title: Superparamagnetic iron oxide-enhanced interstitial magnetic resonance lymphography to detect a sentinel lymph node in tongue cancer patients.
abstract: CONCLUSIONS
  This is the first report on human sentinel node (SN) detection by interstitial magnetic resonance (MR) lymphography with superparamagnetic iron oxide (SPIO) in tongue cancer patients who also underwent lymphoscintigraphy. Our results indicate that further studies are warranted, as this novel method may replace current scintigraphic techniques.
  
  
  OBJECTIVE
  To examine the feasibility of interstitial MR lymphography using SPIO for SN detection in the head and neck region.
  
  
  METHODS
  MR images were acquired sequentially at 10 min, 30 min, and 24 h after submucosally injecting 0.1 ml SPIO (ferucarbotran) around the tumor in three patients with tongue cancer without cervical lymph node metastasis (clinical T2N0M0).
  
  
  RESULTS
  The SNs were clearly visualized in the 10 min interstitial MR lymphography images and were completely concordant with those visualized by (99m)Tc-radiocolloid lymphoscintigraphy and a gamma probe in all cases. Iron incorporation into the SNs was confirmed by pathological examination.
authors.affiliation: Department of Otolaryngology, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Mizokami
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kosuda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tomifuji
authors.forename: Koji
authors.initials: K
authors.lastname: Araki
authors.forename: Taku
authors.initials: T
authors.lastname: Yamashita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shinmoto
authors.forename: Akihiro
authors.initials: A
authors.lastname: Shiotani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D005260:Female; D005290:Ferric Compounds; D005927:Glossectomy / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D061305:Lymphoscintigraphy / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide