title: Effects of oral administration of fucoidan extracted from Cladosiphon okamuranus on tumor growth and survival time in a tumor-bearing mouse model.
abstract: We evaluated the anti-tumor activities of the oral administration of fucoidan extracted from Cladosiphon okamuranus using a tumor (colon 26)-bearing mouse model. The materials used included low-molecular-weight fucoidan (LMWF: 6.5-40 kDa), intermediate-molecular-weight fucoidan (IMWF: 110-138 kDa) and high-molecular-weight fucoidan (HMWF: 300-330 kDa). The IMWF group showed significantly suppressed tumor growth. The LMWF and HMWF groups showed significantly increased survival times compared with that observed in the control group (mice fed a fucoidan-free diet). The median survival times in the control, LMWF, IMWF and HMWF groups were 23, 46, 40 and 43 days, respectively. It was also found that oral administration of fucoidan increased the population of natural killer cells in the spleen. Furthermore, from the results of the experiment using Myd-88 knockout mice, it was found that these effects are related to gut immunity. These results suggest that fucoidan is a candidate anti-tumor functional food.
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Azuma
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan.
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Ishihara
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamoto
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Amaha
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Osaki
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuka
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Imagawa
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan.
authors.forename: Saburo
authors.initials: S
authors.lastname: Minami
authors.affiliation: Scientific Crime Laboratory, Tottori Prefectural Police H. Q., 2-12 Chiyomi, Tottori 680-0911, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Takashima
authors.affiliation: The Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ifuku
authors.affiliation: The Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Morimoto
authors.affiliation: The Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saimoto
authors.affiliation: Marine Products Kimura Co., LTD., 3307 Watari-cho Sakaiminato-shi, Tottori 684-0072, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kawamoto
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000517:prevention & control; D005260:Female; D020287:In Situ Nick-End Labeling; D007694:Killer Cells, Natural / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics / Q000378:metabolism; D000459:Phaeophyceae / Q000737:chemistry*; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D013154:Spleen
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; D011134:Polysaccharides; C007789:fucoidan