title: Helicobacter pylori infection in India from a western perspective.
abstract: Helicobacter pylori is a common bacterial infectious disease whose manifestations predominately affect the gastrointestinal tract. India is the prototypical developing country as far as H. pylori infection is concerned and more than 20 million Indians are estimated to suffer from peptic ulcer disease. Considering the high level of medical research and of the pharmaceutical industry, one would expect that India would be the source of much needed information regarding new therapies and approaches that remain effective in the presence of antimicrobial resistance, new methods to reliably prevent reinfection, and the development of therapeutic and preventive vaccines. Here we discuss H. pylori as a problem in India with an emphasis on H. pylori infection as a serious transmissible infectious disease. We discuss the pros and cons of eradication of H. pylori from the entire population and come down on the side of eradication. The available data from India regarding antimicrobial use and resistance as well as the effectiveness of various treatments are discussed. Rigorous ongoing studies to provide current regional antibiotic resistance patterns coupled with data concerning the success rate with different treatment regimens are needed to guide therapy. A systematic approach to identify reliably effective (e.g., 90% or greater treatment success) cost-effective regimens is suggested as well as details of regimens likely to be effective in India. H. pylori is just one of the health care problems faced in India, but one where all the resources are on hand to understand and solve it.
authors.affiliation: Department of Medicine, Michael E. DeBakey VA Medical Center, Houston, Texas 77030, USA. dgraham@bcm.edu
authors.forename: Selvi
authors.initials: S
authors.lastname: Thirumurthi
authors.forename: David Y
authors.initials: DY
authors.lastname: Graham
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D060740:Disease Eradication / Q000379:methods / Q000639:trends*; D004352:Drug Resistance, Microbial; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000517:prevention & control*; D016480:Helicobacter pylori; D006801:Humans; D007194:India / Q000453:epidemiology; D011640:Public Policy / Q000191:economics*
chemical_list: D000890:Anti-Infective Agents