title: PPARγ agonist from Chromolaena odorata.
abstract: A phytochemical investigation of Chromolaena odorata resulted in the isolation of five new compounds, 5aα,6,9,9aβ,10-pentahydro-10β-hydroxy-7-methylanthra[1,2-d][1,3]dioxol-5-one (1), 1,2-methylenedioxy-6-methylanthraquinone (2), 3-hydroxy-1,2,4-trimethoxy-6-methylanthraquinone (3), 3-hydroxy-1,2-dimethoxy-6-methylanthraquinone (4), and 7-methoxy-7-epi-medioresinol (5), together with 12 known compounds, odoratin (6), 3β-acetyloleanolic acid (7), ursolic acid (8), ombuin (9), 4,2'-dihydroxy-4',5',6'-trimethoxychalcone (10), (-)-pinoresinol (11), austrocortinin (12), tianshic acid (13), cleomiscosin D (14), (-)-medioresinol (15), (-)-syringaresinol (16), and cleomiscosin A (17). All the compounds were evaluated for their PPARγ transactivation activity, and compound 6 showed moderate activity with an EC(50) value of 3.10 μM.
authors.affiliation: School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, People's Republic of China. zhang-manli@163.com
authors.forename: Man-Li
authors.initials: ML
authors.lastname: Zhang
authors.forename: Dianne
authors.initials: D
authors.lastname: Irwin
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Li
authors.forename: Françoise
authors.initials: F
authors.lastname: Sauriol
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Shi
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Wang
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Huo
authors.forename: Li-Geng
authors.initials: LG
authors.lastname: Li
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Gu
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Shi
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D036604:Chromolaena / Q000737:chemistry*; D004149:Dioxoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008156:Luciferases / Q000378:metabolism; D015394:Molecular Structure; D047495:PPAR gamma / Q000819:agonists*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000880:Anthraquinones; D004149:Dioxoles; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D005663:Furans; D017705:Lignans; D047495:PPAR gamma; D012717:Sesquiterpenes; C042192:syringaresinol; C018119:odoratin; D008156:Luciferases; C073955:2-methylanthraquinone; C103298:pinoresinol