title: [Renal failure after gastrointestinal hemorrhage: case 10/2012].
abstract: METHODS
  We report on a 78-year-old female patient, who presented to the emergency department with nausea and vomiting.
  
  
  METHODS
  Endoscopy of the upper gastrointestinal tract revealed gastric erosions and duodenal ulcers. The patient had iron deficiency anemia.
  
  
  METHODS
  Following treatment with a proton pump inhibitor (PPI) the patient developed fever, signs of inflammation and oliguric renal failure. In the urine-dipstick there was minimal hematuria and leukocyturia. Urinary protein-differentiation revealed tubular proteinuria with excretion of α1-microglobulin. Renal biopsy showed interstitial nephritis with infiltration of eosinophilic granulocytes. After stopping treatment with PPI and commencing glucocorticoid therapy, the patient recovered fully from renal failure.
  
  
  CONCLUSIONS
  Allergic interstitial nephritis following PPI treatment is an important differential diagnosis of renal failure of unknown cause and has a good prognosis when promptly diagnosed and treated.
authors.affiliation: Medizinische Klinik, Universitätsklinikum Tübingen.
authors.forename: N
authors.initials: N
authors.lastname: Celebi
authors.forename: P
authors.initials: P
authors.lastname: Weyrich
authors.forename: H
authors.initials: H
authors.lastname: Bunz
authors.forename: J
authors.initials: J
authors.lastname: Velden
authors.forename: F
authors.initials: F
authors.lastname: Artunc
mesh_terms: D000368:Aged; D004342:Drug Hypersensitivity / Q000209:etiology*; D057915:Drug Substitution; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control
chemical_list: D005938:Glucocorticoids; D054328:Proton Pump Inhibitors