title: A window into the invisible wound of war: functional neuroimaging of REM sleep in returning combat veterans with PTSD.
abstract: Relative regional cerebral metabolic rate of glucose in rapid eye movement (REM) sleep and wakefulness was explored in combat veterans with and without posttraumatic stress disorder PTSD, using positron emission tomography. Hypermetabolism in brain regions involved in arousal regulation, fear responses, and reward processing persist during REM sleep in combat veterans with PTSD.
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. germax@upmc.edu
authors.forename: Anne
authors.initials: A
authors.lastname: Germain
authors.forename: Jeffrey
authors.initials: J
authors.lastname: James
authors.forename: Salvatore
authors.initials: S
authors.lastname: Insana
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Herringa
authors.forename: Oommen
authors.initials: O
authors.lastname: Mammen
authors.forename: Julie
authors.initials: J
authors.lastname: Price
authors.forename: Eric
authors.initials: E
authors.lastname: Nofzinger
mesh_terms: D000328:Adult; D055826:Afghan Campaign 2001-; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism; D059907:Functional Neuroimaging; D006801:Humans; D054542:Iraq War, 2003-2011; D011877:Radionuclide Imaging; D012895:Sleep, REM / Q000502:physiology*; D013313:Stress Disorders, Post-Traumatic / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D014728:Veterans / Q000523:psychology*; D014851:Wakefulness / Q000502:physiology