title: Along the pituitary-testis-prostate axis, serum total testosterone is a significant preoperative variable independently contributing to separating the prostate cancer population into prostatectomy Gleason score groups.
abstract: OBJECTIVE
  To investigate, along the pituitary- testis- prostate axis, the potential of preoperative serum TT in contributing to defining separate prostatectomy Gleason score (pGS) groups of the prostate cancer (PC) population.
  
  
  METHODS
  The data of 126 patients operated on for PC were retrospectively reviewed. No patient had previously received 5α-reductase inhibitor, luteinizing hormone (LH)-releasing hormone analogs or testosterone replacement treatment. The patient population was grouped according to the prostatectomy Gleason score (pGS) as 6=3+3, 7=3+4, 7=4+3 and 8-10. Twelve variables were simultaneously investigated in each group: age, prolactin (PRL), follicle stimulating hormone (FSH), LH, total testosterone (TT), free testosterone (FT), estradiol (Er), prostate specific antigen (PSA), percentage of prostate biopsy positive cores (P+), biopsy Gleason score (bGS), overall cancer volume estimated as percentage of prostate volume (V+) and prostate weight (Wi). Univariate analysis of variance (ANOVA), multivariate analysis of variance (MANOVA) and multivariate discriminant analysis were the statistical methods used for evaluating the data.
  
  
  RESULTS
  There were 38 patients in pGS 6=3+3, 57 in pGS 7=3+4, 15 in pGS 7=4+3 and 16 in pGS 8-10. ANOVA showed that bGS (p<0.0001), P+ (p<0.0001), V+ (p<0.0001), PSA (p=0.02), Wi (p=0.001) and TT (p=0.04) were significantly different in the four pGS groups. MANOVA tests showed that only bGS (p<0.0001) and TT (p=0.005) were the significant variables that individually and independently contributed a significant amount to separation of the four pGS groups of the PC population. Multivariate discriminant analysis confirmed that TT (p=0.005) and bGS (p<0.0001) were the only variables that independently and significantly contributed to separating the pGS groups.
  
  
  CONCLUSIONS
  along the pituitary- testis- prostate axis, serum TT is a significant preoperative variable that independently contributes to separating the prostate cancer population into pGS score groups. Pretreatment baseline serum TT levels should be measured for their inclusion in nomograms and future neural networks to be considered in the patient population diagnosed with PC.
authors.affiliation: Urologic Clinic, Verona, Italy. drporcaro@yahoo.com
authors.forename: Antonio B
authors.initials: AB
authors.lastname: Porcaro
authors.forename: Aldo
authors.initials: A
authors.lastname: Petrozziello
authors.forename: Claudio
authors.initials: C
authors.lastname: Ghimenton
authors.forename: Filippo
authors.initials: F
authors.lastname: Migliorini
authors.forename: Teodoro
authors.initials: T
authors.lastname: Sava
authors.forename: Beatrice
authors.initials: B
authors.lastname: Caruso
authors.forename: Claudio
authors.initials: C
authors.lastname: Cocco
authors.forename: Mario
authors.initials: M
authors.lastname: Romano
authors.forename: Walter
authors.initials: W
authors.lastname: Artibani
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D008297:Male; D060787:Neoplasm Grading / Q000379:methods; D010902:Pituitary Gland / Q000502:physiology; D011467:Prostate / Q000502:physiology; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000145:classification* / Q000473:pathology*; D012189:Retrospective Studies; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D013739:Testosterone