title: Synthesis, structural characterization and in vitro cytotoxicity of diorganotin (IV) diimido complexes.
abstract: Reactions of the diorganotin with two N-OH diimide ligands (N-hydroxyphthalimide and N-hydroxysuccinimide) yielded five new dimeric tetraorganostannoxanes formulated as R(8)Sn(4)O(2)L(2)X(2). The crystal structures of the complexes reveal the formation of the tetranuclear species contains a planar Sn(4)O(4) core, consisting of three adjacent rhombs with bridging oxo and N-OH diimide ligands. The central tin atoms are five-coordinated to assume a distorted trigonal bipyramidal configuration and the N-OH diimide ligands act as monodentate O-bound planar. In vitro cytotoxic activities of the title compounds have been determined against three cell lines (A549, HCT-8 and HL-60). Studies reveal that three di-n-butyltin(IV) diimido complexes show higher cytotoxic activities than cisplatin. The structure-activity relationship of the cytotoxicity of the title complexes has also been discussed.
authors.affiliation: Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, 1 Hunan Road, Liaocheng 252059, PR China. Electronic address: handongyin@163.com.
authors.forename: Handong
authors.initials: H
authors.lastname: Yin
authors.forename: Caihong
authors.initials: C
authors.lastname: Yue
authors.forename: Min
authors.initials: M
authors.lastname: Hong
authors.forename: Jichun
authors.initials: J
authors.lastname: Cui
authors.forename: Qingkun
authors.initials: Q
authors.lastname: Wu
authors.forename: Xiuyun
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D007094:Imides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007094:Imides; D009947:Organotin Compounds