title: Association of microsatellite instability and chronic obstructive pulmonary disorder in isocyanate-Exposed population of Bhopal.
abstract: BACKGROUND
  Survivors of the Bhopal gas disaster still suffer from various respiratory ailments. We examined the effects of exposures among a cross-section of current residents suffering from COPD by ISSR-PCR.
  
  
  OBJECTIVE
  Molecular screening of the gas-affected population of Bhopal with COPD for microsatellite instability due to exposure of MIC.
  
  
  METHODS
  The isocyanate-exposed population of Bhopal city suffering from chronic obstructive pulmonary disorder.
  
  
  METHODS
  Inter-(SSR) analysis was used to characterize microsatellite instability in 52 MIC victims of Bhopal, suffering from COPD using (CA)(8)RG and (CA)(8)R[Y-Q] primer.
  
  
  METHODS
  Association analyses were performed using regression analysis.
  
  
  RESULTS
  The study on the MIC-affected population in Bhopal showed weak association between microsatellite instability and age (r = + 0.37); exposure distance from site (r = -0.44); and smoking status(r = + 0.12); while regression analysis of the above parameters displayed supporting evidence.
  
  
  CONCLUSIONS
  The high prevalence of smoking coupled with aging and poor living habits threatens, to further increase COPD incidences among this population, highlighting the need for enhanced screening efforts.
authors.affiliation: Department of Research, Cell and Molecular Biology Lab, Bhopal Memorial Hospital and Research Center, Karond Bye-pass Road, Bhopal, Madhya Pradesh, India.
authors.forename: Protiti
authors.initials: P
authors.lastname: Bose
authors.forename: Rashmi
authors.initials: R
authors.lastname: Bathri