title: The novel insulin resistance parameters RBP4 and GLP-1 in patients treated with valproic acid: just a sidestep?
abstract: Valproic acid (VPA), as one of the most widely prescribed antiepileptic drugs (AED) for many types of epilepsy in adults and children, is associated with weight gain, alteration of adipocytokine homeostasis, insulin resistance and Non-Alcoholic Fatty Liver Disease (NAFLD). Retinol-binding protein 4 (RBP4) and Glucagon-like peptide-1 (GLP-1) are considered as important new targets in modern type 2 diabetes mellitus therapy linked to insulin resistance, NAFLD and visceral obesity acting via peripheral or central mechanisms. We herein demonstrate the lack of an influence of VPA treatment on RBP4 and GLP-1 in otherwise healthy patients. In summary, the absence of any relationship with RBP4 and GLP-1 concentrations does not suggest a role of these novel insulin resistance parameters as potential regulators of glucose and fat metabolism during VPA-therapy.
authors.affiliation: Department of Pediatrics, Saint Vincent Hospital Zams, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Rauchenzauner
authors.forename: M
authors.initials: M
authors.lastname: Laimer
authors.forename: M
authors.initials: M
authors.lastname: Wiedmann
authors.forename: A
authors.initials: A
authors.lastname: Tschoner
authors.forename: K
authors.initials: K
authors.lastname: Salzmann
authors.forename: W
authors.initials: W
authors.lastname: Sturm
authors.forename: A
authors.initials: A
authors.lastname: Sandhofer
authors.forename: G
authors.initials: G
authors.lastname: Walser
authors.forename: G
authors.initials: G
authors.lastname: Luef
authors.forename: C F
authors.initials: CF
authors.lastname: Ebenbichler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000494:pharmacology*; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005234:Fatty Liver / Q000188:drug therapy; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*; D014635:Valproic Acid / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D014635:Valproic Acid; D052216:Glucagon-Like Peptide 1; D005947:Glucose