title: Neuroserpin upregulates in the early period of sustained spinal cord compression.
abstract: BACKGROUND
  Neuroserpin (NSP) is a neuroprotective factor in the situation of ischemia of a brain, such as stroke. However, it has never been reported in the spinal cord, which is part of the central nervous system (CNS).
  
  
  METHODS
  The expression of NSP was detected using Western blotting and neuron apoptosis detected by TUNEL staining following spinal cord ischemia caused by sustained compression in rats.
  
  
  RESULTS
  The results showed that NSP was upregulated in the injury area of spinal cord, accompanied with the activation of micorglia and tissue plasminogen activator (tPA), which suggested that NSP also plays a neuroprotective role in spinal cord compression since neuronal apoptosis appears when NSP returns to normal levels or even lower.
  
  
  CONCLUSIONS
  NSP upregulates in early periods of sustained spinal cord compression.
authors.affiliation: Department of Orthopedics Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
authors.forename: Shengcheng
authors.initials: S
authors.lastname: Wan
authors.forename: Zhenzhou
authors.initials: Z
authors.lastname: Feng
authors.forename: Zixian
authors.initials: Z
authors.lastname: Chen
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wang
authors.forename: Yuanwu
authors.initials: Y
authors.lastname: Cao
authors.forename: Yunchao
authors.initials: Y
authors.lastname: Shao
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000818:Animals; D017209:Apoptosis; D015415:Biomarkers / Q000378:metabolism; D049109:Cell Proliferation; D004195:Disease Models, Animal; D008297:Male; D017628:Microglia / Q000378:metabolism / Q000473:pathology; D009046:Motor Neurons / Q000378:metabolism / Q000473:pathology; D009479:Neuropeptides / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015842:Serine Proteinase Inhibitors / Q000378:metabolism*; D015843:Serpins / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology; D013117:Spinal Cord Compression / Q000378:metabolism / Q000473:pathology*; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D015854:Up-Regulation; D000097522:Neuroserpin
chemical_list: D015415:Biomarkers; D009479:Neuropeptides; D018696:Neuroprotective Agents; D015842:Serine Proteinase Inhibitors; D015843:Serpins; D010959:Tissue Plasminogen Activator; D000097522:Neuroserpin