title: Accommodative changes in human eye observed by Kitasato anterior segment optical coherence tomography.
abstract: OBJECTIVE
  To study accommodative changes in the human lens using swept-source optical coherence tomography (Kitasato anterior segment OCT/KAs-OCT), which can image the whole anterior segment of the eye.
  
  
  METHODS
  Thirty-five healthy subjects (mean age 41 years, range 13-79 years) were recruited. Using KAs-OCT, we measured the curvature of the anterior (ASC) and posterior surfaces (PSC), the thickness (LT) of the lens and the anterior chamber depth (ACD) in response to far (0.4 D) and near (10 D) accommodative stimuli.
  
  
  RESULTS
  In response to accommodative stimuli (0.4/10 D), the mean values ± standard deviations were: radius of ASC, 9.72 ± 2.53/7.84 ± 1.85 mm (Wilcoxon ranked-sign test, p < 0.0001); radius of PSC, 5.06 ± 0.71/4.70 ± 0.76 mm (p = 0.0012); LT, 3.86 ± 0.77/4.00 ± 0.76 mm (p < 0.0001); ACD, 2.72 ± 0.61/2.61 ± 0.54 mm (p = 0.0002). The rate of accommodation-associated changes in ASC, LT, and ACD showed significant correlation with aging (Pearson correlation coefficient: r = -0.725, p < 0.0001; r = -0.626, p = 0.0001; r = -0.720, p < 0.0001, respectively), but there was no such correlation in PSC (r = -0.064, p = 0.401).
  
  
  CONCLUSIONS
  The radius of ASC and PSC decreased with accommodation, and the rates of changes in ASC were larger than those in PSC.
authors.affiliation: Department of Ophthalmology, University of Kitasato School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 252-0374, Japan. nosatou-ktz@umin.org
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Satoh
authors.forename: Kimiya
authors.initials: K
authors.lastname: Shimizu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Goto
authors.forename: Akihito
authors.initials: A
authors.lastname: Igarashi
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Kamiya
authors.forename: Kohji
authors.initials: K
authors.lastname: Ohbayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D000065:Accommodation, Ocular / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000869:Anterior Eye Segment / Q000033:anatomy & histology* / Q000502:physiology; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult