title: [Pro-inflammatory cytokines related to severity and mortality in type 2 diabetes patients with soft tissue infection].
abstract: OBJECTIVE
  to determine the relation between IL6, IL10 and TNFa serum levels in a cohort of patients with type 2 diabetes (T2D) and severe soft tissue infections (STI), with severity and mortality factors.
  
  
  METHODS
  A. comparative and transversal, study with 15 adult patients, any gender, with T2D and STI were done. A T2D control group of 20 patients without STI was included. Apache II Score, glycemia and by ELISA, IL6, IL10 and TNFa, were determined.
  
  
  RESULTS
  in all patients, it was a correlation at beginning between glycemia and IL6 (r = 0.67, IC 95 % 0.24-0.88), as soon as glycemia and Apache II, (r = 0.59, IC 95 % 0.11-0.83).
  
  
  CONCLUSIONS
  although IL6 was very usefulness, it is not a routine test in clinical laboratory and it is expensive, but in medical practice, it could be possible to evaluate these patients with Apache II Score and glycemia. However, in STI, the values of IL6 and IL10 were highly significant. It is likely that IL6 is a marker of poor outcome.
authors.affiliation: Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Distrito Federal, México. gelorriaga@webtelmex.net.mx
authors.forename: Guadalupe
authors.initials: G
authors.lastname: García-Elorriaga
authors.forename: Miguel
authors.initials: M
authors.lastname: Padilla-Reyes
authors.forename: Francisco
authors.initials: F
authors.lastname: Cruz-Olivo
authors.forename: José Luis
authors.initials: JL
authors.lastname: Fuentes-Allen
authors.forename: Guillermo
authors.initials: G
authors.lastname: del Rey-Pineda
authors.forename: César
authors.initials: C
authors.lastname: González-Bonilla
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000097:blood* / Q000401:mortality*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000401:mortality*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D018461:Soft Tissue Infections / Q000097:blood* / Q000150:complications / Q000401:mortality*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10