title: Influence of SYSADOA group chemicals on progression of human knee joint osteoarthritis: new objective evaluation method - measuring of rheological properties in vivo.
abstract: OBJECTIVE
  This study seeks to demonstrate the influence of pharmacological substances from the SYSADOA group on the progression of osteoarthritis in the human knee. The quantification methods were direct measurement of the rheological properties of the knee joints in vivo and standard WOMAC index questionnaires.
  
  
  METHODS
  The drugs were administered orally to 34 probands with second degree gonarthrosis for 13 weeks. The untreated control group consisted of 10 probands. The rheological properties of the joints were determined by a biorheometer, and subjective assessment of the knees by patients (WOMAC) before and after medication, and for a further 13 weeks. Changes in the calculated parameters over time were compared.
  
  
  RESULTS
  During the audited perioda slight deterioration in all of the parameters was observed in the untreated group. The treated group, however, improved in all the parameters and some indicators showed statistically significant differences. The positive effects of the SYSADOA persisted for 3 months after the end of treatments. Partial correlation was found between the results of the WOMAC questionnaire and the rheological measurements.
  
  
  CONCLUSIONS
  This study shows the positive effects of the preparation on arthritic changes in the knee joint, but due to the large variance of the collected data, this conclusion is on the borderline of statistical significance. The method of measuring the rheological properties of the joints is suitable for evaluating the progression of OA.
authors.affiliation: Department of Anatomy and Biomechanics, Faculty of Physical Education and Sport, Laboratory of Biomechanics of Extreme Loading, Charles University, Czech Republic. kubovy.petr@seznam.cz
authors.forename: Petr
authors.initials: P
authors.lastname: Kubový
authors.forename: Lucie
authors.initials: L
authors.lastname: Mensíková
authors.forename: Eva
authors.initials: E
authors.lastname: Kůrková
authors.forename: Frantisek
authors.initials: F
authors.lastname: Lopot
authors.forename: Vladimír
authors.initials: V
authors.lastname: Hojka
authors.forename: Karel
authors.initials: K
authors.lastname: Jelen
mesh_terms: D000368:Aged; D001696:Biomechanical Phenomena / Q000187:drug effects; D002809:Chondroitin Sulfates / Q000008:administration & dosage; D018450:Disease Progression; D005260:Female; D005944:Glucosamine / Q000008:administration & dosage; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage; D007719:Knee Joint / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D020370:Osteoarthritis, Knee / Q000175:diagnosis* / Q000188:drug therapy*; D012212:Rheology / Q000379:methods*; D016896:Treatment Outcome; D055675:Viscosupplements / Q000008:administration & dosage*
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates; D005944:Glucosamine