title: [Family occurrence of steroid-sensitive idiopathic nephrotic syndrome].
abstract: Nephrotic syndrome (NS) presented within three weeks in siblings aged six and ten years. Both children experienced proteinuria, hypoalbuminaemia and oedema, with the most pronounced symptoms in the older. Standard treatment with prednisolone led to remission of the nephrotic syndrome in the younger, whereas the older required additional therapy with tacrolismus before remission. In view of the low incidence of NS in children, a near simultaneously onset in two siblings must lead to genetic elucidation. Genetic disorders and other causes of childhood NS are discussed.
authors.affiliation: Børneafdelingen, Regionshospitalet Viborg, Heibergs Alle 4, Viborg. tusgaard@dadlnet.dk
authors.forename: Birgitte
authors.initials: B
authors.lastname: Tusgaard Petersen
authors.forename: Rene
authors.initials: R
authors.lastname: Frydensbjerg Andersen
authors.forename: Søren
authors.initials: S
authors.lastname: Rittig
mesh_terms: D001706:Biopsy; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D007668:Kidney / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D009154:Mutation; D009402:Nephrosis, Lipoid / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics*; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics*; D011239:Prednisolone / Q000627:therapeutic use*; D016559:Tacrolimus / Q000627:therapeutic use; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C407223:NPHS2 protein; D011239:Prednisolone; D016559:Tacrolimus