title: [Incidence of human herpes virus 1-4 type in saliva of 245 human immunodeficiency virus-infected patients].
abstract: OBJECTIVE
  To determine the incidence of human herpes virus (HHV) 1-4 type including herpes simplex virus type-1 (HSV-1), herpes simplex virus type-2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus(EBV) in the saliva of human immunodeficiency virus (HIV) -infected patients.
  
  
  METHODS
  The incidence of salivary HSV-1, HSV-2, VZV and EBV from 245 HIV-seropositive individuals and control group was used to investigate by polymerase chain reaction(PCR) or nested PCR. The data was analyzed by SPSS 18.0 statistical software.
  
  
  RESULTS
  In the 245 HIV-seropositive individuals, the detection rates of HSV-1, HSV-2, VZV, EBV were 29.0%, 3.3%, 4.1%, 82.0%. In the control group, the detection rates of HSV-1, HSV-2, VZV, EBV were 13.3%, 0, 0, 36.7%. Four HHVs were significantly more prevalent in the salivas of HIV-seropositive persons than those in the control group (P < 0.01). The detection rates of HSV-1, HSV-2, VZV and EBV DNA were no difference between the HIV-positive group with highly active antiretroviral therapy (HAART) and HIV-positive group without HAART (P > 0.05).
  
  
  CONCLUSIONS
  There is a high prevalence of HHV infection in HIV-infected people in Yunnan. The most common virus are EBV, followed by HSV-1, but VZV and HSV-2 are rarely detected. HHV co-infection is also observed.
authors.affiliation: Dept. of Stomatology, Kunming Medical University Yan'an Hospital, Kunming Yan'an Hospital, Kunming 650051, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wu
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhai
authors.forename: Liuying'
authors.initials: L
authors.lastname: Ge
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Qi
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.forename: Kaiwen
authors.initials: K
authors.lastname: Duan
mesh_terms: D000328:Adult; D002681:China; D004279:DNA, Viral; D015658:HIV Infections; D014645:Herpesvirus 3, Human; D006801:Humans; D015994:Incidence; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012463:Saliva
chemical_list: D004279:DNA, Viral