title: Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease.
abstract: BACKGROUND
  It has been recently demonstrated that Royal jelly (RJ) has a beneficial role on neural functions. Alzheimer's disease (AD) is associated with impairments of learning and memory. Therefore, the present study was designed to examine the effect of RJ on spatial learning and memory in rats after intracerebroventricular injection of streptozotocin (icv-STZ).
  
  
  METHODS
  Rats were infused bilaterally with an icv injection of STZ, while sham rats received vehicle only. The rats were feed with RJ-contained food (3% w/w) (lyophilized RJ mixed with powdered regular food) or regular food for 10 days. Then spatial learning and memory was tested in the rats by Morris water maze test.
  
  
  RESULTS
  Results showed that in icv-STZ group latency and path length were increased as compared to sham group, also icv-STZ rats less remembered the target quadrant that previously the platform was located; however, these were protected significantly in STZ group that received RJ-containing food.
  
  
  CONCLUSIONS
  Our findings support the potential neuroprotective role of RJ and its helpful effects in AD.
authors.affiliation: Applied Physiology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Zohre
authors.initials: Z
authors.lastname: Zamani
authors.forename: Parham
authors.initials: P
authors.lastname: Reisi
authors.forename: Hojjatallah
authors.initials: H
authors.lastname: Alaei
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Pilehvarian