title: Lack of association of glutathione S-transferase M3 gene polymorphism with the susceptibility of lung cancer.
abstract: OBJECTIVE
  The conclusions of published reports on the relationship between the glutathione S-transferase M3 (GSTM3) A/B gene polymorphism and the risk of lung cancer are still debated. This meta-analysis was performed to evaluate the association between GSTM3 and the risk of lung cancer.
  
  
  METHODS
  Association investigations were identified from PubMed, Embase, and Cochrane Library, and eligible studies were included and synthesized using a meta-analysis method.
  
  
  RESULTS
  Eight reports were included into this meta-analysis for the association of GSTM3 A/B gene polymorphism and lung cancer susceptibility, covering 1,854 patients with lung cancer and 1,926 controls. No association between the GSTM3 A/B gene polymorphism and lung cancer was found in this meta-analysis (B allele: OR = 1.25, 95% CI: 0.89-1.76, P = 0.20; BB genotype: OR = 1.53, 95% CI: 0.71-3.32, P = 0.28; AA genotype: OR = 0.85, 95% CI: 0.59-1.23, P = 0.39).
  
  
  CONCLUSIONS
  The GSTM3 A/B gene polymorphism is not associated with lung cancer susceptibility. However, more studies on the relationship between GSTM3 A/B gene polymorphism and the risk of lung cancer should be performed in the future.
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, NanNing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Feng
authors.forename: Chun-Qiang
authors.initials: CQ
authors.lastname: Dong
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Shi
authors.forename: Hua-Fu
authors.initials: HF
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Bao-Shi
authors.initials: BS
authors.lastname: Zheng
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D016001:Confidence Intervals; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D018398:Homeodomain Proteins; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008175:Lung Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C473013:Hod protein, mouse; D018398:Homeodomain Proteins; D007527:Isoenzymes; D005982:Glutathione Transferase; C416969:glutathione transferase M3-3