title: Pierre Robin sequence and Treacher Collins hypoplastic mandible comparison using three-dimensional morphometric analysis.
abstract: Pierre Robin sequence and Treacher Collins syndrome are both associated with mandibular hypoplasia. It has been hypothesized, however, that the mandible may be differentially affected. The purpose of this study was to therefore compare mandibular morphology in children with Pierre Robin sequence with children with Treacher Collins syndrome using three-dimensional analysis of computed tomographic scans. A retrospective analysis was performed identifying children with Pierre Robin sequence and Treacher Collins syndrome undergoing computed tomography. Three-dimensional reconstruction was performed, and ramus height, mandibular body length, and gonial angle were measured. These were then compared with those in control children with normal mandibles and with the clinical norms corrected for age and sex based on previously published measurements. Mandibular body length was found to be significantly shorter for children with Pierre Robin sequence, whereas ramus height was significantly shorter for children with Treacher Collins syndrome. This resulted in distinctly different ramus height-mandibular body length ratios. In addition, the gonial angle was more obtuse in both the Pierre Robin sequence and Treacher Collins syndrome groups compared with the controls. Three-dimensional mandibular morphometric analysis in patients with Pierre Robin sequence and Treacher Collins syndrome thus revealed distinctly different patterns of mandibular hypoplasia relative to normal controls. These findings underscore distinct considerations that must be made in surgical planning for reconstruction.
authors.affiliation: Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, CA 94305, USA
authors.forename: Michael T
authors.initials: MT
authors.lastname: Chung
authors.forename: Benjamin
authors.initials: B
authors.lastname: Levi
authors.forename: Jeong S
authors.initials: JS
authors.lastname: Hyun
authors.forename: David D
authors.initials: DD
authors.lastname: Lo
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Montoro
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Lisiecki
authors.forename: James P
authors.initials: JP
authors.lastname: Bradley
authors.forename: Steven R
authors.initials: SR
authors.lastname: Buchman
authors.forename: Michael T
authors.initials: MT
authors.lastname: Longaker
authors.forename: Derrick C
authors.initials: DC
authors.lastname: Wan
mesh_terms: D002508:Cephalometry / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D002680:Chin / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007231:Infant, Newborn; D008297:Male; D008334:Mandible / Q000002:abnormalities* / Q000000981:diagnostic imaging; D008335:Mandibular Condyle / Q000000981:diagnostic imaging; D008342:Mandibulofacial Dysostosis / Q000000981:diagnostic imaging*; D010347:Patient Care Planning; D010855:Pierre Robin Syndrome / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*