title: Accumulation of plasma 3-deoxyglucosone impaired glucose regulation in Chinese seniors: implication for senile diabetes?
abstract: OBJECTIVE
  To investigate the impact of increasing accumulation of 3-deoxyglucosone (3-DG) on glucose regulation in non-diabeteic seniors.
  
  
  METHODS
  This research is a 2-year prospective follow-up study. We conducted a HPLC assay to determine the plasma 3-DG concentrations of 132 non-diabetic retirees of Suzhou. An oral glucose tolerance test was carried out 2 years after baseline in 16 subjects with continual high plasma 3-DG and 16 control subjects randomly sampled in those with normal plasma 3-DG.
  
  
  RESULTS
  The median plasma 3-DG level of 132 subjects was 43.52 ng/ml (7.89-736.09 ng/ml), of which 47 subjects (36.6%) were beyond 70 ng/ml. A correlation between age and 3-DG was found among people between 50 and 66 years old (r=0.408, P<0.001). The 60-69 years group had a higher 3-DG level than 50-59 years group (P<0.001). Compared with control group, the continual high plasma 3-DG subjects had a higher level of FINs (P<0.05), FBG (P<0.01), HOMA-IR (P<0.001), and a lower level of ISI (P<0.001) and ΔI(60)/ΔG(60) (P<0.05), as well as a higher incidence of impaired glucose regulation (χ(2)=7.814, P<0.05).
  
  
  CONCLUSIONS
  There was abnormal elevation of plasma 3-DG in non-diabetic seniors, and the increasing accumulation of plasma 3-DG, which mainly resulted from aging, eventually lead to the impaired glucose regulation, indicating an association of 3-DG with senile diabetes.
authors.affiliation: Institute of Traditional Chinese Medicine, Suzhou Traditional Chinese Medicine Hospital, Suzhou, China.
authors.forename: Guorong
authors.initials: G
authors.lastname: Jiang
authors.forename: Lurong
authors.initials: L
authors.lastname: Zhang
authors.forename: Qingling
authors.initials: Q
authors.lastname: Ji
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Heng
authors.initials: H
authors.lastname: Xu
authors.forename: Fei
authors.initials: F
authors.lastname: Huang
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Wang
mesh_terms: D000367:Age Factors; D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000208:ethnology; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000097:blood* / Q000453:epidemiology; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D003847:Deoxyglucose; C016350:3-deoxyglucosone