title: Improved outcome for children with non-high risk acute lymphoblastic leukaemia after using an ALL IC-BFM 2002-based protocol in Shanghai, China.
abstract: We report the outcome of 92 non-high risk children with acute lymphoblastic leukaemia (ALL) following a Berlin-Frankfürt-Münster (BFM) Intercontinental ALL -based protocol. Compared with a matched historical control group, we found a lower incidence of treatment-related early death (1·2% vs. 10·9%, P = 0·015), a higher 6-year event-free survival (75·4 ± 4·9% vs. 58·2 ± 6·7%, P = 0·02), reduced total in-hospital costs per person (US $) (10267·0 vs. 18331·0, P < 0·001) and fewer total in-hospital days (164 vs. 296, P < 0·001). This ALL-BFM based protocol was quite tolerable in our institution and will be extended to high-risk patients.
authors.affiliation: Children's Hospital, Shanghai Medical College, Fudan University, Shanghai, China. gaoyijin@hotmail.com
authors.forename: Yi-Jin
authors.initials: YJ
authors.lastname: Gao
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Qian
authors.forename: Feng-Juan
authors.initials: FJ
authors.lastname: Lu
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Zhai
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D002648:Child; D002675:Child, Preschool; D002681:China; D016371:Cranial Irradiation; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy; D007223:Infant; D060046:Maintenance Chemotherapy; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality* / Q000628:therapy*; D016896:Treatment Outcome