title: Chronic pancreatitis in dogs.
abstract: Chronic pancreatitis used to be considered uncommon in dogs, but recent pathological and clinical studies have confirmed that it is in fact a common and clinically significant disease. Clinical signs can vary from low-grade recurrent gastrointestinal signs to acute exacerbations that are indistinguishable from classical acute pancreatitis. Chronic pancreatitis is a significant cause of chronic pain in dogs, which must not be underestimated. It also results in progressive impairment of endocrine and exocrine function and the eventual development of diabetes mellitus or exocrine pancreatic insufficiency or both in some affected dogs at end stage. The etiology is unknown in most cases. Chronic pancreatitis shows an increased prevalence in certain breeds, and recent work in English Cocker Spaniels suggests it is part of a polysystemic immune-mediated disease in this breed. The histological and clinical appearance is different in different breeds, suggesting that etiologies may also be different. Diagnosis is challenging because the sensitivities of the available noninvasive tests are relatively low. However, with an increased index of suspicion, clinicians will recognize more cases that will allow them to institute supportive treatment to improve the quality of life of the patient.
authors.affiliation: Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom. pjw36@cam.ac.uk
authors.forename: Penny
authors.initials: P
authors.lastname: Watson
mesh_terms: D000818:Animals; D001947:Breeding; D004283:Dog Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D050500:Pancreatitis, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy / Q000662:veterinary*; D010375:Pedigree; D015995:Prevalence; D012307:Risk Factors