title: You don't say: dynamic aphasia, another variant of primary progressive aphasia?
abstract: Primary progressive aphasia (PPA) is a language predominant neurodegenerative disorder that has three recognized variants: nonfluent/agrammatic, semantic, and logopenic. This report describes a 60-year-old man who presented with a progressive decline in verbal output that does not fit the currently accepted PPA subtypes. The patient exhibited a paucity of verbal output and impaired phonemic fluency with minimal associated language, cognitive, or behavioral deficits. Focal cortical thinning/hypometabolism of the left superior frontal region and a cerebrospinal fluid profile not consistent with Alzheimer's disease pathology were identified. This case of isolated progressive dynamic aphasia extends the current boundaries of PPA diagnostic variants.
authors.affiliation: Department of Neurology, Center for Brain/Mind Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Perez
authors.forename: Bradford C
authors.initials: BC
authors.lastname: Dickerson
authors.forename: Scott M
authors.initials: SM
authors.lastname: McGinnis
authors.forename: Daisy
authors.initials: D
authors.lastname: Sapolsky
authors.forename: Keith
authors.initials: K
authors.lastname: Johnson
authors.forename: Meghan
authors.initials: M
authors.lastname: Searl
authors.forename: Kirk R
authors.initials: KR
authors.lastname: Daffner
mesh_terms: D018888:Aphasia, Primary Progressive / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000503:physiopathology*; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007802:Language; D007807:Language Tests; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D009483:Neuropsychological Tests