title: Hypervalent iodine catalyzed Hofmann rearrangement of carboxamides using oxone as terminal oxidant.
abstract: Hofmann rearrangement of carboxamides to carbamates using Oxone as an oxidant can be efficiently catalyzed by iodobenzene. This reaction involves hypervalent iodine species generated in situ from catalytic amount of PhI and Oxone in the presence of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) in aqueous methanol solutions. Under these conditions, Hofmann rearrangement of various carboxamides affords corresponding carbamates in high yields.
authors.affiliation: Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, Minnesota 55812, USA. ayoshimu@d.umn.edu
authors.forename: Akira
authors.initials: A
authors.lastname: Yoshimura
authors.forename: Kyle R
authors.initials: KR
authors.lastname: Middleton
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Luedtke
authors.forename: Chenjie
authors.initials: C
authors.lastname: Zhu
authors.forename: Viktor V
authors.initials: VV
authors.lastname: Zhdankin