title: Neuroprotective lignans from the stems of Schisandra glaucescens.
abstract: Two new tetrahydrofuran lignans, schiglaucin A and B (1-2), together with eight known analogues (3-10), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic techniques (HRESIMS, UV, IR, NMR, and CD experiments). All of the compounds were tested for their neuroprotective activities against H₂O₂- and CoCl₂-induced cell injuries in SH-SY5Y cells, respectively. Compounds 1-10 showed significant neuroprotective effects against H₂O₂-induced SH-SY5Y cell death, while compounds 1-5 and 8-10 exhibited significant neuroprotective effects against CoCl₂-induced SH-SY5Y cell injury.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Heng-Yi
authors.initials: HY
authors.lastname: Yu
authors.forename: Cui
authors.initials: C
authors.lastname: Hao
authors.forename: Fan-Yu
authors.initials: FY
authors.lastname: Meng
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Zu-Yu
authors.initials: ZY
authors.lastname: Chen
authors.forename: Xi
authors.initials: X
authors.lastname: Liang
authors.forename: Han-Li
authors.initials: HL
authors.lastname: Ruan
mesh_terms: D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003035:Cobalt; D006801:Humans; D006861:Hydrogen Peroxide; D017705:Lignans / Q000494:pharmacology*; D015394:Molecular Structure; D009447:Neuroblastoma / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D017705:Lignans; D018696:Neuroprotective Agents; D010936:Plant Extracts; D003035:Cobalt; D006861:Hydrogen Peroxide; C018021:cobaltous chloride