title: Differentiation of prions from L-type BSE versus sporadic Creutzfeldt-Jakob disease.
abstract: We compared transmission characteristics for prions from L-type bovine spongiform encephalopathy and MM2-cortical sporadic Creutzfeldt-Jakob disease in the Syrian golden hamster and an ovine prion protein-transgenic mouse line and isolated distinct prion strains. Our findings suggest the absence of a causal relationship between these diseases, but further investigation is warranted.
authors.affiliation: Agence Nationale de Sécurité Sanitaire (Anses), Lyon, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Nicot
authors.forename: Anna
authors.initials: A
authors.lastname: Bencsik
authors.forename: Eric
authors.initials: E
authors.lastname: Morignat
authors.forename: Nadine
authors.initials: N
authors.lastname: Mestre-Francés
authors.forename: Armand
authors.initials: A
authors.lastname: Perret-Liaudet
authors.forename: Thierry
authors.initials: T
authors.lastname: Baron
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002417:Cattle; D007562:Creutzfeldt-Jakob Syndrome / Q000401:mortality / Q000473:pathology / Q000635:transmission*; D006224:Cricetinae; D016643:Encephalopathy, Bovine Spongiform / Q000401:mortality / Q000473:pathology / Q000635:transmission*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D011328:Prions / Q000378:metabolism / Q000472:pathogenicity*
chemical_list: D011328:Prions