title: [Multiple viral transmission chains of enterovirus 71 co-circulated in Jilin Province during 2009-2010].
abstract: OBJECTIVE
  To analyze the genetic characterization of enterovirus type71 (EV71) associated with hand foot and mouth disease (HFMD) epidemics in Jilin province, during 2009-2010.
  
  
  METHODS
  Randomly selected 31 representative EV71 strains from the cases of 8 prefectures to amplify and sequences of VP1 genes of EV71 strains, and analyzed with Bioedit and Mega4.0 program.
  
  
  RESULTS
  All representative 31 EV71 strains belong to C4a subgenotype, the homology of nucleotide in VP1 region among the 31 EV71 strains were 94. 5%-100. 0%, and were clustered into 5 transmission chains respectively. 25 strains out of 31 strains were associated with a predominant transmission chain, and circulating in 8 prefectures, while other 6 strains clustered into 4 lineages.
  
  
  CONCLUSIONS
  Multiple transmission chains of EV71 C4a subgenotype were co-circulating in Jilin province during 2009-2010, and a predominant transmission chain was circulating in 8 prefectures, associated with HFMD outbreaks of Jilin province.
authors.affiliation: Jilin Provincial Center for Disease Control and Prevention, Key Virus Laboratory of Health Bureau of Jilin Province, Changchun 130062, China. zhoujianhui67@yahoo.com.cn
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Zhou
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Lei-Lei
authors.initials: LL
authors.lastname: Wei
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Zhong
authors.initials: Z
authors.lastname: Qi
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Gou
authors.forename: Chuang
authors.initials: C
authors.lastname: Chen
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Tan
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Xu
mesh_terms: D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D030016:Enterovirus D, Human / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D005243:Feces / Q000821:virology; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny