title: Medulloblastomics: the end of the beginning.
abstract: The division of medulloblastoma into different subgroups by microarray expression profiling has dramatically changed our perspective of this malignant childhood brain tumour. Now, the availability of next-generation sequencing and complementary high-density genomic technologies has unmasked novel driver mutations in each medulloblastoma subgroup. The implications of these findings for the management of patients are readily apparent, pinpointing previously unappreciated diagnostic and therapeutic targets. In this Review, we summarize the 'explosion' of data emerging from the application of modern genomics to medulloblastoma, and in particular the recurrent targets of mutation in medulloblastoma subgroups. These data are currently making their way into clinical trials as we seek to integrate conventional and molecularly targeted therapies.
authors.affiliation: Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg                 69120, Germany.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Northcott
authors.forename: David T W
authors.initials: DT
authors.lastname: Jones
authors.forename: Marcel
authors.initials: M
authors.lastname: Kool
authors.forename: Giles W
authors.initials: GW
authors.lastname: Robinson
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Gilbertson
authors.forename: Yoon-Jae
authors.initials: YJ
authors.lastname: Cho
authors.forename: Scott L
authors.initials: SL
authors.lastname: Pomeroy
authors.forename: Andrey
authors.initials: A
authors.lastname: Korshunov
authors.forename: Peter
authors.initials: P
authors.lastname: Lichter
authors.forename: Michael D
authors.initials: MD
authors.lastname: Taylor
authors.forename: Stefan M
authors.initials: SM
authors.lastname: Pfister
mesh_terms: D000818:Animals; D002528:Cerebellar Neoplasms / Q000235:genetics* / Q000378:metabolism; D002648:Child; D051361:Cyclin-Dependent Kinase 6 / Q000235:genetics; D004252:DNA Mutational Analysis; D005260:Female; D055106:Genome-Wide Association Study; D023281:Genomics / Q000379:methods; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D009154:Mutation; D015398:Signal Transduction; D057891:Tetraploidy; D051176:beta Catenin / Q000235:genetics
chemical_list: C495270:CTNNB1 protein, human; D053823:Hedgehog Proteins; D006657:Histones; C509239:SHH protein, human; D051176:beta Catenin; C495911:CDK6 protein, human; D051361:Cyclin-Dependent Kinase 6