title: Poly(2-oxazoline)-derived contact biocides: contributions to the understanding of antimicrobial activity.
abstract: A set of poly(2-oxazoline)-derived (co-)polymers was prepared by microwave-assisted polymerizations and acid-mediated hydrolysis and tested for antimicrobial activity in 50 × 50 × 2 mm PP compound plates containing 5 wt% of the polymers. Antimicrobial activity against gram-negative E. coli and P. aeruginosa as well as C. albicans depended only on the degree of hydrolysis, while antimicrobial activity against gram-positive S. aureus was only observed for hydrolyzed poly(2-nonyl-2-oxazoline)s. The surface energies of the compound plates compared to pure PP were hardly altered, and the compounds can be considered as alternatives for PP. The presence of the biocide additives at the surface of the PP compound plates could be shown by combined ATR-IR, zeta potential, and SEM-EDX measurements. Antimicrobial activity was maintained during double incubation as well as for lowered amounts of the biocide additive of 1% in PP compound plates.
authors.affiliation: Polymer Competence Center Leoben GmbH, Roseggerstrasse 12, 8700 Leoben, Austria.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Kelly
authors.forename: Verena
authors.initials: V
authors.lastname: Kaltenhauser
authors.forename: Inge
authors.initials: I
authors.lastname: Mühlbacher
authors.forename: Karl
authors.initials: K
authors.lastname: Rametsteiner
authors.forename: Harald
authors.initials: H
authors.lastname: Kren
authors.forename: Christian
authors.initials: C
authors.lastname: Slugovc
authors.forename: Franz
authors.initials: F
authors.lastname: Stelzer
authors.forename: Frank
authors.initials: F
authors.lastname: Wiesbrock
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects; D004202:Disinfectants / Q000138:chemical synthesis* / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D004202:Disinfectants; D010080:Oxazoles; D011108:Polymers; C577913:poly(2-oxazoline)