title: Facile water promoted synthesis of 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids - highly potent antibacterial agents.
abstract: An elegant and efficient synthesis of hitherto novel 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids has been accomplished for the first time in a green solvent viz. water. The hybrid molecules exhibit significant antibacterial activity when screened against four human pathogens viz. Streptococcus pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi. In comparison to the commercially marketed tetracycline, some of them were equally potent and a few more potent.
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamilnadu, India.
authors.forename: Nagarajan
authors.initials: N
authors.lastname: Sangaraiah
authors.forename: Sathishkumar
authors.initials: S
authors.lastname: Murugan
authors.forename: Shanmugavelan
authors.initials: S
authors.lastname: Poovan
authors.forename: Ranganathan
authors.initials: R
authors.lastname: Raja
authors.forename: Ponnuswamy
authors.initials: P
authors.lastname: Alagusundaram
authors.forename: Venkatesan
authors.initials: V
authors.lastname: Ramakrishnan
authors.forename: Shanmugaiah
authors.initials: S
authors.lastname: Vellasamy
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012485:Salmonella typhi / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014867:Water / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D014230:Triazoles; D014867:Water; D000431:Ethanol