title: [The role of haemodynamic factors in the development of in-stent restenosis].
abstract: Despite improvements in stent technology, including introduction of drug eluting stents, problem of neointimal hyperplasia  and restenosis remains. These phenomena are associated with multiple risk factors and gene polymorphisms. Well known  periprocedural risk factors of restenosis such as site of stenting, oversizing, implantation of overlapping stents along with  change in vessel geometry affect blood flow conditions. Both experimental and clinical studies provide a number of arguments  regarding importance of hemodynamic factors like oscillatory shear stresses in the process of restenosis. Computational  fluid dynamic (CFD) enables calculation of indices describing fluid flow including tangential shear stress. This method  enables the virtual representation of the physical forces in the flow system and depicting them in graphical form. Flow  modeling is used in the process of designing of coronary stents, which allows for the assessment of restenosis risk in the project  phase. In the nearest future CFD will be used for prediction of restenosis risk after stent implantation.
authors.affiliation: III Klinika i Oddział Kliniczny Kardiologii, Śląski Uniwersytet Medycyny w Katowicach, Śląskie Centrum Chorób Serca, Zabrze, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Wasilewski
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Osadnik
authors.forename: Sylwia
authors.initials: S
authors.lastname: Peryt Stawiarska
authors.forename: Lech
authors.initials: L
authors.lastname: Poloński
mesh_terms: D001783:Blood Flow Velocity; D023903:Coronary Restenosis / Q000209:etiology* / Q000503:physiopathology*; D054855:Drug-Eluting Stents; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D012307:Risk Factors; D015607:Stents / Q000009:adverse effects*