title: Vitamin D receptor gene polymorphism and cardiovascular risk variables in elderly Polish subjects.
abstract: The aim of this work was to evaluate whether the FokI and BsmI polymorphisms of the VDR gene are associated with anthropometric and biochemical features of cardiovascular disease (CVD) in a Caucasian population aged over 65, participants of the Polish PolSenior study. We performed the study on randomly selected subjects: 427 women and 454 men aged over 65. Measurements of anthropometric parameters were carried out and biochemical parameters were estimated using commercial kits. VDR polymorphisms (rs10735810, rs1544410) were genotyped by PCR and FRLP. The prevalence of BsmI genotypes was 50% Bb, 23% bb, 27% BB in women and 48% Bb, 20% bb, 32% BB in men. The prevalence of FokI was 48% Ff, 22% ff, 30% FF in women and 50% Ff, 18% ff, 32% FF in men. The women bearing the rare allele b differ in homeostatic model assessment (HOMA) (p < 0.049) from women bearing common allele B, and the men differ in insulin level (p < 0.047) and HOMA (p < 0.017). There were no significant differences in anthropometric or biochemical parameters between genotypes in FokI in female and male groups. The common allele B is connected with biochemical risk factors of CVD in older Caucasian men and women.
authors.affiliation: Department of Endocrinology and Diabetology, Wroclaw Medical University, Wroclaw, Poland. lukasz.laczmanski@am.wroc.pl
authors.forename: Lukasz
authors.initials: L
authors.lastname: Laczmanski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Milewicz
authors.forename: Felicja
authors.initials: F
authors.lastname: Lwow
authors.forename: Monika
authors.initials: M
authors.lastname: Puzianowska-Kuznicka
authors.forename: Maurycy
authors.initials: M
authors.lastname: Pawlak
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kolackov
authors.forename: Diana
authors.initials: D
authors.lastname: Jedrzejuk
authors.forename: Barbara
authors.initials: B
authors.lastname: Krzyzanowska-Swiniarska
authors.forename: Ewa
authors.initials: E
authors.lastname: Bar-Andziak
authors.forename: Jerzy
authors.initials: J
authors.lastname: Chudek
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Mossakowska
mesh_terms: D050154:Adiposity; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D006949:Hyperlipidemias / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000473:pathology; D008297:Male; D009765:Obesity / Q000473:pathology / Q000503:physiopathology; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D012727:Sex Characteristics
chemical_list: D007328:Insulin; D018167:Receptors, Calcitriol; C579457:VDR protein, human