title: [Anesthetic management of a patient with Creutzfeldt-Jacob disease undergoing tracheal separation].
abstract: We gave anesthesia for tracheal separation in a patient with Creutzfeldt-Jakob disease. The patient, a 33-year-old woman, was bedridden and unable to communicate, and was going to undergo a tracheal separation procedure for repeated bouts of aspiration pneumonia. After a tracheostomy with local anesthesia and sedation with propofol, general anesthesia was induced and maintained with propofol (1.5-3.0 microg x ml(-1), target controlled infusion) and remifentanil (0.05-0.15 microg x kg(-1) x min(-1)). We did not use an anesthetic apparatus from the standpoint of infection control, and provided manual ventilation with a disposable Jackson-Rees circuit. During the operation, an entropy monitor indicated alternating extremely low (0-10) and high (90-100) values without circulatory change, probably due to a previously existing electroencephalographic abnormality. The surgery was uneventful, and spontaneous breathing and eyelid opening occurred about 10 minutes after discontinuation of remifentanil and propofol. In such infected patients, abnormal prion proteins can exist outside of the central nervous system throughout the period of anesthetic management. Therefore, careful infection control must be undertaken, even if the surgical site is not directly related to the central nervous system.
authors.affiliation: Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima 734-8551.
authors.forename: Rieko
authors.initials: R
authors.lastname: Kanzaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hamada
authors.forename: Hideki
authors.initials: H
authors.lastname: Fukuda
authors.forename: Masashi
authors.initials: M
authors.lastname: Kawamoto
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000379:methods*; D007562:Creutzfeldt-Jakob Syndrome / Q000601:surgery*; D005260:Female; D006801:Humans; D017053:Infection Control / Q000379:methods*; D011015:Pneumonia, Aspiration / Q000517:prevention & control; D015742:Propofol; D055502:Secondary Prevention; D014132:Trachea / Q000601:surgery*
chemical_list: D015742:Propofol