title: AtWRKY15 perturbation abolishes the mitochondrial stress response that steers osmotic stress tolerance in Arabidopsis.
abstract: Environmental stresses adversely affect plant growth and development. A common theme within these adverse conditions is the perturbation of reactive oxygen species (ROS) homeostasis. Here, we demonstrate that the ROS-inducible Arabidopsis thaliana WRKY15 transcription factor (AtWRKY15) modulates plant growth and salt/osmotic stress responses. By transcriptome profiling, a divergent stress response was identified in transgenic WRKY15-overexpressing plants that linked a stimulated endoplasmic reticulum-to-nucleus communication to a disrupted mitochondrial stress response under salt-stress conditions. We show that mitochondrial calcium-flux sensing might be important for regulating an active mitochondrial retrograde signaling and launching an appropriate defense response to confer salt-stress tolerance.
authors.affiliation: Department of Plant Systems Biology, VIB, 9052 Gent,  Belgium.
authors.forename: Sandy
authors.initials: S
authors.lastname: Vanderauwera
authors.forename: Korneel
authors.initials: K
authors.lastname: Vandenbroucke
authors.forename: Annelies
authors.initials: A
authors.lastname: Inzé
authors.forename: Brigitte
authors.initials: B
authors.lastname: van de Cotte
authors.forename: Per
authors.initials: P
authors.lastname: Mühlenbock
authors.forename: Riet
authors.initials: R
authors.lastname: De Rycke
authors.forename: Naïra
authors.initials: N
authors.lastname: Naouar
authors.forename: Tim
authors.initials: T
authors.lastname: Van Gaever
authors.forename: Marc C E
authors.initials: MC
authors.lastname: Van Montagu
authors.forename: Frank
authors.initials: F
authors.lastname: Van Breusegem
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D005434:Flow Cytometry; D020869:Gene Expression Profiling; D006861:Hydrogen Peroxide / Q000378:metabolism; D046228:Microarray Analysis; D008928:Mitochondria / Q000378:metabolism* / Q000502:physiology; D016297:Mutagenesis, Site-Directed; D009997:Osmotic Pressure; D060888:Real-Time Polymerase Chain Reaction; D054712:Salinity; D013312:Stress, Physiological / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D014157:Transcription Factors; C578017:WRKY15 protein, Arabidopsis; D006861:Hydrogen Peroxide; D002118:Calcium