title: Prevalence of human papillomavirus in the cervical epithelium of Mexican women: meta-analysis.
abstract: BACKGROUND
  Human Papillomavirus (HPV) in cervical epithelium has been identified as the main etiological factor in the developing of Cervical Cancer (CC), which has recently become a public health problem in Mexico. This finding has allowed for the development of vaccines that help prevent this infection. In the present study, we aimed to determine the prevalence and HPV type-distribution in Mexican women with CC, high-grade squamous intraepithelial lesion (HSIL), low-grade squamous intraepithelial lesion (LSIL), and Normal cytology (N) to estimate the impact of the HPV vaccines.
  
  
  METHODS
  The PubMed database was used to identify and review all articles that reported data on HPV prevalence in CC, precursor lesions, and normal cytology of Mexican women.
  
  
  RESULTS
  A total of 8,706 samples of the tissues of Mexican women were stratified according to diagnosis as follows: 499 for CC; 364 for HSIL; 1,425 for LSIL, and 6,418 for N. According to the results, the most prevalent genotypes are the following: HPV16 (63.1%), -18 (8.6%), -58, and -31 (5%) for CC; HPV-16 (28.3%), 58 (12.6%), 18 (7.4%), and 33 (6.5%) for HSIL; HPV-16 (13.1%), 33 (7.4%), 18 (4.2%), and 58 (2.6%) for LSIL, and HPV-16 (3.4%), 33 (2.1%), 18, and 58 (1.2%) for N.
  
  
  CONCLUSIONS
  Taken together, genotypes 58 and 31 (10%) are more common than type 18 (8.6%) in CC. Therefore, the inclusion of these two genotypes in a second-generation vaccine would provide optimal prevention of CC in Mexico.
authors.affiliation: Laboratorio de Oncología Genómica, Unidad de Investigación Médica en Enfermedades Oncológicas, Hospital de Oncología, CMN SXXI-IMSS, Av, Cuauhtémoc 330, Col, Doctores, México, Distrito Federal 06720, México. maosal89@yahoo.com.
authors.forename: Raúl
authors.initials: R
authors.lastname: Peralta-Rodríguez
authors.forename: Pablo
authors.initials: P
authors.lastname: Romero-Morelos
authors.forename: Vanessa
authors.initials: V
authors.lastname: Villegas-Ruíz
authors.forename: Mónica
authors.initials: M
authors.lastname: Mendoza-Rodríguez
authors.forename: Keiko
authors.initials: K
authors.lastname: Taniguchi-Ponciano
authors.forename: Beatriz
authors.initials: B
authors.lastname: González-Yebra
authors.forename: Daniel
authors.initials: D
authors.lastname: Marrero-Rodríguez
authors.forename: Mauricio
authors.initials: M
authors.lastname: Salcedo