title: Boron-containing peptidomimetics--a novel class of selective anti-tubercular drugs.
abstract: Medical treatment for tuberculosis is complicated nowadays by the appearance of new multiresistant strains, and therefore, new antibiotics are in great need. Here, we report the synthesis and in vitro testing of a new class of highly selective antimicrobial boron-containing peptidomimetics with compounds exhibiting activity against Mycobacterium tuberculosis at ≤5 μg/mL. The new approach developed makes it possible to synthesize variously substituted β-aminoboronic acids and their derivatives with a high level of diastereoselectivity.
authors.affiliation: Department of Chemistry, University of Tromsø, N-9037 Tromsø, Norway.
authors.forename: Alexey S
authors.initials: AS
authors.lastname: Gorovoy
authors.forename: Olga V
authors.initials: OV
authors.lastname: Gozhina
authors.forename: John S
authors.initials: JS
authors.lastname: Svendsen
authors.forename: Anna A
authors.initials: AA
authors.lastname: Domorad
authors.forename: George V
authors.initials: GV
authors.lastname: Tetz
authors.forename: Victor V
authors.initials: VV
authors.lastname: Tetz
authors.forename: Tore
authors.initials: T
authors.lastname: Lejon
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001895:Boron / Q000737:chemistry*; D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D057786:Peptidomimetics
chemical_list: D000995:Antitubercular Agents; D001897:Boronic Acids; D057786:Peptidomimetics; D001895:Boron