title: Plasma long pentraxin 3 (PTX3) concentration is a novel marker of disease activity in patients with community-acquired pneumonia.
abstract: BACKGROUND
  Long pentraxin 3 (PTX3) is an acute-phase protein secreted by various cells, including leukocytes and endothelial cells. Like C-reactive protein (CRP), it belongs to the pentraxin superfamily. The aim of this study was to investigate the differential changes in plasma levels of PTX3 between before and after antibiotic treatment in hospitalized adult patients with community-acquired pneumonia (CAP).
  
  
  METHODS
  Plasma PTX3 levels were measured in 61 adult patients with CAP and 60 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, APACHE II, CURB-65, and pneumonia severity index (PSI) scores were determined to assess CAP severity in patients.
  
  
  RESULTS
  The results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of CRP and PTX3 observed after antibiotic treatment. The plasma concentration of PTX3, but not CRP, was correlated with the severity of CAP based on the PSI (r=0.290, p=0.023), CURB-65 (r=0.312, p=0.015), and APACHE II scores (r=0.427, p=0.001). The PTX3 level also exhibited a significant correlation with the length of hospital stay (r=0.500, p<0.0001).
  
  
  CONCLUSIONS
  PTX3 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.
authors.affiliation: Department of Chest Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, and School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan.
authors.forename: Shang-Jyh
authors.initials: SJ
authors.lastname: Kao
authors.forename: Hui-Wen
authors.initials: HW
authors.lastname: Yang
authors.forename: Shih-Ming
authors.initials: SM
authors.lastname: Tsao
authors.forename: Chao-Wen
authors.initials: CW
authors.lastname: Cheng
authors.forename: Mauo-Ying
authors.initials: MY
authors.lastname: Bien
authors.forename: Ming-Chih
authors.initials: MC
authors.lastname: Yu
authors.forename: Kuan-Jen
authors.initials: KJ
authors.lastname: Bai
authors.forename: Shun-Fa
authors.initials: SF
authors.lastname: Yang
authors.forename: Ming-Hsien
authors.initials: MH
authors.lastname: Chien
mesh_terms: D018806:APACHE; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D017714:Community-Acquired Infections / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007902:Length of Stay; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D011014:Pneumonia / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D000683:Serum Amyloid P-Component / Q000032:analysis*; D012720:Severity of Illness Index; D000099153:Pentraxins
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins