title: New furanones from the plant endophytic fungus Pestalotiopsis besseyi.
abstract: Pestalafuranones A-E (compounds 1-5), five new 2(5H)-furanones, have been isolated from cultures of an isolate of Pestalotiopsis besseyi. The structures of these compounds were elucidated mainly by analysis of their NMR spectroscopic data and HRESIMS experiments. Pestalafuranones A-C (compounds 1-3) displayed weak inhibitory effects against HIV-1 replication in C8166 cells, whereas pestalafuranones D (4) and E (5) showed moderate antifungal activity against the plant pathogens Verticillium dahiae and Alternaria longipes.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Liu
authors.forename: Shuchun
authors.initials: S
authors.lastname: Liu
authors.forename: Liangdong
authors.initials: L
authors.lastname: Guo
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Langjun
authors.initials: L
authors.lastname: Cui
authors.forename: Gang
authors.initials: G
authors.lastname: Ding
mesh_terms: D000528:Alternaria / Q000187:drug effects; D019380:Anti-HIV Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry / Q000187:drug effects / Q000382:microbiology; D020172:Verticillium / Q000187:drug effects; D013098:Xylariales / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D000935:Antifungal Agents; D005663:Furans