title: [Clinical analysis of 134 cases of HEV-related liver failure].
abstract: OBJECTIVE
  To study the clinical features of hepatitis E virus-related liver failure.
  
  
  METHODS
  134 patients with HEV-related liver failure were analyzed retrospectively.
  
  
  RESULTS
  HEV-related liver failure accounted for 8.45 percent of the total number of hepatitis E patients in the hospital. Of the 134 patients, 68 were infected with simple HEV, 66 had the superinfection with HBV. The average age of simple HEV-related liver failure patients (56.12 +/- 14.29) was higher than that of HBV superinfectiong liver failure patients (P < 0.05). The ratio of elderly patients (> or = 60 years) in simple HEV-related liver failure patients (45.59%) was significantly higher than that of the other group (13.64%, P < 0.05). The ratio of direct bilirubin/total bilirubing (0.72 +/- 0.07, 0.69 +/- 0.08), and serum alanine aminotransferase [(1250.90 +/- 1593.97) U/L, (616.26 +/- 797.62) U/L] were significantly higher in simple HEV-related liver failure patients than in HBV superinfectiong liver failure patients (P < 0.05), but the total bilirubing had no significant difference (P > 0.05). The disease outcome and stage were no-significant difference in the two groups (P > 0.05). CONCLUSION; Simple HEV-related liver failure patients may have older age, higher aminotransferase, higher ratio of direct bilirubin/total bilirubin, but disease outcome and stage were no-significant difference in the two groups.
authors.affiliation: 302 Military Hospital, Beijing 100039, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhu
authors.forename: Shao-Li
authors.initials: SL
authors.lastname: You
authors.forename: Hong
authors.initials: H
authors.lastname: Zang
authors.forename: Yi-Hui
authors.initials: YH
authors.lastname: Rong
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Zhang
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Liu
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wan
authors.forename: Shao-Jie
authors.initials: SJ
authors.lastname: Xin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006509:Hepatitis B / Q000821:virology; D006515:Hepatitis B virus / Q000302:isolation & purification / Q000502:physiology; D016751:Hepatitis E / Q000821:virology*; D016752:Hepatitis E virus / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D017093:Liver Failure / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015163:Superinfection / Q000821:virology; D055815:Young Adult