title: Translational Concepts of mGluR5 in Synaptic Diseases of the Brain.
abstract: The G-protein coupled receptor family of glutamate receptors, termed metabotropic glutamate receptors (mGluRs), are implicated in numerous cellular mechanisms ranging from neural development to the processing of cognitive, sensory, and motor information. Over the last decade, multiple mGluR-related signal cascades have been identified at excitatory synapses, indicating their potential roles in various forms of synaptic function and dysfunction. This review highlights recent studies investigating mGluR5, a subtype of group I mGluRs, and its association with a number of developmental, psychiatric, and senile synaptic disorders with respect to associated synaptic proteins, with an emphasis on translational pre-clinical studies targeting mGluR5 in a range of synaptic diseases of the brain.
authors.affiliation: School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol Bristol, UK.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Piers
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Byeong C
authors.initials: BC
authors.lastname: Kim
authors.forename: Philip
authors.initials: P
authors.lastname: Regan
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Whitcomb
authors.forename: Kwangwook
authors.initials: K
authors.lastname: Cho