title: Management of blood glucose in patients with acute coronary syndromes.
abstract: Hyperglycemia during admission for acute myocardial infarction (MI) is common and associated with poor outcomes. Prior studies employed two distinct approaches to improve outcomes in patients with acute MI--one focused on glucose control, and the other on provision of glucose, insulin, and potassium. However, despite multiple largescale studies, the benefits of glucose lowering in the setting of acute MI remain unclear. This article reviews data from observational studies and clinical trials and synthesizes this information into practical recommendations based on available evidence.
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Kasia J
authors.initials: KJ
authors.lastname: Lipska
authors.forename: Mikhail
authors.initials: M
authors.lastname: Kosiborod
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D002314:Cardioplegic Solutions / Q000009:adverse effects / Q000627:therapeutic use*; D005947:Glucose / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D007328:Insulin / Q000009:adverse effects / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D010343:Patient Admission; D018579:Patient Selection; D011188:Potassium / Q000009:adverse effects / Q000627:therapeutic use; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D002314:Cardioplegic Solutions; D007004:Hypoglycemic Agents; D007328:Insulin; C030396:glucose-insulin-potassium cardioplegic solution; D005947:Glucose; D011188:Potassium