title: The enigmatic root cell - emerging roles contributing to fluid homeostasis within the cochlear outer sulcus.
abstract: Despite their curious morphology prompting numerous hypotheses of their normal function, the root cells lining the cochlear outer sulcus have long evaded physiological characterization. A growing body of evidence now suggests that they regulate the solute content of the endolymph and/or the perilymph, and may be essential in safe-guarding the global homeostasis of the cochlea. Immuno-labeling experiments have demonstrated polarized expression of key ion transport proteins, and recent electrophysiological recordings have identified specific membrane conductances. These studies have painted a clearer picture of how this unusual cell type may contribute to the maintenance of sound transduction, and how they may be central to pathological processes associated with various forms of hearing loss. This article is part of a Special Issue entitled "Annual Reviews 2013".
authors.affiliation: Centre for Auditory Research, UCL Ear Institute, University College London, 332 Gray's Inn Road, London WC1X 8EE, UK. d.jagger@ucl.ac.uk
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Jagger
authors.forename: Andrew
authors.initials: A
authors.lastname: Forge
mesh_terms: D000818:Animals; D003051:Cochlea / Q000166:cytology* / Q000502:physiology*; D000072259:Connexin 26; D017630:Connexins; D004710:Endolymph / Q000502:physiology*; D017629:Gap Junctions / Q000502:physiology; D006309:Hearing / Q000502:physiology; D034381:Hearing Loss / Q000473:pathology / Q000503:physiopathology; D006706:Homeostasis; D006801:Humans; D017136:Ion Transport; D010498:Perilymph / Q000502:physiology*
chemical_list: D017630:Connexins; C000607042:GJB2 protein, human; D000072259:Connexin 26