title: [Related issues in clinical translational application of adipose-derived stem cells].
abstract: OBJECTIVE
  To introduce the related issues in the clinical translational application of adipose-derived stem cells (ASCs).
  
  
  METHODS
  The latest papers were extensively reviewed, concerning the issues of ASCs production, management, transportation, use, and safety during clinical application.
  
  
  RESULTS
  ASCs, as a new member of adult stem cells family, bring to wide application prospect in the field of regenerative medicine. Over 40 clinical trials using ASCs conducted in 15 countries have been registered on the website (http://www.clinicaltrials.gov) of the National Institutes of Health (NIH), suggesting that ASCs represents a promising approach to future cell-based therapies. In the clinical translational application, the related issues included the quality control standard that management and production should follow, the prevention measures of pathogenic microorganism pollution, the requirements of enzymes and related reagent in separation process, possible effect of donor site, age, and sex in sampling, low temperature storage, product transportation, and safety.
  
  
  CONCLUSIONS
  ASCs have the advantage of clinical translational application, much attention should be paid to these issues in clinical application to accelerate the clinical translation process.
authors.affiliation: Department of Plastic Surgery, First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine, Ministry of Education, Guangzhou Guangdong 510630, PR China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
authors.forename: Biao
authors.initials: B
authors.lastname: Cheng
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Fu
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D053687:Adult Stem Cells / Q000166:cytology; D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control*; D002454:Cell Differentiation; D002469:Cell Separation / Q000379:methods*; D002478:Cells, Cultured; D006801:Humans; D011786:Quality Control; D012015:Reference Standards; D044968:Regenerative Medicine / Q000379:methods*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering; D057170:Translational Research, Biomedical