title: MyomiRs-133a/b turn off the heat.
abstract: Brown adipose tissue is intensively researched owing to its role in regulating energy and glucose homeostasis. Its differentiation is controlled through adrenergic-dependent regulation of the transcriptional co-regulator Prdm16. Adrenergic stimulation inhibits expression of miR-133a/b in a Mef2c-dependent manner to abrogate post-transcriptional silencing of Prdm16.
authors.affiliation: Max Planck Institute for Neurological Research, Gleueler Street 50a, 50931 Köln, Germany.
authors.forename: Jan-Wilhelm
authors.initials: JW
authors.lastname: Kornfeld
authors.forename: Jens C
authors.initials: JC
authors.lastname: Brüning
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D002001:Adipose Tissue, Brown / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000378:metabolism*; D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D035683:MicroRNAs; C517732:Mirn133 microRNA, mouse; C521133:Prdm16 protein, mouse; D014157:Transcription Factors