title: Square-wave voltammetric determination of bezafibrate in pharmaceutical formulations using a cathodically pretreated boron-doped diamond electrode.
abstract: The determination of bezafibrate (BZF) using square-wave voltammetry (SWV) and a cathodically pretreated boron-doped diamond electrode is proposed. Cyclic voltammetry results showed one irreversible oxidation peak for BZF at 1.20 V (vs. Ag/AgCl (3.0 mol L(-1) KCl)) in a 0.04 mol L(-1) Britton-Robinson (BR) buffer solution (pH 2.0). Under optimized SWV conditions, a linear analytical curve is obtained for the BZF concentration range 0.10-9.1 μmol L(-1) in the BR buffer solution (pH 2.0), with a detection limit of 0.098 μmol L(-1). The obtained recoveries range from 93.4 to 108%. The proposed novel method was successfully applied in the determination of the BZF content in several pharmaceutical formulations (tablets) and the results are in close agreement (at a 95% confidence level) with those obtained using a comparative spectrophotometric method.
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, C.P. 676, São Carlos-SP 13560-970, Brazil.
authors.forename: Jorge Armando
authors.initials: JA
authors.lastname: Ardila
authors.forename: Elen Romão
authors.initials: ER
authors.lastname: Sartori
authors.forename: Romeu C
authors.initials: RC
authors.lastname: Rocha-Filho
authors.forename: Orlando
authors.initials: O
authors.lastname: Fatibello-Filho
mesh_terms: D001629:Bezafibrate / Q000032:analysis*; D001895:Boron / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D018130:Diamond / Q000737:chemistry*; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D057230:Limit of Detection; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D013607:Tablets / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations; D013607:Tablets; D018130:Diamond; D001895:Boron; D001629:Bezafibrate