title: Refined flicker photometry technique to measure ocular lens density.
abstract: Many physiological and pathological conditions are associated with a change in the crystalline lens transmittance. Estimates of lens opacification, however, generally rely on subjective rather than objective measures in clinical practice. The goal of our study was to develop an improved psychophysical heterochromatic flicker photometry technique combined with existing mathematical models to evaluate the spectral transmittance of the human ocular media noninvasively. Our results show that it is possible to accurately estimate ocular media density in vivo in humans. Potential applications of our approach include basic research and clinical settings on visual and nonimage-forming visual systems.
authors.affiliation: Stem Cell and Brain Research Institute, INSERM U846, 18 avenue Doyen Lepine, 69500 Bron, France. petteri.teikari@gmail.com
authors.forename: Petteri
authors.initials: P
authors.lastname: Teikari
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Najjar
authors.forename: Kenneth
authors.initials: K
authors.lastname: Knoblauch
authors.forename: Dominique
authors.initials: D
authors.lastname: Dumortier
authors.forename: Pierre-Loïc
authors.initials: PL
authors.lastname: Cornut
authors.forename: Philippe
authors.initials: P
authors.lastname: Denis
authors.forename: Howard M
authors.initials: HM
authors.lastname: Cooper
authors.forename: Claude
authors.initials: C
authors.lastname: Gronfier
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010783:Photometry / Q000295:instrumentation / Q000379:methods*; D014796:Visual Perception / Q000502:physiology