title: Pilot clinical study of Sasa senanensis Rehder leaf extract treatment on lichenoid dysplasia.
abstract: BACKGROUND
  Previous studies have shown antiviral, antibacterial, and anti-inflammatory activity of alkaline extract of the leaves of Sasa senanensis Rehder (SE). Here, we investigated whether SE is effective on oral lichenoid dysplasia and osteoclastogenesis.
  
  
  METHODS
  A male patient with white lacy streaks in the oral mucosa was orally administered SE three times a day for 11 months. The area of white streaks was monitored by intraoral photography. Interleukin-6 and -8 in the saliva were determined by enzyme-linked immunosorbent assay. Osteoclastogenesis of mouse macrophage-like RAW264.7 cells, induced by receptor activator of nuclear factor-κB ligand (RANKL) was monitored by tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cell formation.
  
  
  RESULTS
  Long-term treatment with SE progressively reduced both the area of white steaks and the levels of salivary interleukin-6 and -8. SE significantly inhibited the macrophage differentiation towards osteoclasts.
  
  
  CONCLUSIONS
  The present study suggests the therapeutic potential of SE towards oral diseases.
authors.affiliation: Meikai Pharmaco-Medical Laboratory, Meikai University School of Dentistry, Sakado, Saitama, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Matsuta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakagami
authors.forename: Shoji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Mamoru
authors.initials: M
authors.lastname: Machino
authors.forename: Mineko
authors.initials: M
authors.lastname: Tomomura
authors.forename: Akito
authors.initials: A
authors.lastname: Tomomura
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yasui
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Itoh
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sugiura
authors.forename: Madoka
authors.initials: M
authors.lastname: Kitajima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Oizumi
authors.forename: Takaaki
authors.initials: T
authors.lastname: Oizumi
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D017676:Lichen Planus, Oral / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008264:Macrophages / Q000166:cytology; D008297:Male; D051379:Mice; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D053245:RANK Ligand / Q000378:metabolism; D012463:Saliva / Q000378:metabolism; D031787:Sasa / Q000737:chemistry; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D007527:Isoenzymes; D010936:Plant Extracts; D053245:RANK Ligand; D000135:Acid Phosphatase; C000605511:Acp5 protein, mouse; D000071681:Tartrate-Resistant Acid Phosphatase