title: Prominin-1 (CD133) and Metastatic Melanoma: Current Knowledge and Therapeutic Perspectives.
abstract: Innovative approaches to specifically target the melanoma subpopulation responsible for local invasion and metastatic dissemination are needed. Prominin-1 (CD133) expression has been observed in many melanoma cell lines, as well as in primary and metastatic melanomas from patients. Although its function(s) in melanoma is presently unknown, prominin-1 may represent a molecular target, due to its association with melanoma stem cells and with the metastatic phenotype.
authors.affiliation: Cancer Research Program, Roseman University of Health Sciences, 89104, Henderson, NV, USA, alorico@roseman.edu.
authors.forename: Aurelio
authors.initials: A
authors.lastname: Lorico
authors.forename: Javier
authors.initials: J
authors.lastname: Mercapide
authors.forename: Germana
authors.initials: G
authors.lastname: Rappa
mesh_terms: D006801:Humans; D008545:Melanoma