title: Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.
abstract: We present a description of retinoblastoma treated with supraselective intra-arterial chemotherapy, demonstrating selective delivery of the infused chemotherapeutic agent into the tumor bed by MRI. A 7-month-old presented with group E (international classification) unilateral retinoblastoma. We treated the patient with several rounds of intra-ophthalmic artery melphalan. Gadolinium was infused along with melphalan to visualize the distribution of this chemotherapeutic drug. Intraoperative MRI was obtained within 15 min after treatment and showed increased enhancement of the tumor and subretinal space. We demonstrate here that supraselective administration of chemotherapy into the ophthalmic artery appears to result in drug delivery to the tumor and subretinal space.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Yale School of Medicine, New Haven, Connecticut, USA.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Materin
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Kuzmik
authors.forename: Paul T
authors.initials: PT
authors.lastname: Jubinsky
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Minja
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Asnes
authors.forename: Ketan R
authors.initials: KR
authors.lastname: Bulsara
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000627:therapeutic use*; D002533:Cerebral Angiography; D003287:Contrast Media / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D005500:Follow-Up Studies; D005682:Gadolinium / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007269:Injections, Intra-Arterial / Q000379:methods*; D007432:Intraoperative Period; D018810:Magnetic Resonance Angiography; D008297:Male; D008558:Melphalan / Q000008:administration & dosage* / Q000627:therapeutic use*; D012161:Retinal Artery; D012163:Retinal Detachment / Q000601:surgery; D019572:Retinal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012175:Retinoblastoma / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003287:Contrast Media; D005682:Gadolinium; D008558:Melphalan