title: Synchronous metastasis from lobular carcinoma and primary carcinoma of the endometrium in a patient after tamoxifen therapy.
abstract: Patients treated with tamoxifen often experience vaginal bleeding, generally because of benign endometrial lesions or, less often, because of endometrial carcinoma. A rare cause of vaginal bleeding in these patients is breast carcinoma metastasis in an endometrial polyp. We describe a 67-yr-old patient with metastasis of lobular breast carcinoma in an endometrial polyp and papillary serous endometrial carcinoma, both diagnosed simultaneously in a uterine curettage. The coexistence of the 2 cancers was confirmed by pathologic study of the hysterectomy specimen. To our knowledge, this is the first reported case of the synchronous presence of the 2 neoplastic diseases. Endometrial biopsies performed for endometrial disorders in patients who have breast cancer and have received tamoxifen should be studied carefully to avoid underdiagnosis.
authors.affiliation: Department of Pathology, Hospital Universitario Virgen de la Victoria, Malaga, Spain. vicioso@uma.es
authors.forename: Luis
authors.initials: L
authors.lastname: Vicioso
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Ortega
authors.forename: Vicente
authors.initials: V
authors.lastname: Cívico
authors.forename: Antonio
authors.initials: A
authors.lastname: López-Beltrán
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000188:drug therapy / Q000556:secondary*; D018283:Cystadenocarcinoma, Papillary / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000473:pathology; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000556:secondary*; D005260:Female; D006801:Humans; D016609:Neoplasms, Second Primary / Q000473:pathology*; D011127:Polyps / Q000473:pathology; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen