title: Personalized medicine and atrial fibrillation: will it ever happen?
abstract: Atrial fibrillation (AF) is a common arrhythmia of substantial public health importance. Recent evidence demonstrates a heritable component underlying AF, and genetic discoveries have identified common variants associated with the arrhythmia. Ultimately one hopes that the consideration of genetic variation in clinical practice may enhance care and improve health outcomes. In this review we explore areas of potential clinical utility in AF management including those relating to pharmacogenetics and risk prediction.
authors.affiliation: Cardiovascular Research Center and Cardiac Arrhythmia Service, Massachusetts General Hospital, 149 13th Street, 4th Floor, Charlestown, MA 02129, USA. slubitz@partners.org
authors.forename: Steven A
authors.initials: SA
authors.lastname: Lubitz
authors.forename: Patrick T
authors.initials: PT
authors.lastname: Ellinor
mesh_terms: D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D010597:Pharmacogenetics; D057285:Precision Medicine; D018570:Risk Assessment