title: Mitochondriogenesis genes and extreme longevity.
abstract: Genes of the proliferator-activated receptor delta (PPARD)-peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A, also termed PGC1-α)-nuclear respiratory factor (NRF)-mitochondrial transcription Factor A (TFAM) mitochondriogenesis pathway can influence health/disease phenotypes, yet their association with extreme longevity is not known. We studied the association of five common polymorphisms in genes of this pathway (rs2267668, rs8192678, rs6949152, rs12594956, rs1937) and extreme longevity using a case (107 centenarians)-control (284 young adults) design. We found no between-group differences in allele/genotype frequencies, except for CC genotype in rs1937 (p=0.003), with no representation in controls (0%), versus 2.8% in centenarians (2 men, 1 woman). In summary, the studied genetic variants of the PPARD-PPARGC1A-NRF-TFAM pathway were not associated with extreme longevity, yet a marginal association could exist for rs1937.
authors.affiliation: Universidad Europea de Madrid, Madrid, Spain.
authors.forename: Catalina
authors.initials: C
authors.lastname: Santiago
authors.forename: Nuria
authors.initials: N
authors.lastname: Garatachea
authors.forename: Thomas
authors.initials: T
authors.lastname: Yvert
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rodríguez-Romo
authors.forename: Alejandro
authors.initials: A
authors.lastname: Santos-Lozano
authors.forename: Carmen
authors.initials: C
authors.lastname: Fiuza-Luces
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008928:Mitochondria / Q000235:genetics*