title: [Randomized controlled trial on the effectiveness of Corpitolinol 60 in the prevention of pressure sores in patients undergoing surgery].
abstract: Randomized controlled trial on the effectiveness of Corpitolinol 60 in the prevention of pressure sores in surgical patients.
  
  
  BACKGROUND
  The risk of pressure sores in surgical patients is widely recognised. The Corpitolinol 60 (Sanyréne®) applied on compressed areas seems to reduce the risk of pressure sores.
  
  
  OBJECTIVE
  To assess the efficacy of Corpitolinol 60 in preventing pressure sores in the operatory theatre.
  
  
  METHODS
  The open label randomized clinical trial was conducted in 5 operating theatres of Northen Italy. Patients were randomized to receive Corpitolinol 60 in areas undergoing compression. Experimental group and controls were treated with usual measures for preventing pressure sores. The lesions were staged according to NPUAP up to 24 hours after surgery.
  
  
  RESULTS
  Three-hundred-one patients were randomized (155 in the Sanyréne® group and 143 controls). The main variables predictive of pressure sores risk (ASA class, sex, age, duration of the surgery, and BMI) were comparable across groups. At the end of the surgery 71 patients (23.8%) in the experimental group and 47 controls (30.8%) had a pressure sore (p 0.006; RR 1.81 IC95% 1.17-2.79). Twelve and 24 hours after surgery the differences between groups were not significant.
  
  
  CONCLUSIONS
  The aim of reducing pressure sores was not reached for patients treated with Corpitolinol 60.
authors.affiliation: Università di Bologna. paolo.chiari@unibo.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Chiari
authors.forename: Sabina
authors.initials: S
authors.lastname: Giorgi
authors.forename: Daniela
authors.initials: D
authors.lastname: Ugolini
authors.forename: Morena
authors.initials: M
authors.lastname: Montanari
authors.forename: Pietro
authors.initials: P
authors.lastname: Giudanella
authors.forename: Antonella
authors.initials: A
authors.lastname: Gramantieri
authors.forename: Franca
authors.initials: F
authors.lastname: Collesi
authors.forename: Michelina
authors.initials: M
authors.lastname: Pau
authors.forename: Maddalena
authors.initials: M
authors.lastname: Smaldone
authors.forename: Maddalena
authors.initials: M
authors.lastname: Matarasso
authors.forename: Cinzia
authors.initials: C
authors.lastname: Mazzini
authors.forename: Francesca
authors.initials: F
authors.lastname: Russo
authors.forename: Domenica
authors.initials: D
authors.lastname: Gazineo
authors.forename: Mirella
authors.initials: M
authors.lastname: Fontana
authors.forename: Patrizia
authors.initials: P
authors.lastname: Taddia
mesh_terms: D000279:Administration, Cutaneous; D000465:Algorithms; D001458:Bandages; D001513:Beds; D016022:Case-Control Studies; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005260:Female; D005989:Glycerides / Q000008:administration & dosage*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D003668:Pressure Ulcer / Q000175:diagnosis / Q000451:nursing* / Q000517:prevention & control* / Q000628:therapy; D012720:Severity of Illness Index; D013503:Surgery Department, Hospital; D013997:Time Factors; D014945:Wound Healing
chemical_list: D003879:Dermatologic Agents; D005989:Glycerides; C110597:sanyrene