title: Introducing ligand-based hydrogen bond donors to a receptor: both selectivity and binding affinity for anion recognition in water can be improved.
abstract: Introducing hydrogen bond donors to a receptor was found to be an effective approach to improve both its selectivity and binding affinity for pyrophosphate in water. The crystal structure of Zn3-ADP complex showed the improvements come from the combination of H-bonding and metal coordination in a manner similar to many metalloenzymes.
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University,152 Luoyu Road, Wuhan 430079, P. R. China.
authors.forename: Feihu
authors.initials: F
authors.lastname: Huang
authors.forename: Chen
authors.initials: C
authors.lastname: Cheng
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Feng
mesh_terms: D011756:Diphosphates / Q000737:chemistry*; D006860:Hydrogen Bonding; D008024:Ligands; D013379:Substrate Specificity; D014867:Water / Q000737:chemistry*
chemical_list: D011756:Diphosphates; D008024:Ligands; D014867:Water