title: Ultrasound-mediated targeted drug delivery: recent success and remaining challenges.
abstract: The potential clinical value of developing a novel, nonviral, ultrasound-directed gene and drug delivery system is immense. Investigators soon will initiate clinical trials with the goal of treating a wide variety of maladies using noninvasive, ultrasound-based technology. The ongoing, scientific validation associated with promising preclinical success portents a novel range of therapeutics. The clinical utility and eventual clinical successes await vigorous testing. This review highlights the recent successes and challenges within the field of ultrasound-mediated drug delivery.
authors.affiliation: General Electric Global Research, Niskayuna, New York, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Castle
authors.forename: Matthew
authors.initials: M
authors.lastname: Butts
authors.forename: Andrew
authors.initials: A
authors.lastname: Healey
authors.forename: Kevin
authors.initials: K
authors.lastname: Kent
authors.forename: Michael
authors.initials: M
authors.lastname: Marino
authors.forename: Steven B
authors.initials: SB
authors.lastname: Feinstein
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D003287:Contrast Media; D016503:Drug Delivery Systems / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D045423:Microbubbles; D012076:Renal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D018084:Ultrasonography, Interventional; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D012076:Renal Agents