title: [Vitamin D and chronic kidney disease: increasing role for an old vitamin].
abstract: Patients with chronic kidney disease exhibit a high mortality risk that is not fully explained by the classical cardiovascular risk factors. Vitamin D deficiency highly prevalent among CKD patients is independently associated with an increased mortality risk in this population. Advances in the understanding of vitamin D physiology dramatically changed the view on the role of this vitamin in kidney disease. Extra-renal actions on a variety of tissues have been identified. By its cardiovascular effects for instance, correction of vitamin D insufficiency might help to reduce the excess of mortality among patients with chronic kidney disease. This article summarizes the sum of knowledge on the roles of vitamin D in kidney disease. Recommendations on screening and substitution with vitamin D in this high-risk population are then proposed.
authors.affiliation: Service de néphrologie, Département des spécialités de médecine, HUG, 1211 Genève 14. Thomas.Ernandez@hcuge.ch
authors.forename: Thomas
authors.initials: T
authors.lastname: Ernandez
authors.forename: Catherine
authors.initials: C
authors.lastname: Stoermann-Chopard
mesh_terms: D018450:Disease Progression; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology; D017410:Practice Guidelines as Topic; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D013557:Switzerland / Q000453:epidemiology; D014807:Vitamin D / Q000008:administration & dosage*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D014807:Vitamin D