title: Aldol reactions mediated by a tetrahedral boronate.
abstract: The base is a key factor in aldol reactions in organic media, determining the selectivity. Here, we describe a tetrahedral phenylboronate salt as a mild non-nucleophilic base that is able to catalyse the aldol reaction and significantly decrease the formation of undesired elimination products.
authors.affiliation: Biokatalyse & Organische Chemie, Gebouw voor Scheikunde, Afdeling Biotechnologie, Technische Universiteit Delft, Julianalaan 136, 2628BL Delft, The Netherlands.
authors.forename: Tobias
authors.initials: T
authors.lastname: Müller
authors.forename: Kristina
authors.initials: K
authors.lastname: Djanashvili
authors.forename: Isabel W C E
authors.initials: IW
authors.lastname: Arends
authors.forename: Joop A
authors.initials: JA
authors.lastname: Peters
authors.forename: Ulf
authors.initials: U
authors.lastname: Hanefeld
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry
chemical_list: D000447:Aldehydes; D001897:Boronic Acids; D009930:Organic Chemicals; C116609:3-hydroxybutanal; C010686:benzeneboronic acid