title: Incidence and survival rates among pediatric osteogenic sarcoma cases in Khon Kaen, Thailand, 1985-2010.
abstract: BACKGROUND
  Osteosarcoma is the most common bone cancer in children, responsible for a high rate of amputation and death. This is the first long-term, population-based, epidemiologic and survival study in Thailand.
  
  
  OBJECTIVE
  To study the incidence and survival rates of pediatric osteosarcoma in Khon Kaen.
  
  
  METHODS
  Childhood osteosarcoma cases (0-19 years) diagnosed between 1985-2010 were reviewed. The data were retrieved from the population-based data set of the Khon Kaen Cancer Registry and medical records from Srinagarind Hospital, Faculty of Medicine, Khon Kaen University. All cases were censored until the end of April 2012. The age-standardized incidence rate (ASR) was calculated using the standard method. Survival experience was analyzed using the standard survival function (STATA 9.0) and presented with a Kaplan-Meier curve.
  
  
  RESULTS
  58 cases were enrolled. The overall ASR was 14.1 per million. Males and females were equally affected. The peak incidence was for 15-19 year-olds in both sexes (ASR=10.4 per million in males and 8.5 in females). The 5-year overall survival rate was 27.6% (95% CI: 15.8-40.8%). The median survival time was 1.6 years (95% CI: 1.2-2.1). In a subgroup analysis, the patients who received only chemotherapy survived longer (5-year survival 45.7%, median survival time 4.1 years, p=0.12).
  
  
  CONCLUSIONS
  The incidence rate for childhood osteosarcoma was slightly less than those reported for Western countries. The survival rate was also lower than reports from developed countries. Further evaluation of the treatment protocol and risk factor stratification is needed.
authors.affiliation: Department of Pediatrics, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Pattara
authors.initials: P
authors.lastname: Wiromrat
authors.forename: Arunee
authors.initials: A
authors.lastname: Jetsrisuparb
authors.forename: Patcharee
authors.initials: P
authors.lastname: Komvilaisak
authors.forename: Winai
authors.initials: W
authors.lastname: Sirichativapee
authors.forename: Supot
authors.initials: S
authors.lastname: Kamsa-Ard
authors.forename: Surapon
authors.initials: S
authors.lastname: Wiangnon
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000671:Amputation, Surgical; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D012516:Osteosarcoma / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D012042:Registries; D015996:Survival Rate; D013785:Thailand / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents