title: [Pharmacodynamics of water extracts from Atractylodes lancea before and after processing].
abstract: OBJECTIVE
  To study the pharmacological changes of Atractylodes lancea before and after processing and the processing mechanism on the basis of the pharmacological changes.
  
  
  METHODS
  The model of dampness retention in the middle-jiao rats was established to determine small intestine peristalsis rate, GAS level, urine volume and AQP2 content from urine in different groups.
  
  
  RESULTS
  All treatment groups showed increase in small intestinal peristalsis rate and GAS level. The bran-processed group showed significant difference from the negative group. The high dose A. lancea group showed increase in urine volume and decrease in urine AQP2 content in model rats, which were different from the negative group.
  
  
  CONCLUSIONS
  Water extracts from bran-processed A. lancea can obviously increase small intestinal peristalsis and GAS level, indicating that A. lancea has the effect for strengthening spleen and stomach after stir-baking with bran. Its impact on urine and urine AQP2 content in model rats demonstrates that its dryness of A. lancea is alleviated after stir-baking with bran.
authors.affiliation: Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China. lyj1965954@sohu.com
authors.forename: Yanju
authors.initials: Y
authors.lastname: Liu
authors.forename: Wenwen
authors.initials: W
authors.lastname: Chen
authors.forename: Min
authors.initials: M
authors.lastname: Zeng
authors.forename: Kang
authors.initials: K
authors.lastname: Xu
mesh_terms: D000818:Animals; D031174:Atractylodes / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007421:Intestine, Small / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects; D014554:Urination / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal