title: PEI conjugated gold nanoparticles: efficient gene carriers with visible fluorescence.
abstract: Low molecular weight polyethyleneimines were conjugated onto gold nanoparticles to form Au-PEI conjugates. Au-PEI is the first reported gene carrier which has both high transfection efficiency and strong fluorescence. Au-PEI showed higher transfection efficiency and it can be used for bioimaging because it can be detected by confocal laser scanning microscopy and in vivo bioimaging system.
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Huayu
authors.initials: H
authors.lastname: Tian
authors.forename: Zhaopei
authors.initials: Z
authors.lastname: Guo
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.forename: Jialiang
authors.initials: J
authors.lastname: Xia
authors.forename: Xuan
authors.initials: X
authors.lastname: Dong
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D016466:CHO Cells; D019556:COS Cells; D002522:Chlorocebus aethiops; D006224:Cricetinae; D003412:Cricetulus; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007097:Imines / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008856:Microscopy, Fluorescence / Q000379:methods*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011095:Polyethylenes / Q000737:chemistry*; D014162:Transfection / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes; D007097:Imines; D053769:Nanocapsules; D011095:Polyethylenes; C505405:poly(ethylene imine); D006046:Gold