title: The challenging trisomy 16: a case report.
abstract: BACKGROUND
  Trisomy 16 is a very frequent autosomal anomaly accounting for about 2% of first trimester abortions. In most pregnancies the chromosomal genome found in the fetus is also present in the placenta. Confined placental mosaicism is frequently detected in the placental region along with a structurally normal fetus.
  
  
  METHODS
  We present the case of a 39-year-old primigravida with confined placental mosaicism diagnosed with chorionic villus sampling. Amniocentesis showed a normal karyotype (46, XX). Detailed scanning revealed no structural fetal anomalies, but severe oligohydramnios.
  
  
  CONCLUSIONS
  Diagnosis of trisomy 16 does not necessarily mean that the newborn has anatomical abnormalities.
authors.affiliation: Department of Obstetrics & Gynaecology, Democritus, University, Alexandroupolis, Greece. mek-2@otenet.gr
authors.forename: E N
authors.initials: EN
authors.lastname: Kontomanolis
authors.forename: M
authors.initials: M
authors.lastname: Lambropoulou
authors.forename: A
authors.initials: A
authors.lastname: Georgiadis
authors.forename: I
authors.initials: I
authors.lastname: Gramatikopoulou
authors.forename: T H
authors.initials: TH
authors.lastname: Deftereou
authors.forename: G
authors.initials: G
authors.lastname: Galazios
mesh_terms: D000328:Adult; D000649:Amniocentesis; D015193:Chorionic Villi Sampling; D025063:Chromosome Disorders / Q000175:diagnosis; D002885:Chromosomes, Human, Pair 16; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D009030:Mosaicism; D016104:Oligohydramnios / Q000000981:diagnostic imaging; D010920:Placenta / Q000737:chemistry; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D014314:Trisomy / Q000175:diagnosis*; D014463:Ultrasonography