title: In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil).
abstract: Ethnomedicinal informations point to some Aspidosperma species (Apocynaceae) as antimalarial plants in Brazil and have motivated the evaluation of six species which were collected in the state of Minas Gerais: A. cylindrocarpon Müll. Arg., A. parvifolium A. DC., A. olivaceum Müll. Arg., A. ramiflorum Müll. Arg., A. spruceanum Benth. ex Müll. Arg. and A. tomentosum Mart.. A total of 23 extracts of different plant parts in different solvents were assayed in vitro against chloroquine-resistant (W2) and chloroquine-sensitive (3D7) strains of Plasmodium falciparum. All the extracts were shown to be active with IC50 values in the range of 5.0 ± 0 2.8 µg/mL to 65.0 ± 4.2 µg/mL. TLC profile of the extracts revealed the presence of alkaloids in the six species assayed. These results seem to confirm the popular use of Aspidosperma species to treat human malaria in Brazil and seem point to alkaloids as the putative active compounds of the assayed species.
authors.affiliation: Faculdade de Farmácia, ICS, Universidade Federal do Pará, Belém, PA, Brasil.
authors.forename: Maria Fâni
authors.initials: MF
authors.lastname: Dolabela
authors.forename: Salma G
authors.initials: SG
authors.lastname: Oliveira
authors.forename: José M
authors.initials: JM
authors.lastname: Peres
authors.forename: José M S
authors.initials: JM
authors.lastname: Nascimento
authors.forename: Marinete M
authors.initials: MM
authors.lastname: Póvoa
authors.forename: Alaide B
authors.initials: AB
authors.lastname: Oliveira
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D030009:Aspidosperma / Q000737:chemistry* / Q000145:classification; D006801:Humans; D020128:Inhibitory Concentration 50; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D010936:Plant Extracts