title: [Screening for glaucoma by blue light-pattern ERG and OCT--are the methods comparable?].
abstract: BACKGROUND
  Up to now, several examinations are necessary to identify early glaucoma. It is also possible to analyse the peripapillary retinal nerve fibre layer thickness by means of OCT. The loss of retinal ganglion cells can be measured by pattern ERG, therefore this method could be used for the detection of early glaucoma. This study compares the results of the blue light-pattern ERG with the Stratus OCT for glaucoma early recognition.
  
  
  METHODS
  We studied 30 healthy test persons, 20 patients with glaucoma and 20 patients with suspected glaucoma. Each group was examined using eye pressure measurements, funduscopy, perimetry, pachymetry und analysing the retinal nerve fibre layer by the Stratus OCT. The diagnostic work-up was completed by the pattern ERG and an upgrade with a blue light filtering glass. The results of the blue light-pattern ERG and the OCT ("healthy" or "pathological") were compared in a cross table and the agreement between these two raters was measured by the Cohen's kappa coefficient.
  
  
  RESULTS
  Pattern ERG and blue light-pattern ERG decrease with advancing age. After developing an age-matched calibration graph we defined standard values up to the age of 56 years. All included subjects were classified by Stratus OCT and blue light-pattern ERG as healthy. We recognised a significant reduction of the retinal nerve fibre layer thickness and the amplitude in the pattern ERG in the cluster of glaucoma patients. For most of them, a blue light-pattern ERG could not be recorded. Nine out of 40 glaucoma suspect eyes were judged as "pathological". Regarding the amplitudes of the blue light-pattern ERG 25 of 28 eyes under suspicion of glaucoma were assigned as "healthy". With the aid of the cross table we estimated a Cohen's kappa of 0.4. The sensitivity of the blue light-pattern ERG was computed to be 70 % and the specificity to be 97.7 %. For the OCT we calculated the sensitivity to be 50 % and the specificity to be 100 %.
  
  
  CONCLUSIONS
  The blue light-pattern ERG correlates in 87 % of our cases with the OCT. Healthy test persons are certainly identified just as well as definitely glaucomatous patients. To distinguish people suspected of early glaucoma the blue light-pattern ERG can be used as an additional, fast and economic diagnostic procedure.
authors.affiliation: Augenklinik, Universitätsklinikum Rostock, Germany. katrin.wolff@med.uni-rostock.de
authors.forename: K
authors.initials: K
authors.lastname: Wolff
authors.forename: F
authors.initials: F
authors.lastname: Treumer
authors.forename: A
authors.initials: A
authors.lastname: Jochens
authors.forename: J B
authors.initials: JB
authors.lastname: Roider
authors.forename: C
authors.initials: C
authors.lastname: Kandzia
mesh_terms: D000328:Adult; D000368:Aged; D003116:Color; D003124:Colorimetry / Q000379:methods*; D004596:Electroretinography / Q000379:methods*; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D008029:Lighting / Q000379:methods*; D008297:Male; D008403:Mass Screening / Q000379:methods*; D010775:Photic Stimulation / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*