title: Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.
abstract: Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in Cancer (GDSC) database (www.cancerRxgene.org) is the largest public resource for information on drug sensitivity in cancer cells and molecular markers of drug response. Data are freely available without restriction. GDSC currently contains drug sensitivity data for almost 75 000 experiments, describing response to 138 anticancer drugs across almost 700 cancer cell lines. To identify molecular markers of drug response, cell line drug sensitivity data are integrated with large genomic datasets obtained from the Catalogue of Somatic Mutations in Cancer database, including information on somatic mutations in cancer genes, gene amplification and deletion, tissue type and transcriptional data. Analysis of GDSC data is through a web portal focused on identifying molecular biomarkers of drug sensitivity based on queries of specific anticancer drugs or cancer genes. Graphical representations of the data are used throughout with links to related resources and all datasets are fully downloadable. GDSC provides a unique resource incorporating large drug sensitivity and genomic datasets to facilitate the discovery of new therapeutic biomarkers for cancer therapies.
authors.affiliation: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
authors.forename: Wanjuan
authors.initials: W
authors.lastname: Yang
authors.forename: Jorge
authors.initials: J
authors.lastname: Soares
authors.forename: Patricia
authors.initials: P
authors.lastname: Greninger
authors.forename: Elena J
authors.initials: EJ
authors.lastname: Edelman
authors.forename: Howard
authors.initials: H
authors.lastname: Lightfoot
authors.forename: Simon
authors.initials: S
authors.lastname: Forbes
authors.forename: Nidhi
authors.initials: N
authors.lastname: Bindal
authors.forename: Dave
authors.initials: D
authors.lastname: Beare
authors.forename: James A
authors.initials: JA
authors.lastname: Smith
authors.forename: I Richard
authors.initials: IR
authors.lastname: Thompson
authors.forename: Sridhar
authors.initials: S
authors.lastname: Ramaswamy
authors.forename: P Andrew
authors.initials: PA
authors.lastname: Futreal
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Haber
authors.forename: Michael R
authors.initials: MR
authors.lastname: Stratton
authors.forename: Cyril
authors.initials: C
authors.lastname: Benes
authors.forename: Ultan
authors.initials: U
authors.lastname: McDermott
authors.forename: Mathew J
authors.initials: MJ
authors.lastname: Garnett
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003196:Computer Graphics; D030541:Databases, Genetic; D052138:Genes, Neoplasm; D005819:Genetic Markers; D023281:Genomics; D006801:Humans; D020407:Internet; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D005819:Genetic Markers