title: [Expression of serum sICAM-1 in patients with primary hepatocellular carcinoma and its relationship with liver fibrosis].
abstract: OBJECTIVE
  To explore the clinical value of serum soluble intercellular adhesion molecule-1 (sICAM-1) in patients with primary hepatocellular carcinoma (PHC) and its relationship with liver fibrosis.
  
  
  METHODS
  The serun sICAM-1, PC III, IV-C, LN and HA level of 45 cases of patients with PHC, 30 cases of benign tumor and 35 cases of healthy people were determined by ELISA, the relationship between sICAM-1 and liver fibrosis was analyzed.
  
  
  RESULTS
  The serum sICAM-1, PC III, IV-C, LN and HA levels of the PHC group were significantly higher than that of the benign tumor group and normal control group, compared the difference was significant (P<0.05); The serum markers was no significant difference between the benign tumor group and normal control group (P>0.05); The serum sICAM-1 was positively correlated with the PC III, IV-C, LN and HA (γ= 0.683, 0.575, 0.573 and 0.539, P<0.05).
  
  
  CONCLUSIONS
  Detection of serum sICAM-1 has important clinical significance for assessing the PHC patient's condition, early diagnosing and treating liver cancer.
authors.affiliation: Department of Oncology, No. 421 Hospital of PLA, Guangzhou, China. zhou_silang@163.com
authors.forename: Si-lang
authors.initials: SL
authors.lastname: Zhou
authors.forename: Yong-le
authors.initials: YL
authors.lastname: Chen
authors.forename: Xin-zhao
authors.initials: XZ
authors.lastname: Peng
authors.forename: Yong-xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Pei-zeng
authors.initials: PZ
authors.lastname: Xie
authors.forename: Long
authors.initials: L
authors.lastname: Ling
authors.forename: Xiao-wen
authors.initials: XW
authors.lastname: Chen
authors.forename: Kai-ming
authors.initials: KM
authors.lastname: Dai
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000473:pathology*; D024061:Collagen Type III / Q000097:blood; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood* / Q000473:pathology*; D008113:Liver Neoplasms / Q000097:blood* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D024061:Collagen Type III; D018799:Intercellular Adhesion Molecule-1