title: [Clinicopathologic features and prognostic analyses of Borrmann type IV gastric cancer].
abstract: OBJECTIVE
  To compare Borrmann type IV gastric cancer with other types of cancer and explore their clinicopathological features and prognostic factors.
  
  
  METHODS
  We retrospectively reviewed the medical records of 893 consecutive advanced gastric cancer patients. They were divided into 2 groups: Borrmann type IV (n = 139) and other macroscopic Borrmann types of cancer (n = 754). Their clinicopathologic characteristics and overall survival data were analyzed.
  
  
  RESULTS
  Borrmann type IV gastric cancer was found to be associated with more advanced and unfavorable clinicopathological features. The incidence of preoperative biopsy-negative rate of Borrmann type IV gastric cancer was much higher (15.9%) than other Borrmann types of gastric cancer. The 5-year survival rate of Borrmann type IV cancer patients was 9.9% and it was significantly lower than that of other types. Moreover, the 5-year survival rate was higher in the patients with curative resection (18.7%) (P < 0.05). Stratified analysis revealed that when the tumor TNM stages were of II, III, the survival data of Borrmann type IV cancer were worse than others. Multivariate analyses revealed distant metastasis and curability were independent prognostic factors for Borrmann type IV gastric cancer.
  
  
  CONCLUSIONS
  Borrmann type IV carcinoma has poor clinicopathological features and survival rate compared with other types. An early detection and curative resection may improve the prognosis for the patients with Borrmann type IV cancer.
authors.affiliation: Department of Gastrointestinal Surgery, Sun Yat-sen University, Guangzhou, China.
authors.forename: Jin-ping
authors.initials: JP
authors.lastname: Ma
authors.forename: Jian-hui
authors.initials: JH
authors.lastname: Chen
authors.forename: Shi-rong
authors.initials: SR
authors.lastname: Cai
authors.forename: Chuang-qi
authors.initials: CQ
authors.lastname: Chen
authors.forename: Dong-jie
authors.initials: DJ
authors.lastname: Yang
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.forename: Yu-long
authors.initials: YL
authors.lastname: He
authors.forename: Wen-hua
authors.initials: WH
authors.lastname: Zhan
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000473:pathology*; D015996:Survival Rate