title: Synthesis and antiproliferative activity of ammonium and imidazolium ionic liquids against T98G brain cancer cells.
abstract: Four ammonium and imidazolium ionic liquids (ILs) have been synthesized and screened against the T98G cell line (brain cancer) and HEK normal cells. Treatment induced metabolic cell death (MTT), growth inhibition, clonogenic inhibition were studied as cellular response parameters. Treatment with ILs enhanced growth inhibition and cell death in a concentration dependent manner in both the T98G and HEK cell lines. At higher concentrations (&gt;0.09 mg/mL) the cytotoxic effects of the ILs were highly significant. An inhibitory effect on clonogenic capacity was also observed after cell treatment. Amongst all ILs; IL 4 (BMIMCl) exhibited potent activity against T98G brain cancer cells. Despite potent in-vitro activity, all ILs exhibited less cytotoxicity against the normal human HEK cells at all effective concentrations.
authors.affiliation: Plasma Bioscience Research Center, Kwangwoon University, Seoul 139701, Korea. kaushik.nagendra@kw.ac.kr
authors.forename: Nagendra Kumar
authors.initials: NK
authors.lastname: Kaushik
authors.forename: Pankaj
authors.initials: P
authors.lastname: Attri
authors.forename: Neha
authors.initials: N
authors.lastname: Kaushik
authors.forename: Eun Ha
authors.initials: EH
authors.lastname: Choi
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D057809:HEK293 Cells; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D052578:Ionic Liquids / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D007093:Imidazoles; D052578:Ionic Liquids; D000644:Quaternary Ammonium Compounds; C029899:imidazole