title: Effects of piperine, cinnamic acid and gallic acid on rosuvastatin pharmacokinetics in rats.
abstract: The purpose of this study was to investigate the potential pharmacokinetic interactions with natural products (such as piperine (PIP), gallic acid (GA) and cinnamic acid (CA)) and rosuvastatin (RSV) (a specific breast cancer resistance protein, BCRP substrate) in rats. In Caco2 cells, the polarized transport of RSV was effectively inhibited by PIP, CA and GA at concentration of 50 μM. After per oral (p.o.) coadministration of PIP, CA and GA (10 mg/kg) significantly increased intravenous exposure (AUC(last)) of RSV (1 mg/kg) by 73.5%, 62.9% and 53.3% (p < 0.05), respectively than alone group (control). Compared with the control (alone) group, p.o. coadministration of PIP, CA and GA (10 mg/kg) significantly increased the oral exposure (AUC(last)) of RSV (5 mg/kg) by 2.0-fold, 1.83-fold (p < 0.05) and 2.34 -fold (p < 0.05), respectively. Moreover, the cumulative biliary excretion of RSV (5 mg/kg, p.o.) was significantly decreased by 53.3, 33.4 and 39.2% at the end of 8 h after p.o. co-administration of PIP, CA and GA (10 mg/kg), respectively. Taken together, these results indicate that the natural products such as PIP, CA and GA significantly inhibit RSV transport in to bile and increased the plasma exposure (AUC(last)) of RSV.
authors.affiliation: Drug Metabolism and Pharmacokinetics -Toxicology Division, Sai Advantium Pharma Ltd, Building 1, Plot No. 2, Chrysalis Enclave, International Biotech Park, Phase - 2, Hinjewadi, Pune, 411057, India.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Basu
authors.forename: Snehasis
authors.initials: S
authors.lastname: Jana
authors.forename: Vandana B
authors.initials: VB
authors.lastname: Patel
authors.forename: Hitesh
authors.initials: H
authors.lastname: Patel
mesh_terms: D000284:Administration, Oral; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D019540:Area Under Curve; D052117:Benzodioxoles / Q000494:pharmacology*; D001646:Bile / Q000737:chemistry; D002934:Cinnamates / Q000494:pharmacology*; D004285:Dogs; D004347:Drug Interactions; D005464:Fluorobenzenes / Q000097:blood / Q000493:pharmacokinetics*; D005707:Gallic Acid / Q000494:pharmacology*; D061985:Madin Darby Canine Kidney Cells; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000494:pharmacology*; D011743:Pyrimidines / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D002934:Cinnamates; D005464:Fluorobenzenes; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D011743:Pyrimidines; D013449:Sulfonamides; C029010:cinnamic acid; D005707:Gallic Acid; D000068718:Rosuvastatin Calcium; C008922:piperine