title: Synthesis of highly functionalized fluorinated cispentacin derivatives.
abstract: Fluorinated highly functionalized cispentacin derivatives were synthetised starting from an unsaturated bicyclic β-lactam through C=C bond functionalization via the dipolar cycloaddition of a nitrile oxide, isoxazoline opening, and fluorination by OH/F exchange.
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Szeged, HU-6720, Eötvös 6, Hungary.
authors.forename: Melinda
authors.initials: M
authors.lastname: Nonn
authors.forename: Loránd
authors.initials: L
authors.lastname: Kiss
authors.forename: Mikko M
authors.initials: MM
authors.lastname: Hänninen
authors.forename: Reijo
authors.initials: R
authors.lastname: Sillanpää
authors.forename: Ferenc
authors.initials: F
authors.lastname: Fülöp
mesh_terms: D003500:Cyclization; D003515:Cycloleucine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D054879:Halogenation; D009570:Nitriles / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D047090:beta-Lactams / Q000737:chemistry
chemical_list: D009570:Nitriles; D010087:Oxides; D047090:beta-Lactams; D003515:Cycloleucine; C065594:cispentacin