title: Silent brain infarcts: a cause of depression in the elderly?
abstract: The present study included 1047 elderly participants. At baseline, brain magnetic resonance imaging (MRI) was performed to detect infarcts and white matter lesions; further, depressive disorders were assessed. Participants were followed up during 3.6 years to determine incident and recurrent depression. We found an increased risk of recurrent depression associated with silent brain infarcts.
authors.affiliation: Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands.
authors.forename: Heidi C
authors.initials: HC
authors.lastname: Saavedra Perez
authors.forename: Nese
authors.initials: N
authors.lastname: Direk
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Meike W
authors.initials: MW
authors.lastname: Vernooij
authors.forename: Henning
authors.initials: H
authors.lastname: Tiemeier
authors.forename: Mohammad Arfan
authors.initials: MA
authors.lastname: Ikram
mesh_terms: D000368:Aged; D020520:Brain Infarction / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D003863:Depression / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D003866:Depressive Disorder / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D059906:Neuroimaging; D012307:Risk Factors