title: [Recombinational repair in Schizosaccharomyces pombe: the role of mediator proteins].
abstract: Repair of double-stranded DNA breaks that occur spontaneously or under the influence of external factors, are critical for cell survival. Evolutionarily conserved mechanism for error-free recombinational repair plays a major role in maintaining genome integrity. Repair pathway is conservative and has a number of similarities in lower eukaryotes and vertebrates. This review examines the current state of studying the mechanism of recombinational repair double-stranded DNA breaks in the fission yeast Schizosaccharomyces pombe, notes the differences of this type of repair in Saccharomyces cerevisiae and higher eukaryotes.
authors.forename: O S
authors.initials: OS
authors.lastname: Khasanova
authors.forename: D A
authors.initials: DA
authors.lastname: Vagin
authors.forename: F K
authors.initials: FK
authors.lastname: Khasanov
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002470:Cell Survival / Q000235:genetics; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D006801:Humans; D025941:Protein Interaction Mapping; D059767:Recombinational DNA Repair / Q000235:genetics*; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D029702:Schizosaccharomyces pombe Proteins; D004247:DNA