title: RUNX family: Regulation and diversification of roles through interacting proteins.
abstract: The Runt-related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein-interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX genes in cancer indicates crucial roles for RUNX in tumor suppression. This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses.
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Singapore.
authors.forename: Linda Shyue Huey
authors.initials: LS
authors.lastname: Chuang
authors.forename: Kosei
authors.initials: K
authors.lastname: Ito
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000818:Animals; D002453:Cell Cycle; D050676:Core Binding Factor Alpha 2 Subunit / Q000032:analysis / Q000235:genetics / Q000502:physiology; D050677:Core Binding Factor Alpha 3 Subunit / Q000032:analysis / Q000235:genetics / Q000502:physiology; D050657:Core Binding Factor alpha Subunits / Q000502:physiology*; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000209:etiology*; D011499:Protein Processing, Post-Translational; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D000090742:Serine-Threonine Kinase 3; D015398:Signal Transduction / Q000502:physiology; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D060449:Wnt Signaling Pathway / Q000502:physiology; D000099317:Hippo Kinases
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D050677:Core Binding Factor Alpha 3 Subunit; D050657:Core Binding Factor alpha Subunits; D017346:Protein Serine-Threonine Kinases; D000090742:Serine-Threonine Kinase 3; D016212:Transforming Growth Factor beta; D016159:Tumor Suppressor Protein p53; C097835:STK3 protein, human; D000099317:Hippo Kinases