title: Plants from Brazilian Cerrado with potent tyrosinase inhibitory activity.
abstract: The increased amount of melanin leads to skin disorders such as age spots, freckles, melasma and malignant melanoma. Tyrosinase is known to be the key enzyme in melanin production. Plants and their extracts are inexpensive and rich resources of active compounds that can be utilized to inhibit tyrosinase as well as can be used for the treatment of dermatological disorders associated with melanin hyperpigmentation. Using in vitro tyrosinase inhibitory activity assay, extracts from 13 plant species from Brazilian Cerrado were evaluated. The results showed that Pouteria torta and Eugenia dysenterica extracts presented potent in vitro tyrosinase inhibition compared to positive control kojic acid. Ethanol extract of Eugenia dysenterica leaves showed significant (p<0.05) tyrosinase inhibitory activity exhibiting the IC₅₀ value of 11.88 µg/mL, compared to kojic acid (IC₅₀ value of 13.14 µg/mL). Pouteria torta aqueous extract leaves also showed significant inhibitory activity with IC₅₀ value of 30.01 µg/mL. These results indicate that Pouteria torta and Eugenia dysenterica extracts and their isolated constituents are promising agents for skin-whitening or antimelanogenesis formulations.
authors.affiliation: Department of Pharmaceutical Sciences, School of Health Sciences, Campus Darcy Ribeiro, University of Brasília, Brasília, Brazil.
authors.forename: Paula Monteiro
authors.initials: PM
authors.lastname: Souza
authors.forename: Silvia Taveira
authors.initials: ST
authors.lastname: Elias
authors.forename: Luiz Alberto
authors.initials: LA
authors.lastname: Simeoni
authors.forename: José Elias
authors.initials: JE
authors.lastname: de Paula
authors.forename: Sueli Maria
authors.initials: SM
authors.lastname: Gomes
authors.forename: Eliete Neves Silva
authors.initials: EN
authors.lastname: Guerra
authors.forename: Yris Maria
authors.initials: YM
authors.lastname: Fonseca
authors.forename: Elton Clementino
authors.initials: EC
authors.lastname: Silva
authors.forename: Dâmaris
authors.initials: D
authors.lastname: Silveira
authors.forename: Pérola Oliveira
authors.initials: PO
authors.lastname: Magalhães
mesh_terms: D001938:Brazil; D017753:Ecosystem; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D017495:Hyperpigmentation / Q000188:drug therapy / Q000378:metabolism; D008543:Melanins / Q000378:metabolism; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D010944:Plants / Q000737:chemistry*; D012449:Safety
chemical_list: D004791:Enzyme Inhibitors; D008543:Melanins; D010936:Plant Extracts; D014442:Monophenol Monooxygenase