title: Life threatening hyperkalemia chronic kidney diseases patients treated with trimethoprim-sulfamethoxazole: a case series.
abstract: We report a case series of patients that develop severe life threatening hyperkalemia after use of a commonly prescribe oral antibiotic, Trimethoprim-Sulfamethoxazole. The three patients required acute hemodialysis to normalize serum potassium levels after development of hypotension and heart block due to hyperkalemia. All had preexisting chronic kidney disease. Some of them were on medications that interfere with the effects of aldosterone. Patients with chronic kidney disease, particularly those receiving other medications that may also contribute to the development of hyperkalemia, should be closely monitored for this complication when Trimethoprim-containing antibiotic is needed. In these cases, other antibiotic therapy alternatives should be considered.
authors.affiliation: Renal Section, Department of Medicine, Veterans Affairs Caribbean Health Care System, San Juan, Puerto Rico.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Calderón-Ortiz
authors.forename: Pedro
authors.initials: P
authors.lastname: Colton-Verge
authors.forename: Myrna
authors.initials: M
authors.lastname: Muñiz-Ortega
authors.forename: Laura
authors.initials: L
authors.lastname: Lespier
authors.forename: Héctor
authors.initials: H
authors.lastname: Córdova
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects*; D004630:Emergencies; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced*; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000139:chemically induced*; D012720:Severity of Illness Index; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination