title: Two novel hydroperoxylated products of 20(S)-protopanaxadiol produced by Mucor racemosus and their cytotoxic activities against human prostate cancer cells.
abstract: Microbial transformation of 20(S)-protopanaxadiol (1) by Mucor racemosus AS 3.205 yielded two novel hydroperoxylated metabolites and three known hydroxylated metabolites. The structures of the metabolites were identified as 26-hydroxyl-20(S)-protopanaxadiol (2), 23,24-en-25-hydroxyl-20(S)-protopanaxadiol (3), 25,26-en-24(R)-hydroperoxyl-20(S)-protopanaxadiol (4), 23,24-en-25-hydroperoxyl-20(S)-protopanaxadiol (5), and 25-hydroxyl-20(S)-protopanaxadiol (6). 4 and 5 are new compounds. Metabolites 2, 4, and 5 showed the more potent inhibitory effects against DU-145 and PC-3 cell lines than the substrate.
authors.affiliation: School of Medicine, Nantong University, Nantong 226001, People's Republic of China. guangtong_chen@163.com
authors.forename: Guangtong
authors.initials: G
authors.lastname: Chen
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.forename: Shaojun
authors.initials: S
authors.lastname: Nong
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Bohui
authors.initials: B
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001711:Biotransformation; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*; D011471:Prostatic Neoplasms; D012502:Sapogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D012502:Sapogenins; C062916:protopanaxadiol