title: [Bilateral hyperintensity of the pulvinar and dorsomedial nucleus of the thalamus in sporadic Creutzfeldt-Jakob disease].
abstract: BACKGROUND
  Creutzfedt-Jakob Disease (CJD) is a rapidly progressive neurodegenerative disease caused by prions. Early diagnosis and the determination of its form are epidemiologically important, with strong impact on public health. Bilateral pulvinar hyperintensity, either alone (pulvinar sign) or in association with the dorsomedial nucleus of the thalamus (double hockey stick sign) on T2, FLAIR and diffusion weighted imaging (DWI), is a criterion for the probable diagnosis of the variant CJD (vCJD). Bilateral hyperintensity of the caudate, putamina and cortex is the usual pattern found in the sporadic CJD (sCJD).
  
  
  OBJECTIVE
  Analysis of the imaging aspects on a sCJD patient showing T2 hyperintensity of the pulvinar and dorsomedial thalamic nucleus, in order to assess the magnetic resonance imaging (MRI) accuracy in the discrimination between vCJD and sCJD, when this lesion pattern is present.
  
  
  METHODS
  We performed a MRI on a 62-year-old female with definitive diagnosis of sCJD made by anatomopathologic study of the brain tissue. Qualitative analysis of MRI, including DWI, T2 and FLAIR sequences, as well as lesional patterns found.
  
  
  RESULTS
  Brain MRI showed hyperintensity of the caudate, putamina, pulvinar and dorsomedial nucleus of the thalamus, in DWI, T2 and FLAIR sequences; hypersignal of the caudate and putamina was greater than the signal intensity of the thalami. Hyperintensity of the hippocampus and frontal, temporal and parietal cortex were more obvious in FLAIR and DWI.
  
  
  CONCLUSIONS
  Hyperintensity of the pulvinar and dorsomedial nucleus of the thalamus on sCJD may complicate the differential diagnosis with vCJD. True pulvinar sign and double hockey stick sign, consistent with vCJD, must only be considered if the hyperintensity is greater than signal intensity of the caudate and putamina.
authors.affiliation: Serviço de Imagiologia, Hospitais da Universidade de Coimbra, Coimbra, Portugal.
authors.forename: Carlos
authors.initials: C
authors.lastname: Casimiro
authors.forename: Joana
authors.initials: J
authors.lastname: Martins
authors.forename: Tiago
authors.initials: T
authors.lastname: Parreira
authors.forename: Inês
authors.initials: I
authors.lastname: Baldeiras
authors.forename: Helena
authors.initials: H
authors.lastname: Ribeiro
authors.forename: Sónia
authors.initials: S
authors.lastname: Batista
authors.forename: Egídio
authors.initials: E
authors.lastname: Machado
authors.forename: Ana
authors.initials: A
authors.lastname: Maduro
authors.forename: Olinda
authors.initials: O
authors.lastname: Rebelo
authors.forename: Pedro
authors.initials: P
authors.lastname: Freitas
mesh_terms: D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D020645:Mediodorsal Thalamic Nucleus / Q000473:pathology*; D008875:Middle Aged; D020649:Pulvinar / Q000473:pathology*