title: Consequences of direct and indirect activation of dendritic cells on antigen presentation: functional implications and clinical considerations.
abstract: The antigen presentation properties of Dendritic cells (DC) are key factors in the initiation and modulation of immune responses. The mechanisms involved in the regulation of MHC II antigen presentation in DC have been thoroughly investigated. Here, we will summarize recent advances in the field, focusing on how DC regulate antigen presentation during and after maturation, and its functional implications. We will also discuss future perspectives and clinical considerations.
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Javier
authors.initials: J
authors.lastname: Vega-Ramos
authors.forename: José A
authors.initials: JA
authors.lastname: Villadangos
mesh_terms: D017951:Antigen Presentation; D003713:Dendritic Cells / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D044767:Ubiquitin-Protein Ligases / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D000949:Histocompatibility Antigens Class II; C528121:MARCHF1 protein, human; D044767:Ubiquitin-Protein Ligases