title: Aspirin-intolerant asthma in the Korean population: prevalence and characteristics based on a questionnaire survey.
abstract: BACKGROUND
  Aspirin-intolerant asthma is a unique clinical syndrome characterized by acute bronchoconstriction following the administration of aspirin and/or non-steroidal anti-inflammatory drugs.
  
  
  OBJECTIVE
  We assessed the prevalence and investigated the demographic and clinical characteristics of adult patients with aspirin-intolerant asthma in Korea.
  
  
  METHODS
  Using an adult asthma cohort (COREA) from 11 university hospitals in Korea, we analyzed the prevalence of aspirin-intolerant asthma, defined as a positive response to the question: "Have you ever experienced dyspnea and cough after taking an aspirin or any NSAID (cold medicine)?" Demographic and clinical characteristics were compared between patients with aspirin-intolerant asthma and aspirin-tolerant asthma.
  
  
  RESULTS
  Aspirin-intolerant asthma was reported in 68 (5.8%) of 1173 adult asthmatics (age 15-84). Patients with aspirin-intolerant asthma had a lower mean age (43.9 ± 13.4 vs. 49.0 ± 15.6, P = 0.003) and a higher prevalence of rhinosinusitis (77.9% vs. 61.7%, P = 0.012) and atopic dermatitis (16.2% vs. 5.7%, P = 0.001) than aspirin-tolerant asthma patients. There were no significant differences in lung function, asthma severity or the use of asthma controllers. However, aspirin-intolerant asthma was associated with greater use of healthcare services over a lifetime and over the past 12 months. Aspirin-intolerant asthma was significantly associated with emergency room visits over the past 12 months (P = 0.029, OR 2.19, 95% CI 1.08-4.42).
  
  
  CONCLUSIONS
  Based on histories, the prevalence of aspirin-intolerant asthma is 5.8% among adult asthma patients in Korea. Aspirin-intolerant asthma is associated with lower age, higher prevalence of rhinosinusitis and atopic dermatitis, and more frequent exacerbations.
authors.affiliation: Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
authors.forename: Ji-Yong
authors.initials: JY
authors.lastname: Moon
authors.forename: Sang-Heon
authors.initials: SH
authors.lastname: Kim
authors.forename: Tae-Bum
authors.initials: TB
authors.lastname: Kim
authors.forename: Sae-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Yoon-Seok
authors.initials: YS
authors.lastname: Chang
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: You Sook
authors.initials: YS
authors.lastname: Cho
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Park
authors.forename: An-Soo
authors.initials: AS
authors.lastname: Jang
authors.forename: Choon-Sik
authors.initials: CS
authors.lastname: Park
authors.forename: Dong-Ho
authors.initials: DH
authors.lastname: Nahm
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Cho
authors.forename: Sang-Heon
authors.initials: SH
authors.lastname: Cho
authors.forename: Byoung-Whui
authors.initials: BW
authors.lastname: Choi
authors.forename: Hee-Bom
authors.initials: HB
authors.lastname: Moon
authors.forename: Ho Joo
authors.initials: HJ
authors.lastname: Yoon
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000627:therapeutic use; D003695:Delivery of Health Care / Q000706:statistics & numerical data; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014797:Vital Capacity / Q000187:drug effects; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001993:Bronchodilator Agents; D001241:Aspirin