title: Contribution to investigation of antimicrobial activity of styrylquinolines.
abstract: Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed.
authors.affiliation: Institute of Chemistry, University of Silesia, PL-40006 Katowice, Poland.
authors.forename: Wioleta
authors.initials: W
authors.lastname: Cieslik
authors.forename: Robert
authors.initials: R
authors.lastname: Musiol
authors.forename: Jacek E
authors.initials: JE
authors.lastname: Nycz
authors.forename: Josef
authors.initials: J
authors.lastname: Jampilek
authors.forename: Marcela
authors.initials: M
authors.lastname: Vejsova
authors.forename: Mariusz
authors.initials: M
authors.lastname: Wolff
authors.forename: Barbara
authors.initials: B
authors.lastname: Machura
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Polanski
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D006846:Hydrocarbons, Halogenated; D011804:Quinolines; C481600:styrylquinoline