title: Size-controlled and biocompatible Gd2 O3 nanoparticles for dual photoacoustic and MR imaging.
abstract: The synthesis, characterization, and functional evaluation of new size-controlled and biocompatible Gd(2) O(3)  nanoparticles as a bimodal contrast agent for use in photoacoustic (PA) and magnetic resonance (MR) imaging are reported. These nanoparticles show a clear PA image by themselves, without conjugation with gold, rare earth metals, or dyes. Relaxivity measurement by MR imaging clearly shows that their relaxivity, r(1) , is twice that of clinically available Gd-DTPA.
authors.affiliation: Advanced Biomedical Engineering Research Unit, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Kimura
authors.forename: Ryota
authors.initials: R
authors.lastname: Kamisugi
authors.forename: Michiko
authors.initials: M
authors.lastname: Narazaki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Matsuda
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tabata
authors.forename: Akio
authors.initials: A
authors.lastname: Toshimitsu
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Kondo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis; D003287:Contrast Media / Q000138:chemical synthesis; D005682:Gadolinium / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D061088:Photoacoustic Techniques / Q000379:methods*; D013382:Subtraction Technique
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; C030581:gadolinium oxide; D005682:Gadolinium