title: Effect of aqueous extract of Elaeagnus angustifolia fruit on experimental cutaneous wound healing in rats.
abstract: The present study was conducted to investigate the histological changes and wound healing effect of aqueous extract of Elaeagnus angustifolia. After creating full-thickness skin wounds on the back of 45 male Sprague-Dawley rats they were randomly divided into three groups. Treated group received the extract, positive control group were treated with mupirocin ointment 2% and control group did not receive any treatment. Wound healing rates were calculated on days 3, 5, 8, 10, 12 and 15 post-wounding and the wound tissues were harvested at 5, 10, and 15 days for histological analysis and hydroxyproline content measurement. The results indicated a significant increase in the percentage of wound contraction and hydroxyproline content in the treated group comparing to the control and positive control groups. A significant increase in the assigned histological scores was observed at 10 and 15 days in the treated and positive control groups compared to the control group. The results demonstrate that aqueous extract of Elaeagnus angustifolia accelerates cutaneous wound healing, and its effect may be due to the increased re-epithelialization and collagen deposition in wound and so it can be considered as a therapeutic agent for wound healing.
authors.affiliation: Department of Biochemistry, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Mehrabani Natanzi
authors.forename: Parvin
authors.initials: P
authors.lastname: Pasalar
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kamalinejad
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Dehpour
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Tavangar
authors.forename: Roya
authors.initials: R
authors.lastname: Sharifi
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Ghanadian
authors.forename: Maryam
authors.initials: M
authors.lastname: Rahimi-Balaei
authors.forename: Siavash
authors.initials: S
authors.lastname: Gerayesh-Nejad
mesh_terms: D000287:Administration, Topical; D000818:Animals; D031263:Elaeagnaceae / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects*; D014867:Water / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D014867:Water