title: Orbital inflammatory disease: unusual presentation of enthesitis in an HLA-B27 spondyloarthropathy.
abstract: BACKGROUND
  Orbital inflammatory disease can complicate many systemic inflammatory disorders, including sarcoidosis, vasculitis, Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, myasthenia gravis and scleroderma, but has not been reported with spondyloarthropathies.
  
  
  METHODS
  The authors describe a 29-year-old woman who developed orbital myositis, in addition to anterior uveitis, sacroiliitis and peripheral arthritis, as a complication of an underlying HLA-B27 related spondyloarthropathy, which responded temporarily to corticosteroid therapy and more completely to adalimumab.
  
  
  CONCLUSIONS
  The patient reported herein presents with orbital inflammation as an extra-articular manifestation of HLA-B27 associated undifferentiated spondyloarthropathy. We propose that enthesitis is the likely mechanism of orbital inflammation in this patient.
authors.forename: Amrita
authors.initials: A
authors.lastname: Sachdeva
authors.forename: Neil
authors.initials: N
authors.lastname: Kramer
authors.forename: Elliot D
authors.initials: ED
authors.lastname: Rosenstein
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D015796:HLA-B27 Antigen / Q000276:immunology*; D006801:Humans; D016727:Orbital Pseudotumor / Q000175:diagnosis / Q000209:etiology*; D012216:Rheumatic Diseases / Q000150:complications* / Q000175:diagnosis; D012447:Sacrum; D025242:Spondylarthropathies / Q000150:complications* / Q000276:immunology
chemical_list: D015796:HLA-B27 Antigen