title: The correlations of LMX1A and osteopontin expression to the clinicopathologic stages in pancreatic adenocarcinoma.
abstract: OBJECTIVE
  To test the association of LMX1A and osteopontin (OPN) expression with histologic differentiation or pathologic stage in pancreatic ductal adenocarcinoma.
  
  
  METHODS
  Immunohistochemical analysis was performed to determine LMX1A and OPN expression in 100 surgical specimens obtained from Chinese patients with well-differentiated (n=15), moderately differentiated (n=65), and poorly differentiated (n=20) pancreatic ductal adenocarcinomas.
  
  
  RESULTS
  LMX1A and OPN immunoreactivities were undetectable in normal pancreatic glandular epithelia. Stronger immunostaining for LMX1A and OPN was associated with advanced nuclear grades of pancreatic ductal adenocarcinomas (70.7 and 87.1 for grade I, 109.8 and 118.3 for grade II, and 171.3 and 183.8 for grade III), and advanced TNM and American Joint Committee on Cancer stages of pancreatic ductal adenocarcinomas.
  
  
  CONCLUSIONS
  A higher expression of LMX1A and OPN is well correlated with histologic grade and pathologic stage of pancreatic ductal adenocarcinomas.
authors.affiliation: Departments of *Pathology †Internal Medicine, National Defense Medical Center, Division of Infectious Diseases and Tropical Medicine ‡Surgery, National Defense Medical Center, Division of General Surgery, Tri-Service General Hospital, Taipei §Health Center of Don-Shan township of Yilan County, Yilan ∥Department of Pathology, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Wen-Chiuan
authors.initials: WC
authors.lastname: Tsai
authors.forename: Chih-Kung
authors.initials: CK
authors.lastname: Lin
authors.forename: Ya-Sung
authors.initials: YS
authors.lastname: Yang
authors.forename: De-Chuan
authors.initials: DC
authors.lastname: Chan
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Gao
authors.forename: Fei-Ni
authors.initials: FN
authors.lastname: Chang
authors.forename: Jong-Shiaw
authors.initials: JS
authors.lastname: Jin
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D060850:LIM-Homeodomain Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D053495:Osteopontin / Q000378:metabolism*; D010179:Pancreas / Q000276:immunology / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016612:Paraffin Embedding; D046888:Tissue Array Analysis; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D060850:LIM-Homeodomain Proteins; C078021:LMX1A protein, human; D014157:Transcription Factors; D053495:Osteopontin