title: Candidate gene association study of BMI-related loci, weight, and adiposity in old age.
abstract: Most genome-wide association studies are confined to middle-aged populations. It is unclear whether associations between single nucleotide polymorphisms (SNPs) and obesity persist in old age. We aimed to relate 10 body mass index (BMI)-associated SNPs to weight, BMI, % fat, visceral and subcutaneous adipose tissue in Health ABC and AGES-Reykjavik comprising 4,846 individuals of European Ancestry, and 1,139 African Americans over age 65. SNPs were scaled using effect estimates from candidate SNPs. In Health ABC, a SNP near GNPDA2 was modestly associated with weight and SAT area (p = .008, p = .001). Risk score (sum of scaled SNPs) was associated with weight, BMI, and SAT area (p < .0001 for all), but neither GNPDA2 nor risk score was associated with weight, BMI, visceral adippose tissue, subcutaneous adipose tissue, or % fat in AGES-Reykjavik. In African Americans, a SNP near SEC16B was weakly associated with weight (p = .04). In this sample of older adults, no BMI-associated SNPs were associated with weight or adiposity.
authors.affiliation: Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA. Rachel.murphy@nih.gov
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Murphy
authors.forename: Michael A
authors.initials: MA
authors.lastname: Nalls
authors.forename: Margaux
authors.initials: M
authors.lastname: Keller
authors.forename: Melissa
authors.initials: M
authors.lastname: Garcia
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
authors.forename: Frances A
authors.initials: FA
authors.lastname: Tylavsky
authors.forename: Anne B
authors.initials: AB
authors.lastname: Newman
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Tranah
authors.forename: Gudny
authors.initials: G
authors.lastname: Eiriksdottir
authors.forename: Vilmundur
authors.initials: V
authors.lastname: Gudnason
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
mesh_terms: D050154:Adiposity / Q000235:genetics*; D001741:Black or African American / Q000208:ethnology / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D005786:Gene Expression Regulation; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D050177:Overweight / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012494:Sampling Studies; D014481:United States / Q000453:epidemiology; D044465:White People / Q000208:ethnology / Q000235:genetics*