title: Comparing S-100 beta protein levels and neurocognitive functions between patients undergoing on-pump and off-pump coronary artery bypass grafting.
abstract: BACKGROUND
  In the present study, we aimed to investigate the effects of off-pump coronary artery bypass grafting and on-pump cardiopulmonary bypass on the serum S-100 beta (S-100B) protein levels and neurocognitive functions of the patients.
  
  
  METHODS
  Sixty-four patients undergoing coronary artery bypass grafting (CABG) were enrolled in the study and were divided into two groups: off-pump (group I, n = 24) and on-pump CABG (group II, n = 40) group. Serum S-100B levels were measured before and 0, 6, and 24 h after the operation. Neurocognitive function tests were done preoperatively and were repeated in the postoperative period as well.
  
  
  RESULTS
  Serum S-100B levels were similar between the two groups preoperatively. However, median S-100B levels at 0, 6, and 24 h after the surgery were found to be significantly lower in the off-pump CABG group than in the on-pump group. The preoperative neurocognitive functions of the patients were similar between the two groups, whereas neurocognitive function was found to be significantly impaired postoperatively in the on-pump group in comparison with the off-pump CABG group.
  
  
  CONCLUSIONS
  We concluded that off-pump CABG is associated with decreased serum S100 protein levels and less impairment on neurocognitive functions compared with the on-pump group.
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey. drhuseyinbayram@gmail.com
authors.forename: Huseyin
authors.initials: H
authors.lastname: Bayram
authors.forename: Mete
authors.initials: M
authors.lastname: Hidiroglu
authors.forename: Levent
authors.initials: L
authors.lastname: Cetin
authors.forename: Aslihan
authors.initials: A
authors.lastname: Kucuker
authors.forename: Erkan
authors.initials: E
authors.lastname: Iriz
authors.forename: Emrah
authors.initials: E
authors.lastname: Uguz
authors.forename: Fethi
authors.initials: F
authors.lastname: Saglam
authors.forename: Erol
authors.initials: E
authors.lastname: Sener
mesh_terms: D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass; D003071:Cognition; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins