title: InnateDB: systems biology of innate immunity and beyond--recent updates and continuing curation.
abstract: InnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes. In this article, we provide details of recent updates and improvements to the database. InnateDB now contains >196 000 human, mouse and bovine experimentally validated molecular interactions and 3000 pathway annotations of relevance to all mammalian cellular systems (i.e. not just immune relevant pathways and interactions). In addition, the InnateDB team has, to date, manually curated in excess of 18 000 molecular interactions of relevance to innate immunity, providing unprecedented insight into innate immunity networks, pathways and their component molecules. More recently, InnateDB has also initiated the curation of allergy- and asthma-related interactions. Furthermore, we report a range of improvements to our integrated bioinformatics solutions including web service access to InnateDB interaction data using Proteomics Standards Initiative Common Query Interface, enhanced Gene Ontology analysis for innate immunity, and the availability of new network visualizations tools. Finally, the recent integration of bovine data makes InnateDB the first integrated network analysis platform for this agriculturally important model organism.
authors.affiliation: Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A1S6, Canada.
authors.forename: Karin
authors.initials: K
authors.lastname: Breuer
authors.forename: Amir K
authors.initials: AK
authors.lastname: Foroushani
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Laird
authors.forename: Carol
authors.initials: C
authors.lastname: Chen
authors.forename: Anastasia
authors.initials: A
authors.lastname: Sribnaia
authors.forename: Raymond
authors.initials: R
authors.lastname: Lo
authors.forename: Geoffrey L
authors.initials: GL
authors.lastname: Winsor
authors.forename: Robert E W
authors.initials: RE
authors.lastname: Hancock
authors.forename: Fiona S L
authors.initials: FS
authors.lastname: Brinkman
authors.forename: David J
authors.initials: DJ
authors.lastname: Lynn
mesh_terms: D000818:Animals; D002417:Cattle; D003196:Computer Graphics; D030541:Databases, Genetic; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D020407:Internet; D051379:Mice; D058977:Molecular Sequence Annotation; D040901:Proteomics; D012984:Software; D049490:Systems Biology; D014584:User-Computer Interface