title: The integration of signaling and the spatial organization of the T cell synapse.
abstract: Engagement of the T cell antigen receptor (TCR) triggers signaling pathways that lead to T cell selection, differentiation and clonal expansion. Superimposed onto the biochemical network is a spatial organization that describes individual receptor molecules, dimers, oligomers and higher order structures. Here we discuss recent findings and new concepts that may regulate TCR organization in naïve and memory T cells. A key question that has emerged is how antigen-TCR interactions encode spatial information to direct T cell activation and differentiation. Single molecule super-resolution microscopy may become an important tool in decoding receptor organization at the molecular level.
authors.affiliation: Centre for Vascular Research and Australian Centre for Nanomedicine, University of New South Wales Sydney, NSW, Australia.
authors.forename: Jérémie
authors.initials: J
authors.lastname: Rossy
authors.forename: David J
authors.initials: DJ
authors.lastname: Williamson
authors.forename: Carola
authors.initials: C
authors.lastname: Benzing
authors.forename: Katharina
authors.initials: K
authors.lastname: Gaus