title: [Research on toxicity characteristics in Evodia Fructus of different orgins and producing areas].
abstract: OBJECTIVE
  To study the toxicity of water extracts from the fruits of Evodia Fructus in different producing areas.
  
  
  METHODS
  Compare the toxicity of the extracts from different Evodia Fructus on mice by the methods of acute and subacute toxicity test. The mice were given the extracts for 1 d to test the maximal tolerance dose (MTD) or maximal dose and observe the acute toxic symptoms; The mice were given the extracts for 15 d and then detected the level of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride (TG). The liver index was calculated, and the liver histological changes were investigated.
  
  
  RESULTS
  The MTD of water extracts from the fruits of Evodia Fructus is 62, 44.8, 35.84 g x kg(-1); the MTD of Evodia Fructus is 56, 44. 8, 35.84 g x kg(-1); the maximal dose of Evodia Fructus is 60, 54, 45 g x kg(-1). The toxic symptoms of the mice which had been given the nine samples were almost consistent. Compared with the control group in subacute toxicity test, the level of serum ALT and the liver index were all increased. The liver histological were changed.
  
  
  CONCLUSIONS
  When water extracts from the fruits of Evodia Fructus are given to mice one or more times. It may be toxic and induce liver damage. There is no significant correlation between the toxicity and Evodia orgins, while the toxicity seems to be more closely related to the producing area.
authors.affiliation: Sichuan Academy of Traditional Chinese Medicine Sciences, Traditional Chinese Medicine Quality of the Administration of Traditional Chinese Medicine, Sichuan Provincial Key Laboratory of the Quality and Innovation Research of Chinese Materia Medica, Chengdu 610041, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Junning
authors.initials: J
authors.lastname: Zhao
authors.forename: Jinhai
authors.initials: J
authors.lastname: Yi
authors.forename: Guangming
authors.initials: G
authors.lastname: Shu
authors.forename: Bo
authors.initials: B
authors.lastname: Li
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002681:China; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D032086:Evodia / Q000737:chemistry*; D005260:Female; D005638:Fruit / Q000737:chemistry; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D014280:Triglycerides / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D014280:Triglycerides; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase