title: Trends in survival after in-hospital cardiac arrest.
abstract: BACKGROUND
  Despite advances in resuscitation care in recent years, it is not clear whether survival and neurologic function after in-hospital cardiac arrest have improved over time.
  
  
  METHODS
  We identified all adults who had an in-hospital cardiac arrest at 374 hospitals in the Get with the Guidelines-Resuscitation registry between 2000 and 2009. Using multivariable regression, we examined temporal trends in risk-adjusted rates of survival to discharge. Additional analyses explored whether trends were due to improved survival during acute resuscitation or postresuscitation care and whether they occurred at the expense of greater neurologic disability in survivors.
  
  
  RESULTS
  Among 84,625 hospitalized patients with cardiac arrest, 79.3% had an initial rhythm of asystole or pulseless electrical activity, and 20.7% had ventricular fibrillation or pulseless ventricular tachycardia. The proportion of cardiac arrests due to asystole or pulseless electrical activity increased over time (P<0.001 for trend). Risk-adjusted rates of survival to discharge increased from 13.7% in 2000 to 22.3% in 2009 (adjusted rate ratio per year, 1.04; 95% confidence interval [CI], 1.03 to 1.06; P<0.001 for trend). Survival improvement was similar in the two rhythm groups and was due to improvement in both acute resuscitation survival and postresuscitation survival. Rates of clinically significant neurologic disability among survivors decreased over time, with a risk-adjusted rate of 32.9% in 2000 and 28.1% in 2009 (adjusted rate ratio per year, 0.98; 95% CI, 0.97 to 1.00; P=0.02 for trend).
  
  
  CONCLUSIONS
  Both survival and neurologic outcomes after in-hospital cardiac arrest have improved during the past decade at hospitals participating in a large national quality-improvement registry. (Funded by the American Heart Association.).
authors.affiliation: University of Iowa Hospitals and Clinics, Department of Internal Medicine, Division of Cardiovascular Diseases, 200 Hawkins Dr., Suite 4430 RCP, Iowa City, IA 52242, USA. saket-girotra@uiowa.edu
authors.forename: Saket
authors.initials: S
authors.lastname: Girotra
authors.forename: Brahmajee K
authors.initials: BK
authors.lastname: Nallamothu
authors.forename: John A
authors.initials: JA
authors.lastname: Spertus
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Harlan M
authors.initials: HM
authors.lastname: Krumholz
authors.forename: Paul S
authors.initials: PS
authors.lastname: Chan
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006323:Heart Arrest / Q000401:mortality* / Q000628:therapy; D017052:Hospital Mortality / Q000639:trends*; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000453:epidemiology; D010351:Patient Discharge; D058996:Quality Improvement; D012042:Registries; D020379:Risk Adjustment; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology