title: Synthesis of vertex-differentiated icosahedral closo-boranes: polyfunctional scaffolds for targeted drug delivery.
abstract: We report methods for the synthesis of vertex-differentiated icosahedral closo-boranes. A single B-OH vertex of the icosahedral borane [closo-B(12)(OH)(12)](2-) was derivatized to prepare [closo-B(12)(OR)(OH)(11)](2-) using optimized alkylation conditions and purification procedures. Several representative vertex-differentiated icosahedral closo-boranes were prepared utilizing carbonate ester and azide-alkyne click chemistries on the surface of the closo-B(12)(2-) core.
authors.affiliation: International Institute of Nano and Molecular Medicine, School of Medicine, University of Missouri, Columbia, Missouri 65211-3450, USA.
authors.forename: Lalit N
authors.initials: LN
authors.lastname: Goswami
authors.forename: Zachary H
authors.initials: ZH
authors.lastname: Houston
authors.forename: Saurav J
authors.initials: SJ
authors.lastname: Sarma
authors.forename: Hairong
authors.initials: H
authors.lastname: Li
authors.forename: Satish S
authors.initials: SS
authors.lastname: Jalisatgi
authors.forename: M Frederick
authors.initials: MF
authors.lastname: Hawthorne
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D001880:Boranes / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D057930:Click Chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D001880:Boranes; D004337:Drug Carriers