title: Aerosol transmission of chronic wasting disease in white-tailed deer.
abstract: While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of CWD to deer with a prion dose >20-fold lower than that used in previous oral inoculations. Inhalation of prions may facilitate transmission of CWD and, perhaps, other prion infections.
authors.affiliation: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.
authors.forename: Nathaniel D
authors.initials: ND
authors.lastname: Denkers
authors.forename: Jeanette
authors.initials: J
authors.lastname: Hayes-Klug
authors.forename: Kelly R
authors.initials: KR
authors.lastname: Anderson
authors.forename: Davis M
authors.initials: DM
authors.lastname: Seelig
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Haley
authors.forename: Sallie J
authors.initials: SJ
authors.lastname: Dahmes
authors.forename: David A
authors.initials: DA
authors.lastname: Osborn
authors.forename: Karl V
authors.initials: KV
authors.lastname: Miller
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Warren
authors.forename: Candace K
authors.initials: CK
authors.lastname: Mathiason
authors.forename: Edward A
authors.initials: EA
authors.lastname: Hoover
mesh_terms: D000336:Aerosols; D000818:Animals; D003670:Deer; D001239:Inhalation; D034081:Wasting Disease, Chronic / Q000635:transmission*
chemical_list: D000336:Aerosols