title: Synthesis, crystal structure, DNA binding and in vitro biological studies of Ni(II), Cu(II) and Zn(II) complexes of N-phthaloylglycine.
abstract: Ni(II), Cu(II) and Zn(II) metal complexes of N-phthaloylglycine were synthesized, characterized, reported for single crystal X-ray diffraction analysis for Ni(II) complex, and investigated for their binding with DNA under physiological conditions, using spectroscopic (UV-visible and fluorescence) and hydrodynamic techniques. Experimental results from both spectroscopic methods were comparable and further supported by viscosity measurements. Binding constant "K(b)" obtained from both spectroscopic methods revealed significant binding of compounds with DNA via intercalation. Among all compounds comparatively good DNA binding was found for Zn(II) complex. Free energies of compounds-DNA interactions indicated spontaneity of their binding. Dynamic and bimolecular enhancement values disclose static process involved in compounds-DNA complex formation. All compounds exhibited broad range antibacterial, while Zn(II) complex exhibited best antitumor activity.
authors.affiliation: Department of Chemistry, Allama Iqbal Open University, Islamabad, Pakistan. nasimaa2006@yahoo.com
authors.forename: Nasima
authors.initials: N
authors.lastname: Arshad
authors.forename: Naeem
authors.initials: N
authors.lastname: Abbas
authors.forename: Moazzam H
authors.initials: MH
authors.lastname: Bhatti
authors.forename: Naghmana
authors.initials: N
authors.lastname: Rashid
authors.forename: Muhammad Nawaz
authors.initials: MN
authors.lastname: Tahir
authors.forename: Samreen
authors.initials: S
authors.lastname: Saleem
authors.forename: Bushra
authors.initials: B
authors.lastname: Mirza
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001681:Biological Assay; D001713:Biphenyl Compounds / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry; D013696:Temperature; D015032:Zinc / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D009942:Organometallic Compounds; D010851:Picrates; C008899:N-phthalylglycine; D003300:Copper; D009532:Nickel; D004247:DNA; C004931:1,1-diphenyl-2-picrylhydrazyl; D015032:Zinc; D005998:Glycine