title: A general organocatalytic approach toward the enantioselective total synthesis of indolizidine based alkaloids.
abstract: Four indolizidine based alkaloids (IBAs) have been synthesized in a highly enantioselective, straightforward, and flexible manner. As a key step our previously developed Brønsted acid catalyzed vinylogous Mannich reaction was employed which easily afforded gram amounts of an optically pure central intermediate which can be converted into a wide range of diversely substituted IBAs.
authors.affiliation: Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig.
authors.forename: Falko
authors.initials: F
authors.lastname: Abels
authors.forename: Chris
authors.initials: C
authors.lastname: Lindemann
authors.forename: Eva
authors.initials: E
authors.lastname: Koch
authors.forename: Christoph
authors.initials: C
authors.lastname: Schneider
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D054836:Indolizidines / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D054836:Indolizidines