title: Synthesis of indeno[1,2-c]furans via a Pd-catalyzed bicyclization of 2-alkynyliodobenzene and propargylic alcohol.
abstract: A general and efficient synthesis of indeno[1,2]furans via a Pd-catalyzed bicyclization reaction between 2-alkynyliodobenzenes and propargylic alcohols is described. The procedure furnishes indeno[1,2]furans with moderate to excellent yields (51%-78%) and a broad substrate scope. The cascade process combines the formation of one C-O bond and two C-C bonds in a single step.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
authors.forename: Jisong
authors.initials: J
authors.lastname: Jin
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Chen
authors.forename: Qiaodong
authors.initials: Q
authors.lastname: Wen
authors.forename: Ping
authors.initials: P
authors.lastname: Lu
authors.forename: Yanguang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*
chemical_list: D000480:Alkynes; D005663:Furans; D020005:Propanols; D010165:Palladium; C028255:propargyl alcohol; D001554:Benzene