title: Beyond steroidogenesis: novel target genes for SF-1 discovered by genomics.
abstract: Steroidogenic Factor-1 (SF-1) is a nuclear receptor transcription factor that has an essential role in the development of adrenal glands and gonads and in the regulation of steroidogenic gene expression. Recent studies using genomic approaches have revealed that SF-1 also has an important role in regulating proliferation of adrenocortical cells and have revealed its role in the control of a variety of biological processes as diverse as angiogenesis, adhesion to the extracellular matrix, cytoskeleton dynamics, transcriptional and post-transcriptional regulation of gene expression and apoptosis in the adrenal cortex. The identification of the complete set of SF-1 target genes will be of great importance to open new avenues for therapeutic intervention in adrenal diseases.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, UMR 7275, Valbonne, France. ninino@ipmc.cnrs.fr
authors.forename: Enzo
authors.initials: E
authors.lastname: Lalli
authors.forename: Mabrouka
authors.initials: M
authors.lastname: Doghman
authors.forename: Perle
authors.initials: P
authors.lastname: Latre de Late
authors.forename: Abeer
authors.initials: A
authors.lastname: El Wakil
authors.forename: Isabelle
authors.initials: I
authors.lastname: Mus-Veteau
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism*; D000306:Adrenal Cortex Neoplasms / Q000235:genetics; D017209:Apoptosis / Q000235:genetics; D002448:Cell Adhesion; D049109:Cell Proliferation; D005109:Extracellular Matrix / Q000235:genetics / Q000378:metabolism; D018628:Gene Dosage; D005786:Gene Expression Regulation; D023281:Genomics; D006066:Gonads / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D018919:Neovascularization, Physiologic / Q000235:genetics; D054339:Steroidogenic Factor 1 / Q000235:genetics / Q000378:metabolism*; D013256:Steroids / Q000096:biosynthesis
chemical_list: C531888:MIRN125 microRNA, human; D035683:MicroRNAs; C515057:NR5A1 protein, human; D054339:Steroidogenic Factor 1; D013256:Steroids