title: Dihydroflavonol and flavonol derivatives from Macaranga recurvata.
abstract: Two new dihydroflavonol derivatives, macarecurvatins A and B, have been isolated from the leaves of Macaranga recurvata (Euphorbiaceaae), along with the known compounds diisoprenylaromadendrin, glyasperin A and broussoflavonol F. The structures of the new compounds were determined on the basis of spectroscopic evidence. Upon cytotoxic evaluation against P-388 cells, macarecurvatin B showed strong activity with an IC50 of 0.83 microM.
authors.affiliation: Chemistry Department, Airlangga University, Jalan Darmawangsa Dalam, Surabaya 60222, Indonesia.
authors.forename: Mulyadi
authors.initials: M
authors.lastname: Tanjung
authors.forename: Euis H
authors.initials: EH
authors.lastname: Hakim
authors.lastname: Elfahmi
authors.forename: Jalifa
authors.initials: J
authors.lastname: Latip
authors.forename: Yana M
authors.initials: YM
authors.lastname: Syah
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D019665:Euphorbiaceae / Q000737:chemistry*; D044948:Flavonols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044948:Flavonols; C576780:macarecurvatin A; C576779:macarecurvatin B