title: Emergence of Klebsiella pneumoniae-producing KPC-2 carbapenemase in Paraíba, Northeastern Brazil.
abstract: The emergence of KPC-2 producing K. pneumoniae in hospitalized patients at the intensive care unit (ICU) of a teaching hospital located in the city of João Pessoa, Paraíba, Brazil, is reported. Seven carbapenem-resistant K. pneumoniae recovered from different body sites of infection were analyzed. Most isolates showed a multidrug-resistance phenotype. Genotypic analysis demonstrated the presence of two genotypes, with the predominance of genotype A, which belongs to ST 437. These isolates also carry the encoding genes of five other beta-lactamases.
authors.affiliation: Laboratório Alerta, Division of Infectious Diseases, Universidade Federal de São Paulo, Rua Leandro Dupret 188, Vila Clementino, São Paulo, SP, Brazil. lorenafehlberg@gmail.com
authors.forename: Lorena C C
authors.initials: LC
authors.lastname: Fehlberg
authors.forename: Albalucia M C
authors.initials: AM
authors.lastname: Carvalho
authors.forename: Eloiza H
authors.initials: EH
authors.lastname: Campana
authors.forename: Paulo P
authors.initials: PP
authors.lastname: Gontijo-Filho
authors.forename: Ana C
authors.initials: AC
authors.lastname: Gales
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000187:drug effects* / Q000235:genetics; D001938:Brazil; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005838:Genotype; D006784:Hospitals, Teaching; D006801:Humans; D007362:Intensive Care Units; D007710:Klebsiella Infections / Q000201:enzymology / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D010641:Phenotype; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000187:drug effects* / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C531581:carbapenemase-2, Klebsiella pneumoniae