title: [Therapeutic goal of vitamin D: optimal serum level and dose requirements].
abstract: Therapeutic goal of vitamin D: optimal serum level and dose requirements Results of randomized controlled trials and meta-analyses investigating the effect of vitamin D supplementation on falls and fractures are inconsistent. The optimal serum level 25(OH) vitamin D for musculoskeletal and global health is > or = 30 ng/ml (75 nmol/l) for some experts and 20 ng/ml (50 nmol/l) for some others. A daily dose of vitamin D is better than high intermittent doses to reach this goal. High dose once-yearly vitamin D therapy may increase the incidence of fractures and falls. High serum level of vitamin D is probably harmful for the musculoskeletal system and health at large. The optimal benefits for musculoskeletal health are obtained with an 800 UI daily dose and a serum level of near 30 ng/ml (75 nmol/l).
authors.affiliation: Service de médecine interne, Département de médicine, Centre des maladies osseuses, CHUV, 1011 Lausanne. olivier.lamy@chuv.ch
authors.forename: O
authors.initials: O
authors.lastname: Lamy
authors.forename: B
authors.initials: B
authors.lastname: Aubry-Rozier
authors.forename: D
authors.initials: D
authors.lastname: Stoll
mesh_terms: D050723:Fractures, Bone / Q000517:prevention & control; D006801:Humans; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood*
chemical_list: D014807:Vitamin D