title: An efficient synthesis of dopamine transporter tracer [¹⁸F]FECNT.
abstract: A simple synthesis of the dopamine transporter ligand [(18)F]FECNT with high radiochemical yield and short synthesis time, suitable for routine production is reported. Reaction of 2β-carbomethoxy-3β-(4-chlorophenyl)nortropane with [(18)F]2-fluoroethyl triflate ([(18)F]FEtOTf) at room temperature for 4 min provided [(18)F]FECNT in 84% decay corrected radiochemical yield. Since [(18)F]FEtOTf was prepared from [(18)F]2-fluoroethyl bromide that was isolated from its starting material, formation of unwanted side products and the amount of expensive precursor used could be greatly reduced. The overall radiochemical yields of [(18)F]FECNT were 40% (n=29) and the total synthesis time was ca. 100 min. The average specific activity of [(18)F]FECNT was 377.4 GBq/μmol (10.2 Ci/μmol).
authors.affiliation: Department of Medical Physics, University of Wisconsin-Madison, Madison, 1111 Highland Ave, 1005 WIMR, Madison, WI 53705, United States. dmurali@wisc.edu
authors.forename: D
authors.initials: D
authors.lastname: Murali
authors.forename: T E
authors.initials: TE
authors.lastname: Barnhart
authors.forename: N T
authors.initials: NT
authors.lastname: Vandehey
authors.forename: B T
authors.initials: BT
authors.lastname: Christian
authors.forename: R J
authors.initials: RJ
authors.lastname: Nickles
authors.forename: A K
authors.initials: AK
authors.lastname: Converse
authors.forename: J A
authors.initials: JA
authors.lastname: Larson
authors.forename: J E
authors.initials: JE
authors.lastname: Holden
authors.forename: M L
authors.initials: ML
authors.lastname: Schneider
authors.forename: O T
authors.initials: OT
authors.lastname: Dejesus
mesh_terms: D002851:Chromatography, High Pressure Liquid; D050483:Dopamine Plasma Membrane Transport Proteins / Q000032:analysis*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D009662:Nortropanes / Q000138:chemical synthesis*
chemical_list: C410211:2-carbomethoxy-3-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane; D050483:Dopamine Plasma Membrane Transport Proteins; D005462:Fluorine Radioisotopes; D009662:Nortropanes