title: Developing dementia prevention trials: baseline report of the Home-Based Assessment study.
abstract: This report describes the baseline experience of the multicenter, Home-Based Assessment study, designed to develop methods for dementia prevention trials using novel technologies for test administration and data collection. Nondemented individuals of 75 years of age or more were recruited and evaluated in-person using established clinical trial outcomes of cognition and function, and randomized to one of 3 assessment methodologies: (1) mail-in questionnaire/live telephone interviews [mail-in/phone (MIP)]; (2) automated telephone with interactive voice recognition; and (3) internet-based computer Kiosk. Brief versions of cognitive and noncognitive outcomes were adapted to each methodology and administered at baseline and repeatedly over a 4-year period. "Efficiency" measures assessed the time from screening to baseline, and staff time required for each methodology. A total of 713 individuals signed consent and were screened; 640 met eligibility and were randomized to one of 3 assessment arms; and 581 completed baseline. Dropout, time from screening to baseline, and total staff time were highest among those assigned to internet-based computer Kiosk. However, efficiency measures were driven by nonrecurring start-up activities suggesting that differences may be mitigated over a long trial. Performance among Home-Based Assessment instruments collected through different technologies will be compared with established outcomes over this 4-year study.
authors.affiliation: *Mount Sinai School of Medicine §New York University Langone Medical Center, New York †James J Peters VA Medical Center, Bronx, NY ‡University of California (UCSD), San Diego, La Jolla, CA ∥Oregon Health & Science University ¶Portland VAMC, Portland, OR #Center for Psychological Consultation, Madison, WI **University of Arkansas for Medical Sciences, Little Rock, AR.
authors.forename: Mary
authors.initials: M
authors.lastname: Sano
authors.forename: Susan
authors.initials: S
authors.lastname: Egelko
authors.forename: Michael
authors.initials: M
authors.lastname: Donohue
authors.forename: Steven
authors.initials: S
authors.lastname: Ferris
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kaye
authors.forename: Tamara L
authors.initials: TL
authors.lastname: Hayes
authors.forename: James C
authors.initials: JC
authors.lastname: Mundt
authors.forename: Chung-Kai
authors.initials: CK
authors.lastname: Sun
authors.forename: Silvia
authors.initials: S
authors.lastname: Paparello
authors.forename: Paul S
authors.initials: PS
authors.lastname: Aisen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003704:Dementia / Q000175:diagnosis / Q000517:prevention & control* / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D015577:Geriatric Assessment / Q000379:methods*; D006792:House Calls; D006801:Humans; D020407:Internet / Q000592:standards; D008137:Longitudinal Studies; D008297:Male; D058028:Research Report / Q000592:standards; D011795:Surveys and Questionnaires / Q000592:standards; D013689:Telephone / Q000592:standards