title: [Analysis of the diastolic function by myocardial perfusion gated SPECT after coronary revascularization in acute myocardial infarction].
abstract: OBJECTIVE
  To evaluate the evolutive changes in diastolic function after percutaneous coronary revascularization (PCR) in acute myocardial infarction (AMI), using myocardial perfusion gated SPECT.
  
  
  METHODS
  Thirty-two patients (mean 61.9±9.7 years, 7 women) were studied by two at rest gated SPECT: the first gated-SPECT-1 was performed with an injection of a dose of (99m)Tc-tetrofosmin prior to PCR and the second gated-SPECT-2 between the fourth and fifth weeks after AMI. Changes of peak filling rate (PFR) and the time to peak filling rate (TTPF) were assessed between both studies, and were related to the extent of salvaged myocardium (SM), end-diastolic (EDV) and end-systolic (ESV) volumes, and left ventricular ejection fraction (LVEF) changes.
  
  
  RESULTS
  An improvement was observed in diastolic function parameters Gated-SPECT-2: PFR increased significantly (P=0.011) while the TTPF decreased without reaching statistical significance (P=0.288). In multivariate analysis, adjusted by clinical and coronary variables, improvement of PFR was significantly associated with percentage of SM (P=0.030), increase in LVEF (P=0.004) and with ESV volume reduction (P=0.005). Improvement of TTPF was only related significantly to the percentage of SM (P=0.046). PFR increased 0.01 EDV/sec. and TTPF decreased 1.14ms for each cm(2) increase of the area of SM.
  
  
  CONCLUSIONS
  After PCR in AMI, the myocardial perfusion gated SPECT makes it possible to assess the significant improvement in diastolic function mainly related to the amount of MS.
authors.affiliation: Unidad de Cardiología Nuclear, Hospital Universitario Vall d'Hebron, Institut de Recerca, Universidad Autónoma de Barcelona, Barcelona, España. guirom@telefonica.net
authors.forename: G
authors.initials: G
authors.lastname: Romero-Farina
authors.forename: S
authors.initials: S
authors.lastname: Aguadé-Bruix
authors.forename: M N
authors.initials: MN
authors.lastname: Pizzi
authors.forename: G
authors.initials: G
authors.lastname: Cuberas-Borrós
authors.forename: G
authors.initials: G
authors.lastname: De León
authors.forename: J
authors.initials: J
authors.lastname: Castell-Conesa
authors.forename: D
authors.initials: D
authors.lastname: García-Dorado
authors.forename: J
authors.initials: J
authors.lastname: Candell-Riera
mesh_terms: D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; D003971:Diastole; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000601:surgery; D055414:Myocardial Perfusion Imaging; D009204:Myocardial Revascularization; D011446:Prospective Studies