title: α-Tocopherol and lipid profiles in plasma and the expression of α-tocopherol-related molecules in the liver of Opisthorchis viverrini-infected hamsters.
abstract: Opisthorchis viverrini infection induces inflammation-mediated oxidative stress and liver injury, which may alter α-tocopherol and lipid metabolism. We investigated plasma α-tocopherol and lipid profiles in hamsters infected with O. viverrini. Levels of α-tocopherol, cholesterol, and low-density lipoprotein increased in the acute phase of infection. In the chronic phase, α-tocopherol decreased, while triglyceride and very low-density lipoprotein increased. Notably, high-density lipoprotein decreased both in the acute and chronic phases. In the liver, cholesteryl oleate, triolein, and oleic acid decreased in the acute phase, and increased in the chronic phase. Such chronological changes were negatively correlated with the plasma α-tocopherol level. The expression of α-tocopherol-related molecules, ATP-binding cassette transporter A1 (ABCA1) and α-tocopherol transfer protein, increased throughout the experiment. These results suggest that O. viverrini infection profoundly affects on lipid and α-tocopherol metabolism in due course of infection.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Umawadee
authors.initials: U
authors.lastname: Laothong
authors.forename: Porntip
authors.initials: P
authors.lastname: Pinlaor
authors.forename: Patcharee
authors.initials: P
authors.lastname: Boonsiri
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hiraku
authors.forename: Jarinya
authors.initials: J
authors.lastname: Khoontawad
authors.forename: Nuttanan
authors.initials: N
authors.lastname: Hongsrichan
authors.forename: Lakhanawan
authors.initials: L
authors.lastname: Charoensuk
authors.forename: Somchai
authors.initials: S
authors.lastname: Pinlaor
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D006224:Cricetinae; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D009889:Opisthorchiasis / Q000469:parasitology*; D009891:Opisthorchis / Q000502:physiology*; D018384:Oxidative Stress; D024502:alpha-Tocopherol / Q000097:blood*
chemical_list: D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; D008055:Lipids; D008074:Lipoproteins; C017763:alpha-tocopherol transfer protein; D024502:alpha-Tocopherol