title: [Regulation of intercellular adhesion during epithelial             morphogenesis].
abstract: The epithelium is one of the most abundant tissues in metazoans. It is required to           generate stable chemical and mechanical barriers between physiological compartments (fluid           matrix/external environment). This function is based on multiple intercellular junctions,           which insulate and stabilize cell-cell contacts in the tissue. Despite this apparent           robustness, epithelia can be extensively remodeled during wound healing, embryogenesis and           tumor progression. The capacity to be remodeled while keeping tissue cohesion requires a           perfect balance between stability and plasticity of intercellular junctions. The balance           is partially regulated by intercellular adhesion, which is mostly based on adherens           junctions and the transmembrane protein E-cadherin. The aim of this review is to report           the molecular basis of the balance between plasticity and robustness in the epithelium. We           will first present the minimal physical framework used to describe epithelial cell shape.           We will then describe the main processes involved in intercellular adhesion regulation and           their functions during epithelial morphogenesis. Eventually, we will analyze the           relationship and the coupling between adhesive forces and cortical tension.
authors.affiliation: Institut de Biologie du Developpement de Marseille Luminy, Marseille, France. romain.levayer@ibdml.univmed.fr
authors.forename: Romain
authors.initials: R
authors.lastname: Levayer
mesh_terms: D022005:Adherens Junctions / Q000502:physiology; D000818:Animals; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D004705:Endocytosis; D004847:Epithelial Cells / Q000502:physiology* / Q000648:ultrastructure; D004848:Epithelium / Q000254:growth & development* / Q000648:ultrastructure; D007365:Intercellular Junctions / Q000502:physiology; D009024:Morphogenesis / Q000502:physiology*
chemical_list: D015820:Cadherins