title: [Space flight/bedrest immobilization and bone. Space flight and bed rest-mediated muscle atrophy].
abstract: Muscle atrophy caused by unloading stress is a challenging problem for bed-rested patients or astronauts. However, countermeasures against these muscle atrophy have not been developed yet. Under unloading conditions, skeletal muscle mass is rapidly lost by the increase in protein breakdown and the decrease in protein synthesis. It has been shown that this enhancement of proteolysis in atrophying muscles results mainly from activation of the ubiquitin-proteasome proteolytic pathway. Previous our studies revealed that unloading stress led to skeletal muscle atrophy through the induction of ubiquitin ligase, Cbl-b (Casitas B-lineage lymphoma b) expression. Thus, Cbl-b inhibiters may be potent therapeutic and preventive sources against skeletal muscle atrophy caused by unloading stress.
authors.affiliation: Department of Nutritional Physioloy, Institute of Health Biosciences, University of Tokushima Graduate School, Japan.
authors.forename: Chika
authors.initials: C
authors.lastname: Ikeda
authors.forename: Tomoki
authors.initials: T
authors.lastname: Abe
authors.forename: Atsuko
authors.initials: A
authors.lastname: Sakai
authors.forename: Katsuya
authors.initials: K
authors.lastname: Hirasaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nikawa
mesh_terms: D001510:Bed Rest / Q000009:adverse effects*; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D007103:Immobilization / Q000009:adverse effects; D018482:Muscle, Skeletal / Q000378:metabolism*; D009133:Muscular Atrophy / Q000209:etiology / Q000378:metabolism*; D013026:Space Flight