title: Further investigation of the Mediterranean sponge Axinella polypoides: isolation of a new cyclonucleoside and a new betaine.
abstract: An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The analysis also provided evidence that the sponge does not elaborate pyrrole-imidazole alkaloids (PIAs) but, interestingly, it was shown to contain two already known cyclodipeptides, compounds 9 (verpacamide A) and 10.
authors.affiliation: The NeaNat Group, Department of Chemistry of Natural Products, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, Italy. mlmenna@unina.it
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Menna
authors.forename: Anna
authors.initials: A
authors.lastname: Aiello
authors.forename: Filomena
authors.initials: F
authors.lastname: D'Aniello
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fattorusso
authors.forename: Concetta
authors.initials: C
authors.lastname: Imperatore
authors.forename: Paolo
authors.initials: P
authors.lastname: Luciano
authors.forename: Rocco
authors.initials: R
authors.lastname: Vitalone
mesh_terms: D000818:Animals; D047089:Axinella / Q000737:chemistry*; D001622:Betaine / Q000737:chemistry* / Q000302:isolation & purification; D008522:Mediterranean Sea; D009705:Nucleosides / Q000737:chemistry* / Q000302:isolation & purification; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification; D013057:Spectrum Analysis
chemical_list: D009705:Nucleosides; D010456:Peptides, Cyclic; D001622:Betaine