title: Combination of multichannel single-voxel MRS signals using generalized least squares.
abstract: OBJECTIVE
  To propose using the generalized least square (GLS) algorithm for combining multichannel single-voxel magnetic resonance spectroscopy (MRS) signals.
  
  
  METHODS
  Phantom and in vivo brain MRS experiments on a 7 T scanner equipped with a 32-channel receiver coil, as well as Monte Carlo simulations, were performed to compare the coefficient of variation (CV) of the GLS method with those of two recently reported spectral combination methods.
  
  
  RESULTS
  Compared to the two existing methods, the GLS method significantly reduced CV values for the simulation, phantom, and in vivo experiments.
  
  
  CONCLUSIONS
  The GLS method can lead to improved precision of peak quantification.
authors.affiliation: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. li.an@nih.gov
authors.forename: Li
authors.initials: L
authors.lastname: An
authors.forename: Jan
authors.initials: J
authors.lastname: Willem van der Veen
authors.forename: Shizhe
authors.initials: S
authors.lastname: Li
authors.forename: David M
authors.initials: DM
authors.lastname: Thomasson
authors.forename: Jun
authors.initials: J
authors.lastname: Shen
mesh_terms: D000465:Algorithms; D001923:Brain Chemistry; D003627:Data Interpretation, Statistical; D006801:Humans; D016018:Least-Squares Analysis; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity