title: Amperometric nitric oxide sensor based on nanoporous platinum phthalocyanine modified electrodes.
abstract: This article describes the fabrication of electropolymerized Metallo 4', 4″, 4‴, 4'''' tetra-amine phthalocyanine (poly-MTAPc) modified electrodes for the detection of nitric oxide (NO) in phosphate-buffered saline (PBS) at pH 7.4. A two-step synthetic protocol using a laboratory microwave reactor was adopted to provide three MTAPc complexes bearing different metal centers (M = Cu(2+): CuTAPc, M = Zn(2+): ZnTAPc, and M = Pt(2+): PtTAPc). The MTAPc complexes and the intermediates were characterized by MALDI-TOF mass spectrometry, UV-vis spectroscopy, (1)H NMR spectroscopy, and elemental analysis. The MTAPc products were separately electropolymerized either onto a glassy carbon (GC) electrode as a thin-film or within the pores of Anodisc nanoporous alumina membrane as a densely packed array of poly-MTAPc nanotubes to produce two electrode systems. In the latter system, the surface area enhancement provided by the nanotube-arrayed morphology of the poly-MTAPc enabled a high faradaic (signal) to capacitative (background) current during NO electro-oxidation. Amperometric detection of NO using these two electrode systems shows that the sensitivity and linear ranges were insensitive to the metal centers (M = Cu(2+), Zn(2+), and Pt(2+)) of the poly-MTAPc material.
authors.affiliation: Department of Chemistry, National University of Singapore, Singapore.
authors.forename: C M
authors.initials: CM
authors.lastname: Yap
authors.forename: G Q
authors.initials: GQ
authors.lastname: Xu
authors.forename: S G
authors.initials: SG
authors.lastname: Ang
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D055664:Electrochemical Techniques; D004566:Electrodes; D005465:Fluorocarbon Polymers / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D008872:Microwaves; D058608:Nanopores; D043942:Nanotubes / Q000737:chemistry; D009569:Nitric Oxide / Q000032:analysis*; D010084:Oxidation-Reduction; D010984:Platinum / Q000737:chemistry*
chemical_list: D005465:Fluorocarbon Polymers; D007211:Indoles; D054833:Isoindoles; D009569:Nitric Oxide; C040402:perfluorosulfonic acid; D010984:Platinum; D002244:Carbon; D000537:Aluminum Oxide; C013647:phthalocyanine