title: [Free radical modification of proteins in brain structure of Sprague-Dawley rats and some behaviour indicators after prenatal stress].
abstract: We studied the influence of late prenatal stress on free radical oxidation processes in Sprague-Dawley rats cortex, striatum, hippocampus, hypothalamus proteins. It was shown that after prenatal stress most changes were observed in hypothalamus and hippocampus. It was shown that in hypothalamus spontaneous oxidation level increased, but level of induced oxidation decreased, the opposite changes were found in hippocampus. Simultaneously minor changes of protein modification were observed in cortex and striatum. It was shown that prenatal stress changed both correlation of proteins free radical oxidation in studied structures and values of these data regarding to control. In test of "open field" motor activity in rats after prenatal stress decreased and time of freezing and grooming increased; opposite, in T-labyrinth motor activity and time of grooming in rats after prenatal stress increased, but time of freezing decreased.
authors.forename: A V
authors.initials: AV
authors.lastname: V'iushina
authors.forename: A V
authors.initials: AV
authors.lastname: Pritvorova
authors.forename: M A
authors.initials: MA
authors.lastname: Flerov
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D006120:Grooming; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D007031:Hypothalamus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D018782:Maze Learning; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010084:Oxidation-Reduction; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D011499:Protein Processing, Post-Translational; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological
chemical_list: D005609:Free Radicals; D009419:Nerve Tissue Proteins