title: Applications of helical-chiral pyridines as organocatalysts in asymmetric synthesis.
abstract: A new family of chiral pyridines has been designed and synthesized for use in asymmetric organocatalysis. Thus, helical-chiral pyridines induce high enantioselectivity in a range of mechanistically unrelated, synthetically significant transformations, including Friedel-Crafts alkylation with nitroalkenes, periselective Diels-Alder reactions with nitroalkenes, the ring-opening of epoxides with a chloride nucleophile, and the propargylation of aldehydes.
authors.affiliation: Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, Florida 33146-0431, USA.
authors.forename: Zhili
authors.initials: Z
authors.lastname: Peng
authors.forename: Norito
authors.initials: N
authors.lastname: Takenaka