title: Glutathione-S-transferase T1 polymorphism is associated with esophageal cancer risk in Chinese Han population.
abstract: BACKGROUND
  Glutathione-S-Transferase T1 (GSTT1) gene has been shown to be involved in the development of esophageal cancer. However, the results have been inconsistent. In this study, the authors performed a meta- analysis to clarify the association between GSTT1 polymorphism and esophageal cancer risk among Chinese Han population.
  
  
  METHODS
  Published literature from PubMed, the China National Knowledge Infrastructure and Wanfang Data were searched. Pooled odds ratio (OR) and 95% confidence interval (95%CI) was calculated using a fixed- or random-effects model.
  
  
  RESULTS
  Eleven studies with a total of 2779 individuals were included in the meta-analysis. The results showed that GSTT1 null genotype was significantly associated with esophageal cancer risk in Chinese (OR = 1.31, 95%CI 1.12 to 1.53, p = 0.001). Further sensitivity analyses confirmed the significant association. The cumulative meta-analysis showed a trend of an obvious association between GSTT1 null genotype and esophageal cancer risk as information accumulated by year.
  
  
  CONCLUSIONS
  This meta-analysis suggests a significant association of GSTT1 null genotype with esophageal cancer risk in the Chinese Han population.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, No.4 people's hospital of Wuxi City, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Weng
authors.forename: Bojian
authors.initials: B
authors.lastname: Fei
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.forename: Ming
authors.initials: M
authors.lastname: Cai
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D016001:Confidence Intervals; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase