title: Transcription: base J blocks the way.
abstract: How do cells stop transcribing RNA Polymerase II to promote proper gene expression and prevent transcriptional havoc in the genome? In the case of Leishmania, a uniquely modified DNA base blocks RNA Polymerase II and suggests an interesting new model for transcription termination.
authors.affiliation: Department of Biological Chemistry, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA.
authors.forename: Dane Z
authors.initials: DZ
authors.lastname: Hazelbaker
authors.forename: Stephen
authors.initials: S
authors.lastname: Buratowski
mesh_terms: D000818:Animals; D018503:Genome, Protozoan; D005960:Glucosides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D007891:Leishmania / Q000378:metabolism; D015394:Molecular Structure; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
chemical_list: D005960:Glucosides; C084880:5-((glucopyranosyloxy)methyl)uracil; D014498:Uracil; D012319:RNA Polymerase II