title: Overexpression of p-4ebp1 in Chinese gastric cancer patients and its correlation with prognosis.
abstract: OBJECTIVE
  We sought to reveal the status of phosphorylated 4E-binding protein 1 (p-4ebp1) expression in Chinese gastric cancer patients and its correlation with tumor prognosis.
  
  
  METHODS
  Tissue microarray blocks containing gastric cancer tissue and matched noncancerous gastric tissue specimens from 286 patients were constructed. The expression of 4E-binding protein 1 (4ebp1) and p-4ebp1 of these specimens was analyzed using immunohistochemical studies.
  
  
  RESULTS
  The expression rates of 4ebp1 and p-4ebp1 in gastric cancer were 68.5% (196 of 286) and 49.7% (142 of 286) respectively. The expression of 4ebp1 was correlated with node metastasis and poor differentiation, while the expression of p-4ebp1 was correlated with tumor size, node metastasis and TNM stage. p-4ebp1 overexpression has a significant inverse correlation with median survival time.
  
  
  CONCLUSIONS
  p-4ebp1 expression is correlated with later TNM stage and is a prognostic factor of survival time after surgery.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Jiao
authors.forename: Jun
authors.initials: J
authors.lastname: Pan
authors.forename: Jianxin
authors.initials: J
authors.lastname: Qian
authors.forename: Tianhang
authors.initials: T
authors.lastname: Luo
authors.forename: Zhan
authors.initials: Z
authors.lastname: Wang
authors.forename: Guanzhen
authors.initials: G
authors.lastname: Yu
authors.forename: Jiejun
authors.initials: J
authors.lastname: Wang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D018797:Cell Cycle Proteins; D002681:China; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D010750:Phosphoproteins / Q000378:metabolism*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D046888:Tissue Array Analysis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; C087000:EIF4EBP1 protein, human; D010750:Phosphoproteins