title: Agent-based model of macrophage action on endocrine pancreas.
abstract: This paper proposes an agent-based model of the action of macrophages on the beta cells of the endocrine pancreas. The aim of this model is to simulate the processes of beta cell proliferation and apoptosis and also the process of phagocytosis of cell debris by macrophages, all of which are related to the onset of the autoimmune response in type 1 diabetes. We have used data from the scientific literature to design the model. The results show that the model obtains good approximations to real processes and could be used to shed light on some open questions concerning such processes.
authors.affiliation: Grupo de Bioingeniería y Telemedicina, Departamento de Tecnologia Fotónica, Universidad Politécnica de Madrid, Avenida Complutense 30, 28040 Madrid, Spain. ivme@gbt.tfo.upm.es
authors.forename: Ignacio V
authors.initials: IV
authors.lastname: Martínez
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Gómez
authors.forename: M Elena
authors.initials: ME
authors.lastname: Hernando
authors.forename: Ricardo
authors.initials: R
authors.lastname: Villares
authors.forename: Mario
authors.initials: M
authors.lastname: Mellado
mesh_terms: D017209:Apoptosis; D049109:Cell Proliferation; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D008962:Models, Theoretical; D010587:Phagocytosis