title: C-C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature.
abstract: Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I), Ag(I), and Au(III) leads to 1,4-adducts in good isolated yields: no organometallic precursor need be formed.
authors.affiliation: Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, United States. lipshutz@chem.ucsb.edu
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Lipshutz
authors.forename: Shenlin
authors.initials: S
authors.lastname: Huang
authors.forename: Wendy Wen Yi
authors.initials: WW
authors.lastname: Leong
authors.forename: Guofu
authors.initials: G
authors.lastname: Zhong
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Isley
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000473:Alkanes; D007659:Ketones; D014867:Water; D003300:Copper