title: [Neuroprotective effects of a dipeptide mimetic on the GK-2 nerve growth factor in model of permanent common carotid artery occlusion in rats].
abstract: The behavioral and biochemical effects of a new dipeptide mimetic of the GK-2 nerve growth factor (NGF) have been studied on a model of chronic cerebral ischemia induced by permanent common carotid artery occlusion in rats. It is established that subchronic intraperitoneal injections of GK-2 (0.5 mg/kg) 4 h after surgery, followed by seven more injections made every 24 h, fully prevent the death of operated animals and reduces the development of habitation deficit (open-field test) and decrease in exploratory activity (novel object examination) two weeks after surgery, as well as fully restores the viability of cerebral cortex cells and decreases the hyperexpression of HSP70 in cerebral cortex.
authors.forename: P Iu
authors.initials: PIu
authors.lastname: Povarina
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: O N
authors.initials: ON
authors.lastname: Vorontsova
authors.forename: S V
authors.initials: SV
authors.lastname: Nikolaev
authors.forename: T A
authors.initials: TA
authors.lastname: Antipova
authors.forename: R U
authors.initials: RU
authors.lastname: Ostrovskaia
authors.forename: S B
authors.initials: SB
authors.lastname: Seredin
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D040761:Biomimetic Materials / Q000494:pharmacology*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002470:Cell Survival / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002908:Chronic Disease; D004151:Dipeptides / Q000494:pharmacology*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000187:drug effects; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis; D008297:Male; D020932:Nerve Growth Factor / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats
chemical_list: D004151:Dipeptides; D018840:HSP70 Heat-Shock Proteins; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; C572946:bis(N-succinyl-glutamyllysin)hexamethylenediamine; D020932:Nerve Growth Factor