title: [Comparison of four drug interaction screening programs].
abstract: Adverse drug events (ADE) are a major public health issue, with drug-drug interactions (DDI) being one of well-recognized causes of ADE that could be preventable by the use of DDI screening software. We compared the ability of four programs to detect clinically important DDI. We tested 62 drug pairs with and 12 drug pairs without clinically important DDI. Lexi-Interact and Epocrates were the most sensitive (95%) compared to the Compendium and Theriaque (80 and 73%, respectively). The Compendium and Theriaque also showed the lowest negative predictive value. All programs showed high specificity and positive predictive value. The qualitative assessment showed the best performances for Compendium and Lexi-Interact. The last one seems to be the best screening program, but the Compendium is in French and is freely available.
authors.affiliation: Service de pharmacologie et toxicologie cliniques, HUG, Genève.
authors.forename: K
authors.initials: K
authors.lastname: Ing Lorenzini
authors.forename: B
authors.initials: B
authors.lastname: Reutemann
authors.forename: C F
authors.initials: CF
authors.lastname: Samer
authors.forename: B
authors.initials: B
authors.lastname: Guignard
authors.forename: P
authors.initials: P
authors.lastname: Bonnabry
authors.forename: P
authors.initials: P
authors.lastname: Dayer
authors.forename: A
authors.initials: A
authors.lastname: Perrier
authors.forename: J
authors.initials: J
authors.lastname: Desmeules
mesh_terms: D004346:Drug Information Services; D004347:Drug Interactions; D006801:Humans; D012984:Software