title: Lyophilized wafers comprising carrageenan and pluronic acid for buccal drug delivery using model soluble and insoluble drugs.
abstract: Lyophilized muco-adhesive wafers with optimum drug loading for potential buccal delivery have been developed. A freeze-annealing cycle was used to obtain optimized wafers from aqueous gels containing 2% κ-carrageenan (CAR 911), 4% pluronic acid (F127), 4.4% (w/w) polyethylene glycol with 1.8% (w/w) paracetamol or 0.8% (w/w) ibuprofen. Thermogravimetric analysis showed acceptable water content between 0.9 and 1.5%. Differential scanning calorimetry and X-ray diffraction showed amorphous conversion for both drugs. Texture analysis showed ideal mechanical and mucoadhesion characteristics whilst both drugs remained stable over 6 months and drug dissolution at a salivary pH showed gradual release within 2h. The results show the potential of CAR 911 and F127 based wafers for buccal mucosa drug delivery.
authors.affiliation: Department of Pharmaceutical, Chemical & Environmental Sciences, School of Science, University of Greenwich, Medway Campus, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.
authors.forename: Farnoosh
authors.initials: F
authors.lastname: Kianfar
authors.forename: Milan
authors.initials: M
authors.lastname: Antonijevic
authors.forename: Babur
authors.initials: B
authors.lastname: Chowdhry
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Boateng
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage* / Q000737:chemistry; D000268:Adhesiveness; D000278:Administration, Buccal; D002152:Calorimetry, Differential Scanning; D002351:Carrageenan / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D004355:Drug Stability; D005612:Freeze Drying; D005782:Gels; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D020442:Poloxamer / Q000737:chemistry*; D012995:Solubility; D013818:Thermogravimetry; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D005782:Gels; D004364:Pharmaceutical Preparations; D014867:Water; D020442:Poloxamer; D000082:Acetaminophen; D002351:Carrageenan; D007052:Ibuprofen