title: Simultaneous endoscopic submucosal dissection for synchronous double early gastric cancer.
abstract: BACKGROUND
  This study aims to evaluate the safety and efficacy of simultaneous endoscopic submucosal dissection (ESD) for synchronous double early gastric cancers.
  
  
  METHODS
  We retrospectively evaluated 832 single gastric cancers from 789 patients treated by single ESD (single group) and 124 synchronous double cancers from 62 patients treated by simultaneous ESD (simultaneous group).
  
  
  RESULTS
  The overall rate of en bloc resection and curative resection was comparable between the two groups. Procedure time was significantly longer in the simultaneous group than in the single group (131.0 ± 66.5 and 94.8 ± 64.1 min, respectively, P < 0.001). White blood cell count on the day after ESD was significantly higher in the simultaneous group (9310 ± 2774/μl) than in the single group (8633 ± 2341/μl) (P = 0.032). Length of fasting period after ESD was 1.1 ± 0.5 days in the single group and 1.4 ± 1.1 days in the simultaneous group (P = 0.082). Complications were more frequent in the simultaneous group than in the single group (11.3 vs. 5.4 %, respectively), but the difference was not significant (P = 0.082). Complication rate per one lesion did not differ between the two groups (5.6 vs. 5.4 %, respectively, P = 0.914). Multivariate analysis showed procedure time longer than 150 min was independently predictive for complications of simultaneous ESD (P < 0.042, odds ratio = 6.094). Large tumors, upper portion location and tumors not in the standard guideline criteria were significantly associated with long procedure time.
  
  
  CONCLUSIONS
  Simultaneous ESD for synchronous early gastric cancer can be a feasible and safe option, and it can reduce hospital stay. These results need to be validated by further studies.
authors.affiliation: Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo, 135-8550, Japan, akiyoshi_81@hotmail.com.
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Kasuga
authors.forename: Yorimasa
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Junko
authors.initials: J
authors.lastname: Fujisaki
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Okada
authors.forename: Masami
authors.initials: M
authors.lastname: Omae
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Ishiyama
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hirasawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Chino
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Tsuchida
authors.forename: Etsuo
authors.initials: E
authors.lastname: Hoshino
authors.forename: Masahiro
authors.initials: M
authors.lastname: Igarashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*