title: A study of serum biomarkers associated with relapse of cervical cancer.
abstract: OBJECTIVE
  To discover candidate protein biomarkers in the serum of patients with cervical cancer that differentiate between patients with relapse from those who are tumor-free after primary treatment with (platinum-based chemo-) radiation.
  
  
  METHODS
  Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) with cation exchange (CM10) and hydrophobic/reverse-phase (H50) was used to examine 44 serum samples from patients with advanced cervical cancer, primarily treated with (platinum-based chemo-) radiation.
  
  
  RESULTS
  Ten candidate biomarkers were identified in the serum of 34 patients. Six candidate markers were elevated in patients with no relapse and four were elevated in patients with relapse [p=0.007-0.11; area under the curve (AUC)=0.70-0.75]. Masses of candidate biomarkers ranged from 2,022 to 116,165 Da.
  
  
  CONCLUSIONS
  Patients with relapse from primary advanced cervical cancer exhibit different serum protein expression profiles from those with no relapse.
authors.affiliation: Department of Oncology, Örebro University Hospital, SE-701 85 Örebro, Sweden. louise.bohr-mordhorst@orebroll.se
authors.forename: Louise Bohr
authors.initials: LB
authors.lastname: Mordhorst
authors.forename: Bengt
authors.initials: B
authors.lastname: Sorbe
authors.forename: Cecilia
authors.initials: C
authors.lastname: Ahlin
mesh_terms: D000368:Aged; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000473:pathology*; D009367:Neoplasm Staging; D040081:Protein Array Analysis; D012372:ROC Curve; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor