title: Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy.
abstract: We investigate morphological differences in three-dimensional (3-D) images with cellular resolution between nonmelanoma skin cancer and normal skin using Gabor domain optical coherence microscopy. As a result, we show for the first time cellular optical coherence images of 3-D features differentiating cancerous skin from normal skin. In addition, in vivo volumetric images of normal skin from different anatomic locations are shown and compared.
authors.affiliation: University of Rochester, The Institute of Optics, 275 Hutchinson Road, Rochester, New York 14627, USA.
authors.forename: Kye-Sung
authors.initials: KS
authors.lastname: Lee
authors.forename: Huimin
authors.initials: H
authors.lastname: Zhao
authors.forename: Sherrif F
authors.initials: SF
authors.lastname: Ibrahim
authors.forename: Natthani
authors.initials: N
authors.lastname: Meemon
authors.forename: Laura
authors.initials: L
authors.lastname: Khoudeir
authors.forename: Jannick P
authors.initials: JP
authors.lastname: Rolland
mesh_terms: D000465:Algorithms; D046169:Dermoscopy / Q000379:methods*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008545:Melanoma / Q000473:pathology; D008853:Microscopy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*