title: Flipping the script on macrophages in leiomyosarcoma.
abstract: Macrophages promote the growth of leiomyosarcoma (LMS), a malignant soft-tissue tumor. CD47 on tumor cells binds to the macrophagic receptor signal regulatory protein α (SIRPα) and prevents phagocytosis. We showed that anti-CD47 monoclonal antibodies (mAbs) allow macrophages to engulf LMS cells and prevent tumor growth and metastases. Therefore, anti-CD47 mAbs represent a promising targeted immunotherapy for LMS.
authors.affiliation: Department of Pathology; Stanford University School of Medicine; Stanford, CA USA ; Department of Genetics; Stanford University School of Medicine; Stanford, CA USA.
authors.forename: Badreddin
authors.initials: B
authors.lastname: Edris
authors.forename: Kipp
authors.initials: K
authors.lastname: Weiskopf
authors.forename: Irving L
authors.initials: IL
authors.lastname: Weissman
authors.forename: Matt
authors.initials: M
authors.lastname: van de Rijn