title: IGEMS: the consortium on Interplay of Genes and Environment across Multiple Studies.
abstract: The Interplay of Genes and Environment across Multiple Studies (IGEMS) group is a consortium of eight longitudinal twin studies established to explore the nature of social context effects and gene-environment interplay in late-life functioning. The resulting analysis of the combined data from over 17,500 participants aged 25-102 at baseline (including nearly 2,600 monogygotic and 4,300 dizygotic twin pairs and over 1,700 family members) aims to understand why early life adversity, and social factors such as isolation and loneliness, are associated with diverse outcomes including mortality, physical functioning (health, functional ability), and psychological functioning (well-being, cognition), particularly in later life.
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Nancy.Pedersen@ki.se
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Pedersen
authors.forename: Kaare
authors.initials: K
authors.lastname: Christensen
authors.forename: Anna K
authors.initials: AK
authors.lastname: Dahl
authors.forename: Deborah
authors.initials: D
authors.lastname: Finkel
authors.forename: Carol E
authors.initials: CE
authors.lastname: Franz
authors.forename: Margaret
authors.initials: M
authors.lastname: Gatz
authors.forename: Briana N
authors.initials: BN
authors.lastname: Horwitz
authors.forename: Boo
authors.initials: B
authors.lastname: Johansson
authors.forename: Wendy
authors.initials: W
authors.lastname: Johnson
authors.forename: William S
authors.initials: WS
authors.lastname: Kremen
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Lyons
authors.forename: Bo
authors.initials: B
authors.lastname: Malmberg
authors.forename: Matt
authors.initials: M
authors.lastname: McGue
authors.forename: Jenae M
authors.initials: JM
authors.lastname: Neiderhiser
authors.forename: Inge
authors.initials: I
authors.lastname: Petersen
authors.forename: Chandra A
authors.initials: CA
authors.lastname: Reynolds
mesh_terms: D000328:Adult; D000368:Aged; D003072:Cognition Disorders / Q000235:genetics* / Q000523:psychology; D004200:Diseases in Twins / Q000235:genetics* / Q000523:psychology; D005190:Family / Q000523:psychology; D005260:Female; D059647:Gene-Environment Interaction; D005824:Genetics, Behavioral; D006304:Health Status; D006801:Humans; D007390:International Agencies; D008132:Loneliness / Q000523:psychology; D008137:Longitudinal Studies; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D012042:Registries; D012931:Social Environment; D014429:Twins, Dizygotic / Q000235:genetics* / Q000523:psychology; D014430:Twins, Monozygotic / Q000235:genetics* / Q000523:psychology; D055815:Young Adult