title: The antiinflammatory activity of extracts from the root of Combretum dolichopetalum.
abstract: The methanol and chloroform extracts of the root of Combretum dolichopetalum were obtained and gave yields of 6.48% w/w and 0.38% w/w respectively. The methanol extract significantly inhibited carageenin-induced mouse paw edema in a dose-dependent manner after an oral treatment. The maximum effect was achieved at a dose of 600 mg/kg and the result was comparable to that of indomethacin (10 mg/kg). The antiinflammatory activity of the chloroform extract against croton-oil induced mouse ear edema was significant (p < 0.001) and increased with the dose. The maximum effect (93%) was achieved with 1.0 mg of the extract per ear.
authors.affiliation: Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka.
authors.forename: I U
authors.initials: IU
authors.lastname: Asuzu
authors.forename: R I
authors.initials: RI
authors.lastname: Adimorah