title: Synergistic effects of galantamine and memantine in attenuating scopolamine-induced amnesia in mice.
abstract: We investigated a possible drug efficacy enhancement obtained by combining inactive doses of galantamine and memantine in the scopolamine-induced amnesia model in mice. We evaluated the effects of the two drugs, either alone or in combination, using the spontaneous alternation and object recognition tasks. In both tests, combination of low doses of galantamine (0.1 mg/kg, s.c.) and memantine (0.5 mg/kg, i.p.), which were sub-active per se, rescued the memory impairment induced by scopolamine (1 mg/kg, i.p.). The results suggest that combinations of galantamine and memantine might provide a more effective treatment of memory impairments in cognitive disorders than either drug used alone.
authors.affiliation: Drug Discovery and Development, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.
authors.forename: Perrine
authors.initials: P
authors.lastname: Busquet
authors.forename: Valeria
authors.initials: V
authors.lastname: Capurro
authors.forename: Andrea
authors.initials: A
authors.lastname: Cavalli
authors.forename: Daniele
authors.initials: D
authors.lastname: Piomelli
authors.forename: Angelo
authors.initials: A
authors.lastname: Reggiani
authors.forename: Rosalia
authors.initials: R
authors.lastname: Bertorelli
mesh_terms: D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D000818:Animals; D004195:Disease Models, Animal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005702:Galantamine / Q000008:administration & dosage*; D008297:Male; D008559:Memantine / Q000008:administration & dosage*; D051379:Mice; D008815:Mice, Inbred Strains; D021641:Recognition, Psychology / Q000187:drug effects; D012601:Scopolamine
chemical_list: D005702:Galantamine; D012601:Scopolamine; D008559:Memantine