title: Electrochemical immunosensor with graphene/gold nanoparticles platform and ferrocene derivatives label.
abstract: In the present work, sensitive and stable sandwiched electrochemical immunosensing strategies with graphene (Gr)/gold nanoparticles (GNP) composite as the immobilization platform and ferrocene (Fc) derivatives as labels were proposed. Under the optimal choice and the proposed immunosensing strategy, with 1,1'-ferrocenedicarboxylic acid label, the human IgG could be detected specifically with a low detection limit of 0.4 ng/mL and a wide linear dynamic range from 1 to 300 ng/mL. Meanwhile, the electrochemical behavior of three different ferrocene derivatives labels was studied.
authors.affiliation: College of Chemistry and Materials Science, Anhui Key Laboratory of Functional Molecular Solids, Anhui Key Laboratory of Chem-Biosensing, Anhui Normal University, Wuhu 241000, PR China. wangyuz@mail.ahnu.edu.cn
authors.forename: Guangfeng
authors.initials: G
authors.lastname: Wang
authors.forename: Xu
authors.initials: X
authors.lastname: Gang
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhou
authors.forename: Ge
authors.initials: G
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhang
authors.forename: Lun
authors.initials: L
authors.lastname: Wang
mesh_terms: D001565:Benzoates / Q000737:chemistry*; D015374:Biosensing Techniques; D055664:Electrochemical Techniques; D005296:Ferrous Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D000075163:Metallocenes
chemical_list: D001565:Benzoates; D005296:Ferrous Compounds; D007074:Immunoglobulin G; D000075163:Metallocenes; C517217:ferrocene dicarboxylic acid; D006046:Gold; D006108:Graphite