title: Rhodium-catalyzed cysteine modification with diazo reagents.
abstract: A simple rhodium(II) complex catalyzes cysteine modification with diazo reagents. The reaction is marked by clean cysteine selectivity and mild reaction conditions. The resulting linkage is significantly more stable in human plasma serum, when compared to common maleimide reagents.
authors.affiliation: Department of Chemistry, MS 60, Rice University, 6100 Main Street, Houston, TX - 77005, USA.
authors.forename: Rituparna
authors.initials: R
authors.lastname: Kundu
authors.forename: Zachary T
authors.initials: ZT
authors.lastname: Ball
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D003545:Cysteine / Q000737:chemistry*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008301:Maleimides / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D056831:Coordination Complexes; D008301:Maleimides; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; C043592:maleimide; D012238:Rhodium; D003545:Cysteine