title: Mobilization and collection of peripheral blood stem cells in healthy donors: risks, adverse events and follow-up.
abstract: Allogeneic haematopoietic stem cell transplantation is the choice treatment for many haematological malignancies. Granulocyte-colony-stimulating factor (G-CSF) has been widely used to mobilize stem cells into the peripheral blood from healthy siblings or volunteer unrelated donors. To a large extent, the use of mobilized peripheral blood haematopoietic stem cells has replaced marrow-derived stem cells as the preferred source of donor haematopoietic stem cells. Clinicians have been aware since the first clinical use, that administration of G-CSF, even in a single short course, could possibly be a risk for healthy donors either in short-term or as a delayed effect. The immediate side effects of G-CSF have been established for a long time, most of them are frequent but transient, self-limited and without long-term consequences. Questions have been raised about potential long-term adverse effects such as an elevated risk of haematological malignancies after G-CSF administration. More long-term safety data from registries are needed to adequately evaluate such a relationship. Our objective in this article is to provide an in-depth review of reported adverse events associated with the use of G-CSF in healthy donors and to focus attention on unanswered questions related to their long-term follow-up.
authors.affiliation: Laboratoire de génétique moléculaire et d'histocompatibilité, pôle de pathologie biologie, CHRU Morvan, bâtiment 5bis, RDC, 2, avenue Foch, 29609 Brest cedex, France. virginie.moalic@chu-brest.fr
authors.forename: V
authors.initials: V
authors.lastname: Moalic
mesh_terms: D000818:Animals; D001782:Blood Donors; D001800:Blood Specimen Collection / Q000009:adverse effects* / Q000379:methods / Q000706:statistics & numerical data; D005500:Follow-Up Studies; D006262:Health; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects* / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D007937:Leukapheresis / Q000379:methods; D036102:Peripheral Blood Stem Cell Transplantation; D012306:Risk