title: Dopamine agonists and delusional jealousy in Parkinson's disease: a cross-sectional prevalence study.
abstract: BACKGROUND
  Delusional jealousy (DJ) has been described in patients with Parkinson's disease (PD) on dopaminergic therapy, but a role for dopaminergic therapy in DJ has not been established.
  
  
  METHODS
  The current cross-sectional study on DJ investigated its association with dopaminergic therapies compared with their associations with hallucinations and its prevalence in PD patients. Eight hundred five consecutive patients with PD were enrolled between January 2009 and June 2010.
  
  
  RESULTS
  DJ was identified in 20 patients (2.48%) and hallucinations in 193 patients (23.98%). In the multivariate logistic regression analyses, dopamine agonists were significantly associated with DJ (odds ratio, 18.1; 95% CI, 3.0-infinity; P = .0002) but not with hallucinations (odds ratio, 0.73; 95% CI, 0.49-1.10; P = .133).
  
  
  CONCLUSIONS
  These findings suggest that dopamine agonist treatment represents a risk factor for DJ in PD independent of the presence of a dementing disorder, and the presence of this additional nonmotor side effect should be investigated in this clinical population.
authors.affiliation: Department of Neuroscience, University of Pisa, Pisa, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Poletti
authors.forename: Giulio
authors.initials: G
authors.lastname: Perugi
authors.forename: Chiara
authors.initials: C
authors.lastname: Logi
authors.forename: Anna
authors.initials: A
authors.lastname: Romano
authors.forename: Paolo
authors.initials: P
authors.lastname: Del Dotto
authors.forename: Roberto
authors.initials: R
authors.lastname: Ceravolo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rossi
authors.forename: Pasquale
authors.initials: P
authors.lastname: Pepe
authors.forename: Liliana
authors.initials: L
authors.lastname: Dell'Osso
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Bonuccelli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003702:Delusions / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007578:Jealousy; D016015:Logistic Models; D008297:Male; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D018491:Dopamine Agonists