title: Transforming growth factor beta-1 C-509T polymorphism and cancer risk: a meta-analysis of 55 case-control studies.
abstract: OBJECTIVE
  To investigate the association of transforming growth factor-beta 1 (TGF-β1) C-509T polymorphism and susceptibility to cancer by means of meta-analysis.
  
  
  METHODS
  An extensive search was performed to identify eligible case-control studies investigating such a link. The strength of the association between TGF-β1 C-509T polymorphism and cancer risk was assessed by pooled odds ratios (ORs) and 95%confidence intervals (95%CIs) in fixed or random effects models.
  
  
  RESULTS
  55 published case-control studies with a total number of 21,639 cases and 28,460 controls were included. Overall, there was no association between TGF-β1 C-509T and cancer risk in all genetic comparison models (TT vs. CC: OR=1.01, 95%CI=0.89-1.15; T vs. C: OR=1.01, 95%CI=0.94-1.07). However, a stratified analysis by cancer type indicated -509 T allele was significantly associated with decreased risk of colorectal cancer (CRC) (TT vs. CT/CC: OR=0.85, 95%CI=0.76-0.95), especially for Caucasians (TT vs. CT/CC: OR=0.83, 95%CI=0.71-0.98) and for population-based studies (TT vs. CT/CC: OR=0.78, 95%CI=0.68- 0.89).
  
  
  CONCLUSIONS
  This meta-analysis suggested that TGF-β1 C-509T polymorphism might contribute to a decreased risk on colorectal cancer susceptibility, especially for Caucasians.
authors.affiliation: Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China. phdwu0003@hotmail.com
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Xian-Fan
authors.initials: XF
authors.lastname: Lin
authors.forename: Chun-Jing
authors.initials: CJ
authors.lastname: Lin
authors.forename: Si-Si
authors.initials: SS
authors.lastname: Jin
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Wu
mesh_terms: D015179:Colorectal Neoplasms / Q000208:ethnology / Q000235:genetics; D016001:Confidence Intervals; D006801:Humans; D009369:Neoplasms / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D044469:Racial Groups / Q000235:genetics; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1