title: MicroRNAs in biliary diseases.
abstract: Cholangiopathies are a group of diseases primarily or secondarily affecting bile duct cells, and result in cholangiocyte proliferation, regression, and/or transformation. Their etiopathogenesis may be associated with a broad variety of causes of different nature, which includes genetic, neoplastic, immune-associated, infectious, vascular, and drug-induced alterations, or being idiopathic. miRNAs, small non-coding endogenous RNAs that post-transcriptionally regulate gene expression, have been associated with pathophysiological processes in different organs and cell types, and are postulated as potential targets for diagnosis and therapy. In the current manuscript, knowledge regarding the role of miRNAs in the development and/or progression of cholangiopathies has been reviewed and the most relevant findings in this promising field of hepatology have been highlighted.
authors.affiliation: Division of Hepatology and Gastroenterology, Biodonostia Research Institute, Donostia Universitary Hospital, 20014 San Sebastián, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Munoz-Garrido
authors.forename: Maite
authors.initials: M
authors.lastname: García-Fernández de Barrena
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hijona
authors.forename: Miguel
authors.initials: M
authors.lastname: Carracedo
authors.forename: José J G
authors.initials: JJ
authors.lastname: Marín
authors.forename: Luis
authors.initials: L
authors.lastname: Bujanda
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Banales
mesh_terms: D000818:Animals; D001660:Biliary Tract Diseases / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D018450:Disease Progression; D005786:Gene Expression Regulation; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D010641:Phenotype; D011379:Prognosis; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs