title: Iridium-catalyzed enantioselective polyene cyclization.
abstract: A highly enantioselective polycyclization method has been developed using the combination of Lewis acid activation with iridium-catalyzed allylic substitution. This strategy relies on direct use of branched, racemic allylic alcohols and furnishes a diverse and unique set of carbo- and heteropolycyclic ring systems in good yields and ≥99% ee.
authors.affiliation: Eidgenössische Technische Hochschule Zürich, HCI H335, 8093 Zürich, Switzerland.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Schafroth
authors.forename: David
authors.initials: D
authors.lastname: Sarlah
authors.forename: Simon
authors.initials: S
authors.lastname: Krautwald
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007495:Iridium / Q000737:chemistry*; D011090:Polyenes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D011090:Polyenes; D007495:Iridium