title: Effects of smoking cessation on hormonal levels in men.
abstract: Chronic smoking can cause imbalance in endocrine homeostasis and impairment of fertility in both sexes. The male reproductive system is more resilient, still the literature provides conflicting results about the influence of smoking on the steroid hormone levels. The data about smoking cessation are limited; there has not yet been a study primarily focused on changes in steroids levels. In our study, we analyzed levels of testosterone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), cortisol and sex hormone-binding globulin (SHBG) in male smokers and during smoking cessation. Monitored analytes were determined by RIA. The free testosterone index was calculated. Basal samples of men successful and unsuccessful in smoking cessation did not differ and monitored hormones could hardly predict success of smoking cessation. After one year without smoking, a significant BMI increase and SHBG decrease in former smokers was observed. The decrease in total testosterone was non-significant. Changes in SHBG and testosterone did not correlate with BMI, presumably due to the direct effect of smoking cessation.
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic.
authors.forename: H
authors.initials: H
authors.lastname: Hruškovičová
authors.forename: M
authors.initials: M
authors.lastname: Dušková
authors.forename: K
authors.initials: K
authors.lastname: Simůnková
authors.forename: M
authors.initials: M
authors.lastname: Hill
authors.forename: H
authors.initials: H
authors.lastname: Pospíšilová
authors.forename: B
authors.initials: B
authors.lastname: Rácz
authors.forename: E
authors.initials: E
authors.lastname: Králíková
authors.forename: K
authors.initials: K
authors.lastname: Vondra
authors.forename: L
authors.initials: L
authors.lastname: Stárka
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003687:Dehydroepiandrosterone / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage; D018722:Nicotinic Agonists / Q000008:administration & dosage; D011863:Radioimmunoassay; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D012907:Smoking / Q000097:blood; D016540:Smoking Cessation / Q000379:methods; D000074606:Smoking Prevention; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D061485:Tobacco Use Cessation Devices; D057968:Transdermal Patch; D015430:Weight Gain
chemical_list: D015415:Biomarkers; D006728:Hormones; D018722:Nicotinic Agonists; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D009538:Nicotine; D006854:Hydrocortisone