title: Won't you come on in? How to favor lymphocyte infiltration in tumors.
abstract: Abnormal tumor vasculature and endothelial cell anergy limit tumor/T-cell interactions. We have found that NGR-TNF, a tumor vasculature-homing derivative of TNF, selectively activates endothelial cells in neoplastic tissues and induces the release of chemokines that favor tumor infiltration by T cells, thereby enhancing the efficacy of active and adoptive immunotherapy.
authors.affiliation: Cellular Immunology Unit; Gene Therapy and Bio-Immunotherapy of Cancer (PIBIC); San Raffaele Scientific Institute; Milan, Italy ; Program of Immunology, Gene Therapy and Bio-Immunotherapy of Cancer (PIBIC); San Raffaele Scientific Institute; Milan, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bellone
authors.forename: Arianna
authors.initials: A
authors.lastname: Calcinotto
authors.forename: Angelo
authors.initials: A
authors.lastname: Corti