title: Total and HMW adiponectin is independently associated with B-type natriuretic peptide and anemia in chronic hemodialysis patients.
abstract: OBJECTIVE
  A number of vasculo-protective roles have been reported for adiponectin. In contrast, higher, rather than lower, plasma adiponectin levels are associated with an increased risk of cardiovascular disease and mortality in patients undergoing hemodialysis (HD). The mechanisms by which high adiponectin levels are associated with adverse outcome are unclear.
  
  
  METHODS
  This study measured the level of total and high molecular weight (HMW) adiponectins in 70 patients with HD patients (age: 65.2±8.6 years, man/woman: 30/40), and examined the association between adiponectins, metabolic and echocardiographic parameters.
  
  
  RESULTS
  Women had a significantly higher total, HMW levels and HMW to total ratio than men. The levels of total and HMW adiponectin were positively correlated with those of HDL-cholesterol and B-type natriuretic peptide (BNP) levels, and negatively associated with body mass index (BMI), triglyceride, high sensitive-C reactive protein (CRP) and hemoglobin levels. A multiple linear regression analysis showed that HMW adiponectin had an independent association with BMI (β=-0.270, p=0.003), HDL-cholesterol (β=0.356, p<0.001), hemoglobin (β=-0.180, p=0.034) and BNP (β=0.200, p=0.014) as total did adiponectin.
  
  
  CONCLUSIONS
  Anemia and BNP levels had independent influence on the total and HMW adiponectin levels in chronic HD patients.
authors.affiliation: Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University, Japan. yabe@fukuoka-u.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Abe
authors.forename: Tomoji
authors.initials: T
authors.lastname: Matsumae
authors.forename: Satoshi
authors.initials: S
authors.lastname: Eto
authors.forename: Maho
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kenji
authors.initials: K
authors.lastname: Ito
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Sasatomi
authors.forename: Satoru
authors.initials: S
authors.lastname: Ogahara
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nakashima
authors.forename: Takao
authors.initials: T
authors.lastname: Saito
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000368:Aged; D000740:Anemia / Q000097:blood* / Q000209:etiology*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D008076:Cholesterol, HDL / Q000097:blood; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications / Q000628:therapy; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D006435:Renal Dialysis / Q000009:adverse effects; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D006454:Hemoglobins; D020097:Natriuretic Peptide, Brain