title: Inhibitory effects of the lichen metabolite lobaric acid on arachidonate metabolism in vitro.
abstract: An extract containing phenolic constituents of the lichen Stereocaulon alpinum was shown to exhibit potent in vitro inhibitory effects on arachidonate 5-lipoxygenase from porcine leucocytes. The active component has been identified as the orcinol depsidone lobaric acid (1), which shows dose-dependent inhibitory effects on the enzyme, with an IC(50) value of 7.3 μM. Lobaric acid exhibits approximately 4-fold in vitro selectivity for 5-lipoxygenase as compared to cyclooxygenase.
authors.affiliation: Dept. of Pharmacy, University of Iceland, Hagi/Hofsvallagata, IS-107 Reykjavik, Iceland.
authors.forename: K
authors.initials: K
authors.lastname: Ingolfsdottir
authors.forename: S R
authors.initials: SR
authors.lastname: Gissurarson
authors.forename: B
authors.initials: B
authors.lastname: Müller-Jakic
authors.forename: W
authors.initials: W
authors.lastname: Breu
authors.forename: H
authors.initials: H
authors.lastname: Wagner