title: In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes.
abstract: We demonstrate the feasibility of mapping a sentinel lymph node (SLN) and urinary bladder by using modified single-walled carbon nanotubes (SWNTs) as a nonionizing photoacoustic (PA) contrast agent. To improve the PA sensitivity, indocyanine green (ICG) was conjugated with SWNTs and the optical absorption of SWNTs-ICG was enhanced by approximately four times compared to that of plain SWNTs at a concentration of 0.3 µM. In vivo PA imaging results showed that the SLN and bladder were clearly visualized due to accumulation of SWNTs-ICG. This implies that the SWNTs-ICG could be potentially utilized to identify SLNs in breast cancer patients and tracking vesicoureteral reflux in combination with PA imaging.
authors.affiliation: Department of Mechatronics Engineering, Pukyong National University, Busan 608-737, Korea.
authors.forename: Jasung
authors.initials: J
authors.lastname: Koo
authors.forename: Mansik
authors.initials: M
authors.lastname: Jeon
authors.forename: Yunok
authors.initials: Y
authors.lastname: Oh
authors.forename: Hyun Wook
authors.initials: HW
authors.lastname: Kang
authors.forename: Jeehyun
authors.initials: J
authors.lastname: Kim
authors.forename: Chulhong
authors.initials: C
authors.lastname: Kim
authors.forename: Junghwan
authors.initials: J
authors.lastname: Oh
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D003287:Contrast Media / Q000737:chemistry*; D005240:Feasibility Studies; D007208:Indocyanine Green / Q000737:chemistry*; D008198:Lymph Nodes / Q000473:pathology*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D061088:Photoacoustic Techniques / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D001743:Urinary Bladder / Q000473:pathology*
chemical_list: D003287:Contrast Media; D037742:Nanotubes, Carbon; D007208:Indocyanine Green