title: Autworks: a cross-disease network biology application for Autism and related disorders.
abstract: BACKGROUND
  The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology of autism, but there are few tools that enable us to conduct cross-disorder analysis and to visualize the results.
  
  
  METHODS
  We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders. Users may examine the structure of gene interactions within a set of disorder-associated genes, compare networks of disorder/disease genes with those of other disorders/diseases, and upload their own sets for comparative analysis.
  
  
  CONCLUSIONS
  Autworks is a web application that provides an easy-to-use resource for researchers of varied backgrounds to analyze the autism gene network structure within and between disorders.
  
  
  BACKGROUND
  http://autworks.hms.harvard.edu/
authors.affiliation: The Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Tristan H
authors.initials: TH
authors.lastname: Nelson
authors.forename: Jae-Yoon
authors.initials: JY
authors.lastname: Jung
authors.forename: Todd F
authors.initials: TF
authors.lastname: Deluca
authors.forename: Byron K
authors.initials: BK
authors.lastname: Hinebaugh
authors.forename: Kristian Che
authors.initials: KC
authors.lastname: St Gabriel
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Wall
mesh_terms: D001321:Autistic Disorder / Q000235:genetics*; D030541:Databases, Genetic; D053263:Gene Regulatory Networks / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D020407:Internet