC Canada.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Arabzadeh
authors.forename: Nicole
authors.initials: N
authors.lastname: Beauchemin