title: Acute necrotizing pancreatitis in the setting of CMV viremia and AIDS: a case report and review of literature from 1980 to 2012.
abstract: BACKGROUND
  Cytomegalovirus (CMV)-induced pancreatitis in patients with AIDS is a known entity with poor prognosis.
  
  
  METHODS
  We report a case of a 43-year-old woman with AIDS and CMV viremia who was evaluated for hypotension and found to have severe necrotizing pancreatitis. The authors have also conducted a MEDLINE search for CMV-induced pancreatitis from 1980 to 2012 and reviewed the pertinent results.
  
  
  CONCLUSIONS
  Until mid-1990s in the United States, pancreatitis due to CMV was mainly diagnosed at autopsy in AIDS patients. However, presumably due to the advent of antiretroviral therapy, there has since been a significant decline in the number of reported cases among these individuals. Rather, our review revealed that the occurrence of CMV-induced pancreatitis has since been described in a variety of clinical settings, ranging from patients on corticosteroid therapy to immunocompetent persons.
  
  
  CONCLUSIONS
  Clinicians need a high index of suspicion to timely diagnose CMV-induced pancreatitis as patients often present with non-specific signs and symptoms. As it occurred in our case, early intervention is crucial and may alter the outcome in such patients.
authors.affiliation: Department of Medicine, Woodhull Medical Center. Brooklyn, NY, USA. berilonson@gmail.com
authors.forename: Stephen
authors.initials: S
authors.lastname: Osiro
authors.forename: Raza
authors.initials: R
authors.lastname: Muhammad
authors.forename: Jose
authors.initials: J
authors.lastname: Ruiz
authors.forename: Anatole
authors.initials: A
authors.lastname: Sladen
authors.forename: Njambi
authors.initials: N
authors.lastname: Mathenge
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Tiwari
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D015415:Biomarkers; D003586:Cytomegalovirus Infections / Q000150:complications*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014766:Viremia / Q000150:complications*
chemical_list: D015415:Biomarkers