title: High signal contrast gating with biomodified Gd doped mesoporous nanoparticles.
abstract: Internally Gd doped mesoporous nanoparticles have been prepared and exhibit unprecedented relaxivities that are retained on external biomodification. In tuning diffusive water access, image contrast can be reversibly switched in the presence of a specific protein target.
authors.affiliation: Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QZ, UK.
authors.forename: Wen-Yen
authors.initials: WY
authors.lastname: Huang
authors.forename: Gemma-Louise
authors.initials: GL
authors.lastname: Davies
authors.forename: Jason J
authors.initials: JJ
authors.lastname: Davis
mesh_terms: D005682:Gadolinium / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D016062:Porosity; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D006573:Heterocyclic Compounds, 1-Ring; D011506:Proteins; D014867:Water; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D012822:Silicon Dioxide; D005682:Gadolinium