title: Hibiscus sabdariffa Linnaeus aqueous extracts attenuate the progression of renal injury in 5/6 nephrectomy rats.
abstract: Hibiscus sabdariffa Linn. (HS) is a tropical wild plant with antioxidant, antibacterial, antihypertensive, and lipid-lowering properties. In several animal models, HS aqueous extracts reduced the severity of the multi-organ injuries such as hypertension and diabetic nephropathy. One of the multiorgan injuries is chronic kidney disease (CKD), which results from the loss of nephron function. HS was used in a 5/6 nephrectomy (5/6 Nx) rat model to determine if it could attenuate the progression of CKD. HS (250 mg/kg/day) or placebo was orally administered to 5/6 Nx male Sprague-Dawley rats. The Nx+HS group had fewer renal injuries as measured by blood urea nitrogen, serum creatinine, creatinine clearance, and renal pathology when compared with the Nx group. In order to determine which property of HS, either vasodilatory and/or antioxidant, was important in attenuating the progression of CKD, systolic blood pressure (SBP) and serum levels of malondialdehyde (MDA) were assessed. In the Nx+HS group, the SBP and the serum levels of MDA were significantly lower at Week 7. In conclusion, through either antihypertensive and/or antioxidant properties, HS was able to attenuate the progression of renal injury after 5/6 Nx. Hence, HS should be considered as one of the new, promising drugs that can be used to attenuate the progression of CKD.
authors.affiliation: Faculty of Allied Health Science, Burapha University, Chonburi, Thailand.
authors.forename: Yuyen
authors.initials: Y
authors.lastname: Seujange
authors.forename: Asada
authors.initials: A
authors.lastname: Leelahavanichkul
authors.forename: Waranurin
authors.initials: W
authors.lastname: Yisarakun
authors.forename: Witoon
authors.initials: W
authors.lastname: Khawsuk
authors.forename: Ardool
authors.initials: A
authors.lastname: Meepool
authors.forename: Ponlapat
authors.initials: P
authors.lastname: Phamonleatmongkol
authors.forename: Walai
authors.initials: W
authors.lastname: Saechau
authors.forename: Winita
authors.initials: W
authors.lastname: Onlamul
authors.forename: Pansa
authors.initials: P
authors.lastname: Tantiwarattanatikul
authors.forename: Worapong
authors.initials: W
authors.lastname: Oonsook
authors.forename: Somchai
authors.initials: S
authors.lastname: Eiam-Ong
authors.forename: Somchit
authors.initials: S
authors.lastname: Eiam-Ong
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D005500:Follow-Up Studies; D031584:Hibiscus; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects* / Q000379:methods; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy / Q000379:methods*; D028321:Plant Preparations / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
chemical_list: D028321:Plant Preparations