title: New antimicrobial compounds from a marine-derived Bacillus sp.
abstract: In the course of our ongoing research for antimicrobial agents, we isolated five new compounds, three 24-membered macrolactones, macrolactins X-Z (1-3) and two hydroxy unsaturated fatty acids, linieodolides A (5) and B (6), together with a known metabolite, macrolactinic acid (4), from the culture broth of a marine Bacillus sp. The structures of these metabolites were determined on the basis of their spectroscopic data interpretation. Their absolute configurations were addressed by modified Mosher's method and literature data review. Compounds 1-6 showed moderate to potent inhibitory activities (8∼128 μg ml(-1)) against selected pathogenic microorganisms.
authors.affiliation: School of Science and Technology, Bangladesh Open University, Gazipur, Bangladesh.
authors.forename: Mohamad Abdul Mojid
authors.initials: MA
authors.lastname: Mondol
authors.forename: Fakir
authors.initials: F
authors.lastname: Shahidullah Tareq
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Kim
authors.forename: Min Ah
authors.initials: MA
authors.lastname: Lee
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Shin
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001407:Bacillus / Q000378:metabolism*; D004988:Ethers, Cyclic / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D005285:Fermentation; D008386:Marine Biology; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D004988:Ethers, Cyclic; D005231:Fatty Acids, Unsaturated; C570423:macrolactin 1; C570425:macrolactin 2; C570424:macrolactin 3