title: Enhanced neuroprotection by local intra-arterial infusion of human albumin solution and local hypothermia.
abstract: OBJECTIVE
  We investigated the potential benefit of using a local infusion of low-dose and cold human albumin in ischemic rats as compared with systemic delivery.
  
  
  METHODS
  Stroke was induced in rats, and at 2 hours treatment groups received 0°C saline or low-dose albumin at 0°C or 37°C infused into the ischemic area.
  
  
  RESULTS
  The local low-dose cold albumin infusion, which achieved the hypothermic temperature (P<0.001), produced the greatest reduction in infarct volume and the best recovery of neurological function.
  
  
  CONCLUSIONS
  The local low-dose cold albumin infusion into the ischemic area offered a combination of regional brain hypothermia and albumin administration, which enhanced neuroprotection and would be beneficial in the clinical setting.
authors.affiliation: Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Vance
authors.initials: V
authors.lastname: Fredrickson
authors.forename: Yuchuan
authors.initials: Y
authors.lastname: Ding
authors.forename: Huakun
authors.initials: H
authors.lastname: Cheng
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Ling
authors.forename: Xunming
authors.initials: X
authors.lastname: Ji
mesh_terms: D000818:Animals; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy; D007261:Infusions, Intra-Arterial; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D019999:Pharmaceutical Solutions / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000008:administration & dosage*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
chemical_list: D018696:Neuroprotective Agents; D019999:Pharmaceutical Solutions; D012709:Serum Albumin