title: Early life exposure to air pollution: how bad is it?
abstract: Increasing concentrations of air pollution have been shown to contribute to an enormity of adverse health outcomes worldwide, which have been observed in clinical, epidemiological, and animal studies as well as in vitro investigations. Recently, studies have shown that air pollution can affect the developing fetus via maternal exposure, resulting in preterm birth, low birth weight, growth restriction, and potentially adverse cardiovascular and respiratory outcomes. This review will provide a summary of the harmful effects of air pollution exposure on the developing fetus and infant, and suggest potential mechanisms to limit the exposure of pregnant mothers and infants to air pollution.
authors.affiliation: Department of Pediatrics, The Ohio State University, Columbus, OH 43215, USA.
authors.forename: Carl H
authors.initials: CH
authors.lastname: Backes
authors.forename: Timothy
authors.initials: T
authors.lastname: Nelin
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Gorr
authors.forename: Loren E
authors.initials: LE
authors.lastname: Wold
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D018811:Maternal Exposure / Q000009:adverse effects; D052638:Particulate Matter / Q000009:adverse effects; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D047928:Premature Birth / Q000139:chemically induced; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced; D050497:Stillbirth
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter