title: Non-alcoholic steatohepatitis: the role of oxidized low-density lipoproteins.
abstract: Non-alcoholic steatohepatitis (NASH) is hallmarked by lipid accumulation in the liver (steatosis) along with inflammation (hepatitis). The transition from simple steatosis towards NASH represents a key step in pathogenesis, as it will set the stage for further severe liver damage. Yet, the pathogenesis behind hepatic inflammation is still poorly understood. It is of relevance to better understand the underlying mechanisms involved in NASH in order to apply new knowledge to potential novel therapeutic approaches. In the current review, we propose oxidized cholesterol as a novel risk factor for NASH. Here, we summarize mouse and human studies that provide possible mechanisms for the involvement of oxidized low-density lipoproteins in NASH and consequent potential novel diagnostic tools and treatment strategies for hepatic inflammation.
authors.affiliation: Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands.
authors.forename: Sofie M A
authors.initials: SM
authors.lastname: Walenbergh
authors.forename: Ger H
authors.initials: GH
authors.lastname: Koek
authors.forename: Veerle
authors.initials: V
authors.lastname: Bieghs
authors.forename: Ronit
authors.initials: R
authors.lastname: Shiri-Sverdlov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis; D005234:Fatty Liver / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007728:Kupffer Cells / Q000378:metabolism / Q000473:pathology; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D065626:Non-alcoholic Fatty Liver Disease; D012307:Risk Factors
chemical_list: D000975:Antioxidants; D018836:Inflammation Mediators; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein