title: Cell polarity and cystic kidney disease.
abstract: Epithelial cell polarity is essential for organ development; aberrations in this process have been implicated in various diseases, including polycystic kidney disease. Establishment and maintenance of cell polarity is governed by a number of molecular processes and how these processes operate remains an interesting question. Conserved protein complexes guide both apical-basolateral polarity and planar cell polarity. In this review we discuss the recent findings that provide insights into polarity mechanisms and the intriguing crosstalk between apical-basolateral polarity and planar cell polarity, and their relationship to cystic kidney disease.
authors.affiliation: Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, P.O. Box 208029, 333 Cedar Street, New Haven, CT 06520-8029, USA.
authors.forename: Sorin
authors.initials: S
authors.lastname: Fedeles
authors.forename: Anna Rachel
authors.initials: AR
authors.lastname: Gallagher
mesh_terms: D000818:Animals; D016764:Cell Polarity; D002923:Cilia / Q000378:metabolism / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism / Q000473:pathology; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D052177:Kidney Diseases, Cystic / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction