title: Two new compounds from Hicriopteris glauca and their potential antitumor activities.
abstract: Chemical examination of the EtOAc extract from the stems of Hicriopteris glauca (Thunb) Ching. led to the isolation of two new compounds: lunularic acid 4'-glucoside and 2,9-dihydroxy-4,7-megastigmadiene-3-O-β-glucoside. Their structures were elucidated on the basis of spectral analysis and by comparing their spectral data with those in literature. Two compounds, along with the petroleum ether, chloroform, EtOAc, and n-BuOH extracts, were tested for cytotoxic activities. Only the n-BuOH extract showed antitumor activity against human melanoma A375 cells with IC₅₀ values of 0.80 μg/ml.
authors.affiliation: Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Fang
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.forename: Shuang
authors.initials: S
authors.lastname: Liang
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Ke-Feng
authors.initials: KF
authors.lastname: Ruan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029624:Ferns / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: C578233:2,9-dihydroxy-4,7-megastigmadiene-3-O-beta-glucoside; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D010936:Plant Extracts; C578232:lunularic acid 4'-glucoside