title: Metal-catalyzed syntheses of abridged CDE rings of rubriflordilactones A and B.
abstract: The development of complementary palladium- and cobalt-catalyzed approaches to tricyclic arylsilanes suitable for elaboration into the CDE ring systems of rubriflordilactones A and B is reported. Microwave conditions are required to effect a cobalt-catalyzed triyne cyclotrimerization, which critically depends on the substitution pattern of the triyne termini. Mild conditions to elaborate these arylsilanes to the CDE cores of the natural products are described.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
authors.forename: Shermin S
authors.initials: SS
authors.lastname: Goh
authors.forename: Hannah
authors.initials: H
authors.lastname: Baars
authors.forename: Birgit
authors.initials: B
authors.lastname: Gockel
authors.forename: Edward A
authors.initials: EA
authors.lastname: Anderson
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry; D013237:Stereoisomerism; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D014315:Triterpenes; C514794:rubriflordilactone A; C514795:rubriflordilactone B; D010165:Palladium