title: Complement in antineutrophil cytoplasmic antibody-associated vasculitis.
abstract: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a group of autoimmune disorders. It was previously assumed that the complement system is not involved in the development of ANCA-associated vasculitis due to its "pauci-immune" feature in renal histology. However, increasing evidence indicates that activation of the complement system, especially via the alternative complement pathway, plays a crucial role in the pathogenesis of ANCA-associated vasculitis. In this brief review, we discuss the evidence, including in vivo, in vitro, and clinical studies, for complement system activation in ANCA-associated vasculitis.
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, 100034, Beijing, China.|Institute of Nephrology, Peking University, 100034, Beijing, China.|Key Laboratory of Renal Disease, Ministry of Health of China, 100034, Beijing, China.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, 100034, Beijing, China.|Peking-Tsinghua Center for Life Sciences, 100034, Beijing, China.|Hubei University of Traditional Chinese Medicine, Wuchang, 430061, Wuhan, China.|Hubei Hospital of Traditional Chinese Medicine, Wuchang, 430061, Wuhan, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, 100034, Beijing, China. chenmin74@sina.com.|Institute of Nephrology, Peking University, 100034, Beijing, China. chenmin74@sina.com.|Key Laboratory of Renal Disease, Ministry of Health of China, 100034, Beijing, China. chenmin74@sina.com.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, 100034, Beijing, China. chenmin74@sina.com.|Peking-Tsinghua Center for Life Sciences, 100034, Beijing, China. chenmin74@sina.com.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, 100034, Beijing, China.|Institute of Nephrology, Peking University, 100034, Beijing, China.|Key Laboratory of Renal Disease, Ministry of Health of China, 100034, Beijing, China.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, 100034, Beijing, China.|Peking-Tsinghua Center for Life Sciences, 100034, Beijing, China.
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Zhao
mesh_terms: D000818:Animals; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000097:blood / Q000276:immunology*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D003167:Complement Activation; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D003165:Complement System Proteins