title: Muscle contraction mechanism based on single molecule measurements.
abstract: Single molecule measurements have shown that a muscle myosin step is driven by biased Brownian movement. Furthermore, they have also demonstrated that in response to strain in the backward direction a detached myosin head preferentially attaches to the forward direction due to an accelerated transition from a weak binding to strong binding state. Because they are consistent with the original Huxley model for muscle contraction, we have built a model that describes macroscopic muscle characteristics based on these single molecule results.
authors.affiliation: Graduate School of Frontier Biosciences, Osaka University, 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Yanagida
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Ishii
mesh_terms: D020527:Microscopy, Scanning Probe; D008958:Models, Molecular; D009119:Muscle Contraction; D009218:Myosins / Q000378:metabolism*
chemical_list: D009218:Myosins