title: Heat sensitive persons with multiple sclerosis are more tolerant to resistance exercise than to endurance exercise.
abstract: BACKGROUND
  Heat sensitivity (HS) is reported by 58% of all persons with multiple sclerosis (MS), causing symptom exacerbation possibly limiting exercise participation.
  
  
  OBJECTIVE
  The purpose of this study was to test the hypotheses that (a) a relationship between exercise-induced changes in core-temperature (C(temp)) and changes in symptom intensity exists, and (b) that resistance exercise (RE), as a consequence of a minor increase in core temperature, will induce a lesser worsening of symptoms than endurance exercise (EE) in HS persons with MS.
  
  
  METHODS
  On two separate days, 16 HS persons with MS randomly completed a session of RE and EE, or EE and RE, respectively. Testing was conducted pre, post and one hour after exercise and consisted of Visual Analogue Scale (VAS) scoring (fatigue, spasticity, pain, strength, walking and balance), the 5-time sit-to-stand (5STS), the Multiple Sclerosis Functional Composite (MSFC) and Body Sway. Composite scores describing average subjective symptom intensity (SI) and total number of symptoms (SN) were calculated from VAS scores.
  
  
  RESULTS
  C(temp) (0.9±0.4°C vs 0.3±0.1°C, p<0.001), SI (1.7±1.9 cm vs 0.6±1.5 cm, p<0.05) and SN (1.6±1.9 vs 0.6±2.1, p<0.05) increased significantly more during EE than RE. Changes in C(temp) correlated to changes in SI (r=0.50, p<0.01). No differences were observed in 5STS, MSFC and Body Sway scores after EE when compared to RE.
  
  
  CONCLUSIONS
  An exercise-induced increase in C(temp) is associated with increased number and severity of perceived symptoms in HS persons with MS. Based on these findings it is expected that HS persons with MS do tolerate RE better than EE.
authors.affiliation: The MS Hospitals in Ry and Haslev, Denmark. askj@sclerosehospital.dk
authors.forename: Anders G
authors.initials: AG
authors.lastname: Skjerbæk
authors.forename: Andreas B
authors.initials: AB
authors.lastname: Møller
authors.forename: Ellen
authors.initials: E
authors.lastname: Jensen
authors.forename: Kristian
authors.initials: K
authors.lastname: Vissing
authors.forename: Henrik
authors.initials: H
authors.lastname: Sørensen
authors.forename: Lars
authors.initials: L
authors.lastname: Nybo
authors.forename: Egon
authors.initials: E
authors.lastname: Stenager
authors.forename: Ulrik
authors.initials: U
authors.lastname: Dalgas
mesh_terms: D000328:Adult; D001831:Body Temperature; D015444:Exercise / Q000502:physiology*; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology; D010807:Physical Endurance / Q000502:physiology*; D055070:Resistance Training