title: Carbamate protection of AChE against inhibition by agricultural chemicals.
abstract: The carbamate pyridostigmine bromide has been used as a pretreatment to protect individuals from the nerve agent soman. Previous research showed that pyridostigmine significantly protected human muscle acetylcholinesterase in vitro from soman and bovine red blood cell acetylcholinesterase from some organophosphorous pesticides. Research presented here demonstrates that pretreatment with other carbamates also protects acetylcholinesterase from inhibition by the pesticides chlorpyrifos-oxon and diazinon-oxon, but not from malaoxon.
authors.affiliation: Animal Science Department, University of California-Davis, Davis, CA 95616, USA. bwwilson@ucdavis.edu
authors.forename: Barry W
authors.initials: BW
authors.lastname: Wilson
authors.forename: Francisca J
authors.initials: FJ
authors.lastname: Rusli
authors.forename: Michelle Ka
authors.initials: MK
authors.lastname: Yan Tam
authors.forename: Ed
authors.initials: E
authors.lastname: DePeters
authors.forename: John D
authors.initials: JD
authors.lastname: Henderson
mesh_terms: D000818:Animals; D002219:Carbamates / Q000494:pharmacology*; D002417:Cattle; D004390:Chlorpyrifos / Q000031:analogs & derivatives / Q000633:toxicity; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D010755:Organophosphates / Q000633:toxicity*; D009943:Organophosphorus Compounds / Q000633:toxicity; D010575:Pesticides / Q000633:toxicity*
chemical_list: D002219:Carbamates; D002800:Cholinesterase Inhibitors; D010755:Organophosphates; D009943:Organophosphorus Compounds; D010575:Pesticides; C009618:O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate; C000912:diazoxon; D004390:Chlorpyrifos