title: Branched chain amino acid profile in early chronic kidney disease.
abstract: The nutritional status in chronic kidney disease (CKD) patients is a predictor of prognosis during the first period of dialysis. Serum albumin is the most commonly used nutritional marker. Another index is plasma amino acid profile. Of these, the plasma levels of branched chain amino acids (BCAA), especially valine and leucine, correlate well with nutritional status. Plasma BCAAs were evaluated along with albumin and C-reactive protein in 15 patients of early stages of CKD and 15 age- and sex-matched healthy controls. A significant decrease in plasma valine, leucine and albumin levels was observed in CKD patients when compared with the controls (P <0.05). No significant difference in C-reactive protein (CRP) levels was observed between the two groups. Malnutrition seen in our CKD patients in the form of hypoalbuminemia and decreased concentrations of BCAA points to the need to evaluate the nutritional status in the early stages itself. Simple measures in the form of amino acid supplementation should be instituted early to decrease the morbidity and mortality before start of dialysis in these patients.
authors.affiliation: Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, A.P., India.
authors.forename: M Anil
authors.initials: MA
authors.lastname: Kumar
authors.forename: Aparna Rajeshwar Rao
authors.initials: AR
authors.lastname: Bitla
authors.forename: K V N
authors.initials: KV
authors.lastname: Raju
authors.forename: Suchitra Musturu
authors.initials: SM
authors.lastname: Manohar
authors.forename: V Siva
authors.initials: VS
authors.lastname: Kumar
authors.forename: Srinivasa Rao Pemmaraju Venkata Lakshmi
authors.initials: SR
authors.lastname: Narasimha
mesh_terms: D000328:Adult; D000597:Amino Acids, Branched-Chain / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D018450:Disease Progression; D006801:Humans; D034141:Hypoalbuminemia / Q000097:blood / Q000209:etiology; D007194:India; D018836:Inflammation Mediators / Q000097:blood; D007930:Leucine / Q000097:blood; D044342:Malnutrition / Q000097:blood / Q000209:etiology; D008875:Middle Aged; D009752:Nutritional Status; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications; D012709:Serum Albumin / Q000032:analysis; D014633:Valine / Q000097:blood
chemical_list: D000597:Amino Acids, Branched-Chain; D015415:Biomarkers; D018836:Inflammation Mediators; D012709:Serum Albumin; D002097:C-Reactive Protein; D007930:Leucine; D014633:Valine