title: Association of helicobacter pylori infection with severity of coronary heart disease.
abstract: BACKGROUND
  There are few literatures evaluating the association between cytotoxin-associated gene A (CagA) positive strains of Helicobacter pylori (HP) and the severity of coronary heart disease (CHD). This study was designed to investigate this association.
  
  
  METHODS
  Medical and drug history of 112 consecutive patients who were candidate for coronary angiography were taken. Fasting blood samples were obtained to measure C-reactive protein (CRP), anti Helicobacter pylori immunoglobulin G (anti-HP IgG), anti-CagA antibody (Ab) and interlukine-6 (IL6). According to angiography reports, participants were divided into patients with mild (n = 69) and with sever CHD (n = 36). To measure the association between CagA positive strains of HP with the severity of CHD, multivariate logistic regression tests were used by adjusting age, sex, history of diabetes mellitus (DM), dyslipidemia (DLP), and/or hypertension (HTN), CRP status and IL-6 level.
  
  
  RESULTS
  The analysis was concluded on 105 subjects. HP infection and CagA Ab were not significantly higher compared to the patients with severe and mild CHD (P = 0.28 and P = 0.68, respectively). Colonization of CagA positive HP did not significantly associate with severity of CHD (OR 1.05, 95% CI 0.33-3. 39).
  
  
  CONCLUSIONS
  Colonization of CagA positive HP was not an independent risk factor for severe coronary heart disease.
authors.affiliation: Assistant Professor, Department of Internal Medicine, Najafabad Branch, Islamic Azad University, Isfahan, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Rogha
authors.forename: Davood
authors.initials: D
authors.lastname: Dadkhah
authors.forename: Zahra
authors.initials: Z
authors.lastname: Pourmoghaddas
authors.forename: Keivan
authors.initials: K
authors.lastname: Shirneshan
authors.forename: Marjan
authors.initials: M
authors.lastname: Nikvarz
authors.forename: Masoud
authors.initials: M
authors.lastname: Pourmoghaddas