title: Anesthesia in patient with lead poisoning: case report.
abstract: OBJECTIVE
  Lead poisoning, also Saturnism, results from chronic lead poisoning, common after occupational exposure. Projectiles retained in the body may result in increased levels of plasma lead with numerous clinical implications, particularly neurological. We report a case of a symptomatic patient, undiagnosed, whose diagnosis was made during the preanesthesia evaluation.
  
  
  METHODS
  The patient was attended at our hospital to remove a bullet lodged in his left knee 14 years ago, presenting with polyneuropathy without investigation. During the preanesthetic visit, saturnism was hypothesized and confirmed by high plasma lead levels (129 μg.dL(-1)). Surgery was performed under general anesthesia before starting lead chelation. During anesthesia, the patient developed apnea, without chest-wall rigidity after administration of fentanyl (50 μg).
  
  
  CONCLUSIONS
  Lead poisoning interferes with the function of various organs and systems, alters oxidative metabolism and intracellular signaling mechanisms. Neurological involvement, with reduced neural conduction, deserves special attention from anesthesiologists.
authors.affiliation: ME(3), Centro de Ensino e Treinamento (CET/SBA), Hospital Universitário Antonio Pedro (Huap), Universidade Federal Fluminense (UFF), RJ, Brasil.
authors.forename: Luís Mauro Alvim
authors.initials: LM
authors.lastname: de Lima
authors.forename: Flávio Castro
authors.initials: FC
authors.lastname: Resende
authors.forename: Ana Carolina Janiques
authors.initials: AC
authors.lastname: dos Santos
authors.forename: Patricia Pimentel Duarte Rodrigues
authors.initials: PP
authors.lastname: Terra
authors.forename: Alberto Vieira
authors.initials: AV
authors.lastname: Pantoja
authors.forename: Marco Antonio Cardoso
authors.initials: MA
authors.lastname: de Resende
mesh_terms: D000328:Adult; D000758:Anesthesia / Q000379:methods*; D005547:Foreign Bodies / Q000150:complications / Q000601:surgery; D006801:Humans; D007855:Lead Poisoning / Q000209:etiology; D008297:Male; D014948:Wounds, Gunshot / Q000150:complications