title: Molecular targeted therapy in lung cancer.
abstract: Genetic sequencing has allowed better understanding of non-small-cell lung cancer, leading to improvements in the ability to diagnose and treat the disease through targeted therapy. This article describes some of the past and ongoing studies of targeted therapies for lung cancers, the genetic mutations in lung cancers that develop in people who never smoked, and the role of Minnesota researchers in understanding the pathogenesis of lung cancer.
authors.affiliation: Department of Medicine, Masonic Cancer Center, University of Minnesota, USA.
authors.forename: Naomi
authors.initials: N
authors.lastname: Fujioka
authors.forename: Peter B
authors.initials: PB
authors.lastname: Bitterman
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000639:trends; D005544:Forecasting; D018740:Genetic Heterogeneity; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D008910:Minnesota; D058990:Molecular Targeted Therapy / Q000639:trends*; D017422:Sequence Analysis, DNA / Q000639:trends*; D012907:Smoking / Q000009:adverse effects / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor