title: Epithelioid angiosarcoma metastases to the bone marrow manifesting as erythroblastic anemia and leukocytosis: a case report and review of the literature.
abstract: Bone marrow is an exceptionally uncommon site of metastatic dissemination in angiosarcoma (AS) as only single case reports have been published so far. We report a case of a 72-year-old male with epithelioid angiosarcoma of the liver who subsequently developed erythroblastic anemia. The trephine bone marrow biopsy revealed total replacement of the normal hematopoiesis by diffuse infiltrate of AS. This rare complication of the clinical course of this tumor should be taken into account in the pathological diagnosis of patients with AS presenting with hematological abnormalities.
authors.affiliation: Department of Pathology, Medical University of Gdansk, Gdansk, Poland. czapiewskipiotr@gumed.edu.pl
authors.forename: Piotr
authors.initials: P
authors.lastname: Czapiewski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Ważny
authors.forename: Ewa
authors.initials: E
authors.lastname: Lewicka-Nowak
authors.forename: Wojciech
authors.initials: W
authors.lastname: Biernat
mesh_terms: D019046:Bone Marrow Neoplasms / Q000150:complications / Q000556:secondary*; D006394:Hemangiosarcoma / Q000150:complications / Q000556:secondary*; D006801:Humans; D007964:Leukocytosis / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D017086:beta-Thalassemia / Q000209:etiology*