title: Diet supplementation during early lactation with non-alcoholic beer increases the antioxidant properties of breastmilk and decreases the oxidative damage in breastfeeding mothers.
abstract: BACKGROUND
  After delivery and birth, mothers and neonates are exposed to oxidative stress. We tested whether supplementing the diet of breastfeeding mothers with non-alcoholic beer, a product rich in antioxidants, could improve their oxidative status and the antioxidant content of their milk. A prospective trial begun on Day 2 postpartum was conducted in mother-infant dyads.
  
  
  METHODS
  Sixty breastfeeding mothers and their infants were allocated to either a control group (n=30) on a free diet or a study group (n=30) on a free diet supplemented with 660 mL of non-alcoholic beer/day. The oxidative status of the mothers' breastmilk, plasma, and urine and the infant's urine was analyzed on Days 2 and 30 postpartum. The before-after difference was compared within and between the groups.
  
  
  RESULTS
  The increase in antioxidant capacity and coenzyme Q10 content in the breastmilk of the study group at Day 30 was higher than in that of the control group (p<0.001). There was also a change in the oxidative status of the mothers' plasma in the supplemented group regarding the control group; higher values of total antioxidant capacity (p<0.05) and lower levels of 8-hydroxydeoxyguanosine (p<0.05), indicative of DNA oxidative damage, were found. These results indicate a positive effect of non-alcoholic beer supplementation on oxidative stress in mothers. However, no difference in oxidant markers was found in the infant's urine.
  
  
  CONCLUSIONS
  The consumption of non-alcoholic beer appears to enhance the antioxidant capacity of breastmilk and decrease oxidative damage in breastfeeding mothers.
authors.affiliation: Department of Pediatrics, Dr. Peset University Hospital, and Department of Pediatrics, Obstetrics, and Gynecology, University of Valencia, Valencia, Spain. pilar.codoner@uv.es
authors.forename: Pilar
authors.initials: P
authors.lastname: Codoñer-Franch
authors.forename: María T
authors.initials: MT
authors.lastname: Hernández-Aguilar
authors.forename: Almudena
authors.initials: A
authors.lastname: Navarro-Ruiz
authors.forename: Ana B
authors.initials: AB
authors.lastname: López-Jaén
authors.forename: Cintia
authors.initials: C
authors.lastname: Borja-Herrero
authors.forename: Victoria
authors.initials: V
authors.lastname: Valls-Bellés
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001515:Beer; D001942:Breast Feeding / Q000009:adverse effects; D002253:Carbonated Beverages; D019587:Dietary Supplements; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007774:Lactation / Q000378:metabolism*; D008297:Male; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism*; D009035:Mothers; D018384:Oxidative Stress; D059808:Polyphenols; D011446:Prospective Studies; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D000975:Antioxidants; D059808:Polyphenols; D014451:Ubiquinone; C024989:coenzyme Q10