title: [The study of risk factors of nasal septal perforation in rats].
abstract: OBJECTIVE
  To study the risk factors and interaction of nasal septal perforation (NSP) in rats.
  
  
  METHODS
  Animals (n=120) that underwent unilateral nasal obstruction using Merocel nasal packing or gelfoam with/without standard staphylococcus aureus inoculation were observed for the formation of NSP at 2, 3, 5, and 7 days after operation by endoscope system. Following sacrifice at 7 days, the obtained nasal secretions were prepared for bacterial culture. Experimental interventions were compared with normal controls (n=10).
  
  
  RESULTS
  Perforation of nasal septum was observed in 80% of the animals accepted nasal obstruction using Merocel nasal packing with standard staphylococcus aureus inoculation in 3 days (P < 0.01), while in 70% of those using abacterial Merocel nasal packing in 5 days (P < 0.05) and no significant difference than that of before (P > 0.05). There was a weak region in anteroinferior nasal septum in rats, which the almost NSPs located in. The position of NSP does not overlap Merocel.
  
  
  CONCLUSIONS
  The interaction of risk factors contributes to NSP. The occurrence of NSP mainly depends on the construction of nasal septum, while dysaemia is also necessary. Obstruction of nasal drainage and infection promote the development of NSP.
authors.affiliation: Department of Otorinolaryngology, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210028, China.
authors.forename: Chenjie
authors.initials: C
authors.lastname: Yu
authors.forename: Xinyan
authors.initials: X
authors.lastname: Cui
authors.forename: Yajun
authors.initials: Y
authors.lastname: Gu
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.forename: Guangjie
authors.initials: G
authors.lastname: Zhu
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Tongmei
authors.initials: T
authors.lastname: Li
authors.forename: Xia
authors.initials: X
authors.lastname: Gao
mesh_terms: D000818:Animals; D015984:Causality; D004195:Disease Models, Animal; D008297:Male; D015508:Nasal Obstruction / Q000382:microbiology / Q000473:pathology*; D061270:Nasal Septal Perforation / Q000209:etiology*; D009300:Nasal Septum / Q000033:anatomy & histology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000473:pathology