title: [Anti-SRP myopathy: different entity from myositis].
abstract: Anti-signal recognition particle (SRP) antibody, detected in 5-8% of patients with clinical diagnosis of myositis, had been associated with severe and refractory myositis. However, it has been accepted that anti-SRP myopathy should be separated from myositis based on histological features of necrotizing myopathy. We reviewed clinical features of 27 patients with anti-SRP myopathy, and analyzed disease progression and neurological outcome. Anti-SRP antibodies in serum were detected by RNA immunoprecipitation assay using extracts of K562 cells. Of the 27 patients, 5 (18.5%) showed chronic progressive muscle weakness as well as atrophy of limbs and trunk muscles from a younger age with more severe neurological outcomes compared to the other 22 patients with the subacute form. A subset of patients with anti-SRP myopathy can show a chronic progressive form associated with severe clinical deficits.
authors.affiliation: Department of Neurology, Keio University School of Medicine.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Suzuki
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D009135:Muscular Diseases / Q000473:pathology*; D009220:Myositis / Q000473:pathology; D018271:Signal Recognition Particle / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D018271:Signal Recognition Particle