title: Recurrent solitary fibrous tumor of the pleura with malignant transformation and non-islet cell tumor-induced hypoglycemia due to paraneoplastic overexpression and secretion of high-molecular-weight insulin-like growth factor II.
abstract: A 41-year-old man was diagnosed with a solitary fibrous tumor (SFT) of the pleura in the posterior mediastinum. Despite two surgeries for excision, the SFT recurred and progressed with direct invasion of the chest wall and bone metastases. He was hospitalized because of cerebral infarction and presented with recurrent severe hypoglycemia fourteen years later. High-molecular-weight (HMW) insulin-like growth factor II (IGF-II) was identified in the serum and tumor using Western blotting and immunohistochemistry. These findings suggested that the cause of the recurrent severe hypoglycemia was SFT production of HMW IGF-II, a mediator of non-islet cell tumor-induced hypoglycemia (NICTH).
authors.affiliation: Division of Nephrology and Metabolism, Kanto Rosai Hospital, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Tominaga
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kawarasaki
authors.forename: Keiko
authors.initials: K
authors.lastname: Kanemoto
authors.forename: Akio
authors.initials: A
authors.lastname: Yokochi
authors.forename: Keishi
authors.initials: K
authors.lastname: Sugino
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Hatanaka
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Uekusa
authors.forename: Izumi
authors.initials: I
authors.lastname: Fukuda
authors.forename: Motohiko
authors.initials: M
authors.lastname: Aiba
authors.forename: Naomi
authors.initials: N
authors.lastname: Hizuka
authors.forename: Susumu
authors.initials: S
authors.lastname: Uda
mesh_terms: D000328:Adult; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007335:Insulin-Like Growth Factor II / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D009384:Paraneoplastic Endocrine Syndromes / Q000473:pathology / Q000503:physiopathology*; D054363:Solitary Fibrous Tumor, Pleural / Q000378:metabolism* / Q000473:pathology
chemical_list: D007335:Insulin-Like Growth Factor II