title: Gold-catalyzed reactions of 3-alkynyloxireno[2, 3-b]chromenones to form 3(2H)-furanones via a domino pathway.
abstract: 3(2H)-Furanones are efficiently generated from 3-alkynyl oxireno[2,3-b]chromenones by an Au/DDQ-catalyzed domino reaction through a pathway composed of cyclization, C-C cleavage, nucleophilic addition, oxidation, and nucleophilic addition. It was found that stoichiometric AuCl(3) or catalytic Au with stoichiometric DDQ can oxidize the benzylic sp(3) C-H bond to facilitate nucleophilic addition.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Hu
authors.forename: Jianwei
authors.initials: J
authors.lastname: Yan
authors.forename: Ming
authors.initials: M
authors.lastname: Cheng
authors.forename: Youhong
authors.initials: Y
authors.lastname: Hu
mesh_terms: D001578:Benzopyrans / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D005663:Furans / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D001578:Benzopyrans; D005663:Furans; D006046:Gold