title: Clinicopathological characteristics of rectal carcinoid patients undergoing surgical resection.
abstract: The aim of this study was to clarify the clinical aspects, histopathological features and prognosis of patients with rectal carcinoids, focusing on properties associated with metastasis, in order to gain insights into appropriate management. A total of 20 patients (15 males, 5 females; mean age, 54.9 years; range, 23-71) who underwent surgery for rectal carcinoid tumors at the Department of Colorectal Surgery, Hyogo College of Medicine, between May 2000 and January 2011 were analyzed. Ki-67 immunostaining was performed in 13 cases with available tumor tissue specimens. Of the 20 patients, a radical operation including rectal resection with a lymphadenectomy was performed in 16. The mean tumor size was 11.9 mm (3-25 mm) and lymph node metastasis was confirmed in 9 cases, including 3 with lesions no greater than 7 mm in diameter. Overall, 16 (80%) of the tumors were localized in the submucosal layer and 4 (20%) involved the proper muscle layer. Ki-67 labeling index and lymphovascular invasion were shown to be associated with lymph node and/or distant metastasis by multiple logistic regression analysis, but were not statistically significant in ANOVA findings. Lymph node metastasis from rectal carcinoids, even those smaller than 10 mm in diameter, was not a rare event. More attention should be given to decision-making, including the possibility of endoscopic resection for the treatment of rectal carcinoid tumors regardless of size.
authors.affiliation: Division of Lower GI, Department of Surgery;
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamagishi
authors.forename: Nagahide
authors.initials: N
authors.lastname: Matsubara
authors.forename: Masafumi
authors.initials: M
authors.lastname: Noda
authors.forename: Tomoki
authors.initials: T
authors.lastname: Yamano
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tsukamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Kuno
authors.forename: Mie
authors.initials: M
authors.lastname: Hamanaka
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeuchi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Matsuda
authors.forename: Seiichi
authors.initials: S
authors.lastname: Hirota
authors.forename: Naohiro
authors.initials: N
authors.lastname: Tomita