title: Simvastatin-loaded β-TCP drug delivery system induces bone formation and prevents rhabdomyolysis in OVX mice.
abstract: Bone formation and regeneration is a prolonged process that requires a slow drug release system to assist in the long-term recovery. A drug-delivery system is developed that allows for the controlled release of simvastin, without exhibiting the side effects associated with high concentrations of simvastatin, and is still capable of inducing constant bone formation.
authors.affiliation: University of Technology Sydney, School of Medical and Molecular Sciences, Ultimo, Sydney, NSW, 2007, Australia. Joshua.chou@uts.edu.au
authors.forename: Joshua
authors.initials: J
authors.lastname: Chou
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ito
authors.forename: Makoto
authors.initials: M
authors.lastname: Otsuka
authors.forename: Besim
authors.initials: B
authors.lastname: Ben-Nissan
authors.forename: Bruce
authors.initials: B
authors.lastname: Milthorpe
mesh_terms: D000818:Animals; D002130:Calcium Phosphates / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000138:chemical synthesis*; D004058:Diffusion; D005260:Female; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage; D051379:Mice; D010012:Osteogenesis / Q000187:drug effects*; D010052:Ovariectomy; D012206:Rhabdomyolysis / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control*; D019821:Simvastatin / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C485817:beta-tricalcium phosphate; D019821:Simvastatin