title: Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology.
abstract: The serotonin (5-HT) receptors of type 6 (5-HT6) are quite different from all other 5-HT receptors, as they include a short third cytoplasmatic loop and a long C-terminal tail, and one intron located in the middle of the third cytoplasmatic loop. A lot of controversies still exist regarding their binding affinity, effects of 5-HT6 ligands on brain catecholamines, behavioral syndromes regulated by them, and brain distribution. In spite of the lack of information on metabolic pattern of the various compounds, some of 5-HT6 receptor ligands entered the clinical development as potential anti-dementia, antipsychotic, antidepressant and anti-obese drugs. The present paper is a comprehensive review on the state of art of the 5-HT6 receptors, while highlighting the potential clinical applications of 5-HT6 receptor agonists/antagonists.
authors.affiliation: Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, via Roma, 67, I-56100 Pisa, Italy. dmarazzi@psico.med.unipi.it
authors.forename: Donatella
authors.initials: D
authors.lastname: Marazziti
authors.forename: Stefano
authors.initials: S
authors.lastname: Baroni
authors.forename: Franco
authors.initials: F
authors.lastname: Borsini
authors.forename: Michela
authors.initials: M
authors.lastname: Picchetti
authors.forename: Elena
authors.initials: E
authors.lastname: Vatteroni
authors.forename: Valentina
authors.initials: V
authors.lastname: Falaschi
authors.forename: Mario
authors.initials: M
authors.lastname: Catena-Dell'Osso
mesh_terms: D000818:Animals; D006801:Humans; D008024:Ligands; D009488:Neurosciences; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C097216:serotonin 6 receptor