title: Translational control by 3'-UTR-binding proteins.
abstract: The regulation of mRNA translation is a major checkpoint in the flux of information from the transcriptome to the proteome. Critical for translational control are the trans-acting factors, RNA-binding proteins (RBPs) and small RNAs that bind to the mRNA and modify its translatability. This review summarizes the mechanisms by which RBPs regulate mRNA translation, with special focus on those binding to the 3'-untranslated region. It also discusses how recent high-throughput technologies are revealing exquisite layers of complexity and are helping to untangle translational regulation at a genome-wide scale.
authors.affiliation: Centre for Genomic Regulation (CRG) and UPF, Gene Regulation, Stem Cells and Cancer Programme, Dr. Aiguader 88, 08003-Barcelona, Spain.
authors.forename: Emilia
authors.initials: E
authors.lastname: Szostak
authors.forename: Fátima
authors.initials: F
authors.lastname: Gebauer
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D000818:Animals; D023281:Genomics; D006801:Humans; D008954:Models, Biological; D014176:Protein Biosynthesis / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D020413:3' Untranslated Regions; D016601:RNA-Binding Proteins