title: Polymethoxyflavones as agents that prevent formation of cataract: nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells.
abstract: Posterior capsular opacification (PCO) is the most frequent complication and the primary reason for visual decrease after extracapsular cataract surgery. The proliferation and migration of leftover lens epithelial cells (LECs) after surgery may contribute to the development of PCO. To prevent PCO, a rational approach would be to inhibit both the proliferation and the migration of LECs using nontoxic xenobiotics. Nobiletin, one of the most abundant polymethoxyflavones (PMFs) in citrus peel, and its synthetic congeners displayed a potent inhibition of LEC proliferation. Structural features which enhance anti-proliferative activity have also been discussed.
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Miyata
authors.forename: Tetsuta
authors.initials: T
authors.lastname: Oshitari
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okuyama
authors.forename: Arata
authors.initials: A
authors.lastname: Shimada
authors.forename: Hideyo
authors.initials: H
authors.lastname: Takahashi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Natsugari
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kosano
mesh_terms: D002386:Cataract / Q000517:prevention & control; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002957:Citrus / Q000737:chemistry; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects*; D047309:Flavones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007908:Lens, Crystalline / Q000166:cytology; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D047309:Flavones; C008661:nobiletin; D020780:Matrix Metalloproteinase 9