title: Utility of rigid bronchoscopic dilatation and mitomycin C application in the management of postintubation tracheal stenosis: case series and systematic review of literature.
abstract: BACKGROUND
  Postintubation tracheal stenosis (PITS) is a common problem encountered by interventional pulmonologists. The aim of this study was to evaluate the utility of mitomycin C (MMC) as an adjunctive treatment to rigid bronchoscopic dilatation in patients with PITS.
  
  
  METHODS
  Prospective analysis of data from the interventional pulmonology unit of a large tertiary care teaching center in North India. Patients with a diagnosis of PITS undergoing rigid bronchoscopic dilatation and MMC (0.4 mg/mL) application were included. The primary outcome was the occurrence of restenosis.
  
  
  RESULTS
  Seven patients underwent rigid bronchoscopic dilatation, followed by the application of MMC at 4 quadrants of the stenosis. Controlled radial expansion balloon bronchoplasty was also performed, if necessary, in addition to mechanical dilatation using the barrel of the rigid bronchoscope. Restenosis occurred in all 7 patients (100%) and the mean duration to the detection of restenosis was 27 days. The restenosis was symptomatic in 6 out of 7 (85.7%) patients.
  
  
  CONCLUSIONS
  Rigid bronchoscopic dilatation and a single application of MMC is not an effective treatment in the management of PITS.
authors.affiliation: Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Karan
authors.initials: K
authors.lastname: Madan
authors.forename: Ritesh
authors.initials: R
authors.lastname: Agarwal
authors.forename: Ashutosh N
authors.initials: AN
authors.lastname: Aggarwal
authors.forename: Dheeraj
authors.initials: D
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D000328:Adult; D060666:Airway Extubation / Q000009:adverse effects; D001999:Bronchoscopy / Q000379:methods*; D003131:Combined Modality Therapy; D004106:Dilatation / Q000379:methods*; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D011446:Prospective Studies; D019141:Respiratory System Agents / Q000008:administration & dosage*; D055502:Secondary Prevention; D014135:Tracheal Stenosis / Q000628:therapy*; D055815:Young Adult
chemical_list: D019141:Respiratory System Agents; D016685:Mitomycin