title: Relationship between sleep/wakefulness and gastroesophageal reflux in symptomatic newborns.
abstract: The state of sleep/wakefulness is well known to influence esophageal acid exposure and the number of acid refluxes whereas it is uncertain whether the same is true of the non-acid refluxes that predominate in the newborns. To investigate the relationship between sleep/wakefulness and refluxes 45 newborns with gastroesophageal reflux symptoms were studied with combined multichannel intraluminal impedance and pH monitoring. We found that sleep/wakefulness influenced acid and weakly acidic reflux frequency (awake 2.6+/-0.8; asleep 2.1+/-1.1; p=0.006). A negative correlation was found between sleepness periods and the mean reflux duration for both acid (R=0.55;p < 0.001) and weackly acidic (R=0.51;p < 0.001) refluxes. This finding may raise some concerns about the over-prescription of antacid drugs in newborns.
authors.affiliation: Neonatal Unit, University of Turin, 1026 Torino, Italy. francesco.cresi@unito.it
authors.forename: F
authors.initials: F
authors.lastname: Cresi
authors.forename: E
authors.initials: E
authors.lastname: Locatelli
authors.forename: E
authors.initials: E
authors.lastname: Maggiora
authors.forename: P
authors.initials: P
authors.lastname: Di Nicola
authors.forename: E
authors.initials: E
authors.lastname: Cester
authors.forename: G
authors.initials: G
authors.lastname: Sabatino
authors.forename: C
authors.initials: C
authors.lastname: Martano
authors.forename: F
authors.initials: F
authors.lastname: Giuliani
authors.forename: E
authors.initials: E
authors.lastname: Bertino
mesh_terms: D000863:Antacids / Q000627:therapeutic use; D001724:Birth Weight; D001827:Body Height; D000075202:Contraindications; D017097:Electric Impedance; D004566:Electrodes; D004947:Esophagus / Q000187:drug effects / Q000503:physiopathology*; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D041943:Infant Formula; D007231:Infant, Newborn; D008895:Milk, Human; D012890:Sleep; D014851:Wakefulness
chemical_list: D000863:Antacids