title: The Saccharomyces cerevisiae protein Stm1p facilitates ribosome preservation during quiescence.
abstract: Once cells exhaust nutrients from their environment, they enter an alternative resting state known as quiescence, whereby proliferation ceases and essential nutrients are obtained through internal stores and through the catabolism of existing macromolecules and organelles. One example of this is ribophagy, the degradation of ribosomes through the process of autophagy. However, some ribosomes need to be preserved for an anticipated recovery from nutrient deprivation. We found that the ribosome-associated protein Stm1p greatly increases the quantity of 80S ribosomes present in quiescent yeast cells and that these ribosomes facilitate increased protein synthesis rates once nutrients are restored. These findings suggest that Stm1p can act as a ribosome preservation factor under conditions of nutrient deprivation and restoration.
authors.affiliation: Department of Chemistry and Physics, Western Carolina University, 111 Memorial Drive, Cullowhee, NC 28723, USA.
authors.forename: Natalya
authors.initials: N
authors.lastname: Van Dyke
authors.forename: Ekkawit
authors.initials: E
authors.lastname: Chanchorn
authors.forename: Michael W
authors.initials: MW
authors.lastname: Van Dyke
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D011132:Polyribosomes / Q000378:metabolism*; D014176:Protein Biosynthesis; D054683:Ribosome Subunits, Large, Eukaryotic / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D020123:Sirolimus / Q000494:pharmacology
chemical_list: D004268:DNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; C528347:Stm1 protein, S cerevisiae; D020123:Sirolimus