title: Substituted imidazo[1,2-a]pyridines as β-strand peptidomimetics.
abstract: New conformationally extended dipeptide surrogates based on an imidazo[1,2-a]pyridine scaffold are described. Efficient synthesis and incorporation into host peptides affords structures with native side-chain functionality and hydrogen bonding elements on one face of the backbone. Structural analysis by NMR suggests that model peptidomimetics adopt a β-strand-like conformation in solution.
authors.affiliation: Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, United States.
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Kang
authors.forename: Yongmao
authors.initials: Y
authors.lastname: Sun
authors.forename: Juan R
authors.initials: JR
authors.lastname: Del Valle
mesh_terms: D007093:Imidazoles / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000737:chemistry; D017433:Protein Structure, Secondary; D011725:Pyridines / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D010455:Peptides; D057786:Peptidomimetics; D011725:Pyridines