title: Pathogenesis of infantile hemangioma.
abstract: Cutaneous vascular anomalies are congenital disorders of abnormal vascular development and growth. Infantile hemangioma is a common type of vascular anomalies characterized by the abnormal growth of blood vessels in the early proliferative phase, followed by the gradual spontaneous regression of the lesion in the involuting phase. Over the past decade, significant advances have been made in our understanding of the cellular and molecular mechanisms that control the development, growth, and regression of infantile hemangioma. In this article, we present a comprehensive review of the current knowledge of the pathogenesis of hemangioma as well as promising research horizons and implications for new therapeutic advances.
authors.affiliation: Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA. tphung@bcm.edu
authors.forename: Thuy L
authors.initials: TL
authors.lastname: Phung
authors.forename: Marcelo
authors.initials: M
authors.lastname: Hochman
mesh_terms: D000818:Animals; D019070:Cell Lineage; D004195:Disease Models, Animal; D005145:Face / Q000098:blood supply*; D005153:Facial Neoplasms / Q000151:congenital / Q000209:etiology* / Q000473:pathology*; D006391:Hemangioma / Q000151:congenital / Q000209:etiology* / Q000473:pathology*; D006412:Hematopoietic Stem Cells; D006801:Humans; D007223:Infant; D059630:Mesenchymal Stem Cells; D051379:Mice; D009365:Neoplasm Regression, Spontaneous; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
chemical_list: D042461:Vascular Endothelial Growth Factor A