title: Nephrotic syndrome after treatment of Crohn's disease with mesalamine: Case report and literature review.
abstract: Inflammatory bowel disease and its various treatments may affect the kidney in several ways. Recently, case reports have been published documenting the development of nephrotic syndrome after the treatment for inflammatory bowel disease with 5-aminosalicylic acid derivatives. We report a 50-year-old patient who was diagnosed with Crohn's disease and was treated with mesalamine. The patient subsequently developed nephrotic syndrome and a renal biopsy showed minimal change disease. He was treated with losartan and rosuvastatin and showed improvement in his renal function and serum cholesterol level. This is the first reported case in Crohn's disease although there have been six previous case reports of nephrotic syndrome following salicylic acid derivatives for ulcerative colitis.
authors.affiliation: Elmhurst Hospital Center, Mount Sinai School of Medicine, Elmhurst, NY, USA ; Department of Internal Medicine, University of Missouri, Columbia, MO, USA.
authors.forename: Belal M
authors.initials: BM
authors.lastname: Firwana
authors.forename: Rim
authors.initials: R
authors.lastname: Hasan
authors.forename: Walid
authors.initials: W
authors.lastname: Chalhoub
authors.forename: Mazen
authors.initials: M
authors.lastname: Ferwana
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Kang
authors.forename: Joshua
authors.initials: J
authors.lastname: Aron
authors.forename: Joseph
authors.initials: J
authors.lastname: Lieber