title: A case of hydroxyurea-induced leg ulcer after definitive treatment suspension in a patient affected by thrombocythemia: effectiveness of a new collagenase.
abstract: Hydroxyurea (HU) is an antitumor agent effective in the treatment of myeloproliferative disorders. It is usually well-tolerated and has low toxicity but its use is associated with several adverse cutaneous effects. Among them, leg ulcers have been noted in association with long-term administration. Poor response to traditional local and systemic therapy is a typical feature of HU-induced leg ulcers, and discontinuation of the drug is often required to achieve complete wound healing. We present a case of circumferential HU-induced leg ulcer in a patient affected by essential thrombocythemia, in which the lesion occured after the definitive suspension of the treatment. We propose a conservative management with a new collagenase (Bionect Start®) for skin lesions in this type of patient, for whom a surgical treatment could be more complicated, due to the underlying disease.
authors.affiliation: Department of Plastic Reconstructive and Aesthetic Surgery, Policlinico Umberto I, Sapienza, University of Rome, Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fioramonti
authors.forename: Pasquale
authors.initials: P
authors.lastname: Fino
authors.forename: Paola
authors.initials: P
authors.lastname: Parisi
authors.forename: Nicolo
authors.initials: N
authors.lastname: Scuderi
authors.forename: Maria G
authors.initials: MG
authors.lastname: Onesti
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D017364:Collagenases / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage / Q000009:adverse effects*; D007871:Leg Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D013922:Thrombocytosis / Q000188:drug therapy*; D014945:Wound Healing
chemical_list: D000970:Antineoplastic Agents; D017364:Collagenases; D006918:Hydroxyurea