title: Impact of immunosenescence on transplant outcome.
abstract: Aging affects all compartments of the immune response and has a major impact on transplant outcome and organ quality. Although clinical trials in the aging transplant population remain rare, our current understanding of immunosenescence provides a basis for an age-adapted immunosuppression and organ allocation with the goal to optimize utilization and to improve outcomes in older recipients. From a more general perspective, understanding the mechanisms and consequences of immunosenescence will have a broad impact on immune therapies in and beyond transplantation.
authors.affiliation: Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Timm
authors.initials: T
authors.lastname: Heinbokel
authors.forename: Karin
authors.initials: K
authors.lastname: Hock
authors.forename: Guangxiang
authors.initials: G
authors.lastname: Liu
authors.forename: Karoline
authors.initials: K
authors.lastname: Edtinger
authors.forename: Abdallah
authors.initials: A
authors.lastname: Elkhal
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Tullius
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000276:immunology* / Q000502:physiology; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate / Q000502:physiology*; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology / Q000379:methods; D016031:Liver Transplantation / Q000009:adverse effects / Q000276:immunology / Q000379:methods; D019520:Living Donors; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects / Q000379:methods*; D011379:Prognosis; D018570:Risk Assessment; D014019:Tissue Donors; D014181:Transplantation Immunology / Q000276:immunology* / Q000502:physiology