title: Effect of recombinant human thyrotropin on the uptake of radioactive iodine (¹²³I) in dogs with thyroid tumors.
abstract: In humans, recombinant human thyrotropin (rhTSH) enhances radioactive iodine uptake (RAIU) in patients with differentiated thyroid cancer. No studies have been performed in veterinary medicine to optimize radioiodine treatment of thyroid cancer. The aim of this study was to evaluate the effect of rhTSH on the uptake of radioiodine-123 ((123)I) in dogs with thyroid tumors. Nine dogs with thyroid neoplasia were included in this prospective cross-over study. The dogs were divided in 2 groups. In one group, (123)I was administered for a baseline RAIU determination in week 1. In week 2 (after a washout period of 2 weeks), these dogs received rhTSH (100 μg IV) 24 h before (123)I injection. In the other group the order of the protocol was reversed. For each scan, the dogs received 37 MBq (1 mCi) of (123)I intravenously (IV) and planar scintigraphy was performed after 8 and 24 h for tumor RAIU calculation. Overall, rhTSH administration caused no statistically significant change on thyroid tumor RAIU at 8 h (p = 0.89) or at 24 h (p = 0.98). A significant positive correlation was found between the effect of rhTSH on tumor 8h-RAIU and rhTSH serum concentrations at 6 h (τ = 0.68; p = 0.03), at 12 h (τ = 0.68; p = 0.03) and at 24 h (τ = 0.78; p = 0.02) after rhTSH injection. This study suggests that IV administration of 100 μg rhTSH 24 h before (123)I has an inconsistent effect on thyroid tumor RAIU. Further studies are necessary to determine the best protocol of rhTSH administration to optimize thyroid tumor RAIU.
authors.affiliation: Department of Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. miguel.campos@ugent.be
authors.forename: Miguel
authors.initials: M
authors.lastname: Campos
authors.forename: Kathelijne
authors.initials: K
authors.lastname: Peremans
authors.forename: Eva
authors.initials: E
authors.lastname: Vandermeulen
authors.forename: Luc
authors.initials: L
authors.lastname: Duchateau
authors.forename: Tim
authors.initials: T
authors.lastname: Bosmans
authors.forename: Ingeborgh
authors.initials: I
authors.lastname: Polis
authors.forename: Sylvie
authors.initials: S
authors.lastname: Daminet
mesh_terms: D000818:Animals; D018592:Cross-Over Studies; D004285:Dogs; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D015233:Models, Statistical; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use*; D012107:Research Design; D013961:Thyroid Gland / Q000528:radiation effects; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000662:veterinary*; D013972:Thyrotropin / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes; D011994:Recombinant Proteins; D013972:Thyrotropin