title: Simple naphthalimide-based fluorescent sensor for highly sensitive and selective detection of Cd2+ and Cu2+ in aqueous solution and living cells.
abstract: A novel naphthalimide-based fluorescent sensor bearing the N,N'-bis(salicylidene)diethylenetriamine receptor was developed, which exhibited dual signaling behaviors for Cd(2+) and Cu(2+), and was applicable to the environmental and biological milieus. Upon addition of Cd(2+), the fluorescence intensity enhanced in a linear fashion with the maximum fluorescence intensity increase of about 4-fold. Moreover, with the sensor 1 and 1-Cd(2+) complex, Cu(2+) was easily recognized by marked fluorescence quenching. The selectivity and sensitivity of the sensor 1 for Cd(2+) were satisfactory and achieving a detection limit at the nanomolar level. The living cell image experiments demonstrated the value of sensor 1 in fluorescent visualization of Cd(2+) ions in biological systems.
authors.affiliation: Department of Chemistry, Jilin University, Changchun, 130021, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Qian
authors.initials: Q
authors.lastname: Wen
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Fei
authors.forename: Yaoxian
authors.initials: Y
authors.lastname: Li
authors.forename: Qingbiao
authors.initials: Q
authors.lastname: Yang
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Xu
mesh_terms: D002104:Cadmium / Q000032:analysis*; D045744:Cell Line, Tumor; D003300:Copper / Q000032:analysis*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions; D061986:MCF-7 Cells; D008856:Microscopy, Fluorescence; D053644:Naphthalimides / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D007477:Ions; D053644:Naphthalimides; D002104:Cadmium; D014867:Water; D003300:Copper