title: Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers.
abstract: The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.
authors.affiliation: Australian Centre for NanoMedicine (ACN), School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia.
authors.forename: Hien T T
authors.initials: HT
authors.lastname: Duong
authors.forename: Zulkamal M
authors.initials: ZM
authors.lastname: Kamarudin
authors.forename: Rafael B
authors.initials: RB
authors.lastname: Erlich
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Mathew W
authors.initials: MW
authors.lastname: Jones
authors.forename: Maria
authors.initials: M
authors.lastname: Kavallaris
authors.forename: Cyrille
authors.initials: C
authors.lastname: Boyer
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Davis
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry* / Q000633:toxicity; D011108:Polymers / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011108:Polymers; D014867:Water; D009569:Nitric Oxide; D005978:Glutathione