title: An additional LDL-lowering effect of amlodipine; not only an antihypertensive?
abstract: Hypertension is a modifiable risk factor for cardiovascular diseases and is associated with several metabolic disorders like dyslipidemia. Higher levels of triglyceride and low-density lipoprotein (LDL) are quite strong factors for the development of cardiovascular diseases. In this study, we investigated the effects of valsartan and amlodipine on the lipid profile in patients with newly diagnosed essential hypertension. We observed a beneficial effect of amlodipine on the lipid profile with a significant reduction of LDL compared to valsartan. In the treatment of hypertension, prior knowledge of the plasma cholesterol levels can be important in antihypertensive drug choice.
authors.affiliation: Department of Cardiology, Gelibolu Hospital , Canakkale , Turkey.
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Arslan
authors.forename: Seyit Ahmet
authors.initials: SA
authors.lastname: Ay
authors.forename: Murat
authors.initials: M
authors.lastname: Karaman
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cakar
authors.forename: Turgay
authors.initials: T
authors.lastname: Celik
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.forename: Muharrem
authors.initials: M
authors.lastname: Akhan
authors.forename: Hakan
authors.initials: H
authors.lastname: Sarlak
authors.forename: Erol
authors.initials: E
authors.lastname: Arslan
authors.forename: Seref
authors.initials: S
authors.lastname: Demirbas
authors.forename: Sait
authors.initials: S
authors.lastname: Demirkol
authors.forename: Fatih
authors.initials: F
authors.lastname: Bulucu
authors.forename: Kenan
authors.initials: K
authors.lastname: Saglam
mesh_terms: D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000627:therapeutic use*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000150:complications / Q000188:drug therapy; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013777:Tetrazoles / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood; D014633:Valine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000068756:Valsartan
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D013777:Tetrazoles; D014280:Triglycerides; D017311:Amlodipine; D000068756:Valsartan; D002784:Cholesterol; D014633:Valine