title: Comparison of two portable lactate meters in dogs.
abstract: The objective of this study was to compare two portable lactate analyzers for testing canine patients in a clinical setting with a previously accepted methodology for measuring plasma lactate. Between Jan 1, 2005 and Jun 1, 2006, all samples were analyzed using two different portable analyzers (devices A and B), and 86 of those samples were also analyzed by a reference laboratory (REF). The concordance correlation coefficient (CCC) for device A and the REF was 0.949 (95% confidence interval [95% CI], 0.923-0.966). For device B and REF, the CCC was 0.990 (95% CI, 0.985-0.993). Only 8 of 85 samples (9.4%) exceeded a relative difference of 20% for device B (note that 1 of the 86 samples was not included because the lactate level fell below the detectable limit of device B), but 48 of 85 samples (56.5%) exceeded a relative difference of 20% for device A. Both portable lactate analyzers appeared to be effective in detecting clinically significant elevations in plasma lactate compared with the REF but device B had better agreement. A positive correlation among all three analyzers existed; however, the analyzers do not yield directly interchangeable results.
authors.affiliation: Veterinary Specialty Services, Manchester, MO, USA.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Karagiannis
authors.forename: Fred A
authors.initials: FA
authors.lastname: Mann
authors.forename: Richard W
authors.initials: RW
authors.lastname: Madsen
authors.forename: Linda M
authors.initials: LM
authors.lastname: Berent
authors.forename: Rebecca
authors.initials: R
authors.lastname: Greer
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000295:instrumentation / Q000379:methods / Q000592:standards / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood* / Q000175:diagnosis; D004285:Dogs / Q000097:blood*; D005260:Female; D000860:Hypoxia / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D007773:Lactates / Q000097:blood*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D007773:Lactates