title: Electroresponsive polymer-carbon nanotube hydrogel hybrids for pulsatile drug delivery in vivo.
abstract: Drug release triggered by an external non-invasive stimulus is of great interest for the development of new drug delivery systems. The preparation of an electroresponsive multiwalled carbon nanotube/poly(methylacrylic acid) (MWNT/PMAA)-based hybrid material is reported. The hydrogel hybrids achieve a controlled drug release upon the ON/OFF application of an electric field, giving rise to in vitro and in vivo pulsatile release profiles.
authors.affiliation: Nanomedicine Lab, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Ania
authors.initials: A
authors.lastname: Servant
authors.forename: Laura
authors.initials: L
authors.lastname: Methven
authors.forename: Rhodri P
authors.initials: RP
authors.lastname: Williams
authors.forename: Kostas
authors.initials: K
authors.lastname: Kostarelos
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000528:radiation effects; D004574:Electromagnetic Fields; D020100:Hydrogels / Q000737:chemistry* / Q000528:radiation effects; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000528:radiation effects; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000528:radiation effects; D011109:Polymethacrylic Acids / Q000737:chemistry* / Q000528:radiation effects; D011829:Radiation Dosage
chemical_list: D003692:Delayed-Action Preparations; D020100:Hydrogels; D053769:Nanocapsules; D037742:Nanotubes, Carbon; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid