title: Urinary follicle-stimulating hormone as a measure of natural fertility in a community cohort.
abstract: High serum follicle-stimulating hormone (FSH) levels have been associated with diminished ovarian reserve; however, the association between high urinary FSH and reduced natural fertility has yet to be established. We sought to characterize the relationship between a single or multiple measurements of early follicular phase urinary FSH and fertility. Women (n = 209), 30 to 44 years old with no history of infertility, who had been trying to conceive for less than 3 months, provided early follicular phase urine. Participants subsequently kept a diary to record bleeding and intercourse and conducted standardized pregnancy testing for up to 6 months. A subset of women (N = 95) collected urine on cycle day 3 for up to 6 cycles. Urine was analyzed for FSH and creatinine (cr) corrected. Proportional hazard models were used to calculate fecundability ratios (FRs). Urinary FSH levels across cycles from the same woman were highly correlated (adjusted intraclass correlation = .77); within-woman variance was 3-fold lower than variance among women. Women with an initial urinary FSH level <7 mIU/mg cr exhibited a nonsignificant reduction in the probability of pregnancy (adjusted FR 0.71, 95% confidence interval [CI]: 0.45-1.13), as did women with elevated urinary FSH (≥12 mIU/mg cr; adjusted FR 0.78, 95% CI: 0.46-1.32). Using the most recent or maximum urinary FSH value did not strengthen the association. In the general population, urinary FSH levels appear to be nonlinearly associated with fertility; however, broad CIs indicate a lack of statistical significance. Repetitive testing appears to be of little benefit.
authors.affiliation: Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA. asteiner@med.unc.edu
authors.forename: Anne Z
authors.initials: AZ
authors.lastname: Steiner
authors.forename: D Leann
authors.initials: DL
authors.lastname: Long
authors.forename: Amy H
authors.initials: AH
authors.lastname: Herring
authors.forename: James S
authors.initials: JS
authors.lastname: Kesner
authors.forename: Juliana W
authors.initials: JW
authors.lastname: Meadows
authors.forename: Donna D
authors.initials: DD
authors.lastname: Baird
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D015331:Cohort Studies; D003404:Creatinine / Q000652:urine; D005260:Female; D005298:Fertility; D043373:Follicle Stimulating Hormone, Human / Q000652:urine*; D006801:Humans; D053208:Kaplan-Meier Estimate; D015999:Multivariate Analysis; D017711:Nonlinear Dynamics; D009657:North Carolina; D010061:Ovulation Detection / Q000379:methods*; D011237:Predictive Value of Tests; D011247:Pregnancy; D016016:Proportional Hazards Models; D015203:Reproducibility of Results; D013997:Time Factors; D061685:Time-to-Pregnancy
chemical_list: D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; D003404:Creatinine