title: Combination of Aβ clearance and neurotrophic factors as a potential treatment for Alzheimer's disease.
abstract: There is no effective drug to treat Alzheimer's disease (AD), a neurodegenerative disease affecting an estimated 30 million people around the world. Strongly supported by preclinical and clinical studies, amyloid-beta (Aβ) may be a target for developing drugs against AD. Meanwhile, the fact that localized neuronal death/loss and synaptic impairment occur in AD should also be considered. Neuronal regeneration, which does not occur normally in the mammalian central nervous system, can be promoted by neurotrophic factors (NTFs). Evidence from clinical trials has shown that both Aβ clearance and NTFs are potentially effective in treating AD, thus a new approach combining Aβ clearance and administration of NTFs may be an effective therapeutic strategy.
authors.affiliation: Department of Pharmacology, Jinan University, Guangzhou, 510632, China.
authors.forename: Lian-Feng
authors.initials: LF
authors.lastname: Lin
authors.forename: Min-Jing
authors.initials: MJ
authors.lastname: Liao
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Xue
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Liang
authors.initials: L
authors.lastname: Cai
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Zhou
authors.forename: Xing
authors.initials: X
authors.lastname: Zhou
authors.forename: Huan-Min
authors.initials: HM
authors.lastname: Luo
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008657:Metabolic Clearance Rate / Q000502:physiology; D009414:Nerve Growth Factors / Q000627:therapeutic use*
chemical_list: D016229:Amyloid beta-Peptides; D009414:Nerve Growth Factors