title: Automated three-component synthesis of a library of γ-lactams.
abstract: A three-component method for the synthesis of γ-lactams from commercially available maleimides, aldehydes, and amines was adapted to parallel library synthesis. Improvements to the chemistry over previous efforts include the optimization of the method to a one-pot process, the management of by-products and excess reagents, the development of an automated parallel sequence, and the adaption of the method to permit the preparation of enantiomerically enriched products. These efforts culminated in the preparation of a library of 169 γ-lactams.
authors.affiliation: Center of Excellence in Chemical Methodologies and Library Development, the University of Kansas, 2034 Becker Drive, Lawrence Kansas, 66047, USA.
authors.forename: Erik
authors.initials: E
authors.lastname: Fenster
authors.forename: David
authors.initials: D
authors.lastname: Hill
authors.forename: Oliver
authors.initials: O
authors.lastname: Reiser
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Aubé