title: Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin.
abstract: Fast-dissolving drug delivery systems were prepared by electrospinning using polyvinyl alcohol (PVA) as the filament-forming polymer and drug carrier. Caffeine and riboflavin were used as the model drugs. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and X-ray diffraction were applied to investigate the physicochemical properties of electrospun nanofibers. The SEM images showed that nanofibers prepared from electrospinning PVA/drug aqueous solutions possessed an ultrafine morphology with an average diameter in the range of 260-370 nm. Pharmacotechnical tests showed that PVA/caffeine and PVA/riboflavin nanofibrous mats had almost the same dissolution time (about 1.5 s) and wetting time (about 4.5 s). The release measurements indicated that drugs can be released in a burst manner (caffeine to an extent of 100% and riboflavin to an extent of 40% within 60 s) from the PVA nanofibrous matrices.
authors.affiliation: Technical University of Denmark, DTU Food, Søltofts Plads, B227, 2800 Kgs. Lyngby, Denmark.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Li
authors.forename: Muzafar A
authors.initials: MA
authors.lastname: Kanjwal
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Chronakis
mesh_terms: D000284:Administration, Oral; D002110:Caffeine / Q000008:administration & dosage* / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012256:Riboflavin / Q000008:administration & dosage* / Q000494:pharmacology*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D002110:Caffeine; D011142:Polyvinyl Alcohol; D012256:Riboflavin