title: The estimation of patient-specific cardiac diastolic functions from clinical measurements.
abstract: An unresolved issue in patients with diastolic dysfunction is that the estimation of myocardial stiffness cannot be decoupled from diastolic residual active tension (AT) because of the impaired ventricular relaxation during diastole. To address this problem, this paper presents a method for estimating diastolic mechanical parameters of the left ventricle (LV) from cine and tagged MRI measurements and LV cavity pressure recordings, separating the passive myocardial constitutive properties and diastolic residual AT. Dynamic C1-continuous meshes are automatically built from the anatomy and deformation captured from dynamic MRI sequences. Diastolic deformation is simulated using a mechanical model that combines passive and active material properties. The problem of non-uniqueness of constitutive parameter estimation using the well known Guccione law is characterized by reformulation of this law. Using this reformulated form, and by constraining the constitutive parameters to be constant across time points during diastole, we separate the effects of passive constitutive properties and the residual AT during diastolic relaxation. Finally, the method is applied to two clinical cases and one control, demonstrating that increased residual AT during diastole provides a potential novel index for delineating healthy and pathological cases.
authors.affiliation: Department of Computer Science, University of Oxford, United Kingdom.
authors.forename: Jiahe
authors.initials: J
authors.lastname: Xi
authors.forename: Pablo
authors.initials: P
authors.lastname: Lamata
authors.forename: Steven
authors.initials: S
authors.lastname: Niederer
authors.forename: Sander
authors.initials: S
authors.lastname: Land
authors.forename: Wenzhe
authors.initials: W
authors.lastname: Shi
authors.forename: Xiahai
authors.initials: X
authors.lastname: Zhuang
authors.forename: Sebastien
authors.initials: S
authors.lastname: Ourselin
authors.forename: Simon G
authors.initials: SG
authors.lastname: Duckett
authors.forename: Anoop K
authors.initials: AK
authors.lastname: Shetty
authors.forename: C Aldo
authors.initials: CA
authors.lastname: Rinaldi
authors.forename: Daniel
authors.initials: D
authors.lastname: Rueckert
authors.forename: Reza
authors.initials: R
authors.lastname: Razavi
authors.forename: Nic P
authors.initials: NP
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D055119:Elastic Modulus; D006352:Heart Ventricles / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000503:physiopathology*