title: Chronic autoimmune-mediated inflammation: a senescent immune response to injury.
abstract: The increasing prevalence of chronic autoimmune-mediated inflammatory diseases (AIMIDs) in ageing western societies is a major challenge for the drug development industry. The current high medical need for more-effective treatments is at least in part caused by our limited understanding of the mechanisms that drive chronic inflammation. Here, we postulate a role for immunosenescence in the progression of acute to chronic inflammation via a dysregulated response to primary injury at the level of the damaged target organ. A corollary to this notion is that treatment of acute versus chronic phases of disease might require differential targeting strategies.
authors.affiliation: Department of Immunobiology, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH Rijswijk, The Netherlands. hart@bprc.nl
authors.forename: Bert A
authors.initials: BA
authors.lastname: 't Hart
authors.forename: Paulina
authors.initials: P
authors.lastname: Chalan
authors.forename: Gerrit
authors.initials: G
authors.lastname: Koopman
authors.forename: Annemieke M H
authors.initials: AM
authors.lastname: Boots
mesh_terms: D000375:Aging; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D018106:CD28 Antigens / Q000276:immunology; D002908:Chronic Disease; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D018106:CD28 Antigens