title: Lethal effect of a single dose of rasburicase in a preterm newborn infant.
abstract: This case report describes a preterm newborn infant who was treated with a single dose of rasburicase for an increase in uric acid level. He died on the third day as a result of complications of hemolysis, which appeared to be precipitated by rasburicase. The patient's death was preceded by progressive respiratory insufficiency, lactic acidosis, and hyperbilirubinemia, culminating in refractory hypoxia and hypotension. A postmortem assay for glucose-6-phosphate dehydrogenase showed deficiency and the glucose-6-phosphate dehydrogenase Mediterranean genotype.
authors.affiliation: NICU, Women's and Children's Health Department, University of Padova, Padova, Italy. zaramella@pediatria.unipd.it
authors.forename: Patrizia
authors.initials: P
authors.lastname: Zaramella
authors.forename: Alessandra
authors.initials: A
authors.lastname: De Salvia
authors.forename: Martina
authors.initials: M
authors.lastname: Zaninotto
authors.forename: Maura
authors.initials: M
authors.lastname: Baraldi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Capovilla
authors.forename: Domenico
authors.initials: D
authors.lastname: De Leo
authors.forename: Lino
authors.initials: L
authors.lastname: Chiandetti
mesh_terms: D017809:Fatal Outcome; D006461:Hemolysis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008297:Male; D014503:Urate Oxidase / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: C469709:rasburicase; D014503:Urate Oxidase