title: [The effect of H. pylori eradication against prevention of gastric cancer].
abstract: H. pylori is a definite carcinogen of gastric cancer. Animal studies have revealed that primary prevention of gastric cancer by H. pylori eradication is more effective as the duration between H. pylori infection and H. pylori eradication is decreased. In human, the cohort studies showed H. pylori eradication reduced the incidence of gastric cancer in the case with high incidence rate of gastric cancer. In a multi-center, randomized controlled study, H. pylori eradication prevented the incidence of metachronous cancer after endoscopic resection of early gastric cancer. Meta-analysis of RCT suggested that the incidence of gastric cancer was suppressed by H. pylori eradication. The strategy for elimination of gastric cancer in Japan should consist of H. pylori eradication as primary prevention and surveillance of gastric cancer using endoscopy as secondary prevention.
authors.affiliation: Department of Endoscopy, Hokkaido University Hospital.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Mabe
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Kato
authors.forename: Shoko
authors.initials: S
authors.lastname: Ono
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
authors.forename: Naoya
authors.initials: N
authors.lastname: Sakamoto
mesh_terms: D000818:Animals; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D015201:Meta-Analysis as Topic; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D013274:Stomach Neoplasms / Q000382:microbiology / Q000517:prevention & control*