title: Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent.
abstract: Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. PPRs were prepared by addition of α-cyclodextrin rings to functionalized polyethylene glycol (PEG) chain with hydrophobic triazine end-groups. Non-covalent interactions between SPIONs and PPRs led to the assembly of SPIONs@PRs hybrid nanomaterials. Measurements of the (1)H Nuclear Magnetic Resonance (NMR) relaxation times T(1) and T(2) allowed us to determine the NMR dispersion profiles. Comparison between our SPIONs@PRs hybrid nano-compound and the commercial SPION compound, Endorem, showed a higher transverse relaxivity for SPIONs@PRs. In vitro MRI experiments showed that our SPIONs@PRs produces better negative contrast compared to Endorem and can be considered as a novel MRI contrast agent.
authors.affiliation: Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran.
authors.forename: Forouzan
authors.initials: F
authors.lastname: Hosseini
authors.forename: Arash
authors.initials: A
authors.lastname: Panahifar
authors.forename: Mohsen
authors.initials: M
authors.lastname: Adeli
authors.forename: Houshang
authors.initials: H
authors.lastname: Amiri
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lascialfari
authors.forename: Francesco
authors.initials: F
authors.lastname: Orsini
authors.forename: Michael R
authors.initials: MR
authors.lastname: Doschak
authors.forename: Morteza
authors.initials: M
authors.lastname: Mahmoudi
mesh_terms: D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis*; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry; D003911:Dextrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000648:ultrastructure; D057927:Hydrophobic and Hydrophilic Interactions; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D018625:Microscopy, Atomic Force; D049329:Nanostructures / Q000648:ultrastructure; D020442:Poloxamer / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D043862:Rotaxanes / Q000138:chemical synthesis* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D020099:Coated Materials, Biocompatible; D003287:Contrast Media; D003505:Cyclodextrins; D003911:Dextrans; D058185:Magnetite Nanoparticles; D043862:Rotaxanes; C475673:polyrotaxane; D020442:Poloxamer; D011092:Polyethylene Glycols; C065507:ferumoxides