title: Dysregulation of RNA polymerase I transcription during disease.
abstract: Transcription of the ribosomal RNA genes by the dedicated RNA polymerase I enzyme and subsequent processing of the ribosomal RNA are fundamental control steps in the synthesis of functional ribosomes. Dysregulation of Pol I transcription and ribosome biogenesis is linked to the etiology of a broad range of human diseases. Diseases caused by loss of function mutations in the molecular constituents of the ribosome, or factors intimately associated with RNA polymerase I transcription and processing are collectively termed ribosomopathies. Ribosomopathies are generally rare and treatment options are extremely limited tending to be more palliative than curative. Other more common diseases are associated with profound changes in cellular growth such as cardiac hypertrophy, atrophy or cancer. In contrast to ribosomopathies, altered RNA polymerase I transcriptional activity in these diseases largely results from dysregulated upstream oncogenic pathways or by direct modulation by oncogenes or tumor suppressors at the level of the RNA polymerase I transcription apparatus itself. Ribosomopathies associated with mutations in ribosomal proteins and ribosomal RNA processing or assembly factors have been covered by recent excellent reviews. In contrast, here we review our current knowledge of human diseases specifically associated with dysregulation of RNA polymerase I transcription and its associated regulatory apparatus, including some cases where this dysregulation is directly causative in disease. We will also provide insight into and discussion of possible therapeutic approaches to treat patients with dysregulated RNA polymerase I transcription. This article is part of a Special Issue entitled: Transcription by Odd Pols.
authors.affiliation: Oncogenic Signalling and Growth Control Program, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett St, Melbourne, Victoria 8006, Australia.
authors.forename: K M
authors.initials: KM
authors.lastname: Hannan
authors.forename: E
authors.initials: E
authors.lastname: Sanij
authors.forename: L I
authors.initials: LI
authors.lastname: Rothblum
authors.forename: R D
authors.initials: RD
authors.lastname: Hannan
authors.forename: R B
authors.initials: RB
authors.lastname: Pearson
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D012318:RNA Polymerase I / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000235:genetics / Q000378:metabolism; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism; D019474:Transcription Factors, TFIII / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D012335:RNA, Ribosomal; D012269:Ribosomal Proteins; D019474:Transcription Factors, TFIII; D012318:RNA Polymerase I