title: Role of surrogate markers in assessment of insulin resistance in females with thyroid disorders.
abstract: BACKGROUND
  Thyroid status is known to affect insulin sensitivity although conflicting data have been reported regarding hypothyroid and hyperthyroid states. Assessment of insulin resistance is difficult, therefore we compared homeostasis model assessment (HOMA), glucose to insulin (G:I) ratio, glucose to C-peptide (G:C) ratio and ferritin of hypothyroid and hyperthyroid subjects with euthyroid, euglycemic subjects.
  
  
  METHODS
  The study group comprised of 40 hypothyroid, 25 hyperthyroid female subjects and 40 euthyroid controls. Serum samples of all the patients were assayed for thyroid profile, glucose, Insulin, C-peptide and ferritin. Homeostasis model of assessment (HOMA-IR), (G:I), (G:C) and ferritin were employed as surrogate measures to assess the level of insulin resistance. The area under the curves for the surrogate markers was determined from the receiver operating characteristics (ROC) curves for the hypothyroid and hyperthyroid patients.
  
  
  RESULTS
  Patients with hypothyroidism demonstrated insulin resistance as observed by the higher HOMA-IR and G:I ratio as compared to the controls whereas insulin resistance was not detected in the hyperthyroid patients in our study.
  
  
  CONCLUSIONS
  Thyroid dysfunction attributes to deranged glucose metabolism. Assessment of the surrogate markers might prove to be beneficial in detecting insulin resistance at the incipient stages and subsequent management.
authors.affiliation: Department of Biochemistry, Lady Hardinge Medical College, New Delhi 110001, India. binita.dr@gmail.com
authors.forename: Binita
authors.initials: B
authors.lastname: Goswami
authors.forename: Bhawna
authors.initials: B
authors.lastname: Singh
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood*; D006706:Homeostasis; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000453:epidemiology; D007037:Hypothyroidism / Q000097:blood* / Q000453:epidemiology; D007194:India / Q000453:epidemiology; D007333:Insulin Resistance; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002096:C-Peptide; D005293:Ferritins