title: Role of oleic acid in immune system; mechanism of action; a review.
abstract: BACKGROUND
  Although n-3 polyunsaturated fatty acids have been widely described as anti-inflammatory fats, little is known about the role of oleic acid in immune system.
  
  
  OBJECTIVE
  The aim of the present review is to join all the reports available in order to analyze where exactly the knowledge concerning this topic is and what the causes of the controversial data could be.
  
  
  METHODS
  We searched electronic databases and bibliographies of selected articles were inspected for further reference.
  
  
  RESULTS
  Diets rich in oleic acid have beneficial effects in inflammatory-related diseases. In addition, a wide range of studies evaluate the effect of oleic acid in different cellular functions thus reporting a potential mechanism for the biological effect of such a fat. However, some controversial data can be found in literature, maybe related to the kind of study or even the dose of the reagent added.
  
  
  CONCLUSIONS
  In conclusion, oleic acid could be reported as an anti-inflammatory fatty acid playing a role in the activation of different pathways of immune competent cells.
authors.affiliation: Área de Nutrición y Bromatología, Facultad de Ciencias, Universidad de Burgos, Burgos, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Carrillo
authors.forename: M del Ma
authors.initials: Mdel M
authors.lastname: Cavia
authors.forename: S
authors.initials: S
authors.lastname: Alonso-Torre
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D004032:Diet; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007249:Inflammation / Q000517:prevention & control; D019301:Oleic Acid / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D019301:Oleic Acid