title: A new ascochlorin derivative from Cylindrocarpon sp. FKI-4602.
abstract: Cylindrol A₅, a new ascochlorin congener, was isolated along with 14 known compounds from the culture broth of Cylindrocarpon sp. FKI-4602 by solvent extraction, octadecylsilane column chromatography and HPLC. The structure of cylindrol A₅ was elucidated by spectral analyses, including NMR. The compound has an ascochlorin skeleton consisting of a resorcin aldehyde and a cyclohexanone moieties. Cylindrol A₅ showed moderate antimicrobial activity against Bacillus subtilis, Kocuria rhizophila, Mycobacterium smegmatis and Acholeplasma laidlawii. The biosynthetic pathway to cylindrol A₅ was deduced from the 14 isolated metabolites of the fungal strain.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Mio
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuda
authors.forename: Ryuji
authors.initials: R
authors.lastname: Uchida
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nonaka
authors.forename: Rokuro
authors.initials: R
authors.lastname: Masuma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
mesh_terms: D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000475:Alkenes; D000900:Anti-Bacterial Agents; D003470:Culture Media; D010636:Phenols; C415745:ascochlorin