title: Differential assembly of GPCR signaling complexes determines signaling specificity.
abstract: Recent proteomic and biochemical evidence indicates that cellular -signaling is organized in protein modules. G protein-coupled receptors (GPCRs) are privileged entry points for extracellular signals that are transmitted through the plasma membrane into the cell. The adequate cellular response and signaling specificity is regulated by GPCR-associated protein modules. The composition of these modules is dynamic and might depend on receptor stimulation, the proteome of a given cellular context, the subcellular localization of receptor-associated modules, the formation of GPCR oligomers and the variation of expression levels of components of these modules under physiological, for example circadian rhythm, or pathological conditions. The current article will highlight the importance of GPCR-associated protein modules as a biochemical basis for signaling specificity.
authors.affiliation: Inserm, U1016, Institut Cochin, 22 rue Méchain, 75014, Paris, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Maurice
authors.forename: Abla
authors.initials: A
authors.lastname: Benleulmi-Chaachoua
authors.forename: Ralf
authors.initials: R
authors.lastname: Jockers
mesh_terms: D000818:Animals; D006801:Humans; D055503:Protein Multimerization; D021381:Protein Transport; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D043562:Receptors, G-Protein-Coupled