title: Direct sp3 C-H amination of nitrogen-containing benzoheterocycles mediated by visible-light-photoredox catalysts.
abstract: Visible-light-mediated direct sp(3) C-H amination of benzocyclic amines via α-aminoalkyl radicals by using photoredox catalysts is described here. The obtained N,N-acetals were also successfully applied for carbon-carbon bond forming reactions with carbon nucleophiles. The procedure is suitable for a late-stage modification of C-H bonds to C-C bonds.
authors.affiliation: Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyake
authors.forename: Kazunari
authors.initials: K
authors.lastname: Nakajima
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nishibayashi
mesh_terms: D000080:Acetals / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006860:Hydrogen Bonding; D008027:Light; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D055668:Photochemical Processes
chemical_list: D000080:Acetals; D006571:Heterocyclic Compounds; D009584:Nitrogen