title: Bioactive constituents of Homalomena aromatica essential oil and its antifungal activity against dermatophytes and yeasts.
abstract: Homalomena aromatica rhizomes are rich source of essential oils, which have been attributed for various medicinal uses. In the present investigation, essential oil from H. aromatica rhizomes was isolated and subjected to gas chromatography-mass spectrum (GC-MS) analysis. Fifty-five chemical constituents were reported from H. aromatica rhizomes of which T-muurolol (5.32%), viridiflorol (3.69%), α-selinene (2.19%), M-cymene (2.19%) and γ-Muurolene (1.81%) were identified and reported for the first time. Other major components were identified as linalool (62.5%), terpene-4-ol (7.08%), δ-cadinene (5.57%), α-cadinol (3.71%) and spatulenol (1.81%). H. aromatica rhizome essential oil showed high antimicrobial activity against Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum fulvum, Microsporum gypseum, Trichosporon beigelii and Candida albicans.
authors.affiliation: Defence Research Laboratory, Tezpur 784001, Assam, India. poligene@rediffmail.com
authors.forename: R S
authors.initials: RS
authors.lastname: Policegoudra
authors.forename: S
authors.initials: S
authors.lastname: Goswami
authors.forename: S M
authors.initials: SM
authors.lastname: Aradhya
authors.forename: S
authors.initials: S
authors.lastname: Chatterjee
authors.forename: S
authors.initials: S
authors.lastname: Datta
authors.forename: R
authors.initials: R
authors.lastname: Sivaswamy
authors.forename: P
authors.initials: P
authors.lastname: Chattopadhyay
authors.forename: L
authors.initials: L
authors.lastname: Singh
mesh_terms: D000080462:Acyclic Monoterpenes; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D001688:Biological Products / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000302:isolation & purification / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects
chemical_list: D000080462:Acyclic Monoterpenes; D000935:Antifungal Agents; D001688:Biological Products; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; D012717:Sesquiterpenes; C499351:T-muurolol; D013729:Terpenes; C445364:cadinol; C539285:selinene; C018584:linalool; C552080:viridiflorol