title: Mild and general conditions for negishi cross-coupling enabled by the use of palladacycle precatalysts.
abstract: A wide range of biaryls were synthesized by palladium-catalyzed Negishi cross-couplings at ambient temperature or with low catalyst loading. This protocol features the use of a recently reported aminobiphenyl palladacycle precatalyst to generate the catalytically active XPhosPd(0) species. Significantly, a wide range of challenging heterocyclic and polyfluorinated aromatic substrates can be employed to give products in excellent yields.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, 02139, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Oldenhuis
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D010165:Palladium