title: Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study.
abstract: A number of single nucleotide polymorphisms (SNP) have been linked to higher risk of venous thromboembolism (VTE). We investigated the VTE risk associated with SNPs in the GP6 (rs1613662), SERPINC1 (rs2227589), F11 (rs2036914 and rs2289252), FGG (rs2066865), and F12 (rs1801020) genes. In F11, the CC genotype for rs2036914 and the CT and TT genotypes for rs2289252 were associated with a significantly higher VTE risk. A trend toward a thrombogenic effect was observed for the risk alleles of the GP6 and FGG SNPs. Risk estimates were unaffected by adjustments for blood type and F5 rs6025 (Factor V Leiden) mutation.
authors.affiliation: Department of Haematology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.
authors.forename: Tarec C
authors.initials: TC
authors.lastname: El-Galaly
authors.forename: Marianne T
authors.initials: MT
authors.lastname: Severinsen
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Rudi
authors.initials: R
authors.lastname: Steffensen
authors.forename: Anders K
authors.initials: AK
authors.lastname: Vistisen
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Søren R
authors.initials: SR
authors.lastname: Kristensen
mesh_terms: D000990:Antithrombin III / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics; D015331:Cohort Studies; D003718:Denmark; D005174:Factor XII / Q000235:genetics; D005338:Fibrin Fibrinogen Degradation Products / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D010980:Platelet Membrane Glycoproteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000235:genetics; D012307:Risk Factors; D020246:Venous Thrombosis / Q000097:blood / Q000235:genetics*
chemical_list: D015815:Cell Adhesion Molecules; C407243:F11R protein, human; D005338:Fibrin Fibrinogen Degradation Products; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; C542513:SERPINC1 protein, human; C098341:platelet membrane glycoprotein VI; C031564:fibrinogen (gamma 95-264); D000990:Antithrombin III; D005174:Factor XII