title: The complex world of WNT receptor signalling.
abstract: 30 years after the identification of WNTs, their signal transduction has become increasingly complex, with the discovery of more than 15 receptors and co-receptors in seven protein families. The recent discovery of three receptor classes for the R-spondin family of WNT agonists further adds to this complexity. What emerges is an intricate network of receptors that form higher-order ligand-receptor complexes routing downstream signalling. These are regulated both extracellularly by agonists such as R-spondin and intracellularly by post-translational modifications such as phosphorylation, proteolytic processing and endocytosis.
authors.affiliation: Division of Molecular Embryology, DKFZ-ZMBH Alliance, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. C.Niehrs@imb-mainz.de
authors.forename: Christof
authors.initials: C
authors.lastname: Niehrs
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000378:metabolism; D004705:Endocytosis; D005260:Female; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D011499:Protein Processing, Post-Translational; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000378:metabolism; D060490:Receptors, Wnt / Q000502:physiology*; D019699:Thrombospondins / Q000378:metabolism; D051153:Wnt Proteins / Q000502:physiology; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000378:metabolism
chemical_list: D019812:Heparan Sulfate Proteoglycans; D060490:Receptors, Wnt; D019699:Thrombospondins; D051153:Wnt Proteins; D051176:beta Catenin; D057050:Receptor Tyrosine Kinase-like Orphan Receptors