title: Effect of dexmedetomidine on erythrocyte deformability during ischemia-reperfusion injury of liver in diabetic rats.
abstract: OBJECTIVE
  The aim of this study is to evaluate the effect of dexmedetomidine on erythrocyte deformability during IR injury of liver in diabetic rats.
  
  
  METHODS
  Twenty- eight Wistar Albino rats were included in the study after a 4 week streptozocin (65 mg/kg) treatment to observe the existence of diabetes. The animals were randomly assigned to one of the four experimental groups: GroupC and DC (sham-control group): The abdomen was dissected with a median laparotomy and the liver was collected. GroupDIR: The liver was collected after IR following the abdominal median laparotomy. GroupDIRD: The liver was collected after IR following the abdominal median laparotomy and 30 min of infusion of dexmedetomidine 100 µg/kg ip The deformability measurements were performed in erythrocyte suspensions containing Htc 5% in PBS buffer.
  
  
  RESULTS
  The deformability index was significantly increased in diabetic rats, however it was similar in the GroupC and DIRD. It was significantly increased in the GroupDIR when compared to the GroupC, DIRD and DC. The relative resistance was increased in IR models.
  
  
  CONCLUSIONS
  Erythrocyte deformability was damaged in rats having diabetes and IR injury. This injury might lead to further problems in microcirculation. It was shown that dexmedetomidine may be useful in enhancing the adverse effects of this injury (Tab. 1, Fig. 2, Ref. 41).
authors.affiliation: Department of Anaesthesiology and Reanimation, Gazi University Medical Faculty, Ankara, Turkey. marslan36@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Arslan
authors.forename: F M
authors.initials: FM
authors.lastname: Comu
authors.forename: B
authors.initials: B
authors.lastname: Isik
authors.forename: L
authors.initials: L
authors.lastname: Ozturk
authors.forename: E
authors.initials: E
authors.lastname: Kesimci
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000494:pharmacology*; D000818:Animals; D020927:Dexmedetomidine / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000150:complications; D004907:Erythrocyte Deformability / Q000187:drug effects*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008099:Liver / Q000098:blood supply*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood* / Q000150:complications
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine