title: Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls.
abstract: BACKGROUND
  Obesity has been associated with increased incidence of colorectal cancer. Adipose tissue dysfunction accompanied with alterations in the release of adipocytokines has been proposed to contribute to cancer pathogenesis and progression. The aim of this study was to analyze plasma concentrations of several adipose tissue expressed hormones in colorectal cancer patients (CRC) and morbidly obese (MO) patients and to compare these concentrations to clinicopathological parameters.
  
  
  METHODS
  Plasma concentrations of adiponectin, resistin, leptin, active plasminogen activator inhibitor (PAI)-1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-1 alpha, and tumor necrosis factor (TNF)-alpha were determined in 67 patients operated on for CRC (31 rectal cancers, 36 colon cancers), 37 patients operated on for morbid obesity and 60 healthy blood donors (BD).
  
  
  RESULTS
  Compared to BD, leptin concentrations were lowered in CRC patients whereas those of MO patients were elevated. Adiponectin concentrations were only lowered in MO patients. Concentrations of MCP-1, PAI-1, and IL-1 alpha were elevated in both CRC and MO patients, while resistin and TNF-alpha were similarly expressed in MO and CRC patients compared to BD. Resistin concentrations positively correlated with tumor staging (p<0.002) and grading (p=0.015) of rectal tumor patients.
  
  
  CONCLUSIONS
  The results suggest that both MO and CRC have low-grade inflammation as part of their etiology.
authors.affiliation: Department of General and Visceral Surgery, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany. Andreas.Hillenbrand@uniklinik-ulm.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Hillenbrand
authors.forename: Juliane
authors.initials: J
authors.lastname: Fassler
authors.forename: Nadine
authors.initials: N
authors.lastname: Huber
authors.forename: Pengfei
authors.initials: P
authors.lastname: Xu
authors.forename: Doris
authors.initials: D
authors.lastname: Henne-Bruns
authors.forename: Markus
authors.initials: M
authors.lastname: Templin
authors.forename: Hubert
authors.initials: H
authors.lastname: Schrezenmeier
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Wolf
authors.forename: Uwe
authors.initials: U
authors.lastname: Knippschild
mesh_terms: D054392:Adipokines / Q000097:blood* / Q000378:metabolism*; D052242:Adiponectin / Q000097:blood / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D018932:Chemokine CCL2 / Q000097:blood / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000097:blood* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000378:metabolism / Q000473:pathology; D053582:Interleukin-1alpha / Q000097:blood / Q000378:metabolism; D020738:Leptin / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000378:metabolism* / Q000473:pathology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000378:metabolism; D052243:Resistin / Q000097:blood / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism; D055815:Young Adult
chemical_list: D054392:Adipokines; D052242:Adiponectin; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D053582:Interleukin-1alpha; D020738:Leptin; D017395:Plasminogen Activator Inhibitor 1; D052243:Resistin; C051321:SERPINE1 protein, human; D014409:Tumor Necrosis Factor-alpha