title: Applications of asymmetric organocatalysis in medicinal chemistry.
abstract: In the last decade, organocatalysis, the use of small chiral organic molecules as catalysts, has proven to be a valuable and attractive tool for the synthesis of enantiomerically enriched molecules. A number of organocatalysts and processes, such as one-pot, tandem, cascade or multicomponent reactions, have been reported to date. Furthermore, the many advantages of organocatalysis - robust, non-toxic, affordable, inert atmosphere, easy reaction manipulation, etc. - allow the preparation of bioactive compounds using simple and metal-free procedures, thus avoiding false positives in the biological evaluation. This mini-review focuses on medicinal chemistry programs that have synthesized biologically active compounds using one or more organocatalytic steps. In this respect, the potential of organocatalytic methods for enabling the chemical synthesis of important medicinal targets will be highlighted.
authors.affiliation: Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, Francisco Tomás y Valiente 7, 28049-Madrid, Spain. jose.aleman@uam.es
authors.forename: José
authors.initials: J
authors.lastname: Alemán
authors.forename: Silvia
authors.initials: S
authors.lastname: Cabrera
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D000977:Antiparasitic Agents / Q000138:chemical synthesis / Q000737:chemistry; D058633:Antipyretics / Q000138:chemical synthesis / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D000977:Antiparasitic Agents; D058633:Antipyretics; D000998:Antiviral Agents; D018696:Neuroprotective Agents; D009930:Organic Chemicals; D004364:Pharmaceutical Preparations