title: Presurgical lateralization of seizure focus in temporal lobe epilepsy with noninvasive imaging.
abstract: We retrospectively compared the seizure focus-localizing capability of interictal PET/CT to that of interictal magnetic resonance diffusion-weighted imaging and ictal SPECT in 21 patient candidate for neurosurgery with temporal lobe epilepsy (TLE) by assessing overall lateralizing ability of these modalities and concordance of findings on these studies with results of electroencephalography (EEG). PET/CT demonstrated the greatest lateralizing ability of any of the imaging modalities and had the highest concordance rate for lateralization with EEG, highlighting its increasing diagnostic utility in the preoperative imaging workup of patients with medically intractable TLE.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Johns Hopkins University School of Medicine and The Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: Jay J
authors.initials: JJ
authors.lastname: Pillai
authors.forename: Hadyn T
authors.initials: HT
authors.lastname: Williams
authors.forename: Scott E
authors.initials: SE
authors.lastname: Forseen
authors.forename: Yong D
authors.initials: YD
authors.lastname: Park
mesh_terms: D003952:Diagnostic Imaging; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D057234:Preoperative Period; D012640:Seizures / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D055815:Young Adult