title: Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis.
abstract: We investigate the expression and localization of the tumor suppressor protein pVHL as well as the oncoprotein Aurora A kinase in kidney cancer. Both Aurora A kinase and pVHL protein status were evaluated using immunohistochemistry. The Aurora A expression is correlated with the Fuhrman grade and the TNM stage, while the pVHL expression is correlated with the capsule rupture and the TNM stage. Aurora A kinase expression increases in malignant tissue comparing to the non-malignant one. And there is a decrease in pVHL expression from the adjacent healthy tissues to the tumor`s ones. The two kinds of opposite tumor profiles display significant distribution difference according to TNM stages. It could be proposed that the absence of Aurora A protein associated with a strong expression of pVHL in clear cells kidney carcinoma are of good prognosis for the disease.
authors.affiliation: Department of Biology, Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, Tunisia. science.biologique@yahoo.fr
authors.forename: Imen
authors.initials: I
authors.lastname: Ferchichi
authors.forename: Nadia
authors.initials: N
authors.lastname: Kourda
authors.forename: Samia
authors.initials: S
authors.lastname: Sassi
authors.forename: Khaled Ben
authors.initials: KB
authors.lastname: Romdhane
authors.forename: Sarra
authors.initials: S
authors.lastname: Balatgi
authors.forename: Jean Yves
authors.initials: JY
authors.lastname: Cremet
authors.forename: Claude
authors.initials: C
authors.lastname: Prigent
authors.forename: Amel Benammar
authors.initials: AB
authors.lastname: Elgaaied
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D064127:Aurora Kinases; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015854:Up-Regulation; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000378:metabolism*
chemical_list: D051794:Von Hippel-Lindau Tumor Suppressor Protein; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; C497446:VHL protein, human