title: Tributyltin exposure causes lipotoxicity responses in the ovaries of rockfish, Sebastiscus marmoratus.
abstract: Tributyltin (TBT) is a well-studied endocrine disruptor in mollusks and fishes. Recently, TBT is also recognized as a metabolic disruptor. Since abnormal lipids metabolism can induce negative effects on reproduction, the present study was designed to investigate the effects of TBT on ovarian lipid accumulation and testosterone esterification in rockfish (Sebastiscus marmoratus). After exposure for 48 d, there was a decrease of neutral lipid droplets in the ooplasm of ovaries. Exposure has also induced lipotoxicity responses in the ovaries, which shown as an increase of interstitial ectopic lipid accumulation and total lipids. The decrease of serum triiodothyronine and thyroxine concentrations might be responsible for the lipotoxicity responses. In addition, the percentage of testosterone in an esterified form was significantly decreased in the ovaries by TBT exposure, which might be a mechanism by which free testosterone levels increased. The accumulation of ectopic lipids and increase of free testosterone levels in the ovaries might impact ovarian functions and oocyte development in fish. These results strongly indicate that TBT exposure can influence reproductive functions of rockfish through lipotoxic mechanism.
authors.affiliation: College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, PR China.
authors.forename: Jiliang
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Zuo
authors.forename: Jianli
authors.initials: J
authors.lastname: Xiong
authors.forename: Ping
authors.initials: P
authors.lastname: Sun
authors.forename: Yixin
authors.initials: Y
authors.lastname: Chen
authors.forename: Chonggang
authors.initials: C
authors.lastname: Wang
mesh_terms: D000818:Animals; D052244:Endocrine Disruptors / Q000633:toxicity*; D005260:Female; D005399:Fishes / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000032:analysis; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D052244:Endocrine Disruptors; D008055:Lipids; D014220:Trialkyltin Compounds; D014874:Water Pollutants, Chemical; D013739:Testosterone; C011559:tributyltin