title: Neutrophils engraftment delay during tigecycline treatment in 2 bone marrow-transplanted patients.
abstract: BACKGROUND
  Tigecycline is the first available drug of glycylcycline family. Because of recent introduction, some of its adverse effects could be still unexplored.
  
  
  METHODS
  We report the cases of 2 boys who underwent an allogenic bone marrow transplantation for acute myeloid leukemia and were treated with tigecycline. Erythrocyte and platelet engraftment followed a normal course, but the neutrophil count remained low despite the increase in leukocyte count. After tigecycline interruption, the neutrophil count rapidly raised in both cases.
  
  
  CONCLUSIONS
  Neutropenia was suspected to be secondary to tigecycline exposure. In vitro experiments were performed, which suggested tigecycline influence on myeloid cells survival.
authors.affiliation: Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy. maximova@burlo.trieste.it
authors.forename: Natalia
authors.initials: N
authors.lastname: Maximova
authors.forename: Davide
authors.initials: D
authors.lastname: Zanon
authors.forename: Federico
authors.initials: F
authors.lastname: Verzegnassi
authors.forename: Marilena
authors.initials: M
authors.lastname: Granzotto
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006085:Graft Survival; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D007958:Leukocyte Count; D008297:Male; D008911:Minocycline / Q000009:adverse effects / Q000031:analogs & derivatives*; D022423:Myeloid Cells / Q000187:drug effects / Q000473:pathology*; D009503:Neutropenia / Q000139:chemically induced* / Q000628:therapy; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology*; D011379:Prognosis; D000078304:Tigecycline; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline