title: [Surgical approach to atypical wounds (clinical cases). Subcutaneous ischemic arteriolosclerosis (Martorell ulcer, calciphylaxis, eutrophication)].
abstract: Atypical wounds are probably the most delicate modern medicine topics as well as the most demanding surgical issue. Recently, we submitted an original report of two similar atypical vascular cases at our surgery department. Both presented a rare type of atypical, potentially fatal, vascular illness due to acute ischemic subcutaneous arteriolosclerosis. Because of the strikingly similar common pathophysiological features, Martorell hypertensive ischemic leg ulcer (HYTILU) and calciphylaxis require identical approach and therapy, both systemic and surgical. Even an experienced clinician can easily confuse it with other atypical wounds, namely pyoderma gangrenosum, which due to the corticosteroid induced immunodeficiency can be detrimental, since the two different approach strategies are required. Based on typical localization, necrotic painful skin necroses, progressive local deterioration, often difficult secondary infections along with long term hypertension and diabetes history could elucidate suspicion of ischemic subcutaneous arteriosclerosis. Hypertension (and often diabetes), local findings and histologically proven subcutaneous arteriolosclerosis are mandatory to make the diagnosis. Rapid local amelioration following correct treatment approach additionally confirms the presumed diagnosis. Besides the minutely repetitive surgical debridement, negative wound pressure therapy and split skin transplantation, one should consider systemic medication (analgesics, antioxidants, LMWH, sodium thiosulfate and antibiotics). Considering the cases presented, opportune decisions along with moderate aggressive and modern holistic surgical approach should inevitably resolve hard to heal atypical wounds.
authors.affiliation: Cakovec General Hospital, Department of Surgery, Vascular Division, Zagreb, Croatia. tnovinscak@gmail.com
authors.forename: Tomislav
authors.initials: T
authors.lastname: Novinscak
authors.forename: Marinko
authors.initials: M
authors.lastname: Filipović
authors.forename: Jozinović
authors.initials: J
authors.lastname: Edita
authors.forename: Marijan
authors.initials: M
authors.lastname: Zvorc
authors.forename: Marina
authors.initials: M
authors.lastname: Gradiser
authors.forename: Slavko
authors.initials: S
authors.lastname: Gasparov
mesh_terms: D050379:Arteriolosclerosis / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D002115:Calciphylaxis / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D040521:Subcutaneous Tissue