title: The effort to make mosaic analysis a household tool.
abstract: The analysis of genetic mosaics, in which an animal carries populations of cells with differing genotypes, is a powerful tool for understanding developmental and cell biology. In 1990, we set out to improve the methods used to make genetic mosaics in Drosophila by taking advantage of recently developed approaches for genome engineering. These efforts led to the work described in our 1993 Development paper.
authors.affiliation: Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06510, USA. tian.xu@yale.edu
authors.forename: Tian
authors.initials: T
authors.lastname: Xu
authors.forename: Gerald M
authors.initials: GM
authors.lastname: Rubin
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004254:DNA Nucleotidyltransferases / Q000235:genetics / Q000502:physiology; D004330:Drosophila / Q000235:genetics; D005820:Genetic Testing / Q000706:statistics & numerical data* / Q000639:trends; D016678:Genome / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D009030:Mosaicism; D011995:Recombination, Genetic / Q000502:physiology
chemical_list: D004254:DNA Nucleotidyltransferases; C045119:FLP recombinase