title: A new phosphorylcholine-coated polymethylpentene oxygenator for extracorporeal membrane oxygenation: a preliminary experience.
abstract: Phosphorylcholine coating has a major role in the improvement of biocompatibility, durability and antihrombogenicity of the circuit for extracorporeal membrane oxygenation (ECMO). Moreover, if heparin-induced thrombocytopenia ensues, removal of all the sources of heparin is challenging if the circuit is coated with heparin. We report our preliminary experience with the new EUROSETS A.L.ONE ECMO oxygenator (Eurosets, Medolla, MO, Italy), which is aimed at providing better biocompatibility thanks to its full coating with phosphorylcholine. We retrospectively collected data on the 16 patients supported with ECMO and with the EUROSETS A.L.ONE ECMO oxygenator at San Raffaele Hospital. Mean ECMO duration was 6 ± 4 days, and 37.5% of the patients died on ECMO. Four episodes of major bleeding and three episodes of minor bleeding were recorded. The oxygenator had an excellent performance in gas exchange and the median pressure drop was 57 (26-85) mmHg at full blood flow (2.5 L/m2/min). The EUROSETS A.L.ONE ECMO oxygenator was an excellent device in our preliminary experience. Further evaluation on a larger sample is encouraged.
authors.affiliation: Department of Cardiac Anesthesia and Intensive Care, Vita-Salute San Raffaele University, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pieri
authors.forename: O G
authors.initials: OG
authors.lastname: Turla
authors.forename: M G
authors.initials: MG
authors.lastname: Calabrò
authors.forename: L
authors.initials: L
authors.lastname: Ruggeri
authors.forename: N
authors.initials: N
authors.lastname: Agracheva
authors.forename: A
authors.initials: A
authors.lastname: Zangrillo
authors.forename: F
authors.initials: F
authors.lastname: Pappalardo
mesh_terms: D000368:Aged; D016063:Blood Loss, Surgical / Q000517:prevention & control; D020099:Coated Materials, Biocompatible; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010767:Phosphorylcholine; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D020099:Coated Materials, Biocompatible; D010767:Phosphorylcholine