title: Visfatin and its role in obesity development.
abstract: Visfatin, a product of PBEF gene, is an adipocytokine that harbours strong insulin-mimetic activity and it has been reported previously to associate with obesity. Recent reports also provide evidence that Visfatin has also important intracellular effects as it is homologous with nicotinamide phosphoribosyltransferase (NAMPT). In this review, we summarize the main documented effects of Visfatin on metabolism in humans, with special emphasis put on the pathways associated with obesity.
authors.affiliation: Department of Pathological Physiology, Masaryk University, Czech Republic. opravdu.stastny@seznam.cz
authors.forename: Jiri
authors.initials: J
authors.lastname: Stastny
authors.forename: Julie
authors.initials: J
authors.lastname: Bienertova-Vasku
authors.forename: Anna
authors.initials: A
authors.lastname: Vasku
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism* / Q000494:pharmacology; D009765:Obesity / Q000378:metabolism*
chemical_list: D016207:Cytokines; D008055:Lipids; D054409:Nicotinamide Phosphoribosyltransferase