title: Microarray evaluation of gene expression profiles in inflamed and healthy human dental pulp: the role of IL1beta and CD40 in pulp inflammation.
abstract: Dental pulp undergoes a number of changes passing from healthy status to inflammation due to deep decay. These changes are regulated by several genes resulting differently expressed in inflamed and healthy dental pulp, and the knowledge of the processes underlying this differential expression is of great relevance in the identification of the pathogenesis of the disease. In this study, the gene expression profile of inflamed and healthy dental pulps were compared by microarray analysis, and data obtained were analyzed by Ingenuity Pathway Analysis (IPA) software. This analysis allows to focus on a variety of genes, typically expressed in inflamed tissues. The comparison analysis showed an increased expression of several genes in inflamed pulp, among which IL1&#946; and CD40 resulted of particular interest. These results indicate that gene expression profile of human dental pulp in different physiological and pathological conditions may become an useful tool for improving our knowledge about processes regulating pulp inflammation.
authors.affiliation: Department of Medical, Oral and Biotecnological Sciences, G. d' Annunzio University, Chieti-Pescara, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Gatta
authors.forename: V L
authors.initials: VL
authors.lastname: Zizzari
authors.forename: V
authors.initials: V
authors.lastname: Dd ' Amico
authors.forename: L
authors.initials: L
authors.lastname: Salini
authors.forename: M
authors.initials: M
authors.lastname: D' Aurora
authors.forename: S
authors.initials: S
authors.lastname: Franchi
authors.forename: I
authors.initials: I
authors.lastname: Antonucci
authors.forename: M T
authors.initials: MT
authors.lastname: Sberna
authors.forename: E
authors.initials: E
authors.lastname: Gherlone
authors.forename: L
authors.initials: L
authors.lastname: Stuppia
authors.forename: S
authors.initials: S
authors.lastname: Tetè
mesh_terms: D000328:Adult; D019013:CD40 Antigens / Q000235:genetics / Q000502:physiology*; D003782:Dental Pulp / Q000378:metabolism*; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D011671:Pulpitis / Q000209:etiology / Q000378:metabolism*; D059467:Transcriptome
chemical_list: D019013:CD40 Antigens; D053583:Interleukin-1beta