title: Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand.
abstract: Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation). Based on a case-control in Thailand, we have measured R249S and the status of HBX gene in plasma DNA of 176 cases and 133 referents. Detection of HBX complete sequences was associated with R249S in HCC with no documented prior cirrhosis but not in HCC developing in a context of cirrhosis or in non-cancer chronic liver diseases. Thus, R249S may specifically cooperate with HBX in a pathway to HCC that bypasses cirrhosis.
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Ortiz-Cuaran
authors.forename: Stephanie
authors.initials: S
authors.lastname: Villar
authors.forename: Doriane
authors.initials: D
authors.lastname: Gouas
authors.forename: Gilles
authors.initials: G
authors.lastname: Ferro
authors.forename: Amelie
authors.initials: A
authors.lastname: Plymoth
authors.forename: Thiravud
authors.initials: T
authors.lastname: Khuhaprema
authors.forename: Anant
authors.initials: A
authors.lastname: Kalalak
authors.forename: Suleeporn
authors.initials: S
authors.lastname: Sangrajrang
authors.forename: Marlin D
authors.initials: MD
authors.lastname: Friesen
authors.forename: John D
authors.initials: JD
authors.lastname: Groopman
authors.forename: Pierre
authors.initials: P
authors.lastname: Hainaut
mesh_terms: D000328:Adult; D000348:Aflatoxins / Q000009:adverse effects*; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000209:etiology* / Q000473:pathology; D016022:Case-Control Studies; D004247:DNA / Q000032:analysis / Q000235:genetics; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000150:complications* / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications* / Q000473:pathology; D008113:Liver Neoplasms / Q000097:blood / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D011042:Poisons / Q000009:adverse effects; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D015534:Trans-Activators / Q000097:blood*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D054334:Viral Regulatory and Accessory Proteins
chemical_list: D000348:Aflatoxins; D015415:Biomarkers; D011042:Poisons; C495901:TP53 protein, human; D015534:Trans-Activators; D016159:Tumor Suppressor Protein p53; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein; D004247:DNA