title: Separation and determination of fluorobenzoic acids using ion chromatography-electrospray mass spectrometry.
abstract: A method for the trace analysis of fluorobenzoic acids (FBAs) via IC-MS based on solid-phase extraction (SPE) prior to isocratic anion exchange chromatography is described. Up to 23 different fluorobenzoic acids were enriched and determined simultaneously. Solid-phase extraction on hydrophilic-lipophilic-balanced reversed-phase cartridges containing a poly(divinylbenzene-co-N-vinylpyrrolidone) polymer allowed a 500-fold enrichment of the acids if 100mL sample was used with recoveries between 28% and 98%. The method enables the determination of FBAs down to the range of 16-210 ng L(-1), provides sample-preparation (pH-adjusting prior to SPE only) with no need of derivatization, uses low amounts of chemicals and is adaptable to larger or smaller sample volumes.
authors.affiliation: University of Marburg, Institute of Analytical Chemistry, D-35032 Marburg, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Müller
authors.forename: Andreas
authors.initials: A
authors.lastname: Seubert
mesh_terms: D001565:Benzoates / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D002852:Chromatography, Ion Exchange / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D015203:Reproducibility of Results; D052616:Solid Phase Extraction; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D001565:Benzoates; D014874:Water Pollutants, Chemical