title: Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1.
abstract: HIV and hepatitis B virus co-infection leads to substantially increased morbidity and mortality compared with either infection alone. Immunisation with hepatitis B virus vaccine is the most effective way to prevent the infection in people with HIV; however, these patients have decreased vaccine responses and a short duration of protection compared with immunocompetent individuals. Control of HIV replication with highly active antiretroviral therapy and increased CD4 cell counts are associated with improved immune responses to hepatitis B vaccination. New vaccination strategies, such as increased vaccine dose, use of the intradermal route, and addition of adjuvants, could improve response rates in adults with HIV.
authors.affiliation: Division of Infectious Diseases, Emory University School of Medicine, The Hope Clinic of the Emory Vaccine Center, Decatur, GA, USA. jeni.whitaker@gmail.com
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Whitaker
authors.forename: Nadine G
authors.initials: NG
authors.lastname: Rouphael
authors.forename: Srilatha
authors.initials: S
authors.lastname: Edupuganti
authors.forename: Lilin
authors.initials: L
authors.lastname: Lai
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mulligan
mesh_terms: D005260:Female; D017408:Guidelines as Topic; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control* / Q000821:virology*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male; D014611:Vaccination / Q000379:methods / Q000592:standards
chemical_list: D017325:Hepatitis B Vaccines