title: Protein Arginine Methyltransferases (PRMTs): promising targets for the treatment of pulmonary disorders.
abstract: Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products originating from protein arginine methylation that influence nitric oxide (NO)-dependent processes. A growing body of evidence suggests that both mechanisms are implicated in cardiovascular and pulmonary diseases. This review will present and discuss recent research on PRMTs and the methylation of non-histone proteins and its consequences for the pathogenesis of various lung disorders, including lung cancer, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease and asthma. This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany. dariusz.zakrzewicz@innere.med.uni-giessen.de.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Zakrzewicz
authors.forename: Anna
authors.initials: A
authors.lastname: Zakrzewicz
authors.forename: Klaus T
authors.initials: KT
authors.lastname: Preissner
authors.forename: Philipp
authors.initials: P
authors.lastname: Markart
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wygrecka
mesh_terms: D000818:Animals; D001249:Asthma / Q000201:enzymology / Q000473:pathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000201:enzymology / Q000473:pathology; D008171:Lung Diseases / Q000201:enzymology* / Q000473:pathology; D008175:Lung Neoplasms / Q000201:enzymology / Q000473:pathology; D011499:Protein Processing, Post-Translational; D011484:Protein-Arginine N-Methyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000201:enzymology / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000201:enzymology / Q000473:pathology
chemical_list: D011484:Protein-Arginine N-Methyltransferases