title: Head and neck sarcomas: epidemiology, pathology, and management.
abstract: Sarcomas of the head, neck, and skull base represent a heterogeneous group of tumors with distinct prognostic features. There have been significant improvements in characterizing these sarcomas using traditional morphologic assessments and more recent immunohistochemical analysis. Surgery is the mainstay of treatment followed by radiation therapy. Treatment modalities have changed in select pediatric sarcomas, for which new chemotherapeutic combinations have improved survival statistics. The high rate of distant failure emphasizes the need for novel systemic and directed molecular therapies. Tumor grade, size, and margin status are key factors in survival.
authors.affiliation: Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. joneill@rcsi.ie
authors.forename: James Paul
authors.initials: JP
authors.lastname: O'Neill
authors.forename: Mark H
authors.initials: MH
authors.lastname: Bilsky
authors.forename: Dennis
authors.initials: D
authors.lastname: Kraus
mesh_terms: D002813:Chondrosarcoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D005354:Fibrosarcoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D006394:Hemangiosarcoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D051677:Histiocytoma, Malignant Fibrous / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D008080:Liposarcoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D012516:Osteosarcoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D012208:Rhabdomyosarcoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D012509:Sarcoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*