title: Direct Monte Carlo computation of time-resolved fluorescence in heterogeneous turbid media.
abstract: We show that a multiexponential model for time-resolved fluorescence allows the use of an absorption-perturbation Monte Carlo (MC) approach based on stored photon path histories. This enables the rapid fitting of fluorescence yield, lifetimes, and background tissue absorptions in complex heterogeneous media within a few seconds, without the need for temporal convolutions or MC recalculation of photon path lengths. We validate this method using simulations with both a slab and a heterogeneous model of the mouse head.
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. ankumar@nmr.mgh.harvard.edu
authors.forename: Anand T N
authors.initials: AT
authors.lastname: Kumar
mesh_terms: D000042:Absorption; D000818:Animals; D001921:Brain / Q000378:metabolism; D051379:Mice; D009010:Monte Carlo Method; D017785:Photons; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013997:Time Factors