title: Daptomycin serum levels in critical patients undergoing continuous renal replacement.
abstract: BACKGROUND
  Daptomycin pharmacokinetics has not been extensively studied in patients undergoing continuous renal replacement therapy (CRRT).
  
  
  METHODS
  The aim of the study was to collect pharmacokinetics and clinical data of patients undergoing CRRT and receiving daptomycin  therapy. Daptomycin was measured using an isocratic high-performance liquid chromatography technique.
  
  
  RESULTS
  Three patients with bloodstream infection underwent CVVHD and three CVVHDF. CVVHDF patients had significantly lower mean AUC(0-24) and C(max)  values. A significant decrease in plasma levels was observed in a CVVHDF patient using 'high cut-off' hemofilters.
  
  
  CONCLUSIONS
  Increasing doses of daptomycin should be considered in critical patients, especially those undergoing CVVHDF.
authors.affiliation: Departmert of Public Health and Infectious Diseases, University of Rome ‘Sapienza’, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Falcone
authors.forename: Alessandro
authors.initials: A
authors.lastname: Russo
authors.forename: Maria Iris
authors.initials: MI
authors.lastname: Cassetta
authors.forename: Angela
authors.initials: A
authors.lastname: Lappa
authors.forename: Luigi
authors.initials: L
authors.lastname: Tritapepe
authors.forename: Stefania
authors.initials: S
authors.lastname: Fallani
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Vullo
authors.forename: Mario
authors.initials: M
authors.lastname: Venditti
authors.forename: Andrea
authors.initials: A
authors.lastname: Novelli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D017576:Daptomycin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006207:Half-Life; D017583:Hemodiafiltration; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D006435:Renal Dialysis; D013290:Streptococcal Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin