title: RGO LBL modified biomimetic electrochemical sensor for detection of Sildenafil in herbal sexual health products.
abstract: In this work, a highly sensitive and selective biomimetic electrochemical sensor for Sildenafil in herbal sexual health products was prepared. Reduced graphene oxide (RGO), a novel highly conductive material was used to modify glassy carbon electrode (GCE) through layer-by-layer (LBL) self-assembly. The conductive molecularly imprinted films were constructed on the functional electrode surface using Sildenafil as template molecules, p-phenylenediamine (p-PD) as functional monomers. The obtained molecularly imprinted electrochemical sensor (MIES) was successfully used to detect Sildenafil in herbal sexual health products. The limit of detection (LOD) was 6.2 nmol L⁻¹. The recoveries for the spiked Sildenafil contents were in the range of 92.34-97.71% with the RSD < 2.31%. The selective efficiencies for Sildenafil and other structurally related analogues only slightly varied from 0.93 to 1.09.
authors.affiliation: School of Pharmacy, Nanjing Medical University, Nanjing 211100, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.forename: Tingting
authors.initials: T
authors.lastname: Wen
authors.forename: Cheng
authors.initials: C
authors.lastname: Xue
authors.forename: Qing
authors.initials: Q
authors.lastname: Han
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Junli
authors.initials: J
authors.lastname: Hong
authors.forename: Xuemin
authors.initials: X
authors.lastname: Zhou
authors.forename: Huijun
authors.initials: H
authors.lastname: Jiang
mesh_terms: D032701:Biomimetics; D015374:Biosensing Techniques / Q000379:methods*; D055664:Electrochemical Techniques; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D057230:Limit of Detection; D037742:Nanotubes, Carbon / Q000737:chemistry; D010655:Phenylenediamines / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011687:Purines / Q000737:chemistry; D060728:Reproductive Health; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D010655:Phenylenediamines; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D006046:Gold; D006108:Graphite; D000068677:Sildenafil Citrate