title: Inflammatory status hepatic enzymes and serum creatinine in HIV-, HIV+ and HIV-TB co-infected adult Central Africans.
abstract: OBJECTIVE
  Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome is a major public health issue in Africa. The objective of this study was to determine which of isolated HIV-infection, isolated naive pulmonary tuberculosis (PTB), or naive HIV-PTB coinfection was more harmful to inflammatory, hepatic, and renal functions.
  
  
  METHODS
  This cross-sectional study was undertaken among ten patients with isolated HIV infection, ten patients with isolated naive HIV infection, ten patients with isolated PTB and 32 patients with HIV-PTB coinfection, with the aim of determining which group had the highest levels of oxidative stress and hepatic and renal dysfunction markers. Serum aminotransferase (AST), alanine transferase (ALT), gamma-glutamyl transferase (GGT), and creatinine measurements were compared across the three groups of patients, who were managed from admission in the pulmonology division of the Brazzaville Teaching Hospital, Congo.
  
  
  RESULTS
  HIV patients had the highest levels of ALT, GGT, and creatinine before and after adjusting for age and sex. Adjusted levels of AST, ALT, GGT, and creatinine were higher in HIV-PTB coinfection patients than in sero-negative PTB patients.
  
  
  CONCLUSIONS
  There is a significant association between HIV infection and increase in concentration of ALT, GGT, and creatinine.
authors.affiliation: Laboratory de Biochemistry-Pharmacology, Faculty of Health Sciences, Brazzaville, Congo ; National Laboratory of Public Health, Brazzaville, Congo.
authors.forename: Etienne
authors.initials: E
authors.lastname: Mokondjimobe
authors.forename: Benjamin
authors.initials: B
authors.lastname: Longo-Mbenza
authors.forename: Patou
authors.initials: P
authors.lastname: Mampouya-Arrouse
authors.forename: Henri Joseph
authors.initials: HJ
authors.lastname: Parra
authors.forename: Martin
authors.initials: M
authors.lastname: Diatewa