title: Chemical probes for drug-resistance assessment by binding competition (RABC): oseltamivir susceptibility evaluation.
abstract: The wizard of OS (resistance): the binding difference of neuraminidase inhibitors (zanamivir versus oseltamivir (OS)) was used to establish an assay to identify the influenza subtypes that are resistant to OS but still sensitive to zanamivir. This assay used a zanamivir-biotin conjugate to determine the OS susceptibility of a wide range of influenza viruses and over 200 clinical isolates.
authors.affiliation: The Genomics Research Center, Academia Sinica, Taipei, Taiwan.
authors.forename: Ting-Jen R
authors.initials: TJ
authors.lastname: Cheng
authors.forename: Shi-Yun
authors.initials: SY
authors.lastname: Wang
authors.forename: Wen-Hsien
authors.initials: WH
authors.lastname: Wen
authors.forename: Ching-Yao
authors.initials: CY
authors.lastname: Su
authors.forename: Mengi
authors.initials: M
authors.lastname: Lin
authors.forename: Wen-I
authors.initials: WI
authors.lastname: Huang
authors.forename: Ming-Tsan
authors.initials: MT
authors.lastname: Liu
authors.forename: Ho-Sheng
authors.initials: HS
authors.lastname: Wu
authors.forename: Nung-Sen
authors.initials: NS
authors.lastname: Wang
authors.forename: Chung-Kai
authors.initials: CK
authors.lastname: Cheng
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Chen
authors.forename: Chien-Tai
authors.initials: CT
authors.lastname: Ren
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Wu
authors.forename: Jim-Min
authors.initials: JM
authors.lastname: Fang
authors.forename: Yih-Shyun E
authors.initials: YS
authors.lastname: Cheng
authors.forename: Chi-Huey
authors.initials: CH
authors.lastname: Wong
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D001667:Binding, Competitive; D024882:Drug Resistance, Viral; D006801:Humans; D057221:Influenza A Virus, H1N2 Subtype / Q000187:drug effects; D053139:Oseltamivir / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir