title: A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility.
abstract: OBJECTIVE
  Many reported studies have been conducted to investigate the association of angiotensin II type 1 receptor (AT1R) A1166C gene polymorphism with myocardial infarction (MI) susceptibility. However, the results from those reports are still conflicting. This meta-analysis was performed to study the relationship between AT1R A1166C gene polymorphism and MI risk.
  
  
  METHODS
  The databases of PubMed, Embase, and Cochrane Library were searched as of 1 March 2012, and eligible investigations were recruited into this meta-analysis.
  
  
  RESULTS
  Eighteen investigations were identified for the analysis of association between AT1R A1166C gene polymorphism and MI risk, 11 in Caucasians, three in Asians, two in Africans, one in the population of Brazil and one in the population of Durban, South Africa . There was a marked association between AT1R C allele and MI susceptibility for overall populations (odds ratio (OR)=1.12, 95% confidence interval (CI): 1.01-1.25, p=0.03), and AT1R AA genotype was associated with a lower risk of MI in overall populations (OR=0.87, 95% CI: 0.78-0.98, p=0.02). However, AT1R A1166C gene polymorphism was not associated with MI risk in the sub-groups of Caucasians, Asians, Africans, Brazil and Durban populations.
  
  
  CONCLUSIONS
  C allele is a risk factor for the MI susceptibility in overall populations, and AA genotype might be a protective factor against the MI risk in overall populations. However, more case-control association investigations on larger, stratified populations are required in the future.
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, China.
authors.forename: Bao-Shi
authors.initials: BS
authors.lastname: Zheng
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, China.
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Shi
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, China.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, China zhouhuafudr@sina.com.
authors.forename: Hua-Fu
authors.initials: HF
authors.lastname: Zhou
mesh_terms: D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D044140:Receptor, Angiotensin, Type 1