title: Information processing in network architecture of genome controlled signal transduction circuit. A proposed theoretical explanation.
abstract: In this paper, Shannon information theory has been applied to elaborate cell signaling. It is proposed that in the cellular network architecture, four components viz. source (DNA), transmitter (mRNA), receiver (protein) and destination (another protein) are involved. The message transmits from source (DNA) to transmitter (mRNA) and then passes through a noisy channel reaching finally the receiver (protein). The protein synthesis process is here considered as the noisy channel. Ultimately, signal is transmitted from receiver to destination (another protein). The genome network architecture elements were compared with genetic alphabet L = {A, C, G, T} with a biophysical model based on the popular Shannon information theory. This study found the channel capacity as maximum for zero error (sigma = 0) and at this condition, transition matrix becomes a unit matrix with rank 4. The transition matrix will be erroneous and finally at sigma = 1 channel capacity will be localized maxima with a value of 0.415 due to the increased value at sigma. On the other hand, minima exists at sigma = 0.75, where all transition probabilities become 0.25 and uncertainty will be maximum resulting in channel capacity with the minima value of zero.
authors.affiliation: Medical Biotechnology, School of Bioscience and Technology, VIT University, Vellore, India.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
authors.forename: Bimal Kumar
authors.initials: BK
authors.lastname: Sarkar
authors.forename: Pratiksha
authors.initials: P
authors.lastname: Patel
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Agoramoorthy
mesh_terms: D016678:Genome / Q000502:physiology*; D007257:Information Theory; D008962:Models, Theoretical; D015398:Signal Transduction / Q000502:physiology*