title: Evaluation of nitric oxide metabolites in a group of subjects with metabolic syndrome.
abstract: OBJECTIVE
  To evaluate the concentration of metabolites (NO(2)(-), NO(3)(-)) of nitric oxide (NO) in metabolic syndrome (MS).
  
  
  METHODS
  We enrolled 106 subjects (45 women and 61 men) with MS of which 43 (14 women and 27 men) with diabetes mellitus and 63 (31 women and 32 men) without diabetes mellitus, and 54 subjects (19 women and 35 men) as control group. The nitric oxide metabolites (nitrite+nitrate=NOx) were evaluated employing the Griess reagent.
  
  
  RESULTS
  In the whole group of MS subjects was evident, in comparison with control group, a significant increase in NOx. The same finding was also present between control group and diabetic subjects with MS and between control group and nondiabetic subjects with MS. No difference was observed between the two subgroups (diabetic and nondiabetic subjects with MS) about NOx. Contrasting information were obtained examining the linear regression among NOx, age, anthropometric profile, blood pressure values and glycometabolic pattern of subjects with MS.
  
  
  CONCLUSIONS
  In MS subjects we found a significant increase in NOx not influenced by diabetes mellitus. The NOx is a parameter that must be considered in MS keeping in mind that its behavior is related to chronic inflammation that accompanies this clinical condition.
authors.affiliation: Dipartimento di Medicina Interna e Specialistica, Università di Palermo, Italy.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Caimi
authors.forename: Eugenia
authors.initials: E
authors.lastname: Hopps
authors.forename: Maria
authors.initials: M
authors.lastname: Montana
authors.forename: Davide
authors.initials: D
authors.lastname: Noto
authors.forename: Baldassare
authors.initials: B
authors.lastname: Canino
authors.forename: Rosalia
authors.initials: R
authors.lastname: Lo Presti
authors.forename: Maurizio R
authors.initials: MR
authors.lastname: Averna
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism* / Q000503:physiopathology; D008875:Middle Aged; D009566:Nitrates / Q000097:blood*; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000097:blood*; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide