title: Densanins A and B, new macrocyclic pyrrole alkaloids isolated from the marine sponge Haliclona densaspicula.
abstract: Densanins A (1) and B (2) were isolated from the sponge Haliclona densaspicula. On the basis of spectral data and the Mosher ester method, the complete structures were characterized as hexacyclic diamine alkaloids, which were probably derived from 3-alkylpyridine. Compounds 1 and 2 showed relatively potent inhibitory effects on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells with IC(50) values of 1.05 and 2.14 μM, respectively.
authors.affiliation: Department of Oceanography, Kunsan National University, Jeonbuk 573-701, South Korea.
authors.forename: Buyng Su
authors.initials: BS
authors.lastname: Hwang
authors.forename: Jung Soon
authors.initials: JS
authors.lastname: Oh
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Jeong
authors.forename: Chung J
authors.initials: CJ
authors.lastname: Sim
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Rho
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D003959:Diamines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047129:Haliclona / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008386:Marine Biology; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D056910:Republic of Korea
chemical_list: D000470:Alkaloids; D003959:Diamines; D008070:Lipopolysaccharides; D011758:Pyrroles; C578819:densanin A; C578820:densanin B; D009569:Nitric Oxide