title: Uterine rupture during trial of labor: controversy of induction's methods.
abstract: The rate of attempted vaginal birth after cesarean has decreased during the past 15 years. Most of the change since the mid 1990s is the result of increasing reports of uterine rupture during trial of labor, with the highest rates related to labor induction. Not all induction agents have the same magnitude of increased risk of uterine rupture, and there have been only a small number of randomized controlled trials of labor induction in women with previous cesarean delivery. Evaluation of the evidence on specific methods of induction reveals that the lowest rate of uterine rupture occurs with oxytocin at 1.1% (95% confidence interval [CI], 0.9%-1.5%) then dinoprostone at 2% (95% CI, 1.1%-3.5%), and the highest rate is with misoprostol, 6% (95% CI, 0.74%-51.4%). We review the incidence of uterine rupture during induction of labor after previous cesarean and examine the methods of induction and the safety of different techniques for cervical ripening, induction, and/or augmentation of labor in women with previous cesarean delivery.
authors.affiliation: Maternal and Fetal Medicine Unit, Department of Obstetrics & Gynecology, Western Galilee Hospital, Nahariya, Israel. ella.ophir@naharia.health.gov.il
authors.forename: Ella
authors.initials: E
authors.lastname: Ophir
authors.forename: Marwan
authors.initials: M
authors.lastname: Odeh
authors.forename: Yael
authors.initials: Y
authors.lastname: Hirsch
authors.forename: Jacob
authors.initials: J
authors.lastname: Bornstein
mesh_terms: D015232:Dinoprostone / Q000009:adverse effects; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods*; D016595:Misoprostol / Q000009:adverse effects; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects*; D010121:Oxytocin / Q000009:adverse effects; D011247:Pregnancy; D012306:Risk; D014597:Uterine Rupture / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D016064:Vaginal Birth after Cesarean / Q000009:adverse effects* / Q000706:statistics & numerical data
chemical_list: D010120:Oxytocics; D016595:Misoprostol; D010121:Oxytocin; D015232:Dinoprostone