title: Characterization and in vivo evaluation of a bio-corrodible nitrided iron stent.
abstract: A bio-corrodible nitrided iron stent was developed using a vacuum plasma nitriding technique. In the nitrided iron stents, the tensile strength, radial strength, stiffness and in vitro electrochemical corrosion rate were significantly increased compared with those of the control pure iron stent. To evaluate its performance in vivo, the deployment of the nitrided iron stents in juvenile pig iliac arteries was performed. At 3 or 6 months postoperatively, the stented vessels remained patent well; however, slight luminal loss resulting from intimal hyperplasia and relative stenosis of the stented vessel segment with piglets growth were observed by 12 months; no thrombosis or local tissue necrosis was found. At 1 month postoperatively, a nearly intact layer of endothelial cells formed on the stented vessel wall. Additionally, a decreased inflammation scoring, considerably corroded struts and corrosion products accumulation were seen. These findings indicate the potential of this nitrided iron stent as an attractive biodegradable stent.
authors.affiliation: Department of Cardiology, Shanghai Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Qimao
authors.initials: Q
authors.lastname: Feng
authors.forename: Deyuan
authors.initials: D
authors.lastname: Zhang
authors.forename: Chaohua
authors.initials: C
authors.lastname: Xin
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Liu
authors.forename: Wenjiao
authors.initials: W
authors.lastname: Lin
authors.forename: Wanqian
authors.initials: W
authors.lastname: Zhang
authors.forename: Sun
authors.initials: S
authors.lastname: Chen
authors.forename: Kun
authors.initials: K
authors.lastname: Sun
mesh_terms: D000792:Angiography; D000818:Animals; D001672:Biocompatible Materials; D055664:Electrochemical Techniques; D004730:Endothelium, Vascular / Q000254:growth & development; D007501:Iron / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D015607:Stents; D013552:Swine; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D007501:Iron