title: An emerging role for microRNAs in NF1 tumorigenesis.
abstract: MicroRNAs (miRNAs) are a class of non-coding RNA, which have recently been shown to have a wide variety of regulatory functions in relation to gene expression. Since their identification nearly 20 years ago, miRNAs have been found to play an important role in cancer, including in neurofibromatosis type 1 (NF1)-associated tumours. NF1 is the most commonly inherited tumour predisposition syndrome and can lead to malignancy via the development of malignant peripheral nerve sheath tumours (MPNSTs). Although the mechanisms by which benign neurofibromas develop into MPNSTs still remain to be elucidated, it is becoming increasingly clear that miRNAs play a key role in this process and have the potential to be used as both diagnostic and prognostic markers of tumorigenesis.
authors.affiliation: Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
authors.forename: Ashni
authors.initials: A
authors.lastname: Sedani
authors.forename: David N
authors.initials: DN
authors.lastname: Cooper
authors.forename: Meena
authors.initials: M
authors.lastname: Upadhyaya
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009442:Neurilemmoma / Q000150:complications / Q000235:genetics; D009455:Neurofibroma / Q000150:complications / Q000235:genetics; D009456:Neurofibromatosis 1 / Q000150:complications / Q000235:genetics*
chemical_list: D035683:MicroRNAs