title: Validation of EuroSCORE II on a single-centre 3800 patient cohort.
abstract: OBJECTIVE
  To compare and validate the new European System for Cardiac Operative Risk Evaluation (EuroSCORE) II with EuroSCORE at our institution.
  
  
  METHODS
  The logistic EuroSCORE and EuroSCORE II were calculated on the entire patient cohort undergoing major cardiac surgery at our centre between January 2005 and December 2010. The goodness of fit was compared by means of the Hosmer-Lemeshow (HL) chi-squared test and the area under the curve (AUC) of the receiver operating characteristic curves of both scales applied to the same sample of patients. These analyses were repeated and stratified by the type of surgery.
  
  
  RESULTS
  Mortality of 5.66% was observed, with estimated mortalities according to logistic EuroSCORE and EuroSCORE II of 9 and 4.46%, respectively. The AUC for EuroSCORE (0.82, 95% confidence interval [CI] 0.79-0.85) was lower than that for EuroSCORE II (0.85, 95% CI 0.83-0.87) without the differences being statistically significant (P = 0.056). Both scales showed a good discriminative capacity for all the pathologies subgroups. The two scales showed poor calibration in the sample: EuroSCORE (χ(2) = 39.3, P(HL) < 0.001) and EuroSCORE II (χ(2) = 86.69, P(HL) < 0.001). The calibration of EuroSCORE was poor in the groups of patients undergoing coronary (P(HL) = 0.01), valve (P(HL) = 0.01) and combined coronary valve surgery (P(HL) = 0.012); and that of EuroSCORE II in the group of coronary (P(HL) = 0.001) and valve surgery (P(HL) < 0.001) patients.
  
  
  CONCLUSIONS
  EuroSCORE II demonstrated good discriminative capacity and poor calibration in the patients undergoing major cardiac surgery at our centre.
authors.affiliation: Department of Cardiac Surgery, Hospital Clínico San Carlos, Madrid, Spain. manuelcarneroalcazar@hotmail.es
authors.forename: Manuel
authors.initials: M
authors.lastname: Carnero-Alcázar
authors.forename: Jacobo Alberto
authors.initials: JA
authors.lastname: Silva Guisasola
authors.forename: Fernando José
authors.initials: FJ
authors.lastname: Reguillo Lacruz
authors.forename: Luis Carlos
authors.initials: LC
authors.lastname: Maroto Castellanos
authors.forename: Javier
authors.initials: J
authors.lastname: Cobiella Carnicer
authors.forename: Enrique
authors.initials: E
authors.lastname: Villagrán Medinilla
authors.forename: Teresa
authors.initials: T
authors.lastname: Tejerina Sánchez
authors.forename: José Enrique
authors.initials: JE
authors.lastname: Rodríguez Hernández
mesh_terms: D000368:Aged; D019540:Area Under Curve; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000401:mortality*; D016009:Chi-Square Distribution; D003661:Decision Support Techniques; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013030:Spain; D016896:Treatment Outcome