title: Effect of soy isoflavone supplementation on menopausal quality of life.
abstract: OBJECTIVE
  The purpose of this study was to assess the effect of soy isoflavone supplementation on quality of life in postmenopausal women.
  
  
  METHODS
  A multicenter, randomized, double-blind, placebo-controlled 24-month trial was conducted to assess the effect of 80 or 120 mg of daily aglycone hypocotyl soy isoflavone supplementation on quality of life in 403 postmenopausal women using a validated Menopause-Specific Quality of Life questionnaire.
  
  
  RESULTS
  Menopause-Specific Quality of Life domain scores at 1 year and 2 years were similar to baseline. There were no differences in domain scores among treatment groups.
  
  
  CONCLUSIONS
  Soy isoflavone supplementation offers no benefit to quality of life in postmenopausal women.
authors.affiliation: Oregon Health and Science University, Portland, OR 97239-4501, USA. amatop@ohsu.edu
authors.forename: Paula
authors.initials: P
authors.lastname: Amato
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Young
authors.forename: Francene M
authors.initials: FM
authors.lastname: Steinberg
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Murray
authors.forename: Richard D
authors.initials: RD
authors.lastname: Lewis
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Cramer
authors.forename: Stephen
authors.initials: S
authors.lastname: Barnes
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Ellis
authors.forename: Roman J
authors.initials: RJ
authors.lastname: Shypailo
authors.forename: Joe Kennard
authors.initials: JK
authors.lastname: Fraley
authors.forename: Karen L
authors.initials: KL
authors.lastname: Konzelmann
authors.forename: Joan G
authors.initials: JG
authors.lastname: Fischer
authors.forename: Colette
authors.initials: C
authors.lastname: LaSalle
authors.forename: Elliot O'Brian
authors.initials: EO
authors.lastname: Smith
authors.forename: William W
authors.initials: WW
authors.lastname: Wong
mesh_terms: D000328:Adult; D019587:Dietary Supplements; D004311:Double-Blind Method; D004717:Endometrium / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage* / Q000009:adverse effects; D008593:Menopause; D008875:Middle Aged; D010919:Placebos; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014463:Ultrasonography; D047071:beta-Glucans / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D007529:Isoflavones; D010919:Placebos; D047071:beta-Glucans; C508230:soy isoflavone aglycone