title: Chromatin organization, epigenetics and differentiation: an evolutionary perspective.
abstract: Genome packaging is a universal phenomenon from prokaryotes to higher mammals. Genomic constituents and forces have however, travelled a long evolutionary route. Both DNA and protein elements constitute the genome and also aid in its dynamicity. With the evolution of organisms, these have experienced several structural and functional changes. These evolutionary changes were made to meet the challenging scenario of evolving organisms. This review discusses in detail the evolutionary perspective and functionality gain in the phenomena of genome organization and epigenetics.
authors.affiliation: Transcription and Disease Laboratory, Molecular Biology and Genetics Unit (MBGU), Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur Post, Bangalore, 560064, India.
authors.forename: Sujata
authors.initials: S
authors.lastname: Kumari
authors.forename: Amrutha
authors.initials: A
authors.lastname: Swaminathan
authors.forename: Snehajyoti
authors.initials: S
authors.lastname: Chatterjee
authors.forename: Parijat
authors.initials: P
authors.lastname: Senapati
authors.forename: Ramachandran
authors.initials: R
authors.lastname: Boopathi
authors.forename: Tapas K
authors.initials: TK
authors.lastname: Kundu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D002843:Chromatin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication; D044127:Epigenesis, Genetic; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D016678:Genome; D006657:Histones / Q000378:metabolism; D006801:Humans; D009690:Nucleic Acid Conformation
chemical_list: D002843:Chromatin; D006657:Histones; D004247:DNA