title: [Expression of miR-216a in pancreatic cancer and its clinical significance].
abstract: OBJECTIVE
  To explore the clinical significance of miRNA-216a expression in pancreatic cancer.
  
  
  METHODS
  Fourteen patients with pancreatic cancer undergoing pancreaticoduodenectomy and 6 patients with benign pancreas lesions were examined for miR-216a expressions in the tumor or lesion tissues using Agilent Human miRNA Microarray (V12.0). The relationship between miR-216a expressions and the clinicopathological features of the patients was analyzed.
  
  
  RESULTS
  The expression of miRNA-216a was significantly lower in pancreatic cancer than in benign pancreas lesions (P=0.000). The expression of miRNA-216a was significantly correlated with the T stage of the tumor (P=0.002), but not with the patients' age, gender, smoking status, tumor stage, lymph node metastases, distant metastasis, tumor differentiation, nerve invasion, vessel invasion or serum CA19-9 level (P>0.05).
  
  
  CONCLUSIONS
  The down-regulated expression of miR-216a in pancreatic cancer suggests the involvement of miR-216a in the tumorigenesis and development of pancreatic cancer. miR-216a may potentially serve as a novel tumor marker and also a prognostic factor for pancreatic cancer.
authors.affiliation: First Department of General Surgery, Guangdong Academy of Medical Sciences, Guangzhou, China. hbh1000@126.com
authors.forename: Baohua
authors.initials: B
authors.lastname: Hou
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Jian
authors.forename: Sicong
authors.initials: S
authors.lastname: Chen
authors.forename: Yingliang
authors.initials: Y
authors.lastname: Ou
authors.forename: Shaojie
authors.initials: S
authors.lastname: Li
authors.forename: Jinrui
authors.initials: J
authors.lastname: Ou
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: C575482:MIRN216 microRNA, human; D035683:MicroRNAs