title: The physiology and pathophysiology of a novel angiotensin receptor-binding protein ATRAP/Agtrap.
abstract: The Ang II type 1 receptor (AT1R)-associated protein (ATRAP/Agtrap) is a molecule specifically interacting with the carboxyl- terminal domain of AT1R. The results of in vitro studies showed that ATRAP suppresses Ang II-mediated pathological responses in cardiovascular cells by promoting AT1R internalization. With respect to the tissue distribution and regulation of ATRAP expression in vivo, ATRAP is broadly expressed in many tissues as is AT1R. Accumulating evidence indicates that a tissue-specific regulatory balancing of ATRAP and AT1R expression may be involved in the modulation of AT1R signaling at local tissue sites and also in the pathophysiology of hypertension and its associated end-organ injury. Furthermore, the activation of ATRAP in transgenic-models inhibited inflammatory vascular remodeling and cardiac hypertrophy in response to Ang II stimulation. These results suggest the clinical potential benefit of an ATRAP activation strategy in the treatment of hypertension and related organ injury.
authors.affiliation: Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. tamukou@med.yokohama-cu.ac.jp
authors.forename: Kouichi
authors.initials: K
authors.lastname: Tamura
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Wakui
authors.forename: Akinobu
authors.initials: A
authors.lastname: Maeda
authors.forename: Toru
authors.initials: T
authors.lastname: Dejima
authors.forename: Masato
authors.initials: M
authors.lastname: Ohsawa
authors.forename: Kengo
authors.initials: K
authors.lastname: Azushima
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Kanaoka
authors.forename: Sona
authors.initials: S
authors.lastname: Haku
authors.forename: Kazushi
authors.initials: K
authors.lastname: Uneda
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Masuda
authors.forename: Koichi
authors.initials: K
authors.lastname: Azuma
authors.forename: Atsu-ichiro
authors.initials: A
authors.lastname: Shigenaga
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Koide
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tsurumi-Ikeya
authors.forename: Miyuki
authors.initials: M
authors.lastname: Matsuda
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Toya
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tokita
authors.forename: Akio
authors.initials: A
authors.lastname: Yamashita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Umemura
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000032:analysis / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D006801:Humans; D017434:Protein Structure, Tertiary; D044140:Receptor, Angiotensin, Type 1 / Q000502:physiology
chemical_list: C449676:AGTRAP protein, human; D048868:Adaptor Proteins, Signal Transducing; D044140:Receptor, Angiotensin, Type 1