title: Inhibitory effects of baeomycesic acid from the lichen Thamnolia subuliformis on 5-lipoxygenase in vitro.
abstract: Baeomycesic acid (1), a β-orcinol depside isolated from the lichen Thamnolia subuliformis (Ehrh.) W. Culb. was tested for in vitro inhibitory effects on arachidonate metabolism. Results showed that baeomycesic acid has potent dose-dependent inhibitory effects on 5-lipoxygenase isolated from porcine leucocytes, with an IC(50) value of 8.3 μM. Structure-activity relationships are discussed in comparison to other phenolic lichen constituents. Baeomycesic was inactive when tested for in vitro inhibitory effects against cyclooxygenase isolated from sheep seminal vesicle microsomes.
authors.affiliation: Dept. of Pharmacy, University of Iceland, Reykjavik, Iceland.
authors.forename: K
authors.initials: K
authors.lastname: Ingólfsdóttir
authors.forename: B
authors.initials: B
authors.lastname: Wiedemann
authors.forename: M
authors.initials: M
authors.lastname: Birgisdóttir
authors.forename: A
authors.initials: A
authors.lastname: Nenninger
authors.forename: S
authors.initials: S
authors.lastname: Jónsdóttir
authors.forename: H
authors.initials: H
authors.lastname: Wagner