title: [Surgical prognostic factors of gastroenteropancreatic neuroendocrine tumors (GEP NET)].
abstract: OBJECTIVE
  to determine surgical prognostic variables from a retrospective cohort of histopathologically confirmed gastroenteropancreatic neuroendocrine tumors (GEP-NET) in Mexican subjects.
  
  
  METHODS
  consecutive patients treated for GEP-NET from 1999 through 2007 at Oncological Hospital were included. Demographic, clinical variables, disease-free survival were retrieved.
  
  
  RESULTS
  forty-eight patients were included, 29 (60.4 %) female with a mean age of 54 years. Overall survival time was 43.7 months and disease-free survival was 33 months. Negative statistically significant overall survival time predictors were 2 and 3 histological types (HR 5.5. CI 2.0-21, p = 0.0001), tumor size > 2 cm (HR 8.8, CI 1 .29-75, p = 0.002), the presence of metastasis (HR 2.4, CI 1.2-9.6, p = 0.0001) and tumor resectability (HR 9.8, CI 2.9-40.2, p = 0.0001). For the disease-free period, only the histological type (2 or 3) was a negative outcome variable.
  
  
  CONCLUSIONS
  histological type, tumor size, the presence of metastasis, and tumor non resectability were significant survival predictors.
authors.affiliation: Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México. drrmedrano@gmail.com
authors.forename: Rafael
authors.initials: R
authors.lastname: Medrano-Guzmán
authors.forename: Isabel
authors.initials: I
authors.lastname: Alvarado-Cabrero
authors.forename: Domingo
authors.initials: D
authors.lastname: González-Rodríguez
authors.forename: Sergio César
authors.initials: SC
authors.lastname: López-García
authors.forename: Francisco
authors.initials: F
authors.lastname: Páez-Agraz
mesh_terms: D005260:Female; D005770:Gastrointestinal Neoplasms / Q000401:mortality* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000401:mortality* / Q000601:surgery*; D018358:Neuroendocrine Tumors / Q000401:mortality* / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000401:mortality* / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies