title: Reduction in the leptin concentration as a predictor of improvement in lung function in obese adolescents.
abstract: OBJECTIVE
  To assess the effects of weight loss on adipokines, asthma-related symptoms, exercise-induced bronchospasm (EIB) and lung function, and to evaluate the role of leptin and adiponectin levels on lung function after treatment in obese adolescents.
  
  
  METHODS
  84 postpubertal obese adolescents were enrolled and distributed in quartiles according to weight loss (low (<2.5 kg), low to moderate (>2.5 and <8 kg), moderate (<8 and <14 kg) and massive (<14 kg)). Body composition was measured by plethysmography, and visceral and subcutaneous fat were detected by ultrasound. Serum levels of adiponectin and leptin were analyzed. Lung function, asthma and EIB were evaluated according to the American Thoracic Society criteria. Patients were submitted to 1 year of interdisciplinary intervention consisting of physiotherapy, medical, nutritional, exercise, and psychological therapy.
  
  
  RESULTS
  After treatment the moderate and massive weight loss promoted an increase in adiponectin and adiponectin/leptin (A/L) ratio as well as a decrease in leptin levels and a reduction in EIB frequency and asthma-related symptoms. Furthermore, the reduction in leptin levels was a predictor factor to improvement in lung function.
  
  
  CONCLUSIONS
  Interdisciplinary therapy was able to decrease EIB and asthma-related symptoms and to improve pro/anti-inflammatory adipokines. Additionally, the leptin concentration was a predictor factor to explain changes in lung function.
authors.affiliation: Post Graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Leão da Silva
authors.forename: Marco Túlio
authors.initials: MT
authors.lastname: de Mello
authors.forename: Nadia Carla
authors.initials: NC
authors.lastname: Cheik
authors.forename: Priscila Lima
authors.initials: PL
authors.lastname: Sanches
authors.forename: Raquel
authors.initials: R
authors.lastname: Munhoz da Silveira Campos
authors.forename: June
authors.initials: J
authors.lastname: Carnier
authors.forename: Daniela
authors.initials: D
authors.lastname: Inoue
authors.forename: Claudia M O
authors.initials: CM
authors.lastname: do Nascimento
authors.forename: Lila M
authors.initials: LM
authors.lastname: Oyama
authors.forename: Lian
authors.initials: L
authors.lastname: Tock
authors.forename: Sérgio
authors.initials: S
authors.lastname: Tufik
authors.forename: Ana R
authors.initials: AR
authors.lastname: Dâmaso
mesh_terms: D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D001249:Asthma / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D001250:Asthma, Exercise-Induced / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D004032:Diet; D015444:Exercise; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D026741:Physical Therapy Modalities; D011613:Psychotherapy; D015431:Weight Loss; D061217:Weight Reduction Programs
chemical_list: D052242:Adiponectin; D020738:Leptin