title: Long-term impact of infection on the preterm neonate.
abstract: Prematurely born infants are at increased risk for infection throughout their hospitalization. Various developmentally regulated processes involving the central nervous and respiratory systems may be disrupted by the proinflammatory state associated with infection, resulting in an increased risk for death, chronic lung disease, and adverse neurodevelopmental outcome. This review summarizes the current understanding of the long-term impact of infection and/or inflammation in preterm infants, including the risks associated with perinatal infection, early-onset sepsis, late-onset sepsis, and necrotizing enterocolitis.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30303, USA. iadamsc@emory.edu
authors.forename: Ira
authors.initials: I
authors.lastname: Adams-Chapman
mesh_terms: D017668:Age of Onset; D002657:Child Development; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood; D005315:Fetal Diseases / Q000097:blood / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood / Q000145:classification / Q000401:mortality / Q000503:physiopathology; D007239:Infections / Q000097:blood / Q000150:complications / Q000503:physiopathology; D007249:Inflammation / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D009420:Nervous System / Q000254:growth & development*; D018743:Perinatal Care / Q000379:methods; D054238:Perinatal Mortality; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D013995:Time
chemical_list: D016207:Cytokines