title: Total spontaneous resolution by deracemization of isoindolinones.
abstract: Separated: 3-hydroxy-3-phenylisoindolin-1-ones have been resolved by dynamic preferential crystallization. The compounds were effectively racemized through ring-opening and ring-closing reactions via achiral intermediates under basic conditions. Crystallization from a toluene solution containing 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) with stirring and evaporation of the solvent gave optically active crystals quantitatively with high ee values.
authors.affiliation: Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Yayoi-cho, Inage-ku, Japan.
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Yagishita
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Onuki
authors.forename: Shoko
authors.initials: S
authors.lastname: Hachiya
authors.forename: Takashi
authors.initials: T
authors.lastname: Mino
authors.forename: Masami
authors.initials: M
authors.lastname: Sakamoto