title: Effect of prophylactic laser iridotomy on corneal endothelial cell density over 3 years in primary angle closure suspects.
abstract: OBJECTIVE
  To assess the effect of prophylactic laser peripheral iridotomy (LPI) on corneal endothelial cell density (ECD) and morphology in primary angle closure suspects (PACS) over 3 years.
  
  
  METHODS
  In this prospective cohort study, subjects underwent LPI in one eye, while the fellow eye was untreated. Specular microscopy was performed at baseline and after 1 and 3 years. Central corneal ECD and morphology of both eyes were assessed using non-contact specular microscopy (Konan SP-9000LC, Konan Inc, Hyogo, Japan).
  
  
  RESULTS
  230 subjects completed 3-year follow-up. The mean age was 62.5 ± 8.0 years, and the majority of subjects were Chinese (92.3%) and women (75.4%). In eyes that underwent LPI, ECD was significantly lower at year 1 (2462.3, 95% CI 2414.5 to 2510.0, p<0.0001) and year 3 (2510.6, 95% CI 2462.1 to 2559.2, p=0.0006) compared with baseline (2609.1, 95% CI 2551.4 to 2666.7). There was also a significant decrease in ECD in fellow untreated eyes from baseline to year 1 (p<0.0001) and year 3 (p=0.01). The decrease in ECD at 3 years compared with the baseline in treated and untreated eyes was similar (2.1% vs 0.9%, p=0.20).
  
  
  CONCLUSIONS
  In PACS eyes, there was decrease in ECD in LPI-treated and control eyes over 3 years, with no significant difference between groups.
authors.affiliation: Singapore National Eye Centre and Singapore Eye Research Institute, Singapore.
authors.forename: Rajesh S
authors.initials: RS
authors.lastname: Kumar
authors.forename: Mani
authors.initials: M
authors.lastname: Baskaran
authors.forename: David S
authors.initials: DS
authors.lastname: Friedman
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.forename: Hon-Tym
authors.initials: HT
authors.lastname: Wong
authors.forename: Raghavan
authors.initials: R
authors.lastname: Lavanya
authors.forename: Paul T
authors.initials: PT
authors.lastname: Chew
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Foster
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
mesh_terms: D002452:Cell Count; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D015812:Glaucoma, Angle-Closure / Q000473:pathology / Q000517:prevention & control / Q000601:surgery*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D007498:Iris / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome