title: Prognostic values of serum tenascin-C in patients with ischaemic heart disease and heart failure.
abstract: OBJECTIVE
  The aim of this study was to evaluate the prognostic values of serum tenascin-C in patients with heart failure and ischaemic heart disease.
  
  
  METHODS
  Serum tenascin-C levels were assessed in 83 patients with heart failure and in 30 healthy subjects. The correlations between serum tenascin-C levels and left ventricular ejection fraction, serum B-type natriuretic peptide and procollagen III were analysed. Patients were followed up for 12 months, and the relations between the serum levels of tenascin-C and cardiac events (re-hospitalisation for worsening heart failure and mortality) were analysed.
  
  
  RESULTS
  Serum tenascin-C levels in patients with heart failure were higher than in healthy volunteers (72.24 ± 11.02 vs. 22.78 ± 2.51 μg/L, p<0.01). Serum tenascin-C levels in patients of NYHA class IV were higher than in patients with NYHA class II (88.56 ± 3.73 vs. 64.88 ± 3.15 μg/L, p<0.01). The levels of tenascin-C were negatively correlated with the left ventricular ejection fraction (r=-0.636, p<0.01), but were positively correlated with serum B-type natriuretic peptide (r=0.553, p<0.01) or procollagen III levels (r=0.665, p<0.01). An increased level of tenascin-C was an independent predictor for combined re-hospitalisation and mortality (OR 1.22, 95% CI: 0.86-2.14).
  
  
  CONCLUSIONS
  Serum tenascin-C levels were elevated in patients with heart failure. The levels of tenascin-C were associated with the severity of left ventricular dysfunction and 12-month major adverse cardiac events.
authors.affiliation: Department of Cardiology, Liaocheng People's Hospital of Taishan Medical University, Shandong Province 252000, China.
authors.forename: Heng-Chen
authors.initials: HC
authors.lastname: Yao
authors.forename: Qian-Feng
authors.initials: QF
authors.lastname: Han
authors.forename: Ai-Ping
authors.initials: AP
authors.lastname: Zhao
authors.forename: Dao-Kuo
authors.initials: DK
authors.lastname: Yao
authors.forename: Le-Xin
authors.initials: LX
authors.lastname: Wang
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D024061:Collagen Type III / Q000097:blood; D016001:Confidence Intervals; D018450:Disease Progression; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications; D020097:Natriuretic Peptide, Brain / Q000097:blood; D016017:Odds Ratio; D010359:Patient Readmission; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012720:Severity of Illness Index; D013318:Stroke Volume; D019063:Tenascin / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D024061:Collagen Type III; D019063:Tenascin; D020097:Natriuretic Peptide, Brain