title: [Chromosomal integration of the sixth human herpes virus (HHV-6)].
abstract: Two closely related and commonly found human herpesviruses HHV-6 A and HHV-6 B are classified into the sixth human herpes virus complex (HHV-6). Primary infection with HHV-6 often takes place in early childhood and it can be either asymptomatic or manifests itself as sixth disease (caused by HHV-6 B). HHV-6 remains present in a latent form in the body with the potential for virus reactivation. The article points out the phenomenon of chromosomal integration of HHV-6 (Ci-HHV-6) which is found in about 1% of the population and, unlike the commonly spread HHV-6 infection, has become hereditary, with its pathological potential in Ci-HHV-6 DNA carriers remaining unknown. Therefore, the focus on clinical consequences of Ci-HHV-6 is of high relevance to the therapeutic strategy for patients with high HHV-6 positivity in molecular biological tests.
authors.affiliation: Ustav lékarské mikrobiologie 2. lékarské fakulty UK a Fakultní nemocnice v Motole. petr.hubacek@lfmotol.cuni.cz
authors.forename: Petr
authors.initials: P
authors.lastname: Hubácek
authors.forename: Alena
authors.initials: A
authors.lastname: Hrdlicková
authors.forename: Miroslav
authors.initials: M
authors.lastname: Zajac
mesh_terms: D002353:Carrier State / Q000821:virology; D005077:Exanthema Subitum / Q000175:diagnosis / Q000235:genetics / Q000628:therapy / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000235:genetics*; D006801:Humans; D016662:Virus Integration / Q000235:genetics*