title: Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.
abstract: Five new phenoxazine-based alkaloids venezuelines A-E (1-5) and two new aminophenols venezuelines F-G (6-7), as well as three known analogues exfoliazone, chandrananimycin D and carboxyexfoliazone were isolated from the fermentation broth of the marine-derived bacterium Streptomyces venezuelae. The structures of new compounds were determined on the basis of extensive spectroscopic analysis. The cytotoxic activity of these compounds against a panel of tumor cell lines were tested, while the regulation of gene target Nur77 of 2 and exfoliazone (8) were evaluated.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
authors.forename: Jinwei
authors.initials: J
authors.lastname: Ren
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Yangye
authors.initials: Y
authors.lastname: Wei
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
authors.forename: Jinzhang
authors.initials: J
authors.lastname: Zeng
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000627:Aminophenols / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1 / Q000235:genetics / Q000378:metabolism*; D010078:Oxazines / Q000737:chemistry*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000627:Aminophenols; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D010078:Oxazines; C039203:phenoxazine