title: Rhodium-catalyzed regio-, diastereo-, and enantioselective [2+2+2] cycloaddition of 1,6-enynes with acrylamides.
abstract: Ring ring: annulated cyclohexenes were synthesized by using the title reaction with the cationic rhodium(I)/(R)-H(8) -binap complex as a catalyst. In this catalysis, regioselective insertion of the acrylamide into a rhodacyclopentene intermediate and the coordination of the carbonyl group of the acrylamide to the cationic rhodium center suppress the undesired β-hydride elimination.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Masutomi
authors.forename: Norifumi
authors.initials: N
authors.lastname: Sakiyama
authors.forename: Keiichi
authors.initials: K
authors.lastname: Noguchi
authors.forename: Ken
authors.initials: K
authors.lastname: Tanaka