title: Refractory chronic cough: new perspectives in diagnosis and treatment.
abstract: In patients with chronic cough, nearly 40% of the population does not experience definitive improvement of their cough despite correctly applying the anatomic diagnosis. In many of these patients with refractory cough, laryngeal symptoms are frequent. The region of the larynx/pharynx is configured as a bridge between the esophagus and the upper and lower respiratory tract. The association of reflux in patients with chronic cough and symptoms such as globus pharyngis, itchiness or the need to clear one's throat have recently been given attention due to the possibility of joint therapeutic intervention of the gastroesophageal reflux and larynx, both with new medications as well as with laryngeal rehabilitation therapies, with observed benefits in the disappearance of chronic cough in cases that had been previously labeled as refractory.
authors.affiliation: Unidad de Tos Crónica y Asma de Difícil Control, Servicio de Neumología, Hospital Ramón y Cajal, Madrid, Spain. apacheco.hrc@salud.madrid.org
authors.forename: Adalberto
authors.initials: A
authors.lastname: Pacheco
authors.forename: Ignacio
authors.initials: I
authors.lastname: Cobeta
authors.forename: Carolin
authors.initials: C
authors.lastname: Wagner
mesh_terms: D002908:Chronic Disease; D003371:Cough / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006801:Humans