title: CYP11B2 T-344C gene polymorphism and atrial fibrillation: a meta-analysis of 2,758 subjects.
abstract: BACKGROUND
  Aldosterone synthase (CYP11B2) T-344C gene polymorphism was found to be correlated with atrial fibrillation (AF) risk. However, the results of individual studies remain conflicting.
  
  
  OBJECTIVE
  A meta-analysis including 2,758 subjects from six individual studies was performed to explore the correlation between CYP11B2 T-344C gene polymorphisms and AF. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by the fixed- or random-effects model.
  
  
  RESULTS
  A significant relationship between CYP11B2 T-344C gene polymorphism and AF was found under allelic (OR: 1.26, 95% CI: 1.11-1.42, P = 0.0002), recessive (OR: 1.99, 95% CI: 1.26-3.14, P = 0.003), dominant (OR: 0.903, 95% CI: 0.820-0.994, P = 0.036), homozygous (OR: 1.356, 95% CI: 1.130-1.628, P = 0.001), and additive (OR: 1.153, 95% CI: 1.070-1.243, P = 1.0×10(-10)) genetic models. No significant association between CYP11B2 T-344C gene polymorphism and AF was found under the heterozygous genetic model (OR: 1.040, 95% CI: 0.956-1.131, P = 0.361).
  
  
  CONCLUSIONS
  A significant association was found between CYP11B2 T-344C gene polymorphism and AF risk. Individuals with the C allele of CYP11B2 T-344C gene polymorphism have higher risk for AF.
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. lyynjmu123@126.com
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Li
authors.forename: Chuan-wei
authors.initials: CW
authors.lastname: Zhou
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Yun
authors.initials: Y
authors.lastname: Qian
authors.forename: Bei
authors.initials: B
authors.lastname: Wang
mesh_terms: D001281:Atrial Fibrillation / Q000235:genetics*; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D019405:Cytochrome P-450 CYP11B2