title: Iodine-mediated α-acetoxylation of 2,3-disubstituted indoles.
abstract: A new method for direct α-functionalization of 2,3-disubstituted indoles has been developed. The present reaction provides α-acetoxy indole derivatives regioselectively under mild conditions using commercially available and nontoxic iodine reagents. This reaction is a useful synthetic tool because obtained α-acetoxy products can be transformed into various functionalized indoles by substitution reactions with nucleophiles.
authors.affiliation: School of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
authors.forename: Hisaaki
authors.initials: H
authors.lastname: Zaimoku
authors.forename: Takashi
authors.initials: T
authors.lastname: Hatta
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishibashi
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D007455:Iodine