title: Changes in the adult vertebrate auditory sensory epithelium after trauma.
abstract: Auditory hair cells transduce sound vibrations into membrane potential changes, ultimately leading to changes in neuronal firing and sound perception. This review provides an overview of the characteristics and repair capabilities of traumatized auditory sensory epithelium in the adult vertebrate ear. Injured mammalian auditory epithelium repairs itself by forming permanent scars but is unable to regenerate replacement hair cells. In contrast, injured non-mammalian vertebrate ear generates replacement hair cells to restore hearing functions. Non-sensory support cells within the auditory epithelium play key roles in the repair processes.
authors.affiliation: Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, CHDD CD176, Box 357923, Univ. of Washington, Seattle, WA 98195-7923, USA. oesterle@uw.edu
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Oesterle
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D007758:Ear, Inner / Q000502:physiology* / Q000503:physiopathology; D004848:Epithelium / Q000473:pathology*; D006198:Hair Cells, Auditory / Q000502:physiology*; D006309:Hearing; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology; D006801:Humans; D008564:Membrane Potentials; D009416:Nerve Regeneration / Q000502:physiology*; D009925:Organ of Corti / Q000503:physiopathology; D012038:Regeneration / Q000502:physiology*; D013136:Spiral Ganglion / Q000473:pathology; D033581:Stem Cell Transplantation / Q000379:methods; D014714:Vertebrates / Q000502:physiology; D014947:Wounds and Injuries
chemical_list: D019208:Brain-Derived Neurotrophic Factor