title: DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters.
abstract: This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or candidates for drug development. Biosynthesis of each secondary metabolite is catalyzed by a number of enzymes, usually encoded by a gene cluster. Although many scientific papers describe such gene clusters, the gene information is not always described in a comprehensive manner and the related information is rarely integrated. DoBISCUIT integrates the latest literature information and provides standardized gene/module/domain descriptions related to the gene clusters.
authors.affiliation: Biological Resource Center, National Institute of Technology and Evaluation (NBRC), 2-49-10 Nishihara, Shibuya-ku, Tokyo 151-0006, Japan.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Ichikawa
authors.forename: Machi
authors.initials: M
authors.lastname: Sasagawa
authors.forename: Mika
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Komaki
authors.forename: Yumi
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Shuji
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Fujita
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D030541:Databases, Genetic; D005798:Genes, Bacterial; D020407:Internet; D005810:Multigene Family; D010453:Peptide Synthases / Q000235:genetics; D048630:Polyketide Synthases / Q000235:genetics; D014584:User-Computer Interface
chemical_list: D048630:Polyketide Synthases; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase