title: Enhanced separation of Compound Xueshuantong capsule using functionalized carbon nanotubes with cationic surfactant solutions in MEEKC.
abstract: A novel additive of multi-walled carbon nanotubes (MWNTs) dispersed with cationic surfactants or mixed cationic/anionic surfactants was used for MEEKC separation of eight phenolic compounds, four glycosides, and one phenanthraquinone. In this context, several parameters affecting MEEKC separation were studied, including the dispersion agents of MWNTs, MWNTs content, oil type, SDS concentration, and the type and concentration of cosurfactant. Compared with conventional MEEKC, the addition of all types of MWNTs dispersions using single or mixed cationic surfactant solutions in running buffers was especially useful for improving the separation of solutes tested, as they influenced the partitioning between the oil droplets and aqueous phase due to the exceptional electrical properties and large surface areas of MWNTs. Use of cationic surfactant-coated MWNTs (6.4 μg/mL) as the additive in a microemulsion buffer (0.5% octanol, 2.8% SDS, 5.8% isopropanol, and 5 mM borate buffer) yielded complete resolution of 13 analytes. The proposed method has been successfully applied for the detection and quantification of the studied compounds in a complex matrix sample (Compound Xueshuantong capsule).
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Jue
authors.initials: J
authors.lastname: Chen
authors.forename: Ting
authors.initials: T
authors.lastname: Tan
authors.forename: Han-Bin
authors.initials: HB
authors.lastname: Dai
mesh_terms: D019840:2-Propanol; D002214:Capsules / Q000737:chemistry; D002412:Cations; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification; D015203:Reproducibility of Results; D012967:Sodium Dodecyl Sulfate; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D002214:Capsules; D002412:Cations; D002934:Cinnamates; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D006027:Glycosides; D037742:Nanotubes, Carbon; C519374:Panax notoginseng extract; D010636:Phenols; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D019840:2-Propanol