title: Sclerostin antibody prevents particle-induced implant loosening by stimulating bone formation and inhibiting bone resorption in a rat model.
abstract: OBJECTIVE
  To assess the ability of sclerostin antibody therapy to blunt the negative effects of polyethylene particles on implant fixation and peri-implant bone structure in a rat implant fixation model.
  
  
  METHODS
  Thirty-six adult male rats received intramedullary titanium implants; 12 rats received vehicle injections only (control), and 24 rats received intraarticular injections of lipopolysaccharide-doped polyethylene particles. Twelve of the rats that received particles also received sclerostin antibody treatment. The 3 groups of rats were maintained for 12 weeks in a pathogen-free environment, at which time mechanical, micro-computed tomography, and dynamic and static histomorphometry end points were assessed.
  
  
  RESULTS
  Sclerostin antibody treatment completely blocked the negative effect of the lipopolysaccharide-doped polyethylene particles on implant fixation and peri-implant bone volume by increasing the bone formation rate and depressing bone resorption.
  
  
  CONCLUSIONS
  Anabolic agents targeting the Wnt signaling pathway are a promising new alternative for the prevention of periprosthetic osteolysis and aseptic loosening.
authors.affiliation: Rush University Medical Center, Chicago, IL 60612, USA.
authors.forename: Shuo
authors.initials: S
authors.lastname: Liu
authors.forename: Amarjit S
authors.initials: AS
authors.lastname: Virdi
authors.forename: Kotaro
authors.initials: K
authors.lastname: Sena
authors.forename: Dale R
authors.initials: DR
authors.lastname: Sumner
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D019485:Bone Morphogenetic Proteins / Q000276:immunology*; D001862:Bone Resorption / Q000503:physiopathology / Q000517:prevention & control*; D005269:Femur / Q000000981:diagnostic imaging / Q000502:physiology / Q000601:surgery; D005819:Genetic Markers / Q000276:immunology*; D008297:Male; D023421:Models, Animal; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D020959:Polyethylene / Q000009:adverse effects*; D019736:Prostheses and Implants; D011475:Prosthesis Failure / Q000209:etiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000502:physiology; D014025:Titanium; D014057:Tomography, X-Ray Computed; D051153:Wnt Proteins / Q000502:physiology
chemical_list: D000906:Antibodies; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; C486031:Sost protein, rat; D051153:Wnt Proteins; D020959:Polyethylene; D014025:Titanium