title: A prospective, randomized clinical trial comparing plasmakinetic resection of the prostate with holmium laser enucleation of the prostate based on a 2-year followup.
abstract: OBJECTIVE
  We compared plasmakinetic resection with holmium laser enucleation of the prostate for the treatment of benign prostatic hyperplasia by analyzing 2-year followup data from a prospective randomized clinical trial.
  
  
  METHODS
  A total of 280 patients were randomly treated with plasmakinetic resection or holmium laser enucleation of the prostate. Perioperative and postoperative outcome data were obtained during a 2-year followup.
  
  
  RESULTS
  No significant differences between the 2 surgical groups were observed in the preoperative data. Both groups displayed significant improvements after surgery. However, we identified no significant differences between the 2 groups in the 2-year followup data for I-PSS (International Prostate Symptom Score), quality of life scores or maximum flow rate values. Patients in the holmium laser enucleation group displayed a lower risk of hemorrhage, shorter bladder irrigation and catheter times, and shorter hospital stays. A larger amount of prostate tissue was retrieved in the holmium laser enucleation group, but the operation time was longer for this group than for the plasmakinetic resection group.
  
  
  CONCLUSIONS
  Plasmakinetic resection and holmium laser enucleation of the prostate are effective and safe treatments for benign prostatic hyperplasia. Holmium laser enucleation of the prostate can be applied to prostates of all sizes, and involves less risk of hemorrhage, decreased bladder irrigation and catheter times, as well as reduced hospital stay. Thus, we believe holmium laser enucleation of the prostate should be proposed as a potential new gold standard surgical therapy instead of transurethral resection of the prostate for patients with benign prostatic hyperplasia.
authors.affiliation: Department of Urology and Andrology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Chen
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Yu-Bing
authors.initials: YB
authors.lastname: Peng
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Ma
authors.forename: Da-Chao
authors.initials: DC
authors.lastname: Zheng
authors.forename: Zhi-Kang
authors.initials: ZK
authors.lastname: Cai
authors.forename: Wen-Ji
authors.initials: WJ
authors.lastname: Li
authors.forename: Liang-Hong
authors.initials: LH
authors.lastname: Ma
mesh_terms: D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000601:surgery*; D016037:Single-Blind Method; D013997:Time Factors; D020728:Transurethral Resection of Prostate / Q000379:methods*