title: Correlation of lipoprotein (a) concentration with the extent of coronary artery disease in patients on lipid lowering therapy.
abstract: OBJECTIVE
  Lipoprotein (a) [Lp(a)], together with other serum lipoproteins have an important role in the pathogenesis of coronary heart disease. The objective of the study was to assess the association between plasma levels of Lp(a) with the extent of angiographically defined coronary artery disease (CAD).
  
  
  METHODS
  A total of 518 consecutive patients (66 % males) underwent coronary angiography in connection with lipids and lipoprotein determinations between 1st January and 31st May 2010. Most of the patients were treated with lipid lowering therapy (77 % statins). Modified angiographic Gensini Score (GS) and adjusted angiographic score (AS) were used to reflect the extent of coronary atherosclerosis.
  
  
  RESULTS
  Both GS and AS angiographic scores correlated significantly with age, male gender, statin therapy and inversely with left ventricular ejection fraction (p<0.05-0.01 for all). The results showed significant inverse correlation of HDL cholesterol levels with GS and AS (r=-0.16, p<0.001), and apolipoprotein A levels with GS and AS (r=-0.20, p<0.0001) and a positive correlation of Lp(a) levels with angiographic score (r=0.13, p<0.01) and with adjusted angiographic score (r=0.16, p<0.01). Regression analysis showed only Lp(a) concentration was an independent lipid factor that correlated with the extent of CAD.
  
  
  CONCLUSIONS
  Only Lp(a) levels correlated with the extent of coronary artery disease as assessed with coronary angiography in patients treated with lipid lowering therapy.
authors.affiliation: Cardiovascular Center, Na Homolce Hospital, Prague, Czech Republic. filip.malek@centrum.cz
authors.forename: Filip
authors.initials: F
authors.lastname: Malek
authors.forename: Jan
authors.initials: J
authors.lastname: Dvorak
authors.forename: Jan
authors.initials: J
authors.lastname: Svitil
authors.forename: Vladimira
authors.initials: V
authors.lastname: Skalnikova
authors.forename: Martin
authors.initials: M
authors.lastname: Mates
authors.forename: Petr
authors.initials: P
authors.lastname: Kmonicek
authors.forename: Pavel
authors.initials: P
authors.lastname: Formanek
authors.forename: Ondrej
authors.initials: O
authors.lastname: Aschermann
authors.forename: Karel
authors.initials: K
authors.lastname: Kopriva
authors.forename: Petr
authors.initials: P
authors.lastname: Neuzil
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology*; D050171:Dyslipidemias / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D017270:Lipoprotein(a) / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D000960:Hypolipidemic Agents; D017270:Lipoprotein(a)