title: Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis.
abstract: We investigated the HLA-DRB1*1501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg=3.06×10(-9)) and allele frequency (Pa=6.08×10(-10)) between MS patients and controls was demonstrated. The homozygotes AA and heterozygotes GA were more frequent in MS patients (OR=4.27, 95% CI: 2.64-6.92). A significant difference between female MS patients and female controls in genotype distribution (Pg=1.3×10(-8)) and allele frequency (Pa=2.82×10(-9)); (OR=5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population.
authors.affiliation: Department of Neurology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic. beneivo@seznam.cz
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Benešová
authors.forename: Anna
authors.initials: A
authors.lastname: Vašků
authors.forename: Pavel
authors.initials: P
authors.lastname: Stourač
authors.forename: Magdalena
authors.initials: M
authors.lastname: Hladíková
authors.forename: Adam
authors.initials: A
authors.lastname: Fiala
authors.forename: Josef
authors.initials: J
authors.lastname: Bednařík
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004198:Disease Susceptibility / Q000453:epidemiology; D005260:Female; D056726:Genetic Association Studies; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000453:epidemiology / Q000235:genetics*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012737:Sex Factors
chemical_list: D059811:HLA-DRB1 Chains; C489631:HLA-DRB1*15:01 antigen