title: Anti-β2 glycoprotein I antibodies and pregnancy outcome in antiphospholipid syndrome.
abstract: The relation between pregnancy outcome and single- or double-positivity of anticardiolipin (aCL) and β2 glycoprotein I (aβ2GPI) in antiphospholipid syndrome (APS) has yet to be clearly documented. In this article, a total of 191 lupus anticoagulant-negative pregnant women with primary APS were retrospectively divided into three groups: aCL(+) /aβ2GPI(-) ; aCL(+) /aβ2GPI(+) ; aCL(-) /aβ2GPI(+) . All women had received medical therapy consisting of prednisone (10-15 mg/day), low-dose aspirin (50 mg/day), and low molecular weight heparin (40 mg/day). The miscarriage rate in the double-positive group was significantly higher than that in the aCL(+) /aβ2GPI(-) group (46.2% vs. 22.1%, p < 0.05); the miscarriage rate in the aCL(-) /aβ2GPI(+) group (36.4%) was not significantly different from the rates of the other two groups (p > 0.05). Thus, double-positivity may be a risk factor for pregnancy loss and aβ2GPI antibody may be a better prognostic marker than aCL antibody for pregnancy outcome.
authors.affiliation: Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Xin Li
authors.initials: XL
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Xiao
authors.forename: Fufan
authors.initials: F
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis* / Q000276:immunology; D017153:Antibodies, Anticardiolipin / Q000032:analysis / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000276:immunology*; D005260:Female; D006801:Humans; D011241:Prednisone / Q000008:administration & dosage; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult; D053482:beta 2-Glycoprotein I / Q000276:immunology*
chemical_list: D000906:Antibodies; D017153:Antibodies, Anticardiolipin; D053482:beta 2-Glycoprotein I; D011241:Prednisone