title: Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy.
abstract: Curved surfaces, complex geometries, and time-dynamic deformations of the heart create challenges in establishing intimate, nonconstraining interfaces between cardiac structures and medical devices or surgical tools, particularly over large areas. We constructed large area designs for diagnostic and therapeutic stretchable sensor and actuator webs that conformally wrap the epicardium, establishing robust contact without sutures, mechanical fixtures, tapes, or surgical adhesives. These multifunctional web devices exploit open, mesh layouts and mount on thin, bio-resorbable sheets of silk to facilitate handling in a way that yields, after dissolution, exceptionally low mechanical moduli and thicknesses. In vivo studies in rabbit and pig animal models demonstrate the effectiveness of these device webs for measuring and spatially mapping temperature, electrophysiological signals, strain, and physical contact in sheet and balloon-based systems that also have the potential to deliver energy to perform localized tissue ablation.
authors.affiliation: Center for Nanoparticle Research of Institute for Basic Science, World Class University Program of Chemical Convergence for Energy and Environment, School of Chemical and Biological Engineering,  Seoul National University, Seoul 151-742,  Korea.
authors.forename: Dae-Hyeong
authors.initials: DH
authors.lastname: Kim
authors.forename: Roozbeh
authors.initials: R
authors.lastname: Ghaffari
authors.forename: Nanshu
authors.initials: N
authors.lastname: Lu
authors.forename: Shuodao
authors.initials: S
authors.lastname: Wang
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Lee
authors.forename: Hohyun
authors.initials: H
authors.lastname: Keum
authors.forename: Robert
authors.initials: R
authors.lastname: D'Angelo
authors.forename: Lauren
authors.initials: L
authors.lastname: Klinker
authors.forename: Yewang
authors.initials: Y
authors.lastname: Su
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Lu
authors.forename: Yun-Soung
authors.initials: YS
authors.lastname: Kim
authors.forename: Abid
authors.initials: A
authors.lastname: Ameen
authors.forename: Yuhang
authors.initials: Y
authors.lastname: Li
authors.forename: Yihui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bassel
authors.initials: B
authors.lastname: de Graff
authors.forename: Yung-Yu
authors.initials: YY
authors.lastname: Hsu
authors.forename: Zhuangjian
authors.initials: Z
authors.lastname: Liu
authors.forename: Jeremy
authors.initials: J
authors.lastname: Ruskin
authors.forename: Lizhi
authors.initials: L
authors.lastname: Xu
authors.forename: Chi
authors.initials: C
authors.lastname: Lu
authors.forename: Fiorenzo G
authors.initials: FG
authors.lastname: Omenetto
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Huang
authors.forename: Moussa
authors.initials: M
authors.lastname: Mansour
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Slepian
authors.forename: John A
authors.initials: JA
authors.lastname: Rogers
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D057785:Catheters; D004582:Electronics, Medical / Q000295:instrumentation* / Q000379:methods; D022062:Electrophysiologic Techniques, Cardiac / Q000295:instrumentation*; D004867:Equipment Design / Q000379:methods; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D008422:Materials Testing; D036103:Nanotechnology / Q000379:methods; D010496:Pericardium / Q000033:anatomy & histology*; D019736:Prostheses and Implants; D011817:Rabbits; D012666:Semiconductors; D047011:Silk; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D047011:Silk