title: Stem cell-based treatments for spinal cord injury.
abstract: Cell replacement strategies hold great promise for the treatment of central nervous system injuries and degenerative diseases. The advancement of stem cell therapies has proven to be a viable therapeutic approach to limit secondary degeneration and restore neuronal circuitry at the site of injury. Cell replacement strategies confer phenotype-specific and neurotrophic benefits to the surrounding tissue; however, the mechanisms of transplant-mediated repair are unique to each transplant population. Here, we review stem cell-based therapies for spinal cord injury and disease, involving a number of stem cell derivates. We discuss the mechanisms by which each of these populations exert their affects and briefly discuss phenotype-specific cell replacement in these models.
authors.affiliation: Reeve-Irvine Research Center, University of California at Irvine, Irvine, CA, USA.
authors.forename: Lindsey A
authors.initials: LA
authors.lastname: Wyatt
authors.forename: Hans S
authors.initials: HS
authors.lastname: Keirstead
mesh_terms: D000818:Animals; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000601:surgery*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology*