title: Three-dimensional sonographic examination of the midbrain for computer-aided diagnosis of movement disorders.
abstract: We present a novel approach to transcranial B-mode sonography for Parkinson's disease (PD) diagnosis by using 3-D ultrasound (3-DUS). We reconstructed bilateral 3-DUS volumes of the midbrain and substantia nigra echogenicities (SNE) and report results of a more objective abnormality detection in (PD). For classification, we analyzed volumetric measurements of midbrain and SNE in subjects with PD and healthy controls (HC). After blinded segmentation of these structures in 22/23 subjects (11 PD, 11 HC) and by two observers with varying prior experience in this technique, the classification algorithm yielded up to 91% sensitivity and 64% specificity using the larger volume of both SNE as a single-dimensional features and up to 90.9% sensitivity and 72.7% specificity using a multidimensional feature set with midbrain and both SNE volumes. This pilot study indicates that our TC-3-D-US approach is technically feasible and less dependent on the investigator's experience and good bone windows. Our pilot study yielded a fairly high sensitivity and specificity in differentiating between subjects with PD and HC.
authors.affiliation: Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany. Annika.Plate@med.uni-muenchen.de
authors.forename: Annika
authors.initials: A
authors.lastname: Plate
authors.forename: Seyed-Ahmad
authors.initials: SA
authors.lastname: Ahmadi
authors.forename: Olivier
authors.initials: O
authors.lastname: Pauly
authors.forename: Tassilo
authors.initials: T
authors.lastname: Klein
authors.forename: Nassir
authors.initials: N
authors.lastname: Navab
authors.forename: Kai
authors.initials: K
authors.lastname: Bötzel
mesh_terms: D000465:Algorithms; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D008636:Mesencephalon / Q000000981:diagnostic imaging*; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D013378:Substantia Nigra / Q000000981:diagnostic imaging*; D017585:Ultrasonography, Doppler, Transcranial