title: Omega-6 fatty acids and risk of heart failure in the Physicians' Health Study.
abstract: BACKGROUND
  Although 1 in 5 adults will develop heart failure (HF) in their lifetime, data on the effect of plasma omega-6 (n-3) PUFAs on risk of HF are currently sparse.
  
  
  OBJECTIVE
  We investigated whether plasma phospholipid omega-6 concentrations are associated with risk of HF in US male physicians. In a secondary analysis, we evaluated whether such an association differs between HF with and without previous myocardial infarction (MI).
  
  
  METHODS
  With the use of a nested case-control design, this ancillary study comprised 788 cases and 788 matched controls from the Physicians' Health Study. Plasma omega-6 PUFAs were measured by using gas chromatography.
  
  
  RESULTS
  The mean age of subjects was 58.7 y with a mean follow-up time of 17.1 y. We did not show any evidence of a statistically significant relation between total omega-6 PUFAs and HF [OR (95% CI): 1.00; 0.85 (0.63, 1.14); 0.84 (0.63, 1.13); and 0.87 (0.63, 1.20) across consecutive quartiles of omega-6 PUFAs; P-linear trend = 0.39]. Results were similar for HF with and without previous MI.
  
  
  CONCLUSIONS
  Our data showed no significant association between total plasma omega-6 PUFAs and risk of developing HF.
authors.affiliation: Brigham and Women's Hospital, Boston, MA 02120, USA.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Petrone
authors.forename: Natalie
authors.initials: N
authors.lastname: Weir
authors.forename: Naomi Q
authors.initials: NQ
authors.lastname: Hanson
authors.forename: Robert
authors.initials: R
authors.lastname: Glynn
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Tsai
authors.forename: J Michael
authors.initials: JM
authors.lastname: Gaziano
authors.forename: Luc
authors.initials: L
authors.lastname: Djoussé
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002849:Chromatography, Gas; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology
chemical_list: D043371:Fatty Acids, Omega-6