title: [Effect of alpha2-adrenergic receptor antagonist yohimbine on thermoregulatory responses to cooling].
abstract: Ionoforetic yohimbine application to skin has a modulating effect on the thermoregulatory parameters. In thermoneutral conditions, yohimbine increases heat production and heat dissipation. At subsequent cooling, yohimbine facilitates the initiation of vascular and metabolic response by reducing the temperature threshold of both nonshivering and shivering thermogenesis. Under the influence of yohimbine the maximum value of both vascular and metabolic response increases. In strengthening the metabolic response the skeletal muscles shivering significantly contributes. In contrast to yohimbine, the norepinephrine thermogenic effect occurs by strengthening nonshivering thermogenesis. Features of the yohimbine influence on thermoregulatory parameters due to the dual localization and function of the alpha2-adrenergic receptors.
authors.forename: T V
authors.initials: TV
authors.lastname: Kozyreva
authors.forename: E Ia
authors.initials: EIa
authors.lastname: Tkachenko
authors.forename: E V
authors.initials: EV
authors.lastname: Gonsales
mesh_terms: D058669:Adrenergic alpha-2 Receptor Antagonists / Q000494:pharmacology*; D000818:Animals; D003080:Cold Temperature; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism*; D022722:Thermogenesis / Q000187:drug effects*; D015016:Yohimbine / Q000494:pharmacology*
chemical_list: D058669:Adrenergic alpha-2 Receptor Antagonists; D018341:Receptors, Adrenergic, alpha-2; D015016:Yohimbine