title: Production of epitope-specific antibodies using peptide-CpG-ODN-liposome complex without carriers and their application as a cancer vaccine in mice.
abstract: Low efficacy of peptide vaccines limits their potential application. We developed a powerful strategy to produce epitope-specific antibodies using peptides. Immunization with novel formula into mice showed target-specific prophylactic and therapeutic effects against tumors. Our strategy will be useful for rapid eiptope screening, therapeutic antibody production and cancer vaccine development.
authors.affiliation: Department of Biochemistry; College of Natural Sciences; Chungbuk National University, Chungbuk; Republic of Korea.
authors.forename: Younghee
authors.initials: Y
authors.lastname: Lee
authors.forename: Hyung-Joo
authors.initials: HJ
authors.lastname: Kwon