title: [Exenatide stimulated solute-free water excretion by human kidney].
abstract: Exenatide effect was studied in 55 human including 38 patients with type 2 diabetes mellitus without signs of diabetic nephropathy and primary renal diseases. Preliminary study with water load in volume from 0.5 to 1% b.w. showed that water load equal to 0.7% b.w. caused significant increase in urine excretion. The rise of diuresis after 10 microg Byetta (exenatide) injection and simultaneous water load of 0.7% of b.w. depended on increase in solute-free water clearance. Thus, exenatide (mimetic of GLP-1) action let us to consider its possible role as component of osmoregulation system in human. This peptide provides high efficiency of renal function in osmotic homeostasis.
authors.forename: E I
authors.initials: EI
authors.lastname: Shakhmatova
authors.forename: Zh V
authors.initials: ZhV
authors.lastname: Shutskaia
authors.forename: M E
authors.initials: ME
authors.lastname: Vladimirova
authors.forename: A I
authors.initials: AI
authors.lastname: Gorelov
authors.forename: A I
authors.initials: AI
authors.lastname: Gorbunov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Natochin
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology; D004231:Diuresis / Q000187:drug effects; D000077270:Exenatide; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009995:Osmosis / Q000187:drug effects*; D010455:Peptides / Q000008:administration & dosage*; D014688:Venoms / Q000008:administration & dosage*; D014867:Water / Q000378:metabolism*
chemical_list: D007004:Hypoglycemic Agents; D010455:Peptides; D014688:Venoms; D014867:Water; D000077270:Exenatide