title: Multiple organ dysfunction: a delayed envenomation syndrome caused by tentacle extract from the jellyfish Cyanea capillata.
abstract: The delayed jellyfish envenomation syndrome (DJES) with serious multiple organ dysfunction or systemic damages, generally developed 2 h after jellyfish stings, deserves special attention for it is very meaningful to the clinical interventions. To set up a DJES model as well as to obtain more details about its process, an integrative approach, including clinical chemistry, pathology and immunohistochemistry, was conducted to simultaneously monitor the effects of tentacle extract (TE) from the jellyfish Cyanea capillata on the vital target organs (heart, lung, liver and kidney). Our results showed that the TE from C. capillata could induce diverse toxic effects on these organs, among which the liver and kidney injuries seemed to be more serious than cardiopulmonary injuries and might be the leading causes of death in rats with DJES. In summary, we have established a DJES model with multiple organ dysfunction, which could facilitate the research on its underlying mechanism as well as the development of specific prevention or therapy strategies against jellyfish envenomation. The application of this model suggested that the possible mechanism of DJES might be attributed to the synergy of cytotoxicity, vasoconstriction effect and other specific target organ toxicities of jellyfish venom.
authors.affiliation: Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
authors.forename: Beilei
authors.initials: B
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Jiemin
authors.initials: J
authors.lastname: Zheng
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Jia
authors.initials: J
authors.lastname: Lu
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Wen
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Guoyan
authors.initials: G
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Xiao
authors.forename: Liming
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000187:drug effects; D003064:Cnidarian Venoms / Q000633:toxicity*; D004195:Disease Models, Animal; D004573:Electrolytes / Q000097:blood; D007150:Immunohistochemistry; D007928:Lethal Dose 50; D008297:Male; D046529:Microscopy, Electron, Transmission; D009102:Multiple Organ Failure / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014020:Tissue Extracts / Q000633:toxicity
chemical_list: D003064:Cnidarian Venoms; D004573:Electrolytes; D014020:Tissue Extracts