title: Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles.
abstract: Current ovarian cancer treatments based on surgery/chemotherapy show limited efficacy. Targeting immunosuppression is a requirement for the effectiveness of novel promising anti-tumor immunotherapies. Our latest work in preclinical models shows that nanoparticle-mediated delivery of immunostimulatory microRNAs specifically to tumor-associated leukocytes is sufficient to re-program immunological control of metastatic ovarian cancers.
authors.affiliation: Department of Medicine; Weill Cornell Medical College; New York, NY USA ; The Ragon Institute of MGH; MIT and Harvard; Charlestown, MA USA.
authors.forename: Juan R
authors.initials: JR
authors.lastname: Cubillos-Ruiz
authors.forename: Lorenzo F
authors.initials: LF
authors.lastname: Sempere
authors.forename: Jose R
authors.initials: JR
authors.lastname: Conejo-Garcia