title: [Systemic endotoxinemia as a pathogenetic factor of pregnancy complication].
abstract: OBJECTIVE
  Evaluation of the role of hemocirculation of a bacterial endotoxin in pregnancy complicated with gestosis.
  
  
  METHODS
  A complex clinical-laboratory examination of 74 pregnant women at the II-III trimester of gestational period including determination of serum cytokine levels (TNFalpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IFNgamma), C-reactive protein, LPS, LPS-binding protein and IgG against R-core LPS in blood plasma was performed.
  
  
  RESULTS
  In pregnant women with gestosis an increase in endotoxinemia level (p < 0.0001), twofold increase in IgG titers against R-core LPS (p < 0.01) and an increase in LBP concentration by 14% (p < 0.05) without an increase in concentration of C-reactive protein were shown. Cytokine profile in gestosis was characterized by a twofold statistically significant increase of IL-1beta (p < 0.0001), IL-8 (p < 0.0001) pro-inflammatory cytokine levels, a tendency of IL-6 (p = 0.063), TNFalpha (p = 0.13) increase and a decrease of Th1 cytokine concentrations: IL-2 - by 6.5 times (p < 0.0001), IFNgamma--by 2 times (p < 0.0001).
  
  
  CONCLUSIONS
  The results allow to consider gestoses as a manifestation of increased endotoxin translocation into systemic blood flow during gestation, that determines the necessity to improve therapeutic measures in this pathology.
authors.forename: A R
authors.initials: AR
authors.lastname: Mavziutov
authors.forename: K R
authors.initials: KR
authors.lastname: Bondarenko
authors.forename: A N
authors.initials: AN
authors.lastname: Enikeev
authors.forename: V M
authors.initials: VM
authors.lastname: Bondarenko
mesh_terms: D000209:Acute-Phase Proteins / Q000276:immunology; D000328:Adult; D001419:Bacteria / Q000276:immunology / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000097:blood / Q000276:immunology / Q000382:microbiology*; D002097:C-Reactive Protein / Q000032:analysis / Q000276:immunology; D002352:Carrier Proteins / Q000097:blood / Q000276:immunology; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D008070:Lipopolysaccharides / Q000097:blood* / Q000276:immunology; D008562:Membrane Glycoproteins / Q000097:blood / Q000276:immunology; D011225:Pre-Eclampsia / Q000097:blood / Q000276:immunology / Q000382:microbiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000276:immunology / Q000382:microbiology*; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012720:Severity of Illness Index; D058408:Th1-Th2 Balance; D000099231:Lipopolysaccharide-Binding Protein
chemical_list: D000209:Acute-Phase Proteins; D002097:C-Reactive Protein; D002352:Carrier Proteins; D016207:Cytokines; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein