title: A new direction for gene looping.
abstract: Upon binding to a promoter, RNA polymerase II can synthesize either a coding mRNA or a divergently transcribed noncoding RNA. In a recent issue of Science, Tan-Wong et al. (2012) find that intragenic looping increases the proper orientation of RNA polymerase II, reducing the production of divergent noncoding transcripts.
authors.affiliation: Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
authors.forename: Carlo E
authors.initials: CE
authors.lastname: Randise-Hinchliff
authors.forename: Jason H
authors.initials: JH
authors.lastname: Brickner