title: Orchestral actions of angiopoietin-1 in vascular regeneration.
abstract: Among many proangiogenic growth factors, angiopoietin-1 (Ang1, or ANGPT1) is unique because it can induce distinctive vascular remodeling through highly organized angiogenesis and tightening of endothelial cell (EC) junctions. These effects are mediated by synchronous activation of both vascular Tie2 and nonvascular integrin signaling, making Ang1 a viable candidate for therapeutic neovascularization and vascular protection. Ang1 helps delay diabetic complications by restoring microvascular function and can maintain the quiescence of some adult stem cells. Interestingly, Ang1 is dispensable for maintaining normal vasculature throughout adulthood, challenging the original concept of its functions in cell survival and stabilization in quiescent vasculature. This review summarizes recent advances in understanding the biomedical implications of Ang1 and discusses its multifaceted roles in vascular diseases, the mechanisms underlying its effects, and potential therapeutic applications.
authors.affiliation: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, South Korea. gykoh@kaist.ac.kr
authors.forename: Gou Young
authors.initials: GY
authors.lastname: Koh
mesh_terms: D053687:Adult Stem Cells / Q000187:drug effects / Q000378:metabolism; D042683:Angiopoietin-1 / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D048909:Diabetes Complications / Q000188:drug therapy; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000502:physiology*; D042787:Receptor, TIE-2 / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology
chemical_list: D042683:Angiopoietin-1; D016023:Integrins; D042461:Vascular Endothelial Growth Factor A; D042787:Receptor, TIE-2