title: Magnetic scaffolds enriched with bioactive nanoparticles for tissue engineering.
abstract: Novel magnetic fibrin hydrogel scaffolds for cell implantation and tissue engineering are reported. The magnetic scaffolds are produced by the interaction between thrombin-conjugated maghemite nanoparticles of narrow size distribution and fibrinogen. These scaffolds, enriched with growth factor conjugated fluorescent maghemite nanoparticles, provide a supporting 3D environment for massive proliferation of various cell types, and can be successfully visualized by MRI.
authors.affiliation: Department of Chemistry, Bar-Ilan Institute of Nanotechnology and Advanced Materials, Ramat-Gan 52900, Israel. hadas.skaat@gmail.com
authors.forename: Hadas
authors.initials: H
authors.lastname: Skaat
authors.forename: Ofra
authors.initials: O
authors.lastname: Ziv-Polat
authors.forename: Abraham
authors.initials: A
authors.lastname: Shahar
authors.forename: David
authors.initials: D
authors.lastname: Last
authors.forename: Yael
authors.initials: Y
authors.lastname: Mardor
authors.forename: Shlomo
authors.initials: S
authors.lastname: Margel
mesh_terms: D000818:Animals; D002449:Cell Aggregation / Q000502:physiology*; D005290:Ferric Compounds / Q000737:chemistry*; D005337:Fibrin / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D008280:Magnetics; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D051381:Rats; D011917:Rats, Inbred Lew; D023822:Tissue Engineering / Q000295:instrumentation*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D005337:Fibrin