title: Overweight, obesity and weight gain up to three years after liver transplantation.
abstract: BACKGROUND
  Previous studies have shown that weight gain commonly occurs after liver transplantation (LTx). Few risk factors have been studied.
  
  
  OBJECTIVE
  The aim of this study was to assess the weight changes and incidence excessive weight up to 3 years after surgery.
  
  
  METHODS
  Post-LTx patients were assessed for their weight changes and incidence of excessive weight before liver disease; on the first outpatient appointment after LTx; 3 and 6 mo after LTx; 1; 2 and 3y after LTx. Demographic, socioeconomic, lifestyle and clinical variables were collected to assess risk factors for weight gain, overweight and obesity using linear and logistic regression analysis.
  
  
  RESULTS
  Eighty patients undergoing LTx between 1997/2006 were assessed. Patients lost an average of 9.1 kg during liver disease. This weight was recovered within 1 year after surgery; after 3 years, patients had gained an average of 11.6 kg. The incidence of excessive weight increased over the years, and 56.4% of patients were overweight in the 3 years after LTx; most of them were obese (30.0%). Risk factors for weight gain on the third year after LTx were greater BMI before liver disease (p < 0.01); former smoker (p < 0.01); family history of overweight (p = 0.04); being hosewife/unemployed/retired (p = 0.08); alcoholic indication for LTx (p = 0.02). Risk factors for incidence of excessive weight on the third year after LTx were being married (RR: 13.13; CI: 1.33-125.0); being former smoker (RR: 4.68; CI: 1.16-18.85); greater age at LTx (RR: 1.1; CI: 1.02-1.20).
  
  
  CONCLUSIONS
  Post-LTx patients experienced weight gain after surgery, mainly during the 1 year after operation and increased progressive incidence up to 3 years, due to different risk factors, some of them can be prevented.
authors.affiliation: Adult Health Post Graduation Program, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Lucilene.rezende@gmail.com
authors.forename: L
authors.initials: L
authors.lastname: Rezende Anastácio
authors.forename: L
authors.initials: L
authors.lastname: García Ferreira
authors.forename: J
authors.initials: J
authors.lastname: Costa Liboredo
authors.forename: H
authors.initials: H
authors.lastname: de Sena Ribeiro
authors.forename: A
authors.initials: A
authors.lastname: Soares Lima
authors.forename: E
authors.initials: E
authors.lastname: García Vilela
authors.forename: M I T D
authors.initials: MI
authors.lastname: Correia
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D005260:Female; D006801:Humans; D008019:Life Style; D016031:Liver Transplantation / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology* / Q000209:etiology; D050177:Overweight / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D012959:Socioeconomic Factors; D015430:Weight Gain / Q000502:physiology*