title: [Advancement of research on polyamidoamine dendrimers].
abstract: Polyamidoamine (PAMAM) dendrimers is synthesized by the American scientist, Tomalia, in 1985 and is now used widely in many fields such as gene carriers, photoelectric sensor, wastewater treatment, drug carriers and catalyst. The present paper mainly reviews the structure and methods of synthesis, celluar cytotoxicity, achievements of gene and drug carriers research, advancement and prospect of PAMAM as a carrier in glioma therapy. Besides, it also involves an outline for the future research of the radiotherapy for glioma.
authors.affiliation: Department of Radiation Therapy, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Longzhen
authors.initials: L
authors.lastname: Zhang
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry*; D004337:Drug Carriers; D005822:Genetic Vectors
chemical_list: D001672:Biocompatible Materials; D050091:Dendrimers; D004337:Drug Carriers; C104700:PAMAM Starburst