title: Highly stable amorphous calcium phosphate porous nanospheres: microwave-assisted rapid synthesis using ATP as phosphorus source and stabilizer, and their application in anticancer drug delivery.
abstract: Highly stable amorphous calcium phosphate (ACP) porous nanospheres with a relatively uniform size and an average pore diameter of about 10 nm have been synthesized by using a microwave-assisted hydrothermal method with adenosine 5'-triphosphate disodium salt (ATP) as the phosphorus source and stabilizer. The as-prepared ACP porous nanospheres have a high stability in the phosphate buffer saline (PBS) solution for more than 150 h without phase transformation to hydroxyapatite, and the morphology and size were essentially not changed. The important role of ATP and effects of experimental conditions on the formation of ACP porous nanospheres were also investigated. The ACP porous nanospheres were characterized by X-ray powder diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). This method is facile, rapid, surfactant-free and environmentally friendly. The as-prepared ACP porous nanospheres are efficient for anticancer drug (docetaxel) loading and release. The ACP porous nanosphere drug-delivery system with docetaxel shows a high ability to damage tumor cells, thus, is promising for the application in anticancer treatment.
authors.affiliation: State Key Laboratory of High Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Qi
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Zhu
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Zhao
authors.forename: Bing-Qiang
authors.initials: BQ
authors.lastname: Lu
authors.forename: Qi-Li
authors.initials: QL
authors.lastname: Tang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D000077143:Docetaxel; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008872:Microwaves; D054118:Nanospheres; D016062:Porosity; D013329:Structure-Activity Relationship; D013499:Surface Properties; D043823:Taxoids / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D002130:Calcium Phosphates; D043823:Taxoids; D000077143:Docetaxel; D000255:Adenosine Triphosphate; C020243:calcium phosphate