title: Photo-controllable DNA origami nanostructures assembling into predesigned multiorientational patterns.
abstract: We demonstrate a novel strategy for constructing multidirectional programmed 2D DNA nanostructures in various unique patterns by introducing photoresponsive oligonucleotides (Azo-ODNs) into hexagonal DNA origami structures. We examined regulation of assembly and disassembly of DNA nanostructures reversibly by different photoirradiation conditions in a programmed manner. Azo-ODNs were incorporated to the hexagonal DNA origami structures, which were then employed as self-assembly units for building up nanosized architectures in regulated arrangements. By adjusting the numbers and the positions of Azo-ODNs in the hexagonal units, the specific nanostructures with face controlling can be achieved, resulting in construction of ring-shaped nanostructures. By combining DNA origami strategy with photoregulating system, remote controlling of assembly and disassembly of DNA nanostructures has been accomplished simply by photo irradiation.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Yang
authors.forename: Masayuki
authors.initials: M
authors.lastname: Endo
authors.forename: Kumi
authors.initials: K
authors.lastname: Hidaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D019281:Dimerization; D049329:Nanostructures / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods; D009690:Nucleic Acid Conformation / Q000528:radiation effects; D009841:Oligonucleotides / Q000737:chemistry*; D055668:Photochemical Processes
chemical_list: D009841:Oligonucleotides; D004247:DNA