title: [Folate status in Spanish schoolchildren and its association with parental smoking habits].
abstract: OBJECTIVE
  To study the folate status in a group of Spanish schoolchildren and its association with parental smoking habits.
  
  
  METHODS
  A group of 511 schoolchildren between 9 and 12 years old from Madrid (Spain) were studied. Parental smoking habits were self-reported by a questionnaire. Energy and nutrients intake (especially folates) were calculated with a "3-day diet record" and during two days (Monday and Tuesday) the food consumption was controlled in the school canteen using the "precise weighing method" (recording the weights of food served and leftovers on the plate). Folate intake of the sample was compared with the recommended intakes (RI) for this vitamin. Folate, vitamin B₁₂ and homocysteine were determined. Student's t-test, Mann Whitney Test, Pearson and Spearman correlation, ANCOVA, MANCOVA and multiple linear regression were applied for statistical analysis. Significance was set at P < 0.05.
  
  
  RESULTS
  Vegetable and fruit consumption, folate intake and its coverage to recommended folate intake (I/RI%) and serum folate levels were higher in children of nonsmoking mothers than in children of smoking mothers. Serum folate level in 13.3% of the children studied was below 6 ng/mL (moderate deficit), and in 0.26% was below 3 ng/mL (severe deficit). Taking into account others confounding factors a negative and significant correlation was observed between serum folate levels of children and smoking habits in mothers (r = -0.257, p = 0.01).
  
  
  CONCLUSIONS
  The maternal smoking habits might determine folate intake and serum folate levels on their offspring.
authors.affiliation: Departamento de Nutrición y Bromatología I, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, España. lggonzalezrdz@farm.ucm.es
authors.forename: L G
authors.initials: LG
authors.lastname: González-Rodríguez
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez-Rodríguez
authors.forename: J M
authors.initials: JM
authors.lastname: Perea
authors.forename: P
authors.initials: P
authors.lastname: Estaire
authors.forename: R M
authors.initials: RM
authors.lastname: Ortega
mesh_terms: D000886:Anthropometry; D002648:Child; D004032:Diet; D005220:Fathers; D005260:Female; D005492:Folic Acid / Q000032:analysis*; D005638:Fruit; D006801:Humans; D008297:Male; D009035:Mothers; D018673:Nutrition Policy; D009752:Nutritional Status; D010290:Parents; D012907:Smoking / Q000378:metabolism*; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D014675:Vegetables
chemical_list: D014028:Tobacco Smoke Pollution; D005492:Folic Acid