title: Follow-up of primary Sjogren's syndrome patients presenting positive anti-cyclic citrullinated peptides antibody.
abstract: Anti-cyclic citrullinated peptide antibody (anti-CCP antibody) is very useful for the diagnosis of rheumatoid arthritis (RA) and is associated with articular erosions. The specificity of anti-CCP antibody in the diagnosis of RA has been reported to be about 95 %. Because of its higher specificity in RA, we assessed the clinical features of primary Sjogren's syndrome (pSS) who were positive for anti-CCP antibody. We assessed the clinical features of 405 pSS patients. After 60 (range 7-98) months, 23 (5.6 %) patients previously diagnosed with pSS had progressed to RA. Comparing the anti-CCP positive group with the negative group, laboratory test results for anti-CCP titer and rheumatoid factor positivity with respect to clinical outcome and progression to RA, arthralgia and arthritis were significantly different. Multivariate regression analysis also showed that anti-CCP antibody titer was independently associated with progression to RA. The odds ratio of anti-CCP positivity in terms of progression to RA was 2.5 (95 % CI 1.7-3.7). Testing for anti-CCP antibody in pSS patients with arthritis may allow for the prediction of progression to RA.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University School of Medicine, Bucheon, Korea.
authors.forename: Yang-Seon
authors.initials: YS
authors.lastname: Ryu
authors.forename: Sung-Hwan
authors.initials: SH
authors.lastname: Park
authors.forename: Jennifer
authors.initials: J
authors.lastname: Lee
authors.forename: Seung-Ki
authors.initials: SK
authors.lastname: Kwok
authors.forename: Ji-Hyeon
authors.initials: JH
authors.lastname: Ju
authors.forename: Ho-Youn
authors.initials: HY
authors.lastname: Kim
authors.forename: Chan-Hong
authors.initials: CH
authors.lastname: Jeon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000175:diagnosis; D001323:Autoantibodies / Q000097:blood*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide