title: [Experimental study on combination attenuation of mutual-detoxication and mutual restraint about Aconiti Carmichaeli Radix].
abstract: OBJECTIVE
  According to the record of mutual-detoxication and mutual restraint in ancient Chinese materia medica, to research the influence to the toxicity of Aconiti Carmichaeli Radix added the traditional Chinese medicine (TCM) which is mutual-detoxication and mutual restraint to it.
  
  
  METHODS
  ICR mouse, 0.4 microL x g(-1), to pour the fluid into stomach, paired comparison of acute toxicity of Aconiti Carmichaeli Radix seperately added different ratio of Sileris Radix, Astragali Radix and Polygalae Radix, and ad-measure the dose for LD50. SD rats, administration by injection through duodenum, 20 microL x g(-1), paired comparison of heart toxicity of Aconiti Carmichaeli Radix seperately added different ratio of Sileris Radix, Astragali Radix and Polygalae Radix, and admeasure the dose for TD50.
  
  
  RESULTS
  LD50, and heart toxicity of TD50 were increased after Aconiti Carmichaeli Radix added separately, its toxicity attenuation is related to the ratio.
  
  
  CONCLUSIONS
  Mutual-detoxication and mutual restraint are the summary drawed when China ancient people is in the process of using toxic TCM and it is scientific.
authors.affiliation: National Engineering Research Center for Traditional Chinese Medicine Compound Drug Development, Beijing 100075, China. iamzgp@163.com
authors.forename: Guangping
authors.initials: G
authors.lastname: Zhang
authors.forename: Suhua
authors.initials: S
authors.lastname: Xie
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Zhu
authors.forename: Siyu
authors.initials: S
authors.lastname: Zhang
authors.forename: Zuguang
authors.initials: Z
authors.lastname: Ye
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000818:Animals; D027883:Astragalus Plant / Q000737:chemistry*; D004339:Drug Compounding; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics* / Q000633:toxicity; D005260:Female; D006321:Heart / Q000187:drug effects; D008658:Inactivation, Metabolic; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D031801:Polygala / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal