title: Perinatal risk factors for bronchopulmonary dysplasia in a national cohort of very-low-birthweight infants.
abstract: OBJECTIVE
  We sought to assess the independent effect of perinatal factors on the risk for bronchopulmonary dysplasia (BPD) in very-low-birthweight infants.
  
  
  METHODS
  This was a population-based observational study. Data were prospectively collected by the Israel Neonatal Network. Multivariable analyses identified independent risk factors for BPD.
  
  
  RESULTS
  Of 12,139 infants surviving to a postmenstrual age of 36 weeks, 1663 (13.7%) developed BPD. BPD was independently associated with young maternal age (odds ratio [OR], 1.53), maternal hypertensive disorders (OR, 1.28), antepartum hemorrhage (OR, 1.26), male gender (OR, 1.41), non-Jewish ethnicity (OR, 1.23), birth defects (OR, 1.94), small for gestational age (GA) (OR, 2.65), and delivery room resuscitation (OR, 1.86). Stratified analysis by GA groups showed that postdelivery resuscitation had a more pronounced effect with increasing maturity.
  
  
  CONCLUSIONS
  Perinatal factors and pregnancy complications were independently associated with development of BPD in very-low-birthweight infants. Most risk factors identified were consistent within GA groups.
authors.affiliation: Neonatal Intensive Care Unit, Schneider Children's Medical Center of Israel, Petah Tikva, Israel. gilkl@post.tau.ac.il
authors.forename: Gil
authors.initials: G
authors.lastname: Klinger
authors.forename: Nir
authors.initials: N
authors.lastname: Sokolover
authors.forename: Valentina
authors.initials: V
authors.lastname: Boyko
authors.forename: Lea
authors.initials: L
authors.lastname: Sirota
authors.forename: Liat
authors.initials: L
authors.lastname: Lerner-Geva
authors.forename: Brian
authors.initials: B
authors.lastname: Reichman
mesh_terms: D000293:Adolescent; D000328:Adult; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology*; D016887:Cardiopulmonary Resuscitation; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007557:Israel / Q000453:epidemiology; D008297:Male; D008423:Maternal Age; D058725:Peripartum Period; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult