title: In vivo optical coherence tomography: the role of the pathologist.
abstract: Optical coherence tomography (OCT) is a nondestructive, high-resolution imaging modality, providing cross-sectional, architectural images at near histologic resolutions, with penetration depths up to a few millimeters. Optical frequency domain imaging is a second-generation OCT technology that has equally high resolution with significantly increased image acquisition speeds and allows for large area, high-resolution tissue assessments. These features make OCT and optical frequency domain imaging ideal imaging techniques for surface and endoscopic imaging, specifically when tissue is unsafe to obtain and/or suffers from biopsy sampling error. This review focuses on the clinical impact of OCT in coronary, esophageal, and pulmonary imaging and the role of the pathologist in interpreting high-resolution OCT images as a complement to standard tissue pathology.
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Boston, USA. lhariri@partners.org
authors.forename: Lida P
authors.initials: LP
authors.lastname: Hariri
authors.forename: Mari
authors.initials: M
authors.lastname: Mino-Kenudson
authors.forename: Eugene J
authors.initials: EJ
authors.lastname: Mark
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Suter
mesh_terms: D000818:Animals; D003327:Coronary Disease / Q000175:diagnosis* / Q000473:pathology; D057510:Endovascular Procedures; D004935:Esophageal Diseases / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis* / Q000473:pathology; D010338:Pathology, Clinical; D024382:Professional Role; D041623:Tomography, Optical Coherence / Q000379:methods*; D000078329:Workforce