title: Anticomplementary flavonoids from Galphimia glauca.
abstract: In continuation of pharmacological investigations on polyphenolic compounds from the aerial parts of Galphimia glauca, flavonol acyl glycosides and gallic acid derivatives were screened in the classical and alternative complement assay. A reduction of complement-induced hemolysis was measured for quercetin-3-O-(2″-galloyl)-β-D-glucoside by 91.3 ± 1.76% (100 μM) and by 76.69 ± 4.43% (50 μM), respectively, and for quercetin-3-O-(6″-galloyl)-β-D-glucoside by 74.3 ± 6.77% (50 μM). Isoquercitrin, hyperoside, gallic acid, and ellagic acid inhibited the hemolysis to a much lower extent. In the alternative pathway quercetin-3-O-(2″-galloyl)-β-D-glucoside and quercetin-3-O-(2″-galloyl)-β-D-glucoside exhibited weaker inhibitory effects than in the classical pathway.
authors.affiliation: Institute of Pharmaceutical Biology, Ludwig Maximilians University, Munich, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Müller
authors.forename: S
authors.initials: S
authors.lastname: Reiter
authors.forename: C
authors.initials: C
authors.lastname: Wirth
authors.forename: H
authors.initials: H
authors.lastname: Wagner