title: Synthesis and biological activity of nitric oxide-releasing derivatives of ferulic acid as potential agents for the treatment of chronic kidney diseases.
abstract: In order to search for novel potential agents for the treatment of chronic kidney diseases (CKD), nitric oxide (NO)-releasing derivatives (5a-c) of ferulic acid were synthesized and characterized by MS, 1H NMR, and elementary analysis. They showed different NO-releasing rate in the absence or presence of L-cysteine in vitro. In the adenine induced CKD rats, these compounds revealed reno-protective effect via lowering blood urea nitrogen (BUN), creatinine (Cr) in serum and malondialdehyde (MDA) in kidney, increasing NO and superoxide dismutase (SOD) level in kidney. Among them, 3-methoxy-4-(nitrooxy)ethoxy cinnamic acid (5a) was confirmed to have a higher NO-releasing rate in vitro and better effect in ameliorating adenine-induced kidney damage in rats.
authors.affiliation: Department of Pharmacy, College of Chemical and Chemistry Engineering, Hunan University, Changsha 410082, PR China. horrynew@126.com
authors.forename: Hao-Ran
authors.initials: HR
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Yan-Lai
authors.initials: YL
authors.lastname: Li
authors.forename: Min-You
authors.initials: MY
authors.lastname: Qi
authors.forename: Wu-Kun
authors.initials: WK
authors.lastname: Liu
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003373:Coumaric Acids / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D051436:Renal Insufficiency, Chronic / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D003373:Coumaric Acids; D009569:Nitric Oxide; C004999:ferulic acid