title: Development of mucoadhesive drug delivery system using phenylboronic acid functionalized poly(D,L-lactide)-b-dextran nanoparticles.
abstract: Mucoadhesive NP drug carriers have attracted substantial interest as a potential treatment for anterior eye diseases. NPs composed of PLA-Dex surface functionalized with a mucoadhesive ligand, PBA, were developed as drug carriers with particle sizes ranging from 25 to 28 nm. Using CycA as a model drug, we showed that NPs encapsulated up to 13.7 wt% CycA and exhibited sustained release for up to 5 d in vitro at a clinically relevant dose. We fine-tuned the PBA density on the NP surface to maximize the mucin-NP interaction without compromising the particle stability in vitro. This block copolymer conjugate may be useful to improve the bioavailability of topical formulations.
authors.affiliation: Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.
authors.forename: Shengyan
authors.initials: S
authors.lastname: Liu
authors.forename: Lyndon
authors.initials: L
authors.lastname: Jones
authors.forename: Frank X
authors.initials: FX
authors.lastname: Gu
mesh_terms: D000268:Adhesiveness; D001897:Boronic Acids / Q000737:chemistry*; D003316:Corneal Diseases / Q000188:drug therapy*; D003692:Delayed-Action Preparations / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009077:Mucins / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D003692:Delayed-Action Preparations; D003911:Dextrans; D009077:Mucins; D011091:Polyesters; C033616:poly(lactide); C010686:benzeneboronic acid