title: An optimization-based design framework for steering steady states and improving robustness of glycolysis-glycogenolysis pathway.
abstract: A robust synthesis technique is devised for synergism and saturation systems, commonly known as S-systems, for controlling the steady states of the glycolysis-glycogenolysis pathway. The development of the robust biochemical network is essential owing to the fragile response to the perturbation of intrinsic and extrinsic parameters of the nominal S-system. The synthesis problem is formulated in a computationally attractive convex optimization framework. The linear matrix inequalities are framed to aim at the minimization of steady-state error, improvement of robustness, and utilization of minimum control input to the biochemical network.
authors.affiliation: Department of Electrical Engineering, Indian Institute of Technology, Kharagpur, West Bengal 721302, India. surajit.panja@gmail.com
authors.forename: Surajit
authors.initials: S
authors.lastname: Panja
authors.forename: Sourav
authors.initials: S
authors.lastname: Patra
authors.forename: Anirban
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Madhumita
authors.initials: M
authors.lastname: Basu
authors.forename: Sanghamitra
authors.initials: S
authors.lastname: Sengupta
authors.forename: Pranab K
authors.initials: PK
authors.lastname: Dutta
mesh_terms: D003198:Computer Simulation; D050261:Glycogenolysis; D006019:Glycolysis; D007700:Kinetics; D008954:Models, Biological; D012984:Software; D049490:Systems Biology / Q000379:methods