title: miR-210: a therapeutic target in cancer.
abstract: BACKGROUND
  As the predominant miRNA regulated by hypoxia, miR-210 correlates with survival in cancer patients. miR-210 may play important roles in regulation of cell growth, angiogenesis and apoptosis in different human tumor models, indicating that it can be used as a therapeutic target.
  
  
  METHODS
  This review covers all literature related to miR-210 in malignant tumors from the past 5 years, and analyzes the biological functions and molecular mechanisms of it. The authors also envisage future developments toward the clinical applications of miR-210 to cancer diagnosis and treatment.
  
  
  CONCLUSIONS
  miR-210 may function as a new therapeutic target for anticancer intervention. Considering that the exact function of miR-210 is still not well characterized and understood, more investigations should be performed to promote the success of therapeutic-clinical use of miR-210 in cancer.
authors.affiliation: Fourth Military Medical University, Xijing Hospital of Digestive Diseases, Xijing Hospital, State Key Laboratory of Cancer Biology, Xi'an, 710032, Shaanxi Province, China. hongliu180@126.com
authors.forename: Liu
authors.initials: L
authors.lastname: Hong
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.forename: Qingchuan
authors.initials: Q
authors.lastname: Zhao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Qiao
mesh_terms: D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism
chemical_list: C543800:MIRN210 microRNA, human; D035683:MicroRNAs