title: Protein-tyrosine kinase signaling in the biological functions associated with sperm.
abstract: In sexual reproduction, two gamete cells (i.e., egg and sperm) fuse (fertilization) to create a newborn with a genetic identity distinct from those of the parents. In the course of these developmental processes, a variety of signal transduction events occur simultaneously in each of the two gametes, as well as in the fertilized egg/zygote/early embryo. In particular, a growing body of knowledge suggests that the tyrosine kinase Src and/or other protein-tyrosine kinases are important elements that facilitate successful implementation of the aforementioned processes in many animal species. In this paper, we summarize recent findings on the roles of protein-tyrosine phosphorylation in many sperm-related processes (from spermatogenesis to epididymal maturation, capacitation, acrosomal exocytosis, and fertilization).
authors.affiliation: Laboratory of Cell Signaling and Development, Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan.
authors.forename: Takashi W
authors.initials: TW
authors.lastname: Ijiri
authors.forename: A K M
authors.initials: AK
authors.lastname: Mahbub Hasan
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Sato