title: Carbapenem-sparing antibiotic regimens for infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae in intensive care unit.
abstract: A carbapenem-sparing regimen of tigecycline plus gentamicin or colistin was effective for treating 24 of 26 (92%) Klebsiella pneumoniae carbapenemase-producing K. pneumoniae infectious episodes in 22 polytrauma intensive care unit patients without comorbidities. The 30-day crude mortality rate was 14%. Regimens were considered appropriate in 12% of episodes according to the Vitek 2 System and in 100% based on E-test.
authors.affiliation: Fondazione Toscana Gabriele Monasterio, Azienda Ospedaliera Universitaria Pisana, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Sbrana
authors.forename: Paolo
authors.initials: P
authors.lastname: Malacarne
authors.forename: Bruno
authors.initials: B
authors.lastname: Viaggi
authors.forename: Sergio
authors.initials: S
authors.lastname: Costanzo
authors.forename: Piero
authors.initials: P
authors.lastname: Leonetti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Leonildi
authors.forename: Beatrice
authors.initials: B
authors.lastname: Casini
authors.forename: Carlo
authors.initials: C
authors.lastname: Tascini
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichetti
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000378:metabolism*; D015780:Carbapenems / Q000627:therapeutic use; D003091:Colistin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D007362:Intensive Care Units; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012189:Retrospective Studies; D000078304:Tigecycline; D016896:Treatment Outcome; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D005839:Gentamicins; D000078304:Tigecycline; D001618:beta-Lactamases; C063912:carbapenemase; D008911:Minocycline; D003091:Colistin