title: Evaluation of Th17-related cytokines and receptors in multiple sclerosis patients under interferon β-1 therapy.
abstract: Th17-related cytokines (IL-17, IL-23, and IL-26) and receptors (IL-17R and IL-23R) were evaluated in MS patients under immunomodulatory IFN-β1 therapy during a 2year follow-up. Before the initiation of treatment, no significant difference was found in cytokine or receptor expression between controls and MS patients. Of the three cytokines evaluated, IL-26 was the highest in the patients' sera. The amount of IL-17 and CD13(+)IL-17R(+) cells was steadily decreased whereas IL-23 and IL-26 levels were gradually increased with IFN-β1 therapy. The patients in progressive phase had very high levels of IL-17. Th17-associated parameters should be considered in the immunomodulatory IFN-β1 therapy of MS.
authors.affiliation: Department of Basic Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey.
authors.forename: Gunes
authors.initials: G
authors.lastname: Esendagli
authors.forename: Asli Tuncer
authors.initials: AT
authors.lastname: Kurne
authors.forename: Guliz
authors.initials: G
authors.lastname: Sayat
authors.forename: Ahmet Kasim
authors.initials: AK
authors.lastname: Kilic
authors.forename: Dicle
authors.initials: D
authors.lastname: Guc
authors.forename: Rana
authors.initials: R
authors.lastname: Karabudak
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D020381:Interleukin-17 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000276:immunology* / Q000378:metabolism; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17; D016899:Interferon-beta