title: CXCR3 blockade: a novel anti-sepsis approach?
abstract: Blockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and inflammatory mediators that orchestrate sepsis syndrome, more detailed investigations will be required before a complete understanding of the mechanism(s) of CXCR3 blockade and its therapeutic potential are revealed.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Delano
authors.forename: Lyle L
authors.initials: LL
authors.lastname: Moldawer
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007074:Immunoglobulin G; D054367:Receptors, CXCR3 / Q000037:antagonists & inhibitors*; D018805:Sepsis / Q000188:drug therapy*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D054367:Receptors, CXCR3