title: Periodic plasmonic enhancing epitopes on a whispering gallery mode biosensor.
abstract: We propose the attachment of a periodic array of gold nanoparticles (epitopes) to the equator of a Whispering Gallery Mode Biosensor for the purpose of plasmonically enhancing nanoparticle sensing in a self-referencing manner while increasing the capture rate of analyte to antibodies attached to these plasmonic epitopes. Our approach can be applied to a variety of whispering gallery mode resonators from silicon/silica rings and disks to capillaries. The interpretation of the signals is particularly simple since the optical phase difference between the epitopes is designed to be an integer multiple of ?, allowing the wavelength shift from each binding event to add independently.
authors.affiliation: Department of Applied Physics, Polytechnic Institute of NYU, Brooklyn, New York 11201, USA. SArnold935@aol.com
authors.forename: Stephen
authors.initials: S
authors.lastname: Arnold
authors.forename: Venkata Ramanaiah
authors.initials: VR
authors.lastname: Dantham
authors.forename: Curtis
authors.initials: C
authors.lastname: Barbre
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Garetz
authors.forename: Xudong
authors.initials: X
authors.lastname: Fan
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D000939:Epitopes; D004867:Equipment Design; D006046:Gold; D006801:Humans; D053758:Nanoparticles; D055096:Optical Devices; D012031:Refractometry / Q000295:instrumentation*; D015203:Reproducibility of Results; D012822:Silicon Dioxide; D013817:Thermography / Q000295:instrumentation*
chemical_list: D000939:Epitopes; D006046:Gold; D012822:Silicon Dioxide