title: INTERBED: internet-based guided self-help for overweight and obese patients with full or subsyndromal binge eating disorder. A multicenter randomized controlled trial.
abstract: BACKGROUND
  Binge eating disorder (BED) is a prevalent clinical eating disorder associated with increased psychopathology, psychiatric comorbidity, overweight and obesity, and increased health care costs. Since its inclusion in the DSM-IV, a few randomized controlled trials (RCTs) have suggested efficacy of book-based self-help interventions in the treatment of this disorder. However, evidence from larger RCTs is needed. Delivery of self-help through new technologies such as the internet should be investigated in particular, as these approaches have the potential to be more interactive and thus more attractive to patients than book-based approaches. This study will evaluate the efficacy of an internet-based guided self-help program (GSH-I) and cognitive-behavioral therapy (CBT), which has been proven in several studies to be the gold standard treatment for BED, in a prospective multicenter randomized trial.
  
  
  METHODS
  The study assumes the noninferiority of GSH-I compared to CBT. Both treatments lasted 4 months, and maintenance of outcome will be assessed 6 and 18 months after the end of treatment. A total of 175 patients with BED and a body mass index between 27 and 40 kg/m2 were randomized at 7 centers in Germany and Switzerland. A 20% attrition rate was assumed. As in most BED treatment trials, the difference in the number of binge eating days over the past 28 days is the primary outcome variable. Secondary outcome measures include the specific eating disorder psychopathology, general psychopathology, body weight, quality of life, and self-esteem. Predictors and moderators of treatment outcome will be determined, and the cost-effectiveness of both treatment conditions will be evaluated.
  
  
  RESULTS
  The methodology for the INTERBED study has been detailed.
  
  
  CONCLUSIONS
  Although there is evidence that CBT is the first-line treatment for BED, it is not widely available. As BED is still a recent diagnostic category, many cases likely remain undiagnosed, and a large number of patients either receive delayed treatment or never get adequate treatment. A multicenter efficacy trial will give insight into the efficacy of a new internet-based guided self-help program and will allow a direct comparison to the evidence-based gold standard treatment of CBT in Germany.
  
  
  BACKGROUND
  Current Controlled Trials ISRCTN40484777. German Clinical Trial Register DRKS00000409.
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany. dezwaan.martina@mh-hannover.de
authors.forename: Martina
authors.initials: M
authors.lastname: de Zwaan
authors.forename: Stephan
authors.initials: S
authors.lastname: Herpertz
authors.forename: Stephan
authors.initials: S
authors.lastname: Zipfel
authors.forename: Brunna
authors.initials: B
authors.lastname: Tuschen-Caffier
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Friederich
authors.forename: Frauke
authors.initials: F
authors.lastname: Schmidt
authors.forename: Olaf
authors.initials: O
authors.lastname: Gefeller
authors.forename: Andreas
authors.initials: A
authors.lastname: Mayr
authors.forename: Tony
authors.initials: T
authors.lastname: Lam
authors.forename: Carmen
authors.initials: C
authors.lastname: Schade-Brittinger
authors.forename: Anja
authors.initials: A
authors.lastname: Hilbert
mesh_terms: D056912:Binge-Eating Disorder / Q000175:diagnosis / Q000191:economics / Q000523:psychology / Q000628:therapy*; D002985:Clinical Protocols; D015928:Cognitive Behavioral Therapy / Q000191:economics; D003362:Cost-Benefit Analysis; D005247:Feeding Behavior; D005858:Germany; D017048:Health Care Costs; D006801:Humans; D020407:Internet / Q000191:economics; D009765:Obesity / Q000175:diagnosis / Q000191:economics / Q000523:psychology / Q000628:therapy*; D050177:Overweight / Q000175:diagnosis / Q000191:economics / Q000523:psychology / Q000628:therapy*; D011446:Prospective Studies; D012107:Research Design; D013557:Switzerland; D013813:Therapy, Computer-Assisted / Q000191:economics; D013997:Time Factors; D016896:Treatment Outcome