title: An efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase.
abstract: An efficient single-enzymatic cascade approach for the asymmetric synthesis of chiral amines has been developed, which applies the amino donor 3-aminocyclohexa-1,5-dienecarboxylic acid spontaneously tautomerizing to reach reaction completion with excellent ee values.
authors.affiliation: KTH Royal Institute of Technology, Division of Biochemistry, School of Biotechnology, AlbaNova University Center, SE-106 91 Stockholm, Sweden.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Henrik
authors.initials: H
authors.lastname: Land
authors.forename: Per
authors.initials: P
authors.lastname: Berglund
mesh_terms: D000586:Amination; D000588:Amines / Q000378:metabolism*; D055162:Biocatalysis; D002861:Chromobacterium / Q000201:enzymology; D003509:Cyclohexanecarboxylic Acids / Q000737:chemistry; D053138:Cyclohexenes / Q000737:chemistry; D013237:Stereoisomerism; D000637:Transaminases / Q000378:metabolism*
chemical_list: D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D053138:Cyclohexenes; C019441:isogabaculine; D000637:Transaminases