title: Clinical implications of coronary pressure measurement after stent implantation.
abstract: This study investigated the effect of fractional flow reserve (FFR) after stent implantation on clinical outcomes. Pressurewire measurements and follow-up data were obtained after stent implantation. Regarding the end point, target lesion revascularization (TLR) occurred in 11 patients (15.9%). Patients with TLR had higher frequencies of multiple stenting (54.5 vs. 19.0%, p = 0.01), lower post-interventional FFRs (0.84 vs. 0.88, p = 0.01), and longer stent lengths (42.20 vs. 27.69 mm, p = 0.01) than patients without TLR. The post-interventional FFR cutoff for TLR was 0.79, although this value had a weak discriminatory ability. However, multivariate analysis did not show any significant independent predictors of TLR (odds ratio 6.33; confidence interval 0.75-53.4, p = 0.09). Post-interventional FFR values were not significantly associated with TLR when a sub-analysis was performed in patients who underwent only drug-eluting stent (DES) implantation. It was difficult to achieve post-interventional FFRs of 0.9 or greater. DES implantation eliminated the effect of post-interventional FFR on TLR. Post-interventional FFR was not able to predict TLR in the present study.
authors.affiliation: Department of Cardiology, Kyoto Second Red Cross Hospital, 355-5 Haruobi-cho, Kamanzadorimarutamachi, Kamigyo-ku, Kyoto 602-8026, Japan. kiakiko@mx4.canvas.ne.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsuo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujita
authors.forename: Toru
authors.initials: T
authors.lastname: Tanigaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimonaga
authors.forename: Akira
authors.initials: A
authors.lastname: Ueoka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Tsubakimoto
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Sakatani
authors.forename: Sinzo
authors.initials: S
authors.lastname: Kimura
authors.forename: Keiji
authors.initials: K
authors.lastname: Inoue
authors.forename: Makoto
authors.initials: M
authors.lastname: Kitamura
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D023903:Coronary Restenosis; D023921:Coronary Stenosis / Q000503:physiopathology* / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D053805:Fractional Flow Reserve, Myocardial / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000706:statistics & numerical data*; D011184:Postoperative Period; D016896:Treatment Outcome