title: Relationship of self-reported exercise tolerance with inflammatory markers in women with stable ischemic heart disease.
abstract: OBJECTIVE
  Ischemic heart disease (IHD) is associated with decreased exercise tolerance and it is subjectively reported as angina pectoris or dyspnea. Inflammation and pro- inflammatory cytokines are related to progression of IHD, but their level is seldom analyzed in association with self reported exercise tolerance.
  
  
  METHODS
  Women aged 35-75 years with stable IHD from Homocysteine Slovakia study (N=175) were analyzed for monocyte chemoatractant protein-1 (MCP-1), interleukin 6 (IL-6), transforming growth factor β1 (TGF β1), Mannan binding lectin (MBL), heat shock proteins 60 (HSP60), carbonyl protein (CP), high sensitivity C-reactive protein (hsCRP) and oxidized glutathione (GSSG) in relation to exercise induced dyspnea or angina pectoris (AP) (≤200 m).
  
  
  RESULTS
  Patients with dyspnea had higher HSP60 (77.3±107.2 vs 43.7±48.9 ng/ml; p=0.014) and IL-6 (2.9±1.3 vs 1.9±0.6 pg/ml; p=0.04) levels. IL-6 and HSP60 demonstrated direct correlation with dyspnea (rho=0.39; p=0.02 resp. rho=0.22; p=0.01). AP≤200 m patients showed only decreased protein carbonyl a marker of protein oxidation and increased oxidative stress (CP 61.7±27.3 vs. 72.1±23.1 pg/ml; p=0.001). CP indirectly correlates with AP≤200 m (rho=-0.25; p=0.001).
  
  
  CONCLUSIONS
  We have found associations of pro-inflammatory cytokines and inflammation markers with dyspnea or angina pectoris, but the relationship was not consistent in our patients with stable ischemic heart disease.
authors.affiliation: 2nd Department of Internal Medicine, Comenius University, Bratislava, Slovakia. jan.lietava@yahoo.com
authors.forename: Jan
authors.initials: J
authors.lastname: Lietava
authors.forename: Branislav
authors.initials: B
authors.lastname: Vohnout
authors.forename: Peter
authors.initials: P
authors.lastname: Penz
authors.forename: Peter
authors.initials: P
authors.lastname: Kuka
authors.forename: Maria
authors.initials: M
authors.lastname: Bucova
authors.forename: Viera
authors.initials: V
authors.lastname: Kosmalova
authors.forename: Mustafa
authors.initials: M
authors.lastname: Atalay
mesh_terms: D000328:Adult; D000368:Aged; D060050:Angina, Stable / Q000097:blood / Q000276:immunology* / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D018834:Chaperonin 60 / Q000097:blood; D018932:Chemokine CCL2 / Q000097:blood; D004417:Dyspnea / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D017079:Exercise Tolerance / Q000276:immunology*; D005260:Female; D019803:Glutathione Disulfide / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D037601:Mannose-Binding Lectin / Q000097:blood; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000276:immunology* / Q000503:physiopathology*; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; D018834:Chaperonin 60; D018932:Chemokine CCL2; C508600:IL6 protein, human; D015850:Interleukin-6; D037601:Mannose-Binding Lectin; D053773:Transforming Growth Factor beta1; D002097:C-Reactive Protein; D019803:Glutathione Disulfide