title: Estimation of superoxide dismutase and glutathione peroxidase in oral submucous fibrosis, oral leukoplakia and oral cancer--a comparative study.
abstract: Present study was undertaken to estimate and compare erythrocyte superoxide dismutase (E-SOD) and Glutathione peroxidase (GPx) levels in oral submucous fibrosis, oral leukoplakia and oral cancer patients and age/sex matched healthy subjects, 25 in each group. Statistically significant (P<0.001) decrease in E-SOD and GPx levels were observed in OSF, oral leukoplakia and oral cancer groups as compared to the control group. Oral leukoplakia group showed lower levels in comparison with OSF (P>0.05). Oral cancer group had the lowest levels amongst the study groups. Imbalance in antioxidant enzyme status may be considered as one of the factors responsible for the pathogenesis of cancer and may serve as a potential biomarker and therapeutic target to reduce the malignant transformation in oral premalignant lesions/conditions.
authors.affiliation: Oral Medicine and Radiology, The Oxford Dental College Hospital and Research Centre. shubha.gurudath@gmail.com
authors.forename: Shubha
authors.initials: S
authors.lastname: Gurudath
authors.forename: Ks
authors.initials: K
authors.lastname: Ganapathy
authors.forename: Sujatha
authors.initials: S
authors.lastname: D
authors.forename: Anuradha
authors.initials: A
authors.lastname: Pai
authors.forename: Sushmini
authors.initials: S
authors.lastname: Ballal
authors.forename: Asha
authors.initials: A
authors.lastname: Ml
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007972:Leukoplakia, Oral / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology*; D009914:Oral Submucous Fibrosis / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000097:blood*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase