title: Circulating interleukin 6 and soluble forms of its receptors in relation to resting energy expenditure in women with anorexia nervosa.
abstract: BACKGROUND
  Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL-6) may play a role in appetite, energy expenditure and body weight control. IL-6 acts through binding with membrane receptor (IL-6R) and activates glycoprotein 130 (gp130) signalling. Both IL-6R and gp130 are present in the blood in the soluble forms (sIL-6R and sgp130 respectively). sIL-6R sensitizes cells towards IL-6, whereas sgp130 inhibits gp130 signalling.
  
  
  OBJECTIVE
  To estimate circulating IL-6/sIL-6R/sgp130 system and its relationships with body weight and resting energy expenditure (REE) in AN women.
  
  
  METHODS
  We examined 19 women with AN and 27 healthy normal-weight female controls.
  
  
  METHODS
  Indirect calorimetry and the measurement of serum IL-6, sIL-6R and sgp130 concentrations were performed in all the subjects.
  
  
  RESULTS
  REE was decreased in AN women (P < 0·001). Serum IL-6 was higher in AN women in comparison with control group (P = 0·005). Serum sIL-6R was lower (P = 0·009) and serum sgp130 was higher (P = 0·004) in AN women in comparison with controls. IL-6 and sIL-6R were related to REE in the entire study population (r = -0·54, P < 0·001 and r = 0·48, P = 0·001 respectively) and in AN group (r = -0·54, P = 0·024 and r = 0·60, P = 0·011 respectively).
  
  
  CONCLUSIONS
  Increased IL-6 in AN seems to be compensated by the changes in sIL-6R and sgp130, which are directed towards inhibition of IL-6 action. The balance between these factors might play a role in the regulation of energy expenditure in AN.
authors.affiliation: Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok.
authors.forename: Monika
authors.initials: M
authors.lastname: Karczewska-Kupczewska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Adamska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Nikołajuk
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Otziomek
authors.forename: Maria
authors.initials: M
authors.lastname: Górska
authors.forename: Irina
authors.initials: I
authors.lastname: Kowalska
authors.forename: Marek
authors.initials: M
authors.lastname: Strączkowski
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000378:metabolism*; D001481:Basal Metabolism; D016022:Case-Control Studies; D050822:Cytokine Receptor gp130 / Q000097:blood*; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D019947:Receptors, Interleukin-6 / Q000097:blood*; D015398:Signal Transduction; D012995:Solubility; D055815:Young Adult
chemical_list: C508600:IL6 protein, human; C508603:IL6R protein, human; D015850:Interleukin-6; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130