title: [Medical therapy of osteoporosis in patients with mildly to moderate decreased renal function].
abstract: Both chronic kidney disease and osteoporosis are frequent conditions in the general population. Most drugs for treating osteoporosis seem safe in terms of affecting renal function for patients with mildly to moderate decreased renal function. There are very few data on the efficacy (reduction in fracture risk) or safety in patients with severely decreased renal function (glomerular filtration rate < 30 ml/min) or on dialysis.
authors.affiliation: Kardiologisk-nefrologisk-endokrinologisk Afdeling H, Hillerød Hospital, Dyrehavevej 29, Hillerød. piei@hih.regionh.dk
authors.forename: Pia A
authors.initials: PA
authors.lastname: Eiken
authors.forename: Peter
authors.initials: P
authors.lastname: Vestergaard
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D002118:Calcium / Q000378:metabolism; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism; D008657:Metabolic Clearance Rate; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D058866:Osteoporotic Fractures / Q000000981:diagnostic imaging; D010281:Parathyroid Hormone / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D053245:RANK Ligand / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D011859:Radiography; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000150:complications* / Q000378:metabolism; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D013324:Strontium / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D010281:Parathyroid Hormone; D053245:RANK Ligand; D020845:Selective Estrogen Receptor Modulators; D002118:Calcium; D013324:Strontium