title: [Observations on human parvovirus B19 infection diagnosed in 2011].
abstract: BACKGROUND
  The incidence of human parvovirus B19 infection is unknown.
  
  
  OBJECTIVE
  A retrospective analysis of clinical and laboratory findings was carried out in patients diagnosed with human parvovirus B19 infection in 2011 in a virologic laboratory of a single centre in Hungary.
  
  
  METHODS
  Clinical and laboratory data of patients with proven human parvovirus B19 infection were analysed using in- and out-patient files.
  
  
  RESULTS
  In 2011, 72 patients proved to have human parvovirus B19 infection with the use of enzyme immunoassay. The clinical diagnoses of these patients were as follows: human parvovirus B19 infection (30.6%), transient aplastic crisis (16.7%), arthritis (8.3%) and acute hepatitis (4.1%). Symptoms of each of the four phases of the infection occurred in various combinations with the exception of the monophase of cheek exanthema. This occurred without the presence of other symptoms in some cases. Leading symptoms and signs were exanthema (in 74.6% of cases), haematological disorders (in 69% of cases), fever (in 54.9% of cases) and arthritis (in 33.8% of cases). Several atypical dermatological symptoms were also observed. Acute arthritis without exanthema was noted in 8 patients. Of the 72 patients with proven human parvovirus B19 infection there were 7 pregnant women, and one of them had hydrops foetalis resulting spontaneous abortion. In 16 patients (22.5%) human parvovirus B19 IgG was undetectable despite an optimal time for testing.
  
  
  CONCLUSIONS
  The observations of this study may contribute to a better recognition of clinical symptoms of human parvovirus B19 infection.
authors.affiliation: Egyesített Szent István és Szent László Kórház-Rendelőintézet Mikrobiológiai Laboratóriumi Osztály, Virológiai Laboratórium Budapest. mihalylona@gmail.com
authors.forename: Ilona
authors.initials: I
authors.lastname: Mihály
authors.forename: András
authors.initials: A
authors.lastname: Trethon
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Arányi
authors.forename: Adrienne
authors.initials: A
authors.lastname: Lukács
authors.forename: Tímea
authors.initials: T
authors.lastname: Kolozsi
authors.forename: Gyula
authors.initials: G
authors.lastname: Prinz
authors.forename: Anikó
authors.initials: A
authors.lastname: Marosi
authors.forename: Nóra
authors.initials: N
authors.lastname: Lovas
authors.forename: Ilona Sarolta
authors.initials: IS
authors.lastname: Dobner
authors.forename: Géza
authors.initials: G
authors.lastname: Prinz
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Szalai
authors.forename: Tamás
authors.initials: T
authors.lastname: Pék
mesh_terms: D000022:Abortion, Spontaneous / Q000821:virology; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000302:isolation & purification; D001168:Arthritis / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D016731:Erythema Infectiosum / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology; D016732:Parvovirus B19, Human / Q000276:immunology / Q000302:isolation & purification* / Q000472:pathogenicity; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology; D012189:Retrospective Studies
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M