title: Whey protein hydrolysate enhances the exercise-induced heat shock protein (HSP70) response in rats.
abstract: Whey protein has been suggested to be potential protective agent against various forms of stress. The heat shock protein HSP70 confers greater cellular tolerance against stressors. The present study evaluated the effects of whey protein intake on HSP70 expression. Forty-eight male Wistar rats were divided into sedentary and exercised groups, and each group was fed as a protein source casein (CAS), whey protein (WP) or whey protein hydrolysate (WPH) for 3weeks. Exercise on a treadmill was used as the source of stress in the animals from the exercised group. The results showed a larger increase in HSP70 expression in the soleus, gastrocnemius and lung of the WPH-fed rats than WP or casein-fed rats. HSP70 expression in the sedentary rats was very low, independent of the diet or tissue. Protein carbonyls were lower in the group that consumed WPH. These data suggest that the consumption of WPH enhances HSP70 expression.
authors.affiliation: Department of Food and Nutrition, Faculty of Food Engineering, University of Campinas, Campinas, São Paulo, Brazil. linanutricao@yahoo.com.br
authors.forename: Carolina Soares
authors.initials: CS
authors.lastname: de Moura
authors.forename: Pablo Christiano Barboza
authors.initials: PC
authors.lastname: Lollo
authors.forename: Priscila Neder
authors.initials: PN
authors.lastname: Morato
authors.forename: Everardo Magalhães
authors.initials: EM
authors.lastname: Carneiro
authors.forename: Jaime
authors.initials: J
authors.lastname: Amaya-Farfan
mesh_terms: D000818:Animals; D015444:Exercise / Q000502:physiology*; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008894:Milk Proteins / Q000737:chemistry / Q000494:pharmacology*; D011492:Protein Hydrolysates / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D015854:Up-Regulation / Q000187:drug effects; D000067816:Whey Proteins
chemical_list: D018840:HSP70 Heat-Shock Proteins; D008894:Milk Proteins; D011492:Protein Hydrolysates; D000067816:Whey Proteins