title: [Diagnostic value of (18)F-labeled NaF positron emission tomography-computed tomography imaging in the detection of bone metastases in patients with lung cancer before treatment].
abstract: OBJECTIVE
  To evaluate the diagnostic values of (18)F-sodium fluoride ((18)F-NaF) positron emission tomography/computed tomography (PET/CT) imaging in the detection of bone metastases of lung cancer.
  
  
  METHODS
  A total of 107 lung cancer patients were diagnosed by histopathology and undergone (18)F-NaF PET-CT imaging.
  
  
  RESULTS
  Among them, the histopathologically diagnosed tumors included adenocarcinoma (n = 47), squamous cell carcinoma (n = 19), small cell lung cancer (n = 4) and other malignant types (n = 34). Bone metastases occurred in adenocarcinoma (n = 19) and squamous cell carcinoma (n = 4).(18)F-NaF PET/CT imaging had a high sensitivity of 100% in the diagnosis of bone metastases with malignant lung tumors. And its specificity was 98.7%, accuracy 99% and positive predictive value 97.0%.
  
  
  CONCLUSIONS
  (18)F-NaF PET-CT imaging can detect the bone metastases of lung cancer preoperatively with a high level of sensitivity and accuracy.
authors.affiliation: Department of Nuclear Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Wang
authors.forename: Liang-jun
authors.initials: LJ
authors.lastname: Rao
authors.forename: Bing-qi
authors.initials: BQ
authors.lastname: Luo
authors.forename: Zhi-feng
authors.initials: ZF
authors.lastname: Chen
authors.forename: Xiang-song
authors.initials: XS
authors.lastname: Zhang
authors.forename: Xin-chong
authors.initials: XC
authors.lastname: Shi
authors.forename: Chang
authors.initials: C
authors.lastname: Yi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000556:secondary; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18