title: Electrospinning of carboxyethyl chitosan/poly(vinyl alcohol)/silk fibroin nanoparticles for wound dressings.
abstract: Composite nanofibrous membranes of water-soluble N-carboxyethyl chitosan/poly(vinyl alcohol)/silk fibroin nanoparticles were successfully fabricated by electrospinning. The composite nanofibers were subjected to detailed analysis by scanning electron microscopy (SEM), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). SEM results investigated that the morphology and diameter of the nanofibers were affected by silk fibroin nanoparticles content. XRD and DSC demonstrated that there was intermolecular hydrogen bonding among the molecules of carboxyethyl chitosan, silk fibroin and PVA. The crystalline microstructure of the electrospun fibers was not well developed. The indirect cytotoxicity assessments of the nanofibers were studied. The result showed the nanofibers had good biocompatibility. This novel electrospun matrix would be used as potential wound dressing for skin regeneration.
authors.affiliation: College of Materials Science and Engineering, Wuhan Textile University, Wuhan 430073, People's Republic of China. zyssyz@126.com
authors.forename: Yingshan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Hongjun
authors.initials: H
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Mao
authors.forename: Shaojin
authors.initials: S
authors.lastname: Gu
authors.forename: Weilin
authors.initials: W
authors.lastname: Xu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002460:Cell Line; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry; D003460:Crystallization; D005349:Fibroins / Q000737:chemistry*; D008567:Membranes, Artificial; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry / Q000633:toxicity / Q000648:ultrastructure; D057139:Nanofibers / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D009779:Occlusive Dressings; D010316:Particle Size; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012995:Solubility; D054457:Tissue Scaffolds; D014945:Wound Healing; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; C495631:N-(2-carboxyethyl)chitosan; D011142:Polyvinyl Alcohol; D005349:Fibroins; D048271:Chitosan