title: [Stress and auto-immunity].
abstract: The etiology of auto-immune disorders is multifactorial. Stress is probably a participating factor. Indeed, a high proportion of patients with auto-immune diseases report uncommon stress before disease onset or disease flare. The biological consequences of stress are increasingly well understood. Glucocorticoids and catecholamines released by hypothalamic-pituitary-adrenal axis during stress will alter the balance Th1/Th2 and the balance Th17/Treg. Stress impairs cellular immunity, decreases immune tolerance and stimulates humoral immunity exposing individuals to autoimmune disease among others. The treatment for autoimmune disease should include stress management.
authors.affiliation: Service de médecine interne, CHU de Clermont-Ferrand, 58 rue Montalembert, Clermont-Ferrand cedex 1, France. idelevaux@chu-clermontferrand.fr
authors.forename: I
authors.initials: I
authors.lastname: Delévaux
authors.forename: A
authors.initials: A
authors.lastname: Chamoux
authors.forename: O
authors.initials: O
authors.lastname: Aumaître
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology; D015551:Autoimmunity / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000502:physiology; D009490:Neurosecretory Systems / Q000502:physiology; D013315:Stress, Psychological / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000502:physiology