title: The contribution of thyroid dysfunction on cardiovascular disease in patients with chronic kidney disease.
abstract: Accelerated atherosclerosis and arterial stiffness are the two leading causes of increased cardiovascular disease in patients with chronic kidney disease. Dysfunctional thyroid hormone metabolism has been suggested to play a role in atherosclerosis and arterial stiffness. Changes in cardiac contractility and output, myocardial oxygen demand, systemic and peripheral vascular resistance, blood pressure and lipid profile, increased inflammatory burden and endothelial dysfunction may be responsible for thyroid hormone-related cardiovascular disease. This article focuses on the mechanistic insights of this association and provides a concise review of the current literature.
authors.affiliation: Ege University School of Medicine, Division on Nephrology, 35100 Bornova, Izmir, Turkey. etatar@hotmail.com
authors.forename: Erhan
authors.initials: E
authors.lastname: Tatar
authors.forename: Fatih
authors.initials: F
authors.lastname: Kircelli
authors.forename: Ercan
authors.initials: E
authors.lastname: Ok
mesh_terms: D050197:Atherosclerosis / Q000209:etiology; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology*; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D009200:Myocardial Contraction; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D013959:Thyroid Diseases / Q000150:complications* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000627:therapeutic use; D059289:Vascular Stiffness / Q000502:physiology
chemical_list: D013963:Thyroid Hormones