title: Transmission of Multidrug-resistant Tuberculosis Confirmed by Endobronchial Ultrasound Biopsy of a Mediastinal Lymph Node and DNA Fingerprinting Analysis.
abstract: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) was recently introduced for sampling of mediastinal masses and nodes, for staging of lung cancer, and for diagnosing other benign diseases including tuberculosis (TB). However, EBUS-TBNA has not been used to date to confirm the presence of multidrug-resistant TB (MDR-TB). We here describe the diagnosis of MDR-TB of a mediastinal lymph node by EBUS biopsy. MDR-TB had been transmitted to our patient from her son who had pulmonary TB, and the diagnosis of MDR-TB was confirmed by a restriction fragment length polymorphism analysis of the IS6110 segment of Mycobacterium tuberculosis isolates. Our findings highlight the use of EBUS-TBNA in diagnosing TB, including MDR-TB, and malignancies, in a TB-endemic area.
authors.affiliation: *Division of Pulmonary and Critical Care Medicine ‡Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center †The Korean Institute of Tuberculosis, Seoul, Korea.
authors.forename: Jiwon
authors.initials: J
authors.lastname: Lyu
authors.forename: Chang Ki
authors.initials: CK
authors.lastname: Kim
authors.forename: Mi-Na
authors.initials: MN
authors.lastname: Kim
authors.forename: Chang-Min
authors.initials: CM
authors.lastname: Choi
authors.forename: Woo Sung
authors.initials: WS
authors.lastname: Kim
authors.forename: Dong Soon
authors.initials: DS
authors.lastname: Kim
authors.forename: Tae Sun
authors.initials: TS
authors.lastname: Shim