title: Cells of origin for cancer: an updated view from prostate cancer.
abstract: The cells of origin for cancer are the cells within tissues that serve as the target for transformation. Understanding the nature of these cells will benefit disease prevention, diagnosis and prognosis. During the past decade, much progress has been made in understanding the cellular origin for prostate cancer. This review aims to summarize the previous findings, describe the most recent results and discuss some controversies and unresolved issues in this field.
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. xin@bcm.edu
authors.forename: L
authors.initials: L
authors.lastname: Xin
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic; D004847:Epithelial Cells / Q000473:pathology; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D051059:PTEN Phosphohydrolase / Q000502:physiology; D011471:Prostatic Neoplasms / Q000473:pathology*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D018398:Homeodomain Proteins; C491178:NKX3-1 protein, human; D014157:Transcription Factors; D051059:PTEN Phosphohydrolase