title: Synergistically enhance magnetic resonance/fluorescence imaging performance of responsive polymeric nanoparticles under mildly acidic biological milieu.
abstract: Core cross-linked (CCL) polymeric micelles covalently labeled with DOTA(Gd) and green- emitting NBD fluorophores within pH-responsive cores are fabricated, which can serve as a dual-modality MR/fluorescence imaging system and exhibit mildly acidic pH-triggered turn-on or enhancement of signal intensities for both imaging modalities. Compared to non-crosslinked diblock precursor, CCL micelles demonstrate better MR and fluorescence imaging performance due to structural stability and integrity endowed by the core cross-linking procedure. Furthermore, selective enhancement of MR/fluorescence imaging signal intensities of the dual-modality imaging system can also be actuated under specific intracellular microenvironments such as mildly acidic organelles.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Hu
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Guoying
authors.initials: G
authors.lastname: Zhang
authors.forename: Fan
authors.initials: F
authors.lastname: Jin
authors.forename: Shiyong
authors.initials: S
authors.lastname: Liu
mesh_terms: D005453:Fluorescence; D056945:Hep G2 Cells; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation* / Q000379:methods; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D061848:Optical Imaging; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D006573:Heterocyclic Compounds, 1-Ring; D008823:Micelles; D011108:Polymers; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D011092:Polyethylene Glycols