title: Portal hypertension: effect of early splenic artery ligation on platelets count during splenectomy.
abstract: OBJECTIVE
  Hypersplenism due to splenic congestion is observed in portal hypertensive patients. This study was done to know the change in platelets count following early ligation of splenic artery during splenectomy in patients with thrombocytopenia due to portal hypertension with a hypothesis that splenic decongestion results in increased platelets count; thereby platelet transfusion can be avoided.
  
  
  METHODS
  Patients with platelets count <100,000 per mm(3) due to portal hypertension were involved and we followed a protocol of ligating splenic artery first, followed by 30 minutes waiting period for splenic decongestion. Blood sample was collected at 5 and 30 minutes for the estimation of platelets count.
  
  
  RESULTS
  Significant rise in platelets was observed after 5 and 30 minutes of early ligation of splenic artery with mean rise being 23735 ± 15417 and 35085 ± 20458 per mm(3), respectively. The rise in platelets at 30 minutes was significant when compared with 5 minutes rise with mean platelets count being 91661 and 103070 per mm(3) at 5 and 30 minutes, respectively. The platelets rise was equal to 4 and 6 units of platelets concentrates, respectively.
  
  
  CONCLUSIONS
  Early ligation of splenic artery during splenectomy for portal hypertension results in significant rise in platelets after 5 and 30 minutes. This method conserves platelets and avoids platelets transfusion and its complications.
authors.affiliation: Department of Surgical Gastroenterology, Smt. NHL Municipal Medical College, Ahmedabad, India.
authors.forename: Mahendra S
authors.initials: MS
authors.lastname: Bhavsar
authors.forename: Hasmukh B
authors.initials: HB
authors.lastname: Vora
authors.forename: Lakshman S
authors.initials: LS
authors.lastname: Khiria
authors.forename: Venugopal H
authors.initials: VH
authors.lastname: Giriyappa
mesh_terms: D000328:Adult; D006801:Humans; D006971:Hypersplenism / Q000097:blood / Q000150:complications* / Q000601:surgery; D006975:Hypertension, Portal / Q000097:blood / Q000150:complications* / Q000601:surgery; D007432:Intraoperative Period; D008026:Ligation / Q000379:methods; D010976:Platelet Count; D013156:Splenectomy / Q000379:methods*; D013157:Splenic Artery / Q000601:surgery*; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome