title: [Genetic polymorphisms as tool indicators for individual vulnerability to smoking behaviour].
abstract: OBJECTIVE
  In line with genetic and pharmacological studies suggesting that neurotransmitter pathways play a role in nicotine dependence, research was conducted in connection with 4 genetic polymorphisms: OPRM1, TPH1, ADRA2A and HTR1B. This study compares the genotype and allele frequencies in 3 groups (non-smokers, former smokers and smokers) of unrelated individuals (n=490) from Catalonia (north east Spain) in order to find any relationship.
  
  
  METHODS
  All polymorphisms were genotyped in each population group and statistical analysis was performed.
  
  
  RESULTS
  Data obtained show that there is a relationship between sex, age and the TPH1 locus, indicating a trend towards a lower frequency of the AA genotype in former smokers for the TPH1 locus.
  
  
  CONCLUSIONS
  The results indicate that a role is played by the TPH1 polymorphism as an indicator of therapeutic failure in smoking cessation.
authors.affiliation: Laboratorio de Genética, Unidad de Medicina Legal y Toxicología, Departamento de Salud Pública, Facultad de Medicina, Universidad de Barcelona, Barcelona, España. cbarrotfeixat@ub.edu
authors.forename: Carme
authors.initials: C
authors.lastname: Barrot
authors.forename: Cristina
authors.initials: C
authors.lastname: Sánchez
authors.forename: Rosa
authors.initials: R
authors.lastname: Abellana
authors.forename: Montserrat
authors.initials: M
authors.lastname: Ortega
authors.forename: Manuel
authors.initials: M
authors.lastname: Gené
mesh_terms: D000328:Adult; D017668:Age of Onset; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics; D017450:Receptors, Opioid, mu / Q000235:genetics; D012907:Smoking / Q000453:epidemiology / Q000235:genetics*; D016540:Smoking Cessation; D013030:Spain / Q000453:epidemiology; D014029:Tobacco Use Disorder / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D017211:Treatment Failure; D014365:Tryptophan Hydroxylase / Q000235:genetics / Q000502:physiology*
chemical_list: C547768:ADRA2A protein, human; C470302:HTR1B protein, human; D018377:Neurotransmitter Agents; C485764:OPRM1 protein, human; D044302:Receptor, Serotonin, 5-HT1B; D018341:Receptors, Adrenergic, alpha-2; D017450:Receptors, Opioid, mu; C497467:TPH1 protein, human; D014365:Tryptophan Hydroxylase