title: Human blood analysis reveals differences in gene expression of catecholamine-regulated protein 40 (CRP40) in schizophrenia.
abstract: Heat shock proteins (HSPs) are important players in neurodegeneration and psychiatric disorders. We previously reported significant reductions of a 40-kDa Catecholamine Regulated Protein (CRP40) in schizophrenia post-mortem brain specimens. This study investigated whether gene expression of CRP40 is altered in living subjects with schizophrenia. CRP40 mRNA was analyzed in white blood cells of first episode and chronic/treated schizophrenia subjects compared to healthy controls. Significant reductions in CRP40 mRNA were found among first episode schizophrenia subjects and chronic schizophrenia subjects compared to healthy controls (p<0.05 for both). These results suggest a possible functional role of CRP40 in the pathogenesis of schizophrenia.
authors.affiliation: Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Groleau
authors.forename: Jovana
authors.initials: J
authors.lastname: Lubarda
authors.forename: Nancy
authors.initials: N
authors.lastname: Thomas
authors.forename: Mark A
authors.initials: MA
authors.lastname: Ferro
authors.forename: Zdenek B
authors.initials: ZB
authors.lastname: Pristupa
authors.forename: Ram K
authors.initials: RK
authors.lastname: Mishra
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Gabriele
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001773:Blood Cells / Q000378:metabolism*; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D018840:HSP70 Heat-Shock Proteins / Q000097:blood* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000097:blood* / Q000235:genetics; D012333:RNA, Messenger / Q000097:blood; D012559:Schizophrenia / Q000097:blood* / Q000235:genetics*
chemical_list: D018840:HSP70 Heat-Shock Proteins; C492001:HSPA9 protein, human; D024101:Mitochondrial Proteins; D012333:RNA, Messenger