title: Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol.
abstract: In the present study, the in vitro cytotoxic effects of six semi-synthetic derivatives of elatol (1) and isoobtusol (2) were investigated. Chemical modifications were performed on the hydroxyl groups aiming to get derivatives of different polarity, namely the hemisuccinate, carbamate and sulfamate. The structural elucidation of the new derivatives was based on detailed NMR and MS spectroscopic analyses. The in vitro cytotoxicity of compounds 1 to 8 was evaluated against A459 and RD tumor cell lines with CC₅₀ values ranging from 4.93 to 41.53 µM. These results suggest that the structural modifications performed on both compounds could be considered a good strategy to obtain more active derivatives.
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-970, Brazil.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Lang
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-970, Brazil.
authors.forename: Izabella T
authors.initials: IT
authors.lastname: Silva
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-970, Brazil.
authors.forename: Lara A
authors.initials: LA
authors.lastname: Zimmermann
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-970, Brazil.
authors.forename: Cíntia
authors.initials: C
authors.lastname: Lhullier
authors.affiliation: Department of Organic Chemistry, University of Buenos Aires, Buenos Aires, C1428EGA, Argentina.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Mañalich Arana
authors.affiliation: Department of Organic Chemistry, University of Buenos Aires, Buenos Aires, C1428EGA, Argentina.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Palermo
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-970, Brazil.
authors.forename: Miriam
authors.initials: M
authors.lastname: Falkenberg
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-970, Brazil.
authors.forename: Cláudia M O
authors.initials: CMO
authors.lastname: Simões
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-970, Brazil.
authors.forename: Eloir P
authors.initials: EP
authors.lastname: Schenkel
authors.affiliation: Department of Organic Chemistry, University of Buenos Aires, Buenos Aires, C1428EGA, Argentina.
authors.forename: Fernando J
authors.initials: FJ
authors.lastname: Durán
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D044722:Laurencia / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D013141:Spiro Compounds; C485576:elatol; C485577:isoobtusol