title: A prospective study of the effects of the DRD2/ANKK1 TaqIA polymorphism and impulsivity on smoking initiation.
abstract: This study tested whether DRD2/ANKK1 TaqIA genotype predicted smoking initiation and subsequent use, and effects were mediated by sensation seeking and negative urgency. Between 2009 and 2012, college never smokers (n = 387) completed six assessments over 15 months; those who reported smoking were classified as initiators. Logistic regression indicated that the A1 allele was associated with initiation (p = .003). This effect was partially mediated by sensation seeking and negative urgency. Effects were stronger in Asian Americans. Findings have implications for improving prevention by including elements focused on urges to seek positive or negative reinforcement. Limitations and future directions are discussed.
authors.affiliation: Department of Psychiatry, University of California, San Diego, San Diego, California 92161, USA. nmdoran@ucsd.edu
authors.forename: Neal
authors.initials: N
authors.lastname: Doran
authors.forename: C Amanda
authors.initials: CA
authors.lastname: Schweizer
authors.forename: Mark G
authors.initials: MG
authors.lastname: Myers
authors.forename: Tiffany A
authors.initials: TA
authors.lastname: Greenwood
mesh_terms: D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D007175:Impulsive Behavior / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D044469:Racial Groups / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012309:Risk-Taking; D012907:Smoking / Q000235:genetics* / Q000523:psychology
chemical_list: D017448:Receptors, Dopamine D2; C489948:ANKK1 protein, human; D017346:Protein Serine-Threonine Kinases