title: [Preservatives from the perspective of glaucoma surgery].
abstract: Trabeculectomy is still the gold standard in the surgical treatment of glaucoma patients. Development of a bleb is the primary goal of this procedure and the conjunctival status is therefore decisive. Only a good functioning bleb renders good intraocular pressure (IOP) control. Scar tissue formation leads to bleb failure which is quite common despite the use of antiproliferative agents, such as mitomycin C and 5 fluoruracil. Wound healing is important and is influenced and impaired by the chronic use of topical antiglaucoma drugs. Therefore, complete abstinence is recommended from 4-6 weeks prior to a planned trabeculectomy; however, it seems mandatory to completely abolish preservatives such as drops containing benzalkonium chloride to enhance trabeculectomy success rates.
authors.affiliation: Universitätsaugenklinik, Otto von Guericke Universität, Leipziger Str. 44, 39120, Magdeburg, Deutschland. hagen.thieme@med.ovgu.de
authors.forename: H
authors.initials: H
authors.lastname: Thieme
authors.forename: K K
authors.initials: KK
authors.lastname: van der Velden
mesh_terms: D001548:Benzalkonium Compounds / Q000009:adverse effects*; D002921:Cicatrix / Q000209:etiology* / Q000517:prevention & control*; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D014130:Trabeculectomy / Q000009:adverse effects* / Q000379:methods*
chemical_list: D001548:Benzalkonium Compounds; D011310:Preservatives, Pharmaceutical