title: Laminins and retinal vascular development.
abstract: The mechanisms controlling vascular development, both normal and pathological, are not yet fully understood. Many diseases, including cancer and diabetic retinopathy, involve abnormal blood vessel formation. Therefore, increasing knowledge of these mechanisms may help develop novel therapeutic targets. The identification of novel proteins or cells involved in this process would be particularly useful. The retina is an ideal model for studying vascular development because it is easy to access, particularly in rodents where this process occurs post-natally. Recent studies have suggested potential roles for laminin chains in vascular development of the retina. This review will provide an overview of these studies, demonstrating the importance of further research into the involvement of laminins in retinal blood vessel formation.
authors.affiliation: The Wilmer Eye Institute, Baltimore, MD, USA. medwar28@jhmi.edu
authors.forename: Malia M
authors.initials: MM
authors.lastname: Edwards
authors.forename: Olivier
authors.initials: O
authors.lastname: Lefebvre
mesh_terms: D000375:Aging; D000818:Animals; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D001485:Basement Membrane / Q000378:metabolism; D002465:Cell Movement; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007797:Laminin / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009154:Mutation; D011485:Protein Binding; D051381:Rats; D012160:Retina / Q000378:metabolism / Q000473:pathology; D012171:Retinal Vessels / Q000254:growth & development* / Q000378:metabolism
chemical_list: D007797:Laminin; C084098:laminin A