title: The impact of insecticide-treated school uniforms on dengue infections in school-aged children: study protocol for a randomised controlled trial in Thailand.
abstract: BACKGROUND
  There is an urgent need to protect children against dengue since this age group is particularly sensitive to the disease. Since dengue vectors are active mainly during the day, a potential target for control should be schools where children spend a considerable amount of their day. School uniforms are the cultural norm in most developing countries, worn throughout the day. We hypothesise that insecticide-treated school uniforms will reduce the incidence of dengue infection in school-aged children. Our objective is to determine the impact of impregnated school uniforms on dengue incidence.
  
  
  METHODS
  A randomised controlled trial will be conducted in eastern Thailand in a group of schools with approximately 2,000 students aged 7-18 years. Pre-fabricated school uniforms will be commercially treated to ensure consistent, high-quality insecticide impregnation with permethrin. A double-blind, randomised, crossover trial at the school level will cover two dengue transmission seasons.
  
  
  CONCLUSIONS
  Practical issues and plans concerning intervention implementation, evaluation, analysing and interpreting the data, and possible policy implications arising from the trial are discussed.
  
  
  BACKGROUND
  clinicaltrial.gov.
  
  
  BACKGROUND
  NCT01563640.
authors.affiliation: Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
authors.forename: Annelies
authors.initials: A
authors.lastname: Wilder-Smith
authors.forename: Peter
authors.initials: P
authors.lastname: Byass
authors.forename: Phanthip
authors.initials: P
authors.lastname: Olanratmanee
authors.forename: Pongsri
authors.initials: P
authors.lastname: Maskhao
authors.forename: Luechai
authors.initials: L
authors.lastname: Sringernyuang
authors.forename: James G
authors.initials: JG
authors.lastname: Logan
authors.forename: Steve W
authors.initials: SW
authors.lastname: Lindsay
authors.forename: Sarah
authors.initials: S
authors.lastname: Banks
authors.forename: Duane
authors.initials: D
authors.lastname: Gubler
authors.forename: Valérie R
authors.initials: VR
authors.lastname: Louis
authors.forename: Yesim
authors.initials: Y
authors.lastname: Tozan
authors.forename: Pattamaporn
authors.initials: P
authors.lastname: Kittayapong
mesh_terms: D000293:Adolescent; D000818:Animals; D002648:Child; D003362:Cost-Benefit Analysis; D018592:Cross-Over Studies; D003715:Dengue / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D003906:Developing Countries; D004199:Disease Vectors; D004311:Double-Blind Method; D017048:Health Care Costs; D006801:Humans; D015994:Incidence; D007300:Insect Control / Q000191:economics / Q000379:methods*; D007306:Insecticides / Q000191:economics; D026023:Permethrin / Q000191:economics; D011481:Protective Clothing / Q000191:economics; D012107:Research Design; D012574:Schools; D012621:Seasons; D013785:Thailand / Q000453:epidemiology; D013997:Time Factors; D035862:Vulnerable Populations
chemical_list: D007306:Insecticides; D026023:Permethrin