title: MRI perfusion in determining pseudoprogression in patients with glioblastoma.
abstract: We examine the role of dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) perfusion in differentiating pseudoprogression from progression in 20 consecutive patients with treated glioblastoma. MRI perfusion was performed, and relative cerebral blood volume (rCBV), relative peak height (rPH), and percent signal recovery (PSR) were measured. Pseudoprogression demonstrated lower median rCBV (P=.009) and rPH (P<.001), and higher PSR (P=.039) than progression. DSC MRI perfusion successfully identified pseudoprogression in patients who did not require a change in treatment despite radiographic worsening following chemoradiotherapy.
authors.affiliation: Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. youngr@mskcc.org
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Young
authors.forename: Ajay
authors.initials: A
authors.lastname: Gupta
authors.forename: Akash D
authors.initials: AD
authors.lastname: Shah
authors.forename: Jerome J
authors.initials: JJ
authors.lastname: Graber
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Chan
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Weiji
authors.initials: W
authors.lastname: Shi
authors.forename: Kathryn
authors.initials: K
authors.lastname: Beal
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Omuro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D002648:Child; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005909:Glioblastoma / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control*; D009518:New York / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult