title: Case report: Noonan-like multiple central giant cell granuloma syndrome.
abstract: The purpose of this report was to: summarize the care of a child between the ages of 12 to 16 years old born with Noonan-like central giant cell syndrome and unrelated common variable immune deficiency; provide information on the dental management of patients with Noonan's syndrome;  and present a brief discussion of the recent associated genetic findings. A review of the common features of Noonan syndrome and Noonan-like central giant cell syndrome is also provided.
authors.affiliation: Department of Pediatric Dentistry, Tufts University School of Dental Medicine, Boston, MA, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Bitton
authors.forename: Stanley
authors.initials: S
authors.lastname: Alexander
authors.forename: Salvatore
authors.initials: S
authors.lastname: Ruggiero
authors.forename: Ashish
authors.initials: A
authors.lastname: Parameswaran
authors.forename: Antonino
authors.initials: A
authors.lastname: Russo
authors.forename: Fred
authors.initials: F
authors.lastname: Ferguson
mesh_terms: D002648:Child; D017074:Common Variable Immunodeficiency / Q000150:complications*; D017742:Dental Care for Chronically Ill; D005260:Female; D006101:Granuloma, Giant Cell / Q000150:complications / Q000000981:diagnostic imaging / Q000209:etiology* / Q000235:genetics / Q000601:surgery; D006801:Humans; D008310:Malocclusion / Q000209:etiology; D008336:Mandibular Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D009634:Noonan Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics / Q000601:surgery; D009971:Orthodontics, Corrective; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000235:genetics; D011859:Radiography; D014071:Tooth Abnormalities / Q000209:etiology
chemical_list: C516724:PTPN11 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11