title: Variations in the expression and distribution pattern of AQP5 in acinar cells of patients with sialadenosis.
abstract: Previously, we pointed out on a possible role of aquaporin 5 (AQP5) in the development of sialadenosis. The goal of the present study was to further assess the association of AQP5 in the development of this salivary gland disease. The acinar diameter and mean surface area appeared elevated in sialadenosis tissues, which is a typical observation in this disease. AQP5 expression was evaluated by immunohistochemistry using tissue samples derived from salivary glands of patients with confirmed sialadenosis either as a primary diagnosis or as a secondary diagnosis within the framework of other salivary gland diseases. Normal salivary gland tissue served as a control. In sialadenosis tissues, the AQP5 signal at the apical plasma membrane of acinar cells frequently appeared stronger compared with that in normal salivary glands. In addition, the distribution of AQP5 at the apical region seemed to differ between normal and sialadenosis tissues, where AQP5 frequently was diffusely distributed near or at the apical plasma membrane of the acinar cells in contrast to normal controls where the AQP5 signal was strictly confined to the apical plasma membrane. These observations suggest that sialadenosis is associated with a different AQP5 expression and distribution pattern in salivary acinar cells.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen and Marburg, Marburg, Germany.
authors.forename: Afshin
authors.initials: A
authors.lastname: Teymoortash
authors.forename: Susanne
authors.initials: S
authors.lastname: Wiegand
authors.forename: Martin
authors.initials: M
authors.lastname: Borkeloh
authors.forename: Michael
authors.initials: M
authors.lastname: Bette
authors.forename: Annette
authors.initials: A
authors.lastname: Ramaswamy
authors.forename: Silke
authors.initials: S
authors.lastname: Steinbach-Hundt
authors.forename: Andreas
authors.initials: A
authors.lastname: Neff
authors.forename: Jochen A
authors.initials: JA
authors.lastname: Werner
authors.forename: Robert
authors.initials: R
authors.lastname: Mandic
mesh_terms: D061354:Acinar Cells / Q000378:metabolism; D051402:Aquaporin 5 / Q000235:genetics / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D012466:Salivary Gland Diseases / Q000378:metabolism / Q000473:pathology; D012469:Salivary Glands / Q000378:metabolism / Q000473:pathology
chemical_list: C496036:AQP5 protein, human; D051402:Aquaporin 5