title: Raman detection of cell proliferation probes with antiresonance-guiding hollow fibers.
abstract: Antiresonance-guiding hollow-core fibers are shown to enable highly sensitive detection of cell proliferation probes using Raman scattering within the region where the cellular Raman activity is minimal. We demonstrate that such fibers can substantially reduce the level of the background compared to standard index-guiding optical fibers, thus radically improving the sensitivity of Raman detection of DNA synthesis in cells and offering a powerful tool for fiber-based live-cell imaging.
authors.affiliation: Physics Department, International Laser Center, M. V. Lomonosov Moscow State University, Moscow 119992, Russia.
authors.forename: Lyubov V
authors.initials: LV
authors.lastname: Doronina-Amitonova
authors.forename: Il'ya V
authors.initials: IV
authors.lastname: Fedotov
authors.forename: Andrei B
authors.initials: AB
authors.lastname: Fedotov
authors.forename: Konstantin V
authors.initials: KV
authors.lastname: Anokhin
authors.forename: Ming-lie
authors.initials: ML
authors.lastname: Hu
authors.forename: Ching-yue
authors.initials: CY
authors.lastname: Wang
authors.forename: Aleksei M
authors.initials: AM
authors.lastname: Zheltikov
mesh_terms: D049109:Cell Proliferation; D002470:Cell Survival; D055100:Optical Fibers; D055620:Optical Phenomena; D013059:Spectrum Analysis, Raman / Q000295:instrumentation*