title: Siglec-6 expression is increased in placentas from pregnancies complicated by preterm preeclampsia.
abstract: Sialic acid immunoglobulin-like lectin (Siglec)-6 is a transmembrane receptor that binds sialyl-TN glycans and leptin. Among eutherian mammals, only human placentas express Siglec-6. Previous work has implicated Siglec-6 in preeclampsia (PE). Preeclampsia, a leading cause of maternal and perinatal morbidity and mortality, is characterized by placental abnormalities. This study provides a comprehensive analysis of Siglec-6 protein expression during human pregnancy by disease state (PE), biologic compartment (basal plate, chorionic villi, or maternal plasma), gestational age (24-41 weeks), and labor status. Siglec-6 protein was increased in both the basal plate and chorionic villi of preterm PE placentas (P < .05). However, expression did not differ at term by disease state, compartment, or labor status. Siglec-6 was not detectable in maternal serum. Overexpression of Siglec-6 protein in preterm PE placentas may contribute to or represent a response to PE pathogenesis and suggests that preterm PE pathogenesis is distinct from term PE.
authors.affiliation: Department of Obstetrics and Gynecology, University of Colorado, Aurora, CO 80045, USA.
authors.forename: Kristen K
authors.initials: KK
authors.lastname: Rumer
authors.forename: Jill
authors.initials: J
authors.lastname: Uyenishi
authors.forename: M Camille
authors.initials: MC
authors.lastname: Hoffman
authors.forename: Barbra M
authors.initials: BM
authors.lastname: Fisher
authors.forename: Virginia D
authors.initials: VD
authors.lastname: Winn
mesh_terms: D015703:Antigens, CD / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D016022:Case-Control Studies; D045744:Cell Line, Tumor; D005260:Female; D005865:Gestational Age; D006801:Humans; D007743:Labor, Obstetric; D037102:Lectins / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D047928:Premature Birth; D014162:Transfection; D014327:Trophoblasts / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D037102:Lectins; C120775:SIGLEC6 protein, human