title: Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor.
abstract: We describe a novel 7-aminopyrazolo[1,5-a]pyrimidine (7-APP) derivative as a potent hepatitis C virus (HCV) inhibitor. A series of 7-APPs was synthesized and evaluated for inhibitory activity against HCV in different cell culture systems. The synthesis and preliminary structure-activity relationship study of 7-APP are reported.
authors.affiliation: Medicinal Chemistry 2, Institut Pasteur Korea, Sampyeong-dong 696, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Republic of Korea.
authors.forename: Jong Yeon
authors.initials: JY
authors.lastname: Hwang
authors.forename: Marc Peter
authors.initials: MP
authors.lastname: Windisch
authors.forename: Suyeon
authors.initials: S
authors.lastname: Jo
authors.forename: Keumhyun
authors.initials: K
authors.lastname: Kim
authors.forename: Sunju
authors.initials: S
authors.lastname: Kong
authors.forename: Hyoung Cheul
authors.initials: HC
authors.lastname: Kim
authors.forename: Soohyun
authors.initials: S
authors.lastname: Kim
authors.forename: Heeyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Myung Eun
authors.initials: ME
authors.lastname: Lee
authors.forename: Youngmi
authors.initials: Y
authors.lastname: Kim
authors.forename: Jihyun
authors.initials: J
authors.lastname: Choi
authors.forename: Dong-Sik
authors.initials: DS
authors.lastname: Park
authors.forename: Eunjung
authors.initials: E
authors.lastname: Park
authors.forename: Jeongjin
authors.initials: J
authors.lastname: Kwon
authors.forename: Jiyoun
authors.initials: J
authors.lastname: Nam
authors.forename: Sujin
authors.initials: S
authors.lastname: Ahn
authors.forename: Jonathan
authors.initials: J
authors.lastname: Cechetto
authors.forename: Junwon
authors.initials: J
authors.lastname: Kim
authors.forename: Michel
authors.initials: M
authors.lastname: Liuzzi
authors.forename: Zaesung
authors.initials: Z
authors.lastname: No
authors.forename: Jinhwa
authors.initials: J
authors.lastname: Lee
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: C580963:7-aminopyrazolo(1,5-a)pyrimidine; D000998:Antiviral Agents; D011720:Pyrazoles; D011743:Pyrimidines