title: Vitamin D interactions with soy isoflavones on bone after menopause: a review.
abstract: Vitamin D is known to increase Ca absorption in adults. However, the threshold vitamin D status to benefit Ca absorption is lower than the target vitamin D status for higher bone mineral density and lower fracture risk, pointing to another pathway for vitamin D to benefit bone. One possibility is by affecting osteoblast and osteoclasts directly. Vitamin D-related bone metabolism may also be affected by soy isoflavones, which selectively bind to the estrogen receptor &#946; and may reduce bone loss in postmenopausal women. We discuss a possible synergistic effect of soy isoflavones and vitamin D on bone by affecting osteoblast and osteoclast formation and activity in postmenopausal women.
authors.affiliation: Department of Nutrition Science, Purdue University, 700 W State St, West Lafayette, IN 47907, USA. cypark@purdue.edu
authors.forename: Clara Y
authors.initials: CY
authors.lastname: Park
authors.forename: Connie M
authors.initials: CM
authors.lastname: Weaver
mesh_terms: D000042:Absorption / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D004357:Drug Synergism; D005260:Female; D019833:Genistein / Q000008:administration & dosage; D006620:Hip Fractures; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D048789:Phytoestrogens / Q000008:administration & dosage; D017698:Postmenopause; D012307:Risk Factors; D013025:Glycine max / Q000737:chemistry*; D014807:Vitamin D / Q000008:administration & dosage*
chemical_list: D007529:Isoflavones; D048789:Phytoestrogens; D014807:Vitamin D; C004742:daidzein; D019833:Genistein; D002118:Calcium