title: Cord blood cellular proliferative response as a predictive factor for atopic dermatitis at 12 months.
abstract: Since the risk of developing allergic disease increases in individuals exposed to allergens previously, even during the neonatal period, the immunologic status of a fetus may be important in the subsequent development of allergy. We evaluated the fetal factors to predict atopic dermatitis (AD) at 12 months in 412 infants of a COhort for Childhood Origin of Asthma and Allergic Diseases (COCOA) in the general Korean population. Cord blood mononuclear cells (CBMCs) were stimulated with ovalbumin and phytohemagglutinin and cellular proliferative response and concentrations of interleukin-13 and interferon-γ, were measured. The risk of developing AD was greater in boys than girls (OR 1.97, 95% CI 1.26-3.09), infants delivered by cesarean section than vaginally (OR 1.93, 95% CI 1.14-3.26) and infants with than without parental history of AD (OR 2.34, 95% CI 1.29-4.24). The CBMC proliferative response to phytohemagglutinin stimulation was higher in infants with than without AD (P = 0.048), but no difference was observed in ovalbumin-stimulated cells (P = 0.771). Risk factors for the development of AD at 12 months include male gender, delivery by cesarean section and parental history of AD. Increased CBMC proliferative response to phytohemagglutinin stimulation may predict the development of AD at 12 months.
authors.affiliation: Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
authors.forename: Hyo-Bin
authors.initials: HB
authors.lastname: Kim
authors.forename: Kang Mo
authors.initials: KM
authors.lastname: Ahn
authors.forename: Kyung Won
authors.initials: KW
authors.lastname: Kim
authors.forename: Youn Ho
authors.initials: YH
authors.lastname: Shin
authors.forename: Jinho
authors.initials: J
authors.lastname: Yu
authors.forename: Ju-Hee
authors.initials: JH
authors.lastname: Seo
authors.forename: Hyung Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Ji-Won
authors.initials: JW
authors.lastname: Kwon
authors.forename: Byoung-Ju
authors.initials: BJ
authors.lastname: Kim
authors.forename: Ja-Young
authors.initials: JY
authors.lastname: Kwon
authors.forename: Suk-Joo
authors.initials: SJ
authors.lastname: Choi
authors.forename: Kyung-Ju
authors.initials: KJ
authors.lastname: Lee
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Park
authors.forename: Hye-Sung
authors.initials: HS
authors.lastname: Won
authors.forename: Soo-Jong
authors.initials: SJ
authors.lastname: Hong
mesh_terms: D000328:Adult; D049109:Cell Proliferation; D002585:Cesarean Section; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000378:metabolism; D018793:Interleukin-13 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D016017:Odds Ratio; D010047:Ovalbumin / Q000633:toxicity; D010835:Phytohemagglutinins / Q000633:toxicity; D011237:Predictive Value of Tests; D011247:Pregnancy; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D018793:Interleukin-13; D010835:Phytohemagglutinins; D007371:Interferon-gamma; D010047:Ovalbumin