title: Tetracyclic triterpenoids and terpenylated coumarins from the bark of Ailanthus altissima ("Tree of Heaven").
abstract: Tetracyclic triterpenoids (named as altissimanins A-E, 1-5) and a terpenylated coumarin (denominated as altissimacoumarin G, 6), along with fifteen known compounds (7-21) were isolated from the bark of Ailanthus altissima. Structures of compounds 1-6 were established by spectroscopic methods and chemical transformations. Altissimanin A (1) is a tirucallane-type triterpenoid bearing an uncommon oxetane ring in the side-chain, while altissimanins D (4) and E (5) are two unprecedented dimers each consisting of one tirucallane-type and one dammarane-type triterpenoid moiety. All the isolates were evaluated for their cytotoxic effects against a small panel of human cancer cell lines.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
authors.forename: Zhi-Lai
authors.initials: ZL
authors.lastname: Hong
authors.forename: Juan
authors.initials: J
authors.lastname: Xiong
authors.forename: Shi-Biao
authors.initials: SB
authors.lastname: Wu
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhu
authors.forename: Jun-Lin
authors.initials: JL
authors.lastname: Hong
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Gang
authors.initials: G
authors.lastname: Xia
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
mesh_terms: D032268:Ailanthus / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D003374:Coumarins; D014315:Triterpenes