title: Contributions of Epstein-Barr nuclear antigen 1 (EBNA1) to cell immortalization and survival.
abstract: Epstein-Barr virus (EBV) immortalizes host cells as part of its latent mode of infection. As a result of this ability to promote cell proliferation and survival, EBV infection contributes to the development of several kinds of B-cell lymphomas and epithelial tumours. The EBV Epstein-Barr nuclear antigen 1 (EBNA1) protein is the only EBV protein expressed in all EBV-associated tumours and plays multiple important roles in EBV latency. In addition to its well-studied roles in viral DNA replication, segregation and transcriptional activation, several studies have identified roles of EBNA1 in manipulating cellular processes that result in reduced apoptosis and increased cell survival. This review discusses these cellular effects of EBNA1 and mechanisms by which they occur.
authors.affiliation: Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto, ON M5S 1A8, Canada.
authors.forename: Lori
authors.initials: L
authors.lastname: Frappier
mesh_terms: D049109:Cell Proliferation; D002470:Cell Survival; D002472:Cell Transformation, Viral; D019309:Epstein-Barr Virus Nuclear Antigens / Q000378:metabolism*; D004854:Herpesvirus 4, Human / Q000472:pathogenicity*; D006801:Humans; D015513:Oncogene Proteins; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D019309:Epstein-Barr Virus Nuclear Antigens; D015513:Oncogene Proteins; D037521:Virulence Factors; C417029:EBV-encoded nuclear antigen 1