title: Fan-shaped body neurons are involved in period-dependent regulation of long-term courtship memory in Drosophila.
abstract: In addition to its established function in the regulation of circadian rhythms, the Drosophila gene period (per) also plays an important role in processing long-term memory (LTM). Here, we used courtship conditioning as a learning paradigm and revealed that (1) overexpression and knocking down of per in subsets of brain neurons enhance and suppress LTM, respectively, and (2) suppression of synaptic transmission during memory retrieval in the same neuronal subsets leads to defective LTM. Further analysis strongly suggests that the brain region critical for per-dependent LTM regulation is the fan-shaped body, which is involved in sleep-induced enhancement of courtship LTM.
authors.affiliation: Department of Biological Sciences, Tokyo Metropolitan University, Japan. sakai-takaomi@tmu.ac.jp
authors.forename: Takaomi
authors.initials: T
authors.lastname: Sakai
authors.forename: Show
authors.initials: S
authors.lastname: Inami
authors.forename: Shoma
authors.initials: S
authors.lastname: Sato
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kitamoto
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D003380:Courtship; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D057567:Memory, Long-Term / Q000502:physiology*; D024521:Mushroom Bodies / Q000166:cytology*; D009474:Neurons / Q000502:physiology*; D056950:Period Circadian Proteins / Q000235:genetics / Q000378:metabolism*; D012890:Sleep / Q000235:genetics; D009435:Synaptic Transmission / Q000235:genetics; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; C557617:GAL4 protein, Drosophila; C539040:PER protein, Drosophila; D056950:Period Circadian Proteins; D014157:Transcription Factors; D049452:Green Fluorescent Proteins