title: Histone variants and transcription regulation.
abstract: Histones are the protein components of chromatin and are important for its organization and compaction. Although core histones are exclusively expressed during S phase of the cell cycle, there exist variants of canonical histones that are expressed throughout the cell cycle. These histone variants are often deposited at defined regions of the genome and they play important roles in a variety of cellular processes, such as transcription regulation, heterochromatin formation and DNA repair. In this chapter, we will focus on several histone variants that have been linked to transcription regulation, and highlight their physical and functional features that facilitate their activities in this context.
authors.affiliation: Ontario Cancer Institute, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.
authors.forename: Cindy
authors.initials: C
authors.lastname: Law
authors.forename: Peter
authors.initials: P
authors.lastname: Cheung
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D005786:Gene Expression Regulation; D014644:Genetic Variation; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D012313:RNA / Q000096:biosynthesis*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D012313:RNA