title: Well-defined degradable cationic polylactide as nanocarrier for the delivery of siRNA to silence angiogenesis in prostate cancer.
abstract: Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes. The CPLAs possess remarkable hydrolytic degradability, and their cytotoxicity is relatively low. The CPLA-IL-8 siRNA nanoplexes can be readily taken up by prostate cancer cells, resulting in significant IL-8 gene silencing. It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA-IL-8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs.
authors.affiliation: Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260-4200, USA.
authors.forename: Chih-Kuang
authors.initials: CK
authors.lastname: Chen
authors.forename: Wing-Cheung
authors.initials: WC
authors.lastname: Law
authors.forename: Ravikumar
authors.initials: R
authors.lastname: Aalinkeel
authors.forename: Bindukumar
authors.initials: B
authors.lastname: Nair
authors.forename: Atcha
authors.initials: A
authors.lastname: Kopwitthaya
authors.forename: Supriya D
authors.initials: SD
authors.lastname: Mahajan
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Reynolds
authors.forename: Jiong
authors.initials: J
authors.lastname: Zou
authors.forename: Stanley A
authors.initials: SA
authors.lastname: Schwartz
authors.forename: Paras N
authors.initials: PN
authors.lastname: Prasad
authors.forename: Chong
authors.initials: C
authors.lastname: Cheng
mesh_terms: D020341:Absorbable Implants; D045744:Cell Line, Tumor; D020868:Gene Silencing; D006801:Humans; D008297:Male; D053769:Nanocapsules / Q000737:chemistry*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000628:therapy*; D011073:Polyamines / Q000737:chemistry; D000071228:Polyelectrolytes; D011091:Polyesters / Q000737:chemistry*; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000628:therapy*; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000235:genetics
chemical_list: D053769:Nanocapsules; D011073:Polyamines; D000071228:Polyelectrolytes; D011091:Polyesters; D034741:RNA, Small Interfering; C033616:poly(lactide)