title: miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6.
abstract: MicroRNAs (miRNA) have emerged as key players in carcinogenesis. Here, we investigated the role of miR-137 in the pathogenesis of lung cancer. The downregulation of miR-137 in lung cancer cells could be rescued following inhibition of DNA methylation. Ectopic expression of miR-137 in lung cancer cells significantly downregulated Cdc42, Cdk6 and induced G1 cell cycle arrest, leading to a significant decrease in cell growth in vivo and in vitro. Further, both Cdc42 and Cdk6 were confirmed as targets of miR-137.
authors.affiliation: The Fourth Affiliated Hospital of Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212000, China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Zhu
authors.forename: Yuefeng
authors.initials: Y
authors.lastname: Li
authors.forename: Huiling
authors.initials: H
authors.lastname: Shen
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Lulu
authors.initials: L
authors.lastname: Long
authors.forename: Lulu
authors.initials: L
authors.lastname: Hui
authors.forename: Wenlin
authors.initials: W
authors.lastname: Xu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D051361:Cyclin-Dependent Kinase 6 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D015254:DNA Modification Methylases / Q000037:antagonists & inhibitors; D015536:Down-Regulation; D016193:G1 Phase / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D018014:Gene Transfer Techniques; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000628:therapy; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays; D020764:cdc42 GTP-Binding Protein / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; C545567:MIRN137 microRNA, human; C551799:MIRN137 microRNA, mouse; D035683:MicroRNAs; D015254:DNA Modification Methylases; C495911:CDK6 protein, human; C495912:Cdk6 protein, mouse; D051361:Cyclin-Dependent Kinase 6; D020764:cdc42 GTP-Binding Protein