title: Highly regioselective C-N bond formation through C-H azolation of indoles promoted by iodine in aqueous media.
abstract: An efficient and metal-free method for the direct C-N coupling of indoles with azoles to produce 2-(azol-1-yl)indoles in aqueous solution has been developed. This reaction proceeded highly regioselectively to provide a variety of indole derivatives with good to excellent yields.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, 510640, China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Wu
authors.forename: Jing-Mei
authors.initials: JM
authors.lastname: Huang
mesh_terms: D001393:Azoles / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D001393:Azoles; D007211:Indoles; D014867:Water; D007455:Iodine