title: Unusual 9,19 : 24,32-dicyclotetracyclic triterpenoids from Lygodium japonicum.
abstract: Lygodipenoids A (1) and B (2), two novel C33 tetracyclic triterpenoids with a new 9,19 : 24,32-dicyclopropane skeleton, were isolated from the whole grass of Lygodium japonicum. Their structures were elucidated by spectroscopic and chemical means. Compounds 1 and 2 were tested in transfected cultured human embryonic kidney 293 HEK293 cells for an agonist assay, and compound 1 was identified as a partial agonist for liver X receptor α.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
authors.forename: Qing-hua
authors.initials: QH
authors.lastname: Han
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Wen-qing
authors.initials: WQ
authors.lastname: Yao
authors.forename: Zhong-bin
authors.initials: ZB
authors.lastname: Cheng
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Lin
authors.forename: Ching
authors.initials: C
authors.lastname: Song
authors.forename: Sheng
authors.initials: S
authors.lastname: Yin
mesh_terms: D029624:Ferns / Q000737:chemistry*; D057809:HEK293 Cells / Q000187:drug effects; D006801:Humans; D000071518:Liver X Receptors; D015394:Molecular Structure; D057093:Orphan Nuclear Receptors / Q000187:drug effects*; D035261:Plant Components, Aerial / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; D057093:Orphan Nuclear Receptors; D014315:Triterpenes