title: Therapeutic potential of growth factors in pulmonary emphysematous condition.
abstract: Pulmonary emphysema is a major manifestation of chronic obstructive pulmonary disease (COPD), which is characterized by progressive destruction of alveolar parenchyma with persistent inflammation of the small airways. Such destruction in the distal respiratory tract is irreversible and irreparable. All-trans-retinoic acid was suggested as a novel therapy for regeneration of lost alveoli in emphysema. However, profound discrepancies were evident between studies. At present, no effective therapeutic options are available that allow for the regeneration of lost alveoli in emphysematous human lungs. Recently, some reports on rodent's models have suggested the beneficial effects of various growth factors toward alveolar maintenance and repair processes.
authors.affiliation: Department of Biotechnology, School of Biotechnology, Gautam Buddha University, Greater Noida, 201308, India. jmuyal@gbu.ac.in
authors.forename: Jai Prakash
authors.initials: JP
authors.lastname: Muyal
authors.forename: Vandana
authors.initials: V
authors.lastname: Muyal
authors.forename: Sudhir
authors.initials: S
authors.lastname: Kotnala
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Kumar
authors.forename: Harsh
authors.initials: H
authors.lastname: Bhardwaj
mesh_terms: D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000009:adverse effects / Q000096:biosynthesis / Q000235:genetics / Q000627:therapeutic use*; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D011656:Pulmonary Emphysema / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D033581:Stem Cell Transplantation / Q000379:methods*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D011994:Recombinant Proteins