title: [Inhibiting contractility without necrosis: would it be helpful for hypertrophic cardiomyopathy? Experimental model of intramyocardial botulinum toxin and wortmannin].
abstract: The purpose of this paper is to introduce a new idea: local inhibition of contractility without necrosis. It's potential usefulness in hypertrophic cardiomyopathy treatment is discussed and 2 pharmacological models, administrating botulinum toxin and wortmannin directly in the myocardium are disclosed.
authors.affiliation: Departamento de Ecocardiografía, Instituto Nacional de Cardiología Ignacio Chávez, México D.F., México. roldanjavo@yahoo.com
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Roldán-Gómez
authors.forename: Natalia
authors.initials: N
authors.lastname: Pavón-Martínez
authors.forename: Faustino
authors.initials: F
authors.lastname: Gálvez-Pérez
authors.forename: Jesús
authors.initials: J
authors.lastname: Vargas-Barrón
mesh_terms: D000730:Androstadienes / Q000008:administration & dosage* / Q000494:pharmacology; D001905:Botulinum Toxins / Q000008:administration & dosage* / Q000494:pharmacology; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy*; D015552:Injections, Intralesional; D008962:Models, Theoretical; D009200:Myocardial Contraction / Q000187:drug effects; D009336:Necrosis / Q000517:prevention & control; D000077191:Wortmannin
chemical_list: D000730:Androstadienes; D001905:Botulinum Toxins; D000077191:Wortmannin