title: D²P²: database of disordered protein predictions.
abstract: We present the Database of Disordered Protein Prediction (D(2)P(2)), available at http://d2p2.pro (including website source code). A battery of disorder predictors and their variants, VL-XT, VSL2b, PrDOS, PV2, Espritz and IUPred, were run on all protein sequences from 1765 complete proteomes (to be updated as more genomes are completed). Integrated with these results are all of the predicted (mostly structured) SCOP domains using the SUPERFAMILY predictor. These disorder/structure annotations together enable comparison of the disorder predictors with each other and examination of the overlap between disordered predictions and SCOP domains on a large scale. D(2)P(2) will increase our understanding of the interplay between disorder and structure, the genomic distribution of disorder, and its evolutionary history. The parsed data are made available in a unified format for download as flat files or SQL tables either by genome, by predictor, or for the complete set. An interactive website provides a graphical view of each protein annotated with the SCOP domains and disordered regions from all predictors overlaid (or shown as a consensus). There are statistics and tools for browsing and comparing genomes and their disorder within the context of their position on the tree of life.
authors.affiliation: Department of Computer Science, University of Bristol, Bristol BS8 1UB, UK. Matt.Oates@bristol.ac.uk
authors.forename: Matt E
authors.initials: ME
authors.lastname: Oates
authors.forename: Pedro
authors.initials: P
authors.lastname: Romero
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishida
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ghalwash
authors.forename: Marcin J
authors.initials: MJ
authors.lastname: Mizianty
authors.forename: Bin
authors.initials: B
authors.lastname: Xue
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Dosztányi
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Uversky
authors.forename: Zoran
authors.initials: Z
authors.lastname: Obradovic
authors.forename: Lukasz
authors.initials: L
authors.lastname: Kurgan
authors.forename: A Keith
authors.initials: AK
authors.lastname: Dunker
authors.forename: Julian
authors.initials: J
authors.lastname: Gough
mesh_terms: D030562:Databases, Protein; D016678:Genome; D020407:Internet; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D020539:Sequence Analysis, Protein
chemical_list: D011506:Proteins