title: Microfluidic tools for developmental studies of small model organisms--nematodes, fruit flies, and zebrafish.
abstract: Studying the genetics of development with small model organisms such as the zebrafish (Danio Rerio), the fruit fly (Drosophila melanogaster), and the soil-dwelling nematode (Caenorhabditis elegans), provide unique opportunities for understanding related processes and diseases in humans. These model organisms also have potential for use in drug discovery and toxicity-screening applications. There have been sweeping developments in microfabrication and microfluidic technologies for manipulating and imaging small objects, including small model organisms, which allow high-throughput quantitative biological studies. Here, we review recent progress in microfluidic tools able to manipulate small organisms and project future directions and applications of these techniques and technologies.
authors.affiliation: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
authors.forename: Hyundoo
authors.initials: H
authors.lastname: Hwang
authors.forename: Hang
authors.initials: H
authors.lastname: Lu
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans; D004331:Drosophila melanogaster; D055808:Drug Discovery; D047108:Embryonic Development; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods*; D023421:Models, Animal; D015027:Zebrafish