title: Total synthesis of natural p-quinol cochinchinenone.
abstract: Cochinchinenone has been synthesized in only five steps and four pots and in 58% overall yield from commercially available 2,3-dimethoxy-4-hydroxy-benzaldehyde and OPMB-protected p-hydroxy acetophenone, the key step being the oxone-mediated oxidative dearomatization of the corresponding ketone-containing p-substituted phenol.
authors.affiliation: Departamento de Química Orgánica (Módulo 01), Facultad de Ciencias, Universidad Autónoma de Madrid, c/Francisco Tomás y Valiente 7, Cantoblanco, 28049-Madrid, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Barradas
authors.forename: Gloria
authors.initials: G
authors.lastname: Hernández-Torres
authors.forename: Antonio
authors.initials: A
authors.lastname: Urbano
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Carreño
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002384:Catalysis; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016480:Helicobacter pylori / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D047188:Chalcones; C578327:cochinchinenone