title: Effects of antipsychotics on dentate gyrus stem cell proliferation and survival in animal models: a critical update.
abstract: Schizophrenia is a complex psychiatric disorder. Although a number of different hypotheses have been developed to explain its aetiopathogenesis, we are far from understanding it. There is clinical and experimental evidence indicating that neurodevelopmental factors play a major role. Disturbances in neurodevelopment might result in alterations of neuroanatomy and neurochemistry, leading to the typical symptoms observed in schizophrenia. The present paper will critically address the neurodevelopmental models underlying schizophrenia by discussing the effects of typical and atypical antipsychotics in animal models. We will specifically discuss the vitamin D deficiency model, the poly I:C model, the ketamine model, and the postnatal ventral hippocampal lesion model, all of which reflect core neurodevelopmental issues underlying schizophrenia onset.
authors.affiliation: Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany. gerburg.keilhoff@med.ovgu.de
authors.forename: Gerburg
authors.initials: G
authors.lastname: Keilhoff
authors.forename: Paolo
authors.initials: P
authors.lastname: Fusar-Poli
authors.forename: Axel
authors.initials: A
authors.lastname: Becker
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D018891:Dentate Gyrus / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology* / Q000187:drug effects*; D012559:Schizophrenia / Q000209:etiology / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents