title: Effects of modified biliopancreatic diversion on glucose tolerance of GK rats.
abstract: BACKGROUND
  The purpose of this study was to investigate the hypoglycemic effect of new biliopancreatic diversion and duodenal-jejunal bypass in Goto-Kakizaki rats and observe effects of the new surgical procedure on the glucose tolerance of GK rats.
  
  
  METHODS
  Twenty-four 10-week-old rats (SPF grade) were randomly divided into groups A, B, and C, each with eight rats. Group A underwent duodenal-jejunal bypass, group B underwent modified biliopancreatic diversion, and group C underwent a sham operation. Median rat body weight, fasting blood glucose, OGTT, and blood lipids were measured in fasting 1 week before surgery and 1, 2, 4, and 8 weeks after surgery. Changes in gastric inhibitory polypeptide, glucagon P-like peptide-1, and insulin levels were measured by ELISA 1 week before surgery and 8 weeks after surgery.
  
  
  RESULTS
  Rats' mean body weight in groups A and B decreased significantly from 368.025 ± 11.726 and 373.100 ± 9.859 g preoperatively to 345.750 ± 11.403 and 343.260 ± 12.399 g at the early postoperative stage (P < 0.05), and with statistically significant differences compared to the weight of rats in group C (P < 0.05). Comparisons between fasting blood glucose before surgery and 8 weeks after surgery revealed no significant differences between all three groups (P > 0.05). Glucose tolerance in groups A and B decreased from preoperative 21.175 ± 3.684 and 20.820 ± 1.671 mmol/L to postoperative 8.950 ± 0.580 and 10.500 ± 1.509 mmol/L, and both were better than that of group C (P < 0.001).
  
  
  CONCLUSIONS
  Both new biliopancreatic diversion and duodenal-jejunal bypass improve glucose tolerance of Goto-Kakizaki rats.
authors.affiliation: Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Fujian Medical University, Cha-Zhong Road, Fuzhou, 350005, People's Republic of China. shangeng@sina.com
authors.forename: Shan-Geng
authors.initials: SG
authors.lastname: Weng
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Su
authors.initials: S
authors.lastname: Feng
authors.forename: Chang-Guo
authors.initials: CG
authors.lastname: Xu
authors.forename: Chun-Zhong
authors.initials: CZ
authors.lastname: Lin
mesh_terms: D000818:Animals; D015904:Biliopancreatic Diversion / Q000379:methods*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000601:surgery*; D004386:Duodenum / Q000601:surgery*; D005749:Gastric Inhibitory Polypeptide / Q000097:blood; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D007583:Jejunum / Q000601:surgery*; D008055:Lipids / Q000097:blood; D008297:Male; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1