title: Anti-inflammatory activity of compound D {(E)-4-(3',4'-dimethoxyphenyl)but-3-en-2-ol} isolated from Zingiber cassumunar Roxb.
abstract: Compound D, (E)-4-(3',4'-dimethoxyphenyl)but-3-en-2-ol, is one of many compounds found in the hexane extract of Zingiber cassumunar Roxb. The anti-inflammatory activity of compound D was assessed using various inflammatory models in comparison with aspirin, indomethacin and prednisolone. The results obtained showed that the anti-inflammatory effect of compound D mediated prominently on the acute phase of inflammation. It exerted marked inhibition on carrageenin-induced rat paw edema as well as on the exudate formation, leukocyte accumulation and prostaglandin biosynthesis in carrageenin-induced rat pleurisy. Compound D possessed only slight inhibition on both primary and secondary lesions of adjuvant-induced arthritis and had no effect on cotton pellet-induced granuloma. Compound D elicited analgesic activity when tested on acetic acid-induced writhing response in mice but had weak inhibitory activity on tail flick responding to radiant heat. Compound D possessed marked antipyretic effect when tested on yeast-induced hyperthermia in rats.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: A
authors.initials: A
authors.lastname: Panthong
authors.forename: D
authors.initials: D
authors.lastname: Kanjanapothi
authors.forename: W
authors.initials: W
authors.lastname: Niwatananant
authors.forename: P
authors.initials: P
authors.lastname: Tuntiwachwuttikul
authors.forename: V
authors.initials: V
authors.lastname: Reutrakul