title: The clinical use of Kampo medicines (traditional Japanese herbal treatments) for controlling cancer patients' symptoms in Japan: a national cross-sectional survey.
abstract: BACKGROUND
  Kampo medicines are traditional Japanese medicines produced from medicinal plants and herbs. Even though the efficacy of Kampo medicines for controlling cancer-related symptoms is being reported, their actual nationwide clinical use has not been comprehensively investigated. We aimed to investigate physicians' recognition of Kampo medicines and their clinical use for cancer patients in the field of palliative care.
  
  
  METHODS
  A cross-sectional self-administered anonymous questionnaire was distributed to 549 physicians working in palliative care teams at 388 core cancer treatment hospitals and 161 certified medical institutions that have palliative care units (PCUs).
  
  
  RESULTS
  Valid responses were obtained from 311 physicians (response rate, 56.7%) who were evenly distributed throughout the country without significant geographical biases. Kampo medicines were prescribed for controlling cancer-related symptoms by 64.3% of the physicians. The symptoms treated with Kampo medicines were numbness/hypoesthesia (n = 99, 49.5%), constipation (n = 76, 38.0%), anorexia/weight loss (n = 72, 36%), muscle cramps (n = 71, 35.5%) and languor/fatigue (n = 64, 32.0%). Regarding open issues about prescription, 60.7% (n = 173) of the physicians raised the issue that the dosage forms need to be better devised.
  
  
  CONCLUSIONS
  To increase the clinical use of Kampo medicines, more evidence from clinical studies is necessary. In addition, their mechanisms of action should be clarified through laboratory studies.
authors.affiliation: Department of Palliative Medicine, The University of Tokyo Hospital, 7-3-1Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Iwase
authors.forename: Takuhiro
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Tempei
authors.initials: T
authors.lastname: Miyaji
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Terawaki
authors.forename: Akio
authors.initials: A
authors.lastname: Inui
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Uezono
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D020835:Medicine, Kampo / Q000706:statistics & numerical data*; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry; D010818:Practice Patterns, Physicians'; D011795:Surveys and Questionnaires
chemical_list: D010936:Plant Extracts