title: Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
abstract: Genome-wide association studies (GWAS) of obesity measures have identified associations with single nucleotide polymorphisms (SNPs). However, no large-scale evaluation of gene-environment interactions has been performed. We conducted a search of gene-environment (G × E) interactions in post-menopausal African-American and Hispanic women from the Women's Health Initiative SNP Health Association Resource GWAS study. Single SNP linear regression on body mass index (BMI) and waist-to-hip circumference ratio (WHR) adjusted for multidimensional-scaling-derived axes of ancestry and age was run in race-stratified data with 871,512 SNPs available from African-Americans (N = 8,203) and 786,776 SNPs from Hispanics (N = 3,484). Tests of G × E interaction at all SNPs for recreational physical activity (m h/week), dietary energy intake (kcal/day), alcohol intake (categorical), cigarette smoking years, and cigarette smoking (ever vs. never) were run in African-Americans and Hispanics adjusted for ancestry and age at interview, followed by meta-analysis of G × E interaction terms. The strongest evidence for concordant G × E interactions in African-Americans and Hispanics was for smoking and marker rs10133840 (Q statistic P = 0.70, beta = -0.01, P = 3.81 × 10(-7)) with BMI as the outcome. The strongest evidence for G × E interaction within a cohort was in African-Americans with WHR as outcome for dietary energy intake and rs9557704 (SNP × kcal = -0.04, P = 2.17 × 10(-7)). No results exceeded the Bonferroni-corrected statistical significance threshold.
authors.affiliation: Center for Human Genetics Research, Vanderbilt Epidemiology Center Institute of Medicine and Public Health, Vanderbilt University, 2525 West End Avenue, Suite 600 6th fl, Nashville, TN 37203, USA.
authors.forename: Digna R
authors.initials: DR
authors.lastname: Velez Edwards
authors.forename: Adam C
authors.initials: AC
authors.lastname: Naj
authors.forename: Keri
authors.initials: K
authors.lastname: Monda
authors.forename: Kari E
authors.initials: KE
authors.lastname: North
authors.forename: Marian
authors.initials: M
authors.lastname: Neuhouser
authors.forename: Oyunbileg
authors.initials: O
authors.lastname: Magvanjav
authors.forename: Ibukun
authors.initials: I
authors.lastname: Kusimo
authors.forename: Mara Z
authors.initials: MZ
authors.lastname: Vitolins
authors.forename: Joann E
authors.initials: JE
authors.lastname: Manson
authors.forename: Mary Jo
authors.initials: MJ
authors.lastname: O'Sullivan
authors.forename: Evadnie
authors.initials: E
authors.lastname: Rampersaud
authors.forename: Todd L
authors.initials: TL
authors.lastname: Edwards
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D015992:Body Mass Index; D002149:Energy Intake; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D049629:Waist-Hip Ratio; D016387:Women's Health