title: Efficient catalyst-free four-component synthesis of novel γ-aminoethers mediated by a Mannich type reaction.
abstract: Herein, it is provided an efficient and one-pot procedure for the synthesis of novel and diversely substituted γ-aminoethers in good yields through a four-component process by treatment of benzylamines with polyformaldehyde and activated alkenes in aliphatic alcohols acting both as solvent and as etherificant agents. Reactions proceeded via a Mannich-type reaction, where the formation of iminium ions and aminals was identified as the key intermediates to obtain the target products.
authors.affiliation: Research Group of Heterocyclic Compounds, Department of Chemistry, Universidad del Valle , A. A. 25360, Cali, Colombia.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Abonia
authors.forename: Juan
authors.initials: J
authors.lastname: Castillo
authors.forename: Braulio
authors.initials: B
authors.lastname: Insuasty
authors.forename: Jairo
authors.initials: J
authors.lastname: Quiroga
authors.forename: Manuel
authors.initials: M
authors.lastname: Nogueras
authors.forename: Justo
authors.initials: J
authors.lastname: Cobo
mesh_terms: D001596:Benzylamines / Q000737:chemistry*; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001596:Benzylamines; D004987:Ethers