title: Ceramide stress in survival versus lethal autophagy paradox: ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
abstract: In a recent study, characterization of novel mechanisms that regulate lethal autophagy revealed that C 18-ceramide stress mediates LC3B-II-ceramide binding on mitochondrial membranes to target autophagosomes for mitophagy induction and tumor suppression.
authors.affiliation: Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Charleston, SC, USA.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Jiang
authors.forename: Besim
authors.initials: B
authors.lastname: Ogretmen
mesh_terms: D000818:Animals; D001343:Autophagy / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002518:Ceramides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000187:drug effects / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D063306:Mitophagy / Q000187:drug effects*; D008954:Models, Biological; D010088:Oxidoreductases / Q000378:metabolism; D010588:Phagosomes / Q000187:drug effects / Q000378:metabolism*; D013312:Stress, Physiological / Q000187:drug effects*
chemical_list: D002518:Ceramides; D024101:Mitochondrial Proteins; D010088:Oxidoreductases; C108138:dihydroceramide desaturase