title: [Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia].
abstract: The importance of accurate and early diagnosis of dementia with Lewy bodies (DLB) lies in its pharmacological management. Delayed imaging of cardiac (123)I-MIBG scintigraphy allows differentiation between DLB and other neurodegenerative diseases with cognitive impairment. The aim of this study was to assess the utility of early imaging of cardiac (123)I-MIBG scintigraphy for differentiating DLB from others neurodegenerative disease with cognitive impairment.
  
  
  METHODS
  We assess retrospectively 106 patients (51 men, mean age 78 years) with cognitive impairment that underwent a cardiac (123)I-MIBG study. Planar images were acquired in anterior view of the thorax 15min (early) and 4h (delayed) after tracer administration. The heart-to-mediastinum ratios (HMR) at 15m (HMR15m) and at 4h (HMR4h) were obtained.
  
  
  RESULTS
  After four years, 52 patients were diagnosed of DLB.HMR15m and HMR4h were significantly inferior in DLB respect to the others neurodegenerative diseases (1,27±0,15 vs 1,76±0,15,p<0,05) and (1,14±0,13 vs 1,68±0,19,p<0.01), respectively. The ROC analysis showed a HMR15m cut off point of 1.56 to differentiated DLB from the other dementias with a sensitivity and a specificity of 98%.
  
  
  CONCLUSIONS
  Early imaging of cardiac (123)I-MIBG scintigraphy can help to differentiate DLB from other neurodegenerative diseases with cognitive impairment.
authors.affiliation: Servicio de Medicina Nuclear, Hospital de Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España. mcamachom@santpau.cat
authors.forename: V
authors.initials: V
authors.lastname: Camacho
authors.forename: M
authors.initials: M
authors.lastname: Estorch
authors.forename: M
authors.initials: M
authors.lastname: Marquié
authors.forename: A
authors.initials: A
authors.lastname: Domènech
authors.forename: A
authors.initials: A
authors.lastname: Flotats
authors.forename: A
authors.initials: A
authors.lastname: Fernández
authors.forename: J
authors.initials: J
authors.lastname: Duch
authors.forename: L L
authors.initials: LL
authors.lastname: Geraldo
authors.forename: J
authors.initials: J
authors.lastname: Deportos
authors.forename: C
authors.initials: C
authors.lastname: Artigas
authors.forename: A
authors.initials: A
authors.lastname: Lleó
authors.forename: I
authors.initials: I
authors.lastname: Carrió
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D057791:Cardiac Imaging Techniques / Q000379:methods; D003072:Cognition Disorders / Q000150:complications / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation*; D006801:Humans; D007457:Iodine Radioisotopes; D020961:Lewy Body Disease / Q000000981:diagnostic imaging*; D008297:Male; D019636:Neurodegenerative Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine