title: Hepatoprotective effects of Panax notoginseng: Ginsenosides -Re and -Rg(1) as its active constituents in D-galactosamine/lipopolysaccharide-induced liver injury.
abstract: The hepatoprotective effects of the methanol and water extracts of the roots of Panax notoginseng were studied on various animal models. The methanol and water extracts of P. notoginseng showed a significant activity in carbon tetrachloride-induced liver injury in rats. However, the methanol extract was found to be more active. The hepatoprotective effects of the methanol extract was further evaluated using D-galactosamine as well as heat-killed Propionibacterium acnes/lipopolysaccharide-induced liver injury models. Two major isolates from the methanol extract, ginsenosides-Re and -Rgl, showed a significant hepatoprotective effect on D-galactos-amine/lipopolysaccharide-induced liver injury in mice.
authors.affiliation: Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01 Japan.
authors.forename: J K
authors.initials: JK
authors.lastname: Prasain
authors.forename: S
authors.initials: S
authors.lastname: Kadota
authors.forename: P
authors.initials: P
authors.lastname: Basnet
authors.forename: K
authors.initials: K
authors.lastname: Hase
authors.forename: T
authors.initials: T
authors.lastname: Namba