title: Synthetic studies towards bottromycin.
abstract: Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner.
authors.affiliation: Institute of Organic Chemistry, Saarland University, P.O. Box 151150, 66041 Saarbrücken, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Ackermann
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Lerchen
authors.forename: Dieter
authors.initials: D
authors.lastname: Häbich
authors.forename: Angelika
authors.initials: A
authors.lastname: Ullrich
authors.forename: Uli
authors.initials: U
authors.lastname: Kazmaier