title: Development of a multifunctional detoxifying unit for liver failure patients.
abstract: OBJECTIVE
  Extracorporeal blood detoxification strategies aimed at supporting impaired liver function have been explored because of the imbalance between donor organs and waiting patients. A limited number of artificial devices are now available clinically, and these are characterized by the use of multistage adsorption procedures in conjunction with hemodialysis, but these features simultaneously increase system complexity and treatment costs.
  
  
  METHODS
  The authors developed a simpler strategy for liver dialysis based on the use of a multifunctional filter, which enables plasma separation and perfusion in a single unit.
  
  
  RESULTS
  Liver dialysis treatments were successfully performed using the devised unit when bovine blood containing uremic and hepatic toxins was circulated. Removal of the solutes under investigation was significant, and reduction ratios of 78% for urea, 98% for creatinine and 91% for bilirubin were achieved. Plasma free hemoglobin levels were reasonably maintained despite prolonged blood recirculation for 5 h, and platelet, hematocrit and hemoglobin levels remained uniform throughout liver dialysis sessions.
  
  
  CONCLUSIONS
  The devised liver support unit may offer a straightforward and efficient means of cleansing blood for patients with hepatic failure.
authors.affiliation: AnC Bio Inc., Seoul, Korea. jake0902@snu.ac.kr
authors.forename: Kyungsoo
authors.initials: K
authors.lastname: Lee
authors.forename: Cho Hae
authors.initials: CH
authors.lastname: Mun
authors.forename: Byoung Goo
authors.initials: BG
authors.lastname: Min
mesh_terms: D017583:Hemodiafiltration / Q000295:instrumentation / Q000379:methods; D006757:Hospital Units; D006801:Humans; D017093:Liver Failure / Q000097:blood* / Q000628:therapy*; D019164:Liver, Artificial; D016060:Sorption Detoxification / Q000295:instrumentation / Q000379:methods