title: Recent progress in biocatalysis using supercritical carbon dioxide.
abstract: The latest advances in biocatalysis using supercritical carbon dioxide (scCO(2)) are reviewed. Stability and stabilization methodologies of enzymes in scCO(2) as well as reactions for organic synthesis are described. Especially, varieties of examples for lipase-catalyzed synthesis of chiral compounds using scCO(2) are given. Furthermore, asymmetric reduction by alcohol dehydrogenase in scCO(2) and carboxylation by decarboxylase in scCO(2) are also introduced.
authors.affiliation: Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, Japan. tmatsuda@bio.titech.ac.jp
authors.forename: Tomoko
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism; D055162:Biocatalysis; D002245:Carbon Dioxide / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D004795:Enzyme Stability; D008049:Lipase / Q000378:metabolism; D012997:Solvents / Q000737:chemistry*
chemical_list: D012997:Solvents; D002245:Carbon Dioxide; D000426:Alcohol Dehydrogenase; D008049:Lipase