title: [Relation of the rs9939609 gene variant in FTO with cardiovascular risk factor and serum adipokine levels in morbid obese patients].
abstract: BACKGROUND
  Common polymorphisms of the fat mass and obesity associated gene (FTO) have been linked to obesity in some populations. The aim of our study was to analyze the relationship of the rs9939609 FTO gene polymorphism on body weight, cardiovascular risk factors and serum adipokine levels in morbid obese patients.
  
  
  METHODS
  A sample of 129 patients with obesity was analyzed in a cross sectional design. Weight, blood pressure, basal glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides blood and adipocytokines (leptin, adiponectin, resistin, TNF alpha, and interleukin 6) levels were measured. A tetrapolar bioimpedance and a prospective serial assessment of nutritional intake with 3 days written food records were realized. Genotype of FTO gene polymorphism (rs9939609) was studied.
  
  
  RESULTS
  Forty three patients (31.8%) had TT genotype, 55 patients (42.6%) TA genotype and 33 patients (25.6%) AA genotype. Body mass index (43.6 (2.6) kg/m² vs. 44.1 (2.9) kg/m²; p < 0.05), fat mass (52.0 (12.5) kg vs. 56.3 (11.7) kg: p < 0.05), weight (111.6 (16.2) kg vs. 114.9 (18.9) kg; p < 0.05), levels of C reactive protein (6.1 (4.3) mg/dl vs. 9.8 (7.1) mg/dl; p < 0.05) and levels of leptin (65.9 (52.2) ng/ml vs. 110.9 (74.1); < 0.05) were higher in mutant type group (A allele) than wild genotype group (TT).
  
  
  CONCLUSIONS
  The FTO gene polymorphism, rs9939609, was found to be associated with weight, fat mass, C reactive protein and leptin levels in morbid obese patients with A allele.
authors.affiliation: Centro de Investigación de Endocrinología y Nutrición Clínica, Facultad de Medicina, Hospital Río Ortega, Universidad de Valladolid, Valladolid, España. dadluis@yahoo.es
authors.forename: D A
authors.initials: DA
authors.lastname: de Luis
authors.forename: R
authors.initials: R
authors.lastname: Aller
authors.forename: R
authors.initials: R
authors.lastname: Conde
authors.forename: O
authors.initials: O
authors.lastname: Izaola
authors.forename: B
authors.initials: B
authors.lastname: de la Fuente
authors.forename: M
authors.initials: M
authors.lastname: González Sagrado
authors.forename: D
authors.initials: D
authors.lastname: Primo
authors.forename: M
authors.initials: M
authors.lastname: Ruiz Mambrilla
mesh_terms: D054392:Adipokines / Q000097:blood*; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D001774:Blood Chemical Analysis; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics; D003430:Cross-Sectional Studies; D004032:Diet; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D011110:Polymorphism, Genetic / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D054392:Adipokines; D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human