title: PDGF α receptor is a mediator for Cisplatin-induced Met expression.
abstract: For decades, platinum drugs have been the mainstay of cancer treatment. However, over time, drug resistance develops, leaving few treatment options. Here we show that platelet-derived growth factor α receptor (PDGF α receptor)-mediated signaling plays a key role in hepatocyte growth factor (HGF) receptor (c-Met) upregulation, which in turn is thought to play an important role in chemotherapy resistance. PDGF α receptor inhibition eliminates cisplatin-dependent Met expression in cervical cancer cell lines. PDGF α receptor inhibitors are widely used in clinical settings, suggesting that the clinical translation of our findings could reduce the suffering of people from drug resistance.
authors.affiliation: Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kina
authors.forename: Thongsavanh
authors.initials: T
authors.lastname: Phonaphonh
authors.forename: Feixin
authors.initials: F
authors.lastname: Liang
authors.forename: Hai
authors.initials: H
authors.lastname: Kuang
authors.forename: Akira
authors.initials: A
authors.lastname: Arasaki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Arakaki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nakasone
authors.forename: Hajime
authors.initials: H
authors.lastname: Sunakawa
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction; D015854:Up-Regulation / Q000187:drug effects; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D019859:Proto-Oncogene Proteins c-met; D020796:Receptor, Platelet-Derived Growth Factor alpha; D002945:Cisplatin