title: [Metabolic syndrome and microalbuminuria accompanied with hyperglycemia in community subjects].
abstract: OBJECTIVE
  To examine the prevalence of metabolic syndrome (MS) and microalbuminuria (MAU) in subjects with different levels of glucose tolerance and probe the risk factors for the development of MAU.
  
  
  METHODS
  A total of 951 subjects were divided into 3 groups according to the results of oral glucose tolerance test (OGTT). Among them, there were 674 subjects with normal glucose tolerance (NGT), 195 with impaired glucose regulation (IGR) and 82 newly-diagnosed cases of type 2 diabetes mellitus (T2DM). MAU was diagnosed if urine albumin-to-creatinine ratio (UACR) was 30 - 300 mg/g.
  
  
  RESULTS
  (1) Compared to the NGT subjects, both the IGR and newly-diagnosed T2DM subjects had the significantly higher levels of age, body mass index (BMI), waist circumference, fasting plasma glucose, 2-hour post OGTT glucose (2 hPG), glycated hemoglobin, glycated albumin, fasting insulin, homeostasis model of assessment-insulin resistance (HOMA-IR), triglyceride, systolic blood pressure (SBP) and UACR but a lower level of high density lipoprotein-cholesterol (HDL-C); (2) The incident rate of MS and MAU in the IGR and newly-diagnosed T2DM subjects was 54.4% (106/195), 12.3% (24/195) and 61.0% (50/82), 12.2% (10/82) respectively versus 9.1% (61/674) and 4.9% (33/674) in the NGT subjects. The incident rate of abdominal obesity, hypertension, hypertriglyceridemia, low HDL-C, MS and MAU in the IGR and newly-diagnosed T2DM subjects was significantly higher than that of the NGT subjects (all P < 0.05); (3) Multiple regression analysis showed that BMI, SBP and 2 hPG were independently associated with UACR. Logistic regression analysis indicated that BMI, SBP and 2 hPG were independent risk factors of MAU.
  
  
  CONCLUSIONS
  The prevalence of MS and MAU is significantly higher in the IGR and newly-diagnosed T2DM subjects. BMI, SBP and 2 hPG are independent risk factors of MAU.
authors.affiliation: Gonghexin Community Health Service Center, Shanghai, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Fei-fei
authors.initials: FF
authors.lastname: Wang
authors.forename: Xiao-jian
authors.initials: XJ
authors.lastname: Zhu
authors.forename: Jun-jing
authors.initials: JJ
authors.lastname: Luo
authors.forename: Yan
authors.initials: Y
authors.lastname: Han
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Pan
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiao-jing
authors.initials: XJ
authors.lastname: Ma
authors.forename: Yu-qian
authors.initials: YQ
authors.lastname: Bao
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Jia
mesh_terms: D000419:Albuminuria / Q000453:epidemiology*; D001786:Blood Glucose / Q000378:metabolism; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology*; D005260:Female; D018149:Glucose Intolerance; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
chemical_list: D001786:Blood Glucose