title: Recent advances in the combination of capillary electrophoresis with mass spectrometry: from element to single-cell analysis.
abstract: This overview deals with the latest development of electrophoresis in capillaries and microfluidic devices coupled to MS detection. A wide selection of relevant articles covers the literature published from January 2010 till June 2012 as a continuation of the review article on the same topic by Pantuckova et al. [Electrophoresis 2011, 32, 43-51]. Special attention is paid to the new improvements in instrumentation and methodology of three interfacing methods, ESI, matrix-assisted desorption/ionization, and ICP. Representative examples illustrate applications in the proteomics, glycomics, metabolomics, biomarker research, forensics, pharmacology, food analysis and single-cell analysis. The combinations of MS with capillary versions of electrochromatography, ITP, IEF, and micellar electrokinetic chromatography are not included.
authors.affiliation: Institute of Analytical Chemistry, Academy of Sciences of the Czech Republic, Brno, Czech Republic. klep@iach.cz
authors.forename: Karel
authors.initials: K
authors.lastname: Klepárník
mesh_terms: D015415:Biomarkers / Q000032:analysis; D004340:Drug Contamination; D019075:Electrophoresis, Capillary / Q000379:methods* / Q000639:trends; D005504:Food Analysis / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation; D040901:Proteomics / Q000379:methods; D059010:Single-Cell Analysis / Q000379:methods; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods
chemical_list: D015415:Biomarkers