title: Cancer stem cells: the 'heartbeat' of gastric cancer.
abstract: Gastric cancer (GC) remains one of the most common cancers worldwide. Its prevalence is still on the rise in the developing countries due to the ageing population. The cancer stem cell (CSC) theory provides a new insight into the interpretation of tumor initiation, aggressive growth, recurrence, and metastasis of cancer, as well as the development of new strategies for cancer treatment. This review will focus on the progress of biomarkers and signaling pathways of CSCs, the complex crosstalk networks between the microenvironment and CSCs, and the development of therapeutic approaches against CSCs, predominantly focusing on GC.
authors.affiliation: Clinical Medicine Research Center, Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot 010050, Inner Mongolia, China.
authors.forename: Guihua
authors.initials: G
authors.lastname: Xu
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Ou Yang
authors.forename: Masakiyo
authors.initials: M
authors.lastname: Sasahara
authors.forename: Xiulan
authors.initials: X
authors.lastname: Su
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D015995:Prevalence; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor