title: Injecting epidural and intra-articular triamcinolone in HIV-positive patients on ritonavir: beware of iatrogenic Cushing's syndrome.
abstract: We report two HIV-positive patients on highly active antiretroviral therapy (HAART) who developed clinical features in keeping with secondary adrenal suppression following epidural and subacromial triamcinolone. Both patients were on ritonavir-boosted protease inhibitor containing HAART and both required maintenance hydrocortisone therapy following diagnosis. This highlights the need for radiologists and clinicians practicing these injections to be aware of this complication, to elicit an accurate drug history, and to take adequate measures to minimize these adverse effects.
authors.affiliation: Radiology Department, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, UK. mmaviki@doctors.org.uk
authors.forename: M
authors.initials: M
authors.lastname: Maviki
authors.forename: P
authors.initials: P
authors.lastname: Cowley
authors.forename: H
authors.initials: H
authors.lastname: Marmery
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects; D000075202:Contraindications; D003480:Cushing Syndrome / Q000139:chemically induced* / Q000517:prevention & control*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000008:administration & dosage; D006801:Humans; D007268:Injections, Epidural; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D019438:Ritonavir / Q000008:administration & dosage*; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D017320:HIV Protease Inhibitors; D014221:Triamcinolone; D019438:Ritonavir