title: Epithelial to mesenchymal transition in head and neck squamous cell carcinoma.
abstract: Epithelial to mesenchymal transition (EMT) is a dynamic cellular process that is essential for the development of metastatic disease. During EMT, a tumor cell with epithelial characteristics transitions to a tumor cell with mesenchymal characteristics through modulation of cell polarity and adhesion. Two hallmark EMT proteins, E-Cadherin and Vimentin, are tightly controlled during EMT through multiple signal transduction pathways. Epidermal growth factor (EGF) and transforming growth factorβ (TGFβ) promote EMT by regulating a distinct set of transcription factors, including Snail and Twist. Snail, Twist, and Slug are integral to the induction of EMT through direct regulation of genes involved in cellular adhesion, migration, and invasion. This review highlights the current literature on EMT in HNSCC. Understanding the role of EMT will provide insight to the pathogenesis of disease progression and may lead to the development of novel anti-cancer therapeutics for metastatic HNSCC.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center at Ohio State University, 442 Tzagournis Medical Research, 420 West 12th Avenue, Columbus, OH 43210, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: Smith
authors.forename: Theodoros N
authors.initials: TN
authors.lastname: Teknos
authors.forename: Quintin
authors.initials: Q
authors.lastname: Pan
mesh_terms: D015820:Cadherins / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: D015820:Cadherins; D016212:Transforming Growth Factor beta; D014746:Vimentin