title: [Inductively coupled plasma mass spectrometry for the simultaneous determination of thirty metals and metalloids elements in blood samples].
abstract: OBJECTIVE
  To establish an inductively coupled plasma mass spectrometry(ICP-MS) method for determination of 30 trace elements including As, Ba, Be, Bi, Ni, Cd, Co, Cr, Cs, Cu, Ga, Mn, Pb, Sr, Tl, V, Ge, Mo, Nb, Ti, W, Te, Se, Zr, In, Sb, Hg, Ce, La, and Sm in human blood.
  
  
  METHODS
  The blood samples were analyzed by ICP-MS after diluted 1/10 with 0.01% Triton-X-100 and 0.5% nitric acid solution. Y, Rh and Lu were selected as internal standard in order to correct the matrix interference of Cr, As, Se, and Hg by a hex pole-based collision-reaction cell. Other elements were determined with standard method. The limits of detection, precision and accuracy of the method were evaluated. The accuracy was validated by the determination of the whole blood reference material.
  
  
  RESULTS
  All the 30 trace elements have good linearity in their determination range, with the correlation coefficient > 0.9999. The limits of detection of the 30 trace elements were in the range of 1.19 - 2.15 µg/L and the intra-precision and inter-precision (relative standard deviation, RSD) were less than 14.3% (except Hg RSD < 21.2%, and Ni RSD < 15.4%). The spiked recovery for all elements fell within 59.3% - 119.2%. Among the 13 whole blood reference materials, V, Cr, Mn, Co, Ni, Cu, As, Se, Cd, Te, and Pb (1.45, 1.19, 18.40, 0.18, 1.57, 591.00, 2.97, 61.00, 0.35, 1.86, and 9.70 µg/L respectively) fell within the acceptable range and the detection results of Hg (0.59 µg/L) and Mo (1.59 µg/L) were slightly beyond the range.
  
  
  CONCLUSIONS
  This method was simple, fast and effective. It can be used to monitor the multi-elementary concentration in human blood.
authors.affiliation: National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Chun-guang
authors.initials: CG
authors.lastname: Ding
authors.forename: Chun
authors.initials: C
authors.lastname: Zhu
authors.forename: De-ye
authors.initials: DY
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Dong
authors.forename: Ai-hua
authors.initials: AH
authors.lastname: Zhang
authors.forename: Ya-juan
authors.initials: YJ
authors.lastname: Pan
authors.forename: Hui-fang
authors.initials: HF
authors.lastname: Yan
mesh_terms: D006801:Humans; D057230:Limit of Detection; D013058:Mass Spectrometry / Q000379:methods*; D058955:Metalloids / Q000097:blood*; D008670:Metals / Q000097:blood*; D014131:Trace Elements / Q000097:blood
chemical_list: D058955:Metalloids; D008670:Metals; D014131:Trace Elements