title: XPD and XRCC1 gene polymorphism in patients with normal and abnormal cervical cytology by pap smear.
abstract: OBJECTIVE
  The purpose of the present study was to identify the role of abnormalities in DNA repair pathways by measuring the XPD and XRCC1 gene polymorphisms.
  
  
  METHODS
  Thirty-five patients with abnormal cervical cytology (study group) and 10 women with normal cytology (control group) were included in the study. The polymorphisms of XRCC1 Arg194Trp, XRCC1 Arg399Gln and XPD Lys751Gln genes were investigated from the blood samples.
  
  
  RESULTS
  There was no statistically significant difference in allele frequencies of XPD gene among the groups (p = 0.097), while XRCC1R399Q gene polymorphism was strikingly more frequent in the study group than that of control cases (p = 0.029). The prevalence of XRCC1R194W gene polymorphism on the other hand, was similar between the groups (p = 0.579).
  
  
  CONCLUSIONS
  Patients with abnormal and normal cervical cytology have similar XPD gene polymorphism. However, the frequency of gene polymorphism in XRCC1 Arg 399 Gln codon was significantly higher in abnormal cervical cytology group.
authors.affiliation: Turgut Ozal Medical Center, Malatya, Turkey. ercanyilmazgyn@yahoo.com
authors.forename: E
authors.initials: E
authors.lastname: Yilmaz
authors.forename: O
authors.initials: O
authors.lastname: Celik
authors.forename: E
authors.initials: E
authors.lastname: Celik
authors.forename: I
authors.initials: I
authors.lastname: Turkcuoglu
authors.forename: Y
authors.initials: Y
authors.lastname: Simsek
authors.forename: A
authors.initials: A
authors.lastname: Karaer
authors.forename: B
authors.initials: B
authors.lastname: Otlu
authors.forename: G
authors.initials: G
authors.lastname: Gulbay
authors.forename: E
authors.initials: E
authors.lastname: Yesilada
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D061809:Human Papillomavirus DNA Tests / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D065006:Papanicolaou Test; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000821:virology*; D014626:Vaginal Smears; D000076105:X-ray Repair Cross Complementing Protein 1; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D051759:Xeroderma Pigmentosum Group D Protein