title: The biological fate of silver ions following the use of silver-containing wound care products - a review.
abstract: Ionic silver has a long history as an antimicrobial in human health care. This article is a review of the published literature on how ionic silver may enter the body from exposure to silver-containing wound care products and its eventual metabolic fates, in an assessment of the safety during normal use of these products in wound care. Following the application to breached skin, there appears to be little evidence of localised or systemic toxicity, and this is borne out by the continuous use of silver sulfadiazine formulations for more than 50 years. Consequently, following normal use, the risk of silver ion toxicity locally and systemically is considered to be low or negligible.
authors.affiliation: ConvaTec Global Development Centre, Deeside, Flintshire, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Walker
authors.forename: David
authors.initials: D
authors.lastname: Parsons
mesh_terms: D000891:Anti-Infective Agents, Local / Q000493:pharmacokinetics* / Q000627:therapeutic use* / Q000633:toxicity; D001458:Bandages; D006801:Humans; D018570:Risk Assessment; D018030:Silver Compounds / Q000493:pharmacokinetics* / Q000627:therapeutic use* / Q000633:toxicity; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*
chemical_list: D000891:Anti-Infective Agents, Local; D018030:Silver Compounds