title: Cyclosporine rescue therapy in autoimmune liver cirrhosis: a case report.
abstract: Autoimmune hepatitis is an inflammatory condition of the liver that can lead to significant morbidity and mortality. Corticosteroids with or without azathioprine have been shown to improve outcome and are the current standard of care in autoimmune hepatitis patients. However, long-term use of corticosteroids and use of azathioprine could be associated with significant adverse effects that prevent their continued use at optimal dosages or may even require complete cessation. We present a patient with autoimmune liver cirrhosis who was intolerant of corticosteroid and azathioprine, who was successfully treated with cyclosporine. To our knowledge, cyclosporine use has not been reported previously in autoimmune cirrhosis, although it has been used in autoimmune hepatitis patients with reported success and good tolerability. We conclude that cyclosporine seems to be an effective alternative to azathioprine as a steroid-sparing agent in both non-cirrhotic and cirrhotic autoimmune hepatitis.
authors.affiliation: University of Malaya, Department of Medicine, Kuala Lumpur, Malaysia. wahkheong2003@hotmail.com
authors.forename: Chan
authors.initials: C
authors.lastname: Wah-Kheong
authors.forename: Vijayasangkar
authors.initials: V
authors.lastname: Jaganathan
authors.forename: Mahadeva
authors.initials: M
authors.lastname: Sanjiv
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D016572:Cyclosporine / Q000008:administration & dosage*; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000276:immunology; D008875:Middle Aged
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine