title: African swine fever virus controls the host transcription and cellular machinery of protein synthesis.
abstract: Throughout a viral infection, the infected cell reprograms the gene expression pattern in order to establish a satisfactory antiviral response. African swine fever virus (ASFV), like other complex DNA viruses, sets up a number of strategies to evade the host's defense systems, such as apoptosis, inflammation and immune responses. The capability of the virus to persist in its natural hosts and in domestic pigs, which recover from infection with less virulent isolates, suggests that the virus displays effective mechanisms to escape host defense systems. ASFV has been described to regulate the activation of several transcription factors, thus regulating the activation of specific target genes during ASFV infection. Whereas some reports have concerned about anti-apoptotic ASFV genes and the molecular mechanisms by which ASFV interferes with inducible gene transcription and immune evasion, less is yet known regarding how ASFV regulates the translational machinery in infected cells, although a recent report has shown a mechanism for favored expression of viral genes based on compartmentalization of viral mRNA and ribosomes with cellular translation factors within the virus factory. The viral mechanisms involved both in the regulation of host genes transcription and in the control of cellular protein synthesis are summarized in this review.
authors.affiliation: Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
authors.forename: Elena G
authors.initials: EG
authors.lastname: Sánchez
authors.forename: Ana
authors.initials: A
authors.lastname: Quintas
authors.forename: Marisa
authors.initials: M
authors.lastname: Nogal
authors.forename: Alfredo
authors.initials: A
authors.lastname: Castelló
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Revilla
mesh_terms: D000358:African Swine Fever Virus / Q000502:physiology*; D000818:Animals; D054884:Host-Pathogen Interactions; D057131:Immune Evasion; D014176:Protein Biosynthesis; D013552:Swine; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000096:biosynthesis*; D014779:Virus Replication
chemical_list: D014764:Viral Proteins