title: Novel functions for Rab GTPases in multiple aspects of tumour progression.
abstract: Rab GTPases are master regulators of intracellular trafficking and, in recent years, their role in the control of different aspects of tumour progression has emerged. In the present review, we show that Rab GTPases are disregulated in many cancers and have central roles in tumour cell migration, invasion, proliferation, communication with stromal cells and the development of drug resistance. As a consequence, Rab proteins may be novel potential candidates for the development of anticancer drugs and, in this context, the preliminary results obtained with an inhibitor of Rab function are also discussed.
authors.affiliation: Molecular Medicine Section, National Heart and Lung Institute (NHLI), Imperial College London, London SW7 2AZ, UK. c.recchi@imperial.ac.uk
authors.forename: Chiara
authors.initials: C
authors.lastname: Recchi
authors.forename: Miguel C
authors.initials: MC
authors.lastname: Seabra
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002465:Cell Movement; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D021381:Protein Transport; D015398:Signal Transduction; D020691:rab GTP-Binding Proteins / Q000502:physiology*
chemical_list: D020691:rab GTP-Binding Proteins