title: Perhydrolase-nanotube paint composites with sporicidal and antiviral activity.
abstract: AcT (perhydrolase) containing paint composites were prepared leading to broad-spectrum decontamination. AcT was immobilized onto multi-walled carbon nanotubes (MWNTs) and then incorporated into latex-based paints to form catalytic coatings. These AcT-based paint composites showed a 6-log reduction in the viability of spores of Bacillus cereus and Bacillus anthracis (Sterne) within 60 min. The paint composites also showed >4-log reduction in the titer of influenza virus (X-31) within 10 min (initially challenged with 10(7) PFU/mL). AcT-based paint composites were also tested using various perhydrolase acyl donor substrates, including propylene glycol diacetate (PGD), glyceryl triacetate, and ethyl acetate, with PGD observed to be the best among the substrates tested for generation of peracetic acid and killing of bacillus spores. The operational stability of paint composites was also studied at different relative humidities and temperatures to simulate real-life operation.
authors.affiliation: Department of Chemical and Biological Engineering, Rensselaer Nanotechnology Center, and Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
authors.forename: Navdeep
authors.initials: N
authors.lastname: Grover
authors.forename: Marc P
authors.initials: MP
authors.lastname: Douaisi
authors.forename: Indrakant V
authors.initials: IV
authors.lastname: Borkar
authors.forename: Lillian
authors.initials: L
authors.lastname: Lee
authors.forename: Cerasela Zoica
authors.initials: CZ
authors.lastname: Dinu
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Kane
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Dordick
mesh_terms: D000890:Anti-Infective Agents / Q000378:metabolism*; D000998:Antiviral Agents / Q000378:metabolism*; D001408:Bacillus anthracis / Q000187:drug effects / Q000502:physiology; D001409:Bacillus cereus / Q000187:drug effects / Q000502:physiology; D004800:Enzymes, Immobilized / Q000378:metabolism*; D006867:Hydrolases / Q000378:metabolism*; D050296:Microbial Viability / Q000187:drug effects*; D043942:Nanotubes; D009975:Orthomyxoviridae / Q000187:drug effects; D010150:Paint; D010463:Peracetic Acid / Q000378:metabolism; D013171:Spores, Bacterial / Q000187:drug effects / Q000502:physiology
chemical_list: D000890:Anti-Infective Agents; D000998:Antiviral Agents; D004800:Enzymes, Immobilized; D006867:Hydrolases; D010463:Peracetic Acid