title: Effect of gender on the association between weight status and health-related quality of life in adolescents.
abstract: BACKGROUND
  Some studies have investigated the association between body mass index (BMI) and health-related quality of life (HRQoL) among adolescents, but their results have been discrepant and few paid attention to the role of gender. The present investigation aimed to assess the relationship between weight status and HRQoL in adolescents and to verify whether it was similar in boys and girls.
  
  
  METHODS
  Five thousand two hundred and twenty six adolescents aged 14 to 18 years were included in the PRomotion de l'ALIMentation et de l'Activité Physique (PRALIMAP) trial, a 2x2x2 factorial cluster randomized trial performed in 24 high schools in France. Sociodemographic, anthropometric and HRQoL data were collected. BMI was categorized in four classes (thin, normal-weight, overweight, obese). Linear regression models were used to estimate the association between weight status and HRQoL, adjusting for confounders.
  
  
  RESULTS
  The mean age of adolescents was 15.7±0.6 years and their mean BMI was 21.6 ±3.5 kg/m2; 55% were girls. Boys were more often overweight and obese than were girls (overweight: 15.6% vs 14.2%, obese: 4.8% vs 3.3%), and girls were more likely to be thin (5.5% vs 4.5%, p=0.0042). All HRQoL scores were higher for boys (p=<0.0001). Weight status was not associated with physical and social scores neither in boys nor in girls. Conversely, it was associated with mental score, but differently in girls than boys. As compared with normal-weight girls, thin girls had better mental HRQoL (β=+6.17, p=0.0010), and overweight and obese girls had lower mental HRQoL (β=-3.89 and β=-5.90, respectively, p<0.001). Mental HRQoL was lower for thin, overweight and obese boys than for normal-weight boys (β= -4.97, β= -1.68 and β= -3.17, respectively, p<0.0001).
  
  
  CONCLUSIONS
  Gender can modify the association between weight status and HRQoL in adolescents. Body image could be an important target of public health programs to improve subjective health during adolescence.
authors.affiliation: University of Lorraine, Paris Descartes University, EA4360, Apemac, Nancy, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Bonsergent
authors.forename: Joseph
authors.initials: J
authors.lastname: Benie-Bi
authors.forename: Cédric
authors.initials: C
authors.lastname: Baumann
authors.forename: Nelly
authors.initials: N
authors.lastname: Agrinier
authors.forename: Sabrina
authors.initials: S
authors.lastname: Tessier
authors.forename: Nathalie
authors.initials: N
authors.lastname: Thilly
authors.forename: Serge
authors.initials: S
authors.lastname: Briançon
mesh_terms: D000293:Adolescent; D001828:Body Image; D015992:Body Mass Index; D005260:Female; D005602:France; D006304:Health Status; D006801:Humans; D008297:Male; D011788:Quality of Life; D012737:Sex Factors; D011795:Surveys and Questionnaires