title: Absence of p53 gene mutations in exons 5 - 7 among breast cancer patients of Bengalee Hindu caste females, West Bengal, India.
abstract: BACKGROUND
  The high incidence and relatively good prognosis of breast cancer has made it the most prevalent cancer in the world today. A large number of distinct mutations and polymorphisms in the p53 gene have been reported worldwide, but there is no report regarding the role of this inherited susceptibility gene in breast cancer risk among the Bengalee Hindu Caste females of West Bengal, India.
  
  
  OBJECTIVE
  We investigated the distribution and the nature of p53 gene mutations and polymorphisms in exons 5-7 in a cohort of 110 Bengalee Hindu breast cancer patients and 127 age, sex and caste matched controls by direct sequencing.
  
  
  RESULTS
  We did not observe any mutations and polymorphisms in our studied individuals.
  
  
  CONCLUSIONS
  We therefore conclude that mutations in exons 5-7 of p53 gene are rare causes of breast cancer among Bengalee Hindu caste females, and therefore of little help for genetic counseling and diagnostic purposes.
authors.affiliation: Anthropological Survey of India, India. brcres.anthro@gmail.com
authors.forename: Abhishikta Ghosh
authors.initials: AG
authors.lastname: Roy
authors.forename: Bn
authors.initials: B
authors.lastname: Sarkar
authors.forename: Rakesh
authors.initials: R
authors.lastname: Roy
authors.forename: Vr
authors.initials: V
authors.lastname: Rao
authors.forename: Ar
authors.initials: A
authors.lastname: Bandyopadhyay
mesh_terms: D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D002277:Carcinoma / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D009154:Mutation; D011110:Polymorphism, Genetic; D012923:Social Class; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53