title: Antiinflammatory activity of flavonoids.
abstract: Fourteen flavonoids (flavones,- flavanones and chalcones) were assayed for oral antiinflammatory activity using carrageenan-induced hind paw edema in rats. The structural features necessary for antiinflammatory activity appear to be the presence of methoxyl groups at C5 and C7 of ring A and the pyrano ring B of the flavonoid molecule. Negligible or low antiinflammatory activities were found in the chalcone derivatives. The difference in the efficacy of the flavonoids tested possibly depends on their pharmacokinetic properties.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50002, Thailand.
authors.forename: A
authors.initials: A
authors.lastname: Panthong
authors.forename: D
authors.initials: D
authors.lastname: Kanjanapothi
authors.forename: P
authors.initials: P
authors.lastname: Tuntiwachwuttikul
authors.forename: O
authors.initials: O
authors.lastname: Pancharoen
authors.forename: V
authors.initials: V
authors.lastname: Reutrakul