title: Facilitative effect of serotonin(1A) receptor agonists on cognition in patients with schizophrenia.
abstract: Disturbances of cognitive function are considered to largely affect the outcome in patients with schizophrenia. There is much attention to the role of psychotropic compounds acting on serotonin (5-HT) receptors in ameliorating cognitive deficits of the disease. Among the 5-HT receptor subtypes, the 5-HT(1A) receptor is attracting particular interests as a potential target for enhancing cognition, based on preclinical and clinical evidence. The neural network underlying the ability of 5-HT(1A) agonists to treat cognitive impairments of schizophrenia likely includes dopamine, glutamate, and gamma-aminobutyric acid neurons. Recent advances of electrophysiological measures, such as event-related potentials, have provided insights into facilitative effects on cognition of some atypical antipsychotic drugs or related compounds acting directly or indirectly on 5-HT(1A) receptors. These considerations are expected to promote the development of novel therapeutics for the betterment of functional outcome in people suffering from schizophrenia.
authors.affiliation: Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama, 930-0194 Japan. tomikisumiyoshi840@hotmail.com
authors.forename: T
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Higuchi
mesh_terms: D003071:Cognition / Q000187:drug effects*; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy*; D058825:Serotonin 5-HT1 Receptor Agonists / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D058825:Serotonin 5-HT1 Receptor Agonists