title: Effects of exercise intervention on vascular risk factors in older adults with mild cognitive impairment: a randomized controlled trial.
abstract: OBJECTIVE
  The purpose of this study is to clarify the effects of exercise intervention on vascular risk factors in older adults with mild cognitive impairment (MCI).
  
  
  METHODS
  Community-dwelling older adults who met the definition of MCI using the Petersen criteria (n = 100; mean age = 75.3 years) were randomly allocated to the exercise (n = 50) or education control group (n = 50). Participants in the exercise group exercised under the supervision of physiotherapists for 90 min/day, 2 days/week, 80 times for 12 months. Anthropometric profiles, blood markers, blood pressure, and physical fitness (the 6-min walking test) were measured. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and TC/HDL-C risk ratio measurements were taken from blood samples.
  
  
  RESULTS
  The exercise group showed significantly reduced TC and TC/HDL-C risk ratio after training compared with baseline levels (p < 0.001, p = 0.004). However, no significant reduction was found for the control group (p = 0.09, p = 0.09). Physical fitness also significantly improved after exercise intervention compared with the control group (p < 0.0001).
  
  
  CONCLUSIONS
  Exercise intervention was associated with positive changes in important vascular risk factors related to cognitive decline and vascular disease in older adults with MCI.
authors.affiliation: Section for Health Promotion, Center for Gerontology and Social Science, Obu, Japan ; Japan Society for the Promotion of Science, Tokyo, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Uemura
authors.forename: Takehiko
authors.initials: T
authors.lastname: Doi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimada
authors.forename: Hyuma
authors.initials: H
authors.lastname: Makizako
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshida
authors.forename: Kota
authors.initials: K
authors.lastname: Tsutsumimoto
authors.forename: Yuya
authors.initials: Y
authors.lastname: Anan
authors.forename: Takao
authors.initials: T
authors.lastname: Suzuki