title: Functionalization of non-activated C-H bonds of alkanes: an effective and recyclable catalytic system based on fluorinated silver catalysts and solvents.
abstract: The complexes F(n)-Tp(4Bo,3Rf)Ag(L) (F(n)-Tp(4Bo,3Rf)=a perfluorinated hydrotris(indazolyl) borate ligand; L=acetone or tetrahydrofuran) efficiently catalyze the functionalization of non-activated alkanes such as hexane, 2,3-dimethylbutane, or 2-methylpentane by insertion of CHCO(2)Et units (from N(2)CHCO(2)Et, ethyl diazoacetate, EDA) into their C-H bonds. The reactions are quantitative (EDA-based), with no byproducts derived from diazo coupling being formed. In the case of hexane, the functionalization of the methyl C-H bonds has been achieved with the highest regioselectivity known to date with this diazo compound. This catalytic system also operates under biphasic conditions by using fluorous solvents such as Fomblin or perfluorophenanthrene. Several cycles of catalyst recovery and reuse have been performed, with identical chemo- and regioselectivities.
authors.affiliation: Laboratorio de Catálisis Homogénea, Departamento de Química y Ciencia de los Materiales, Unidad Asociada al CSIC, Centro de Investigación en Química Sostenible (CIQSO), Campus de El Carmen s/n, Universidad de Huelva, 21007-Huelva, Spain.
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Fuentes
authors.forename: Bianca K
authors.initials: BK
authors.lastname: Muñoz
authors.forename: Kane
authors.initials: K
authors.lastname: Jacob
authors.forename: Laure
authors.initials: L
authors.lastname: Vendier
authors.forename: Ana
authors.initials: A
authors.lastname: Caballero
authors.forename: Michel
authors.initials: M
authors.lastname: Etienne
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Pérez