title: The effects of local nitroglycerin on the surgical delay procedure in prefabricated flaps by vascular implant in rats.
abstract: OBJECTIVE
  To evaluate the effect of local nitroglycerin on the viable area of a prefabricated flap for vascular implant in rats, and to investigate the surgical delay procedure.
  
  
  METHODS
  A femoral pedicle was implanted under the skin of the abdominal wall in forty Wistar rats. The animals were divided into four groups of ten: group 1 - without surgical delay procedure and local nitroglycerin; group 2 - with surgical delay procedure, but without local nitroglycerin; group 3 - without surgical delay procedure, but with local nitroglycerin; and group 4 - with simultaneous surgical delay procedure and local nitroglycerin. The percentages of the viable areas, in relation to the total flap, were calculated using AutoCAD R 14.
  
  
  RESULTS
  The mean percentage value of the viable area was 8.9% in the group 1. 49.4% in the group 2; 8.4% in the group 3 and 1.1% in the group 4. There was significant difference between groups 1 and 2 (p=0.005), 1 and 4 (p=0.024), 2 and 3 (p=0.003), 2 and 4 (p=0.001). These results support the hypothesis that the closure of the arterial venous channels is responsible for the phenomenon of surgical delay procedure.
  
  
  CONCLUSIONS
  Local nitroglycerin did not cause an increase in the prefabricated viable flap area by vascular implantation and decreased the viable flap area that underwent delay procedures.
authors.affiliation: UFPE, Recife, PE, Brazil. jzacche@surfix.com.br
authors.forename: Jairo Zacchê de
authors.initials: JZ
authors.lastname: Sá
authors.forename: José Lamartine de Andrade
authors.initials: JL
authors.lastname: Aguiar
authors.forename: Adriana Ferreira
authors.initials: AF
authors.lastname: Cruz
authors.forename: Alexandre Ricardo Pereira
authors.initials: AR
authors.lastname: Schuler
authors.forename: José Ricardo Alves de
authors.initials: JR
authors.lastname: Lima
authors.forename: Olga Martins
authors.initials: OM
authors.lastname: Marques
mesh_terms: D000009:Abdominal Muscles / Q000601:surgery*; D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D006085:Graft Survival / Q000187:drug effects; D008297:Male; D023421:Models, Animal; D005996:Nitroglycerin / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013524:Surgical Flaps / Q000098:blood supply* / Q000473:pathology; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin