title: Acantholytic pityriasis rubra pilaris associated with imiquimod 3.75% application.
abstract: Imiquimod is an immunomodulator with both antitumor and antiviral properties. It is currently available in two cream formulations as Aldara (imiquimod 5%) and the newly approved Zyclara (imiquimod 3.75%). Imiquimod has been associated with localized erythema, crusting, and scaling at the site of application. However, more severe generalized skin eruptions including erythema multiforme, psoriasis, and hyperpigmentation have been described. The newly approved imiquimod 3.75% cream is a presumably safer alternative due to its lower concentration. This paper describes the development of generalized acantholytic pityriasis rubra pilaris after the treatment of an actinic keratosis on the forehead with imiquimod 3.75% cream.
authors.affiliation: Department of Dermatology, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Natasha
authors.initials: N
authors.lastname: Atanaskova Mesinkovska
authors.forename: Danyelle
authors.initials: D
authors.lastname: Dawes
authors.forename: Apra
authors.initials: A
authors.lastname: Sood
authors.forename: Wilma
authors.initials: W
authors.lastname: Bergfeld