title: [Paradoxical reaction to salbutamol in an asthma patient].
abstract: Bronchial asthma is a disease with increasing incidence worldwide, being an important cause of morbidity and mortality. The diagnosis and management of the disease are subject to international guidelines, GINA being updated periodically, according to the latest findings about the disease. The recommendations include the use in all severity stages of short acting beta-2-agonists as reliever of asthma symptoms. We present the case of an asthma patient presenting a life-threatening paradoxical bronchospasm at salbutamol, as well as discussions on the possible pathogenesis of this situation. Paradoxical bronchospasm to salbutamol is a rare situation but can turn into a serious problem for the patient, as well as for the physicians who underestimate this possibility.
authors.affiliation: Institutul de Pneumologie "Marius Nasta" Bucureşti. istrambu@yahoo.com
authors.forename: Irina
authors.initials: I
authors.lastname: Strâmbu
authors.forename: Roxana
authors.initials: R
authors.lastname: Bumbăcea
mesh_terms: D000368:Aged; D000420:Albuterol / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000150:complications* / Q000188:drug therapy; D001986:Bronchial Spasm / Q000139:chemically induced*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D005280:Fenoterol / Q000008:administration & dosage; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage; D008297:Male; D012135:Respiratory Sounds / Q000209:etiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D001993:Bronchodilator Agents; D004338:Drug Combinations; C030809:fenoterol, ipratropium drug combination; D005280:Fenoterol; D009241:Ipratropium; D000420:Albuterol