title: [Mast cell inhibitory receptors].
abstract: Mast cells play an important role in diverse physiological mechanisms as well as taking part in antimicrobial defense. What is more, these cells are important regulators of a number of pathophysiological processes, involving allergic reactions. Therefore, it seems to be very important to know and understand the factors and receptors influencing mast cell activity. Nowadays it is well established that activating signals are counterbalanced by negative or inhibition signals transmitted by inhibitory receptors containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Inhibitory receptor engagement leads to ITIM tyrosine phosphorylation, the recruitment and activation of protein tyrosine phosphatases such as SHP-1, SHP-2 and/or SHIP, and the dephosphorylation of activating receptor associated proteins. There is growing evidence that a number of inhibitory receptors have been identified on mast cells. The scope of this paper is to present the current knowledge on mast cell-associated inhibitory receptors, such as FcγRIIB, paired immunoglobulin-like receptor B (PIR-B), CD300, CD172a, gp49B1, CD200R, sialic acid-binding immunoglobulin-like lectin (Siglec) molecules, CD305, allergin-1, mast cell function-associated antigen (MAFA), and CD72. The role of these inhibitory receptors in regulation mast cell activity is also discussed.
authors.affiliation: Zakład Immunologii Doświadczalnej, Uniwersytet Medyczny w Łodzi, 92-213 Łódź, Poland.
authors.forename: Edyta
authors.initials: E
authors.lastname: Bąbolewska
authors.forename: Ewa
authors.initials: E
authors.lastname: Brzezińska-Błaszczyk
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D000943:Antigens, Differentiation / Q000276:immunology; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology; D064446:Orexin Receptors; D017027:Protein Tyrosine Phosphatases / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology*; D055630:Receptors, NK Cell Lectin-Like / Q000276:immunology; D063265:Sialic Acid Binding Immunoglobulin-like Lectins / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D000944:Antigens, Differentiation, B-Lymphocyte; D000954:Antigens, Surface; C477337:CD200R1 protein, human; C515070:CD300A protein, human; C064228:CD72 protein, human; D047908:Intracellular Signaling Peptides and Proteins; C489448:Lilrb4 protein, mouse; D008562:Membrane Glycoproteins; D064446:Orexin Receptors; C404960:PILRB protein, human; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D055630:Receptors, NK Cell Lectin-Like; C501920:SIRPA protein, human; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D017027:Protein Tyrosine Phosphatases