title: [EGFR activating mutation in lung adenocarcinoma: risk factor of thromboembolic event?].
abstract: Cancer is a known risk factor for the development of venous thromboembolism (VTE) and in particular, adenocarcinoma of the lung is known to be associated with a higher risk of thromboembolic event. EGFR activating mutations are more frequently found in this histological subtype than in other lung cancers. We report three cases of VTE in patients with adenocarcinoma of the lung and EGFR activating mutation. Our reported case series is atypical because the VTE event occurred early in the adenocarcinoma history: either leading to the diagnosis of cancer, or appearing very early in the management of the neoplasm.
authors.affiliation: Service d'oncologie thoracique, hôpital Cavale Blanche, CHU Morvan-Brest, boulevard Tanguy-Prigent, Brest cedex, France. elise.ns@gmail.com
authors.forename: E
authors.initials: E
authors.lastname: Noël-Savina
authors.forename: N
authors.initials: N
authors.lastname: Paleiron
authors.forename: G
authors.initials: G
authors.lastname: Le Gal
authors.forename: R
authors.initials: R
authors.lastname: Descourt
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics*; D004789:Enzyme Activation / Q000235:genetics; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D005260:Female; D018773:Genes, erbB-1; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D020125:Mutation, Missense; D016273:Occupational Exposure; D017354:Point Mutation; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D012307:Risk Factors; D017384:Sequence Deletion; D012907:Smoking / Q000009:adverse effects; D019851:Thrombophilia / Q000209:etiology / Q000235:genetics; D014463:Ultrasonography; D054556:Venous Thromboembolism / Q000453:epidemiology; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology*; D014842:von Willebrand Diseases / Q000150:complications
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; C512478:EGFR protein, human; D066246:ErbB Receptors