title: Protective effects of dietary fibre against manganese-induced neurobehavioral aberrations in rats.
abstract: We tested the hypothesis that dietary fibre (DF) has protective effects against manganese (Mn)-induced neurotoxicity. Forty-eight one-month old Sprague-Dawley rats were randomly divided into six groups: control, 16 % DF, Mn (50 mg kg-1 body weight), Mn+ 4 % DF, Mn+ 8 % DF, and Mn+ 16 % DF. After oral administration of Mn (as MnCl2) by intragastric tube during one month, we determined Mn concentrations in the blood, liver, cerebral cortex, and stool and tested neurobehavioral functions. Administration of Mn was associated with increased Mn concentration in the blood, liver, and cerebral cortex and increased Mn excretion in the stool. Aberrations in neurobehavioral performance included increases in escape latency and number of errors and decrease in step-down latency. Irrespective of the applied dose, the addition of DF in forage decreased tissue Mn concentrations and increased Mn excretion rate in the stool by 20 % to 35 %. All neurobehavioral aberrations were also improved. Our findings show that oral exposure to Mn may cause neurobehavioral abnormalities in adult rats that could be efficiently alleviated by concomitant supplementation of DF in animal feed.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Zunyi Medical College, Zunyi, China
authors.forename: Xiu-Quan
authors.initials: XQ
authors.lastname: Shi
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.forename: Ke-Yue
authors.initials: KY
authors.lastname: Wang
authors.forename: Qi-Yuan
authors.initials: QY
authors.lastname: Fan
authors.forename: Yan
authors.initials: Y
authors.lastname: Zou
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004043:Dietary Fiber / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D020149:Manganese Poisoning / Q000150:complications / Q000517:prevention & control*; D009422:Nervous System Diseases / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D020011:Protective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004043:Dietary Fiber; D020011:Protective Agents