title: Pulmonary perfused blood volume with dual-energy CT as surrogate for pulmonary perfusion assessed with dynamic multidetector CT.
abstract: OBJECTIVE
  To compare measurements of regional pulmonary perfused blood volume (PBV) and pulmonary blood flow (PBF) obtained with computed tomography (CT) in two pig models.
  
  
  METHODS
  The institutional animal care and use committee approved all animal studies. CT-derived PBF and PBV were determined in four anesthetized, mechanically ventilated, supine swine by using two methods for creating pulmonary parenchymal perfusion heterogeneity. Two animals were examined after sequentially moving a pulmonary arterial balloon catheter from a distal to a central location, and two others were examined over a range of static airway pressures, which varied the extents of regional PBF. Lung sections were divided into blocks and Pearson correlation coefficients calculated to compare matching regions between the two methods.
  
  
  RESULTS
  CT-derived PBF, CT-derived PBV, and their associated coefficients of variation (CV) were closely correlated on a region-by-region basis in both the balloon occlusion (Pearson R = 0.91 and 0.73 for animals 1 and 2, respectively; Pearson R = 0.98 and 0.87 for comparison of normalized mean and CV for animals 1 and 2, respectively) and lung inflation studies (Pearson R = 0.94 and 0.74 for animals 3 and 4, respectively; Pearson R = 0.94 and 0.69 for normalized mean and CV for animals 3 and 4, respectively). When accounting for region-based effects, correlations remained highly significant at the P < .001 level.
  
  
  CONCLUSIONS
  CT-derived PBV heterogeneity is a suitable surrogate for CT-derived PBF heterogeneity.
authors.affiliation: Department of Radiology, University of Iowa Carver College of Medicine, 200 Hawkins Dr, CC 701 GH, Iowa City, IA 52241, USA.
authors.forename: Matthew K
authors.initials: MK
authors.lastname: Fuld
authors.forename: Ahmed F
authors.initials: AF
authors.lastname: Halaweish
authors.forename: Susan E
authors.initials: SE
authors.lastname: Haynes
authors.forename: Abhay A
authors.initials: AA
authors.lastname: Divekar
authors.forename: Junfeng
authors.initials: J
authors.lastname: Guo
authors.forename: Eric A
authors.initials: EA
authors.lastname: Hoffman
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology*; D003287:Contrast Media / Q000008:administration & dosage; D007479:Iopamidol / Q000008:administration & dosage; D008168:Lung / Q000098:blood supply* / Q000000981:diagnostic imaging*; D023421:Models, Animal; D061330:Multidetector Computed Tomography / Q000379:methods*; D013552:Swine
chemical_list: D003287:Contrast Media; D007479:Iopamidol