title: The anti-cancer activities of jasmonates.
abstract: Jasmonates, plant stress hormones protecting the plant from microbial pathogens and environmental stresses, were also discovered to have toxic activities toward mammalian cancer cells. Methyl jasmonate (MJ) was found to be the most active anti-cancer derivate among natural jasmonates, exhibiting a specific cell death-induction effect toward several cancer cells. Since that discovery of jasmonates-inducing cancer cell death, the molecular mechanism of action of jasmonates leading to cell death was deciphered. Moreover, in addition to the direct effects of MJ on cancer cell death, it was found to deregulate several genes and affect various intracellular factors and cellular processes, such as sensitization of apoptotic cell death induced by TRAIL, cancer cell migration attenuation, cell cycle arrest, and differentiation. This mini-review summarizes over a decade of research of jasmonates as anti-cancer agents.
authors.affiliation: Department of Clinical Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. zraviv06@gmail.com
authors.forename: Ziv
authors.initials: Z
authors.lastname: Raviv
authors.forename: Sharon
authors.initials: S
authors.lastname: Cohen
authors.forename: Dortit
authors.initials: D
authors.lastname: Reischer-Pelech
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D003517:Cyclopentanes / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D054883:Oxylipins / Q000494:pharmacology*; D010937:Plant Growth Regulators / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000494:pharmacology
chemical_list: D000085:Acetates; D000970:Antineoplastic Agents; D003517:Cyclopentanes; D054883:Oxylipins; D010937:Plant Growth Regulators; D017382:Reactive Oxygen Species; D053221:TNF-Related Apoptosis-Inducing Ligand; C072239:methyl jasmonate