title: Anhelation due to formation of tuberculomas at the medulla oblongata during chemotherapy of tuberculous meningitis.
abstract: Formation of tuberculoma is a rare response of neurotuberculosis in patients regularly and adequately treated with anti-tuberculous drugs. We report a 13-year-old girl with two tuberculomas which formed in the dorsal part of the medulla oblongata during chemotherapy for tuberculous meningitis. The tuberculomas were both removed via a suboccipital midline approach and were demonstrated by pathological findings but the girl died of cardiac arrest that was thought to be caused by postoperative medulla oblongata oedema. In combination with a literature review, we discuss the clinical features and treatment options of brainstem tuberculomas.
authors.affiliation: 1st Bethune Hospital of Jilin University, 71 Xinmin Street, 130021 Changchun, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Ge
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Zhang
authors.forename: Yangping
authors.initials: Y
authors.lastname: Zhong
authors.forename: Xinchao
authors.initials: X
authors.lastname: Bian
authors.forename: Shuanglin
authors.initials: S
authors.lastname: Fu
authors.forename: Yinan
authors.initials: Y
authors.lastname: Luo
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology*; D001929:Brain Edema / Q000209:etiology; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D006323:Heart Arrest / Q000209:etiology; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage; D008526:Medulla Oblongata / Q000473:pathology / Q000601:surgery; D011718:Pyrazinamide / Q000008:administration & dosage; D012293:Rifampin / Q000008:administration & dosage; D014375:Tuberculoma / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D014390:Tuberculosis, Meningeal / Q000150:complications / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin