title: The role of SMAC mimetics in regulation of tumor cell death and immunity.
abstract: Mimetics of second mitochondria-derived activator of caspases (SMAC) enhance tumor cell death in a variety of cancers. Several molecular mechanisms of action have been identified. However, it was only recently that the modus of action was linked to stimulation of anti-tumor immunity. Here we comment on these findings, highlighting several remaining questions.
authors.affiliation: Laboratory of Molecular and Cellular Therapy; Department of Immunology-Physiology; Vrije Universiteit Brussel; Laarbeeklaan, Jette, Belgium.
authors.forename: Perpetua U
authors.initials: PU
authors.lastname: Emeagi
authors.forename: Kris
authors.initials: K
authors.lastname: Thielemans
authors.forename: Karine
authors.initials: K
authors.lastname: Breckpot