title: The first ratiometric fluorescent probes for aminopeptidase N cell imaging.
abstract: In the current paper, three activity-based colorimetric and ratiometric fluorescent probes based on a naphthalimide fluorophore were well designed and synthesized, which can be recognized and hydrolyzed by aminopeptidase N (APN) at both the enzymatic and cellular level by following the fluorescent emission wavelength change from blue to green light. As a result, these molecules were successfully identified as the first ratiometric fluorescent probes for APN cell imaging.
authors.affiliation: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China.
authors.forename: Laizhong
authors.initials: L
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Zhao
authors.initials: Z
authors.lastname: Ma
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Lupei
authors.initials: L
authors.lastname: Du
authors.forename: Wenfang
authors.initials: W
authors.lastname: Xu
authors.forename: Hao
authors.initials: H
authors.lastname: Fang
authors.forename: Minyong
authors.initials: M
authors.lastname: Li
mesh_terms: D018826:CD13 Antigens / Q000378:metabolism*; D045744:Cell Line, Tumor; D003124:Colorimetry / Q000379:methods*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D018826:CD13 Antigens