title: Efficacy of endoscopic ultrasound guided fine needle aspiration in patients with solid pancreatic neoplasms.
abstract: OBJECTIVE
  Endosonography is a distinct method for evaluating the structural lesions of the gastrointestinal (GI) tract, particularly the pancreatobilliary region. This procedure has made a fundamental change in the diagnosis of pancreatic mass lesion through providing fine needle aspiration. This study aims at evaluating the results and efficacy of endoscopic ultrasound fine needle aspiration (EUS-FNA) in patients with pancreatic solid mass.
  
  
  METHODS
  The present study is an observational, prospective case series nature, evaluated patients with pancreatic solid mass referred to Imam Khomeini educational hospital in Tehran for a duration of one year since November 2010. In order to determine the false negative cases, the patients were followed-up from 6 to 12 months.
  
  
  RESULTS
  EUS-FNA was conducted on all 53 patients without any complication. The majority of patients included in the study were males (68%) and 81% of patients had a mass in the head of pancreas. The result of cytopathology revealed 36 adenocarcinomas (68%), 7 other malignancies (13%), benign lesions (6%) and 7 non-diagnostic cases (13%). The frequency of non-diagnostic results was significantly high in masses smaller than 3 cm (6 vs. 1, P < 0.002). Patients with non-diagnostic result were younger than those with malignant cytopathology (52 ± 7.5 vs. 66 ± 7.5 years, P < 0.001).. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of this procedure concerning Adenocarcinoma were 88%, 100%, 100%, 70% and 90%, respectively.
  
  
  CONCLUSIONS
  EUS - FNA is an effective and safe procedure in histopathologic diagnosis of pancreatic tumors. This procedure is useful in all pancreatic mass cases including resectable and non-resectable ones.
authors.affiliation: Department of Gastroenterology, Shahid Sadoghi University of Medical Sciences, Yazd, Iran.
authors.forename: Mahmud
authors.initials: M
authors.lastname: Baghbanian
authors.forename: Bijan
authors.initials: B
authors.lastname: Shabazkhani
authors.forename: Hadi
authors.initials: H
authors.lastname: Ghofrani
authors.forename: Hosein
authors.initials: H
authors.lastname: Forutan
authors.forename: Naser
authors.initials: N
authors.lastname: Dariani
authors.forename: Mohamadjafar
authors.initials: M
authors.lastname: Farahvash
authors.forename: Najmeh
authors.initials: N
authors.lastname: Aletaha
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000379:methods*; D005188:False Negative Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D011446:Prospective Studies; D015203:Reproducibility of Results; D055815:Young Adult