title: Clinical correlation of mesenteric vascular disease in older patients.
abstract: Mesenteric vascular obstruction is difficult to characterize, since it may produce differing acute or chronic clinical pictures and various organic symptoms, such as ischemic colitis and abdominal angina. The diagnosis of chronic mesenteric ischemia (CMI) is thus still mainly based on historic diagnostic criteria drawn up before non-invasive radiological imaging of the mesenteric vessels became widespread, and before the current demographic developments leading to a rise in the number of older patients with multiple pathologies. With this premise, we studied the clinical condition of 85 patients aged over 65 years of age, submitted to angio-CT scan for reasons other than neoplastic and general pathologies which may cause alterations in mesenteric blood flow, and without the typical symptoms of acute intestinal ischemia. Of these, 34 patients presented occlusion of at least one mesenteric vessel and 13 were affected by multivessel injury. Compared with controls, patients with mesenteric artery disease had lower BMI (24.9+/-3.3 vs 26.8+/-4.5) and longer hospital stays (14 vs 6 days), and were more frequently affected by vasculopathies in other districts (97.1% vs 80.4%), but the only bowel symptom present was diarrhea (21.2% vs 5.9%). These patients also took more benzodiazepines and acetylsalicylic acid. The results of stepwise logistic analysis of length of hospital stay, vasculopathies, diarrhea, and use of benzodiazepines yielded a predictive model with an AUC (area under the curve) of 0.81. Our data show that some features characterizing CMI in the geriatric population differ from those of the general population.
authors.affiliation: Department of Surgical and Gastroenterological Sciences, University of Padova Hospital, Padova, Italy. fabrizio.cardin@sanita.padova.it
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Cardin
authors.forename: Stefania
authors.initials: S
authors.lastname: Fratta
authors.forename: Egle
authors.initials: E
authors.lastname: Perissinotto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Casarrubea
authors.forename: Emine Meral
authors.initials: EM
authors.lastname: Inelmen
authors.forename: Claudio
authors.initials: C
authors.lastname: Terranova
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sergi
authors.forename: Carmelo
authors.initials: C
authors.lastname: Militello
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D007422:Intestines / Q000098:blood supply / Q000503:physiopathology; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D008638:Mesenteric Arteries / Q000503:physiopathology*; D065666:Mesenteric Ischemia; D008643:Mesentery / Q000098:blood supply* / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000502:physiology; D014652:Vascular Diseases / Q000503:physiopathology*