title: No association of genetic variants in BDNF with major depression: a meta- and gene-based analysis.
abstract: Major depressive disorder (MDD) is a complex psychiatric condition with strong genetic predisposition. The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting. In this study, we performed a systematic literature search and conducted random-effects meta-analysis to evaluate genetic variants in BDNF with MDD. A gene-based analysis was also conducted to investigate the cumulative effects of genetic polymorphisms in BDNF. A total of 28 studies from 26 published articles were included in our analysis. Meta-analysis yielded an estimated odds ratio (OR) of 0.96 (95% CI: 0.89-1.05; P = 0.402) for Val66Met (rs6265), 0.83 (95% CI: 0.67-1.04; P = 0.103) for 11757C/G, 1.16 (95% CI: 0.74-1.82; P = 0.527) for 270T/C, 1.03 (95% CI: 0.18-5.75; P = 0.974) for 712A/G and 0.98 (95% CI: 0.85-1.14; P = 0.831) for rs988748. The gene-based analysis indicated that BDNF is not associated with MDD (P > 0.21). Our updated meta- and novel gene-based analyses provide no evidence of the association of BDNF with major depression.
authors.affiliation: Department of Biobehavioral Health, Pennsylvania State University, State College, PA 16801, USA.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Gyekis
authors.forename: Weihong
authors.initials: W
authors.lastname: Yu
authors.forename: Shuqian
authors.initials: S
authors.lastname: Dong
authors.forename: Haina
authors.initials: H
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.forename: Pravina
authors.initials: P
authors.lastname: Kota
authors.forename: Jingyun
authors.initials: J
authors.lastname: Yang
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
chemical_list: D019208:Brain-Derived Neurotrophic Factor