title: Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures.
abstract: OBJECTIVE
  To explore the relationship between nesfatin-1 and growth and development in newborns.
  
  
  METHODS
  Blood samples for nesfatin-1, ghrelin, insulinlike growth factor-1 (IGF-1), insulin and glucose were obtained from preterm (n = 53) and term infants (n = 60), including appropriate for gestational age (AGA) (n = 32) and small for gestational age (SGA) infants (n = 28). The relationship between nesfatin-1 and other metabolic hormones or anthropometric parameters was evaluated.
  
  
  RESULTS
  The concentrations of nesfatin-1, ghrelin and insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) were higher in SGA than AGA infants (p = 0.0358, 0.0163, 0.0001 and 0.0051, respectively), but IGF-1 levels and homeostasis model assessment-insulin sensitivity index (HOMA-ISI) were lower (p = 0.033 and 0.0001, respectively). Nesfatin-1 levels in SGA infants were higher on postnatal day 0 (PNDO) than in AGA infants (p = 0.0358) and lower on PND7 (p = 0.0002) and PND28 (p = 0.0488). A negative correlation showed between nesfatin-1 and oral calorie intake (r = -0.446; p = 0.017) and HOMA-ISI (r = -0.398; p = 0.036), and a positive correlation between nesfatin-1 and HOMA-IR (r = 0.43; p = 0.023) in SGA infants.
  
  
  CONCLUSIONS
  Nesfatin-1 is involved in the physiological regulation of intrauterine and postnatal growth and development in SGA infants.
authors.affiliation: Hebei Medical University, Shijiazhuang, Hebei, 050017, China.
authors.forename: Ya-Ying
authors.initials: YY
authors.lastname: Cheng
authors.forename: Xiu-Mian
authors.initials: XM
authors.lastname: Zhao
authors.forename: Bao-Ping
authors.initials: BP
authors.lastname: Cai
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Ma
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Yin
authors.forename: Guang-Yao
authors.initials: GY
authors.lastname: Song
mesh_terms: D000886:Anthropometry; D001837:Body Weights and Measures; D002135:Calcium-Binding Proteins / Q000097:blood* / Q000378:metabolism / Q000502:physiology; D002657:Child Development / Q000502:physiology; D015331:Cohort Studies; D004268:DNA-Binding Proteins / Q000097:blood* / Q000378:metabolism / Q000502:physiology; D004703:Endocrine System / Q000378:metabolism / Q000502:physiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn / Q000097:blood* / Q000254:growth & development / Q000378:metabolism; D007234:Infant, Premature / Q000097:blood / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D007236:Infant, Small for Gestational Age / Q000097:blood / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D008297:Male; D008660:Metabolism / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000097:blood* / Q000378:metabolism / Q000502:physiology; D000080866:Nucleobindins; D047929:Term Birth / Q000097:blood / Q000378:metabolism / Q000502:physiology
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins