title: 5 years review of periocular basal cell carcinoma and proposed follow-up protocol.
abstract: OBJECTIVE
  (1) To investigate the recurrence of periocular basal cell carcinoma (BCC) reported as completely excised on histology. (2) To identify risks associated with recurrence. (3) To recommend a rational follow-up protocol.
  
  
  METHODS
  This is a cohort study by case note review of consecutive patients undergoing excision of periocular BCC between 2000 and 2006 at University Hospitals of Leicester. All lesions were excised with 3 mm clinical margin and the defect reconstructed only after the excision margin was declared clear.
  
  
  RESULTS
  A total of 413 episodes of surgical excision were recorded for 270 patients over the 7-year period of 2000-2006. All of them have 5 years follow-up. Mean age 73.7 (±12.5). In all, 67% were nodular BCC and 45.4% located in the lower eyelid. The main outcome measure was the recurrence rate. None of the patients with primary nodular BCC suffered recurrence. The recurrence rate for primary morphoeaform BCC following complete excision is 3.8%. In total, 8.1% of patients had several lesions simultaneously whereas 7.8% patients had BCC in multiple locations subsequently (metachronous). Three patients who had previously recurrent BCC (rBCC) treated elsewhere or not using this method had orbital/lacrimal drainage system involvement requiring exenteration.
  
  
  CONCLUSIONS
  We recommend that patients with a single, completely excised primary solid or nodular BCC can be discharged after one 6-monthly review, although they should be instructed to monitor for the development of further lesions. The incidence of recurrence for primary morphoeaform BCC is 3.8% and for rBCC is 3.6% over 5 years and these patients should stay under review for this period.
authors.affiliation: Department of Ophthalmology, Leicester Royal Infirmary, Leicester, UK. s_ho2@yahoo.com
authors.forename: S F
authors.initials: SF
authors.lastname: Ho
authors.forename: L
authors.initials: L
authors.lastname: Brown
authors.forename: M
authors.initials: M
authors.lastname: Bamford
authors.forename: R
authors.initials: R
authors.lastname: Sampath
authors.forename: J
authors.initials: J
authors.lastname: Burns
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000453:epidemiology* / Q000601:surgery; D015331:Cohort Studies; D005142:Eyelid Neoplasms / Q000453:epidemiology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000601:surgery; D011795:Surveys and Questionnaires; D006113:United Kingdom / Q000453:epidemiology