title: 4,5-seco-guaiane and a nine-membered sesquiterpene lactone from Holostylis reniformis.
abstract: Root extracts of Holostylis reniformis (Aristolochiaceae) yielded three new natural sesquiterpenes, a sesquiterpene with an unusual carbon skeleton, 4,5-seco-guaiane (7-epi-11-hydroxychabrolidione A, 1), a nine-membered lactone with new carbon skeleton (holostylactone, 2), and a new megastigmane [(6S,7E)-6,9-dihydroxy-10-(2'-hydroxy-ethoxy)-4,7-megastigmadien-3-one, 3], together with bulnesol and sitosterol-3-O-&#946;-D-glucopyranoside. The structures of these compounds were determined by spectroscopic analyses and B3LYP/STO-3G** theoretical studies.
authors.affiliation: Institute of Chemistry, São Paulo State University, UNESP, C.P. 355, 14801-970 Araraquara, SP, Brazil.
authors.forename: Marcos D P
authors.initials: MD
authors.lastname: Pereira
authors.forename: Tito
authors.initials: T
authors.lastname: da Silva
authors.forename: Lucia M X
authors.initials: LM
authors.lastname: Lopes
authors.forename: Antoniana U
authors.initials: AU
authors.lastname: Krettli
authors.forename: Lucas S
authors.initials: LS
authors.lastname: Madureira
authors.forename: Julio
authors.initials: J
authors.lastname: Zukerman-Schpector
mesh_terms: D029065:Aristolochiaceae / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C421026:guaiane