title: Residue depletion of sulfachlorpyrazine in edible tissues of broiler chickens.
abstract: The residue depletion profile of sulfachlorpyrazine was studied in healthy broilers after oral administration of Sulfatyf®, given at a dose of 50 mg sulfachlorpyrazine (SCP) per kg body weight once daily for 3 consecutive days. Twenty-five medicated broilers were slaughtered on the 5th, 10th, 14th and 16th day of post-medication, and muscle, fat with skin, liver and kidney tissues were sampled and analysed using an high-performance liquid chromatography (HPLC) method with satisfactory recovery (74.5% ± 2.9%) and specificity. The estimated values of LOD and LOQ were 18.40 and 55.70 ng ml(-1), respectively. On the 5th and 10th day of post-medication, the concentrations of SCP residue in all samples examined were higher than the corresponding MRLs established by the European Union and the highest SCP concentrations were measured in muscle. A maximum withdrawal time of 14 days was calculated to ensure consumer safety.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland. beata-lebkowska@o2.pl
authors.forename: B
authors.initials: B
authors.lastname: Łebkowska-Wieruszewska
authors.forename: C J
authors.initials: CJ
authors.lastname: Kowalski
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002645:Chickens; D004350:Drug Residues / Q000032:analysis; D005506:Food Contamination / Q000032:analysis*; D008460:Meat / Q000032:analysis*; D013424:Sulfanilamides / Q000008:administration & dosage / Q000032:analysis*; D013997:Time Factors; D014018:Tissue Distribution; D000096926:Benzenesulfonamides
chemical_list: D013424:Sulfanilamides; C050643:sulfachlorpyrazine; D000096926:Benzenesulfonamides