title: Correction of eddy current distortions in high angular resolution diffusion imaging.
abstract: OBJECTIVE
  To correct distortions caused by eddy currents induced by large diffusion gradients during high angular resolution diffusion imaging without any auxiliary reference scans.
  
  
  METHODS
  Image distortion parameters were obtained by image coregistration, performed only between diffusion-weighted images with close diffusion gradient orientations. A linear model that describes distortion parameters (translation, scale, and shear) as a function of diffusion gradient directions was numerically computed to allow individualized distortion correction for every diffusion-weighted image.
  
  
  RESULTS
  The assumptions of the algorithm were successfully verified in a series of experiments on phantom and human scans. Application of the proposed algorithm in high angular resolution diffusion images markedly reduced eddy current distortions when compared to results obtained with previously published methods.
  
  
  CONCLUSIONS
  The method can correct eddy current artifacts in the high angular resolution diffusion images, and it avoids the problematic procedure of cross-correlating images with significantly different contrasts resulting from very different gradient orientations or strengths.
authors.affiliation: Dana and David Dornsife Cognitive Neuroscience Imaging Center, University of Southern California, Los Angeles, California, USA. jc.zhuang@gmail.com
authors.forename: Jiancheng
authors.initials: J
authors.lastname: Zhuang
authors.forename: Zhong-Lin
authors.initials: ZL
authors.lastname: Lu
authors.forename: Christine Bouteiller
authors.initials: CB
authors.lastname: Vidal
authors.forename: Hanna
authors.initials: H
authors.lastname: Damasio
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult