title: More radical magic with B12: B12-catalyzed, light-induced cleavage of DNA.
abstract: B(12) in a new light: the B(12) derivative hydroxocobalamin can be used as an efficient catalyst for light-induced strand cleavage of DNA. The proposed radical process involves hydroxy radicals and is controlled by visible light. Such light-controlled radical reactions promise to be particularly useful in intracellular applications.
authors.affiliation: Institute of Organic Chemistry & Centre of Molecular Biosciences, University of Innsbruck, Austria. bernhard.kraeutler@uibk.ac.at
authors.forename: Bernhard
authors.initials: B
authors.lastname: Kräutler
authors.forename: Barbara
authors.initials: B
authors.lastname: Puffer
mesh_terms: D002384:Catalysis / Q000528:radiation effects; D003038:Cobamides / Q000737:chemistry*; D053837:DNA Cleavage / Q000187:drug effects / Q000528:radiation effects*; D004269:DNA, Bacterial / Q000187:drug effects / Q000528:radiation effects; D017665:Hydroxyl Radical / Q000737:chemistry*; D008027:Light; D015394:Molecular Structure; D010957:Plasmids
chemical_list: D003038:Cobamides; D004269:DNA, Bacterial; D017665:Hydroxyl Radical; C000913:cobamamide