title: [The impact of early and late ischemic preconditioning on brain damage and degree of neurological deficiency in rats].
abstract: The present study was aimed to investigate neuroprotective effects of early and late ischemic preconditioning in the acute phase of ischemic brain damage in rats. It was found that a single five-minute ischemic episode of early ischemic preconditioning did not lead to significant neuroprotective effects in comparison with control group, while three five-minute ischemic episode early ischemic preconditioning accompanied by a significant increase in neurological deficit and growing damage rate in CA1 hippocampus neurons. In contrast, later ischemic preconditioning in form of single five-minute episode 24 hours before ischemia modeling, provided a significant neuroprotective effect, manifesting reduced neurological deficit and maintaining viability of CA1 hippocampus neurons.
authors.forename: N S
authors.initials: NS
authors.lastname: Shcherbak
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Vyboldina
authors.forename: M M
authors.initials: MM
authors.lastname: Galaguzda
authors.forename: L B
authors.initials: LB
authors.lastname: Mitrofanova
authors.forename: E M
authors.initials: EM
authors.lastname: Nifontov
authors.forename: E R
authors.initials: ER
authors.lastname: Barantsevich
authors.forename: E V
authors.initials: EV
authors.lastname: Shliakhto
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D019194:Ischemic Preconditioning; D008297:Male; D009422:Nervous System Diseases / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors