title: Survivin gene polymorphism association with tongue squamous cell carcinoma.
abstract: METHODS
  Survivin expression is correlated with tumor aggressiveness and severity in head and neck carcinoma. A polymorphism at position -31 (G/C) (rs 9904341) has been associated with cancer risk in several studies. We evaluated the correlation of this polymorphism with clinical manifestation of patients with tongue squamous cell carcinoma (SCC) in an Irananian population.
  
  
  METHODS
  Paraffin-embedded tissue sections from patients with tongue SCC (n=91) were evaluated for association between the survivin -31 (G/C) polymorphism and tumor staging, pathological grade, lymph node metastasis, tumor size, and recurrence of tumor.
  
  
  RESULTS
  There was a significant increase of presence of allele C in patients who were at stages III and IV compared to patients with lower stages [GC+CC vs. GG, p=0.025, odds ratio [OR] 2.76, 95% confidence interval [CI] [1.03-7.4]). In addition, presence of allele C was significantly decreased in patients with T1 tumor size compared to patients with larger tumor size (p=0.03, OR 0.6, 95% CI [0.2-2.03]).
  
  
  CONCLUSIONS
  Presence of the C allele was significantly associated with tumor stage and size; therefore, survivin might be an important marker in the prognosis of tongue SCC that requires further investigation.
authors.affiliation: Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Leila Vazifeh
authors.initials: LV
authors.lastname: Mostaan
authors.forename: Azin
authors.initials: A
authors.lastname: Tabari
authors.forename: Parvin
authors.initials: P
authors.lastname: Amiri
authors.forename: Mohammadtaghi Khorsandi
authors.initials: MK
authors.lastname: Ashtiani
authors.forename: Aydin
authors.initials: A
authors.lastname: Mahdkhah
authors.forename: Nasrin
authors.initials: N
authors.lastname: Yazdani
authors.forename: Mahmood
authors.initials: M
authors.lastname: Khaniki
authors.forename: Azadeh
authors.initials: A
authors.lastname: Tabari
authors.forename: Javad
authors.initials: J
authors.lastname: Tavakkoly-Bazzaz
authors.forename: Mahsa M
authors.initials: MM
authors.lastname: Amoli
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D000077022:Survivin; D014059:Tongue / Q000378:metabolism / Q000473:pathology*; D014062:Tongue Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin