title: Effects of aerobic training on exercise-related oxidative stress in mitochondrial myopathies.
abstract: In mitochondrial myopathies with respiratory chain deficiency impairment of energy cell production may lead to in excess reactive oxygen species generation with consequent oxidative stress and cell damage. Aerobic training has been showed to increase muscle performance in patients with mitochondrial myopathies. Aim of this study has been to evaluate, in 7 patients (6 F e 1M, mean age 44.9 ± 12.1 years) affected by mitochondrial disease, concomitantly to lactate exercise curve, the occurrence of oxidative stress, as indicated by circulating levels of lipoperoxides, in rest condition and as effect of exercise, and also, to verify if an aerobic training program is able to modify, in these patients, ox-redox balance efficiency. At rest and before training blood level of lipoperoxides was 382.4 ± 37.8 AU, compared to controls (318.7 ± 63.8; P<0.05), this corresponding to a moderate oxidative stress degree according to the adopted scale. During incremental exercise blood level of lipoperoxides did not increase, but maintained significantly higher compared to controls. After an aerobic training of 10 weeks the blood level of lipoperoxides decreased by 13.7% at rest (P<0.01) and 10.4%, 8.6% and 8.5% respectively at the corresponding times during the exercise test (P=0.06). These data indicate that, in mitochondrial patients, oxidative stress occurs and that an aerobic training is useful in partially reverting this condition.
authors.affiliation: Department of Neuroscience, University of Pisa, Pisa, Italy. g.siciliano@med.unipi.it
authors.forename: Gabriele
authors.initials: G
authors.lastname: Siciliano
authors.forename: Costanza
authors.initials: C
authors.lastname: Simoncini
authors.forename: Annalisa
authors.initials: A
authors.lastname: Lo Gerfo
authors.forename: Daniele
authors.initials: D
authors.lastname: Orsucci
authors.forename: Giulia
authors.initials: G
authors.lastname: Ricci
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Mancuso
mesh_terms: D000328:Adult; D015444:Exercise; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism; D017240:Mitochondrial Myopathies / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D018384:Oxidative Stress; D010101:Oxygen Consumption; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D008054:Lipid Peroxides; D017382:Reactive Oxygen Species