title: Association of low maternal levels of salusins with gestational diabetes mellitus and with small-for-gestational-age fetuses.
abstract: OBJECTIVE
  To evaluate maternal and cord serum concentrations of salusin-α and salusin-β in women with gestational diabetes mellitus (GDM) and with small-for-gestational age (SGA) fetuses.
  
  
  METHODS
  Pregnant women with GDM (n=25), women with SGA (n=20) and maternal age-matched normal healthy pregnant subjects (n=25) participated in the study. Maternal serum and cord blood salusin-α and salusin-β levels at the time of birth were measured using ELISA, and their relation with metabolic parameters was also assessed.
  
  
  RESULTS
  Mean concentrations of maternal and fetal serum salusin-α in the GDM and SGA groups were significantly lower than those of the controls (P<0.001, P<0.001, P<0.001 and P<0.001, respectively). Mean concentrations of maternal and cord blood salusin-β also decreased in both the GDM and the SGA groups in comparison to the control group (P<0.001, P<0.001, P<0.001 and P<0.001, respectively). The concentrations of maternal serum salusin-α and salusin-β were strongly positively correlated with the concentrations of cord blood salusin-α and salusin-β (R=0.92, P<0.001 and R=0.94, P<0.001, respectively).
  
  
  CONCLUSIONS
  The low levels of maternal serum salusin-α and salusin-β may have negative impact on metabolic disorders and vascular dysfunction.
authors.affiliation: Department of Obstetrics and Gynecology, Inonu University School of Medicine, Malatya, Turkey. ecelik05@googlemail.com
authors.forename: Ebru
authors.initials: E
authors.lastname: Celik
authors.forename: Onder
authors.initials: O
authors.lastname: Celik
authors.forename: Ercan
authors.initials: E
authors.lastname: Yilmaz
authors.forename: Ilgin
authors.initials: I
authors.lastname: Turkcuoglu
authors.forename: Abdullah
authors.initials: A
authors.lastname: Karaer
authors.forename: Ugur
authors.initials: U
authors.lastname: Turhan
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
mesh_terms: D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D002585:Cesarean Section; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005312:Fetal Blood; D005865:Gestational Age; D006706:Homeostasis; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood*; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D011247:Pregnancy; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D036341:Intercellular Signaling Peptides and Proteins; C478739:TOR2A protein, human