title: Serum coenzyme Q10 levels are associated with coronary flow reserve in hemodialysis patients.
abstract: Accelerated atherosclerosis is the major cause of mortality in patients on chronic hemodialysis (HD). The aim of this study was to evaluate the relation between coenzyme Q10 (CoQ10) levels and coronary flow reserve (CFR) in HD patients as an indicator of atherosclerosis. Seventy-one chronic HD patients and 65 age- and sex-matched healthy individuals were included in the study. Plasma CoQ10 levels were performed by high-performance liquid chromatography measurements. CFR was assessed by transthoracic Doppler echocardiography. Serum CoQ10 levels (1.36 ± 0.43 vs. 2.53 ± 0.55, P < 0.001) and CFR values (1.73 ± 0.11 vs. 2.32 ± 0.28, P < 0.001) were significantly lower in HD patients compared with controls. There was a significant positive correlation between CFR and serum levels of CoQ10 (r = 0.669, P < 0.001). A linear regression analysis showed that serum levels of CoQ10 were still significantly and positively correlated with CFR (regression coefficient = 0.235, P < 0.001). Our data have demonstrated that HD patients exhibit decreased plasma CoQ10 levels and CFR values. The study also showed for the first time that serum CoQ10 levels independently predict CFR in HD patients.
authors.affiliation: Department of Nephrology, Uskudar State Hospital, İstanbul, Turkey. beyzamacunlu@hotmail.com
authors.forename: Beyza
authors.initials: B
authors.lastname: Macunluoglu
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Kaya
authors.forename: Aydin
authors.initials: A
authors.lastname: Atakan
authors.forename: Elif
authors.initials: E
authors.lastname: Ari
authors.forename: Cigdem
authors.initials: C
authors.lastname: Kaspar
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
authors.forename: Hamit Hakan
authors.initials: HH
authors.lastname: Alp
authors.forename: Ebru
authors.initials: E
authors.lastname: Asicioglu
authors.forename: Alla Eldeen
authors.initials: AE
authors.lastname: Kedrah
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D014463:Ultrasonography
chemical_list: D014451:Ubiquinone; C024989:coenzyme Q10