title: Face selective reduction of the exocyclic double bond in isatin derived spirocyclic lactones.
abstract: We report an unusual face selective reduction of the exocyclic double bond in the α-methylene-γ-butyrolactone motif of spiro-oxindole systems. The spiro-oxindoles were assembled by an indium metal mediated Barbier-type reaction followed by an acid catalyzed lactonization.
authors.affiliation: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Rana
authors.forename: Amarnath
authors.initials: A
authors.lastname: Natarajan
mesh_terms: D007204:Indium / Q000737:chemistry; D007510:Isatin / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D007783:Lactones; D013141:Spiro Compounds; D007204:Indium; D007510:Isatin