title: [Effect of a new triazinoindole derivative on the functional state of CNS in animals under normoxia and hypoxia conditions].
abstract: The influence of the new triazinoindole derivative encoded VM-606 on the individual behavior of rats in the open-field and elevated-plus-maze tests has been studied under normal conditions and after exposure to hypoxia with hypercapnia. It is established that VM-606 at a dose of 50 mg/kg under normoxia conditions reduces emotional anxiety, orientation-investigation activity, and mobility factor, while under hypoxic conditions this drug reduces the severity of behavioral changes in test animals. The experiments on mice showed that the compound studied potentiates the hypnotic effect of hexenal. It is suggested that VM-606 exhibits psychosedative and stress-protector properties, which play a certain role in its antihypoxic effect.
authors.forename: V E
authors.initials: VE
authors.lastname: Novikov
authors.forename: V V
authors.initials: VV
authors.lastname: Dikmanov
authors.forename: V V
authors.initials: VV
authors.lastname: Marysheva
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004357:Drug Synergism; D006591:Hexobarbital / Q000819:agonists / Q000494:pharmacology; D006935:Hypercapnia / Q000503:physiopathology; D006993:Hypnotics and Sedatives / Q000819:agonists / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D007211:Indoles / Q000819:agonists / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D014227:Triazines / Q000819:agonists / Q000494:pharmacology*
chemical_list: D006993:Hypnotics and Sedatives; D007211:Indoles; D014227:Triazines; D006591:Hexobarbital