title: Photochemical properties and activity of water-soluble polymer/c(60)  nanohybrids for photodynamic therapy.
abstract: Water-soluble star-like poly(vinyl alcohol)/C(60)  and poly{[poly(ethylene glycol) acrylate]-co-(vinyl acetate)}/C(60)  nanohybrids are prepared by grafting macroradicals onto C(60)  and are assessed as photosensitizers for photodynamic therapy. The photophysical and biological properties of both nanohybrids highlight key characteristics influencing their overall efficiency. The macromolecular structure (linear/graft) and nature (presence/absence of hydroxyl groups) of the polymeric arms respectively impact the photodynamic activity and the stealthiness of the nanohybrids. The advantages of both nanohybrids are encountered in a third one, poly[(N-vinylpyrrolidone)-co-(vinyl acetate)]/C(60) , which has linear grafts without hydroxyl groups, and shows a better photodynamic activity.
authors.affiliation: Department of Chemistry, Center for Education and Research on Macromolecules (CERM), B6A, University of Liège, 4000 Liège, Belgium.
authors.forename: Marie
authors.initials: M
authors.lastname: Hurtgen
authors.forename: Antoine
authors.initials: A
authors.lastname: Debuigne
authors.forename: Maryse
authors.initials: M
authors.lastname: Hoebeke
authors.forename: Catherine
authors.initials: C
authors.lastname: Passirani
authors.forename: Nolwenn
authors.initials: N
authors.lastname: Lautram
authors.forename: Ange
authors.initials: A
authors.lastname: Mouithys-Mickalad
authors.forename: Pierre-Henri
authors.initials: PH
authors.lastname: Guelluy
authors.forename: Christine
authors.initials: C
authors.lastname: Jérôme
authors.forename: Christophe
authors.initials: C
authors.lastname: Detrembleur
mesh_terms: D000179:Acrylates / Q000737:chemistry; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use*; D010777:Photochemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry; D012995:Solubility
chemical_list: D000179:Acrylates; D017319:Photosensitizing Agents; D011108:Polymers; D011145:Polyvinyls; C036549:pioloform; D011092:Polyethylene Glycols; D011142:Polyvinyl Alcohol