title: [Intramuscular myxoma of the lower leg].
abstract: The intramuscular myxoma is a rare benign soft tissue tumor characterized by bland spindle-shaped and stellate cells embedded in hypovascular myxoid stroma. We report the isolated case of a 44-year-old female patient with an intramuscular myxoma in the anterior tibial muscle and report the clinical and radiographic findings. We performed an analysis of the GNAS gene mutation status with a positive finding. In difficult cases, recurrent tumors or small biopsies detection of a GNAS mutation can be useful to confirm the diagnosis of an intramuscular myxoma.
authors.affiliation: Institut für Pathologie, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany.
authors.forename: A M
authors.initials: AM
authors.lastname: Luebke
authors.forename: C
authors.initials: C
authors.lastname: Gocke
authors.forename: M
authors.initials: M
authors.lastname: Priemel
authors.forename: T J
authors.initials: TJ
authors.lastname: Grob
authors.forename: J
authors.initials: J
authors.lastname: Zustin
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000235:genetics; D002864:Chromogranins; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005260:Female; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics; D006801:Humans; D033162:Incidental Findings; D008279:Magnetic Resonance Imaging; D019042:Muscle Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D018482:Muscle, Skeletal / Q000473:pathology* / Q000601:surgery; D009232:Myxoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000235:genetics
chemical_list: D018952:Antigens, CD34; D002864:Chromogranins; D014746:Vimentin; C406732:GNAS protein, human; D019205:GTP-Binding Protein alpha Subunits, Gs