title: An analysis of the relationship between ankle-brachial index and estimated glomerular filtration rate in type 2 diabetes.
abstract: We investigated the relationship between peripheral arterial disease (PAD) and renal function in patients with type 2 diabetes mellitus (T2DM). We enrolled 2057 hospitalized patients with T2DM and measured kidney function and ankle-brachial index (ABI). The estimated glomerular filtration rate (eGFR) was derived using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and ABI was grouped as low (<0.9), low-normal (0.9-1.09), normal (1.1-1.3), and high (>1.3). Logistic regression was used to evaluate the associations of eGFR with ABI. Generally speaking, the ABI was negatively correlated with systolic blood pressure, fasting C-peptide, total cholesterol, and low-density lipoprotein cholesterol while positively correlated with body mass index (P < .05 to <.01). Only a low ABI was positively correlated with eGFR (P < .01). In addition to the association of the ABI with cardiovascular events, stroke, and PAD, ABI may also predict the change in renal function in patients with T2DM.
authors.affiliation: Department of Endocrinology, Nanjing Medical University Affiliated Nanjing Hospital, Nanjing, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Jin
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Ma
authors.forename: Yun
authors.initials: Y
authors.lastname: Shen
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
authors.forename: Xiao-fei
authors.initials: XF
authors.lastname: Su
authors.forename: Ying-yue
authors.initials: YY
authors.lastname: Chen
authors.forename: Shao-kang
authors.initials: SK
authors.lastname: Qi
authors.forename: Jin-dan
authors.initials: JD
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000503:physiopathology*; D051436:Renal Insufficiency, Chronic