title: New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.
abstract: CATH version 3.5 (Class, Architecture, Topology, Homology, available at http://www.cathdb.info/) contains 173 536 domains, 2626 homologous superfamilies and 1313 fold groups. When focusing on structural genomics (SG) structures, we observe that the number of new folds for CATH v3.5 is slightly less than for previous releases, and this observation suggests that we may now know the majority of folds that are easily accessible to structure determination. We have improved the accuracy of our functional family (FunFams) sub-classification method and the CATH sequence domain search facility has been extended to provide FunFam annotations for each domain. The CATH website has been redesigned. We have improved the display of functional data and of conserved sequence features associated with FunFams within each CATH superfamily.
authors.affiliation: Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Sillitoe
authors.forename: Alison L
authors.initials: AL
authors.lastname: Cuff
authors.forename: Benoit H
authors.initials: BH
authors.lastname: Dessailly
authors.forename: Natalie L
authors.initials: NL
authors.lastname: Dawson
authors.forename: Nicholas
authors.initials: N
authors.lastname: Furnham
authors.forename: David
authors.initials: D
authors.lastname: Lee
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Lees
authors.forename: Tony E
authors.initials: TE
authors.lastname: Lewis
authors.forename: Romain A
authors.initials: RA
authors.lastname: Studer
authors.forename: Robert
authors.initials: R
authors.lastname: Rentzsch
authors.forename: Corin
authors.initials: C
authors.lastname: Yeats
authors.forename: Janet M
authors.initials: JM
authors.lastname: Thornton
authors.forename: Christine A
authors.initials: CA
authors.lastname: Orengo
mesh_terms: D030562:Databases, Protein; D023281:Genomics; D020407:Internet; D058977:Molecular Sequence Annotation; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D040681:Structural Homology, Protein
chemical_list: D011506:Proteins