title: LncRNADisease: a database for long-non-coding RNA-associated diseases.
abstract: In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease. In recent years, a large number of lncRNAs have been identified and increasing evidence shows that lncRNAs play critical roles in various biological processes. Therefore, the dysfunctions of lncRNAs are associated with a wide range of diseases. It thus becomes important to understand lncRNAs' roles in diseases and to identify candidate lncRNAs for disease diagnosis, treatment and prognosis. For this purpose, a high-quality lncRNA-disease association database would be extremely beneficial. Here, we describe the LncRNADisease database that collected and curated approximately 480 entries of experimentally supported lncRNA-disease associations, including 166 diseases. LncRNADisease also curated 478 entries of lncRNA interacting partners at various molecular levels, including protein, RNA, miRNA and DNA. Moreover, we annotated lncRNA-disease associations with genomic information, sequences, references and species. We normalized the disease name and the type of lncRNA dysfunction and provided a detailed description for each entry. Finally, we developed a bioinformatic method to predict novel lncRNA-disease associations and integrated the method and the predicted associated diseases of 1564 human lncRNAs into the database.
authors.affiliation: Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, China.
authors.forename: Geng
authors.initials: G
authors.lastname: Chen
authors.forename: Ziyun
authors.initials: Z
authors.lastname: Wang
authors.forename: Dongqing
authors.initials: D
authors.lastname: Wang
authors.forename: Chengxiang
authors.initials: C
authors.lastname: Qiu
authors.forename: Mingxi
authors.initials: M
authors.lastname: Liu
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
authors.forename: Qipeng
authors.initials: Q
authors.lastname: Zhang
authors.forename: Guiying
authors.initials: G
authors.lastname: Yan
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Cui
mesh_terms: D019295:Computational Biology / Q000379:methods; D030561:Databases, Nucleic Acid; D004194:Disease / Q000235:genetics*; D006801:Humans; D020407:Internet; D058977:Molecular Sequence Annotation; D062085:RNA, Long Noncoding / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D062085:RNA, Long Noncoding