title: Characteristic imaging features of desmoplastic small round cell tumour.
abstract: BACKGROUND
  Desmoplastic small round cell tumour (DSRCT) is a rare malignant neoplasm. Its radiological features have rarely been described.
  
  
  OBJECTIVE
  To assess the CT parameters characteristic of DSRCT. We also report our experience with combined FDG PET/CT in staging and follow-up for DSRCT.
  
  
  METHODS
  The pretreatment diagnostic CT's of 65 patients with DSRCT were evaluated. Pertinent imaging findings were catalogued, with histopathology or serial follow-up studies as reference standard. Combined FDG PET/CT examinations of 11 of these patients who underwent pretreatment imaging were also reviewed.
  
  
  RESULTS
  Sixty-two patients presented with primary intra-abdominal disease; three had primary extra-abdominal tumours at presentation. The most common imaging finding of patients with intra-abdominal DSRCT was multiple peritoneal soft tissue masses, with a dominant mass in the retrovesical or rectouterine location in more than half of the cases. Forty percent had metastatic disease to the liver, lungs, spleen or bones at diagnosis. FDG PET/CT accurately detected 97.4% of all DSRCT lesions.
  
  
  CONCLUSIONS
  DSRCT typically presents as a large abdominopelvic mass with widespread peritoneal involvement predominantly in young males. Familiarity with its radiological features can help guide diagnosis and treatment. Functional imaging with PET/CT offers advantage over anatomical imaging for accurate disease staging.
authors.affiliation: Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA. ena_79@hotmail.com
authors.forename: Vandan Caur
authors.initials: VC
authors.lastname: Arora
authors.forename: Anita P
authors.initials: AP
authors.lastname: Price
authors.forename: Stephen
authors.initials: S
authors.lastname: Fleming
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Sohn
authors.forename: Heather
authors.initials: H
authors.lastname: Magnan
authors.forename: Michael P
authors.initials: MP
authors.lastname: LaQuaglia
authors.forename: Sara
authors.initials: S
authors.lastname: Abramson
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology; D002648:Child; D058405:Desmoplastic Small Round Cell Tumor / Q000473:pathology*; D004067:Digestive System Neoplasms / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D019042:Muscle Neoplasms / Q000473:pathology; D009362:Neoplasm Metastasis; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000473:pathology; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18