title: Prominin-1 (CD133) Expression in the Prostate and Prostate Cancer: A Marker for Quiescent Stem Cells.
abstract: The origin and phenotype of stem cells in human prostate cancer remains a subject of much conjecture. In this scenario, CD133 has been successfully used as a stem cell marker in both normal prostate and prostate cancer. However, cancer stem cells have been identified without the use of this marker, opening up the possibility of a CD133 negative cancer stem cell. In this chapter, we review the current literature regarding prostate cancer stem cells, with specific reference to the expression of CD133 as a stem cell marker to identify and purify stem cells in normal prostate epithelium and prostate cancer.
authors.affiliation: YCR Cancer Research Unit, Department of Biology, University of York, Wentworth Way, YO10 5DD, York, UK.
authors.forename: Davide
authors.initials: D
authors.lastname: Pellacani
authors.forename: Emma E
authors.initials: EE
authors.lastname: Oldridge
authors.forename: Anne T
authors.initials: AT
authors.lastname: Collins
authors.forename: Norman J
authors.initials: NJ
authors.lastname: Maitland
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D008297:Male; D014411:Neoplastic Stem Cells / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism
chemical_list: D015415:Biomarkers