title: Ramariolides A-D, antimycobacterial butenolides isolated from the mushroom Ramaria cystidiophora.
abstract: Four butenolides, ramariolides A-D (1-4), have been isolated from the fruiting bodies of the coral mushroom Ramaria cystidiophora. Their structures were elucidated by analysis of 1D and 2D NMR data and a single-crystal X-ray diffraction analysis of 1, and their absolute configurations were established using Mosher's method. The major metabolite, ramariolide A (1), which contains an unusual spiro oxiranebutenolide moiety, showed in vitro antimicrobial activity against Mycobacterium smegmatis and Mycobacterium tuberculosis.
authors.affiliation: Departments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Centko
authors.forename: Santiago
authors.initials: S
authors.lastname: Ramón-García
authors.forename: Terry
authors.initials: T
authors.lastname: Taylor
authors.forename: Brian O
authors.initials: BO
authors.lastname: Patrick
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Thompson
authors.forename: Vivian P
authors.initials: VP
authors.lastname: Miao
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000150:Acinetobacter / Q000187:drug effects; D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; C004511:butenolide; D015107:4-Butyrolactone