title: Zinc oxide nanoflowers make new blood vessels.
abstract: It is well established that angiogenesis is the process of formation of new capillaries from pre-existing blood vessels. It is a complex process, involving both pro- and anti-angiogenic factors, and plays a significant role in physiological and pathophysiological processes such as embryonic development, atherosclerosis, post-ischemic vascularization of the myocardium, tumor growth and metastasis, rheumatoid arthritis etc. This is the first report of zinc oxide (ZnO) nanoflowers that show significant pro-angiogenic properties (formation of new capillaries from pre-existing blood vessels), observed by in vitro and in vivo angiogenesis assays. The egg yolk angiogenesis assay using ZnO nanoflowers indicates the presence of matured blood vessels formation. Additionally, it helps to promote endothelial cell (EA.hy926 cells) migration in wound healing assays. Formation of reactive oxygen species (ROS), especially hydrogen peroxide (H(2)O(2))-a redox signaling molecule, might be the plausible mechanism for nanoflower-based angiogenesis. Angiogenesis by nanoflowers may provide the basis for the future development of new alternative therapeutic treatment strategies for cardiovascular and ischemic diseases, where angiogenesis plays a significant role.
authors.affiliation: Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad-500607, AP, India.
authors.forename: Ayan Kumar
authors.initials: AK
authors.lastname: Barui
authors.forename: Vimal
authors.initials: V
authors.lastname: Veeriah
authors.forename: Sudip
authors.initials: S
authors.lastname: Mukherjee
authors.forename: Joydeb
authors.initials: J
authors.lastname: Manna
authors.forename: Ajay Kumar
authors.initials: AK
authors.lastname: Patel
authors.forename: Sujata
authors.initials: S
authors.lastname: Patra
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Pal
authors.forename: Shruthi
authors.initials: S
authors.lastname: Murali
authors.forename: Rohit K
authors.initials: RK
authors.lastname: Rana
authors.forename: Suvro
authors.initials: S
authors.lastname: Chatterjee
authors.forename: Chitta Ranjan
authors.initials: CR
authors.lastname: Patra
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004530:Egg Yolk / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D050997:Nanomedicine; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D018919:Neovascularization, Physiologic / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D017382:Reactive Oxygen Species; D042461:Vascular Endothelial Growth Factor A; D015034:Zinc Oxide