title: Acetophenones - compounds from plant origin with inhibitory effects on neutrophil in vitro respiration burst activity.
abstract: Acetophenone derivatives either newly synthetized or purchased from commercial sources have been tested for their effects on superoxide anion (O(2)(-)) production of human polymorphonuclear neutrophils (PMN) stimulated with N-formylmethionylleucylphenylalanine (FMLP). Apocynin and 4-hydroxyethyloxy-3-methoxy-acetophenone exerted the most pronounced inhibition. Agly-cones were generally more active than the corresponding glucosides. Hydroxyl or hydroxy ethyl groups at position C-4 and methoxy or methyl groups at position C-3 were found to be essential for a marked activity of the acetophenone derivatives. Testing of different concentrations of these compounds showed that the inhibition of superoxide anion (O(2)(-)) production is concentration-dependent.
authors.affiliation: Institute of Pharmacognosy, University of Innsbruck, Innsbruck, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Stuppner
authors.forename: O
authors.initials: O
authors.lastname: Reinisch
authors.forename: C J
authors.initials: CJ
authors.lastname: Wiedermann
authors.forename: H
authors.initials: H
authors.lastname: Wagner