title: Generalized flare of pustular psoriasis induced by PEGylated interferon-α2b therapy for chronic hepatitis C.
abstract: New onset or exacerbation of psoriasis vulgaris has been reported in a small number of patients after interferon (IFN)-α therapy. Herein, we report a case of generalized flare of pustular psoriasis induced by PEGylated IFN-α2b (PEG-IFN-α2b) in a 59-year-old woman with a 15-year history of pustular psoriasis and chronic hepatitis C. Interferon-α therapy was discontinued and the rash resolved after treatment with cyclosporin and systemic methylprednisolone. The potential side effect of PEG-IFN-α2b in inducing or exacerbating psoriasis should be kept in mind when treating patients with a history of psoriasis or pustular psoriasis.
authors.affiliation: Department of Dermatology, National Cheng Kung University Medical College and Hospital, 138 Sheng-Li Road, Tainan, Taiwan.
authors.forename: Meng-Chi
authors.initials: MC
authors.lastname: Wu
authors.forename: J Yu-Yun
authors.initials: JY
authors.lastname: Lee
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects*; D018450:Disease Progression; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011565:Psoriasis / Q000139:chemically induced*; D011994:Recombinant Proteins / Q000009:adverse effects
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C417083:peginterferon alfa-2b