title: Analysis of neuron-specific enolase and S100B as biomarkers of cognitive decline following surgery in older people.
abstract: OBJECTIVE
  Post-operative cognitive decline is frequent in older individuals following major surgery; however, biomarkers of this decline are less clearly defined.
  
  
  METHODS
  Sixty-eight participants over the age of 60 provided blood samples at baseline and 24 h post-surgery. Cognitive decline was measured at baseline and 52 weeks post-surgery using the Cambridge Assessment for Mental Disorder in the Elderly, section B (CAMCOG) score. Plasma levels of neuron-specific enolase (NSE) and S100B were measured by ELISA.
  
  
  RESULTS
  Baseline NSE and the change in NSE levels between baseline and 24 h were correlated with the change in CAMCOG score between baseline and 52 weeks.
  
  
  CONCLUSIONS
  NSE concentrations may be a useful predictor of individuals at risk of more severe long-term cognitive decline.
authors.affiliation: Wolfson Centre for Age-Related Disease, King's College London, Guy's Campus, London, UK. emma.3.jones@kcl.ac.uk
authors.forename: Emma L
authors.initials: EL
authors.lastname: Jones
authors.forename: Nathan
authors.initials: N
authors.lastname: Gauge
authors.forename: Odd Bjarte
authors.initials: OB
authors.lastname: Nilsen
authors.forename: David
authors.initials: D
authors.lastname: Lowery
authors.forename: Keith
authors.initials: K
authors.lastname: Wesnes
authors.forename: Eirini
authors.initials: E
authors.lastname: Katsaiti
authors.forename: James
authors.initials: J
authors.lastname: Arden
authors.forename: Derek
authors.initials: D
authors.lastname: Amoako
authors.forename: Nicholas
authors.initials: N
authors.lastname: Prophet
authors.forename: Balaji
authors.initials: B
authors.lastname: Purushothaman
authors.forename: David
authors.initials: D
authors.lastname: Green
authors.forename: Clive
authors.initials: C
authors.lastname: Ballard
mesh_terms: D000005:Abdomen / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D003072:Cognition Disorders / Q000097:blood* / Q000209:etiology / Q000523:psychology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D009483:Neuropsychological Tests; D019637:Orthopedic Procedures; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011183:Postoperative Complications / Q000097:blood* / Q000523:psychology*; D012372:ROC Curve; D015203:Reproducibility of Results; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D010751:Phosphopyruvate Hydratase