title: Resistance training in patients with limb-girdle and becker muscular dystrophies.
abstract: BACKGROUND
  In this study we investigated the effect of strength training in patients with limb-girdle muscular dystrophy (LGMD) and Becker muscular dystrophy (BMD).
  
  
  METHODS
  In 2 studies we compared the effect of low-intensity training (LOIT; n = 8) and high-intensity training (HIT; n = 4) in muscles of the upper and lower extremities. Patients were tested for maximal strength and endurance before and after the training program.
  
  
  RESULTS
  LOIT training over 6 months resulted in increased biceps strength and endurance. HIT training increased endurance and strength in wrist flexion and extension and in elbow flexion. One patient discontinued HIT training due to muscle soreness and mildly increased plasma CK levels without strength deterioration.
  
  
  CONCLUSIONS
  Both LOIT and HIT increased muscle strength and endurance in some of the muscles tested and were well tolerated in most patients. Our findings suggest that supervised resistance training may be considered in the management of patients with LGMD2 and BMD.
authors.affiliation: Neuromuscular Research Unit 3342, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. marielouise@sveen.dk
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Sveen
authors.forename: Søren P
authors.initials: SP
authors.lastname: Andersen
authors.forename: Lina H
authors.initials: LH
authors.lastname: Ingelsrud
authors.forename: Sarah
authors.initials: S
authors.lastname: Blichter
authors.forename: Niels E
authors.initials: NE
authors.lastname: Olsen
authors.forename: Simon
authors.initials: S
authors.lastname: Jønck
authors.forename: Thomas O
authors.initials: TO
authors.lastname: Krag
authors.forename: John
authors.initials: J
authors.lastname: Vissing
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D049288:Muscular Dystrophies, Limb-Girdle / Q000503:physiopathology / Q000628:therapy*; D020388:Muscular Dystrophy, Duchenne / Q000503:physiopathology / Q000628:therapy*; D010807:Physical Endurance / Q000502:physiology; D055070:Resistance Training / Q000379:methods*; D016896:Treatment Outcome