title: Current trends in epigenetic drug discovery.
abstract: Epigenetics is a major field of biomedical research, and epigenetic drug discovery shows great promise for new drugs. The first epigenetic inhibitors are already approved for human treatment. Here, we review a number of case studies that cover different aspects of epigenetic drug discovery spanning from sequencing of epigenetic modifications, assays development over screening to medicinal chemistry, in vivo testing and clinical application.
authors.affiliation: Institute of Pharmaceutical Sciences, University of Freiburg, Albertstrasse 25, 79104 Freiburg, Germany.
authors.forename: Diana A
authors.initials: DA
authors.lastname: Stolfa
authors.forename: Oliver
authors.initials: O
authors.lastname: Einsle
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sippl
authors.forename: Manfred
authors.initials: M
authors.lastname: Jung
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods; D055808:Drug Discovery / Q000379:methods*; D044127:Epigenesis, Genetic / Q000187:drug effects*; D057890:Epigenomics / Q000379:methods; D057166:High-Throughput Screening Assays / Q000379:methods; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010600:Pharmacology
chemical_list: D004364:Pharmaceutical Preparations