title: The miRNAs of herpes simplex virus (HSV).
abstract: Herpes simplex virus (HSV) is a group of common human pathogens with two serotypes HSV-1 and HSV-2. The prevalence of HSV is worldwide. It primarily infects humans through epithelial cells, when it introduces a latent infection into the nervous system. During viral latency, only a region known as the latency-associated transcript (LAT) is expressed. The discovery of HSV miRNAs helps to draw a larger picture of the infection and pathogenesis of the virus. This review summarizes miRNAs found in HSV-1 and HSV-2 so far. The functional studies of miRNAs in HSV to date indicate that they play a stage-specific role coordinated with viral proteins to maintain the virus life cycle.
authors.affiliation: Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming 650118, China.
authors.forename: Le
authors.initials: L
authors.lastname: Sun
authors.forename: Qihan
authors.initials: Q
authors.lastname: Li
mesh_terms: D015967:Gene Expression Regulation, Viral; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics* / Q000378:metabolism*; D018139:Simplexvirus / Q000235:genetics* / Q000502:physiology; D017735:Virus Latency; D014779:Virus Replication
chemical_list: D035683:MicroRNAs; D012367:RNA, Viral