title: Demographic inference reveals African and European admixture in the North American Drosophila melanogaster population.
abstract: Drosophila melanogaster spread from sub-Saharan Africa to the rest of the world colonizing new environments. Here, we modeled the joint demography of African (Zimbabwe), European (The Netherlands), and North American (North Carolina) populations using an approximate Bayesian computation (ABC) approach. By testing different models (including scenarios with continuous migration), we found that admixture between Africa and Europe most likely generated the North American population, with an estimated proportion of African ancestry of 15%. We also revisited the demography of the ancestral population (Africa) and found-in contrast to previous work-that a bottleneck fits the history of the population of Zimbabwe better than expansion. Finally, we compared the site-frequency spectrum of the ancestral population to analytical predictions under the estimated bottleneck model.
authors.affiliation: Evolutionary Biology, University of Munich, 82152 Planegg-Martinsried, Germany. duchen@bio.lmu.de
authors.forename: Pablo
authors.initials: P
authors.lastname: Duchen
authors.forename: Daniel
authors.initials: D
authors.lastname: Zivkovic
authors.forename: Stephan
authors.initials: S
authors.lastname: Hutter
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Stephan
authors.forename: Stefan
authors.initials: S
authors.lastname: Laurent
mesh_terms: D000349:Africa; D000818:Animals; D001499:Bayes Theorem; D003198:Computer Simulation; D003433:Crosses, Genetic; D003710:Demography; D004331:Drosophila melanogaster / Q000235:genetics*; D005060:Europe; D005828:Genetics, Population; D008957:Models, Genetic; D009656:North America; D020641:Polymorphism, Single Nucleotide