title: Cardiopulmonary interactions in acute lung injury.
abstract: OBJECTIVE
  Through shared anatomy, pressures, and endothelial connections, the respiratory and cardiovascular systems affect each other in complex but clinically important ways.
  
  
  RESULTS
  Lung injury has clinically important circulatory effects, especially with regards to right ventricular function. Mechanical ventilation and PEEP produce a host of circulatory consequences, some beneficial, some life-threatening. At the same time, circulatory impairments and treatments can magnify the impact of lung failure.
  
  
  CONCLUSIONS
  Cardiopulmonary interactions underpin current views of fluid management and mechanical ventilation. Understanding cardiopulmonary interactions and their physiological basis has direct clinical relevance.
authors.affiliation: Division of Pulmonary Diseases, Critical Care, and Occupational Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA. Gregory-a-schmidt@uiowa.edu
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Schmidt
mesh_terms: D055371:Acute Lung Injury / Q000503:physiopathology / Q000628:therapy*; D016887:Cardiopulmonary Resuscitation / Q000379:methods; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008297:Male; D011175:Positive-Pressure Respiration / Q000009:adverse effects / Q000379:methods*; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods*; D012131:Respiratory Insufficiency / Q000503:physiopathology / Q000628:therapy*; D016278:Ventricular Function, Right