title: Proteasome inhibition in transplantation-focusing on the experience with bortezomib.
abstract: The proteasome inhibition has been proved to be effective in the treatment of multiple myeloma and other malignancies. In addition to direct antitumor effects, proteasome inhibition also exerts strong effects on immune cells, such as T cells, B cells and DCs. Therefore, proteasome inhibition, through the utilization of small molecule drugs like bortezomib, could be used therapeutically to modulate immune responses in transplantation. In the current review, we discuss the emerging data, both preclinical and clinical, of using proteasome inhibition in treating complications of transplantation, such as antibody-mediated organ rejection (AMR) and graft-versus-host disease (GVHD). The therapy based on proteasome inhibition may present substantial opportunities as new therapeutic paradigms in transplantation.
authors.affiliation: Laboratory of Cellular and Molecular Tumor Immunology, Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liang
authors.forename: Haiyan
authors.initials: H
authors.lastname: Liu
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D001897:Boronic Acids / Q000494:pharmacology / Q000627:therapeutic use; D000069286:Bortezomib; D003713:Dendritic Cells / Q000276:immunology; D015195:Drug Design; D006084:Graft Rejection / Q000188:drug therapy / Q000276:immunology; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D016377:Organ Transplantation / Q000379:methods*; D061988:Proteasome Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011719:Pyrazines / Q000494:pharmacology / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000906:Antibodies; D001897:Boronic Acids; D061988:Proteasome Inhibitors; D011719:Pyrazines; D000069286:Bortezomib