title: [Infection mechanism of enterovirus 71].
abstract: Identification of a specific viral receptor is important for understanding the virus infection mechanism. I identified P-selectin glycoprotein ligand-1 (PSGL-1) as one of the functional receptors for enterovirus 71 (EV71), a pathogen that causes hand, foot, and mouth disease. PSGL-1, which belongs to the sialomucin family, is a transmembrane protein mainly expressed on leukocytes. Tyrosine sulfation in the N-terminal region of PSGL-1 is critical for PSGL-1's capacity to bind EV71. The identification of EV71 receptors provides important mechanistic information about viral entry into cells and helps us understand viral pathogenesis and develop new anti-viral strategies.
authors.affiliation: Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama-shi, Tokyo 208-0011, Japan. ynishi@nih.go.jp
authors.forename: Yorihiro
authors.initials: Y
authors.lastname: Nishimura
mesh_terms: D000818:Animals; D029821:Enterovirus A, Human / Q000378:metabolism* / Q000472:pathogenicity* / Q000502:physiology; D060831:Hand-Foot Syndrome / Q000821:virology; D006801:Humans; D019169:Jurkat Cells / Q000821:virology; D007962:Leukocytes; D008562:Membrane Glycoproteins / Q000302:isolation & purification / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D011485:Protein Binding; D014443:Tyrosine / Q000031:analogs & derivatives; D014779:Virus Replication
chemical_list: D008562:Membrane Glycoproteins; C084882:P-selectin ligand protein; C005662:tyrosine O-sulfate; D014443:Tyrosine