title: Development of the Paris definition of early Crohn's disease for disease-modification trials: results of an international expert opinion process.
abstract: We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD.
authors.affiliation: INSERM U954 and Department of Hepato-Gastroenterology, University Hospital of Nancy, Université Henri Poincaré 1, Vandoeuvre-lès-Nancy, France. peyrinbiroulet@gmail.com
authors.forename: Laurent
authors.initials: L
authors.lastname: Peyrin-Biroulet
authors.forename: Vincent
authors.initials: V
authors.lastname: Billioud
authors.forename: Geert
authors.initials: G
authors.lastname: D'Haens
authors.forename: Remo
authors.initials: R
authors.lastname: Panaccione
authors.forename: Brian
authors.initials: B
authors.lastname: Feagan
authors.forename: Julian
authors.initials: J
authors.lastname: Panés
authors.forename: Silvio
authors.initials: S
authors.lastname: Danese
authors.forename: Stefan
authors.initials: S
authors.lastname: Schreiber
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Ogata
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
authors.forename: Peter D R
authors.initials: PD
authors.lastname: Higgins
authors.forename: Laurent
authors.initials: L
authors.lastname: Beaugerie
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Chowers
authors.forename: Edouard
authors.initials: E
authors.lastname: Louis
authors.forename: Flávio
authors.initials: F
authors.lastname: Steinwurz
authors.forename: Walter
authors.initials: W
authors.lastname: Reinisch
authors.forename: Paul
authors.initials: P
authors.lastname: Rutgeerts
authors.forename: Jean-Frédéric
authors.initials: JF
authors.lastname: Colombel
authors.forename: Simon
authors.initials: S
authors.lastname: Travis
authors.forename: William J
authors.initials: WJ
authors.lastname: Sandborn
mesh_terms: D002986:Clinical Trials as Topic; D003210:Concept Formation; D032921:Consensus; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D018450:Disease Progression; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis; D007391:International Cooperation; D012720:Severity of Illness Index; D013997:Time Factors