title: Basal ganglia-cortical interactions in Parkinsonian patients.
abstract: Parkinson's disease is a common and debilitating condition, caused by aberrant activity in a complex basal ganglia-thalamocortical circuit. Therapeutic advances rely on characterising interactions in this circuit. However, recording electrophysiological responses over the entire circuit is impractical. Dynamic causal modelling offers large-scale models of predictive value based on a limited or partial sampling of complex networks. Using dynamic causal modelling, we determined the network changes underlying the pathological excess of beta oscillations that characterise the Parkinsonian state. We modelled data from five patients undergoing surgery for deep brain stimulation of more than one target. We found that connections to and from the subthalamic nucleus were strengthened and promoted beta synchrony, in the untreated compared to the treated Parkinsonian state. Dynamic causal modelling was able to replicate the effects of lesioning this nucleus and may provide a new means of directing the search for therapeutic targets.
authors.affiliation: Nuffield Department of Clinical Neurology, University of Oxford, UK; Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, UK.
authors.forename: André C
authors.initials: AC
authors.lastname: Marreiros
authors.affiliation: Nuffield Department of Clinical Neurology, University of Oxford, UK.
authors.forename: Hayriye
authors.initials: H
authors.lastname: Cagnan
authors.affiliation: The Wellcome Trust Centre for Neuroimaging, University College London, UK.
authors.forename: Rosalyn J
authors.initials: RJ
authors.lastname: Moran
authors.affiliation: The Wellcome Trust Centre for Neuroimaging, University College London, UK.
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Friston
authors.affiliation: Nuffield Department of Clinical Neurology, University of Oxford, UK. Electronic address: peter.brown@ndcn.ox.ac.uk.
authors.forename: Peter
authors.initials: P
authors.lastname: Brown
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D046690:Deep Brain Stimulation; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology*; D020531:Subthalamic Nucleus / Q000503:physiopathology