title: [Differentiated thyroid cancer in childhood].
abstract: Thyroid carcinoma is a rare disease in children, and is mostly of the papillary histological type. Lymph node metastases are frequent at diagnosis, being present in 23 to 74% of the cases and can reveal the cancer in about one fourth of cases. Lung metastases are present at initial diagnosis in 6 to 20% of cases. The main known risk factor for thyroid cancer is a previous history of radiation exposure. Treatment includes surgery with total thyroidectomy and lymph node dissection and radioiodine therapy in case of extensive disease and distant metastases. Life-long thyroxine treatment is given to all patients. Long term prognosis is favourable, but thyroid cancer related deaths have been reported some decades after initial treatment.
authors.affiliation: Institut Gustave-Roussy, université Paris-Sud, service de médecine nucléaire et de cancérologie endocrinienne, Villejuif, France. leboulleux@igr.fr
authors.forename: Sophie
authors.initials: S
authors.lastname: Leboulleux
authors.forename: Dana
authors.initials: D
authors.lastname: Hartl
authors.forename: Eric
authors.initials: E
authors.lastname: Baudin
authors.forename: Martin
authors.initials: M
authors.lastname: Schlumberger
mesh_terms: D000293:Adolescent; D002277:Carcinoma / Q000235:genetics / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D002291:Carcinoma, Papillary / Q000235:genetics / Q000473:pathology / Q000556:secondary / Q000628:therapy; D002648:Child; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000556:secondary; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D011379:Prognosis; D035583:Rare Diseases / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D016606:Thyroid Nodule / Q000235:genetics / Q000473:pathology
chemical_list: D007457:Iodine Radioisotopes