title: Early bone healing around 2 different experimental, HA grit-blasted, and dual acid-etched titanium implant surfaces. A pilot study in rabbits.
abstract: OBJECTIVE
  To compare early bone healing around different experimental titanium implant surfaces and to evaluate the role of a calcium phosphate-coated implant surface because it relates to bone-implant contact (BIC).
  
  
  METHODS
  An experimental hydroxyapatite (HA) grit-blasted and dual acid-etched titanium surface (BAE-1) was compared to an experimental HA grit-blasted and dual acid-etched surface treated with nanometer-scale crystals of HA (BAE-2). Both experimental implant surfaces were implanted onto the tibias of 4 New Zealand white rabbits. The animals were killed at 1,6, 21, and 90 days after the implant surgery. Descriptive histology was performed at the healing responses of both implant surfaces. Quantitative morphology assessment provided measurements of BIC, number of bone multicellular units (BMUs), average penetration of BMUs, and maximum penetration of BMUs that were manually made using imaging computer software.
  
  
  RESULTS
  The overall BIC for the BAE-2 implant was higher than that for the BAE-1 implant at 21 days of healing. However, there was no significant difference at 90 days of healing.
  
  
  CONCLUSIONS
  It is concluded from this animal pilot study that the bioactive BAE-2 implant surface provided a better BIC with healthy bone remodeling at 21 days of healing.
authors.affiliation: Department of Oral Medicine, Infection and Immunity, School of Dental Medicine, Harvard University, Boston, MA, USA. luca_gobbato@hsdm.harvard.edu
authors.forename: Luca
authors.initials: L
authors.lastname: Gobbato
authors.forename: Emilio
authors.initials: E
authors.lastname: Arguello
authors.forename: Ignacio Sanz
authors.initials: IS
authors.lastname: Martin
authors.forename: Charles E
authors.initials: CE
authors.lastname: Hawley
authors.forename: Terrence J
authors.initials: TJ
authors.lastname: Griffin
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D000818:Animals; D001857:Bone Matrix / Q000473:pathology; D016723:Bone Remodeling / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003461:Crystallography; D045662:Dental Etching / Q000379:methods; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry*; D017267:Dental Prosthesis Design; D017886:Durapatite / Q000737:chemistry; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007368:Interferometry; D059630:Mesenchymal Stem Cells / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D010865:Pilot Projects; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D014945:Wound Healing / Q000502:physiology
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D003764:Dental Materials; D017886:Durapatite; D014025:Titanium