title: Latent inhibition in an insect: the role of aminergic signaling.
abstract: Latent inhibition (LI) is a decrement in learning performance that results from the nonreinforced pre-exposure of the to-be-conditioned stimulus, in both vertebrates and invertebrates. In vertebrates, LI development involves dopamine and serotonin; in invertebrates there is yet no information. We studied differential olfactory conditioning of the proboscis extension response in the honeybee Apis mellifera, and we compared LI in individuals treated with antagonists of biogenic amines (dopamine, octopamine, and serotonin). An antagonist of octopamine receptors and two antagonists of serotonin receptors showed LI disruption. We thus provide evidence that serotonin would participate in the regulation of LI in honeybees.
authors.affiliation: Departamento de Biodiversidad y Biología Experimental, Grupo de Estudio de Insectos Sociales, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria 1428, Buenos Aires, Argentina.
authors.forename: Vanesa M
authors.initials: VM
authors.lastname: Fernández
authors.forename: Martin
authors.initials: M
authors.lastname: Giurfa
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Devaud
authors.forename: Walter M
authors.initials: WM
authors.lastname: Farina
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001516:Bees / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D003984:Dibenzazepines / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism* / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D016314:Ethylketocyclazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology*; D005476:Fluphenazine / Q000494:pharmacology; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D007266:Inhibition, Psychological; D007650:Ketanserin / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D009812:Odorants; D012701:Serotonin / Q000378:metabolism* / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D012903:Smell / Q000187:drug effects / Q000502:physiology
chemical_list: D003984:Dibenzazepines; D018492:Dopamine Antagonists; D006634:Histamine H1 Antagonists; D007093:Imidazoles; D012702:Serotonin Antagonists; D012701:Serotonin; D016314:Ethylketocyclazocine; C012395:ketazocine; D007650:Ketanserin; C053090:epinastine; D005476:Fluphenazine; D004298:Dopamine; D008784:Methysergide