title: Influence of glycemic variability on the HbA1c level in elderly male patients with type 2 diabetes.
abstract: OBJECTIVE
  To investigate the influence of glycemic variability on the HbA1c level in elderly male patients with type 2 diabetes (T2DM).
  
  
  METHODS
  The 24-h glucose profiles were obtained using a continuous glucose monitoring system in 291 elderly male type 2 diabetic patients. The relationship between the glycemic variability and HbA1c level was assessed in these patients.
  
  
  RESULTS
  The mean amplitude of glycemic excursions (MAGE) in patients with HbA1c ≥7.0% was significantly higher than in patients with HbA1c <7.0% (4.33±1.67 vs. 3.48±1.46 mmol/L, p<0.001). A simple (Pearson's) correlation analysis indicated that the MAGE was significantly correlated with the HbA1c (r=0.229, p<0.001). Compared with the lowest quartile, the highest quartile of the MAGE was associated with a significantly increased risk of having a HbA1c ≥7.0% after multiple adjustments (p (for trend) <0.001).
  
  
  CONCLUSIONS
  The glycemic variability had a significant influence on the HbA1c level in elderly male patients with T2DM. The present data suggests that patients with higher glycemic variability might have higher HbA1c levels.
authors.affiliation: Department of Geriatric Endocrinology, Chinese PLA General Hospital, China.
authors.forename: Fu-Sheng
authors.initials: FS
authors.lastname: Fang
authors.forename: Zhi-Bing
authors.initials: ZB
authors.lastname: Li
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Tian
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Cheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism*; D015190:Blood Glucose Self-Monitoring; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human