title: Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold.
abstract: Dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives were prepared by successive N3- and N1-alkylation of hydantoins, followed by regioselective thionation and subsequent cyclization under mild conditions. In a final alkylation step a further substituent may be introduced. The synthetic strategy allows broad structural variation of this new drug-like heterobicyclic scaffold. In addition to extensive NMR and MS analyses, the structure of one derivative was confirmed by X-ray crystallography.
authors.affiliation: PharmaCenter Bonn, Pharmaceutical Sciences Bonn (PSB), University of Bonn, Pharmaceutical Institute, An der Immenburg 4, 53121 Bonn, Germany.
authors.forename: Nikolay T
authors.initials: NT
authors.lastname: Tzvetkov
authors.forename: Harald
authors.initials: H
authors.lastname: Euler
authors.forename: Christa E
authors.initials: CE
authors.lastname: Müller