title: [Pharmacogenetics: relevant aspects for the practicing veterinarian].
abstract: Pharmacogenetics is the study of genetic determinants of different responses to drug therapy and deals with differences in metabolic pathways and therapeutic effects as well as adverse reactions. A common genetic defect found in veterinary medicine is the MDR1 mutation occurring in Collies and related breeds that leads to an altered P-glycoprotein. Genetic mutations of enzymes (cytochrome P450, thiopurine s-methyltransferase, n-acetyltransferase, UDP-glucuronyltransferase, plasma esterase or sulfotransferase), which are responsible for the metabolism of drugs, are found as well. A decreased functional level of these enzymes can lead to an increased plasma concentration of the drug with a consequent relative overdose.
authors.affiliation: Institut für Veterinärpharmakologie und -toxikologie der Universität Zürich. rjud@vetclinics.uzh.ch
authors.forename: R
authors.initials: R
authors.lastname: Jud Schefer
authors.forename: C
authors.initials: C
authors.lastname: Paine Kuhn
authors.forename: D
authors.initials: D
authors.lastname: Demuth
mesh_terms: D000818:Animals; D004285:Dogs; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics / Q000517:prevention & control*; D010597:Pharmacogenetics / Q000379:methods* / Q000592:standards; D014730:Veterinary Medicine / Q000379:methods* / Q000592:standards