title: Molecular pathogenesis of neuromyelitis optica.
abstract: Neuromyelitis optica (NMO) is a rare autoimmune disorder, distinct from multiple sclerosis, causing inflammatory lesions in the optic nerves and spinal cord. An autoantibody (NMO IgG) against aquaporin-4 (AQP4), a water channel expressed on astrocytes is thought to be causative. Peripheral production of the antibody is triggered by an unknown process in genetically susceptible individuals. Anti-AQP4 antibody enters the central nervous system (CNS) when the blood brain barrier is made permeable and has high affinity for orthogonal array particles of AQP4. Like other autoimmune diseases, Th17 cells and their effector cytokines (such as interleukin 6) have been implicated in pathogenesis. AQP4 expressing peripheral organs are not affected by NMO IgG, but the antibody causes extensive astrocytic loss in specific regions of the CNS through complement mediated cytotoxicity. Demyelination occurs during the inflammatory process and is probably secondary to oligodendrocyte apoptosis subsequent to loss of trophic support from astrocytes. Ultimately, extensive axonal injury leads to severe disability. Despite rapid advances in the understanding of NMO pathogenesis, unanswered questions remain, particularly with regards to disease mechanisms in NMO IgG seronegative cases. Increasing knowledge of the molecular pathology is leading to improved treatment strategies.
authors.affiliation: School of Medicine, Gold Coast Campus, Griffith University, QLD 4222, Australia. w.bukhari@griffith.edu.au.
authors.forename: Wajih
authors.initials: W
authors.lastname: Bukhari
authors.forename: Michael H
authors.initials: MH
authors.lastname: Barnett
authors.forename: Kerri
authors.initials: K
authors.lastname: Prain
authors.forename: Simon A
authors.initials: SA
authors.lastname: Broadley
mesh_terms: D000818:Animals; D051401:Aquaporin 4 / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D006680:HLA Antigens / Q000276:immunology / Q000378:metabolism; D006801:Humans; D009471:Neuromyelitis Optica / Q000378:metabolism / Q000473:pathology*; D011110:Polymorphism, Genetic; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D051401:Aquaporin 4; D001323:Autoantibodies; D016207:Cytokines; D006680:HLA Antigens