title: Effects of systemic administration or intrabursal injection of serotonin on puberty, first ovulation and follicular development in rats.
abstract: To elucidate the role of serotonin in the onset of puberty, the effects of both systemic and in-ovarian bursa administration of serotonin on the neuroendocrine mechanism that modulates the onset of puberty, follicular development and first ovulation were evaluated. Two experiments were carried out. For the first, 25 or 37.5 mg kg⁻¹ of bodyweight of serotonin creatinine sulfate was administered by a subcutaneous route to 30-day-old female rats. In the second experiment, serotonin creatinine sulfate was administered directly into the ovarian bursa of 34-day-old female rats. Systemic administration of 25 or 37.5 mg kg⁻¹ of serotonin creatinine sulfate induced a delay in the ages of vaginal opening and first vaginal oestrus, a decrease in the number of ovulating animals, and serum concentrations of FSH, LH, oestradiol and progesterone. An increase in the number of Class 3 (>500 μm) and atretic follicles was observed in the ovaries of these animals. The administration of serotonin creatinine sulfate in the ovarian bursa did not modify the onset of puberty and ovulation, but a reduced serum concentration of oestradiol was observed. Our results suggest that serotonin acts on the components of the hypothalamus-hypophysis-ovary axis by modulating follicular development, ovarian functions and the onset of puberty.
authors.affiliation: Unidad de Investigación en Biología de la Reproducción, Laboratorio de Pubertad. Facultad de Estudios Superiores Zaragoza, UNAM. AP 9-020, CP 15000, México D.F., México.
authors.forename: M J
authors.initials: MJ
authors.lastname: Moran
authors.forename: M E
authors.initials: ME
authors.lastname: Ayala
authors.forename: E
authors.initials: E
authors.lastname: Gallegos
authors.forename: J
authors.initials: J
authors.lastname: Romero
authors.forename: R
authors.initials: R
authors.lastname: Chavira
authors.forename: P
authors.initials: P
authors.lastname: Damián-Matsumura
authors.forename: R
authors.initials: R
authors.lastname: Domínguez
mesh_terms: D000818:Animals; D003404:Creatinine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004958:Estradiol / Q000097:blood / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D007279:Injections, Subcutaneous; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D009490:Neurosecretory Systems / Q000187:drug effects; D009866:Oogenesis / Q000187:drug effects*; D006080:Ovarian Follicle / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D010060:Ovulation / Q000187:drug effects*; D011374:Progesterone / Q000097:blood / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000008:administration & dosage* / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage* / Q000494:pharmacology; D012741:Sexual Maturation / Q000187:drug effects*; D014621:Vagina / Q000187:drug effects / Q000254:growth & development
chemical_list: D004338:Drug Combinations; D017366:Serotonin Receptor Agonists; C014050:creatinine sulfate, serotonin drug combination; D012701:Serotonin; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003404:Creatinine