title: Platelet glycoprotein IaC807T polymorphisms and ischemic stroke in young Chinese Han population.
abstract: OBJECTIVE
  The objective of this study was to investigate the association between platelet glycoprotein (GP) Ia C807T polymorphisms and ischemic stroke in young Chinese Han Population.
  
  
  METHODS
  We conducted a case-control study in 92 consecutive young (</= 50 years) first-ever hospitalized ischemic stroke inpatients and outpatients, 86 elder ischemic stroke control (> 50 years), and 160 age- and sex-matched healthy control. Genotyping of platelet GP Ia C807Tpolymorphisms was performed by polymerase chain reaction followed by sequencing nucleic acid with dideoxy chain-termination method and an ABI PRISM3100 (Perkin-Elmer Co) genetic analyzer. Student's t-test, chi-square test, and logistic regression modeling were used for data significance analyses.
  
  
  RESULTS
  Hypertension and smoking were found to be the independent risk factors for ischemic stroke patients (aged </= 50 years), while hypertension, diabetes and smoking were the independent risk factors for ischemic stroke patients (aged > 50 years). There was no significant difference observed in the T allele frequency of GPIa C807T polymorphisms between young stroke patients and corresponding controls.
  
  
  CONCLUSIONS
  These findings suggest that there is no role of GPIa C807T polymorphisms in the development of young first-ever ischemic stroke in Chinese Han Population.
authors.affiliation: Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: H
authors.initials: H
authors.lastname: An
authors.forename: R
authors.initials: R
authors.lastname: Ojha
authors.forename: C
authors.initials: C
authors.lastname: DU
authors.forename: R
authors.initials: R
authors.lastname: Liu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002545:Brain Ischemia / Q000150:complications / Q000235:genetics*; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics; D039421:Integrin alpha2 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000235:genetics; D020521:Stroke / Q000150:complications / Q000235:genetics*
chemical_list: D039421:Integrin alpha2