title: Core-shell hydrogel microcapsules for improved islets encapsulation.
abstract: Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.
authors.affiliation: David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
authors.forename: Minglin
authors.initials: M
authors.lastname: Ma
authors.forename: Alan
authors.initials: A
authors.lastname: Chiu
authors.forename: Gaurav
authors.initials: G
authors.lastname: Sahay
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Doloff
authors.forename: Nimit
authors.initials: N
authors.lastname: Dholakia
authors.forename: Raj
authors.initials: R
authors.lastname: Thakrar
authors.forename: Joshua
authors.initials: J
authors.lastname: Cohen
authors.forename: Arturo
authors.initials: A
authors.lastname: Vegas
authors.forename: Delai
authors.initials: D
authors.lastname: Chen
authors.forename: Kaitlin M
authors.initials: KM
authors.lastname: Bratlie
authors.forename: Tram
authors.initials: T
authors.lastname: Dang
authors.forename: Roger L
authors.initials: RL
authors.lastname: York
authors.forename: Jennifer
authors.initials: J
authors.lastname: Hollister-Lock
authors.forename: Gordon C
authors.initials: GC
authors.lastname: Weir
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Anderson
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis; D002214:Capsules / Q000138:chemical synthesis*; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000473:pathology / Q000601:surgery*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000008:administration & dosage* / Q000138:chemical synthesis*; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016062:Porosity; D013311:Streptozocin; D054457:Tissue Scaffolds; D016896:Treatment Outcome
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D002214:Capsules; D006603:Hexuronic Acids; D020100:Hydrogels; D013311:Streptozocin; D020723:Glucuronic Acid