title: Role of quercetin in vascular physiology.
abstract: A recent paper in the Canadian Journal of Physiology and Pharmacology has shown that quercetin has a vascular protective effect associated with eNOS up-regulation, blood GSH redox ratio, and reduction of oxidative stress. Recent reports have recommended the consumption of quercetin, as it may contribute to a reduction in the risk of cardiovascular disease. However, the mechanisms by which quercetin exerts its action have not been fully elucidated. The majority of these mechanisms have been identified with models using animals treated with quercetin, and relatively few have been corroborated in human studies, which indicates the need for further investigation.
authors.affiliation: Department of Medicine, Laboratorio Universitario di Ricerca, Medica (LURM)-Policlinico G.B. Rossi, University of Verona, Piazzale, Verona, Italy. salvatore.chirumbolo@univr.it
authors.forename: Salvatore
authors.initials: S
authors.lastname: Chirumbolo
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D002319:Cardiovascular System / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000097:blood / Q000235:genetics / Q000378:metabolism; D006801:Humans; D052250:Nitric Oxide Synthase Type III / Q000235:genetics / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000235:genetics; D011794:Quercetin / Q000494:pharmacology*; D015854:Up-Regulation
chemical_list: D011794:Quercetin; D052250:Nitric Oxide Synthase Type III; D005978:Glutathione