title: Maternal serum tumour necrosis factor receptor 1 (TNF-R1) at 30-33 weeks in the prediction of preeclampsia.
abstract: OBJECTIVE
  To investigate the potential value of maternal serum concentration of tumour necrosis factor receptor 1 (TNF-R1) at 30-33 weeks' gestation in the prediction of preeclampsia (PE) developing at or after 34 weeks.
  
  
  METHODS
  Serum TNF-R1 was measured at 11-13 and at 30-33 weeks' gestation in a case-control study of 50 cases that developed PE at or after 34 weeks and 250 unaffected controls. The measured values of TNF-R1 were converted into multiples of the normal median (MoM) and the MoM values in the PE and control groups were compared.
  
  
  RESULTS
  The median MoM TNF-R1 was significantly increased at both 11-13 weeks (1.094 MoM versus 1.003 MoM) and at 30-33 weeks (1.101 MoM versus 1.006 MoM). In screening for PE by a combination of maternal characteristics and serum TNF-R1 at 30-33 weeks, the estimated detection rates of PE at false positive rates of 5% and 10% were 32.0% and 40.0%, respectively.
  
  
  CONCLUSIONS
  Screening by maternal characteristics and serum TNF-R1 at 30-33 weeks could be effective in identifying some of the cases that will subsequently develop PE.
authors.affiliation: Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, UK.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Mosimann
authors.forename: Marion
authors.initials: M
authors.lastname: Wagner
authors.forename: Cahit
authors.initials: C
authors.lastname: Birdir
authors.forename: Leona C Y
authors.initials: LC
authors.lastname: Poon
authors.forename: Kypros H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; D047888:Receptors, Tumor Necrosis Factor, Type I