title: Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age.
abstract: OBJECTIVE
  The study was performed to determine whether catch-up growth is associated with the development of insulin resistance and to explore serum endocrine markers associated with the metabolism of adipose tissue in a Chinese population born small for gestational age(SGA) SUBJECTS AND METHODS: We recruited 56 children born SGA with catch-up growth and 55 born without catch-up growth, who were further grouped into groups I (with BMI catch-up) and II (without BMI catch-up) respectively, as well as 52 children born appropriate for gestational age (AGA) with normal height. Their serum fasting insulin, fasting glucose, insulin-like growth factor-1, adiponectin, IGFBP-1, triglyceride concentrations, and the homeostasis assessment model for insulin resistance (HOMA-IR) were evaluated.
  
  
  RESULTS
  (1) The HOMA-IR values in SGA-I with catch-up growth group were significantly higher than those in SGA-II with catch-up growth, SGA-I without catch-up growth and AGA children respectively. (2) The serum adiponectin levels of individuals in the SGA-I without catch-up growth and SGA-II with catch-up growth groups were significantly lower than those from the SGA-II without catch-up growth group. There was no difference in triglyceride or IGFBP-1 levels among the groups. (3) The degree of HOMA-IR was positively correlated with age, current BMI and △height SDS in SGA children.
  
  
  CONCLUSIONS
  The development of insulin resistance and lower levels of adiponectin were closely correlated with higher BMI and the postnatal height catch-up growth in SGA children.
authors.affiliation: Department of Pediatrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.|Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Hong-Zhu
authors.initials: HZ
authors.lastname: Deng
authors.affiliation: Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Li
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Hua-Mei
authors.initials: HM
authors.lastname: Ma
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Hong-Shan
authors.initials: HS
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Min-Lian
authors.initials: ML
authors.lastname: Du