title: [Research progress of bone morphogenetic protein and liability of ossification of posterior longitudinal ligament].
abstract: OBJECTIVE
  To review the research progress of bone morphogenetic protein (BMP) and the liability of ossification of the posterior longitudinal ligament (OPLL).
  
  
  METHODS
  Recent literature concerning BMP and the liability of OPLL was reviewed, analysed, and summarized.
  
  
  RESULTS
  The single nucleotide polymorphisms (SNPs) of BMP gene may produce a minor cumulative effect and increase individual susceptibility to OPLL. A variety of environmental factors can promote the occurrence and development of OPLL by increasing the expression of BMP gene.
  
  
  CONCLUSIONS
  The SNPs of BMP gene may increase individual susceptibility to OPLL. However, interaction of cumulative effect of the SNPs and environmental factors can promote the liability to OPLL.
authors.affiliation: Department of Spinal Surgery, Nankai University Affiliated Hospital, Tianjin 300121, PR China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Fang
authors.forename: Tianwei
authors.initials: T
authors.lastname: Sun
authors.forename: Sandip Kumar
authors.initials: SK
authors.lastname: Yadav
mesh_terms: D055396:Bone Morphogenetic Protein 2 / Q000235:genetics; D055415:Bone Morphogenetic Protein 4 / Q000235:genetics; D019485:Bone Morphogenetic Proteins / Q000235:genetics*; D005785:Gene Conversion; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D017887:Ossification of Posterior Longitudinal Ligament / Q000235:genetics*; D010006:Osteoblasts / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide
chemical_list: D055396:Bone Morphogenetic Protein 2; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins