title: Relaxation response of abdominal aorta to androgens in orchidectomised Sprague-Dawley rats fed a high-salt diet.
abstract: Previous studies have demonstrated the acute relaxant effects of androgens on normal arterial beds, but not on any with underlying or induced pathologies. This study investigated whether the status of the gonads affects the direct actions of androgens on isolated abdominal aorta from male Sprague-Dawley rats fed a high-salt diet. A high-salt diet reduced the relaxation response to exogenous testosterone, but not to dehydroepiandrosterone (DHEA). Orchidectomy reduced the relaxation response to both testosterone and DHEA, while testosterone replacement restored the acute vasorelaxant effect of testosterone and DHEA in both normal and high-salt diet fed rats. Gonadal status appears to be important in the acute vasorelaxant effect of androgens.
authors.affiliation: Department of Physiology, College of Medicine, University of Lagos, Idi-Araba Lagos, Nigeria. akoloyo@cmul.edu.ng
authors.forename: Ahmed Kolade
authors.initials: AK
authors.lastname: Oloyo
authors.forename: Renuka R
authors.initials: RR
authors.lastname: Nair
authors.forename: Chikodi N
authors.initials: CN
authors.lastname: Anigbogu
authors.forename: Olusoga A
authors.initials: OA
authors.lastname: Sofola
mesh_terms: D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects*; D003687:Dehydroepiandrosterone / Q000494:pharmacology; D004032:Diet; D008297:Male; D009919:Orchiectomy / Q000379:methods; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*; D013739:Testosterone / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000728:Androgens; D017673:Sodium Chloride, Dietary; D014665:Vasodilator Agents; D013739:Testosterone; D003687:Dehydroepiandrosterone