title: [Study on synthesis on a novel nano-antibacterial inorganic filler and its antibacterial property].
abstract: OBJECTIVE
  To synthesize a novel nano-antibacterial inorganic filler and provide a new way to give dental composite resin antibacterial property.
  
  
  METHODS
  Quaternary ammonium iodide N,N,N-trimethyl-3-(trimethoxysilyl) propan-1-aminium iodide were organically synthesized firstly and then the N,N,N-trimethyl-3-(trimethoxysilyl) propan-1-aminium iodide was grafted to the nano-silica particle to synthesize the antihacterial inorganic fillers nano-silica particle grafted with quaternary ammonium salt. All the products were analyzed and identified by infrared spectrum analysis. Then Streptococcus mutans were chosen as experimental object to analysis the antibacterial property of nanoantibacterial inorganic filler.
  
  
  RESULTS
  Quaternary ammonium salt was grafted to the surface of nano-silica particles successfully by infrared spectrum analysis. Compared with the control group, the nano-silica particle grafted with quaternary ammonium salt had a strong bactericidal effect on Streptococcus mutons (P < 0.01).
  
  
  CONCLUSIONS
  The nano-silica particle grafted with quaternary ammonium salt has a strong antibacterial property and could be used to improve dental composite resin antibacterial property.
authors.affiliation: Dept. of Prosthodontics, College of Stomatology, Shandong University, Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan 250012, China.
authors.forename: Junling
authors.initials: J
authors.lastname: Wu
authors.forename: Chanyuan
authors.initials: C
authors.lastname: Jin
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Nie
authors.forename: Kaiyun
authors.initials: K
authors.lastname: Zhou
authors.forename: Chuanjian
authors.initials: C
authors.lastname: Zhou
mesh_terms: D000180:Acrylic Resins; D064751:Ammonium Compounds; D000900:Anti-Bacterial Agents; D003188:Composite Resins; D011140:Polyurethanes; D000644:Quaternary Ammonium Compounds; D012822:Silicon Dioxide; D013295:Streptococcus mutans
chemical_list: D000180:Acrylic Resins; D064751:Ammonium Compounds; D000900:Anti-Bacterial Agents; C029012:Composite Dental Resin; D003188:Composite Resins; D011140:Polyurethanes; D000644:Quaternary Ammonium Compounds; D012822:Silicon Dioxide; C582942:ammonium iodide