title: Relationship between GSTT1 gene polymorphism and hepatocellular carcinoma in patients from China.
abstract: OBJECTIVE
  The results from studies on associations of the glutathione S-transferase T1 (GSTT1) gene polymorphism and hepatocellular carcinoma (HCC) risk in Chinese populations are still conflicting. This meta- analysis was performed to evaluate the relationship in detail.
  
  
  METHODS
  Eligible reports were recruited into this meta-analysis from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database). Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated.
  
  
  RESULTS
  Eighteen investigations were identified for the analysis of association between polymorphic deletion of GSTT1 and HCC, consisting of 2,693 patients with HCC and 4,696 controls. Null genotype of GSTT1 was associated with HCC susceptibility in Chinese (OR=1.53, 95%CI: 1.28-1.82; P<0.00001).
  
  
  CONCLUSIONS
  The GSTT1 null genotype is associated with HCC susceptibility in Chinese.
authors.affiliation: Department of Hepatobiliary Surgery, The Tumor Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Ma
authors.forename: Ning-Fu
authors.initials: NF
authors.lastname: Peng
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Wang
authors.forename: Le-Qun
authors.initials: LQ
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002681:China; D016001:Confidence Intervals; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase