title: Amyloid toxicity and platelet-activating factor signaling.
abstract: Amyloidosis is the accumulation of insoluble proteinaceous aggregates in vivo and is implicated in many neurodegenerative diseases, including Alzheimer's, Huntington's, and Parkinson's diseases. This article briefly reviews the current knowledge of amyloid aggregate toxicity and inflammatory signaling in the nervous system. In particular, we focus our attention on the role of platelet-activating factor (PAF) as mediator of amyloid cytotoxicity.
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
authors.forename: Ivana
authors.initials: I
authors.lastname: Sirangelo
authors.forename: Gaetano
authors.initials: G
authors.lastname: Irace
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Balestrieri
mesh_terms: D000682:Amyloid / Q000378:metabolism* / Q000633:toxicity; D000686:Amyloidosis / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress; D010972:Platelet Activating Factor / Q000378:metabolism*; D055503:Protein Multimerization; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000682:Amyloid; D018836:Inflammation Mediators; D018696:Neuroprotective Agents; D010972:Platelet Activating Factor