title: Interaural differences of distortion product otoacoustic emission amplitudes in patients with unilateral tinnitus.
abstract: OBJECTIVE
  We aimed to determine whether abnormalities in outer hair cell (OHC) function were related to tinnitus through interaural comparison of distortion product otoacoustic emissions (DPOAEs).
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Tertiary care university teaching hospital.
  
  
  METHODS
  Twenty-seven patients with unilateral tinnitus and pure-tone average of both ears ≤ 25 dB hearing loss (HL) at 500, 1000, 2000, and 4000 Hz were included.
  
  
  METHODS
  Pure-tone thresholds observed at 500 to 16,000 Hz and DPOAE amplitudes at f2 frequencies of 1001 to 6348 Hz were compared between the tinnitus ears and nontinnitus ears in patients with unilateral tinnitus.
  
  
  RESULTS
  The pure-tone averages (13 ± 6 dB HL) in the nontinnitus ears were similar to those (15 ± 6 dB HL) in the tinnitus ears. There were no differences in pure-tone averages at all frequencies tested. While the DPOAE amplitudes measured at f2 frequencies of 1001 to 3174 Hz in tinnitus ears were not different from those in the nontinnitus ears, the tinnitus ears showed significantly reduced DPOAE amplitudes when compared with the nontinnitus ears at frequencies of 4004 to 6348 Hz.
  
  
  CONCLUSIONS
  OHC dysfunction was correlated with tinnitus at high frequencies, and DPOAE amplitudes can provide additional information about cochlear dysfunction, which is complementary to pure-tone audiometry.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Joon Pyo
authors.initials: JP
authors.lastname: Park
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Lim
authors.forename: Byoung Soo
authors.initials: BS
authors.lastname: Shim
authors.forename: Tae Su
authors.initials: TS
authors.lastname: Kim
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Chung
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Yoon
authors.forename: Hong Ju
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001301:Audiometry, Pure-Tone; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006198:Hair Cells, Auditory / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous; D014012:Tinnitus / Q000503:physiopathology*