title: Adhesion-preventing properties of 4% icodextrin and canola oil: a comparative experimental study.
abstract: OBJECTIVE
  Postsurgical abdominal adhesions are common, serious postoperative complications. The present study compared the usefulness of 4% icodextrin and canola oil in preventing postoperative peritoneal adhesions.
  
  
  METHODS
  Twenty-four Wistar albino rats were divided into three groups. Following a laparotomy, a serosal abrasion was made by brushing the cecum, and 3 mL of 0.9% NaCl, 4% icodextrin, or 3 mL of canola oil were intraperitoneally administered for the control, icodextrin, and canola oil groups, respectively. The abdomen was then closed. All of the rats were sacrificed at day 10. Macroscopic, histopathological, and biochemical evaluations were performed. The results were statistically analyzed using Kruskal-Wallis and ANOVA tests.
  
  
  RESULTS
  Macroscopic analyses revealed that both canola oil and 4% icodextrin reduced adhesion formation, but the difference was not statistically significant (p = 0.17). The histopathological examinations revealed no significant differences in terms of giant cell, lymphocyte/plasmocyte, neutrophil, ICAM1, or PECAM1 scores. However, both canola oil and 4% icodextrin significantly reduced fibrosis (p = 0.025). In the canola oil group, the histiocytic reactions were significantly increased (p = 0.001), and the hydroxyproline levels were significantly lower than those in the other groups (p = 0.034).
  
  
  CONCLUSIONS
  In the present study, canola oil was determined to be superior to 4% icodextrin in lowering hydroxyproline levels and increasing histiocytic reactions. Considering these results, we believe that canola oil is a promising agent for preventing adhesion formation.
authors.affiliation: Department of General Surgery, Gülhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey. cyigitler@hotmail.com
authors.forename: Cengizhan
authors.initials: C
authors.lastname: Yigitler
authors.forename: Dursun Ozgur
authors.initials: DO
authors.lastname: Karakas
authors.forename: Zafer
authors.initials: Z
authors.lastname: Kucukodaci
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Cosar
authors.forename: Bülent
authors.initials: B
authors.lastname: Gülec
authors.forename: Mehmet Levhi
authors.initials: ML
authors.lastname: Akin
mesh_terms: D000818:Animals; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use*; D005260:Female; D005936:Glucans / Q000627:therapeutic use*; D005947:Glucose / Q000627:therapeutic use*; D000077607:Icodextrin; D010532:Peritoneal Diseases / Q000517:prevention & control*; D010537:Peritoneum / Q000601:surgery*; D000074262:Rapeseed Oil; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D000267:Tissue Adhesions / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D005229:Fatty Acids, Monounsaturated; D005936:Glucans; D000074262:Rapeseed Oil; D000077607:Icodextrin; D005947:Glucose