title: Non-fouling hydrogels of 2-hydroxyethyl methacrylate and zwitterionic carboxybetaine (meth)acrylamides.
abstract: Five poly(betaine) brushes were prepared, and their resistance to blood plasma fouling was studied. Two carboxybetaines monomers were copolymerized with 2-hydroxyethyl methacrylate (HEMA) to prepare novel hydrogels. By increasing the content of the zwitterionic comonomer, a 4-fold increase in the water content could be achieved while retaining mechanical properties close to the widely used poly(HEMA) hydrogels. All hydrogels showed an unprecedentedly low fouling from blood plasma. Remarkably, by copolymerization with 10 mol % of carboxybetaine acrylamide, hydrogels fully resistant to blood plasma were prepared.
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i., Prague, 16206, Czech Republic.
authors.forename: Nina Yu
authors.initials: NY
authors.lastname: Kostina
authors.forename: Cesar
authors.initials: C
authors.lastname: Rodriguez-Emmenegger
authors.forename: Milan
authors.initials: M
authors.lastname: Houska
authors.forename: Eduard
authors.initials: E
authors.lastname: Brynda
authors.forename: Jiří
authors.initials: J
authors.lastname: Michálek
mesh_terms: D000178:Acrylamides / Q000138:chemical synthesis*; D001622:Betaine / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis*; D008689:Methacrylates / Q000138:chemical synthesis*; D010949:Plasma / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D020349:Surface Plasmon Resonance; D013499:Surface Properties; D014867:Water / Q000737:chemistry
chemical_list: D000178:Acrylamides; D001672:Biocompatible Materials; D020100:Hydrogels; D008689:Methacrylates; D011108:Polymers; D014867:Water; D001622:Betaine; C005044:hydroxyethyl methacrylate