title: Association between CYP2C8 (rs1934951) polymorphism and bisphosphonate-related osteonecrosis of the jaws in patients on bisphosphonate therapy: a meta-analysis.
abstract: OBJECTIVE
  Bisphosphonate-related osteonecrosis of the jaws (BONJ) is a severe complication in patients on bisphosphonate therapy. The study was conducted to verify the association between CYP2C8 (rs1934951) polymorphism and BONJ predisposition.
  
  
  METHODS
  The relative epidemiologic studies were identified in PubMed and Embase to conduct a meta-analysis using STATA.
  
  
  RESULTS
  In the pooled analysis with multiple cancer types, patients carrying the CYP2C8 rs1934951 AA or AG genotype showed no significantly increased BONJ susceptibility compared with those carrying the wild GG genotype [dominant: odds ratio (OR) = 2.05, 95% confidence interval (CI) = 0.67-6.29, p = 0.209; recessive: OR = 1.88, 95% CI = 0.23-15.6, p = 0.560; AG vs. GG: OR = 2.07, 95% CI = 0.80-5.32, p = 0.133, and AA vs. GG: OR = 1.34, 95% CI = 0.48-3.74, p = 0.578]. A significant association between AA and AG genotypes of CYP2C8 (rs1934951) and BONJ risk was found in the subgroup analysis of multiple myeloma (dominant: OR = 5.77, 95% CI = 1.21-27.63, p = 0.028; AG vs. GG: OR = 5.02, 95% CI = 2.06-12.23, p = 0.001, and AA vs. GG: OR = 16.23, 95% CI = 1.72-78.7, p = 0.015).
  
  
  CONCLUSIONS
  The results indicated that AA and AG genotypes of CYP2C8 (rs1934951) might be predictors for multiple myeloma patients at high risk to develop BONJ.
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors.forename: Da-Ni
authors.initials: DN
authors.lastname: Zhong
authors.forename: Ji-Zhou
authors.initials: JZ
authors.lastname: Wu
authors.forename: Guo-Jian
authors.initials: GJ
authors.lastname: Li
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000235:genetics*; D065727:Cytochrome P-450 CYP2C8; D004164:Diphosphonates / Q000009:adverse effects*; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D004164:Diphosphonates; D001189:Aryl Hydrocarbon Hydroxylases; C450259:CYP2C8 protein, human; D065727:Cytochrome P-450 CYP2C8