title: Antibody-targeted drug delivery to injured arteries using layered double hydroxide nanoparticles.
abstract: Targeted local delivery of a nanoparticle-based, antibody-targeted, and low molecular weight heparin (LMWH) delivery system successfully reduces restenosis and thrombus formation in an animal model. An antibody recognizing cross-linked fibrin (XLF) D-dimer is successfully conjugated to layered double hydroxide nanoparticles. Use of the anti-XLF-conjugated LMWH-carrying layered double hydroxide nanoparticles shows successful targeting of the nanoparticles (red) to the injured artery wall (green), resulting in decreased neointimal thickening and thrombus formation.
authors.affiliation: ARC Centre of Excellence for Functional Nanomaterials, Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: Zi
authors.initials: Z
authors.lastname: Gu
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Rolfe
authors.forename: Zhi Ping
authors.initials: ZP
authors.lastname: Xu
authors.forename: Julie H
authors.initials: JH
authors.lastname: Campbell
authors.forename: G Q Max
authors.initials: GQ
authors.lastname: Lu
authors.forename: Anita C
authors.initials: AC
authors.lastname: Thomas
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D020212:Carotid Artery Injuries / Q000188:drug therapy* / Q000473:pathology*; D006878:Hydroxides / Q000737:chemistry*; D008297:Male; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D006878:Hydroxides; D053769:Nanocapsules