title: [Transcriptional control of ciliogenesis in animal development].
abstract: Cilia and flagella are eukaryotic organelles with a conserved structure and function           from unicellular organisms to human. In animals, different types of cilia can be found and           cilia assembly during development is a highly dynamic process. Ciliary defects in human           lead to a wide spectrum of diseases called ciliopathies. Understanding the molecular           mechanisms that govern dynamic cilia assembly during development and in different tissues           in metazoans is an important biological challenge. The FOXJ1 (Forkhead Box J1) and RFX           (Regulatory Factor X) family of transcription factors have been shown to be important           factors in ciliogenesis control. FOXJ1 proteins are required for motile ciliogenesis in           vertebrates. By contrast, RFX proteins are essential to assemble both primary and motile           cilia through the regulation of specific sets of genes such as those encoding           intraflagellar transport components. Recently, new actors with more specific roles in           cilia biogenesis and physiology have also been discovered. All these factors are subject           to complex regulation, allowing for the dynamic and specific regulation of ciliogenesis in           metazoans.
authors.affiliation: Centre de Genetique et de Physiologie Moleculare et Cellulaire, Universite Lyon, Villeurbanne, Lyon, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Jerber
authors.forename: Joëlle
authors.initials: J
authors.lastname: Thomas
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Durand
mesh_terms: D000818:Animals; D002923:Cilia / Q000235:genetics* / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009024:Morphogenesis; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors