title: Elevated coagulation factor VIII plasma activity in a patient with lymphangiosarcoma.
abstract: A 72-year-old woman was referred to our hospital for palliative care. Fifteen years earlier, she had undergone total hysterectomy and radiotherapy for cervical cancer. One year before her referral, she visited a hospital due to a gait disturbance and was diagnosed with lymphangiosarcoma. The level of coagulation factor VIII plasma activity was >201% (normal range: 62-145%) and the immunohistochemical results were positive for factor VIII-related antigen in a tumor specimen. To the best of our knowledge, this is the first report of high coagulation factor VIII plasma activity in a patient with lymphangiosarcoma.
authors.affiliation: Department of General Internal Medicine 4, Kawasaki Medical School, Japan. hiromichi.ya@gmail.com
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Yamane
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Ochi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tabayashi
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yamagishi
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Monobe
authors.forename: Takehiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Eisei
authors.initials: E
authors.lastname: Kondoh
authors.forename: Nagio
authors.initials: N
authors.lastname: Takigawa
mesh_terms: D000368:Aged; D005169:Factor VIII / Q000378:metabolism*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008204:Lymphangiosarcoma / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D008209:Lymphedema / Q000150:complications; D013848:Thigh; D002583:Uterine Cervical Neoplasms / Q000150:complications; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D014841:von Willebrand Factor; D005169:Factor VIII