title: Unifying the genomics-based classes of cancer fusion gene partners: large cancer fusion genes are evolutionarily conserved.
abstract: BACKGROUND
  Genes that fuse to cause cancer have been studied to determine molecular bases for proliferation, to develop diagnostic tools, and as targets for drugs. To facilitate identification of additional, cancer fusion genes, following observation of a chromosomal translocation, we have characterized the genomic features of the fusion gene partners. Previous work indicated that cancer fusion gene partners, are either large or evolutionarily conserved in comparison to the neighboring genes in the region of a chromosomal translocation. These results raised the question of whether large cancer fusion gene partners were also evolutionarily conserved.
  
  
  RESULTS
  We developed two methods for quantifying evolutionary conservation values, allowing the conclusion that both large and small cancer fusion gene partners are more evolutionarily conserved than their neighbors. Additionally, we determined that cancer fusion gene partners have more 3' untranslated region secondary structures than do their neighbors.
  
  
  CONCLUSIONS
  Coupled with previous algorithms, with or without transcriptome approaches, we expect these results to assist in the rapid and efficient use of chromosomal translocations to identify cancer fusion genes. The above parameters for any gene of interest can be accessed at www.cancerfusiongenes.com.
authors.affiliation: Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Bd., MDC7, Tampa, Florida 33612, USA.
authors.forename: Libia M
authors.initials: LM
authors.lastname: Pava
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Morton
authors.forename: Ren
authors.initials: R
authors.lastname: Chen
authors.forename: George
authors.initials: G
authors.lastname: Blanck
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000465:Algorithms; D005075:Biological Evolution; D049109:Cell Proliferation; D052138:Genes, Neoplasm; D023281:Genomics / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; D015514:Oncogene Proteins, Fusion