title: Bladder dysfunction changes from underactive to overactive after experimental traumatic brain injury.
abstract: Although bladder dysfunction is common after traumatic brain injury (TBI), few studies have investigated resultant bladder changes and the detailed relationship between TBI and bladder dysfunction. The goal of this study was to characterize the effects of TBI on bladder function in an animal model. Fluid-percussion injury was used to create an animal model with moderate TBI. Female Sprague-Dawley rats underwent TBI, sham TBI or were not manipulated (naïve). All rats underwent filling cystometry while bladder pressure and external urethral sphincter electromyograms were simultaneously recorded 1 day, 1 week, 2 weeks, and 1 month after injury. One day after injury, 70% of the animals in the TBI group and 29% of the animals in the sham TBI group showed no bursting activity during urination. Compared to naïve rats, bladder function was mainly altered 1 day and 1 week after sham TBI, suggesting the craniotomy procedure affected bladder function mostly in a temporary manner. Compared to either naïve or sham TBI, bladder weight was significantly increased 1 month after TBI and collagen in the bladder wall was increased. Bladder function in the TBI group went from atonic 1 day post-TBI to overactive 1 month post-TBI, suggesting that TBI significantly affected bladder function.
authors.affiliation: Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Hai-Hong
authors.initials: HH
authors.lastname: Jiang
authors.forename: Olga N
authors.initials: ON
authors.lastname: Kokiko-Cochran
authors.forename: Kevin
authors.initials: K
authors.lastname: Li
authors.forename: Brian
authors.initials: B
authors.lastname: Balog
authors.forename: Ching-Yi
authors.initials: CY
authors.lastname: Lin
authors.forename: Margot S
authors.initials: MS
authors.lastname: Damaser
authors.forename: Vernon
authors.initials: V
authors.lastname: Lin
authors.forename: Julian Yaoan
authors.initials: JY
authors.lastname: Cheng
authors.forename: Yu-Shang
authors.initials: YS
authors.lastname: Lee
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology*; D004195:Disease Models, Animal; D004576:Electromyography / Q000379:methods; D005260:Female; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology; D009929:Organ Size / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014521:Urethra / Q000502:physiology; D001743:Urinary Bladder / Q000294:innervation / Q000503:physiopathology; D001750:Urinary Bladder, Neurogenic / Q000209:etiology / Q000503:physiopathology*; D053201:Urinary Bladder, Overactive / Q000209:etiology / Q000503:physiopathology*; D014563:Urodynamics / Q000502:physiology*