title: Aging gonads, glands, and gametes: immutable or partially reversible changes?
abstract: Decreased ovarian testosterone production, granulosa cell dysfunction, oocyte telomere shortening and mitochondrial defects, and sperm DNA fragmentation all contribute to reproductive aging. Maneuvers aimed at correcting these abnormalities, including reduction of oxidative stress, improved lifestyle and nutrition, and the role of supplements, are reviewed.
authors.affiliation: Reproductive Partners Medical Group, Redondo Beach, California. Electronic address: drmeldrum@gmail.com.
authors.forename: David R
authors.initials: DR
authors.lastname: Meldrum
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D053938:DNA Fragmentation; D019587:Dietary Supplements; D004702:Endocrine Glands / Q000502:physiology*; D005260:Female; D005854:Germ Cells / Q000502:physiology*; D006066:Gonads / Q000502:physiology*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D060728:Reproductive Health; D059506:Telomere Shortening / Q000502:physiology; D013739:Testosterone / Q000378:metabolism
chemical_list: D013739:Testosterone