title: Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules.
abstract: Metal complexes with N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry and are now increasingly considered for the development of new chemical tools and metal based drugs. Ruthenium complexes of the type (p-cymene)(NHC)RuCl(2) interacted with biologically relevant thiols and selenols, which resulted in the inhibition of enzymes such as thioredoxin reductase or cathepsin B. Pronounced antiproliferative effects could be obtained provided that an appropriate cellular uptake was achieved. Inhibition of tumor cell growth was accompanied by a perturbation of metabolic parameters such as cellular respiration.
authors.affiliation: Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, D-38106 Braunschweig, Germany.
authors.forename: Luciano
authors.initials: L
authors.lastname: Oehninger
authors.forename: Maria
authors.initials: M
authors.lastname: Stefanopoulou
authors.forename: Hamed
authors.initials: H
authors.lastname: Alborzinia
authors.forename: Julia
authors.initials: J
authors.lastname: Schur
authors.forename: Stephanie
authors.initials: S
authors.lastname: Ludewig
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Namikawa
authors.forename: Alvaro
authors.initials: A
authors.lastname: Muñoz-Castro
authors.forename: Reinhard W
authors.initials: RW
authors.lastname: Köster
authors.forename: Knut
authors.initials: K
authors.lastname: Baumann
authors.forename: Stefan
authors.initials: S
authors.lastname: Wölfl
authors.forename: William S
authors.initials: WS
authors.lastname: Sheldrick
authors.forename: Ingo
authors.initials: I
authors.lastname: Ott
mesh_terms: D000818:Animals; D002401:Cathepsin B / Q000037:antagonists & inhibitors / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D004247:DNA / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000187:drug effects; D005980:Glutathione Reductase / Q000037:antagonists & inhibitors / Q000378:metabolism; D019073:HT29 Cells; D006801:Humans; D061986:MCF-7 Cells; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D018036:Selenium Compounds / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013880:Thioredoxin-Disulfide Reductase / Q000037:antagonists & inhibitors / Q000378:metabolism; D014357:Trypsin / Q000737:chemistry / Q000378:metabolism; D015027:Zebrafish / Q000254:growth & development
chemical_list: D056831:Coordination Complexes; D018036:Selenium Compounds; D013438:Sulfhydryl Compounds; C442270:selenol; C030011:carbene; D012428:Ruthenium; D004247:DNA; D005980:Glutathione Reductase; D013880:Thioredoxin-Disulfide Reductase; D014357:Trypsin; D002401:Cathepsin B; D008697:Methane