title: Association of common WRAP 53 variant with ovarian cancer risk in the Polish population.
abstract: Among many alterations within the TP53 gene the rs1042522 (C72G, p.Pro72Arg) has been associated with numerous cancers , however the results differ between populations for opposite Pro or Arg alleles. Similar thus inconclusive results are observed in ovarian cancer, which may suggest that the rs1042522 does not influence ovarian carcinogenesis directly, but might be linked to another pathogenic alteration. WRAP53 which overlaps the TP53 is required to maintain normal levels of p53 upon DNA damage, but also when altered may independently increase the risk of cancer. To evaluate the association between three SNPs located in WRAP53-TP53 region: rs1042522, rs2287497, rs2287498 and ovarian cancer risk in Polish population we genotyped 626 cases and 1,045 healthy controls. Our results provide the evidence for an association between studied SNPs and a risk of invasive ovarian cancer in Poland. We found that CC homozygotes in rs1042522 were more frequent in cancers when compared to controls (OR = 1.46, p = 0.03). Similarly in WRAP53 both TT homozygotes in rs2287497 (OR = 1.95, p = 0.03) and AA homozygotes in rs2287498 (OR = 2.65, p = 0,01) were more frequent among cases than healthy individuals. There is also a suggestive evidence that specific homozygosity of studied SNPs in TP53-WRAP53 region is significantly overrepresented in ovarian cancer patients. In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian cancer risk than rs1042522 in TP53.
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. kris.medrek@gmail.com
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Mędrek
authors.forename: Piotr
authors.initials: P
authors.lastname: Magnowski
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Masojć
authors.forename: Anita
authors.initials: A
authors.lastname: Chudecka-Głaz
authors.forename: Bogdan
authors.initials: B
authors.lastname: Torbe
authors.forename: Janusz
authors.initials: J
authors.lastname: Menkiszak
authors.forename: Marek
authors.initials: M
authors.lastname: Spaczyński
authors.forename: Jacek
authors.initials: J
authors.lastname: Gronwald
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
authors.forename: Bohdan
authors.initials: B
authors.lastname: Górski
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D018832:Molecular Chaperones; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000235:genetics*; D011044:Poland; D012306:Risk; D019098:Telomerase / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D018832:Molecular Chaperones; D016159:Tumor Suppressor Protein p53; D019098:Telomerase; C535133:WRAP53 protein, human