title: Xenobiotic sulphation and its variability during inflammation: a factor in adverse drug reactions?
abstract: The interactions between disease processes and the metabolism of therapeutic drugs have not been systematically investigated. Inflammation, with the presence of pro-inflammatory cytokines, affects Phase 1 metabolism, particularly the activity of the CYP isoforms. Inflammatory factors also alter the activity of some Phase 2 enzymes, particularly the sulphotransferases (SULT isoforms) responsible for drug sulphonation and the enzyme pathway involved in the supply of sulphate for this reaction. Being ill may, therefore, in itself make drug metabolism unpredictable.
authors.affiliation: Centre for Toxicology, School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK. R.H.WARING@bham.ac.uk
authors.forename: R H
authors.initials: RH
authors.lastname: Waring
authors.forename: R M
authors.initials: RM
authors.lastname: Harris
authors.forename: J O
authors.initials: JO
authors.lastname: Hunter
authors.forename: S C
authors.initials: SC
authors.lastname: Mitchell
mesh_terms: D000818:Animals; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism; D013431:Sulfates / Q000378:metabolism*; D015262:Xenobiotics / Q000009:adverse effects / Q000493:pharmacokinetics*
chemical_list: D004364:Pharmaceutical Preparations; D013431:Sulfates; D015262:Xenobiotics