title: [Research progress on intracellular metabolites based on metabolomics].
abstract: Being an essential component of systematic biology, metabolomics has received attention in recent years. It is a post genomic technology aimed at qualitative and quantitative analysis of all low molecular-mass metabolites present in complex biological samples, and mainly investigates the change of endogenous metabolites of a stimulated or disturbed biological system. Investigations into intracellular endogenous metabolites in metabolomics have great advancement in recent years. This review outlines the progress of metabolomics in cell culture analysis including sample preprocessing methods and metabolite target analysis, metabolic profiling analysis, metabolomics analysis and metabolic footprinting analysis.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110611, China.
authors.forename: Chen-chen
authors.initials: CC
authors.lastname: Zhang
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Sun
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D005591:Chemical Fractionation / Q000379:methods; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D055442:Metabolome; D055432:Metabolomics / Q000379:methods*