title: Effectiveness of early medical abortion using low-dose mifepristone and buccal misoprostol in women with no defined intrauterine gestational sac.
abstract: BACKGROUND
  The study was conducted to assess the effectiveness of early medical abortion (EMA) in women with early pregnancy and no defined intrauterine gestational sac (IUGS) on ultrasound.
  
  
  METHODS
  Retrospective, multicenter, observational study of oral mifepristone 200 mg and buccal misoprostol 800 mcg administered 24-48 h later for EMA (gestations ≤ 63 days). Odds ratios (ORs) [95% confidence intervals (CIs)] of EMA failure and continuing pregnancy for women with no defined IUGS vs. those with confirmed IUGS were calculated.
  
  
  RESULTS
  Women with no defined IUGS were more likely to experience EMA failure [9.0% (6/67) vs. 3.5% (465/13,345); OR (95% CI)=2.72 (1.17-6.33), p=.041] and continuing pregnancy [7.5% (5/67) vs. 0.6% (83/13,345); OR (95% CI)=12.72 (4.98-32.46), p<.001].
  
  
  CONCLUSIONS
  EMA failure is more likely in women with early pregnancy and no defined IUGS than those with gestations ≤ 63 days and confirmed IUGS.
authors.affiliation: Marie Stopes International Australia, PO Box 1635, Melbourne VIC 3001, Australia. Philip.Goldstone@mariestopes.org.au
authors.forename: Philip
authors.initials: P
authors.lastname: Goldstone
authors.forename: Jill
authors.initials: J
authors.lastname: Michelson
authors.forename: Eve
authors.initials: E
authors.lastname: Williamson
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000032:Abortion, Therapeutic / Q000009:adverse effects*; D000278:Administration, Buccal; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage / Q000009:adverse effects*; D016595:Misoprostol / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging / Q000601:surgery*; D012189:Retrospective Studies; D017211:Treatment Failure; D016216:Ultrasonography, Prenatal; D014599:Uterus / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D016595:Misoprostol; D015735:Mifepristone