title: The distribution of apolipoprotein E gene polymorphism in Chinese civil aircrews, and a possible risk factor to their overweight and dyslipidemia is cumulative flight time.
abstract: BACKGROUND
  The prevalence of dyslipidemia and overweight is significantly higher in aircrews than that in general population. The purpose of the study was to examine the distribution of APOE gene polymorphism and the influence of which as well as occupational environment on dyslipidemia and overweight in Chinese civil aircrews.
  
  
  METHODS
  APOE gene polymorphism was investigated using PCR-RFLP, plasma lipid parameters were measured by standard enzymatic kits and personal information of the aircrews was collected through questionnaires.
  
  
  RESULTS
  The allele frequencies among aircrews were ε2: 17.0%, ε3: 80.9%, and ε4: 2.1%, APOE gene polymorphism was associated with significant differences in TC and LDL-C. E2 individuals had the lowest TC and LDL-C concentrations, and E4 participants had the highest levels (p<0.001). In addition, the TC and LDL-C concentrations, as well as BMI rose with the increasing cumulative flying hours (p<0.05). The further logistic regression analysis showed the significant associations of BMI and dyslipidemia (p<0.0001, OR=2.093), cumulative flight time and overweight (p<0.0001, OR=1.560).
  
  
  CONCLUSIONS
  The distribution of APOE alleles among aircrews was provided for the first time, which is not fully identical with that among general population. These data also suggested the cumulative flight time influenced dyslipidemia and overweight as an environmental contributor.
authors.affiliation: Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Yingjin
authors.initials: Y
authors.lastname: Feng
authors.forename: Weiru
authors.initials: W
authors.lastname: Chen
mesh_terms: D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D050171:Dyslipidemias / Q000235:genetics* / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000235:genetics* / Q000473:pathology; D050177:Overweight / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D014195:Travel
chemical_list: D001057:Apolipoproteins E