title: Two-stage amplification of receptors using a multilevel orthogonal/simultaneous dynamic combinatorial library.
abstract: Sequential activation of different reversible exchange reactions in a dynamic combinatorial library allows directed exploration of the chemical space: initially a macrocyclic scaffold is selected by the template and finally side chain and conformational constrains are introduced into such a scaffold.
authors.affiliation: Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Escalante
authors.forename: A Gastón
authors.initials: AG
authors.lastname: Orrillo
authors.forename: Ignacio
authors.initials: I
authors.lastname: Cabezudo
authors.forename: Ricardo L E
authors.initials: RL
authors.lastname: Furlan
mesh_terms: D020650:Combinatorial Chemistry Techniques; D006835:Hydrazones / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D013457:Sulfur Compounds / Q000737:chemistry*
chemical_list: D006835:Hydrazones; D047028:Macrocyclic Compounds; D013457:Sulfur Compounds