title: Design and synthesis of boron containing potential pan-RAR inverse agonists.
abstract: We designed and successfully synthesized the compounds 5 and 8 as potential pan-RAR (retinoic acid receptor) agonists. These two compounds were designed based on an existing pan-RAR agonist (BMS493). We synthesized compound 5, in which the carboxylic acid group in BMS 493 was replaced by boronic ester; and compound 8, in which the double bond of BMS 493 was changed to an oxadiazole (as bioisosteres of double bond) ring. The two target molecules 5 and 8 were synthesized from the commercially available 7-bromo-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one 1. Compound 1 was derivatized to intermediate 5,5-dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalene-2 carbaldehyde 4 by using alkylation, dehydration, and metal exchange reactions. The intermediate 4 was further converted to 5 by using a Wittig reaction and to 8 by amide coupling and dehydration to give overall 18% and 33% yields, respectively, after 8 steps in each case.
authors.affiliation: Department of Surgery, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.
authors.forename: Bhaskar C
authors.initials: BC
authors.lastname: Das
authors.forename: Xiang-Ying
authors.initials: XY
authors.lastname: Tang
authors.forename: Todd
authors.initials: T
authors.lastname: Evans