title: Glycated proteome: from reaction to intervention.
abstract: Glycation, a nonenzymatic reaction between reducing sugars and proteins, is a proteome wide phenomenon, predominantly observed in diabetes due to hyperglycemia. Glycated proteome of plasma, kidney, lens, and brain are implicated in the pathogenesis of various diseases, including diabetic complications, neurodegenerative diseases, cancer, and aging. This review discusses the strategies to characterize protein glycation, its functional implications in different diseases, and intervention strategies to protect the deleterious effects of protein glycation.
authors.affiliation: Proteomics Facility, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India. mj.kulkarni@ncl.res.in
authors.forename: Mahesh J
authors.initials: MJ
authors.lastname: Kulkarni
authors.forename: Arvind M
authors.initials: AM
authors.lastname: Korwar
authors.forename: Sheon
authors.initials: S
authors.lastname: Mary
authors.forename: Hemangi S
authors.initials: HS
authors.lastname: Bhonsle
authors.forename: Ashok P
authors.initials: AP
authors.lastname: Giri
mesh_terms: D000818:Animals; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006031:Glycosylation / Q000187:drug effects; D006801:Humans; D020543:Proteome / Q000737:chemistry / Q000378:metabolism*; D040901:Proteomics
chemical_list: D017127:Glycation End Products, Advanced; D020543:Proteome