title: Absence of anatomic corpus callosal abnormalities in childhood-onset schizophrenia patients and healthy siblings.
abstract: The corpus callosum (CC) has been implicated in the pathogenesis of schizophrenia, and CC deficits have been reported in adults with schizophrenia. We explored the developmental trajectory of the corpus callosum in childhood-onset schizophrenia (COS) patients, their healthy siblings (SIB) and healthy volunteers. We obtained 235 anatomic brain magnetic resonance imaging (MRI) scans from 98 COS patients, 153 scans from 71 of their healthy siblings, and 253 scans from 100 age- and gender-matched healthy volunteers, across ages 9-30 years. The volumes of five sub-regions of the CC were calculated using FreeSurfer, and summed to give the total volume. Longitudinal data were examined using mixed model regression analysis. There were no significant differences for the total or sub-regional CC volumes between the three groups. There were also no significant differences between the groups for developmental trajectory (slope) of the CC. This is the largest longitudinal study of CC development in schizophrenia and the first COS study of the CC to include healthy siblings. Overall, CC volume and growth trajectory did not differ between COS patients, healthy siblings, or healthy volunteers. These results suggest that CC development, at least at a macroscopic level, may not be a salient feature of schizophrenia.
authors.affiliation: Child Psychiatry Branch, National Institute of Mental Health, 10/3N202, 10 Center Drive, Bethesda, MD 20892, USA. sarahmetthe@gmail.com
authors.forename: Sarah L M
authors.initials: SL
authors.lastname: Johnson
authors.forename: Deanna
authors.initials: D
authors.lastname: Greenstein
authors.forename: Liv
authors.initials: L
authors.lastname: Clasen
authors.forename: Rachel
authors.initials: R
authors.lastname: Miller
authors.forename: Francois
authors.initials: F
authors.lastname: Lalonde
authors.forename: Judith
authors.initials: J
authors.lastname: Rapoport
authors.forename: Nitin
authors.initials: N
authors.lastname: Gogtay
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D012561:Schizophrenia, Childhood / Q000473:pathology*; D035781:Siblings