title: Predicting the structure of cyclic lipopeptides by bioinformatics: structure revision of arthrofactin.
abstract: Arthrofactin, a bioactive cyclic lipopeptide from Pseudomonas sp. MIS38, was reinvestigated for its structural and stereochemical features due to discrepancies between the genetics-based sequence prediction and the currently suggested structure. The structure of arthrofactin and its derivatives was reassigned on the basis of chiral HPLC analysis and extensive NMR and MS experiments. Furthermore, derivatives of arthrofactin were discovered.
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Lange
authors.forename: Han
authors.initials: H
authors.lastname: Sun
authors.forename: Jens
authors.initials: J
authors.lastname: Pilger
authors.forename: Uwe M
authors.initials: UM
authors.lastname: Reinscheid
authors.forename: Harald
authors.initials: H
authors.lastname: Gross
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D019295:Computational Biology / Q000379:methods*; D055666:Lipopeptides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010802:Phylogeny
chemical_list: D001426:Bacterial Proteins; D055666:Lipopeptides; D010456:Peptides, Cyclic; C083714:arthrofactin