title: Vitamin D and secreted Klotho: a long-awaited panacea for vascular calcification?
abstract: Chronic kidney disease (CKD) is characterized by accelerated vascular calcification, which may in part be caused by deficiency of the anti-aging factor Klotho. Lau et al. demonstrate that administration of active vitamin D and its analog decreases aortic calcification in association with increases in two potent calcification inhibitors--the secreted form of Klotho and vascular osteopontin. These data might provide a new perspective on the association of active vitamin D with improved survival in patients with CKD.
authors.affiliation: Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Komaba
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fukagawa
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects*; D001018:Aortic Diseases / Q000517:prevention & control*; D002117:Calcitriol / Q000494:pharmacology*; D004032:Diet; D004872:Ergocalciferols / Q000494:pharmacology*; D005260:Female; D005966:Glucuronidase / Q000378:metabolism*; D000090265:Klotho Proteins; D053495:Osteopontin / Q000378:metabolism*; D010710:Phosphates; D018167:Receptors, Calcitriol / Q000819:agonists*; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy*; D061205:Vascular Calcification / Q000517:prevention & control*
chemical_list: D004872:Ergocalciferols; D010710:Phosphates; D018167:Receptors, Calcitriol; C506896:Spp1 protein, mouse; D053495:Osteopontin; C084656:paricalcitol; D005966:Glucuronidase; D000090265:Klotho Proteins; D002117:Calcitriol