title: Remodeling a tissue: subtraction adds insight.
abstract: Sculpting a body plan requires both patterning of gene expression and translating that pattern into morphogenesis. Developmental biologists have made remarkable strides in understanding gene expression patterning, but despite a long history of fascination with the mechanics of morphogenesis, knowledge of how patterned gene expression drives the emergence of even simple shapes and forms has grown at a slower pace. The successful merging of approaches from cell biology, developmental biology, imaging, engineering, and mathematical and computational sciences is now accelerating progress toward a fuller and better integrated understanding of the forces shaping morphogenesis.
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. jaxelrod@stanford.edu
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Axelrod
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D004622:Embryo, Mammalian / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D006801:Humans; D008954:Models, Biological