title: Successful liver transplantation in an infant with stage 4S(M) neuroblastoma.
abstract: We report a 2.5-month-old infant with bilateral adrenal neuroblastoma, stage 4S(M), with liver metastases and chemotherapy-induced veno-occlusive disease leading to cirrhosis requiring liver transplantation. Despite unknown tumour histology and MYCN-amplification status, we proceeded with liver transplant. This decision was based on clinical suspicion that our patient was MYCN-negative due to significant tumour regression, and was supported by evidence indicating that MYCN-amplification is rare in infants with favourable-stage neuroblastoma. This is the second case report of neuroblastoma requiring liver transplantation; however, in the previously reported case, the diagnosis of neuroblastoma was not established until after transplantation. We discuss this unique case to justify the potential use of life-saving liver transplants in infants with neuroblastoma.
authors.affiliation: McMaster University, Michael G. DeGroote School of Medicine, Hamilton, Canada.
authors.forename: Melanie
authors.initials: M
authors.lastname: Steele
authors.forename: Nicola L
authors.initials: NL
authors.lastname: Jones
authors.forename: Vicky
authors.initials: V
authors.lastname: Ng
authors.forename: Binita
authors.initials: B
authors.lastname: Kamath
authors.forename: Yaron
authors.initials: Y
authors.lastname: Avitzur
authors.forename: Rose
authors.initials: R
authors.lastname: Chami
authors.forename: Ernest
authors.initials: E
authors.lastname: Cutz
authors.forename: Annie
authors.initials: A
authors.lastname: Fecteau
authors.forename: Sylvain
authors.initials: S
authors.lastname: Baruchel
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery; D016031:Liver Transplantation; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000556:secondary* / Q000601:surgery*