title: Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention.
abstract: The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.
authors.affiliation: Department of Pharmacology, College of Pharmaceutical Sciences; Soochow University, Jiangsu, China. zhangyi@suda.edu.cn
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D004734:Energy Metabolism; D005973:Glutamine / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D005973:Glutamine