title: [Diagnostic and treatment patterns in management of male patients with nongonococcal urethritis: results of Russian multicentral cross-sectional study].
abstract: The aim of the study was to estimate the diagnostic and treatment patterns in the management of acute nongonococcal urethritis (NGU) in males in some cities of Russia. Retrospective cross-sectional study was conducted in 2009 in 5 centers of 4 cities in the Central Part of Russia (Kaluga, Pskov, Smolensk - 2 centres and Tula). The data on the diagnostic and treatment approaches to the management of NGU in male subjects >16 years old were collected and analyzed with the use of specially designed case report forms. 556 cases of acute urethritis were analyzed during the study. The diagnosis of NGU was confirmed in 401 cases. The average age of the patients was 29.8 years (16-68 years). The following diagnostic methods were used in 95% of the cases: urethral smear microscopy (314/82.4%), C. trachomatis - PCR (113/29.7%), ELISA (155/40.7%); T. vaginalis - PCR (106/27.8%); U. urealyricum and M. hominis, respectively - bacteriology (140/36.7% and 126/33.1%), PCR (110/28.9% and 108/28.3%); M. genitalium - PCR (110/28.9%). The treatment patterns included antimicrobials AMs alone in 60.3, and AMs + non-AMs in 37.8% of the cases. The most frequently prescribed AMs were azithromycin (27.5%), fluconazole (16.4%), doxycycline (13.6%), metronidazole (11.2%), ofloxacine (7.3%), ceftriaxone (4.4%), josamycin (4.2). According to the results use of the standard methods for NGU diagnosis was rather rare. The use of PCR for atypical pathogens was the following: C. trachomatis 29.7%, U. urealyticum 36.7%, M. hominis 28.9%, M. genitalium 28.3%. Doubtful culture methods were used for detection of U. urealyticum and M. hominis (36.7% and 33.1%). The AMs treatment in some cases was not in compliance with the up-to-date practical guidelines for STD and NGU.
authors.forename: I V
authors.initials: IV
authors.lastname: Andreeva
authors.forename: S N
authors.initials: SN
authors.lastname: Kozlov
authors.forename: S V
authors.initials: SV
authors.lastname: Korolev
authors.forename: A N
authors.initials: AN
authors.lastname: Belikov
authors.forename: A V
authors.initials: AV
authors.lastname: Grinev
authors.forename: V V
authors.initials: VV
authors.lastname: Evstaf'ev
authors.forename: N N
authors.initials: NN
authors.lastname: Kirpicheva
authors.forename: M V
authors.initials: MV
authors.lastname: Serdiutskaia
authors.forename: O U
authors.initials: OU
authors.lastname: Stetsiuk
authors.forename: A A
authors.initials: AA
authors.lastname: Fokin
authors.forename: A A
authors.initials: AA
authors.lastname: Khrianin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D003430:Cross-Sectional Studies; D004318:Doxycycline / Q000627:therapeutic use; D015725:Fluconazole / Q000627:therapeutic use; D019983:Guideline Adherence / Q000592:standards; D006801:Humans; D015570:Josamycin / Q000627:therapeutic use; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D045704:Mycoplasma genitalium / Q000302:isolation & purification; D019535:Mycoplasma hominis / Q000302:isolation & purification; D015242:Ofloxacin / Q000627:therapeutic use; D016133:Polymerase Chain Reaction / Q000379:methods; D017410:Practice Guidelines as Topic / Q000592:standards; D012189:Retrospective Studies; D012426:Russia; D014246:Trichomonas vaginalis / Q000302:isolation & purification; D016990:Ureaplasma urealyticum / Q000302:isolation & purification; D014521:Urethra / Q000382:microbiology; D014526:Urethritis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000981:Antiprotozoal Agents; D008795:Metronidazole; D002443:Ceftriaxone; D017963:Azithromycin; D015725:Fluconazole; D015242:Ofloxacin; D015570:Josamycin; D004318:Doxycycline