title: A hypervariable STR polymorphism in the CFI gene: mutation rate and no linkage disequilibrium with FGA.
abstract: A hypervariable short tandem repeat (STR) polymorphism in intron 7 of the human complement factor I gene (CFI) was investigated to estimate the mutation rate in Japanese samples and to test linkage disequilibrium (LD) with an STR in the fibrinogen alpha chain gene (FGA). The expected heterozygosity and the mutation rate of CFI were estimated to be 0.917 and 0.002, respectively. No LD was observed between CFI and FGA. CFI is a useful supplementary marker for forensic science.
authors.affiliation: Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan. yuasai@med.tottori-u.ac.jp
authors.forename: Isao
authors.initials: I
authors.lastname: Yuasa
authors.forename: Nori
authors.initials: N
authors.lastname: Nakayashiki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umetsu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nishimukai
authors.forename: Aya
authors.initials: A
authors.lastname: Matsusue
authors.forename: Koji
authors.initials: K
authors.lastname: Dewa
mesh_terms: D044466:Asian People / Q000235:genetics; D017244:Complement Factor I / Q000235:genetics*; D005340:Fibrinogen / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D059645:Mutation Rate; D010446:Peptide Fragments / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D010446:Peptide Fragments; C098000:fibrinogen alphaC; D005340:Fibrinogen; D017244:Complement Factor I