title: Catalytic diastereo- and enantioselective annulations between transient nitrosoalkenes and indoles.
abstract: Caught in transition: an efficient catalytic system is the key to the successful development of the first highly diastereo- and enantioselective annulation reaction between indoles and transient nitrosoalkenes. This robust reaction affords structurally unique architectures with up to three new chiral centers. The products can be readily elaborated into other indoline-based chiral heterocyclic motifs, including those of pyrrolidinoindoline alkaloids.
authors.affiliation: Department of Chemistry, The University of Texas at San Antonio, 78249, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: David
authors.initials: D
authors.lastname: Stephens
authors.forename: Graciela
authors.initials: G
authors.lastname: Hernandez
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Mendoza
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Larionov
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009603:Nitroso Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D006571:Heterocyclic Compounds; D007211:Indoles; D009603:Nitroso Compounds; D003300:Copper