title: Toxicopathological evaluation in Wistar rats (Rattus norvegicus) following repeated oral exposure to acephate.
abstract: The present study was carried out to evaluate the effects of exposure at different doses of acephate on hematology, blood biochemistry, oxidative stress and immune system of Wistar rats. The experiment was carried out on 40 Wistar rats, which were divided in four groups. Animals of the three treatment groups were given with different sublethal doses (1/40th, 1/20th, 1/10th of lethal dose 50 value) of acephate by oral gavage. The hematology, blood biochemistry, oxidative stress marker, humoral immune response and cell-mediated immunity were evaluated following acephate exposure. Significant alteration in hematological parameters was not observed following different doses of acephate; however, significant alteration in alkaline phosphatase, gamma glutamyl transferase, acetyl cholinesterase, lipid peroxidase and superoxide dismutase was observed in medium- and high-dose group animals. Nonsignificant decrease in antibody titer in animals exposed to high dose has been observed compared with animals of control group. However, significant alteration in cell-mediated immunity was not observed in animals treated with acephate at different doses.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science & A.H., Junagadh Agricultural University, Junagadh, Gujarat, India arbhadaniya@yahoo.co.in.
authors.forename: Amit R
authors.initials: AR
authors.lastname: Bhadaniya
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science & A.H., Junagadh Agricultural University, Junagadh, Gujarat, India.
authors.forename: Vinay A
authors.initials: VA
authors.lastname: Kalariya
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science & A.H., Sardarkrushinagar Dantiwada Agricultural University, Dantiwada, Gujarat, India.
authors.forename: Dilip V
authors.initials: DV
authors.lastname: Joshi
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science & A.H., Sardarkrushinagar Dantiwada Agricultural University, Dantiwada, Gujarat, India.
authors.forename: Bakor J
authors.initials: BJ
authors.lastname: Patel
authors.affiliation: Department of Veterinary Physiology, College of Veterinary Science & A.H., Sardarkrushinagar Dantiwada Agricultural University, Dantiwada, Gujarat, India.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Chaudhary
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science & A.H., Sardarkrushinagar Dantiwada Agricultural University, Dantiwada, Gujarat, India.
authors.forename: Hitesh B
authors.initials: HB
authors.lastname: Patel
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science & A.H., Navsari Agricultural University, Navsari, Gujarat, India.
authors.forename: Jignesh M
authors.initials: JM
authors.lastname: Patel
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science & A.H., Junagadh Agricultural University, Junagadh, Gujarat, India.
authors.forename: Urvesh D
authors.initials: UD
authors.lastname: Patel
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science & A.H., Junagadh Agricultural University, Junagadh, Gujarat, India.
authors.forename: Harshad B
authors.initials: HB
authors.lastname: Patel
authors.affiliation: Cattle Breeding Farm, Junagadh Agricultural University, Junagadh, Gujarat, India.
authors.forename: Sanjay N
authors.initials: SN
authors.lastname: Ghodasara
authors.affiliation: Department of Animal Nutrition, College of Veterinary Science & A.H., Junagadh Agricultural University, Junagadh, Gujarat, India.
authors.forename: Harish H
authors.initials: HH
authors.lastname: Savsani
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001774:Blood Chemical Analysis; D005260:Female; D007109:Immunity / Q000187:drug effects; D008297:Male; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000633:toxicity*; D063088:Phosphoramides / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D059550:Toxicity Tests, Subchronic
chemical_list: D009946:Organothiophosphorus Compounds; D063088:Phosphoramides; C001969:acephate