title: A thermally-stable enzyme detection assay that amplifies signal autonomously in water without assistance from biological reagents.
abstract: This Communication describes a thermally-stable small molecule and a corresponding assay strategy that autonomously amplifies a colorimetric signal when a specific enzyme biomarker is detected.
authors.affiliation: The Pennsylvania State University, 104 Chemistry Bldg., University Park, PA 16802, USA.
authors.forename: Kimy
authors.initials: K
authors.lastname: Yeung
authors.forename: Kyle M
authors.initials: KM
authors.lastname: Schmid
authors.forename: Scott T
authors.initials: ST
authors.lastname: Phillips
mesh_terms: D016227:Benzoquinones / Q000737:chemistry; D001681:Biological Assay / Q000379:methods*; D002374:Catalase / Q000737:chemistry*; D003124:Colorimetry; D004355:Drug Stability; D005696:Galactosidases / Q000737:chemistry; D006358:Hot Temperature; D007202:Indicators and Reagents / Q000737:chemistry; D012815:Signal Processing, Computer-Assisted; D014867:Water / Q000737:chemistry*
chemical_list: D016227:Benzoquinones; D007202:Indicators and Reagents; D014867:Water; C054093:2-hydroxy-1,4-benzoquinone; D002374:Catalase; D005696:Galactosidases