title: Lessons from the heart and ischemic limbs: midkine as anti-inflammatory mediator for kidney diseases?
abstract: Inflammatory responses ensuing ischemia involve the release of numerous mediators. Among these the heparin-binding growth factor midkine has been recognized as a potent inducer of neoangiogenesis. In a recent publication, the release of midkine has been studied in different in vitro models, and effects of abrogated midkine expression by means of genetic knockout has been analyzed in ischemia models of the limbs. The observed effects indicate a profound effect exerted by midkine under ischemia in the coordination of the inflammatory response and neoangiogenesis.
authors.affiliation: Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke-University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.
authors.forename: Delia Lidia
authors.initials: DL
authors.lastname: Şalaru
authors.forename: Peter R
authors.initials: PR
authors.lastname: Mertens
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005121:Extremities / Q000098:blood supply*; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000150:complications; D007674:Kidney Diseases / Q000097:blood* / Q000209:etiology; D000078792:Midkine; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications; D009414:Nerve Growth Factors
chemical_list: D015415:Biomarkers; D016207:Cytokines; D009414:Nerve Growth Factors; D000078792:Midkine