title: Can platelet-rich plasma (PRP) improve bone healing? A comparison between the theory and experimental outcomes.
abstract: The increased concentration of platelets within platelet-rich plasma (PRP) provides a vehicle to deliver supra-physiologic concentrations of growth factors to an injury site, possibly accelerating or otherwise improving connective tissue regeneration. This potential benefit has led to the application of PRP in several applications; however, inconsistent results have limited widespread adoption in bone healing. This review provides a core understanding of the bone healing mechanisms, and corresponds this to the factors present in PRP. In addition, the current state of the art of PRP preparation, the key aspects that may influence its effectiveness, and treatment outcomes as they relate specifically to bone defect healing are presented. Although PRP does have a sound scientific basis, its use for bone healing appears only beneficial when used in combination with osteoconductive scaffolds; however, neither allograft nor autograft appear to be appropriate carriers. Aggressive processing techniques and very high concentrations of PRP may not improve healing outcomes. Moreover, many other variables exist in PRP preparation and use that influence its efficacy; the effect of these variables should be understood when considering PRP use. This review includes the essentials of what has been established, what is currently missing in the literature, and recommendations for future directions.
authors.affiliation: Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School, The University of New South Wales, Sydney, Australia. angadmalhotra@live.com
authors.forename: Angad
authors.initials: A
authors.lastname: Malhotra
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Pelletier
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: William R
authors.initials: WR
authors.lastname: Walsh
mesh_terms: D001792:Blood Platelets / Q000502:physiology; D001842:Bone and Bones / Q000503:physiopathology*; D017102:Fracture Healing / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D053657:Platelet-Rich Plasma / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins