title: Erythema nodosum leprosum and reversal reaction in 2 cases of imported leprosy.
abstract: Leprosy reactions, which are abrupt changes in the clinical condition of patients with immunologically unstable forms of the disease, can mask the cardinal signs of leprosy, delaying both diagnosis and treatment. The main complications that arise from delayed diagnosis reflect the characteristic features of the disease, involving impaired nerve function and both local (ulcers, pyogenic infection, osteomyelitis) and systemic compromise. Through clinical examination, sensory testing, and, where necessary, histopathology and microbiology, are essential when leprosy is suspected. Rapid initiation of anti-inflammatory treatment reduces the risk of functional impairment, the main concern in leprosy. We describe type 1 and type 2 leprosy reactions in 2 patients who had not yet been diagnosed with the disease.
authors.affiliation: Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address: ana.pulido@madrimasd.net.
authors.forename: A
authors.initials: A
authors.lastname: Pulido-Pérez
authors.forename: M D
authors.initials: MD
authors.lastname: Mendoza-Cembranos
authors.forename: J A
authors.initials: JA
authors.lastname: Avilés-Izquierdo
authors.forename: R
authors.initials: R
authors.lastname: Suárez-Fernández
mesh_terms: D000328:Adult; D004893:Erythema Nodosum / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D015440:Leprosy, Lepromatous / Q000175:diagnosis* / Q000276:immunology; D008297:Male