title: [Chronic pain: medico-biologic and sotsio-economic aspects].
abstract: In this article the role of neurobiological, psychological and social factors in pathogenesis of chronic pain is analyzed. The chronic pain is considered not as a symptom of damage of tissue and as independent illness due to non-adequate neuroplasticity of systems involved into regulation of pain sensitivity. The major role in development and maintenance of chronic pain is devoted to the primary genetically determined and/or secondary disturbance of interaction between nociceptive and antinociceptive systems at various levels--from peripheral neuron to central structures--that provides pain perception and painful behaviour development.
authors.forename: N N
authors.initials: NN
authors.lastname: Iakhno
authors.forename: M L
authors.initials: ML
authors.lastname: Kukushkin
mesh_terms: D059350:Chronic Pain / Q000191:economics / Q000235:genetics / Q000378:metabolism / Q000523:psychology / Q000628:therapy; D017281:Cost of Illness; D006801:Humans; D009431:Neural Conduction / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D059408:Pain Management / Q000379:methods / Q000523:psychology; D058748:Pain Perception / Q000502:physiology; D010348:Patient Care Team; D018434:Sickness Impact Profile; D058992:Social Participation / Q000523:psychology*; D016896:Treatment Outcome