title: Risk factors for rebleeding of aneurysmal subarachnoid hemorrhage based on the analysis of on-admission information.
abstract: OBJECTIVE
  To provide a quick evaluation of rebleeding risk based on the on-admission patient information and to guide the management of patients for better outcome.
  
  
  METHODS
  A retrospective review of 630 consecutive cases of subarachnoid hemorrhage (SAH) at a major medical center was conducted, of which 458 were included for analysis. Sixty three cases of in-hospital pre-intervention rebleeding were identified. Chi-square or Mann-Whitney tests were used to screen for possible risk factors and values of the associated risk factors were assessed by logistic multivariate regression.
  
  
  RESULTS
  The identified risk factors were: short time interval between the first attack and hospitalization, gender (males were more susceptible), poor Hunt-Hess grade (III~V), high systolic pressure ( > 140 mmHg), intracerebral or intraventricular hematoma, high level of serum glucose ( > 6.32 mmol/L) and high white blood cell count ( > 12 x 10^9/L). Use of antifibrinolysis medication did not differ between groups. Subgroup analysis showed that posterior circulation aneurysms had a significantly higher rebleeding rate. Logistic regression analysis showed that intracerebral or intraventricular hematoma (p=0.010, OR=1.478) and blood glucose level above 6.32 mmol/L (p=0.011, OR=2.126) were independent risk factors.
  
  
  CONCLUSIONS
  We found a particularly high risk of rebleeding in patients with intracerebral or intraventricular hematoma or relatively high serum glucose level on admission. Posterior circulation aneurysms rebleed seemed more prominently manifested. An earlier and more aggressive intervention may be applied to patients at high risk.
authors.affiliation: West China Hospital, Sichuan University, Department of Neurosurgery, Chengdu, Sichuan Province, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Cong
authors.forename: Zhao
authors.initials: Z
authors.lastname: Zhongxin
authors.forename: Li
authors.initials: L
authors.lastname: Tiangui
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: He
authors.initials: H
authors.lastname: Min
authors.forename: You
authors.initials: Y
authors.lastname: Chao
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006406:Hematoma / Q000150:complications*; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D055502:Secondary Prevention; D012680:Sensitivity and Specificity; D013345:Subarachnoid Hemorrhage / Q000209:etiology* / Q000503:physiopathology; D016896:Treatment Outcome