title: Anti-HIV activity of flavonoids and proanthocyanidins from Crataegus sinaica.
abstract: In addition to quercetin, hyperoside, rutin, vitexin, 2″-O-rhamnosylvitexin, (4″'-O-acetyl)-2″-O-rhamno-sylvitexin, epicatechin, procyanidin B-5, proanthocyanidin A-2, procyanidin B-2 and procyanidin C-1, which were reported before in Crataegus sinaica (Rosaceae), three more flavonoids were isolated from the same plant, i.e. (+)-taxifolin, 3-O-β-arabinopyranosyl-(+)-taxifolin and 3-0-β-xylopyranosyl-(+)-taxifolin. The in vitro anti-HIV activity of some selected flavonoids and proanthocyanidins was evaluated. The dimeric procyanidin B2 and proanthocyanidin A2, and especially the trimeric procyanidin C1 showed some in vitro anti-HIV activity.
authors.affiliation: Pharmaceutical Sciences Department, NRC, Cairo, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: Shahat
authors.forename: S I
authors.initials: SI
authors.lastname: Ismail
authors.forename: F M
authors.initials: FM
authors.lastname: Hammouda
authors.forename: S A
authors.initials: SA
authors.lastname: Azzam
authors.forename: G
authors.initials: G
authors.lastname: Lemière
authors.forename: T
authors.initials: T
authors.lastname: De Bruyne
authors.forename: S
authors.initials: S
authors.lastname: De Swaef
authors.forename: L
authors.initials: L
authors.lastname: Pieters
authors.forename: A
authors.initials: A
authors.lastname: Vlietinck