title: Intelligent, self-powered, drug delivery systems.
abstract: Self-propelled nano/micromotors and pumps are considered to be next generation drug delivery systems since the carriers can either propel themselves ("motor"-based drug delivery) or be delivered ("pump"-based drug delivery) to the target in response to specific biomarkers. Recently, there has been significant advancement towards developing nano/microtransporters into proof-of-concept tools for biomedical applications. This review encompasses the progress made to date on the design of synthetic nano/micromotors and pumps with respect to transportation and delivery of cargo at specific locations. Looking ahead, it is possible to imagine a day when intelligent machines navigate through the human body and perform challenging tasks.
authors.affiliation: Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Debabrata
authors.initials: D
authors.lastname: Patra
authors.forename: Samudra
authors.initials: S
authors.lastname: Sengupta
authors.forename: Wentao
authors.initials: W
authors.lastname: Duan
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Ryan
authors.initials: R
authors.lastname: Pavlick
authors.forename: Ayusman
authors.initials: A
authors.lastname: Sen
mesh_terms: D004343:Drug Implants / Q000008:administration & dosage / Q000737:chemistry*; D004360:Drug Therapy, Computer-Assisted / Q000295:instrumentation*; D004867:Equipment Design; D015918:Infusion Pumps, Implantable; D009038:Motion; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation*; D012371:Robotics / Q000295:instrumentation*
chemical_list: D004343:Drug Implants; D053769:Nanocapsules