title: [Successful chemotherapy with a docetaxel regimen for primary signet-ring cell carcinoma of the urinary bladder-a case report].
abstract: Primary signet-ring cell carcinoma of the bladder is rare and has a poor prognosis. In addition, there are few successful chemotherapies for it. We report a case of chemotherapy with a docetaxel regimen which was efficacious in a 64-year-old Japanese man suffering from the disease. The onset of bilateral hydronephrosis led to the detection of his bladder tumor, and its pathological diagnosis was signet-ring cell carcinoma(immunohistochemistry showed cytokeratin 7+/20±). He was treated with chemotherapy rather than with surgery because the tumor invaded the abdominal wall and groin. To treat his disease, we performed 2 courses of a chemotherapy regimen comprised of S-1 and cisplatin, but it was not efficacious. We chose docetaxel as a second-line chemotherapy regimen,(60mg/m2, tri-weekly), and a clinical examination including contrast-enhanced CT showed that his disease had successfully responded to the chemotherapy.
authors.affiliation: Dept. of Medical Oncology, Tohoku Rosai Hospital.
authors.forename: Keita
authors.initials: K
authors.lastname: Tagami
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tanda
authors.forename: Yohei
authors.initials: Y
authors.lastname: Satake
authors.forename: Akira
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Abe
authors.forename: Takashige
authors.initials: T
authors.lastname: Namima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kusunose
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Muto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagura
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D000077143:Docetaxel; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D043823:Taxoids / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel