title: The role of oxidative stress in postprandial endothelial dysfunction.
abstract: Endothelial dysfunction is a turning point in the initiation and development of atherosclerosis and its complications and is predictive of future cardiovascular events. Ingestion of high-carbohydrate or high-fat meals often results in postprandial hyperglycaemia and/or hypertriacylglycerolaemia that may lead to a transient impairment in endothelial function. The present review will discuss human studies evaluating the impact of high-carbohydrate and high-fat challenges on postprandial endothelial function as well as the potential role of oxidative stress in such postprandial metabolic alterations. Moreover, the present review will differentiate the postprandial endothelial and oxidative impact of meals rich in varying fatty acid types.
authors.affiliation: Montreal Heart Institute, Montreal, QC, Canada.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lacroix
authors.forename: Christine Des
authors.initials: CD
authors.lastname: Rosiers
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Tardif
authors.forename: Anil
authors.initials: A
authors.lastname: Nigam
mesh_terms: D050197:Atherosclerosis; D059305:Diet, High-Fat / Q000009:adverse effects; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000009:adverse effects; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005227:Fatty Acids / Q000008:administration & dosage; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000503:physiopathology*; D015228:Hypertriglyceridemia / Q000209:etiology / Q000503:physiopathology*; D015227:Lipid Peroxidation; D018384:Oxidative Stress / Q000502:physiology*; D044242:Trans Fatty Acids / Q000008:administration & dosage
chemical_list: D004040:Dietary Carbohydrates; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D044242:Trans Fatty Acids