title: Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors.
abstract: Many pathogens hijack existing endocytic trafficking pathways to exert toxic effects in cells. Dynamin controls various steps of the intoxication process used by numerous pathogenic bacteria, viruses, and toxins. Targeting dynamin with pharmaceutical compounds may therefore have prophylactic potential. Here we review the growing number of pathogens requiring dynamin-dependent trafficking to intoxicate cells, outline the mode of internalization that leads to their pathogenicity, and highlight the protective effect of pharmacological and genetic approaches targeting dynamin function. We also assess the methodologies used to investigate the role of dynamin in the intoxication process and discuss the validity and potential pitfalls of using dynamin inhibitors (DIs) as therapeutics.
authors.affiliation: Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.
authors.forename: Callista B
authors.initials: CB
authors.lastname: Harper
authors.forename: Michel R
authors.initials: MR
authors.lastname: Popoff
authors.forename: Adam
authors.initials: A
authors.lastname: McCluskey
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Robinson
authors.forename: Frédéric A
authors.initials: FA
authors.lastname: Meunier
mesh_terms: D000178:Acrylamides / Q000494:pharmacology; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy*; D002177:Candidiasis / Q000188:drug therapy; D045744:Cell Line, Tumor; D022163:Clathrin-Coated Vesicles / Q000187:drug effects / Q000382:microbiology; D034281:Dynamins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D004705:Endocytosis / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D006835:Hydrazones / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009284:Naphthols / Q000494:pharmacology; D021381:Protein Transport / Q000187:drug effects; D022621:Shiga Toxin / Q000037:antagonists & inhibitors; D053586:Virus Internalization / Q000187:drug effects
chemical_list: C541935:2-cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)acrylamide; D000178:Acrylamides; D004791:Enzyme Inhibitors; D006835:Hydrazones; D007211:Indoles; D009284:Naphthols; C568360:dyngo-4a; D022621:Shiga Toxin; D034281:Dynamins