title: [A case of advanced gastric cancer with multiple bone metastases and disseminated intravascular coagulation successfully treated by combination chemotherapy of S-1 plus docetaxel].
abstract: Advanced gastric cancer (AGC) accompanied by disseminated intravascular coagulation(DIC)has a poor prognosis, and has no established therapy. Here, we report a case of a 69-year-old woman referred to our hospital due to severe anemia and thrombocytopenia. Esophagogastroduodenoscopy demonstrated an AGC in the cardiac part of the stomach, which was histologically diagnosed as poorly-differentiated adenocarcinoma. Bone scintigraphy showed multiple metastases to the bone marrow. Her diagnosis was DIC resulting from AGC, with multiple bone metastases. She underwent chemotherapy with the following regimen: 60mg/m2 docetaxel(DOC)infusion on day 1 and daily oral administration of 100 mg/m2 S-1 for two weeks every three weeks. DIC subsided rapidly after initiation of the therapy and resolved in 12 days. She was discharged from the hospital 56 days after admission and survived 303 days. To our knowledge, this is the first case of AGC reported in the Japanese and English literature to obtain long-term survival in this setting. Combined chemotherapy of S-1 plus DOC may play an important role in the treatment of AGC developing DIC.
authors.affiliation: Dept. of Internal Medicine, Chugoku Central Hospital.
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Ninomiya
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Mannami
authors.forename: Satoru
authors.initials: S
authors.lastname: Seno
authors.forename: Yuko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Tomoki
authors.initials: T
authors.lastname: Tamura
authors.forename: Kosuke
authors.initials: K
authors.lastname: Kimura
authors.forename: Toshio
authors.initials: T
authors.lastname: Kubo
authors.forename: Taro
authors.initials: T
authors.lastname: Masunari
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Okada
authors.forename: Toru
authors.initials: T
authors.lastname: Kiguchi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sezaki
authors.forename: Shingo
authors.initials: S
authors.lastname: Harita
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Nakata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sonobe
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D000077143:Docetaxel; D004338:Drug Combinations; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D043823:Taxoids / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid