title: Honeycomb patterned surfaces functionalized with polypeptide sequences for recognition and selective bacterial adhesion.
abstract: We report on the preparation of functional polymer surfaces with controlled topography by using the breath figures approach. The resulting surfaces prepared from a mixture of a PS-b-PAA diblock copolymer and a homopolymer (PS) exhibit pores that are mainly composed of diblock copolymer whereas the rest of the surface is formed by homopolymer. The formation of a hexagonal assembly of pores was achieved by controlling several parameters during the casting process including relative humidity, composition of the blend and polymer concentration. A selective modification of the pore inner part by using appropriate polypeptide sequences permitted the use of these surfaces as scaffolds for pattern and display of active biomolecules, as ordered templates for specific recognition processes and finally for the micropatterning of bacterial cells.
authors.affiliation: Instituto de Ciencia y Tecnología de Polímeros-ICTP-CSIC, Chemistry and Properties of Polymeric Materials Department, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Sanz de León
authors.forename: Juan
authors.initials: J
authors.lastname: Rodríguez-Hernández
authors.forename: Aitziber L
authors.initials: AL
authors.lastname: Cortajarena
mesh_terms: D000595:Amino Acid Sequence; D001422:Bacterial Adhesion / Q000502:physiology*; D002469:Cell Separation / Q000379:methods*; D004926:Escherichia coli / Q000166:cytology* / Q000502:physiology*; D008422:Materials Testing; D054802:Molecular Imprinting / Q000379:methods*; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties
chemical_list: D010455:Peptides