title: Association between low renal function and tooth loss over 5 years.
abstract: OBJECTIVE
  This longitudinal study evaluated the relationship between low renal function and tooth loss in elderly subjects.
  
  
  METHODS
  Subjects comprised 406 female subjects (55-74 years old) who agreed to participate in a baseline examination and a follow-up examination after 5 years. Serum cystatin C levels were used to assess renal function. Multiple logistic regression analysis was used to evaluate the relationship between tooth loss and change in serum cystatin C levels over 5 years. Tooth loss over 5 years (0: no, 1: yes) was used as the dependent variable. Seven variables were used as independent variables, including change in serum cystatin C levels over 5 years.
  
  
  RESULTS
  Results of multiple logistic regression analysis showed that cystatin C change over 5 years, age, number of remaining teeth at baseline, number of sites with ≥4 mm clinical attachment level at baseline and serum 25-hydroxyvitamin D levels at baseline were significantly associated with tooth loss. The odds ratio for tooth loss with cystatin C change over 5 years was 7.70 (p=0.029).
  
  
  CONCLUSIONS
  This study indicates a relationship between serum cystatin C levels and number of missing teeth, and thus suggests that low renal function is associated with tooth loss.
authors.affiliation: Department of Oral Health and Welfare, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yoshihara
authors.forename: Masanori
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Hideo
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D055316:Cystatin C / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D057187:Independent Living / Q000706:statistics & numerical data; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000453:epidemiology; D017622:Periodontal Attachment Loss / Q000453:epidemiology; D051437:Renal Insufficiency / Q000097:blood / Q000453:epidemiology*; D016388:Tooth Loss / Q000453:epidemiology*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
chemical_list: C525030:CST3 protein, human; D055316:Cystatin C; D014807:Vitamin D; C104450:25-hydroxyvitamin D