title: New loci associated with birth weight identify genetic links between intrauterine             growth and adult height and metabolism.
abstract: Birth weight within the normal range is associated with a variety of adult-onset                 diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified                 a variant in the ADCY5 gene associated both with birth weight and type 2                 diabetes and a second variant, near CCNL1, with no obvious link to adult                     traits. In an expanded genome-wide association meta-analysis and                 follow-up study of birth weight (of up to 69,308 individuals of European descent                 from 43 studies), we have now extended the number of loci associated at genome-wide                 significance to 7, accounting for a similar proportion of variance as maternal                 smoking. Five of the loci are known to be associated with other phenotypes:                     ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult                 blood pressure and HMGA2 and LCORL with adult height. Our findings                 highlight genetic links between fetal growth and postnatal growth and                 metabolism.
authors.affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
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mesh_terms: D000328:Adult; D001724:Birth Weight / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics; D001827:Body Height / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D047109:Fetal Development / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015201:Meta-Analysis as Topic; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci