title: Building a centriole.
abstract: Centrioles are the key foundation of centrosomes and cilia, yet a molecular understanding of how they form has only recently begun to emerge. Building a fully functional centriole that can form a centrosome and cilium requires two cell cycles. Centriole building starts with procentriole nucleation, a process that is coordinated by the conserved proteins Plk4/Zyg-1, and Asterless/Cep152. Subsequently, Sas-6, a conserved procentriole protein, self-assembles to provide nine-fold symmetry to the centriole scaffold. The procentriole then continues to elongate into a centriole, a process controlled by Sas-4/CPAP and CP110. Then, centrioles recruit Sas-4-mediated pre-assembled centrosomal complexes from the cytoplasm to form the pericentriolar material (PCM). Finally, CP110 and its interacting proteins are involved in controlling the timing of centriole templating of the cilium.
authors.affiliation: Department of Biological Sciences, University of Toledo, Toledo, OH 43606, USA. Tomer.AvidorReiss@utoledo.edu
authors.forename: Tomer
authors.initials: T
authors.lastname: Avidor-Reiss
authors.forename: Jayachandran
authors.initials: J
authors.lastname: Gopalakrishnan
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002502:Centrioles / Q000737:chemistry / Q000378:metabolism*; D002923:Cilia / Q000378:metabolism; D006801:Humans