title: Dioxaphosphorinane-constrained nucleic Acid dinucleotides as tools for structural tuning of nucleic acids.
abstract: We describe a rational approach devoted to modulate the sugar-phosphate backbone geometry of nucleic acids. Constraints were generated by connecting one oxygen of the phosphate group to a carbon of the sugar moiety. The so-called dioxaphosphorinane rings were introduced at key positions along the sugar-phosphate backbone allowing the control of the six-torsion angles α to ζ defining the polymer structure. The syntheses of all the members of the D-CNA family are described, and we emphasize the effect on secondary structure stabilization of a couple of diastereoisomers of α,β-D-CNA exhibiting wether B-type canonical values or not.
authors.affiliation: Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, CNRS UMR 5068, Université Paul Sabatier, 31062 Toulouse, France.
authors.forename: Dan-Andrei
authors.initials: DA
authors.lastname: Catana
authors.forename: Brice-Loïc
authors.initials: BL
authors.lastname: Renard
authors.forename: Marie
authors.initials: M
authors.lastname: Maturano
authors.forename: Corinne
authors.initials: C
authors.lastname: Payrastre
authors.forename: Nathalie
authors.initials: N
authors.lastname: Tarrat
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Escudier