title: Ultrasound-promoted greener synthesis of novel trifurcate 3-substituted-chroman-2,4-dione derivatives and their drug-likeness evaluation.
abstract: An efficient and convenient approach for one-pot synthesis of 3-substituted chroman-2,4-diones via a three-component reaction of aromatic aldehydes, 4-hydroxy-coumarins and diverse pyrazolone derivatives was described. The combinatorial synthesis for this methodology was achieved by applying ultrasound irradiation in the absence of activator while making use of water as green solvent. Additionally, novel chroman-2,4-dione derivatives attached to an edaravone moiety represent an exploitable source of brand new anticancer agents. In comparison with conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and atom efficiency are prominent features of this sonocatalyzed procedure.
authors.affiliation: School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
authors.forename: Chengyuan
authors.initials: C
authors.lastname: Liang
authors.forename: Hailong
authors.initials: H
authors.lastname: Jiang
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Zhou
authors.forename: Dong
authors.initials: D
authors.lastname: Lei
authors.forename: Yu
authors.initials: Y
authors.lastname: Xue
authors.forename: Qizheng
authors.initials: Q
authors.lastname: Yao
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000983:Antipyrine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D002839:Chromans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002867:Chromones / Q000737:chemistry*; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry; D000077553:Edaravone; D015394:Molecular Structure; D047069:Pyrazolones / Q000138:chemical synthesis / Q000737:chemistry; D013016:Sound; D014867:Water / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000970:Antineoplastic Agents; D002839:Chromans; D002867:Chromones; D003374:Coumarins; D047069:Pyrazolones; D014867:Water; C038362:pyrazolone; D000077553:Edaravone; D000983:Antipyrine