title: Treatment with interferon-β does not induce anti-nuclear and anti-neuronal serum autoantibodies in multiple sclerosis patients.
abstract: Type I interferons (IFNs) are known to enhance humoral immunity. Here, we investigated the prevalence and titer of anti-nuclear and anti-neuronal IgG autoantibodies in 71 relapsing-remitting MS patients classified based on their clinical response to IFNβ in paired sera obtained at baseline and after 12months of treatment. All samples were negative for antibodies against cytoplasmic rods/rings, synaptic proteins and paraneoplastic antibodies. Regarding anti-nuclear, anti-filament and anti-myelin antibodies, pre- and post-treatment prevalence and titers did not differ significantly between IFNβ responders and non-responders. Thus, pattern of anti-nuclear and anti-neuronal autoantibodies does not predict the response to IFNβ in MS patients.
authors.affiliation: Servei de Neurologia/Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain. manuel.comabella@vhir.org
authors.forename: M
authors.initials: M
authors.lastname: Comabella
authors.forename: K
authors.initials: K
authors.lastname: Rentzsch
authors.forename: J
authors.initials: J
authors.lastname: Río
authors.forename: M F
authors.initials: MF
authors.lastname: Bustamante
authors.forename: K
authors.initials: K
authors.lastname: Borowski
authors.forename: W
authors.initials: W
authors.lastname: Stoecker
authors.forename: X
authors.initials: X
authors.lastname: Montalban
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000096:biosynthesis* / Q000097:blood; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology*; D009474:Neurons / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D016899:Interferon-beta