title: Urological surgery in patients with hemorrhagic bleeding disorders Hemophilia A, Hemophilia B, von Willebrand disease: a retrospective study with matched pairs analysis.
abstract: OBJECTIVE
  To determine retrospectively the perioperative management and outcome of transurethral prostate/bladder surgery (TURP, TURB) and transrectal prostate biopsy in hemophiliacs.
  
  
  METHODS
  Thirty-seven hemophilic patients underwent TURP (12 patients), TURB (13 patients), or transrectal prostate biopsy (12 patients) with proactive hemostaseological management (i.e., factor supply, close meshed hemostaseological analysis). Thirty-seven non-hemophiliac patients served as matched pairs who matched for age, gender, accompanying diseases, and the type of surgical procedure. The resulting pairs were analyzed for duration of surgery, hospital stay, and complications.
  
  
  RESULTS
  Average TURP length in hemophiliacs was 77.92 min, in the matched pairs group TURP 67.08 min (p = 0.487). Mean TURB length in hemophiliacs was 43.46 min versus 35.38 min in controls (p = 0.678). More important, the length of hospital stay was significant longer in the hemophiliacs undergoing TURP compared to non-hemophiliac control group (12.08 days vs. 5.83 days; p < 0.001). In TURB patients, similar results were found (11.15 days hemophiliacs vs. 6.15 controls; p = 0.018). Regarding complications (bleeding, hemorrhage, readmission), no significant difference between the groups was obtained.
  
  
  CONCLUSIONS
  Urological interventions in hemophiliac patients with factor supply have the same risk for postoperative complications as in non-hemophiliacs. The only significant difference between hemophiliacs and non-hemophiliacs was the length of hospital stay.
authors.affiliation: Department of Urologie, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany. Sebastian@Rogenhofer.de
authors.forename: Sebastian
authors.initials: S
authors.lastname: Rogenhofer
authors.forename: Stefan
authors.initials: S
authors.lastname: Hauser
authors.forename: Anne
authors.initials: A
authors.lastname: Breuer
authors.forename: Guido
authors.initials: G
authors.lastname: Fechner
authors.forename: Stefan C
authors.initials: SC
authors.lastname: Mueller
authors.forename: Johannes
authors.initials: J
authors.lastname: Oldenburg
authors.forename: Georg
authors.initials: G
authors.lastname: Goldmann
mesh_terms: D000368:Aged; D001706:Biopsy / Q000009:adverse effects*; D016022:Case-Control Studies; D019468:Disease Management; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications*; D006470:Hemorrhage / Q000453:epidemiology*; D006801:Humans; D007902:Length of Stay; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D061646:Operative Time; D011467:Prostate / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000601:surgery; D013520:Urologic Surgical Procedures / Q000009:adverse effects*; D014842:von Willebrand Diseases / Q000150:complications*