title: Elevated uric acid and functional mitral regurgitation in dilated cardiomyopathy.
abstract: BACKGROUND
  Recent findings suggest that there is a close relationship between chronic heart failure and uric acid.
  
  
  OBJECTIVE
  The aim of the study was to assess whether increased uric acid levels in patients with dilated cardiomyopathy might correlate with the degree of functional mitral regurgitation (MR).
  
  
  METHODS
  Sixty two consecutive patients diagnosed with dilated cardiomyopathy were included in the study. The patients were classified according to severity of functional MR into two groups: mild-moderate functional MR (ERO < 0.2 cm2) and severe functional MR.
  
  
  RESULTS
  The patients with severe functional MR had significantly higher serum uric acid levels compared to patients without severe functional MR (6.34 ± 1.61 mg/dL vs 5.43 ± 1.17 mg/dL respectively, p = 0.012). Furthermore, tenting area, an important predictor of functional MR severity, was moderately correlated with the serum uric acid levels (r = 0.351, p = 0.005). It was also shown that the serum uric acid concentrations were inversely correlated with left ventricular (LV) ejection fraction, and positively correlated with LV volumes. There was also a significant relation between the serum uric acid and left atrial volumes and also brain natriuretic peptide (BNP) levels.
  
  
  CONCLUSIONS
  In conclusion, this study demonstrates that elevated serum uric acid levels in patients with dilated cardiomyopathy are correlated with the severity of functional MR and echocardiographic volume indices.
authors.affiliation: Department of Cardiology, Kartal Kosuyolu Yuksek Ihtisas Heart-Education and Research Hospital, Istanbul, Turkey.
authors.forename: M V
authors.initials: MV
authors.lastname: Yazicioğlu
authors.forename: A
authors.initials: A
authors.lastname: Avci
authors.forename: G
authors.initials: G
authors.lastname: Açar
authors.forename: Ö
authors.initials: Ö
authors.lastname: Esen
authors.forename: O
authors.initials: O
authors.lastname: Karaca
authors.forename: G
authors.initials: G
authors.lastname: Alici
authors.forename: B
authors.initials: B
authors.lastname: Özkan
authors.forename: E
authors.initials: E
authors.lastname: Alizade
authors.forename: M
authors.initials: M
authors.lastname: Bulut
authors.forename: M
authors.initials: M
authors.lastname: Akçakoyun
authors.forename: A M
authors.initials: AM
authors.lastname: Esen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000150:complications; D004452:Echocardiography / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000097:blood* / Q000150:complications; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D012720:Severity of Illness Index; D014527:Uric Acid / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D014527:Uric Acid