title: Prodromes, precipitants, and risk factors for relapse in bipolar disorder.
abstract: OBJECTIVE
  The purpose of this qualitative review is to examine prodromes, precipitants, and risk factors for repeated episodes of mania and depression in bipolar disorder.
  
  
  METHODS
  PubMed, EMBASE, and PsychInfo were searched for "bipolar disorder" in conjunction with: "prodromes", "triggers", and "life change events".
  
  
  RESULTS
  Phenomenology and prevalence of prodromes, precipitants, and risk factors are described, and their therapeutic implications are outlined.
  
  
  CONCLUSIONS
  Most patients with bipolar disorder are able to recognize their prodromes. This ability depends largely on insight. Psychoeducation focused on improving various aspects of insight, including treatment adherence, reduces incidence of relapses in bipolar disorder.
authors.affiliation: Department of Psychiatry, University Hospital Olomouc, Czech Republic. klaralat@centrum.cz
authors.forename: Klara
authors.initials: K
authors.lastname: Latalova
authors.forename: Jan
authors.initials: J
authors.lastname: Prasko
authors.forename: Tomas
authors.initials: T
authors.lastname: Diveky
authors.forename: Dana
authors.initials: D
authors.lastname: Kamaradova
authors.forename: Ales
authors.initials: A
authors.lastname: Grambal
authors.forename: Hana
authors.initials: H
authors.lastname: Velartova
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D062706:Prodromal Symptoms; D012307:Risk Factors; D055502:Secondary Prevention
chemical_list: D000928:Antidepressive Agents