title: microRNAs in colon cancer: a roadmap for discovery.
abstract: Cancer omics data are exponentially created and associated with clinical variables, and important findings can be extracted based on bioinformatics approaches which can then be experimentally validated. Many of these findings are related to a specific class of non-coding RNA molecules called microRNAs (miRNAs) (post-transcriptional regulators of mRNA expression). The related research field is quite heterogeneous and bioinformaticians, clinicians, statisticians and biologists, as well as data miners and engineers collaborate to cure stored data and on new impulses coming from the output of the latest Next Generation Sequencing technologies. Here we review the main research findings on miRNA of the first 10 years in colon cancer research with an emphasis on possible uses in clinical practice. This review intends to provide a road map in the jungle of publications of miRNA in colorectal cancer, focusing on data availability and new ways to generate biologically relevant information out of these huge amounts of data.
authors.affiliation: Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland. simona.rossi@isb-sib.ch
authors.forename: Simona
authors.initials: S
authors.lastname: Rossi
authors.forename: Antonio Fabio
authors.initials: AF
authors.lastname: Di Narzo
authors.forename: Pieter
authors.initials: P
authors.lastname: Mestdagh
authors.forename: Bart
authors.initials: B
authors.lastname: Jacobs
authors.forename: Fredrik T
authors.initials: FT
authors.lastname: Bosman
authors.forename: Bengt
authors.initials: B
authors.lastname: Gustavsson
authors.forename: Bernard
authors.initials: B
authors.lastname: Majoie
authors.forename: Arnaud
authors.initials: A
authors.lastname: Roth
authors.forename: Jo
authors.initials: J
authors.lastname: Vandesompele
authors.forename: Isidore
authors.initials: I
authors.lastname: Rigoutsos
authors.forename: Mauro
authors.initials: M
authors.lastname: Delorenzi
authors.forename: Sabine
authors.initials: S
authors.lastname: Tejpar
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D015179:Colorectal Neoplasms / Q000235:genetics; D019295:Computational Biology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D058990:Molecular Targeted Therapy; D011379:Prognosis; D012334:RNA, Neoplasm / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D012334:RNA, Neoplasm