title: Remarkable response to photodynamic therapy in residual T4N0M0 nasopharyngeal carcinoma: a case report.
abstract: Local treatment of residual or recurrent nasopharyngeal carcinoma (NPC) is a challenge. Photodynamic therapy (PDT) is an established treatment modality for incurable head and neck carcinoma. Several studies reported induction of an immune response after PDT. We present a patient with residual T4N0M0 NPC who was treated with PDT for residual disease after initial treatment with neo-adjuvant chemotherapy and radiotherapy. Five years after PDT, the tumor did not progress and the patient is still in good condition. We discuss this remarkable long-term response to PDT and speculate on possible mechanisms.
authors.affiliation: Department of Otorhinolaryngology, Gadjah Mada University, Yogyakarta, Indonesia.
authors.forename: S R
authors.initials: SR
authors.lastname: Indrasari
authors.forename: A J
authors.initials: AJ
authors.lastname: Timmermans
authors.forename: M A
authors.initials: MA
authors.lastname: Wildeman
authors.forename: M B
authors.initials: MB
authors.lastname: Karakullukcu
authors.forename: C
authors.initials: C
authors.lastname: Herdini
authors.forename: B
authors.initials: B
authors.lastname: Hariwiyanto
authors.forename: I B
authors.initials: IB
authors.lastname: Tan
mesh_terms: D000328:Adult; D002277:Carcinoma; D006801:Humans; D008297:Male; D008652:Mesoporphyrins / Q000627:therapeutic use*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy*; D020360:Neoadjuvant Therapy; D018365:Neoplasm, Residual / Q000628:therapy; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*
chemical_list: D008652:Mesoporphyrins; D017319:Photosensitizing Agents; C072269:temoporfin