title: Spectrum of physiological and pathological cardiac and pericardial uptake of FDG in oncology PET-CT.
abstract: Cardiac uptake of 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) is frequently observed on FDG positron-emission tomography combined with computed tomography (PET-CT) performed for diagnosis, staging, and assessment of therapeutic response of lymphoma and solid cancers, despite careful patient preparation to limit myocardial glucose substrate utilisation. We illustrate the varied physiological patterns of cardiac FDG uptake, and show a spectrum of pathological conditions causing FDG uptake within myocardial and pericardial structures, due to clinically important benign and malignant diseases. Recognition and awareness of these various causes of FDG uptake in the heart, along with the appropriate use of correlative contrast-enhanced CT and magnetic resonance imaging (MRI) will facilitate correct interpretation.
authors.affiliation: Department of Radiology, University of Michigan, Ann Arbor, MI 48109-0028, USA.
authors.forename: P
authors.initials: P
authors.lastname: Lobert
authors.forename: R K J
authors.initials: RK
authors.lastname: Brown
authors.forename: R A
authors.initials: RA
authors.lastname: Dvorak
authors.forename: J R
authors.initials: JR
authors.lastname: Corbett
authors.forename: E A
authors.initials: EA
authors.lastname: Kazerooni
authors.forename: K K
authors.initials: KK
authors.lastname: Wong
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism; D016477:Artifacts; D009202:Cardiomyopathies / Q000378:metabolism; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006325:Heart Atria / Q000378:metabolism; D006331:Heart Diseases / Q000378:metabolism*; D006352:Heart Ventricles / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism; D064847:Multimodal Imaging; D009206:Myocardium / Q000378:metabolism*; D009928:Organ Specificity; D010210:Papillary Muscles / Q000378:metabolism; D010493:Pericarditis / Q000378:metabolism; D010496:Pericardium / Q000378:metabolism*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012507:Sarcoidosis / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18