title: Separation and study of the range of plasminogen isoforms in patients with prostate cancer.
abstract: Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and higher pI values compared to isoforms found in the control group.
authors.affiliation: Institute of Arid Zones, Southern Scientific Center of the Russian Academy of Sciences, 344006 Rostov-on-Don, Russia. johnnyeugenie@gmail.com
authors.forename: E F
authors.initials: EF
authors.lastname: Shin
authors.forename: D I
authors.initials: DI
authors.lastname: Vodolazhsky
authors.forename: A Yu
authors.initials: AY
authors.lastname: Golikov
authors.forename: T N
authors.initials: TN
authors.lastname: Belova
authors.forename: N V
authors.initials: NV
authors.lastname: Boyko
authors.forename: D V
authors.initials: DV
authors.lastname: Zimakov
authors.forename: E N
authors.initials: EN
authors.lastname: Cherkasova
authors.forename: M I
authors.initials: MI
authors.lastname: Kogan
authors.forename: M B
authors.initials: MB
authors.lastname: Chibichian
authors.forename: S A
authors.initials: SA
authors.lastname: Moshkovskii
authors.forename: V A
authors.initials: VA
authors.lastname: Tarasov
authors.forename: D G
authors.initials: DG
authors.lastname: Matishov
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis / Q000302:isolation & purification*; D011471:Prostatic Neoplasms / Q000097:blood*; D020033:Protein Isoforms / Q000097:blood
chemical_list: D020033:Protein Isoforms; D010958:Plasminogen