title: Unknown primary Merkel cell carcinoma: 23 new cases and a review.
abstract: BACKGROUND
  Knowledge is limited regarding unknown primary Merkel cell carcinoma (UPMCC).
  
  
  OBJECTIVE
  We sought to document the characteristics and behavior of UPMCC, and determine the most appropriate treatment.
  
  
  METHODS
  A multicenter, retrospective, consecutive study reviewing patients given a diagnosis of UPMCC between 1981 and 2008 was completed. In addition, a literature review of cases of UPMCC was performed.
  
  
  RESULTS
  In all, 23 patients with UPMCC are described and 34 cases from previous reports are compiled. Among the 23 new cases of UPMCC, the average age at diagnosis was 66.0 years; the majority of patients were male (87%) and Caucasian (100% of those reported). One patient was immunosuppressed, and 39% had a history of other cancer. After the initial biopsy, 16 patients had further evaluation of the involved lymph node basin. Half of these had additional positive nodes (8 of 16). The majority of patients had lymph node basin involvement only (78%), whereas 22% had lymph node basin and distant metastasis. The most common lymph node basin involved was inguinal. The median size of the involved lymph node at diagnosis was 5.0 cm. At 2 years, the overall survival of stage IIIB UPMCC was significantly improved versus stage IIIB known primary Merkel cell carcinoma (MCC): 76.9% to 36.4%.
  
  
  CONCLUSIONS
  Limited number of cases and retrospective review are limitations.
  
  
  CONCLUSIONS
  Our data demonstrate improved overall survival in patients with stage IIIB UPMCC versus those with stage IIIB known primary MCC. Because of the unpredictable natural history of UPMCC, we recommend individualization of care based on the details of each patient's clinical presentation.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA. tinatarantola@hotmail.com
authors.forename: Tina I
authors.initials: TI
authors.lastname: Tarantola
authors.forename: Laura A
authors.initials: LA
authors.lastname: Vallow
authors.forename: Michele Y
authors.initials: MY
authors.lastname: Halyard
authors.forename: Roger H
authors.initials: RH
authors.lastname: Weenig
authors.forename: Karen E
authors.initials: KE
authors.lastname: Warschaw
authors.forename: Amy L
authors.initials: AL
authors.lastname: Weaver
authors.forename: Randall K
authors.initials: RK
authors.lastname: Roenigk
authors.forename: Jerry D
authors.initials: JD
authors.lastname: Brewer
authors.forename: Clark C
authors.initials: CC
authors.lastname: Otley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015266:Carcinoma, Merkel Cell / Q000401:mortality* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D018862:Merkel Cells / Q000473:pathology; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000401:mortality* / Q000473:pathology; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology