title: MTNR1A receptor expression in normal and pathological human salivary glands.
abstract: OBJECTIVE
  To analyze and compare the expression of MTNR1A receptor in normal and pathological major and minor salivary glands.
  
  
  METHODS
  Twenty samples of major and minor salivary glands and 10 with Warthin's tumor were studied. Expression of the MTNR1A receptor (goat polyclonal antibody raised against a peptide mapping at the N-terminus of MEL-1A R of human origin) was analyzed.
  
  
  RESULTS
  The excretory ducts of major salivary glands demonstrated intense intracytoplasmic positivity but scant cytoplasmic membrane positivity for MTNR1A. The studied Warthin's tumors showed intense cytoplasmic positivity for MT1 receptor in all cylindrical epithelial cells lining spaces and a less intense positivity in basal cells. The lymphoid component accompanying the tumor was negative for MT1 receptor.
  
  
  CONCLUSIONS
  Intense intracytoplasmic positivity for the MTNR1A receptor in the excretory ducts of human major and minor salivary glands and Warthin's tumor was found. The intense expression of MTNR1A receptors observed in this study in the excretory ducts of major and minor salivary glands may be related to salivary regulation.
authors.affiliation: Department of Pathology, San Cecilio University Hospital, Granada, Spain. salvadorarias@hotmail.es
authors.forename: Salvador
authors.initials: S
authors.lastname: Arias-Santiago
authors.forename: José
authors.initials: J
authors.lastname: Aneiros-Fernández
authors.forename: Borja
authors.initials: B
authors.lastname: Arias-Santiago
authors.forename: María Sierra
authors.initials: MS
authors.lastname: Girón-Prieto
authors.forename: Mercedes
authors.initials: M
authors.lastname: Caba-Molina
authors.forename: Antonio
authors.initials: A
authors.lastname: López-Valverde
authors.forename: José
authors.initials: J
authors.lastname: Aneiros-Cachaza
authors.forename: Antonio
authors.initials: A
authors.lastname: Campos
authors.forename: Antonio
authors.initials: A
authors.lastname: Cutando
mesh_terms: D000235:Adenolymphoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis; D044122:Receptor, Melatonin, MT1 / Q000032:analysis / Q000096:biosynthesis*; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D012469:Salivary Glands / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D044122:Receptor, Melatonin, MT1