title: Identifying and quantifying misclassified and under-reported AIDS deaths in Brazil: a retrospective analysis from 1985 to 2009.
abstract: BACKGROUND
  A retrospective analysis of deaths registered in the Brazilian Mortality System was conducted to quantify the under-reporting of HIV/AIDS deaths and those misclassified to AIDS-related conditions in the 15-49 years old population in Brazil.
  
  
  METHODS
  Death rates for AIDS-related diseases were calculated by age and sex for 1985-2009. Changes in the age-sex-specific death rates over time were used to identify conditions likely to be misclassified AIDS deaths and to quantify the corresponding number of misclassified deaths. Deaths due to ill-defined causes were redistributed across all other natural causes of death. The resulting total number of AIDS deaths was further adjusted for incompleteness of the mortality reporting system.
  
  
  RESULTS
  Out of the 28 potential causes of death investigated, five increased in the same distinct age pattern as AIDS: pneumonia, Kaposi's sarcoma, other immunodeficiencies, other septicaemia and toxoplasmosis. 18 490 deaths due to these five causes were recoded to HIV/AIDS from 1985 to 2009. 38 145 deaths due to ill-defined causes were redistributed to AIDS and 15 485 were added to the number of AIDS deaths to correct for completeness of the mortality system in Brazil. Altogether, 72 120 deaths were recoded to AIDS between 1985 and 2009 and added to the reported 194 445 AIDS related deaths in the country, representing 27% misclassification of AIDS deaths in Brazil.
  
  
  CONCLUSIONS
  This study demonstrated that AIDS mortality is underestimated by the official mortality information system in Brazil. Efforts need to be made to reduce misclassification of causes of death in the future and identify ways in which the confidentiality of information regarding cause of death can be maintained.
authors.affiliation: Faculty of Health Sciences, University of Brasília, Brazil. erikafazito@gmail.com
authors.forename: Erika
authors.initials: E
authors.lastname: Fazito
authors.forename: Paloma
authors.initials: P
authors.lastname: Cuchi
authors.forename: Doris Ma
authors.initials: DM
authors.lastname: Fat
authors.forename: Peter Denis
authors.initials: PD
authors.lastname: Ghys
authors.forename: Mauricio G
authors.initials: MG
authors.lastname: Pereira
authors.forename: Ana Maria Nogales
authors.initials: AM
authors.lastname: Vasconcelos
authors.forename: Ana Roberta Pati
authors.initials: AR
authors.lastname: Pascom
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology* / Q000401:mortality*; D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D004812:Epidemiologic Methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult