title: Evaluation of the abdominal wall cicatrization of rabbits exposed to nicotine and undergone abdominoplasty using nylon thread or cyanoacrylate.
abstract: OBJECTIVE
  To compare the wound healing of the abdominal wall of rabbits exposed to nicotine and submitted to abdominoplasty using 2-octyl cyanoacrylate or nylon thread for the surgery suture.
  
  
  METHODS
  Thirty two rabbits were used. They were divided in subgroups: A1, A2, B1 e B2. Group A received saline 0.9%; group B received nicotine, both groups for 14 days before surgery. We performed an abdominoplasty with a nylon suture into the A1 and B1 subgroups; as for A2 and B2 groups the suture was performed with cyanoacrylate. The euthanasia happened in the 14th post-operative day. After, we evaluated: swollen process, fibroblast proliferation, collagen, neovascularization, and macroscope and microscope epithelization of the scars.
  
  
  RESULTS
  We observed the presence of eosinophils in all scars exposed to the cyanoacrylate, and a significant increase of neovascularization in the subgroup B2 comparing to the A2 one (p=0.037). The other variables haven't showed any statistical difference.
  
  
  CONCLUSIONS
  Nicotine hasn't influenced the swollen process, the fibroblast proliferation, the presence of collagen, neither the epithelialization. The neovascularization showed cicatricial immaturity when comparing group A2 to group B2. The eosinophils in the scars repaired with glue showed that the substance has acted as an allergen.
authors.affiliation: FCMMG, Minas Gerais, Brazil.
authors.forename: Luciano Assis
authors.initials: LA
authors.lastname: Costa
authors.forename: Paulo dos Reis
authors.initials: Pdos R
authors.lastname: Jardim
authors.forename: Pedro Henrique Alvares Paiva
authors.initials: PH
authors.lastname: Macedo
authors.forename: Vânia da Fonseca
authors.initials: Vda F
authors.lastname: Amaral
authors.forename: Alcino Lázaro da
authors.initials: AL
authors.lastname: Silva
authors.forename: Cirênio de Almeida
authors.initials: Cde A
authors.lastname: Barbosa
mesh_terms: D034861:Abdominal Wall / Q000473:pathology / Q000601:surgery*; D061645:Abdominoplasty; D000818:Animals; D002921:Cicatrix; D003487:Cyanoacrylates / Q000627:therapeutic use*; D009538:Nicotine / Q000494:pharmacology*; D009757:Nylons; D011817:Rabbits; D013537:Sutures; D013718:Tensile Strength / Q000187:drug effects; D013997:Time Factors; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D003487:Cyanoacrylates; D009757:Nylons; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate; D009538:Nicotine