title: Spindle-cell variant of primary cutaneous follicle center lymphoma spreading to the hepatobiliary tree, mimicking Klatskin tumor.
abstract: Primary cutaneous follicle center lymphoma (pcFCL) is an indolent type of primary cutaneous B-cell lymphoma (pcBCL) rarely disseminating to other organs. PcBCL with spindle-cell morphology has been described as a rare variant of pcFCL but the prognosis data of this variant is sparse. We report a rare case of spindle-cell pcFCL with CD20(+), CD79a(+), CD3(+), Bcl-6(+), Mum-1(-) and CD10(-) tumor cells that infiltrated the hepatic hilum, mimicking a Klatskin tumor. On the basis of the sparse published data on spindle-cell morphology of pcBCL, this growth pattern should elicit awareness of an increased risk of systemic involvement in the otherwise indolent pcFCL.
authors.affiliation: Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Sima
authors.initials: S
authors.lastname: Rozati
authors.forename: Katrin
authors.initials: K
authors.lastname: Kerl
authors.forename: Werner
authors.initials: W
authors.lastname: Kempf
authors.forename: Marianne
authors.initials: M
authors.lastname: Tinguely
authors.forename: Dieter R
authors.initials: DR
authors.lastname: Zimmermann
authors.forename: Reinhard
authors.initials: R
authors.lastname: Dummer
authors.forename: Antonio
authors.initials: A
authors.lastname: Cozzio
mesh_terms: D001650:Bile Duct Neoplasms / Q000235:genetics / Q000556:secondary*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000235:genetics / Q000556:secondary*; D003937:Diagnosis, Differential; D006801:Humans; D018285:Klatskin Tumor / Q000235:genetics / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*