title: Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities.
abstract: Isoindole and benzoisoindole derivatives of ristocetin aglycon have been prepared by reaction with o-phthalaldehyde or naphthalene-2,3-dialdehyde and various thiols. The new compounds exhibited potent antibacterial and anti-influenza virus activity. The cluster forming and fluorescent properties of the aglycon derivatives were also studied.
authors.affiliation: Department of Pharmaceutical Chemistry, Medical and Health Science Centre, University of Debrecen, Egyetem tér 1, H-4010 Debrecen, Hungary. sipos.attila@pharm.unideb.hu
authors.forename: Attila
authors.initials: A
authors.lastname: Sipos
authors.forename: Gábor
authors.initials: G
authors.lastname: Máté
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Rőth
authors.forename: Anikó
authors.initials: A
authors.lastname: Borbás
authors.forename: Gyula
authors.initials: G
authors.lastname: Batta
authors.forename: Ilona
authors.initials: I
authors.lastname: Bereczki
authors.forename: Sándor
authors.initials: S
authors.lastname: Kéki
authors.forename: István
authors.initials: I
authors.lastname: Jóna
authors.forename: Eszter
authors.initials: E
authors.lastname: Ostorházi
authors.forename: Ferenc
authors.initials: F
authors.lastname: Rozgonyi
authors.forename: Evelien
authors.initials: E
authors.lastname: Vanderlinden
authors.forename: Lieve
authors.initials: L
authors.lastname: Naesens
authors.forename: Pál
authors.initials: P
authors.lastname: Herczegh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005453:Fluorescence; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009975:Orthomyxoviridae / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; C488135:ristocetin aglycon; D004317:Doxorubicin