title: Treatment with Suprelorin in a pregnant cat.
abstract: Suppression of oestrus is of major interest in feral cat populations, but also in breeding queens temporarily not intended for breeding. Slow release gonadotropin-releasing hormone (GnRH) agonist implants are a new off-label approach for reproduction control in cats. However, initially, oestrus induction may occur and no data exist regarding what happens if previously mated queens are treated. This case report presents a queen mismated 9 and 8 days before treatment with a 4.7 mg deslorelin implant. The queen delivered four healthy kittens 66 days after mismating, but showed no interest in the kittens and lactation was not adequate. Progesterone and oestradiol concentrations were monitored and the queen was followed until the return of oestrus and subsequent breeding. The next oestrus was observed 498 days after treatment and the queen was mated in the second oestrus afterwards, became pregnant and delivered two healthy kittens, both of which were raised successfully by the queen. This case report clearly shows that pregnancy following a GnRH-agonist implant may go to term, but maternal care might be influenced owing to hormonal changes induced by treatment. In addition, this is the first report demonstrating reversibility of effects induced by long-term treatment with a deslorelin implant (return to oestrus, fertility and normal maternal care).
authors.affiliation: Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig Universität Giessen, Frankfurter Strasse, Giessen, Germany. Sandra.Goericke-Pesch@vetmed.uni-giessen.de
authors.forename: Sandra
authors.initials: S
authors.lastname: Goericke-Pesch
authors.forename: Plamen
authors.initials: P
authors.lastname: Georgiev
authors.forename: Anatoli
authors.initials: A
authors.lastname: Atanasov
authors.forename: Axel
authors.initials: A
authors.lastname: Wehrend
mesh_terms: D000818:Animals; D002415:Cats / Q000502:physiology; D003267:Contraception / Q000379:methods / Q000662:veterinary*; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D004343:Drug Implants; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006080:Ovarian Follicle / Q000187:drug effects*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D003271:Contraceptive Agents, Female; D004343:Drug Implants; D004791:Enzyme Inhibitors; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; C066438:deslorelin