title: Squamous cell carcinoma involving the temporal bone:  lateral temporal bone resection as primary intervention.
abstract: OBJECTIVE
  To provide an up-to-date review of treatment and outcomes of patients with squamous cell carcinoma (SCCA) involving the temporal bone.
  
  
  METHODS
  Retrospective cohort study of all patients treated at our institution for SCCA of the temporal bone between 1995 and 2007 with follow-up until 2011. Factors evaluated were demographics, presenting findings, follow-up time, previous treatment, workup, stage, surgical intervention, adjuvant therapy, histopathologic findings, recurrence, and survival.
  
  
  METHODS
  Tertiary care academic medical center.
  
  
  METHODS
  Thirty patients with SCCA of the temporal bone, originating from the external auditory canal and adjacent sites.
  
  
  METHODS
  Surgical resection ± adjuvant therapy. Lateral temporal bone resection was the primary and most aggressive procedure performed.
  
  
  METHODS
  Disease-free survival.
  
  
  RESULTS
  The overall disease free survival for this series when considering both external auditory canal and adjacent site SCCAs was 70%. When evaluated by tumor stage, disease-free survival was as follows: T1 tumors = 100%, T2 tumors = 100%, T3 tumors = 67%, and T4 tumors = 56%. Aggressive tumors of this series originating at periauricular sites behaved in a similar manner to primary canal tumors. Need for surgical resection of CN VII was associated with diminished survival on multivariate analysis.
  
  
  CONCLUSIONS
  Lateral temporal bone resection provides comparable disease free survival rates to more radical surgical therapy. Such resection is appropriate for many SCCAs of the external auditory canal and adjacent sites, as these tumors are similar in disease progression and prognosis. CN VII involvement portends a poor outcome.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA. donat037@umn.edu
authors.forename: Amy Anne D
authors.initials: AA
authors.lastname: Lassig
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Spector
authors.forename: Soheil
authors.initials: S
authors.lastname: Soliman
authors.forename: Hussam K
authors.initials: HK
authors.lastname: El-Kashlan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012888:Skull Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D015996:Survival Rate; D013701:Temporal Bone / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome