title: Mammalian iron homeostasis in health and disease: uptake, storage, transport, and molecular mechanisms of action.
abstract: Iron is a crucial factor for life. However, it also has the potential to cause the formation of noxious free radicals. These double-edged sword characteristics demand a tight regulation of cellular iron metabolism. In this review, we discuss the various pathways of cellular iron uptake, cellular iron storage, and transport. Recent advances in understanding the reduction and uptake of non-transferrin-bound iron are discussed. We also discuss the recent progress in the understanding of transcriptional and translational regulation by iron. Furthermore, we discuss recent advances in the understanding of the regulation of cellular and systemic iron homeostasis and several key diseases resulting from iron deficiency and overload. We also discuss the knockout mice available for studying iron metabolism and the related human conditions.
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Australia. alfons.lawen@monash.edu
authors.forename: Alfons
authors.initials: A
authors.lastname: Lawen
authors.forename: Darius J R
authors.initials: DJ
authors.lastname: Lane
mesh_terms: D000740:Anemia / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D027682:Cation Transport Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D006432:Hemochromatosis / Q000378:metabolism; D064451:Hepcidins / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D059748:Proteolysis; D014168:Transferrin / Q000378:metabolism; D017086:beta-Thalassemia / Q000378:metabolism; D000098742:Ferroportin
chemical_list: D027682:Cation Transport Proteins; D064451:Hepcidins; D014168:Transferrin; D000098742:Ferroportin; D007501:Iron