title: Rational molecular design of complementary self-assembling peptide hydrogels.
abstract: Rational molecular design of self- assembling peptide-based materials that spontaneously form self-supporting hydrogels shows potential in many healthcare applications. Binary peptides based on complementary charged sequences are developed, and the use of biophysical analysis and cell-based studies highlights that the charged interactions can influence the properties of peptide materials and ultimately affect biomaterial applications.
authors.affiliation: Institute of Medical & Biological Engineering, Institute of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
authors.forename: Stuart
authors.initials: S
authors.lastname: Kyle
authors.forename: Susan H
authors.initials: SH
authors.lastname: Felton
authors.forename: Michael J
authors.initials: MJ
authors.lastname: McPherson
authors.forename: Amalia
authors.initials: A
authors.lastname: Aggeli
authors.forename: Eileen
authors.initials: E
authors.lastname: Ingham
mesh_terms: D001665:Binding Sites; D001672:Biocompatible Materials / Q000737:chemistry*; D049109:Cell Proliferation; D002470:Cell Survival; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011485:Protein Binding; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D010455:Peptides