title: A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis.
abstract: Cell cycle transitions are driven by the periodic oscillations of cyclins, which bind and activate cyclin-dependent kinases (CDKs) to phosphorylate target substrates. Cyclin F uses a substrate recruitment strategy similar to that of the other cyclins, but its associated catalytic activity is substantially different. Indeed, cyclin F is the founding member of the F-box family of proteins, which are the substrate recognition subunits of Skp1-Cul1-F-box protein (SCF) ubiquitin ligase complexes. Here, we discuss cyclin F function and recently identified substrates of SCF(cyclin)(F) involved in deoxyribonucleotide triphosphate (dNTP) production, centrosome duplication, and spindle formation. We highlight the relevance of cyclin F in controlling genome stability through ubiquitin-mediated proteolysis and the implications for cancer development.
authors.affiliation: Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA. vincenzo.d'angiolella@nyumc.org
authors.forename: Vincenzo
authors.initials: V
authors.lastname: D'Angiolella
authors.forename: Mine
authors.initials: M
authors.lastname: Esencay
authors.forename: Michele
authors.initials: M
authors.lastname: Pagano
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D016213:Cyclins / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D015894:Genome, Human; D042822:Genomic Instability; D006801:Humans; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D059748:Proteolysis; D012262:Ribonucleoside Diphosphate Reductase / Q000235:genetics / Q000378:metabolism; D044843:SKP Cullin F-Box Protein Ligases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D025801:Ubiquitin / Q000235:genetics* / Q000378:metabolism
chemical_list: C503669:CCNF protein, human; D016213:Cyclins; D021122:Protein Subunits; D025801:Ubiquitin; C093713:ribonucleotide reductase M2; D012262:Ribonucleoside Diphosphate Reductase; D044843:SKP Cullin F-Box Protein Ligases