title: NK cell-associated antigen expression in retinoblastoma animal model.
abstract: Natural killer (NK) cells are critical components of our immune system. Herein, we for the first time analyzed the expression and localization of the activating receptor NK cell lectin-like receptor gene 2D (NKG2D) ligands, HLA-G, MICA, MICA/B, and ULBP-2 in orthotopic transplantation models of retinoblastoma. Interestingly, HLA-G and MICA/B were expressed in retinoblastoma cell, whereas MICA and ULBP-2 were not detected. Moreover, HLA-G and MICA/B were primarily detected in proliferative area of the tumor periphery with high Ki-67 immunostaining. Our results suggest that NKG2D ligands are differentially expressed in retinoblastoma, which would play a crucial role in immunomodulation in retinoblastoma.
authors.affiliation: Fight Against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
authors.forename: Eun Kyoung
authors.initials: EK
authors.lastname: Lee
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Jo
authors.forename: Jin Hyoung
authors.initials: JH
authors.lastname: Kim
authors.forename: Young Suk
authors.initials: YS
authors.lastname: Yu
authors.forename: Kyu-Won
authors.initials: KW
authors.lastname: Kim
authors.forename: Jeong Hun
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D003593:Cytoplasm / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D058851:GPI-Linked Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015870:Gene Expression / Q000235:genetics; D059951:HLA-G Antigens / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D019394:Ki-67 Antigen / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D008024:Ligands; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D019572:Retinal Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D012175:Retinoblastoma / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D014180:Transplantation / Q000379:methods
chemical_list: D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D036341:Intercellular Signaling Peptides and Proteins; D019394:Ki-67 Antigen; D008024:Ligands; C099187:MHC class I-related chain A; C098080:MICB antigen; C423230:ULBP2 protein, human