title: Study on epidemiology of cutaneous amyloidosis in northern India and effectiveness of dimethylsulphoxide in cutaneous amyloidosis.
abstract: BACKGROUND
  Amyloidosis, which is characterized by the extracellular deposition of a proteinaceous substance, is usually associated with considerable tissue dysfunction. However, the etiology of the disease remains uncertain and the treatment disappointing.
  
  
  OBJECTIVE
  1. To know the epidemiology of cutaneous amyloidosis 2. To evaluate the effect of dimethylsulphoxide on cutaneous amyloidosis.
  
  
  METHODS
  Data was collected from patients attending the Outpatient Department (OPD) over a period of one year.
  
  
  METHODS
  Patients were screened on the basis of signs and symptoms and then confirmed histologically. A total of 62 patients who were suspected to be suffering from amyloidosis on the basis of clinical signs and symptoms and 38 patients who were further confirmed histopathologically underwent the treatment.
  
  
  METHODS
  Chi-square test was used for testing the significance of proportions.
  
  
  RESULTS
  63.15 percent of the patients had macular amyloidosis and the interscapular area was the most common area involved (52.63%). Pruritus, pigmentation, and papules responded excellently to dimethylsulphoxide after one month of treatment.
  
  
  CONCLUSIONS
  Cutaneous amyloidosis is a disease found in middle-aged persons, with a female preponderance, and dimethylsulphoxide seems to be an effective therapy.
authors.affiliation: Department of Skin and VD, Subharti Medical College, India.
authors.forename: Arvind
authors.initials: A
authors.lastname: Krishna
authors.forename: Bhola
authors.initials: B
authors.lastname: Nath
authors.forename: G G
authors.initials: GG
authors.lastname: Dhir
authors.forename: Ranjeeta
authors.initials: R
authors.lastname: Kumari
authors.forename: Virendra
authors.initials: V
authors.lastname: Budhiraja
authors.forename: Kalpana
authors.initials: K
authors.lastname: Singh