title: Asymmetric hydrogenation of α,α'-disubstituted cycloketones through dynamic kinetic resolution: an efficient construction of chiral diols with three contiguous stereocenters.
abstract: Chiral diols with three contiguous stereocenters were synthesized by a highly enantioselective ruthenium-catalyzed asymmetric hydrogenation of racemic α,α'-disubstituted cycloketones involving dynamic kinetic resolution. This new catalytic asymmetric method provides a concise route to the alkaloid (+)-γ-lycorane.
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Liu
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Xie
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Li
authors.forename: Ji-Qiang
authors.initials: JQ
authors.lastname: Chen
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou