title: Gene-environment interactions between methylenetetrahydrofolate reductase (MTHFR) 677C>T and metabolic syndrome for the prevalence of ischemic stroke in Koreans.
abstract: Although metabolic syndrome (MS) is recognized as a risk factor for ischemic stroke, little is known about genetic variants that confer susceptibility to ischemic stroke among individuals with or without MS. This study was completed to investigate whether the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is associated with MS as a risk factor for ischemic stroke in the Korean population. The prevalence of MS was significantly higher in ischemic stroke patients than controls (adjusted odds ratio [AOR]=1.420; 95% confidence interval [CI]=1.017-1.982, P=0.040). MS prevalence was also significantly different between patients with subtypes of small-artery occlusion (AOR=1.707; 95% CI=1.081-2.695, P=0.022) and large-artery occlusion (AOR=1.661; 95% CI=1.089-2.534, P=0.019) versus controls. The frequencies of the MTHFR 677 TT genotype (AOR=3.001; 95% CI=1.487-6.057, P=0.002) and CT genotype (AOR=1.772; 95% CI=1.053-2.983, P=0.031) of the MS group, and for the CC genotype in those without MS were significantly different between the ischemic stroke patients and controls. The MTHFR 677C>T polymorphism was associated with a higher risk of MS among ischemic stroke patients in the Korean population.
authors.affiliation: Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Ok Joon
authors.initials: OJ
authors.lastname: Kim
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Hong
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Seung Hun
authors.initials: SH
authors.lastname: Oh
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Kim
authors.forename: Young Seok
authors.initials: YS
authors.lastname: Park
authors.forename: Eo Jin
authors.initials: EJ
authors.lastname: Kim
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D044466:Asian People; D002545:Brain Ischemia / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D020521:Stroke / Q000208:ethnology / Q000209:etiology / Q000235:genetics*
chemical_list: D008754:Methylenetetrahydrofolate Dehydrogenase (NADP)