title: Targeting the right regulatory T-cell population for tumor immunotherapy.
abstract: Regulatory T cells (Tregs) that suppress tumor-specific T cell-mediated immune responses are the subject of an intense wave of investigation. We recently reported that a subset of Tregs, namely effector/memory CD25(low) cells, are responsible for suppressing high avidity tumor-specific T cells in mouse mammary tumors. Here, we discuss additional findings that clarify this mechanism of Treg-mediated immunosuppression.
authors.affiliation: The Sidney Kimmel Cancer Center; Johns Hopkins University School of Medicine; Baltimore, MD USA ; Department of Oncology; Johns Hopkins University School of Medicine; Baltimore, MD USA ; Graduate Program in Immunology; Johns Hopkins School of Medicine; Baltimore, MD USA.
authors.forename: Vivian L
authors.initials: VL
authors.lastname: Weiss
authors.forename: Timothy H
authors.initials: TH
authors.lastname: Lee
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Jaffee
authors.forename: Todd D
authors.initials: TD
authors.lastname: Armstrong