title: The primate ventral pallidum encodes expected reward value and regulates motor action.
abstract: Motor actions are facilitated when expected reward value is high. It is hypothesized that there are neurons that encode expected reward values to modulate impending actions and potentially represent motivation signals. Here, we present evidence suggesting that the ventral pallidum (VP) may participate in this process. We recorded single neuronal activity in the monkey VP using a saccade task with a direction-dependent reward bias. Depending on the amount of the expected reward, VP neurons increased or decreased their activity tonically until the reward was delivered, for both ipsiversive and contraversive saccades. Changes in expected reward values were also associated with changes in saccade performance (latency and velocity). Furthermore, bilateral muscimol-induced inactivation of the VP abolished the reward-dependent changes in saccade latencies. These data suggest that the VP provides expected reward value signals that are used to facilitate or inhibit motor actions.
authors.affiliation: Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA. banao@nips.ac.jp
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Tachibana
authors.forename: Okihide
authors.initials: O
authors.lastname: Hikosaka
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D003463:Cues; D058785:GABA-A Receptor Agonists / Q000494:pharmacology; D005917:Globus Pallidus / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009118:Muscimol / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D012372:ROC Curve; D011930:Reaction Time / Q000187:drug effects; D012201:Reward; D012438:Saccades / Q000502:physiology
chemical_list: D058785:GABA-A Receptor Agonists; D009118:Muscimol