title: Application of the VSRAD, a specific and sensitive voxel-based morphometry, to comparison of entorhinal cortex atrophy between dementia with Lewy bodies and Alzheimer's disease.
abstract: BACKGROUND
  Previous studies using magnetic resonance imaging (MRI) showed that dementia with Lewy bodies (DLB) had less atrophy in some medial temporal structures than Alzheimer's disease (AD). However, very few studies have focused on the entorhinal cortex, which is closely related to episodic memory. We compared the degree of entorhinal cortex atrophy between the two types of dementia using the voxel-based specific regional analysis system for AD (VSRAD) targeting this region.
  
  
  METHODS
  The subjects consisted of 60 patients with DLB and 210 patients with AD. The degree of entorhinal cortex atrophy was quantified by application of the VSRAD to MRI data, and a Z score >2 was defined as significant atrophy.
  
  
  RESULTS
  The DLB group had significantly lower Z scores than the AD group (mean ± SD: 2.25 ± 1.10 vs. 2.85 ± 1.33, p < 0.01). The analysis of covariance with possible confounding factors as covariates also showed that Z scores were significantly lower in the DLB group than in the AD group (p < 0.01). The proportion of patients with atrophy was significantly lower in the DLB group than in the AD group (53 vs. 72%, p < 0.01).
  
  
  CONCLUSIONS
  The present study using the VSRAD suggests that DLB shows less atrophy in the entorhinal cortex than AD.
authors.affiliation: Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan. hhayashi@med.id.yamagata-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hayashi
authors.forename: Shinobu
authors.initials: S
authors.lastname: Kawakatsu
authors.forename: Akihito
authors.initials: A
authors.lastname: Suzuki
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Shibuya
authors.forename: Ryota
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Chikako
authors.initials: C
authors.lastname: Sato
authors.forename: Koichi
authors.initials: K
authors.lastname: Otani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy / Q000473:pathology*; D001284:Atrophy; D003627:Data Interpretation, Statistical; D000077265:Donepezil; D018728:Entorhinal Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007189:Indans / Q000627:therapeutic use; D020961:Lewy Body Disease / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D018697:Nootropic Agents / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D012727:Sex Characteristics
chemical_list: D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil