title: Gold-catalyzed domino cycloisomerization/Pictet-Spengler reaction of 2-(4-aminobut-1-yn-1-yl)anilines with aldehydes: synthesis of tetrahydropyrido[4,3-b]indole scaffolds.
abstract: A domino cycloisomerization/Pictet-Spengler reaction of 2-(4-aminobut-1-yn-1-yl)aniline with aldehydes has been achieved using a AuIPrCl (5 mol %)/AgSbF(6) (10 mol %) catalytic system to produce the corresponding 1-aryl-N-tosyl-2,3,4,5-tetrahydropyrido[4,3-b] indole derivatives in good yields. This is the first report on the synthesis of tetrahydro pyrido[4,3-b]indole scaffolds through as tandem 5-endo-dig cyclization and Pictect-Spengler reaction.
authors.affiliation: Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. basireddy@iict.res.in
authors.forename: B V
authors.initials: BV
authors.lastname: Subba Reddy
authors.forename: Manisha
authors.initials: M
authors.lastname: Swain
authors.forename: S Madhusudana
authors.initials: SM
authors.lastname: Reddy
authors.forename: J S
authors.initials: JS
authors.lastname: Yadav
authors.forename: B
authors.initials: B
authors.lastname: Sridhar
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007536:Isomerism
chemical_list: D000447:Aldehydes; D000814:Aniline Compounds; D007211:Indoles; D006046:Gold; C023650:aniline