title: [Gender related metabonomic analysis of serum and urine samples from Xinjiang healthy Han subjects with magnetic resonance].
abstract: OBJECTIVE
  To investigate gender variability in the metabolic serum and urinary profile of healthy Han population in Xinjiang.
  
  
  METHODS
  Serum and urinary samples from 92 healthy Han people in Xinjiang were tested by magnetic resonance based metabonomics and pattern recognition analysis performed with orthogonal partial least-squares discriminant analysis (OPLS-DA). The quality of the model was described by parameter R(2)X, R(2)Y, and Q(2).
  
  
  RESULTS
  The serum in males had higher levels of very low density lipoprotein, low density lipoprotein, unsaturated lipids, creatinine and acetone than in females, whereas females had higher levels of citrate, choline, glucose and amino acids (including isoleucine, leucine, valine, alanine, citrulline, lysine, methionine, glutamate, phenylalanine, threonine, tyrosine, 1-methyl histidine and glycine) than in males. The urine of males had higher levels of formate, malonic acid, taurine, creatinine than that of females, while females had higher levels of hippurate, γ-aminobutyric acid, succinate, citrate and glutamate than males. The model parameters of serum were R(2)X=0.64, R(2)Y=0.70, and Q(2)=0.67, and those of urine were R(2)X=0.17, R(2)Y=0.70, and Q(2)=0.44.
  
  
  CONCLUSIONS
  The blood and urine from Han population in Xinjiang contain a variety of gender related metabolites, which plays an important role in the research of clinical metabonomics.
authors.affiliation: College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China. mtbatu@yahoo.com.cn
authors.forename: Batur
authors.initials: B
authors.lastname: Mamtimin
authors.forename: Qianghui
authors.initials: Q
authors.lastname: Mian
authors.forename: Chunli
authors.initials: C
authors.lastname: Chen
authors.forename: Ayshamgul
authors.initials: A
authors.lastname: Hasim
authors.forename: Li
authors.initials: L
authors.lastname: You
mesh_terms: D000596:Amino Acids / Q000097:blood / Q000652:urine; D001774:Blood Chemical Analysis; D002681:China / Q000208:ethnology; D019343:Citric Acid / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood / Q000652:urine; D008074:Lipoproteins / Q000097:blood / Q000652:urine; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D055442:Metabolome; D055432:Metabolomics / Q000379:methods*; D012737:Sex Factors; D016482:Urinalysis
chemical_list: D000596:Amino Acids; D008055:Lipids; D008074:Lipoproteins; D019343:Citric Acid; D003404:Creatinine