title: Imidapril provides a protective effect on pulmonary hypertension induced by low ambient temperature in broiler chickens.
abstract: OBJECTIVE
  The objective of this article is to explore the role of imidapril on pulmonary hypertension induced by low ambient temperature in broiler chickens.
  
  
  METHODS
  Ninety chickens were randomly divided into three groups (n = 30): a control group, a low-temperature group and an imidapril group. Chickens in the low-temperature group and imidapril group were exposed to low ambient temperature from 14 days of age until 45 days of age; chickens in the imidapril group were gavaged with imidapril 3 mg/kg once daily for 30 days. The pulmonary arterial pressure, main pulmonary arterial diameter and pulmonary arterial wall thickness were measured, and lung tissue ACE, ACE2 mRNA expression, proliferating cell nuclear antigen (PCNA)-positive cells and Ang II, Ang (1-7) concentration were evaluated.
  
  
  RESULTS
  The pulmonary arterial pressure was higher, the main pulmonary arterial diameter was wider and the pulmonary arterial wall was thicker in the low-temperature group than those in the control group and the imidapril group. ACE mRNA and PCNA-positive cells increased significantly in the low-temperature group compared with the control group and imidapril group; lung tissue Ang II concentration in the low-temperature group was higher, but Ang (1-7) content was lower than that in the control group and imidapril group.
  
  
  CONCLUSIONS
  Imidapril provides a protective effect on pulmonary hypertension induced by low ambient temperature in broiler chickens.
authors.affiliation: Department of Pharmacy, College of Animal Science and Technology, Henan University of Science and Technology, China.
authors.forename: Xue-Qin
authors.initials: XQ
authors.lastname: Hao
authors.affiliation: Department of Cardiology, Luoyang Central Hospital Affiliated to Zhengzhou University, China zsydoctor@163.com.
authors.forename: Shou-Yan
authors.initials: SY
authors.lastname: Zhang
authors.affiliation: Luoyang Entry-Exit Inspection and Quarantine Bureau, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Pharmacy, College of Animal Science and Technology, Henan University of Science and Technology, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: College of Food and Biology Engineering, Department of Biology Engineering, Henan University of Science and Technology, China.
authors.forename: Ming-Fu
authors.initials: MF
authors.lastname: Niu
authors.affiliation: Department of Integrated ICU, the First Affiliated Hospital of Zhengzhou University, China.
authors.forename: Tong-Wen
authors.initials: TW
authors.lastname: Sun
authors.affiliation: Department of Pharmacology, Zunyi Medical College, China.
authors.forename: Dan-Li
authors.initials: DL
authors.lastname: Yang
authors.affiliation: Department of Pharmacy, College of Animal Science and Technology, Henan University of Science and Technology, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Kong
authors.affiliation: Department of Pharmacy, College of Animal Science and Technology, Henan University of Science and Technology, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
mesh_terms: D000803:Angiotensin I / Q000378:metabolism; D000804:Angiotensin II / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D062186:Arterial Pressure; D002645:Chickens; D003080:Cold Temperature; D006976:Hypertension, Pulmonary / Q000517:prevention & control* / Q000662:veterinary*; D048289:Imidazolidines / Q000627:therapeutic use*; D008168:Lung / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D011201:Poultry Diseases / Q000517:prevention & control*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011651:Pulmonary Artery / Q000473:pathology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D048289:Imidazolidines; D010446:Peptide Fragments; D018809:Proliferating Cell Nuclear Antigen; D000804:Angiotensin II; D000803:Angiotensin I; C065166:imidapril; D007703:Peptidyl-Dipeptidase A; C118790:angiotensin I (1-7)