title: Risks for preeclampsia and small for gestational age: predictive values of placental growth factor, soluble fms-like tyrosine kinase-1, and inhibin A in singleton and multiple-gestation pregnancies.
abstract: OBJECTIVE
  To determine the accuracy of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and inhibin A in singleton and multiple-gestation pregnancies for predicting preeclampsia (PE) and small for gestational age (SGA).
  
  
  METHODS
  A prospective cohort nested in a randomized controlled trial of antioxidant supplementation for the prevention of PE. Plasma biomarkers were evaluated at 12 to 18 (visit 1) and 24 to 26 (visit 2) weeks' gestation and expressed as adjusted multiples of the median.
  
  
  RESULTS
  Multiple-gestation pregnancy (74/772) had a significant impact on all biomarkers' levels. PlGF was the best predictor of PE and SGA. At a 10% false-positive rate, PlGF at visit 1 had 21% sensitivity for predicting PE in singleton versus 60% in multiple-gestation pregnancies. PlGF at visit 1 had a 31% sensitivity in singleton and 27% in multiple-gestation pregnancies for SGA prediction.
  
  
  CONCLUSIONS
  PlGF level was a good predictor of subsequent PE as early as 12 to 18 weeks in multiple-gestation pregnancies but was not clinically useful enough to be used as a single marker.
authors.affiliation: Department of Obstetrics and Gynecology, CHU Sainte-Justine Research Center, Université de Montréal, Montreal, Quebec H3T 1C5, Canada. isabelle@boucoiran.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Boucoiran
authors.forename: Sarah
authors.initials: S
authors.lastname: Thissier-Levy
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Wu
authors.forename: Shu-Qin
authors.initials: SQ
authors.lastname: Wei
authors.forename: Zhong-Cheng
authors.initials: ZC
authors.lastname: Luo
authors.forename: Edgard
authors.initials: E
authors.lastname: Delvin
authors.forename: William D
authors.initials: WD
authors.lastname: Fraser
authors.forename: Francois
authors.initials: F
authors.lastname: Audibert
mesh_terms: D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007265:Inhibins / Q000097:blood*; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D059286:Pregnancy, Triplet / Q000097:blood; D059285:Pregnancy, Twin / Q000097:blood; D012372:ROC Curve; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; C000608036:PGF protein, human; D011257:Pregnancy Proteins; C422362:inhibin A; D000072483:Placenta Growth Factor; D007265:Inhibins; D040281:Vascular Endothelial Growth Factor Receptor-1