title: Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains.
abstract: Genome3D, available at http://www.genome3d.eu, is a new collaborative project that integrates UK-based structural resources to provide a unique perspective on sequence-structure-function relationships. Leading structure prediction resources (DomSerf, FUGUE, Gene3D, pDomTHREADER, Phyre and SUPERFAMILY) provide annotations for UniProt sequences to indicate the locations of structural domains (structural annotations) and their 3D structures (structural models). Structural annotations and 3D model predictions are currently available for three model genomes (Homo sapiens, E. coli and baker's yeast), and the project will extend to other genomes in the near future. As these resources exploit different strategies for predicting structures, the main aim of Genome3D is to enable comparisons between all the resources so that biologists can see where predictions agree and are therefore more trusted. Furthermore, as these methods differ in whether they build their predictions using CATH or SCOP, Genome3D also contains the first official mapping between these two databases. This has identified pairs of similar superfamilies from the two resources at various degrees of consensus (532 bronze pairs, 527 silver pairs and 370 gold pairs).
authors.affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, London, WC1E 6BT, UK.
authors.forename: Tony E
authors.initials: TE
authors.lastname: Lewis
authors.forename: Ian
authors.initials: I
authors.lastname: Sillitoe
authors.forename: Antonina
authors.initials: A
authors.lastname: Andreeva
authors.forename: Tom L
authors.initials: TL
authors.lastname: Blundell
authors.forename: Daniel W A
authors.initials: DW
authors.lastname: Buchan
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chothia
authors.forename: Alison
authors.initials: A
authors.lastname: Cuff
authors.forename: Jose M
authors.initials: JM
authors.lastname: Dana
authors.forename: Ioannis
authors.initials: I
authors.lastname: Filippis
authors.forename: Julian
authors.initials: J
authors.lastname: Gough
authors.forename: Sarah
authors.initials: S
authors.lastname: Hunter
authors.forename: David T
authors.initials: DT
authors.lastname: Jones
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Kelley
authors.forename: Gerard J
authors.initials: GJ
authors.lastname: Kleywegt
authors.forename: Federico
authors.initials: F
authors.lastname: Minneci
authors.forename: Alex
authors.initials: A
authors.lastname: Mitchell
authors.forename: Alexey G
authors.initials: AG
authors.lastname: Murzin
authors.forename: Bernardo
authors.initials: B
authors.lastname: Ochoa-Montaño
authors.forename: Owen J L
authors.initials: OJ
authors.lastname: Rackham
authors.forename: James
authors.initials: J
authors.lastname: Smith
authors.forename: Michael J E
authors.initials: MJ
authors.lastname: Sternberg
authors.forename: Sameer
authors.initials: S
authors.lastname: Velankar
authors.forename: Corin
authors.initials: C
authors.lastname: Yeats
authors.forename: Christine
authors.initials: C
authors.lastname: Orengo
mesh_terms: D030562:Databases, Protein; D023281:Genomics; D006801:Humans; D020407:Internet; D058977:Molecular Sequence Annotation; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics; D012984:Software
chemical_list: D011506:Proteins