title: Cannabinoid type 1 receptor gene polymorphism and macronutrient intake.
abstract: BACKGROUND
  Cannabinoid type 1 receptor (CB1-R) is a key mediator in the control of food intake and is linked to obesity.
  
  
  OBJECTIVE
  To evaluate the relationship between CB1-R gene polymorphism and dietary macronutrient intake in elderly subjects.
  
  
  METHODS
  This study included 118 subjects (60 males, 58 females) from a population survey carried out in southern Italy in 1992-1993 who were older than 65 years and previously characterized for CB1-R polymorphism (75 with GG wild-type genotype, 41 with heterozygous polymorphic allele AG, and 2 with genotype AA). All subjects completed a validated semi-quantitative food frequency questionnaire. Statistical methods included multiple logistic regression to model macronutrient intake to genotype, controlling for potential confounders.
  
  
  RESULTS
  When controlled for age, gender, and body mass index, the intake of dietary cholesterol and saturated fats corrected for calories was inversely associated with the CB1-R 1359 G/A polymorphism, while the intake of starchy carbohydrates was directly associated with this polymorphism.
  
  
  CONCLUSIONS
  In our unselected elderly population, the 1359 G/A polymorphism is linked with a specific macronutrient intake. This could be explained by the role of the cannabinoid system as a determinant of food intake and eating behavior.
authors.affiliation: Laboratory of Biochemistry, National Institute for Digestive Diseases, Saverio de Bellis, Castellana Grotte, Italy. gabriella.caruso@irccsdebellis.it
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Caruso
authors.forename: Patrizia
authors.initials: P
authors.lastname: Gazzerro
authors.forename: Maria
authors.initials: M
authors.lastname: Notarnicola
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Cisternino
authors.forename: Vito
authors.initials: V
authors.lastname: Guerra
authors.forename: Giovanni
authors.initials: G
authors.lastname: Misciagna
authors.forename: Chiara
authors.initials: C
authors.lastname: Laezza
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bifulco
mesh_terms: D000328:Adult; D000368:Aged; D004034:Diet Surveys; D004435:Eating / Q000235:genetics* / Q000502:physiology; D005260:Female; D005518:Food Preferences / Q000502:physiology; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D011795:Surveys and Questionnaires
chemical_list: D043884:Receptor, Cannabinoid, CB1