title: [Space flight/bedrest immobilization and bone. Medical treatment for immobilization osteoporosis].
abstract: Immobilization or unloading results in rapid bone loss by both enhanced bone resorption and suppressed bone formation. Bisphosphonates have been used to treat immobilization osteoporosis to suppress increased bone resorption. Recently, parathyroid hormone and anti-sclerostin antibody have been shown to enhance bone formation in immobilized or unloaded animal models. It is possible that these anabolic agents will be good alternatives for immobilization osteoporosis.
authors.affiliation: Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Seiji
authors.initials: S
authors.lastname: Fukumoto
mesh_terms: D045930:Anabolic Agents / Q000627:therapeutic use; D001510:Bed Rest / Q000009:adverse effects*; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D007103:Immobilization / Q000009:adverse effects; D010024:Osteoporosis / Q000188:drug therapy*; D010281:Parathyroid Hormone / Q000627:therapeutic use
chemical_list: D045930:Anabolic Agents; D004164:Diphosphonates; D010281:Parathyroid Hormone