title: Motor cortex stimulation modulates defective central beta rhythms in patients with neuropathic pain.
abstract: OBJECTIVE
  Motor cortex stimulation therapy (MCS) is increasingly used to control refractory neuropathic pain. Post-movement beta synchronization (PMBS) is defined as a sharp increase in beta-frequency electroencephalographic power following movement offset and may reflect sensorimotor cortex inhibition induced, at least in part, by cortical processing of movement-related sensory afferent inputs. PMBS pattern is then often altered in case of neuropathic pain. The main objective of the present study was to test the hypothesis that implanted MCS modulates PMBS in patients presenting with neuropathic pain.
  
  
  METHODS
  Using a high-resolution, 128-electrode electroencephalographic system, we recorded and compared, before and during MCS, PMBS patterns during brisk, unilateral right and left index finger extension in 8 patients presenting with neuropathic pain.
  
  
  RESULTS
  The pre-operative PMBS patterns were altered in all cases. MCS increased the spatial distribution and amplitude of PMBS in most of cases and restored maximum-intensity of PMBS contralateral to the painful body side. These modifications appeared significantly correlated with the analgesic effect of MCS.
  
  
  CONCLUSIONS
  This study provides evidence of central beta rhythms neuromodulation induced by MCS.
  
  
  CONCLUSIONS
  The restoration by MCS of defective cortical inhibition in patients with neuropathic pain is evoked.
authors.affiliation: Department of Functional Neurosurgery, FRE 3291 CNRS, Université Lille Nord de France, France. nicolas.reyns@chru-lille.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Reyns
authors.forename: Philippe
authors.initials: P
authors.lastname: Derambure
authors.forename: Alain
authors.initials: A
authors.lastname: Duhamel
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Bourriez
authors.forename: Serge
authors.initials: S
authors.lastname: Blond
authors.forename: Elise
authors.initials: E
authors.lastname: Houdayer
mesh_terms: D000328:Adult; D001611:Beta Rhythm / Q000502:physiology*; D003627:Data Interpretation, Statistical; D004599:Electric Stimulation Therapy / Q000379:methods*; D004567:Electrodes, Implanted; D058407:Electroencephalography Phase Synchronization; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009437:Neuralgia / Q000503:physiopathology*; D019635:Neurosurgical Procedures / Q000379:methods; D010147:Pain Measurement