title: Modified repeated intracyclic clomiphene citrate therapy after conventional clomiphene therapy.
abstract: OBJECTIVE
  We compared modified repeated intracyclic clomiphene citrate therapy (RICCT) to gonadotropin therapy to determine whether this modified regimen was an effective alternative after conventional clomiphene therapy.
  
  
  METHODS
  Patients with ovulation disorder received treatment with modified RICCT and gonadotropin, and ovulation, pregnancy, total drug cost, and adverse effects were compared.
  
  
  RESULTS
  Among a total of 16 patients, 14 successfully ovulated after modified RICCT and 11 ovulated after gonadotropin therapy; two did not respond to either therapy. The total drug cost was US $36.3+/-17.9 for modified RICCT, which was significantly lower than the cost of gonadotropin therapy, US $213.9+/-100.4 (p=0.0001).
  
  
  CONCLUSIONS
  Because modified RICCT does not require the discomfort of daily injection and has excellent ovulation-inducing effects, it is a useful treatment after conventional clomiphene therapy.
authors.affiliation: Department of Obstetrics and Gynecology, Kohseichuo General Hospital, Tokyo, Japan. mkawamura@kohseichuo.jp
authors.forename: M
authors.initials: M
authors.lastname: Kawamura
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: R
authors.initials: R
authors.lastname: Kanda
authors.forename: H
authors.initials: H
authors.lastname: Kiseki
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukahara
authors.forename: N
authors.initials: N
authors.lastname: Hashimura
mesh_terms: D002996:Clomiphene / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics; D016527:Drug Costs; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D006062:Gonadotropins / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female; D008596:Menotropins / Q000008:administration & dosage; D010062:Ovulation Induction / Q000191:economics / Q000379:methods*; D011247:Pregnancy
chemical_list: D005300:Fertility Agents, Female; D006062:Gonadotropins; D002996:Clomiphene; D008596:Menotropins