title: Expression patterns of MDA-9/syntenin during development of the mouse embryo.
abstract: Melanoma differentiation associated gene-9 (MDA-9)/syntenin is a PDZ domain-containing adaptor protein involved in multiple diverse cellular processes including organization of protein complexes in the plasma membrane, intracellular trafficking and cell surface targeting, synaptic transmission, and cancer metastasis. In the present study, we analyzed the expression pattern of MDA-9/syntenin during mouse development. MDA-9/syntenin was robustly expressed with tight regulation of its temporal and spatial expression during fetal development in the developing skin, spinal cord, heart, lung and liver, which are regulated by multiple signaling pathways in the process of organogenesis. Recent studies also indicate that MDA-9/syntenin is involved in the signaling pathways crucial during development such as Wnt, Notch and FGF. Taken together, these results suggest that MDA-9/syntenin may play a prominent role during normal mouse development in the context of cell proliferation as well as differentiation through modulating multiple signaling pathways as a crucial adaptor protein. Additionally, temporal regulation of MDA-9/syntenin expression may be required during specific stages and in specific tissues during development.
authors.affiliation: Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Sanger Hall 11-015, 1101 East Marshall Street, Richmond, VA 23298, USA.
authors.forename: Hyun Yong
authors.initials: HY
authors.lastname: Jeon
authors.forename: Swadesh K
authors.initials: SK
authors.lastname: Das
authors.forename: Santanu
authors.initials: S
authors.lastname: Dasgupta
authors.forename: Luni
authors.initials: L
authors.lastname: Emdad
authors.forename: Devanand
authors.initials: D
authors.lastname: Sarkar
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Seok-Geun
authors.initials: SG
authors.lastname: Lee
authors.forename: Paul B
authors.initials: PB
authors.lastname: Fisher
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D018859:Hair Follicle / Q000196:embryology / Q000378:metabolism; D006321:Heart / Q000196:embryology; D008099:Liver / Q000196:embryology / Q000378:metabolism; D008168:Lung / Q000196:embryology / Q000378:metabolism; D051379:Mice; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D011247:Pregnancy; D012867:Skin / Q000196:embryology / Q000378:metabolism; D013116:Spinal Cord / Q000196:embryology / Q000378:metabolism; D053676:Syntenins / Q000235:genetics / Q000378:metabolism*
chemical_list: D053676:Syntenins