title: [Analysis of prognostic factors of non-small cell lung cancer in patients under 40 years of age].
abstract: OBJECTIVE
  To investigate the prognostic factors for non-small cell lung cancer(NSCLC)in patients under 40 years of age.
  
  
  METHODS
  The clinicopathological data of 148 young patients with NSCLC were retrospectively analyzed. Kaplan-Meier and Cox regression analyses were used to analyze the relationship between prognostic factors and survival time.
  
  
  RESULTS
  The patients were followed-up for 6 - 148 months, and the follow-up rate was 100%. In the whole group, 122 patients died and 26 cases were surviving. The 1-, 3- and 5-year survival rates were 54.7%, 10.4% and 5.6%, respectively. The median survival time (MST) was 14.7 months. Kaplan-Meier analysis showed that Karnofsky performance status (KPS), clinical stage, treatment modality and serum CEA were related with prognosis (P < 0.05). Multivariate analysis indicated that KPS, clinical stage, treatment modality and serum CEA were independent prognostic factors (P < 0.05).
  
  
  CONCLUSIONS
  KPS, CEA, clinical stage and treatment modalities are independent prognostic factors in young NSCLC patients.
authors.affiliation: Department of Respiratory Disease, Nanjing Chest Hospital, Nanjing, China.
authors.forename: Chun-hua
authors.initials: CH
authors.lastname: Xu
authors.forename: Li-ke
authors.initials: LK
authors.lastname: Yu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Xie
authors.forename: Ke-ke
authors.initials: KK
authors.lastname: Hao
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.forename: Ning
authors.initials: N
authors.lastname: Xia
authors.forename: Ping
authors.initials: P
authors.lastname: Zhan
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017567:Karnofsky Performance Status; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000379:methods; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
chemical_list: D002272:Carcinoembryonic Antigen