title: The effects of opiate consumption on serum reproductive hormone levels, sperm parameters, seminal plasma antioxidant capacity and sperm DNA integrity.
abstract: We evaluated the effects of opiate consumption on semen quality, sperm function, seminal plasma antioxidant capacity, and sperm DNA integrity. A total of 142 opiate addict men (group 1) were enrolled in the study and 146 healthy age matched male volunteers (group 2) served as controls. Two semen analyses were performed in all participants. Sperm chromatin structure assay (SCSA) was used to identify sperm DNA integrity. The mean±SD sperm concentration in opiate users and in control subjects was 22.2±4.4 and 66.3±8.3 million per ml, respectively (P=0.002). A significant increase in the amount of fragmented DNA was found in opiate consumers compared with that in controls (36.4±3.8% vs. 27.1±2.4%, P=0.004). Significantly decreased levels of catalase-like and superoxide dismutase-like (SOD) activity were observed in group 1 compared with group 2. Opiate consumption has significant adverse effects on semen quality. In cases of unexplained infertility in men, opium consumption should be considered as a possible factor.
authors.affiliation: Clinical Center for Urological Disease Diagnosis and Private Clinic Specialized in Urological and Andrological Genetics, Tehran, Iran. info@safarinejad.com
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Safarinejad
authors.forename: Seyyed Alaeddin
authors.initials: SA
authors.lastname: Asgari
authors.forename: Alireza
authors.initials: A
authors.lastname: Farshi
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Ghaedi
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Kolahi
authors.forename: Shahrokh
authors.initials: S
authors.lastname: Iravani
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Khoshdel
mesh_terms: D020101:Acrosome Reaction / Q000187:drug effects; D000328:Adult; D000701:Analgesics, Opioid / Q000493:pharmacokinetics / Q000633:toxicity* / Q000652:urine; D016022:Case-Control Studies; D002843:Chromatin / Q000737:chemistry / Q000187:drug effects; D004249:DNA Damage; D039721:Diagnostic and Statistical Manual of Mental Disorders; D012739:Gonadal Steroid Hormones / Q000037:antagonists & inhibitors / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000037:antagonists & inhibitors / Q000097:blood; D006213:Hallucinogens / Q000493:pharmacokinetics / Q000633:toxicity / Q000652:urine; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D010088:Oxidoreductases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012661:Semen / Q000737:chemistry / Q000187:drug effects* / Q000201:enzymology; D013094:Spermatozoa / Q000187:drug effects*; D015813:Substance Abuse Detection; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D002843:Chromatin; D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D006213:Hallucinogens; D010088:Oxidoreductases