title: [Enterobacteriaceae producing extended spectrum beta-lactamase: epidemiology, risk factors, and prevention].
abstract: Multidrug-resistant bacteria are a major worldwide health public concern. It results from the growing increase in antibiotic prescriptions, which are responsible for selection pressure on bacteria. In France like in other countries, enterobacteriaceae producing extended spectrum beta-lactamase (EESBL) are the predominant multidrug-resistant bacteria. EESBL may be responsible for severe infections and require prescription of broad-spectrum antibacterial agents. The current EESBL outbreak is different from methicillin-resistant Staphylococcus aureus outbreak that occurred in the early 1980. Consistently, EESBL are isolated both in hospital and community. Moreover, standard hygiene measures appear ineffective since EESBL prevalence is still increasing. The current inability to contain EESBL outbreak is due to several factors, including the existence of a wide community- and hospital-acquired tank of EESBL, failure to follow strict rules for hygiene, and the current irrational prescription of antibiotics.
authors.affiliation: Service de réanimation médicale et toxicologique, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France. Electronic address: dominique.vodovar@gmail.com.
authors.forename: D
authors.initials: D
authors.lastname: Vodovar
authors.forename: G
authors.initials: G
authors.lastname: Marcadé
authors.forename: L
authors.initials: L
authors.lastname: Raskine
authors.forename: I
authors.initials: I
authors.lastname: Malissin
authors.forename: B
authors.initials: B
authors.lastname: Mégarbane
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control*; D005602:France / Q000453:epidemiology; D005843:Geography; D006801:Humans; D012307:Risk Factors; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases