title: The role of Src kinase in macrophage-mediated inflammatory responses.
abstract: Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation. Many studies have shown that Src plays multiple roles in macrophage-mediated innate immunity, such as phagocytosis, the production of inflammatory cytokines/mediators, and the induction of cellular migration, which strongly implies that Src plays a pivotal role in the functional activation of macrophages. Macrophages are involved in a variety of immune responses and in inflammatory diseases including rheumatoid arthritis, atherosclerosis, diabetes, obesity, cancer, and osteoporosis. Previous studies have suggested roles for Src in macrophage-mediated inflammatory responses; however, recently, new functions for Src have been reported, implying that Src functions in macrophage-mediated inflammatory responses that have not been described. In this paper, we discuss recent studies regarding a number of these newly defined functions of Src in macrophage-mediated inflammatory responses. Moreover, we discuss the feasibility of Src as a target for the development of new pharmaceutical drugs to treat macrophage-mediated inflammatory diseases. We provide insights into recent reports regarding new functions for Src that are related to macrophage-related inflammatory responses and the development of novel Src inhibitors with strong immunosuppressive and anti-inflammatory properties, which could be applied to various macrophage-mediated inflammatory diseases.
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University, Suwon 446-746, Republic of Korea.
authors.forename: Se Eun
authors.initials: SE
authors.lastname: Byeon
authors.forename: Young-Su
authors.initials: YS
authors.lastname: Yi
authors.forename: Jueun
authors.initials: J
authors.lastname: Oh
authors.forename: Byong Chul
authors.initials: BC
authors.lastname: Yoo
authors.forename: Sungyoul
authors.initials: S
authors.lastname: Hong
authors.forename: Jae Youl
authors.initials: JY
authors.lastname: Cho
mesh_terms: D000818:Animals; D051547:Heme Oxygenase-1 / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007728:Kupffer Cells / Q000502:physiology; D008264:Macrophages / Q000502:physiology*; D019255:NADPH Oxidases / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000502:physiology; D019061:src-Family Kinases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*
chemical_list: D017382:Reactive Oxygen Species; D051193:Toll-Like Receptors; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1; D019255:NADPH Oxidases; D019061:src-Family Kinases