title: Hepatitis B revaccination for healthcare workers who are anti-HBs-negative after receiving a primary vaccination series.
abstract: BACKGROUND
  This study aimed to evaluate the response to hepatitis B (HB) revaccination of healthcare workers (HCW) who are negative for antibodies to HB surface antigen (anti-HBs) after a complete vaccination series.
  
  
  METHODS
  HCW whose anti-HBs test was performed > 90 days after a HB vaccination course were given a 4th dose. A post-vaccination test was done within 30 to 90 days.
  
  
  RESULTS
  One hundred and seventy HCW were enrolled: 126 (74.1%) were anti-HBs-positive after the 4th dose.
  
  
  CONCLUSIONS
  Rechecking anti-HBs after the 4th HB vaccine dose is a practical approach in case of post-vaccination tests performed >90 days after the full vaccination course.
authors.affiliation: Centro de Referência para Imunobiológicos Especiais Divisão de Clínica de Moléstias Infecciosas e Parasitárias, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Marta Heloisa
authors.initials: MH
authors.lastname: Lopes
authors.forename: Ana Marli Christovam
authors.initials: AM
authors.lastname: Sartori
authors.forename: Tatiany Viviany Gonçalves
authors.initials: TV
authors.lastname: Souza
authors.forename: Melissa
authors.initials: M
authors.lastname: Mascheretti
authors.forename: Tânia do Socorro Souza
authors.initials: Tdo S
authors.lastname: Chaves
mesh_terms: D000293:Adolescent; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006282:Health Personnel / Q000706:statistics & numerical data*; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000517:prevention & control; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines