title: [Transformation of myelodysplastic syndrome to acute lymphoblastic leukemia: 2 new cases].
abstract: Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cells, with a variable risk of transformation to acute myeloid leukemia. Progression into acute lymphoblastic leukemia (ALL) is an extremely rare event, with very few cases published in children. In this report, we describe two cases of myelodysplastic syndromes that progressed to ALL. Moreover, we review previously reported cases of MDS transformation to acute lymphoblastic leukemia in the pediatric population whose prognosis seems to be similar to that for adults.
authors.affiliation: Servicio de Hemato-Oncología Pediátrica, Hospital Infantil Universitario Niño Jesús, Madrid, España. maria.guillen@salud.madrid.org
authors.forename: M
authors.initials: M
authors.lastname: Guillén
authors.forename: L
authors.initials: L
authors.lastname: Madero
authors.forename: L
authors.initials: L
authors.lastname: Parra
authors.forename: C
authors.initials: C
authors.lastname: Hernández
authors.forename: B
authors.initials: B
authors.lastname: Herrero
authors.forename: F
authors.initials: F
authors.lastname: Carceller
authors.forename: A
authors.initials: A
authors.lastname: Lassaletta
authors.forename: J
authors.initials: J
authors.lastname: Sevilla
mesh_terms: D000208:Acute Disease; D002471:Cell Transformation, Neoplastic; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology*