title: Dose-volume effects on brainstem dose tolerance in radiosurgery.
abstract: OBJECTIVE
  Dose-volume data concerning the brainstem in stereotactic radiosurgery (SRS) for trigeminal neuralgia (TN) were analyzed in relation to associated complications. The authors present their set of data and compare it with currently cited information on brainstem dose tolerance associated with conventional fractionated radiation therapy and hypofractionated radiation treatment of other diseases.
  
  
  METHODS
  Stereotactic radiosurgery for TN delivers a much higher radiation dose to the brainstem in a single fraction than doses delivered by any other procedures. A literature survey of articles on radiosurgery for TN revealed no incidences of severe toxicity, unlike other high-dose procedures involving the brainstem. Published data on brainstem dose tolerance were investigated and compared with dose-volume data in TN radiosurgery. The authors also performed a biological modeling study of dose-volume data involving the brainstem in cases of TN treated with the Gamma Knife, CyberKnife, and linear accelerator-based systems.
  
  
  RESULTS
  The brainstem may receive a maximum dose as high as 45 Gy during radiosurgery for TN. The major complication after TN radiosurgery is mild to moderate facial numbness, and few other severe toxic responses to radiation are observed. The biologically effective dose of 45 Gy in a single fraction is much higher than any brainstem dose tolerance currently cited in conventional fractionation or in single or hypofractionated radiation treatments. However, in TN radiosurgery, the dose falloff is so steep and the delivery so accurate that brainstem volumes of 0.1-0.5 cm(3) or larger receive lower planned and delivered doses than those in other radiation-related procedures. Current models are suggestive, but an extensive analysis of detailed dose-volume clinical data is needed.
  
  
  CONCLUSIONS
  Patients whose TN is treated with radiosurgery are a valuable population in which to demonstrate the dose-volume effects of an extreme hypofractionated radiation treatment on the brainstem. The result of TN radiosurgery suggests that a very small volume of the brainstem can tolerate a drastically high dose without suffering a severe clinical injury. The authors believe that the steep dose gradient in TN radiosurgery plays a key role in the low toxicity experienced by the brainstem.
authors.affiliation: Department of Radiation Oncology, Cooper University Hospital, Camden, New Jersey 08103, USA. xue-jinyu@cooperhealth.edu
authors.forename: Jinyu
authors.initials: J
authors.lastname: Xue
authors.forename: H Warren
authors.initials: HW
authors.lastname: Goldman
authors.forename: Jimm
authors.initials: J
authors.lastname: Grimm
authors.forename: Tamara
authors.initials: T
authors.lastname: LaCouture
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Lesley
authors.initials: L
authors.lastname: Hughes
authors.forename: Ellen
authors.initials: E
authors.lastname: Yorke
mesh_terms: D000328:Adult; D000368:Aged; D001933:Brain Stem / Q000528:radiation effects* / Q000601:surgery*; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D006941:Hyperesthesia / Q000209:etiology; D006987:Hypesthesia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D014277:Trigeminal Neuralgia / Q000601:surgery*