title: A search to identify genetic risk factors for endometriosis.
abstract: OBJECTIVE
  To search for molecular markers of endometriosis the following polymorphisms: p53 codon 72 Pro (apoptosis), TNF alpha-308 (inflammation), VEGF-1164AA (angiogenesis), and SOD2 (oxidative stress) were investigated.
  
  
  METHODS
  Forty-two women-24 with surgically proven endometriosis and 18 with no endometriosis found at the time of laparoscopy-had buccal swabs taken for DNA analyses of 4 gene polymorphisms including p53codon72, TNF-308 G/A, VEGF-1154G/A, SOD Ala16Val DNA. The frequencies of genotypes and alleles of these polymorphisms were compared between women with and without endometriosis.
  
  
  RESULTS
  No specific gene mutation differences for the four genes tested nor differences in the frequencies of heterozygous and homozygous mutations were found between patients with endometriosis and controls. In addition, no differences in allelic frequencies of the four genetic polymorphisms were observed between patients with endometriosis and control.
  
  
  CONCLUSIONS
  Endometriosis is not associated with gene mutations for p53codon72, TNF-308 G/A, VEGF-1154G/A, SOD Ala16Val.
authors.affiliation: Oak Brook Institute of Endoscopy, Oak Brook, IL, USA. cbcoulam@aol.com
authors.forename: Carlos
authors.initials: C
authors.lastname: Rotman
authors.forename: Larry
authors.initials: L
authors.lastname: Fischel
authors.forename: Gabriela
authors.initials: G
authors.lastname: Cortez
authors.forename: Hisham
authors.initials: H
authors.lastname: Greiss
authors.forename: Nasiruddin
authors.initials: N
authors.lastname: Rana
authors.forename: John
authors.initials: J
authors.lastname: Rinehart
authors.forename: Carolyn B
authors.initials: CB
authors.lastname: Coulam
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000235:genetics; D004252:DNA Mutational Analysis; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics; D011110:Polymorphism, Genetic; D012306:Risk; D013482:Superoxide Dismutase / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D055815:Young Adult; D000099156:Superoxide Dismutase 2
chemical_list: D005819:Genetic Markers; D013482:Superoxide Dismutase; D014409:Tumor Necrosis Factor-alpha; D016159:Tumor Suppressor Protein p53; D042461:Vascular Endothelial Growth Factor A; D000099156:Superoxide Dismutase 2