title: Diet and blood lipids in 1-4 year-old children.
abstract: OBJECTIVE
  Early nutrition may programme blood lipid levels and thereby later cardiovascular health of children. The objective here was to evaluate the effects of maternal dietary counselling during pregnancy and breastfeeding on dietary intakes and blood lipid values in 1-4 year-old children. Further, the nutritional determinants of children's lipid profiles were assessed.
  
  
  RESULTS
  Mothers were randomised into dietary counselling or control groups at the first trimester of pregnancy. Their children were followed up clinically at 1, 2 and 4 years of age, by three-day food records and analyses of total cholesterol, HDL cholesterol and apolipoproteins A-I and B as well as lipoprotein (a). In general, the mean intake of saturated fatty acids as a proportion of total energy intake (E%) was higher than the recommended, while the mean intake of polyunsaturated fatty acids was low in children's diet. Over the first years, girls had higher concentration of non-HDL cholesterol than boys; 2.64 mmol/l (95% CI 2.54-2.74) vs. 2.49 (2.38-2.60); p = 0.038. Maternal dietary counselling was not reflected in the children's lipid values. Children's monounsaturated fatty acid intake (E%) correlated with apoA-I (p = 0.048) and, furthermore, there was a negative correlation between polyunsaturated fatty acid intake (E%) and apoB (p = 0.046).
  
  
  CONCLUSIONS
  Children's dietary fatty acid intake, but not maternal dietary counselling was shown to be related to blood apolipoproteins in children.
authors.affiliation: Functional Foods Forum, 20014 University of Turku, Turku, Finland. Electronic address: ullhop@utu.fi.
authors.forename: U
authors.initials: U
authors.lastname: Hoppu
authors.forename: E
authors.initials: E
authors.lastname: Isolauri
authors.forename: P
authors.initials: P
authors.lastname: Koskinen
authors.forename: K
authors.initials: K
authors.lastname: Laitinen
mesh_terms: D001942:Breast Feeding; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D002657:Child Development; D002664:Child Nutritional Physiological Phenomena; D002675:Child, Preschool; D015331:Cohort Studies; D004041:Dietary Fats / Q000008:administration & dosage* / Q000009:adverse effects; D005247:Feeding Behavior; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D009035:Mothers / Q000193:education; D052756:Nutritional Sciences / Q000193:education; D010353:Patient Education as Topic; D011247:Pregnancy; D012307:Risk Factors; D012727:Sex Characteristics
chemical_list: D004041:Dietary Fats; D008074:Lipoproteins