title: On programmed ribosomal frameshifting: the alternative proteomes.
abstract: FRAMESHIFTING RESULTS FROM TWO MAIN MECHANISMS: genomic insertions or deletions (indels) or programmed ribosomal frameshifting. Whereas indels can disrupt normal protein function, programmed ribosomal frameshifting can result in dual-coding genes, each of which can produce multiple functional products. Here, I summarize technical advances that have made it possible to identify programmed ribosomal frameshifting events in a systematic way. The results of these studies suggest that such frameshifting occurs in all genomes, and I will discuss methods that could help characterize the resulting alternative proteomes.
authors.affiliation: MRC Laboratory for Molecular Cell Biology, Translational Research Resource Centre, University College London London, UK.
authors.forename: Robin
authors.initials: R
authors.lastname: Ketteler