title: Treatment-limiting decisions, comorbidities, and mortality in the emergency departments:  a cross-sectional elderly population-based study.
abstract: BACKGROUND
  Older adults experience a higher risk of death in the emergency departments (EDs), in part, as a result of their comorbidities. A treatment-limiting decision is often reported for older adults who die in the EDs. The Charlson Comorbidity Index (CCI) is a validated method for the scoring of comorbidities. Whether an association between the CCI and treatment-limiting decisions exists remains unknown.
  
  
  OBJECTIVE
  To determine whether the CCI was associated with the treatment-limiting decisions made for older patients who die in the EDs.
  
  
  METHODS
  A total of 2,095 patients ≥65 years old who died in the EDs in France and Belgium were prospectively included between 2004 and 2005. The recorded data included: 1) the CCI score; 2) patient age; 3) gender; 4) living in senior housing facilities; 5) hospitalizations occurring in the previous year; 6) presence of functional limitations (according to the Knaus classification); 7) chronic diseases; and 8) presence of organ failure(s). A treatment-limiting decision was defined as a predetermined choice not to implement therapies that would otherwise be required to sustain life.
  
  
  RESULTS
  A treatment-limiting decision was identified in 993 (47%) patients. Fully-adjusted logistic regression model showed that a CCI ≥ 5 (OR=25.56 with P=0.037), age ≥85years (OR=20.33 with P<0.001), living in an institution (OR=0.15 with P=0.017), hematologic (OR=6.92 with P=0.020) and respiratory disease (OR=0.17 with P=0.046), and neurologic causes (OR=0.20 with P=0.010) of organ failure were significantly associated with treatment-limiting decisions.
  
  
  CONCLUSIONS
  An elevated CCI score (≥5) was associated with a treatment-limiting decision in elderly patients evaluated in the EDs. Further research is needed to corroborate this finding.
authors.affiliation: Department of Geriatrics, Nantes University Hospital, Nantes, France. laure.dedecker@chu-nantes.fr
authors.forename: L
authors.initials: L
authors.lastname: de Decker
authors.forename: O
authors.initials: O
authors.lastname: Beauchet
authors.forename: A
authors.initials: A
authors.lastname: Gouraud-Tanguy
authors.forename: G
authors.initials: G
authors.lastname: Berrut
authors.forename: C
authors.initials: C
authors.lastname: Annweiler
authors.forename: P
authors.initials: P
authors.lastname: Le Conte
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001530:Belgium; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003657:Decision Making; D004630:Emergencies; D004636:Emergency Service, Hospital; D005260:Female; D005602:France; D006402:Hematologic Diseases / Q000150:complications; D006798:Housing; D006801:Humans; D007326:Institutionalization; D016015:Logistic Models; D008297:Male; D009026:Mortality; D016017:Odds Ratio; D011446:Prospective Studies; D012140:Respiratory Tract Diseases / Q000150:complications