title: Cord blood nesfatin-1 in large for gestational age pregnancies.
abstract: OBJECTIVE
  To investigate possible alterations in cord blood levels of adipokine nesfatin-1 (secreted by adipose tissue and pancreatic β-cells and implicated in glucose metabolism and insulin resistance), as well as insulin, in large (LGA) and appropriate for gestational age (AGA) pregnancies, granted that these groups differ in body fat mass and metabolic/endocrine mechanisms.
  
  
  METHODS
  Cord blood nesfatin-1 and insulin concentrations were prospectively measured in 40 LGA (9 born from diabetic and 31 from non-diabetic mothers) and 20 AGA singleton full-term infants as well as their mothers.
  
  
  RESULTS
  Cord blood nesfatin-1 concentrations were significantly lower in LGA compared to AGA neonates (b=-0.206, SE 0.07, p=0.005). However, cord blood nesfatin-1 concentrations were elevated in infants born from mothers with gestational diabetes mellitus (GDM), compared to those born from non-diabetic mothers, after controlling for group (b=0.190, SE 0.10, p=0.05). Finally, cord blood nesfatin-1 concentrations were lower in cases of vaginal delivery (b=0.11, SE 0.05, p=0.042). Insulin levels were significantly elevated, as customized centiles increased (b=0.004, SE=0.002, p=0.016). No significant correlation was found between insulin and nesfatin-1 in maternal and umbilical cord levels.
  
  
  CONCLUSIONS
  In this study nesfatin-1 levels are decreased in LGA compared to AGA fetuses. Fetal nesfatin-1 concentrations are higher in cases of GDM and cord blood nesfatin-1 concentrations are lower in cases of vaginal delivery.
authors.affiliation: Neonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University, Medical School, Athens, Greece.
authors.forename: Theodora
authors.initials: T
authors.lastname: Boutsikou
authors.forename: Despina D
authors.initials: DD
authors.lastname: Briana
authors.forename: Maria
authors.initials: M
authors.lastname: Boutsikou
authors.forename: George
authors.initials: G
authors.lastname: Kafalidis
authors.forename: Despoina
authors.initials: D
authors.lastname: Piatopoulou
authors.forename: Stavroula
authors.initials: S
authors.lastname: Baka
authors.forename: Demetrios
authors.initials: D
authors.lastname: Hassiakos
authors.forename: Demetrios
authors.initials: D
authors.lastname: Gourgiotis
authors.forename: Ariadne
authors.initials: A
authors.lastname: Malamitsi-Puchner
mesh_terms: D002135:Calcium-Binding Proteins / Q000097:blood*; D004268:DNA-Binding Proteins / Q000097:blood*; D003710:Demography; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood; D009035:Mothers; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D011247:Pregnancy
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D007328:Insulin; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins