title: Upregulation of CBLL1 in rat brain cortex after lipopolysaccharide treated.
abstract: CBLL1 (Casitas B-lineage lymphoma-transforming sequence-like protein 1) also known as Hakai, was originally identified as an E3 ubiquitin-ligase for the E-cadherin complex. Recent data have provided evidences for novel biological functional role of CBLL1 during tumor progression and other diseases. However, its distribution and function in the central nervous system (CNS) remains unclear. In this study, we found CBLL1 was significant up-regulation in cerebral cortex after LPS administration and immunofluorescent labeling indicated that CBLL1 was localized striking in the neurons. We also investigated co-staining of CBLL1 and active-caspase-3 and cyclin D1 in the cerebral cortex following LPS administration. Based on our data, we speculated that CBLL1 might play an important role in neuronal apoptosis following LPS administration and might provide a basis for the further study on its role in cell cycle re-entry in neuroinflammation in CNS.
authors.affiliation: Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, People's Republic of China.
authors.forename: Maohong
authors.initials: M
authors.lastname: Cao
authors.forename: Heyi
authors.initials: H
authors.lastname: Zheng
authors.forename: Xiang
authors.initials: X
authors.lastname: Tan
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Rui
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Liu
authors.forename: Guangfei
authors.initials: G
authors.lastname: Xu
authors.forename: Gang
authors.initials: G
authors.lastname: Cui
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Cao
authors.forename: Kaifu
authors.initials: K
authors.lastname: Ke
authors.forename: Qiyun
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000818:Animals; D017209:Apoptosis; D015415:Biomarkers; D053148:Caspase 3 / Q000378:metabolism; D002453:Cell Cycle; D002540:Cerebral Cortex / Q000378:metabolism*; D019938:Cyclin D1 / Q000378:metabolism; D004660:Encephalitis / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D008070:Lipopolysaccharides / Q000008:administration & dosage*; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D051381:Rats; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D008070:Lipopolysaccharides; D019938:Cyclin D1; C584051:CBLL1 protein, rat; D044767:Ubiquitin-Protein Ligases; D053148:Caspase 3