title: Exogenous endothelial cells as accelerators of hematopoietic reconstitution.
abstract: Despite the successes of recombinant hematopoietic-stimulatory factors at accelerating bone marrow reconstitution and shortening the neutropenic period post-transplantation, significant challenges remain such as cost, inability to reconstitute thrombocytic lineages, and lack of efficacy in conditions such as aplastic anemia. A possible means of accelerating hematopoietic reconstitution would be administration of cells capable of secreting hematopoietic growth factors. Advantages of this approach would include: a) ability to regulate secretion of cytokines based on biological need; b) long term, localized production of growth factors, alleviating need for systemic administration of factors that possess unintended adverse effects; and c) potential to actively repair the hematopoietic stem cell niche. Here we overview the field of hematopoietic growth factors, discuss previous experiences with mesenchymal stem cells (MSC) in accelerating hematopoiesis, and conclude by putting forth the rationale of utilizing exogenous endothelial cells as a novel cellular therapy for acceleration of hematopoietic recovery.
authors.affiliation: Regen BioPharma Inc, San Diego, CA, USA.
authors.forename: J Christopher
authors.initials: JC
authors.lastname: Mizer
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Ichim
authors.forename: Doru T
authors.initials: DT
authors.lastname: Alexandrescu
authors.forename: Constantin A
authors.initials: CA
authors.lastname: Dasanu
authors.forename: Famela
authors.initials: F
authors.lastname: Ramos
authors.forename: Andrew
authors.initials: A
authors.lastname: Turner
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Woods
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bogin
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murphy
authors.forename: David
authors.initials: D
authors.lastname: Koos
authors.forename: Amit N
authors.initials: AN
authors.lastname: Patel
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000166:cytology* / Q000378:metabolism; D006410:Hematopoiesis; D016298:Hematopoietic Cell Growth Factors / Q000378:metabolism; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D055153:Stem Cell Niche
chemical_list: D016298:Hematopoietic Cell Growth Factors