title: Echinohalimane A, a bioactive halimane-type diterpenoid from a Formosan gorgonian Echinomuricea sp. (Plexauridae).
abstract: A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory effect on the release of elastase by human neutrophils. Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria.
authors.affiliation: Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors.forename: Hsu-Ming
authors.initials: HM
authors.lastname: Chung
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Li-Chung
authors.initials: LC
authors.lastname: Hu
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Wei-Hsuan
authors.initials: WH
authors.lastname: Yen
authors.affiliation: Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.affiliation: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
authors.forename: Tsong-Long
authors.identifier: 0000-0002-5780-3977
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.affiliation: Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Ping-Jyun
authors.identifier: 0000-0002-6644-9236
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D003063:Cnidaria / Q000378:metabolism*; D004224:Diterpenes / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; C580810:echinohalimane A; D015107:4-Butyrolactone