title: BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia.
abstract: In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia.
authors.affiliation: Division of Hematology/Oncology, Northwestern University, University of Chicago, Chicago, IL 60637, USA. j-crispino@northwestern.edu
authors.forename: John D
authors.initials: JD
authors.lastname: Crispino
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Le Beau