title: Engineering of indole-based tethered biheterocyclic alkaloid meridianin into β-carboline-derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization.
abstract: A mild, efficient and versatile method has been developed for the construction of a functionalized natural product, meridianin, and its post conversion to pyrimido-β-carboline by cationic π- cyclization. The strategy involves the introduction of an amino group at the C-5 of the pyrimidine ring and utilizing the nucleophilictiy of the C-2 in the indole ring to facilitate cationic π-cyclization.
authors.affiliation: Division of Medicinal and Process Chemistry, Central Drug Research Institute, CSIR, Lucknow, 226001, India, ;
authors.forename: Piyush Kumar
authors.initials: PK
authors.lastname: Agarwal
authors.forename: Meena Devi
authors.initials: MD
authors.lastname: Dathi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Saifuddin
authors.forename: Bijoy
authors.initials: B
authors.lastname: Kundu