title: The synthesis of chiral isotetronic acids with amphiphilic imidazole/pyrrolidine catalysts assembled in oil-in-water emulsion droplets.
abstract: Drop it! A highly enantioselective catalytic cascade reaction of α-ketoacids and aldehydes is achieved using the title catalyst and water as the solvent. Fluorescence imaging shows that the catalyst is mainly distributed on the surface of emulsion droplets. Optically active isotetronic acids can be obtained with this method and the emulsion droplets are responsible for the high reactivity and enantioselectivity.
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China.
authors.forename: Boyu
authors.initials: B
authors.lastname: Zhang
authors.forename: Zongxuan
authors.initials: Z
authors.lastname: Jiang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Shengmei
authors.initials: S
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Can
authors.initials: C
authors.lastname: Li
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D004655:Emulsions / Q000737:chemistry; D005421:Flavoring Agents / Q000138:chemical synthesis / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D008823:Micelles; D008856:Microscopy, Fluorescence; D009821:Oils / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D004655:Emulsions; D005421:Flavoring Agents; D005663:Furans; D007093:Imidazoles; D008823:Micelles; D009821:Oils; D011759:Pyrrolidines; D014867:Water; C029899:imidazole; C032519:pyrrolidine; C003422:tetronic acid