title: N-methyl-D-aspartate (NMDA)-mediated excitotoxic damage: a mouse model of acute retinal ganglion cell damage.
abstract: The animal model of N-methyl-D-aspartate (NMDA)-induced excitotoxic damage of retinal ganglion cells (RGC) is widely used to study the molecular mechanisms of RGC apoptosis and/or its prevention by neuroprotective agents. This chapter provides protocols for applying NMDA-induced excitotoxic damage to RGC of mouse eyes and for subsequent measuring of the extent of the resulting damage.
authors.affiliation: Institute for Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany.
authors.forename: Roswitha
authors.initials: R
authors.lastname: Seitz
authors.forename: Ernst R
authors.initials: ER
authors.lastname: Tamm
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004195:Disease Models, Animal; D018690:Excitatory Amino Acid Agonists; D005123:Eye / Q000166:cytology / Q000473:pathology; D005128:Eye Diseases / Q000139:chemically induced* / Q000473:pathology; D051379:Mice; D016202:N-Methylaspartate; D018696:Neuroprotective Agents / Q000494:pharmacology; D012165:Retinal Ganglion Cells / Q000473:pathology*
chemical_list: D018690:Excitatory Amino Acid Agonists; D018696:Neuroprotective Agents; D016202:N-Methylaspartate