title: Cell biology: cohesin ring exit gate revealed.
abstract: A multiprotein complex called cohesin mediates sister chromatid cohesion by entrapping sister DNAs into a tripartite ring. Recent studies show that Wapl opens the newly identified DNA exit gate of the cohesin ring, only when Smc3 is deacetylated, and that mutations in human Smc3 deacetylase cause a developmental disorder.
authors.affiliation: Laboratory of Chomosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1Yayoi, Tokyo 113-0032, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Yamagishi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002875:Chromosomes; D004247:DNA / Q000737:chemistry*; D003635:De Lange Syndrome / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism*; D009154:Mutation; D012441:Saccharomyces cerevisiae; D000097722:Cohesins
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004247:DNA; D046912:Multiprotein Complexes; D000097722:Cohesins