title: Correlation of intestinal microbiota with overweight and obesity in Kazakh school children.
abstract: BACKGROUND
  This study sought to investigate a possible correlation between the intestinal microbiota, Bacteroidetes and Firmicutes, and obesity in Kazakh school children, aged 7-13 (n = 175).
  
  
  RESULTS
  Obese subjects had significantly greater systolic blood pressure, waist and hip circumference, as well as HOMA-IR as compared to normal and overweight participants. In addition, Bacteroides copy number and Bact/Firm ratios were significantly lower in the obese group as compared to the normal and overweight groups (P < 0.0167). This difference is only significant in girls, but not in boys when stratified by gender. Furthermore, a negative correlation between BMI and Bacteroidetes copy number (r = -0.18, P = 0.017) as well as Bact/Firm (r = -0.22, P = 0.003) was observed.
  
  
  CONCLUSIONS
  An association between reduced gut Bacteroidetes and Bact/Firm ratio with obesity in female Kazakh children was identified. Further studies are necessary to elucidate the mechanism behind these changes as well as the value of determining their presence for predicting obesity.
authors.affiliation: Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region, People's Republic of China. xupeiru126@126.com
authors.forename: Peiru
authors.initials: P
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Jihong
authors.initials: J
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D058491:Bacterial Load; D041963:Bacteroidetes / Q000302:isolation & purification*; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006094:Gram-Positive Bacteria / Q000302:isolation & purification*; D006801:Humans; D007623:Kazakhstan; D008297:Male; D054892:Metagenome; D050177:Overweight / Q000382:microbiology*; D012574:Schools; D013334:Students