title: Burden of influenza in Latin America and the Caribbean: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Influenza causes severe morbidity and mortality. This systematic review aimed to assess the incidence, etiology, and resource usage for influenza in Latin America and the Caribbean.
  
  
  METHODS
  Meta-analytic systematic review. Arcsine transformations and DerSimonian Laird random effects model were used for meta-analyses.
  
  
  METHODS
  A literature search from 1980 to 2008 in MEDLINE, Cochrane Library, EMBASE, LILACS, Ministries of Health, PAHO, proceedings, reference lists, and consulting experts.
  
  
  METHODS
  We identified 1092 references, of which 31 were finally included, in addition to influenza surveillance reports. We also used information from the 10 reports from the collaborative group for epidemiological surveillance of influenza and other respiratory virus (GROG), and information retrieved from the WHO global flu database FLUNET.
  
  
  METHODS
  Incidence, percentage of influenza specimens out of the total received by influenza centers and resource-use outcomes.
  
  
  RESULTS
  A total of 483 130 specimens of patients with influenza were analyzed. Meta-analysis showed an annual rate of 36 080 (95%CI 28 550 43 610) influenza-like illness per 100 000 persons-years. The percentage of influenza out of total specimens received by influenza centers ranged between 4.66% and 15.42%, with type A the most prevalent, and A subtype H3 predominating. The mean length of stay at hospital due to influenza ranged between 5.8 12.9 days, total workdays lost due to influenza-like illnesses were 17 150 days, and the mean direct cost of hospitalization was US$575 per laboratory-confirmed influenza case.
  
  
  CONCLUSIONS
  Our data show that seasonal influenza imposes a high morbidity and economic burden to the region. However, the vaccine-uptake rate has been low in this region. Population-based cohort studies are required to improve the knowledge about incidence and resource utilization, which would inform healthcare authorities for decision making.
authors.affiliation: Instituto Nacional de Enfermedades Infecciosas, ANLIS "Dr. Carlos G. Malbran", Buenos Aires, Argentina.Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires, ArgentinaGlaxoSmithKline Biologicals, Rio de Janeiro, Brazil.
authors.forename: Vilma
authors.initials: V
authors.lastname: Savy
authors.forename: Agustín
authors.initials: A
authors.lastname: Ciapponi
authors.forename: Ariel
authors.initials: A
authors.lastname: Bardach
authors.forename: Demián
authors.initials: D
authors.lastname: Glujovsky
authors.forename: Patricia
authors.initials: P
authors.lastname: Aruj
authors.forename: Agustina
authors.initials: A
authors.lastname: Mazzoni
authors.forename: Luz
authors.initials: L
authors.lastname: Gibbons
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ortega-Barría
authors.forename: Rómulo E
authors.initials: RE
authors.lastname: Colindres
mesh_terms: D017691:Caribbean Region / Q000453:epidemiology; D017048:Health Care Costs; D006295:Health Resources / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007251:Influenza, Human / Q000191:economics / Q000453:epidemiology* / Q000821:virology; D007843:Latin America / Q000453:epidemiology; D015995:Prevalence