title: A cyclometallated platinum complex as a selective optical switch for quadruplex DNA.
abstract: Hits the spot: A cyclometalled platinum(II) complex with a substituted phenanthroline ligand is reported. The complex has high in vitro affinity for quadruplex DNA and upon binding its emission is switched on. The complex can be easily delivered to the cell by using a metallo-cage as a carrier (see illustration). By means of confocal microscopy, it is shown that the complex is released inside the cell, penetrates the nucleus and localises in the nucleoli.
authors.affiliation: Department of Chemistry, Imperial College London, London SW7 2AZ, UK.
authors.forename: Kogularamanan
authors.initials: K
authors.lastname: Suntharalingam
authors.forename: Anna
authors.initials: A
authors.lastname: Łęczkowska
authors.forename: Mona A
authors.initials: MA
authors.lastname: Furrer
authors.forename: Yilei
authors.initials: Y
authors.lastname: Wu
authors.forename: Marina K
authors.initials: MK
authors.lastname: Kuimova
authors.forename: Bruno
authors.initials: B
authors.lastname: Therrien
authors.forename: Andrew J P
authors.initials: AJ
authors.lastname: White
authors.forename: Ramon
authors.initials: R
authors.lastname: Vilar
mesh_terms: D054856:G-Quadruplexes; D008024:Ligands; D008958:Models, Molecular; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*
chemical_list: D008024:Ligands; D009944:Organoplatinum Compounds; D010618:Phenanthrolines