title: Para-aminosalicylic acid plasma concentrations in children in comparison with adults after receiving a granular slow-release preparation.
abstract: There are no paediatric data regarding slow-release para-aminosalicylic acid (PAS). We studied PAS plasma concentrations in 10 children receiving a single 150 mg/kg dose daily or 75 mg/kg twice daily and 12 adults receiving 4 g twice daily. Blood specimens pre-dose and 2, 4, 6, 8 and 12 h post-dose from the children and 2, 3, 4, 5, 6, 8 and 12 h post-dose from the adults were analysed by high performance liquid chromatography MS/MS. The mean Cmax in children receiving PAS 75 mg/kg and 150 mg/kg and adults receiving 4 g was 45.40, 56.49 and 51.3 µg/ml, respectively (p = 0.614); the AUC0-12 was 233.3, 277.9 and 368.0 µg/h/ml (p = 0.587). No parameters differed significantly between children and adults nor between the two doses in the same children. A 150 mg/kg PAS dosage given as one or two daily doses leads to plasma concentrations in children similar to those of adults receiving 4 g PAS twice daily.
authors.affiliation: Division of Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa.
authors.forename: A C
authors.initials: AC
authors.lastname: Liwa
authors.forename: H S
authors.initials: HS
authors.lastname: Schaaf
authors.forename: B
authors.initials: B
authors.lastname: Rosenkranz
authors.forename: H I
authors.initials: HI
authors.lastname: Seifart
authors.forename: A H
authors.initials: AH
authors.lastname: Diacon
authors.forename: P R
authors.initials: PR
authors.lastname: Donald
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D010131:Aminosalicylic Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013019:South Africa; D053719:Tandem Mass Spectrometry; D014376:Tuberculosis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D003692:Delayed-Action Preparations; D010131:Aminosalicylic Acid