title: Non-MHC genes linked to autoimmune disease.
abstract: The genetic traits that result in autoimmune diseases represent complicating factors in explicating the molecular and cellular elements of autoimmune responses and how these responses can be overcome or manipulated. This article focuses on the major non-major histocompatibility complex genes that have been found to be linked to autoimmune diseases. A given gene may associate with a number of autoimmune diseases and, conversely, a given disease may link to a number of common autoimmune disease (AD) genes. Collaboration and interaction among genes and the number of diseases that develop and the extensive risk factors shared among ADs further complicate the outcome. This article describes the various relationships between gene regions associated with multiple ADs and the complexity of those relationships.
authors.affiliation: Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. pdeitik@bcm.edu
authors.forename: Philip
authors.initials: P
authors.lastname: Deitiker
authors.forename: M Zouhair
authors.initials: MZ
authors.lastname: Atassi
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D053263:Gene Regulatory Networks / Q000276:immunology; D059647:Gene-Environment Interaction; D005819:Genetic Markers / Q000276:immunology; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000639:trends; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D020412:Multifactorial Inheritance / Q000276:immunology; D010375:Pedigree; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000276:immunology
chemical_list: D005819:Genetic Markers; D014409:Tumor Necrosis Factor-alpha