title: No asthma, no parasites is a rare type of leukemia: chronic myeloid neoplasm with eosinophilia and abnormality of platelet-derived growth factor receptor alpha.
abstract: Chronic myeloid neoplasm with eosinophilia and abnormality of platelet-derived growth factor receptor alpha (PDGFRA), referred as chronic eosinophilic leukemia, is an extremely rare neoplasm where long-term prognosis is uncertain though a high grade of responsiveness to Imatinib has been reported. The mortality and morbidity associated with chronic eosinophilic leukemia is associated with the degree of tissue involvement, damage, or both at diagnosis. We discuss a case of a young male patient with past medical history of hypoglycemia that presented to the emergency room with a complaints of a sharp abdominal pain localized in the upper quadrants. Laboratories were remarkable for elevated white blood cells with eosinophils predominance, anemia and thrombocytopenia. Bone marrow biopsy dislocated a FIP1L1-PDGFRA fusion gene chronic eosinophilic leukemia. Physicians need to have a high index of suspicion of this rare entity since not all eosinophilias can be interpreted as asthma or parasitis infections.
authors.affiliation: Hematology-Oncology Section, VA Caribbean Healthcare System and San Juan City Hospital, San Juan, Puerto Rico. mscasiano002@yahoo.com
authors.forename: Mónica
authors.initials: M
authors.lastname: Santiago-Casiano
authors.forename: Jesse R
authors.initials: JR
authors.lastname: Alemán
authors.forename: Nelson A
authors.initials: NA
authors.lastname: Matos-Fernández
authors.forename: Wlliam
authors.initials: W
authors.lastname: Cáceres-Perkins
authors.forename: Maryknoll
authors.initials: M
authors.lastname: De La Paz
mesh_terms: D001249:Asthma; D003663:Decision Trees; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications*; D007951:Leukemia, Myeloid / Q000150:complications*; D008297:Male; D010272:Parasitic Diseases; D020796:Receptor, Platelet-Derived Growth Factor alpha; D055815:Young Adult
chemical_list: D020796:Receptor, Platelet-Derived Growth Factor alpha