title: An efficient one-pot synthesis of pyrano[3,2-c]quinolin-2,5-dione derivatives catalyzed by L-proline.
abstract: A series of 4-aryl-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-2,5(6H)-diones were synthesized via the three-component reactions of aromatic aldehydes, 4-hydroxy-1-methylquinolin-2(1H)-one, and Meldrum's acid catalyzed by L-proline. The structures of the products were identified by spectroscopic analysis. A mechanism for this three-component reaction catalyzed by L-proline was proposed.
authors.affiliation: Key Laboratory of Biological Cancer Therapy of Jiangsu Province, Xuzhou Medical College, Xuzhou 221004, China. songleizhu@xzmc.edu.cn
authors.forename: Songlei
authors.initials: S
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Zhou
authors.initials: Z
authors.lastname: Xu
authors.forename: Jie
authors.initials: J
authors.lastname: Li
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D004146:Dioxanes / Q000737:chemistry; D006873:Hydroquinones / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry*; D015363:Quinolones / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000447:Aldehydes; D004146:Dioxanes; D006873:Hydroquinones; D011714:Pyrans; D015363:Quinolones; D011392:Proline; C076489:Meldrum's acid