title: Mitochondrial sirtuins and metabolic homeostasis.
abstract: The maintenance of metabolic homeostasis requires the well-orchestrated network of several pathways of glucose, lipid and amino acid metabolism. Mitochondria integrate these pathways and serve not only as the prime site of cellular energy harvesting but also as the producer of many key metabolic intermediates. The sirtuins are a family of NAD(+)-dependent enzymes, which have a crucial role in the cellular adaptation to metabolic stress. The mitochondrial sirtuins SIRT3, SIRT4 and SIRT5 together with the nuclear SIRT1 regulate several aspects of mitochondrial physiology by controlling post-translational modifications of mitochondrial protein and transcription of mitochondrial genes. Here we discuss current knowledge how mitochondrial sirtuins and SIRT1 govern mitochondrial processes involved in different metabolic pathways.
authors.affiliation: Laboratory for Integrative and Systems Physiology, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
authors.forename: Eija
authors.initials: E
authors.lastname: Pirinen
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lo Sasso
authors.forename: Johan
authors.initials: J
authors.lastname: Auwerx
mesh_terms: D002952:Citric Acid Cycle; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D024101:Mitochondrial Proteins; D037761:Sirtuins; D005947:Glucose