title: Association between celiac disease and primary lactase deficiency.
abstract: Primary lactase deficiency (PLD) is a common inherited condition caused by a reduced activity of lactase. Two single-nucleotide polymorphisms C/T(-13910) and G/A(-22018) upstream of the lactase gene are associated with lactase nonpersistence. In celiac disease (CD) patients, lactose intolerance could be due to secondary lactase deficiency and to PLD. The aim of this study were to evaluate the association of PLD and CD using genetic test, and to define the prevalence of PLD in celiac subjects compared with a control population. A total of 188 controls and 92 biopsy-proven CD patients were included in the study. More than 70% of all subjects were found homozygous for the polymorphisms. Differences in the prevalence of PLD were not found between CD patients and controls.In conclusions, the hereditary lactase deficiency is frequent in Italian CD children as in control population.
authors.affiliation: Hepatology, Gastroenterology and Nutrition Unit, Pediatric Hospital Bambino Gesu' Rome, Italy. msole.basso@opbg.net
authors.forename: M S
authors.initials: MS
authors.lastname: Basso
authors.forename: R
authors.initials: R
authors.lastname: Luciano
authors.forename: F
authors.initials: F
authors.lastname: Ferretti
authors.forename: M
authors.initials: M
authors.lastname: Muraca
authors.forename: F
authors.initials: F
authors.lastname: Panetta
authors.forename: F
authors.initials: F
authors.lastname: Bracci
authors.forename: S
authors.initials: S
authors.lastname: Ottino
authors.forename: A
authors.initials: A
authors.lastname: Diamanti
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003677:Deficiency Diseases / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D005260:Female; D006720:Homozygote; D006801:Humans; D007558:Italy / Q000453:epidemiology; D043322:Lactase / Q000172:deficiency* / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence
chemical_list: D043322:Lactase