title: Functional magnetic resonance imaging of methamphetamine craving.
abstract: The study aimed to explore the abnormal activation of special brain areas associated with methamphetamine craving using functional magnetic resonance imaging (fMRI) and to reveal the neurobiological basis of addiction. Twenty-six methamphetamine addicts and 26 healthy subjects were scanned by brain fMRI while watching pictures of happy, sad, or methamphetamine to acquire resource data. SPM5 was used to analyze fMRI data to get related brain activation map, and it was found that methamphetamine addicts had high brain activation in cingulate and low activation in frontal lobe when watching methamphetamine-cue pictures. This study demonstrated that methamphetamine addicts had emotion-related brain activation abnormalities.
authors.affiliation: First Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Yin
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Ma
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.forename: Zhao-Xin
authors.initials: ZX
authors.lastname: Wang
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Le
authors.forename: Jin-Zhuang
authors.initials: JZ
authors.lastname: Huang
authors.forename: Ke-Ming
authors.initials: KM
authors.lastname: Fang
authors.forename: Ling-Min
authors.initials: LM
authors.lastname: Liao
authors.forename: Ze-Long
authors.initials: ZL
authors.lastname: Cai
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D019969:Amphetamine-Related Disorders / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D003463:Cues; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D055815:Young Adult