title: [Effect of house dust mite vaccine on pulmonary function and inhaled corticosteroid doses in children with allergic asthma].
abstract: OBJECTIVE
  To observe the dynamic changes of pulmonary function and inhaled corticosteroid (ICS) doses during subcutaneous immunotherapy (SCIT) with standardized house dust mite vaccine (Alutard) in children with mild to moderate allergic asthma.
  
  
  METHODS
  One hundred children with mild to moderate allergic asthma were randomized into SCIT group and control group for treatment with SCIT plus ICS and with ICS only, respectively. The pulmonary function and ICS doses were evaluated before and every 3 months during the 2 years of treatment.
  
  
  RESULTS
  No significant difference was found in the pulmonary functions between the two groups before the treatment (P>0.05). After 3 months of treatment, FEV1% and PEF% in SCIT group were significantly higher than those in the control group [(103.19∓2.07)% vs (97.52∓1.92)%, and (105.56∓3.21)% vs (96.35∓2.7)%, respectively]; at 21 months, FEF50% and FEF25% were significantly higher in SCIT group than in the control group [(105.69∓3.29)% vs (94.61∓3.12)%, and (106.60∓3.71)% vs (92.92∓3.31)%, respectively]. A significant difference was found in ICS doses between SCIT group and the control group after 9 months of treatment (147.14∓6.41 vs 170∓4.95 µg/day, P<0.05), and the difference increased as the treatment prolonged.
  
  
  CONCLUSIONS
  SCIT combined with ICS can improve the ventilation function of the large airways early after the commencement of treatment, but its effect on small airways can be delayed. SCIT for 2 years shows a good therapeutic effect and can reduce the doses of ICS in children with mild to moderate allergic asthma.
authors.affiliation: Department of Respiratory Medicine, Chongqing Medical University, Chongqing, China. yeyu19870313@126.com
authors.forename: Zehui
authors.initials: Z
authors.lastname: Ye
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Caihui
authors.initials: C
authors.lastname: Gong
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000485:Allergens / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D002648:Child; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008297:Male; D039981:Pyroglyphidae / Q000276:immunology; D012129:Respiratory Function Tests; D016896:Treatment Outcome; D014612:Vaccines / Q000627:therapeutic use*
chemical_list: D000305:Adrenal Cortex Hormones; D000485:Allergens; D014612:Vaccines