title: A puzzling case of phospho-soda-induced hypocalcemia in a patient with multiple endocrine neoplasia type 1-associated primary hyperparathyroidism.
abstract: Although rare, symptomatic hypocalcemia may develop after the administration of phospho-soda. We herein present the case of a patient with phospho-soda-induced hypocalcemia who was surprisingly diagnosed with multiple endocrine neoplasia type 1 (MEN1) caused by a heterozygous mutation in the MEN1 gene (c628_631delACAG), thus resulting in a frameshift mutation (210ThrfsX224). In addition to being the first report of phospho-soda-induced hypocalcemia in a patient with MEN1-associated primary hyperparathyroidism, our report highlights the complex nature of calcium balance in the human body and helps clinicians to appreciate how confounding factors might affect the presentation of endocrine disorders.
authors.affiliation: Department of Internal Medicine, Tepecik Training and Research Hospital, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozveren
authors.forename: Baris
authors.initials: B
authors.lastname: Akinci
authors.forename: Ozer
authors.initials: O
authors.lastname: Makay
authors.forename: Banu
authors.initials: B
authors.lastname: Sarsik
authors.forename: Ilgin Yildirim
authors.initials: IY
authors.lastname: Simsir
authors.forename: Afig
authors.initials: A
authors.lastname: Berdeli
authors.forename: Mahir
authors.initials: M
authors.lastname: Akyildiz
mesh_terms: D000328:Adult; D001483:Base Sequence; D004252:DNA Mutational Analysis; D005260:Female; D016368:Frameshift Mutation; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications* / Q000473:pathology; D006996:Hypocalcemia / Q000139:chemically induced*; D054368:Laxatives / Q000009:adverse effects; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D010710:Phosphates / Q000009:adverse effects; D011518:Proto-Oncogene Proteins / Q000235:genetics
chemical_list: D054368:Laxatives; C105373:MEN1 protein, human; D010710:Phosphates; D011518:Proto-Oncogene Proteins; C018279:sodium phosphate