title: Dual nucleophilic/electrophilic capture of in situ generated iminium ethers: towards the synthesis of functionalized amide building blocks.
abstract: Rearranging its feathers: The transformation of simple linear amides into a diverse range of branched, functionalized products by conversion to iminium esters is followed by sequential treatment with nucleophiles and electrophiles (see scheme). The method takes advantage of a novel Claisen rearrangement and the use of aromatic substrates greatly facilitates the formation of the intermediate iminium ether.
authors.affiliation: Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
authors.forename: Bo
authors.initials: B
authors.lastname: Peng
authors.forename: Daniel H
authors.initials: DH
authors.lastname: O'Donovan
authors.forename: Igor D
authors.initials: ID
authors.lastname: Jurberg
authors.forename: Nuno
authors.initials: N
authors.lastname: Maulide