title: Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea.
abstract: OBJECTIVE
  To evaluate hepatic morphological-histological abnormalities in newborns from female rats exposed to ethylenethiourea.
  
  
  METHODS
  A randomized study was conducted on fifty-five newborn Wistar rats were studied: 34 in the experimental group, whose mothers had been exposed to 1% ethylenethiourea; and 21 in the control group, whose mothers had received 0.9% physiological solution. The solution was administered via gavage on the 11(th) day of gestation. Cesarean section was performed on the 20(th) day of gestation. The newborns' livers were examined and any morphological-histological abnormalities were registered. The presence of megakaryocytes was quantified in 50 microscope fields, as the total number of these cells per mm(2).
  
  
  RESULTS
  The entire experimental group presented abnormalities of embryonic formation, with musculoskeletal anomalies, digestive system anomalies, hepatic congestion and friability, hydrops and delayed intrauterine growth. The histopathological analysis showed that morphological-histological hepatic destructuring had occurred in all entire experimental with removal of the hepatic trabeculae and severe hepatic megakaryocytosis. The mean megakaryocyte density ranged from 107.9 to 114.2 per mm(2), and it was eight times greater than in the control group, thus characterizing a situation of extramedullary hematopoiesis.
  
  
  CONCLUSIONS
  The fetal exposure to ethylenethiourea caused hepatic damage characterized by severe extramedullary hematopoiesis.
authors.affiliation: Department of Medicine, Sao Francisco Valley Federal University, Brazil. sppls@hotmail.com
authors.forename: Patrícia Veruska Ribeiro Barbosa
authors.initials: PV
authors.lastname: Lemos
authors.forename: José Luiz
authors.initials: JL
authors.lastname: Martins
authors.forename: Sidney Pereira Pinto
authors.initials: SP
authors.lastname: Lemos
authors.forename: Fernando Leandro dos
authors.initials: FL
authors.lastname: Santos
authors.forename: Sílvio Romero Gonçalves e
authors.initials: SR
authors.lastname: Silva
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology*; D005031:Ethylenethiourea / Q000633:toxicity*; D005260:Female; D006411:Hematopoiesis, Extramedullary / Q000187:drug effects; D023421:Models, Animal; D010575:Pesticides / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010575:Pesticides; D005031:Ethylenethiourea