title: The impact of spinal anaesthesia for caesarean delivery on coagulation assessed by thromboelastography.
abstract: BACKGROUND
  Pregnancy and puerperium are associated with a hypercoagulable state. The aim of the study was to assess the impact of spinal anaesthesia on coagulation using thromboelastography in healthy term pregnant women undergoing elective caesarean delivery.
  
  
  METHODS
  Thromboelastography was performed on 60 women undergoing elective caesarean delivery under spinal anaesthesia. As spinal anaesthesia has different effects on upper and lower extremity vasculature, venous blood samples were collected from both hand and foot, before and one hour after spinal injection.
  
  
  RESULTS
  In the hand samples, R and K values decreased significantly from before to one hour after spinal injection (5.7±1.9 min versus 3.6±1.3 min, P<0.001 and 2.1±0.9 min versus 1.5±0.4 min, P<0.001, respectively). At the same times, significant increases in the alpha angle (58.6±9.1 degrees versus 65.6±7.5 degrees, P<0.001), MA (85.1±4.6 mm versus 87.0±3.8 mm, P<0.001) and CI (2.6±2.1 versus 4.9±1.5, P<0.001) were seen. No significant changes were found in thromboelastography parameters in samples collected from foot veins before and one hour after spinal injection, with the exception of the alpha angle (62.1±11.5 versus 66.5±8.8 degrees, P<0.012).
  
  
  CONCLUSIONS
  In women undergoing caesarean delivery under spinal anaesthesia, enhanced coagulation thromboelastography parameters were observed in blood collected from hand veins. No changes were detected in the majority of parameters collected from the foot. Spinal anaesthesia has different effects on coagulation parameters in the hand and foot in pregnant women undergoing caesarean delivery.
authors.affiliation: Department of Anaesthesiology, Aretaieio Hospital, Athens, Greece. fassoula@aretaieio.uoa.gr
authors.forename: A
authors.initials: A
authors.lastname: Fassoulaki
authors.forename: C
authors.initials: C
authors.lastname: Staikou
mesh_terms: D000328:Adult; D000577:Amides / Q000008:administration & dosage / Q000494:pharmacology; D000773:Anesthesia, Obstetrical / Q000379:methods*; D000775:Anesthesia, Spinal / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D002585:Cesarean Section; D017558:Elective Surgical Procedures / Q000379:methods; D005260:Female; D005528:Foot / Q000098:blood supply; D006225:Hand / Q000098:blood supply; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D011247:Pregnancy; D000077212:Ropivacaine; D013916:Thrombelastography / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine