title: Exocrine pancreatic insufficiency in the dog: breed associations, nutritional considerations, and long-term outcome.
abstract: Canine exocrine pancreatic insufficiency (EPI) is an alimentary tract disorder causing malabsorption and debilitations in affected individuals. This article covers predisposing factors to EPI and response to therapy. Although relatively easy to diagnose, knowledge of breed predispositions (and also of those breeds where the disease is less common) can guide the clinician. Numerous studies have examined therapy for EPI, and a key finding is the variability in response among affected dogs. This implies that close monitoring and individual tailoring of therapy is needed to maximize the chance of success. Important factors affecting outcome are the choice of enzyme preparation, presence of hypocobalaminemia, and the response to the first 2 to 3 months of therapy.
authors.affiliation: Department of Obesity and Endocrinology and School of Veterinary Science, University of Liverpool, Neston, United Kingdom. ajgerman@liv.ac.uk
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: German
mesh_terms: D000367:Age Factors; D000818:Animals; D001947:Breeding; D004032:Diet / Q000662:veterinary*; D019587:Dietary Supplements; D004283:Dog Diseases / Q000235:genetics* / Q000628:therapy*; D004285:Dogs; D057487:Enzyme Therapy; D010188:Exocrine Pancreatic Insufficiency / Q000235:genetics / Q000628:therapy / Q000662:veterinary*; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D010184:Pancreatic Extracts / Q000627:therapeutic use; D012737:Sex Factors; D016896:Treatment Outcome
chemical_list: D010184:Pancreatic Extracts