title: Stem cell reprogramming as a driver of basal cell carcinoma.
abstract: Basal cell carcinoma has been shown to originate from activation of hedgehog signalling in interfollicular epidermal progenitor cells. Analyses of the early steps of basal cell carcinoma formation show that this process requires reprogramming of interfolliclular epidermal cells to an embryonic hair follicle progenitor-like fate, with concomitant Wnt pathway activation.
authors.affiliation: Institute of Medical Biology, 8A Biomedical Grove, 06-06                 Immunos, 138648                 Singapore.
authors.forename: David W M
authors.initials: DW
authors.lastname: Tan
authors.forename: Nick
authors.initials: N
authors.lastname: Barker
mesh_terms: D000818:Animals; D002280:Basal Cell Carcinoma / Q000473:pathology*; D018859:Hair Follicle / Q000166:cytology*; D014411:Neoplastic Stem Cells / Q000166:cytology*