title: Synthesis of novel pyrrolyl-indomethacin derivatives.
abstract: In the present work, we report the synthesis of the novel esters of indomethacin (IDMC) and an ester of reduced IDMC. For this purpose, IDMC is covalently bound by using a spacer chain to the pyrrole (Py) in the 3-position. The innovative pyrrole-indomethacin (3-Py-IDMC) derivates show no cytotoxic effects in primary calvarial osteoblasts. The designed IDMC derivates have been studied because they could be injected locally as a component of polymeric micro-particles. In fact, the new 3-Py-IDMC derivatives will assure their further polymerization since the 2- and 5-monomer positions are free.
authors.affiliation: Chemistry Department, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
authors.forename: Judith
authors.initials: J
authors.lastname: Serra Moreno
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Agas
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Sabbieti
authors.forename: Matteo
authors.initials: M
authors.lastname: Di Magno
authors.forename: Antonella
authors.initials: A
authors.lastname: Migliorini
authors.forename: M Antonietta
authors.initials: MA
authors.lastname: Loreto
mesh_terms: D000199:Actins / Q000737:chemistry; D000818:Animals; D000831:Animals, Newborn; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000494:pharmacology; D004952:Esters; D006651:Histocytochemistry; D007213:Indomethacin / Q000737:chemistry*; D007270:Injections, Intra-Articular; D008297:Male; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010084:Oxidation-Reduction; D061251:Primary Cell Culture; D011758:Pyrroles / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012886:Skull / Q000166:cytology / Q000187:drug effects
chemical_list: D000199:Actins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004952:Esters; D011758:Pyrroles; D007213:Indomethacin