title: High expression levels of COX-2 and P300 are associated with unfavorable survival in laryngeal squamous cell carcinoma.
abstract: In order to provide a basis for clinical treatment decisions, we explored whether there was a correlation between the expression of COX-2 and P300 and clinical factors in a group of patients with laryngeal squamous cell carcinoma (LSCC). A retrospective analysis of clinicopathological data was conducted in 80 patients with LSCC who presented between January 1997 and December 1998. An immunohistochemistry tissue microarray was conducted of 80 surgically resected LSCC and 20 adjacent normal tissue specimens. Survival analysis and Kaplan-Meier curves were used to compare the effects of clinicopathological factors on survival. The Cox model was applied for multivariate analysis. The expression level of COX-2/P300 in LSCC tissues and adjacent normal tissues were 47.5/50.0 versus 0.0/15.0 %. The expression of COX-2 and P300 was correlated with higher T category, N category, clinical staging, histological grade and recurrence (P < 0.05). P300 expression was correlated with COX-2 expression (P < 0.05). Univariate survival analysis showed that P300, COX-2, N category, clinical staging and recurrence factors were closely correlated with unfavorable survival (P < 0.05). Multivariate analysis showed that COX-2 expression, histological grade and recurrence were independent prognostic factors for LSCC. High expression levels of COX-2 and P300 indicated poor survival outcomes for patients with LSCC.
authors.affiliation: State Key Laboratory of Oncology in South China, Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China. chenyf@sysucc.org.cn
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Chen
authors.forename: Rong-Zhen
authors.initials: RZ
authors.lastname: Luo
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Bo-Kang
authors.initials: BK
authors.lastname: Cui
authors.forename: Ming
authors.initials: M
authors.lastname: Song
authors.forename: An-Kui
authors.initials: AK
authors.lastname: Yang
authors.forename: Wen-Kuan
authors.initials: WK
authors.lastname: Chen
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D050881:E1A-Associated p300 Protein / Q000378:metabolism*; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D046888:Tissue Array Analysis
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D050881:E1A-Associated p300 Protein; C494360:EP300 protein, human