title: Light-addressable capsules as caged compound matrix for controlled triggering of cytosolic reactions.
abstract: Release me: polyelectrolyte capsules with different cargo in their cavities and plasmonic and magnetic nanoparticles in their walls were synthesized. Enzymatic reactions were triggered inside cells by light-mediated opening of two individual capsules containing either an enzyme or its substrate, by using photothermal heating. Furthermore, this technique allows controlled release of mRNA from capsules, thereby resulting in synthesis of green fluorescent protein (GFP).
authors.affiliation: Fachbereich Physik and WZWM, Philipps Universität Marburg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Ochs
authors.forename: Susana
authors.initials: S
authors.lastname: Carregal-Romero
authors.forename: Joanna
authors.initials: J
authors.lastname: Rejman
authors.forename: Kevin
authors.initials: K
authors.lastname: Braeckmans
authors.forename: Stefaan C
authors.initials: SC
authors.lastname: De Smedt
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Parak
mesh_terms: D002214:Capsules / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003600:Cytosol / Q000737:chemistry / Q000378:metabolism; D015870:Gene Expression; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D002214:Capsules