title: Magnetic nanocomposite sol-gel systems for remote controlled drug release.
abstract: The remote heating of iron oxide nanoparticles in an alternating magnetic field is used to drive a thermoresponsive sol-gel block copolymer, Pluronic® F-127, through the upper phase transition temperature. This phase change triggers an accelerated release rate of a model drug. Actuation and return to baseline levels are demonstrated for multiple AMF doses.
authors.affiliation: Department of Chemical and Materials Engineering, University of Kentucky, 177 F. Paul Anderson Tower, Lexington, KY 40506-0046, USA.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Hawkins
authors.forename: Chelsie E
authors.initials: CE
authors.lastname: Bottom
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liang
authors.forename: David A
authors.initials: DA
authors.lastname: Puleo
authors.forename: J Zach
authors.initials: JZ
authors.lastname: Hilt
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000528:radiation effects*; D005290:Ferric Compounds / Q000737:chemistry* / Q000528:radiation effects; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure; D044367:Phase Transition; D020442:Poloxamer / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D005290:Ferric Compounds; D020442:Poloxamer; C000499:ferric oxide