title: Reproductive and developmental toxicity screening test of 3-cyanopyridine in rats.
abstract: Crl:CD(SD)rats were given 3-cyanopyridine by gavage at 0, 5, 30 or 180 mg/kg/day. Males were dosed for 42 days beginning 14 days before mating, and females for 40-53 days beginning 14 days before mating to day 3 of lactation, including throughout the mating and gestation periods. General toxicity, mainly liver damage, was observed in males at ≥30 mg/kg/day and in females at ≥5 mg/kg/day. Sertoli cell vacuolation was observed at 180 mg/kg/day, and spermatocyte damages were observed at ≥30 mg/kg/day. Effects on estrous cycles, corpora lutea and implantations, and unsuccessfully mated females, despite additional mating, were observed at 180 mg/kg/day. Delayed initiation of delivery, dystocia, and deaths or moribundities of pregnant females were observed at 180 mg/kg/day, and only two pregnant rats delivered live pups at that dose. The NOAEL for reproductive/developmental toxicity was concluded to be 30 mg/kg/day.
authors.affiliation: Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Takahashi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yabe
authors.forename: Hina
authors.initials: H
authors.lastname: Kato
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kawamura
authors.forename: Mariko
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Mutsuko
authors.initials: M
authors.lastname: Hirata-Koizumi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ono
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hirose
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects / Q000254:growth & development; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011725:Pyridines / Q000633:toxicity*; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects
chemical_list: D011725:Pyridines; C020729:3-cyanopyridine