title: Group- and genotype-specific neutralizing antibody responses against respiratory syncytial virus in infants and young children with severe pneumonia.
abstract: The effect of genetic variation on the neutralizing antibody response to respiratory syncytial virus (RSV) is poorly understood. In this study, acute- and convalescent-phase sera were evaluated against different RSV strains. The proportion of individuals with homologous seroconversion was greater than that among individuals with heterologous seroconversion among those infected with RSV group A (50% vs 12.5%; P = .0005) or RSV group B (40% vs 8%; P = .008). Seroconversion to BA genotype or non-BA genotype test viruses was similar among individuals infected with non-BA virus (35% vs 50%; P = .4) or BA virus (50% vs 65%; P = .4). The RSV neutralizing response is group specific. The BA-associated genetic change did not confer an ability to escape neutralizing responses to previous non-BA viruses.
authors.affiliation: KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. csande@kilifi.kemri-wellcome.org
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Sande
authors.forename: Martin N
authors.initials: MN
authors.lastname: Mutunga
authors.forename: Graham F
authors.initials: GF
authors.lastname: Medley
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Cane
authors.forename: D James
authors.initials: DJ
authors.lastname: Nokes
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011014:Pneumonia / Q000276:immunology*; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology*; D018113:Respiratory Syncytial Virus, Human / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D014759:Viral Envelope Proteins