title: Effectiveness of nicardipine for blood pressure control in patients with subarachnoid hemorrhage.
abstract: OBJECTIVE
  The purpose of the study is to determine the effectiveness and safety of nicardipine infusion for controlling blood pressure in patients with subarachnoid hemorrhage (SAH).
  
  
  METHODS
  We prospectively evaluated 52 patients with SAH and treated with nicardipine infusion for blood pressure control in a 29 months period. The mean blood pressure of pre-injection, bolus injection and continuous injection period were compared. This study evaluated the effectiveness of nicardipine for each Fisher grade, for different dose of continuous nicardipine infusion, and for the subgroups of systolic blood pressure.
  
  
  RESULTS
  The blood pressure measurement showed that the mean systolic blood pressure / diastolic blood pressure (SBP/DBP) in continuous injection period (120.9/63.0 mmHg) was significantly lower than pre-injection period (145.6/80.3 mmHg) and bolus injection period (134.2/71.3 mmHg), and these were statistically significant (p < 0.001). In each subgroups of Fisher grade and different dose, SBP/DBP also decreased after the use of nicardipine. These were statistically significant (p < 0.05), but there was no significant difference in effectiveness between subgroups (p > 0.05). Furthermore, controlling blood pressure was more effective when injecting higher dose of nicardipine in higher SBP group rather than injecting lower dose in lower SBP group, and it also was statistically significant (p < 0.05). During the infusion, hypotension and cardiogenic problems were transiently combined in five cases. However, patients recovered without any complications.
  
  
  CONCLUSIONS
  Nicardipine is an effective and safe agent for controlling acutely elevated blood pressure after SAH. A more systemic study with larger patients population will provide significant results and will bring solid evidence on effectiveness of nicardipine in SAH.
authors.affiliation: Department of Neurosurgery, Eulji University Hospital, Daejeon, Korea.
authors.forename: Sang Yong
authors.initials: SY
authors.lastname: Kim
authors.forename: Seong Min
authors.initials: SM
authors.lastname: Kim
authors.forename: Moon Sun
authors.initials: MS
authors.lastname: Park
authors.forename: Han Kyu
authors.initials: HK
authors.lastname: Kim
authors.forename: Ki Seok
authors.initials: KS
authors.lastname: Park
authors.forename: Seong Young
authors.initials: SY
authors.lastname: Chung