title: Concise review: stem cell therapy for muscular dystrophies.
abstract: Muscular dystrophy comprises a group of genetic diseases that cause progressive weakness and degeneration of skeletal muscle resulting from defective proteins critical to muscle structure and function. This leads to premature exhaustion of the muscle stem cell pool that maintains muscle integrity during normal use and exercise. Stem cell therapy holds promise as a treatment for muscular dystrophy by providing cells that can both deliver functional muscle proteins and replenish the stem cell pool. Here, we review the current state of research on myogenic stem cells and identify the important challenges that must be addressed as stem cell therapy is brought to the clinic.
authors.affiliation: Department of Pediatrics, University of California, CA, USA.
authors.forename: Karlijn J
authors.initials: KJ
authors.lastname: Wilschut
authors.forename: Vivian B
authors.initials: VB
authors.lastname: Ling
authors.forename: Harold S
authors.initials: HS
authors.lastname: Bernstein
mesh_terms: D002455:Cell Division; D002986:Clinical Trials as Topic; D006801:Humans; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000166:cytology / Q000502:physiology; D009136:Muscular Dystrophies / Q000628:therapy*; D039904:Pluripotent Stem Cells / Q000637:transplantation*; D012038:Regeneration; D032496:Satellite Cells, Skeletal Muscle / Q000637:transplantation*; D033581:Stem Cell Transplantation