title: Micronutrients in age-related macular degeneration.
abstract: Several lines of evidence from in vitro and in vivo studies suggest that specific micronutrients may have beneficial effects in age-related macular degeneration (AMD). Such effects appear to be complex and may include filtering short wavelength light and attenuating oxidative and inflammatory damage as well as other structural and physiological factors. There is clinical evidence for potential benefits from vitamin C, β-carotene, vitamin E and zinc, as well as emerging epidemiological and clinical data for the carotenoids lutein and zeaxanthin and for omega-3 fatty acids. A survey of the literature suggests that some specific micronutrients may be of value in treating or preventing AMD, but further prospective studies are needed to further identify and characterize their effects and place in therapy.
authors.affiliation: Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre and Institute of Human Development, University of Manchester, Manchester, UK. tariq.aslam @ manchester.ac.uk
authors.forename: Tariq
authors.initials: T
authors.lastname: Aslam
authors.forename: Cécile
authors.initials: C
authors.lastname: Delcourt
authors.forename: Rufino
authors.initials: R
authors.lastname: Silva
authors.forename: Frank G
authors.initials: FG
authors.lastname: Holz
authors.forename: Anita
authors.initials: A
authors.lastname: Leys
authors.forename: Alfredo
authors.initials: A
authors.lastname: Garcià Layana
authors.forename: Eric
authors.initials: E
authors.lastname: Souied
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D019587:Dietary Supplements; D006801:Humans; D008268:Macular Degeneration / Q000188:drug therapy*; D018977:Micronutrients / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D018977:Micronutrients; D014815:Vitamins