title: Synthesis and use of a trifluoromethylated azomethine ylide precursor.
abstract: The presence of fluorous substituents can impart a dramatic effect on the efficacy of molecules used for a range of applications in society. Here, we describe the preparation and use of a new trifluoromethylated azomethine ylide precursor, which leads to a series of fluorinated pyrrolidine, 3-pyrroline, and pyrrole building blocks.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
authors.forename: Gaël
authors.initials: G
authors.lastname: Tran
authors.forename: Robin
authors.initials: R
authors.lastname: Meier
authors.forename: Lawrence
authors.initials: L
authors.lastname: Harris
authors.forename: Duncan L
authors.initials: DL
authors.lastname: Browne
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D005617:Chlorofluorocarbons, Methane / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D005617:Chlorofluorocarbons, Methane; D013882:Thiosemicarbazones; C512188:azomethine; C009554:fluoroform