title: Cholesterol and phospholipids in frontal cortex and synaptosomes of suicide completers: relationship with endosomal lipid trafficking genes.
abstract: Cholesterol (CHL) and phospholipid (PL) levels in synaptosomal membranes in particular can have an impact on cell signalling. Alterations in peripheral CHL measures have been consistently reported in suicidal behaviour. As CHL and PL turnover in the brain are important in synapse maintenance and function, the objective of this study was to determine if differences exist in synaptosomal cholesterol and phospholipid levels between suicide completers and controls. Expression measures of genes involved in lipid trafficking suggest an association between Lysosomal acid lipase A, cholesteryl ester hydrolase (LIPA) and brain PL levels, with LIPA being significantly increased in violent suicides and associated with alterations in brain PL. The results of this study suggest an altered PL content mediated by LIPA expression in violent suicides in the prefrontal cortex, which would have important consequences for inhibitory neurotransmission.
authors.affiliation: Department of Human Genetics, McGill University, Montreal, QC, Canada.
authors.forename: Erika
authors.initials: E
authors.lastname: Freemantle
authors.forename: Naguib
authors.initials: N
authors.lastname: Mechawar
authors.forename: Gustavo
authors.initials: G
authors.lastname: Turecki
mesh_terms: D000199:Actins / Q000378:metabolism; D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics / Q000378:metabolism; D000704:Analysis of Variance; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D002784:Cholesterol; D011992:Endosomes; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D026502:LDL-Receptor Related Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D046529:Microscopy, Electron, Transmission; D000077296:Niemann-Pick C1 Protein; D010743:Phospholipids / Q000378:metabolism*; D018709:Statistics, Nonparametric; D002787:Sterol Esterase / Q000235:genetics / Q000378:metabolism*; D013405:Suicide; D050825:Synaptosomal-Associated Protein 25 / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism*; D050827:Syntaxin 1 / Q000378:metabolism; D000099183:Sortilin
chemical_list: D000199:Actins; D033942:Adaptor Proteins, Vesicular Transport; D001057:Apolipoproteins E; D002352:Carrier Proteins; D002784:Cholesterol; D047908:Intracellular Signaling Peptides and Proteins; D026502:LDL-Receptor Related Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D000077296:Niemann-Pick C1 Protein; D010743:Phospholipids; D002787:Sterol Esterase; D050825:Synaptosomal-Associated Protein 25; D050827:Syntaxin 1; D000099183:Sortilin; C106881:NPC1 protein, human; C494208:SNAP25 protein, human; C102582:SORL1 protein, human; C494212:STX1A protein, human; C503451:LIPA protein, human