title: Temporal dynamics of parvalbumin-expressing axo-axonic and basket cells in the rat medial prefrontal cortex in vivo.
abstract: Axo-axonic interneurons, innervating exclusively axon initial segments, and parvalbumin-expressing basket interneurons, targeting somata, dendrites, and spines of pyramidal cells, have been proposed to control neuronal activity in prefrontal circuits. We recorded the spike-timing of identified neurons in the prelimbic cortex of anesthetized rats, and show that axo-axonic cells increase their firing during tail pinch-induced brain state-activation. In addition, axo-axonic cells differ from other GABAergic parvalbumin-expressing cells in their spike timing during DOWN- to UP-state transitions of slow oscillations and in their coupling to gamma and spindle oscillations. The distinct firing dynamics and synaptic targets of axo-axonic and other parvalbumin-expressing cells provide differential contributions to the temporal organization of prefrontal networks.
authors.affiliation: Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH, United Kingdom.|Center for Brain Research, Department of Cognitive Neurobiology, Medical University of Vienna, 1090 Vienna, Austria.
authors.forename: Lema
authors.initials: L
authors.lastname: Massi
authors.affiliation: Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH, United Kingdom.|Center for Brain Research, Department of Cognitive Neurobiology, Medical University of Vienna, 1090 Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Lagler
authors.affiliation: Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH, United Kingdom.|Center for Brain Research, Department of Cognitive Neurobiology, Medical University of Vienna, 1090 Vienna, Austria.
authors.forename: Katja
authors.initials: K
authors.lastname: Hartwich
authors.affiliation: Center for Brain Research, Department of Cognitive Neurobiology, Medical University of Vienna, 1090 Vienna, Austria.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Borhegyi
authors.affiliation: Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH, United Kingdom.|Center for Brain Research, Department of Cognitive Neurobiology, Medical University of Vienna, 1090 Vienna, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Somogyi
authors.affiliation: Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH, United Kingdom.|Center for Brain Research, Department of Cognitive Neurobiology, Medical University of Vienna, 1090 Vienna, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Klausberger
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D003712:Dendrites / Q000502:physiology; D055724:Electrophysiological Phenomena; D005071:Evoked Potentials / Q000502:physiology; D007150:Immunohistochemistry; D007395:Interneurons / Q000378:metabolism*; D009415:Nerve Net / Q000166:cytology / Q000502:physiology; D010320:Parvalbumins / Q000378:metabolism*; D010812:Physical Stimulation; D017397:Prefrontal Cortex / Q000166:cytology / Q000378:metabolism*; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010320:Parvalbumins