title: Microvenular hemangioma-an immunohistochemical study of 9 cases.
abstract: Microvenular hemangioma (MH) is a rare benign acquired vascular neoplasm, which can be clinically and histologically misdiagnosed with other vascular lesions. Immunohistochemistry studies in MH are lacking. The aim of this study is to investigate the immunoprofile of MH and gain further insight in its histogenesis. We evaluated 9 cases of MH. Immunohistochemical expression of WT1, GLUT-1, and D2-40 was performed in all cases. All 9 MHs resulted completely positive for WT1 immunostaining. Immunohistochemistry performed in all 9 MH cases showed negative staining for GLUT-1 and D2-40. We added further support to the importance of WT1 as a useful tool in the diagnosis of vascular neoplasms. D2-40 negativity in all tested lesions implied that MH does not exhibit a lymphatic differentiation. GLUT-1, which is characteristically positive in infantile hemangioma and verrucous hemangioma, showed to be negative in MHs.
authors.affiliation: Department of Dermatology, Hospital de Cascais Dr. José de Almeida, Lisbon, Portugal.
authors.forename: Felicidade
authors.initials: F
authors.lastname: Trindade
authors.forename: Heinz
authors.initials: H
authors.lastname: Kutzner
authors.forename: Luis
authors.initials: L
authors.lastname: Requena
authors.forename: Óscar
authors.initials: Ó
authors.lastname: Tellechea
authors.forename: Isabel
authors.initials: I
authors.lastname: Colmenero
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D006391:Hemangioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor