title: Diabetic cardiomyopathy: pathophysiological mechanisms and cardiac dysfuntion.
abstract: Several experimental, pathological, epidemiological, and clinical studies have clearly depicted that diabetes mellitus results in cardiac functional and structural changes. Diabetic cardiomyopathy results in both structural and functional alterations in the myocardium. Several mechanisms have been implicated in the pathophysiology of diabetic cardiomyopathy. Of these, metabolic disturbances, myocardial fibrosis, small vessel disease, and cardiac autonomic neuropathy are the major players in the pathophysiology of diabetic cardiomyopathy. This review is intended to discuss various such pathophysiological mechanisms of diabetic cardiomyopathy. We have also described the systolic and diastolic dysfunctioning and its corelation to structural changes in diabetes.
authors.affiliation: Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.
authors.forename: B R
authors.initials: BR
authors.lastname: Goyal
authors.forename: A A
authors.initials: AA
authors.lastname: Mehta
mesh_terms: D058065:Diabetic Cardiomyopathies / Q000378:metabolism / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D009206:Myocardium / Q000473:pathology
chemical_list: D005230:Fatty Acids, Nonesterified