title: Mitochondrial dynamics in neurodegeneration.
abstract: It has been only 15 years since studies began on the molecular mechanisms underlying mitochondrial fission and fusion using simple model organisms such as Drosophila, yeast, and Caenorhabditis elegans. Beyond the primary functions of mitochondrial fission and fusion in controlling organelle shape, size, and number, it became clear that these dynamic processes are also critical to regulating cell death, mitophagy, and organelle distribution. Now, studies suggest that prominent changes occur in mitochondrial dynamics in a broad array of neurodegenerative diseases, and there is substantial evidence suggesting a key role in disease pathogenesis because neurons are among the most energy-consuming cell types and have a highly developed cell shape. Here, we review the recent findings on mitochondrial dynamics in neurodegeneration.
authors.affiliation: Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Kie
authors.initials: K
authors.lastname: Itoh
authors.forename: Ken
authors.initials: K
authors.lastname: Nakamura
authors.forename: Miho
authors.initials: M
authors.lastname: Iijima
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sesaki
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001692:Biological Transport; D016923:Cell Death; D034281:Dynamins; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000378:metabolism / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology*; D063154:Mitochondrial Dynamics; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D063306:Mitophagy; D009154:Mutation; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology; D029241:Optic Atrophy, Autosomal Dominant / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress
chemical_list: D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D020558:GTP Phosphohydrolases; C110768:DNM1L protein, human; D034281:Dynamins