title: Organocatalytic conjugate addition promoted by multi-hydrogen-bond cooperation: access to chiral 2-amino-3-nitrile-chromenes.
abstract: A new efficient enantioselective conjugate addition strategy has been disclosed to rapidly construct 2-amino-3-nitrile-chromene complexes via a multi-hydrogen-bond cooperative activation model.
authors.affiliation: Department of Chemistry, National University of Singapore, Block S15, Level 5, 3 Science Drive 3, Singapore 11754, Singapore.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Li
authors.forename: Jiayao
authors.initials: J
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000588:Amines / Q000737:chemistry*; D001580:Benzopyrenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: C584686:2-amino-3-nitrile-chromene; D000588:Amines; D001580:Benzopyrenes; D009570:Nitriles; D013890:Thiourea