title: Acute kidney injury requiring hemodialysis in the tropics.
abstract: The morbidity and mortality from acute kidney injury (AKI) have remained relatively high over the last six decades. The triad of infections, nephrotoxins and obstetric complications are still major causes of acute kidney injury in the tropics. This retrospective study is a five-year audit of acute renal failure (ARF) (or stage 3 AKI) in patients requiring hemodialysis at the renal unit of the Department of Medicine of the Ladoke Akintola University of Technology (LAUTECH) Teaching Hospital, Osogbo, Nigeria. A total of 80 patients with AKI were treated over a five-year period at our center, of which 45 (56.2%) were in ARF, i.e. stage 3 AKI requiring hemodialysis. There were 24 males and 21 females. The most common cause of ARF among the patients was sepsis syndrome 16 (35.5%), while pregnancy-related cases accounted for 15 (33.3%) and nephrotoxins for 6 (13.3%). Five (33%) of the 15 pregnancy-related patients survived, and all were cases of septic abortion. Of the other 10 patients that did not survive, three (30%) had post-partum hemorrhage and seven (70%) post-partum eclampsia. In all, the mortality rate among our AKI presenting for hemodialysis at our center over a given year period was 28.8%. Majority of these were eclampsia related. The causes of ARF still remain the same in the tropics, eclampsia portends poor prognosis. Concerted efforts should be made at limiting this trend by active preventive services and early recognition of high-risk obstetrics cases.
authors.affiliation: Department of Medicine, Ladoke Akintola University of Technology, Osogbo, Nigeria. yok8t@yahoo.com
authors.forename: Oluyomi O
authors.initials: OO
authors.lastname: Okunola
authors.forename: Olugbenga E
authors.initials: OE
authors.lastname: Ayodele
authors.forename: Adebode D
authors.initials: AD
authors.lastname: Adekanle
mesh_terms: D000031:Abortion, Septic / Q000209:etiology; D058186:Acute Kidney Injury / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D004461:Eclampsia / Q000209:etiology; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D006473:Postpartum Hemorrhage / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D006435:Renal Dialysis / Q000009:adverse effects / Q000401:mortality; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D018746:Systemic Inflammatory Response Syndrome / Q000150:complications; D013997:Time Factors; D016896:Treatment Outcome; D014329:Tropical Climate; D055815:Young Adult