title: H-InvDB in 2013: an omics study platform for human functional gene and transcript discovery.
abstract: H-InvDB (http://www.h-invitational.jp/) is a comprehensive human gene database started in 2004. In the latest version, H-InvDB 8.0, a total of 244 709 human complementary DNA was mapped onto the hg19 reference genome and 43 829 gene loci, including nonprotein-coding ones, were identified. Of these loci, 35 631 were identified as potential protein-coding genes, and 22 898 of these were identical to known genes. In our analysis, 19 309 annotated genes were specific to H-InvDB and not found in RefSeq and Ensembl. In fact, 233 genes of the 19 309 turned out to have protein functions in this version of H-InvDB; they were annotated as unknown protein functions in the previous version. Furthermore, 11 genes were identified as known Mendelian disorder genes. It is advantageous that many biologically functional genes are hidden in the H-InvDB unique genes. As large-scale proteomic projects have been conducted to elucidate the functions of all human proteins, we have enhanced the proteomic information with an advanced protein view and new subdatabase of protein complexes (Protein Complex Database with quality index). We propose that H-InvDB is an important resource for finding novel candidate targets for medical care and drug development.
authors.affiliation: Integrated Database and Systems Biology Team, Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology, Aomi 2-4-7, Koto-ku, Tokyo 135-0064, Japan.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Takeda
authors.forename: Chisato
authors.initials: C
authors.lastname: Yamasaki
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Murakami
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nagai
authors.forename: Miho
authors.initials: M
authors.lastname: Sera
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hara
authors.forename: Nobuo
authors.initials: N
authors.lastname: Obi
authors.forename: Takuya
authors.initials: T
authors.lastname: Habara
authors.forename: Takashi
authors.initials: T
authors.lastname: Gojobori
authors.forename: Tadashi
authors.initials: T
authors.lastname: Imanishi
mesh_terms: D030541:Databases, Genetic; D005796:Genes; D015894:Genome, Human; D006801:Humans; D020407:Internet; D058977:Molecular Sequence Annotation; D011506:Proteins / Q000235:genetics; D040901:Proteomics; D059467:Transcriptome
chemical_list: D011506:Proteins