title: Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis.
abstract: Four tetracyclic oxindole alkaloids, rhynchophylline, isorhynchophylline, corynoxine and corynoxine B were isolated from the hooks of Uncaria macrophylla Wall. (Rubiaceae), that is a dominant plant widely distributed in Yunnan province. These compounds exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice.
authors.affiliation: Tsumura Central Research Laboratories, Amimachi, Inashikigun, Ibaraki, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Sakakibara
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Terabayashi
authors.forename: M
authors.initials: M
authors.lastname: Yuzurihara
authors.forename: M
authors.initials: M
authors.lastname: Kubo
authors.forename: A
authors.initials: A
authors.lastname: Ishige
authors.forename: M
authors.initials: M
authors.lastname: Higuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Komatsu
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: M
authors.initials: M
authors.lastname: Maruno
authors.forename: C
authors.initials: C
authors.lastname: Biqiang
authors.forename: H X
authors.initials: HX
authors.lastname: Jiang