title: Self-limiting hematuria following growth hormone provocative testing with arginine hydrochloride.
abstract: Evaluation of growth hormone (GH) deficiency often involves use of agents that stimulate GH secretion, such as clonidine, glucagon, insulin, levo-dopa or arginine hydrochloride. We present three pediatric cases of benign, macroscopic hematuria in children without pre-existing renal disease following GH stimulation testing with clonidine and arginine hydrochloride. In all cases hematuria resolved spontaneously within 3-4 days without any intervention. This suggests that careful observation in such cases is sufficient and additional costly evaluation may be avoided. Other than six anecdotal cases registered via on-line adverse event reporting system (AERS), this is the first published report to date of painless, macroscopic, self-limiting hematuria after arginine hydrochloride infusion.
authors.affiliation: University of California San Diego and Rady Children's Hospital San Diego, 3020 Children's Way, MC 5103, San Diego, CA 92123, USA. mmarinkovic@ucsd.edu
authors.forename: Maja
authors.initials: M
authors.lastname: Marinkovic
authors.forename: Ron S
authors.initials: RS
authors.lastname: Newfield
mesh_terms: D001120:Arginine / Q000009:adverse effects* / Q000737:chemistry; D002648:Child; D003000:Clonidine / Q000009:adverse effects; D003940:Diagnostic Techniques, Endocrine / Q000009:adverse effects*; D018450:Disease Progression; D006417:Hematuria / Q000139:chemically induced* / Q000473:pathology; D019382:Human Growth Hormone / Q000032:analysis* / Q000097:blood / Q000172:deficiency; D006801:Humans; D006851:Hydrochloric Acid / Q000009:adverse effects* / Q000737:chemistry; D008297:Male
chemical_list: D019382:Human Growth Hormone; D001120:Arginine; D003000:Clonidine; D006851:Hydrochloric Acid