title: Cyclin A overexpression is associated with chemosensitivity to paclitaxel-based chemotherapy in patients with esophageal squamous cell carcinoma.
abstract: The aim of this study was to investigate the correlation between cyclin A expression and efficacy of paclitaxel-based chemotherapy in patients with esophageal squamous cell carcinoma (ESCC). The expression of cyclin A was examined in 48 newly diagnosed ESCC patients prior to treatment using the MaxVision immunohistochemistry method. The patients received four cycles of paclitaxel-based chemotherapy, the short-term treatment efficacy was evaluated and a 3-year follow-up was conducted. The response rate was greater in patients with positive cyclin A expression compared with those with negative expression (54.8 vs. 23.5%; χ(2)=4.373; P<0.05). Univariate and multivariate Cox analysis revealed that clinicopathological stage, degree of differentiation and expression of cyclin A were independent prognosis factors in patients with ESCC following paclitaxel-based chemotherapy. ESCC patients with positive cyclin A expression demonstrated an increased sensitivity to paclitaxel-based chemotherapy, suggesting that cyclin A may be used as a marker to predict the treatment efficacy of paclitaxel in patients with ESCC.
authors.affiliation: Departments of Oncology and.
authors.forename: Jun-Xing
authors.initials: JX
authors.lastname: Huang
authors.forename: Shuang-LE
authors.initials: SL
authors.lastname: Shen
authors.forename: Mei
authors.initials: M
authors.lastname: Lin
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.forename: Wei-Chang
authors.initials: WC
authors.lastname: Chen
authors.forename: Mao-Song
authors.initials: MS
authors.lastname: Lin
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Rong-Yu
authors.initials: RY
authors.lastname: Qian