title: Anthelmintic activity of papaya seeds on Hymenolepis diminuta infections in rats.
abstract: The purpose of this study is to see the anthelmintic activity potential of papaya   seeds against Hymenolepis diminuta in rats. The objectives of this study were: (1) to   determine the effectiveness of papaya seeds on helminths especially H. diminuta in rats and   (2) to determine the effective dose level on helminths in rats. Thirty six male rats from strain   Sprague-Dawley were chosen as samples in this experiment. Two types of dose level were   used for papaya seeds treatments such as 0.6 g kg-1 and 1.2 g kg-1. The geometric mean (GEM)   was used to calculate mean for eggs per gram (EPG) before and after the treatment to be   included in the reduction percentage calculation. After 21 days post treatment, necropsies   were done to get the worm count and the GEM was used to calculate the efficacy percentage   for the treatment. Results from this study showed that the reduction percentages in EPG for   papaya seeds treatment for both doses level were very high which is 96.8% for 0.6g kg-1 dose   level and 96.2% for 1.2 g kg-1 dose level. Whereas the efficacy percentage based on the worm   counts for both doses level were also very high that was 90.77% for 0.6 g kg-1 dose level and   93.85% for 1.2 g kg-1.
authors.affiliation: Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Jalan UMS, 88400, Kota Kinabalu, Sabah. r_ney84@Hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Sapaat
authors.forename: F
authors.initials: F
authors.lastname: Satrija
authors.forename: H H
authors.initials: HH
authors.lastname: Mahsol
authors.forename: A H
authors.initials: AH
authors.lastname: Ahmad
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000302:isolation & purification / Q000494:pharmacology; D029441:Carica / Q000737:chemistry*; D006925:Hymenolepiasis / Q000188:drug therapy*; D048190:Hymenolepis diminuta / Q000187:drug effects*; D008297:Male; D010270:Parasite Egg Count; D010936:Plant Extracts / Q000008:administration & dosage* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D010936:Plant Extracts