title: Clinical screening of oropharyngeal dysphagia in patients with ALS.
abstract: OBJECTIVE
  It is a major issue to diagnose and detect oropharyngeal dysphagia in the early stage of ALS in order to avoid pulmonary and nutritional complications. The aim of this study was to validate a simple clinical test, the Volume-Viscosity Swallow Test (V-VST), to detect oropharyngeal dysphagia in this population.
  
  
  METHODS
  Twenty patients were included in this study (mean age: 66.1 ± 8.13, six women). All patients had their swallowing function assessed by videofluoroscopy and V-VST.
  
  
  RESULTS
  Among these 20 patients, 15 presented oropharyngeal dysphagia, diagnosed by videofluoroscopy, and five had normal swallowing. Norris score was lower in patients with oropharyngeal dysphagia compared to the patients with normal swallowing (27 ± 6 versus 36 ± 2; P=0.003). Among the 15 patients with oropharyngeal dysphagia, 14 had abnormal V-VST, and only one had normal V-VST. The sensibility of V-VST to detect oropharyngeal dysphagia in these patients with ALS was of 93%, and the specificity was of 80% (P=0.007). There was no significant difference between the two populations for ALSFRS score (22 ± 6 versus 20 ± 6) and body mass index (BMI) (26 ± 6 versus 26 ± 6 kg/m(2)).
  
  
  CONCLUSIONS
  The V-VST presented good sensibility and specificity. It may be interesting to use it systematically for the detection of oropharyngeal dysphagia in ALS, after confirming these results on a wider patient sample.
authors.affiliation: Service de physiologie, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Paris
authors.forename: O
authors.initials: O
authors.lastname: Martinaud
authors.forename: D
authors.initials: D
authors.lastname: Hannequin
authors.forename: A
authors.initials: A
authors.lastname: Petit
authors.forename: A
authors.initials: A
authors.lastname: Cuvelier
authors.forename: E
authors.initials: E
authors.lastname: Guedon
authors.forename: P
authors.initials: P
authors.lastname: Ropenneck
authors.forename: E
authors.initials: E
authors.lastname: Verin
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications*; D003680:Deglutition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009960:Oropharynx / Q000503:physiopathology*; D012680:Sensitivity and Specificity