title: Thiol-inducible direct fluorescence monitoring of drug release.
abstract: A new bifunctional compound NCC, which undergoes thiol-mediated disulfide cleavage after cell entry, produces a red-shifted fluorescent emission in the cytosol and releases free active DNA alkylating agent CLB into the nucleus, and finally leads to DNA damage and cell death.
authors.affiliation: College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Hubei, Wuhan, 430072, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.forename: Changcheng
authors.initials: C
authors.lastname: Wang
authors.forename: Wenting
authors.initials: W
authors.lastname: Liu
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaocheng
authors.initials: X
authors.lastname: Weng
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry* / Q000494:pharmacology; D002699:Chlorambucil / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D004220:Disulfides / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D006367:HeLa Cells; D006801:Humans; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism; D057054:Molecular Imaging; D055620:Optical Phenomena; D013050:Spectrometry, Fluorescence; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D004220:Disulfides; D004337:Drug Carriers; D013438:Sulfhydryl Compounds; D002699:Chlorambucil; D004247:DNA