title: A simulation study of the radiation-induced bystander effect: modeling with stochastically defined signal reemission.
abstract: The radiation-induced bystander effect (RIBE) has been experimentally observed for different types of radiation, cell types, and cell culture conditions. However, the behavior of signal transmission between unirradiated and irradiated cells is not well known. In this study, we have developed a new model for RIBE based on the diffusion of soluble factors in cell cultures using a Monte Carlo technique. The model involves the signal emission probability from bystander cells following Poisson statistics. Simulations with this model show that the spatial configuration of the bystander cells agrees well with that of corresponding experiments, where the optimal emission probability is estimated through a large number of simulation runs. It was suggested that the most likely probability falls within 0.63-0.92 for mean number of the emission signals ranging from 1.0 to 2.5.
authors.affiliation: Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Sasaki
authors.forename: Kosuke
authors.initials: K
authors.lastname: Wakui
authors.forename: Kaori
authors.initials: K
authors.lastname: Tsutsumi
authors.forename: Akio
authors.initials: A
authors.lastname: Itoh
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Date
mesh_terms: D000465:Algorithms; D000818:Animals; D024201:Bystander Effect; D002450:Cell Communication / Q000528:radiation effects*; D003198:Computer Simulation; D006224:Cricetinae; D003412:Cricetulus; D004058:Diffusion; D004307:Dose-Response Relationship, Radiation; D060733:Electromagnetic Radiation; D015233:Models, Statistical; D008962:Models, Theoretical; D009010:Monte Carlo Method; D016012:Poisson Distribution; D011336:Probability; D015398:Signal Transduction / Q000528:radiation effects*; D013269:Stochastic Processes