title: Structure and Mechanisms of SF1 DNA Helicases.
abstract: Superfamily I is a large and diverse group of monomeric and dimeric helicases defined by a set of conserved sequence motifs. Members of this class are involved in essential processes in both DNA and RNA metabolism in all organisms. In addition to conserved amino acid sequences, they also share a common structure containing two RecA-like motifs involved in ATP binding and hydrolysis and nucleic acid binding and unwinding. Unwinding is facilitated by a "pin" structure which serves to split the incoming duplex. This activity has been measured using both ensemble and single-molecule conditions. SF1 helicase activity is modulated through interactions with other proteins.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA, raneykevind@uams.edu.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Raney
authors.forename: Alicia K
authors.initials: AK
authors.lastname: Byrd
authors.forename: Suja
authors.initials: S
authors.lastname: Aarattuthodiyil
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry; D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D017124:Conserved Sequence; D004265:DNA Helicases / Q000737:chemistry
chemical_list: D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D004265:DNA Helicases