title: Serum levels of the CC chemokines CCL2, CCL5, and CCL11 in food allergic children with different clinical manifestations.
abstract: Food allergies (FA) are frequent in 8 % of children under 3 years old and approximately 2 % of adults. Chemokine are involved in various allergies such as FA. The present study was aimed to determine CCL2, CCL5, and CCL11 levels in FA. The study population of this cross-sectional study contained 63 patients suffering from FA and 100 healthy controls. Concentrations of CCL2, CCL5, CCL11, and IgE were measured by enzyme-linked immunosorbent assay (ELISA). Eosinophils were counted using Casy Ι cell counter + analyzer system model SCAREF system GmbH. Differences were considered significant at P < 0.05. Current results showed that FA patients had significantly elevated numbers of circulating periphery eosinophils than the disease-free controls. Serum IgE levels in FA patients were also higher than controls. We also showed that serum levels of CCL2 and CCL11 were significantly enhanced in FA patients compared to control but CCL5 was not detectable. Results of present study revealed that both CCL2 and CCL11 were more elevated in FA children suffering from anaphylaxis and urticaria than bronchial asthma and atopic dermatitis. These results also indicated that more increased levels of CCL2 and CCL11 were observed following consumption of cow's milk and pistachio nuts. Overall, findings of the present study proposed that serum levels of CCL2 and CCL11 are elevated in FA and these may be considered as useful parameters in diagnosis of disorder. It is also possible to design treatments on the basis of blocking of chemokines expression by application of antibodies against them to overcome allergic complications in patients suffering from FA.
authors.affiliation: Department of ENT, Moradi Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Masood
authors.initials: M
authors.lastname: Radman
authors.forename: Gholamhossin
authors.initials: G
authors.lastname: Hassanshahi
authors.forename: Reza
authors.initials: R
authors.lastname: Vazirinejad
authors.forename: Mohammad Kazemi
authors.initials: MK
authors.lastname: Arababadi
authors.forename: Mojgan Noorozi
authors.initials: MN
authors.lastname: Karimabad
authors.forename: Hossein
authors.initials: H
authors.lastname: Khorramdelazad
authors.forename: Houshang
authors.initials: H
authors.lastname: Rafatpanah
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Iranmanesh
authors.forename: Elham
authors.initials: E
authors.lastname: Hakimizadeh
authors.forename: Zahra
authors.initials: Z
authors.lastname: Ahmadi
mesh_terms: D000707:Anaphylaxis / Q000097:blood / Q000276:immunology; D001249:Asthma / Q000097:blood / Q000276:immunology; D054413:Chemokine CCL11 / Q000097:blood*; D018932:Chemokine CCL2 / Q000097:blood*; D018946:Chemokine CCL5 / Q000097:blood*; D002648:Child; D003430:Cross-Sectional Studies; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology; D004804:Eosinophils; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D014581:Urticaria / Q000097:blood / Q000276:immunology
chemical_list: C515456:CCL11 protein, human; C111835:CCL2 protein, human; C483024:CCL5 protein, human; D054413:Chemokine CCL11; D018932:Chemokine CCL2; D018946:Chemokine CCL5; D007073:Immunoglobulin E