title: Penumbral imaging by using perfusion computed tomography and perfusion-weighted magnetic resonance imaging: current concepts.
abstract: Perfusion computed tomography and perfusion-weighted magnetic resonance imaging are used to evaluate the extent of the area with ischemic penumbra; however, different parameters, algorithms, and software packages show significant discrepancies in the size of perfusion abnormalities, which should be minimized. Recently, cross-validation studies were performed using digital phantoms and have elucidated the precision and reliability of various penumbral imaging techniques. These research initiatives can promote further multicenter trials on recanalization therapies by providing accurate inclusion/exclusion criteria for appropriate patient selection.
authors.affiliation: Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Nishitokuta, Yahaba, Japan. Electronic address: masasaki@iwate-med.ac.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Kudo
authors.forename: Soren
authors.initials: S
authors.lastname: Christensen
authors.forename: Fumio
authors.initials: F
authors.lastname: Yamashita
authors.forename: Jonathan
authors.initials: J
authors.lastname: Goodwin
authors.forename: Satomi
authors.initials: S
authors.lastname: Higuchi
authors.forename: Akira
authors.initials: A
authors.lastname: Ogawa
mesh_terms: D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods*; D020521:Stroke / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*