title: Anti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeata.
abstract: An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2-6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC₅₀) of 2.50 μg/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC₅₀ of 7.11 μg/mL, and anti-HRV3 activity, with an IC₅₀ of 4.69 μg/mL, without demonstrable cytotoxicity at a concentration of 20 μg/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus.
authors.affiliation: Marine Chemomics Lab., Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Korea.
authors.forename: Soon-Hye
authors.initials: SH
authors.lastname: Park
authors.affiliation: Zoonosis Research Center, Wonkwang University College of Medicine & Oriental Medicine, 344-2, Iksan, Chonbuk 570-749, Korea.
authors.forename: Jae-Hyoung
authors.initials: JH
authors.lastname: Song
authors.affiliation: Marine Chemomics Lab., Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Korea.
authors.forename: Taejung
authors.initials: T
authors.lastname: Kim
authors.affiliation: Department of Microbiology and Basic Science, Kwandong University College of Medicine, Gangneung 210-701, Korea.
authors.forename: Woon-Seob
authors.initials: WS
authors.lastname: Shin
authors.affiliation: Department of Microbiology and Basic Science, Kwandong University College of Medicine, Gangneung 210-701, Korea.
authors.forename: Gab Man
authors.initials: GM
authors.lastname: Park
authors.affiliation: Department of Microbiology and Basic Science, Kwandong University College of Medicine, Gangneung 210-701, Korea.
authors.forename: Seokjoon
authors.initials: S
authors.lastname: Lee
authors.affiliation: Marine Chemomics Lab., Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Korea.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Marine Chemomics Lab., Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Korea.
authors.forename: Pilju
authors.initials: P
authors.lastname: Choi
authors.affiliation: Marine Chemomics Lab., Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Korea.
authors.forename: Heejin
authors.initials: H
authors.lastname: Kim
authors.affiliation: Immune Modulator Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea.
authors.forename: Hui-Seong
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Immune Modulator Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea.
authors.forename: Dur-Han
authors.initials: DH
authors.lastname: Kwon
authors.affiliation: Zoonosis Research Center, Wonkwang University College of Medicine & Oriental Medicine, 344-2, Iksan, Chonbuk 570-749, Korea.
authors.forename: Hwa Jung
authors.initials: HJ
authors.lastname: Choi
authors.affiliation: Marine Chemomics Lab., Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Korea.
authors.forename: Jungyeob
authors.initials: J
authors.lastname: Ham
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002396:Catechols / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D012229:Rhinovirus / Q000187:drug effects*; D000461:Rhodophyta / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D000998:Antiviral Agents; D002396:Catechols