title: A novel biotechnology product for the degradation of biofilm-associated polysaccharides produced by Streptococcus mutans.
abstract: In this study we evaluated the activity of ABR preparation, a first-in-class agent obtained through fermentation process by genetically unmodified Bacillus spp., in breaking down polysaccharide produced by Streptococcus mutans, primary coloniser of tooth surface and abundant in dental biofilms. Our results showed that ABR preparation is able in degrading sugars formed by S. mutans, both in broth culture and onto teeth surface. Its activity is not influenced by the presence of saliva, commercial mouthwashes or oral disinfectants. ABR preparation has the potential to remove preformed plaque and counteract its development, thus offering conservative control of gingival and periodontal disease.
authors.affiliation: Department of Biomedical Sciences, University of Chieti-Pescara, Chieti, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Di Bonaventura
authors.forename: M
authors.initials: M
authors.lastname: Uriani
authors.forename: A
authors.initials: A
authors.lastname: Fabbri
authors.forename: V
authors.initials: V
authors.lastname: Flati
authors.forename: S
authors.initials: S
authors.lastname: Martinotti
authors.forename: A
authors.initials: A
authors.lastname: Pompilio
authors.forename: A
authors.initials: A
authors.lastname: Gambi
authors.forename: R
authors.initials: R
authors.lastname: Orru
authors.forename: I
authors.initials: I
authors.lastname: Robuffo
authors.forename: E
authors.initials: E
authors.lastname: Toniato
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D018441:Biofilms; D001709:Biotechnology; D005285:Fermentation; D009067:Mouthwashes / Q000494:pharmacology; D010510:Periodontal Diseases / Q000188:drug therapy; D011135:Polysaccharides, Bacterial / Q000378:metabolism*; D013295:Streptococcus mutans / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D009067:Mouthwashes; D011135:Polysaccharides, Bacterial