title: Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma.
abstract: We previously identified genes associated with Snail-mediated squamous cell carcinoma (SCC) invasiveness, in which we observed significant elevation of Cyr61 expression. In this study, SCC cell lines overexpressing Cyr61 exhibited constitutive activation of Rho A and upregulated invasiveness without the disruption of homophilic cell attachment. Humoral Cyr61 enhanced further production of endogenous Cyr61 by SCC cells, which stimulated collective cell migration and the development of an invasive tumor nest. We propose a Cyr61-dependent model for the development of invasive SCC nest, whereby a subset of tumor cells that highly produce Cyr61 may direct other tumor cells to undergo collective cell migration, resulting in a formation of primary SCC mass.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Fumi
authors.initials: F
authors.lastname: Tanaka
authors.forename: Andra
authors.initials: A
authors.lastname: Rizqiawan
authors.forename: Koichiro
authors.initials: K
authors.lastname: Higashikawa
authors.forename: Kei
authors.initials: K
authors.lastname: Tobiume
authors.forename: Gaku
authors.initials: G
authors.lastname: Okui
authors.forename: Hideo
authors.initials: H
authors.lastname: Shigeishi
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Ono
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimasue
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kamata
mesh_terms: D001665:Binding Sites; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D055515:Cysteine-Rich Protein 61 / Q000378:metabolism*; D058750:Epithelial-Mesenchymal Transition; D025461:Feedback, Physiological; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D017930:Genes, Reporter; D006801:Humans; D016023:Integrins / Q000378:metabolism; D049410:Luciferases, Renilla / Q000096:biosynthesis / Q000235:genetics; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology*; D009361:Neoplasm Invasiveness; D011401:Promoter Regions, Genetic; D015398:Signal Transduction; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: C501848:CCN1 protein, human; D055515:Cysteine-Rich Protein 61; D016023:Integrins; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors; D049410:Luciferases, Renilla