title: [Mechanisms of cerebral damage in patients with HIV-infection].
abstract: Mechanisms of HIV transportation through blood-brain barrier, vascular plexus and interaction with cerebral cells having CD-4-receptors, CCR-5- and CXCR-4-coreceptors were studied. Cerebral damage developed through latent and acute periods also known as HIV-encephalopathy, HIV-associated neurocognitive dysfunction etc. Cerebral lesions are caused by a variety of chemical agents from pro-inflammatory cytokines to toxic HIV-proteins resulting in development of HIV-dementia through several years. Even early stage of this process revealed significant disturbances of glucose metabolism and evoked potentials EEG alterations which can serve as a marker of HIV-infection. Genetic differences of HIV in blood and spinal liquor with different drug resistance were revealed implying a new approach to therapy development.
authors.forename: N A
authors.initials: NA
authors.lastname: Beliakov
authors.forename: S V
authors.initials: SV
authors.lastname: Medvedev
authors.forename: T N
authors.initials: TN
authors.lastname: Trofimova
authors.forename: V V
authors.initials: VV
authors.lastname: Rassokhin
authors.forename: N E
authors.initials: NE
authors.lastname: Dement'eva
authors.forename: S A
authors.initials: SA
authors.lastname: Shelomov
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000821:virology; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000378:metabolism / Q000503:physiopathology / Q000821:virology; D002490:Central Nervous System / Q000378:metabolism / Q000503:physiopathology / Q000821:virology; D024882:Drug Resistance, Viral / Q000235:genetics; D006678:HIV / Q000235:genetics / Q000502:physiology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D011379:Prognosis; D019562:Viral Load / Q000187:drug effects; D018406:Virus Physiological Phenomena / Q000187:drug effects / Q000235:genetics
chemical_list: D019380:Anti-HIV Agents