title: Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.
abstract: Since age-dependent deposition of Aβ-amyloid has been reported in the Microcebusmurinus, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of Aβ-amyloid, α-synuclein and two of its modified forms in the brain of Microcebusmurinus aged from 1.5 to 10 years. Intracytoplasmic α-synuclein aggregates were observed only in aged animals in different brain regions, which were also phospho-Ser129 and nitrated α-synuclein immunoreactive. Age-dependent α-synuclein aggregation occurs spontaneously in mouse lemur primates. Microcebus murinus may provide a model to study age-associated α-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases.
authors.affiliation: Univ. de Bordeaux, Institut des Maladies Neurodégénératives , UMR 5293, F-33000 Bordeaux, France.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Canron
authors.forename: Martine
authors.initials: M
authors.lastname: Perret
authors.forename: Anne
authors.initials: A
authors.lastname: Vital
authors.forename: Erwan
authors.initials: E
authors.lastname: Bézard
authors.forename: Benjamin
authors.initials: B
authors.lastname: Dehay
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001931:Brain Mapping; D016565:Cheirogaleidae; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology; D010766:Phosphorylation; D017510:Protein Folding; D051844:alpha-Synuclein / Q000737:chemistry / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D051844:alpha-Synuclein