title: Disseminated Nocardiosis caused by Nocardia concava with acute respiratory failure and central nervous system involvement treated with linezolid.
abstract: Nocardia concava was identified as a new species in 2005; however, the clinical manifestations of Nocardia concava infection have yet to be clarified. We herein present the case of an immunosuppressed patient who developed disseminated nocardiosis caused by N. concava with multiple abscesses in the lungs, cutis, subcutaneous tissue, skeletal muscles and kidneys accompanied by central nervous system involvement, including meningitis and ventriculitis. The patient was cured with appropriate treatment including linezolid after testing for susceptibility. Linezolid should be considered as an alternative agent for treating disseminated nocardiosis because of its effective distribution to multiple sites.
authors.affiliation: Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Naoko
authors.initials: N
authors.lastname: Sueoka-Aragane
authors.forename: Natsuko
authors.initials: N
authors.lastname: Naganobu
authors.forename: Hitomi
authors.initials: H
authors.lastname: Umeguchi
authors.forename: Koji
authors.initials: K
authors.lastname: Kusaba
authors.forename: Zenzo
authors.initials: Z
authors.lastname: Nagasawa
authors.forename: Katsukiyo
authors.initials: K
authors.lastname: Yazawa
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.forename: Shinya
authors.initials: S
authors.lastname: Kimura
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Hayashi
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000208:Acute Disease; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D000069349:Linezolid; D008297:Male; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000627:therapeutic use; D009615:Nocardia / Q000145:classification / Q000187:drug effects / Q000235:genetics; D009617:Nocardia Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D023303:Oxazolidinones / Q000627:therapeutic use*; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000382:microbiology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D008911:Minocycline; D000069349:Linezolid