title: Perioperative changes in cardiac troponin I concentrations in dogs.
abstract: This study determines the influence of general anesthesia on serum cardiac troponin I (cTnI) concentrations in dogs. All dogs showed no abnormalities on clinical and echocardiographic examination. Venous blood samples were drawn within 12 h of induction and 12 h after discontinuation of anesthesia. Each dog was premedicated with methadone i.v. and induced with diazepam i.v. and propofol i.v.. Anesthesia was maintained using isoflurane in oxygen in combination with a continuous rate infusion of fentanyl. The cTnI concentrations were measured using a third generation chemiluminescent microparticle immunoassay with a detection limit of 0.01 ng/mL (below this level '<0.01 ng/mL'). Ten dogs (55%) had a post-anesthetic increase of cTnI concentration relative to their pre-anesthetic cTnI concentration, whereas a decrease was observed in two dogs (11%). This study shows that cTnI can increase in healthy dogs undergoing general anesthesia.
authors.affiliation: Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium. verbiest_tom@hotmail.com
authors.forename: Tom
authors.initials: T
authors.lastname: Verbiest
authors.forename: Dominique
authors.initials: D
authors.lastname: Binst
authors.forename: Tim
authors.initials: T
authors.lastname: Waelbers
authors.forename: Eva
authors.initials: E
authors.lastname: Coppieters
authors.forename: Ingeborgh
authors.initials: I
authors.lastname: Polis
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects / Q000662:veterinary; D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D004285:Dogs / Q000097:blood / Q000601:surgery; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D007262:Infusions, Intravenous / Q000662:veterinary; D007530:Isoflurane / Q000494:pharmacology; D008297:Male; D008691:Methadone / Q000494:pharmacology; D059035:Perioperative Period / Q000662:veterinary*; D015742:Propofol / Q000494:pharmacology; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I; D007530:Isoflurane; D003975:Diazepam; D008691:Methadone; D005283:Fentanyl; D015742:Propofol