title: [Ischemic cholangitis in intensive care unit: favourable outcome with ursodesoxycholic acid and fenofibrate].
abstract: BACKGROUND
  Ischemic cholangitis in intensive care unit is a recently reported liver disease in patients who have had a prolonged mechanical ventilation and vasopressive drug support for multiple organ deficiency. Prognosis is usually poor and the only life-saving therapy is liver transplantation despite ursodesoxycholic acid treatment.
  
  
  METHODS
  We report a 63-year-old man who presented with a sclerosis cholangitis after a month in intensive care unit, effectively treated with fenofibrate and ursodesoxycholic acid. Recent reports underline fenofibrate efficacy in the treatment of primary biliary cirrhosis, especially in association with ursodesoxycholic acid. This treatment has prevented liver transplantation for our patient with a correct quality of life.
  
  
  CONCLUSIONS
  The addition of fibrate to ursodesoxycholic acid improves persistent cholestasis in sclerosing cholangitis.
authors.affiliation: Service de médecine interne, hôpital de la Timone, Marseille, France. pauline.belenotti@ap-hm.fr
authors.forename: P
authors.initials: P
authors.lastname: Bélénotti
authors.forename: C
authors.initials: C
authors.lastname: Guervilly
authors.forename: P
authors.initials: P
authors.lastname: Grandval
authors.forename: A
authors.initials: A
authors.lastname: Benyamine
authors.forename: N
authors.initials: N
authors.lastname: Ene
authors.forename: J
authors.initials: J
authors.lastname: Serratrice
authors.forename: P
authors.initials: P
authors.lastname: Petit
authors.forename: R
authors.initials: R
authors.lastname: Laugier
authors.forename: L
authors.initials: L
authors.lastname: Papazian
authors.forename: P-J
authors.initials: PJ
authors.lastname: Weiller
mesh_terms: D002756:Cholagogues and Choleretics / Q000008:administration & dosage / Q000627:therapeutic use; D015209:Cholangitis, Sclerosing / Q000188:drug therapy* / Q000209:etiology*; D003422:Critical Care; D011345:Fenofibrate / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D002756:Cholagogues and Choleretics; D000960:Hypolipidemic Agents; D014580:Ursodeoxycholic Acid; D011345:Fenofibrate