title: Targeting genetic alterations in protein methyltransferases for personalized cancer therapeutics.
abstract: The human protein methyltransferases (PMTs) constitute a large enzyme class composed of two families, the protein lysine methyltransferases (PKMTs) and the protein arginine methyltransferases (PRMTs). Examples have been reported of both PKMTs and PRMTs that are genetically altered in specific human cancers, and in several cases these alterations have been demonstrated to confer a unique dependence of the cancer cells on PMT enzymatic activity for the tumorigenic phenotype. Examples of such driver alterations in PMTs will be presented together with a review of current efforts towards the discovery and development of small-molecule inhibitors of these enzymes as personalized cancer therapeutics.
authors.affiliation: R&D Epizyme, Inc., Cambridge, MA 02139, USA. RCopeland@Epizyme.com
authors.forename: R A
authors.initials: RA
authors.lastname: Copeland
authors.forename: M P
authors.initials: MP
authors.lastname: Moyer
authors.forename: V M
authors.initials: VM
authors.lastname: Richon
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000494:pharmacology; D057890:Epigenomics; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000235:genetics; D057285:Precision Medicine / Q000379:methods*; D011496:Protein Methyltransferases / Q000037:antagonists & inhibitors* / Q000235:genetics* / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D011496:Protein Methyltransferases