title: Impact of insulin resistance on 1-year clinical outcomes in non-diabetic patients undergoing percutaneous coronary intervention with drug-eluting stents.
abstract: BACKGROUND
  Insulin resistance (IR) is known to be a risk factor for coronary artery disease (CAD). We aimed to evaluate the impact of IR on 1-year clinical outcomes in non-diabetic CAD patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DESs).
  
  
  RESULTS
  A total of 229 consecutive non-diabetic CAD patients treated with DESs were enrolled. Study population was divided into IR group [homeostasis model assessment (HOMA) index ≥ 2.5, n=54] and non-IR group (HOMA index<2.5, n=175). Baseline clinical and procedural characteristics were similar between the groups except higher incidence of high-sensitivity C-reactive protein and lower incidence of multivessel disease as the target vessel in the non-IR group. There was a trend toward longer restenosis lesion length in the IR group at 6 months angiographic follow up but composite major clinical outcomes up to 1 year were similar between the two groups.
  
  
  CONCLUSIONS
  Despite worse trend in angiographic outcomes in the IR group (HOMA index ≥ 2.5), it was not translated into worse 1-year major clinical outcomes following PCI with DESs as compared to the non-IR group.
authors.affiliation: Department of Internal Medicine, Wonkwang University Sanbon Hospital, Gunpo, Republic of Korea.
authors.forename: In Kyeom
authors.initials: IK
authors.lastname: Hwang
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Kim
authors.forename: Seung-Woon
authors.initials: SW
authors.lastname: Rha
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Ra
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Seo
authors.forename: Ji Kyoung
authors.initials: JK
authors.lastname: Lee
authors.forename: Jin Oh
authors.initials: JO
authors.lastname: Na
authors.forename: Cheol Ung
authors.initials: CU
authors.lastname: Choi
authors.forename: Hong Euy
authors.initials: HE
authors.lastname: Lim
authors.forename: Seong Woo
authors.initials: SW
authors.lastname: Han
authors.forename: Eung Ju
authors.initials: EJ
authors.lastname: Kim
authors.forename: Chang Gyu
authors.initials: CG
authors.lastname: Park
authors.forename: Hong Seog
authors.initials: HS
authors.lastname: Seo
authors.forename: Dong Joo
authors.initials: DJ
authors.lastname: Oh
authors.forename: Sang Myung
authors.initials: SM
authors.lastname: Choi
authors.forename: Byoung Gy
authors.initials: BG
authors.lastname: Chae
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Seong Gyu
authors.initials: SG
authors.lastname: Yoon
authors.forename: Il Woo
authors.initials: IW
authors.lastname: Suh
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000401:mortality; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000401:mortality / Q000601:surgery*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology; D054855:Drug-Eluting Stents; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007328:Insulin