title: Synthesis of novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones and evaluation of their biocidal effects.
abstract: Novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones have been synthesized in high yields by treatment of the corresponding oxo analogs with Lawesson's reagent. The structure has been confirmed by X-ray analysis. The compounds were tested for in vitro antifungal activity against Rhizoctonia bataticola, Sclerotium rolfsii, Fusarium oxysporum and Alternaria porii. The compounds exhibited moderate to good activity against all pathogens. Insecticidal activity of these compounds against Spodoptera litura was observed to be comparable to commercial pyrethroid insecticide, cypermethrin. The urease inhibitory activity has also been studied.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110 007, India. jmkhurana1@yahoo.co.in
authors.forename: Jitender M
authors.initials: JM
authors.lastname: Khurana
authors.forename: Devanshi
authors.initials: D
authors.lastname: Magoo
authors.forename: Komal
authors.initials: K
authors.lastname: Aggarwal
authors.forename: Nisha
authors.initials: N
authors.lastname: Aggarwal
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Chitra
authors.initials: C
authors.lastname: Srivastava
mesh_terms: D000528:Alternaria / Q000187:drug effects*; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects*; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D012232:Rhizoctonia / Q000187:drug effects*; D018411:Spodoptera / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship; D014510:Urease / Q000037:antagonists & inhibitors / Q000378:metabolism; D014966:Xanthenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D007306:Insecticides; D014966:Xanthenes; D014510:Urease