title: The antiinflammatory and liver protective effects of Boehmeria nivea and B. nivea subsp. nippononivea in rats.
abstract: The pharmacological effects of Boehmeria nivea and B. nivea subsp. nippononivea were studied against carrageenan-induced paw edema, acetaminophen (APAP) and D-galactosamine (D-GalN) induced hepatotoxicity in rats, respectively. Water extracts of B. nivea and B. nivea subsp. nippononivea roots were found to maintain significant antiinflammatory activity against carrageenan-induced edema. Moreover, the water extracts of B. nivea and B. nivea subsp. nippononivea significantly decreased the acute increase in serum GOT and GPT levels caused by APAP and D-GalN-intoxication. The histopathological changes of hepatic lesions caused by these hepatotoxicants were improved by treatment with B. nivea and B. nivea subsp. nippononivea, which were compared with Silymarin as a standard.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical College, Kaohsiung, Taiwan, R.O.C.
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
authors.forename: M H
authors.initials: MH
authors.lastname: Yen
authors.forename: T S
authors.initials: TS
authors.lastname: Lo
authors.forename: C F
authors.initials: CF
authors.lastname: Lin