title: Computed tomography and magnetic resonance imaging of adult renal cell carcinoma associated with Xp11.2 translocation.
abstract: OBJECTIVE
  This study aimed to report the computed tomography (CT) and magnetic resonance imaging (MRI) findings of renal cell carcinoma associated with Xp11.2 translocation in adults.
  
  
  METHODS
  We retrospectively identified 9 adults with renal cell carcinoma associated with Xp11.2 translocation who underwent baseline cross-sectional imaging with CT (n = 9) or MRI (n = 3). All available clinical, imaging, and histopathological records were reviewed.
  
  
  RESULTS
  Mean patient age was 24 years (range, 18-45 years). Eight of 9 cancers demonstrated imaging findings of hemorrhage or necrosis (n = 3), advanced stage disease (n = 2), or both (n = 3) at CT or MRI.
  
  
  CONCLUSIONS
  The possibility of renal cell carcinoma associated with Xp11.2 translocation should be considered for a renal mass seen in a patient 45 years or younger, which demonstrates hemorrhage or necrosis or advanced stage disease at CT or MRI.
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
authors.forename: Trien T
authors.initials: TT
authors.lastname: Dang
authors.forename: Etay
authors.initials: E
authors.lastname: Ziv
authors.forename: Stefanie
authors.initials: S
authors.lastname: Weinstein
authors.forename: Maxwell V
authors.initials: MV
authors.lastname: Meng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Fergus V
authors.initials: FV
authors.lastname: Coakley
mesh_terms: D000293:Adolescent; D000328:Adult; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000235:genetics; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007472:Iohexol; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000235:genetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012189:Retrospective Studies; D036542:Tomography, Spiral Computed / Q000379:methods*; D014178:Translocation, Genetic / Q000235:genetics*; D055815:Young Adult
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D003287:Contrast Media; C069203:TFE3 protein, human; D007472:Iohexol; C064925:gadodiamide; D019786:Gadolinium DTPA