title: Radiation-induced fibrosarcoma after radiotherapy for osteosarcoma in the mandibular condyle.
abstract: With recent improvements in survival duration after cancer treatment, it is becoming increasingly important to study treatment-related morbidity and mortality. Radiation-induced sarcomas in the irradiated field are well-known potential late sequelae of radiotherapy. These tumors are biologically aggressive. In the case described here, a radiation-induced fibrosarcoma appeared at 20 years after initial surgery, radiotherapy, and chemotherapy for an osteosarcoma of the mandibular condyle. Radiation-induced fibrosarcoma is relatively rare in the head and neck region. The details of this case are presented, and diagnostic and management considerations are described.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan. madachi_dds_phd@yahoo.co.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Adachi
authors.forename: Toshinori
authors.initials: T
authors.lastname: Iwai
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirota
authors.forename: Iwai
authors.initials: I
authors.lastname: Tohnai
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D001932:Brain Neoplasms / Q000556:secondary; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D005354:Fibrosarcoma / Q000175:diagnosis*; D006801:Humans; D008335:Mandibular Condyle / Q000528:radiation effects*; D008339:Mandibular Neoplasms / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis*; D012516:Osteosarcoma / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed