title: [Mechanisms responsible for the progression of scirrhous gastric cancer].
abstract: Scirrhous gastric carcinoma is characterized by rapid cancer cell infiltration and proliferation accompanied by extensive stromal fibrosis. The proliferative and invasive ability of scirrhous gastric cancer cells are closely associated with the growth factors, FGF7 and TGFbeta produced by organ-specific fibroblasts. Peritoneal fibroblasts morphologically change mesothelial cells, and stimulate the migratory capability of cancer cells. A FGFR2 phosphorylation inhibitor prolongs the survival of mice with peritoneal metastasis of scirrhous gastric cancer. A TGFbetaR inhibitor decreases the growth of fibroblast, and invasion-stimulating activity of fibroblasts on cancer cells. A FGFR2 phosphorylation inhibitor or TGFbetaR inhibitor appears therapeutically promising in scirrhous gastric carcinoma.
authors.affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yashiro
authors.forename: Masaichi
authors.initials: M
authors.lastname: Ohira
authors.forename: Kazuya
authors.initials: K
authors.lastname: Muguruma
authors.forename: Osamu
authors.initials: O
authors.lastname: Shinto
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000188:drug therapy / Q000473:pathology*; D000818:Animals; D018450:Disease Progression; D006801:Humans; D051379:Mice; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology*