title: Leucocytosis and thrombosis at diagnosis are associated with poor survival in polycythaemia vera: a population-based study of 327 patients.
abstract: Three hundred and twenty-seven patients from two population-based cohorts with an established diagnosis of polycythaemia vera were studied for prognostic risk factors for survival and leukaemia in a long-term survey. The relative survival (RS) was 72% and 46% at 10 and 20 years respectively, from the time of diagnosis. Multivariate analysis identified age >70 years, white blood cell count >13 × 10(9) /l and thrombo-embolism at diagnosis as independent risk factors. Patients with two or three of these factors had a 10 year RS of 26%, compared with 59% and 84% in patients with one and no risk factors, respectively. Age and leucocyte count are the main predicting factors for survival in polycythaemia vera.
authors.affiliation: Service d'Hématologie Biologique, CHU de Dijon, Dijon, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Bonicelli
authors.forename: Khadija
authors.initials: K
authors.lastname: Abdulkarim
authors.forename: Morgane
authors.initials: M
authors.lastname: Mounier
authors.forename: Peter
authors.initials: P
authors.lastname: Johansson
authors.forename: Cédric
authors.initials: C
authors.lastname: Rossi
authors.forename: Valérie
authors.initials: V
authors.lastname: Jooste
authors.forename: Björn
authors.initials: B
authors.lastname: Andreasson
authors.forename: Marc
authors.initials: M
authors.lastname: Maynadié
authors.forename: François
authors.initials: F
authors.lastname: Girodon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006333:Heart Failure / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000401:mortality; D007958:Leukocyte Count; D007964:Leukocytosis / Q000209:etiology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality; D011087:Polycythemia Vera / Q000097:blood / Q000401:mortality*; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D013927:Thrombosis / Q000209:etiology / Q000401:mortality*; D055815:Young Adult