title: Comparative study between the effect of methotrexate and valproic acid on solid Ehrlich tumour.
abstract: BACKGROUND
  SEC is an undifferentiated tumour used in tumour studies. MTX is an antimetabolite used in treatment of cancer, autoimmune diseases and induction of abortion. VPA is used as anticonvulsant and is under investigation for treatment of cancer. The aim of this work was to compare between the effect of each of MTX and VPA on solid Ehrlich tumour in mice.
  
  
  METHODS
  Forty albino mice were divided into 4 equal groups: control untreated group, SEC group, SEC+MTX group, and SEC+VPA group. Tumour volume, tissue CAT, tissue GR, tissue MDA, tissue cholesterol and tissue TNF-α were determined. A part of the tumour was examined for histopathological and immunohistochemical study.
  
  
  RESULTS
  MTX alone or VPA alone induced a significant increase in tissue CAT and GR with a significant decrease in the tumour volume, tissue MDA, cholesterol and TNF-α and alleviated the histopathological changes with a significant increase in p53 expression compared to SEC group. This effect was more significant in MTX treated group compared to VPA treated group.
  
  
  CONCLUSIONS
  MTX has more antitumour effect than VPA against SEC.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt. drakabel@gmail.com
authors.forename: Mohamed Nabih
authors.initials: MN
authors.lastname: Abdel-Rahman
authors.forename: Ahmed Mohammed
authors.initials: AM
authors.lastname: Kabel
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D002374:Catalase / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D005979:Glutathione Peroxidase / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D009368:Neoplasm Transplantation; D047368:Tumor Burden / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014635:Valproic Acid / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D014409:Tumor Necrosis Factor-alpha; D016159:Tumor Suppressor Protein p53; D008315:Malondialdehyde; D014635:Valproic Acid; D002784:Cholesterol; D002374:Catalase; D005979:Glutathione Peroxidase; D008727:Methotrexate