title: Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias.
abstract: The Wnt-responsive transcription factors Tcf1 and Lef1 are well-known for their roles in lymphocyte development. In this issue of Immunity, Yu et al. (2012) report that Tcf1-deficient mice develop aggressive T cell lymphomas that are characterized by high Lef1 expression.
authors.affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. f.j.t.staal@lumc.nl
authors.forename: Frank J T
authors.initials: FJ
authors.lastname: Staal
authors.forename: Hans
authors.initials: H
authors.lastname: Clevers