title: It does not look odd to me: perceptual impairments and eye movements in amnesic patients with medial temporal lobe damage.
abstract: Studies of people with memory impairments have shown that a specific set of brain structures in the medial temporal lobe (MTL) is vital for memory function. However, whether these structures have a role outside of memory remains contentious. Recent studies of amnesic patients with damage to two structures within the MTL, the hippocampus and the perirhinal cortex, indicated that these patients also performed poorly on perceptual tasks. More specifically, they performed worse than controls when discriminating between objects, faces and scenes with overlapping features. In order to investigate whether these perceptual deficits are reflected in their viewing strategies, we tested a group of amnesic patients with MTL damage that included the hippocampus and perirhinal cortex on a series of oddity discrimination tasks in which they had to select an odd item from a visual array. Participants' eye movements were monitored throughout the experiment. Results revealed that patients were impaired on tasks that required them to discriminate between items that shared many features, and tasks that required processing items from different viewpoints. An analysis of their eye movements revealed that they exhibited a similar viewing pattern as controls: they fixated more on the target item on trials answered correctly, but not on trials answered incorrectly. In addition, their impaired performance was not explained by an abnormal viewing-strategy that assessed their use of working memory. These results suggest that the perceptual deficits in the MTL patients are not a consequence of abnormal viewing patterns of the objects and scenes, but instead, could involve an inability to bind information gathered from several fixations into a cohesive percept. These data also support the view that MTL structures are important not only for long-term memory, but are also involved in perceptual tasks.
authors.affiliation: Department of Psychology (St. George), University of Toronto, Toronto, ON, Canada M5S 3G3. Jonathan.erez@utoronto.ca
authors.forename: Jonathan
authors.initials: J
authors.lastname: Erez
authors.forename: Andy C H
authors.initials: AC
authors.lastname: Lee
authors.forename: Morgan D
authors.initials: MD
authors.lastname: Barense
mesh_terms: D000368:Aged; D000647:Amnesia / Q000150:complications*; D001930:Brain Injuries / Q000150:complications* / Q000473:pathology*; D005145:Face; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015835:Ocular Motility Disorders / Q000209:etiology*; D010364:Pattern Recognition, Visual / Q000502:physiology; D010468:Perceptual Disorders / Q000209:etiology*; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D021641:Recognition, Psychology; D013702:Temporal Lobe / Q000473:pathology*; D013997:Time Factors