title: Structural vaccinology starts to deliver.
abstract: Following the impact of the genomics revolution on vaccine research and the development of reverse vaccinology, it was predicted that another new approach, structure-based antigen design, would become a driving force for vaccine innovation. Now, 5 years on, there are several examples of how structure-based design, or structural vaccinology, can deliver new vaccine antigens that were not possible before. Here, we discuss some of these examples and the contribution of structural vaccinology to our understanding of the protective epitopes of important bacterial and viral pathogens.
authors.affiliation: Novartis Vaccines and Diagnostics Inc., 350 Massachusetts Avenue, Cambridge, Massachusetts                 02139, USA.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Dormitzer
authors.forename: Guido
authors.initials: G
authors.lastname: Grandi
authors.forename: Rino
authors.initials: R
authors.lastname: Rappuoli
mesh_terms: D000818:Animals; D000941:Antigens / Q000235:genetics* / Q000276:immunology*; D015195:Drug Design; D000939:Epitopes / Q000235:genetics* / Q000276:immunology*; D023281:Genomics / Q000379:methods; D006801:Humans; D014612:Vaccines / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*
chemical_list: D000941:Antigens; D000939:Epitopes; D014612:Vaccines