title: Effect of periodontal therapy on prevention of gastric Helicobacter pylori recurrence: a systematic review and meta-analysis.
abstract: OBJECTIVE
  The aim of this review is to assess the effect of dental plaque control and periodontal therapy on prevention of gastric Helicobacter pylori (H. pylori) recurrence.
  
  
  METHODS
  We conducted searches of electronic databases, and included controlled trials comparing periodontal treatment and eradication therapy of H. pylori with eradication therapy alone for prevention of recurrence of gastric H. pylori. We used the absence of recurrence of gastric H. pylori after the first 3 months as an outcome measure to determine relative risk of persistence of gastric H. pylori. We estimated the degree of heterogeneity among trial results using Q and I(2)  statistics.
  
  
  RESULTS
  Three trials including 298 patients were eligible according to our inclusion criteria. As significant heterogeneity was indicated by the Q statistics (p = 0.04) and I(2)  (69%), we used a random-effects model to combine the data. Compared with eradication therapy alone, the adjunction of periodontal therapy significantly reduced the relative risk of persistence of gastric H. pylori by 63% (0.37 [95% CI 0.21-0.64], p = 0.0004) in patients with gastric diseases.
  
  
  CONCLUSIONS
  The adjunction of periodontal treatment to eradication therapy appears to reduce gastric H. pylori recurrence compared with eradication therapy alone among patients with gastric diseases associated with H. pylori. The results of this meta-analysis should be taken with caution because of the limitations in the primary data.
authors.affiliation: Department of periodontology,Biostatistical, Clinical and Epidemiological Research Laboratory, Mohammed the 5th Souissi University, Rabat, Morocco. amal.bouziane@gmail.com
authors.forename: Amal
authors.initials: A
authors.lastname: Bouziane
authors.forename: Samir
authors.initials: S
authors.lastname: Ahid
authors.forename: Redouane
authors.initials: R
authors.lastname: Abouqal
authors.forename: Oumkeltoum
authors.initials: O
authors.lastname: Ennibi
mesh_terms: D016009:Chi-Square Distribution; D003773:Dental Plaque / Q000628:therapy*; D016481:Helicobacter Infections / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D016013:Likelihood Functions; D009055:Mouth / Q000382:microbiology; D010518:Periodontitis / Q000628:therapy*; D017594:Publication Bias; D055502:Secondary Prevention; D013272:Stomach Diseases / Q000382:microbiology / Q000517:prevention & control*