title: Abdominal compartment syndrome and acute kidney injury due to excessive auto-positive end-expiratory pressure.
abstract: Abdominal compartment syndrome is an under-recognized cause of acute kidney injury in critically ill patients. We report a case of a patient with severe obstructive lung disease who, while intubated for respiratory failure, developed abdominal compartment syndrome and oliguric acute kidney injury due to air-trapping and excessive auto-positive end-expiratory pressure (auto-PEEP; also known as intrinsic PEEP). When chemical paralysis was initiated and the auto-PEEP resolved, the patient's intra-abdominal hypertension rapidly improved and kidney function recovered immediately. Abdominal compartment syndrome secondary to excessive auto-PEEP appears to be unreported in the literature; however, any process that significantly increases intrathoracic pressure conceivably could cause increased pressure to be transmitted to the abdominal compartment, resulting in organ failure. Patients undergoing mechanical ventilation, which puts them at risk of airflow obstruction and the development of intra-abdominal hypertension, should be evaluated for air-trapping and excessive auto-PEEP.
authors.affiliation: Division of Nephrology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. dwight.matthew@drexelmed.edu
authors.forename: Dwight
authors.initials: D
authors.lastname: Matthew
authors.forename: David
authors.initials: D
authors.lastname: Oxman
authors.forename: Karim
authors.initials: K
authors.lastname: Djekidel
authors.forename: Ziauddin
authors.initials: Z
authors.lastname: Ahmed
authors.forename: Michael
authors.initials: M
authors.lastname: Sherman
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D006801:Humans; D059325:Intra-Abdominal Hypertension / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration / Q000009:adverse effects*