title: Schizophrenia patients with and without post-traumatic stress disorder (PTSD) have different mood symptom levels but same cognitive functioning.
abstract: OBJECTIVE
  To investigate differences in cognitive function and level of psychopathology in patients with schizophrenia (SZ) with or without psychological traumatization/post-traumatic stress disorder (PTSD). We hypothesized that traumatized patients with or without PTSD would have more severe cognitive impairments because of the neuropathological changes associated with PTSD, and more severe psychopathology compared with non-traumatized SZ patients.
  
  
  METHODS
  Seventy-five SZ patients with traumatization and 217 SZ patients without traumatization were evaluated regarding the symptoms and cognitive functioning, using standard symptom scales (PANSS; CDSS) and a neuropsychological test battery (IQ, verbal memory, attention, working memory, psychomotor speed, and executive functioning).
  
  
  RESULTS
  No significant differences were observed between the groups in cognitive test performance. The patients in the traumatized group with PTSD showed significantly more current depression than the non-traumatized group (P = 0.012).
  
  
  CONCLUSIONS
  The findings did not support the hypothesis that the presence of comorbid PTSD/traumatization in SZ is associated with increased cognitive impairment. The increase in current depression in SZ with comorbid traumatization suggests that more severe psychopathology is associated with traumatization.
authors.affiliation: Department of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. dawn.peleikis@vikenfiber.no
authors.forename: D E
authors.initials: DE
authors.lastname: Peleikis
authors.forename: M
authors.initials: M
authors.lastname: Varga
authors.forename: K
authors.initials: K
authors.lastname: Sundet
authors.forename: S
authors.initials: S
authors.lastname: Lorentzen
authors.forename: I
authors.initials: I
authors.lastname: Agartz
authors.forename: O A
authors.initials: OA
authors.lastname: Andreassen
mesh_terms: D000328:Adult; D000339:Affect; D000368:Aged; D001288:Attention; D016022:Case-Control Studies; D003071:Cognition; D003072:Cognition Disorders / Q000523:psychology*; D003863:Depression / Q000523:psychology*; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D011618:Psychotic Disorders / Q000523:psychology; D012559:Schizophrenia; D012565:Schizophrenic Psychology; D013313:Stress Disorders, Post-Traumatic / Q000523:psychology*; D055815:Young Adult