title: Primary malignant melanoma of the esophagus with extensive intraepithelial extension.
abstract: Primary malignant melanoma of the esophagus (PMME) is an exceedingly rare tumor. The prognosis of PMME is very poor, and the 5-year survival rate is only 2.2% due to its aggressive biologic character. We present patient with PMME with wide extension into almost the entire esophagus, without endoscopic abnormalities. This patient's presentation is extremely valuable because it has enabled us to observe the long-term natural progression of PMME, including recurrent disease with a wide range of atypical melanocytic cells in the entire esophagus.
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, and Department of Surgical Pathology, Kumamoto University Hospital, Kumamoto, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Inadomi
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Ishimoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Watanabe
authors.forename: Masaaki
authors.initials: M
authors.lastname: Iwatsuki
authors.forename: Kota
authors.initials: K
authors.lastname: Arima
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ida
authors.forename: Yohei
authors.initials: Y
authors.lastname: Nagai
authors.forename: Shiro
authors.initials: S
authors.lastname: Iwagami
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Baba
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Yumi
authors.initials: Y
authors.lastname: Honda
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Iyama
authors.forename: Hideo
authors.initials: H
authors.lastname: Baba
mesh_terms: D003937:Diagnosis, Differential; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D016629:Esophagectomy / Q000379:methods*; D004945:Esophagoscopy; D005500:Follow-Up Studies; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness