title: Acute and chronic consequences of polidocanol foam injection in the lung in experimental animals.
abstract: OBJECTIVE
  To assess the presence of pulmonary embolism and inflammation after polidocanol foam injection into the peripheral veins of rabbits.
  
  
  METHODS
  The animals were treated with polidocanol foam (1 or 3 mg/kg) or vehicle. Early (15 minutes) and late (30 days) animals were evaluated by perfusional lung scintigraphy and histopathological examination.
  
  
  RESULTS
  In the control group no alterations were found. After polidocanol foam injection it was observed that an important reduction of pulmonary perfusion in the early periods, was mainly in the left lung (P < 0.001), with consequent embolism in the histological evaluation. In late periods it was observed that the presence of thrombus was with fibrin in small veins, compatible with chronic thrombus and the presence of chronic pulmonary inflammation.
  
  
  CONCLUSIONS
  The injection of polidocanol foam in experimental animals can induce venous embolism and chronic inflammatory infiltration.
authors.affiliation: Laboratório de Fisiopatologia Experimental, PPGCS, UNASAU, Universidade do Extremo Sul Catarinense, Criciúma, SC, 88806-000, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Grandi
authors.forename: R A
authors.initials: RA
authors.lastname: Grandi
authors.forename: C D
authors.initials: CD
authors.lastname: Tomasi
authors.forename: J L
authors.initials: JL
authors.lastname: da Rocha
authors.forename: V
authors.initials: V
authors.lastname: Cardoso
authors.forename: F
authors.initials: F
authors.lastname: Dal-Pizzol
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D005260:Female; D008168:Lung / Q000098:blood supply* / Q000473:pathology*; D008297:Male; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000009:adverse effects* / Q000494:pharmacology; D011655:Pulmonary Embolism / Q000139:chemically induced* / Q000473:pathology*; D011817:Rabbits; D012597:Sclerosing Solutions / Q000009:adverse effects* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D012597:Sclerosing Solutions; D000077423:Polidocanol; D011092:Polyethylene Glycols