title: Mixed glioneuronal tumor: a dysembryoplastic neuroepithelial tumor with rosette-forming glioneuronal tumor component.
abstract: Neuronal and mixed neuronal-glial tumors of the CNS show a wide spectrum of components. Here, we report an unusual case of brain tumor with combined histological features of dysembryoplastic neuroepithelial tumor (DNT) and rosette-forming glioneuronal tumor (RGNT) in a 23-year-old man. It arose in the left anterior cingulate cortex with a pseudo-polycystic appearance on neuroimaging. Histological features contained the "specific glioneuronal element" mimicking DNT and the components of distinct neurocytic rosettes with a center of neuropil islands and pilocytic astrocytoma resembling RGNT. Although the mechanisms of mixed glioneuronal tumor are far from being well-known, their co-existence might suggest a possible etiologic relationship between DNT and RGNT.
authors.affiliation: Department of Neuropathology, Institute of Neurology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Xiong
authors.forename: LiLi
authors.initials: L
authors.lastname: Ding
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Haixia
authors.initials: H
authors.lastname: Chen
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018193:Neoplasms, Complex and Mixed / Q000473:pathology* / Q000601:surgery; D018302:Neoplasms, Neuroepithelial / Q000473:pathology* / Q000601:surgery; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor