title: Saw palmetto ethanol extract inhibits adipocyte differentiation.
abstract: The fruits of saw palmetto have been used for the treatment of a variety of urinary and reproductive system problems. In this study we investigated whether the fruit extracts affect in vitro adipogenesis. Saw palmetto ethanol extract inhibited the lipid droplet accumulation by induction media in a dose-dependent manner, and it also attenuated the protein expressions of C-EBPα and PPARγ. Phosphorylation of Erk1/2 and Akt1 were also decreased by saw palmetto ethanol extract. This report suggests that saw palmetto extracts selectively affect the adipocyte differentiation through the modulation of several key factors that play a critical role during adipogenesis.
authors.affiliation: Department of Biological Sciences, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Villaverde
authors.forename: Adriana
authors.initials: A
authors.lastname: Galvis
authors.forename: Adriana
authors.initials: A
authors.lastname: Marcano
authors.forename: Horacio A
authors.initials: HA
authors.lastname: Priestap
authors.forename: Bradley C
authors.initials: BC
authors.lastname: Bennett
authors.forename: M Alejandro
authors.initials: MA
authors.lastname: Barbieri
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism; D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D005638:Fruit; D051379:Mice; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D010766:Phosphorylation; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D028024:Serenoa / Q000737:chemistry*; D015398:Signal Transduction / Q000187:drug effects; D012997:Solvents / Q000737:chemistry
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C530718:CEBPA protein, mouse; D047495:PPAR gamma; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; C514862:Akt1 protein, mouse; D051057:Proto-Oncogene Proteins c-akt; C535148:Mapk1 protein, mouse; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; C040972:saw palmetto extract