title: Non-abortive effect of Adhatoda vasica spissum leaf extract by oral administration in rats.
abstract: The possible abortive effect of an extract of Adhatoda vasica leaf spissum, was studied in rats. The principal alkaloid detected in the extract was vasicine (0.85 ± 0.03%). The extract (325 mg/kg/day) was administered with a gastric cannula to a group of 5 pregnant females between day 1 and 9 of pregnancy. In another experiment 9 pregnant females received in the water 0.25 and 2.5% of Adhatoda vasica between day 1 and 9 of pregnancy. It was concluded that the administration of Adhatoda vasica did not produce abortion in any of the treated groups.
authors.affiliation: Swedish Herbal Institute, Gothenburg Sweden; Unidad de Reproducción y Desarollo, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: R
authors.initials: R
authors.lastname: Burgos
authors.forename: M
authors.initials: M
authors.lastname: Forcelledo
authors.forename: H
authors.initials: H
authors.lastname: Wagner
authors.forename: A
authors.initials: A
authors.lastname: Müller
authors.forename: J
authors.initials: J
authors.lastname: Hancke
authors.forename: G
authors.initials: G
authors.lastname: Wikman
authors.forename: H
authors.initials: H
authors.lastname: Croxatto