title: Pharmaceutical cocrystals and poorly soluble drugs.
abstract: In recent years cocrystal formation has emerged as a viable strategy towards improving the solubility and bioavailability of poorly soluble drugs. In this review the success of numerous pharmaceutical cocrystals for the improvement of the solubility and dissolution rates of poorly soluble drugs is demonstrated using various examples taken from the literature. The role of crystal engineering principles in the selection of appropriate coformers and the nature of the supramolecular synthons present within the crystals are described. Evidence for improved animal pharmacokinetic data is given for several systems. A summary is provided of our current understanding of the relationship between cocrystal structure and solution phase interactions on solubility as well as those factors that influence overall cocrystal thermodynamic stability.
authors.affiliation: Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
authors.forename: Ranjit
authors.initials: R
authors.lastname: Thakuria
authors.forename: Amit
authors.initials: A
authors.lastname: Delori
authors.forename: William
authors.initials: W
authors.lastname: Jones
authors.forename: Maya P
authors.initials: MP
authors.lastname: Lipert
authors.forename: Lilly
authors.initials: L
authors.lastname: Roy
authors.forename: Naír
authors.initials: N
authors.lastname: Rodríguez-Hornedo
mesh_terms: D000818:Animals; D003460:Crystallization; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism; D010599:Pharmacokinetics; D012995:Solubility
chemical_list: D004364:Pharmaceutical Preparations