title: First attempt to validate human IgG antibody response to Nterm-34kDa salivary peptide as biomarker for evaluating exposure to Aedes aegypti bites.
abstract: BACKGROUND
  Much effort is being devoted for developing new indicators to evaluate the human exposure to Aedes mosquito bites and the risk of arbovirus transmission. Human antibody (Ab) responses to mosquito salivary components could represent a promising tool for evaluating the human-vector contact.
  
  
  RESULTS
  To develop a specific biomarker of human exposure to Aedes aegypti bites, we measured IgG Ab response to Ae. aegypti Nterm-34 kDa salivary peptide in exposed children in 7 villages of Southern Benin (West Africa). Results showed that specific IgG response presented high inter-individual heterogeneity between villages. IgG response was associated with rainfall and IgG level increased from dry (low exposure) to rainy (high exposure) seasons. These findings indicate that IgG Ab to Nterm-34 kDa salivary peptide may represent a reliable biomarker to detect variation in human exposure to Ae. aegypti bites.
  
  
  CONCLUSIONS
  This preliminary study highlights the potential use of Ab response to this salivary peptide for evaluating human exposure to Ae. aegypti. This biomarker could represent a new promising tool for assessing the risk of arbovirus transmission and for evaluating the efficacy of vector control interventions.
authors.affiliation: Institut de Recherche pour le Développement (IRD), Maladies Infectieuses et Vecteurs, Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224 - CNRS 5290 - Universities of Montpellier 1, France. emmanuel.elanga@ird.fr
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Elanga Ndille
authors.forename: Souleymane
authors.initials: S
authors.lastname: Doucoure
authors.forename: Georgia
authors.initials: G
authors.lastname: Damien
authors.forename: François
authors.initials: F
authors.lastname: Mouchet
authors.forename: Papa Makhtar
authors.initials: PM
authors.lastname: Drame
authors.forename: Sylvie
authors.initials: S
authors.lastname: Cornelie
authors.forename: Herbert
authors.initials: H
authors.lastname: Noukpo
authors.forename: Sandra
authors.initials: S
authors.lastname: Yamadjako
authors.forename: Armel
authors.initials: A
authors.lastname: Djenontin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Moiroux
authors.forename: Dorothee
authors.initials: D
authors.lastname: Misse
authors.forename: Martin
authors.initials: M
authors.lastname: Akogbeto
authors.forename: Vincent
authors.initials: V
authors.lastname: Corbel
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Henry
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chandre
authors.forename: Thierry
authors.initials: T
authors.lastname: Baldet
authors.forename: Franck
authors.initials: F
authors.lastname: Remoue
mesh_terms: D000330:Aedes / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D001541:Benin; D015415:Biomarkers; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D007299:Insect Bites and Stings / Q000175:diagnosis*; D019476:Insect Proteins / Q000276:immunology*; D008297:Male; D012471:Salivary Proteins and Peptides / Q000276:immunology
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G; D019476:Insect Proteins; D012471:Salivary Proteins and Peptides