title: [Immunocorrection of apoptogenic effect of pertussis preparations with neutrophilokines].
abstract: OBJECTIVE
  Study the possibility of resistance increase of macrophages of experimental animals to apoptogenic effect of pertussis preparations with neutrophilokines.
  
  
  METHODS
  Apoptosis was evaluated in Coulter flow cytofluorimeter after staining with propidium iodide, as well as by characteristic morphologic changes in cells stained by histological preparations and by DNA fragmentation.
  
  
  RESULTS
  The studies performed showed that pertussis preparations cause apoptosis of peritoneal macrophages leading to their alteration. Neutrophilokines induced by pertussis preparations were also established to suppress macrophage apoptosis.
  
  
  CONCLUSIONS
  The results of our studies indicate the possibility to use neutrophilokines for immunocorrection of macrophage apoptosis induced by pertussis preparations.
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Tiukavkina
authors.forename: A A
authors.initials: AA
authors.lastname: Savis'ko
authors.forename: G G
authors.initials: GG
authors.lastname: Kharseeva
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001886:Bordetella pertussis / Q000737:chemistry* / Q000472:pathogenicity; D002478:Cells, Cultured; D016207:Cytokines / Q000276:immunology / Q000494:pharmacology*; D053938:DNA Fragmentation / Q000187:drug effects; D005434:Flow Cytometry; D006168:Guinea Pigs; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism*; D037342:Pertussis Toxin / Q000494:pharmacology*; D011419:Propidium
chemical_list: D016207:Cytokines; D011419:Propidium; D037342:Pertussis Toxin