title: Determinants of brachial-ankle pulse wave velocity in normotensive young adults with type 2 diabetes mellitus.
abstract: Brachial-ankle pulse wave velocity (baPWV) is simple, noninvasive method which correlates well with arterial stiffness. Herein, we assessed the determinants of baPWV in normotensive young adults with type 2 diabetes. We retrospectively enrolled 103 consecutive type 2 diabetic patients aged between 30 and 39 yr who measured baPWV with noninvasive pulse wave analyzer. The anthropometric parameters, blood pressure, pulse rate, fasting plasma glucose, fasting insulin, fasting C-peptide, HbA1c, lipid profile, hs-CRP, albuminuria status, AST/ALT, γ-GTP were checked concurrently. Also, we investigated history of smoking, alcohol drinking and medications by questionnaire. We found that maximal baPWV was positively correlated with mean blood pressure (r = 0.404, P < 0.001), heart rate (r = 0.285, P = 0.004), AST (r = 0.409, P < 0.001), ALT (r = 0.329, P = 0.001), γ-GTP (r = 0.273, P = 0.006), Urine albumin/creatinine ratio (r = 0.321, P = 0.003). By multiple linear regression, mean blood pressure and heart rate were significantly associated with maximal baPWV in male and total group. In female group, mean blood pressure was the only variable associated with maximal baPWV. These factors can be surrogate markers of arterial stiffness in this population.
authors.affiliation: Kim Yong Ki Internal Medicine Clinic, Busan, Korea.
authors.forename: Bo Gwang
authors.initials: BG
authors.lastname: Choi
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Kang
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Jeon
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Lee
authors.forename: In Joo
authors.initials: IJ
authors.lastname: Kim
authors.forename: Yong Ki
authors.initials: YK
authors.lastname: Kim
authors.forename: Bo Hyun
authors.initials: BH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000842:Ankle / Q000502:physiology*; D001219:Aspartate Aminotransferases / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D001916:Brachial Artery / Q000502:physiology*; D002096:C-Peptide / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008055:Lipids / Q000032:analysis; D008297:Male; D063177:Pulse Wave Analysis; D012189:Retrospective Studies; D012737:Sex Factors; D011795:Surveys and Questionnaires; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000410:Alanine Transaminase; D001219:Aspartate Aminotransferases; D002096:C-Peptide; D006442:Glycated Hemoglobin; D008055:Lipids; D005723:gamma-Glutamyltransferase; C517652:hemoglobin A1c protein, human