title: Molecular pathways: regulation of metabolism by RB.
abstract: The discovery of the retinoblastoma (RB-1) gene as a tumor suppressor that is disrupted in a majority of human cancers either via direct or indirect genetic alterations has resulted in increased interest in its functions and downstream effectors. Although the canonical pathway that links this tumor suppressor to human cancers details its interaction with the E2F transcription factors and cell-cycle progression, recent studies have shown an essential role for RB-1 in the suppression of glycolytic and glutaminolytic metabolism. Characterization of the precise metabolic transporters and enzymes suppressed by the RB-E2F axis should enable the identification of small molecule antagonists that have selective and potent antitumor properties.
authors.affiliation: Department of Medicine, Molecular Targets Group, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA. bfclem01@louisville.edu
authors.forename: Brian F
authors.initials: BF
authors.lastname: Clem
authors.forename: Jason
authors.initials: J
authors.lastname: Chesney
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism; D005947:Glucose / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000235:genetics / Q000502:physiology*
chemical_list: D016160:Retinoblastoma Protein; D005973:Glutamine; D005947:Glucose