title: Quantification of terbinafine in pharmaceutical tablets using capillary electrophoresis with contactless conductivity detection and batch injection analysis with amperometric detection.
abstract: Terbinafine hydrochloride (TerbHCl) is an allylamine derivative with fungicidal action, especially against dermatophytes. Different analytical methods have been reported for quantifying TerbHCl in different samples. These procedures require time-consuming sample preparation or expensive instrumentation. In this paper, electrochemical methods involving capillary electrophoresis with contactless conductivity detection, and amperometry associated with batch injection analysis, are described for the determination of TerbHCl in pharmaceutical products. In the capillary electrophoresis experiments, terbinafine was protonated and analyzed in the cationic form in less than 1 min. A linear range from 1.46 to 36.4 μg mL(-1) in acetate buffer solution and a detection limit of 0.11 μg mL(-1) were achieved. In the amperometric studies, terbinafine was oxidized at +0.85 V with high throughput (225 injection h(-1)) and good linear range (10-100 μmol L(-1)). It was also possible to determine the antifungal agent using simultaneous conductometric and potentiometric titrations in the presence of 5% ethanol. The electrochemical methods were applied to the quantification of TerbHCl in different tablet samples; the results were comparable with values indicated by the manufacturer and those found using titrimetry according to the Pharmacopoeia. The electrochemical methods are simple, rapid and an appropriate alternative for quantifying this drug in real samples.
authors.affiliation: Universidade de São Paulo-Instituto de Química-Av. Prof. Lineu Prestes, 748CEP 05508-000-São Paulo-SP-Brazil.
authors.forename: Fabiana S
authors.initials: FS
authors.lastname: Felix
authors.forename: Luís M C
authors.initials: LM
authors.lastname: Ferreira
authors.forename: Pamela de O
authors.initials: Pde O
authors.lastname: Rossini
authors.forename: Claudimir L
authors.initials: CL
authors.lastname: do Lago
authors.forename: Lúcio
authors.initials: L
authors.lastname: Angnes
mesh_terms: D004553:Electric Conductivity; D055664:Electrochemical Techniques; D019075:Electrophoresis, Capillary / Q000379:methods*; D057230:Limit of Detection; D009281:Naphthalenes / Q000032:analysis*; D012015:Reference Standards; D013607:Tablets; D000077291:Terbinafine
chemical_list: D009281:Naphthalenes; D013607:Tablets; D000077291:Terbinafine