title: Human radiation dose estimation of (11)C-CFT using whole-body PET.
abstract: OBJECTIVE
  C-Labeled 2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane (C-CFT) is a commonly used positron emission tomography (PET) tracer for dopamine transporters imaging. The present study estimated human radiation absorbed doses of C-CFT based on whole-body PET imaging in healthy subjects.
  
  
  METHODS
  Whole-body PET was performed on 6 subjects after injection of 472.06 ± 116.47 MBq of C-CFT. 7 Frames were acquired for about 70 min in 7 segments of the body. Regions of interest were drawn on PET images of source organs. Residence time was calculated as the area under the time-activity curve. Radiation dosimetry was calculated from organ residence time using the medical internal radiation dosimetry (MIDR) method.
  
  
  RESULTS
  The organs with the highest radiation-absorbed doses were the urinary bladder, followed the spleen, pancreas, kidneys, and stomach. The dose-limiting critical organ was the urinary bladder. The effective dose was 8.89E-03 mSv/MBq (22.9 mrem/mCi). Biexponential fitting of mean bladder activity demonstrated that 18% of activity was excreted via the urine.
  
  
  CONCLUSIONS
  The potential radiation risks of C-CFT associated with in this study are well within accepted limits. C-CFT demonstrates a favorable radiation dose profile in humans and allows multiple PET examinations on the same subject per year.
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Huang
authors.forename: Hongliang
authors.initials: H
authors.lastname: Wang
authors.forename: Ganghua
authors.initials: G
authors.lastname: Tang
authors.forename: Xiang
authors.initials: X
authors.lastname: Liang
authors.forename: Huaifu
authors.initials: H
authors.lastname: Deng
authors.forename: Chang
authors.initials: C
authors.lastname: Yi
authors.forename: Xiangsong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D003042:Cocaine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011829:Radiation Dosage; D011874:Radiometry; D051598:Whole Body Imaging
chemical_list: C021279:(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester; D003042:Cocaine