title: The botryoidal microcapsule: a novel tissue scaffold.
abstract: OBJECTIVE
  Due to the semi-permeable membrane and biocompatibility, microcapsules have a very promising future in cell transplantation, drug carrier and large-scale cell culture. However, the current design prevents it from playing a role in tissue scaffold.
  
  
  METHODS
  To address this pitfall, we invented a self-assembled botryoidal microcapsule by means of electrostatic interactions. The diameter of the scaffold was adjustable between 1 and 5cm, while that of the standard microcapsule is ordinarily 500µm.
  
  
  RESULTS
  Tests showed that it had better mechanical strength, as well as characteristics of biocompatibility and permeability.
  
  
  CONCLUSIONS
  A botryoidal microcapsule is also effective at blocking the entrance of IgG and has the potential to function both as a favorable carrier and as a scaffold for artificial organs.
authors.affiliation: Department of General Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Dong
authors.forename: Long
authors.initials: L
authors.lastname: Cui
authors.forename: Chenghong
authors.initials: C
authors.lastname: Peng
authors.forename: Baosan
authors.initials: B
authors.lastname: Han
authors.forename: Fang
authors.initials: F
authors.lastname: Huang
mesh_terms: D000418:Albumins / Q000378:metabolism; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials; D015415:Biomarkers / Q000378:metabolism; D002214:Capsules; D002478:Cells, Cultured; D048271:Chitosan / Q000031:analogs & derivatives / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D022781:Hepatocytes / Q000378:metabolism; D006603:Hexuronic Acids / Q000737:chemistry; D007074:Immunoglobulin G / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010539:Permeability; D055672:Static Electricity; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D000418:Albumins; D000464:Alginates; D001672:Biocompatible Materials; D015415:Biomarkers; D002214:Capsules; D006603:Hexuronic Acids; D007074:Immunoglobulin G; D020723:Glucuronic Acid; D048271:Chitosan; D007770:L-Lactate Dehydrogenase