title: Protein-engineered injectable hydrogel to improve retention of transplanted adipose-derived stem cells.
abstract: Improved retention of transplanted stem cells is achieved through minimally invasive delivery in MITCH, a mixing-induced two-component hydrogel that was engineered to possess shear-thinning and self-healing thixotropic properties. MITCH, an ideal injectable cell-delivery vehicle, supports 3D stem-cell culture, resulting in high cell viability and physiologically relevant cell morphology.
authors.affiliation: Bioengineering, Stanford University, Stanford, CA 94305, USA.
authors.forename: Andreina
authors.initials: A
authors.lastname: Parisi-Amon
authors.forename: Widya
authors.initials: W
authors.lastname: Mulyasasmita
authors.forename: Cindy
authors.initials: C
authors.lastname: Chung
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Heilshorn
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D001704:Biopolymers / Q000737:chemistry* / Q000378:metabolism; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D007267:Injections; D008297:Male; D008422:Materials Testing; D051379:Mice; D008819:Mice, Nude; D008822:Mice, Transgenic; D015202:Protein Engineering / Q000379:methods*; D011994:Recombinant Proteins / Q000737:chemistry* / Q000378:metabolism; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001704:Biopolymers; D011994:Recombinant Proteins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate