title: Improved oxidative stress and cardio-metabolic status in obese prepubertal children with liver steatosis treated with lifestyle combined with Vitamin E.
abstract: In obese adults with non alcoholic fatty liver disease (NAFLD), treatment with Vitamin E has resulted in an improvement in liver histology, whereas variable and limited results are available in children. Our aim was to assess whether lifestyle combined with supplementation with Vitamin E might reduce oxidative stress and improve cardio-metabolic status in obese children with NAFLD. 24 obese prepubertal children (16M) followed a 6-month lifestyle intervention combined with Vitamin E supplementation (600 mg/day) and they were compared with 21 age and sex-matched obese peers who underwent lifestyle intervention only. At baseline and after 6-month urinary prostaglandin F2α (PGF-2α), endogenous secretory receptor for advanced glycation end products (esRAGE), high sensitivity C-reactive protein (hs-CRP), alanine aminotransferases (ALT), lipid profile, glucose, and insulin were assessed. The two groups were comparable for age (8.3 ± 1.6 vs 8.4 ± 1.3 yr), sex and BMI SDS (2.16 ± 0.29 vs 2.13 ± 0.28). At the beginning of the study, PGF2-α, esRAGE hsCRP, ALT, lipid profile and HOMA-IR levels were similar between the two groups (all p > 0.05). After 6-month treatment, levels of PGF2-α (p < 0.001) significantly decreased and esRAGE significantly increased (p < 0.001) in children treated with Vitamin E. A significant reduction was also found in ALT (p = 0.001), lipid profile and HOMA-IR (p < 0.001). In contrast, no significant change in any of these markers was detected in the lifestyle only group. In conclusion, Vitamin E supplementation was associated with a significant reduction in oxidative stress and improved cardio-metabolic alterations. These data suggest that Vitamin E supplementation could represent a valuable treatment in obese children affected by NAFLD.
authors.affiliation: Department of Pediatrics, University of Chieti, Chieti, Italy. ebe.dadamo@yahoo.com
authors.forename: E
authors.initials: E
authors.lastname: D'Adamo
authors.forename: M L
authors.initials: ML
authors.lastname: Marcovecchio
authors.forename: C
authors.initials: C
authors.lastname: Giannini
authors.forename: T
authors.initials: T
authors.lastname: de Giorgis
authors.forename: V
authors.initials: V
authors.lastname: Chiavaroli
authors.forename: F
authors.initials: F
authors.lastname: Chiarelli
authors.forename: A
authors.initials: A
authors.lastname: Mohn
mesh_terms: D015992:Body Mass Index; D002648:Child; D004032:Diet; D005081:Exercise Therapy; D005234:Fatty Liver / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008019:Life Style; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D018384:Oxidative Stress; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D008055:Lipids; D014810:Vitamin E