title: Neurocognitive phenomics: examining the genetic basis of cognitive abilities.
abstract: Cognitive deficits are core to the disability associated with many psychiatric disorders. Both variation in cognition and psychiatric risk show substantial heritability, with overlapping genetic variants contributing to both. Unsurprisingly, therefore, these fields have been mutually beneficial : just as cognitive studies of psychiatric risk variants may identify genes involved in cognition, so too can genome-wide studies based on cognitive phenotypes lead to genes relevant to psychiatric aetiology. The purpose of this review is to consider the main issues involved in the phenotypic characterization of cognition, and to describe the challenges associated with the transition to genomewide approaches. We conclude by describing the approaches currently being taken by the international consortia involving many investigators in the field internationally (e.g. Cognitive Genomics Consortium; COGENT) to overcome these challenges.
authors.affiliation: Department of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Republic of Ireland. donoghug@tcd.ie
authors.forename: G
authors.initials: G
authors.lastname: Donohoe
authors.forename: I J
authors.initials: IJ
authors.lastname: Deary
authors.forename: D C
authors.initials: DC
authors.lastname: Glahn
authors.forename: A K
authors.initials: AK
authors.lastname: Malhotra
authors.forename: K E
authors.initials: KE
authors.lastname: Burdick
mesh_terms: D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000235:genetics*; D058068:Endophenotypes; D023281:Genomics / Q000379:methods*; D006801:Humans