title: First clinical cases of OXA-48-producing carbapenem-resistant Klebsiella pneumoniae in the United States: the "menace" arrives in the new world.
abstract: OXA-48 has emerged as a major carbapenemase associated with the Enterobacteriaceae in Europe, North Africa, and Asia. We report the first two clinical cases of OXA-48-type carbapenemase-producing Enterobacteriaceae in the United States from patients recently hospitalized in Saudi Arabia and India. Each is more carbapenem resistant than nearly all previously reported OXA-48-type-producing Enterobacteriaceae.
authors.affiliation: Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA. ajm5b@virginia.edu
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Mathers
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Hazen
authors.forename: Joanne
authors.initials: J
authors.lastname: Carroll
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Yeh
authors.forename: Heather L
authors.initials: HL
authors.lastname: Cox
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bonomo
authors.forename: Costi D
authors.initials: CD
authors.lastname: Sifri
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000175:diagnosis / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000145:classification* / Q000187:drug effects* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D014481:United States; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C108449:oxacillinase