title: PPAR-γ agonistic metabolites from the ascidian Herdmania momus.
abstract: Seven new amino acid derivatives (1-4 and 6-8) were isolated from MeOH extracts of the marine ascidian Herdmania momus. Planar structures were established on the basis of NMR, IR, and MS spectroscopic analyses. Absolute configurations of these compounds were derived from specific rotation and CD analysis. The peroxisome proliferator-activated receptor (PPAR)-γ agonistic activities of the compounds were investigated due to the similarity of the structural motif to that of the antidiabetic drug rosiglitazone. Analogues with indoleglyoxyl moieties (5, 6, and 8) showed significant PPAR-γ activation in Ac2F rat liver cells.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea.
authors.forename: Jian Lin
authors.initials: JL
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Xiao
authors.forename: Minhi
authors.initials: M
authors.lastname: Park
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Yoo
authors.forename: Sook
authors.initials: S
authors.lastname: Shin
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Hae Young
authors.initials: HY
authors.lastname: Chung
authors.forename: Hyung Sik
authors.initials: HS
authors.lastname: Kim
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D047495:PPAR gamma / Q000819:agonists*; D051381:Rats; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry*
chemical_list: D007004:Hypoglycemic Agents; D007211:Indoles; D047495:PPAR gamma; D045162:Thiazolidinediones; C578631:herdmanine E; D000077154:Rosiglitazone