title: [Deacetylase SIRT1 and vascular endothelial function].
abstract: Silent information regulator factor 2-related enzyme 1 (Sirtuins 1, SIRT1) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, which can deacetylate histone and non-histone proteins and other transcription factors, and is involved in the regulation of many physiological functions, including gene transcription, energy metabolism, cell senescence and oxidative stress. Recent studies show that through adjusting the activity of endothelial nitric oxide syntheses (eNOS), p53, forkhead box class O (FOXO) and nuclear factor kappa B (NF-kappaB), SIRT1 can protect the functions of vascular endothelia and nerves in a variety of pathological conditions. Therefore, SIRT1 may be used as a potential therapeutic target of these diseases, particularly erectile dysfunction, which are associated with endothelial dysfunction.
authors.affiliation: Department of Urology, Drum Tower Hospital Affiliated to Nanjing University School of Medicine, Nanjing, Jiangsu 210008, China.
authors.forename: Zan
authors.initials: Z
authors.lastname: Wan
authors.forename: Wen
authors.initials: W
authors.lastname: Yu
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
authors.forename: Yu-Tian
authors.initials: YT
authors.lastname: Dai
mesh_terms: D004730:Endothelium, Vascular / Q000502:physiology*; D007172:Erectile Dysfunction; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D008297:Male; D009243:NAD / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D018384:Oxidative Stress; D056564:Sirtuin 1 / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D016328:NF-kappa B; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D009243:NAD; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; D056564:Sirtuin 1