title: Hydrometallation-asymmetric conjugate addition: application to complex molecule synthesis.
abstract: Copper catalysis allows alkyl zirconium species, generated in situ from alkenes, to undergo conjugate addition reactions. A hydrometallation-catalytic asymmetric 1,4-addition was used to synthesize either enantiomer of a natural product in one step from commercially available materials. Hydrometallation-addition sequences applied to steroids containing a cross-conjugated dienone or 1,6-acceptor give highly functionalized products.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Maksymowicz
authors.forename: Philippe M C
authors.initials: PM
authors.lastname: Roth
authors.forename: Amber L
authors.initials: AL
authors.lastname: Thompson
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Fletcher