title: [Lung carcinoma in a patient with rheumatoid arthritis treated with tumor necrosis factor antagonist].
abstract: A 65-year-old male was referred to our department because of an abnormal shadow on chest X-ray. He had been suffering from rheumatoid arthritis for 10 years. He had been treated with tumor necrosis factor antagonist(etanercept)for the past 3 years and 6 months. Computed tomography of the chest revealed an irregular shaped pulmonary nodule with the longest diameter of 4.3 cm in the left upper lobe. The diagnosis of lung carcinoma was made. He underwent video-assisted left upper lobectomy with lymph node dissection. Histological examination revealed poorly differentiated squamous cell carcinoma. The tumor was classified as stage ⅢA with T4(pm2)N1M0. No adjuvant chemotherapy was performed because he had recurrent arthralgia after operation and new anti-rheumatic-drug was required. He is free from disease with a follow-up period of 11 months.
authors.affiliation: Department of Surgery, Sapporo Medical Center Tonan Hospital, Sapporo, Japan.
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Okubo
authors.forename: Masaya
authors.initials: M
authors.lastname: Kawada
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yo
authors.initials: Y
authors.lastname: Kawarada
authors.forename: Shuji
authors.initials: S
authors.lastname: Kitashiro
authors.forename: Shunichi
authors.initials: S
authors.lastname: Okushiba
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D000068800:Etanercept; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D018501:Antirheumatic Agents; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept