title: TXNDC9 expression in colorectal cancer cells and its influence on colorectal cancer prognosis.
abstract: In this study, we analyzed the protein expression of thioredoxin domain containing 9 (TXNDC9) in 116 colorectal cancer (CRC) cases. Among them, 97 were positive in CRC tissues and 60 were positive in normal mucosa. TXNDC9 expression in CRC was correlated with the extent of tumor invasion and the tumor size. TXNDC9-negative patients had longer lifespans. In vitro assays showed the significant suppression of CRC cell proliferation (P < .01) compared with two control groups; the number of invaded cells also decreased (P < .01). These findings suggest that TXNDC9 gene may function in cancer development and may be an effective target for inhibiting the growth and metastasis of CRC cells.
authors.affiliation: Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai, China.
authors.forename: Aiguo
authors.initials: A
authors.lastname: Lu
authors.forename: Xiongzhi
authors.initials: X
authors.lastname: Wangpu
authors.forename: Dingpei
authors.initials: D
authors.lastname: Han
authors.forename: Hao
authors.initials: H
authors.lastname: Feng
authors.forename: Jingkun
authors.initials: J
authors.lastname: Zhao
authors.forename: Junjun
authors.initials: J
authors.lastname: Ma
authors.forename: Shun
authors.initials: S
authors.lastname: Qu
authors.forename: Xuehua
authors.initials: X
authors.lastname: Chen
authors.forename: Bingya
authors.initials: B
authors.lastname: Liu
authors.forename: Minhua
authors.initials: M
authors.lastname: Zheng
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D015153:Blotting, Western; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics*; D011379:Prognosis; D013879:Thioredoxins / Q000235:genetics* / Q000378:metabolism*; D046888:Tissue Array Analysis; D014162:Transfection
chemical_list: D014408:Biomarkers, Tumor; D013879:Thioredoxins