title: Broadband continuous-wave technique to measure baseline values and changes in the tissue chromophore concentrations.
abstract: We present a broad-band, continuous-wave spectral approach to quantify the baseline optical properties of tissue and changes in the concentration of a chromophore, which can assist to quantify the regional blood flow from dynamic contrast-enhanced near-infrared spectroscopy data. Experiments were conducted on phantoms and piglets. The baseline optical properties of tissue were determined by a multi-parameter wavelength-dependent data fit of a photon diffusion equation solution for a homogeneous medium. These baseline optical properties were used to find the changes in Indocyanine green concentration time course in the tissue. The changes were obtained by fitting the dynamic data at the peak wavelength of the chromophore absorption, which were used later to estimate the cerebral blood flow using a bolus tracking method.
authors.affiliation: Ryerson University, Department of Physics, 350 Victoria St. Toronto, Ontario M5B 2K3,  Canada.
authors.forename: Hadi Zabihi
authors.initials: HZ
authors.lastname: Yeganeh
authors.forename: Vladislav
authors.initials: V
authors.lastname: Toronov
authors.forename: Jonathan T
authors.initials: JT
authors.lastname: Elliott
authors.forename: Mamadou
authors.initials: M
authors.lastname: Diop
authors.forename: Ting-Yim
authors.initials: TY
authors.lastname: Lee
authors.forename: Keith
authors.initials: K
authors.lastname: St Lawrence