title: Protein-resistance performance enhanced by formation of highly-ordered perfluorinated alkyls on fluorinated polymer surfaces.
abstract: In this paper, the relationship between the surface structure of fluorinated polymers and their protein-resistant property was studied by preparing films of poly(n-alkyl methacrylate) end-capped with 2-perfluorooctylethyl methacrylate (FMA) (PFMA(y)-ec-PnAMA(x)-ec-PFMA(y)) with various ordered structures of perfluorinated alkyls. These fluorinated polymers were synthesized via a controlled/living atom-transfer radical polymerization (ATRP) method. Both the surface free energy and the CF(3)/CF(2) ratio obtained by X-ray photoelectron spectroscopy (XPS) were employed to scale the ordered structures of the perfluorinated alkyls. Protein adsorption studies using fibrinogen as a test molecule were undertaken on the various films by XPS. The results show that the adsorbed mass of fibrinogen decreased linearly with increasing CF(3)/CF(2) ratio on the fluorinated polymer surfaces. When the CF(3)/CF(2) ratio reaches 0.26, there was almost no fibrinogen adsorption. This work not only demonstrates the design of a fluorinated copolymer film on glass substrate with desirable protein-resistant performance, but also provides a fundamental understanding of how the orientation of perfluoroalkyl side chains affects protein-resistant behavior on fluorinated surfaces.
authors.affiliation: Department of Chemistry, Key Laboratory of Advanced Textile Materials and Manufacturing Technology of The Education Ministry, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Donghuan
authors.initials: D
authors.lastname: Yan
authors.forename: Huagang
authors.initials: H
authors.lastname: Ni
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Yanhang
authors.initials: Y
authors.lastname: Yang
authors.forename: Xinping
authors.initials: X
authors.lastname: Wang
mesh_terms: D005340:Fibrinogen / Q000737:chemistry*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D006845:Hydrocarbons, Fluorinated; D011108:Polymers; D005340:Fibrinogen