title: A workflow for patient-individualized virtual angiogram generation based on CFD simulation.
abstract: Increasing interest is drawn on hemodynamic parameters for classifying the risk of rupture as well as treatment planning of cerebral aneurysms. A proposed method to obtain quantities such as wall shear stress, pressure, and blood flow velocity is to numerically simulate the blood flow using computational fluid dynamics (CFD) methods. For the validation of those calculated quantities, virtually generated angiograms, based on the CFD results, are increasingly used for a subsequent comparison with real, acquired angiograms. For the generation of virtual angiograms, several patient-specific parameters have to be incorporated to obtain virtual angiograms which match the acquired angiograms as best as possible. For this purpose, a workflow is presented and demonstrated involving multiple phantom and patient cases.
authors.affiliation: Pattern Recognition Lab, Department of Computer Science, Friedrich-Alexander University of Erlangen-Nuremberg, Martensstrasse 3, 91058 Erlangen, Germany. juergen.endres@cs.fau.de
authors.forename: Jürgen
authors.initials: J
authors.lastname: Endres
authors.forename: Markus
authors.initials: M
authors.lastname: Kowarschik
authors.forename: Thomas
authors.initials: T
authors.lastname: Redel
authors.forename: Puneet
authors.initials: P
authors.lastname: Sharma
authors.forename: Viorel
authors.initials: V
authors.lastname: Mihalef
authors.forename: Joachim
authors.initials: J
authors.lastname: Hornegger
authors.forename: Arnd
authors.initials: A
authors.lastname: Dörfler
mesh_terms: D000465:Algorithms; D000792:Angiography; D001783:Blood Flow Velocity / Q000502:physiology*; D003198:Computer Simulation; D003287:Contrast Media / Q000494:pharmacology; D006339:Heart Rate; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology*; D008955:Models, Cardiovascular; D015233:Models, Statistical; D016011:Normal Distribution; D019047:Phantoms, Imaging; D011312:Pressure; D012306:Risk; D033081:Shear Strength; D013314:Stress, Mechanical; D057188:Workflow
chemical_list: D003287:Contrast Media