title: Comet: an open-source MS/MS sequence database search tool.
abstract: Proteomics research routinely involves identifying peptides and proteins via MS/MS sequence database search. Thus the database search engine is an integral tool in many proteomics research groups. Here, we introduce the Comet search engine to the existing landscape of commercial and open-source database search tools. Comet is open source, freely available, and based on one of the original sequence database search tools that has been widely used for many years.
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA 98195-8050, USA. engj@u.washington.edu
authors.forename: Jimmy K
authors.initials: JK
authors.lastname: Eng
authors.forename: Tahmina A
authors.initials: TA
authors.lastname: Jahan
authors.forename: Michael R
authors.initials: MR
authors.lastname: Hoopmann
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D030562:Databases, Protein; D006801:Humans; D010455:Peptides / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D040901:Proteomics; D057386:Search Engine; D012984:Software; D053719:Tandem Mass Spectrometry
chemical_list: D010455:Peptides; D011506:Proteins