title: Selecting SNPs for pharmacogenomic association study.
abstract: SNP genotyping device is an essential tool in the upcoming era ofpersonal genome and personalised medicine. Human genome has more than 10 million SNPs whereas conventional SNP genotyping device can only hold 1 million SNPs. Thus, intelligent SNP contents selection is required to maximise the value of SNP genotyping device. Here, we developed a new selection algorithm and applied this method to design genotyping contents for cancerand pharmacogenomic association study. This approach significantly increased the product value when compared with contents of competitive SNP genotyping product.
authors.affiliation: Interdisciplinary Program in Bioinformatics, Seoul National University, Gwanak-gu, Seoul 151-742, Korea. taejin.ahn@samsung.com
authors.forename: Tae Jin
authors.initials: TJ
authors.lastname: Ahn
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Park
authors.forename: Dae-Soon
authors.initials: DS
authors.lastname: Son
authors.forename: Nam
authors.initials: N
authors.lastname: Huh
authors.forename: Sohee
authors.initials: S
authors.lastname: Oh
authors.forename: Taejung
authors.initials: T
authors.lastname: Bae
authors.forename: Jung-Sun
authors.initials: JS
authors.lastname: Park
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Kyoohyoung
authors.initials: K
authors.lastname: Rho
authors.forename: Sunghoon
authors.initials: S
authors.lastname: Kim
authors.forename: Taesung
authors.initials: T
authors.lastname: Park
authors.forename: Kyusang
authors.initials: K
authors.lastname: Lee
mesh_terms: D000465:Algorithms; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D010597:Pharmacogenetics / Q000379:methods*; D020641:Polymorphism, Single Nucleotide