title: Avascular necrosis of the proximal carpal row of the wrist. A possible complication of bisphosphonate administration.
abstract: Reports of coexisting osteonecrosis of more than one carpal bone are rare. We report an osteonecrosis of the entire proximal carpal row of the wrist, started briefly after intravenous bisphosphonate administration. The use of bisphosphonates for the treatment of osteoporosis is increasing. Osteonecrosis of the jaw (ONJ) is one of the known adverse effects during chronic treatment with bisphosphonates. This case is reported to make clinicians aware of a possible causative link between bisphosphonate use and osteonecrosis of other bones.
authors.affiliation: Department of Orthopaedic Surgery, Upper Limb Surgery, University Hospitals of Leuven, Pellenberg Campus, Weligerveld 1, B-3212 Pellenberg, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Didden
authors.forename: L
authors.initials: L
authors.lastname: De Smet
authors.forename: L
authors.initials: L
authors.lastname: Vandenberghe
authors.forename: R
authors.initials: R
authors.lastname: Sciot
authors.forename: I
authors.initials: I
authors.lastname: Degreef
mesh_terms: D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002348:Carpal Bones / Q000473:pathology* / Q000601:surgery; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D007262:Infusions, Intravenous; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced* / Q000601:surgery; D010024:Osteoporosis / Q000188:drug therapy*; D012307:Risk Factors; D016896:Treatment Outcome; D014953:Wrist; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid