title: Recent advances in the diastereoselective Reformatsky-type reaction.
abstract: The classical Reformatsky reaction introduced for the first time in 1887 has been recognized as one among the most useful methods for C-C bond formation. Diastereoselective versions based on the use of chiral auxiliaries as well as enantioselective protocols using chiral ligands have been successfully developed during the last few years. This tutorial review highlights the main recent achievements (since 2004) in the diastereoselective Reformatsky reaction; diastereochemical control has been efficiently achieved using a large variety of chiral auxiliaries to perform the synthesis of specific cyclic and acyclic chiral moieties. The diastereoselective Reformatsky reactions employed in the total synthesis of natural products are also described.
authors.affiliation: Laboratoire de Stéréochimie, CNRS/University of Strasbourg (ECPM), UMR CNRS 7509, 25 Rue Becquerel, 67087 Strasbourg Cedex 2, France.
authors.forename: Sabine
authors.initials: S
authors.lastname: Choppin
authors.forename: Leticia
authors.initials: L
authors.lastname: Ferreiro-Medeiros
authors.forename: Marie
authors.initials: M
authors.lastname: Barbarotto
authors.forename: Francoise
authors.initials: F
authors.lastname: Colobert
mesh_terms: D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008670:Metals / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D008670:Metals