title: [A case of pathologically complete response of esophageal carcinoma treated with low-dose 5-FU/CDDP as neoadjuvant chemotherapy].
abstract: The patient was a 75-year-old woman with advanced esophageal cancer and lymph-node swelling in the mediastinum(cStage RR). We administered preoperative chemotherapy(5-FU 500mg/body×10, CDDP 10mg/body×10). She received the two courses without showing any serious side effects. The primary tumor revealed remarkable improvement, but the rigidity of the esophagus wall and swelling of the lymph nodes were not resolved, and images showed that the patient exhibited a partial response to the treatment. Radical resection of the esophageal carcinoma was performed. Pathological examination of the resected specimens revealed no malignant cells in the esophagus, no metastasis of the lymph node, and the response evaluation was grade 3. The patient showed no recurrence 4 years and eleven months after the operation. In lonclusion, this rare case of esophageal carcinoma showed a pathologically complete response when treated with low-dose 5-FU/CDDP as neoadjuvant chemotherapy.
authors.affiliation: Dept. of Surgery, Kagawarousai Hospital.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Miki
authors.initials: M
authors.lastname: Kishi
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Taniguchi
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kuwata
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Watanabe
authors.forename: Keigo
authors.initials: K
authors.lastname: Kimura
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Kokudo
authors.forename: Atsushi
authors.initials: A
authors.lastname: Muraoka
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tatemoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Tsumura
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D020360:Neoadjuvant Therapy; D012074:Remission Induction; D014057:Tomography, X-Ray Computed
chemical_list: D002945:Cisplatin; D005472:Fluorouracil