title: Metal-mediated targeting in the body.
abstract: Metal ions are important for many biological processes and are steadily available in the human body. Metal concentrations can be extremely high in diseased areas of various pathological conditions. Some synthetic and natural drugs need to be activated by metal ions as prodrugs. In this review, we provide a few examples to illustrate how metal ions activate and mediate drug targeting in the body. This knowledge may be helpful for the development of more effective drugs and pharmaceutical formulations.
authors.affiliation: College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Tang
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Liang
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000378:metabolism; D001596:Benzylamines; D001761:Bleomycin / Q000737:chemistry / Q000378:metabolism; D000080027:Cyclams; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D000080890:Duocarmycins; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000378:metabolism; D007477:Ions / Q000737:chemistry; D008670:Metals / Q000737:chemistry* / Q000378:metabolism; D063065:Organophosphonates / Q000737:chemistry / Q000378:metabolism; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001596:Benzylamines; D000080027:Cyclams; D000080890:Duocarmycins; D006571:Heterocyclic Compounds; D007211:Indoles; D007477:Ions; D008670:Metals; D063065:Organophosphonates; D011355:Prodrugs; D011760:Pyrrolidinones; D001761:Bleomycin; D004247:DNA; C058289:duocarmycin A; C088327:plerixafor