title: Mitochondria-targeted plastoquinone antioxidant SkQR1 decreases trauma-induced neurological deficit in rat.
abstract: A protective effect of a mitochondria-targeted antioxidant, a cationic rhodamine derivative linked to a plastoquinone molecule (10-(6'-plastoquinonyl)decylrhodamine-19, SkQR1) was studied in the model of open focal trauma of rat brain sensorimotor cortex. It was found that daily intraperitoneal injections of SkQR1 (100 nmol/kg) for 4 days after the trauma improved performance in a test characterizing neurological deficit and decreased the volume of the damaged cortical area. Our results suggest that SkQR1 exhibits profound neuroprotective effect, which may be explained by its antioxidative activity.
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia. isaev@genebee.msu.ru
authors.forename: N K
authors.initials: NK
authors.lastname: Isaev
authors.forename: S V
authors.initials: SV
authors.lastname: Novikova
authors.forename: E V
authors.initials: EV
authors.lastname: Stelmashook
authors.forename: I V
authors.initials: IV
authors.lastname: Barskov
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
authors.forename: L G
authors.initials: LG
authors.lastname: Khaspekov
authors.forename: V P
authors.initials: VP
authors.lastname: Skulachev
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D001930:Brain Injuries / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000378:metabolism* / Q000494:pharmacology*; D010971:Plastoquinone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012235:Rhodamines / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: C534903:10-(6'-plastoquinonyl) decylrhodamine 19; D000975:Antioxidants; D018696:Neuroprotective Agents; D012235:Rhodamines; D010971:Plastoquinone