title: A new approach to primary ovarian insufficiency.
abstract: There is a need for a new approach to managing women with primary ovarian insufficiency. This condition is a serious chronic disease that may have far reaching effects on physical and emotional health. An integrative and collaborative approach to management works best. To maintain wellness, most women with primary ovarian insufficiency need to reassess their primary source of meaning and purpose in life and how this diagnosis may have threatened that part of who they are. They also need assessment with regard to bone health, thyroid and adrenal function, determination of FMR1 premutation and karyotype status, and ongoing estradiol-progestin hormone replacement.
authors.affiliation: Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, CRC, Room 1-3140, Bethesda, MD 20892-1109, USA.
authors.forename: Saima
authors.initials: S
authors.lastname: Rafique
authors.forename: Evelina W
authors.initials: EW
authors.lastname: Sterling
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: Nelson
mesh_terms: D000328:Adult; D003376:Counseling; D004958:Estradiol / Q000008:administration & dosage; D015914:Estrogen Replacement Therapy / Q000379:methods; D005260:Female; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics*; D006801:Humans; D008594:Menopause, Premature / Q000235:genetics* / Q000523:psychology; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology; D011372:Progestins / Q000008:administration & dosage; D011379:Prognosis
chemical_list: D004958:Estradiol; D051860:Fragile X Messenger Ribonucleoprotein 1; D011372:Progestins; C497683:FMR1 protein, human