title: Weight-loss diet alone or combined with progressive resistance training induces changes in association between the cardiometabolic risk profile and abdominal fat depots.
abstract: OBJECTIVE
  A weight-loss diet alone or combined with a progressive resistance training program induced different adaptations on cardiometabolic risk, i.e. regional changes in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volume distribution patterns. We hypothesized that a heterogeneous adipose tissue metabolism may exist between visceral fat at different discal levels.
  
  
  METHODS
  Thirty-four obese women, aged 40-60 years, were randomized to three groups: a control group (n = 9), a diet group (WL; n = 12) with a caloric restriction of 500 kcal/day during 16 weeks, or a diet-plus-resistance-training group (WL+RT; n = 13) with the same caloric restriction and a 16-week resistance training of 2 sessions per week.
  
  
  RESULTS
  The association pattern between abdominal fat depots and glucose metabolism variables showed a change from the L4-L5 region (preintervention) to VAT L2-L3 and SAT L2-L3 in the WL and WL+RT groups, respectively. It is noteworthy that accumulation of fat in the midthigh was not characterized by a more favorable lipid profile or glucose metabolism.
  
  
  CONCLUSIONS
  Our results reinforce the importance of considering L2-L3 images to predict insulin resistance after a weight-loss diet, alone or combined with resistance training.
authors.affiliation: Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain.
authors.forename: Marisol
authors.initials: M
authors.lastname: García-Unciti
authors.forename: Mikel
authors.initials: M
authors.lastname: Izquierdo
authors.forename: Fernando
authors.initials: F
authors.lastname: Idoate
authors.forename: Esteban
authors.initials: E
authors.lastname: Gorostiaga
authors.forename: Ana
authors.initials: A
authors.lastname: Grijalba
authors.forename: Francisco
authors.initials: F
authors.lastname: Ortega-Delgado
authors.forename: Cristina
authors.initials: C
authors.lastname: Martínez-Labari
authors.forename: José M
authors.initials: JM
authors.lastname: Moreno-Navarrete
authors.forename: Lluis
authors.initials: L
authors.lastname: Forga
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fernández-Real
authors.forename: Javier
authors.initials: J
authors.lastname: Ibáñez
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D031204:Caloric Restriction; D002318:Cardiovascular Diseases / Q000178:diet therapy*; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004038:Diet, Reducing; D002149:Energy Intake / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy; D055070:Resistance Training / Q000379:methods*; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000378:metabolism
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin