title: Association between depression, nutritional status, and inflammatory markers in peritoneal dialysis patients.
abstract: BACKGROUND
  To investigate the relationship between depression, nutritional status, and inflammatory markers in patients on peritoneal dialysis (PD).
  
  
  METHODS
  This prospective study included 40 PD patients and 20 healthy people. The severity of depressive symptoms was assessed using the Beck depression inventory, the Hamilton depression rating scale, and the Hamilton anxiety rating scale. The depressive patients received antidepressant drug for 8 weeks. Blood samples were taken before and after antidepressant treatment for the high-sensitive C-reactive protein (hs-CRP), interleukin (IL)-1, IL-6, and tumor necrosis factor-α (TNF-α) levels.
  
  
  RESULTS
  Ten (25%) of the 40 PD patients had depression. No significant difference was determined between depressive patients and nondepressive patients. The mean erythrocyte sedimentation rate was higher in depressive patients. There was no significant difference for other inflammation parameters, including hs-CRP, TNF-α, IL-1, and IL-6, between depressive patients and nondepressive patients. In the depressive patients, we did not observe any significant change in nutritional parameters after antidepressant treatment. When we evaluated inflammation parameters of the depressive patients before and after antidepressant treatment, only IL-1 and IL-6 levels were significantly increased after antidepressant treatment.
  
  
  CONCLUSIONS
  The depressive disorder in PD patients is a common psychopathology and has no significant effects on nutritional status and inflammation.
authors.affiliation: Department of Nephrology, Erciyes University Medical Faculty, Kayseri, Turkey. havvacilan@gmail.com
authors.forename: Havva
authors.initials: H
authors.lastname: Cilan
authors.forename: Murat Hayri
authors.initials: MH
authors.lastname: Sipahioglu
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Oguzhan
authors.forename: Aydin
authors.initials: A
authors.lastname: Unal
authors.forename: Tayfun
authors.initials: T
authors.lastname: Turan
authors.forename: Ayse Nedret
authors.initials: AN
authors.lastname: Koc
authors.forename: Bulent
authors.initials: B
authors.lastname: Tokgoz
authors.forename: Cengiz
authors.initials: C
authors.lastname: Utas
authors.forename: Oktay
authors.initials: O
authors.lastname: Oymak
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016207:Cytokines / Q000097:blood*; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D008297:Male; D009752:Nutritional Status; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D000928:Antidepressive Agents; D015415:Biomarkers; D016207:Cytokines; D002097:C-Reactive Protein