title: Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats.
abstract: The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg-1, 7.5 mg kg-1, or 15 mg kg-1 b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg-1, 2000 mg kg-1, or 4000 mg kg-1 b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.
authors.affiliation: Department of Toxicology Akademik Danilo Soldatović, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Belgrade, Serbia. makitox@pharmacy.bg.ac.rs
authors.forename: Marijana
authors.initials: M
authors.lastname: Curčić
authors.forename: Saša
authors.initials: S
authors.lastname: Janković
authors.forename: Vesna
authors.initials: V
authors.lastname: Jaćević
authors.forename: Sanja
authors.initials: S
authors.lastname: Stanković
authors.forename: Slavica
authors.initials: S
authors.lastname: Vučinić
authors.forename: Ksenija
authors.initials: K
authors.lastname: Durgo
authors.forename: Zorica
authors.initials: Z
authors.lastname: Bulat
authors.forename: Biljana
authors.initials: B
authors.lastname: Antonijević
mesh_terms: D000818:Animals; D002104:Cadmium / Q000008:administration & dosage* / Q000633:toxicity*; D045424:Complex Mixtures / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000633:toxicity*; D055768:Halogenated Diphenyl Ethers / Q000008:administration & dosage* / Q000633:toxicity*; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013972:Thyrotropin / Q000187:drug effects* / Q000378:metabolism; D013974:Thyroxine / Q000187:drug effects; D014284:Triiodothyronine / Q000187:drug effects
chemical_list: D045424:Complex Mixtures; D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D002104:Cadmium; D014284:Triiodothyronine; D013972:Thyrotropin; C010902:decabromobiphenyl ether; D013974:Thyroxine