title: Resistin levels in women with ischemic stroke.
abstract: OBJECTIVE
  Resistin may be an independent inflammatory marker of atherosclerosis. Therefore, its circulating level might be important prognostic factor of cardiovascular disease in humans. We aimed in this study to assess plasma resistin concentration in Polish women with acute ischemic stroke, who additionally suffer from chronic diseases: diabetes, hypertension and/or obesity. The changes of resistin levels after 10 days from the onset of stroke and possible associations between resistin and pro-inflammatory cytokine TNFα were also evaluated.
  
  
  METHODS
  Material consisted of 41 women with ischemic stroke (aged 60-85 years) and 64 controls (aged 60-85 years). Circulating resistin and TNFα concentrations were measured using ELISA. Blood was taken twice in the stroke group, in the first and tenth day from the onset of clinical symptoms, and only once in the controls. Clinical and biochemical data (blood pressure, weight, height, glucose, insulin, lipid profile) were collected.
  
  
  RESULTS
  Higher concentrations of resistin and TNFα were observed in ischemic stroke patients at the first day comparing to the controls. Second evaluation after 10 days in comparison with the first measurement revealed significantly higher TNFα levels and non-significant lower values of resistin. Resistin positively correlated with TNFα and stroke severity.
  
  
  CONCLUSIONS
  Changes in resistin and TNFα concentrations were observed in the course of stroke. Further investigations are required to assess the implication of these findings. Higher resistin concentration might be associated with worse neurological deficits.
authors.affiliation: Department of Neurology, Warsaw Medical University, Warsaw, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Kochanowski
authors.forename: Mariusz
authors.initials: M
authors.lastname: Grudniak
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Baranowska-Bik
authors.forename: Ewa
authors.initials: E
authors.lastname: Wolinska-Witort
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Kalisz
authors.forename: Boguslawa
authors.initials: B
authors.lastname: Baranowska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Bik
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D052243:Resistin / Q000097:blood* / Q000276:immunology; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; C499624:RETN protein, human; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha