title: Rational design of Hg2+ controlled streptavidin-binding aptamer.
abstract: Through substituting two canonical base pairs of a streptavidin-binding aptamer with T-T mismatched base pairs, a new aptamer was constructed. Its binding ability could be controlled by Hg(2+) through the formation of T-Hg-T metal-base pairs.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Hongcheng
authors.initials: H
authors.lastname: Mei
authors.forename: Tao
authors.initials: T
authors.lastname: Bing
authors.forename: Cui
authors.initials: C
authors.lastname: Qi
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Liu
authors.forename: Tianjun
authors.initials: T
authors.lastname: Chang
authors.forename: Jingli
authors.initials: J
authors.lastname: Yan
authors.forename: Dihua
authors.initials: D
authors.lastname: Shangguan
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000378:metabolism*; D020137:Base Pair Mismatch; D006427:Hemin / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D008628:Mercury / Q000737:chemistry*; D010544:Peroxidases / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D019809:Streptavidin / Q000378:metabolism*; D013936:Thymidine / Q000737:chemistry
chemical_list: D052157:Aptamers, Nucleotide; D007477:Ions; D006427:Hemin; D019809:Streptavidin; D010544:Peroxidases; D008628:Mercury; D013936:Thymidine