title: Prevalence of thrombosis-related DNA polymorphisms in a healthy Greek population.
abstract: Genetic association studies have revealed a correlation between DNA variations in genes encoding factors of the haemostatic system and thrombosis-related disease. This study investigated the prevalence of 13 such genetic risk factors in a sample (N=400 alleles) of the Hellenic population of Greece. Some of these polymorphisms [coagulation factor V (F5) Leiden, coagulation factor II (F2) G20210A, 5,10-methylene tetrahydrofolate reductase (MTHFR) C677T, coagulation factor XIII A1 subunit (F13A1) Val34Leu, serpine1 (SERPINE1) 4G/5G, angiotensin I-converting enzyme (ACE) I/D, angiotensinogen (AGT) Met325Thr, integrin A2 (ITGA2) C807T] have been previously studied in Hellenic populations of Greece and Cyprus, while others such as coagulation factor XII (F12) C46T, plasma carboxypeptidase B2 (CPB2) C1040T, platelet glycoprotein Ib α polypeptide (GP1BA) VNTR, thrombomodulin (THBD) -A33G and protein Z (PROZ) - A13G have not. Most of the allelic frequencies observed are similar to those reported for other Southern European populations. Knowledge of the prevalence of these variations in a given population may assist in the design of effective preventive measures against cardiovascular disease.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Athens, Greece. cyapijakis_ua_gr@yahoo.com
authors.forename: Christos
authors.initials: C
authors.lastname: Yapijakis
authors.forename: Zoe
authors.initials: Z
authors.lastname: Serefoglou
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Nixon
authors.forename: Antonis
authors.initials: A
authors.lastname: Vylliotis
authors.forename: Vassilis
authors.initials: V
authors.lastname: Ragos
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Vairaktaris
mesh_terms: D015415:Biomarkers / Q000097:blood*; D003535:Cyprus; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006115:Greece; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D013927:Thrombosis / Q000097:blood / Q000235:genetics / Q000473:pathology
chemical_list: D015415:Biomarkers