title: A monoclonal expansion of Epstein-Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation.
abstract: Here, we describe a Japanese woman showing a monoclonal expansion of EBV-infected natural killer (NK) cells after receiving allogeneic peripheral blood stem cell transplantation (PBSCT). The patient initially had T-cell-type chronic active EBV disease (CAEBV) and subsequently developed liver T-cell lymphoma. L-Asparaginase-containing chemotherapy led to a favorable lymphoma response. To eradicate CAEBV and the lymphoma, she further received allogeneic PBSCT from a human leukocyte antigen-matched sibling donor. After the PBSCT, the patient presented with transient lymphocytosis of NK cells, which were infected with a monoclonal EBV strain other than previously detected ones. These NK cells seemed to have been transmitted from the healthy donor to the recipient. The patient and donor remain well in spite of carrying these NK cells. This is the first report of an asymptomatic Japanese carrier harboring monoclonal EBV-infected NK cells.
authors.affiliation: Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan. yisobe@marianna-u.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Isobe
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Hamano
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tsukada
authors.forename: Koichi
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Norio
authors.initials: N
authors.lastname: Komatsu
mesh_terms: D002353:Carrier State / Q000821:virology; D049109:Cell Proliferation; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007694:Killer Cells, Natural / Q000821:virology*; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D055815:Young Adult