title: Atypical chronic lymphocytic inflammation with pontocerebellar perivascular enhancement responsive to steroids (CLIPPERS), primary angiitis of the CNS mimicking CLIPPERS or overlap syndrome? A case report.
abstract: A novel type of encephalomyelitis was first described as chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in 2010 and few additional patients were reported since then. Partially due to its unknown aetiology and a lack of pathognomonic features some have suggested that CLIPPERS may not represent a distinct disease, but rather a syndrome with different underlying aetiologies. Here we report a 49-year-old German female who presented with a number of clinical and paraclinical features described as typical for CLIPPERS, while additionally showing symptoms and findings compatible with primary angiitis of the CNS (PACNS). This case may establish a previously unnoted link between two poorly understood autoimmune conditions of the CNS.
authors.affiliation: Department of Neurology, University of Würzburg, Würzburg, Germany. m.buttmann@uni-wuerzburg.de
authors.forename: Mathias
authors.initials: M
authors.lastname: Buttmann
authors.forename: Imke
authors.initials: I
authors.lastname: Metz
authors.forename: Isabel
authors.initials: I
authors.lastname: Brecht
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Brück
authors.forename: Monika
authors.initials: M
authors.lastname: Warmuth-Metz
mesh_terms: D001921:Brain / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D003937:Diagnosis, Differential; D004172:Diplopia / Q000209:etiology; D004660:Encephalitis / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D020233:Gait Disorders, Neurologic / Q000209:etiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008214:Lymphocytes / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011149:Pons / Q000473:pathology; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*