title: Highly enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines.
abstract: By employing a chiral Lewis base as the catalyst, enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines was realized. The reactions proceeded smoothly to afford various chiral 1,2-diarylethanamines with good yields (up to 99%) in good enantioselectivities (up to 98%). Furthermore, one of the products was employed in the synthesis of a pharmaceutical substance.
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiral technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Zheng
authors.forename: Zhouyang
authors.initials: Z
authors.lastname: Xue
authors.forename: Lixin
authors.initials: L
authors.lastname: Liu
authors.forename: Chang
authors.initials: C
authors.lastname: Shu
authors.forename: Weicheng
authors.initials: W
authors.lastname: Yuan
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D058115:Lewis Bases / Q000737:chemistry; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D058115:Lewis Bases; D047428:Protein Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt