title: Delivery of ricin toxin a-chain by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.
abstract: Mesoporous silica nanoparticle-supported lipid bilayers, or "protocells", exhibit a high loading capacity, enhanced colloidal stability, and peptide-directed, cell-specific uptake, making them especially well-suited for targeted delivery of protein toxins to cancer. Protocells loaded with ricin toxin A-chain (RTA) and targeted to hepatocellular carcinoma cause complete cell death at 30 pM of RTA without affecting the viability of control hepatocytes.
authors.affiliation: Center for Micro-Engineered Materials, University of New Mexico, 1 University of New Mexico, MSC 01-1120, Albuquerque, NM 87131, USA.
authors.forename: Katharine
authors.initials: K
authors.lastname: Epler
authors.forename: David
authors.initials: D
authors.lastname: Padilla
authors.forename: Genevieve
authors.initials: G
authors.lastname: Phillips
authors.forename: Peter
authors.initials: P
authors.lastname: Crowder
authors.forename: Robert
authors.initials: R
authors.lastname: Castillo
authors.forename: Dan
authors.initials: D
authors.lastname: Wilkinson
authors.forename: Brian
authors.initials: B
authors.lastname: Wilkinson
authors.forename: Cameron
authors.initials: C
authors.lastname: Burgard
authors.forename: Robin
authors.initials: R
authors.lastname: Kalinich
authors.forename: Jason
authors.initials: J
authors.lastname: Townson
authors.forename: Bryce
authors.initials: B
authors.lastname: Chackerian
authors.forename: Cheryl
authors.initials: C
authors.lastname: Willman
authors.forename: David
authors.initials: D
authors.lastname: Peabody
authors.forename: Walker
authors.initials: W
authors.lastname: Wharton
authors.forename: C Jeffrey
authors.initials: CJ
authors.lastname: Brinker
authors.forename: Carlee
authors.initials: C
authors.lastname: Ashley
authors.forename: Eric
authors.initials: E
authors.lastname: Carnes
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry*; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry*; D016062:Porosity; D012276:Ricin / Q000008:administration & dosage* / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D008051:Lipid Bilayers; D053769:Nanocapsules; D012822:Silicon Dioxide; D012276:Ricin