title: Glycogen as a biodegradable construction nanomaterial for in vivo use.
abstract: It is demonstrated that glycogen as a biodegradable and inexpensive material coming from renewable resources can be used as a carrier for the construction of in vivo imaging nanoagents. The model system considered is composed of glycogen modified with gadolinium and fluorescent labels. Systematic studies of properties of these nanocarriers by a variety of physical methods and results of in vivo tests of biodegradability are reported. This represents, to the authors' best knowledge, the first such use of glycogen.
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v. v. i., Heyrovský Sq. 2, 162 06 Prague 6, Czech Republic.
authors.forename: Sergey K
authors.initials: SK
authors.lastname: Filippov
authors.forename: Ondrej
authors.initials: O
authors.lastname: Sedlacek
authors.forename: Anna
authors.initials: A
authors.lastname: Bogomolova
authors.forename: Miroslav
authors.initials: M
authors.lastname: Vetrik
authors.forename: Daniel
authors.initials: D
authors.lastname: Jirak
authors.forename: Jan
authors.initials: J
authors.lastname: Kovar
authors.forename: Jan
authors.initials: J
authors.lastname: Kucka
authors.forename: Sara
authors.initials: S
authors.lastname: Bals
authors.forename: Stuart
authors.initials: S
authors.lastname: Turner
authors.forename: Petr
authors.initials: P
authors.lastname: Stepanek
authors.forename: Martin
authors.initials: M
authors.lastname: Hruby
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D005453:Fluorescence; D005682:Gadolinium; D006003:Glycogen / Q000737:chemistry*; D006571:Heterocyclic Compounds; D046529:Microscopy, Electron, Transmission; D057054:Molecular Imaging / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry*; D009942:Organometallic Compounds
chemical_list: D001672:Biocompatible Materials; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D006003:Glycogen; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium