title: Preeclampsia and ABO blood groups: a systematic review and meta-analysis.
abstract: Preeclampsia (PE) is a multifactorial pregnancy-specific syndrome which represents one of the leading causes of maternal mortality worldwide. Inherited thrombophilia have been investigated as risk factor for the development of PE and it is currently known that ABO blood group may impact haemostatic balance, having the non-O blood groups (A, B or AB) subjects increased risk for thrombus formation, as compared to those of group O. We performed a systematic review of the literature for published studies investigating whether ABO blood groups could influence PE developing. A sensitive search of four databases identified 45 unique titles. The retrieved papers were assessed independently by authors and a rigorous process of selection and data extract was conduct. Methodological quality of the included studies was also evaluated. Two studies met eligibility criteria. As a main finding of our systematic review, an association between the AB blood group and the occurrence of PE was detected based on two original studies. Considering the role of ABO blood groups on the hemostatic process and thrombus formation, special attention should be given to pregnant patients carrying the AB blood group in order to prevent the syndrome and improve prognosis.
authors.affiliation: Department of Clinical and Toxicological Analyses, School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
authors.forename: Patricia Nessralla
authors.initials: PN
authors.lastname: Alpoim
authors.forename: Melina
authors.initials: M
authors.lastname: de Barros Pinheiro
authors.forename: Daniela Rezende Garcia
authors.initials: DR
authors.lastname: Junqueira
authors.forename: Leticia Gonçalves
authors.initials: LG
authors.lastname: Freitas
authors.forename: Maria
authors.initials: M
authors.lastname: das Graças Carvalho
authors.forename: Ana Paula Salles Moura
authors.initials: AP
authors.lastname: Fernandes
authors.forename: Flávia
authors.initials: F
authors.lastname: Komatsuzaki
authors.forename: Karina Braga
authors.initials: KB
authors.lastname: Gomes
authors.forename: Luci Maria
authors.initials: LM
authors.lastname: Sant'Ana Dusse
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D005260:Female; D006801:Humans; D016017:Odds Ratio; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D000017:ABO Blood-Group System