title: [Expression of peroxiredoxin 6 in gastric cancer and its clinical significance].
abstract: OBJECTIVE
  To elucidate the significance of anti-oxidant protein peroxiredoxin 6 (Prx6) expression in gastric cancer (GC) tissue.
  
  
  METHODS
  Eighty-six GC tissues and 69 para-cancer tissues from surgically resected specimens were included. And the clinico-pathological data were collected by reviewing medical records. Tissue microarray and immunohistochemistry (IHC) were used to detect Prx6 protein expression in tissues.
  
  
  RESULTS
  Prx6 protein was predominantly expressed in cytoplasm. Its expression rate in GC tissues (32.6%, n = 28) was significantly lower than that in para-cancer normal tissues (94.2%, n = 65, P < 0.05). And its protein overexpression rate in well and moderately-differentiated GC tissues was significantly higher than that in lowly-differentiated ones (39.6% (21/53) vs 6.1% (2/33), P < 0.05). Prx6 expression in gastric cancer tissues was not significantly related to age and sex of patients, lesion site, depth of invasion, clinical staging, vascular invasion and liver metastasis.
  
  
  CONCLUSIONS
  The level of Prx6 protein is lower in GC tissues than that in normal para-cancer ones. And it is significantly correlated with the differentiation degree of GC.
authors.affiliation: Department of Gastroenterology, Aerospace Clinical Medical School, Beijing, China.
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Guo
authors.forename: You-yong
authors.initials: YY
authors.lastname: Lü
authors.forename: Ya-li
authors.initials: YL
authors.lastname: Zhu
authors.forename: Gui-bin
authors.initials: GB
authors.lastname: Yang
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D054465:Peroxiredoxin VI / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: C515977:PRDX6 protein, human; D054465:Peroxiredoxin VI