title: Association between non-atopic hand eczema and interleukin-13 gene polymorphism in Taiwanese nursing population.
abstract: Chronic hand eczema is an important occupational skin disease with atopic dermatitis (AD) and wet work being the most important risk factors. This study was launched to analyse the potential association between AD-related inflammation genes and development of non-atopic hand eczema among nurses in University Hospital. Atopic eczema, non-atopic hand dermatitis and control groups were identified. The association between occurrence of non-atopic hand eczema and interleukin (IL)-13, IL-4 and IL-5 gene variants was analysed. IL13 rs20541 A allele [assuming recessive model; odds ratio (OR) = 3.38, 95% CI: (1.63-7.00)] showed association with development of non-atopic hand eczema. Additive score analyses showed combination of this gene variant with previously identified risk factors including certain SPINK5 polymorphism and more than 10 years of work experience conferred highest risk for development of non-atopic hand eczema. As non-atopic hand eczema made up significant portion of occupational skin diseases, further studies should be focused on this commonly encountered skin condition.
authors.forename: Yin-Chun
authors.initials: YC
authors.lastname: Chen
authors.forename: Hung-Pin
authors.initials: HP
authors.lastname: Tu
authors.forename: Ching-Shuang
authors.initials: CS
authors.lastname: Wu
authors.forename: Ying-Chin
authors.initials: YC
authors.lastname: Ko
authors.forename: Hsin-Su
authors.initials: HS
authors.lastname: Yu
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Lu
authors.forename: Wan-Chen
authors.initials: WC
authors.lastname: Li
authors.forename: Gwo-Shing
authors.initials: GS
authors.lastname: Chen
authors.forename: Cheng-Che E
authors.initials: CC
authors.lastname: Lan
mesh_terms: D000328:Adult; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006229:Hand Dermatoses / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D009740:Nursing Staff / Q000706:statistics & numerical data*; D009784:Occupational Diseases / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
chemical_list: C578095:IL13 protein, human; D018793:Interleukin-13