title: Motility disorders of the colon and rectum.
abstract: OBJECTIVE
  Symptoms associated with disorders of the motility of colon and rectum are common problems in clinical practice. Advances in this field continue to expand our understanding of these disorders and provide new and different treatments with promising results.
  
  
  RESULTS
  This article reviews new advances in the past year on the measurement and diagnosis of colonic transit. Recently published data question the importance of dietary fiber in the prevention of colonic diverticulosis and diverticulitis, and support the efficacy of a number of different therapies aimed at improving colonic motility and visceral sensation in constipation and reversing the effects of opioid induced constipation with peripherally acting opioid antagonists.
  
  
  CONCLUSIONS
  The articles referenced in this review help inform the reader on new developments in the diagnosis and management of patients with colonic and rectal motility disorders.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Gras
authors.forename: Suma
authors.initials: S
authors.lastname: Magge
authors.forename: Andrea
authors.initials: A
authors.lastname: Bloom
authors.forename: Anthony
authors.initials: A
authors.lastname: Lembo
mesh_terms: D003248:Constipation / Q000175:diagnosis* / Q000188:drug therapy*; D004032:Diet / Q000009:adverse effects*; D004151:Dipeptides / Q000627:therapeutic use; D043963:Diverticulosis, Colonic / Q000209:etiology*; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005772:Gastrointestinal Transit; D006801:Humans; D009271:Naltrexone / Q000031:analogs & derivatives / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D010455:Peptides / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use; D012002:Rectal Diseases / Q000175:diagnosis / Q000188:drug therapy; D013841:Thiazepines / Q000627:therapeutic use; D014365:Tryptophan Hydroxylase / Q000037:antagonists & inhibitors
chemical_list: D004151:Dipeptides; D005765:Gastrointestinal Agents; D009292:Narcotic Antagonists; D010455:Peptides; D010880:Piperidines; D000644:Quaternary Ammonium Compounds; D013841:Thiazepines; C032257:methylnaltrexone; D009271:Naltrexone; C419502:alvimopan; C581303:elobixibat; D014365:Tryptophan Hydroxylase; C523483:linaclotide