title: Diabetes and pancreatic cancer.
abstract: The relationship between diabetes and pancreatic cancer is complex. Diabetes or impaired glucose tolerance is present in more than 2/3rd of pancreatic cancer patients. Epidemiological studies have consistently shown a modest increase in the risk of pancreatic cancer in type 2 diabetes, with an inverse relationship to duration of disease. Additionally, recent studies suggest that anti-diabetic medications may modulate the risk of pancreatic cancer in type 2 diabetes. Subjects >50 years of age with new onset diabetes are at higher risk of having pancreatic cancer. However, to screen new-onset diabetes for pancreatic cancer, additional markers are needed that can distinguish pancreatic cancer-associated diabetes from type 2 diabetes.
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA.
authors.forename: T
authors.initials: T
authors.lastname: Muniraj
authors.forename: S T
authors.initials: ST
authors.lastname: Chari
mesh_terms: D000367:Age Factors; D015992:Body Mass Index; D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D055088:Early Detection of Cancer; D019317:Evidence-Based Medicine; D014943:Global Health; D018149:Glucose Intolerance / Q000150:complications / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications / Q000453:epidemiology / Q000209:etiology*; D007004:Hypoglycemic Agents / Q000009:adverse effects; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting / Q000009:adverse effects; D015201:Meta-Analysis as Topic; D008687:Metformin / Q000009:adverse effects; D009765:Obesity / Q000150:complications; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D007004:Hypoglycemic Agents; D049528:Insulin, Long-Acting; D000069036:Insulin Glargine; D008687:Metformin