title: Conflict of interest: will it ever end?
abstract: Despite the inclusion of investigator-industry pecuniary and non-pecuniary associations in published clinical trials, the benefit of such disclosures may be limited. Two recent pivotal phase III drug studies that raised conflict of interest issues are discussed. It is recommended that in the future, a firewall should be erected between industry and investigators.
authors.affiliation: Department of Nephrology, John Hunter Hospital, Newcastle, New South Wales, Australia. shane.carney@hnehealth.nsw.gov.au
authors.forename: S L
authors.initials: SL
authors.lastname: Carney
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000517:prevention & control; D026661:Clinical Trials Data Monitoring Committees / Q000941:ethics; D002986:Clinical Trials as Topic / Q000191:economics / Q000941:ethics*; D017326:Clinical Trials, Phase III as Topic / Q000191:economics / Q000941:ethics; D016265:Conflict of Interest; D004345:Drug Industry / Q000941:ethics; D057239:Early Termination of Clinical Trials; D005464:Fluorobenzenes / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D015201:Meta-Analysis as Topic; D009042:Motivation; D015337:Multicenter Studies as Topic / Q000191:economics / Q000941:ethics; D010506:Periodicals as Topic / Q000592:standards; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use; D015203:Reproducibility of Results; D012109:Research Support as Topic / Q000941:ethics*; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use; D000077486:Ticagrelor; D014342:Truth Disclosure / Q000941:ethics
chemical_list: D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium; D000077486:Ticagrelor; D000241:Adenosine