title: Three-component, one-pot sequential synthesis of functionalized cyclazines: 3H-1,2a1,3-triazaacenaphthylenes.
abstract: An efficient tandem route to the synthesis of 3H-1,2a(1),3-triazaacenaphthylene derivatives of the cyclazine family has been developed. Target compounds were obtained in moderate to good yields by a Yb(OTf)(3)/Ag(2)CO(3)-catalyzed, three-component domino reaction. This in turn will set the stage for a wide application of this useful reaction for the synthesis of structurally diverse polyheterocyclic skeletons containing the imidazo[1,2-a]pyridine privileged structure.
authors.affiliation: School of Chemistry and Pharmaceutical Engineering, Shandong Polytechnic University, Jinan 250353, P.R. China.
authors.forename: Hongpeng
authors.initials: H
authors.lastname: Sun
authors.forename: Huayong
authors.initials: H
authors.lastname: Zhou
authors.forename: Oleg
authors.initials: O
authors.lastname: Khorev
authors.forename: Ruwei
authors.initials: R
authors.lastname: Jiang
authors.forename: Ting
authors.initials: T
authors.lastname: Yu
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Yongli
authors.initials: Y
authors.lastname: Du
authors.forename: Yi
authors.initials: Y
authors.lastname: Ma
authors.forename: Tao
authors.initials: T
authors.lastname: Meng
authors.forename: Jingkang
authors.initials: J
authors.lastname: Shen
mesh_terms: D000073:Acenaphthenes / Q000138:chemical synthesis* / Q000737:chemistry*; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000073:Acenaphthenes; D001372:Aza Compounds; D011725:Pyridines; C001439:imidazo(1,2-a)pyridine