title: Facile synthesis of graphene hybrid tube-like structure for simultaneous detection of ascorbic acid, dopamine, uric acid and tryptophan.
abstract: In the present work, a tube-like structure of graphene hybrid as modifier to fabricate electrode for simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA) and tryptophan (Trp) was reported. The hybrid was synthesized by a simple method based on graphene sheets (GS) and 3,4,9,10-perylenetetracarboxylic acid (PTCA) via π-π stacking interaction under ultrasonic condition. The combination of GS and PTCA could effectively improve the dispersion of GS, owing to PTCA with the carboxylic-functionalized interface. Comparing with pure GS or PTCA modified electrode, GS-PTCA displayed high catalytic activity and selectivity toward the oxidation of AA, DA, UA, and Trp. Moreover, cyclic voltammetry, different pulse voltammetry and scanning electron microscopy were employed to characterize the sensors. The experiment results showed that the linear response range for simultaneous detection of AA, DA, UA, and Trp were 20-420 μM, 0.40-374 μM, 4-544 μM and 0.40-138 μM, respectively, and the detection limits were 5.60 μM, 0.13 μM, 0.92 μM and 0.06 μM (S/N=3). Importantly, the proposed method offers promise for simple, rapid, selective and cost-effective analysis of small biomolecules.
authors.affiliation: Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Chai
authors.forename: Ruo
authors.initials: R
authors.lastname: Yuan
authors.forename: Shihong
authors.initials: S
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.forename: Dehua
authors.initials: D
authors.lastname: Yuan
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis*; D004298:Dopamine / Q000032:analysis*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D013997:Time Factors; D014364:Tryptophan / Q000032:analysis*; D014527:Uric Acid / Q000032:analysis*
chemical_list: D014527:Uric Acid; D006108:Graphite; D014364:Tryptophan; D001205:Ascorbic Acid; D004298:Dopamine