title: The M235T polymorphism in the angiotensinogen gene and heart failure: a meta-analysis.
abstract: BACKGROUND
  The aim of the present study was to assess the association between M235T polymorphism and heart failure using a meta-analysis.
  
  
  METHODS
  A literature search of Google Scholar, PubMed, the Cochrane Library and the China National Knowledge Infrastructure database (January 1990-April 2012) was performed for relevant studies. Statistical analyses were carried out using the Stata 12.0 to combine all the relevant studies. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated in a fixed-effects model and a random-effects model when appropriate. The pooled ORs were performed under the allelic contrast (T vs M), the dominant (TT + MT vs. MM) and the recessive models (TT vs MT + MM). Begg's test was used to measure publication bias.
  
  
  RESULTS
  A total of six case-control studies including 842 patients and 1054 controls were enrolled in this meta-analysis. Overall, there was a significant association between angiotensinogen (AGT) gene M235T polymorphism and risk of heart failure in the subgroup analysis under the allelic contrast (T vs M: OR = 1.48, 95% CI: 1.04-2.11) and the dominant model (TT+MT vs MM: OR=1.67, 95% CI: 1.13-2.46) in the Caucasian population.
  
  
  CONCLUSIONS
  The current meta-analysis suggests that M235T polymorphism might be associated with increased risk of heart failure in Caucasians.
authors.affiliation: Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, China.
authors.forename: Song
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Emergency Department, Red Cross Center Hospital of Harbin, China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, China.
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, China.
authors.forename: Xue-Qi
authors.initials: XQ
authors.lastname: Li
authors.affiliation: Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, China drzhanglili@163.com.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D044466:Asian People; D044383:Black People; D016022:Case-Control Studies; D005799:Genes, Dominant; D005808:Genes, Recessive; D006333:Heart Failure / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk; D044465:White People
chemical_list: D000808:Angiotensinogen