title: Stem cell recruitment after injury: lessons for regenerative medicine.
abstract: Tissue repair and regeneration are thought to involve resident cell proliferation as well as the selective recruitment of circulating stem and progenitor cell populations through complex signaling cascades. Many of these recruited cells originate from the bone marrow, and specific subpopulations of bone marrow cells have been isolated and used to augment adult tissue regeneration in preclinical models. Clinical studies of cell-based therapies have reported mixed results, however, and a variety of approaches to enhance the regenerative capacity of stem cell therapies are being developed based on emerging insights into the mechanisms of progenitor cell biology and recruitment following injury. This article discusses the function and mechanisms of recruitment of important bone marrow-derived stem and progenitor cell populations following injury, as well as the emerging therapeutic applications targeting these cells.
authors.affiliation: Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic & Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, 257 Campus Drive West, Hagey Building GK-201, Stanford, CA 94305-5148, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Rennert
authors.forename: Michael
authors.initials: M
authors.lastname: Sorkin
authors.forename: Ravi K
authors.initials: RK
authors.lastname: Garg
authors.forename: Geoffrey C
authors.initials: GC
authors.lastname: Gurtner
mesh_terms: D053687:Adult Stem Cells / Q000378:metabolism / Q000637:transplantation*; D000818:Animals; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D006801:Humans; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D014947:Wounds and Injuries / Q000378:metabolism / Q000628:therapy*