title: Higher protein intake strategies in human milk fortification for preterms infants feeding. Auxological and neurodevelopmental outcome.
abstract: Postnatal growth restriction and failure to thrive still remain a major problem in Extremely Low Birth Weight (ELBW) infants . The goal for the nutritional care of these infants is to achieve rate of growth similar to those of the fetus in utero at the equivalent gestational age. Human milk fortified remains the best food for all these preterms. Two groups of preterm of weight 580-1250 g and gestational age 23-32 wk, were fed with different protein intake in the human/maternal milk fortified ( 3,5 g Kg-1 per day and 4,8 g Kg-1 per day in the control and intervention group respectively).The feeding tolerance, intrahospital growth, neurological outcome and anthropometric data until 12 months of corrected age, were evaluated. The protein supplemented group (PSG) showed an intrahospital highter growth rate ( mostly in head circumference, p 0,02, and length growth, p 0,04) only in the preterms with 580-980 g and 23-30 wk. In the same preterms, Griffith Development Mental Score at 3 and 12 months corrected age showed higher score than in the control group in the Performance (p 0,04) and Hearing/Language (p 0,03) items. The auxological evaluation in the postdischarge period showed in the PSG group mean z-score values for length higher than those in the control group at 9 (p 0,04) months of corrected age.
authors.affiliation: Pediatric and Neonatal Intensive Care Unit, Bufalini Hospital Cesena, Cesena, Italy. abiasini@ausl-cesena.emr.it
authors.forename: A
authors.initials: A
authors.lastname: Biasini
authors.forename: C
authors.initials: C
authors.lastname: Neri
authors.forename: M C
authors.initials: MC
authors.lastname: China
authors.forename: F
authors.initials: F
authors.lastname: Monti
authors.forename: P
authors.initials: P
authors.lastname: Di Nicola
authors.forename: E
authors.initials: E
authors.lastname: Bertino
mesh_terms: D001724:Birth Weight / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D001942:Breast Feeding; D016022:Case-Control Studies; D004750:Enteral Nutrition; D005183:Failure to Thrive / Q000178:diet therapy*; D005260:Female; D005527:Food, Fortified; D005865:Gestational Age; D006309:Hearing / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007225:Infant Food; D052577:Infant, Extremely Low Birth Weight / Q000254:growth & development* / Q000523:psychology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development* / Q000523:psychology; D007774:Lactation; D007802:Language; D008895:Milk, Human / Q000737:chemistry* / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009483:Neuropsychological Tests; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D011506:Proteins