title: TAMable tumor-associated macrophages in response to innate RNA sensing.
abstract: Antitumor effect of PolyI:C (a viral dsRNA analog) has been attributed to dendritic cell (DC)-maturation activity, that drives antitumor NK cells, DC cross-presentation, cytotoxic T lymphocytes and many IFN-inducible genes. According to a recent paper, tumor-infiltrating M2 macrophages are found to become an additional antitumor effector through polyI:C response.
authors.affiliation: Department of Microbiology and Immunology; Graduate School of Medicine; Hokkaido University; Sapporo, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Seya
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shime
authors.forename: Misako
authors.initials: M
authors.lastname: Matsumoto