title: Understanding the molecular sensitization for Cypress pollen and peach in the Languedoc-Roussillon area.
abstract: BACKGROUND
  Cypress allergy is a typical winter pollinosis and the most frequent one in the South of France. Main symptoms are rhinitis, conjunctivitis, and asthma. Peach allergy is common too in Southern Europe. Allergic cross-reactions between cypress and peach have been reported, including an oral allergy syndrome. We wanted to investigate whether a cross-reactive allergen between cypress and peach might be responsible for the observed clinical association.
  
  
  METHODS
  We analyzed 127 patients included over a 3-month period, outside the pollen season, and we dosed specific IgE levels, for selected, individual allergens.
  
  
  RESULTS
  Patients sensitized to peach were mainly positive for the peach-nonspecific lipid-transfer protein.
  
  
  CONCLUSIONS
  Profilins or thaumatins could not explain the observed clinical association between cypress and peach.
authors.affiliation: Département de Pneumologie, University Hospital of Montpellier, Hôpital Arnaud de Villeneuve and INSERM U657 - EA2415, Montpellier, France.
authors.forename: D
authors.initials: D
authors.lastname: Caimmi
authors.forename: D
authors.initials: D
authors.lastname: Barber
authors.forename: K
authors.initials: K
authors.lastname: Hoffmann-Sommergruber
authors.forename: H
authors.initials: H
authors.lastname: Amrane
authors.forename: P-J
authors.initials: PJ
authors.lastname: Bousquet
authors.forename: H
authors.initials: H
authors.lastname: Dhivert-Donnadieu
authors.forename: P
authors.initials: P
authors.lastname: Demoly
mesh_terms: D000328:Adult; D000485:Allergens; D052179:Antigens, Plant / Q000276:immunology; D001249:Asthma / Q000175:diagnosis / Q000276:immunology; D015331:Cohort Studies; D003429:Cross Reactions / Q000276:immunology*; D029781:Cupressus / Q000276:immunology*; D005260:Female; D005602:France; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000503:physiopathology; D007114:Immunization / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011058:Pollen / Q000276:immunology; D011446:Prospective Studies; D027861:Prunus / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000276:immunology; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012882:Skin Tests / Q000379:methods
chemical_list: D000485:Allergens; D052179:Antigens, Plant