title: Toxicities, complications, and clinical encounters during intraperitoneal chemotherapy in 17 women with ovarian cancer.
abstract: OBJECTIVE
  Intraperitoneal (IP) chemotherapy is a viable and superior treatment to standard intravenous (IV) chemotherapy in women with small volume residual ovarian cancer following optimal debulking. Despite this clinical advantage, widespread adoption of the treatment regimen has been hampered by concerns related to toxicities and complications. The purpose of this descriptive study was to describe nursing implications related to toxicities, complications and clinical encounters in 17 women with ovarian cancer who received IP chemotherapy.
  
  
  METHODS
  Women with ovarian cancer who received IP chemotherapy at one NCI-designated comprehensive cancer center were accrued. Data related to IP chemotherapy summary, clinical encounters and admissions were obtained through comprehensive chart audits.
  
  
  RESULTS
  Common treatment-related toxicities included nausea and vomiting, fatigue, hypomagnesia, pain, neuropathy, anemia, and constipation. Reasons for dose-modifications were multi-factorial, and were primarily related to catheter complications and chemotherapy toxicities. The number of clinical encounters was high, and they were primarily related to admissions for inpatient IP chemotherapy and follow-up clinic visits.
  
  
  CONCLUSIONS
  Treatment-related toxicities and complications were common in women with ovarian cancer who received IP chemotherapy. Use of IP chemotherapy results in multiple clinical encounters, such as outpatient clinic visits and inpatient admissions. Nursing is a critical part of the interdisciplinary approach in caring for women treated with IP chemotherapy. Interdisciplinary teams with high levels of knowledge and skills related to IP chemotherapy administration are needed to manage treatment-related toxicities and complications, and support multiple clinical encounters during treatment.
authors.affiliation: City of Hope - Nursing Research and Education, 1500 East Duarte Road, Duarte, CA 91010, USA. vsun@coh.org
authors.forename: Virginia
authors.initials: V
authors.lastname: Sun
authors.forename: Shirley
authors.initials: S
authors.lastname: Otis-Green
authors.forename: Robert
authors.initials: R
authors.lastname: Morgan
authors.forename: Mark
authors.initials: M
authors.lastname: Wakabayashi
authors.forename: Amy
authors.initials: A
authors.lastname: Hakim
authors.forename: Maria Elenita
authors.initials: ME
authors.lastname: Callado
authors.forename: Eunice
authors.initials: E
authors.lastname: Yang
authors.forename: Betty
authors.initials: B
authors.lastname: Ferrell
authors.forename: Marcia
authors.initials: M
authors.lastname: Grant
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D002173:Cancer Care Facilities; D002404:Catheterization / Q000009:adverse effects / Q000379:methods; D017024:Chemotherapy, Adjuvant; D016208:Databases, Factual; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007274:Injections, Intraperitoneal; D008875:Middle Aged; D018365:Neoplasm, Residual; D024802:Nurse's Role; D009859:Oncology Nursing / Q000379:methods; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000451:nursing* / Q000601:surgery; D010052:Ovariectomy / Q000379:methods; D012494:Sampling Studies; D016896:Treatment Outcome