title: Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity.
abstract: Whereas some rare lipids contribute to the identity of cell organelles, we focus on the abundant lipids that form the matrix of organelle membranes. Observations using bioprobes and peripheral proteins, notably sensors of membrane curvature, support the prediction that the cell contains two broad membrane territories: the territory of loose lipid packing, where cytosolic proteins take advantage of membrane defects, and the territory of electrostatics, where proteins are attracted by negatively charged lipids. The contrasting features of these territories provide specificity for reactions occurring along the secretory pathway, on the plasma membrane, and also on lipid droplets and autophagosomes.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia Antipolis et CNRS, 06560 Valbonne, France.
authors.forename: Joëlle
authors.initials: J
authors.lastname: Bigay
authors.forename: Bruno
authors.initials: B
authors.lastname: Antonny
mesh_terms: D000818:Animals; D006801:Humans; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D015388:Organelles / Q000737:chemistry* / Q000378:metabolism; D010587:Phagocytosis; D055672:Static Electricity
chemical_list: D008563:Membrane Lipids; D008565:Membrane Proteins