title: Convenient method for the synthesis of a flexible cyclic polyamide for selective targeting of c-myb G-quadruplex DNA.
abstract: A convenient efficient method for synthesis of a flexible cyclic polyamide (cβ, 1) was developed through cyclodimerization. Electrospray ionization mass spectrometry and nuclear magnetic resonance results showed that 1 selectively binds to the c-myb G-quadruplex with high affinity, and there was no binding with the ILPR, bcl-2, and c-kit G-quadruplexes. This is the first time that a flexible cyclic polyamide was found to have high selectivity for the c-myb G-quadruplex.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Cui
authors.forename: Sen
authors.initials: S
authors.lastname: Lin
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhou
authors.forename: Gu
authors.initials: G
authors.lastname: Yuan
mesh_terms: D054856:G-Quadruplexes; D020570:Genes, myb / Q000187:drug effects*; D007328:Insulin / Q000235:genetics; D015394:Molecular Structure; D009757:Nylons / Q000138:chemical synthesis* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
chemical_list: D007328:Insulin; D009757:Nylons