title: VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children.
abstract: BACKGROUND
  VNN1 gene expression levels and the G-137T polymorphism have been associated with high density lipoprotein cholesterol (HDL-C) levels in Mexican American adults. We aim to evaluate the contribution of VNN1 gene expression and the G-137T variant to HDL-C levels and other metabolic traits in Mexican prepubertal children.
  
  
  RESULTS
  VNN1 mRNA expression levels were quantified in peripheral blood leukocytes from 224 unrelated Mexican-Mestizo children aged 6-8 years (107 boys and 117 girls) and were genotyped for the G-137T variant (rs4897612). To account for population stratification, a panel of 10 ancestry informative markers was analyzed. After adjustment for admixture, the TT genotype was significantly associated with lower VNN1 mRNA expression levels (P = 2.9 × 10(-5)), decreased HDL-C levels (β = -6.19, P = 0.028) and with higher body mass index (BMI) z-score (β = 0.48, P = 0.024) in the total sample. In addition, VNN1 expression showed a positive correlation with HDL-C levels (r = 0.220; P = 0.017) and a negative correlation with BMI z-score (r = -0.225; P = 0.015) only in girls.
  
  
  CONCLUSIONS
  Our data suggest that VNN1 gene expression and the G-137T variant are associated with HDL-C levels in Mexican children, particularly in prepubertal girls.
authors.affiliation: Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), Mexico City, Mexico.
authors.forename: Leonor
authors.initials: L
authors.lastname: Jacobo-Albavera
authors.forename: Pablo I
authors.initials: PI
authors.lastname: Aguayo-de la Rosa
authors.forename: Teresa
authors.initials: T
authors.lastname: Villarreal-Molina
authors.forename: Hugo
authors.initials: H
authors.lastname: Villamil-Ramírez
authors.forename: Paola
authors.initials: P
authors.lastname: León-Mimila
authors.forename: Sandra
authors.initials: S
authors.lastname: Romero-Hidalgo
authors.forename: Blanca E
authors.initials: BE
authors.lastname: López-Contreras
authors.forename: Fausto
authors.initials: F
authors.lastname: Sánchez-Muñoz
authors.forename: Rafael
authors.initials: R
authors.lastname: Bojalil
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: González-Barrios
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Aguilar-Salinas
authors.forename: Samuel
authors.initials: S
authors.lastname: Canizales-Quinteros
mesh_terms: D000581:Amidohydrolases / Q000097:blood / Q000235:genetics; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood / Q000235:genetics; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico; D011110:Polymorphism, Genetic
chemical_list: D008076:Cholesterol, HDL; D058851:GPI-Linked Proteins; D000581:Amidohydrolases; C022314:pantetheinase