title: Analgesic and anti-inflammatory properties of methanol extract of Cnestis ferruginea in rodents.
abstract: OBJECTIVE
  To evaluate the analgesic and antiinflammatory activities of the methanol extract of Cnestis ferruginea (CF) in rodents.
  
  
  METHODS
  The antinociceptive activity of CF was evaluated using thermal (hot plate and tail flick tests) and chemical (acetic acid induced writhing and formalin tests) methods. The anti-inflammatory effects were studied using the cotton pellet granuloma and carrageenan induced paw edema tests.
  
  
  RESULTS
  The extract (300-500 mg/kg, per oral), dissolved in normal saline produced a dose dependent analgesic effect on a hot plate maintained at 55 +/- 2 degrees C as well as on the early and late phases of formalin induced paw licking in rats. At the same doses, the plant extract also significantly (p < 0.05) inhibited the carrageenan induced paw edema and cotton pellet granuloma formation in rats.
  
  
  CONCLUSIONS
  The results suggest that the methanol extract of CF possesses analgesic and antiinflammatory activities.
authors.affiliation: Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria. gibironk@yahoo.com
authors.forename: G F
authors.initials: GF
authors.lastname: Ibironke
authors.forename: G A
authors.initials: GA
authors.lastname: Odewole
mesh_terms: D000700:Analgesics / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis / Q000627:therapeutic use*; D002351:Carrageenan; D031961:Connaraceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051379:Mice; D009549:Nigeria; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan