title: H2DB: a heritability database across multiple species by annotating trait-associated genomic loci.
abstract: H2DB (http://tga.nig.ac.jp/h2db/), an annotation database of genetic heritability estimates for humans and other species, has been developed as a knowledge database to connect trait-associated genomic loci. Heritability estimates have been investigated for individual species, particularly in human twin studies and plant/animal breeding studies. However, there appears to be no comprehensive heritability database for both humans and other species. Here, we introduce an annotation database for genetic heritabilities of various species that was annotated by manually curating online public resources in PUBMED abstracts and journal contents. The proposed heritability database contains attribute information for trait descriptions, experimental conditions, trait-associated genomic loci and broad- and narrow-sense heritability specifications. Annotated trait-associated genomic loci, for which most are single-nucleotide polymorphisms derived from genome-wide association studies, may be valuable resources for experimental scientists. In addition, we assigned phenotype ontologies to the annotated traits for the purposes of discussing heritability distributions based on phenotypic classifications.
authors.affiliation: Genome Informatics Laboratory, National Institute of Genetics, 1111 Yata, Mishima 411-8540, Japan.
authors.forename: Eli
authors.initials: E
authors.lastname: Kaminuma
authors.forename: Takatomo
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tanizawa
authors.forename: Naoko
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Nori
authors.initials: N
authors.lastname: Kurata
authors.forename: Tokurou
authors.initials: T
authors.lastname: Shimizu
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D030561:Databases, Nucleic Acid; D056426:Genetic Loci; D016678:Genome; D006801:Humans; D020407:Internet; D058977:Molecular Sequence Annotation; D010641:Phenotype; D019655:Quantitative Trait, Heritable