title: Giant-cell myocarditis complicated by heparin-induced thrombocytopenia.
abstract: Giant-cell myocarditis is a fatal autoimmune disorder that is often associated with other autoimmune diseases. We herein describe a case of giant-cell myocarditis complicated by heparin-induced thrombocytopenia (HIT). A 71-year-old woman was admitted to our hospital due to palpitations and ptosis. Echocardiography revealed hypokinesis in the left basal ventricular walls. Heart failure gradually developed, and the condition was complicated by HIT. The patient died of cardiogenic and septic shock caused by agranulocytosis. An autopsy showed giant-cell myocarditis. When severe left ventricular dysfunction due to an unknown cause is complicated by HIT, potential diagnoses of giant-cell and other types of autoimmune myocarditis should thus be investigated.
authors.affiliation: Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Morita
authors.forename: Naoki
authors.initials: N
authors.lastname: Oka
authors.forename: Kazushige
authors.initials: K
authors.lastname: Kadota
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Goto
authors.forename: Satoki
authors.initials: S
authors.lastname: Fujii
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Harumi
authors.initials: H
authors.lastname: Katoh
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fuku
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Hirono
authors.forename: Takeshi
authors.initials: T
authors.lastname: Maruo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Seiji
authors.initials: S
authors.lastname: Habara
authors.forename: Tahei
authors.initials: T
authors.lastname: Ichinohe
authors.forename: Kenji
authors.initials: K
authors.lastname: Notohara
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Mitsudo
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D017809:Fatal Outcome; D005260:Female; D015726:Giant Cells / Q000473:pathology; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D009205:Myocarditis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications*
chemical_list: D006493:Heparin