title: Natural α-amino acids applied in the synthesis of imidazo[1,5-a]N-heterocycles under mild conditions.
abstract: A facile iodine-mediated decarboxylative cyclization from α-amino acids and N-heterocyclic carbaldehydes was developed. By virtue of this method, a series of imidazo[1,5-a]N-heterocycles can be synthesized efficiently under mild conditions. A tentative reaction mechanism was proposed based on the experimental results and previous reports.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhang
authors.forename: Fengfeng
authors.initials: F
authors.lastname: Guo
authors.forename: Baiqun
authors.initials: B
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D001688:Biological Products; D007093:Imidazoles