title: In vivo vascular wall shear rate and circumferential strain of renal disease patients.
abstract: This study measures the vascular wall shear rate at the vessel edge using decorrelation based ultrasound speckle tracking. Results for nine healthy and eight renal disease subjects are presented. Additionally, the vascular wall shear rate and circumferential strain during physiologic pressure, pressure equalization and hyperemia are compared for five healthy and three renal disease subjects. The mean and maximum wall shear rates were measured during the cardiac cycle at the top and bottom wall edges. The healthy subjects had significantly higher mean and maximum vascular wall shear rate than the renal disease subjects. The key findings of this research were that the mean vascular wall shear rates and circumferential strain changes between physiologic pressure and hyperemia that was significantly different between healthy and renal disease subjects.
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA. bigrain@umich.edu
authors.forename: Dae Woo
authors.initials: DW
authors.lastname: Park
authors.forename: Grant H
authors.initials: GH
authors.lastname: Kruger
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Rubin
authors.forename: James
authors.initials: J
authors.lastname: Hamilton
authors.forename: Paul
authors.initials: P
authors.lastname: Gottschalk
authors.forename: Robert E
authors.initials: RE
authors.lastname: Dodde
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Shih
authors.forename: William F
authors.initials: WF
authors.lastname: Weitzel
mesh_terms: D000328:Adult; D000368:Aged; D001916:Brachial Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D033081:Shear Strength; D013314:Stress, Mechanical; D059289:Vascular Stiffness