title: Bullous lung disease and neurofibromatosis type-1.
abstract: Lung interstitial diseases and bullae are described as possible complications of neurofibromatosis type-1 (NF-1), a genetic disorder inherited as a autosomal-dominant trait. We report the case of a 16-year-old male non-smoker with NF-1, who presented with pneumothorax caused by ruptured lung bullae. The case of this young patient, successfully treated by video-assisted thoracoscopic resection of bullae, supports the concept that pulmonary alterations may be part of the NF-1 syndrome, rather than as an unrelated complication.
authors.affiliation: Department of Surgical and Morphological Sciences, Thoracic Surgery Unit, Varese University Hospital, University of Insubria, Varese, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Nardecchia
authors.forename: L
authors.initials: L
authors.lastname: Perfetti
authors.forename: M
authors.initials: M
authors.lastname: Castiglioni
authors.forename: D
authors.initials: D
authors.lastname: Di Natale
authors.forename: A
authors.initials: A
authors.lastname: Imperatori
authors.forename: N
authors.initials: N
authors.lastname: Rotolo
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D006801:Humans; D008168:Lung / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000601:surgery; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000175:diagnosis; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed