title: Carbamazepine-induced hypersensitivity syndrome in chronic schizophrenia.
abstract: Drug-induced hypersensitivity syndrome is a clinically important issue. We report a case of carbamazepine-induced hypersensitivity syndrome in a 35-year-old schizophrenia patient. This patient had no previous food or medication allergy history and presented a negative test result of HLA-B*1502 genotype. After 19 days exposure of carbamazepine, high fever up to 39.4 °C, leucopenia (1670/mm3), proteinuria and bilateral lung field infiltration were developed. These clinically significant physical conditions resolved after discontinuing carbamazepine. The importance of genetic susceptibility other than HLA-B*1502 should not be overlooked in drug-induced hypersensitivity syndrome.
authors.affiliation: Bali Psychiatric Center, Bali District, New Taipei City, Taiwan.
authors.forename: Chan-Wei
authors.initials: CW
authors.lastname: Pan
authors.forename: Chi-Hua
authors.initials: CH
authors.lastname: Yu
authors.forename: Ding-Lieh
authors.initials: DL
authors.lastname: Liao
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D018692:Antimanic Agents; D002220:Carbamazepine