title: Genetics of inflammatory bowel diseases: a comparison between Western and Eastern perspectives.
abstract: Inflammatory bowel disease (IBD) is a chronic relapsing intestinal inflammatory disorder with unidentified causes. Currently, studies indicate that IBD results from a complex interplay between various genetic and environmental factors that produce intestinal inflammation. However, these factors may differ for Asians and Caucasians. Thus, differences in epidemiology, genetic variants, and clinical phenotypes of IBD have been observed between the two populations. Understanding the discrepancies between data from populations with different genetic backgrounds and environmental factors may reveal fundamental aspects of IBD pathogenesis. Accordingly, this review will summarize the current knowledge of IBD genetics studied in Asian countries and compare it with that from Western countries, with special focus on innate bacterial sensing, autophagy, and the interleukin-23 receptor-T helper cell 17 pathway. The epigenetic nature of IBD pathogenesis as well as the pharmacogenetics related to the use of immunomodulators will also be briefly covered.
authors.affiliation: Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea. geniushee@yuhs.ac
authors.forename: Jae Hee
authors.initials: JH
authors.lastname: Cheon
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001208:Asia / Q000453:epidemiology; D044466:Asian People / Q000235:genetics*; D044127:Epigenesis, Genetic; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D059647:Gene-Environment Interaction; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D010597:Pharmacogenetics; D012307:Risk Factors; D019366:Western World; D044465:White People / Q000235:genetics*
chemical_list: D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents; D005819:Genetic Markers