title: Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation.
abstract: Formyl Peptide Receptors (FPRs) are vital in the host inflammatory response, playing an important regulatory role in multiple diseases. A Gd(III) DOTA conjugate of cFLFLFK has been synthesised which targets and visualises FPR1 upon leukocytes in the inflammatory response via magnetic resonance imaging for the first time.
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
authors.forename: Graeme J
authors.initials: GJ
authors.lastname: Stasiuk
authors.forename: Helen
authors.initials: H
authors.lastname: Smith
authors.forename: Marzena
authors.initials: M
authors.lastname: Wylezinska-Arridge
authors.forename: Jordi L
authors.initials: JL
authors.lastname: Tremoleda
authors.forename: William
authors.initials: W
authors.lastname: Trigg
authors.forename: Sajinder Kaur
authors.initials: SK
authors.lastname: Luthra
authors.forename: Veronique
authors.initials: V
authors.lastname: Morisson Iveson
authors.forename: Felicity N E
authors.initials: FN
authors.lastname: Gavins
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Long
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D007477:Ions / Q000737:chemistry; D007962:Leukocytes / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D051379:Mice; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D011859:Radiography; D044042:Receptors, Formyl Peptide / Q000737:chemistry / Q000378:metabolism*
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D006573:Heterocyclic Compounds, 1-Ring; D007477:Ions; D009842:Oligopeptides; D044042:Receptors, Formyl Peptide; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D005682:Gadolinium