title: Comparison of splicing factor 3b inhibitors in human cells.
abstract: Name your splice: FR901464 analogues and herboxidiene inhibit constitutive splicing, most likely by inhibiting spliceosomal subunit SF3b. A parallel comparison of these compounds in a cell-based assay system showed meayamycin B as the most potent splicing inhibitor among these small molecules.
authors.affiliation: Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Andreas
authors.initials: A
authors.lastname: Vogt
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Forsyth
authors.forename: Kazunori
authors.initials: K
authors.lastname: Koide
mesh_terms: D000818:Animals; D005091:Exons / Q000235:genetics; D017930:Genes, Reporter / Q000235:genetics; D057809:HEK293 Cells; D006801:Humans; D007438:Introns / Q000235:genetics; D049409:Luciferases, Firefly / Q000235:genetics; D009025:Morpholines / Q000494:pharmacology*; D011714:Pyrans / Q000494:pharmacology*; D012326:RNA Splicing / Q000187:drug effects*; D017413:Ribonucleoprotein, U2 Small Nuclear / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014305:Triose-Phosphate Isomerase / Q000235:genetics
chemical_list: D009025:Morpholines; D011714:Pyrans; D017413:Ribonucleoprotein, U2 Small Nuclear; C585895:meayamycin B; C088049:splicing factor 3a; D049409:Luciferases, Firefly; D014305:Triose-Phosphate Isomerase