title: Langerhans cells come in waves.
abstract: It is unclear how the Langerhans cell (LC) network is maintained in adult epidermis. In this issue of Immunity, Seré et al. (2012) show that LCs are replenished in two waves. Monocyte-derived, short-lived LCs come first. A second wave follows, and these LCs of nonmonocytic origin are long-lived.
authors.affiliation: Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria. nikolaus.romani@i-med.ac.at
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Romani
authors.forename: Christoph H
authors.initials: CH
authors.lastname: Tripp
authors.forename: Patrizia
authors.initials: P
authors.lastname: Stoitzner