title: Epidermal growth factor receptor mutations in female patients with postoperative recurrent non-small-cell lung cancer.
abstract: OBJECTIVE
  We did this retrospective study to explore the association between epidermal growth factor receptor (EGFR) mutation and clinical features in postoperative recurrent female non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  We reviewed clinical data on 86 female patients who had postoperative recurrent disease between December 1992 and July 2007. The start of tyrosine kinase inhibitor therapy was treated as a censoring event. Corresponding surgical specimens of primary tumors were used to test for EGFR mutations.
  
  
  RESULTS
  Thirty patients presented with local recurrence and distant recurrence was identified in 56. Thirty-four of the 86 patients (40%) harbored EGFR mutations. Patients with distant recurrence were more likely to have EGFR mutations than patients with local recurrence (48% versus 23%; P = 0.024). On multivariate analysis, distant recurrence was associated with a high frequency of EGFR mutations (OR, 3.3; P = 0.028). Survival analysis showed poor survival of patients with mutated EGFR (HR, 2.3; P = 0.017) or with non-adenocarcinoma histology (HR, 3.3; P = 0.001).
  
  
  CONCLUSIONS
  The association between recurrence pattern and EGFR mutation status was suggested in recurrent female NSCLC patients. In addition, our data indicate unfavorable disease process of EGFR mutated tumors. Further studies need to be conducted to validate these findings.
authors.affiliation: Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Korea. hmona71@gmail.com
authors.forename: Im Il
authors.initials: II
authors.lastname: Na
authors.forename: Hye-Ryoun
authors.initials: HR
authors.lastname: Kim
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Lee
authors.forename: Sun Hoo
authors.initials: SH
authors.lastname: Park
authors.forename: Cheol Hyeon
authors.initials: CH
authors.lastname: Kim
authors.forename: Jae Soo
authors.initials: JS
authors.lastname: Koh
authors.forename: Hee Jong
authors.initials: HJ
authors.lastname: Baek
authors.forename: Du Hwan
authors.initials: du H
authors.lastname: Choe
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics / Q000401:mortality / Q000601:surgery; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000401:mortality / Q000601:surgery; D008875:Middle Aged; D009154:Mutation; D009362:Neoplasm Metastasis / Q000235:genetics*; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D012189:Retrospective Studies; D013534:Survival; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases