title: Outcome and incidence of re-intervention after surgical repair of tetralogy of fallot.
abstract: OBJECTIVE
  Timing of primary repair of tetralogy of Fallot (TOF) remains controversial. We evaluated the long-term outcome of early primary treatment strategy in a patient cohort with TOF less than eight months of age.
  
  
  METHODS
  A group of 120 patients with TOF less than eight months of age (5 ± 2.4 months) underwent early primary repair of TOF between October 1998 and August 2009. Sixty-one patients received a transanular (TAN) repair, and 59 patients received a right ventricular outflow tract (RVOT) + main pulmonary artery (MPA) double patch repair with concomitant pulmonary valve reconstruction.
  
  
  RESULTS
  There was no early or late mortality. The follow-up was 100% completed. There were eight reoperations and eight patients underwent catheter intervention for severe pulmonary valve insufficiency or stenosis, obstruction of right ventricular outflow tract, and stenosis of pulmonary arteries. Actuarial survival was 100% at ten years. At latest follow-up 80 patients were in NYHA Class I without any antiarrhythmic medications. On latest echocardiography, 90 (75%) patients had mild to moderate pulmonary regurgitation, and 10 had a right ventricular outflow tract gradient more than 40 mmHg.
  
  
  CONCLUSIONS
  These data strongly support the concept of early primary repair of TOF in patients with well developed pulmonary arteries. Early primary repair is associated with an excellent early and late outcomes, an acceptable risk of reoperation and re-intervention, and a low incidence of significant right ventricular dysfunction.
authors.affiliation: Department of Cardiac Surgery, University of Leipzig, Heart Centre, Leipzig, Germany. farhad@bakhtiary.de
authors.forename: Farhad
authors.initials: F
authors.lastname: Bakhtiary
authors.forename: Ingo
authors.initials: I
authors.lastname: Dähnert
authors.forename: Sergey
authors.initials: S
authors.lastname: Leontyev
authors.forename: Thomas
authors.initials: T
authors.lastname: Schröter
authors.forename: Jörg
authors.initials: J
authors.lastname: Hambsch
authors.forename: Friedrich Wilhelm
authors.initials: FW
authors.lastname: Mohr
authors.forename: Martin
authors.initials: M
authors.lastname: Kostelka
mesh_terms: D006348:Cardiac Surgical Procedures / Q000379:methods; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D011651:Pulmonary Artery; D012086:Reoperation / Q000706:statistics & numerical data*; D013771:Tetralogy of Fallot / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000453:epidemiology