title: Sirolimus therapy may cause cardiac tamponade.
abstract: The side-effects associated with the immunosuppressive drug sirolimus are numerous and constitute a major limitation for its use in renal transplantation. In this study, we describe two cases of renal transplant recipients treated with sirolimus who developed pericardial tamponade associated with interstitial pneumonia, proteinuria, microcytic anemia and, in one case, lymphocytic meningitidis. An extensive search for infectious agents was negative, and all symptoms disappeared after sirolimus interruption. Therefore, this case demonstrates for the first time that sirolimus can cause pericardial tamponade as well as lymphocytic meningitidis.
authors.affiliation: Service de Transplantation Rénale et Soins Intensifs, Hôpital Necker, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Bertrand
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Desbuissons
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pallet
authors.forename: Alain
authors.initials: A
authors.lastname: Debure
authors.forename: Albane
authors.initials: A
authors.lastname: Sartorius
authors.forename: Dany
authors.initials: D
authors.lastname: Anglicheau
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Mamzer
authors.forename: Christophe
authors.initials: C
authors.lastname: Legendre
authors.forename: Rebecca
authors.initials: R
authors.lastname: Sberro-Soussan
mesh_terms: D000368:Aged; D002305:Cardiac Tamponade / Q000139:chemically induced* / Q000209:etiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008581:Meningitis / Q000209:etiology; D008875:Middle Aged; D010490:Pericardial Effusion / Q000209:etiology; D020123:Sirolimus / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus