title: Measurement of inflammatory cytokines and thrombomodulin in chronic subdural hematoma.
abstract: Inflammation and the coagulation system may influence the genesis of chronic subdural hematoma (CSDH). The appearance of CSDH on computed tomography (CT) varies with the stage of the hematoma. This study investigated the pathogenesis and the recurrence of CSDH by comparing cytokine levels with the CT features of CSDH in 26 patients with 34 CSDHs who underwent single burr-hole surgery at our hospital between October 2004 and November 2006. The hematoma components removed during the procedure were examined, and the hematoma serum levels of cytokines measured such as thrombomodulin (TM), interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), and interleukin-10 (IL-10). Using CT, mixed density hematomas were distinguished from other homogeneous hematomas, and found that the TM level was significantly higher in mixed density hematomas than in homogeneous hematomas (p = 0.043). Mixed density hematomas were classified into three subtypes (laminar, separated, and trabecular hematomas). The TM level was significantly higher in laminar and separated hematomas than in other hematomas (p = 0.01). The levels of IL-6, TNFα, and IL-10 were extremely high, but showed no significant differences in relation to the CT features. Mixed density hematomas had high recurrence rate, as reported previously, and TM level was high in mixed density hematomas such as laminar and separated mixed density hematomas. The present findings suggest that the types of CSDH associated with high TM levels tend to have higher recurrence rate.
authors.affiliation: Department of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan. s9034@nms.ac.jp
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kitazono
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yokota
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Satoh
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Onda
authors.forename: Gaku
authors.initials: G
authors.lastname: Matsumoto
authors.forename: Akira
authors.initials: A
authors.lastname: Fuse
authors.forename: Akira
authors.initials: A
authors.lastname: Teramoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016207:Cytokines / Q000097:blood*; D005260:Female; D020200:Hematoma, Subdural, Chronic / Q000145:classification / Q000000981:diagnostic imaging / Q000276:immunology* / Q000601:surgery; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011379:Prognosis; D012008:Recurrence; D018180:Thrombomodulin / Q000097:blood*; D014057:Tomography, X-Ray Computed; D014207:Trephining; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D015850:Interleukin-6; D018180:Thrombomodulin; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10