title: The new HPLC methodology for the chiral separation of tamsulosin enantiomers on amylose tris(3,5-dimethylphenylcarbamate) stationary phase.
abstract: New chromatographic method for the enantioseparation of (R,S)-tamsulosin and the determination of (R)- and (S)-tamsulosin was developed with the aid of amylose tris(3,5-dimethylphenylcarbamate) stationary phase. The method was compared to the known procedure for tamsulosin enantioseparation on cellulose tris(3,5-dimethylphenyl carbamate). Careful validation of both methods allowed to prove advantages of the new procedure: significantly better resolution as well as twice better sensitivity. The method was applied to quantification of (R)- and (S)-tamsulosin contents in prolonged release Apo-Tamis 0.4 mg hard capsules (Apotex Europe B.V) and Omnic Ocas 0.4 mg coated tablets (Astellas).
authors.affiliation: National Medicines Institute, 30/34 Chełmska St, 00-725 Warsaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kantor-Boruta
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Lisowska-Kuźmicz
authors.forename: Anna
authors.initials: A
authors.lastname: Jończyk
authors.forename: Joanna
authors.initials: J
authors.lastname: Siedlecka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Ocios-Bębenek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Jarończyk
authors.forename: Aleksander P
authors.initials: AP
authors.lastname: Mazurek
authors.forename: Hanna
authors.initials: H
authors.lastname: Ksycińska
authors.forename: Zdzisław
authors.initials: Z
authors.lastname: Chilmonczyk
authors.forename: Maciej
authors.initials: M
authors.lastname: Jarosz
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000032:analysis* / Q000737:chemistry; D000688:Amylose / Q000031:analogs & derivatives* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D048448:Phenylcarbamates / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000032:analysis* / Q000737:chemistry; D000077409:Tamsulosin
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D048448:Phenylcarbamates; D013449:Sulfonamides; C080033:Chiralpak AD; D000688:Amylose; D000077409:Tamsulosin