title: Biocompatible multishell architecture for iron oxide nanoparticles.
abstract: The coating of super-paramagnetic iron oxide nanoparticles (SPIONs) with multiple shells is demonstrated by building a layer assembled from carboxymethyldextran and poly(diallydimethylammonium chloride). Three shells are produced stepwise around aggregates of SPIONs by the formation of a polyelectrolyte complex. A growing particle size from 96 to 327 nm and a zeta potential in the range of +39 to -51 mV are measured. Microscopic techniques such as TEM, SEM, and AFM exemplify the core-shell structures. Magnetic force microscopy and vibrating sample magnetometer measurements confirm the architecture of the multishell particles. Cell culture experiments show that even nanoparticles with three shells are still taken up by cells.
authors.affiliation: Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry (IOMC), Friedrich Schiller University of Jena, Humboldtstraße 10, 07743 Jena, Germany.
authors.forename: Jana
authors.initials: J
authors.lastname: Wotschadlo
authors.forename: Tim
authors.initials: T
authors.lastname: Liebert
authors.forename: Joachim H
authors.initials: JH
authors.lastname: Clement
authors.forename: Nils
authors.initials: N
authors.lastname: Anspach
authors.forename: Stephanie
authors.initials: S
authors.lastname: Höppener
authors.forename: Tobias
authors.initials: T
authors.lastname: Rudolph
authors.forename: Robert
authors.initials: R
authors.lastname: Müller
authors.forename: Felix H
authors.initials: FH
authors.lastname: Schacher
authors.forename: Ulrich S
authors.initials: US
authors.lastname: Schubert
authors.forename: Thomas
authors.initials: T
authors.lastname: Heinze
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D001692:Biological Transport; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D018625:Microscopy, Atomic Force
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide