title: Titivated for destruction: the methyl degron.
abstract: In this issue, Lee et al. (2012) demonstrate that the degradation of RORα is regulated by the EZH2-DCAF1/DDB1/CUL4 proteasome axis, thus identifying protein methylation as a posttranslational modification that can orchestrate protein destruction through a motif termed the "methyl degron."
authors.affiliation: The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, P.O. Box 389, Smithville, TX 78957, USA.
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Yang
authors.forename: Mark T
authors.initials: MT
authors.lastname: Bedford