title: Quadrantal macular retinal thickness changes in strabismus subjects with abnormal binocular vision development.
abstract: OBJECTIVE
  To investigate retinal morphological changes in strabismus patients with abnormal binocular vision development by comparing differences in quadrantal macular retinal thickness.
  
  
  METHODS
  Six strabismus patients (6 dominant and 5 non-dominant eyes) with abnormal binocular vision (mean age 22 years), and 11 control subjects (11 dominant and 11 non-dominant eyes) (mean age 21 years) were enrolled. Macular retinal thickness measurements were performed by optical coherence tomography, with total macular retinal (TMR) and ganglion cell complex (GCC) thicknesses measured in 3- and 6-mm regions in each quadrant. Measurement values were then used to determine quadrant ratios.
  
  
  RESULTS
  Compared to the dominant eyes of the controls, the superior/inferior (S/I) ratio of the TMR thickness and GCC thickness in the 3-mm region was significantly lower in the dominant eyes of the strabismus group (P < 0.05, each). The superior temporal/inferior temporal (ST/IT) ratio of the GCC thickness in the dominant eyes of the strabismus group was also significantly lower (P < 0.01).
  
  
  CONCLUSIONS
  Dominant eyes of the strabismus group with abnormal binocular vision development exhibited thinner superior temporal GCC thicknesses in the 3-mm region. Retinal ganglion cells in this region might be affected by efferent neural degeneration that originates in the visual pathway responsible for adaptations to the visual experience.
authors.affiliation: Department of Sensory Science, Orthoptist Course, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama, Japan. okamayu@mw.kawasaki-m.ac.jp
authors.forename: Mayumi
authors.initials: M
authors.lastname: Oka
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yamashita
authors.forename: Shizuka
authors.initials: S
authors.lastname: Ono
authors.forename: Ikumi
authors.initials: I
authors.lastname: Kubo
authors.forename: Akio
authors.initials: A
authors.lastname: Tabuchi
mesh_terms: D000293:Adolescent; D000328:Adult; D023882:Dominance, Ocular; D005260:Female; D006801:Humans; D008297:Male; D009929:Organ Size; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D013285:Strabismus / Q000150:complications*; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000150:complications*; D015348:Vision, Binocular; D014792:Visual Acuity; D055815:Young Adult