title: [Daptomycin for the treatment of gram-positive infections after cardiac surgery].
abstract: METHODS
  Surgical infection remains a main cause of death after heart surgery, despite advances in pharmacological therapy. Daptomycin is a cyclic lipopeptide antibiotic, useful in gram-positive organisms resistant to standard treatment, including vancomycin. The aim of this study was to describe the use of daptomycin regarding efficacy, efficiency and safety in patients with gram-positive infections after heart surgery using a retrospective analysis on 49 adult patients.
  
  
  CONCLUSIONS
  Daptomycin shows excellent in vitro and in vivo activity against gram-positive organisms, such as Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, especially MRSA. Daptomycin is also effective against increasing vancomycin-resistant or vancomycin-intermediate S. aureus.
authors.affiliation: Klinik für Anaesthesiologie, Klinikum der Universität München-Campus Großhadern, Munich, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Luchting
authors.forename: F
authors.initials: F
authors.lastname: Weis
authors.forename: J
authors.initials: J
authors.lastname: Heyn
authors.forename: A
authors.initials: A
authors.lastname: Beiras-Fernandez
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D003422:Critical Care; D003428:Cross Infection / Q000188:drug therapy*; D017576:Daptomycin / Q000009:adverse effects / Q000627:therapeutic use*; D013293:Enterococcus faecalis / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008875:Middle Aged; D010138:Pacemaker, Artificial; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013530:Surgical Wound Infection / Q000188:drug therapy*; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin