title: Validation of the Innsbruck REM sleep behavior disorder inventory.
abstract: A diagnosis of definite REM sleep behavior disorder requires both a positive history for REM sleep behavior disorder and polysomnographic demonstration of REM sleep without atonia. To improve and facilitate screening for REM sleep behavior disorder, there is a need for simple clinical tools with sufficient sensitivity and specificity for the identification of subjects with probable REM sleep behavior disorder. We developed a short REM sleep behavior disorder screening questionnaire with 7 REM sleep behavior disorder- and 2 non-REM sleep behavior disorder-specific control items and performed a validation study in 70 REM sleep behavior disorder subjects and 140 sleep disorder controls. Response patterns to all 7 REM sleep behavior disorder-specific items differed between REM sleep behavior disorder and non-REM sleep behavior disorder patients (all P < 0.05), whereas the 2 non-REM sleep behavior disorder-specific control items did not differentiate between REM sleep behavior disorder and non-REM sleep behavior disorder (all P > .05). In 5 of the 7 REM sleep behavior disorder-specific items, AUC was greater than 0.700. These 5 items were included in the Innsbruck REM sleep behavior disorder inventory. In this questionnaire, a cutoff of 0.25 (number of positive symptoms divided by number of answered questions) had a sensitivity of 0.914 and a specificity of 0.857 for both idiopathic and Parkinson's-related REM sleep behavior disorder (AUC, 0.886). The Innsbruck REM sleep behavior disorder inventory is a promising, easy-to-use, short screening tool for REM sleep behavior disorder with excellent sensitivity and specificity for both idiopathic and Parkinson's-related REM sleep behavior disorder.
authors.affiliation: Department of Neurology, Innsbruck Medical University, Innsbruck, Austria. birgit.frauscher@i-med.ac.at
authors.forename: Birgit
authors.initials: B
authors.lastname: Frauscher
authors.forename: Laura
authors.initials: L
authors.lastname: Ehrmann
authors.forename: Laura
authors.initials: L
authors.lastname: Zamarian
authors.forename: Florentine
authors.initials: F
authors.lastname: Auer
authors.forename: Thomas
authors.initials: T
authors.lastname: Mitterling
authors.forename: David
authors.initials: D
authors.lastname: Gabelia
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Brandauer
authors.forename: Margarete
authors.initials: M
authors.lastname: Delazer
authors.forename: Werner
authors.initials: W
authors.lastname: Poewe
authors.forename: Birgit
authors.initials: B
authors.lastname: Högl
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis*; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D055815:Young Adult