title: The fibrinogen/CRP ratio as a new parameter for the diagnosis of disseminated intravascular coagulation in patients with HELLP syndrome and as a predictive factor for neonatal outcome.
abstract: OBJECTIVE
  The aim of this study was to determine if the fibrinogen/C-reactive protein (CRP) ratio could be used in obstetrics as a predictor for a disseminated intravascular coagulation.
  
  
  METHODS
  One hundred eleven patients with hemolysis, elevated liver enzymes, and low platelet count syndrome at the Department of Obstetrics and Fetomaternal Medicine (General Hospital, Vienna, Austria) were selected and divided into 2 groups (overt disseminated intravascular coagulation, no overt disseminated intravascular coagulation). The classical parameters and the fibrinogen/CRP ratio were compared. The analysis was carried out using IBM SPSS statistical package (SPSS, Inc, Cary, NC).
  
  
  RESULTS
  The fibrinogen/CRP ratio showed significant differences. The receiver-operating characteristic analysis showed for the ratio (area under the curve, 0.74) significantly better discriminative power than for fibrinogen (area under curve, 0.59). The odds ratio for the fibrinogen/CRP ratio was 7.04. Finally, significant correlations between the ratio and the neonatal outcome were found.
  
  
  CONCLUSIONS
  We suggest the implementation of the fibrinogen/CRP ratio within patients with hemolysis, elevated liver enzymes, and low platelet count syndrome as a diagnostic and prognostic factor for the occurrence of disseminated intravascular coagulation.
authors.affiliation: Department of Obstetrics and Fetomaternal Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Karin
authors.initials: K
authors.lastname: Windsperger
authors.forename: Rainer
authors.initials: R
authors.lastname: Lehner
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D017359:HELLP Syndrome / Q000097:blood*; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D005340:Fibrinogen; D002097:C-Reactive Protein