title: Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ-induced hyperglycemic rats.
abstract: OBJECTIVE
  To investigate the protective role of Cardiospermum halicacabum (C. halicacabum) leaf extract on glycoprotein metabolism in streptozotocin (STZ)-induced diabetic rats.
  
  
  METHODS
  Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ. The C. halicacabum leaf extract (CHE) was administered orally to normal and STZ-diabetic rats for 45 days. The effects of C. halicacabum leaf extract (CHE) on plasma and tissue glycoproteins (hexose, hexosamine, fucose and sialic acid) were determined.
  
  
  RESULTS
  The levels of plasma and tissues glycoproteins containing hexose, hexosamine and fucose were significantly increased in STZ-induced diabetic rats. In addition, the level of sialic acid significantly increased in plasma and liver while decreased in kidney of STZ-induced diabetic rats. After administration of CHE to diabetic rats, the metabolic alteration of glycoprotein reverted towards normal levels.
  
  
  CONCLUSIONS
  The present study indicates that the CHE possesses a protective effect on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity.
authors.affiliation: Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia. chinnaveeramani@gmail.com
authors.forename: Chinnadurai
authors.initials: C
authors.lastname: Veeramani
authors.forename: Khalid S
authors.initials: KS
authors.lastname: Al-Numair
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Alsaif
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Chandramohan
authors.forename: Nouf S
authors.initials: NS
authors.lastname: Al-Numair
authors.forename: Kodukkur Viswanathan
authors.initials: KV
authors.lastname: Pugalendi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D005643:Fucose / Q000097:blood / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006595:Hexosamines / Q000097:blood / Q000378:metabolism; D006601:Hexoses / Q000097:blood / Q000378:metabolism; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D007668:Kidney / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000097:blood / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D029631:Sapindaceae / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D006023:Glycoproteins; D006595:Hexosamines; D006601:Hexoses; D010936:Plant Extracts; D020011:Protective Agents; D005643:Fucose; D019158:N-Acetylneuraminic Acid