title: Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level.
abstract: BACKGROUND
  E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals.
  
  
  METHODS
  Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed.
  
  
  RESULTS
  SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511).
  
  
  CONCLUSIONS
  SELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.
authors.affiliation: Department of Life Science, Chinese Culture University, Taipei, Taiwan.
authors.forename: Semon
authors.initials: S
authors.lastname: Wu
authors.forename: Lung-An
authors.initials: LA
authors.lastname: Hsu
authors.forename: Ming-Sheng
authors.initials: MS
authors.lastname: Teng
authors.forename: Jeng-Feng
authors.initials: JF
authors.lastname: Lin
authors.forename: Hsien-Hsun
authors.initials: HH
authors.lastname: Chang
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Sun
authors.forename: Hsuan-Pu
authors.initials: HP
authors.lastname: Chen
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Ko
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D019040:E-Selectin / Q000097:blood / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D016014:Linear Models; D015810:Linkage Disequilibrium; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D013624:Taiwan
chemical_list: D019040:E-Selectin; C546936:SELE protein, human; D020780:Matrix Metalloproteinase 9