title: Immunological manifestations in type I diabetic children.
abstract: In the past decade a number of studies suggested that type 1 diabetes mellitus is an oxidative stress influenced disease. Paraoxonase 1 enzyme plays a crucial role in antiatherogenic-antioxidant circle. The aim of our study was to examine the possible differences in paraoxonase 1 enzymatic activities in diabetic children associated other autoimmune diseases versus a control group. Another objective of the study was to determine if there is any difference according to the gender in paraoxonase 1 activities (arylesterase and paraoxonase activities). Paraoxonase 1 activities were determined in 51 diabetic children and 36 healthy controls. In diabetic children we determined also the C-peptide level. The paraoxonase 1 arylesterase activity was lower in diabetic females compared with diabetic males. The level of C-peptide is in an inverse correlation with the years of the disease. The paraoxonase activities have a correlation with the level of insulin antibodies in type I diabetic children. Our data suggest that paraoxonase enzymatic pattern may be different in these two activities. PON1 arylesterase activity may exhibit a tendency to low levels in women in comparison to men. The C-peptide level is a valuable tool in assessing the restant beta cell function.
authors.affiliation: Department of Pediatrics II, University of Medicine and Pharmacy "luliu Haţieganu" Cluj-Napoca, Romania.
authors.forename: Andreea Liana
authors.initials: AL
authors.lastname: Răchişan
authors.forename: Bianca Andreea
authors.initials: BA
authors.lastname: David
authors.forename: Simona
authors.initials: S
authors.lastname: Căinap
authors.forename: Nicolae
authors.initials: N
authors.lastname: Miu
authors.forename: Mariana
authors.initials: M
authors.lastname: Andreica
authors.forename: Gabriel
authors.initials: G
authors.lastname: Samaşca
mesh_terms: D000293:Adolescent; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D002096:C-Peptide / Q000032:analysis; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology* / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D002096:C-Peptide; D043303:Aryldialkylphosphatase