title: Evaluation of the hepatoprotective Effects of Lantadene A, a pentacyclic triterpenoid of Lantana plants against acetaminophen-induced liver damage.
abstract: The aim of the present study was to evaluate the hepatoprotective activity of lantadene A against acetaminophen-induced liver toxicity in mice was studied. Activity was measured by monitoring the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin, along with histo-pathological analysis. Silymarin was used as positive control. A bimodal pattern of behavioural toxicity was exhibited by the lantadene A-treated group at the beginning of the treatment. However, treatment with lantadene A and silymarin resulted in an increase in the liver weight compared with the acetaminophen treated group. The results of the acetaminophen-induced liver toxicity experiments showed that mice treated with lantadene A (500 mg/kg) showed a significant decrease in the activity of ALT, AST and ALP and the level of bilirubin, which were all elevated in the acetaminophen treated group (p < 0.05). Histological studies supported the biochemical findings and a maximum improvement in the histoarchitecture was seen. The lantadene A-treated group showed remarkable protective effects against histopathological alterations, with comparable results to the silymarin treated group. The current study confirmed the hepatoprotective effects of lantadene A against the model hepatotoxicant acetaminophen, which is likely related to its potent antioxidative activity.
authors.affiliation: Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia. gracelynn87@gmail.com
authors.forename: Chong
authors.initials: C
authors.lastname: Grace-Lynn
authors.forename: Yeng
authors.initials: Y
authors.lastname: Chen
authors.forename: Lachimanan Yoga
authors.initials: LY
authors.lastname: Latha
authors.forename: Jagat R
authors.initials: JR
authors.lastname: Kanwar
authors.forename: Subramanion L
authors.initials: SL
authors.lastname: Jothy
authors.forename: Soundararajan
authors.initials: S
authors.lastname: Vijayarathna
authors.forename: Sreenivasan
authors.initials: S
authors.lastname: Sasidharan
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects; D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D032410:Lantana / Q000737:chemistry; D008099:Liver / Q000187:drug effects / Q000473:pathology; D051379:Mice; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents / Q000008:administration & dosage; D012838:Silymarin / Q000008:administration & dosage
chemical_list: D020011:Protective Agents; D012838:Silymarin; D000082:Acetaminophen; D009828:Oleanolic Acid; C019074:rehmannic acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin