title: [Association of miR-199a expression with clinicopathologic characteristics and prognosis of renal cell carcinoma].
abstract: OBJECTIVE
  To investigate the association of miR-199a expression with the clinicopathologic characteristics and the survival of patients with renal cell carcinoma (RCC).
  
  
  METHODS
  Real-time quantitative RT-PCR was used to detect the expression of miR-199a in the tumor tissues and paired adjacent normal tissues from 67 patients with RCC. The correlations of miR-199a expression with the clinicopathologic characteristics and survival of RCC patients were analyzed.
  
  
  RESULTS
  Positive miR-199a expression was detected in both the RCC and adjacent normal tissues, but the tumor tissues showed a significantly lower expression level by a mean of 13.7 folds (P=0.003). The expression of miR-199a was negatively correlated with tumor recurrence in RCC patients in T stage (P<0.05), but showed no significant correlations with the patients age, histological type of the tumor, lymph node metastasis, distal metastasis, or Fuhrman grade (P>0.05). The patients with lowered miR-199a expression in the tumor tissue had a significantly shorter mean survival time than those without miR-199a down-regulation (P=0.017 by Log-rank test).
  
  
  CONCLUSIONS
  A decreased expression of miR-199a is significantly correlated with a higher tumor stage, a greater likeliness of tumor recurrence, and a poorer prognosis in RCC patients. miR-199a can serve as a promising prognostic factor of renal cell carcinoma.
authors.affiliation: Department of Urinary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China. st1.0@163.com
authors.forename: Tong
authors.initials: T
authors.lastname: Si
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Liu
authors.forename: Kai
authors.initials: K
authors.lastname: Xu
authors.forename: Yaoting
authors.initials: Y
authors.lastname: Gui
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology*; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis
chemical_list: D035683:MicroRNAs; C531408:mirn199 microRNA, human