title: [Physiological effects induced by dermorphin synthetic analogue--opilong].
abstract: The effects of repeated opilong injections in a dose of 50 microg/kg/day on subsequent learning of Wistar rats have been studied. The substance caused significant anxiolytic and analgesic effects, as the majority of animals could be learned (90% against 40% in control group) despite of painful stimulus preceding to education. Opilong in a small dose displaced a relation of excitatory-inhibit processes to significant prevalence of excitation although the substance was already absent in an organism for a long time. Raised peripheral sensitivity in all rats, provoked by opilong, correlated with CNS hyper excitability, expressed in stressful, neurotic psychoemotional reactions and in the form of active avoidance. The biochemical blood analysis in opilong-induced rats demonstrated the attributes of prethrombosis in the form of fibrinolysis depression and hypercoagulation. A view is expressed, that the neuromediator brain systems can be the basic point of opilong action, that are responsible for the excitatory-inhibit conditions of CNS functioning referred on maintenance of conditioned field stability.
authors.forename: K A
authors.initials: KA
authors.lastname: Nikol'skaia
authors.forename: L V
authors.initials: LV
authors.lastname: Eremina
authors.forename: L V
authors.initials: LV
authors.lastname: Podorol'skaia
authors.forename: T N
authors.initials: TN
authors.lastname: Serebriakova
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000378:metabolism / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005342:Fibrinolysis / Q000187:drug effects*; D007858:Learning / Q000187:drug effects*; D008297:Male; D018847:Opioid Peptides / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D019851:Thrombophilia / Q000151:congenital* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D000701:Analgesics, Opioid; D018847:Opioid Peptides; C030058:dermorphin