title: Clerodane diterpenoids from Croton crassifolius.
abstract: Seven new clerodane diterpenoids (1-7) were isolated from roots of Croton crassifolius, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of 1, 3, 4, and 7 were confirmed by single-crystal X-ray diffraction analyses. Compounds 1-13 were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.forename: Jia-Gui
authors.initials: JG
authors.lastname: Li
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Li
authors.forename: Jiao-Jiao
authors.initials: JJ
authors.lastname: Xu
authors.forename: Xia
authors.initials: X
authors.lastname: Wu
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D029802:Croton / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D003603:Cytotoxins; D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal