title: Migraine and restless legs syndrome in men.
abstract: BACKGROUND
  Previous studies suggest an association between migraine and restless legs syndrome (RLS). Population-based data, however, have been limited to women. The aim of this study is to evaluate the association between migraine and RLS in a male cohort.
  
  
  METHODS
  We conducted a cross-sectional study among 22,926 participants in the Physicians' Health Study. Migraine and RLS information was self-reported. RLS was classified according to four minimal diagnostic criteria. Age- and multivariable-adjusted logistic regression models were calculated.
  
  
  RESULTS
  Of the 22,926 participants (mean age 67.8), 2816 (12.3%) reported migraine and 1717 (7.5%) RLS. Migraine was associated with an increased multivariable-adjusted odds ratio (OR) (95% confidence interval (CI)) of 1.20 (1.04-1.38) for having RLS. The association remained stable after excluding men with potential mimics of RLS and was not modified by age.
  
  
  CONCLUSIONS
  Results of our study indicate an association between migraine and RLS in men. The magnitude of effect is similar to what has been reported in women.
authors.affiliation: Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, USA.
authors.forename: Anke C
authors.initials: AC
authors.lastname: Winter
authors.forename: Markus
authors.initials: M
authors.lastname: Schürks
authors.forename: Klaus
authors.initials: K
authors.lastname: Berger
authors.forename: Julie E
authors.initials: JE
authors.lastname: Buring
authors.forename: J Michael
authors.initials: JM
authors.lastname: Gaziano
authors.forename: Tobias
authors.initials: T
authors.lastname: Kurth
mesh_terms: D000368:Aged; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D054526:Men's Health / Q000706:statistics & numerical data*; D008881:Migraine Disorders / Q000453:epidemiology*; D012148:Restless Legs Syndrome / Q000453:epidemiology*; D012307:Risk Factors; D012737:Sex Factors