title: Asymmetric cyclopropanation of olefins catalysed by Cu(I) complexes of chiral pyridine-containing macrocyclic ligands (Pc-L*).
abstract: The synthesis and characterisation of copper(I) complexes of chiral pyridine-containing macrocyclic ligands (Pc-L*) and their use as catalysts in asymmetric cyclopropanation reactions are reported. All ligands and metal complexes were fully characterised, including crystal structures of some species determined by X-ray diffraction on single crystals. This allowed characterising the very different conformations of the macrocycles which could be induced by different substituents or by metal complexation. The strategy adopted for the ligand synthesis is very flexible allowing several structural modifications. A small library of macrocyclic ligands possessing the same donor properties but with either C(1) or C(2) symmetry was synthesized. Cyclopropane products with both aromatic and aliphatic olefins were obtained in good yields and enantiomeric excesses up to 99%.
authors.affiliation: Dipartimento di Chimica, Università di Milano, Via Golgi 19, 20133 Milano, Italy.
authors.forename: Brunilde
authors.initials: B
authors.lastname: Castano
authors.forename: Stefano
authors.initials: S
authors.lastname: Guidone
authors.forename: Emma
authors.initials: E
authors.lastname: Gallo
authors.forename: Fabio
authors.initials: F
authors.lastname: Ragaini
authors.forename: Nicola
authors.initials: N
authors.lastname: Casati
authors.forename: Piero
authors.initials: P
authors.lastname: Macchi
authors.forename: Massimo
authors.initials: M
authors.lastname: Sisti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Caselli
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000475:Alkenes; D003521:Cyclopropanes; D008024:Ligands; D047028:Macrocyclic Compounds; D009942:Organometallic Compounds; D011725:Pyridines; D003300:Copper; C023666:pyridine