title: Hierarchical fibrillar scaffolds obtained by non-conventional layer-by-layer electrostatic self-assembly.
abstract: A new application of layer-by-layer assembly is presented, able to create nano/micro fibrils or nanocoatings inside 3D scaffolds using non-fibrillar polyelectrolytes for tissue-engineering applications. This approach shows promise for developing advanced scaffolds with controlled nano/micro environments, and nature and architectures similar to the natural extracellular matrix, leading to improved biological performance.
authors.affiliation: 3Bs Research Group-Biomaterials, Biodegradables and Biomimetics, AvePark, Zona Industrial da Gandra S. Claúdio do Barco, 4806-909 Caldas das Taipas - Guimarães, Portugal.
authors.forename: Sara M
authors.initials: SM
authors.lastname: Oliveira
authors.forename: Tiago H
authors.initials: TH
authors.lastname: Silva
authors.forename: Rui L
authors.initials: RL
authors.lastname: Reis
authors.forename: João F
authors.initials: JF
authors.lastname: Mano
mesh_terms: D000464:Alginates / Q000737:chemistry; D000469:Alkaline Phosphatase / Q000378:metabolism; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry; D004247:DNA / Q000378:metabolism; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology; D010006:Osteoblasts; D055672:Static Electricity; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds / Q000737:chemistry*; D055114:X-Ray Microtomography
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D046912:Multiprotein Complexes; D020723:Glucuronic Acid; D004247:DNA; D048271:Chitosan; D000469:Alkaline Phosphatase