title: Numerical and experimental investigation of pulsatile hemodynamics in the total cavopulmonary connection.
abstract: Computational fluid dynamics (CFD) tools have been extensively applied to study the hemodynamics in the total cavopulmonary connection (TCPC) in patients with only a single functioning ventricle. Without the contraction of a sub-pulmonary ventricle, pulsatility of flow through this connection is low and variable across patients, which is usually neglected in most numerical modeling studies. Recent studies suggest that such pulsatility can be non-negligible and can be important in hemodynamic predictions. The goal of this work is to compare the results of an in-house numerical methodology for simulating pulsatile TCPC flow with experimental results. Digital particle image velocimetry (DPIV) was acquired on TCPC in vitro models to evaluate the capability of the CFD tool in predicting pulsatile TCPC flow fields. In vitro hemodynamic measurements were used to compare the numerical prediction of power loss across the connection. The results demonstrated the complexity of the pulsatile TCPC flow fields and the validity of the numerical approach in simulating pulsatile TCPC flow dynamics in both idealized and complex patient specific models.
authors.affiliation: School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, United States.
authors.forename: Elaine
authors.initials: E
authors.lastname: Tang
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Haggerty
authors.forename: Reza H
authors.initials: RH
authors.lastname: Khiabani
authors.forename: Diane
authors.initials: D
authors.lastname: de Zélicourt
authors.forename: Jessica
authors.initials: J
authors.lastname: Kanter
authors.forename: Fotis
authors.initials: F
authors.lastname: Sotiropoulos
authors.forename: Mark A
authors.initials: MA
authors.lastname: Fogel
authors.forename: Ajit P
authors.initials: AP
authors.lastname: Yoganathan
mesh_terms: D003198:Computer Simulation; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow