title: Degradable magnesium-based implant materials with anti-inflammatory activity.
abstract: The objective of this study was to prepare a new biodegradable Mg-based biomaterial, which provides good mechanical integrity in combination with anti-inflammatory function during the degradation process. The silver element was used, because it improved the mechanical properties as an effective grain refiner and it is also treated as a potential anti-inflammatory core. The new degradable Mg-Zn-Ag biomaterial was prepared by zone solidification technology and extrusion. The mechanical properties were mostly enhanced by fine grain strengthening. In addition, the alloys exhibited good cytocompatibility. The anti-inflammatory function of degradation products was identified by both interleukin-1α and nitric oxide modes. The anti-inflammatory impact was significantly associated with the concentration of silver ion. It was demonstrated that Mg-Zn-Ag system was a potential metallic stent with anti-inflammatory function, which can reduce the long-term dependence of anti-inflammatory drug after coronary stent implantation.
authors.affiliation: State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, People's Republic of China. pengqiuming@gmail.com
authors.forename: Qiuming
authors.initials: Q
authors.lastname: Peng
authors.forename: Kun
authors.initials: K
authors.lastname: Li
authors.forename: Zengsheng
authors.initials: Z
authors.lastname: Han
authors.forename: Erde
authors.initials: E
authors.lastname: Wang
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Xu
authors.forename: Riping
authors.initials: R
authors.lastname: Liu
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000497:Alloys; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000494:pharmacology; D001826:Body Fluids / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D004343:Drug Implants; D004563:Electrochemistry; D006244:Hardness; D006367:HeLa Cells; D006801:Humans; D007202:Indicators and Reagents; D053582:Interleukin-1alpha / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D017616:Magnesium Compounds / Q000008:administration & dosage* / Q000494:pharmacology*; D055595:Mechanical Phenomena; D008855:Microscopy, Electron, Scanning; D009569:Nitric Oxide / Q000378:metabolism; D010316:Particle Size; D018030:Silver Compounds / Q000737:chemistry; D012996:Solutions; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D000497:Alloys; D000893:Anti-Inflammatory Agents; D001672:Biocompatible Materials; D004343:Drug Implants; D007202:Indicators and Reagents; D053582:Interleukin-1alpha; D017616:Magnesium Compounds; D018030:Silver Compounds; D012996:Solutions; D017967:Zinc Compounds; D009569:Nitric Oxide