title: Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population.
abstract: BACKGROUND
  Inherited functional single nucleotide polymorphisms (SNPs) in DNA repair genes may alter DNA repair capacity and thus contribute to cancer risk.
  
  
  METHODS
  Three ERCC1 functional SNPs (rs2298881C>A, rs3212986C>A and rs11615G>A) and two XPF/ERCC4 functional SNPs (rs2276466C>G and rs6498486A>C) were genotyped for 1125 gastric adenocarcinoma cases and 1196 cancer-free controls by Taqman assays. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate risk associations, and false-positive report probabilities (FPRP) were calculated for assessing significant findings.
  
  
  RESULTS
  ERCC1 rs2298881C and rs11615A variant genotypes were associated with increased gastric cancer risk (adjusted OR=1.33, 95% CI=1.05-1.67 for rs2298881 AC/CC and adjusted OR=1.23, 95% CI=1.05-1.46 for rs11615 AG/AA, compared with their common genotype AA and GG, respectively). Patients with 2-3 ERCC1 risk genotypes had significant increased risk (adjusted OR=1.56, 95% CI=1.27-1.93), compared with those with 0-1 ERCC1 risk genotypes, and this risk was more significantly in subgroups of never drinkers, non-gastric cardia adenocarcinoma (NGCA) and clinical stage I+II. All these risks were not observed for XPF SNPs.
  
  
  CONCLUSIONS
  These findings suggest that functional ERCC1 SNPs may contribute to risk of gastric cancer. Larger and well-designed studies with different ethnic populations are needed to validate our findings.
authors.affiliation: Cancer Research Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Qiu
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhou
authors.forename: Meng-Hong
authors.initials: MH
authors.lastname: Sun
authors.forename: Jiu-Cun
authors.initials: JC
authors.lastname: Wang
authors.forename: Ya-Jun
authors.initials: YJ
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Jin
authors.forename: Qing-Yi
authors.initials: QY
authors.lastname: Wei
authors.forename: Yanong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C095888:xeroderma pigmentosum group F protein; C071447:ERCC1 protein, human; D004720:Endonucleases