title: Mycophenolic Acid pharmacokinetics early after kidney transplant.
abstract: OBJECTIVE
  To determine the mycophenolic acid pharmacokinetic profile early after transplant in Iranian kidney graft recipients.
  
  
  METHODS
  A cross-sectional study was performed during 6 months in 31 patients who recently had kidney transplant and received fixed doses of mycophenolate mofetil (2 g/d). The plasma levels of mycophenolic acid were determined by high performance liquid chromatography.
  
  
  RESULTS
  The mean first mycophenolic acid peak level was 10 ± 5 mg/L. The mean mycophenolic acid area under the curve was 26 ± 19 mgh/L and apparent clearance was 57 ± 55 L/h. The mycophenolic acid area under the curve values of only 8 patients (26%) were within the therapeutic range (30-60 mgh/L). The first, second, and third mycophenolic acid peak levels correlated significantly with mycophenolic acid area under the curve (P < .05). Mycophenolic acid concentration at 10 hours had the highest correlation with mycophenolic acid area under the curve (r=0.962; P < .05). No statistically significant differences were evident in the mean mycophenolic acid area under the curve between men and women.
  
  
  CONCLUSIONS
  There was a high degree of variation between different patients in mycophenolic acid pharmacokinetics early after kidney transplant.
authors.affiliation: Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Nazanin
authors.initials: N
authors.lastname: Honarbakhsh
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Rouini
authors.forename: Mahboob
authors.initials: M
authors.lastname: Lesan-Pezeshki
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Javadi
authors.forename: Iman
authors.initials: I
authors.lastname: Karimzadeh
authors.forename: Niayesh
authors.initials: N
authors.lastname: Mohebbi
authors.forename: Kheirollah
authors.initials: K
authors.lastname: Gholami
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003430:Cross-Sectional Studies; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics*; D007492:Iran; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid