title: Poly(acrylic acid) modified lanthanide-doped GdVO4 hollow spheres for up-conversion cell imaging, MRI and pH-dependent drug release.
abstract: In this study, multifunctional poly(acrylic acid) modified lanthanide-doped GdVO(4) nanocomposites [PAA@GdVO(4): Ln(3+) (Ln = Yb/Er, Yb/Ho, Yb/Tm)] were constructed by filling PAA hydrogel into GdVO(4) hollow spheres via photoinduced polymerization. The up-conversion (UC) emission colors (green, red and blue) can be tuned by changing the codopant compositions in the matrices. The composites have potential applications as bio-probes for cell imaging. Meanwhile, the hybrid spheres can act as T(1) contrast agents for magnetic resonance imaging (MRI) owing to the existence of Gd(3+) ions on the surface of composites. Due to the nature of PAA, DOX-loaded PAA@GdVO(4):Yb(3+)/Er(3+) system exhibits pH-dependent drug releasing kinetics. A lower pH offers a faster drug release rate. Such character makes the loaded DOX easily released at cancer cells. The cell uptake process of drug-loaded composites was observed by using confocal laser scanning microscopy (CLSM). The results indicate the potential application of the multifunctional composites as theragnostics (effective bimodal imaging probes and pH-responsive drug carriers).
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Kang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yang
authors.forename: Yunlu
authors.initials: Y
authors.lastname: Dai
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Shang
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.forename: Hongzhou
authors.initials: H
authors.lastname: Lian
authors.forename: Ping'an
authors.initials: P
authors.lastname: Ma
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects*; D058948:Cell Tracking / Q000379:methods; D003287:Contrast Media / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008422:Materials Testing; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry; D016062:Porosity; D017968:Vanadium Compounds / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D000903:Antibiotics, Antineoplastic; D003287:Contrast Media; D028581:Lanthanoid Series Elements; D053769:Nanocapsules; D017968:Vanadium Compounds; C006903:carbopol 940; D004317:Doxorubicin; D005682:Gadolinium; C066075:vanadium pentoxide