title: Bactericidal/permeability increasing protein: a multifaceted protein with functions beyond LPS neutralization.
abstract: Bactericidal permeability increasing protein (BPI), a 55-60 kDa protein, first reported in 1975, has gone a long way as a protein with multifunctional roles. Its classical role in neutralizing endotoxin (LPS) raised high hopes among septic shock patients. Today, BPI is not just a LPS-neutralizing protein, but a protein with diverse functions. These functions can be as varied as inhibition of endothelial cell growth and inhibition of dendritic cell maturation, or as an anti-angiogenic, chemoattractant or opsonization agent. Though the literature available is extremely limited, it is fascinating to look into how BPI is gaining major importance as a signalling molecule. In this review, we briefly summarize the recent research focused on the multiple roles of BPI and its use as a therapeutic.
authors.affiliation: Department of Microbiology and Cell Biology, Centre for Infectious Disease Research and Biosafety Laboratories, Indian Institute of Science, India.
authors.forename: Arjun
authors.initials: A
authors.lastname: Balakrishnan
authors.forename: Sandhya A
authors.initials: SA
authors.lastname: Marathe
authors.forename: Madhura
authors.initials: M
authors.lastname: Joglekar
authors.forename: Dipshikha
authors.initials: D
authors.lastname: Chakravortty
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000276:immunology / Q000378:metabolism*; D001798:Blood Proteins / Q000276:immunology / Q000378:metabolism*; D002454:Cell Differentiation; D048708:Cell Growth Processes; D002633:Chemotaxis; D016905:Gram-Negative Bacterial Infections / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007113:Immunity, Innate; D008070:Lipopolysaccharides / Q000276:immunology; D018919:Neovascularization, Physiologic; D010587:Phagocytosis; D018805:Sepsis / Q000276:immunology* / Q000628:therapy; D015398:Signal Transduction / Q000276:immunology
chemical_list: D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D008070:Lipopolysaccharides; C021623:bactericidal permeability increasing protein