title: Relationship between surface properties determined by inverse gas chromatography and ibuprofen release from hybrid materials based on fumed silica.
abstract: The ability of organic-inorganic hybrid materials to act as drug release-modifying agents was examined. In this study, ibuprofen, a non-steroidal anti-inflammatory drug was used as a model active pharmaceutical ingredient. The physicochemical properties of individual components of the hybrids, as well as these for two- and three-component systems were examined by inverse gas chromatography. The dispersive component of the free surface energy (γ(S)(D)), K(A) and K(D) parameters describing acidity and basicity of hybrid materials, respectively, as well as Flory-Huggins parameters were determined. χ(12)(∞) and [Formula: see text] parameters characterize the interactions between the hybrids and a test solute, or interactions between the drug and inorganic-organic materials, respectively. Additionally, Brunauer-Emmett-Teller (BET) method was used to characterize adsorption activity of the studied materials. The prepared hybrid materials were also characterized by Fourier transform infra-red (FTIR) spectroscopy. The release profiles of ibuprofen for the created hybrid materials were determined. Relationship between the physicochemical activity of hybrid materials and ibuprofen release was presented and discussed.
authors.affiliation: Poznan University of Technology, Institute of Chemical Technology and Engineering, Pl. M. Skłodowskiej-Curie 2, 60-965 Poznan, Poland. joannakolo@op.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Kołodziejek
authors.forename: Eliza
authors.initials: E
authors.lastname: Główka
authors.forename: Kinga
authors.initials: K
authors.lastname: Hyla
authors.forename: Adam
authors.initials: A
authors.lastname: Voelkel
authors.forename: Janina
authors.initials: J
authors.lastname: Lulek
authors.forename: Kasylda
authors.initials: K
authors.lastname: Milczewska
mesh_terms: D000327:Adsorption; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002849:Chromatography, Gas / Q000379:methods*; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012822:Silicon Dioxide; D007052:Ibuprofen