title: No diagnostic value of plasma clusterin in Alzheimer's disease.
abstract: There is an urgent need for biomarkers to enable early diagnosis of Alzheimer's disease (AD). It has recently been shown that a variant within the clusterin gene is associated with increased risk of AD and plasma levels of clusterin have been found to be associated with the risk of AD. We, therefore, investigated the diagnostic value of clusterin by quantifying clusterin using an ELISA in plasma from 171 controls, 127 patients with AD, 82 patients with other dementias and 30 patients with depression. We observed similar plasma clusterin levels in controls, AD patients and patients with other dementias, suggesting that plasma clusterin levels have no diagnostic value for AD. There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation.
authors.affiliation: Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden. Edina.Silajdzic@med.lu.se
authors.forename: Edina
authors.initials: E
authors.lastname: Silajdžić
authors.forename: Lennart
authors.initials: L
authors.lastname: Minthon
authors.forename: Maria
authors.initials: M
authors.lastname: Björkqvist
authors.forename: Oskar
authors.initials: O
authors.lastname: Hansson
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D051152:Clusterin / Q000097:blood*; D003704:Dementia / Q000097:blood / Q000175:diagnosis; D003863:Depression / Q000097:blood / Q000175:diagnosis; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D012306:Risk; D013548:Sweden
chemical_list: D015415:Biomarkers; D051152:Clusterin