title: Impact of glutathione S-transferase T1 gene polymorphisms on acute cellular rejection in living donor liver transplantation.
abstract: It has previously been demonstrated that glutathione S-transferase T1 (GSTT1) genetic mismatch between recipient and donor is a risk factor for developing immune-mediated hepatitis following liver transplantation and for antibody-mediated rejection in renal transplantation. Little is known whether the GSTT1 gene polymorphism affects the incidence of acute cellular rejection (ACR) following living donor liver transplantation (LDLT). Patients underwent LDLT at Nagoya University or Kyoto University, Japan, between 2004 and 2009. Genotyping of GSTT1 genes (null or present genotype) was conducted in recipients and donors. A total of 155 LDLT cases were examined. Forty-seven recipients (30.3%) developed early ACR. There was no association of recipient GSTT1 genotype with ACR incidence. However, ACR incidence was significantly higher in recipients transplanted from GSTT1 present genotype donors than in those transplanted from GSTT1 null genotype donors [odds ratio (OR)=2.64, 95% confidence interval (CI)=1.12-5.83, p=0.016]. Moreover, GSTT1 recipient/donor genotype mismatch (present/null or null/present) was significantly associated with ACR development (OR=2.28, 95% CI=1.12-4.61, p=0.022). The genotyping of GSTT1 in recipients and donors might be useful to stratify the liver transplant recipients according to risk of ACR.
authors.affiliation: Department of Transplantation Surgery, Nagoya University, Nagoya, Japan. kamei@med.nagoya-u.ac.jp
authors.forename: Hideya
authors.initials: H
authors.lastname: Kamei
authors.forename: Satohiro
authors.initials: S
authors.lastname: Masuda
authors.forename: Taro
authors.initials: T
authors.lastname: Nakamura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Oike
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ogura
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Takada
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamajima
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006084:Graft Rejection / Q000209:etiology / Q000235:genetics*; D006648:Histocompatibility / Q000235:genetics; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011183:Postoperative Complications / Q000235:genetics*; D055815:Young Adult
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase