title: Neurodevelopmental assessment of very low birth weight preterm infants at corrected age of 18-24 months by Bayley III scales.
abstract: OBJECTIVE
  To evaluate the prevalence of delay and factors associated with neurodevelopmental scores in premature infants.
  
  
  METHODS
  Cross-sectional study to assess the development by Bayley Scales III, including very low birth weight preterm infants aged 18 to 24 months who were under follow-up at the outpatient clinic for preterm infants. Congenital malformation, genetic syndrome, symptomatic congenital infection at birth, deafness, and blindness were excluded. Numerical variables were compared by Mann-Whitney or Student t test and categorical variables by chi-square or Fisher's exact test. Factors associated with developmental scores were analyzed by linear regression, and statistical significance level was established at p < 0.05.
  
  
  RESULTS
  Out of the 58 children included, four (6.9%) presented cognitive delay, four (6.9%) motor, 17 (29.3%) language, 16 (27.6%) social-emotional and 22 (37.0%) adaptive-behavior delay. By multiple linear regression, the variables: social classes CDE (-13.27; 95%CI: -21.23 to -5.31), oxygen dependency at 36 weeks of corrected age (-8.75; 95%CI: -17.10 to -0.39) decreased the cognitive developmental score. Periventricular leukomalacia decreased the cognitive (-15.21; 95%CI: -27.61 to -2.81), motor (-10.67; 95%CI:-19.74 to -1.59) and adaptive-behavior scores (-21.52; 95%CI: -35.60 to -7.44). The female sex was associated with higher motor (10.67; 95%CI: 2.77 to 12.97), language (15.74; 95%CI: 7.39 to 24.09) and social-emotional developmental scores (10.27; 95%CI: 1.08 to 19.46).
  
  
  CONCLUSIONS
  Very low birth weight preterm infants aged from 18 to 24 months of corrected age presented more frequently language, social-emotional and adaptive-behavior delays. The variables: social classes CDE, periventricular leukomalacia, bronchopulmonary dysplasia and male sex reduced the neurodevelopmental scores.
authors.affiliation: Curso de Pós-Graduação em Pediatria e Ciências Aplicadas à Pediatria, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Luciana Volpiano
authors.initials: LV
authors.lastname: Fernandes
authors.forename: Ana Lucia
authors.initials: AL
authors.lastname: Goulart
authors.forename: Amélia Miyashiro Nunes dos
authors.initials: AM
authors.lastname: Santos
authors.forename: Marina Carvalho Moraes
authors.initials: MC
authors.lastname: Barros
authors.forename: Camila Campos
authors.initials: CC
authors.lastname: Guerra
authors.forename: Benjamin Israel
authors.initials: BI
authors.lastname: Kopelman
mesh_terms: D001938:Brazil / Q000453:epidemiology; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D003072:Cognition Disorders / Q000453:epidemiology; D003430:Cross-Sectional Studies; D002658:Developmental Disabilities / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D007805:Language Development Disorders / Q000453:epidemiology; D007969:Leukomalacia, Periventricular / Q000453:epidemiology; D016014:Linear Models; D008297:Male; D019957:Motor Skills Disorders / Q000453:epidemiology; D015995:Prevalence; D011597:Psychomotor Performance; D012307:Risk Factors; D017678:Sex Distribution; D012920:Social Behavior Disorders / Q000453:epidemiology