title: [Immunohistochemical study of CART-peptide in striato-nigral projections at dopamine loss].
abstract: The increase of CART-peptide optical density was found immunohistochemically in nucleus accumbens neurons and in their terminals in substantia nigra in Wistar rats after 28% reduction of dopaminergic neurons in a substantia nigra (in the model of lactacystin induced proteo some disfunction). At the same time after in vitro incubation of nigro-accumbal brain slice with AMPT (alpha-methyl-paratirosine--dopamine inhibitor) for 4 h the reduction of tyrosine hydroxylase optical density (the enzyme limiting dopamine synthesis) in substantia nigr neurons was found and optical density of CART-peptide in nucleus accumbens and substantia nigra was also revealed. In both experiments data about activation of CARTergic neurons in stria to-nigral projections testifies on participation of CART-peptide in compensatory brain mechanisms at dopamine loss and its role as modulator of dopaminergic brain neurons functional activity.
authors.forename: I V
authors.initials: IV
authors.lastname: Romanova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Chesnokova
authors.forename: A L
authors.initials: AL
authors.lastname: Mikhrina
mesh_terms: D000111:Acetylcysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D003342:Corpus Striatum / Q000166:cytology / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D004298:Dopamine; D059290:Dopaminergic Neurons / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000166:cytology / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000166:cytology / Q000378:metabolism*; D019805:alpha-Methyltyrosine / Q000494:pharmacology; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
chemical_list: D015853:Cysteine Proteinase Inhibitors; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein; C428723:cocaine- and amphetamine-regulated transcript protein (55-102); C067713:lactacystin; D019805:alpha-Methyltyrosine; D004298:Dopamine; D000111:Acetylcysteine