title: Recently introduced foods as new allergenic sources: sensitisation to Goji berries (Lycium barbarum).
abstract: Goji berries (GB) have been introduced in Western diet. Preliminary reports have demonstrated its allergenic capacity. The objectives of the study were to investigate the frequency of sensitisation and the allergens involved. 566 individuals, with respiratory or cutaneous symptoms were skin-prick tested with GB extract. Thirty three were positive (5.8%). 94% were sensitised to other allergens. Specific IgE to GB, peach, tomato and nut-mix was measured. Thirteen individuals from 24 available sera (54.2%) had positive specific IgE. 92.3% of GB positive patients were positive to peach. Seven individuals recognised 8 bands and six recognised a 7kDa band. This band was identified as a LTP by MS/MS. Cross-reactivity was demonstrated with tomato, tobacco, nutmix, Artemisia pollen and purified Lyc e 3 and Pru p 3. GB are a new allergenic source with high prevalence of sensitisation. LTP seems to be the major allergen involved in sensitisation and cross-reactivity.
authors.affiliation: Research & Development, Laboratorios LETI S.L., Calle del Sol 5, 28760 Tres Cantos, Madrid, Spain. jcarnes@leti.com
authors.forename: Jerónimo
authors.initials: J
authors.lastname: Carnés
authors.forename: Carlos H
authors.initials: CH
authors.lastname: de Larramendi
authors.forename: Angel
authors.initials: A
authors.lastname: Ferrer
authors.forename: Angel Julio
authors.initials: AJ
authors.lastname: Huertas
authors.forename: María Angeles
authors.initials: MA
authors.lastname: López-Matas
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Pagán
authors.forename: Luis Angel
authors.initials: LA
authors.lastname: Navarro
authors.forename: José Luis
authors.initials: JL
authors.lastname: García-Abujeta
authors.forename: Sandra
authors.initials: S
authors.lastname: Vicario
authors.forename: Maribel
authors.initials: M
authors.lastname: Peña
mesh_terms: D000293:Adolescent; D000328:Adult; D052179:Antigens, Plant / Q000276:immunology*; D003429:Cross Reactions; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007073:Immunoglobulin E / Q000276:immunology; D032305:Lycium / Q000737:chemistry / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D052179:Antigens, Plant; D007073:Immunoglobulin E