title: Clinical staging of semantic dementia in an FDG-PET study using FTLD-CDR.
abstract: BACKGROUND
  The frontotemporal lobar degeneration-specific clinical dementia rating (FTLD-CDR), which was recently developed to measure frontotemporal dementia (FTD) severity, includes 2 items that assess language and behavior in addition to the 6 items of the conventional CDR.
  
  
  METHODS
  To investigate which of the 3 ratings, i.e. the global score of the CDR (GCDR), the behavioral domain score of the FTLD-CDR (BCDR), or the language domain score of the FTLD-CDR (LCDR), is most suitable for monitoring the progression of semantic dementia (SD), the number of hypometabolic voxels was calculated by comparing 28 SD patients in each stage of the 3 ratings with 63 age/sex-matched controls using voxel-based statistical parametric mapping.
  
  
  RESULTS
  The hypometabolic areas increased as a function of the LCDR score in SD patients. However, hypometabolic areas associated with the GCDR did not increase gradually as the stage increased. Furthermore, those associated with the BCDR showed the reverse pattern.
  
  
  CONCLUSIONS
  Our findings suggest that the severity and patterning of glucose hypometabolism measured by the LCDR correspond well with the natural course of SD reported in previous clinical and neuroimaging studies, whereas the BCDR and GCDR did not reflect disease progression in SD.
authors.affiliation: Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Seoul, Korea.
authors.forename: Eun-Joo
authors.initials: EJ
authors.lastname: Kim
authors.forename: Byeong C
authors.initials: BC
authors.lastname: Kim
authors.forename: Seong-Jang
authors.initials: SJ
authors.lastname: Kim
authors.forename: Dae Soo
authors.initials: DS
authors.lastname: Jung
authors.forename: Ji-Soo
authors.initials: JS
authors.lastname: Sin
authors.forename: Yeo-Ju
authors.initials: YJ
authors.lastname: Yoon
authors.forename: Juhee
authors.initials: J
authors.lastname: Chin
authors.forename: Kyung-Han
authors.initials: KH
authors.lastname: Lee
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
mesh_terms: D017668:Age of Onset; D000368:Aged; D001923:Brain Chemistry; D001931:Brain Mapping; D003704:Dementia / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000523:psychology*; D018450:Disease Progression; D005260:Female; D019788:Fluorodeoxyglucose F18; D057174:Frontotemporal Lobar Degeneration / Q000000981:diagnostic imaging* / Q000523:psychology*; D007839:Functional Laterality / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012044:Regression Analysis
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose