title: A case in which mirtazapine reduced auditory hallucinations in a patient with Parkinson disease.
abstract: A 48-year-old woman with Parkinson disease (PD) suffered from auditory hallucinations (AH). We had treated her with a reduction in antiparkinsonian agents and the use of atypical antipsychotic agents. However, her symptoms did not improve, and her extrapyramidal symptoms (EPS) worsened. To lessen her depressive symptoms, treatment with a new-generation antidepressant, mirtazapine (MRZ), was commenced. The patient's AH gradually decreased with no worsening of EPS, and the AH disappeared 4 weeks after the commencement of treatment with MRZ. The present case suggests the effectiveness of MRZ for the treatment of refractory AHs in patients with PD.
authors.affiliation: Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan. t.nagata@jikei.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Nagata
authors.forename: Shunichiro
authors.initials: S
authors.lastname: Shinagawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Tagai
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakayama
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000188:drug therapy; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006212:Hallucinations / Q000188:drug therapy*; D006801:Humans; D008803:Mianserin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D000078785:Mirtazapine; D010300:Parkinson Disease / Q000188:drug therapy* / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D000929:Antidepressive Agents, Tricyclic; D008803:Mianserin; D000078785:Mirtazapine