title: Molecular diagnosis of infection-related cancers in dermatopathology.
abstract: The association between viruses and skin cancer is increasingly recognized in a number of neoplasms, that is, cutaneous squamous cell carcinoma, Kaposi sarcoma, nasopharyngeal carcinoma, and Merkel cell carcinoma, as well as hematolymphoid malignancies such as adult T-cell leukemia/lymphoma and NK/T-cell lymphoma (nasal type) and post-transplant lymphoproliferative disorders. Molecular assays are increasingly used to diagnose and manage these diseases. In this review, molecular features of tumor viruses and related host responses are explored. The tests used to identify such features are summarized. Evaluation of the utility of these assays for diagnosis and/or management of specific tumor types is presented.
authors.affiliation: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. pulitzem@mskcc.org
authors.forename: Melissa
authors.initials: M
authors.lastname: Pulitzer
mesh_terms: D015266:Carcinoma, Merkel Cell / Q000175:diagnosis / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000821:virology; D015490:HTLV-I Infections / Q000175:diagnosis / Q000821:virology; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000821:virology; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis / Q000821:virology; D008223:Lymphoma / Q000473:pathology / Q000821:virology; D015336:Molecular Probe Techniques; D027383:Papillomaviridae / Q000145:classification; D027601:Polyomavirus Infections / Q000175:diagnosis / Q000821:virology; D012192:Retroviridae Infections / Q000175:diagnosis / Q000821:virology; D012878:Skin Neoplasms / Q000473:pathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000821:virology