title: The serum vaspin levels are reduced in Japanese chronic hemodialysis patients.
abstract: BACKGROUND
  Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified in genetically obese rats that correlates with insulin resistance and obesity in humans. Recently, we found that 7% of the Japanese population with the minor allele sequence (A) of rs77060950 exhibit higher levels of serum vaspin. We therefore evaluated the serum vaspin levels in Japanese chronic hemodialysis patients.
  
  
  METHODS
  Healthy Japanese control volunteers (control; n = 95, 49.9 ± 6.91 years) and Japanese patients undergoing hemodialysis therapy (HD; n = 138, 51.4 ± 10.5 years) were enrolled in this study, and serum samples were subjected to the human vaspin RIA system.
  
  
  RESULTS
  The measurement of the serum vaspin levels demonstrated that a fraction of control subjects (n = 5) and HD patients (n = 11) exhibited much higher levels (> 10 ng/ml; Vaspin High group), while the rest of the population exhibited lower levels (< 3 ng/ml; Vaspin Low group). By comparing the patients in the Vaspin Low group, the serum vaspin levels were found to be significantly higher in the control subjects (0.87 ± 0.24 ng/ml) than in the HD patients (0.32 ± 0.15 ng/ml) (p < 0.0001). In the stepwise regression analyses, the serum creatinine and triglyceride levels were found to be independently and significantly associated with the vaspin concentrations in all subjects.
  
  
  CONCLUSIONS
  The creatinine levels are negatively correlated with the serum vaspin levels and were significantly reduced in the Japanese HD patients in the Vaspin Low group.
authors.affiliation: Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Inoue
authors.forename: Jun
authors.initials: J
authors.lastname: Wada
authors.forename: Sanae
authors.initials: S
authors.lastname: Teshigawara
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hida
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakatsuka
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takatori
authors.forename: Shoichirou
authors.initials: S
authors.lastname: Kojo
authors.forename: Shigeru
authors.initials: S
authors.lastname: Akagi
authors.forename: Kazushi
authors.initials: K
authors.lastname: Nakao
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyatake
authors.forename: John F
authors.initials: JF
authors.lastname: McDonald
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Makino
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000037:antagonists & inhibitors / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000235:genetics / Q000628:therapy*; D015843:Serpins / Q000097:blood*
chemical_list: D015415:Biomarkers; C507339:SERPINA12 protein, human; D015843:Serpins; D003404:Creatinine