title: Controlling and monitoring orientation of DNA nanoconstructs on lipid surfaces.
abstract: Its extraordinary self-assembly property, with potential to form nonperiodic structures with unique addressability, makes DNA ideal for fabrication of advanced nanostructures. We here demonstrate the controllable tethering of a hexagonal DNA nanostructure in two distinct orientations at the lipid bilayer of a liposome functioning as a soft-matter support. With polarized light (linear dichroism) applied to the flow-aligned liposomes, we show that the construct is preferentially in a parallel alignment with the lipid surface when two anchors are attached while with one anchor only a perpendicular orientation is observed.
authors.affiliation: Department of Chemical and Biological Engineering/Physical Chemistry, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.
authors.forename: Erik P
authors.initials: EP
authors.lastname: Lundberg
authors.forename: Bobo
authors.initials: B
authors.lastname: Feng
authors.forename: Amir
authors.initials: A
authors.lastname: Saeid Mohammadi
authors.forename: L Marcus
authors.initials: LM
authors.lastname: Wilhelmsson
authors.forename: Bengt
authors.initials: B
authors.lastname: Nordén
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008051:Lipid Bilayers; D004247:DNA