title: Hippocampal volume and CDR-SB can predict conversion to dementia in MCI patients.
abstract: OBJECTIVE
  To evaluate the combination of two factors: clinical dementia rating sum of boxes scores (CDR-SB) and hippocampal volume (HV) as predictors of conversion from mild cognitive impairment (MCI) to dementia.
  
  
  METHODS
  Twenty-eight individuals (9 normal and 19 with MCI) were classified according to their CDR sum of boxes scores into 3 groups.
  
  
  RESULTS
  The hippocampal volume was significantly lower in the high-risk group and in those who developed dementia after two years. The rate of conversion was crescent among the three groups.
  
  
  CONCLUSIONS
  We were proposed an additional measurement of the hippocampal volume which may be helpful in the prognosis. However, we noted that the CDR-SB is a method as efficient as neuroimaging to predict dementia with the advantage of being a procedure for low cost and easy implementation, more consistent with public policy.
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo UNIFESP, São Paulo SP, Brazil. joaoborgio@gmail.com
authors.forename: João Guilherme Fiorani
authors.initials: JG
authors.lastname: Borgio
authors.forename: Leonardo
authors.initials: L
authors.lastname: Baldaçara
authors.forename: Walter dos Santos
authors.initials: Wdos S
authors.lastname: Moraes
authors.forename: Acioly L T
authors.initials: AL
authors.lastname: Lacerda
authors.forename: Maria Beatriz
authors.initials: MB
authors.lastname: Montaño
authors.forename: Andrea Parolin
authors.initials: AP
authors.lastname: Jackowski
authors.forename: Sérgio
authors.initials: S
authors.lastname: Tufik
authors.forename: Luiz Roberto
authors.initials: LR
authors.lastname: Ramos
authors.forename: Rodrigo Affonseca
authors.initials: RA
authors.lastname: Bressan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D003704:Dementia / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D018450:Disease Progression; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018709:Statistics, Nonparametric; D014505:Urban Population