title: Interleukin 33 mediates type 2 immunity and inflammation in the central nervous system of mice infected with Angiostrongylus cantonensis.
abstract: Angiostrongylus cantonensis can induce central nervous system (CNS) injury and cause human eosinophilic meningitis. The CNS has been found to have high expression of interleukin 33 (IL-33), which promotes the pathogenesis of T-helper 2 (Th2)-related disease. Given the predominantly type 2 response induced by A. cantonensis-infected mice and human, it is likely that IL-33 may play a role in aiding this process. We report here that IL-33 protein and ST2L messenger RNA (mRNA) transcripts in the brains were upregulated during A. cantonensis infection and that both splenocytes and brain mononuclear cells became IL-33 responsive and produced interleukin 5 and interleukin 13. Furthermore, administration of IL-33 to A. cantonensis-infected mice enhanced ST2L expression and cytokine production. Interestingly, brain IL-33 protein and ST2L mRNA levels were elevated 14-21 days after infection in BALB/c mice, compared with C57BL/6 mice. Thus, our data indicate that IL-33 produced in the brain may function as an inflammatory mediator in eosinophilic meningitis induced by A. cantonensis.
authors.affiliation: Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Peng
authors.forename: Rui
authors.initials: R
authors.lastname: Sun
authors.forename: Qixian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jia
authors.initials: J
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.forename: Xin
authors.initials: X
authors.lastname: Zeng
authors.forename: Huanqin
authors.initials: H
authors.lastname: Zheng
authors.forename: Zhongdao
authors.initials: Z
authors.lastname: Wu
mesh_terms: D017185:Angiostrongylus cantonensis / Q000276:immunology* / Q000472:pathogenicity*; D000818:Animals; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology*; D004195:Disease Models, Animal; D015870:Gene Expression; D006801:Humans; D000067596:Interleukin-33; D007378:Interleukins / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009000:Monocytes / Q000276:immunology; D017472:Receptors, Interleukin-1 / Q000096:biosynthesis; D013154:Spleen / Q000276:immunology; D017206:Strongylida Infections / Q000276:immunology* / Q000473:pathology*; D018418:Th2 Cells / Q000276:immunology
chemical_list: C506535:Il33 protein, mouse; D000067596:Interleukin-33; D007378:Interleukins; D017472:Receptors, Interleukin-1; C530318:ST2L protein, mouse