title: Traditional Chinese herbal medicine as a source of molecules with antiviral activity.
abstract: Traditional Chinese herbal medicine (TCHM) is widely used in the prevention and treatment of viral infectious diseases. However, the operative mechanisms of TCHM remain largely obscure, mainly because of its complicated nature and the fragmented nature of research. In recent years, systematic methodologies have been developed to discover the active compounds in TCHM and to elucidate its underlying mechanisms. In this review, we summarize recent progress in TCHM-based antiviral research in China and other Asian countries. In particular, this review focuses on progress in targeting key steps in the viral replication cycle and key cellular components of the host defense system. Recent developments in centralized and standardized TCHM screening and databases are also summarized.
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification*; D001208:Asia; D035843:Biomedical Research / Q000639:trends; D029001:Herbal Medicine; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*; D014777:Virus Diseases / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents