title: Changes in volumetric BMD of radius and tibia upon antidepressant drug administration in young depressive patients.
abstract: OBJECTIVE
  To determine longitudinal changes in trabecular volumetric BMD (vBMD) at tibia and radius in young depressive patients under antidepressants using pQCT.
  
  
  METHODS
  PQCT data on 26 patients (22 females, 4 males) on serotonin re-uptake inhibitors (SSRI), and 14 patients (12 females, 2 males) on non-SSRI (10 SNRI, 4 TCA) were obtained at 4% and 66% of radius and tibia at baseline and at 12-month. Depression was assessed by Beck Depression Inventory (BDI) at baseline and follow-up. Wilcoxon tests were performed to find longitudinal changes in bone parameters within each group, Mann-Whitney tests to detect differences between groups.
  
  
  RESULTS
  The two groups were comparable with regard to age, height and BDI. None of the measured bone parameters changed in the SSRI group. In the non-SSRI group trabecular vBMD increased slightly but significantly from baseline to follow-up at radius and tibia (p<0.03). Between group differences were significant for trabecular BMD at the radius. BDI decreased significantly in both groups by the same amount.
  
  
  CONCLUSIONS
  Bone properties were found to be stable over 12 months under therapy with SSRIs. Whether SNRI and TCA indeed increase trabecular vBMD need to be shown in larger cohort.
authors.affiliation: Department of Rheumatology and Clinical Immunology/Allergology, Inselspital Bern, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Winterhalder
authors.forename: P
authors.initials: P
authors.lastname: Eser
authors.forename: J
authors.initials: J
authors.lastname: Widmer
authors.forename: P M
authors.initials: PM
authors.lastname: Villiger
authors.forename: D
authors.initials: D
authors.lastname: Aeberli
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015519:Bone Density / Q000187:drug effects*; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011859:Radiography; D011884:Radius / Q000000981:diagnostic imaging / Q000187:drug effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013977:Tibia / Q000000981:diagnostic imaging / Q000187:drug effects*
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors