title: [Clinical study on hemangiomas treatment with high-intensity focused ultrasound (60 cases)].
abstract: OBJECTIVE
  To explore the clinical effect and appropriate power of high-intensity focused ultrasound (HIFU) in the treatment of infant hemangioma.
  
  
  METHODS
  80 infants with hemangioma were randomly divided into four groups, 20 cases in each group. All cases in group A, B and C were irradiated on the lesion surface with 3-5 mm/s speed for five continuous come-and-goes using HIFU, with frequency 9 MHz, impulse 1 000 Hz and 10% scanning overlap. The power was respectively 3.5 W in group A, 4.0 W in group B and 4.5 W in group C. One session contained three times of treatment, with one month interval. The cases in group D were only followed up as control group. The therapeutic effect, ulcer and scar in irradiated region in group A, B, C were observed 6 months after the last treatment, which were synchronously compared with those in group D.
  
  
  RESULTS
  6 months after the last treatment, 7, 9, 8 cases were cured and 9, 8, 10 cases were almost cured, and 4, 3, 2 cases got improved in group A, B, C, respectively. The total effective rate was 100% in the three groups. While only 5 cases got improved in group D. The treatment effect in group A, B and C was obviously better than that in group D (P < 0.05), with no significant difference among the three groups statistically (P > 0.05). Ulcer and scar in irradiated skin occurred in 0,4,6,0 cases in group A, B, C and D, respectively. The incidence of ulcer and scar was obviously higher in group B and C than that in group A and D statistically (P < 0.05).
  
  
  CONCLUSIONS
  HIFU irradiating is one of effective methods for infant hemangioma treatment. The appropriate power should not be above 3.5 W.
authors.affiliation: Cosmetic and Plastic Department, Jiangxi Women and Children Health Care Hospital, Nanchang 330006, China.
authors.forename: Shi-Zhang
authors.initials: SZ
authors.lastname: Fu
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: He-Ping
authors.initials: HP
authors.lastname: Huang
authors.forename: Lin-Ling
authors.initials: LL
authors.lastname: Huang
mesh_terms: D005260:Female; D006391:Hemangioma / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*