title: Urinary tract infections following renal transplantation: a single-center experience.
abstract: Urinary tract infection (UTI) is the most frequent infectious complication among renal transplant recipients and a frequent cause of bacteremia, sepsis and acute graft failure. To evaluate the incidence, risk factors, type of pathogens and long-term effect of UTIs on graft and patient survivals in our center, we performed a retrospective cohort study reviewing the medical records of patients who received a renal transplant at our center from June 1986 to December 2009, excluding patients who lost their grafts in the first month due to arterial or veins thrombosis and acute antibody-mediated rejection. We studied 393 kidney-transplanted recipients; at least one UTI occurred in 221 (53.69%) patients during the follow-up period. The most frequent pathogens isolated in urine culture were Escherichia coli (n = 39, 18.4%) and Klebsiella pneumonia (n = 31, 14.6%). When patients with UTIs were compared with those without UTIs, female gender and use of mycophenolate mofetil or azathioprine seemed to be risk factors for UTIs on univariate analysis. However, female gender was the only independent risk factor on multivariate analysis RR = 1.964 (1.202-3.207), P = 0.007. This study confirmed that UTIs remain a major problem in renal transplant recipients, and female gender was the only independent risk factor.
authors.affiliation: Research Laboratory of Immunology-LR03SP01, Charles Nicoles Hospital, Tunis, Tunisia. bksousou2007@yahoo.fr
authors.forename: Samia
authors.initials: S
authors.lastname: Barbouch
authors.forename: Mejda
authors.initials: M
authors.lastname: Cherif
authors.forename: Mondher
authors.initials: M
authors.lastname: Ounissi
authors.forename: Cyrine
authors.initials: C
authors.lastname: Karoui
authors.forename: Sonia
authors.initials: S
authors.lastname: Mzoughi
authors.forename: Fethi Ben
authors.initials: FB
authors.lastname: Hamida
authors.forename: Ezeddine
authors.initials: E
authors.lastname: Abderrahim
authors.forename: Abdellatif
authors.initials: A
authors.lastname: Bozouita
authors.forename: Taiebben
authors.initials: T
authors.lastname: Abdalla
authors.forename: Adel
authors.initials: A
authors.lastname: Kheder
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000009:adverse effects; D016009:Chi-Square Distribution; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D014416:Tunisia / Q000453:epidemiology; D014552:Urinary Tract Infections / Q000453:epidemiology* / Q000382:microbiology; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D001379:Azathioprine