title: Iron infusion and deposition in the kidney.
abstract: BACKGROUND
  Parenteral iron therapy is the mainstay of treating iron deficiency anemia in chronic kidney disease (CKD) patients.
  
  
  METHODS
  Retrospective case study of iron staining of renal tissues in 2 CKD patients who had received intravenous iron prior to the renal biopsy.
  
  
  RESULTS
  Following the infusion of ferumoxytol, iron staining of renal biopsy demonstrated blue curvilinear deposition of iron in the tissue macrophages (histocytes) and interstitium of the kidney. Renal iron deposition was not observed in a patient administered intravenous iron dextran.
  
  
  CONCLUSIONS
  We postulate that the higher molecular weight of ferumoxytol and different carbohydrate components may lead to deposition and trapping of the ironcarbohydrate complexes in the reticuloendothelial system of the kidney. Potential renal toxicity from iron induced oxidant stress, especially in patients with underlying chronic kidney disease, merits further investigation.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA. ramin.tolouian.@ttuhsc.edu
authors.forename: Ramin
authors.initials: R
authors.lastname: Tolouian
authors.forename: Babak
authors.initials: B
authors.lastname: Rajabi
authors.forename: Darius
authors.initials: D
authors.lastname: Boman
authors.forename: Jorge
authors.initials: J
authors.lastname: Bilbao
authors.forename: Ajay
authors.initials: A
authors.lastname: Gupta
mesh_terms: D000368:Aged; D006801:Humans; D007262:Infusions, Intravenous; D007501:Iron / Q000378:metabolism* / Q000633:toxicity; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D007501:Iron