title: Magnetic anisotropy considerations in magnetic force microscopy studies of single superparamagnetic nanoparticles.
abstract: In recent years, superparamagnetic nanoparticles (SPNs) have become increasingly important in applications ranging from solid state memory devices to biomedical diagnostic and therapeutic tools. However, detection and characterization of the small and unstable magnetic moment of an SPN at the single particle level remains a challenge. Further, depending on their physical shape, crystalline structure or orientation, SPNs may also possess magnetic anisotropy, which can govern the extent to which their magnetic moments can align with an externally applied magnetic field. Here, we demonstrate how we can exploit the magnetic anisotropy of SPNs to enable uniform, highly-sensitive detection of single SPNs using magnetic force microscopy (MFM) in ambient air. Superconducting quantum interference device magnetometry and analytical transmission electron microscopy techniques are utilized to characterize the collective magnetic behavior, morphology and composition of the SPNs. Our results show how the consideration of magnetic anisotropy can enhance the ability of MFM to detect single SPNs at ambient room temperature with high force sensitivity and spatial resolution.
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Tanya M
authors.initials: TM
authors.lastname: Nocera
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Murray
authors.forename: Gunjan
authors.initials: G
authors.lastname: Agarwal
mesh_terms: D016880:Anisotropy; D003911:Dextrans / Q000737:chemistry*; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008422:Materials Testing; D018625:Microscopy, Atomic Force / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size
chemical_list: D003911:Dextrans; D058185:Magnetite Nanoparticles; C097921:ferumoxtran-10