title: Effects of an exercise and hypocaloric healthy eating program on biomarkers associated with long-term prognosis after early-stage breast cancer: a randomized controlled trial.
abstract: Excess body weight at diagnosis and weight gain after breast cancer are associated with poorer long-term prognosis. This study investigated the effects of a lifestyle intervention on body weight and other health outcomes influencing long-term prognosis in overweight women (BMI > 25.0 kg/m(2)) recovering from early-stage (stage I-III) breast cancer. A total of 90 women treated 3-18 months previously were randomly allocated to a 6-month exercise and hypocaloric healthy eating program (n = 47, aged 55.6 ± 10.2 year) or control group (n = 43, aged 55.9 ± 8.9 year). Women in the intervention group received three supervised exercise sessions per week and individualized dietary advice, supplemented by weekly nutrition seminars. Body weight, waist circumference, waist/hip ratio [WHR], cardiorespiratory fitness, blood biomarkers associated with breast cancer recurrence and cardiovascular disease risk, and quality of life (FACT-B) were assessed at baseline and 6 months. Three-day diet diaries were used to assess macronutrient and energy intakes. A moderate reduction in body weight in the intervention group (median difference from baseline of -1.09 kg; IQR -0.15 to -2.90 kg; p = 0.07) was accompanied by significant reductions in waist circumference (p < 0.001), WHR (p = 0.005), total (p = 0.021) and saturated fat (p = 0.006) intakes, leptin (p = 0.005), total cholesterol (p = 0.046), and resting diastolic blood pressure (p = 0.03). Cardiopulmonary fitness (p < 0.001) and FACT-B quality of life (p = 0.004) also showed significant improvements in the intervention group. These findings suggest that an individualized exercise and a hypocaloric healthy eating program can positively impact upon health outcomes influencing long-term prognosis in overweight women recovering from early-stage breast cancer.
authors.affiliation: School of Health and Related Research, University of Sheffield, Sheffield, UK.
authors.forename: E
authors.initials: E
authors.lastname: Scott
authors.forename: A J
authors.initials: AJ
authors.lastname: Daley
authors.forename: H
authors.initials: H
authors.lastname: Doll
authors.forename: N
authors.initials: N
authors.lastname: Woodroofe
authors.forename: R E
authors.initials: RE
authors.lastname: Coleman
authors.forename: N
authors.initials: N
authors.lastname: Mutrie
authors.forename: H
authors.initials: H
authors.lastname: Crank
authors.forename: H J
authors.initials: HJ
authors.lastname: Powers
authors.forename: J M
authors.initials: JM
authors.lastname: Saxton
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood / Q000378:metabolism; D001943:Breast Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D031204:Caloric Restriction; D002277:Carcinoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D006262:Health; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D050177:Overweight / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis; D017741:Survivors / Q000706:statistics & numerical data; D061217:Weight Reduction Programs / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor