title: No carcinogenicity of ethyl tertiary-butyl ether by 2-year oral administration in rats.
abstract: The carcinogenicity of ethyl tertiary-butyl ether (ETBE) was examined by oral administration using F344/DuCrlCrlj rats. Groups of 50 male and 50 female rats were given drinking water containing ETBE at doses of 0, 625, 2,500 or 10,000 ppm (w/w) for 104 weeks. No significant increase in the incidence of tumors was detected in any organ of either sex. Rat-specific non-neoplastic lesions were observed in the kidney: An increase in the severity of chronic progressive nephropathy was observed in the male and female 10,000 ppm groups, and increased incidences of urothelial hyperplasia of the pelvis and mineral deposition in the renal papilla were observed in the male 2,500 and 10,000 ppm groups. Besides these lesions, no treatment-related histopathological changes were observed in any organ or tissue in either sex. Thus, the present study demonstrated that a two year administration ETBE in the drinking water did not exert any carcinogenic effects in either male or female rats.
authors.affiliation: Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Kanagawa, Japan. m-suzuki@jisha.or.jp
authors.forename: Masaaki
authors.initials: M
authors.lastname: Suzuki
authors.forename: Kazunori
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kano
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Aiso
authors.forename: Kasuke
authors.initials: K
authors.lastname: Nagano
authors.forename: Shoji
authors.initials: S
authors.lastname: Fukushima
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015197:Carcinogenicity Tests; D004305:Dose-Response Relationship, Drug; D005019:Ethyl Ethers / Q000008:administration & dosage* / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
chemical_list: D005019:Ethyl Ethers; C098546:ethyl tert-butyl ether