title: Cytotoxic bioactivity of some phenylpropanoic acid derivatives.
abstract: In this study, we synthesized a series of phenylpropanoic acid derivatives based on modifications at four selected points of the molecular scaffold. The in vitro antiproliferative activities of the compounds were examined in representative human solid tumor cell lines. A SAR was established pointing out the relevance of the substituents. The best activity profiles were obtained for the derivatives bearing more lipophilic esters (GI50 3.1-21 microM).
authors.affiliation: INTEQUI-CONICET, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera -5700 San Luis, Argentina.
authors.forename: Guillermo F
authors.initials: GF
authors.lastname: Reta
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Tonn
authors.forename: Carla
authors.initials: C
authors.lastname: Ríos-Luci
authors.forename: Leticia G
authors.initials: LG
authors.lastname: León
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pérez-Roth
authors.forename: José M
authors.initials: JM
authors.lastname: Padrón
authors.forename: Osvaldo J
authors.initials: OJ
authors.lastname: Donadel
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010666:Phenylpropionates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D010666:Phenylpropionates