title: Breast cancer manifested by hematologic disorders.
abstract: Breast cancer is the most common type of cancer in women. However, it is very rarely manifested as hematologic disorders. A 35-year-old woman was admitted because of disseminated intravascular coagulation. Examinations revealed the presence of breast cancer in her left breast; therefore, paclitaxel was administered weekly. Although disseminated intravascular coagulation was controlled, pulmonary dysfunction due to lymphangitis carcinomatosa suddenly occurred 10 weeks after treatment. Pulmonary dysfunction was effectively treated with epirubicin and cyclophosphamide. Twenty-three weeks after treatment, the patient developed liver dysfunction accompanied with jaundice due to progressive metastatic lesions in the liver; liver dysfunction improved after the administration of vinorelbine. Subsequently, because of the recurrence of pulmonary dysfunction, rechallenge with epirubicin and cyclophosphamide was performed and was effective; however, this therapy was discontinued because of its adverse effects. She expired of liver failure 33 weeks after the occurrence of disseminated intravascular coagulation. Metastatic tumors in the bone marrow, lung, and liver showed different sensitivities to different anti-cancer agents. We report a case of breast cancer manifested by hematologic disorders which was treated by a sequential chemotherapy.
authors.affiliation: Department of Breast and Thyroid Surgery Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, Japan;
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shimizu
authors.forename: Ayako
authors.initials: A
authors.lastname: Kito
authors.forename: Ikuko
authors.initials: I
authors.lastname: Ota
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sasaki
authors.forename: Mikiko
authors.initials: M
authors.lastname: Tanabe
authors.forename: Akimitsu
authors.initials: A
authors.lastname: Yamada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Arioka
authors.forename: Satoru
authors.initials: S
authors.lastname: Shimizu
authors.forename: Junichi
authors.initials: J
authors.lastname: Wakasugi
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Mori
authors.forename: Takashi
authors.initials: T
authors.lastname: Chishima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Itaru
authors.initials: I
authors.lastname: Endo