title: Iron-catalyzed oxidative amidation of tertiary amines with aldehydes.
abstract: Unconventional couple: A new oxidative coupling protocol for amide bond formation has been developed (see scheme). The method provides an efficient and practical route for the synthesis of tertiary amides from readily available tertiary amines and aldehydes in the presence of a simple FeCl(2) catalyst. Mechanistic studies indicated that a peroxide and an iminium ion act as the reactive intermediates in this oxidative amidation.
authors.affiliation: Department of Chemistry, Renmin University of China, Beijing 100872, PR China.
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Li
authors.forename: Fan
authors.initials: F
authors.lastname: Jia
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Li
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000447:Aldehydes; D000577:Amides; D000588:Amines; D007501:Iron