title: Glucagon-like peptide-2 stimulates mucosal microcirculation measured by laser Doppler flowmetry in end-jejunostomy short bowel syndrome patients.
abstract: BACKGROUND
  In animal and human studies glucagon-like peptide-2 (GLP-2) has been shown to increase blood flow in the superior mesenteric artery and the portal vein. This study describes the effect of GLP-2 measured directly on the intestinal mucosal blood flow by laser Doppler flowmetry (LDF) in end-jejunostomy short bowel syndrome (SBS) patients.
  
  
  METHODS
  In five SBS patients with end-jejunostomy a specially designed laser Doppler probe was inserted into the stoma nipple, and blood flow measured directly on the jejunal mucosa for 105 min in relation to no treatment, systemic saline infusion, topical adrenaline application and a subcutaneous injection of 800 μg native GLP-2.
  
  
  RESULTS
  The GLP-2 injection increased jejunal mucosal blood flow by 79±37% compared to conditions, where no treatment was given (p<0.001). The significant effect was present at least 105 min. Systemic saline infusion and topical, mucosal adrenaline application did not affect mucosal microcirculation.
  
  
  CONCLUSIONS
  GLP-2 raises jejunal microcirculation in SBS patients with end-jejunostomy. This may explain the redness and increase in the end-jejunostomy nipple size imminently after commencing GLP-2 injections. The potential beneficial effects of this GLP-2-mediated increase of blood flow in the mesenteric bed should be investigated in clinical conditions other than the short bowel syndrome.
authors.affiliation: Department of Gastroenterology CA-2121, Copenhagen University Hospital, Rigshospitalet, Denmark. hoyerup@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Høyerup
authors.forename: P M
authors.initials: PM
authors.lastname: Hellström
authors.forename: P T
authors.initials: PT
authors.lastname: Schmidt
authors.forename: C F
authors.initials: CF
authors.lastname: Brandt
authors.forename: C
authors.initials: C
authors.lastname: Askov-Hansen
authors.forename: P B
authors.initials: PB
authors.lastname: Mortensen
authors.forename: P B
authors.initials: PB
authors.lastname: Jeppesen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D053767:Glucagon-Like Peptide 2 / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply*; D007583:Jejunum / Q000503:physiopathology* / Q000601:surgery; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D010865:Pilot Projects; D012778:Short Bowel Syndrome / Q000503:physiopathology* / Q000601:surgery
chemical_list: D053767:Glucagon-Like Peptide 2