title: Vitamin D as a predictor of insulin resistance in polycystic ovarian syndrome.
abstract: BACKGROUND
  Polycystic Ovary Syndrome (PCOS) is the most common endocrinological disorder in women in the reproductive age group. The salient features of this condition include hyperandrogenic features, infertility and insulin resistance among others. Mechanisms behind these features are a matter of debate. Vitamin D has been implicated lately in the etiology of many disorders. The aim of our study was to assess the role of vitamin D as an etiological and predictive factor in PCOS.
  
  
  METHODS
  The study comprised 60 proven cases of PCOS diagnosed on the basis of Rotterdam criteria. The parameters assessed include HOMA-IR, vitamin D besides the routine anthropometric and biochemical parameters.
  
  
  RESULTS
  The study population was divided into 3 groups according to vitamin D status. Insulin resistance was most severe in the sub group with vitamin D deficiency. Multiple regression analysis established the role of vitamin D as the best predictor of insulin resistance in our study.
  
  
  CONCLUSIONS
  Vitamin D has an important role in the pathogenesis of insulin resistance in PCOS.
authors.affiliation: Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India. drsurajeetlhmc@gmail.com
authors.forename: Surajeet K
authors.initials: SK
authors.lastname: Patra
authors.forename: Huma
authors.initials: H
authors.lastname: Nasrat
authors.forename: Binita
authors.initials: B
authors.lastname: Goswami
authors.forename: Anju
authors.initials: A
authors.lastname: Jain
mesh_terms: D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood* / Q000453:epidemiology; D007194:India / Q000453:epidemiology; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000453:epidemiology; D011237:Predictive Value of Tests; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D014815:Vitamins / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D014815:Vitamins; D014807:Vitamin D