title: Evaluation of cell function upon nanovector internalization.
abstract: In vitro toxicity assays based on the evaluation and retention of advanced and specific cellular functions are proposed to investigate mesoporous silicon nanovectors. This approach provides greater insight compared to simple cellular viability and toxicity assays. Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function.
authors.affiliation: Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA.
authors.forename: Jonathan O
authors.initials: JO
authors.lastname: Martinez
authors.forename: Alessandro
authors.initials: A
authors.lastname: Parodi
authors.forename: Xuewu
authors.initials: X
authors.lastname: Liu
authors.forename: Mikhail G
authors.initials: MG
authors.lastname: Kolonin
authors.forename: Mauro
authors.initials: M
authors.lastname: Ferrari
authors.forename: Ennio
authors.initials: E
authors.lastname: Tasciotti
mesh_terms: D002470:Cell Survival; D002478:Cells, Cultured; D004705:Endocytosis; D006801:Humans; D053758:Nanoparticles