title: Interactions of the GnRH receptor with heterotrimeric G proteins.
abstract: G protein-coupled receptors (GPCRs) are the largest class of integral membrane protein receptors in the human genome. We examined here the reports whether the GnRH receptor (GnRHR) interacts with a single or multiple types of G proteins. It seems that the GnRHR, as other GPCRs, alternates between various conformations and is stabilized by its ligands, other modulators and intracellular partners in selective conformations culminating in coupling with a single type or multiple G proteins in a cell- and context-specific manner.
authors.affiliation: Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel. zvin@tauex.tau.ac.il
authors.forename: Zvi
authors.initials: Z
authors.lastname: Naor
authors.forename: Ilpo
authors.initials: I
authors.lastname: Huhtaniemi
mesh_terms: D000494:Allosteric Regulation / Q000502:physiology; D000818:Animals; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D054799:Phospholipase C beta / Q000378:metabolism; D010902:Pituitary Gland / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D011966:Receptors, LHRH / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D008565:Membrane Proteins; D043562:Receptors, G-Protein-Coupled; D011966:Receptors, LHRH; D054799:Phospholipase C beta; D020962:Heterotrimeric GTP-Binding Proteins