title: Intensification of peritoneal dialysis improves valacyclovir neurotoxicity.
abstract: Valacyclovir induced neurotoxicity is a life-threatening complication, usually starting 24-48 h after drug-peak serum concentrations. The elderly with impaired renal function seem to be the most susceptible group to valacyclovir neurotoxicity. Although hemodialysis is considered the best method for rapid drug removal, our case showed that intensive peritoneal dialysis regimen leads to the recovery of neurotoxicity after 3 days.
authors.affiliation: Department of Nephrology, Aretaieion University Hospital, Athens, Greece. chrysapi2001@gmail.com
authors.forename: Chrysoula
authors.initials: C
authors.lastname: Pipili
authors.forename: Kostas
authors.initials: K
authors.lastname: Pantelias
authors.forename: Edmond
authors.initials: E
authors.lastname: Deda
authors.forename: Pandelis
authors.initials: P
authors.lastname: Tsiamalos
authors.forename: Evaggelos
authors.initials: E
authors.lastname: Kostis
authors.forename: Eirini
authors.initials: E
authors.lastname: Grapsa
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy*; D000212:Acyclovir / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006562:Herpes Zoster / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000628:therapy; D007677:Kidney Function Tests; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods*; D018570:Risk Assessment; D016896:Treatment Outcome; D000077483:Valacyclovir; D014633:Valine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir