title: CE-MS for metabolomics: developments and applications in the period 2010-2012.
abstract: CE-MS has emerged as a powerful technique for the profiling of (highly) polar and charged metabolites in biological samples. This review provides an update of the most recent developments in CE-MS for metabolomics covering the scientific literature from July 2010 to June 2012. The present paper is an update of two previous review papers covering the years 2000-2010 (Electrophoresis 2009, 30, 276-291; Electrophoresis 2011, 32, 52-65). Emerging technological developments used in CE-MS for metabolomics are discussed, such as the use of novel interfacing techniques for coupling CE to MS. Representative examples illustrate the applicability of CE-MS in the fields of biomedical, clinical, microbial, plant, environmental and food metabolomics. Concerning targeted and non-targeted approaches, a comprehensive overview of recent CE-MS-based metabolomics studies is given in a table. Information on sample type and pretreatment, capillary coatings and MS detection mode is provided. Finally, general conclusions and perspectives are provided.
authors.affiliation: Biomolecular Analysis, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, TB Utrecht, The Netherlands. rawi.ramautar@gmail.com
authors.forename: Rawi
authors.initials: R
authors.lastname: Ramautar
authors.forename: Govert W
authors.initials: GW
authors.lastname: Somsen
authors.forename: Gerhardus J
authors.initials: GJ
authors.lastname: de Jong
mesh_terms: D000818:Animals; D019963:Clinical Chemistry Tests / Q000379:methods; D019075:Electrophoresis, Capillary / Q000379:methods* / Q000639:trends; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods* / Q000639:trends; D055432:Metabolomics / Q000639:trends*; D010944:Plants / Q000737:chemistry; D052616:Solid Phase Extraction / Q000379:methods; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods / Q000639:trends