title: Zebrafish: an in vivo model for nano EHS studies.
abstract: To assure a responsible and sustainable growth of nanotechnology, the environmental health and safety (EHS) aspect of engineered nanomaterials and nano-related products needs to be addressed at a rate commensurate with the expansion of nanotechnology. Zebrafish has been demonstrated as a correlative in vivo vertebrate model for such task, and the current advances of using zebrafish for nano EHS studies are summarized here. In addition to morphological and histopathological observations, the accessibility of gene manipulation would greatly empower such a model for detailed mechanistic studies of any nanoparticles of interest. The potential for establishing high-throughput screening platforms to facilitate the nano EHS studies is highlighted, and a discussion is presented on how toxicogenomics approaches represent a future direction to guide the identification of toxicity pathways.
authors.affiliation: Center for Environmental Implications of Nanotechnology, 570 Westwood Plaza, Bldg114, Rm 6511, Los Angeles, CA 90095, USA.
authors.forename: Sijie
authors.initials: S
authors.lastname: Lin
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: André E
authors.initials: AE
authors.lastname: Nel
authors.forename: Shuo
authors.initials: S
authors.lastname: Lin
mesh_terms: D000818:Animals; D004782:Environmental Health; D004784:Environmental Monitoring / Q000379:methods*; D008954:Models, Biological; D036103:Nanotechnology; D015027:Zebrafish