title: [Study on the correlation between chronic asymptomatic HBV carriers of yin asthenia constitution and genotypes of HLA-DRB1 and HLA DQA1 alleles].
abstract: OBJECTIVE
  To study on the correlation between chronic asymptomatic HBV carriers (ASC) of yin asthenia constitution and genotypes of HLA-DRB1 and HLA DQA1 alleles.
  
  
  METHODS
  Totally 105 ASC were assigned to two groups according to their constitutions, i.e., the yin asthenia group (47 cases) and the non-yin asthenia group (58 cases). The genotypes of HLA-DRB1 and HLA DQA1 alleles were determined using PCR-SSP.
  
  
  RESULTS
  The gene frequency of HLA-DRB1 * 09 allele and HLA-DQA1 * 0301 allele (being 12.1% and 19.1%) were obviously lower in the yin asthenia group than in the non-yin asthenia group (being 27.8% and 39.7%, P < 0.05). The gene frequency of HLA-DRB1 * 11 allele and HLA-DQA1 * 0501 allele were obviously higher in the yin asthenia group (being 12.1% and 28.7%) than in the non-yin asthenia group (4.3% and 9.5%), showing statistical difference (P < 0.05, P < 0.01).
  
  
  CONCLUSIONS
  HLA-DRB1 * 09 allele and HLA-DQA1 * 0301 allele might be the molecular bases for non-yin asthenia patients with ASC. HLA-DRB1 * 11 allele and HLA-DQA1 * 0501 allele might be the molecular bases for yin asthenia patients with ASC.
authors.affiliation: Department of Integrative Medicine, Sixth People's Hospital of Hangzhou, Hangzhou. guojianchun1961@126.com
authors.forename: Jian-chun
authors.initials: JC
authors.lastname: Guo
authors.forename: Li-na
authors.initials: LN
authors.lastname: Xiao
authors.forename: Yun-hao
authors.initials: YH
authors.lastname: Xun
mesh_terms: D000293:Adolescent; D000328:Adult; D002353:Carrier State; D003249:Constitution and Bylaws; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D059848:HLA-DQ alpha-Chains / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D059811:HLA-DRB1 Chains