title: Construction of network for protein kinases that play a role in acute pancreatitis.
abstract: OBJECTIVE
  This study aimed to search for protein kinases that play a role in acute pancreatitis and analyze their potential connection with each other.
  
  
  METHODS
  Information of human protein kinases were collected in protein kinase database, and then a systematic search was performed using PubMed for studies addressing the association between these kinases and acute pancreatitis. Gene Ontology Annotations were used to build interactions network for acute pancreatitis-associated protein kinases.
  
  
  RESULTS
  A total of 570 human protein kinases were found, in which 28 kinases play a role in acute pancreatitis. Among the 28 kinases, RIPK1, JAK2, SRC, EGFR, FYN, MET, JAK1, TYK2, and MTOR were annotated in Gene Ontology database. A gene ontology interactions network was built to visualize the common biological process these kinases participated in.
  
  
  CONCLUSIONS
  This study provides observations that protein kinases participate in all the sequential events in the exocrine pancreas in acute pancreatitis and that protein kinases are potential therapeutical target for acute pancreatitis.
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Zhituo
authors.initials: Z
authors.lastname: Li
authors.forename: Biao
authors.initials: B
authors.lastname: Ma
authors.forename: Ming
authors.initials: M
authors.lastname: Lu
authors.forename: Xin
authors.initials: X
authors.lastname: Qiao
authors.forename: Bei
authors.initials: B
authors.lastname: Sun
authors.forename: Weihui
authors.initials: W
authors.lastname: Zhang
authors.forename: Dongbo
authors.initials: D
authors.lastname: Xue
mesh_terms: D057225:Data Mining; D030541:Databases, Genetic; D006801:Humans; D020935:MAP Kinase Signaling System; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D010195:Pancreatitis / Q000201:enzymology* / Q000209:etiology* / Q000235:genetics; D000073718:Pancreatitis-Associated Proteins; D011494:Protein Kinases / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000073718:Pancreatitis-Associated Proteins; C000612141:REG3A protein, human; D017382:Reactive Oxygen Species; D011494:Protein Kinases