title: Prospects for treatment of latent HIV.
abstract: Recent advances in antiretroviral therapy (ART) have drastically improved the quality of life for people with HIV infection. However, owing to the persistence of latent HIV in the presence of therapy, patients must remain on therapy indefinitely. Currently, the solution to the HIV pandemic rests on the prevention of new infections and many decades of ART for the steadily expanding number of people infected worldwide. ART is costly, requires ongoing medical care, and can have side effects, thereby preventing its universal availability. Therefore, to escape the ironic burdens of therapy, efforts have begun to develop treatments for latent HIV infection. Current approaches propose either complete eradication of infection or induction of a state of stringent control over viral replication without ART. This review will discuss these strategies in detail and their potential for clinical development.
authors.affiliation: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Barton
authors.forename: B D
authors.initials: BD
authors.lastname: Burch
authors.forename: N
authors.initials: N
authors.lastname: Soriano-Sarabia
authors.forename: D M
authors.initials: DM
authors.lastname: Margolis
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods / Q000639:trends*; D002986:Clinical Trials as Topic / Q000379:methods / Q000639:trends; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D016896:Treatment Outcome; D017735:Virus Latency / Q000187:drug effects* / Q000235:genetics
chemical_list: D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents