title: Cyclopentadiene-phosphine/palladium-catalyzed cleavage of C-N bonds in secondary amines: synthesis of pyrrole and indole derivatives from secondary amines and alkenyl or aryl dibromides.
abstract: An efficient Pd-catalyzed cleavage of C(sp(3))-N bonds in secondary amines and a consequent C(sp(2))-N and C(sp(3))-N coupling process was developed. Various secondary amines could be used to react with alkenyl or aryl dibromides, affording pyrroles and indoles in high yields. Cyclopentadiene-phosphine ligands, a new type of P-olefin ligand, were found to be able to promote the efficiency of this Pd-catalyzed process remarkably. A reactive Pd complex coordinated with a cyclopentadiene-phosphine ligand was successfully isolated and structurally characterized.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry, Peking University, Beijing 100871, China.
authors.forename: Weizhi
authors.initials: W
authors.lastname: Geng
authors.forename: Wen-Xiong
authors.initials: WX
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Hao
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Xi