title: Aminocarbonylations employing Mo(CO)6 and a bridged two-vial system: allowing the use of nitro group substituted aryl iodides and aryl bromides.
abstract: A bridged two-vial system aminocarbonylation protocol where Mo(CO)(6) functions as an external in situ solid source of CO has been developed. For the first time both nitro group containing aryl/heteroaryl iodides and bromides gave good to excellent yields in the Mo(CO)(6)-mediated and palladium(0)-catalyzed conversion to benzamides, while the identical one-vessel protocol afforded extensive reduction of the nitro functionality. The above-mentioned bridged two-compartment protocol furnished good results with both primary amines and secondary amines and sluggish aniline nucleophiles at 65-85 °C reaction temperatures.
authors.affiliation: Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala Biomedical Center, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden.
authors.forename: Patrik
authors.initials: P
authors.lastname: Nordeman
authors.forename: Luke R
authors.initials: LR
authors.lastname: Odell
authors.forename: Mats
authors.initials: M
authors.lastname: Larhed
mesh_terms: D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D054879:Halogenation; D007659:Ketones / Q000737:chemistry*; D008982:Molybdenum / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
chemical_list: D007659:Ketones; D009574:Nitro Compounds; C434645:hexacarbonylmolybdenum; D010165:Palladium; D008982:Molybdenum; D001554:Benzene