title: The correlation between insulin-like growth factor II mRNA binding protein 3 expression in hepatocellular carcinoma and prognosis.
abstract: OBJECTIVE
  The study aims to explore the expression of IMP3 in HCC and the correlation between its expression and prognosis.
  
  
  METHODS
  We collected several clinical and pathological files including 92 cases of HCC and 58 cases of adjacent liver tissues. Expression of IMP3 in these tissues was detected by immunohistochemistry, while compared with clinicopathological characteristics and expression of Ki-67. A χ2 test was used to analyze the relationship between expression of IMP3 and clinicοpathologic factors. The Kaplan-Meier survival curve was used to calculate survival rate. A Cox analysis was used to evaluate the relationship between index and patients’ lifetime.
  
  
  RESULTS
  The positive rate of IMP3 in HCC tissues was significantly higher than that in adjacent tissues. The expression of IMP3 was related to the histological differentiation of HCC, metastasis, the stage of ACJJ, the expression of Ki-67 and survival. The ACJJ stage, metastases and the expression of IMP3 were independent factors for the HCC patients’ survival.
  
  
  CONCLUSIONS
  IMP3, which is associated with tumor formation, invasion, tumor cell proliferation and so on, may become the target for inhabiting cell proliferation and the biomarker for predicting prognosis.
authors.affiliation: Department of Liver Transplantation Surgery, Xin Hua Hopsital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Li-tian
authors.initials: LT
authors.lastname: Chen
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Lin
authors.forename: Lin-lin
authors.initials: LL
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000737:chemistry* / Q000401:mortality / Q000556:secondary / Q000601:surgery; D002454:Cell Differentiation; D016009:Chi-Square Distribution; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000032:analysis; D008113:Liver Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D016601:RNA-Binding Proteins / Q000032:analysis*; D012307:Risk Factors; D013997:Time Factors; D046888:Tissue Array Analysis; D016896:Treatment Outcome; D015854:Up-Regulation; D055815:Young Adult
chemical_list: C498780:IGF2BP3 protein, human; D019394:Ki-67 Antigen; D016601:RNA-Binding Proteins