title: Local delivery of the hemostatic agent tranexamic acid in chronically anticoagulated patients.
abstract: In oral surgery, the management of patients on anticoagulant therapy is still challenging because of the risks of uncontrolled bleeding and, if the therapy is discontinued, the possibility of undesired thromboembolic complications. The use of local hemostatic agents may be a viable alternative to overcome these issues. Along these lines, the aim of this work was to evaluate the use of newly developed swelling matrices loaded with tranexanic acid in preventing postextractive bleeding in patients with no modification of oral anticoagulant therapy. The matrices are made up of cellulose and are able to fit the tridimensional postextractive alveolar cavity, thus assuring also a mechanical contribution to homeostasis. The potential of this new therapeutic approach in reducing hospitalization, removing the risk of infections, and lowering the number of hemorrhagic complications was demonstrated.
authors.affiliation: Department of Odontostomatologic and Maxillofacial Science, Faculty of Medicine, University of Naples Federico II, Via Pansini n-5, 80131 Naples, Italy.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Sammartino
authors.forename: Gaetano
authors.initials: G
authors.lastname: Marenzi
authors.forename: Agnese
authors.initials: A
authors.lastname: Miro
authors.forename: Francesca
authors.initials: F
authors.lastname: Ungaro
authors.forename: Antonella
authors.initials: A
authors.lastname: Nappi
authors.forename: Josè Camilla
authors.initials: JC
authors.lastname: Sammartino
authors.forename: Fabiana
authors.initials: F
authors.lastname: Quaglia
authors.forename: Carmen
authors.initials: C
authors.lastname: Mortellaro
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage; D005260:Female; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019647:Oral Surgical Procedures; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D014148:Tranexamic Acid / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; D006490:Hemostatics; D014148:Tranexamic Acid