title: GenColors-based comparative genome databases for small eukaryotic genomes.
abstract: Many sequence data repositories can give a quick and easily accessible overview on genomes and their annotations. Less widespread is the possibility to compare related genomes with each other in a common database environment. We have previously described the GenColors database system (http://gencolors.fli-leibniz.de) and its applications to a number of bacterial genomes such as Borrelia, Legionella, Leptospira and Treponema. This system has an emphasis on genome comparison. It combines data from related genomes and provides the user with an extensive set of visualization and analysis tools. Eukaryote genomes are normally larger than prokaryote genomes and thus pose additional challenges for such a system. We have, therefore, adapted GenColors to also handle larger datasets of small eukaryotic genomes and to display eukaryotic gene structures. Further recent developments include whole genome views, genome list options and, for bacterial genome browsers, the display of horizontal gene transfer predictions. Two new GenColors-based databases for two fungal species (http://fgb.fli-leibniz.de) and for four social amoebas (http://sacgb.fli-leibniz.de) were set up. Both new resources open up a single entry point for related genomes for the amoebozoa and fungal research communities and other interested users. Comparative genomics approaches are greatly facilitated by these resources.
authors.affiliation: Genome Analysis Group, Leibniz Institute for Age Research-Fritz Lipmann Institute, Beutenbergstr 11, 07745 Jena, Germany. mfelder@fli-leibniz.de
authors.forename: Marius
authors.initials: M
authors.lastname: Felder
authors.forename: Alessandro
authors.initials: A
authors.lastname: Romualdi
authors.forename: Andreas
authors.initials: A
authors.lastname: Petzold
authors.forename: Matthias
authors.initials: M
authors.lastname: Platzer
authors.forename: Jürgen
authors.initials: J
authors.lastname: Sühnel
authors.forename: Gernot
authors.initials: G
authors.lastname: Glöckner
mesh_terms: D056894:Amoebozoa / Q000235:genetics; D030541:Databases, Genetic; D056890:Eukaryota / Q000235:genetics*; D016681:Genome, Fungal; D023281:Genomics; D020407:Internet; D058977:Molecular Sequence Annotation