title: Diagnosis of lung cancer: a bronchoscopist's perspective.
abstract: BACKGROUND
  Guidelines recommend multiple types of cytologic and tissue samplings in the diagnosis of lung cancer by bronchoscopy, but differences of opinion exist as to the relative value of bronchial brushings and endobronchial or transbronchial biopsies. Our objective was to determine concordance of these procedures by a test of symmetry in a historical cohort referred to the pulmonary diagnostic laboratory.
  
  
  METHODS
  From 1988 to 2001, patients with pathologic confirmation of primary lung cancer were examined by standard bronchoscopic techniques of that period. An electronic medical record system was used, with statistical analysis of symmetry between brushings and biopsies establishing the diagnosis.
  
  
  RESULTS
  Of 968 patients, 98% had bronchoscopy for 624 central and 322 peripheral suspect lesions. Bronchial brushings from 915 patients confirmed pulmonary malignancy in 811 (89%) patients. Endobronchial or transbronchial biopsies from 739 patients showed lung cancer in 603 (82%) cases. Bronchial washings in 16 patients and transthoracic needle biopsies in 30 patients established diagnosis. Transbronchial needle aspiration of mediastinal nodes identified metastases in 94 patients. Only 14 patients required a surgical procedure for diagnosis, but 188 received surgical excision as primary treatment. Statistical evaluation used only patients with both bronchial brushings and endobronchial or transbronchial biopsies. Analysis by a test of symmetry showed a significant difference (P<0.0001).
  
  
  CONCLUSIONS
  Positive, suspicious, and negative specimens were consistent, with bronchial brushings being more sensitive with a lower false-negative rate than endobronchial or transbronchial biopsies. Multiple techniques are recommended for bronchoscopic confirmation of lung cancer, but bronchial brushings should be collected initially, as technical or patient limitations might preclude diagnostic tissue biopsies.
authors.affiliation: Pulmonary/Critical Care Section, Memphis Veterans Affairs Medical Center, Memphis, TN 38163, USA. jpgriffin@uthsc.edu
authors.forename: John P
authors.initials: JP
authors.lastname: Griffin
authors.forename: Muhammad K
authors.initials: MK
authors.lastname: Zaman
authors.forename: Harvey B
authors.initials: HB
authors.lastname: Niell
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Tolley
authors.forename: F Hammond
authors.initials: FH
authors.lastname: Cole
authors.forename: Darryl S
authors.initials: DS
authors.lastname: Weiman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D056808:Biostatistics / Q000379:methods*; D001980:Bronchi / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid; D001999:Bronchoscopy / Q000379:methods*; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D005260:Female; D005336:Fiber Optic Technology; D005471:Fluoroscopy; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods*