title: Changes and significance of serum angiopoietin-2 levels in patients with coronary heart disease.
abstract: Coronary heart disease (CHD) is characterized by inflammatory process and endothelial dysfunction. To investigate angiopoietin-2 (Ang-2) profiles, we evaluated serum Ang-2 levels in different types of CHD in 166 subjects. Ang-2 was measured by enzyme-linked immunosorbent assay. Serum Ang-2 levels were significantly elevated in patients with CHD and gradually increased with advance of CHD. Ang-2 was positively correlated with Gensini scores and hs-CRP. Ang-2 might have potential implication in detecting and monitoring the progression of CHD.
authors.affiliation: Department of Cardiology, Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Huijuan
authors.initials: H
authors.lastname: Yong
authors.forename: Lin
authors.initials: L
authors.lastname: Mi
authors.forename: Yun
authors.initials: Y
authors.lastname: Bai
authors.forename: Lijun
authors.initials: L
authors.lastname: Guo
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Ming
authors.initials: M
authors.lastname: Cui
authors.forename: Yongzhen
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D042702:Angiopoietin-2 / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood* / Q000175:diagnosis; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D042702:Angiopoietin-2; D015415:Biomarkers; D002097:C-Reactive Protein