title: Thinned-skull cortical window technique for in vivo optical coherence tomography imaging.
abstract: Optical coherence tomography (OCT) is a biomedical imaging technique with high spatial-temporal resolution. With its minimally invasive approach OCT has been used extensively in ophthalmology, dermatology, and gastroenterology. Using a thinned-skull cortical window (TSCW), we employ spectral-domain OCT (SD-OCT) modality as a tool to image the cortex in vivo. Commonly, an opened-skull has been used for neuro-imaging as it provides more versatility, however, a TSCW approach is less invasive and is an effective mean for long term imaging in neuropathology studies. Here, we present a method of creating a TSCW in a mouse model for in vivo OCT imaging of the cerebral cortex.
authors.affiliation: Division of Biomedical Sciences, University of California, Riverside, USA.
authors.forename: Jenny I
authors.initials: JI
authors.lastname: Szu
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Eberle
authors.forename: Carissa L
authors.initials: CL
authors.lastname: Reynolds
authors.forename: Mike S
authors.initials: MS
authors.lastname: Hsu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Christian M
authors.initials: CM
authors.lastname: Oh
authors.forename: M Shahidul
authors.initials: MS
authors.lastname: Islam
authors.forename: B Hyle
authors.initials: BH
authors.lastname: Park
authors.forename: Devin K
authors.initials: DK
authors.lastname: Binder
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D005260:Female; D007091:Image Processing, Computer-Assisted / Q000379:methods; D051379:Mice; D012886:Skull / Q000601:surgery*; D041623:Tomography, Optical Coherence / Q000379:methods*