title: Novel experimental cements for use on the dentin-pulp complex.
abstract: This aim of this study was to evaluate the physicochemical and biological properties of novel experimental cements (Hybrid, Paste and Resin) based on synergistic combinations of existing materials, including pH, diametral tensile strength (DTS) and cytotoxicity comparing them with mineral trioxide aggregate (MTA - Angelus®) and a glass ionomer cement (GIC) developed at our laboratory. For the physicochemical and biological tests, specimens with standard dimensions were produced. pH measurements were performed with digital pH meter at the following time intervals: 3, 24, 48 and 72 h. For the DTS test, cylindrical specimens were subjected to compressive load until fracture. The MTT assay was performed for cytotoxicity evaluation. Data were analyzed by ANOVA and Tukey's test (α=0.05). Paste group showed pH values similar to MTA, and Hybrid group presented pH values similar to GIC (p>0.05). The tested materials showed pH values ranging from alkaline to near neutrality at the evaluated times. MTA and GIC showed similar DTS values. The lowest and highest DTS values were seen in the Paste and Resin groups, respectively (p<0.05). Cell viability for MTA and experimental Hybrid, Paste and Resin groups was 49%, 93%, 90% and 86%, respectively, when compared with the control group. The photo-cured experimental resin cement showed similar or superior performance compared with the current commercial or other tested experimental materials.
authors.affiliation: Federal University of Pelotas, Pelotas, RS, Brazil.
authors.forename: Raquel Venâncio Fernandes
authors.initials: RV
authors.lastname: Dantas
authors.forename: Marcus Cristian Muniz
authors.initials: MC
authors.lastname: Conde
authors.forename: Hugo Ramalho
authors.initials: HR
authors.lastname: Sarmento
authors.forename: Cesar Henrique
authors.initials: CH
authors.lastname: Zanchi
authors.forename: Sandra Beatriz Chaves
authors.initials: SB
authors.lastname: Tarquinio
authors.forename: Fabrício Aulo
authors.initials: FA
authors.lastname: Ogliari
authors.forename: Flávio Fernando
authors.initials: FF
authors.lastname: Demarco
mesh_terms: D016475:3T3 Cells; D017607:Aluminum Compounds / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001729:Bismuth / Q000737:chemistry / Q000633:toxicity; D017610:Calcium Compounds / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D003188:Composite Resins / Q000737:chemistry / Q000633:toxicity; D003738:Dental Cements / Q000737:chemistry* / Q000633:toxicity; D004338:Drug Combinations; D005347:Fibroblasts / Q000187:drug effects; D005899:Glass Ionomer Cements / Q000737:chemistry / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D055115:Light-Curing of Dental Adhesives; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry / Q000633:toxicity; D051379:Mice; D010087:Oxides / Q000737:chemistry / Q000633:toxicity; D011092:Polyethylene Glycols / Q000737:chemistry / Q000633:toxicity; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000633:toxicity; D011140:Polyurethanes / Q000737:chemistry / Q000633:toxicity; D057872:Pulp Capping and Pulpectomy Agents / Q000737:chemistry* / Q000633:toxicity; D019279:Resin Cements / Q000737:chemistry / Q000633:toxicity; D055116:Self-Curing of Dental Resins; D017640:Silicates / Q000737:chemistry / Q000633:toxicity; D013314:Stress, Mechanical; D013718:Tensile Strength; D013997:Time Factors
chemical_list: D017607:Aluminum Compounds; D001672:Biocompatible Materials; D017610:Calcium Compounds; D003188:Composite Resins; D003738:Dental Cements; D004338:Drug Combinations; D005899:Glass Ionomer Cements; C475480:MTA-Angelus; D008689:Methacrylates; D010087:Oxides; D011109:Polymethacrylic Acids; D011140:Polyurethanes; D057872:Pulp Capping and Pulpectomy Agents; D019279:Resin Cements; D017640:Silicates; C086631:mineral trioxide aggregate; C524499:polyethylene glycol methacrylate; C029824:urethane dimethacrylate luting resin; C020946:triethylene glycol dimethacrylate; C041979:2,2-bis-(4-(2-methacryloxyethoxy)phenyl)propane; D011092:Polyethylene Glycols; D001729:Bismuth