title: Hybrid conducting polymer-hydrogel conduits for axonal growth and neural tissue engineering.
abstract: Successfully and efficiently bridging peripheral nerve gaps without the use of autografts is a substantial clinical advance for peripheral nerve reconstructions. Novel templating methods for the fabrication of conductive hydrogel guidance channels for axonal regeneration are designed and developed. PEDOT is electrodeposited inside the lumen to create fully coated-PEDOT agarose conduits and partially coated-PEDOT agarose conduits.
authors.affiliation: Department of Bioengineering, Pennsylvania State University, University Park, PA 16802, USA. mabidian@psu.edu
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Abidian
authors.forename: Eugene D
authors.initials: ED
authors.lastname: Daneshvar
authors.forename: Brent M
authors.initials: BM
authors.lastname: Egeland
authors.forename: Daryl R
authors.initials: DR
authors.lastname: Kipke
authors.forename: Paul S
authors.initials: PS
authors.lastname: Cederna
authors.forename: Melanie G
authors.initials: MG
authors.lastname: Urbanchek
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D049108:Cell Enlargement; D048091:Guided Tissue Regeneration / Q000379:methods; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D009416:Nerve Regeneration / Q000502:physiology*; D020427:Peroneal Neuropathies / Q000473:pathology / Q000601:surgery*; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D054457:Tissue Scaffolds
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D020100:Hydrogels; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene)