title: Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody.
abstract: Monoclonal antibodies (mAb) induce tumor regression through antibody-dependant cellular cytotoxicity (ADCC). We recently showed that an agonistic anti-CD137 mAb stimulates natural killer (NK) cells which have been activated by a tumor-specific mAb, resulting in increased ADCC against cancer cells.
authors.affiliation: CHU Rennes; Serivice Hématologie Clinique; Rennes, France.
authors.forename: Roch
authors.initials: R
authors.lastname: Houot
authors.forename: Holbrook
authors.initials: H
authors.lastname: Kohrt
authors.forename: Ron
authors.initials: R
authors.lastname: Levy