title: Tumor-cell-derived microvesicles as carriers of molecular information in cancer.
abstract: OBJECTIVE
  Exosomes and microvesicles are secreted particles of 30-200  nm in diameter, delimited by a lipid bilayer and containing a wide range of membrane-bound or free proteins and nucleic acids (in particular mRNA and miRNA). Here, we review the properties of tumor-cell-derived microvesicles as carriers of molecular information in relation to cancer progression and promotion of metastasis.
  
  
  RESULTS
  Microvesicles from tumor cells operate as signaling platforms that diffuse in the extracellular space to target cells in the microenvironment, modulating the interactions of tumor cells with stromal, inflammatory, dendritic, immune or vascular cells and priming the formation of the metastatic niche.
  
  
  CONCLUSIONS
  Because of their stability, exosomes and microvesicles can be retrieved in bodily fluids as biomarkers for cancer detection and monitoring. They offer a range of molecular targets for controlling cell-cell interactions during invasion and metastasis.
authors.affiliation: International Research Center, Hospital AC Camargo, São Paulo, São Paulo, Brazil. vmartins@cipe.accamargo.org.br
authors.forename: Vilma R
authors.initials: VR
authors.lastname: Martins
authors.forename: Marcos S
authors.initials: MS
authors.lastname: Dias
authors.forename: Pierre
authors.initials: P
authors.lastname: Hainaut
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002450:Cell Communication; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D055354:Exosomes / Q000276:immunology / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor