title: [Peripheral muscle dysfunction in chronic obstructive pulmonary disease].
abstract: Although primarily a disease of the lungs, Chronic Obstructive Pulmonary Disease (COPD) associates systemic manifestations and comorbidities. The skeletal muscles function is restricted in COPD, because of decreased endurance and strength. Skeletal muscle weakness has a great clinical importance in COPD, as it is recognized to contribute independently to poor health status, reduced quality of life and increased mortality. The purpose of this paper is to describe the current knowledge of the structural and functional abnormalities of skeletal muscles in COPD and the possible physiopathologic determination of these dysfunctions. The understanding of these abnormalities is essential in development of new therapeutic strategies to combat muscle dysfunction in COPD, including the pulmonary rehabilitation programs.
authors.affiliation: Universitatea de Medicină si Farmacie "Grigore T. Popa" Iaşi, Facultatea de Medicină, Spitalul Clinic de Pneumologie Iaşi. mihai.roca@d.umfiasi.ro
authors.forename: Mihai
authors.initials: M
authors.lastname: Roca
authors.forename: Traian
authors.initials: T
authors.lastname: Mihăescu
mesh_terms: D005081:Exercise Therapy / Q000379:methods; D006801:Humans; D006935:Hypercapnia / Q000150:complications; D000860:Hypoxia / Q000150:complications; D007249:Inflammation / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009135:Muscular Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D009748:Nutrition Disorders / Q000150:complications; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000378:metabolism / Q000503:physiopathology* / Q000534:rehabilitation*; D011788:Quality of Life; D012132:Respiratory Muscles / Q000503:physiopathology*; D012138:Respiratory Therapy / Q000379:methods; D012307:Risk Factors; D016896:Treatment Outcome