title: Galactose substituted zinc phthalocyanines as near infrared fluorescence probes for liver cancer imaging.
abstract: Galactose substituted with zinc phthalocyanines were synthesized and characterized as near infrared fluorescent probes. The probes have good water-solubility and high emission ability in the near infrared region. With nudemice bearing liver cancer as models, in vivo fluorescence imaging effects and organ distributions of probes show that zinc phthalocyanines with three or four galactose units have good cell biocompatibility in vitro and targeting effects for liver cancer imaging in vivo. These results show the potential of these near infrared optical probes in the diagnosis of cancer in future.
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Lv
authors.forename: Yanzhou
authors.initials: Y
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Cao
authors.forename: Tianjun
authors.initials: T
authors.lastname: Liu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D005456:Fluorescent Dyes / Q000737:chemistry; D005690:Galactose / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D054833:Isoindoles; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008819:Mice, Nude; D009942:Organometallic Compounds / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D017967:Zinc Compounds
chemical_list: D001672:Biocompatible Materials; D005456:Fluorescent Dyes; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D005690:Galactose