title: Systematic lymphadenectomy in patients with clinical stage II endometrial carcinoma: a case report and review of the literature.
abstract: OBJECTIVE
  The aim of this case report and review of the literature was to evaluate the effect of adding pelvic and/or para-aortic lymphadenectomy to hysterectomy and bilateral salpingo-oophorectomy (BSO) on the five year recurrence-free survival in patients with clinical Stage II endometrial carcinoma.
  
  
  METHODS
  A Pubmed, Embase, and Cochrane library search was performed to identify relevant articles. After screening, using predetermined exclusion and inclusion criteria, and critical appraisal, a final of four articles remained.
  
  
  RESULTS
  This search only revealed studies with a retrospective design. Two articles showed a significant disease-specific survival benefit in patients undergoing systematic lymphadenectomy for Stage II endometrial carcinoma. In multivariate analyses, conducted in both studies, this improvement in survival was also evident (HR 0.75, 95% CI 0.69 - 0.81, p < 0.001 and HR 0.74, 95% CI 0.58 - 0.93, p = 0.0096). The remaining studies revealed a non-significant ten-year recurrence-free survival (77% vs 65%) and five-year overall survival (72% vs 70%) in favour of patients undergoing systematic lymphadenectomy.
  
  
  CONCLUSIONS
  The practise of performing a systematic lymphadenectomy in patients with clinical Stage II endometrial carcinoma as advocated in guidelines, is not based on evidence from randomised clinical trials. However, lymph node dissection seems to improve the five-year disease-specific survival in retrospective studies.
authors.affiliation: Department of Obstetrics and Gynecology, St. Antonius Hospital, Nieuwegein; Diakonessen Hospital, Utrecht, The Netherlands.
authors.forename: T N
authors.initials: TN
authors.lastname: Schuurman
authors.forename: A
authors.initials: A
authors.lastname: Stiekema
authors.forename: J H
authors.initials: JH
authors.lastname: Schagen van Leeuwen
authors.forename: R H M
authors.initials: RH
authors.lastname: Verheijen
mesh_terms: D000368:Aged; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D009367:Neoplasm Staging