title: The effect of polymerized placenta hemoglobin on renal ischemia/reperfusion injury.
abstract: The goal of this study was to investigate whether hemoglobin-based oxygen carrier (HBOC) attenuated ischemia/reperfusion (I/R)-induced kidney injury. Male SD rats were randomly divided into a sham group, I/R group, and HBOC group (injection of 0.1 gHb/kg PolyPHb). The ischemia was induced by bilateral renal pedicle cross-clamping for 45min. Then the clamp was released to allow 24h reperfusion. Without increasing blood pressure, PolyPHb reduced the blood urea nitrogen and creatinine in plasma and attenuated the tumor necrosis factor-α and interleukin-8 in kidney tissue. Therefore, our findings suggest that PolyPHb could reduce kidney injury after I/R injury, and this effect was probably associated with the depressed inflammatory response.
authors.affiliation: Laboratory of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Daqin
authors.initials: D
authors.lastname: Liao
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Chen
authors.forename: Chengmin
authors.initials: C
authors.lastname: Yang
authors.forename: Xuewen
authors.initials: X
authors.lastname: Xu
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage*; D005260:Female; D006454:Hemoglobins / Q000008:administration & dosage*; D006801:Humans; D016209:Interleukin-8 / Q000276:immunology; D007668:Kidney / Q000098:blood supply*; D008297:Male; D023421:Models, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000097:blood / Q000276:immunology / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha