title: Antidepressant-like effects of lobeline in mice: behavioral, neurochemical, and neuroendocrine evidence.
abstract: Preclinical and clinical studies suggest that neuronal nicotinic acetylcholine receptor (nAChR) antagonists have antidepressant-like properties. The present study examined the effects of lobeline, a nAChR antagonist, in the forced swim test (FST), tail suspension test (TST), and novelty suppressed feeding test (NSFT) of antidepressant efficacy. Lobeline (1 or 4 mg/kg, s.c.) was administered 20 min before the FST and TST in C57BL/6J mice. Pretreatment with lobeline significantly reduced immobility time in the FST but not in the TST. Repeated lobeline (1 or 4 mg/kg, s.c.) treatment for 21 days significantly reduced feeding latency in the NSFT. We also determined the effects of lobeline on forced swim stress (FSS)-induced increased in plasma corticosterone levels using enzyme immunoassay. Pretreatment with lobeline (1 mg/kg, s.c.) significantly attenuated the corticosterone levels. Further, the effects of lobeline on FSS-induced increased in norepinephrine (NE) and serotonin levels in the prefrontal cortex (PFC) and hippocampus were determined using high performance liquid chromatography. Pretreatment with lobeline (1 or 10 mg/kg, s.c.) significantly reduced NE levels in the PFC. Overall, the present study indicates that lobeline produces antidepressant-like effects by targeting brain nAChRs and/or neuroendocrine and brain noradrenergic systems.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA.
authors.forename: Monzurul Amin
authors.initials: MA
authors.lastname: Roni
authors.forename: Shafiqur
authors.initials: S
authors.lastname: Rahman
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D019417:Hindlimb Suspension / Q000502:physiology / Q000523:psychology; D008120:Lobeline / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D055099:Neuroendocrine Cells / Q000187:drug effects* / Q000378:metabolism; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism*; D013550:Swimming / Q000502:physiology / Q000523:psychology
chemical_list: D000928:Antidepressive Agents; D008120:Lobeline