title: Adjuvant pelvic irradiation for cervical cancer in the setting of a transplanted pelvic kidney.
abstract: Postoperative radiation therapy is often needed following resection for gynecological cancers. A pelvic kidney, whether ectopic or transplanted, is considered an absolute contraindication for radiation if the organ is left in place. A 45-year-old, immunosuppressed patient with FIGO IB1 cervical adenocarcinoma was treated with intensity-modulated radiation therapy (IMRT) to 45 Gy to the modified whole pelvis with a boost to 59.4 Gy to high-risk areas despite having a transplanted kidney in the right iliac fossa. The irradiation prevented further local failure in the pelvis at 36-month follow-up with no decrement in renal function. Radiation to the modified pelvis using IMRT while avoiding the renal allograft is technically feasible and should be offered to more high-risk patients.
authors.affiliation: Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. majid.mohiuddin.md@gmail.com
authors.forename: Majid M
authors.initials: MM
authors.lastname: Mohiuddin
authors.forename: Usama
authors.initials: U
authors.lastname: Mahmood
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Hall
authors.forename: Neil
authors.initials: N
authors.lastname: Rosenshein
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007668:Kidney / Q000528:radiation effects* / Q000601:surgery; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008875:Middle Aged; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*