title: Strategies to query and display allergy-derived epitope data from the immune epitope database.
abstract: The recognition of specific epitopes on allergens by antibodies and T cells is a key element in allergic processes. Analysis of epitope data may be of interest for basic immunopathology or for potential application in diagnostics or immunotherapy. The Immune Epitope Database (IEDB) is a freely available repository of epitope data from infectious disease agents, as well as epitopes defined for allergy, autoimmunity, and transplantation. The IEDB curates the experiments associated with each epitope and thus provides a variety of different ways to search the data. This review aims to demonstrate the utility of the IEDB and its query strategies, including searching by epitope structure (peptidic/nonpeptidic), by assay methodology, by host, by the allergen itself, or by the organism from which the allergen was derived. Links to tools for visualization of 3-D structures, epitope prediction, and analyses of B and T cell reactivity by host response frequency score are also highlighted.
authors.affiliation: Immune Epitope Database and Analysis Resource (IEDB), La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. kvaughan@liai.org
authors.forename: Kerrie
authors.initials: K
authors.lastname: Vaughan
authors.forename: Bjoern
authors.initials: B
authors.lastname: Peters
authors.forename: Mark
authors.initials: M
authors.lastname: Larche
authors.forename: Anna
authors.initials: A
authors.lastname: Pomes
authors.forename: David
authors.initials: D
authors.lastname: Broide
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sette
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D018360:Crystallography, X-Ray; D003626:Data Display; D016208:Databases, Factual; D030562:Databases, Protein; D003888:Desensitization, Immunologic; D000939:Epitopes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008213:Lymphocyte Activation; D010455:Peptides / Q000276:immunology; D011506:Proteins / Q000737:chemistry / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000485:Allergens; D000939:Epitopes; D018984:Epitopes, T-Lymphocyte; D010455:Peptides; D011506:Proteins