title: Palladium-catalyzed direct ortho-acylation through an oxidative coupling of acetanilides with toluene derivatives.
abstract: A facile ortho-acylation of acetanilides by a Pd-catalyzed oxidative C-H activation was developed in which low toxic, stable, and commercially available toluene derivatives were first used as acylation reagents by a tandem reaction to form o-acylacetanilides with moderate to good yields. Inexpensive, safe, and environmentally benign TBHP was proved to be an effective oxidant for these transformations.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China.
authors.forename: Zhangwei
authors.initials: Z
authors.lastname: Yin
authors.forename: Peipei
authors.initials: P
authors.lastname: Sun
mesh_terms: D000083:Acetanilides / Q000737:chemistry*; D000215:Acylation; D002384:Catalysis; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D014050:Toluene / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: D000083:Acetanilides; D014050:Toluene; D010165:Palladium