title: ANCA-associated vasculitis with central retinal artery occlusion developing during treatment with methimazole.
abstract: A 63-year-old woman suddenly developed central retinal artery occlusion following a slight fever while being treated with methimazole (MMI) for hyperthyroidism. She was diagnosed to have anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) based on increased inflammatory reactions with positive myeloperoxidase-ANCA in the serum. Her visual acuity remained low despite immediate treatment with corticosteroids and cyclophosphamide after cessation of MMI, which may have played a role in the pathogenesis of AAV. Central retinal artery occlusion is a rare manifestation of AAV; however, it is important with regard to the possibility of serious sequelae.
authors.affiliation: Department of Neurology and Rheumatology, Shinshu University School of Medicine, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Yasude
authors.forename: Dai
authors.initials: D
authors.lastname: Kishida
authors.forename: Ko-Ichi
authors.initials: K
authors.lastname: Tazawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsuda
authors.forename: Wataru
authors.initials: W
authors.lastname: Ishii
authors.forename: Masahide
authors.initials: M
authors.lastname: Yazaki
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D000925:Anticoagulants / Q000627:therapeutic use; D013956:Antithyroid Agents / Q000009:adverse effects*; D017985:Dalteparin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008713:Methimazole / Q000009:adverse effects*; D008875:Middle Aged; D015356:Retinal Artery Occlusion / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000925:Anticoagulants; D013956:Antithyroid Agents; D007166:Immunosuppressive Agents; D008713:Methimazole; D017985:Dalteparin