title: In vivo optical-resolution photoacoustic computed tomography with compressed sensing.
abstract: Optical-resolution photoacoustic microscopy is becoming a powerful research tool for studying microcirculation in vivo. Moreover, ultrasonic-array-based optical-resolution photoacoustic computed tomography (OR-PACT), providing comparable resolution at an improved speed, has opened up new opportunities for studying microvascular dynamics. In this Letter, we have developed a compressed sensing with partially known support (CS-PKS) photoacoustic reconstruction strategy for OR-PACT. Compared with conventional backprojection reconstruction, the CS-PKS strategy was shown to produce high-quality in vivo OR-PACT images with threefold less measurement data, which can be leveraged to improve the data acquisition speed and costs of OR-PACT systems.
authors.affiliation: Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Boulevard, Nanshan, Shenzhen 518055, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Meng
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Liang
authors.forename: Liang
authors.initials: L
authors.lastname: Song
mesh_terms: D000818:Animals; D004423:Ear / Q000098:blood supply; D007091:Image Processing, Computer-Assisted; D051379:Mice; D055620:Optical Phenomena; D061088:Photoacoustic Techniques / Q000379:methods*; D014054:Tomography / Q000379:methods*