title: Cell-specific intracellular anticancer drug delivery from mesoporous silica nanoparticles with pH sensitivity.
abstract: A nanoreservoir for efficient intracellular anticancer drug delivery based on mesoporous silica nanoparticles end-capped with lactobionic acid-grafted bovine serum albumin is fabricated. It demonstrates great potential for both cell-specific endocytosis and intracellular pH-responsive controlled release of drugs. A possible endocytosis pathway/mechanism of the smart controlled drug release system is proposed.
authors.affiliation: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR of China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Luo
authors.forename: Kaiyong
authors.initials: K
authors.lastname: Cai
authors.forename: Yan
authors.initials: Y
authors.lastname: Hu
authors.forename: Beilu
authors.initials: B
authors.lastname: Zhang
authors.forename: Dawei
authors.initials: D
authors.lastname: Xu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004187:Disaccharides / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D016062:Porosity; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013347:Subcellular Fractions / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004187:Disaccharides; D053769:Nanocapsules; D012710:Serum Albumin, Bovine; C005608:lactobionic acid; D012822:Silicon Dioxide; D004317:Doxorubicin