title: [The transition of deep brain stimulation from disease specific to symptom specific indications].
abstract: The success of chronic deep brain stimulation (DBS) and electrical neuro-network modulation (ENM) to address neurological and neuropsychiatric disorders has led the Food and Drug Administration (FDA), and also other worldwide regulatory agencies to grant approval for the use of DBS in specific disorders. In the United States, DBS is FDA approved for the treatment of advanced Parkinson's disease (PD), essential tremor (ET), obsessive compulsive disorder (OCD), and for dystonia. OCD and dystonia have been approved under a mechanism referred to as a humanitarian device exemption (HDE). However, as the field of DBS and ENM evolve there has been a shift in practice patterns from targeting diseases to targeting specific and disabling symptoms. This shift has been driving interdisciplinary DBS boards to collect, and to address symptom profiles in all potential DBS candidates. Based on a specific symptom profile, a strategic and personalized medicine approach can be undertaken. The personalized approach will take into consideration the brain target, a unilateral versus a bilateral procedure, and the potential for use of more than one DBS lead per brain hemisphere. Additionally, a personalized approach to DBS will also facilitate improved pre-operative medication adjustments, as well as optimal post-operative medication, behavioral, and device management.
authors.affiliation: University of Florida Center for Movement Disorders & Neurorestoration, Gainesville, FL 32607, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
mesh_terms: D046690:Deep Brain Stimulation; D006801:Humans; D001523:Mental Disorders / Q000628:therapy*; D009422:Nervous System Diseases / Q000628:therapy*; D057285:Precision Medicine