title: Merkel cell carcinoma: a systematic review of ENT presentations.
abstract: The aim of this study was to perform a systematic literature review of Merkel cell carcinomas (MCCs) originating exclusively in the ear, nose and throat (ENT) district. An appropriate string was run on PubMed to retrieve articles dealing with ENT presentations of MCC. A double cross-check was performed on citations and full-text articles found using the selected inclusion and exclusion criteria. In total, 43 articles were finally included in the study, describing 51 cases of MCC involving the ENT region: 22/51 (43%) cases involving the ear; 20/51 (39%) cases involving the mucosal sites; 9/51 (18%) cases involving other ENT regions. Patients with mucosal site involvement showed a higher mortality rate from the disease (45%) in comparison with the other two groups, especially when compared with those patients having primary involvement of the ear (22%). The ENT specialist should suspect and consider MCC, especially in elderly patients presenting with a suspicious lesion of the auricular pavilion, so as to avoid misdiagnosis and delayed treatments.
authors.affiliation: Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100 Modena, Italy. giox83@hotmail.com
authors.forename: Federico Maria
authors.initials: FM
authors.lastname: Gioacchini
authors.forename: Valentina
authors.initials: V
authors.lastname: Postacchini
authors.forename: Oriana
authors.initials: O
authors.lastname: Simonetti
authors.forename: Annamaria
authors.initials: A
authors.lastname: Offidani
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Magliulo
authors.forename: Massimo
authors.initials: M
authors.lastname: Re
mesh_terms: D015266:Carcinoma, Merkel Cell / Q000473:pathology* / Q000628:therapy; D004423:Ear / Q000473:pathology; D006801:Humans; D009092:Mucous Membrane / Q000473:pathology; D009666:Nose / Q000473:pathology; D010039:Otorhinolaryngologic Neoplasms / Q000473:pathology* / Q000628:therapy; D010306:Parotid Gland / Q000473:pathology; D010307:Parotid Neoplasms / Q000473:pathology* / Q000628:therapy; D010614:Pharynx / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*