title: Minimal change nephrotic syndrome associated with invasive thymoma: a case report with literature review.
abstract: The present report describes a case of nephrotic syndrome (NS) with invasive thymoma. A male patient was hospitalized for severe edema with reduced urine output. He had a history of thymectomy and radiotherapy because of invasive thymoma 4 years before the development of NS. Renal biopsy displayed minimal change disease (MCD). Although imaging study showed probably recurrent sign of invasive thymoma, the patient still received steroid monotherapy for ~ 9 months and he got partial remission of NS at the 8th week. Therefore, we suggest that MCD should be taken into account as a pathological lesion type in old NS patients with thymoma. In spite of longer remission time, steroid monotherapy and combination therapy with immunosuppressant are effective for thymoma-associated MCD.
authors.forename: Quan
authors.initials: Q
authors.lastname: Long
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.forename: Gengru
authors.initials: G
authors.lastname: Jiang
authors.forename: Chun
authors.initials: C
authors.lastname: Zhu
mesh_terms: D001706:Biopsy; D003952:Diagnostic Imaging; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009402:Nephrosis, Lipoid / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D013945:Thymoma / Q000150:complications*; D013953:Thymus Neoplasms / Q000150:complications*
chemical_list: D005938:Glucocorticoids