title: MDR1 in paroxetine-induced sexual dysfunction.
abstract: Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001).
authors.affiliation: Central European Institute of Technology, Masaryk University, Brno, Czech Republic. azourkova@fnbrno.cz
authors.forename: Alexandra
authors.initials: A
authors.lastname: Zourková
authors.forename: Ondřej
authors.initials: O
authors.lastname: Slanař
authors.forename: Jiří
authors.initials: J
authors.lastname: Jarkovský
authors.forename: Ivana
authors.initials: I
authors.lastname: Palčíková
authors.forename: Eva
authors.initials: E
authors.lastname: Pindurová
authors.forename: Michaela
authors.initials: M
authors.lastname: Cvanová
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage*; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000235:genetics; D052018:Bulimia Nervosa / Q000188:drug therapy* / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced* / Q000235:genetics; D055815:Young Adult
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018687:Antidepressive Agents, Second-Generation