title: Polycystic ovary syndrome offspring display increased oxidative stress markers comparable to gestational diabetes offspring.
abstract: OBJECTIVE
  To study oxidative stress (OS) markers on neonates. The specific aim was to evaluate advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) serum levels along with the hormonal/metabolic profile and their possible relationship in a cohort of polycystic ovary syndrome PCOS(N) and gestational diabetes GDM(N) neonates and their mothers PCOS(M) and GDM(M).
  
  
  METHODS
  Prospective controlled study.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  The study population comprised 151 mother/neonate pairs.
  
  
  METHODS
  Diet and/or insulin administration in GDM(M).
  
  
  METHODS
  Anthropometric, metabolic, hormonal parameters, and OS markers.
  
  
  RESULTS
  The AGEs and AOPPs were higher in PCOS(M) and GDM(M) compared with controls (M). The same significant difference was observed in the corresponding groups of neonates. A strong relationship between mothers and neonates regarding AGEs (r = 0.605) and AOPPs levels (r = 0.735) was disclosed. Analogous findings were observed regarding androgens and insulin resistance in mothers and neonates, respectively.
  
  
  CONCLUSIONS
  The present study demonstrated that in PCOS(N), the OS status was similar to that of GDM(N) and strongly associated with their mothers' oxidative status. These findings may have clinical implications, as exposure of PCOS(N) to high OS levels during pregnancy could affect several health issues of neonates.
authors.affiliation: Endocrine Unit, Third Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Boutzios
authors.forename: Sarantis
authors.initials: S
authors.lastname: Livadas
authors.forename: Christina
authors.initials: C
authors.lastname: Piperi
authors.forename: Nicolaos
authors.initials: N
authors.lastname: Vitoratos
authors.forename: Christos
authors.initials: C
authors.lastname: Adamopoulos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Hassiakos
authors.forename: Christos
authors.initials: C
authors.lastname: Iavazzo
authors.forename: Evanthia
authors.initials: E
authors.lastname: Diamanti-Kandarakis
mesh_terms: D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000378:metabolism; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D007231:Infant, Newborn; D015999:Multivariate Analysis; D018384:Oxidative Stress / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D011247:Pregnancy; D011446:Prospective Studies; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; C517652:hemoglobin A1c protein, human