title: Adiponectin, leptin and ghrelin levels in obese adolescent girls with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate the differences in adipokines, namely adiponectin, leptin, and ghrelin, in obese adolescent girls with or without polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  38 adolescent girls (age 15-20 years). Group I: 17 Obese adolescent girls with PCOS (BMI ≥ 30 kg/m(2)); Group II: Control group of 21 obese adolescent girls (BMI ≥ 30 kg/m(2)).
  
  
  METHODS
  Adiponectin, leptin, and ghrelin measurements.
  
  
  RESULTS
  LH, LH/FSH, and cortisol levels were significantly higher in the obese PCOS girls compared to the obese controls (6.94 ± 3.28 vs 4.44 ± 1.79; 1.50 ± 0.72 vs 0.90 ± 0.36; 16.02 ± 4.28 vs 12.46 ± 5.29; P < .05, respectively). Adiponectin, leptin, and ghrelin levels were similar between the obese PCOS girls and the obese controls (11.13 ± 6.00 vs 15.26 ± 12.66; 23.66 ± 11.54 vs 23.11 ± 11.17; 665.69 ± 402.12 vs 650.22 ± 467.73, respectively). Adiponectin negatively correlated with BMI (r = -0.32; P = .04) and positively correlated with fasting glucose (r = 0.40; P = .01). Leptin positively correlated with BMI (r = 0.534; P = .001), estradiol (r = 0.354; P = .02), and TSH (r = 0.374; P = .02). No significant correlation was found between ghrelin and the test parameters.
  
  
  CONCLUSIONS
  Among obese adolescents with PCOS, adiponectin, and leptin levels do not seem to be determined by the existence of PCOS, while ghrelin presents no significant correlation.
authors.affiliation: Department of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Kale-Gurbuz
authors.forename: Suleyman Engin
authors.initials: SE
authors.lastname: Akhan
authors.forename: Ercan
authors.initials: E
authors.lastname: Bastu
authors.forename: Aysegul
authors.initials: A
authors.lastname: Telci
authors.forename: Ahmet Cem
authors.initials: AC
authors.lastname: Iyibozkurt
authors.forename: Samet
authors.initials: S
authors.lastname: Topuz
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D016022:Case-Control Studies; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D052242:Adiponectin; D054439:Ghrelin; D020738:Leptin