title: LncRNAs have a say in protein translation.
abstract: In a recent paper published in Nature, Carrieri et al. have identified in mouse a neuron-specific antisense lncRNA transcribed in the opposite strand of Uchl1 mRNA. Antisense Uchl1 specifically promotes the translation of UCHL1 under rapamycin treatment. To do so, the lncRNA only requires a SINEB2 repeat and a small region with sequence complementarity to the regulated mRNA.
authors.affiliation: Regulation of Gene Expression Laboratory, Division of Oncology, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. maitehuarte@unav.es
authors.forename: Maite
authors.initials: M
authors.lastname: Huarte
mesh_terms: D000818:Animals; D006801:Humans; D008297:Male; D014176:Protein Biosynthesis / Q000235:genetics*; D016372:RNA, Antisense / Q000378:metabolism*; D020086:Short Interspersed Nucleotide Elements / Q000235:genetics*; D043222:Ubiquitin Thiolesterase / Q000235:genetics* / Q000378:metabolism*
chemical_list: D016372:RNA, Antisense; D043222:Ubiquitin Thiolesterase