title: Latent TGF-β hydrogels for cartilage tissue engineering.
abstract: A biomimetic delivery strategy for transforming growth factor beta (TGF-β) is described, in which TGF-β is presented in a latent form (the small latent complex, SLC), which is inactive until modified by the actions of the cells. In this work, SLC is tethered to a hyaluronic acid hydrogel scaffold to enhance in vitro chondrogenesis.
authors.affiliation: Department of Materials, Imperial College, London SW7 2AZ, UK.
authors.forename: Elsie S
authors.initials: ES
authors.lastname: Place
authors.forename: Rekha
authors.initials: R
authors.lastname: Nair
authors.forename: Helena N
authors.initials: HN
authors.lastname: Chia
authors.forename: Greg
authors.initials: G
authors.lastname: Szulgit
authors.forename: Erh-hsuin
authors.initials: EH
authors.lastname: Lim
authors.forename: Molly M
authors.initials: MM
authors.lastname: Stevens
mesh_terms: D000818:Animals; D002356:Cartilage / Q000166:cytology / Q000254:growth & development*; D002417:Cattle; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology* / Q000502:physiology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D020100:Hydrogels / Q000737:chemistry; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods; D054457:Tissue Scaffolds; D016212:Transforming Growth Factor beta / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D020100:Hydrogels; D016212:Transforming Growth Factor beta