title: Garlic oil attenuates the cardiac apoptosis in hamster-fed with hypercholesterol diet.
abstract: Hypercholesterolemia is a well established risk factor for cardiac cell apoptosis. The purpose of this study is to evaluate the effects of garlic oil on cardiac apoptosis induced by a hypercholesterol diet. Twenty-four male Golden-Syrian hamsters at 3 months of age were randomly divided into three groups, control, cholesterol and garlic oil groups received a chow diet, chow diet with 2% cholesterol, and chow diet with 2% cholesterol and 1% garlic oil for 8 weeks, respectively. The TUNEL-positive apoptotic cells, and several apoptotic proteins were significantly induced in the excised left ventricle in cholesterol group, whereas significant reduction was observed in cholesterol plus garlic oil group. The IGFI receptor dependent survival pathway was inhibited in cholesterol group whereas it was obviously reversed in cholesterol plus garlic oil group. Our results suggest that administration of garlic oil shows protective effects on cardiac apoptosis in rats with high cholesterol intake.
authors.affiliation: Emergency Department, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Yi-Chang
authors.initials: YC
authors.lastname: Cheng
authors.forename: Mu-Hsin
authors.initials: MH
authors.lastname: Chang
authors.forename: Cheng-Chih
authors.initials: CC
authors.lastname: Tsai
authors.forename: Tung-Sheng
authors.initials: TS
authors.lastname: Chen
authors.forename: Chung-Chen
authors.initials: CC
authors.lastname: Fan
authors.forename: Chien-Chung
authors.initials: CC
authors.lastname: Lin
authors.forename: Chao-Hung
authors.initials: CH
authors.lastname: Lai
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
authors.forename: James A
authors.initials: JA
authors.lastname: Lin
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
mesh_terms: D000498:Allyl Compounds / Q000008:administration & dosage*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D002784:Cholesterol / Q000378:metabolism; D006224:Cricetinae; D004041:Dietary Fats / Q000378:metabolism; D004195:Disease Models, Animal; D005737:Garlic / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000187:drug effects; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008647:Mesocricetus; D011897:Random Allocation; D017526:Receptor, IGF Type 1 / Q000235:genetics / Q000378:metabolism; D013440:Sulfides / Q000008:administration & dosage*
chemical_list: D000498:Allyl Compounds; D002316:Cardiotonic Agents; D004041:Dietary Fats; D013440:Sulfides; C038491:allyl sulfide; D002784:Cholesterol; D017526:Receptor, IGF Type 1