title: Mimicking the biological ligand-receptor principle for universal target gene delivery mediated by avidin-biotin interaction.
abstract: A facile and flexible targeting gene-delivery strategy is reported by mimicking the biological ligand-receptor principle based on avidin-biotin interaction. In vitro and in vivo investigations demonstrate that this strategy provides a simple, but universal alternative for potential target gene delivery as well as drug delivery.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qu
authors.forename: Shan
authors.initials: S
authors.lastname: Ren
authors.forename: Ying
authors.initials: Y
authors.lastname: Kuang
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Jiang
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001360:Avidin / Q000737:chemistry* / Q000378:metabolism*; D001710:Biotin / Q000737:chemistry* / Q000378:metabolism*; D019556:COS Cells; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D002470:Cell Survival; D002522:Chlorocebus aethiops; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004705:Endocytosis; D018014:Gene Transfer Techniques; D006367:HeLa Cells; D006614:Hindlimb / Q000503:physiopathology; D006801:Humans; D007511:Ischemia / Q000628:therapy; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology
chemical_list: D043925:Angiogenesis Inducing Agents; D042461:Vascular Endothelial Growth Factor A; D001360:Avidin; D001710:Biotin; D004247:DNA