title: Pd-catalyzed C-H oxygenation with TFA/TFAA: expedient access to oxygen-containing heterocycles and late-stage drug modification.
abstract: Acid brings the oxygen: a general method for palladium-catalyzed C-H oxygenation has been developed for the facile synthesis of a wide range of functionalized phenols with readily available aryl ketones, benzoates, benzamides, acetanilides, and sulfonamides. A trifluoroacetic acid/trifluoroacetic acid anhydride solvent system serves as the oxygen source and is the critical factor for C-H activation.
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Shan
authors.forename: Xinglin
authors.initials: X
authors.lastname: Yang
authors.forename: Linlin
authors.initials: L
authors.lastname: Ma
authors.forename: Yu
authors.initials: Y
authors.lastname: Rao
mesh_terms: D000089:Acetic Anhydrides / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D005463:Fluoroacetates / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D008968:Molecular Conformation; D010100:Oxygen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D014269:Trifluoroacetic Acid / Q000737:chemistry*
chemical_list: D000089:Acetic Anhydrides; D005463:Fluoroacetates; D006571:Heterocyclic Compounds; C017958:trifluoroacetic anhydride; D010165:Palladium; D002244:Carbon; D006859:Hydrogen; D014269:Trifluoroacetic Acid; D010100:Oxygen