title: Effect of PGX, a novel functional fibre supplement, on subjective ratings of appetite in overweight and obese women consuming a 3-day structured, low-calorie diet.
abstract: BACKGROUND
  Dietary factors that help control perceived hunger might improve adherence to calorie-reduced diets.
  
  
  OBJECTIVE
  The objective of the study was to investigate the effect of supplementing a three-day, low-calorie diet with PolyGlycopleX (PGX), a highly viscous fibre, on subjective ratings of appetite compared with a placebo.
  
  
  METHODS
  In a double-blind crossover design with a 3-week washout, 45 women (aged 38±9 years, body mass index 29.9±2.8 kg m(-2)) were randomised to consume a 1000-kcal per day diet for 3 days, supplemented with 5 g of PGX or placebo at each of breakfast, lunch and dinner. Subjective appetite was assessed using 100 mm visual analogue scales that were completed daily before, between and after consumption of meals.
  
  
  RESULTS
  Thirty-five women completed the study. Consumption of PGX compared with placebo led to significantly lower mean area under the curve for hunger on day 3 (440.4 versus 375.4; P=0.048), prospective consumption on day 3 (471.0 versus 401.8; P=0.017) and the overall 3-day average (468.6 versus 420.2; P=0.026). More specifically, on day 3 PGX significantly reduced total appetite, hunger, desire to eat and prospective consumption for 2.5 and 4.5 h after lunch and before dinner times, with hunger also being reduced 2.5 h after dinner (P<0.05).
  
  
  CONCLUSIONS
  The results show that adding 5 g of PGX to meals during consumption of a low-calorie diet reduces subjective ratings of prospective consumption and increases the feelings of satiety, especially during afternoon and evening. This highly viscous polysaccharide may be a useful adjunct to weight-loss interventions involving significant caloric reductions.
authors.affiliation: Canadian Centre for Functional Medicine, Coquitlam, British Columbia, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Kacinik
authors.forename: M
authors.initials: M
authors.lastname: Lyon
authors.forename: M
authors.initials: M
authors.lastname: Purnama
authors.forename: R A
authors.initials: RA
authors.lastname: Reimer
authors.forename: R
authors.initials: R
authors.lastname: Gahler
authors.forename: T J
authors.initials: TJ
authors.lastname: Green
authors.forename: S
authors.initials: S
authors.lastname: Wood