title: Dermatofibrosarcoma protuberans of the mons pubis.
abstract: Dermatofibrosarcoma protuberans (DFSP) is a rare fibrous tumor with intermediate malignant potential and in rare cases the vulva is involved. The most common clinical presentation is a firm plaque with surrounding red to blue discoloration, or less often with multiple small subcutaneous nodules. The authors present a case of a 66-year-old woman who came to the hospital complaining of longstanding painless nodules in the area of the mons pubis. On physical examination, a diffuse area of erythematous induration involving the mons pubis was recognized and within this area there were smaller nodules. The histological diagnosis was dermatofibrosarcoma protuberans. Microscopically DFSP has a storiform pattern of uniform cytologically bland spindle cells, with a characteristic honeycomb pattern of infiltration into the subcutaneous fat. Immunohistochemical staining demonstrates strong positivity for vimentin and CD34. The treatment has been through a wide local excision (WLE), although microscopic tumor projections beyond the central tumor nodule explain the tumors propensity for local recurrence.
authors.affiliation: Department of Pathology, Tzaneion General Hospital of Piraeus, Piraeus, Greece. adserbet@yahoo.gr
authors.forename: A
authors.initials: A
authors.lastname: Zizi-Sermpetzoglou
authors.forename: V
authors.initials: V
authors.lastname: Savvaidou
authors.forename: S
authors.initials: S
authors.lastname: Fournogerakis
authors.forename: E
authors.initials: E
authors.lastname: Moustou
authors.forename: M
authors.initials: M
authors.lastname: Konstantidelli
authors.forename: N
authors.initials: N
authors.lastname: Vlachakos
mesh_terms: D000368:Aged; D018223:Dermatofibrosarcoma / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery