title: High versus low radioiodine activity in patients with differentiated thyroid cancer: a meta-analysis.
abstract: BACKGROUND
  The purpose of the meta-analysis was to estimate the effectiveness and toxicity of low activity radioiodine ablation versus high activity in patients with differentiated thyroid cancer (DTC).
  
  
  METHODS
  A systematic review and meta-analysis was performed by including all randomized trials of low activity versus high activity radioiodine ablation after thyroidectomy. Standard meta-analytic procedures were used to analyze the study outcomes.
  
  
  RESULTS
  Ten trials were considered eligible and were further analyzed. The pooled risk ratio (RR) of having a successful ablation for an activity of 1100 MBq versus 3700 MBq (seven trials, 1772 patients) was 0.94 (95% CI 0.85-1.04, p-value = 0.21). The RR for successful ablation when only thyroid hormone withdrawal was used (five trials, 1116 patients) was 0.87 (95% CI 0.72-1.06, p-value = 0.17) and it was comparable to RR when only recombinant-human TSH (rec-hTSH) (two trials, 812 patients) was used (1.00, 95% CI 0.93-1.07, p-value = 0.92). Salivary dysfunction, nausea, and neck pain were significantly more frequent among patients with higher dose for ablation.
  
  
  CONCLUSIONS
  Our meta-analysis provides some evidence from randomized trials that a lower activity of radioiodine ablation is as effective as higher dose after surgery in patients with DTC with lower toxicity.
authors.affiliation: Department of Oncology, Mälarsjukhuset, Eskilstuna, Sweden. Valachis@hotmail.com
authors.forename: Antonis
authors.initials: A
authors.lastname: Valachis
authors.forename: Andreas
authors.initials: A
authors.lastname: Nearchou
mesh_terms: D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D011829:Radiation Dosage; D016032:Randomized Controlled Trials as Topic; D013964:Thyroid Neoplasms / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes