title: A hybrid hydrogel biomaterial by nanogel engineering: bottom-up design with nanogel and liposome building blocks to develop a multidrug delivery system.
abstract: New hybrid poly(ethylene glycol) (PEG) hydrogels crosslinked with both nanogels and nanogel-coated liposome complexes are obtained by Michael addition of the acryloyl group of a cholesterol-bearing pullulan (CHP) nanogel to the thiol group of pentaerythritol tetra(mercaptoethyl) polyoxyethylene. The nanogel-coated liposome complex is stably retained after gelation and the complexes are well dispersed in the hybrid gel. Microrheological measurements show that the strength and gelation time of the hybrid hydrogel can be controlled by changing the liposome:nanogel ratio. The hydrogel is gradually degraded by hydrolysis under physiological conditions. In this process, the nanogel is released first, followed by the nanogel-coated liposomes. Hybrid hydrogels that can incorporate various molecules into the nanogel and liposomes, and release them in a two-step controllable manner, represent a new functional scaffold capable of delivering multiple drugs, proteins or DNA.
authors.affiliation: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Yurina
authors.initials: Y
authors.lastname: Sekine
authors.forename: Yuki
authors.initials: Y
authors.lastname: Moritani
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ikeda-Fukazawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Kazunari
authors.initials: K
authors.lastname: Akiyoshi
mesh_terms: D000042:Absorption; D001672:Biocompatible Materials / Q000737:chemistry*; D004058:Diffusion; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000295:instrumentation*; D020100:Hydrogels / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size
chemical_list: D001672:Biocompatible Materials; D004338:Drug Combinations; D020100:Hydrogels; D008081:Liposomes; D053769:Nanocapsules