title: Differential gene expression profiles in spontaneously hypertensive             rats induced by administration of enalapril and nifedipine.
abstract: Enalapril and nifedipine are used as antihypertensive drugs; however, the             therapeutic target molecules regulated by enalapril and nifedipine have yet to             be fully identified. The aim of this study was to identify novel target genes             that are specifically regulated by enalapril and nifedipine in tissues from spontaneously             hypertensive rats (SHR) using DNA microarray analysis. We found that administration             of SHR with enalapril and nifedipine differentially regulated 33 genes involved             in the pathogenesis of cardiovascular diseases. Furthermore, we identified 16             genes that have not previously been implicated in cardiovascular diseases, including             interleukin-24 (IL-24). Among them, exogenous administration of IL-24 attenuated             the expression of vascular inflammation and hypertension-related genes induced             by H2O2 treatment in mouse vascular smooth muscle (MOVAS) cells. This study provides             valuable information for the development of novel antihypertensive drugs. In addition,             the genes identified may be of use as biomarkers and therapeutic targets for cardiovascular             diseases, including hypertension.
authors.affiliation: School of Biological Sciences and Technology, Chonnam National                     University, Gwangju 500‑757, Republic of Korea.
authors.forename: Ki-Mo
authors.initials: KM
authors.lastname: Lee
authors.forename: Haeng-A
authors.initials: HA
authors.lastname: Kang
authors.forename: Chang-Bo
authors.initials: CB
authors.lastname: Ko
authors.forename: Eun-Ha
authors.initials: EH
authors.lastname: Oh
authors.forename: Min
authors.initials: M
authors.lastname: Park
authors.forename: Hwa-Youn
authors.initials: HY
authors.lastname: Lee
authors.forename: Ha-Rim
authors.initials: HR
authors.lastname: Choi
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Yun
authors.forename: Woon-Won
authors.initials: WW
authors.lastname: Jung
authors.forename: Jae-Wook
authors.initials: JW
authors.lastname: Oh
authors.forename: Hyung-Sik
authors.initials: HS
authors.lastname: Kang
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004656:Enalapril / Q000008:administration & dosage*; D006321:Heart / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000633:toxicity; D006973:Hypertension / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy; D007378:Interleukins / Q000008:administration & dosage; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D032389:Myocytes, Smooth Muscle / Q000187:drug effects*; D009543:Nifedipine / Q000008:administration & dosage*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D060888:Real-Time Polymerase Chain Reaction; D015203:Reproducibility of Results; D059467:Transcriptome; D000099180:Interleukin-24
chemical_list: D000959:Antihypertensive Agents; D004656:Enalapril; D006861:Hydrogen Peroxide; D007378:Interleukins; D009543:Nifedipine; D000099180:Interleukin-24