title: Predictive and prognostic value of metabolic tumour volume and total lesion glycolysis in solid tumours.
abstract: Data available in patients suffering from squamous cell carcinoma of the head and neck, lung carcinoma, oesophageal carcinoma and gynaecological malignancies suggest that metabolic tumour volume and to a lesser extent total lesion glycolysis have the potential to become valuable in the imaging of human solid tumours as prognostic biomarkers for short- to intermediate-term survival outcomes, adding value to clinical staging, for assessment of response to treatment with neoadjuvant and concurrent chemotherapy, and for treatment optimization; for example, based on early treatment response assessment using changes in metabolic tumour volume over time, it might be possible to select patients who require a more aggressive treatment to improve their outcome. Prospective studies enrolling consecutive patients, adopting standardized protocols for FDG PET acquisition and processing, adjusting for potential confounders in the analysis (tumour size and origin) and determining the optimal methodology for determination of these novel markers are mandatory.
authors.affiliation: Department of Nuclear Medicine, P7, University Hospital Ghent, De Pintelaan 185-B, 9000 Ghent, Belgium. Christophe.vandewiele@ugent.be
authors.forename: Christophe
authors.initials: C
authors.lastname: Van de Wiele
authors.forename: Vibeke
authors.initials: V
authors.lastname: Kruse
authors.forename: Peter
authors.initials: P
authors.lastname: Smeets
authors.forename: Mike
authors.initials: M
authors.lastname: Sathekge
authors.forename: Alex
authors.initials: A
authors.lastname: Maes
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000494:pharmacology; D005833:Genital Neoplasms, Female / Q000175:diagnosis / Q000378:metabolism; D006019:Glycolysis / Q000502:physiology*; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism; D008297:Male; D008495:Medical Oncology / Q000379:methods; D009367:Neoplasm Staging / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D011237:Predictive Value of Tests; D011379:Prognosis; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D019788:Fluorodeoxyglucose F18