title: Chaetoconvosins A and B, alkaloids with new skeleton from fungus Chaetomium convolutum.
abstract: Chaetoconvosins A and B (1 and 2), two novel cytochalasan alkaloids with a new 6/6/5/5/7 pentacyclic ring system, were isolated from the solid-state fermented medium of the wheat rhizospheric fungus Chaetomium convolutum cib-100. Their structures were elucidated on the basis of spectroscopic data. The structure of chaetoconvosin A (1) was confirmed by X-ray crystallographic analysis. Chaetoconvosin B (2), the major metabolite, showed remarkable inhibitory ability on root elongation and moderate cytotoxicity against several cancer cell lines.
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P. R. China.
authors.forename: Guo-Bo
authors.initials: GB
authors.lastname: Xu
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Guo-Lin
authors.initials: GL
authors.lastname: Zhang
authors.forename: Guo-You
authors.initials: GY
authors.lastname: Li
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002597:Chaetomium / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; C578413:chaetoconvosin A; C578414:chaetoconvosin B