title: [Surgery added with fluconazole in treatment of fungal rhinosinusitis].
abstract: OBJECTIVE
  To explore the effect of surgery added with antifungal agents in treatment of fungal rhinosinusitis.
  
  
  METHODS
  One hundred and two consecutive patients with fungal rhinosinusitis were randomly divided into two groups: the control group (n=48) were treated with surgery alone, the treatment group (n=54) were treated with surgery plus antifungal therapy during operation and postoperation. The patients were followed up for 6 months and the relapse rates between two groups were compared.
  
  
  RESULTS
  No relapse was observed in the treatment group. The relapse rate of the control group was 20.8% (P < 0.01).
  
  
  CONCLUSIONS
  Surgery plus antifungal therapy can prevent the relapse of fungal rhinosinusitis significantly.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, China. zhangjian115123@hotmail.com
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Wugen
authors.initials: W
authors.lastname: Luo
authors.forename: Hongqun
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole