title: Pelvic radiotherapy after renal transplantation.
abstract: BACKGROUND
  After renal transplantation, patients have a higher incidence of developing cancer necessitating pelvic radiotherapy, but there is a lack of data for such therapy in this patient group.
  
  
  METHODS
  Nine patients with pelvic renal transplants were treated with pelvic radiotherapy between 04/2002 and 06/2011. Treatment was carried out for prostate (n=4), rectal (n=2), and anal cancer (n=1), osseous metastasis (n=1), and Hodgkin's disease (n=1). The mean age of the transplants was 12.6 years.
  
  
  RESULTS
  The mean total dose to the target volume was 60.2 Gy, the mean maximum dose to the transplant was 10.0 Gy, with a mean dose of 2.1 Gy. The mean creatinine clearance before start of radiotherapy was 48.9 ml/min. After a mean follow-up of 23 months, no patient showed failure of the transplant and the mean creatinine clearance was 64.2 ml/min.
  
  
  CONCLUSIONS
  Using modern radiotherapy techniques, low doses to the transplant can be achieved without compromising target treatment and without transplant failure. A mean dose of <4 Gy seems to be well-tolerated by the graft.
authors.affiliation: Department of Radiation Oncology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Sören
authors.initials: S
authors.lastname: Dahlke
authors.forename: Anke
authors.initials: A
authors.lastname: Schwarz
authors.forename: Frank
authors.initials: F
authors.lastname: Bruns
authors.forename: Michael
authors.initials: M
authors.lastname: Bremer
authors.forename: Michael
authors.initials: M
authors.lastname: Miemietz
authors.forename: Hans
authors.initials: H
authors.lastname: Christiansen
authors.forename: Andreas
authors.initials: A
authors.lastname: Meyer
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy*; D010388:Pelvis / Q000528:radiation effects*; D011829:Radiation Dosage; D020266:Radiotherapy, Conformal / Q000379:methods*; D012189:Retrospective Studies