title: [Lineage fate decisions in normal and regenerating liver].
abstract: The origin of hepatocytes and cholangiocytes in embryonic and adult liver, as well as the source of stellate and sinusoidal cells, have received much attention recently, due to the availability of biological tools enabling to trace the fate of cell lineages. A model is now proposed which defines the differentiation potential of hepatoblasts, ductal plate cells and adult progenitor cells, in normal conditions and in regenerating liver. The mesodermal origin of stellate and sinusoidal cells is also established.
authors.affiliation: Institut de Duve, Université catholique de Louvain, Bruxelles, Belgique. frederic.lemaigre@uclouvain.be
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lemaigre
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000032:analysis / Q000493:pharmacokinetics; D001652:Bile Ducts / Q000166:cytology* / Q000196:embryology; D019070:Cell Lineage; D004707:Endoderm / Q000166:cytology; D018507:Gene Expression Regulation, Developmental; D055166:Hepatic Stellate Cells / Q000166:cytology; D022781:Hepatocytes / Q000166:cytology*; D006706:Homeostasis; D008099:Liver / Q000196:embryology / Q000254:growth & development; D008115:Liver Regeneration / Q000502:physiology*; D008164:Luminescent Proteins / Q000032:analysis / Q000493:pharmacokinetics; D008648:Mesoderm / Q000166:cytology; D051379:Mice; D009024:Morphogenesis; D055758:SOX9 Transcription Factor / Q000502:physiology; D015027:Zebrafish
chemical_list: D001426:Bacterial Proteins; D008164:Luminescent Proteins; D055758:SOX9 Transcription Factor; C054562:yellow fluorescent protein, Bacteria