title: Kinetic modeling of fermentative production of 1, 3-propanediol by Klebsiella pneumoniae HR526 with consideration of multiple product inhibitions.
abstract: During the fermentative production of 1, 3-propanediol (1,3-PD), the multiple product inhibitions cannot be negligible to accurately describe the kinetics of fermentation process. A kinetic model for fermentative production of 1,3-PD by Klebsiella pneumoniae HR526 with glycerol as carbon source under aerobic condition was proposed. The inhibitions of multiple products including 1,3-PD, 2, 3-butanediol (2,3-BD), acetate, and succinate were considered in the model. It was found that 1,3-PD, 2,3-BD, and acetate showed strong inhibitions to cell growth depending on their concentrations. The kinetic model was relatively accurate to predict the experimental data of batch, fed-batch, and continuous fermentations. The model thus can serve as a tool for further controlling and optimizing the fermentation process.
authors.affiliation: Institute of Applied Chemistry, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
authors.forename: Lu
authors.initials: L
authors.lastname: He
authors.forename: Xuebing
authors.initials: X
authors.lastname: Zhao
authors.forename: Keke
authors.initials: K
authors.lastname: Cheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Dehua
authors.initials: D
authors.lastname: Liu
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology; D002072:Butylene Glycols / Q000494:pharmacology; D005285:Fermentation; D007700:Kinetics; D007711:Klebsiella pneumoniae / Q000737:chemistry* / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D008956:Models, Chemical; D011409:Propylene Glycols / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002072:Butylene Glycols; D011409:Propylene Glycols; D019342:Acetic Acid