title: Effects of dietary fish oil and corn oil on rat mammary tissue.
abstract: The effects, on the maternal mammary gland, of diets containing similar lipid percentages but differing in composition of polyunsaturated fatty acids (PUFA) have been assessed in rats during pregnancy and lactation. For this purpose, tuna fish oil (an n-3-PUFA-enriched oil) and corn oil (an n-6-PUFA-enriched oil) were included in diets at ratios such that the caloric inputs were the same as that of the control diet. As expected, the maternal diet affected the tissue composition of dams. Unexpectedly, only the tuna fish oil diet had an effect on pup growth, being associated with the pups being underweight between the ages of 11 and 21 days. The maternal mammary gland of rats fed the tuna fish oil diet displayed two main modifications: the size of cytoplasmic lipid droplets was increased when compared with those in control rats and the mammary epithelium showed an unusual formation of multilayers of cells. These results show that the tuna fish oil diet, during pregnancy and lactation, exerts specific effects on mammary cells and on the formation of lipid droplets. They suggest that this maternal diet affects the functioning of the mammary tissue.
authors.affiliation: INRA, UR0909 Nutrition et Régulation Lipidique des Fonctions Cérébrales, 78352, Jouy-en-Josas cedex, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Delpal
authors.forename: Alain
authors.initials: A
authors.lastname: Pauloin
authors.forename: Catherine
authors.initials: C
authors.lastname: Hue-Beauvais
authors.forename: Valérie
authors.initials: V
authors.lastname: Berthelot
authors.forename: Philippe
authors.initials: P
authors.lastname: Schmidely
authors.forename: Michèle
authors.initials: M
authors.lastname: Ollivier-Bousquet
mesh_terms: D000818:Animals; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology; D043371:Fatty Acids, Omega-6 / Q000494:pharmacology; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D051272:Glucose Transporter Type 1 / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000648:ultrastructure; D008565:Membrane Proteins / Q000378:metabolism; D008892:Milk / Q000378:metabolism; D000070780:Perilipin-2; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005395:Fish Oils; D051272:Glucose Transporter Type 1; D008565:Membrane Proteins; D000070780:Perilipin-2; C495679:Slc2a1 protein, rat