title: Contribution of the spinal microglia to bee venom-induced inflammatory pain in conscious rats.
abstract: It is well known that spinal glia plays a key role in the pathogenesis of pain. The present study was designed to determine the roles of spinal microglia in bee venom-induced persistent spontaneous nociception (PSN), mechanical hyperalgesia and inflammation. We determined the effects of microglia inhibitor minocycline on BV-induced PSN, mechanical hyperalgesia and inflammatory swelling. Pre-treatment with intrathecal administration of minocyline at different doses significantly inhibited BV-induced PSN and mechanical hyperalgesia, but had no effect on BV-induced inflammatory swelling. These data suggest that the activation of spinal microglia may play a key role in BV-induced nociception, but not inflammation.
authors.affiliation: Department of Neurology, General Hospital of Shen-Yang Military Region, Shen Yang 110840, PR China. chszh@yahoo.com.cn
authors.forename: Hui-Sheng
authors.initials: HS
authors.lastname: Chen
authors.forename: Jian-Xiu
authors.initials: JX
authors.lastname: Wang
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Zhang
authors.forename: Feng-Peng
authors.initials: FP
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Qu
authors.forename: Bao-Jun
authors.initials: BJ
authors.lastname: Liu
authors.forename: Man
authors.initials: M
authors.lastname: Li
authors.forename: Yao
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000818:Animals; D001514:Bee Venoms; D004487:Edema / Q000473:pathology; D006930:Hyperalgesia / Q000473:pathology / Q000503:physiopathology; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology; D007278:Injections, Spinal; D008297:Male; D017628:Microglia / Q000187:drug effects / Q000502:physiology*; D008911:Minocycline / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000473:pathology*; D014110:Touch
chemical_list: D001514:Bee Venoms; D008911:Minocycline