title: [A case of recurrent gastrointestinal stromal tumor with complete response from treatment with reduced dose of imatinib mesylate].
abstract: We report a patient who had a complete response by treatment with 200 mg of imatinib mesylate daily for peritoneal recurrences of gastrointestinal stromal tumor(GIST)of the stomach. On March 2007, a 68-year-old woman underwent distal gastrectomy for GIST of the stomach. On May 2007, peritoneal recurrences were recognized on CT scan, and treatment with 400 mg daily of imatinib mesylate was started. Because grade 2 systemic edema and rash developed one week later, the imatinib mesylate dose had to be reduced to 200 mg daily from July 2007. After reduction of imatinib mesylate, the adverse reactions resolved. Peritoneal dissemination disappeared on CT scan from April 2010, and complete response has been maintained for 18 months.
authors.affiliation: Dept. of Surgery, Baba Memorial Hospital.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Toyokawa
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Sadatoshi
authors.initials: S
authors.lastname: Shimizu
authors.forename: Tohru
authors.initials: T
authors.lastname: Inoue
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Ikehara
authors.forename: Katsuya
authors.initials: K
authors.lastname: Sakashita
authors.forename: Isao
authors.initials: I
authors.lastname: Kanehara
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Teraoka
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nishiguchi
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001549:Benzamides; D003131:Combined Modality Therapy; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D000068877:Imatinib Mesylate; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D012008:Recurrence; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate