title: Chemical detoxification of small molecules by Caenorhabditis elegans.
abstract: Caenorhabditis elegans lives in compost and decaying fruit, eats bacteria and is exposed to pathogenic microbes. We show that C. elegans is able to modify diverse microbial small-molecule toxins via both O- and N-glucosylation as well as unusual 3'-O-phosphorylation of the resulting glucosides. The resulting glucosylated derivatives have significantly reduced toxicity to C. elegans, suggesting that these chemical modifications represent a general mechanism for worms to detoxify their environments.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Stupp
authors.forename: Stephan H
authors.initials: SH
authors.lastname: von Reuss
authors.forename: Yevgeniy
authors.initials: Y
authors.lastname: Izrayelit
authors.forename: Ramadan
authors.initials: R
authors.lastname: Ajredini
authors.forename: Frank C
authors.initials: FC
authors.lastname: Schroeder
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Edison
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D017173:Caenorhabditis elegans / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D010619:Phenazines / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D010619:Phenazines; D054852:Small Molecule Libraries