title: Differential progressive remodeling of coronary and cerebral arteries and arterioles in an aortic coarctation model of hypertension.
abstract: OBJECTIVE
  Effects of hypertension on arteries and arterioles often manifest first as a thickened wall, with associated changes in passive material properties (e.g., stiffness) or function (e.g., cellular phenotype, synthesis and removal rates, and vasomotor responsiveness). Less is known, however, regarding the relative evolution of such changes in vessels from different vascular beds.
  
  
  METHODS
  We used an aortic coarctation model of hypertension in the mini-pig to elucidate spatiotemporal changes in geometry and wall composition (including layer-specific thicknesses as well as presence of collagen, elastin, smooth muscle, endothelial, macrophage, and hematopoietic cells) in three different arterial beds, specifically aortic, cerebral, and coronary, and vasodilator function in two different arteriolar beds, the cerebral and coronary.
  
  
  RESULTS
  Marked geometric and structural changes occurred in the thoracic aorta and left anterior descending coronary artery within 2 weeks of the establishment of hypertension and continued to increase over the 8-week study period. In contrast, no significant changes were observed in the middle cerebral arteries from the same animals. Consistent with these differential findings at the arterial level, we also found a diminished nitric oxide-mediated dilation to adenosine at 8 weeks of hypertension in coronary arterioles, but not cerebral arterioles.
  
  
  CONCLUSIONS
  These findings, coupled with the observation that temporal changes in wall constituents and the presence of macrophages differed significantly between the thoracic aorta and coronary arteries, confirm a strong differential progressive remodeling within different vascular beds. Taken together, these results suggest a spatiotemporal progression of vascular remodeling, beginning first in large elastic arteries and delayed in distal vessels.
authors.affiliation: Department of Biomedical Engineering, Texas A&M University TX, USA.
authors.forename: H N
authors.initials: HN
authors.lastname: Hayenga
authors.forename: J-J
authors.initials: JJ
authors.lastname: Hu
authors.forename: C A
authors.initials: CA
authors.lastname: Meyer
authors.forename: E
authors.initials: E
authors.lastname: Wilson
authors.forename: T W
authors.initials: TW
authors.lastname: Hein
authors.forename: L
authors.initials: L
authors.lastname: Kuo
authors.forename: J D
authors.initials: JD
authors.lastname: Humphrey