title: Hemophagocytic lymphohistiocytosis in pregnancy: a case report and review of treatment options.
abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening inflammatory disorder characterized by uncontrolled proliferation and activation of histiocytes with phagocytosis of normal hematopoietic cells. A 41-year-old woman, 19 weeks pregnant with twins, and a history of Still's  disease, presented with rash, fever, and headache. Laboratory studies revealed transaminitis, hyperbilirubinemia, and eventually severe neutropenia as well as elevations in ferritin, lactate dehydrogenase, and C-reactive protein. A bone marrow biopsy confirmed HLH. She declined standard HLH-treatment  but responded well to high-dose corticosteroids. Her blood counts remained stable following corticosteroid taper, and she delivered healthy twin girls at 30-week gestation. Few cases of HLH during pregnancy have been reported. In some cases, the condition has proved fatal. Therefore recognizing  signs and symptoms of HLH is essential to avoid treatment delay. In our case, high-dose corticosteroids alone were a safe and effective therapy for the mother and fetuses resulting in long-term disease control.
authors.affiliation: Stanford University, School of Medicine, Stanford, CA 94027, USA.
authors.forename: Tamara
authors.initials: T
authors.lastname: Dunn
authors.forename: May
authors.initials: M
authors.lastname: Cho
authors.forename: Bruno
authors.initials: B
authors.lastname: Medeiros
authors.forename: Aaron
authors.initials: A
authors.lastname: Logan
authors.forename: Alexander
authors.initials: A
authors.lastname: Ungewickell
authors.forename: Michaela
authors.initials: M
authors.lastname: Liedtke
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000188:drug therapy; D010587:Phagocytosis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000188:drug therapy