title: Cell biology of infection by Legionella pneumophila.
abstract: Professional phagocytes digest internalized microorganisms by actively delivering them into the phagolysosomal compartment. Intravacuolar bacterial pathogens have evolved a variety of effective strategies to bypass the default pathway of phagosomal maturation to create a niche permissive for their survival and propagation. Here we discuss recent progress in our understanding of the sophisticated mechanisms used by Legionella pneumophila to survive in phagocytes.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Zhao-Qing
authors.initials: ZQ
authors.lastname: Luo
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D058947:Bacterial Secretion Systems; D016923:Cell Death; D004705:Endocytosis; D006801:Humans; D016952:Legionella pneumophila / Q000502:physiology*; D007877:Legionnaires' Disease / Q000382:microbiology*; D050356:Lipid Metabolism; D008264:Macrophages / Q000382:microbiology; D010586:Phagocytes / Q000382:microbiology; D010587:Phagocytosis; D010588:Phagosomes / Q000382:microbiology; D015398:Signal Transduction; D054875:Ubiquitination
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems