title: Perceptual convergence of multi-component mixtures in olfaction implies an olfactory white.
abstract: In vision, two mixtures, each containing an independent set of many different wavelengths, may produce a common color percept termed "white." In audition, two mixtures, each containing an independent set of many different frequencies, may produce a common perceptual hum termed "white noise." Visual and auditory whites emerge upon two conditions: when the mixture components span stimulus space, and when they are of equal intensity. We hypothesized that if we apply these same conditions to odorant mixtures, "whiteness" may emerge in olfaction as well. We selected 86 molecules that span olfactory stimulus space and individually diluted them to a point of about equal intensity. We then prepared various odorant mixtures, each containing various numbers of molecular components, and asked human participants to rate the perceptual similarity of such mixture pairs. We found that as we increased the number of nonoverlapping, equal-intensity components in odorant mixtures, the mixtures became more similar to each other, despite not having a single component in common. With ~30 components, most mixtures smelled alike. After participants were acquainted with a novel, arbitrarily named mixture of ~30 equal-intensity components, they later applied this name more readily to other novel mixtures of ~30 equal-intensity components spanning stimulus space, but not to mixtures containing fewer components or to mixtures that did not span stimulus space. We conclude that a common olfactory percept, "olfactory white," is associated with mixtures of ~30 or more equal-intensity components that span stimulus space, implying that olfactory representations are of features of molecules rather than of molecular identity.
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. tali.weiss@weizmann.ac.il
authors.forename: Tali
authors.initials: T
authors.lastname: Weiss
authors.forename: Kobi
authors.initials: K
authors.lastname: Snitz
authors.forename: Adi
authors.initials: A
authors.lastname: Yablonka
authors.forename: Rehan M
authors.initials: RM
authors.lastname: Khan
authors.forename: Danyel
authors.initials: D
authors.lastname: Gafsou
authors.forename: Elad
authors.initials: E
authors.lastname: Schneidman
authors.forename: Noam
authors.initials: N
authors.lastname: Sobel
mesh_terms: D000328:Adult; D045424:Complex Mixtures / Q000737:chemistry*; D004192:Discrimination, Psychological / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009812:Odorants; D055696:Olfactory Perception / Q000502:physiology*; D012903:Smell / Q000502:physiology*; D018709:Statistics, Nonparametric; D013268:Stimulation, Chemical
chemical_list: D045424:Complex Mixtures