title: Cohort profile: the skin cancer after organ transplant study.
abstract: The Skin Cancer after Organ Transplant (SCOT) study was designed to investigate the link between genus beta human papillomavirus (HPV) and squamous cell skin cancer (SCSC). We focused on a population receiving immunosuppressive therapy for extended periods, transplant patients, as they are at extremely high risk for developing SCSC. Two complementary projects were conducted in the Seattle area: (i) a retrospective cohort with interview data from 2004 recipients of renal or cardiac transplants between 1995 and 2010 and (ii) a prospective cohort with interview data from 328 people on the transplant waiting lists between 2009 and 2011. Within the retrospective cohort, we developed a nested case-control study (172 cases and 337 control subjects) to assess risk of SCSC associated with markers of HPV in SCSC tumour tissue and eyebrow hair bulb DNA (HPV genotypes) and blood (HPV antibodies). In the prospective cohort, 135 participants had a 1-year post-transplant visit and 71 completed a 2-year post-transplant visit. In both arms of the cohort, we collected samples to assess markers of HPV infection such as acquisition of new types, proportion positive for each type, persistence of types at consecutive visits and number of HPV types detected. In the prospective cohort, we will also examine these HPV markers in relation to levels of cell-mediated immunity. The goal of the SCOT study is to use the data we collected to gain a more complete understanding of the role of immune suppression in HPV kinetics and of genus beta HPV types in SCSC. For more information, please contact the principal investigator through the study website: http://www.fhcrc.org/science/phs/cerc/The_SCOT_Study.html.
authors.affiliation: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Epidemiology, University of Washington, Seattle, WA, USA, Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Division of Dermatology, University of Washington, Seattle, WA, USA, Laboratory of Immunogenetics, Puget Sound Blood Center, Seattle, WA, USA, Division of Nephrology, University of Washington, Seattle, WA, USA and Department of Microbiology, University of Washington, Seattle, WA, USA.
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Madeleine
authors.forename: Lisa G
authors.initials: LG
authors.lastname: Johnson
authors.forename: Janet R
authors.initials: JR
authors.lastname: Daling
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Schwartz
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Carter
authors.forename: Daniel
authors.initials: D
authors.lastname: Berg
authors.forename: Karen
authors.initials: K
authors.lastname: Nelson
authors.forename: Connie L
authors.initials: CL
authors.lastname: Davis
authors.forename: Denise A
authors.initials: DA
authors.lastname: Galloway
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000276:immunology; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D016027:Heart Transplantation; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000276:immunology; D011446:Prospective Studies; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000276:immunology; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents