title: Outcomes of photorefractive keratectomy with intraoperative mitomycin-C.
abstract: OBJECTIVE
  To report the efficacy, safety, predictability and complications of photorefractive keratectomy (PRK) with intraoperative application of mitomycin-C (MMC).
  
  
  METHODS
  This historical cohort study was performed on 1,250 eyes of 625 patients who underwent PRK using the Technolas 217 excimer laser machine by a single surgeon with intraoperative use of MMC 0.02% up to 2 minutes, depending on depth of ablation. A complete ophthalmologic examination was performed which included refraction uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA) and slitlamp biomicroscopy. Outcomes were analyzed after one year of follow-up.
  
  
  RESULTS
  The mean preoperative spherical equivalent refractive error was -4.85±2.27 (range, -2.50 to -13.5) diopters (D). Mean depth of ablation was 89±22 microns and mean time to reepithelialization was 4.5±1.7 days. At final follow-up, UCVA of 20/20 and 20/40 or more was achieved in 92.1% and 99.2% of eyes, respectively. One year postoperatively, 69.4% and 91% of eyes were within ±0.50 D and ±1.00 D of emmetropia.Overall, 62 eyes (4.9%) developed one or two lines of decrease in BCVA, and 50 eyes (4%) developed corneal haze which was grade 1 or 2 in most cases; grade 3 and 4 corneal haze was found in 4 and 2 eyes, respectively. No other adverse event was noted during the study period.
  
  
  CONCLUSIONS
  PRK with intraoperative application of MMC provides excellent visual outcomes with acceptable safety and predictability, and entails minimal side effects.
authors.affiliation: Persian Eye Clinic, Isfahan Medical University, Isfahan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ghoreishi
authors.forename: Hossein
authors.initials: H
authors.lastname: Attarzadeh
authors.forename: Alireza
authors.initials: A
authors.lastname: Zandi
authors.forename: Heidar-Ali
authors.initials: HA
authors.lastname: Moini
authors.forename: Mehdi
authors.initials: M
authors.lastname: Tavakoli
authors.forename: Hamid
authors.initials: H
authors.lastname: Fesharaki
authors.forename: Kobra
authors.initials: K
authors.lastname: Nasrollahi