title: High-density lipoproteins and myocardial necrosis in patients with acute myocardial infarction and ST segment elevation.
abstract: OBJECTIVE
  Low plasma levels of high-density lipoprotein cholesterol (HDLC) is a prognostic factor in patients with acute coronary syndrome. The aim of this study was to evaluate the relationship between HDLC and myocardial necrosis estimated by cardiac magnetic resonance (CMR) in patients with acute ST-segment elevation myocardial infarction (STEMI) and reperfusion strategy.
  
  
  METHODS
  Retrospective analysis of 139 patients (mean age 59.8 years; 79% men) admitted with STEMI who underwent a CMR in the first week.
  
  
  RESULTS
  With a comparable reperfusion strategy used and time of ischemia, patients with HDLC ≤40 mg/dl (69% of total) had more extensive areas of myocardial necrosis after STEMI, in number of segments with late gadolinium enhancement (RTG) with transmural necrosis pattern (4.7 vs. 2.1%, p < .001) and in percentage of RTG with respect to total mass myocardial (18.2 vs. 11.3%, p < .01), and worst left ventricular ejection fraction (LVEF) (49.7 vs. 57.2%, p < .001).
  
  
  CONCLUSIONS
  We conclude that low HDLC are very common in patients with STEMI and associated with increased necrosis and a worse LVEF in the CRM study.
authors.affiliation: Servicio de Cardiología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain. osfan@comv.es
authors.forename: Ó
authors.initials: Ó
authors.lastname: Fabregat-Andrés
authors.forename: M
authors.initials: M
authors.lastname: Ferrando-Beltrán
authors.forename: E
authors.initials: E
authors.lastname: Lucas-Inarejos
authors.forename: J
authors.initials: J
authors.lastname: Estornell-Erill
authors.forename: L
authors.initials: L
authors.lastname: Fácila
authors.forename: F
authors.initials: F
authors.lastname: Ridocci-Soriano
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL