title: Association of vitamin D receptor gene Cdx2 polymorphism with bone markers in Turner syndrome patients.
abstract: BACKGROUND
  Turner syndrome (TS) patients usually have low bone mineral density (BMD) and increased risk of osteoporotic fractures. We have previously demonstrated an association of bb (BsmI polymorphic site) and ff (FokI polymorphic site) vitamin D receptor (VDR) genotypes with reduced BMD in TS patients.
  
  
  OBJECTIVE
  To analyze the relationship between VDR-Cdx2 polymorphism and BMD as well as bone metabolic variables in TS patients.
  
  
  METHODS
  Fifty-five TS patients and 59 control women were studied. VDR-Cdx2 genotypes were determined using TaqMan probes in a real time thermocycler. Lumbar and femoral BMD were determined by dual-energy X-ray absorptiometry (DEXA) and serum intact parathyroid hormone, osteocalcin and beta3-CrossLaps were determined by electrochemiluminescence.
  
  
  RESULTS
  Patients with genotype GG had higher levels of both osteocalcin and beta-CrossLaps as compared to patients with genotype GA (p < 0.01 and p < 0.05, respectively).
  
  
  CONCLUSIONS
  Patients carrying genotype GG have higher levels of bone formation and resorption markers. This indicates a more active bone turnover that could impact on their future bone mineral density.
authors.affiliation: Laboratorio 'Dr. Cañas', Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: María
authors.initials: M
authors.lastname: Peralta López
authors.forename: Viviana
authors.initials: V
authors.lastname: Centeno
authors.forename: Mirta
authors.initials: M
authors.lastname: Miras
authors.forename: Liliana
authors.initials: L
authors.lastname: Silvano
authors.forename: Adriana
authors.initials: A
authors.lastname: Pérez
authors.forename: Liliana
authors.initials: L
authors.lastname: Muñoz
authors.forename: Gabriela
authors.initials: G
authors.lastname: Sobrero
authors.forename: María
authors.initials: M
authors.lastname: Ulla
authors.forename: Nori
authors.initials: N
authors.lastname: Tolosa de Talamoni
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D015519:Bone Density / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D050723:Fractures, Bone / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D011401:Promoter Regions, Genetic / Q000235:genetics; D018167:Receptors, Calcitriol / Q000235:genetics*; D014424:Turner Syndrome / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018167:Receptors, Calcitriol