title: [Characteristics of H. pylori-negative gastric cancer].
abstract: Helicobacter pylori-negative gastric cancer (HpNGC) is known as a rare disease. We demonstrated its prevalence was less than 1% of all gastric cancers in Japan. Patients with HpNGC were younger, and not as predominantly male. The prevalence of diffuse type histology (especially signet ring cell carcinoma) and superficial depressed appearance was significantly higher than ordinary gastric cancer. A half of HpNGCs expressed intestinal type mucus as well as gastric type. Along with the decrease of Hp infection and widespread of eradication therapy, the incidence of gastric cancer will dramatically decrease in the future.
authors.affiliation: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Ito
authors.forename: Taiji
authors.initials: T
authors.lastname: Matsuo
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Chayama
mesh_terms: D018279:Carcinoma, Signet Ring Cell / Q000473:pathology; D005260:Female; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000382:microbiology* / Q000473:pathology*