title: Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties.
abstract: Hyaluronic acid (HA) hydrogels were structured in the form of porous monoliths by means of the ice-segregation-induced self-assembly (ISISA) method coupled with freeze-drying. Physical and chemical parameters were explored in order to fine-tune the microstructure and the incidence on both swelling and dissolution behavior in aqueous media. Gentamicin-loaded HA matrices with tuned drug release properties were also prepared; their inherent properties and behavior in solution are discussed in the framework of thermal analysis and scanning electron microscopy inspection.
authors.affiliation: INQUIMAE-DQIAQF, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II, C1428EHA, Buenos Aires, Argentina.
authors.forename: Yanina
authors.initials: Y
authors.lastname: Minaberry
authors.forename: Diego A
authors.initials: DA
authors.lastname: Chiappetta
authors.forename: Alejandro
authors.initials: A
authors.lastname: Sosnik
authors.forename: Matías
authors.initials: M
authors.lastname: Jobbágy
mesh_terms: D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics; D005839:Gentamicins / Q000737:chemistry / Q000493:pharmacokinetics; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000493:pharmacokinetics; D020100:Hydrogels / Q000737:chemistry / Q000493:pharmacokinetics; D008863:Microspheres; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D005839:Gentamicins; D020100:Hydrogels; D006820:Hyaluronic Acid