title: Association of the interleukin 1 beta gene and brain spontaneous activity in amnestic mild cognitive impairment.
abstract: OBJECTIVE
  The inflammatory response has been associated with the pathogenesis of Alzheimer's disease (AD). The purpose of this study is to determine whether the rs1143627 polymorphism of the interleukin-1 beta (IL-1β) gene moderates functional magnetic resonance imaging (fMRI)-measured brain regional activity in amnestic mild cognitive impairment (aMCI).
  
  
  METHODS
  Eighty older participants (47 with aMCI and 33 healthy controls) were recruited for this study. All of the participants were genotyped for variant rs1143627 in the IL1B gene and were scanned using resting-state fMRI. Brain activity was assessed by amplitude of low-frequency fluctuation (ALFF).
  
  
  RESULTS
  aMCI patients had abnormal ALFF in many brain regions, including decreases in the inferior frontal gyrus, the superior temporal lobe and the middle temporal lobe, and increases in the occipital cortex (calcarine), parietal cortex (Pcu) and cerebellar cortex. The regions associated with an interaction of group X genotypes of rs1143627 C/T were the parietal cortex (left Pcu), frontal cortex (left superior, middle, and medial gyrus, right anterior cingulum), occipital cortex (left middle lobe, left cuneus) and the bilateral posterior lobes of the cerebellum. Regarding the behavioral significance, there were significant correlations between ALFF in different regions of the brain and with the cognitive scores of each genotype group.
  
  
  CONCLUSIONS
  The present study provided evidence that aMCI patients had abnormal ALFF in many brain regions. Specifically, the rs1143627 C/T polymorphism of the IL1B gene may modulate regional spontaneous brain activity in aMCI patients.
authors.affiliation: Medical School of Southeast University, Nanjing, Jiangsu 210009, China.
authors.forename: Liying
authors.initials: L
authors.lastname: Zhuang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Xu
authors.forename: Chunxian
authors.initials: C
authors.lastname: Yue
authors.forename: Hao
authors.initials: H
authors.lastname: Shu
authors.forename: Feng
authors.initials: F
authors.lastname: Bai
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Shi
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002681:China; D060825:Cognitive Dysfunction / Q000208:ethnology / Q000235:genetics* / Q000473:pathology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted; D053583:Interleukin-1beta / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013223:Statistics as Topic
chemical_list: D053583:Interleukin-1beta