title: Experimental study of neuropharmacological profile of Euphorbia pulcherrima in mice and rats.
abstract: BACKGROUND
  Euphorbia pulcherrima (EP) belongs to the family: Euphorbiaceae and Genus: Euphorbia. Many species of Euphorbia have been reported as having beneficial properties like anticonvulsive effect, central analgesic properties, antipyretic action, central depressant action and strong sedative effect. However, little study has been done and published on EP.
  
  
  OBJECTIVE
  To observe and evaluate various neuropharmacological effects like antinociceptive effect, anticonvulsant effect, motor in-coordination, pentobarbital induced sleeping time and behavioral responses of EP in mice and rats.
  
  
  METHODS
  Quantitative experimental study in mice and rats by various experimental models.
  
  
  METHODS
  Different experimental models were used to assess the antinociceptive effect (hotplate, tail flick and acetic acid induced writhing test), anticonvulsant effect (Maximal Electroshock Seizure test [MES] and Pentylenetetrazole induced seizures [PTZ]), motor in-coordination effect (Rota rod test), pentobarbital induced sleeping time and behavioral responses of EP in mice and rats after oral administration of EP crude dried extracts in three different doses (250, 500 and 1000 mg/kg).
  
  
  METHODS
  The significance of difference with respect to control was evaluated using the Mann-Whitney U test. A probability (P-value) level less than 0.05 was considered as significant.
  
  
  RESULTS
  In MES test model, duration of tonic hind limb extension in mice treated with EP was significantly less as compared to vehicle treated group. EP was most effective in a dose of 1000 mg/kg. There was also significant increase in the latency and decrease in the incidence of convulsions with the use of EP in three different doses in PTZ induced seizure model.
  
  
  CONCLUSIONS
  This study showed EP (crude dried) extracts to possess anticonvulsant properties but no effect on motor co-ordination and anxiety.
authors.affiliation: Department of Clinical Pharmacology and Therapeutics, B.P. Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal.
authors.forename: Kundan Kr
authors.initials: KK
authors.lastname: Singh
authors.forename: Gajendra P
authors.initials: GP
authors.lastname: Rauniar
authors.forename: Himal
authors.initials: H
authors.lastname: Sangraula