title: Localization of c-MYB in differentiated cells during postnatal molar and alveolar bone development.
abstract: The MYB family of transcription activators has been associated with a high proliferation rate and an undifferentiated state of cells in a number of tissues. Recently emerging data suggest that these molecules may also play a role in differentiation. In this study, the pattern of expression of c-MYB was followed during postnatal stages of mouse molar odontogenesis using immunohistochemistry on serial sections. Along with an abundance of the c-MYB protein in proliferating zones, we confirmed the presence of this protein in differentiated ameloblasts, odontoblasts, and osteoblasts. In addition, c-MYB was also found in cementoblasts and alveolar fibroblasts. These findings suggest integration of c-MYB into regulatory networks during hard-tissue differentiation and mineralization.
authors.affiliation: Institute of Animal Physiology and Genetics CAS, v.v.i, Brno, Czech Republic.
authors.forename: Vlasta
authors.initials: V
authors.lastname: Lungova
authors.forename: Marcela
authors.initials: M
authors.lastname: Buchtova
authors.forename: Eva
authors.initials: E
authors.lastname: Janeckova
authors.forename: Abigail S
authors.initials: AS
authors.lastname: Tucker
authors.forename: Lucia
authors.initials: L
authors.lastname: Knopfova
authors.forename: Jan
authors.initials: J
authors.lastname: Smarda
authors.forename: Eva
authors.initials: E
authors.lastname: Matalova
mesh_terms: D000539:Alveolar Process / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D000565:Ameloblasts / Q000378:metabolism; D000818:Animals; D001846:Bone Development / Q000235:genetics / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics*; D003239:Connective Tissue Cells / Q000378:metabolism; D003739:Dental Cementum / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics* / Q000502:physiology; D016259:Genes, myc / Q000235:genetics*; D020287:In Situ Nick-End Labeling; D051379:Mice; D008963:Molar / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D009805:Odontogenesis / Q000235:genetics*; D020598:Proto-Oncogene Proteins c-myb / Q000032:analysis / Q000235:genetics / Q000378:metabolism
chemical_list: D020598:Proto-Oncogene Proteins c-myb