title: Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids.
abstract: We investigated the penetration and thermotherapy efficiency of different surface coated gold nanorods (Au NRs) in multicellular tumor spheroids. The current data show that negatively charged Au NRs, other than positively charged Au NRs, can penetrate deep into the tumor spheroids and achieve a significant thermal therapeutic benefit.
authors.affiliation: Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, Beijing, China.
authors.forename: Shubin
authors.initials: S
authors.lastname: Jin
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Ma
authors.forename: Huili
authors.initials: H
authors.lastname: Ma
authors.forename: Kaiyuan
authors.initials: K
authors.lastname: Zheng
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Shuai
authors.initials: S
authors.lastname: Hou
authors.forename: Jie
authors.initials: J
authors.lastname: Meng
authors.forename: Paul C
authors.initials: PC
authors.lastname: Wang
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Wu
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D004058:Diffusion; D006046:Gold / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D061986:MCF-7 Cells; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D018874:Spheroids, Cellular / Q000737:chemistry* / Q000187:drug effects*; D055672:Static Electricity; D013499:Surface Properties; D016896:Treatment Outcome
chemical_list: D006046:Gold