title: How two sites of inflammation promote carcinogenesis: The role of macrophages in inflammation associated carcinogenesis.
abstract: We recently reported that anti-inflammatory macrophages contribute to the initiation of colorectal carcinogenesis in IBD patients by inducing epithelial-mesenchymal-transition associated alterations in colonic epithelial cells. In this process, TGFβ1 dependent upregulation of the adhesion molecule L1CAM is one key event, paving the way to colitis associated tumorigenesis and metastatic spread.
authors.affiliation: Department of Inflammatory Carcinogenesis; Institute for Experimental Medicine; Kiel, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Sebens
authors.forename: Heiner
authors.initials: H
authors.lastname: Schäfer