title: The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors.
abstract: A diverse 23-compound library of N-1 substituted 2-aminobenzimidazoles was synthesized via an efficient three-step process. This small library produced several non-toxic biofilm modulators of two strains of MRSA. Preliminary mechanistic studies reveal a zinc-dependent mode of action for these compounds.
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA. ; Tel: (+1)919-513-2960.
authors.forename: Erick A
authors.initials: EA
authors.lastname: Lindsey
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Brackett
authors.forename: Trey
authors.initials: T
authors.lastname: Mullikin
authors.forename: Cristina
authors.initials: C
authors.lastname: Alcaraz
authors.forename: Christian
authors.initials: C
authors.lastname: Melander