title: Comparison of survival and prognostic factors in patients with gastric adenocarcinoma in T2 and T3.
abstract: OBJECTIVE
  To compare the survival and prognosis after surgical treatment of patients with gastric adenocarcinoma which extends to the muscular layer (T2), and patients whose tumor invades the subserosa (T3).
  
  
  METHODS
  This was a retrospective study of 122 patients with gastric cancer invading the muscularis propria and subserosa, undergoing surgical treatment from January 1997 to December 2008 and followed-up until December 2010. We analyzed demographic, surgical and pathological variables.
  
  
  RESULTS
  Of the 122 patients, 22 (18%) were excluded from the final analysis because they showed: positive margin or less than 15 lymph nodes in the surgical specimen, early postoperative mortality and second primary tumors. Among the 100 patients included, 75 had tumors inveding the muscularis propria (T2) and 25 with extension to the subserosa (T3). Overall survival was 83.8%, and 90.6% for T2 and 52.1% or T3. Univariate analysis showed statistical significance in: lymph node metastasis (p = 0.02), tumor size (p = 0.000), tumor pathological stage (p = 0.000), lymph node pathologic stage (p = 0.000) and staging by classification of groups TNM-UICC/AJCC, 2010 (p = 0.000). In multivariate analysis, independent prognostic factors were tumor size and lymph node pathological staging (pN).
  
  
  CONCLUSIONS
  The lymph node status and tumor size are independent prognostic factors in tumors with invasion of the muscularis propria and in tumors with invasion of subserosa. T2 lesions have smaller size, lower rate of lymph node metastasis and therefore better prognosis than T3.
authors.affiliation: National Cancer Institute, INCA, Rio de Janeiro, Brazil. patriciajuca@ig.com.br
authors.forename: Patrícia Campos
authors.initials: PC
authors.lastname: Jucá
authors.forename: Laercio
authors.initials: L
authors.lastname: Lourenço
authors.forename: Rubens
authors.initials: R
authors.lastname: Kesley
authors.forename: Eduardo Linhares Riello de
authors.initials: EL
authors.lastname: Mello
authors.forename: Ivanir Martins de
authors.initials: IM
authors.lastname: Oliveira
authors.forename: José Humberto Simões
authors.initials: JH
authors.lastname: Correa
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate