title: Epidemiology of sebaceous carcinoma in Alberta, Canada, from 1988 to 2007.
abstract: BACKGROUND
  The epidemiology of sebaceous carcinoma (SC) has not previously been examined in a Canadian population.
  
  
  OBJECTIVE
  To determine the epidemiologic trends of SC in Alberta, Canada, from 1988 to 2007.
  
  
  METHODS
  This study was a population-based, retrospective, epidemiologic analysis of SC in Alberta over a 20-year span.
  
  
  RESULTS
  Over the study period, the age-standardized SC incidence increased from 0.22 per 100,000 to 0.65 per 100,000. Sebaceous carcinoma is a cancer that predominantly affects the elderly (over 85% of cases were in persons 60 years or older). Interestingly, the face (37.7% of cases), not the eyelids (26.2% of cases), was the most frequently affected site overall. Gender-specific trends reflected a slight male predominance (1.4:1) and significant differences in anatomic distribution between the sexes.
  
  
  CONCLUSIONS
  For unexplained reasons, there has been a threefold increase in SC incidence in Alberta over the last two decades. In addition, there are significant gender-specific differences in the anatomic distribution of SC.
authors.affiliation: Division of Dermatology and Cutaneous Sciences, Department of Medicine, University of Alberta, Edmonton, AB.
authors.forename: Paul
authors.initials: P
authors.lastname: Kuzel
authors.forename: Andrei I
authors.initials: AI
authors.lastname: Metelitsa
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Dover
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Salopek
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000416:Alberta / Q000453:epidemiology; D002277:Carcinoma / Q000453:epidemiology*; D005142:Eyelid Neoplasms / Q000453:epidemiology; D005153:Facial Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012626:Sebaceous Gland Neoplasms / Q000453:epidemiology*; D012737:Sex Factors