title: Effects of ethanolic extract of Tetrapleura tetraptera fruit on serum lipid profile and kidney function in male Dutch-white rabbits.
abstract: BACKGROUND
  Tetrapleura tetraptera fruit is widely used in Nigeria as a spice and for treatment of various medical ailments. Reports indicate that feeding of extracts to animals produced some toxic effects and pathological lesions in some organs.
  
  
  OBJECTIVE
  This study was designed to investigate the effects of 10 days oral administration of the ethanolic extract of Tetrapleura tetraptera (TTE) on the lipid profile and kidney function in male rabbits.
  
  
  METHODS
  Twenty healthy, acclimatized male rabbits weighing 1.4 - 1.6 kg were randomly divided into four groups. Group 1 served as control and received only water while groups 2, 3 and 4 were administered 50, 100 and 150 mg/kg bodyweight of TTE respectively. Fasting serum from all groups were analyzed for lipid profile and kidney function parameters using standard protocols. Data were analyzed using student's t-test and ANOVA.
  
  
  RESULTS
  Tetrapleura tetraptera extract elicited reduction in serum triacylglycerols, elevation of LDL-cholesterol and alteration of kidney function parameters in male rabbits.
  
  
  CONCLUSIONS
  Ethanolic extract of Tetrapleura tetraptera may predispose to hypertension and cardiovascular diseases.
authors.affiliation: Department of Biochemistry, College of Medicine, University of Lagos, Nigeria. loladot2001@yahoo.com
authors.forename: O S
authors.initials: OS
authors.lastname: Odesanmi
authors.forename: R A
authors.initials: RA
authors.lastname: Lawal
authors.forename: S A
authors.initials: SA
authors.lastname: Ojokuku
mesh_terms: D000818:Animals; D008078:Cholesterol, LDL / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000097:blood; D000431:Ethanol; D007668:Kidney / Q000187:drug effects; D007677:Kidney Function Tests; D008055:Lipids / Q000097:blood*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D031305:Tetrapleura; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D004573:Electrolytes; D008055:Lipids; D010936:Plant Extracts; D014280:Triglycerides; D000431:Ethanol