title: Comparing statistics for objective detection of transient and steady-state evoked responses in newborns.
abstract: OBJECTIVE
  Receiver operating characteristic (ROC) methodology was used to compare the performance of different statistics in the automatic detection of multiple auditory steady-state responses (MSSR) and click auditory brainstem responses (cABR).
  
  
  METHODS
  Thirty-five healthy newborns tested within the first two weeks of birth.
  
  
  METHODS
  In each case cABR and MSSR (0.5 and 2 kHz) were recorded with and without acoustic stimulation, using AUDIX equipment. With this test sample of recordings, ROC curves were evaluated separately for each statistic evaluated: (1) the standard deviation ratio (SDR) and the correlation coefficient ratio (CCR) for the cABR; (2) the Hotelling T2 (HT2) and circular T2 (CT2) for the MSSR.
  
  
  RESULTS
  All objective detection methods performed well (areas under ROC (AUC) > 0.9). The MSSR statistics showed significantly larger AUCs at both frequencies (HT2: 0.98 and 1; CT2: 0.96 and 0.99) than the cABR measures (SDR: 0.91 and CCR: 0.92). The HT2 hits rate was the highest (97-100% at 0.5 and 2 kHz) for fixed false alarms rates of both 10 and 20%.
  
  
  CONCLUSIONS
  This superiority of performance of T2-like statistics, reflecting inherent advantages of MSSR analysis for automation, warrants serious consideration for further development of newborn screening technology.
authors.affiliation: Cuban Neurosciences Center, Havana, Cuba. eleina.mijares@cneuro.edu.cu
authors.forename: Eleina
authors.initials: E
authors.lastname: Mijares
authors.forename: María Cecilia
authors.initials: MC
authors.lastname: Pérez Abalo
authors.forename: Didiesdle
authors.initials: D
authors.lastname: Herrera
authors.forename: Agustin
authors.initials: A
authors.lastname: Lage
authors.forename: Mayrim
authors.initials: M
authors.lastname: Vega
mesh_terms: D000161:Acoustic Stimulation; D019540:Area Under Curve; D001331:Automation; D003627:Data Interpretation, Statistical; D004569:Electroencephalography / Q000706:statistics & numerical data*; D016057:Evoked Potentials, Auditory, Brain Stem; D006320:Hearing Tests / Q000706:statistics & numerical data*; D006801:Humans; D007231:Infant, Newborn; D015997:Neonatal Screening / Q000379:methods*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012815:Signal Processing, Computer-Assisted