title: [Effective multidisciplinary therapy mainly using S-1+ gemcitabine (GEM) for a case of pancreatic body cancer with multiple liver metastases].
abstract: The prognosis for pancreatic cancer with distant metastasis is not good. The case reported here concerns a pancreatic body cancer with multiple liver metastases for which multidisciplinary therapy of S-1+gemcitabine(GEM)therapy, surgery, and radiofrequency ablation proved to be effective, resulting in complete remission. The patient was a 77-year-old female. She was asymptomatic and diagnosed with pancreatic body cancer with multiple liver metastasis at the end of December 2008 by ultrasonography. After careful examination, GEM 1, 200mg/body was administered on days 1 and 15, and S-1 was administered orally at 80mg/day for two weeks, followed by two weeks of rest. By the end of the 15th course, the size of the tumor had reduced from 26. 5mm to 14. 4mm, and all but one of the liver lesions disappeared; the remaining one lesion was measured as 14. 5mm by ultrasonography. We performed pancreas body and tail resection and radiofrequency therapy for the remaining single liver metastasis. After operation, GEM was administered once a month for 4 months. S-1 was not administered, but a new lesion was revealed at the S8 area by ultrasonography. We restarted S-1+GEM therapy and in 5 months the new lesion disappeared from image examinations. She is alive and in complete remission 16 months after the operation.
authors.affiliation: Dept. of Surgery, Matsumoto Hospital.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Fukui
authors.forename: Chison
authors.initials: C
authors.lastname: Kou
authors.forename: Masayuki
authors.initials: M
authors.lastname: Fujioka
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D010094:Oxonic Acid / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012074:Remission Induction; D005641:Tegafur / Q000008:administration & dosage; D000093542:Gemcitabine
chemical_list: D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000093542:Gemcitabine