title: Antibiotic-modified hydrogel coatings on titanium dental implants.
abstract: Implant-associated infections represent an occasional but serious problem in dental and/or orthopaedic surgery. A possible solution to prevent the initial bacterial adhesion may be the coating of the implant surface with a thin layer of antibiotic-loaded biocompatible polymer. Hydrogels are one of the promising and versatile materials as antibiotic controlled release systems. In this work, antibiotic-modified poly(ethylene-glycol diacrylate) hydrogel coatings on titanium substrates were prepared by electrochemical polymerization and tested against methicillin resistant Staphylococcus aureus (ATCC 33591). Two different methods to load vancomycin and ceftriaxone were used. We show that the proposed titanium coatings displayed an interesting antibacterial activity, however, further studies on their effective cytotoxicity will furnish evidence of their real clinical efficacy.
authors.affiliation: Department of Chemistry and Industrial Chemistry, University of Pisa, S. Piero a Grado, Pisa, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cometa
authors.forename: M
authors.initials: M
authors.lastname: Mattioli-Belmonte
authors.forename: D
authors.initials: D
authors.lastname: Cafagna
authors.forename: R
authors.initials: R
authors.lastname: Iatta
authors.forename: E
authors.initials: E
authors.lastname: Ceci
authors.forename: E
authors.initials: E
authors.lastname: De Giglio
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D015921:Dental Implants; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage*; D056951:Photoelectron Spectroscopy; D014025:Titanium
chemical_list: D000900:Anti-Bacterial Agents; D015921:Dental Implants; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D014025:Titanium