title: Benzofuran and indole synthesis via Cu(I)-catalyzed coupling of N-tosylhydrazone and o-hydroxy or o-amino phenylacetylene.
abstract: A general and practical method to synthesize 2-substituted benzofurans and indoles is described. This method employs easily accessible N-tosylhydrazones and o-hydroxy or o-amino phenylacetylenes as substrates. The reaction proceeds through a CuBr-catalyzed coupling-allenylation-cyclization sequence under ligand-free conditions.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
authors.forename: Tiebo
authors.initials: T
authors.lastname: Xiao
authors.forename: Xichang
authors.initials: X
authors.lastname: Dong
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001572:Benzofurans; D006835:Hydrazones; D007211:Indoles; C044736:phenylacetylene; D003300:Copper; C030374:indole; C105430:benzofuran; D000114:Acetylene