title: An experimental study to compare inflammatory response due to liquid or gas joint distension in horses submitted to arthroscopy.
abstract: OBJECTIVE
  To assess comparatively the inflammatory response that follows CO(2) or Ringer's lactate joint capsular distension of horses submitted to experimental arthroscopy
  
  
  METHODS
  Each animal was submitted to a bilateral tarsocrural arthroscopy employing gas distention in one joint and fluid distention in the contralateral joint. Synovial fluid was evaluated at 0, six, 12, 24 and 48 hours post-operative.
  
  
  RESULTS
  The use of CO(2) for arthroscopy causes an acute and mild synovitis alike to the liquid capsular distension, showing similar synovial fluid increase of leukocytes, TP, and TNF-α. Although synovial fluid PGE(2) content was higher in joints submitted to CO(2) distension, lower levels of hemoglobin and leukocytes oxidative burst after surgery indicates that CO(2) arthroscopy decreased intra-articular bleeding and activation of infiltrating leukocytes.
  
  
  CONCLUSIONS
  The use of CO(2) for arthroscopic examination causes acute and mild synovitis that is similar to the effects caused by the liquid capsular distension. CO2 also seems to decrease intra-articular bleeding and activation of leukocytes.
authors.affiliation: Faculty of Veterinary Medicine, USP, Sao Paulo, Brazil.
authors.forename: Renata Bello
authors.initials: RB
authors.lastname: Rossetti
authors.forename: Cristina de Oliveira
authors.initials: Cde O
authors.lastname: Massoco
authors.forename: Ana Carolina Alves
authors.initials: AC
authors.lastname: Penna
authors.forename: Luis Claudio Lopes Correia da
authors.initials: LC
authors.lastname: Silva
mesh_terms: D000818:Animals; D001182:Arthroscopy / Q000379:methods / Q000662:veterinary*; D002245:Carbon Dioxide / Q000008:administration & dosage; D005260:Female; D005434:Flow Cytometry; D006736:Horses; D007270:Injections, Intra-Articular / Q000662:veterinary; D007327:Insufflation / Q000009:adverse effects / Q000379:methods / Q000662:veterinary*; D007596:Joints / Q000601:surgery*; D008297:Male; D013582:Synovial Fluid; D013585:Synovitis / Q000209:etiology
chemical_list: D002245:Carbon Dioxide