title: Descriptive analysis of molecular subtypes in Tunisian breast cancer.
abstract: OBJECTIVE
  The objective is to report the correlation between pathology and molecular subtype classifications of breast cancer in Tunisian women.
  
  
  METHODS
  This retrospective study concerned data of 966 breast cancer cases collected from 2007 to 2009 at Salah Azaiz Institute of Tunis. These cases were classified by an immunohistochemistry test for estrogen and progesterone receptors and human epidermal growth factor receptor 2 (HER2) status in the four molecular subtypes, namely luminal A, luminal B, HER2+ and triple negative. The molecular classifications were correlated with the clinicopathological characteristics of the tumors.
  
  
  RESULTS
  Luminal A (50.7% of cases) was the most common subtype, with triple negative subtype 22.5%, luminal B 13.4% and HER2+ 13.4%. Triple negative and HER2+ subtypes were significantly associated with large tumor size (>5 cm, P < 0.001), younger age (<40 years, P < 0.03) and high grade (P < 0.001). Conversely, there was no correlation with the lymph node status.
  
  
  CONCLUSIONS
  Our data demonstrated that the luminal A subtype, associated with a favorable prognosis, was the most frequent subtype in the Tunisian population; however the triple negative subtype occurred at a high incidence in Tunisia compared to Western countries. The molecular subtypes are correlated to the tumor size, histological grade and patient's age.
authors.affiliation: Department of Immunohistocytology, Institut Salah Azaiz; Research Unit no. 01/UR/08-07, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: Asma
authors.initials: A
authors.lastname: Fourati
authors.forename: Hamouda
authors.initials: H
authors.lastname: Boussen
authors.forename: Michéle V
authors.initials: MV
authors.lastname: El May
authors.forename: Aida
authors.initials: A
authors.lastname: Goucha
authors.forename: Bouthaina
authors.initials: B
authors.lastname: Dabbabi
authors.forename: Amor
authors.initials: A
authors.lastname: Gamoudi
authors.forename: Rachida
authors.initials: R
authors.lastname: Sfar
authors.forename: Khaled
authors.initials: K
authors.lastname: Rahal
authors.forename: Ahmed
authors.initials: A
authors.lastname: El May
authors.forename: Mansour
authors.initials: M
authors.lastname: Ben Abdallah
mesh_terms: D000367:Age Factors; D001943:Breast Neoplasms / Q000145:classification* / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012189:Retrospective Studies; D064726:Triple Negative Breast Neoplasms / Q000145:classification* / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology; D014416:Tunisia / Q000453:epidemiology
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human