title: Monocyte-suppressing effects of simvastatin in patients with isolated hypertriglyceridemia.
abstract: BACKGROUND
  No previous study investigated statin action on monocyte cytokine release and systemic inflammation in patients with isolated hypertriglyceridemia.
  
  
  METHODS
  Our study included 43 subjects with isolated hypertriglyceridemia and peripheral artery stenosis randomly allocated to one of two groups, treated for 12 weeks with either simvastatin (40 mg twice daily) or placebo. Plasma lipids, glucose homeostasis markers, plasma C-reactive protein and monocyte cytokine release were determined on the day of allocation and at the end of the treatment period.
  
  
  RESULTS
  Simvastatin, but not placebo, reduced monocyte release of tumor necrosis factor-α, interleukin-6, interleukin-1β and monocyte chemoattractant protein-1, as well decreased plasma levels of C-reactive protein.
  
  
  CONCLUSIONS
  Our study shows that simvastatin reduces monocyte secretory function and has systemic anti-inflammatory properties in patients with isolated hypertriglyceridemia.
authors.affiliation: Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medykow 18, Katowice, Poland. r.krysiak@interia.pl
authors.forename: Robert
authors.initials: R
authors.lastname: Krysiak
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Okopien
mesh_terms: D000328:Adult; D001682:Biological Availability; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D002468:Cell Physiological Phenomena / Q000187:drug effects*; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000150:complications / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D007249:Inflammation / Q000097:blood* / Q000150:complications; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D058729:Peripheral Arterial Disease / Q000097:blood / Q000150:complications; D019821:Simvastatin / Q000008:administration & dosage / Q000493:pharmacokinetics; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D000960:Hypolipidemic Agents; D008055:Lipids; D002097:C-Reactive Protein; D019821:Simvastatin