title: The expression and distribution of α-Gal gene in various species ocular surface tissue.
abstract: OBJECTIVE
  To examine the α-Gal gene expression and distribution in the different species/genus and developing phase animal ocular surface tissue.
  
  
  METHODS
  α-Gal binding assay were carried out on various animal eye sections. Photograph, slit-lamp observation on various eye showed normal corneal transparence.
  
  
  RESULTS
  A strong α-Gal expression in invertebrates and some vertebrates ocular tissue, but no α-Gal binding in birds, fish and mammal. α-Gal expression change in the development of mice ocular surface tissue (except sclera) and display genus dependency in the different murine ocular surface tissue.
  
  
  CONCLUSIONS
  This study identified specific α-Gal epitopes binding area in the ocular surface of several species and may solve the problem that naive ocular surface may be used as natural α-Gal gene knockout model/high risk immunologic rejection model or ocular surface scaffold material.
authors.affiliation: Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shao
authors.forename: Yao
authors.initials: Y
authors.lastname: Yu
authors.forename: Chong-Gang
authors.initials: CG
authors.lastname: Pei
authors.forename: Yangluowa
authors.initials: Y
authors.lastname: Qu
authors.forename: Gui-Ping
authors.initials: GP
authors.lastname: Gao
authors.forename: Ji-Lin
authors.initials: JL
authors.lastname: Yang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhou
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.forename: Qiu-Ping
authors.initials: QP
authors.lastname: Liu