title: A new ursane-type nor-triterpenoid from the leaves of Eucommia ulmoides Oliv.
abstract: A new ursane-type nortriterpenoid, (11S,12S)-4-methyl-11,12-epoxy-2-hydroxy-3-oxoursa-1,4-dine-28-oic acid &#947;-lactone (1), named ulmoidol A, together with ten known compounds: ulmoidol (2), corosolic acid (3), 2&#945;,3&#945;-dihydroxy-24-nor-4(23),12-oleanadien-28-oic acid (4), oleanolic acid (5), ursolic acid (6), cycloart-3&#946;, 25-diol (7), foliasalacioside B1 (8), (6R,7E,9R)-9-hydroxy-4,7-megastigmadien-3-one-9-O-&#945;-L-arabinopyranosyl-(1&#8594;6)-&#946;-D-glucopyranoside (9), (6R,7E,9R)-9-hydroxy-4,7-megastigma-dien-3-one-9-O-&#946;-D-xylopyranosyl-(1&#8594;6)-&#946;-D-glucopyranoside (10), and quercetin 3-O-sambubioside (11) were isolated from the leaves of Eucommia ulmoides Oliv. The structure of compound 1 was determined by extensive spectroscopic analysis, and its absolute configuration was determined by CD experiments and a computational method. Compounds 3, 4, 7&#8211;10 were isolated from this plant for the first time. Compounds 3 and 4 showed inhibition to PTPIB activities, with IC(50) values of 0.69 and 3.98 &#956;M, respectively.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. lichuangjun@imm.ac.cn
authors.forename: Chuangjun
authors.initials: C
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Jingzhi
authors.initials: J
authors.lastname: Yang
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.forename: Jinying
authors.initials: J
authors.lastname: Tian
authors.forename: Yikang
authors.initials: Y
authors.lastname: Si
authors.forename: Dongming
authors.initials: D
authors.lastname: Zhang
mesh_terms: D031283:Eucommiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification; D053978:Pentacyclic Triterpenes
chemical_list: D010936:Plant Extracts; D014315:Triterpenes; C000606873:ursane; D053978:Pentacyclic Triterpenes