title: Key molecular pathways affected by glaucoma pathology: is predictive diagnosis possible?
abstract: Prediction and prevention of glaucoma. Neurodegenerative eye disease glaucoma is the second leading cause of blindness with estimated 67 million patients worldwide. Molecular pathomechanisms of glaucoma demonstrate both a considerable overlap with and remarkable particularities compared to other neurodegenerative disorders e.g. Alzheimer's disease. Identification of pathology-specific biomarker-sets is essential to develop advanced diagnostic approaches and personalised patients' treatment. Subcellular imaging and expression patterns in blood as the reliable platform for early/predictive glaucoma diagnosis. Following key pathways are affected in glaucoma pathology: stress response, apoptosis and DNA-repair, adhesion, blood-brain-barrier-breakdown, tissue remodelling, transcription regulation, multidrug resistance and energy metabolism.
authors.affiliation: Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany  ; European Association for Predictive, Preventive & Personalised Medicine,  www.epmanet.eu.
authors.forename: Olga
authors.initials: O
authors.lastname: Golubnitschaja
authors.forename: Kristina
authors.initials: K
authors.lastname: Yeghiazaryan
authors.forename: Josef
authors.initials: J
authors.lastname: Flammer