title: [Mechanisms and effects of Abelmoschus manihot preparations in treating chronic kidney disease].
abstract: Abelmoschus manihot (AM) is a medicinal plant rich in twenty kinds of separated active bio-components including flavones, polysaccharides, trannic acid, and long chain hydrocarbons. Among these, total flavones of A. manihot (TFA) are the major active component. In this review, the mechanisms of Huangkui capsule will be discussed as a preparation of AM to treat chronic kidney disease (CKD) by improving immunological reaction, inflammation, renal fibrosis, and renal tubular epithelial injury. Additionally, it has been reported that Huangkui capsule can ameliorate some clinical symptoms, proteinuria, hematuria, and renal function in patients with common CKD, such as nephrotic syndrome, diabetic nephropathy, Henoch-Schönlein purpura nephritis, IgA nephropathy, and membranous nephropathy.
authors.affiliation: Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. meisu1990@126.com
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Yigang
authors.initials: Y
authors.lastname: Wan
authors.forename: Chaojun
authors.initials: C
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.forename: Qingxue
authors.initials: Q
authors.lastname: Wei
authors.forename: Yue
authors.initials: Y
authors.lastname: Tu
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Yin
mesh_terms: D028483:Abelmoschus / Q000737:chemistry*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal