title: Automated synthesis of sialylated oligosaccharides.
abstract: Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules. Our strategy relies on novel sialyl α-(2→3) and α-(2→6) galactosyl imidates, which, used in combination with the automated platform, provided rapid access to a small library of conjugation-ready sialosides of biological relevance.
authors.affiliation: Max-Planck-Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, Germany ; Freie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany.
authors.forename: Davide
authors.initials: D
authors.lastname: Esposito
authors.forename: Mattan
authors.initials: M
authors.lastname: Hurevich
authors.forename: Bastien
authors.initials: B
authors.lastname: Castagner
authors.forename: Cheng-Chung
authors.initials: CC
authors.lastname: Wang
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger