title: Renal choriocarcinoma: gestational or germ cell origin?
abstract: Choriocarcinoma is a rare, highly malignant trophoblastic tumor with gestational or, rarely, germ cell origin. Primary extragenital localization is extremely rare. This report describes a choriocarcinoma case clinically mimicking a primary renal cell carcinoma with multiplex pulmonary metastases. Differentiation from a sarcomatoid renal cell carcinoma with trophoblastic differentiation and identification of the exact origin, namely gestational or germ cell origin by molecular genetic methods is of great importance as it helps determine the prognosis and the most effective therapy of the disease. The Investigator Hexaplex ESS Kit was used for DNA polymorphism studies. This showed foreign alleles in the tumor DNA that confirmed the presence of paternal DNA and the gestational origin of the tumor.
authors.affiliation: National Institute of Oncology, Budapest, Hungary. vereczkey.ildiko@oncol.hu
authors.forename: Ildikó
authors.initials: I
authors.lastname: Vereczkey
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Csernák
authors.forename: Judit
authors.initials: J
authors.lastname: Olasz
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Küronya
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szentirmay
authors.forename: Erika
authors.initials: E
authors.lastname: Tóth
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000188:drug therapy / Q000235:genetics / Q000556:secondary*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D041322:Chromosomes, Human, Y / Q000235:genetics; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005838:Genotype; D005854:Germ Cells / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000556:secondary*; D009392:Nephrectomy; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D004273:DNA, Neoplasm