title: Immunosuppressive and biologic therapy for ulcerative colitis.
abstract: BACKGROUND
  Recent insight into the pathogenesis of ulcerative colitis have led to the development of new treatment options. A better understanding of IBD pathophysiology has progressively led to a more frequent use of immunosuppressants and biologics.
  
  
  METHODS
  The use of the conventional immunomodulators, such as azathioprine, 6-mercaptopurine, methotrexate, cyclosporine and tacrolimus, and anti-TNF-α agents, such as infliximab and adalimumab, in the treatment of ulcerative colitis are reviewed. Moreover, the ongoing studies evaluating the efficacy of emerging immunosuppressants in treating patients with ulcerative colitis are discussed. An effort is made to explore some critical areas in which early and more diffuse use of these agents may be advocated.
  
  
  CONCLUSIONS
  Ulcerative colitis is a chronic condition mainly affecting young people in their more productive age, and determining high indirect costs to the patient and to society. Thus, there is a need for optimizing and renewing our traditional therapeutic approach to UC, and new therapies beyond conventional treatment options possibly aiming to change the poor clinical course of many patients with ulcerative colitis. Keeping in mind this potentially new therapeutic scenario, there are some critical areas in which early and more diffuse use of conventional and emerging new immunomodulators is advocated.
authors.affiliation: Cattedra e Divisione di Gatroenterologia, ed Endoscopia Digestiva, Azienda, Ospedaliera L. Sacco, Polo Universitario, Italy. samari1@tin.it
authors.forename: Sandro
authors.initials: S
authors.lastname: Ardizzone
authors.forename: Andrea
authors.initials: A
authors.lastname: Cassinotti
authors.forename: Roberto
authors.initials: R
authors.lastname: de Franchis
mesh_terms: D000367:Age Factors; D000818:Animals; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000503:physiopathology; D015195:Drug Design; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D007155:Immunologic Factors; D007166:Immunosuppressive Agents