title: [No evidence of malicious effect of NSAID treatment on bone healing].
abstract: The use of NSAIDs for postoperative pain management following orthopaedic surgery or during conservative treatment of fractures is controversial. Experimental animal models suggest NSAIDs inhibit bone healing. In a review of the literature, there was no clinical evidence to support categorical discard of NSAID for postoperative pain relief in uncomplicated cases. However, NSAID should be considered a potentiel risk factor of impaired bone healing and avoided in patients with a high risk of pseudoarthrosis. Recommended daily doses should be respected and duration of treatment should be limited.
authors.affiliation: Anæstesiologisk Afdeling, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 København NV, Denmark. susannejanum@gmail.com
authors.forename: Susanne
authors.initials: S
authors.lastname: Janum
authors.forename: Billy Bjarne
authors.initials: BB
authors.lastname: Kristensen
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002146:Bony Callus / Q000187:drug effects*; D019317:Evidence-Based Medicine; D017102:Fracture Healing / Q000187:drug effects*; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal