title: Integrin and matrix metalloprotease dual-targeting with an MMP substrate-RGD conjugate.
abstract: A fluorescent clustered RGD-containing ligand encompassing an MMP substrate was designed and successfully used in vivo for the dual-targeting of α(V)β(3) integrin receptors and MMP-9 extracellular proteases in the tumor region.
authors.affiliation: Département de Chimie Moléculaire, CNRS: UMR 5250, ICMG FR 2607, Grenoble cedex 9, France.
authors.forename: Christiane H F
authors.initials: CH
authors.lastname: Wenk
authors.forename: Véronique
authors.initials: V
authors.lastname: Josserand
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumy
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Coll
authors.forename: Didier
authors.initials: D
authors.lastname: Boturyn
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005453:Fluorescence; D057809:HEK293 Cells; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000032:analysis* / Q000096:biosynthesis / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000737:chemistry / Q000175:diagnosis* / Q000378:metabolism*; D009842:Oligopeptides / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D039302:Integrin alphaVbeta3; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; D020780:Matrix Metalloproteinase 9