title: [The MG-QOL15 Japanese version: validation and associations with clinical factors].
abstract: We produced a Japanese translation of the 15-item myasthenia gravis (MG)-specific quality of life (QOL) scale (MG-QOL15), assessed its reliability and validity, and examined clinical factors affecting the self-perceived QOL in MG. Consecutive 327 patients with MG seen at six neurological centers were evaluated. All patients completed an MG-QOL15 Japanese version (MG-QOL15-J), the Beck Depression Inventory-Second Edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the MG Foundation of America (MGFA) quantitative MG score and the MG composite. The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA postintervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL. The MG-QOL15-J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG.
authors.affiliation: Department of Neurology, Tokyo Medical University.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Masuda
authors.forename: Kimiaki
authors.initials: K
authors.lastname: Utsugisawa
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Nagane
authors.forename: Suguru
authors.initials: S
authors.lastname: Ito
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kabasawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Hiroya
authors.initials: H
authors.lastname: Utsumi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Fujihara
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Uchiyama
authors.forename: Norihiro
authors.initials: N
authors.lastname: Suzuki
mesh_terms: D006801:Humans; D009157:Myasthenia Gravis / Q000523:psychology*; D011788:Quality of Life; D011795:Surveys and Questionnaires