title: Magnetic resonance imaging for extramammary Paget's disease: radiological and pathological correlations.
abstract: Extramammary Paget's disease (EMPD) is a rare cutaneous neoplasm that is thought to represent intraepithelial adenocarcinoma developing in an area rich in apocrine glands. Magnetic resonance imaging (MRI) findings for this disease are not well established. We report three cases of pathologically confirmed EMPD in which MRI was performed before surgery. The lesions were widespread in the epidermis and the dermis. Lesions were sharply well enhanced on gadolinium-enhanced T1-weighted imaging and appeared hyperintense on diffusion-weighted imaging in all cases. Areas with enhancement in depth corresponded well with the pathological lesion. In addition, different malignant legions were found on the same images from MRI in two cases, indicating potential associations with other malignancies. We describe the MRI findings and their pathological correlation. MRI could be useful for preoperative evaluation of disease spread and detection of associated malignancies.
authors.affiliation: Department of Radiology, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan. akagnsk@luke.or.jp
authors.forename: Gensuke
authors.initials: G
authors.lastname: Akaike
authors.forename: Taiki
authors.initials: T
authors.lastname: Nozaki
authors.forename: Masaki
authors.initials: M
authors.lastname: Matsusako
authors.forename: Mizuko
authors.initials: M
authors.lastname: Matsui
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Ohtake
authors.forename: Hikaru
authors.initials: H
authors.lastname: Eto
authors.forename: Koyu
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Saida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010145:Paget Disease, Extramammary / Q000175:diagnosis*; D012878:Skin Neoplasms / Q000175:diagnosis*; D013223:Statistics as Topic; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*