title: Epidemiological study of fixed drug eruption in Pointe-Noire.
abstract: A prospective study was conducted over a 27 month period in order to determine the epidemiological profile of fixed drug eruption (FDE) observed during a dermatological consultation at Pointe-Noire. During the study period 54 out of 9,070 persons consulting (0.6%) suffered from clinically diagnosed FDE. The variables studied were: age, sex, medicine and point of sale. The average age of onset was 30 years. The frequency of onset was higher in males (38 patients) than in females (16 patients). The incriminated medicines were: the sulfamides (48 patients) including Cotrimoxazole (45 patients ) and Sulfadoxine and Pyremethamine (3 patients) Coartem(®) + Doliprane(®) (1 patient), Chloramphenicol(®) (1 patient), Amidol(®) (1 patient), Duocotexin(®) + Paracetamol(®) (1 patient), Surquina(®) (1 patient), Amodiaquine(®) (1 patient). The point of sale was illicit (peddlers, markets) for 44 patients; for 10 patients it was a lawful outlet (pharmacies). This study shows that cotrimoxazole bought at illicit points of sale is the main etiology of FDE in the department, confirming that these medicines are counterfeit. The involvement of dermatologists in the fight against the illicit sale of medicines should be made a priority.
authors.affiliation: Regional Hospital of the Armed Forces, Pointe-Noire, Congo. onognongoibiaho@yahoo.fr
authors.forename: A N
authors.initials: AN
authors.lastname: Ognongo-Ibiaho
authors.forename: H L
authors.initials: HL
authors.lastname: Atanda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003223:Congo / Q000453:epidemiology; D058110:Counterfeit Drugs / Q000009:adverse effects*; D003875:Drug Eruptions / Q000453:epidemiology*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011203:Poverty; D011446:Prospective Studies; D012867:Skin / Q000187:drug effects*; D013420:Sulfamethoxazole / Q000009:adverse effects; D014295:Trimethoprim / Q000009:adverse effects; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D058110:Counterfeit Drugs; D014295:Trimethoprim; D013420:Sulfamethoxazole