title: [Association of the xeroderma pigmentosum group D DNA repair gene with hepatocellular carcinoma].
abstract: OBJECTIVE
  To explore the association between polymorphisms in the DNA repair gene, xeroderma pigmentosum group D (XPD), and development of hepatocellular carcinoma (HCC) in the Chinese population by performing a systematic review of the previously published clinical data.
  
  
  METHODS
  A comprehensive literature search of the BIOSIS Previews and PubMed databases was carried out to identify all case-control studies of XPD polymorphisms and HCC risk. Meta-analysis was conducted to calculate the pooled odds ratios (ORs) with 95% confidence intervals (CIs) of developing HCC for carriers of the various XPD polymorphisms.
  
  
  RESULTS
  Six case-control studies were selected for this meta-analysis, and comprised a total of 3424 HCC cases and 3636 controls. The pooled ORs (95% CIs) of XPD codon 751 and 312 allelomorphs were 1.25 (0.70 to 2.24) and 0.85 (0.58 to 1.25), respectively. Compared with the XPD wild-type homozygote Lys/Lys genotype of codon 751, the pooled OR (95% CI) of Lys/G1n + Gln/Gln genotypes for HCC risk was 1.31 (0.71 to 2.42). Compared with the XPD wild-type homozygote Asp/Asp genotype of codon 312, the pooled OR (95% CI) of Asp/Asn + Asn/Asn genotypes for HCC risk was 1.19 (0.73 to 1.95).
  
  
  CONCLUSIONS
  Polymorphisms in the XPD codons 751 and 312 are not associated with HCC risk in the Chinese population.
authors.affiliation: Department of Basic Medicine, China Medical University, Shenyang 110001, China.
authors.forename: Jia-ji
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Jian-zhong
authors.initials: JZ
authors.lastname: Ma
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D003062:Codon / Q000235:genetics; D004260:DNA Repair; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D003062:Codon; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human