title: Concise review: adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical implications for tissue engineering therapies in regenerative surgery.
abstract: Cell-based therapy and regenerative medicine offer a paradigm shift in regard to various diseases causing loss of substance or volume and tissue or organ damage. Recently, many authors have focused their attention on mesenchymal stem cells for their capacity to differentiate into many cell lineages. The most widely studied types are bone marrow mesenchymal stem cells and adipose-derived stem cells (ADSCs), which display similar results. Based on the literature, we believe that the ADSCs offer advantages because of lower morbidity during the harvesting procedure. Additionally, platelet-rich plasma can be used in this field for its ability to stimulate tissue regeneration. The aims of this article are to describe ADSC preparation and isolation procedures, preparation of platelet-rich plasma, and the application of ADSCs in regenerative plastic surgery. We also discuss the mechanisms and future role of ADSCs in cell-based therapy and tissue engineering.
authors.affiliation: Plastic and Reconstructive Surgery Department Tor Vergata University, Rome, Italy. pietrogentile2004@libero.it
authors.forename: Pietro
authors.initials: P
authors.lastname: Gentile
authors.forename: Augusto
authors.initials: A
authors.lastname: Orlandi
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Scioli
authors.forename: Camilla
authors.initials: C
authors.lastname: Di Pasquali
authors.forename: Ilaria
authors.initials: I
authors.lastname: Bocchini
authors.forename: Valerio
authors.initials: V
authors.lastname: Cervelli
mesh_terms: D000273:Adipose Tissue / Q000166:cytology* / Q000502:physiology; D002454:Cell Differentiation; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D053657:Platelet-Rich Plasma; D044968:Regenerative Medicine; D017154:Stromal Cells / Q000166:cytology* / Q000502:physiology; D013518:Surgery, Plastic; D023822:Tissue Engineering