title: Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis.
abstract: OBJECTIVE
  This study assessed the potential of topical Calendula officinalis extract on the healing of oral mucositis induced by 5-fluorouracil (5-FU) in hamsters.
  
  
  METHODS
  Oral mucositis was induced in 60 male hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on days 1 and 2. On days 12-17, 5% and 10% C. officinalis gel and gel base groups were treated and then compared with a control group. Macroscopic and microscopic scores and weights were evaluated.
  
  
  RESULTS
  Microscopic and macroscopic scores of mucositis were lower in the 5% and 10% C. officinalis gel groups than in the gel base and control groups (P < .05). Weight gain was noted in the treatment groups compared with the gel base and control groups (P < .05).
  
  
  CONCLUSIONS
  Calendula officinalis extract accelerated the healing of oral mucositis in hamsters.
authors.affiliation: Stem Cell and Transgenic Technology Research Center and Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Nader
authors.initials: N
authors.lastname: Tanideh
authors.forename: Parisa
authors.initials: P
authors.lastname: Tavakoli
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Saghiri
authors.forename: Franklin
authors.initials: F
authors.lastname: Garcia-Godoy
authors.forename: Dariush
authors.initials: D
authors.lastname: Amanat
authors.forename: Azadeh Andisheh
authors.initials: AA
authors.lastname: Tadbir
authors.forename: Soleiman Mohammadi
authors.initials: SM
authors.lastname: Samani
authors.forename: Amin
authors.initials: A
authors.lastname: Tamadon
mesh_terms: D000038:Abscess / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D020838:Calendula; D002266:Carboxymethylcellulose Sodium; D006224:Cricetinae; D004337:Drug Carriers; D004890:Erythema / Q000139:chemically induced / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D005782:Gels; D006940:Hyperemia / Q000139:chemically induced / Q000473:pathology; D007274:Injections, Intraperitoneal; D008297:Male; D008647:Mesocricetus; D009059:Mouth Diseases / Q000139:chemically induced / Q000473:pathology; D009061:Mouth Mucosa / Q000187:drug effects / Q000293:injuries / Q000473:pathology; D006472:Oral Hemorrhage / Q000139:chemically induced / Q000473:pathology; D019226:Oral Ulcer / Q000139:chemically induced / Q000473:pathology; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use*; D062326:Re-Epithelialization / Q000187:drug effects; D016037:Single-Blind Method; D013280:Stomatitis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors; D015430:Weight Gain; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000964:Antimetabolites, Antineoplastic; D004337:Drug Carriers; D005782:Gels; D010936:Plant Extracts; D002266:Carboxymethylcellulose Sodium; D005472:Fluorouracil