title: A multicenter study on the prevalence of eosinophilic esophagitis and PPI-responsive esophageal eosinophilic infiltration.
abstract: OBJECTIVE
  Eosinophilic esophagitis (EoE) is diagnosed by the presence of dysphagia and intraepithelial eosinophilic infiltration of ≥15 per high-power field (HPF). EoE should be distinguished from proton pump inhibitor-responsive esophageal eosinophilic infiltration (PPI-R EEI) in patients that are responsive to PPI treatment. The aim of this study was to determine the prevalence of EoE and PPI-R EEI in Japanese patients in a multicenter study.
  
  
  METHODS
  Ten hospitals participated in this study. Esophageal biopsy was performed when the patients had typical EoE symptoms or when endoscopic findings revealed a typical EoE appearance. EEI was defined as the intraepithelial eosinophilic infiltration of ≥15 per HPF. Patients with EEI received rabeprazole for 8 weeks to distinguish EoE from PPI-R EEI.
  
  
  RESULTS
  A total of 13,634 subjects that underwent upper gastrointestinal endoscopy because of further examination or as a routine checkup were enrolled. Seventy-one (0.5%) patients suspected with EoE were examined by biopsy. A histological examination of 7 (9.9%) cases revealed EEI. Two of these 7 patients showed no symptoms and the other 5 were treated with PPI. Two (0.01%) patients were diagnosed with EoE and 3 (0.02%) with PPI-R EEI.
  
  
  CONCLUSIONS
  EoE and PPI-R EEI were rare in Japanese patients that underwent upper gastrointestinal endoscopy.
authors.affiliation: Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan. yasu@med.osaka-cu.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugawa
authors.forename: Fumio
authors.initials: F
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tatsuwaki
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Okuyama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yamamori
authors.forename: Rikimon
authors.initials: R
authors.lastname: Wada
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Ohtani
authors.forename: Hironori
authors.initials: H
authors.lastname: Uno
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Kazunari
authors.initials: K
authors.lastname: Tominaga
authors.forename: Toshio
authors.initials: T
authors.lastname: Watanabe
authors.forename: Osamu
authors.initials: O
authors.lastname: Takaishi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Saeki
authors.forename: Hiroko
authors.initials: H
authors.lastname: Nebiki
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Oshitani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Arakawa
mesh_terms: D000328:Adult; D000368:Aged; D004802:Eosinophilia / Q000473:pathology; D057765:Eosinophilic Esophagitis / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D004947:Esophagus / Q000473:pathology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors