title: Histopathological features of bisphosphonate-associated osteonecrosis: findings in patients treated with partial mandibulectomies.
abstract: The present study investigated the histopathologic and radiographic features of stage 3 bisphosphonate-associated osteonecrosis of the jaw (BAONJ) in patients who were treated with partial mandibulectomies. Bisphosphonates had been orally administered to 10 patients with osteoporosis and intravenously administered to 1 patient with metastatic carcinoma. On radiographic images, massive osteolysis and periosteal bone formations were conspicuous, and a thin mandibular cortical width was observed in 5 of 10 osteoporosis patients despite the previous use of bisphosphonate. Microscopically, the mandibulectomy specimens of the patients could be divided into 4 distinct layers. Although there were few differences in overall histologic features between BAONJ and chronic suppurative osteomyelitis, a notable number of osteoclasts were found detached from the bony trabeculae in BAONJ.
authors.affiliation: Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Young-Ah
authors.initials: YA
authors.lastname: Cho
authors.forename: Hye-Jung
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Jae-Il
authors.initials: JI
authors.lastname: Lee
authors.forename: Sam-Pyo
authors.initials: SP
authors.lastname: Hong
authors.forename: Seong-Doo
authors.initials: SD
authors.lastname: Hong
mesh_terms: D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008334:Mandible / Q000000981:diagnostic imaging / Q000601:surgery*; D008875:Middle Aged; D011862:Radiography, Panoramic