title: Borderline sebaceous neoplasm in a renal transplant patient without Muir-Torre syndrome.
abstract: Borderline sebaceous neoplasms are rare tumors that can be challenging to diagnose because of their admixture of histopathologic features. Most such tumors have been described in patients with Muir-Torre syndrome (MTS). We report the case of an immunosuppressed, 82-year-old African-American woman without MTS who developed a rapidly growing lesion on the left cheek. Histopathology revealed a borderline sebaceous neoplasm with predominant features of sebaceous adenoma and with focal features raising concern for the possibility of an evolving, well-differentiated, low-grade sebaceous carcinoma with a high mitotic index. In the setting of immunosuppression, borderline sebaceous neoplasms may occur outside of MTS; careful evaluation and conservative treatment are recommended in managing such tumors.
authors.affiliation: Section of Dermatology, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA.
authors.forename: Edidiong C N
authors.initials: EC
authors.lastname: Kaminska
authors.forename: Vivek
authors.initials: V
authors.lastname: Iyengar
authors.forename: Maria
authors.initials: M
authors.lastname: Tsoukas
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Shea
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000523:psychology; D000369:Aged, 80 and over; D005153:Facial Neoplasms / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D055653:Muir-Torre Syndrome; D012626:Sebaceous Gland Neoplasms / Q000378:metabolism / Q000473:pathology