title: In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography.
abstract: The most common technology for seizure detection is with electroencephalography (EEG), which has low spatial resolution and minimal depth discrimination. Optical techniques using near-infrared (NIR) light have been used to improve upon EEG technology and previous research has suggested that optical changes, specifically changes in near-infrared optical scattering, may precede EEG seizure onset in in vivo models. Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth resolved cross-sectional images. In this study, OCT was used to detect changes in optical properties of cortical tissue in vivo in mice before and during the induction of generalized seizure activity. We demonstrated that a significant decrease (P < 0.001) in backscattered intensity during seizure progression can be detected before the onset of observable manifestations of generalized (stage-5) seizures. These results indicate the feasibility of minimally-invasive optical detection of seizures with OCT.
authors.affiliation: Department of Bioengineering, University of California, Riverside, 900 University Ave., Riverside, CA 92521,  USA.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Eberle
authors.forename: Carissa L
authors.initials: CL
authors.lastname: Reynolds
authors.forename: Jenny I
authors.initials: JI
authors.lastname: Szu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Anne M
authors.initials: AM
authors.lastname: Hansen
authors.forename: Mike S
authors.initials: MS
authors.lastname: Hsu
authors.forename: M Shahidul
authors.initials: MS
authors.lastname: Islam
authors.forename: Devin K
authors.initials: DK
authors.lastname: Binder
authors.forename: B Hyle
authors.initials: BH
authors.lastname: Park