title: [Necrotizing soft tissue infection of the upper limb].
abstract: Necrotizing soft tissue infections and necrotizing fasciitis are life-threatening infections affecting the hypodermis, muscular fascia, and dermis secondarily. Mortality is high, with an average of 30%. The early diagnosis of necrotizing soft tissue infection is challenging, but is key to successful management of these patients. The mainstay of therapy includes early and wide surgical debridement, antibiotics and supportive care. Adjunctive therapies may have a role, but their effectiveness remains unproven. A review of the literature allows us to highlight this multidisciplinary management.
authors.affiliation: Service de chirurgie plastique, de la main et des brûlés, hôpital Michalon, CHU de Grenoble, 38043 Grenoble, France. AForli@chu-grenoble.fr
authors.forename: A
authors.initials: A
authors.lastname: Forli
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D003646:Debridement; D042241:Early Diagnosis; D019115:Fasciitis, Necrotizing / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D005602:France / Q000453:epidemiology; D006801:Humans; D012307:Risk Factors; D018461:Soft Tissue Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome; D034941:Upper Extremity / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents