title: [An experimental study of the anti-inflammatory action of noopept and its effect on the level of cytokines].
abstract: The anti-inflammatory effects of noopept (dipeptide analog of piracetam) upon a single intraperitoneal (i.p.) administration at doses of 1, 5, and 10 mg/kg in comparison to the reference drug diclofenac (10 mg/kg, i.p.) have been studied on a model of acute exudative inflammation induced by carrageenan in outbred rats and concanavalin A (Con A) in CBA mice. The level of cytokines was studied on the lipopolysaccharide (LPS) model (single administration, 100 mg/kg, i.p.) with 5-day administration of noopept at a dose of 5 mg/kg (i.p., before endotoxin injection) in C57BL/6 mice. The administration of noopept led to a significant suppression of the inflammatory response to both carrageenan and Con A. The administration of Con A caused a 16-fold increase in the level of IL-6 interleukin in the blood serum of mice as compared to control. Noopept (5 mg/kg) reduced the level of IL-6 by a factor of 1.8 in the inflammatory response to Con A. The administration of LPS led to pronounced increase in the levels ofpro-inflammatory IL-6 and TNF-alpha in the blood serum of test mice as compared to intact animals. The course administration of noopept (5 mg/kg) significantly decreased the level of IL-6 and reduced by half the level of TNF-alpha.
authors.forename: S V
authors.initials: SV
authors.lastname: Alekseeva
authors.forename: L P
authors.initials: LP
authors.lastname: Kovalenko
authors.forename: A V
authors.initials: AV
authors.lastname: Tallerova
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: A D
authors.initials: AD
authors.lastname: Durnev
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan / Q000633:toxicity; D003208:Concanavalin A / Q000009:adverse effects / Q000494:pharmacology; D016207:Cytokines / Q000097:blood*; D004008:Diclofenac / Q000493:pharmacokinetics; D004151:Dipeptides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000097:blood / Q000139:chemically induced; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008934:Mitogens / Q000009:adverse effects / Q000494:pharmacology; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D004151:Dipeptides; D008070:Lipopolysaccharides; D008934:Mitogens; D003208:Concanavalin A; D004008:Diclofenac; C103871:ethyl phenylacetyl-Pro-Gly; D002351:Carrageenan