title: Dual-specificity phosphatases 2: surprising positive effect at the molecular level and a potential biomarker of diseases.
abstract: Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target.
authors.affiliation: Institute of Endemic Fluorosis Disease, Center for Endemic Disease Control, Center for Disease Control and Prevention, Harbin Medical University, Harbin, PRC.
authors.forename: W
authors.initials: W
authors.lastname: Wei
authors.forename: Y
authors.initials: Y
authors.lastname: Jiao
authors.forename: A
authors.initials: A
authors.lastname: Postlethwaite
authors.forename: J M
authors.initials: JM
authors.lastname: Stuart
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: D
authors.initials: D
authors.lastname: Sun
authors.forename: W
authors.initials: W
authors.lastname: Gu
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015415:Biomarkers; D054641:Dual Specificity Phosphatase 2 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007239:Infections / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D007249:Inflammation / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D020935:MAP Kinase Signaling System; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism
chemical_list: D015415:Biomarkers; D054641:Dual Specificity Phosphatase 2