title: Relation among ghrelin, nutritional status, and immunity in children.
abstract: BACKGROUND
  Ghrelin is an important mediator of energy balance and metabolism. The aim of this study was to investigate the relationship among ghrelin concentration, growth patterns, and immunological parameters in children with an impairment or inefficiency in functioning of the immune system.
  
  
  METHODS
  Twenty patients with primary immunodeficiency diseases (PIDs), 20 patients with recurrent respiratory tract infections (RRTIs), and 20 healthy children (control group) were included. The anthropometric measurements, ghrelin plasma levels, and selected immunological parameters were measured.
  
  
  RESULTS
  Ghrelin levels and nutritional status parameters (weight, height, and body mass index) values were negatively correlated only in the control group. Ghrelin negatively correlates with complement hemolytic activity in the PID group and with IgA serum level in the RRTI group.
  
  
  CONCLUSIONS
  Our results show evidence that there is a relationship between ghrelin and nutritional status of healthy children but not in children with PID or RRTI.
authors.affiliation: Third Department and Clinic of Paediatrics, Immunology and Rheumatology of Developmental Age, Wroclaw Medical University, al. Kasprowicza 64/66, 51-137 Wroclaw, Poland. daiva.gorczyca@am.wroc.pl
authors.forename: Daiva
authors.initials: D
authors.lastname: Gorczyca
authors.forename: Barbara
authors.initials: B
authors.lastname: Basiewicz-Worsztynowicz
authors.forename: Daria
authors.initials: D
authors.lastname: Augustyniak
authors.forename: Wieslawa
authors.initials: W
authors.lastname: Karnas-Kalemba
authors.forename: Hanna
authors.initials: H
authors.lastname: Cebula
authors.forename: Adam
authors.initials: A
authors.lastname: Jankowski
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D005260:Female; D054439:Ghrelin / Q000032:analysis / Q000097:blood*; D006801:Humans; D007109:Immunity / Q000502:physiology*; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D008297:Male; D009752:Nutritional Status / Q000502:physiology*; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology
chemical_list: D054439:Ghrelin