title: New insights on the role of CD8(+)CD57(+) T-cells in cancer.
abstract: Incomplete differentiation of CD8+ cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment is associated with cancer progression. We describe a new type of tumor-infiltrating CD8+CD57+ T cell in cancer with hybrid phenotypic and functional properties of both an early effector-memory cell and a terminally-differentiated effector cell. These cells behave as incompletely-differentiated CTLs.
authors.affiliation: Department of Melanoma Medical Oncology; University of Texas M.D. Anderson Cancer Center; Houston, TX USA ; University of Texas Graduate School of Biomedical Sciences; Houston, TX USA ; University of Texas Medical School at Houston; Houston, TX USA.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Wu
authors.forename: Patrick
authors.initials: P
authors.lastname: Hwu
authors.forename: Laszlo G
authors.initials: LG
authors.lastname: Radvanyi