title: ATDC5: an excellent in vitro model cell line for skeletal development.
abstract: The ATDC5 cell line is derived from mouse teratocarcinoma cells and characterized as a chondrogenic cell line which goes through a sequential process analogy to chondrocyte differentiation. Thus, it is regarded as a promising in vitro model to study the factors that influence cell behaviors during chondrogenesis. It also provides insights in exploring signaling pathways related to skeletal development as well as interactions with innovative materials. To date, over 200 studies have utilized ATDC5 to obtain lots of significant findings. In this review, we summarized the literature of ATDC5 related studies and emphasized the application of ATDC5 in chondrogenesis. In addition, the general introduction of ATDC5 including its derivation and characterization is covered in this article.
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Yongchang
authors.initials: Y
authors.lastname: Yao
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D001846:Bone Development; D045744:Cell Line, Tumor; D020219:Chondrogenesis; D005069:Evaluation Studies as Topic; D018507:Gene Expression Regulation, Developmental; D006728:Hormones / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
chemical_list: D006728:Hormones; D036341:Intercellular Signaling Peptides and Proteins; D014157:Transcription Factors