title: Phenylpropanoid-substituted procyanidins and tentatively identified procyanidin glycosides from hawthorn (Crataegus spp.).
abstract: The rational use of hawthorn leafs and flowers from Crataegus spp. for declining cardiac performance is mainly due to flavon-C-glycosides and oligomeric procyanidins (OPC). From OPC-enriched extracts from different batches, a dimeric phenylpropanoid-substituted procyanidin (cinchonain II b, 1) was isolated and characterized by MS, CD, and NMR. Also the presence of higher oligomeric cinchonains (degree of polymerization 3 to 8) in hawthorn extracts was shown by a specific ultrahigh-pressure liquid chromatography-ESI-qTOF-MS method. Interestingly, strong evidence for the occurrence of oligomeric procyanidin hexosides was found by ultrahigh-pressure liquid chromatography-ESI-qTOF-MS analysis which additionally revealed the presence of peaks indicative of dimeric procyanidin hexosides by their exact mass, which were clearly distinguishable from the cinchonain II type peaks.
authors.affiliation: University of Münster, Institute of Pharmaceutical Biology and Phytochemistry, Münster, Deutschland.
authors.forename: Jandirk
authors.initials: J
authors.lastname: Sendker
authors.forename: Frank
authors.initials: F
authors.lastname: Petereit
authors.forename: Marcus
authors.initials: M
authors.lastname: Lautenschläger
authors.forename: Nils
authors.initials: N
authors.lastname: Hellenbrand
authors.forename: Andreas
authors.initials: A
authors.lastname: Hensel
mesh_terms: D002853:Chromatography, Liquid; D027825:Crataegus / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification*; D018515:Plant Leaves / Q000737:chemistry; D044945:Proanthocyanidins / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D006027:Glycosides; D010936:Plant Extracts; D044945:Proanthocyanidins