title: Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice.
abstract: The impact of two commercially available products, a patented herb extract Yerbe Maté, Guarana and Damiana (YGD) formulation and an inulin-based soluble fermentable fibre (SFF), alone or in combination, on appetite and food intake were studied for the first time in a double blind, placebo-controlled, cross-over design. 58 normal to slightly overweight women consumed a fixed-load breakfast followed 4h later by an ad libitum lunch. They were administered YGD (3 tablets) and SFF (5g in 100ml water), YGD and water (100ml), SFF and placebo (3 tablets) or water and placebo 15min before meals. Appetite was assessed using visual analogue scales, and energy intake was measured at lunch. Significant reductions in food intake and energy intake were observed when YGD was present (59.5g, 16.3%; 112.4kcal, 17.3%) and when SFF was present (31.9g, 9.1%; 80kcal, 11.7%) compared with conditions were products were absent. The lowest intake (gram and kcal) was in the YGD+SFF condition. Significant reductions in AUC hunger and AUC desire to eat were also observed after YGD+SFF combination. The data demonstrate that YGD produces a robust short-term effect on caloric intake, an effect augmented by SFF. Caloric compensation for SFF indicates independent effects on appetite regulation.
authors.affiliation: Kissileff Laboratory for the Study of Human Ingestive Behaviour, Department of Experimental Psychology, Institute of Psychology, Health and Society, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, UK. harrold@liverpool.ac.uk
authors.forename: J A
authors.initials: JA
authors.lastname: Harrold
authors.forename: G M
authors.initials: GM
authors.lastname: Hughes
authors.forename: K
authors.initials: K
authors.lastname: O'Shiel
authors.forename: E
authors.initials: E
authors.lastname: Quinn
authors.forename: E J
authors.initials: EJ
authors.lastname: Boyland
authors.forename: N J
authors.initials: NJ
authors.lastname: Williams
authors.forename: J C G
authors.initials: JC
authors.lastname: Halford
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001066:Appetite / Q000187:drug effects* / Q000502:physiology; D019540:Area Under Curve; D018592:Cross-Over Studies; D004032:Diet; D004043:Dietary Fiber / Q000494:pharmacology* / Q000627:therapeutic use; D004311:Double-Blind Method; D002149:Energy Intake / Q000187:drug effects*; D005260:Female; D005518:Food Preferences / Q000187:drug effects*; D006801:Humans; D030019:Ilex paraguariensis; D007444:Inulin / Q000494:pharmacology* / Q000627:therapeutic use; D062407:Meals; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology / Q000517:prevention & control*; D050177:Overweight; D032126:Paullinia; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D016037:Single-Blind Method; D029647:Turnera; D055815:Young Adult
chemical_list: D004043:Dietary Fiber; D010936:Plant Extracts; D007444:Inulin