title: The preparation of PLLA/calcium phosphate hybrid composite and its evaluation of biocompatibility.
abstract: In tissue engineering, biodegradable polymer materials with both high biocompatibility and high strength are very important as scaffolds for long term use. Therefore, in this research, we tried to prepare the three types of poly(L-lactic acid) (PLLA)/calcium phosphate (CP) hybrid composite for a scaffold biomaterial. The effects of addition of different CP on both biocompatibility and mechanical properties were evaluated. CP powders and voids were three-dimensionally and uniformly distributed in the solid samples and porous composite samples. These compositions of CP and PLLA greatly improved the cellular adhesiveness, which increased as the volume fraction of CP in the composite increased. For the porous samples, cells migrated into the pores. This study demonstrated that a composite of PLLA and CP is an effective new scaffold material that results in better osteoconductivity, bone regeneration, and mineralization and has moderately high strength.
authors.affiliation: Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science, Osaka 565-0871, Japan. y-hamada@sahs.med.osaka-u.ac.jp
authors.forename: Yoshinosuke
authors.initials: Y
authors.lastname: Hamada
authors.forename: Wataru
authors.initials: W
authors.lastname: Fujitani
authors.forename: Naomasa
authors.initials: N
authors.lastname: Kawaguchi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Daito
authors.forename: Tsutsu
authors.initials: T
authors.lastname: Niido
authors.forename: Ayako
authors.initials: A
authors.lastname: Uchinaka
authors.forename: Seiji
authors.initials: S
authors.lastname: Mori
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kojima
authors.forename: Masashi
authors.initials: M
authors.lastname: Manabe
authors.forename: Kiheiji
authors.initials: K
authors.lastname: Nishida
authors.forename: Kenji
authors.initials: K
authors.lastname: Arita
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Nakano
authors.forename: Nariaki
authors.initials: N
authors.lastname: Matsuura
mesh_terms: D016475:3T3 Cells; D020341:Absorbable Implants; D000818:Animals; D057005:Bioengineering; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004338:Drug Combinations; D019344:Lactic Acid / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D008422:Materials Testing; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects*; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis / Q000494:pharmacology; D016062:Porosity; D051381:Rats; D017207:Rats, Sprague-Dawley; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D002130:Calcium Phosphates; D004338:Drug Combinations; D011091:Polyesters; D011108:Polymers; C022045:octacalcium phosphate; D019344:Lactic Acid; C033616:poly(lactide)