title: Tumor angiogenesis and lymphangiogenesis: tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms.
abstract: Tumor angiogenesis and lymphangiogenesis are key features of tumor progression and metastasis. The role of tumor cells-derived factors in the promotion of associated angiogenesis and lymphangiogenesis is much studied and, no doubt, very important for the understanding of cancer progression. This review aims to present and discuss the work done on the pro-angiogenic and lymphangiogenic cellular interactions within the tumor microenvironment and the signaling pathways that regulate this crosstalk. Such multifactor studies are critical for the development of future therapeutic approaches for cancer because they take into account the complexities of cellular interactions within the tumor microenvironment.
authors.affiliation: Nucleus of Cellular and Tecidual Biology (NCTBio), Department of Oral Pathology, School of Dentistry, Federal University of Pelotas, Brazil.
authors.forename: Fausto Gueths
authors.initials: FG
authors.lastname: Gomes
authors.forename: Fernanda
authors.initials: F
authors.lastname: Nedel
authors.forename: Alessandro Menna
authors.initials: AM
authors.lastname: Alves
authors.forename: Jacques Eduardo
authors.initials: JE
authors.lastname: Nör
authors.forename: Sandra Beatriz Chaves
authors.initials: SB
authors.lastname: Tarquinio
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D004729:Endothelium, Lymphatic / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D042583:Lymphangiogenesis / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D009369:Neoplasms / Q000098:blood supply* / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*