title: Switch from selegiline to rasagiline is beneficial in patients with Parkinson's disease.
abstract: The objective of this study is to demonstrate that application of rasagiline instead of selegiline with concomitant determination of L-amphetamine and L-methamphetamine in plasma is safe and well tolerated and influences sleep, mood, and motor behavior in patients with Parkinson's disease on a stable drug therapy. 30 patients, who took 7.5 mg selegiline daily for at least 3 months, were switched to 1 mg rasagiline. Then they were followed over an interval of 4 months. The remaining drug therapy remained stable. This changeover was safe and well tolerated. L-Amphetamine and L-methamphetamine only appeared during selegiline treatment. Motor behavior, motor complications, mood and sleep improved during rasagiline administration. Amphetamine-like derivatives of selegiline could contribute to sleep disturbances, which may be involved in worsening of mood. Motor behavior and motor complications probably became better due to the additional glutamate receptor antagonizing properties of rasagiline in this open label study.
authors.affiliation: Department of Neurology, St. Joseph-Hospital, Gartenstr. 1, 13088 Berlin, Germany. th.mueller@alexius.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Müller
authors.forename: Josef A
authors.initials: JA
authors.lastname: Hoffmann
authors.forename: Walter
authors.initials: W
authors.lastname: Dimpfel
authors.forename: Christian
authors.initials: C
authors.lastname: Oehlwein
mesh_terms: D000368:Aged; D000661:Amphetamine / Q000097:blood; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D057915:Drug Substitution / Q000379:methods*; D005260:Female; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D008297:Male; D008694:Methamphetamine / Q000097:blood; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents; D010300:Parkinson Disease / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D012642:Selegiline / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D000978:Antiparkinson Agents; D007189:Indans; D018696:Neuroprotective Agents; C031967:rasagiline; D012642:Selegiline; D008694:Methamphetamine; D000661:Amphetamine