title: Treatment of ulcerative necrobiosis lipoidica with topical calcineurin inhibitor: case report and literature review.
abstract: BACKGROUND
  Ulcerative necrobiosis lipoidica (UNL) is an uncommon disease, which is frequently recalcitrant to available therapies. It is characterized by well-defined, ulcerated plaques with indurated borders and atrophic centers. Multiple therapeutic options have been described, with variable success rates.
  
  
  OBJECTIVE
  To report the efficacy of using topical tacrolimus in treating UNL.
  
  
  METHODS
  Topical tacrolimus was used in the treatment of two patients with UNL.
  
  
  RESULTS
  Topical tacrolimus is effective in treating UNL.
  
  
  CONCLUSIONS
  Topical tacrolimus is a reasonably effective choice in treating UNL.
authors.affiliation: Divison of Dermatology, University of Toronto, Toronto, ON. Dr.Binamer@gmail.com
authors.forename: Yousef
authors.initials: Y
authors.lastname: Binamer
authors.forename: Laura
authors.initials: L
authors.lastname: Sowerby
authors.forename: Therese
authors.initials: T
authors.lastname: El-Helou
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000369:Aged, 80 and over; D065095:Calcineurin Inhibitors; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D009335:Necrobiosis Lipoidica / Q000150:complications / Q000188:drug therapy*; D012883:Skin Ulcer / Q000150:complications / Q000188:drug therapy; D016559:Tacrolimus / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D016559:Tacrolimus