title: [Significant two-weeks clinical efficacy of an association between Massaciuccoli peat and sodium chloride water of Undulna Thermae measured on gynoid lipodystrophy in a group of overweight female].
abstract: BACKGROUND
  Peloid has been popularly used as an effective base in cosmetic preparations, although its biologically-active materials and mechanisms on skin have not yet been fully determined. An association between Massaciuccoli peat and sodium chloride water of Undulna Thermae was evaluated as a 2-weeks therapy for gynoid lipodystrophy in a group of 30 overweight females (age: 20-50y, BMI: 25-35 kg/m2) by means of evidence based-medicine criteria.
  
  
  METHODS
  The modification of the body diameters was the primary end-point, and the variation of skinfold thicknesses, bioimpendance parameters, evaluation of skin elasticity, rated thermal contact to liquid crystals and measurement of subcutaneous fat tissue were the secondary end-points. It was asked, by visual-analog scale, for an opinion to the patients about effectiveness of treatment.
  
  
  RESULTS
  At the end of treatment, after 2 weeks, all body diameters significantly decreased in the intervention group (waist circumference: 91.95 +/- 8.94 versus 90.60 +/- 8.90 cm, p < 0.001). Moreover, total body water were significantly reduced in the intervention group (35.05 +/- 3.74 versus 34.38 +/- 3.41 l, p < 0.03). As regards skin elasticity (+5.52%, p < 0.001), significant improvements have been determined; subcutaneous perfusion was also improved and thickness of subcutaneous fat was significantly reduced (thighs delta = -1.3 mm, p < 0.01; abdomen delta = -4.6 mm, p < 0.001). Furthermore, response to the visual-analog scale was positive (7.55 +/- 0.87).
  
  
  CONCLUSIONS
  This treatment appears potentially useful in the clinical management of gynoid lipodystrophy in overweight females.
authors.affiliation: Department of Applied Health Sciences, Section of Human Nutrition and Dietetics, University of Pavia, Italy. mariangela.rondanelli@unipv.it
authors.forename: M
authors.initials: M
authors.lastname: Rondanelli
authors.forename: A
authors.initials: A
authors.lastname: Opizzi
authors.forename: S
authors.initials: S
authors.lastname: Perna
authors.forename: M A
authors.initials: MA
authors.lastname: Faliva
authors.forename: D
authors.initials: D
authors.lastname: Buonocore
authors.forename: G
authors.initials: G
authors.lastname: Pezzoni
authors.forename: A
authors.initials: A
authors.lastname: Michelotti
authors.forename: R
authors.initials: R
authors.lastname: Marchetti
authors.forename: F
authors.initials: F
authors.lastname: Marzatico
mesh_terms: D000328:Adult; D001452:Balneology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008060:Lipodystrophy / Q000209:etiology / Q000628:therapy*; D008900:Mineral Waters / Q000627:therapeutic use*; D009094:Mud Therapy; D050177:Overweight / Q000150:complications; D012965:Sodium Chloride / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D008900:Mineral Waters; D012965:Sodium Chloride