title: Immunization of macaques with soluble HIV type 1 and influenza virus envelope glycoproteins results in a similarly rapid contraction of peripheral B-cell responses after boosting.
abstract: The envelope glycoproteins (Env) represent a critical component of a successful antibody-mediated human immunodeficiency virus type 1 (HIV-1) vaccine. However, immunization with soluble Env was reported to induce short-lived antibody responses, suggesting that Env has unusual immunogenic properties. Here, we directly compared the magnitude and durability of B-cell responses induced by HIV-1 Env and an unrelated soluble viral protein, influenza virus hemagglutinin (HA), in simultaneously inoculated macaques. We demonstrate robust peak responses followed by rapid contraction of circulating antibody and memory B cells for both antigens, suggesting that short-lived responses are not unique to HIV-1 Env but may be a common feature of soluble protein vaccines.
authors.affiliation: Department of Microbiology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Christopher
authors.initials: C
authors.lastname: Sundling
authors.forename: Paola
authors.initials: P
authors.lastname: Martinez
authors.forename: Martina
authors.initials: M
authors.lastname: Soldemo
authors.forename: Mats
authors.initials: M
authors.lastname: Spångberg
authors.forename: Karin Lövgren
authors.initials: KL
authors.lastname: Bengtsson
authors.forename: Linda
authors.initials: L
authors.lastname: Stertman
authors.forename: Mattias N E
authors.initials: MN
authors.lastname: Forsell
authors.forename: Gunilla B
authors.initials: GB
authors.lastname: Karlsson Hedestam
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D000918:Antibody Specificity / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D056724:Immunity, Humoral; D007114:Immunization; D007117:Immunization, Secondary; D007252:Influenza Vaccines / Q000276:immunology; D008251:Macaca / Q000276:immunology; D009975:Orthomyxoviridae / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology*
chemical_list: D016915:AIDS Vaccines; D000914:Antibodies, Viral; D015483:HIV Antibodies; D007252:Influenza Vaccines; D011994:Recombinant Proteins; D014759:Viral Envelope Proteins