title: Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory.
abstract: Nr4a1 and Nr4a2 are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression of either Nr4a1 or Nr4a2, we found that Nr4a2 is necessary for both long-term memory for object location and object recognition. In contrast, Nr4a1 appears to be necessary only for object location. Indeed, their roles in these different types of long-term memory may be dependent on their expression in the brain, as NR4A2 was found to be expressed in hippocampal neurons (associated with object location memory) as well as in the insular and perirhinal cortex (associated with object recognition memory), whereas NR4A1 showed minimal neuronal expression in these cortical areas. These results begin to elucidate how NR4A1 and NR4A2 differentially contribute to object location versus object recognition memory.
authors.affiliation: Department of Neurobiology & Behavior, Center for the Neurobiology of Learning & Memory, University of California, Irvine, Irvine, California 92697-3800, USA.
authors.forename: Susan E
authors.initials: SE
authors.lastname: McNulty
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Barrett
authors.forename: Annie
authors.initials: A
authors.lastname: Vogel-Ciernia
authors.forename: Melissa
authors.initials: M
authors.lastname: Malvaez
authors.forename: Nicole
authors.initials: N
authors.lastname: Hernandez
authors.forename: M Felicia
authors.initials: MF
authors.lastname: Davatolhagh
authors.forename: Dina P
authors.initials: DP
authors.lastname: Matheos
authors.forename: Aaron
authors.initials: A
authors.lastname: Schiffman
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: Wood
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D007858:Learning; D008297:Male; D057567:Memory, Long-Term / Q000187:drug effects / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1 / Q000235:genetics / Q000378:metabolism*; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2 / Q000235:genetics / Q000378:metabolism*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D034741:RNA, Small Interfering / Q000494:pharmacology; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
chemical_list: C539818:Nr4a1 protein, mouse; C539883:Nr4a2 protein, mouse; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D010751:Phosphopyruvate Hydratase