title: Contact and fumigant toxicities of 3-methylphenol isolated from Ostericum koreanum and its derivatives against house dust mites.
abstract: The acaricidal activities of an active constituent derived from  Ostericum koreanum  roots and its derivatives were determined using fumigant and direct-contact toxicity bioassays against  Dermatophagoides farinae  and  Dermatophagoides pteronyssinus . This was compared with that of a commercial acaricide (benzyl benzoate). In the fumigant toxicity bioassay, 4-chloro-6-isopropyl-3-methylphenol (0.29 μg/cm(2)) was 37.17 times more effective than benzyl benzoate (10.78 μg/cm(2)) against D. farinae, followed by 6-fluoro-3-methylphenol (0.57 μg/cm(2)), 3-methylphenol (0.63 μg/cm(2)), 4-chloro-3-methylphenol (0.75 μg/cm(2)), and 4-isopropyl-3-methylphenol (0.78 μg/cm(2)). In the direct-contact toxicity bioassay, 4-chloro-6-isopropyl-3-methylphenol (0.21 μg/cm(2)) was 36.81 times more toxic than benzyl benzoate (7.73 μg/cm(2)) against D. farinae, followed by 6-fluoro-3-methylphenol (0.40 μg/cm(2)), 3-methylphenol (0.41 μg/cm(2)), 4-isopropyl-3-methylphenol (0.56 μg/cm(2)), and 4-chloro-3-methylphenol (0.60 μg/cm(2)). The acaricidal effects of 3-methyphenol derivatives against D. pteronyssinus were similar to those against D. farinae. In structure-activity relationships, acaricidal activities could be related to the introduction of chloro, fluoro, and isopropyl functional groups onto the 3-methylphenol skeleton. These results indicate that naturally occurring 3-methylphenol and its derivatives are potential house dust mite control agents.
authors.affiliation: Department of Bioenvironmental Chemistry, Chonbuk National University, Jeonju, Republic of Korea.
authors.forename: Ju-Hyun
authors.initials: JH
authors.lastname: Jeon
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Yang
authors.forename: Namhyun
authors.initials: N
authors.lastname: Chung
authors.forename: Hoi-Seon
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000818:Animals; D019661:Apiaceae / Q000737:chemistry*; D003408:Cresols / Q000737:chemistry / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D039981:Pyroglyphidae / Q000187:drug effects*
chemical_list: D003408:Cresols; D007306:Insecticides; D010936:Plant Extracts; C042041:3-cresol