title: NICE clinical guideline (CG152): the management of Crohn's disease in adults, children and young people.
abstract: BACKGROUND
  The guideline offers best practice advice on the care of adults, children and young people with Crohn's disease.
  
  
  OBJECTIVE
  To provide clinically effective and cost-effective evidence-based recommendations to guide clinical practice in a clinical guideline commissioned by the National Institute for Health and Clinical Excellence (NICE).
  
  
  METHODS
  A systematic review of the evidence including critical appraisal, meta-analysis and cost-effectiveness modelling.
  
  
  RESULTS
  Thirty-one evidence-based recommendations covering induction and maintenance therapy are available. Five key priorities for implementation are identified together with nine future research recommendations. Three guideline versions are available: short (containing just the recommendations), full (containing the full evidence base) and an Understanding NICE guidance for patients and carers. Algorithms have been produced together with a NICE pathway and implementation tools.
  
  
  CONCLUSIONS
  These are the first evidence-based clinical and cost-effectiveness guidelines for Crohn's disease in the United Kingdom.
authors.affiliation: Department of Digestive Diseases, University Hospitals of Leicester NHS Trust, Leicester, UK. johnfmayberry@yahoo.co.uk
authors.forename: J F
authors.initials: JF
authors.lastname: Mayberry
authors.forename: A
authors.initials: A
authors.lastname: Lobo
authors.forename: A C
authors.initials: AC
authors.lastname: Ford
authors.forename: A
authors.initials: A
authors.lastname: Thomas
mesh_terms: D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D003362:Cost-Benefit Analysis; D003424:Crohn Disease / Q000188:drug therapy* / Q000191:economics / Q000601:surgery*; D019468:Disease Management; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D015122:Mercaptopurine / Q000627:therapeutic use; D011247:Pregnancy; D013222:State Medicine / Q000592:standards*; D006113:United Kingdom; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D015122:Mercaptopurine; D001379:Azathioprine