title: Risk score for the prediction of contrast-induced nephropathy in elderly patients undergoing percutaneous coronary intervention.
abstract: We developed a risk score for contrast-induced nephropathy (CIN) in elderly patients (n = 668) before percutaneous coronary intervention (PCI). Another 277 elderly patients were studied for validation. Based on the odds ratio, risk factors were assigned a weighted integer; the sum of the integers was the risk score. Among the 668 elderly patients, 105 (15.7%) experienced CIN. There were 9 risk factors for CIN (with weighted integer): estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) (4), diabetes (3), left ventricular ejection fraction <45% (3), hypotension (2), age >70 years (2), myocardial infarction (2), emergency PCI (2), anemia (2), and contrast agent volume >200 mL (2). The incidence of CIN was 3.4%, 11.9%, 36.9%, and 69.8% in the low-risk (≤4), moderate risk (5-8), high-risk (9-12), and very-high-risk groups (≥13). The model demonstrated good discriminative power in the validation population (c statistic = 0.79). This score can be used to plan preventative measures.
authors.affiliation: Department of Cardiology, Tianjin Chest Hospital, Tianjin Medical University, Tianjin, China.
authors.forename: Naikuan
authors.initials: N
authors.lastname: Fu
authors.forename: Ximing
authors.initials: X
authors.lastname: Li
authors.forename: Shicheng
authors.initials: S
authors.lastname: Yang
authors.forename: Yongli
authors.initials: Y
authors.lastname: Chen
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
authors.forename: Dongxia
authors.initials: D
authors.lastname: Jin
authors.forename: Hongliang
authors.initials: H
authors.lastname: Cong
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000453:epidemiology*; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013318:Stroke Volume
chemical_list: D003287:Contrast Media