title: Kindlin-2 promotes genome instability in breast cancer cells.
abstract: Kindlin-2, as a focal adhesion protein, has been found to regulate tumor progression. However, the mechanism underlying Kindlin-2 regulation of tumor progression is largely unknown. Here, we report that Kindlin-2 regulates breast cancer cell proliferation, apoptosis and chromosomal abnormalities in both gain and loss of function assays. Functionally, overexpression of Kindlin-2 promotes tumor formation in implanted xenograft while knockdown of Kindlin-2 inhibits tumor growth in mice. Mechanistically, an array-based comparative genomic hybridization and karyotype analyses indicate that ectopic expression of Kindlin-2 leads to genome instability in breast cancer cells. Our data suggest a novel mechanism that Kindlin-2 regulates breast cancer progression by inducing genome instability.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Health Science Center, Beijing, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.forename: Lizhao
authors.initials: L
authors.lastname: Guan
authors.forename: Yu
authors.initials: Y
authors.lastname: Yu
authors.forename: Xuelian
authors.initials: X
authors.lastname: Pei
authors.forename: Jun
authors.initials: J
authors.lastname: Zhan
authors.forename: Ling
authors.initials: L
authors.lastname: Han
authors.forename: Yan
authors.initials: Y
authors.lastname: Tang
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Weigang
authors.initials: W
authors.lastname: Fang
authors.forename: Hongquan
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005260:Female; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis / Q000502:physiology*; D051379:Mice; D009363:Neoplasm Proteins / Q000032:analysis / Q000502:physiology*
chemical_list: C477322:FERMT3 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins