title: Evaluation of chlorhexidine 0.05% with the adjunct of fluoride 0.05% in the inhibition of plaque formation: a double blind, crossover, plaque regrowth study.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of mouthrinses containing 0.05% chlorhexidine + 0.05% fluoride solution on early dental plaque regrowth.
  
  
  METHODS
  Thirty periodontally healthy subjects were included in the study. A crossover 4-day plaque regrowth protocol was adopted. The test product was initially used in 15 patients, while a placebo was administered to the other 15 patients. Then, after a washout period, each patient used the other product. No other oral hygiene manoeuvre was allowed. Full-mouth plaque and bleeding scores (FMPS and FMBS) were evaluated at baseline and after 4 days.
  
  
  RESULTS
  All subjects completed the study. The mean age was 27 ± 8.4 years. Five patients were smokers with a mean daily consumption of 1 ± 2.5 cigarettes. FMPS at baseline was 8.0 ± 4.4 for control group and 7.9 ± 3.8 for test group, without significant difference. After the 4-day plaque regrowth the mean FMPS significantly increased to 31.9 ± 16.5 and 36.3 ± 16.1 for control and test group, respectively (no significant difference between the two groups).
  
  
  CONCLUSIONS
  The test product was safe and well tolerated by subjects. The similar outcomes of the two experimental groups suggest that the two products have an equivalent effect on early dental plaque regrowth. Studies with longer follow-up are needed to clarify whether there is a beneficial long-term effect of daily rinses with the tested solution.
authors.affiliation: Department of Biomedical, Surgical and Dental Sciences, Centre for Research in Oral Health, IRCCS Istituto Ortopedico Galeazzi, University of Milan, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: De Siena
authors.forename: M
authors.initials: M
authors.lastname: Del Fabbro
authors.forename: S
authors.initials: S
authors.lastname: Corbella
authors.forename: S
authors.initials: S
authors.lastname: Taschieri
authors.forename: R
authors.initials: R
authors.lastname: Weinstein
mesh_terms: D000328:Adult; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D010512:Periodontal Index; D055502:Secondary Prevention; D012907:Smoking; D055815:Young Adult
chemical_list: D004338:Drug Combinations; D009067:Mouthwashes; C010882:chlorhexidine gluconate; D005459:Fluorides; D002710:Chlorhexidine