title: Systems biology of pathogen-host interaction: networks of protein-protein interaction within pathogens and pathogen-human interactions in the post-genomic era.
abstract: Infectious diseases comprise some of the leading causes of death and disability worldwide. Interactions between pathogen and host proteins underlie the process of infection. Improved understanding of pathogen-host molecular interactions will increase our knowledge of the mechanisms involved in infection, and allow novel therapeutic solutions to be devised. Complete genome sequences for a number of pathogenic microorganisms, as well as the human host, has led to the revelation of their protein-protein interaction (PPI) networks. In this post-genomic era, pathogen-host interactions (PHIs) operating during infection can also be mapped. Detailed systematic analyses of PPI and PHI data together are required for a complete understanding of pathogenesis of infections. Here we review the striking results recently obtained during the construction and investigation of these networks. Emphasis is placed on studies producing large-scale interaction data by high-throughput experimental techniques.
authors.affiliation: Department of Chemical Engineering, Boǧaziçi University, Istanbul, Turkey.
authors.forename: Saliha D
authors.initials: SD
authors.lastname: Durmuş Tekir
authors.forename: Kutlu Ö
authors.initials: KÖ
authors.lastname: Ülgen
mesh_terms: D003141:Communicable Diseases / Q000378:metabolism*; D030562:Databases, Protein; D054884:Host-Pathogen Interactions; D006801:Humans; D060066:Protein Interaction Maps; D049490:Systems Biology / Q000379:methods*