title: Expansion of hematopoietic stem cells for transplantation: current perspectives.
abstract: Hematopoietic stem cells (HSCs) are rare cells that have the unique ability to self-renew and differentiate into cells of all hematopoietic lineages. The expansion of HSCs has remained an important goal to develop advanced cell therapies for bone marrow transplantation and many blood disorders. Over the last several decades, there have been numerous attempts to expand HSCs in vitro using purified growth factors that are known to regulate HSCs. However, these attempts have been met with limited success for clinical applications. New developments in the HSC expansion field coupled with gene therapy and stem cell transplant should encourage progression in attractive treatment options for many disorders including hematologic conditions, immunodeficiencies, and genetic disorders.
authors.affiliation: Department of Pathology, The State University of New York at Stony Brook, Stony Brook, NY, 11794, USA. jerell.aguila@stonybrook.edu.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Schuster
authors.forename: Maria R
authors.initials: MR
authors.lastname: Stupnikov
authors.forename: Gina
authors.initials: G
authors.lastname: Ma
authors.forename: Wenbin
authors.initials: W
authors.lastname: Liao
authors.forename: Raymond
authors.initials: R
authors.lastname: Lai
authors.forename: Yupo
authors.initials: Y
authors.lastname: Ma
authors.forename: Jerell R
authors.initials: JR
authors.lastname: Aguila