title: Antibody-mediated catalysis: induction and therapeutic relevance.
abstract: Abzymes are immunoglobulins endowed with enzymatic activities. The catalytic activity of an abzyme resides in the variable domain of the antibody, which is constituted by the close spatial arrangement of amino acid residues involved in catalysis. The origin of abzymes is conferred by the innate diversity of the immunoglobulin gene repertoire. Under deregulated immune conditions, as in autoimmune diseases, the generation of abzymes to self-antigens could be deleterious. Technical advancement in the ability to generate monoclonal antibodies has been exploited in the generation of abzymes with defined specificities and activities. Therapeutic applications of abzymes are being investigated with the generation of monoclonal abzymes against several pathogenesis-associated antigens. Here, we review the different contexts in which abzymes are generated, and we discuss the relevance of monoclonal abzymes for the treatment of human diseases.
authors.affiliation: Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, UMR S 872, Paris, France.
authors.forename: Ankit
authors.initials: A
authors.lastname: Mahendra
authors.forename: Meenu
authors.initials: M
authors.lastname: Sharma
authors.forename: Desirazu N
authors.initials: DN
authors.lastname: Rao
authors.forename: Ivan
authors.initials: I
authors.lastname: Peyron
authors.forename: Cyril
authors.initials: C
authors.lastname: Planchais
authors.forename: Jordan D
authors.initials: JD
authors.lastname: Dimitrov
authors.forename: Srini V
authors.initials: SV
authors.lastname: Kaveri
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lacroix-Desmazes
mesh_terms: D000818:Animals; D017151:Antibodies, Catalytic / Q000096:biosynthesis / Q000276:immunology / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002384:Catalysis; D006801:Humans; D007114:Immunization
chemical_list: D017151:Antibodies, Catalytic; D000911:Antibodies, Monoclonal