title: Heat shock protein bystander antigens for peptide immunotherapy in autoimmune disease.
abstract: Mucosal administration of an antigen eliciting bystander suppression at the site of inflammation results in effective antigen-specific immunotherapy for autoimmune diseases. Heat shock proteins are bystander antigens that are effective in peptide-specific immunotherapy in both experimental and human autoimmune disease. The efficacy of preventive peptide immunotherapy is increased by enhancing peptide-specific immune responses with proinflammatory agents. Combining peptide-specific immunotherapy with general suppression of inflammation may improve its therapeutic effect.
authors.affiliation: Department of Pediatric Immunology, Centre for Cellular and Molecular Intervention, University Medical Centre Utrecht, Utrecht, the Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Zonneveld-Huijssoon
authors.forename: S
authors.initials: S
authors.lastname: Albani
authors.forename: B J
authors.initials: BJ
authors.lastname: Prakken
authors.forename: F
authors.initials: F
authors.lastname: van Wijk
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000941:Antigens / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D024201:Bystander Effect / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007113:Immunity, Innate; D007155:Immunologic Factors / Q000276:immunology / Q000627:therapeutic use; D007167:Immunotherapy; D051379:Mice; D010455:Peptides / Q000276:immunology / Q000627:therapeutic use*; D051381:Rats
chemical_list: D000941:Antigens; D006360:Heat-Shock Proteins; D007155:Immunologic Factors; D010455:Peptides