title: Triterpene saponins from Clethra barbinervis and their hyaluronidase inhibitory activities.
abstract: An extract of Clethra barbinervis with an inhibitory effect on hyaluronidase activity was fractionated guided by the results of an assay. From the active fractions, seven new triterpene saponins (1-4, 6-8) and a new lignan glycoside (14) were isolated together with 14 known compounds (5, 9-13, 15-22). Some of the saponins (2, 3, 9) were revealed as hyaluronidase inhibitors similar to epicatechin (17).
authors.affiliation: Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Sendai 981-8558, Japan. murata-t@tohoku-pharm.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Murata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Suzuki
authors.forename: Nagisa
authors.initials: N
authors.lastname: Mafune
authors.forename: Eriko
authors.initials: E
authors.lastname: Sato
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyase
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshizaki
mesh_terms: D031250:Clethraceae / Q000737:chemistry*; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011485:Protein Binding; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D012503:Saponins; D014315:Triterpenes; D006821:Hyaluronoglucosaminidase