title: Time to diagnosis of paediatric posterior fossa tumours: an 11-year West of Scotland experience 2000-2011.
abstract: BACKGROUND
  Brain tumours are the most common solid childhood malignancy accounting for 20% of all paediatric cancers. Of these, posterior fossa tumours comprise approximately 60-70% of all brain tumours in children. Several studies have estimated the median pre-diagnostic interval (PSI) of paediatric brain tumours as approximately 60 days.
  
  
  OBJECTIVE
  The objectives of this retrospective analysis were to (a) identify the common presenting symptoms of posterior fossa tumours, (b) determine the time interval from the first attributable symptom to the radiological diagnosis of a posterior fossa tumour, (c) compare the West of Scotland with other international centres and (d) identify which factors correlate with outcome for these children.
  
  
  METHODS
  A retrospective case note review of 69 children diagnosed with posterior fossa tumours from January 2000 to September 2011. Of the 69 children diagnosed during this period, complete data were available for 66 children (M:F = 31:35, Mean age (SD): 7.50 + 4.53 years). Results. Nausea and vomiting (75.8%), headaches (63.6%) and incoordination (51.5%) were recorded as the most common presenting symptoms followed by lethargy (28.8%), cranial nerve palsy (25.8%) and diplopia (24.2%). Fifty-three of the sixty-six children (i.e., 80.3%) demonstrated radiological evidence of hydrocephalus on their initial scan. The majority of children were assessed by less than three specialists after a median PSI of 43.5 days. The only variable significantly associated with PSI was tumour grade (r = - 0.202, p = 0.036). Neither age at diagnosis, number of specialists seen, nor outcome was significantly correlated with PSI. The only factor associated with outcome was tumour grade (r = 0.337, p = 0.006).
  
  
  CONCLUSIONS
  Despite recent reports indicating poor performance of the UK with respect to time to diagnosis of paediatric brain tumours, the present data indicate that the experience of this cohort is favourably comparable to international standards.
authors.affiliation: Institute for Neurological Sciences, Department of Neurosurgery, Southern General Hospital, Glasgow, Scotland, UK. michellekamedasmith@gmail.com
authors.forename: M M
authors.initials: MM
authors.lastname: Kameda-Smith
authors.forename: M A J
authors.initials: MA
authors.lastname: White
authors.forename: E J
authors.initials: EJ
authors.lastname: St George
authors.forename: J I M
authors.initials: JI
authors.lastname: Brown
mesh_terms: D017677:Age Distribution; D002648:Child; D057210:Delayed Diagnosis / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015192:Infratentorial Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D009460:Neurologic Examination / Q000706:statistics & numerical data; D011379:Prognosis; D011859:Radiography; D012017:Referral and Consultation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012606:Scotland