title: Regulation of Ras signal transduction during T cell development and activation.
abstract: T cell receptor-induced activation of the Ras signaling pathway is essential for T cell development, proliferation and differentiation. Given the central role of Ras in T cell biology its activation must be tightly regulated. However, precisely how Ras activation is controlled in T cells is not completely understood. In this review, we provide a summary of the known factors and mechanisms involved in positive and negative regulation of Ras activation in the T cell lineage.
authors.affiliation: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Philip E
authors.initials: PE
authors.lastname: Lapinski
authors.forename: Philip D
authors.initials: PD
authors.lastname: King