title: [Impact of hypoxen therapy on postoperative course in gynecologic patients].
abstract: The aim of the study was to estimate the use of hypoxen (antihypoxant) during the early postoperative course in gynecologic patients. The patients were divided into two groups according to the treatment scheme. 339 patients of the control group were under the routine therapy after the laparatomic gynecologic operations. 52 patients were additionally treated with hypoxen (antioxidant) (the main group). The impact of hypoxen on the antioxidant system and lipid peroxidation and its preventive effect on prolongation of the postoperative pain syndrom were estimated. The results of the study showed that hypoxen inhibited lipid peroxidation and activated the antioxidant system in the postoperative patients vs. the control group. It was also observed that among the patients additionally treated with hypoxen the percentage of those with prolonged postoperative pains was statistically lower (p<0.05, chi2 test). It was concluded that hypoxen normalized lipid peroxidation and antioxidant system after abdominal gynecologic operations. The additional use of hypoxen in the routine therapy of the gynecologic patients prevented prolongation of the postoperative pain syndrom.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Dugieva
authors.forename: K V
authors.initials: KV
authors.lastname: Kotenko
authors.forename: K V
authors.initials: KV
authors.lastname: Morozova
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D010149:Postoperative Pain / Q000188:drug therapy* / Q000517:prevention & control*; D010647:Phenyl Ethers / Q000627:therapeutic use*; D013997:Time Factors; D055815:Young Adult
chemical_list: D010647:Phenyl Ethers; C085806:olifen