title: Sensation-seeking genes and physical activity in youth.
abstract: Many studies examining genetic influences on physical activity (PA) have evaluated the impact of single nucleotide polymorphisms (SNPs) related to the development of lifestyle-related chronic diseases, under the hypothesis that they would be associated with PA. However, PA is a multidetermined behavior and associated with a multitude of health consequences. Thus, examining a broader range of candidate genes associated with a broader range of PA correlates may provide new insights into the genetic underpinnings of PA. In this study, we focus on one such correlate - sensation-seeking behavior. Participants (N = 1130 Mexican origin youth) provided a saliva sample and data on PA and sensation-seeking tendencies in 2008-2009. Participants were genotyped for 630 functional and tagging variants in the dopamine, serotonin and cannabinoid pathways. Overall 30% of participants (males - 37.6% and females - 22.0%) reported ≥60 min of PA on 5 of 7 days. After adjusting for gender, age and population stratification, and applying the Bayesian False Discovery Probability approach for assessing noteworthiness, four gene variants were significantly associated with PA. In a multivariable model, being male, having higher sensation-seeking tendencies and at least one copy of the minor allele for SNPs in angiotensin I-converting enzyme gene [ACE; rs8066276 odds ratio (OR) = 1.44; P = 0.012] and tryptophan hydroxylase 2 gene (TPH2; rs11615016 OR = 1.73; P = 0.021) were associated with increased likelihood of meeting PA recommendations. Participants with at least one copy of the minor allele for SNPs in synaptosomal-associated protein 25 gene (SNAP25; rs363035 OR = 0.53; P = 0.005) and cannabinoid receptor 1 gene (CNR1; rs6454672 OR = 0.62; P = 0.022) have decreased likelihood of meeting PA recommendations. Our findings extend current knowledge of the complex relationship between PA and possible genetic underpinnings.
authors.affiliation: Division of Epidemiology, Human Genetics and Environmental Science, University of Texas School of Public Health, Austin Regional Campus, Austin, TX 78701, USA. Anna.V.Wilkinson@uth.tmc.edu
authors.forename: A V
authors.initials: AV
authors.lastname: Wilkinson
authors.forename: K P
authors.initials: KP
authors.lastname: Gabriel
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: M L
authors.initials: ML
authors.lastname: Bondy
authors.forename: Q
authors.initials: Q
authors.lastname: Dong
authors.forename: X
authors.initials: X
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Shete
authors.forename: M R
authors.initials: MR
authors.lastname: Spitz
mesh_terms: D000293:Adolescent; D000483:Alleles; D001499:Bayes Theorem; D016022:Case-Control Studies; D015331:Cohort Studies; D058999:Drug-Seeking Behavior; D015444:Exercise; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D017058:Mexican Americans / Q000235:genetics; D009043:Motor Activity / Q000235:genetics*; D015999:Multivariate Analysis; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics; D012677:Sensation / Q000235:genetics*; D012907:Smoking / Q000523:psychology; D050825:Synaptosomal-Associated Protein 25 / Q000235:genetics; D014365:Tryptophan Hydroxylase / Q000235:genetics
chemical_list: C571130:CNR1 protein, human; D043884:Receptor, Cannabinoid, CB1; C494208:SNAP25 protein, human; D050825:Synaptosomal-Associated Protein 25; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A