title: Anti-cAngptl4 Ab-conjugated N-TiO(2) /NaYF(4) :Yb,Tm nanocomposite for near infrared-triggered drug release and enhanced targeted cancer cell ablation.
abstract: Nanomedicine: NIR-active N-TiO(2) /NaYF(4) :Yb,Tm nanocomposites (NCs) were synthesized for the first time and its potential applications in drug release and targeted cancer cell ablation are explored. Upon 980 nm laser irradiation, the anti-cAngptl4 Ab-conjugated N-TiO(2) /NaYF(4) :Yb,Tm NCs shows a significant increase in apoptotic A-5RT3 cells when compared with that of the unconjugated NCs. The mechanisms for NIR-induced photocatalysis, drug release and targeted cancer cell killing are proposed.
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore.
authors.forename: Qing Chi
authors.initials: QC
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ming Jie
authors.initials: MJ
authors.lastname: Tan
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Shaojun
authors.initials: S
authors.lastname: Yuan
authors.forename: Cleo
authors.initials: C
authors.lastname: Choong
authors.forename: Nguan Soon
authors.initials: NS
authors.lastname: Tan
authors.forename: Timothy Thatt Yang
authors.initials: TT
authors.lastname: Tan
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D005459:Fluorides / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays / Q000627:therapeutic use; D053769:Nanocapsules / Q000528:radiation effects / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000628:therapy*; D014025:Titanium / Q000528:radiation effects / Q000627:therapeutic use*; D015019:Yttrium / Q000737:chemistry*
chemical_list: D000911:Antibodies, Monoclonal; D053769:Nanocapsules; C525362:sodium yttriumtetrafluoride; C009495:titanium dioxide; D015019:Yttrium; D014025:Titanium; D005459:Fluorides