title: Total synthesis of (-)-chamobtusin A.
abstract: The first asymmetric total synthesis of a structurally unique alkaloid, chamobtusin A (1), is described. The route features a novel aziridine formation from the 1,2-oxazine derivative and a palladium-mediated annulation of the vinylaziridine intermediate.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Suzuki
authors.forename: Sakae
authors.initials: S
authors.lastname: Aoyagi
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D004224:Diterpenes; C525487:chamobtusin A; D010165:Palladium