title: Functional neuronal activity and connectivity within the subthalamic nucleus in Parkinson's disease.
abstract: OBJECTIVE
  Characterization of the functional neuronal activity and connectivity within the subthalamic nucleus (STN) in patients with Parkinson's disease (PD).
  
  
  METHODS
  Single units were extracted from micro-electrode recording (MER) of 18 PD patients who underwent STN deep brain stimulation (DBS) surgery. The firing rate and pattern of simultaneously recorded spike trains and their coherence were analyzed. To provide a precise functional assignment of position to the observed activities, for each patient we mapped its classified multichannel STN MERs to a generic atlas representation with a sensorimotor part and a remaining part.
  
  
  RESULTS
  Within the sensorimotor part we found significantly higher mean firing rate (P < 0.05) and significantly more burst-like activity (P < 0.05) than within the remaining part. The proportion of significant coherence in the beta band (13-30 Hz) is significantly higher in the sensorimotor part of the STN than elsewhere (P = 0.015).
  
  
  CONCLUSIONS
  The STN sensorimotor part distinguishes itself from the remaining part with respect to beta coherence, firing rate and burst-like activity and postoperatively was found as the preferred target area.
  
  
  CONCLUSIONS
  Our firing behavior analysis may help to discriminate the STN sensorimotor part for the placement of the DBS electrode.
authors.affiliation: Department of Applied Mathematics, University of Twente, 7500 AE Enschede, The Netherlands. m.a.j.lourens@utwente.nl
authors.forename: M A J
authors.initials: MA
authors.lastname: Lourens
authors.forename: H G E
authors.initials: HG
authors.lastname: Meijer
authors.forename: M F
authors.initials: MF
authors.lastname: Contarino
authors.forename: P
authors.initials: P
authors.lastname: van den Munckhof
authors.forename: P R
authors.initials: PR
authors.lastname: Schuurman
authors.forename: S A
authors.initials: SA
authors.lastname: van Gils
authors.forename: L J
authors.initials: LJ
authors.lastname: Bour
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008839:Microelectrodes; D008875:Middle Aged; D009474:Neurons / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000503:physiopathology* / Q000601:surgery; D016896:Treatment Outcome