title: Chest X- ray findings in HIV patients in relation to the CD4 count.
abstract: BACKGROUND
  CD4 count measures the degree of immunosupression in HIV-infected patients. Immunosupression results in lack of ability of the body to fight infections thus predisposing the individual to infection; lung is one of the most susceptible organs. An important diagnostic tool in assessing the respiratory complications as well as the manifestations of HIV infection is the chest radiograph.
  
  
  OBJECTIVE
  This study is aimed at determining the radiological features seen on chest radiographs of HIV/AIDS patients in relation to their corresponding CD4 count which is a measure of immunosupression.
  
  
  METHODS
  This study was conducted at Lagos State University Teaching Hospital (LASUTH) HIV clinic between September 2009 and August 2010 amongst all consenting registered HIV/AIDS patients. A total of one hundred and six consenting participants were recruited consecutively into the study, their blood samples were collected for CD4 count assay, and all the participants were sent for chest xray in the radiology department. They were asked to fill the structured questionnaire to obtain demographic data.
  
  
  RESULTS
  More than three-quarters, 87(82.1%) had a normal chest radiographs. The abnormal findings included 13 cases of (12.3%) pulmonary tuberculosis, 3(2.8%) having bronchopneumonia, and 3(2.8%) lobar pneumonia. Majority, 32 of 87 of those with normal chest-x ray had CD4 count <100 cells/il while about half of the patients with pulmonary tuberculosis (5 of 13) had CD4 count >350 cells/il. All the three patients who had lobar pneumonia had CD4 count between 200-350 cells/il, while 2 of 3 patients with bronchopneumonia had CD4 counts between 200-350 cells/il, only 1 of them had CD4 of 100-200 cells/il
  
  
  CONCLUSIONS
  About three-quarters of HIV-infected patients had normal chest radiographs, majority of those with normal chest x-ray were severely immunocompromised. While almost half of those with pulmonary tuberculosis had CD4 count >350 cells/il. The CD4 count level may not be an indicator of pulmonary infection.
authors.affiliation: Department of Haematology and Blood Transfusion, Lagos State University College of Medicine. ajoke_clinic@yahoo.co.uk
authors.forename: A A
authors.initials: AA
authors.lastname: Akinbami
authors.forename: A O
authors.initials: AO
authors.lastname: Adegboyega
authors.forename: O O
authors.initials: OO
authors.lastname: Oshinaike
authors.forename: P A
authors.initials: PA
authors.lastname: Adebola
authors.forename: C
authors.initials: C
authors.lastname: Enabulele
authors.forename: O A
authors.initials: OA
authors.lastname: Dosunmu
authors.forename: A
authors.initials: A
authors.lastname: Adediran
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000453:epidemiology*; D011859:Radiography; D017678:Sex Distribution; D014397:Tuberculosis, Pulmonary / Q000000981:diagnostic imaging / Q000453:epidemiology*; D055815:Young Adult