title: Adipokine levels in the course of mild biliary pancreatitis.
abstract: OBJECTIVE
  Obesity markedly increases the risk of severe acute pancreatitis (AP). Several adipokines have been ascribed a role as a predictor of clinical severity in AP. Therefore, the aim of this study was to investigate a possible relationship between leptin and adiponectin and mild biliary AP.
  
  
  METHODS
  We included 24 consecutive patients with mild biliary AP and 24 consecutive healthy age- and sex-matched controls. Clinical severity was classified by the Ranson score. ELISA was used to assess leptin and adiponectin levels on admission and in remission. Complete blood cell counts and other laboratory tests were also performed at baseline and in remission.
  
  
  RESULTS
  Leptin, adiponectin, insulin and HOMA-IR measurements showed no difference in pancreatitis patients both on admission and in remission compared to the control group. No difference was found in leptin, insulin or HOMA-IR levels in the course of pancreatitis. However, adiponectin levels were higher in remission compared to admission.
  
  
  CONCLUSIONS
  Increased adiponectin levels in remission may be an indication of improvement in this condition. Further studies are needed to determine whether adiponectin provides protection from AP.
authors.affiliation: Department of Internal Medicine, Ankara Education and Research Hospital, Ministry of Health, Ankara, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Demirci
authors.forename: Erdem
authors.initials: E
authors.lastname: Akbal
authors.forename: Erdem
authors.initials: E
authors.lastname: Koçak
authors.forename: Adnan
authors.initials: A
authors.lastname: Taş
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Köklü
mesh_terms: D000208:Acute Disease; D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology; D010195:Pancreatitis / Q000097:blood* / Q000209:etiology / Q000503:physiopathology*
chemical_list: D052242:Adiponectin; D007328:Insulin; D020738:Leptin