title: Ameliorating effect of Semecarpus anacardium Linn. nut milk extract on altered glucose metabolism in high fat diet STZ induced type 2 diabetic rats.
abstract: OBJECTIVE
  To explore the protective effect of the drug Semecarpus anacardium (S. anacardium)on altered glucose metabolism in diabetic rats.
  
  
  METHODS
  Type 2 diabetes mellitus was induced by feeding rats with high fat diet followed by single intraperitoneal injection of streptozotocin (STZ) (35 mg/kg b.w.). Seven days after STZ induction, diabetic rats received nut milk extract of S. anacardium Linn. nut milk extract orally at a dosage of 200 mg/kg daily for 4 weeks. The effect of nut milk extract of S. anacardium on blood glucose, plasma insulin, glucose metabolising enzymes and GSK were studied.
  
  
  RESULTS
  Treatment with SA extract showed a significant reduction in blood glucose levels and increase in plasma insulin levels and also increase in HOMA - β and decrease in HOMA -IR. The drug significantly increased the activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase activity and increased the glycogen content in liver of diabetic rats while reducing the activities of gluconeogenic enzymes. The drug also effectively ameliorated the alterations in GSK-3 mRNA expression.
  
  
  CONCLUSIONS
  Overall, the present study demonstrates the possible mechanism of glucose regulation of S. anacardium suggestive of its therapeutic potential for the management of diabetes mellitus.
authors.affiliation: Department of Medical Biochemistry, DR. A.L.M. P-G. I.B.M.S., University of Madras, Taramani Campus, Chennai - 600 113. India.
authors.forename: Haseena Banu Hedayathullah
authors.initials: HB
authors.lastname: Khan
authors.forename: Kaladevi Siddhi
authors.initials: KS
authors.lastname: Vinayagam
authors.forename: Shanthi
authors.initials: S
authors.lastname: Palanivelu
authors.forename: Sachdanandam
authors.initials: S
authors.lastname: Panchanadham
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy* / Q000378:metabolism; D059305:Diet, High-Fat; D015870:Gene Expression / Q000187:drug effects; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D006706:Homeostasis; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells; D008297:Male; D009754:Nuts / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D031023:Semecarpus / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts; D038362:Glycogen Synthase Kinase 3