title: Hybrid BaYbF(5) nanoparticles: novel binary contrast agent for high-resolution in vivo X-ray computed tomography angiography.
abstract: A novel CT contrast agent denoted as BaYbF(5) @SiO(2) @PEG is presented. The as-prepared nanoparticles exhibit significantly enhanced contrast efficacy relative to clinical iodinated agents and maintain higher X-ray attenuation at different voltages, suitable for diagnostic imaging of various patients. Prolonged circulation time in vivo and low toxicity mean the nanoparticles perform excellently in in-vivo X-ray CT angiography.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
authors.forename: Yanlan
authors.initials: Y
authors.lastname: Liu
authors.forename: Kelong
authors.initials: K
authors.lastname: Ai
authors.forename: Jianhua
authors.initials: J
authors.lastname: Liu
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Yuan
authors.forename: Yangyang
authors.initials: Y
authors.lastname: He
authors.forename: Lehui
authors.initials: L
authors.lastname: Lu
mesh_terms: D000792:Angiography / Q000379:methods*; D000818:Animals; D017609:Barium Compounds / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis; D005459:Fluorides / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011817:Rabbits; D011856:Radiographic Image Enhancement / Q000379:methods*; D051381:Rats; D014057:Tomography, X-Ray Computed / Q000379:methods*; D015018:Ytterbium / Q000737:chemistry
chemical_list: D017609:Barium Compounds; D003287:Contrast Media; C102799:ytterbium fluoride; C055150:barium fluoride; D015018:Ytterbium; D005459:Fluorides