title: Tandem cyclization of α-cyano α-alkynyl aryl ketones induced by tert-butyl hydroperoxide and tetrabutylammonium iodide.
abstract: The radical cascade protocol of the α-cyano α-TMS/aryl-capped alkynyl aryl ketones promoted by tert-butyl hydroperoxide under catalysis with tetrabutylammonium iodide in refluxing benzene has been developed, leading to the construction of a variety of highly functionalized [6,6,5] tricyclic frameworks in an efficient manner.
authors.affiliation: Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, R. O. C.
authors.forename: Ying-Chieh
authors.initials: YC
authors.lastname: Wong
authors.forename: Chen-Tso
authors.initials: CT
authors.lastname: Tseng
authors.forename: Tzu-Ting
authors.initials: TT
authors.lastname: Kao
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Yeh
authors.forename: Kak-Shan
authors.initials: KS
authors.lastname: Shia
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D020122:tert-Butylhydroperoxide / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006847:Hydrocarbons, Iodinated; D007659:Ketones; D000644:Quaternary Ammonium Compounds; D020122:tert-Butylhydroperoxide; C009405:tetrabutylammonium