title: Methylation of the UNC5C gene is frequently detected in hepatocellular carcinoma.
abstract: OBJECTIVE
  Recently, we detected that UNC5C expression was downregulated in colon and gastric cancer.
  
  
  METHODS
  In the present study, the methylation status of the UNC5C gene was examined in primary carcinomas and the corresponding normal tissues derived from 42 patients with HCC.
  
  
  RESULTS
  Methylation of the UNC5C gene was detected in 11 out of the 42 (26%) HCCs, suggesting that the methylation of UNC5C was frequently observed in HCCs. The clinicopathological data were correlated with the methylation results.
  
  
  CONCLUSIONS
  TNM stage 1 HCC presented UNC5C methylation, indicating that the UNC5C gene has been methylated from the early stages of HCC.
authors.affiliation: Showa University, Yokohama, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Hibi
authors.forename: Kazuma
authors.initials: K
authors.lastname: Sakuraba
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shirahata
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Goto
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Saito
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Gaku
authors.initials: G
authors.lastname: Kigawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nemoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sanada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D019175:DNA Methylation; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D000075386:Netrin Receptors; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011956:Receptors, Cell Surface / Q000235:genetics*
chemical_list: D000075386:Netrin Receptors; D011956:Receptors, Cell Surface; C115727:UNC5C protein, human