title: [The mechanism of HBV disruption on RIG-I signaling pathway].
abstract: Hepatitis B virus (HBV) infection disrupt the innate immunity response, which may play an important role in the chronic mechanism, while retinoic acid-induced gene I (RIG-I) mediated signaling pathway is one of the most important channel in the innate immunity. HBx and HBV polymerase may disrupt RIG-I mediated signaling pathway. The recent advances about HBV and RIG-I are reviewed in this article.
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Libo
authors.initials: L
authors.lastname: Yan
authors.forename: Feijun
authors.initials: F
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Tang
mesh_terms: D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D015684:Gene Products, pol / Q000378:metabolism; D006509:Hepatitis B / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D011971:Receptors, Immunologic; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism; D054334:Viral Regulatory and Accessory Proteins
chemical_list: D015684:Gene Products, pol; C066027:P protein, Hepatitis B virus; D011971:Receptors, Immunologic; D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases