title: Novel threadlike structures on the surfaces of mammalian abdominal organs are loose bundles of fibrous stroma with microchannels embedded with fibroblasts and inflammatory cells.
abstract: Novel threadlike structures (NTSs) on the surfaces of mammalian abdominal organs have recently attracted interests regarding their ability to transport fluid, enable cell migration, and possibly facilitate cancer metastasis. Nevertheless, histological studies of NTSs have been sporadic and often have inconsistent interpretations of the NTS internal structure. In this article, we provide a synthetic and consistent view of the NTS internal structure: the NTS is a loose bundle of fibrous stroma that forms interstitial channels and microsinusoids infiltrated with inflammatory cells. The fibroblasts are embedded in the stroma and mostly aligned along the major axis of the NTS. The sinusoids, which are in inconsecutive cross sections, have boundaries more or less delineated by extracellular fibers, partly surrounded by endothelial-like cells, or both. We compare these morphological features to other well-known connective tissues (i.e., trabecular meshwork and lymphatic capillary) and discuss the biomechanical and biological functions of NTSs based on their structural characteristics.
authors.affiliation: Pharmacopuncture Medical Research Institute, Seoul, Korea.
authors.forename: Byung-Cheon
authors.initials: BC
authors.lastname: Lee
authors.forename: Baeckkyoung
authors.initials: B
authors.lastname: Sung
authors.forename: Ki-Hoon
authors.initials: KH
authors.lastname: Eom
authors.forename: Eun-Sung
authors.initials: ES
authors.lastname: Park
authors.forename: Min Su
authors.initials: MS
authors.lastname: Kim
authors.forename: Se Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Vyacheslav
authors.initials: V
authors.lastname: Ogay
authors.forename: Ki Woo
authors.initials: KW
authors.lastname: Kim
authors.forename: Yeonhee
authors.initials: Y
authors.lastname: Ryu
authors.forename: Yeo-Sung
authors.initials: YS
authors.lastname: Yoon
authors.forename: Kwang-Sup
authors.initials: KS
authors.lastname: Soh
mesh_terms: D034841:Abdominal Cavity / Q000033:anatomy & histology*; D000818:Animals; D005347:Fibroblasts / Q000166:cytology* / Q000648:ultrastructure; D007249:Inflammation / Q000473:pathology*; D008322:Mammals / Q000033:anatomy & histology*; D008566:Membranes / Q000648:ultrastructure; D009928:Organ Specificity; D011817:Rabbits; D017154:Stromal Cells / Q000166:cytology / Q000648:ultrastructure