title: Hepatitis C viral kinetics: the past, present, and future.
abstract: Mathematical modeling of hepatitis C viral kinetics has been an important tool in understanding hepatitis C virus (HCV) infection dynamics and in estimating crucial in vivo parameters characterizing the effectiveness of HCV therapy. Because of the introduction of direct-acting antiviral agents, there is a need to extend previous models so as to understand, characterize, and compare various new HCV treatment regimens. Here we review recent modeling efforts in this direction.
authors.affiliation: Theoretical Biology and Biophysics, Los Alamos National Laboratory, NM 87545, USA.
authors.forename: Anushree
authors.initials: A
authors.lastname: Chatterjee
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Smith
authors.forename: Alan S
authors.initials: AS
authors.lastname: Perelson
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002219:Carbamates; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D016174:Hepacivirus / Q000187:drug effects / Q000502:physiology*; D006526:Hepatitis C / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use; D008954:Models, Biological; D009842:Oligopeptides / Q000494:pharmacology / Q000627:therapeutic use; D011480:Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011759:Pyrrolidines; D000077385:Silybin; D012838:Silymarin / Q000494:pharmacology / Q000627:therapeutic use; D014633:Valine / Q000031:analogs & derivatives
chemical_list: C552098:2'-fluoro-2'-methyl-3',5'-diisobutyryldeoxycytidine; D000998:Antiviral Agents; D002219:Carbamates; D007093:Imidazoles; D009842:Oligopeptides; D011480:Protease Inhibitors; D011759:Pyrrolidines; D012838:Silymarin; D003841:Deoxycytidine; D000077385:Silybin; C486464:telaprevir; D014633:Valine; C549273:daclatasvir