title: Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product.
abstract: Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.
authors.affiliation: Department of Chemistry and Nano Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Kim
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.forename: Alban R
authors.initials: AR
authors.lastname: Pereira
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Ban
authors.forename: Young Ji
authors.initials: YJ
authors.lastname: Yoo
authors.forename: Eunji
authors.initials: E
authors.lastname: Kim
authors.forename: Je Won
authors.initials: JW
authors.lastname: Park
authors.forename: David H
authors.initials: DH
authors.lastname: Sherman
authors.forename: William H
authors.initials: WH
authors.lastname: Gerwick
authors.forename: Yeo Joon
authors.initials: YJ
authors.lastname: Yoon
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification*; D000458:Cyanobacteria / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D005810:Multigene Family; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D001688:Biological Products; D013844:Thiazoles; C100545:barbamide