title: [Epidemiology of Escherichia coli neonatal meningitis].
abstract: BACKGROUND
  Neonatal bacterial meningitis has a mortality rate over 10 % and induces neurological sequellae in 20 to 50 % of cases. Escherichia coli (E. coli) is the second cause behind Group B streptococcus (GBS). The clinical and epidemiological features of neonatal meningitis due to E. coli between 2001 and 2010 with the data from the National Observatory are presented here.
  
  
  METHODS
  Cases of child meningitis were prospectively collected since 2001 by a network of 252 pediatric wards associated with 166 microbiology laboratories. Risk factors, clinical signs, cerebrospinal fluid analysis, treatment and mortality were collected.
  
  
  RESULTS
  638 cases of neonatal bacterial meningitis were reported by 114 pediatric wards, among which 28 % (n=180) due to E. coli. If GBS prevailed in early and late-onset forms in term infants (84 % and 57 % for GBS vs 13 % and 28 % for E. coli), E. coli prevailed in preterm infants (42 % vs 37 % for GBS), and this trend increased in very preterm (GA < 33) (53 % vs 18 %). Number of E. coli early and late-onset meningitis didn't significantly vary over time. Antibiotherapy most often associated a 3(rd) generation cephalosporin, an aminosid and ciprofloxacin; sterilisation of the cerebrospinal fluid was achieved within day 2 to day 4 in 84 % of newborns. Only 3 strains were ESBL. Mortality was 11 % with E. coli, comparable to GBS (12 %) but reached 15 % in preterm infants.
  
  
  CONCLUSIONS
  E. coli was the prevailing cause of early and late onset bacterial meningitis in premature infants, associated with a higher mortality than in term infants.
authors.affiliation: Service de Pédiatrie générale, Université Paris Didérot, hôpital Robert Debré, 48, boulevard Serrurier, 75019 Paris, France. jean.gaschignard@inserm.fr
authors.forename: J
authors.initials: J
authors.lastname: Gaschignard
authors.forename: C
authors.initials: C
authors.lastname: Levy
authors.forename: E
authors.initials: E
authors.lastname: Bingen
authors.forename: R
authors.initials: R
authors.lastname: Cohen
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D020814:Meningitis, Escherichia coli / Q000453:epidemiology*; D011446:Prospective Studies