title: Immunoregulation of myelin-specific CD4+ T cell response by neural stem/progenitor cells: role of prostaglandin E2.
abstract: The abnormal proliferation and polarization of Th17/Th1 subsets are believed to contribute to the progression of multiple sclerosis. We demonstrated that neural stem cells (NSCs) could inhibit CD4(+)T cells from mice of experimental autoimmune encephalomyelitis to proliferate and polarize into Th17 but promote their apoptosis and to generate regulatory T cells in response to myelin antigen via releasing prostaglandin E2 by activated Th1-derived IFN-γ. The study indicated that NSCs play a negatively regulatory role in T cell responses and provided novel evidence for the therapeutic mechanisms underlying the usage of NSCs to treat autoimmune diseases of central nervous system.
authors.affiliation: Department of Neurology, Changhai Hospital, 168 Changhai Road, Shanghai 200433, PR China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Xiao
authors.forename: Shuxun
authors.initials: S
authors.lastname: Liu
authors.forename: Yiping
authors.initials: Y
authors.lastname: Hu
authors.forename: Jun
authors.initials: J
authors.lastname: Tian
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Gao
authors.forename: Shanshan
authors.initials: S
authors.lastname: Xie
authors.forename: Yangtai
authors.initials: Y
authors.lastname: Guan
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D002478:Cells, Cultured; D018920:Coculture Techniques; D015232:Dinoprostone / Q000502:physiology*; D053595:Embryonic Stem Cells / Q000276:immunology* / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009186:Myelin Sheath / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D058953:Neural Stem Cells / Q000276:immunology* / Q000378:metabolism; D011247:Pregnancy
chemical_list: D015232:Dinoprostone