title: Closed versus open endotracheal suctioning in extremely low-birth-weight neonates: a randomized, crossover trial.
abstract: BACKGROUND
  Endotracheal suctioning, which is frequently necessary in mechanically ventilated patients, might cause complications, especially in patients with compromised lung function such as extremely low-birth-weight (ELBW) neonates.
  
  
  OBJECTIVE
  To investigate whether closed endotracheal suctioning (CS) reduces the frequency of hypoxemia and bradycardia in ELBW neonates compared to open suctioning (OS).
  
  
  METHODS
  In a randomized, crossover trial, 15 ventilated ELBW neonates (mean birth weight 655 g) underwent suctioning with both techniques. Data on oxygen saturation (SpO2), heart rate (HR), arterial blood pressure, arterial blood gases, duration of the suctioning procedure and recovery time were collected. Statistical analysis was done using the SPSS t test for paired samples.
  
  
  RESULTS
  The mean frequency of hypoxemia <85% was significantly decreased (p = 0.012) during CS (0.5) versus OS (1.1). The mean minimum SpO2 was significantly higher (p = 0.012) during CS (87%) compared to OS (84%), and a significantly less steep drop in mean SpO2 (p = 0.007) (CS: -5%, OS: -8%) was found. Mean arterial PO2 (p = 0.035; CS: 59 mm Hg, OS: 53 mm Hg) and mean oxygenation ratio (p = 0.016; CS: 197, OS: 171) were significantly higher after CS. No significant differences were found in HR, incidence or duration of bradycardia, recovery time, arterial blood pressure, duration of suctioning, number of complications, or duration of hypoxemia.
  
  
  CONCLUSIONS
  CS was superior to OS on oxygenation values. To prove its overall superiority, further research is required. So, in this group of patients, CS should currently be administered on an individual basis.
authors.affiliation: Department of Pediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany. Pirr.Sabine@mh-hannover.de
authors.forename: Sabine M
authors.initials: SM
authors.lastname: Pirr
authors.forename: Matthias
authors.initials: M
authors.lastname: Lange
authors.forename: Carolin
authors.initials: C
authors.lastname: Hartmann
authors.forename: Bettina
authors.initials: B
authors.lastname: Bohnhorst
authors.forename: Corinna
authors.initials: C
authors.lastname: Peter
mesh_terms: D001724:Birth Weight; D001794:Blood Pressure; D001919:Bradycardia / Q000453:epidemiology / Q000209:etiology; D018592:Cross-Over Studies; D006339:Heart Rate; D006801:Humans; D000860:Hypoxia / Q000453:epidemiology / Q000209:etiology; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000601:surgery*; D010100:Oxygen / Q000097:blood; D012121:Respiration, Artificial; D013396:Suction / Q000009:adverse effects* / Q000379:methods*; D014132:Trachea / Q000601:surgery*
chemical_list: D010100:Oxygen