title: Gastroesophageal reflux disease with laryngopharyngeal manifestation in Korea.
abstract: OBJECTIVE
  Globus pharyngeus and hoarseness are common extraesophageal manifestations inpatients with gastroesophageal reflux disease. The aim of this study was to evaluate the clinical characteristics, laryngoscopic findings, endoscopic findings, and response to proton pump inhibitors in patients presenting laryngeal symptoms suspected to be caused by GERD.
  
  
  METHODS
  We retrospectively reviewed the medical records of 160 patients that presented with globus and/or hoarseness and underwent acid suppression therapy under the impression of GERDfrom May 2003 to April 2009.
  
  
  RESULTS
  Sixty patients(37.5%) reported classical GERD symptoms such as heartburn and/or acid regurgitation. Sixty nine percent(69%) of patients (95/138) showed abnormal laryngoscopic findings such as laryngeal edema/hyperemia, vocal cord swelling/hyperemia, arytenoids swelling/hyperemia, vocal cord nodule, vocal cord polyp, post-glottic swelling/hyperemia, etc. Endoscopically, 41.9%(39/93) showed normal endoscopic findings and 49.5% (46/93) showed minimal changes. 8.6% (8/93)of patients showed erosive reflux disease. Therapeutic response was not significantly different among patients treated with standard dose PPIs (44/58, 75.9%),half dose PPIs (17/22, 77.3%), or revaprazan (18/21,85.7%).
  
  
  CONCLUSIONS
  Among patients with globus pharyngeus and/or hoarseness and suspected GERD, only 37.5% reported classical symptoms of GERD such as heartburn and/or acid regurgitation, 69% showed ab-normal laryngoscopic findings, 58.1% showed abnormal endoscopic findings, and 80% showed therapeutic response to acid suppression therapy.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Ju Hee
authors.initials: JH
authors.lastname: Park
authors.forename: Dong Ho
authors.initials: DH
authors.lastname: Lee
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: So Youn
authors.initials: SY
authors.lastname: Park
authors.forename: Hyuk
authors.initials: H
authors.lastname: Yoon
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Park
authors.forename: Nayoung
authors.initials: N
authors.lastname: Kim
authors.forename: Sook-Hyang
authors.initials: SH
authors.lastname: Jeong
authors.forename: Jin-Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Sang Hyub
authors.initials: SH
authors.lastname: Lee
authors.forename: Jin Hyeok
authors.initials: JH
authors.lastname: Hwang
authors.forename: Hyun Chae
authors.initials: HC
authors.lastname: Jung
mesh_terms: D000328:Adult; D000368:Aged; D003680:Deglutition Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D004942:Esophagitis, Peptic / Q000453:epidemiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006356:Heartburn / Q000453:epidemiology; D006685:Hoarseness / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D054328:Proton Pump Inhibitors / Q000008:administration & dosage; D011744:Pyrimidinones / Q000008:administration & dosage; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D044005:Tetrahydroisoquinolines / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors; D011744:Pyrimidinones; D044005:Tetrahydroisoquinolines; C108798:YH 1885