title: First-trimester metabolomic detection of late-onset preeclampsia.
abstract: OBJECTIVE
  We sought to identify first-trimester maternal serum biomarkers for the prediction of late-onset preeclampsia (PE) using metabolomic analysis.
  
  
  METHODS
  In a case-control study, nuclear magnetic resonance-based metabolomic analysis was performed on first-trimester maternal serum between 11(+0)-13(+6) weeks of gestation. There were 30 cases of late-onset PE, i.e., requiring delivery ≥37 weeks, and 59 unaffected controls. The concentrations of 40 metabolites were compared between the 2 groups. We also compared 30 early-onset cases to the late-onset group.
  
  
  RESULTS
  A total of 14 metabolites were significantly elevated and 3 significantly reduced in first-trimester serum of late-onset PE patients. A complex model consisting of multiple metabolites and maternal demographic characteristics had a 76.6% sensitivity at 100% specificity for PE detection. A simplified model using fewer predictors yielded 60% sensitivity at 96.6% specificity. Strong separation of late- vs early-onset PE groups was achieved.
  
  
  CONCLUSIONS
  Significant differences in the first-trimester metabolites were noted in women who went on to developed late-onset PE and between early- and late-onset PE.
authors.affiliation: Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
authors.forename: Ray O
authors.initials: RO
authors.lastname: Bahado-Singh
authors.forename: Ranjit
authors.initials: R
authors.lastname: Akolekar
authors.forename: Rupasri
authors.initials: R
authors.lastname: Mandal
authors.forename: Edison
authors.initials: E
authors.lastname: Dong
authors.forename: Jianguo
authors.initials: J
authors.lastname: Xia
authors.forename: Michael
authors.initials: M
authors.lastname: Kruger
authors.forename: David S
authors.initials: DS
authors.lastname: Wishart
authors.forename: Kypros
authors.initials: K
authors.lastname: Nicolaides
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D055432:Metabolomics; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011446:Prospective Studies
chemical_list: D015415:Biomarkers