title: Decrease in RNA folding cooperativity by deliberate population of intermediates in RNA G-quadruplexes.
abstract: Keeping a broad (RNA) perspective: conventional biochemical detection systems only have a 100-fold linear response range. The range of potassium concentrations detected by an RNA G-quadruplex sequence can be broadened by intentionally populating multiple intermediate folding states. The folding of the RNA G-quadruplexes was monitored by both circular dichroism and intrinsic fluorescence spectroscopy.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park, 16802, USA.
authors.forename: Chun Kit
authors.initials: CK
authors.lastname: Kwok
authors.forename: Madeline E
authors.initials: ME
authors.lastname: Sherlock
authors.forename: Philip C
authors.initials: PC
authors.lastname: Bevilacqua
mesh_terms: D054856:G-Quadruplexes; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D059370:RNA Folding; D013050:Spectrometry, Fluorescence
chemical_list: D012313:RNA