title: Effect of aging on metabolic pathways in endothelial progenitor cells.
abstract: Age represents a significant risk factor for the onset and progression of cardiovascular disease, with the increase in life expectancy in developed countries going in parallel with increased incidence of such pathologies. Treatment strategies alternative or additive to pharmacological treatments are needed. The relationship between aging and progenitor cell-mediated repair is of great interest. Endothelial progenitor cells (EPC) mediate repair mechanisms for endothelial regeneration and maintenance, but they are subject to age-associated changes affecting negatively their number and/or function. Aim of this review is to examine the impact of age on EPC-mediated vascular repair, with a focus on the metabolic pathways involved and on the therapeutic targets with potential for attenuating this effect.
authors.affiliation: Cardiac, Thoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy. francescadi@hotmail.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Felice
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Barsotti
authors.forename: Pavel
authors.initials: P
authors.lastname: Poredos
authors.forename: Alberto
authors.initials: A
authors.lastname: Balbarini
authors.forename: Rossella
authors.initials: R
authors.lastname: Di Stefano
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D004727:Endothelium / Q000378:metabolism*; D006801:Humans; D018919:Neovascularization, Physiologic; D013234:Stem Cells / Q000378:metabolism*