title: Ranolazine maintained sinus rhythm in a patient with refractory symptomatic atrial fibrillation.
abstract: We report on a patient who was treated with several antiarrhythmic drugs as well as different ablation strategies. Nevertheless, symptomatic atrial fibrillation always recurred until an off-label use with ranolazine was started. We could demonstrate potent effects of ranolazine on atrial fibrillation in a "wash-in wash-out" situation. Although promising controlled studies are needed to investigate a potential role of ranolazine for the treatment of atrial fibrillation.
authors.affiliation: Department of Cardiology and Pneumology/Heart Center Göttingen, Georg-August-University Göttingen, Göttingen, Germany.
authors.forename: Samuel
authors.initials: S
authors.lastname: Sossalla
authors.forename: Christian
authors.initials: C
authors.lastname: Sohns
authors.forename: Joachim
authors.initials: J
authors.lastname: Seegers
authors.forename: Lars
authors.initials: L
authors.lastname: Lüthje
authors.forename: Dirk
authors.initials: D
authors.lastname: Vollmann
authors.forename: Markus
authors.initials: M
authors.lastname: Zabel
mesh_terms: D000083:Acetanilides / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D000069458:Ranolazine
chemical_list: D000083:Acetanilides; D000889:Anti-Arrhythmia Agents; D010879:Piperazines; D000069458:Ranolazine