title: Molecular evolution of hemagglutinin (H) gene in measles virus genotypes D3, D5, D9, and H1.
abstract: We studied the molecular evolution of H gene in four prevalent Asian genotypes (D3, D5, D9, and H1) of measles virus (MeV). We estimated the evolutionary time scale of the gene by the bayesian Markov Chain Monte Carlo (MCMC) method. In addition, we predicted the changes in structure of H protein due to selective pressures. The phylogenetic tree showed that the first division of these genotypes occurred around 1931, and further division of each type in the 1960-1970s resulted in four genotypes. The rate of molecular evolution was relatively slow (5.57×10(-4) substitutions per site per year). Only two positively selected sites (F476L and Q575K) were identified in H protein, although these substitutions might not have imparted significant changes to the structure of the protein or the epitopes for phylactic antibodies. The results suggested that the prevalent Asian MeV genotypes were generated over approximately 30-40 years and H protein was well conserved.
authors.affiliation: Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi-shi, Gunma, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Saitoh
authors.forename: Makoto
authors.initials: M
authors.lastname: Takeda
authors.forename: Koichi
authors.initials: K
authors.lastname: Gotoh
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Takeuchi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Sekizuka
authors.forename: Makoto
authors.initials: M
authors.lastname: Kuroda
authors.forename: Katsumi
authors.initials: K
authors.lastname: Mizuta
authors.forename: Akihide
authors.initials: A
authors.lastname: Ryo
authors.forename: Ryota
authors.initials: R
authors.lastname: Tanaka
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Ishii
authors.forename: Hayato
authors.initials: H
authors.lastname: Takada
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Kozawa
authors.forename: Ayako
authors.initials: A
authors.lastname: Yoshida
authors.forename: Masahiro
authors.initials: M
authors.lastname: Noda
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Okabe
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kimura
mesh_terms: D019143:Evolution, Molecular; D005838:Genotype; D006388:Hemagglutinins / Q000235:genetics*; D008459:Measles virus / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D006388:Hemagglutinins; D014764:Viral Proteins