title: Relationship between plasminogen activator inhibitor type-1 (PAI-1) gene polymorphisms and osteoporosis in Turkish women.
abstract: OBJECTIVE
  The development of osteoporosis is associated with several risk factors, such as genetic structures that affect bone turnover and bone mass. The impact of genetic structures on osteoporosis is not known. Plasminogen activator inhibitor type-1 regulates the bone matrix and bone balance. This study assessed the correlation between plasminogen activator inhibitor type-1 gene 4G/5G polymorphisms and osteoporosis in a population of Turkish women.
  
  
  METHODS
  A total of 195 postmenopausal female patients who were diagnosed with osteoporosis (Group I) based on bone mineral density measurements via dual-energy x-ray absorptiometry and 90 females with no osteoporosis (Group II) were included in this study. Correlations between PAI-1 gene 4G/5G polymorphisms and osteoporosis were investigated through the identification of PAI-1 gene 4G/5G polymorphism genotypes using the polymerase chain reaction.
  
  
  RESULTS
  No significant differences in the genotype and allele frequency of 4G/5G plasminogen activator inhibitor type-1 polymorphisms were observed between the two groups, and both groups exhibited the most frequently observed 4G5G genotype.
  
  
  CONCLUSIONS
  No correlation between the development of osteoporosis in the female Turkish population and 4G/5G plasminogen activator inhibitor type-1 gene polymorphisms was observed.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Eskişehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Merih
authors.initials: M
authors.lastname: Ozgen
authors.forename: Didem Turgut
authors.initials: DT
authors.lastname: Cosan
authors.forename: Fulya
authors.initials: F
authors.lastname: Doganer
authors.forename: Ahu
authors.initials: A
authors.lastname: Soyocak
authors.forename: Onur
authors.initials: O
authors.lastname: Armagan
authors.forename: Hasan Veysi
authors.initials: HV
authors.lastname: Gunes
authors.forename: Irfan
authors.initials: I
authors.lastname: Degirmenci
authors.forename: Gulsah Ogutler
authors.initials: GO
authors.lastname: Ozkara
authors.forename: Fezan Sahin
authors.initials: FS
authors.lastname: Mutlu
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density / Q000502:physiology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D018709:Statistics, Nonparametric; D014421:Turkey
chemical_list: D017395:Plasminogen Activator Inhibitor 1