title: Assembly of a cohort of children treated for acute myeloid leukemia at free-standing children's hospitals in the United States using an administrative database.
abstract: Pediatric Health Information System data were used to establish a multi-center cohort of 1,686 children treated for newly diagnosed acute myeloid leukemia (AML). The cohort assembly process, which included myeloid leukemia ICD-9 discharge diagnosis codes and manual review of induction chemotherapy, was validated by chart review at a single institution. The use of ICD-9 codes alone resulted in a poor positive predictive value (PPV; 31%). Inclusion of the results from the chemotherapy review improved the PPV to 100% without compromising sensitivity (95.7%). This cohort provides a reliable source for future comparative effectiveness and clinical epidemiology studies in pediatric AML.
authors.affiliation: Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. kavicm@email.chop.edu
authors.forename: Marko
authors.initials: M
authors.lastname: Kavcic
authors.forename: Brian T
authors.initials: BT
authors.lastname: Fisher
authors.forename: Kari
authors.initials: K
authors.lastname: Torp
authors.forename: Yimei
authors.initials: Y
authors.lastname: Li
authors.forename: Yuan-Shung
authors.initials: YS
authors.lastname: Huang
authors.forename: Alix E
authors.initials: AE
authors.lastname: Seif
authors.forename: Marijana
authors.initials: M
authors.lastname: Vujkovic
authors.forename: Richard
authors.initials: R
authors.lastname: Aplenc
mesh_terms: D002648:Child; D015331:Cohort Studies; D016208:Databases, Factual; D063005:Health Information Systems / Q000458:organization & administration*; D006776:Hospitals, Pediatric; D006801:Humans; D038801:International Classification of Diseases; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D018426:SEER Program; D014481:United States