title: In vivo T-cell depletion with antithymocyte globulins improves overall survival after myeloablative allogeneic stem cell transplantation in patients with hematologic disorders.
abstract: To assess the effect of prophylactic treatment with antithymocyte globulin (ATG) on graft-versus-host disease (GvHD) in myeloablative transplant patients, we performed a meta-analysis of randomized and cohort studies. Medline, Embase, the Cochrane Controlled Trial Register and the Science Citation Index were searched for studies on ATG treatment in patients with hematologic disorders undergoing myeloablative transplantation. Four randomized controlled trials, six retrospective and one prospective cohort study were included, covering 1,549 patients. The summary hazard ratios (HRs) for overall survival were 0.84.
authors.affiliation: Shandong University, Jinan, PR China.
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Sheng
authors.forename: Huanwen
authors.initials: H
authors.lastname: Ma
authors.forename: Wenzheng
authors.initials: W
authors.lastname: Pang
authors.forename: Shanona
authors.initials: S
authors.lastname: Niu
authors.forename: Jingbo
authors.initials: J
authors.lastname: Xu
mesh_terms: D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D018572:Disease-Free Survival; D005260:Female; D006086:Graft vs Host Disease / Q000401:mortality / Q000628:therapy; D006402:Hematologic Diseases / Q000401:mortality / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008212:Lymphocyte Depletion / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D033581:Stem Cell Transplantation; D015996:Survival Rate; D013601:T-Lymphocytes; D014184:Transplantation, Homologous
chemical_list: D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents