title: Synthesis of amidine and bis amidine derivatives and their evaluation for anti-inflammatory and anticancer activity.
abstract: 2-Cyanopyridine (1a), 4-cyanopyridine (1b), 2-cyanopyrazine (1c) on condensation with mono amines (2a-c) and diamines (4a-c) in the presence of sodium methoxide as catalyst gave amidine derivatives (3a-i) and bis amidine derivatives (5a-i) in good yields. All these compounds were fully characterized by spectroscopic means and elemental analysis. On screening for anti-inflammatory activity and for in vitro anticancer activity compounds 5c and 5d exhibited good anti-inflammatory activity whereas compounds 5d breast (T47D), 5h, 5i lung (NCI H-522), 5i colon (HCT-15), 3c, 3h, 5i ovary (PA-1) and 3c, 5b, 5h liver (HepG2) exhibited good anticancer activity.
authors.affiliation: Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, 247667 UK, India.
authors.forename: Surbhi
authors.initials: S
authors.lastname: Arya
authors.forename: Nikhil
authors.initials: N
authors.lastname: Kumar
authors.forename: Partha
authors.initials: P
authors.lastname: Roy
authors.forename: S M
authors.initials: SM
authors.lastname: Sondhi
mesh_terms: D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D008297:Male; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000578:Amidines; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents