title: Autophagy protects proximal tubular cells from injury and apoptosis.
abstract: Autophagy is upregulated during ischemia-reperfusion (IR)-induced and cisplatin-induced acute kidney injury (AKI). Proximal tubule-specific Atg7 knockout mice exhibited increased renal injury compared with wild-type mice following cisplatin- and IR-induced AKI. Inhibition of autophagy by chloroquine aggravated AKI, whereas upregulation of autophagy by rapamycin recovered lost renal function and histology, further indicating a protective role of autophagy in AKI. These findings reported by Jiang et al. will provide stimulus to further examine the role and mechanism of the enhancement of autophagy in AKI.
authors.affiliation: Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA. kaushalgurp@uams.edu
authors.forename: Gur P
authors.initials: GP
authors.lastname: Kaushal
mesh_terms: D058186:Acute Kidney Injury / Q000517:prevention & control*; D000818:Animals; D001343:Autophagy; D007687:Kidney Tubules, Proximal / Q000473:pathology*; D015427:Reperfusion Injury / Q000517:prevention & control*