title: Inhibitory effect of topical adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis.
abstract: BACKGROUND
  Adelmidrol is a semisynthetic derivative of azelaic acid and analogue of the anti-inflammatory compound palmitoylethanolamide (PEA). Based upon its physicochemical properties, adelmidrol is suitable for topical application. The main objective of the present study was to evaluate the efficacy of a topical adelmidrol emulsion on early and late inflammatory responses in hypersensitive dogs. Repeated intradermal injections of Ascaris suum extract were performed in both lateral thoracic areas of six conscious hypersensitive Beagle dogs, topically treated during 8 consecutive days. Adelmidrol (2%) was applied to one side and vehicle to the other. 24 hours after the last antigen challenge, two biopsies (adelmidrol- and vehicle-treated side) were obtained for each dog at the antigen injection site.
  
  
  RESULTS
  A significant reduction in the antigen-induced wheal areas was observed on the 4th and 7th day of adelmidrol treatment. Moreover, cutaneous mast cell numbers were significantly decreased in biopsies obtained after 8 consecutive days of topical adelmidrol treatment.
  
  
  CONCLUSIONS
  The results obtained in the present study show that topical treatment with adelmidrol might represent a new therapeutic tool in controlling the early and late allergic inflammatory skin responses in companion animals.
authors.affiliation: Departament de Farmacología, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Cerrato
authors.forename: Pilar
authors.initials: P
authors.lastname: Brazis
authors.forename: Maria Federica
authors.initials: MF
authors.lastname: Della Valle
authors.forename: Alda
authors.initials: A
authors.lastname: Miolo
authors.forename: Anna
authors.initials: A
authors.lastname: Puigdemont
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001706:Biopsy; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D003998:Dicarboxylic Acids / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D010169:Palmitic Acids / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003998:Dicarboxylic Acids; D010169:Palmitic Acids; C552602:adelmidrol