title: Fingerprinting acute leukemia: DNA methylation profiling of B-acute lymphoblastic leukemia.
abstract: In this issue of Cancer Discovery, Geng and colleagues report on their use of a combination of promoter cytosine methylation profiling with gene expression and ChIP sequencing to elucidate molecular signatures of adult B-acute lymphoblastic leukemia patient samples with BCR-ABL1, E2A-PBX1, and MLL rearrangements. The unique epigenetic and gene expression signatures of these clinically unfavorable B-ALL subtypes identify novel biomarkers and provide a strong rationale for repurposing existing therapies to treat these molecularly distinct diseases.
authors.affiliation: Department of Pathology and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Luisa
authors.initials: L
authors.lastname: Cimmino
authors.forename: Iannis
authors.initials: I
authors.lastname: Aifantis
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D006801:Humans; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor