title: Tyrosine-kinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: a systematic review.
abstract: The main objective of this systematic review is to quantify and to summarize all studies that have included health-related quality of life (HRQOL) or, any other type of patient-reported outcomes (PROs), in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs). Nine papers were found and none of these were published before 2003. Overall, 3290 CML patients were enrolled in the studies reviewed. Four studies reported HRQOL data on patients treated with imatinib only. The most solid data in this area indicate that CML patients receiving TKIs have a worse HRQOL profile when compared to their peers, without cancer, in the general population and interventions to improve HRQOL outcomes are thus needed. Our review revealed the paucity of evidence-based data in this area. However, HRQOL assessment in these studies emphasize the unique information provided by the patient's perspective. Urgent efforts are needed to provide solid PROs data to complement current knowledge on clinical efficacy of TKIs.
authors.affiliation: Italian Group for Adult Hematologic Diseases, GIMEMA, Data Center and Health Outcomes Research Unit, Rome, Italy. f.efficace@gimema.it
authors.forename: Fabio
authors.initials: F
authors.lastname: Efficace
authors.forename: Annarita
authors.initials: A
authors.lastname: Cardoni
authors.forename: Francesco
authors.initials: F
authors.lastname: Cottone
authors.forename: Marco
authors.initials: M
authors.lastname: Vignetti
authors.forename: Franco
authors.initials: F
authors.lastname: Mandelli
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D057566:Self Report; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011505:Protein-Tyrosine Kinases