title: The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship.
abstract: Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral (LH), perifornical, and dorsomedial (DMH) hypothalamus. These neurons innervate many regions in the brain and modulate multiple other neurotransmitter systems. As a result of these extensive projections and interactions orexins are involved in numerous functions, such as feeding behavior, neuroendocrine regulation, the sleep-wake cycle, and reward-seeking. This review will summarize the literature to date which has evaluated a role of orexins in the behavioral effects of alcohol, with a focus on understanding the importance of this peptide and its potential as a clinical therapeutic target for alcohol use disorders.
authors.affiliation: Addiction Neuroscience Laboratory, Behavioural Neuroscience Division, Florey Neuroscience Institutes, University of Melbourne Parkville, VIC, Australia ; Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo São Paulo, Brazil.
authors.forename: Andrezza K
authors.initials: AK
authors.lastname: Kim
authors.forename: Robyn M
authors.initials: RM
authors.lastname: Brown
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lawrence