title: Affective disorder and hyperandrogenism.
abstract: A 40-year-old female patient with bipolar disorder and premenstrual dysphoric disorder did not present any physical evidence of virilization, treated with quetiapine and lithium carbonate. Laboratory testing showed evidence of hyperandrogenism (Testosterone levels 88.5ng/dL). After control, testosterone levels were normal (free testosterone 0.20 pg/ml, total testosterone 27.90ng/dl), as free thyroxine levels decreased (T4 0.83ng/dl) and increased progesterone levels (progesterone 3.80ng/ml). We consider an association between increased androgenic hormone levels in women, quetiapine and lithium carbonate treatment as well as the presence of an affective disorder and premenstrual dysphoric disorder. Some relevant patents are also outlined in this review.
authors.affiliation: Universidad de Carabobo, Facultad de Ciencias de la Salud, Departamento de Ciencias Fisiológicas, Valencia, Venezuela.
authors.forename: Celen
authors.initials: C
authors.lastname: Zerouni
authors.forename: Elaine
authors.initials: E
authors.lastname: Kummerow
authors.forename: Mariflor
authors.initials: M
authors.lastname: Martinez
authors.forename: Ana
authors.initials: A
authors.lastname: Diaz
authors.forename: Uribe
authors.initials: U
authors.lastname: Ezequiel
authors.forename: Richard
authors.initials: R
authors.lastname: Wix-Ramos
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy*; D003987:Dibenzothiazepines / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000175:diagnosis*; D016651:Lithium Carbonate / Q000627:therapeutic use; D010330:Patents as Topic; D011293:Premenstrual Syndrome / Q000378:metabolism*; D000069348:Quetiapine Fumarate; D013739:Testosterone / Q000097:blood
chemical_list: D018692:Antimanic Agents; D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D016651:Lithium Carbonate; D000069348:Quetiapine Fumarate; D013739:Testosterone