title: Survival and failure outcomes in locally advanced esthesioneuroblastoma: a single centre experience of 15 patients.
abstract: Esthesioneuroblastoma (ENB) constitutes 3 % of all malignant intranasal tumors. As the tumor is very rare, the number of patients of ENB treated in individual departments is small. We present our institute's experience in combined modality management of 15 successive patients of ENB treated from 2006 to 2010. Clinical characteristics and treatment modality in form of surgery, radiotherapy and chemotherapy were noted. Kadish stage C was the most common stage (12 patients) followed by stage B (3 patients). Fourteen patients underwent primary surgery, of which nine had total excision and five had subtotal excision. One patient was treated with combination of chemotherapy (CT) and radiotherapy (RT). Median RT dose delivered was 54 Gy. Twelve patients received CT with cisplatin and etoposide. Overall, eight patients had complete response, five had partial response, while one had static disease and progressive disease each. Two patients had distant metastases. Four-year loco-regional control (LRC) was 25 % and 4-year overall survival (OS) was 45 %. Most common presentation in our series was locally advanced tumors. Most of these patients require adjuvant RT, which helps in significant LRC. Systemic CT benefits in inoperable, advanced and high risk tumors. Risk-adapted and multimodality approach is the need of hour to achieve good control rates while minimizing treatment related toxicity.
authors.affiliation: Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. riteshkr9@gmail.com
authors.forename: Ritesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Sushmita
authors.initials: S
authors.lastname: Ghoshal
authors.forename: Divya
authors.initials: D
authors.lastname: Khosla
authors.forename: Shreekant
authors.initials: S
authors.lastname: Bharti
authors.forename: Ashim
authors.initials: A
authors.lastname: Das
authors.forename: Narendra
authors.initials: N
authors.lastname: Kumar
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kapoor
authors.forename: Suresh Chander
authors.initials: SC
authors.lastname: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D018304:Esthesioneuroblastoma, Olfactory / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome