title: Selective soil particle adherence to hands: implications for understanding oral exposure to soil contaminants.
abstract: Over the last 30 years, there has been extensive research designed to quantify the extent of oral bioavailability and bioaccessibility of organic and inorganic contaminants in soil. One aspect of this research is the soil particle size selected to represent environmental exposures, which may affect study results and comparability across studies. Different research groups have studied soil particle sizes ranging from <45 μm to <2000 μm. This article reviews the historical and technical considerations that pertain to the selection of an appropriate particle size fraction for evaluating the relative oral bioavailability of chemicals from soil, which include (1) how the resultant data will be used in human health risk assessment, (2) soil fractions historically used in oral bioavailability studies, (3) studies of soil adherence to human hands, (4) the distribution of contaminants in soils as a function of particle size, and (5) the effect of differential bioavailability as a function of soil particle size and geochemical matrix. These factors are first discussed from a general perspective, applicable to all contaminants in soil, and then more specifically for polycyclic aromatic hydrocarbons (PAHs) in soil. Based on this review, a specific soil particle size of <150 μm is recommended for future studies on the oral bioavailability and bioaccessibility of PAHs in soil.
authors.affiliation: Integral Consulting Inc., 285 Century Place, Suite 190, Louisville, Colorado 80027, USA. mruby@integral-corp.com
authors.forename: Michael V
authors.initials: MV
authors.lastname: Ruby
authors.forename: Yvette W
authors.initials: YW
authors.lastname: Lowney
mesh_terms: D004781:Environmental Exposure / Q000032:analysis* / Q000266:history; D006225:Hand / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D010316:Particle Size; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis* / Q000378:metabolism; D012987:Soil / Q000032:analysis; D012989:Soil Pollutants / Q000032:analysis* / Q000378:metabolism
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; D012987:Soil; D012989:Soil Pollutants