title: Impact of Factor V Leiden, prothrombin and methylenetetrahydrofolate reductase gene mutations on infant birth weight in women with recurrent fetal loss and women with successful pregnancies.
abstract: OBJECTIVE
  The aim of this study was to verify whether FV Leiden, PT G20210A, MTHFR C667T or MTHFR A1298C mutations influence the risk of recurrent fetal loss in a sample of Turkish women who had experienced recurrent fetal loss and to evaluate whether the aforementioned thrombophilias and recurrent fetal loss may affect the birth weight of subsequent pregnancies.
  
  
  METHODS
  Fifty-eight women with recurrent pregnancy loss and 30 women with successful pregnancies were evaluated.
  
  
  RESULTS
  The average birth weights for infants of all women in the study group and for infants of thrombophilia-positive women in the study group were markedly lower than the birth weight of infants in the control group (p<0.001 and p<0.001, respectively).
  
  
  CONCLUSIONS
  Successful pregnancies in women with a history of recurrent fetal losses may be associated with lower birth weights compared to controls, irrespective of thrombophilia status. This conclusion warrants further research.
authors.affiliation: Department of Obstetrics and Gynecology, Kent Hospital, Izmir, Turkey. candatunc@yahoo.com
authors.forename: M T
authors.initials: MT
authors.lastname: Canda
authors.forename: N
authors.initials: N
authors.lastname: Demir
authors.forename: O
authors.initials: O
authors.lastname: Sezer
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D001724:Birth Weight / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000235:genetics; D011516:Prothrombin / Q000235:genetics*; D019851:Thrombophilia / Q000235:genetics; D014421:Turkey
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)