title: Khayseneganins A-H, limonoids from Khaya senegalensis.
abstract: Eight new limonoids, khayseneganins A-H (1-8), and 31 known limonoids were isolated from the leaves and twigs of Khaya senegalensis. The structures of the new compounds were elucidated by 2D-NMR spectroscopy and mass spectrometry, and the absolute configuration of 1 was determined by the CD exciton chirality method. Compounds 9, 10, 12, and 15 showed antimicrobial activities against Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#), all with a MIC value of 12.5 μg/mL.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Chun-Mao
authors.initials: CM
authors.lastname: Yuan
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Cao
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Wang
authors.forename: Guo-Ying
authors.initials: GY
authors.lastname: Zuo
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: C580911:3-deacetylkhivorin; D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D036701:Limonins