title: [The value of serum intestinal fatty acid binding protein measurement in discriminating intestinal ischemia in patients with acute abdomen].
abstract: OBJECTIVE
  To assess the differential diagnostic value of serum intestinal fatty acid binding protein (I-FABP) in distinguishing intestinal ischemia patients from acute abdomen patients.
  
  
  METHODS
  A total of 151 patients with acute abdomen and 17 healthy controls from the PLA General Hospital were enrolled from November, 2009 to August, 2011. Serum I-FABP levels were measured by ELISA. According to the ROC curve, the cut-off value, sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), positive predictive value (PPV) and negative predictive value (NPV) were calculated.
  
  
  RESULTS
  Of the 151 acute abdomen patients, there were 24 intestinal ischemia patients and 127 without intestinal ischemia. Serum I-FABP level in intestinal ischemia group [(109.67 ± 48.82) µg/L] was significantly higher than those in patients without intestinal ischemia [(36.78 ± 11.25) µg/L] and healthy controls[(8.33 ± 6.25) µg/L](all P values < 0.01). The serum I-FABP cut-off value for the diagnosis of intestinal ischemia was 87.52 µg/L. Serum I-FABP was efficient in terms of sensitivity (0.762), NPV(0.963), PLR(3.05) and NLR (0.24) in the diagnosis of intestinal ischemia.
  
  
  CONCLUSIONS
  I-FABP is potentially useful for discriminating intestinal ischemia from acute abdomen.
authors.affiliation: Department of Gastroenterology, Nanlou Division, the PLA General Hospital, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shi
authors.forename: Ben-yan
authors.initials: BY
authors.lastname: Wu
authors.forename: Wen-hui
authors.initials: WH
authors.lastname: Liu
authors.forename: Bin-bin
authors.initials: BB
authors.lastname: Su
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Li
mesh_terms: D000006:Abdomen, Acute / Q000097:blood / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D003937:Diagnosis, Differential; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D007422:Intestines / Q000098:blood supply / Q000503:physiopathology*; D007511:Ischemia / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D050556:Fatty Acid-Binding Proteins