title: Impregnation with antimicrobials has an impact on degree of conversion and colour stability of acrylic liner.
abstract: This study investigated the impact of impregnation of a poly(ethyl methacrylate) /tetrahydrofurfuryl methacrylate (PEM/THFM) polymer with chlorhexidine or fluconazole on the degree of conversion (DC) and colour stability (ΔE). The DC of uncured (0 h) and cured (24 h) samples was analysed by Fourier transform infrared spectroscopy (FTIR) and colour stability was analysed colorimetrically. The DC percentage of the control samples was significantly greater than those containing chlorhexidine and fluconazole (p≤0.05). The control discs exhibited only slight colour change compared to the impregnated discs which showed marked colour change (p≤0.05). A strong negative correlation between the extent of colour change and the degree of conversion was detected (r=0.97). The DC and colour stability were influenced by the addition of chlorhexidine or fluconazole. However, the final values were comparable to other commonly used acrylic liners and within acceptable ranges. PEM/THFM can be considered as a biocompatible drug delivery system.
authors.affiliation: The University of Manchester, School of Dentistry, Higher Cambridge Street, Manchester M15 6FH, United Kingdom.
authors.forename: Nesreen
authors.initials: N
authors.lastname: Salim
authors.forename: Julian
authors.initials: J
authors.lastname: Satterthwaite
authors.forename: Riina
authors.initials: R
authors.lastname: Rautemaa
authors.forename: Nick
authors.initials: N
authors.lastname: Silikas
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry; D002710:Chlorhexidine / Q000737:chemistry; D003116:Color; D003764:Dental Materials / Q000737:chemistry*; D003822:Denture Liners; D004338:Drug Combinations; D016503:Drug Delivery Systems; D015725:Fluconazole / Q000737:chemistry; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D008768:Methylmethacrylates / Q000737:chemistry; D058105:Polymerization; D011109:Polymethacrylic Acids / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000180:Acrylic Resins; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D003764:Dental Materials; D004338:Drug Combinations; D008689:Methacrylates; D008768:Methylmethacrylates; D011109:Polymethacrylic Acids; C092890:tetrahydrofurfuryl methacrylate; C030613:polymethacrylic acid; D015725:Fluconazole; C009931:poly(ethylmethacrylate); D002710:Chlorhexidine