title: Norcembranoidal diterpenes from a Formosan soft coral Sinularia sp.
abstract: Two norcembranoidal diterpenes, 5-episinuleptolide acetate (1) and scabrolide D (2), were isolated from a Formosan octocoral identified as Sinularia sp. The structures of norcembranoids 1 and 2 were established by spectroscopic methods and by comparison of the spectral data with those of known analogues and 1 was proven to be a new natural product. Norcembranoid 1 was found to exhibit cytotoxicity toward a panel of tumor cells.
authors.affiliation: Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Wei-Hsuan
authors.initials: WH
authors.lastname: Yen
authors.forename: Li-Chung
authors.initials: LC
authors.lastname: Hu
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.forename: Wen-Hung
authors.initials: WH
authors.lastname: Twan
authors.forename: Show-Ying
authors.initials: SY
authors.lastname: Yang
authors.forename: Yung-Chi
authors.initials: YC
authors.lastname: Kuo
authors.forename: Ching-Feng
authors.initials: CF
authors.lastname: Weng
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Lee
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D013624:Taiwan
chemical_list: D004224:Diterpenes; C477929:norcembrenolide