title: Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study.
abstract: OBJECTIVE
  Age at adiposity rebound (AR) is associated with obesity and Type 2 Diabetes in adults. The aim of the present study was to investigate the role of age at AR in adult fat mass, fat distribution and pubertal timing for a Swedish cohort.
  
  
  METHODS
  This is a retrospective cohort study. Detailed growth charts were retrieved for the men participating in the population-based GOOD (Gothenburg Osteoporosis and Obesity Determinants) study (n=573). Body composition was analysed using dual X-ray absorptiometry and computed tomography at 18-20 years of age. Age and BMI at AR were calculated using pediatric growth charts and AR was defined as the lowest BMI between 3 and 9 years of age.
  
  
  RESULTS
  Subjects were divided into early (age at AR below 5.4 years of age), middle (age at AR 5.4 to 6.8 years of age) and late (age at AR after 6.8 years of age) age at AR tertiles. Subjects in the early age at AR tertile had higher young adult BMI (+8%), whole body fat mass (+34%) and amount of subcutaneous adipose tissue (+61%) than the subjects in the middle and late tertiles (p<0.01). The early age at AR tertile had an increased risk of obesity (Odds Ratio 4.1 [95% CI 1.2-13.9]) compared with the middle and late tertiles. In addition, the early age at AR tertile had Peak Height Velocity (PHV) 7 months earlier than the late tertile.
  
  
  CONCLUSIONS
  Early age at AR was associated with young adult obesity as a consequence of a high amount of subcutaneous adipose tissue in men. In addition we made the novel observation that early age at AR was associated with an early puberty in men.
authors.affiliation: Center for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.
authors.forename: Claes
authors.initials: C
authors.lastname: Ohlsson
authors.forename: Mattias
authors.initials: M
authors.lastname: Lorentzon
authors.forename: Ensio
authors.initials: E
authors.lastname: Norjavaara
authors.forename: Jenny M
authors.initials: JM
authors.lastname: Kindblom
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000503:physiopathology*; D000367:Age Factors; D000886:Anthropometry; D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D057238:Growth Charts; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D016017:Odds Ratio; D011627:Puberty / Q000502:physiology; D012189:Retrospective Studies; D013548:Sweden / Q000453:epidemiology; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D020738:Leptin