title: The SILVA ribosomal RNA gene database project: improved data processing and web-based tools.
abstract: SILVA (from Latin silva, forest, http://www.arb-silva.de) is a comprehensive web resource for up to date, quality-controlled databases of aligned ribosomal RNA (rRNA) gene sequences from the Bacteria, Archaea and Eukaryota domains and supplementary online services. The referred database release 111 (July 2012) contains 3 194 778 small subunit and 288 717 large subunit rRNA gene sequences. Since the initial description of the project, substantial new features have been introduced, including advanced quality control procedures, an improved rRNA gene aligner, online tools for probe and primer evaluation and optimized browsing, searching and downloading on the website. Furthermore, the extensively curated SILVA taxonomy and the new non-redundant SILVA datasets provide an ideal reference for high-throughput classification of data from next-generation sequencing approaches.
authors.affiliation: Microbial Genomics and Bioinformatics Research Group, Max Planck Institute for Marine Microbiology, D-28359 Bremen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Quast
authors.forename: Elmar
authors.initials: E
authors.lastname: Pruesse
authors.forename: Pelin
authors.initials: P
authors.lastname: Yilmaz
authors.forename: Jan
authors.initials: J
authors.lastname: Gerken
authors.forename: Timmy
authors.initials: T
authors.lastname: Schweer
authors.forename: Pablo
authors.initials: P
authors.lastname: Yarza
authors.forename: Jörg
authors.initials: J
authors.lastname: Peplies
authors.forename: Frank Oliver
authors.initials: FO
authors.lastname: Glöckner
mesh_terms: D001105:Archaea / Q000145:classification / Q000235:genetics; D001419:Bacteria / Q000145:classification / Q000235:genetics; D030561:Databases, Nucleic Acid; D056890:Eukaryota / Q000235:genetics; D020459:Genes, rRNA; D059014:High-Throughput Nucleotide Sequencing; D020407:Internet; D012984:Software