title: SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α.
abstract: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) is a master regulator of mitochondrial biogenesis in response to changes in the cellular environment, physiological or pathological status of mammals. PGC-1α is known to be modified by SUMO (Small Ubiquitin-like Modifier). However, it is not known whether SUMOylation could affect the function of PGC-1α in mitochondrial biogenesis and that how PGC-1α SUMOylation is regulated. In this study, we have identified the role of Sentrin/SUMO-specific protease 1 (SENP1) as a specific SUMO protease to regulate SUMOylation status of PGC-1α. More importantly, we have also found that SENP1 promotes PGC-1α transcription activity, which is essential for the expression of mitochondrial genes and subsequently mitochondrial biogenesis. Thus, we reveal that the SUMOylation of PGC-1α controlled by SENP1 plays an important role in mitochondrial biogenesis and function.
authors.affiliation: Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Cai
authors.forename: Tingting
authors.initials: T
authors.lastname: Yu
authors.forename: Chao
authors.initials: C
authors.lastname: Huang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Xia
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Liu
authors.forename: Jianmin
authors.initials: J
authors.lastname: Gu
authors.forename: Song
authors.initials: S
authors.lastname: Xue
authors.forename: Edward T H
authors.initials: ET
authors.lastname: Yeh
authors.forename: Jinke
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000818:Animals; D003546:Cysteine Endopeptidases; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism*; D057809:HEK293 Cells; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D063269:Mitochondrial Turnover; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D058207:Sumoylation; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors
chemical_list: D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; C501974:Senp1 protein, mouse