title: Phenolic compounds and interaction between aminoglycosides and natural products of Lygodium venustum SW against multiresistant bacteria.
abstract: BACKGROUND
  The aim of this work was to evaluate the interactions between aminoglycosides and the ethyl-acetate fraction of the fern Lygodium venustum SW (EAFLV) METHODS: The ethyl-acetate fraction was obtained from the ethanol extract of L. venustum and was assayed via the checkerboard method associated with aminoglycosides against two bacterial strains multiresistant to antibiotics.
  
  
  RESULTS
  The antibiotic activity of all drugs, when associated with the ethyl-acetate fraction, was enhanced in an additive manner, except for the association between EAFLV and amikacin, which showed a synergistic interaction against the Escherichia coli strain.
  
  
  CONCLUSIONS
  The results indicated that L. venustum can be a source of secondary metabolites to be used in association with antibiotics like aminoglycosides in antibiotic chemotherapy against resistant bacteria.
authors.affiliation: Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, Brazil.
authors.forename: M F B
authors.initials: MF
authors.lastname: Morais-Braga
authors.forename: T M
authors.initials: TM
authors.lastname: Souza
authors.forename: K K A
authors.initials: KK
authors.lastname: Santos
authors.forename: G M M
authors.initials: GM
authors.lastname: Guedes
authors.forename: J C
authors.initials: JC
authors.lastname: Andrade
authors.forename: S R
authors.initials: SR
authors.lastname: Tintino
authors.forename: C E
authors.initials: CE
authors.lastname: Sobral-Souza
authors.forename: J G M
authors.initials: JG
authors.lastname: Costa
authors.forename: A A F
authors.initials: AA
authors.lastname: Saraiva
authors.forename: H D M
authors.initials: HD
authors.lastname: Coutinho
mesh_terms: D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D029624:Ferns / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001688:Biological Products; D010636:Phenols; D010936:Plant Extracts; D000583:Amikacin