title: Chronic bilateral T1 denervation in women with macromastia.
abstract: BACKGROUND
  The objective of this study was to identify the pattern of neurological deficits and document electrophysiological changes in women with macromastia.
  
  
  METHODS
  Patients with macromastia and neurological complaints underwent clinical evaluation and electrodiagnostic (EDx) studies of the upper limbs.
  
  
  RESULTS
  Findings include low-amplitude medial antebrachial cutaneous (MACN) sensory nerve action potentials (SNAPs) and median compound muscle action potentials (CMAPs) and chronic denervation changes in the bilateral abductor pollicis brevis (APB) muscles on needle electrode examination (NEE), indicating axonal loss in the bilateral T1 distribution.
  
  
  CONCLUSIONS
  The EDx data are in keeping with lesions involving bilateral T1 anterior primary rami (APR). Potential sites of compromise of the T1 APR are discussed. Further study of the effect of treatment for macromastia on the clinical and EDx findings is proposed.
authors.affiliation: Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, USA. villiandgyri@aol.com
authors.forename: Jacqueline R
authors.initials: JR
authors.lastname: Ansell
authors.forename: Michael C
authors.initials: MC
authors.lastname: Buchholz
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000328:Adult; D000368:Aged; D001940:Breast / Q000002:abnormalities / Q000503:physiopathology; D004568:Electrodiagnosis; D004576:Electromyography; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000150:complications* / Q000503:physiopathology; D008475:Median Nerve / Q000503:physiopathology; D020423:Median Neuropathy / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology*; D014459:Ulnar Nerve / Q000503:physiopathology; D020424:Ulnar Neuropathies / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology