title: Endometrial cancer: utility of diffusion-weighted magnetic resonance imaging with background body signal suppression at 3T.
abstract: OBJECTIVE
  To prospectively assess the usefulness of diffusion-weighted magnetic resonance imaging (MRI) with background body signal suppression (DWIBS) at 3T for the preoperative evaluation of endometrial cancer.
  
  
  METHODS
  Fifty-two consecutive patients with biopsy-proven endometrial cancer were examined with a 3T MR scanner, followed by a hysterectomy. MR examinations included T2-weighted (T2WI), DWIBS, and dynamic contrast-enhanced T1-weighted imaging (DCEI). The apparent diffusion coefficient (ADC) was calculated in the tumor and normal myometrium. According to tumor grade, the mean ADC of the tumor was analyzed. The depth of myometrial invasion was independently assessed by two radiologists for three MRI datasets on a five-point scale.
  
  
  RESULTS
  The mean ADC of the tumors was significantly lower than that of normal myometrium (P < 0.001). The mean ADC of grades 2 or 3 was significantly lower than grade 1 (P < 0.01). For predicting myometrial invasion, the specificity, accuracy, and area under the curve of combined T2WI and DWIBS in both readers were similar to DCEI (P > 0.05). Interreader agreement in all MRI datasets was excellent.
  
  
  CONCLUSIONS
  DWIBS at 3T has potential for being an effective method for the preoperative evaluation of endometrial cancer.
authors.affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Seo
authors.forename: Chan Kyo
authors.initials: CK
authors.lastname: Kim
authors.forename: Dongil
authors.initials: D
authors.lastname: Choi
authors.forename: Byung
authors.initials: B
authors.lastname: Kwan Park
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D016477:Artifacts; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011300:Preoperative Care / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique