title: A general method for the enantioselective synthesis of α-chiral heterocycles.
abstract: The enantioselective formation of stereocenters proximal to unprotected heterocycles has been accomplished. Thus, vinyl boronic acids are added to heterocycle-appended enones via a modified-BINOL catalyst. Catalyst design was key to enable a general reaction. High yields and useful er's are observed for a host of common heteroaryls.
authors.affiliation: Department of Chemistry, University of Houston, 136 Fleming Building, Houston, Texas 77204-5003, USA.
authors.forename: Phong Q
authors.initials: PQ
authors.lastname: Le
authors.forename: Thien S
authors.initials: TS
authors.lastname: Nguyen
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: May
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds