title: Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review.
abstract: BACKGROUND
  Infertility affects approximately 10%-15% of couples in reproductive age. In half of the couples, causes are male-related, associated with impaired spermatogenesis. There is a complex correlation between genetics and infertility. Several factors affect on gametogenesis, from which factors that lead to chromosomal abnormalities are one of the best known. The aim of this study was to determine type and rate of chromosomal abnormalities in infertile azoospermic and oligospermic males in Iranian population.
  
  
  METHODS
  The records of a total of 222 participants were evaluated retrospectively.
  
  
  RESULTS
  As a whole we observed 13.96% chromosomal abnormality, from which 12.15% showed numerical and 1.8% showed structural abnormalities.
  
  
  CONCLUSIONS
  Comparison of our results with the review of the literature shows a higher incidence (4- fold) of gonosomal, in particular, numerical gonosomal, chromosomal anomalies. Cytogenetic analysis is strongly suggested for infertile men, particularly in those who suffer from azoospermia.
authors.affiliation: Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors.forename: Mohammad T
authors.initials: MT
authors.lastname: Akbari
authors.forename: F
authors.initials: F
authors.lastname: Behjati
authors.forename: G R
authors.initials: GR
authors.lastname: Pourmand
authors.forename: F Akbari
authors.initials: FA
authors.lastname: Asbagh
authors.forename: M Ataei
authors.initials: MA
authors.lastname: Kachoui