title: Differential seizure response in two models of cortical heterotopia.
abstract: Malformations of cortical development (MCD) are linked to epilepsy in humans. MCD encompass a broad spectrum of malformations, which occur as the principal pathology or a secondary disruption. Recently, Rosen et al. (2012) reported that BXD29-Trl4(lps-2J)/J mice have subcortical nodular heterotopias with partial agenesis of the corpus callosum (p-ACC). Additionally Ramos et al. (2008) demonstrated that C57BL/10J mice exhibit cortical heterotopias with no additional cortical abnormalities. We examined the seizure susceptibility of these mice to determine if the presence (BXD29-Trl4(lps-2J)/J) or absence (C57BL/10J) of p-ACC, in strains with MCD, confers a differential response to chemi-convulsive treatment. Our results indicate that C57BL/10J mice with layer I heterotopia are more susceptible, whereas BXD29-Trl4(lps-2J)/J mice with more severe subcortical nodular heterotopia and p-ACC are more resistant to seizure behavior induced by pentylenetetrazole. These data suggest that p-ACC may confer seizure resistance in models of MCD.
authors.affiliation: Department of Psychology, Lafayette College, Easton, PA, United States. gabell@lafayette.edu
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Gabel
authors.forename: Monica
authors.initials: M
authors.lastname: Manglani
authors.forename: Natalia
authors.initials: N
authors.lastname: Ibanez
authors.forename: Jessica
authors.initials: J
authors.lastname: Roberts
authors.forename: Raddy L
authors.initials: RL
authors.lastname: Ramos
authors.forename: Glenn D
authors.initials: GD
authors.lastname: Rosen
mesh_terms: D061085:Agenesis of Corpus Callosum / Q000150:complications* / Q000473:pathology; D000818:Animals; D002540:Cerebral Cortex; D002828:Choristoma / Q000150:complications* / Q000473:pathology; D003292:Convulsants; D004195:Disease Models, Animal; D060467:Disease Resistance; D004198:Disease Susceptibility; D004827:Epilepsy / Q000209:etiology / Q000473:pathology*; D005260:Female; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008818:Mice, Neurologic Mutants; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000473:pathology*
chemical_list: D003292:Convulsants; D010433:Pentylenetetrazole