title: Evaluation of the sedative and hypnotic effects of Eucommiol in Eucommia.
abstract: The purpose of this study was to evaluate the sedative and hypnotic effects of Eucommiol, a monomer compound extracted from male Eucommia flowers using a system solvent method. Eucommiol shows significant effects in mice, including reduced spontaneous activity, and increased the sleep ratio or lengthened the sleep time with a subthreshold or superthreshold dose of pentobarbital sodium, respectively. In addition, could effectively shorten sleep latency, reduce convulsion rate and prolong convulsion latency. These findings intensely indicated that Eucommiol has excellent sedative and hypnotic effects.
authors.affiliation: a College of Food and Bioengineering , Henan University of Science and Technology , Luoyang , 471003 , China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Wenxue
authors.initials: W
authors.lastname: Zhu
authors.forename: Lipeng
authors.initials: L
authors.lastname: Yang
authors.forename: Dongqing
authors.initials: D
authors.lastname: Fei
authors.forename: Jinling
authors.initials: J
authors.lastname: Fan
authors.forename: Lin
authors.initials: L
authors.lastname: Du
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000438:Alcohols / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000494:pharmacology*; D003517:Cyclopentanes / Q000737:chemistry* / Q000494:pharmacology*; D031283:Eucommiaceae / Q000737:chemistry*; D006993:Hypnotics and Sedatives / Q000737:chemistry* / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
chemical_list: D000438:Alcohols; D000927:Anticonvulsants; D003517:Cyclopentanes; D006993:Hypnotics and Sedatives; C406682:eucommiol; D010424:Pentobarbital