title: [Expression and significance of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue].
abstract: OBJECTIVE
  To investigate the expression of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue and relationship with progression of breast carcinoma.
  
  
  METHODS
  92 cases of breast carcinoma tissue and homologous paraneoplastic breast tissue were selected, expressive level of HER-2/neu mRNA and RECK mRNA were detected with RT-PCR, expressive difference of HER-2/neu mRNA and RECK mRNA were contrasted between breast carcinoma tissue and homologous paraneoplastic breast tissue, along with different TNM stage breast carcinoma tissue and differentiate breast carcinoma.
  
  
  RESULTS
  The level of HER-2/neu mRNA was higher and RECK mRNA was lower in breast carcinoma tissue than homologous paraneoplastic breast tissue, the expressive level of HER-2/neu mRNA and RECK mRNA was remarkably different along with different TNM stage breast carcinoma tissue and differentiate breast carcinoma, there was a negative correlation between expressive level of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue.
  
  
  CONCLUSIONS
  Expression of HER-2/neu mRNA and RECK mRNA was abnormal in breast carcinoma tissue, HER-2/neu mRNA and RECK mRNA regulate each other and mutual participate occurrence and progression of breast carcinoma.
authors.affiliation: Jiangsu Cancer Hospital, Affiliated to Nanjing Medical University, Nanjing 210009, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
authors.forename: Jia
authors.initials: J
authors.lastname: Chen
authors.forename: Ma-Qing
authors.initials: MQ
authors.lastname: Zheng
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Xu
authors.forename: Da
authors.initials: D
authors.lastname: Wei
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Feng
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002277:Carcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*
chemical_list: D058851:GPI-Linked Proteins; D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases; C115460:RECK protein, human; C508053:ERBB2 protein, human