title: Elaiomycins K and L, new azoxy antibiotics from Streptomyces sp. Tü 6399*.
abstract: Elaiomycins K and L, two new azoxy-type antibiotics, were detected by HPLC-diode array screening in the culture filtrate extract of Streptomyces sp. Tü 6399. The structures were determined by high-resolution MS and 2-dimensional (1)H and (13)C correlated NMR spectroscopy including (15)N-NMR experiments and established these compounds as new members of the elaiomycin family. Both metabolites show a weak antibacterial activity against Bacillus subtilis and Staphylococcus lentus as well as against the phytophathogenic strain Xanthomonas campestris.
authors.affiliation: Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany.
authors.forename: Niko
authors.initials: N
authors.lastname: Manderscheid
authors.forename: Soleiman E
authors.initials: SE
authors.lastname: Helaly
authors.forename: Andreas
authors.initials: A
authors.lastname: Kulik
authors.forename: Jutta
authors.initials: J
authors.lastname: Wiese
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001391:Azo Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects; D013302:Streptomyces / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D016959:Xanthomonas campestris / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001391:Azo Compounds; C013979:elaiomycin