title: Complex small-molecule architectures regulate phenotypic plasticity in a nematode.
abstract: Chemistry the worm's way: The nematode Pristionchus pacificus constructs elaborate small molecules from modified building blocks of primary metabolism, including an unusual xylopyranose-based nucleoside (see scheme). These compounds act as signaling molecules to control adult phenotypic plasticity and dauer development and provide examples of modular generation of structural diversity in metazoans.
authors.affiliation: Boyce Thompson Institute and Department of Chemistry, Cornell University, Ithaca, NY, USA.
authors.forename: Neelanjan
authors.initials: N
authors.lastname: Bose
authors.forename: Akira
authors.initials: A
authors.lastname: Ogawa
authors.forename: Stephan H
authors.initials: SH
authors.lastname: von Reuss
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Yim
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Ragsdale
authors.forename: Ralf J
authors.initials: RJ
authors.lastname: Sommer
authors.forename: Frank C
authors.initials: FC
authors.lastname: Schroeder
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D055442:Metabolome; D009348:Nematoda / Q000378:metabolism*; D009705:Nucleosides / Q000737:chemistry / Q000378:metabolism; D010675:Pheromones / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D014994:Xylose / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism
chemical_list: D000596:Amino Acids; D005227:Fatty Acids; D009705:Nucleosides; D010675:Pheromones; D014157:Transcription Factors; C431715:xylopyranose; D014994:Xylose