title: Evaluation of chronic ischemic heart disease with myocardial perfusion and regional contraction analysis by contrast-enhanced 256-MSCT.
abstract: OBJECTIVE
  To investigate myocardial viability in chronic ischemic heart disease by myocardial perfusion and regional contraction analysis using 256-slice MSCT coronary angiography (CCTA).
  
  
  METHODS
  In 30 patients with prior myocardial infarction (MI), CCTA with retrospective ECG-gating and stress-redistribution thallium-201 SPECT were performed. Using the same raw data as used for CCTA, myocardial perfusion imaging (CT-MPI) was reconstructed at four phases during the cardiac cycle. Mean myocardial attenuation and wall thickness at end-systole and end-diastole were measured in the MI areas depicted by SPECT, and they were compared between viable and non-viable segments categorized by SPECT.
  
  
  RESULTS
  End-systolic thickness was significantly greater for viable than for non-viable segments (12.0 ± 3.2 vs. 9.6 ± 3.5 mm, p = 0.0017). There was no difference in end-diastolic thickness. Myocardial attenuation was significantly higher for viable than for non-viable segments in the subendocardium (62 ± 13 vs. 70 ± 11 HU, p = 0.003) and the epicardium (65 ± 13 vs. 80 ± 15 HU, p = 0.0002).
  
  
  CONCLUSIONS
  The systolic wall thinning and epicardial low-attenuation areas were the indicative findings of CT-MPI for non-viable segments in the prior MI.
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Ko
authors.initials: K
authors.lastname: Higuchi
authors.forename: Michinobu
authors.initials: M
authors.lastname: Nagao
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamitani
authors.forename: Masato
authors.initials: M
authors.lastname: Yonezawa
authors.forename: Mikako
authors.initials: M
authors.lastname: Jinnouchi
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Koichiro
authors.initials: K
authors.lastname: Abe
authors.forename: Shingo
authors.initials: S
authors.lastname: Baba
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Mukai
authors.forename: Taiki
authors.initials: T
authors.lastname: Higo
authors.forename: Kenji
authors.initials: K
authors.lastname: Sunagawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007479:Iopamidol; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000175:diagnosis*; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods; D015203:Reproducibility of Results; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007479:Iopamidol