title: Roles of IL-10 in ocular inflammations: a review.
abstract: BACKGROUND
  This review represents the current in vitro, in vivo, animal and human investigations on the roles of IL-10 in ocular inflammatory conditions.
  
  
  METHODS
  The data sources were literature reviews, including Pub Med, Medline, and ISI databases (since 1989 to mid-2012). Search items were, IL-10, chemokines, cytokines, alone or in combination with, serum, aqueous, vitreous eye, ocular, ocular tissues, ophthalmic, and review.
  
  
  RESULTS
  Ocular effects of IL-10 depend on the sources of the secretion and sites of the action. IL-10 plays important anti-inflammatory and especially anti-angiogenic activities in ocular tissues such as the conjunctiva, cornea, retina, choroid, and orbit.
  
  
  CONCLUSIONS
  IL-10 plays major anti-inflammatory and anti-angiogenic roles in most of the ocular inflammations. Also, IL-10 plays a role in development of anterior chamber-associated immune deviation (ACAID). Any manipulation of IL-10 for treatment purposes should be considered very cautiously due to its potential hazards to the immune system.
authors.affiliation: Department of Ophthalmology, Shahed University, Tehran, Iran. ghasemi518@yahoo.com
authors.forename: Hassan
authors.initials: H
authors.lastname: Ghasemi
authors.forename: Tooba
authors.initials: T
authors.lastname: Ghazanfari
authors.forename: Roya
authors.initials: R
authors.lastname: Yaraee
authors.forename: Parviz
authors.initials: P
authors.lastname: Owlia
authors.forename: Zuhair Mohammad
authors.initials: ZM
authors.lastname: Hassan
authors.forename: Soghrat
authors.initials: S
authors.lastname: Faghihzadeh
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular; D016753:Interleukin-10 / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*; D014605:Uveitis / Q000276:immunology / Q000378:metabolism*
chemical_list: D016753:Interleukin-10