title: NLRC5: a key regulator of MHC class I-dependent immune responses.
abstract: The expression of MHC class I molecules is crucial for the initiation and regulation of adaptive immune responses against pathogens. NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes (CITA). NLRC5 and the master regulator for MHC class II genes, class II transactivator (CIITA), interact with similar MHC promoter-bound factors. Here, we provide a broad overview of the molecular mechanisms behind MHC class I transcription and the role of the class I transactivator NLRC5 in MHC class I-dependent immune responses.
authors.affiliation: Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A&M Health Science Center, College Station, Texas 77843, USA. kobayashi@medicine.tamhsc.edu
authors.forename: Koichi S
authors.initials: KS
authors.lastname: Kobayashi
authors.forename: Peter J
authors.initials: PJ
authors.lastname: van den Elsen
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics / Q000276:immunology*; D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics / Q000276:immunology; D005805:Genes, MHC Class I / Q000235:genetics / Q000276:immunology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000276:immunology; D015534:Trans-Activators / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C083728:MHC class II transactivator protein; C548042:NLRC5 protein, human; C549161:NLRC5 protein, mouse; D009687:Nuclear Proteins; D015534:Trans-Activators