title: Accessing and mining data from large-scale mouse phenotyping projects.
abstract: Comprehensive phenotyping through the International Mouse Phenotyping Consortium (IMPC)-www.mousephenotype.org-will reveal the pleiotropic functions of every gene in the mouse genome and uncover the wider role of genetic loci within diverse biological systems. The informatics challenge will be to develop an infrastructure to acquire the diverse and complex data sets generated from broad-based phenotyping and disseminate these data in an integrated manner to the scientific community. We describe here the current methodologies implemented to capture and disseminate these data, and plans within the Knockout Mouse Phenotyping Project (KOMP2) (http://commonfund.nih.gov/KOMP2/)-funded informatics consortium to scale these implementations to manage the surge in data from the IMPC.
authors.affiliation: MRC Mammalian Genetics Unit, MRC Harwell, Oxfordshire, OX11 0RD, UK.
authors.forename: Hugh
authors.initials: H
authors.lastname: Morgan
authors.forename: Michelle
authors.initials: M
authors.lastname: Simon
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Mallon
mesh_terms: D000818:Animals; D057225:Data Mining; D016247:Information Storage and Retrieval; D038622:Internationality; D051379:Mice / Q000235:genetics*; D010641:Phenotype