title: Phenolic antioxidants-functionalized quaternized chitosan: synthesis and antioxidant properties.
abstract: In this work, two kinds of phenolic antioxidants-functionalized quaternized chitosan were synthesized in order to develop aqueous soluble antioxidant-polymer conjugates. Quaternized chitosan conjugated with gallic acid or caffeic acid was carried out and the antioxidant properties of the products (namely gallic acid-quaternized chitosan and caffeic acid-quaternized chitosan) against hydroxyl-radical, superoxide-radical and DPPH-radical were evaluated in vitro, respectively. The scavenging activities of the obtained gallic acid-quaternized chitosan and caffeic acid-quaternized chitosan exhibit a remarkable improvement over those of either chitosan or quaternized chitosan. And the scavenging effect indices of the products were all higher than 90% at a concentration of 1000 μg/mL. Because gallic acid-quaternized chitosan and caffeic acid-quaternized chitosan are convenient to prepare and possess improved potential activities, these materials may represent an attractive new platform for utilizations of chitosan.
authors.affiliation: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Ren
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Dong
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.forename: Zhanyong
authors.initials: Z
authors.lastname: Guo
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry; D002109:Caffeic Acids / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D005707:Gallic Acid / Q000737:chemistry*; D010851:Picrates / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013481:Superoxides / Q000737:chemistry
chemical_list: D001713:Biphenyl Compounds; D002109:Caffeic Acids; D016166:Free Radical Scavengers; D005609:Free Radicals; C118071:N-trimethyl chitosan chloride; D010851:Picrates; D013481:Superoxides; D005707:Gallic Acid; D048271:Chitosan; C004931:1,1-diphenyl-2-picrylhydrazyl; C040048:caffeic acid