title: Enamine catalysis in flow with an immobilized peptidic catalyst.
abstract: Pep talk: An immobilized peptidic catalyst achieves more than 600 turnovers in a continuous-flow system, allowing the production of chiral γ-nitroaldehydes with excellent stereoselectivities on a scale of >450 mmol (>100 g). Such a high efficiency opens the way for more practical applications of enamine catalysis.
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Arakawa
authors.forename: Helma
authors.initials: H
authors.lastname: Wennemers
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D055767:Immobilized Proteins / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000447:Aldehydes; D000588:Amines; D055767:Immobilized Proteins; D010455:Peptides