title: Bioinspired, releasable quorum sensing modulators.
abstract: We demonstrate the synthesis and immobilization of natural product hybrids featuring an acyl-homoserine lactone and a nitrodopamine onto biocompatible TiO(2) surfaces through an operationally simple dip-and-rinse procedure. The resulting immobilized hybrids were shown to be powerful quorum sensing (QS) activators in Pseudomonas strains acting by slow release from the surface.
authors.affiliation: Department of Chemistry, NCCR Chemical Biology, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland.
authors.forename: José
authors.initials: J
authors.lastname: Gomes
authors.forename: Alexander
authors.initials: A
authors.lastname: Grunau
authors.forename: Adrien K
authors.initials: AK
authors.lastname: Lawrence
authors.forename: Leo
authors.initials: L
authors.lastname: Eberl
authors.forename: Karl
authors.initials: K
authors.lastname: Gademann
mesh_terms: D054742:Acyl-Butyrolactones / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D004298:Dopamine / Q000737:chemistry*; D011549:Pseudomonas / Q000502:physiology; D053038:Quorum Sensing; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D054742:Acyl-Butyrolactones; D001672:Biocompatible Materials; C009495:titanium dioxide; D014025:Titanium; D004298:Dopamine