title: Online monitoring of intelligent polymers for drug release with hyperpolarized xenon.
abstract: Welcome to the guest zone: By combining hyperpolarized xenon and simple low-field NMR devices it is possible to obtain more control over hydrogels that show potential as drug delivery systems. An alternative way of polymer swelling-degree determination is demonstrated with real-time NMR analysis. An ideal region for solvent uptake can be defined in which the absorbed solvent molecules are completely confined in the nano-porous network of the hydrogel.
authors.affiliation: Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany. stgloeggler@gmx.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Glöggler
authors.forename: Markus
authors.initials: M
authors.lastname: Raue
authors.forename: Johannes
authors.initials: J
authors.lastname: Colell
authors.forename: Pierre
authors.initials: P
authors.lastname: Türschmann
authors.forename: Alexander
authors.initials: A
authors.lastname: Liebisch
authors.forename: Thomas
authors.initials: T
authors.lastname: Mang
authors.forename: Bernhard
authors.initials: B
authors.lastname: Blümich
authors.forename: Stephan
authors.initials: S
authors.lastname: Appelt
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000180:Acrylic Resins; D016503:Drug Delivery Systems / Q000379:methods; D020100:Hydrogels / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods; D005741:Noble Gases / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D014978:Xenon / Q000737:chemistry*
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D020100:Hydrogels; D005741:Noble Gases; D011108:Polymers; D012997:Solvents; C052970:poly-N-isopropylacrylamide; D014978:Xenon