title: Identical human papillomavirus (HPV) genomic variants persist in recurrent respiratory papillomatosis for up to 22 years.
abstract: Seventy initial and 125 follow-up tissue specimens of laryngeal papillomas, obtained from 70 patients who had had recurrent respiratory papillomatosis for from 1-22 years, were investigated for the presence of human papillomavirus (HPV) DNA and HPV E5a, LCR and/or full-length genomic variants. HPV-6 was found in 130/195, HPV-11 in 63/195, and HPV-6/HPV-11 in 2/195 samples. Within 67/70 (95.7%) patients, all follow-up HPV isolates genetically matched completely initial HPV isolate over the highly variable parts of the genome or over the entire genome. Frequent recurrence of laryngeal papillomas is a consequence of long-term persistence of the identical initial HPV genomic variant.
authors.affiliation: Institute of Microbiology and Immunology, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Boštjan J
authors.initials: BJ
authors.lastname: Kocjan
authors.forename: Nina
authors.initials: N
authors.lastname: Gale
authors.forename: Irena
authors.initials: I
authors.lastname: Hočevar Boltežar
authors.forename: Katja
authors.initials: K
authors.lastname: Seme
authors.forename: Kristina
authors.initials: K
authors.lastname: Fujs Komloš
authors.forename: Lea
authors.initials: L
authors.lastname: Hošnjak
authors.forename: Polona J
authors.initials: PJ
authors.lastname: Maver
authors.forename: Mateja M
authors.initials: MM
authors.lastname: Jelen
authors.forename: Irena
authors.initials: I
authors.lastname: Zupanič Pajnič
authors.forename: Jože
authors.initials: J
authors.lastname: Balažic
authors.forename: Mario
authors.initials: M
authors.lastname: Poljak
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D016679:Genome, Viral; D023281:Genomics; D005838:Genotype; D052140:Human papillomavirus 11 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D052163:Human papillomavirus 6 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007822:Laryngeal Neoplasms / Q000821:virology*; D008297:Male; D010212:Papilloma / Q000821:virology*; D030361:Papillomavirus Infections / Q000821:virology*; D012141:Respiratory Tract Infections / Q000821:virology*; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral