title: Anti-H5N1 virus new diglyceride ester from the Red Sea grass Thallasodendron ciliatum.
abstract: Some Egyptian plants were screened against highly pathogenic avian influenza strain H5N1 using plaque inhibition assay in Madin-Darby canine kidney. The results indicated that the extracts of Red Sea grass Thallasodendron ciliatum possessed potent antiviral activity (100% inhibition at the concentration of 1 μg mL⁻¹). The bioactivity-guided fractionations led to the isolation of a new diglyceride ester (1) along with asebotin (2) for the first time from the plant. The two isolates showed reduction of virus titre by 67.26% and 53.81% inhibition at concentration of 1 ng mL⁻¹, respectively.
authors.affiliation: a Department of Pharmacognosy , Faculty of Pharmacy, Suez Canal University , 41522 , Ismailia , Egypt.
authors.forename: Amany K
authors.initials: AK
authors.lastname: Ibrahim
authors.forename: Ahmed I
authors.initials: AI
authors.lastname: Youssef
authors.forename: Abdel Satar
authors.initials: AS
authors.lastname: Arafa
authors.forename: Reda
authors.initials: R
authors.lastname: Foad
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Radwan
authors.forename: Samir
authors.initials: S
authors.lastname: Ross
authors.forename: Hashim A
authors.initials: HA
authors.lastname: Hassanean
authors.forename: Safwat A
authors.initials: SA
authors.lastname: Ahmed
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D004075:Diglycerides / Q000737:chemistry* / Q000494:pharmacology*; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D006109:Poaceae / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D004075:Diglycerides