title: Catalytic [4+2] cyclization of α,β-unsaturated acyl chlorides with 3-alkylenyloxindoles: highly diastereo- and enantioselective synthesis of spirocarbocyclic oxindoles.
abstract: Cinchona alkaloids were used as Lewis base catalysts in the title reaction. The [4+2] cyclization of α,β-unsaturated acyl chlorides with electron-deficient alkenes derived from oxindole gave the corresponding spirocarbocyclic oxindoles.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, China.
authors.forename: Li-Tao
authors.initials: LT
authors.lastname: Shen
authors.forename: Wen-Qiang
authors.initials: WQ
authors.lastname: Jia
authors.forename: Song
authors.initials: S
authors.lastname: Ye
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D000078183:Oxindoles; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006846:Hydrocarbons, Halogenated; D007211:Indoles; D000078183:Oxindoles; D013141:Spiro Compounds; C022960:2-oxindole