title: Clerodendranoic acid, a new phenolic acid from Clerodendranthus spicatus.
abstract: Phenolic acid derivatives are typical constituents of Clerodendranthus spicatus which were considered to the active principles of this medicinal plant. These chemical constituents with their interesting frameworks and biological significance attracted our attention. As part of our ongoing chemical investigation of C. spicatus using various column chromatography techniques, a new phenolic compound, named clerodendranoic acid (1), was isolated from the aerial parts of C. spicatus together with five known ones, including rosmarinic acid (2), methyl rosmarinate (3), caffeic acid (4), methyl caffeate (5), ethyl caffeate (6). Their structures, including stereochemical configurations, were completely established by extensive spectroscopic methods, mainly inclvolving 1D, 2D NMR, as well as HRESIMS.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
authors.forename: Qingxia
authors.initials: Q
authors.lastname: Zheng
authors.forename: Zhaocui
authors.initials: Z
authors.lastname: Sun
authors.forename: Xiaopo
authors.initials: X
authors.lastname: Zhang
authors.forename: Jinquan
authors.initials: J
authors.lastname: Yuan
authors.forename: Haifeng
authors.initials: H
authors.lastname: Wu
authors.forename: Junshan
authors.initials: J
authors.lastname: Yang
authors.forename: Xudong
authors.initials: X
authors.lastname: Xu
mesh_terms: D002934:Cinnamates / Q000737:chemistry* / Q000302:isolation & purification; D053630:Depsides; D062385:Hydroxybenzoates / Q000737:chemistry* / Q000302:isolation & purification; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D002934:Cinnamates; D053630:Depsides; D062385:Hydroxybenzoates; D010936:Plant Extracts; C000629695:rosmarinic acid methyl ester