title: Performance of the first fourth-generation rapid human immunodeficiency virus test in children.
abstract: Diagnosing HIV infection in infants by p24 antigen detection at point of care is likely to reduce infant morbidity and mortality. A fourth-generation rapid test evaluated on 202 stored samples from children of known age and clinical presentation demonstrated a sensitivity of <2% for detecting p24 antigen in 61 HIV-infected infants and demonstrated 100% sensitivity and specificity for detecting HIV antibodies in infants aged 6 months and younger.
authors.affiliation: Paediatric HIV Diagnostic Syndicate, Wits Health Consortium, Parktown, South Africa. kbhowan@gmail.com
authors.forename: Kapila
authors.initials: K
authors.lastname: Bhowan
authors.forename: Gayle G
authors.initials: GG
authors.lastname: Sherman
mesh_terms: D016655:HIV Core Protein p24 / Q000097:blood*; D015658:HIV Infections / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D019095:Point-of-Care Systems; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D014773:Virology / Q000379:methods*
chemical_list: D016655:HIV Core Protein p24; D011933:Reagent Kits, Diagnostic