title: Estrous cycle variation in anxiolytic-like effects of topiramate in Wistar rats in two animal models of anxiety-like behavior.
abstract: The anxiolytic-like effects of topiramate were assessed during several estrous cycle phases in Wistar rats tested in two animal models of anxiety-like behavior. In a conflict operant test, during proestrus, diazepam (1.3, 2.0mg/kg; P<0.05) or topiramate (20.0, 30.0mg/kg; P<0.05) increased the number of immediately punished responses. During metestrus-diestrus only the highest doses of diazepam (2.0mg/kg, P<0.05) or topiramate (30.0mg/kg, P<0.05) increased the number of immediately punished reinforcers. Similar results were obtained in the elevated plus-maze test: during proestrus, diazepam (1.3, 2.0mg/kg; P<0.05) or topiramate (20.0, 30.0mg/kg; P<0.05) produced anxiolytic-like actions. During metestrus-diestrus only the highest doses of diazepam (2.0mg/kg, P<0.05) or topiramate (30.0mg/kg, P<0.05) produced anxiolytic-like actions. Neither diazepam nor topiramate nor estrous cycle phases significantly modified the number of closed arm entries in the elevated plus-maze test. It is concluded that the response to neuromodulatory drugs for anxiety-like behavior varied according to the estrous cycle phases.
authors.affiliation: Laboratorio de Psicobiología y Etología, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, Mexico. mimolis@hotmail.com
authors.forename: Miguel
authors.initials: M
authors.lastname: Molina-Hernández
authors.forename: N Patricia
authors.initials: NP
authors.lastname: Téllez-Alcántara
authors.forename: Jorge I
authors.initials: JI
authors.lastname: Olivera-López
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Jaramillo
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy* / Q000503:physiopathology; D003216:Conditioning, Operant / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D030762:Estrous Cycle / Q000187:drug effects*; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D018782:Maze Learning / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D000077236:Topiramate
chemical_list: D014151:Anti-Anxiety Agents; D000077236:Topiramate; D005632:Fructose; D003975:Diazepam