title: Enantioselective intermolecular [2 + 2 + 2] cycloadditions of ene-allenes with allenoates.
abstract: An enantioselective [2 + 2 + 2] cycloaddition of ene-allenes with allenoates is described, which transforms simple π-components into stereochemically complex carbocycles in a single step. The rhodium(I)-catalyzed cycloaddition proceeds with good levels of enantioselectivity, and with high levels of regio-, chemo-, and diastereoselectivity. Our results are consistent with a mechanism involving an enantioselective intermolecular allene-allene oxidative coupling.
authors.affiliation: Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Brusoe
authors.forename: Rahul V
authors.initials: RV
authors.lastname: Edwankar
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Alexanian