title: The Baboon (Papio spp.) as a model of human Ebola virus infection.
abstract: Baboons are susceptible to natural Ebola virus (EBOV) infection and share 96% genetic homology with humans. Despite these characteristics, baboons have rarely been utilized as experimental models of human EBOV infection to evaluate the efficacy of prophylactics and therapeutics in the United States. This review will summarize what is known about the pathogenesis of EBOV infection in baboons compared to EBOV infection in humans and other Old World nonhuman primates. In addition, we will discuss how closely the baboon model recapitulates human EBOV infection. We will also review some of the housing requirements and behavioral attributes of baboons compared to other Old World nonhuman primates. Due to the lack of data available on the pathogenesis of Marburg virus (MARV) infection in baboons, discussion of the pathogenesis of MARV infection in baboons will be limited.
authors.affiliation: Integrated Research Facility, Division of Clinical Research, NIAID, NIH, Frederick, MD, USA. perrydl@niaid.nih.gov
authors.forename: Donna L
authors.initials: DL
authors.lastname: Perry
authors.forename: Laura
authors.initials: L
authors.lastname: Bollinger
authors.forename: Gary L
authors.initials: GL
authors.lastname: White
mesh_terms: D000818:Animals; D001483:Base Sequence; D001779:Blood Coagulation Factors / Q000378:metabolism; D004195:Disease Models, Animal; D029043:Ebolavirus / Q000472:pathogenicity*; D005337:Fibrin / Q000378:metabolism; D019142:Hemorrhagic Fever, Ebola / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D006801:Humans; D008206:Lymphatic Diseases / Q000473:pathology / Q000821:virology; D008379:Marburg Virus Disease / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D029024:Marburgvirus / Q000472:pathogenicity; D009336:Necrosis / Q000473:pathology / Q000821:virology; D010215:Papio / Q000821:virology*; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D013921:Thrombocytopenia / Q000473:pathology / Q000821:virology
chemical_list: D001779:Blood Coagulation Factors; D005337:Fibrin