title: Juniperolide A: a new polyketide isolated from a terrestrial actinomycete, Streptomyces sp.
abstract: A new linear polyketide, juniperolide A (1), was produced by the terrestrial actinomycete (Lv1-48) isolated from the rhizosphere of the plant Juniperus excelsa. The juniperolide A (1) structure contains a THP unit and a 3-amino-2,3,6-trideoxyhexose as the glycosidic moiety. Mosher's analysis was used for absolute stereochemistry determinations at C-2, C-8, C-20, and C-4', while the relative stereochemistry assignments of the remaining stereocenters were based on ROESY correlations and J-based coupling.
authors.affiliation: Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Pharmaceutical Biotechnology, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany.
authors.forename: Ritesh
authors.initials: R
authors.lastname: Raju
authors.forename: Oleksandr
authors.initials: O
authors.lastname: Gromyko
authors.forename: Viktor
authors.initials: V
authors.lastname: Fedorenko
authors.forename: Andriy
authors.initials: A
authors.lastname: Luzhetskyy
authors.forename: Alberto
authors.initials: A
authors.lastname: Plaza
authors.forename: Rolf
authors.initials: R
authors.lastname: Müller
mesh_terms: D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D061065:Polyketides; C578412:juniperolide A