title: Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer.
abstract: Genome-wide association studies (GWASs) of renal cell cancer (RCC) have identified four susceptibility loci thus far. To identify an additional RCC common susceptibility locus, we conducted a GWAS and performed a meta-analysis with published GWASs (totalling 2215 cases and 8566 controls of European background) and followed up the most significant association signals [nine single nucleotide polymorphisms (SNPs) in eight genomic regions] in 3739 cases and 8786 controls. A combined analysis identified a novel susceptibility locus mapping to 2q22.3 marked by rs12105918 (P = 1.80 × 10(-8); odds ratio 1.29, 95% CI: 1.18-1.41). The signal localizes to intron 2 of the ZEB2 gene (zinc finger E box-binding homeobox 2). Our findings suggest that genetic variation in ZEB2 influences the risk of RCC. This finding provides further insights into the genetic and biological basis of inherited genetic susceptibility to RCC.
authors.affiliation: Division of Genetics and Epidemiology, Section of Cancer Genetics, Institute of Cancer Research, Surrey SM2 5NG, UK.
authors.forename: Marc
authors.initials: M
authors.lastname: Henrion
authors.forename: Matthew
authors.initials: M
authors.lastname: Frampton
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Scelo
authors.forename: Mark
authors.initials: M
authors.lastname: Purdue
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Ye
authors.forename: Peter
authors.initials: P
authors.lastname: Broderick
authors.forename: Alastair
authors.initials: A
authors.lastname: Ritchie
authors.forename: Richard
authors.initials: R
authors.lastname: Kaplan
authors.forename: Angela
authors.initials: A
authors.lastname: Meade
authors.forename: James
authors.initials: J
authors.lastname: McKay
authors.forename: Mattias
authors.initials: M
authors.lastname: Johansson
authors.forename: Mark
authors.initials: M
authors.lastname: Lathrop
authors.forename: James
authors.initials: J
authors.lastname: Larkin
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Wang
authors.forename: Wong-Ho
authors.initials: WH
authors.lastname: Chow
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Stevens
authors.forename: W
authors.initials: W
authors.lastname: Ryan Diver
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gapstur
authors.forename: Demetrius
authors.initials: D
authors.lastname: Albanes
authors.forename: Jarmo
authors.initials: J
authors.lastname: Virtamo
authors.forename: Xifeng
authors.initials: X
authors.lastname: Wu
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Stephen
authors.initials: S
authors.lastname: Chanock
authors.forename: Timothy
authors.initials: T
authors.lastname: Eisen
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012097:Repressor Proteins / Q000235:genetics*; D012307:Risk Factors; D000074165:Zinc Finger E-box Binding Homeobox 2
chemical_list: D018398:Homeodomain Proteins; D012097:Repressor Proteins; C492363:ZEB2 protein, human; D000074165:Zinc Finger E-box Binding Homeobox 2