title: [Treatment of chronic migraine and medication overuse headache].
abstract: Evidence has accumulated recently indicating biochemical, physiologic, pathophysiological alterations in the brain of patients with chronic migraine. Another type of the refractory headache for treatment is medication overuse headache. Both headaches are severely disabling and difficult to manage, as affected patients experience substantially more-frequent headaches, comorbid pain and affective disorders, and fewer pain-free intervals, than do those with episodic migraine. One principle for treatment is to stop medication of acute treatment (triptans, NSAIDs etc). Then preventive treatment must be started.
authors.affiliation: Kitasato University School of Medicine, Department of Neurology Kitasato Institute Hospital.
authors.forename: Junichi
authors.initials: J
authors.lastname: Hamada
mesh_terms: D000700:Analgesics / Q000009:adverse effects; D002908:Chronic Disease; D006801:Humans; D008881:Migraine Disorders / Q000139:chemically induced / Q000628:therapy*
chemical_list: D000700:Analgesics