title: MTHFR 677T variant contributes to diabetic nephropathy risk in Caucasian individuals with type 2 diabetes: a meta-analysis.
abstract: OBJECTIVE
  Previous studies regarding the association between 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and diabetic nephropathy (DN) risk in Caucasian individuals with type 2 diabetes reported conflicting results. To derive a more precise estimation of this association, a meta-analysis was performed.
  
  
  METHODS
  Odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) were pooled to assess the association between MTHFR C677T polymorphism and DN risk. Finally, 10 case-control studies with a total of 1590 DN cases and 1555 type 2 diabetic controls without DN were included.
  
  
  RESULTS
  Overall, there was an association between MTHFR C677T polymorphism and increased risk of DN under four comparison models (OR T vs. C=1.50, 95% CI 1.07-2.02, P=0.02; OR TT vs. CC=2.09, 95% CI 1.07-4.08, P=0.03; OR TT vs. TC+CC=1.70, 95% CI 1.10-2.63, P=0.017; OR TC+TT vs. CC=1.85, 95% CI 1.19-2.88, P=0.006). Sensitivity analysis suggested exclusion of any single study did not materially alter the overall pooled ORs above.
  
  
  CONCLUSIONS
  This meta-analysis supports that there is an association between MTHFR C677T polymorphism and DN risk, and MTHFR 677T variant contributes to increased risk of DN in Caucasian individuals with type 2 diabetes.
authors.affiliation: Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang 110004, China. yangsh19@yahoo.com.cn
authors.forename: Sheng
authors.initials: S
authors.lastname: Yang
authors.forename: Jingwen
authors.initials: J
authors.lastname: Zhang
authors.forename: Chang
authors.initials: C
authors.lastname: Feng
authors.forename: Guoliang
authors.initials: G
authors.lastname: Huang
mesh_terms: D000368:Aged; D016001:Confidence Intervals; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D017594:Publication Bias; D012306:Risk; D044465:White People
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)