title: An organic molecule modulated chemoselective cyclization of alkynyl nitriles tethered to 2-alkyl substituted chromones with multireactive sites.
abstract: A small organic molecule phenylacetonitrile promoted chemoselective cyclization of (chromen-3-yl)alkynylnitriles to generate a novel tetracyclic or tricyclic chromone scaffold has been discovered. Importantly, the phenylacetonitrile serves as an anion transfer reagent changing the normal reaction of the substrate.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 ZuChongZhi Road, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Huang
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Fuchun
authors.initials: F
authors.lastname: Xie
authors.forename: Youhong
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000097:Acetonitriles / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000097:Acetonitriles; D000480:Alkynes; D002867:Chromones; D006576:Heterocyclic Compounds, 4 or More Rings; D009570:Nitriles; C006725:benzyl cyanide