title: Association between TP53 Arg72Pro polymorphism and hepatocellular carcinoma risk: a meta-analysis.
abstract: BACKGROUND
  Previous studies on the association between the TP53 Arg72Pro polymorphism and hepatocellular carcinoma (HCC) risk obtained controversial findings. This study aimed to quantify the strength of the association by meta-analysis.
  
  
  METHODS
  We searched PubMed and Wangfang databases for published studies on the association between the TP53 Arg72Pro polymorphism and HCC risk, using the pooled odds ratio (OR) with its 95% confidence intervals (95% CI) for assessment.
  
  
  RESULTS
  10 studies with a total of 2,026 cases and 2,733 controls were finally included into this meta-analysis. Overall, the TP53 Arg72Pro polymorphism was not associated with HCC risk (all P values greaterth HCC risk in Caucasians in three genetic models (For Pro versus Arg, OR = 1.20, 95%CI 1.03-1.41; For ProPro versus ArgArg, OR = 1.74, 95%CI 1.23-2.47; For ProPro versus ArgPro/ArgArg, OR = 1.85, 95%CI 1.33-2.57). However, there was no significant association between the TP53 Arg72Pro polymorphism and HCC risk in East Asians (all P values greater than 0.10). No evidence of publication bias was observed.
  
  
  CONCLUSIONS
  Meta-analyses of available data suggest an obvious association between the TP53 Arg72Pro and HCC risk in Caucasians. However, the TP53 Arg72Pro polymorphism may have a race-specific effect on HCC risk and further studies are needed to elucidate this possible effect.
authors.affiliation: Department of Hepatobiliary, the 309th Hospital of Chinese People's Liberation Army, Haidian, Beijing, China.
authors.forename: Chang-Tao
authors.initials: CT
authors.lastname: Xu
authors.forename: Fang
authors.initials: F
authors.lastname: Zheng
authors.forename: Xin
authors.initials: X
authors.lastname: Dai
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Du
authors.forename: Hao-Run
authors.initials: HR
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Li
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016001:Confidence Intervals; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53