title: A mediator lost in the war on cancer.
abstract: An unexpected role for a Mediator subunit, MED12, in resistance to multiple anticancer agents is revealed by Huang et al. Loss of MED12 confers drug resistance by activating transforming growth factor b (TGF-b) signaling. Inhibition of the TGF-b pathway resensitizes cells to therapeutic drugs, suggesting a new combinatorial cancer treatment.
authors.affiliation: Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA. x4guo@ucsd.edu
authors.forename: Xing
authors.initials: X
authors.lastname: Guo
authors.forename: Xiao-Fan
authors.initials: XF
authors.lastname: Wang