title: Antineutrophil cytoplasmic autoantibody-associated vasculitis in Chinese patients.
abstract: Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a common autoimmune disease in China. AAVs in the majority of Chinese patients are microscopic polyangiitis with antigenicity to myeloperoxidase. Propylthiouracil is the leading cause of drug-induced AAV. The genetic background and immunological characteristics of ANCA, such as the epitope, IgG subclass and avidity, might contribute to various clinical phenotypes of AAV.
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.|Institute of Nephrology, Peking University, Beijing, China.|Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, China.|Department of Nephrology, General Hospital of Tianjin Medical University, Tianjin, 300052, China.
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Xu
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.|Institute of Nephrology, Peking University, Beijing, China.|Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China. mhzhao@bjmu.edu.cn.|Institute of Nephrology, Peking University, Beijing, China. mhzhao@bjmu.edu.cn.|Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China. mhzhao@bjmu.edu.cn.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, China. mhzhao@bjmu.edu.cn.|Peking-Tsinghua Center for Life Sciences, Beijing, 100871, China. mhzhao@bjmu.edu.cn.
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Zhao
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics / Q000276:immunology; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D013956:Antithyroid Agents / Q000009:adverse effects; D044466:Asian People / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D053146:Myeloblastin / Q000276:immunology; D009195:Peroxidase / Q000276:immunology; D010641:Phenotype; D011379:Prognosis; D011441:Propylthiouracil / Q000009:adverse effects; D012307:Risk Factors
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D015415:Biomarkers; D011441:Propylthiouracil; D009195:Peroxidase; D053146:Myeloblastin