title: Hypoglycemia associated with L-asparaginase in acute lymphoblastic leukemia treatment: a case report.
abstract: A patient with acute lymphoblastic leukemia repeatedly developed hypoglycemia during chemotherapy. Comparison of serum glucose trends between chemotherapy with and without L-asparaginase (L-Asp) demonstrated a strong association between L-Asp and hypoglycemia. Critical blood sampling during hypoglycemia indicated hyperinsulinism, suggesting that L-Asp induced hypoglycemia in the patient through inappropriate insulin secretion. Identification of hypoglycemia as an adverse effect will enable clinicians to understand and develop appropriate strategies for L-Asp use in chemotherapy regimens.
authors.affiliation: Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. hshimada@a5.keio.jp.
authors.forename: Ryuma
authors.initials: R
authors.lastname: Tanaka
authors.forename: Tomoo
authors.initials: T
authors.lastname: Osumi
authors.forename: Masashi
authors.initials: M
authors.lastname: Miharu
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ishii
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Takao
authors.initials: T
authors.lastname: Takahashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimada