title: Bilayered Raman-intense gold nanostructures with hidden tags (BRIGHTs) for high-resolution bioimaging.
abstract: Conventional SERS probes suffer from limited brightness and poor reproducibility and stability making them unsuitable for routine in vivo applications. A novel class of layered SERS probes is demonstrated in which individual nanostructures host electromagnetic hotspots, thus increasing brightness by more than two orders magnitude compared to conventional individual nanostructures.
authors.affiliation: Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, 1 Brookings Dr., St. Louis, MO 63130, USA.
authors.forename: Naveen
authors.initials: N
authors.lastname: Gandra
authors.forename: Srikanth
authors.initials: S
authors.lastname: Singamaneni
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D013059:Spectrum Analysis, Raman
chemical_list: D006046:Gold; D000644:Quaternary Ammonium Compounds; D018719:Erb-b2 Receptor Tyrosine Kinases; C521669:cetyl ammonium bromide; C508053:ERBB2 protein, human