title: Analysis of the genetic effects of prolactin gene polymorphisms on chicken egg production.
abstract: Chicken prolactin (PRL) is a physiological candidate gene for egg production. Variations of T8052C and G8113C in exon 5 of PRL gene may associate with chicken egg production. The objective of the study was to investigate the association of these two single nucleotide polymorphisms in PRL gene with egg production of Recessive White chickens and Qingyuan Partridge chickens. Genotyping was performed by polymerase chain reaction-ligase detection reaction (PCR-LDR) method. The T8052C and G8113C of PRL were significantly associated with age at first egg (AFE) and total egg number at 300 days of age (EN 300). A significant association was also found between T8052C-G8113C haplotypes and AFE as well as EN300, the H2H3 was the most advantageous diplotype for egg production. We putatively drew the conclusion that these two SNPs in PRL gene as well as their haplotypes could be used as the potential molecular markers for egg production traits in chicken.
authors.affiliation: Institute of Poultry Science, Chinese Academy of Agricultural Science, Yangzhou 225125, Jiangsu, People's Republic of China. lhfxf@vip.qq.com
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Li
authors.forename: Jing-Ting
authors.initials: JT
authors.lastname: Shu
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Du
authors.forename: Yan-Ju
authors.initials: YJ
authors.lastname: Shan
authors.forename: Kuan-Wei
authors.initials: KW
authors.lastname: Chen
authors.forename: Xue-Yu
authors.initials: XY
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Xu
mesh_terms: D000483:Alleles; D000818:Animals; D002645:Chickens / Q000502:physiology*; D004531:Eggs; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011388:Prolactin / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D012098:Reproduction / Q000235:genetics
chemical_list: D011388:Prolactin