title: Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: effects on lipid profiles, inflammation markers, and quality of life.
abstract: OBJECTIVE
  This study aimed to evaluate the effects of short-term (60-d) oral supplementation with calcium fructoborate, resveratrol, and their combination on the clinical and biological statuses of subjects with stable angina pectoris.
  
  
  METHODS
  A randomized, double-blinded, active-controlled, parallel clinical trial was conducted in three groups of subjects. Of the total number of subjects included in study (n = 166), 87 completed the 60-d test treatment study period and 29 followed in parallel their usual medical care and treatment. The primary outcomes were inflammation biomarkers (high-sensitivity C-reactive protein), left ventricular function markers (N-terminal prohormone of brain natriuretic peptide), and lipid markers (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triacylglycerols). Quality of life was assessed by the Canadian Cardiovascular Society angina class and the number of angina attacks per week.
  
  
  RESULTS
  There was a significant decrease of high-sensitivity C-reactive protein in all groups at the 30-d and 60-d visits. This decrease was greater (39.7% at 60 d) for group 3 (calcium fructoborate), followed by group 2 (resveratrol plus calcium fructoborate, 30.3% at 60 d). The N-terminal prohormone of brain natriuretic peptide was significantly lowered by resveratrol (group 1, 59.7% at 60 d) and by calcium fructoborate (group 3, 52.6% at 60 d). However, their combination (group 2) was the most effective and induced a decrease of 65.5%. Lipid markers showed slight changes from baseline in all groups. The improvement in the quality of life was best observed for subjects who received the resveratrol and calcium fructoborate mixture (group 2).
  
  
  CONCLUSIONS
  The results indicate that the combination of resveratrol and calcium fructoborate has beneficial effects in patients with angina
authors.affiliation: Craiova Cardiology Center, Craiova, Romania.
authors.forename: Constantin
authors.initials: C
authors.lastname: Militaru
authors.forename: Ionut
authors.initials: I
authors.lastname: Donoiu
authors.forename: Alina
authors.initials: A
authors.lastname: Craciun
authors.forename: Iulia Daria
authors.initials: ID
authors.lastname: Scorei
authors.forename: Anca Mihaela
authors.initials: AM
authors.lastname: Bulearca
authors.forename: Romulus Ion
authors.initials: RI
authors.lastname: Scorei
mesh_terms: D000284:Administration, Oral; D000368:Aged; D060050:Angina, Stable / Q000097:blood* / Q000178:diet therapy* / Q000503:physiopathology; D001881:Borates / Q000008:administration & dosage*; D002097:C-Reactive Protein / Q000378:metabolism; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011788:Quality of Life; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage*
chemical_list: D001881:Borates; D018836:Inflammation Mediators; D008055:Lipids; D010446:Peptide Fragments; D013267:Stilbenes; C507177:calcium fructoborate; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D005632:Fructose; D002097:C-Reactive Protein; D000077185:Resveratrol