title: [Effect of intensive rosuvastatin therapy on adhesion molecules and the upstream mechanism in patients with peripheral atherosclerosis].
abstract: OBJECTIVE
  To investigate the effect of intensive rosuvastatin therapy on adhesion molecules in patients with peripheral atherosclerosis and explore the possible upstream mechanism.
  
  
  METHODS
  Twenty asymptomatic patients with peripheral atherosclerosis were enrolled and given 5-20 mg/day rosuvastatin for 3 months. Before and after the treatment, the lipid profile and plasma vascular cell adhesion molecule-1 (VCAM-1) levels were examined. The expression of intercellular adhesion molecule-1 (ICAM-1) in the mononuclear cells was measured using flow cytometry, and the mRNA and protein expressions of peroxisome proliferator-activated receptor γ (PPARγ) were detected using RT-PCR and Western blotting, respectively.
  
  
  RESULTS
  Compared with the baseline levels, ICAM-1 expression decreased and PPARγ protein expression increased in the lymphocytes. Rosuvastatin therapy did not produce obvious effects on plasma VCAM-1 level or ICAM-1 expression in the monocytes in these patients.
  
  
  CONCLUSIONS
  Rosuvastatin produces anti-inflammatory effects by decreasing the expression of ICAM-1 in mononuclear cells, and its upstream mechanism may involve the PPARγ pathway.
authors.affiliation: Second Department of Geriatric Cardiology, General Hospital of PLA, Beijing, China. drx1972@hotmail.com
authors.forename: Ruixue
authors.initials: R
authors.lastname: Du
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.forename: Guangtao
authors.initials: G
authors.lastname: Yan
authors.forename: Zihui
authors.initials: Z
authors.lastname: Deng
authors.forename: Wentao
authors.initials: W
authors.lastname: Liang
authors.forename: Honghong
authors.initials: H
authors.lastname: Zhang
authors.forename: Miao
authors.initials: M
authors.lastname: Geng
authors.forename: Zikuan
authors.initials: Z
authors.lastname: Guo
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wu
mesh_terms: D050197:Atherosclerosis / Q000188:drug therapy* / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D005464:Fluorobenzenes / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000008:administration & dosage / Q000627:therapeutic use*; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D005464:Fluorobenzenes; D047495:PPAR gamma; D011743:Pyrimidines; D013449:Sulfonamides; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D000068718:Rosuvastatin Calcium