title: From in situ to in vivo: an in situ click-chemistry-derived carbonic anhydrase II imaging agent for positron emission tomography.
abstract: CA II makes a good PET: Discovering positron emission tomography (PET) probes with high target affinities is challenging. PET probe discovery using in situ click chemistry uses (19) F-bearing fragments as (18) F surrogates. This ensures that the lead hits and PET probes have equivalent chemical or biological characteristics, making PET probe discovery predictable and reliable.
authors.affiliation: Siemens Molecular Imaging Biomarker Research, 6100 Bristol Parkway, Culver City, CA 90230, USA.
authors.forename: Vani P
authors.initials: VP
authors.lastname: Mocharla
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Walsh
authors.forename: Henry C
authors.initials: HC
authors.lastname: Padgett
authors.forename: Helen
authors.initials: H
authors.lastname: Su
authors.forename: Barbara
authors.initials: B
authors.lastname: Fueger
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Weber
authors.forename: Johannes
authors.initials: J
authors.lastname: Czernin
authors.forename: Hartmuth C
authors.initials: HC
authors.lastname: Kolb
mesh_terms: D000818:Animals; D024402:Carbonic Anhydrase II / Q000032:analysis*; D057930:Click Chemistry / Q000379:methods*; D004912:Erythrocytes / Q000201:enzymology; D005462:Fluorine Radioisotopes / Q000032:analysis*; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D005462:Fluorine Radioisotopes; D024402:Carbonic Anhydrase II