title: A novel distribution of visual field test points to improve the correlation between structure-function measurements.
abstract: OBJECTIVE
  To create a new visual field (VF) test grid centered at the optic disc (disc-centered field [DCF]) and to infer the combination of VF test points (structure-function field [SFF]), taken from the DCF and the conventional fovea-centered 24-2 grid (24-2) of standard automated perimetry, which yields the strongest sectorial correlation between structure-function measurements of retinal nerve fiber layer (RNFL) thickness and VF sensitivity.
  
  
  METHODS
  In 50 eyes with ocular hypertension or open angle glaucoma, the DCF and 24-2 VF were measured with a humphrey field analyzer II (Full Threshold strategy) and RNFL thickness was measured with Stratus optical coherence tomography. test points from the DCF and 24-2 VF Were combined and divided into 12 sectors according to the spatial distribution of the RNFL. A novel VF for structure-function studies was established using the following criteria: each sector must contain at least one or two test points (depending on the sector's location), and the combination of test points which yields the strongest structure-function correlation is selected.
  
  
  RESULTS
  The SFF consisted of 40 test points. The structure-function correlation for the SFF was compared with the standard 24-2 VF; a multiple-comparison test for dependent groups was carried out using a percentile bootstrap method, which indicated that the sector correlation coefficients in the SFF were significantly higher than those in the 24-2 VF.
  
  
  CONCLUSIONS
  The SFF, with fewer test locations, has a stronger structure-function correlation than the 24-2 VF. This improved correlation may help clinicians to better interpret functional measurements in relation to structural measurements.
authors.affiliation: NIHR Biomedical Research Centre, Moorfields Eye Hospital National Health Service Foundation Trust and University College London, Institute of Ophthalmology, London, United Kingdom. rasaoka-tky@umin.ac.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Asaoka
authors.forename: Richard A
authors.initials: RA
authors.lastname: Russell
authors.forename: Rizwan
authors.initials: R
authors.lastname: Malik
authors.forename: David P
authors.initials: DP
authors.lastname: Crabb
authors.forename: David F
authors.initials: DF
authors.lastname: Garway-Heath
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*