title: CXCR7 receptors facilitate the progression of colon carcinoma within lung not within liver.
abstract: BACKGROUND
  Liver and lung metastases are the predominant cause of colorectal cancer (CRC)-related mortality. Chemokine-receptor pairs have a critical role in determining the metastatic progression of tumours. Our hypothesis was that disruption of CXCR7/CXCR7 ligands axis could lead to a decrease in CRC metastases.
  
  
  METHODS
  Primary tumours and metastatic tissues from patients with CRC were tested for the expression of CXCR7 and its ligands. Relevance of CXCR7/CXCR7 ligands for CRC metastasis was then investigated in mice using small pharmacological CXCR7 antagonists and CRC cell lines of human and murine origins, which - injected into mice - enable the development of lung and liver metastases.
  
  
  RESULTS
  Following injection of CRC cells, mice treated daily with CXCR7 antagonists exhibited a significant reduction in lung metastases. However, CXCR7 antagonists failed to reduce the extent of liver metastasis. Moreover, there were subtle differences in the expression of CXCR7 and its ligands between lung and liver metastases.
  
  
  CONCLUSIONS
  Our study suggests that the activation of CXCR7 on tumour blood vessels by its ligands may facilitate the progression of CRC within lung but not within liver. Moreover, we provide evidence that targeting the CXCR7 axis may be beneficial to limit metastasis from colon cancer within the lungs.
authors.affiliation: Université de Nice Sophia-Antipolis, UFR Sciences, Nice 06108, France.
authors.forename: E
authors.initials: E
authors.lastname: Guillemot
authors.forename: B
authors.initials: B
authors.lastname: Karimdjee-Soilihi
authors.forename: E
authors.initials: E
authors.lastname: Pradelli
authors.forename: M
authors.initials: M
authors.lastname: Benchetrit
authors.forename: E
authors.initials: E
authors.lastname: Goguet-Surmenian
authors.forename: M-A
authors.initials: MA
authors.lastname: Millet
authors.forename: F
authors.initials: F
authors.lastname: Larbret
authors.forename: J-F
authors.initials: JF
authors.lastname: Michiels
authors.forename: D
authors.initials: D
authors.lastname: Birnbaum
authors.forename: P
authors.initials: P
authors.lastname: Alemanno
authors.forename: H
authors.initials: H
authors.lastname: Schmid-Antomarchi
authors.forename: A
authors.initials: A
authors.lastname: Schmid-Alliana
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002277:Carcinoma / Q000378:metabolism* / Q000556:secondary*; D045744:Cell Line, Tumor; D054377:Chemokine CXCL12 / Q000378:metabolism; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D016209:Interleukin-8 / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary; D008175:Lung Neoplasms / Q000378:metabolism* / Q000556:secondary*; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D060888:Real-Time Polymerase Chain Reaction; D054387:Receptors, CXCR / Q000037:antagonists & inhibitors / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D054377:Chemokine CXCL12; C501897:Cmkor1 protein, mouse; D016209:Interleukin-8; D054387:Receptors, CXCR; D042461:Vascular Endothelial Growth Factor A