title: miRNAs, polyphenols, and chronic disease.
abstract: MicroRNAs (miRNAs) are small noncoding RNAs, approximately 18-25 nucleotides in length, that modulate gene expression at the posttranscriptional level. Thousands of miRNAs have been described, and it is thought that they regulate some aspects of more than 60% of all human cell transcripts. Several polyphenols have been shown to modulate miRNAs related to metabolic homeostasis and chronic diseases. Polyphenolic modulation of miRNAs is very attractive as a strategy to target numerous cell processes and potentially reduce the risk of chronic disease. Evidence is building that polyphenols can target specific miRNAs, such as miR-122, but more studies are necessary to discover and validate additional miRNA targets.
authors.affiliation: Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain. mariacinta.blade@urv.cat
authors.forename: Cinta
authors.initials: C
authors.lastname: Bladé
authors.forename: Laura
authors.initials: L
authors.lastname: Baselga-Escudero
authors.forename: Maria Josepa
authors.initials: MJ
authors.lastname: Salvadó
authors.forename: Anna
authors.initials: A
authors.lastname: Arola-Arnal
mesh_terms: D050156:Adipogenesis / Q000235:genetics; D000596:Amino Acids / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control*; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control*; D005234:Fatty Liver / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control*; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control*; D059808:Polyphenols / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D035683:MicroRNAs; D059808:Polyphenols; D005947:Glucose