title: Defining a prognostic molecular profile for ductal adenocarcinoma of the pancreas highlights known key signaling pathways.
abstract: There has been very little progress in improving outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) over the past few decades. High-throughput array profiling has made it possible to discover new assays to diagnose or prognose PDAC more accurately based on the genetic profile of an individual tumor. To improve patient survival, there is a need to extract the most practical data to define tumor subgroups and personalize anticancer therapy. In the evaluated study, a multiplatform, survival-based analysis of molecular changes was performed for PDAC to discover clinically useful biomarkers. A composite score predictive for survival was calculated for individual genes, taking into account the DNA copy-number and any regulation by miRNAs. Several genes involved in the PI3K/AKT and SRC signaling pathways were identified and further investigated.
authors.affiliation: Department of Surgery and Cancer, HPB Surgical Unit, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK. a.frampton@imperial.ac.uk
authors.forename: Adam E
authors.initials: AE
authors.lastname: Frampton
authors.forename: Jonathan
authors.initials: J
authors.lastname: Krell
authors.forename: Elisa
authors.initials: E
authors.lastname: Giovannetti
authors.forename: Daniel
authors.initials: D
authors.lastname: Krell
authors.forename: Justin
authors.initials: J
authors.lastname: Stebbing
authors.forename: Leandro
authors.initials: L
authors.lastname: Castellano
authors.forename: Long R
authors.initials: LR
authors.lastname: Jiao
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism; D011379:Prognosis; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D015398:Signal Transduction; D016019:Survival Analysis; D059467:Transcriptome
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt