title: Science to practice: a new insight into nephrotoxicity after contrast medium administration.
abstract: Liu et al (1) have shown that iodinated contrast medium preferentially vasoconstricts the glomerular afferent arterioles by depleting endothelial nitric oxide bioavailability. This potentiates an exaggerated afferent arteriolar vasoconstricting response to angiotensin II and opens possibilities for new methods to prevent or treat nephrotoxicity after contrast medium administration.
authors.affiliation: Cornell MRI, Cornell-Weill Medical College, 416 E 55th St, New York, NY 10022, USA. map2008@med.cornell.edu
authors.forename: Martin R
authors.initials: MR
authors.lastname: Prince
authors.forename: Honglei
authors.initials: H
authors.lastname: Zhang
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Newhouse
mesh_terms: D000818:Animals; D001160:Arterioles / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D008297:Male; D014283:Triiodobenzoic Acids / Q000494:pharmacology*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol