title: The change of functional connectivity specificity in rats under various anesthesia levels and its neural origin.
abstract: Spatiotemporal correlations of spontaneous blood oxygenation level dependent (BOLD) signals measured in the resting brain have been found to imply many resting-state coherent networks under both awake/conscious and anesthetized/unconscious conditions. To understand the resting-state brain networks in the unconscious state, spontaneous BOLD signals from the rat sensorimotor cortex were studied across a wide range of anesthesia levels induced by isoflurane. Distinct resting-state networks covering functionally specific sub-regions of the sensorimotor system were observed under light anesthesia with 1.0% isoflurane; however, they gradually merged into a highly synchronized and spatially less-specific network under deep anesthesia with 1.8% isoflurane. The EEG power correlations recorded using three electrodes from a separate group of rats showed similar dependency on anesthesia depth, suggesting the neural origin of the change in functional connectivity specificity. The specific-to-less-specific transition of resting-state networks may reflect a functional reorganization of the brain at different anesthesia levels or brain states.
authors.affiliation: Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, 2021 6th St. SE, Minneapoli, MN 55455, USA.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Zhu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000098:blood supply / Q000187:drug effects*; D001931:Brain Mapping; D058256:Brain Waves / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D007839:Functional Laterality; D007091:Image Processing, Computer-Assisted; D007530:Isoflurane / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000098:blood supply / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D012044:Regression Analysis
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane; D010100:Oxygen