title: Combinatorial Immunotherapy: PD-1 may not be LAG-ing behind any more.
abstract: Cancer immunotherapy attempts to harness the immune system by breaking tolerance and generating a robust anticancer response. We have recently demonstrated a synergistic enhancement in tumor clearance following therapeutic, dual PD-1 and LAG-3 blockade. Here, we discuss the implications of these findings in the context of future combinatorial immunotherapeutic approaches.
authors.affiliation: Department of Immunology; St. Jude Children`s Research Hospital; Memphis, TN USA.
authors.forename: Meghan E
authors.initials: ME
authors.lastname: Turnis
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Korman
authors.forename: Charles G
authors.initials: CG
authors.lastname: Drake
authors.forename: Dario A A
authors.initials: DA
authors.lastname: Vignali