title: Does adiponectin level explain the atherogenic properties of Hp 2-2 phenotype in type 2 diabetic patients?
abstract: OBJECTIVE
  Haptoglobin (Hb) and adiponectin are antioxidant proteins and independent predictors of atherosclerotic vascular disease in diabetic patients. The link between Hp phenotype and circulating adiponectin levels were examined.
  
  
  METHODS
  Diabetic patients were divided into two groups by Hp phenotype: Hp 2-2 group and non-Hp 2-2 group (Hp 2-1 and Hp 1-1). Blood glucose, HbA1C, insulin, lipids, CRP, HOMA-IR, 25OH vitamin D, leptin and adiponectin levels were measured. Pulse wave velocity (PWV) was performed using SphygmoCor (version 7.1, AtCor Medical, Sydney, Australia).
  
  
  RESULTS
  PWV was significantly higher in patients homozygous for the 2 allele (Hp 2-2) compared to non-Hp 2-2 patients (Hp 1-1 and Hp 1-2), p < 0.0001. Adiponectin was significantly lower in Hp 2-2 patients than in non-Hp 2-2 group (p < 0.016). Neither leptin nor the leptin adiponectin ratio (LAR) differed significantly between groups.
  
  
  CONCLUSIONS
  PWV was significantly higher and plasma adiponectin levels were significantly lower in diabetic patients homozygous for the 2 allele (Hp 2-2). These differences were detected despite the lack of by-phenotype differences in glycemic control, blood pressure level or presence of cardiovascular risk factor and suggest an active role of adiponectin in the pathophysiology of vascular disease in this population.
authors.affiliation: Department of Plastic Surgery, Wolfson Medical Center, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Frand
authors.forename: A
authors.initials: A
authors.lastname: Borislavsky
authors.forename: M
authors.initials: M
authors.lastname: Boaz
authors.forename: Z
authors.initials: Z
authors.lastname: Matas
authors.forename: M
authors.initials: M
authors.lastname: Shargorodsky
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D050197:Atherosclerosis / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype
chemical_list: D052242:Adiponectin; C485359:HP protein, human; D006242:Haptoglobins