title: [Pharmacogenetics in psychiatry: how far are we from clinical application?].
abstract: Pharmacogenetics studies how genetic variation influences the response of patients to drugs. This discipline has a greater impact in those medical specialties that treat complex diseases in which the therapeutic response is insufficient and/or have high costs such as psychiatry. This is a narrative review in which we analyze the main results of pharmacogenetic studies performed with the most relevant groups of psychoactive drugs and discusses missing for incorporating these advances into our daily practice. We conclude that despite the remarkable progress in the field of Pharmacogenetics in the last 10 years, studies in psychiatry have been inconclusive and the clinical use of pharmacogenetic testing is still limited. However, there are some encouraging elements about the applicability of these tools for the improvement of psychiatric treatments.
authors.affiliation: III Cátedra de Farmacología, Facultad de Medicina, UBA. fdaray@hotmail.com
authors.forename: Federico Manuel
authors.initials: FM
authors.lastname: Daray
authors.forename: Paulo César
authors.initials: PC
authors.lastname: Maffia
authors.forename: Rodolfo Pedro
authors.initials: RP
authors.lastname: Rothlin
authors.forename: Andrea Emilse
authors.initials: AE
authors.lastname: Errasti
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics; D011570:Psychiatry
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents