title: Emerging role of the ubiquitin-proteasome system as drug targets.
abstract: The ubiquitin-proteosome system (UPS) regulates a wide range of cellular processes including protein degradation, DNA repair, transcription regulation, and cell signaling. Alterations and mutations in UPS components give rise to various human diseases, most prominently cancer and neurodegenerative disorders. Here, we review recent advances in UPS-based drug discovery highlighting the emerging relationships between the UPS and disease and discuss potential future therapeutic interventions. In particular, we focus on recent structural approaches in UPS and explain how the knowledge of protein structural details can guide the design of specifically targeted inhibitors.
authors.affiliation: Center for Computational Biology and Bioinformatics and College of Engineering, Koc University, Rumelifeneri Yolu, 34450 Sariyer Istanbul, Turkey.
authors.forename: Gozde
authors.initials: G
authors.lastname: Kar
authors.forename: Ozlem
authors.initials: O
authors.lastname: Keskin
authors.forename: Franca
authors.initials: F
authors.lastname: Fraternali
authors.forename: Attila
authors.initials: A
authors.lastname: Gursoy
mesh_terms: D000818:Animals; D004260:DNA Repair / Q000502:physiology; D015195:Drug Design; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000503:physiopathology; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects*; D015398:Signal Transduction / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism*
chemical_list: D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex