title: ⁹⁹mTc-N4amG: synthesis biodistribution and imaging in breast tumor-bearing rodents.
abstract: (99m)Tc-N4-guanine ((99m)Tc-N4amG) was synthesized and evaluated in this study. Cellular uptake and cellular fraction studies were performed to evaluate the cell penetrating ability. Biodistribution and planar imaging were conducted in breast tumor-bearing rats. Up to 17%ID uptake was observed in cellular uptake study with 40% of (99m)Tc-N4amG was accumulated in the nucleus. Biodistribution and scintigraphic imaging studies showed increased tumor/muscle count density ratios as a function of time. Our results demonstrate the feasibility of using (99m)Tc-N4amG in tumor specific imaging.
authors.affiliation: Division of Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. ning.tsao@mdanderson.org
authors.forename: Ning
authors.initials: N
authors.lastname: Tsao
authors.forename: Mithu
authors.initials: M
authors.lastname: Chanda
authors.forename: Dong-Fang
authors.initials: DF
authors.lastname: Yu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kurihara
authors.forename: Yin-Han
authors.initials: YH
authors.lastname: Zhang
authors.forename: Richard
authors.initials: R
authors.lastname: Mendez
authors.forename: David J
authors.initials: DJ
authors.lastname: Yang
mesh_terms: D000818:Animals; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
chemical_list: D015609:Organotechnetium Compounds