title: [Sphingosine 1-phosphate receptors: from biology to physiopathology].
abstract: Sphingosine 1-phosphate (S1P) mediates critical physiological responses by its binding to G protein-coupled receptor (GPCR) subtypes, known as S1P receptors. Five distinct mammalian S1P receptors, designated S1P1-5 have been identified, each with a different cellular pattern of expression which influences the responses to S1P. In this review, we briefly outline our understanding of the modes of action and the roles of S1P receptors in the regulation of physiological and pathological functions in the cardiovascular, immune and central nervous system.
authors.affiliation: Institut de pharmacologie et de biologie structurale, Toulouse Cedex 4, France. olivier.cuvillier@inserm.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Cuvillier
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology; D002319:Cardiovascular System / Q000503:physiopathology; D002465:Cell Movement; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008246:Lysophospholipids / Q000502:physiology*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D008322:Mammals; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology; D049349:Receptors, Lysosphingolipid / Q000145:classification / Q000172:deficiency / Q000187:drug effects / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000502:physiology
chemical_list: D008246:Lysophospholipids; D009419:Nerve Tissue Proteins; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine