title: [Use of zebrafish models for the research of traditional Chinese medicine].
abstract: Traditional Chinese medicine (TCM) exhibits a broad range of effects on biological activity that is probably due to interactions of complex chemical constituents with multiple targets in the body. Understanding the active chemical constituents in TCM is very important in providing rationales for the clinical usage of TCM. The zebrafish (Danio rerio) has recently become a popular model in the field of drug screening, specifically emerging as an important vertebrate model for in vivo high-content drug screening of multiple efficacy parameters and whole-organism toxicity. The authors also discussed the advantages of the zebrafish model for evaluating drug metabolism. Zebrafish usage in TCM screening should be a viable approach that helps identify active chemical markers, biological pathways and mechanistic actions of TCM.
authors.affiliation: Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: You-hua
authors.initials: YH
authors.lastname: Wang
authors.forename: Shang
authors.initials: S
authors.lastname: Li
authors.forename: Bin-rui
authors.initials: BR
authors.lastname: Yang
authors.forename: Lun-qing
authors.initials: LQ
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Pui-man
authors.initials: PM
authors.lastname: Hoi
authors.forename: Simon Ming-yuen
authors.initials: SM
authors.lastname: Lee
mesh_terms: D000818:Animals; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D008516:Medicine, Chinese Traditional; D008954:Models, Biological; D015027:Zebrafish