title: The emerging role of Interleukin 27 in inflammatory arthritis and bone destruction.
abstract: Although the causes of inflammatory arthritis elude us, aberrant cytokine expression has been linked to joint pathology. Consequently, several approaches in the clinic and/or in clinical trials are targeting cytokines, e.g. tumor necrosis factor (TNF), Interleukin 23 (IL-23) and Interleukin 17 (IL-17), with the goal of antagonizing their respective biologic activity through therapeutic neutralizing antibodies. Such, cytokine signaling-dependent molecular networks orchestrate synovial inflammation on multiple levels including differentiation of myeloid cells to osteoclasts, the central cellular players in arthritis-associated pathologic bone resorption. Hence, understanding of the cellular and molecular mechanisms elicited by synovial cytokine networks that dictate recruitment, differentiation and activation of osteoclast precursors and osteoclasts, respectively, is central to shaping novel therapeutic options for inflammatory arthritis patients. In this article we are discussing the complex signaling interactions involved in the regulation of inflammatory arthritis and it's associated bone loss with a focus on Interleukin 27 (IL-27). The present review will discuss the primary bone-degrading cell, the osteoclast, and on how IL-27, directly or indirectly, modulates osteoclast activity in autoimmune-driven inflammatory joint diseases.
authors.affiliation: Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California at Davis and Institute of Pediatric and Regenerative Medicine, Shriners Hospital for Children, Sacramento, CA 95817, USA. iannis@ucdmc.ucdavis.edu
authors.forename: Iannis E
authors.initials: IE
authors.lastname: Adamopoulos
authors.forename: Stefan
authors.initials: S
authors.lastname: Pflanz
mesh_terms: D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001862:Bone Resorption / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D010010:Osteoclasts / Q000276:immunology; D018123:Receptors, Interleukin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: C112441:IL27RA protein, human; D020381:Interleukin-17; D018123:Receptors, Interleukin