title: [Effect of propofol and inhalation anesthesia on postoperative cognitive dysfunction in the elderly: a meta-analysis].
abstract: OBJECTIVE
  To compare the effects of propofol and inhalation anesthesia on the incidence of early postoperative cognitive dysfunction (POCD) in elderly patients undergoing noncardiac surgeries.
  
  
  METHODS
  PubMed, Cochrane Library, CBM, CNKI, Wanfang data and VIP Database (by October 2012) were searched for randomized controlled trials (RCTs) comparing propofol and inhalation anesthesia for their impact on the incidence of early POCD in elderly patients undergoing noncardiac surgeries. After data extraction and quality evaluation, Stata 12.0 software was used for statistical data analysis.
  
  
  RESULTS
  Thirteen RCTs, including 2 comparing propofol with xenon, 7 comparing propofol with sevoflurane, and 4 comparing propofol with isoflurane were obtained, involving a total of 753 patients. The odds ratio of early POCD incidence between patients with propofol anesthesia and those with xenon anesthesia, sevoflurane anesthesia, and isoflurane anesthesia were 1.62 (95% CI 0.81-3.23, P=0.533), 0.67 (95% CI 0.39-1.14, P=0.830), and 0.20 (95% CI 0.08-0.50, P=0.925), respectively. Overall, the odds ratio of early POCD incidence between propofol anesthesia and inhalation anesthesia was 0.68 (95% CI 0.47-0.98, P=0.189). Egger's test showed a publication bias of the RCTs retrieved (P=0.011).
  
  
  CONCLUSIONS
  Compared with inhalation anesthesia, propofol anesthesia is associated with a lower incidence of early POCD in elderly patients, but this conclusion needs to be further verified by more well-designed large-scale RCTs.
authors.affiliation: Department of Anesthesiology, Guangdong Academy of Medical Sciences, Guangzhou, China. dadibense@126.com
authors.forename: Dejiang
authors.initials: D
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Guodong
authors.initials: G
authors.lastname: Zhao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation; D003072:Cognition Disorders / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D011184:Postoperative Period; D015742:Propofol
chemical_list: D018685:Anesthetics, Inhalation; D015742:Propofol