title: A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome.
abstract: OBJECTIVE
  Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) is a rare disorder that mimics both common obesity and genetic obesity syndromes along with several endocrine disorders during early childhood. We aim to present the clinical features, laboratory and imaging results, and treatment outcomes of a patient with ROHHAD syndrome.
  
  
  METHODS
  In this case report, we describe a 26-month-old boy who was admitted to our emergency department with dyspnea and cyanosis and was suspected to have ROHHAD syndrome due to his rapid-onset obesity and alveolar hypoventilation.
  
  
  RESULTS
  A thoracal and abdominal magnetic resonance imaging was performed to demonstrate a possible accompanying neural crest tumor and it provided a yet asymptomatic retroperitoneal ganglioneuroblastoma. Based on these findings, the patient was diagnosed as ROHHADNET syndrome.
  
  
  CONCLUSIONS
  Because of the high prevalence of cardiorespiratory arrest and probability of accompanying tumors, early recognition of ROHHAD syndrome is important. To prevent presumptive mortality and morbidity, ROHHAD syndrome should be considered in all cases of rapid and early-onset obesity associated with hypothalamic-pituitary endocrine dysfunctions.
authors.affiliation: Pediatric Endocrinology Department, Eylül University Faculty of Medicine, Izmir, Turkey. ayhanabaci@gmail.com
authors.forename: Ayhan
authors.initials: A
authors.lastname: Abaci
authors.forename: Gonul
authors.initials: G
authors.lastname: Catli
authors.forename: Erhan
authors.initials: E
authors.lastname: Bayram
authors.forename: Tolga
authors.initials: T
authors.lastname: Koroglu
authors.forename: Hatice Nur
authors.initials: HN
authors.lastname: Olgun
authors.forename: Kamer
authors.initials: K
authors.lastname: Mutafoglu
authors.forename: Ayse Semra
authors.initials: AS
authors.lastname: Hiz
authors.forename: Handan
authors.initials: H
authors.lastname: Cakmakci
authors.forename: Ece
authors.initials: E
authors.lastname: Bober
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis*; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis*; D002675:Child, Preschool; D018305:Ganglioneuroblastoma / Q000175:diagnosis*; D006801:Humans; D007027:Hypothalamic Diseases / Q000175:diagnosis*; D007040:Hypoventilation / Q000175:diagnosis*; D008297:Male; D009765:Obesity / Q000175:diagnosis*; D013577:Syndrome