title: Novel triterpenoid saponins from the seeds of Celosia argentea L.
abstract: Two new triterpenoid saponins celosin I (1) and celosin II (2) were isolated from the seeds of Celosia argentea L. (Amaranthaceae). The structures of the two new compounds were elucidated based on chemical analysis and spectral methods (IR, 1-D and 2-D NMR, ESI-MS, HR-ESI-MS). They exhibited significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Qing Bin
authors.initials: QB
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Liang
authors.forename: Qian
authors.initials: Q
authors.lastname: Jiang
authors.forename: Mei Li
authors.initials: ML
authors.lastname: Guo
authors.forename: Jun Jie
authors.initials: JJ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D034762:Celosia / Q000737:chemistry*; D008099:Liver / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000633:toxicity; D012639:Seeds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D012503:Saponins; D014315:Triterpenes