title: Cancer metabolism: what we can learn from proteomic analysis by mass spectrometry.
abstract: A variety of genomic and proteomic tools have been used to study cancer metabolism and metabolomics in order to understand how cancer cells survive in their environment. Throughout the past decade, mass spectrometry has been routinely used for large-scale protein identification of complex biological mixtures. In this review, we discuss some recent developments in cancer metabolism by proteomic analysis using mass spectrometric techniques, focusing on pyruvate kinase, L-lactate dehydrogenase, Warburg effect, glutamine metabolism and oxidative stress.
authors.affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Blvd, MS 1A9, Manassas, VA 20110, USA. wzhou@gmu.edu
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhou
authors.forename: Lance A
authors.initials: LA
authors.lastname: Liotta
authors.forename: Emanuel F
authors.initials: EF
authors.lastname: Petricoin
mesh_terms: D004734:Energy Metabolism; D005973:Glutamine / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D013058:Mass Spectrometry; D055432:Metabolomics / Q000379:methods*; D009369:Neoplasms / Q000378:metabolism*; D018384:Oxidative Stress; D040901:Proteomics / Q000379:methods*; D011770:Pyruvate Kinase / Q000378:metabolism; D017382:Reactive Oxygen Species
chemical_list: D017382:Reactive Oxygen Species; D005973:Glutamine; D019344:Lactic Acid; D007770:L-Lactate Dehydrogenase; D011770:Pyruvate Kinase