title: Prognostic factors in gastrointestinal stromal tumors: multicenter experience of 333 cases from Turkey.
abstract: OBJECTIVE
  Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract. In an attempt to survey the approximate incidence, clinicopathological characteristics, and immunophenotypic features of GISTs in Turkey, we conducted a clinicopathological and immunohistochemical analysis of GISTs.
  
  
  METHODS
  Three hundred and thirty-three patients with GIST from nine institutions in Turkey were retrospectively evaluated.
  
  
  RESULTS
  Between January 2001 and March 2011, a total of 333 patients with GISTs were included; of these, 204 (61.2%) were male and 129 (38.8%) were female. The median age was 55 years (range; 22-102 years). At the median follow-up of 26 months (range; 4-166 months), the 1-, 3- and 5-year OS rates of the 333 patients were 96.9%, 85.8% and 78.5%, respectively. The 5-year DFS rate was 40%. The 5-year OS rate and median OS time for the patients with R0 resection were significantly higher than for patients with metastatic diseases (79.7 vs. 75.7% and not reached vs. 115 months, respectively, p=0.04).
  
  
  CONCLUSIONS
  Although our results should be confirmed by prospective studies, we believe that they contribute to the literature because the study included both resectable and metastatic or unresectable GIST patients and multicenter findings from Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Seker
authors.forename: Alper
authors.initials: A
authors.lastname: Sevinc
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yildiz
authors.forename: Sener
authors.initials: S
authors.lastname: Cihan
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Kaplan
authors.forename: Ayse
authors.initials: A
authors.lastname: Gokdurnali
authors.forename: Faysal
authors.initials: F
authors.lastname: Dane
authors.forename: Emel
authors.initials: E
authors.lastname: Yaman
authors.forename: Halit
authors.initials: H
authors.lastname: Karaca
authors.forename: Dilsen
authors.initials: D
authors.lastname: Colak
authors.forename: Ummugul
authors.initials: U
authors.lastname: Uyeturk
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bilici
authors.forename: Nuriye Yildirim
authors.initials: NY
authors.lastname: Ozdemir
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Kalender
authors.forename: Dogan
authors.initials: D
authors.lastname: Uncu
authors.forename: Taflan
authors.initials: T
authors.lastname: Salepci
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Isikdogan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Benekli
authors.forename: Metin
authors.initials: M
authors.lastname: Ozkan
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gumus
authors.forename: Ugur
authors.initials: U
authors.lastname: Coskun
authors.forename: Celalettin
authors.initials: C
authors.lastname: Camci
authors.forename: Berna
authors.initials: B
authors.lastname: Oksuzoglu
authors.forename: Suleyman
authors.initials: S
authors.lastname: Buyukberber
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D046152:Gastrointestinal Stromal Tumors / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014421:Turkey / Q000453:epidemiology