title: Association between fibroblast growth factor receptor 4 Gly388Arg polymorphism and ischaemic stroke.
abstract: OBJECTIVE
  Fibroblast growth factors (FGFs) and their receptors (FGFRs) play important roles in the vascular system. The FGFR4 rs351855 (Gly388Arg) poly morphism has been shown to be a risk factor for many diseases. This case-control study investigated the association between  the FGFR4 Gly388Arg polymorphism and susceptibility to ischaemic stroke in the Chinese population.
  
  
  METHODS
  The FGFR4 Gly388Arg polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in patients with ischaemic stroke and healthy  controls.
  
  
  RESULTS
  Frequencies of genotypes GA and AA, and prevalence of the A allele, were significantly lower in ischaemic stroke patients (n = 952) than in controls (n = 986). Genotype AA and allele A were significantly more frequent in stroke patients with, than in those  without, diabetes.
  
  
  CONCLUSIONS
  These results suggested that the GA genotype, AA genotype and A allele of FGFR4 Gly388Arg polymorphism are all associated with decreased risk of ischaemic stroke in the Chinese population.
authors.affiliation: Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: H F
authors.initials: HF
authors.lastname: Zhang
authors.forename: K J
authors.initials: KJ
authors.lastname: Zhao
authors.forename: P F
authors.initials: PF
authors.lastname: Yang
authors.forename: Y B
authors.initials: YB
authors.lastname: Fang
authors.forename: Y H
authors.initials: YH
authors.lastname: Zhang
authors.forename: J M
authors.initials: JM
authors.lastname: Liu
authors.forename: Q H
authors.initials: QH
authors.lastname: Huang
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000235:genetics*
chemical_list: C496371:FGFR4 protein, human; D051499:Receptor, Fibroblast Growth Factor, Type 4