title: Acylsulfonamide safety-catch linker: promise and limitations for solid-phase oligosaccharide synthesis.
abstract: Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the cleavage products revealed shortcomings for oligosaccharide synthesis.
authors.affiliation: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14776 Potsdam, Germany ; Freie Universität Berlin, Institut für Chemie und Biochemie, Arnimallee 22, 14195 Berlin, Germany.
authors.forename: Jian
authors.initials: J
authors.lastname: Yin
authors.forename: Steffen
authors.initials: S
authors.lastname: Eller
authors.forename: Mayeul
authors.initials: M
authors.lastname: Collot
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger