title: Magnetic field activated lipid-polymer hybrid nanoparticles for stimuli-responsive drug release.
abstract: Stimuli-responsive nanoparticles (SRNPs) offer the potential of enhancing the therapeutic efficacy and minimizing the side-effects of chemotherapeutics by controllably releasing the encapsulated drug at the target site. Currently controlled drug release through external activation remains a major challenge during the delivery of therapeutic agents. Here we report a lipid-polymer hybrid nanoparticle system containing magnetic beads for stimuli-responsive drug release using a remote radio frequency (RF) magnetic field. These hybrid nanoparticles show long-term stability in terms of particle size and polydispersity index in phosphate-buffered saline (PBS). Controllable loading of camptothecin (CPT) and Fe(3)O(4) in the hybrid nanoparticles was demonstrated. RF-controlled drug release from these nanoparticles was observed. In addition, cellular uptake of the SRNPs into MT2 mouse breast cancer cells was examined. Using CPT as a model anticancer drug the nanoparticles showed a significant reduction in MT2 mouse breast cancer cell growth in vitro in the presence of a remote RF field. The ease of preparation, stability, and controllable drug release are the strengths of the platform and provide the opportunity to improve cancer chemotherapy.
authors.affiliation: Materials Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Seong Deok
authors.initials: SD
authors.lastname: Kong
authors.forename: Marta
authors.initials: M
authors.lastname: Sartor
authors.forename: Che-Ming Jack
authors.initials: CM
authors.lastname: Hu
authors.forename: Weizhou
authors.initials: W
authors.lastname: Zhang
authors.forename: Liangfang
authors.initials: L
authors.lastname: Zhang
authors.forename: Sungho
authors.initials: S
authors.lastname: Jin
mesh_terms: D000818:Animals; D002166:Camptothecin / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry*; D008055:Lipids / Q000138:chemical synthesis / Q000737:chemistry*; D060526:Magnetic Fields; D051379:Mice; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011100:Polyglycolic Acid / Q000138:chemical synthesis / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011846:Radio Waves; D013997:Time Factors
chemical_list: D008055:Lipids; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D002166:Camptothecin