title: Clinicopathologic importance of women with squamous cell carcinoma cytology on Siriraj liquid-based cervical cytology.
abstract: OBJECTIVE
  The purposes of this study were to determine the prevalence and predictive value to detect significant neoplasia and invasive lesions, and to evaluate the correlation between clinical and histopathology of women with squamous cell carcinoma (SCCA) on Siriraj liquid-based cervical cytology (Siriraj-LBC).
  
  
  METHODS
  The computerized database of women who underwent Siriraj-LBC at Siriraj Hospital, Mahidol University from January 2007 to December 2010 were retrieved. The hospital records of women with SCCA cytology were reviewed.
  
  
  RESULTS
  The prevalence of SCCA cytology was 0.07%. A total of 86 women, mean age was 58.1 years. Sixty-one women (70.9%) were post-menopausal. Overall significant pathology and invasive gynecologic cancer were detected in 84 women (97.7%) and 71 women (82.5%), respectively. The positive predictive values for detection of significant neoplasia and invasive lesion were 97.7% and 82.6%, respectively. The cervical cancer was diagnosed in 69 women and among these 58 women were SCCA. Thirteen women (15.1%) had cervical intraepithelial neoplasia (CIN) 3 and two women (2.3%) had cervicitis. The sensitivity and specificity of colposcopy for cervical cancer detection in SCCA cytology were 83.3% and 75%, respectively. Median follow up period was 17.6 months and 64 patients were alive without cytologic abnormality.
  
  
  CONCLUSIONS
  The final histopathology of SCCA cytology in our populations demonstrated a wide variety, from cervicitis to invasive cancer and the most common diagnosis was invasive cervical cancer. Colposcopy with biopsy and/or endocervical curettage and loop electrosurgical excision procedure should be undertaken to achieve histologic diagnosis.
authors.affiliation: Gynecologic Oncology Division, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. irene_siriraj@yahoo.com
authors.forename: Irene
authors.initials: I
authors.lastname: Ruengkhachorn
authors.forename: Somsak
authors.initials: S
authors.lastname: Laiwejpithaya
authors.forename: Chairat
authors.initials: C
authors.lastname: Leelaphatanadit
authors.forename: Pattama
authors.initials: P
authors.lastname: Chaopotong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D003127:Colposcopy; D003581:Cytodiagnosis / Q000379:methods*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011237:Predictive Value of Tests; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000601:surgery