title: Novel analytical methods for stratus OCT: alignment of the scan circle.
abstract: Measurement of retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) is commonly used in the detection and management of glaucoma. The Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA) is widely used, but image acquisition is subject to artifacts, such as those caused by normal fixational eye movements, and this leads to unreliable measurements. Novel analytical methods have been developed to estimate the amount of misalignment of the circular scanning protocol used by the Stratus OCT. A computer program with a graphical user interface implementing these methods has been written by some of the authors. A case example is presented in this report that shows the effect that vertical displacements of the OCT scan have on measured RNFL thickness. The example is used to demonstrate how the software can be used for estimating the positional alignment of the scan circle. This software can potentially improve the identification of unreliable RNFL thickness measurements and is freely available from the authors.
authors.affiliation: Indiana University School of Optometry, Bloomington, Indiana 47405, USA. imarinfr@indiana.edu
authors.forename: Iván
authors.initials: I
authors.lastname: Marín-Franch
authors.forename: William H
authors.initials: WH
authors.lastname: Swanson
authors.forename: Brittany R
authors.initials: BR
authors.lastname: Adams
authors.forename: Haogang
authors.initials: H
authors.lastname: Zhu
authors.forename: David P
authors.initials: DP
authors.lastname: Crabb
mesh_terms: D005189:False Positive Reactions; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D009412:Nerve Fibers / Q000473:pathology*; D011237:Predictive Value of Tests; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*