title: The biochemical aspects of a non-ST-segment elevation acute coronary syndrome.
abstract: The clinical course of an acute coronary syndrome can vary from relatively benign         to potentially fatal. The biomarkers of myocardial necrosis relate to the amount of         myocardial damage and are closely linked to a patient's prognosis. They are measured         to help guide management decisions. Recent interest in myocardial neurohumoral         mechanisms has identified the natriuretic peptides as strong prognostic biomarkers         following an ischemic event. During an acute event they provide information regarding         the area of myocardium at risk. The biomarkers of inflammation, such as C-reactive         protein, are related to both the development of atherosclerosis and the risk of acute         ischemic events. The mechanism characterizing the pathophysiology of the syndrome is         represented by these cardiac biomarkers. Assessing combinations of pathobiologically         diverse biomarkers may provide a better risk evaluation method and further dictate         subsequent therapy.
authors.affiliation: Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Riezebos
authors.forename: Freek W A
authors.initials: FW
authors.lastname: Verheugt
authors.forename: Gerrit J
authors.initials: GJ
authors.lastname: Laarman
authors.forename: Jan G P
authors.initials: JG
authors.lastname: Tijssen
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D003661:Decision Support Techniques; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D045265:Natriuretic Peptides / Q000097:blood; D009336:Necrosis; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014336:Troponin / Q000097:blood
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D018836:Inflammation Mediators; D045265:Natriuretic Peptides; D014336:Troponin; D002097:C-Reactive Protein