title: Genetic susceptibility to pancreatic cancer and its functional characterisation: the PANcreatic Disease ReseArch (PANDoRA) consortium.
abstract: Pancreatic cancer is the fourth leading cause of cancer deaths in the European Union and in the USA, but little is known about its genetic susceptibility. The PANcreatic Disease ReseArch (PANDoRA) consortium was established to unite the efforts of different research groups; its aim is to create a large bio-database to uncover new genetic factors for pancreatic cancer risk, response to treatment, and patient survival. So far 2220 cases of pancreatic adenocarcinoma, a smaller number of cases of endocrine pancreatic tumours (n=86), chronic pancreatitis (n=272) and 3847 healthy controls have been collected. As a collective effort of the consortium, SNPs associated with pancreatic adenocarcinoma risk from a genome-wide association study performed in Caucasians were replicated. The possibility that the same genetic polymorphisms may influence patient survival as well was also addressed. This collective effort is particularly important for pancreatic cancer because it is a relatively rare disease for which little is known about aetiopathogenesis and risk factors. The recruitment of additional collaborators and partner institutions is continuously on-going.
authors.affiliation: German Cancer Research Center (DKFZ), Heidelberg, Germany. d.campa@dkfz.de
authors.forename: Daniele
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authors.lastname: Campa
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authors.lastname: Khaw
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authors.lastname: Malecka-Panas
authors.forename: Andrea
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authors.lastname: Mambrini
authors.forename: Franco
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authors.lastname: Bambi
authors.forename: Stefano
authors.initials: S
authors.lastname: Landi
authors.forename: Sergio
authors.initials: S
authors.lastname: Pedrazzoli
authors.forename: Claudio
authors.initials: C
authors.lastname: Bassi
authors.forename: Paola
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authors.lastname: Pacetti
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authors.lastname: Piepoli
authors.forename: Francesca
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authors.lastname: Tavano
authors.forename: Pierluigi
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authors.lastname: di Sebastiano
authors.forename: Ludmila
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authors.lastname: Vodickova
authors.forename: Daniela
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authors.lastname: Basso
authors.forename: Mario
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authors.lastname: Plebani
authors.forename: Paola
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authors.lastname: Fogar
authors.forename: Markus W
authors.initials: MW
authors.lastname: Büchler
authors.forename: Peter
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authors.lastname: Bugert
authors.forename: Pavel
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authors.lastname: Vodicka
authors.forename: Ugo
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authors.lastname: Boggi
authors.forename: John P
authors.initials: JP
authors.lastname: Neoptolemos
authors.forename: Jens
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authors.forename: Federico
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authors.lastname: Canzian
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors