title: The BioGRID interaction database: 2013 update.
abstract: The Biological General Repository for Interaction Datasets (BioGRID: http//thebiogrid.org) is an open access archive of genetic and protein interactions that are curated from the primary biomedical literature for all major model organism species. As of September 2012, BioGRID houses more than 500 000 manually annotated interactions from more than 30 model organisms. BioGRID maintains complete curation coverage of the literature for the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe and the model plant Arabidopsis thaliana. A number of themed curation projects in areas of biomedical importance are also supported. BioGRID has established collaborations and/or shares data records for the annotation of interactions and phenotypes with most major model organism databases, including Saccharomyces Genome Database, PomBase, WormBase, FlyBase and The Arabidopsis Information Resource. BioGRID also actively engages with the text-mining community to benchmark and deploy automated tools to expedite curation workflows. BioGRID data are freely accessible through both a user-defined interactive interface and in batch downloads in a wide variety of formats, including PSI-MI2.5 and tab-delimited files. BioGRID records can also be interrogated and analyzed with a series of new bioinformatics tools, which include a post-translational modification viewer, a graphical viewer, a REST service and a Cytoscape plugin.
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec, Canada H3C 3J7.
authors.forename: Andrew
authors.initials: A
authors.lastname: Chatr-Aryamontri
authors.forename: Bobby-Joe
authors.initials: BJ
authors.lastname: Breitkreutz
authors.forename: Sven
authors.initials: S
authors.lastname: Heinicke
authors.forename: Lorrie
authors.initials: L
authors.lastname: Boucher
authors.forename: Andrew
authors.initials: A
authors.lastname: Winter
authors.forename: Chris
authors.initials: C
authors.lastname: Stark
authors.forename: Julie
authors.initials: J
authors.lastname: Nixon
authors.forename: Lindsay
authors.initials: L
authors.lastname: Ramage
authors.forename: Nadine
authors.initials: N
authors.lastname: Kolas
authors.forename: Lara
authors.initials: L
authors.lastname: O'Donnell
authors.forename: Teresa
authors.initials: T
authors.lastname: Reguly
authors.forename: Ashton
authors.initials: A
authors.lastname: Breitkreutz
authors.forename: Adnane
authors.initials: A
authors.lastname: Sellam
authors.forename: Daici
authors.initials: D
authors.lastname: Chen
authors.forename: Christie
authors.initials: C
authors.lastname: Chang
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rust
authors.forename: Michael
authors.initials: M
authors.lastname: Livstone
authors.forename: Rose
authors.initials: R
authors.lastname: Oughtred
authors.forename: Kara
authors.initials: K
authors.lastname: Dolinski
authors.forename: Mike
authors.initials: M
authors.lastname: Tyers
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D030541:Databases, Genetic; D053263:Gene Regulatory Networks; D006801:Humans; D020407:Internet; D025941:Protein Interaction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism; D014584:User-Computer Interface