title: Functional and molecular insights into KSRP function in mRNA decay.
abstract: KSRP is a single strand nucleic acid binding protein that controls gene expression at multiple levels. In this review we focus on the recent molecular, cellular, and structural insights into the mRNA decay promoting function of KSRP. We discuss also some aspects of KSRP-dependent microRNA maturation from precursors that are related to its mRNA destabilizing function. This article is part of a Special Issue entitled: RNA Decay mechanisms.
authors.affiliation: IRCCS Azienda Ospedaliera Universitaria San Martino, Genova, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Briata
authors.forename: Ching-Yi
authors.initials: CY
authors.lastname: Chen
authors.forename: Andres
authors.initials: A
authors.lastname: Ramos
authors.forename: Roberto
authors.initials: R
authors.lastname: Gherzi
mesh_terms: D001665:Binding Sites; D002460:Cell Line; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020871:RNA Stability / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics*
chemical_list: C105789:KHSRP protein, human; D035683:MicroRNAs; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D015534:Trans-Activators