title: The role of Allium cepa on aluminum-induced reproductive dysfunction in experimental male rat models.
abstract: OBJECTIVE
  Reproductive toxicity is a major challenge associated with aluminum (Al) exposure. Studies that associated Al with reproductive dysfunction did not account for the possible influence of Allium cepa extract. This study, therefore, investigates the influence of A. cepa on aluminum-induced reproductive dysfunction.
  
  
  METHODS
  SIX MALE RATS PER GROUP WERE ASSIGNED TO ONE OF THE FOLLOWING FOUR TREATMENT GROUPS: The control animals were on control diet. A. cepa-treated rats received 1 ml of the extract/100 g body weight (BW), Al-treated rats received 100 mg AlCl(3) /kg BW, and A.cepa+Al received 1 ml of the extract/100 g BW plus 100 mg AlCl(3) /kg BW. Rats were orally administered their respective doses. A. cepa treatment was for 8 weeks, while Al treatment was for the last 3 days of the experimental period.
  
  
  RESULTS
  Results obtained showed that Al significantly decreased (P < 0.05) plasma testosterone, follicular stimulating hormone (FSH), luteinizing hormone (LH), sperm count, motility, morphology and viability, superoxide dismutase (SOD) and catalase (CAT) activities, while lipid peroxidation index [malondialdehyde (MDA)] was significantly (P < 0.05) increased. Reproductive hormones (except testosterone), sperm qualities, and enzymatic antioxidants were significantly (P < 0.05) increased in A. cepa-treated rats and A. cepa plus Al-treated rats, while MDA was significantly (P < 0.05) improved. Weights of testes were comparable in all groups.
  
  
  CONCLUSIONS
  It is thus suggested that Al exerts reproductive dysfunction by oxidative damage. A. cepa antagonizes the toxic effects of AlCl(3) and improves the antioxidant status and sperm quality of male rat. However, testosterone level did not increase with A. cepa treatment.
authors.affiliation: Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
authors.forename: Serah F
authors.initials: SF
authors.lastname: Ige
authors.forename: Roland E
authors.initials: RE
authors.lastname: Akhigbe