title: Lipofuscin and the principles of fundus autofluorescence: a review.
abstract: Fundus autofluorescence is a non-invasive imaging modality that measures lipofuscin that has accumulated in the retinal pigment epithelium (RPE). Excessive lipofuscin in the RPE is a common pathway found in several diseases including Stargardt's disease and age-related macular degeneration. This review discusses the role of photooxidative damage in the development of lipofuscin and the principles of fundus autofluorescence.
authors.affiliation: Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
authors.forename: Namrata
authors.initials: N
authors.lastname: Nandakumar
authors.forename: Sheldon
authors.initials: S
authors.lastname: Buzney
authors.forename: John J
authors.initials: JJ
authors.lastname: Weiter
mesh_terms: D000818:Animals; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D057092:Geographic Atrophy / Q000378:metabolism; D006801:Humans; D008027:Light; D008062:Lipofuscin / Q000378:metabolism*; D008268:Macular Degeneration / Q000378:metabolism; D061848:Optical Imaging; D018384:Oxidative Stress / Q000528:radiation effects; D055213:Retinal Pigment Epithelium / Q000378:metabolism*
chemical_list: D008062:Lipofuscin