title: Idiopathic ileocolitis with perforation associated with HIV infection: thalidomide treatment.
abstract: Idiopathic cutaneous ulcers, oesophageal ulcers and severe ulcerative ileocolitis occurred in a human immunodeficiency virus (HIV)-infected patient early after the initiation of combination antiretroviral therapy. This massive inflammatory process led to acute colonic perforation on two occasions. The disease was refractory to standard therapy, but responded successfully to thalidomide. Here, we discuss the potential benefits of thalidomide in refractory inflammatory processes in HIV-infected patients.
authors.affiliation: Infectious Diseases Unit, Hospital General Universitario de Elche, Camí de la Almazara 11, 03203 Elche. jramosrincon@yahoo.es
authors.forename: J M
authors.initials: JM
authors.lastname: Ramos
authors.forename: M
authors.initials: M
authors.lastname: Masiá
authors.forename: R
authors.initials: R
authors.lastname: Durán
authors.forename: F
authors.initials: F
authors.lastname: Gutiérrez
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007416:Intestinal Perforation / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D013792:Thalidomide / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D013792:Thalidomide