title: Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites.
abstract: Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8-10 nm), circular plasmid DNA (~4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.
authors.affiliation: Institute of Creativity and Department of Chemistry, The Hong Kong Baptist University, Kowloon, Hong Kong SAR, P. R. China. cfleung@hkbu.edu.hk
authors.forename: Ken Cham-Fai
authors.initials: KC
authors.lastname: Leung
authors.forename: Chun-Pong
authors.initials: CP
authors.lastname: Chak
authors.forename: Siu-Fung
authors.initials: SF
authors.lastname: Lee
authors.forename: Josie M Y
authors.initials: JM
authors.lastname: Lai
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhu
authors.forename: Yi-Xiang J
authors.initials: YX
authors.lastname: Wang
authors.forename: Kathy W Y
authors.initials: KW
authors.lastname: Sham
authors.forename: Christopher H K
authors.initials: CH
authors.lastname: Cheng
mesh_terms: D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D003676:Deferoxamine / Q000737:chemistry*; D018014:Gene Transfer Techniques; D005909:Glioblastoma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry* / Q000378:metabolism; D011094:Polyethyleneimine / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D011094:Polyethyleneimine; D003676:Deferoxamine