title: Diversity-oriented enantioselective synthesis of highly functionalized cyclic and bicyclic alcohols.
abstract: The copper-catalyzed hetero-allylic asymmetric alkylation (h-AAA) of functionalized Grignard reagents that contain alkene or alkyne moieties has been achieved with excellent regio- and enantioselectivity. The corresponding alkylation products were further transformed into a variety of highly functionalized cyclic and bicyclic alcohols with excellent control over the chemo-, regio-, and stereoselectivity.
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Bin
authors.initials: B
authors.lastname: Mao
authors.forename: Martín
authors.initials: M
authors.lastname: Fañanás-Mastral
authors.forename: Martin
authors.initials: M
authors.lastname: Lutz
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000438:Alcohols