title: Cascaded photoinduced drug delivery to cells from multifunctional core-shell mesoporous silica.
abstract: Different bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.
authors.affiliation: Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Schlossbauer
authors.forename: Anna M
authors.initials: AM
authors.lastname: Sauer
authors.forename: Valentina
authors.initials: V
authors.lastname: Cauda
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schmidt
authors.forename: Hanna
authors.initials: H
authors.lastname: Engelke
authors.forename: Ulrich
authors.initials: U
authors.lastname: Rothbauer
authors.forename: Kourosh
authors.initials: K
authors.lastname: Zolghadr
authors.forename: Heinrich
authors.initials: H
authors.lastname: Leonhardt
authors.forename: Christoph
authors.initials: C
authors.lastname: Bräuchle
authors.forename: Thomas
authors.initials: T
authors.lastname: Bein
mesh_terms: D008027:Light; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000528:radiation effects* / Q000648:ultrastructure; D010316:Particle Size; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000528:radiation effects*; D016062:Porosity / Q000528:radiation effects; D011524:Protoporphyrins / Q000737:chemistry* / Q000528:radiation effects; D012822:Silicon Dioxide / Q000097:blood* / Q000528:radiation effects*
chemical_list: D053769:Nanocapsules; D017319:Photosensitizing Agents; D011524:Protoporphyrins; D012822:Silicon Dioxide; C028025:protoporphyrin IX