title: A 20-year retrospective study of oral and maxillofacial histopathology in a South African paediatric population sample.
abstract: BACKGROUND
  The characterisation of oral and maxillofacial (OMF) histopathology found in children has not yet been reported from South Africa.
  
  
  OBJECTIVE
  This study aims to evaluate the spectrum of OMF histopathological diagnoses encountered in a sample of South African children.
  
  
  METHODS
  A retrospective study was designed to analyse the clinico-pathologic data, as obtained from OMF histopathology reports, at the University of the Witwatersrand's Division of Oral Pathology over a 20-year period.
  
  
  CONCLUSIONS
  A total of 1,258 OMF biopsies from children < or = 16 years of age with histologically confirmed disease were recorded, accounting for 6,5% of the total number of OMF biopsies received during this period. Pathology involving the jaw bones formed the largest category of all OMF pathologies and was predominated by odontogenic cysts and tumours. The remaining pathology, in decreasing order of frequency; involved the oral/perioral soft tissues, salivary glands and oral mucosa. Malignant neoplasms comprised 4,1% of the total number of cases with Burkitt's lymphoma emerging as the most common malignancy. Although the smallest number of biopsy specimens was obtained from children younger than 5-years of age, the likelihood of a malignant diagnosis in this age group was substantially higher than in older children.
authors.affiliation: Division of Oral and Maxillofacial Surgery, Faculty of Health Sciences, University of the Witwatersrand. dr.cmunsamy@yahoo.com
authors.forename: C
authors.initials: C
authors.lastname: Munsamy
authors.forename: F
authors.initials: F
authors.lastname: Mahomed
authors.forename: E
authors.initials: E
authors.lastname: Rikhotso
mesh_terms: D000293:Adolescent; D001706:Biopsy / Q000706:statistics & numerical data; D002051:Burkitt Lymphoma / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005882:Gingival Diseases / Q000453:epidemiology; D005887:Gingival Neoplasms / Q000453:epidemiology; D006801:Humans; D007571:Jaw Diseases / Q000453:epidemiology*; D007573:Jaw Neoplasms / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D009059:Mouth Diseases / Q000453:epidemiology*; D009062:Mouth Neoplasms / Q000453:epidemiology; D009807:Odontogenic Cysts / Q000453:epidemiology; D009808:Odontogenic Tumors / Q000453:epidemiology; D012189:Retrospective Studies; D012466:Salivary Gland Diseases / Q000453:epidemiology; D013019:South Africa / Q000453:epidemiology