title: Cost-minimization analysis of fingolimod compared with natalizumab for the treatment of relapsing-remitting multiple sclerosis in Sweden.
abstract: BACKGROUND
  Fingolimod and natalizumab have the same European Union licence for the treatment of relapsing multiple sclerosis, and are considered by the Committee for Medicinal Products for Human Use (CHMP) to have broadly similar efficacy.
  
  
  OBJECTIVE
  A cost-minimization analysis was performed to compare differences in treatment costs between fingolimod and natalizumab from a societal perspective in Sweden.
  
  
  METHODS
  This analysis included costs associated with initiating and following treatment (physician visits and monitoring), continuing therapy (drugs and administration), and lost patient productivity and leisure time. Unit costs (in Swedish krona [SEK]) were based on regional data (median prices for physician visits and monitoring sessions). Natalizumab infusion costs were obtained from the national cost-per-patient database. Drug costs for both therapies were 15,651 SEK/28 days.
  
  
  RESULTS
  After 3 years, fingolimod use was associated with savings of 124,823 SEK/patient compared with natalizumab (total cost/patient: 566,718 SEK vs 691,542 SEK). Cost savings with fingolimod were 40,402 SEK/patient after 1 year and 301,730 SEK/patient after 10 years. Treatment with natalizumab was 18% more expensive than fingolimod therapy after 1 year and 23% more expensive after 10 years.
  
  
  CONCLUSIONS
  Based on the CHMP assessment, it was assumed that fingolimod and natalizumab have similar efficacy. The analysis was conducted for Sweden, and caution is needed in extrapolating the results to other countries.
  
  
  CONCLUSIONS
  Fingolimod is cost-saving compared with natalizumab for the treatment of relapsing-remitting multiple sclerosis in Sweden.
authors.affiliation: Novartis Pharma AG, Basel, Switzerland. niklas.bergvall@novartis.com
authors.forename: Niklas
authors.initials: N
authors.lastname: Bergvall
authors.forename: Magnus
authors.initials: M
authors.lastname: Tambour
authors.forename: Freddie
authors.initials: F
authors.lastname: Henriksson
authors.forename: Sten
authors.initials: S
authors.lastname: Fredrikson
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000191:economics* / Q000627:therapeutic use; D017281:Cost of Illness; D003365:Costs and Cost Analysis / Q000379:methods; D000068876:Fingolimod Hydrochloride; D006801:Humans; D007166:Immunosuppressive Agents / Q000191:economics* / Q000627:therapeutic use; D055118:Medication Adherence; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000401:mortality; D000069442:Natalizumab; D011409:Propylene Glycols / Q000191:economics* / Q000627:therapeutic use; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use; D013548:Sweden / Q000453:epidemiology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D007166:Immunosuppressive Agents; D000069442:Natalizumab; D011409:Propylene Glycols; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine