title: Impact of TAVI on mitral regurgitation: a prospective echocardiographic study.
abstract: OBJECTIVE
  This study aims to assess changes in mitral regurgitation (MR) severity after transcatheter aortic valve implantation (TAVI).
  
  
  BACKGROUND
  Existing data on MR after TAVI are contradictory.
  
  
  METHODS
  Thirty-five patients with MR graded ≥ 2+ were followed after undergoing TAVI with either the Edwards Sapien or CoreValve device. Echocardiography was performed the week before and 3 months after the procedure. MR was graded on a scale of 0 to 4+, classified as organic or functional, and the effective regurgitant orifice area (EROA) and MR index were calculated.
  
  
  RESULTS
  At baseline, MR was graded 4+ in 4 (11.4%) patients, 3+  in 10 (28.6%), and 2+ in 21 (60%). At follow-up, MR was graded at 3+ in 4 (11.4%) patients, 2+ in 8 (22.9%), and 1+ in 19 (54.3%); 4 (11.4%) exhibited no MR. EROA (24.4 ± 11.5 mm(2) pre-TAVI vs. 11.2 ± 10.3 mm(2) post-TAVI, P < 0.001) and MR index (1.9 ± 0.3 pre-TAVI vs. 1.3 ± 0.7 post-TAVI, P < 0.001) were reduced with TAVI, independent of the etiology. MR decreased by at least 1 grade in 28 (80%) patients, with a reduction ≥2 grades in 10 (28.6%) patients; no patient showed a worsened condition. Subgroup analyses showed that the reduction in MR was significant in patients treated with the Edwards Sapien device but not in patients treated with the CoreValve device.
  
  
  CONCLUSIONS
  This multiparametric echocardiographic evaluation showed that MR improved significantly after TAVI and that this result may be related to the type of valve implanted.
authors.affiliation: Medical Sciences Department, San Giovanni Battista Molinette Hospital, University of Torino, Italy. francy.giordana@libero.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Giordana
authors.forename: Michele
authors.initials: M
authors.lastname: Capriolo
authors.forename: Simone
authors.initials: S
authors.lastname: Frea
authors.forename: Walter Grosso
authors.initials: WG
authors.lastname: Marra
authors.forename: Mauro
authors.initials: M
authors.lastname: Giorgi
authors.forename: Laura
authors.initials: L
authors.lastname: Bergamasco
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Omedè
authors.forename: Imad
authors.initials: I
authors.lastname: Sheiban
authors.forename: Maurizio
authors.initials: M
authors.lastname: D'Amico
authors.forename: Virginia
authors.initials: V
authors.lastname: Bovolo
authors.forename: Stefano
authors.initials: S
authors.lastname: Salizzoni
authors.forename: Michele
authors.initials: M
authors.lastname: La Torre
authors.forename: Mauro
authors.initials: M
authors.lastname: Rinaldi
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Marra
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Gaita
authors.forename: Mara
authors.initials: M
authors.lastname: Morello
mesh_terms: D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome