title: Surgical desensitisation of the mechanoreceptors in Müller's muscle relieves chronic tension-type headache caused by tonic reflexive contraction of the occipitofrontalis muscle in patients with aponeurotic blepharoptosis.
abstract: Proprioceptively innervated intramuscular connective tissues in Müller's muscle function as exterior mechanoreceptors to induce reflex contraction of the levator and occipitofrontalis muscles. In aponeurotic blepharoptosis, since the levator aponeurosis is disinserted from the tarsus, stretching of the mechanoreceptors in Müller's muscle is increased even on primary gaze to induce phasic and tonic reflexive contraction of the occipitofrontalis muscle. It was hypothesised that in certain patients with aponeurotic blepharoptosis, the presence of tonic reflexive contraction of the occipitofrontalis muscle due to the sensitised mechanoreceptors in Müller's muscle, can cause chronic tension-type headache (CTTH) associated with occipitofrontalis tenderness. To verify this hypothesis, this study evaluated (1) what differentiates patients with CTTH from patients without CTTH, (2) how pharmacological contraction of Müller's smooth muscle fibres as a method for desensitising the mechanoreceptors in Müller's muscle affects electromyographic activity of the frontalis muscle, and (3) how surgical aponeurotic reinsertion to desensitise the mechanoreceptors in Müller's muscle electromyographically or subjectively affects activities of the occipitofrontalis muscle or CTTH. It was found that patients had sustained CTTH when light eyelid closure did not markedly reduce eyebrow elevation. However, pharmacological contraction of Müller's smooth muscle fibres or surgery to desensitise the mechanoreceptor electromyographically reduced the tonic contraction of the occipitofrontalis muscle on primary gaze and subjectively relieved aponeurotic blepharoptosis-associated CTTH. Over-stretching of the mechanoreceptors in Müller's muscle on primary gaze may induce CTTH due to tonic reflexive contraction of the occipitofrontalis muscle. Therefore, surgical desensitisation of the mechanoreceptors in Müller's muscle appears to relieve CTTH.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. kmatsuo@shinshu-u.ac.jp
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Matsuo
authors.forename: Ryokuya
authors.initials: R
authors.lastname: Ban
mesh_terms: D000328:Adult; D019882:Blepharoplasty / Q000379:methods; D001763:Blepharoptosis / Q000150:complications / Q000175:diagnosis* / Q000601:surgery*; D001767:Blinking / Q000502:physiology; D002908:Chronic Disease; D015331:Cohort Studies; D005152:Facial Muscles / Q000187:drug effects / Q000294:innervation* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008465:Mechanoreceptors / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D009801:Oculomotor Muscles / Q000294:innervation / Q000503:physiopathology; D010147:Pain Measurement; D010656:Phenylephrine / Q000008:administration & dosage*; D018570:Risk Assessment; D012720:Severity of Illness Index; D018781:Tension-Type Headache / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D010656:Phenylephrine