title: Lack of p53 affects the expression of several brain mitochondrial proteins: insights from proteomics into important pathways regulated by p53.
abstract: The tumor suppressor protein p53 has been described "as the guardian of the genome" for its crucial role in regulating the transcription of numerous genes responsible for cells cycle arrest, senescence, or apoptosis in response to various stress signals. Although p53 promotes longevity by decreasing the risk of cancer through activation of apoptosis or cellular senescence, several findings suggest that an increase of its activity may have deleterious effects leading to selected aspects of the aging phenotype and neurodegenerative diseases. There is the link between p53 and oxidative stress, the latter a crucial factor that contributes to neurodegenerative processes like Alzheimer disease (AD). In the present study, using a proteomics approach, we analyzed the impact of lack of p53 on the expression of several brain mitochondrial proteins involved in different pathways, and how lack of p53 may present a target to restore neuronal impairments. Our investigation on isolated brain mitochondria from p53((-/-)) mice also provides a better understanding of the p53-mitochondria relationship and its involvement in the development of many diseases.
authors.affiliation: Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
authors.forename: Ada
authors.initials: A
authors.lastname: Fiorini
authors.forename: Rukhsana
authors.initials: R
authors.lastname: Sultana
authors.forename: Eugenio
authors.initials: E
authors.lastname: Barone
authors.forename: Giovanna
authors.initials: G
authors.lastname: Cenini
authors.forename: Marzia
authors.initials: M
authors.lastname: Perluigi
authors.forename: Cesare
authors.initials: C
authors.lastname: Mancuso
authors.forename: Jian
authors.initials: J
authors.lastname: Cai
authors.forename: Jon B
authors.initials: JB
authors.lastname: Klein
authors.forename: Daret
authors.initials: D
authors.lastname: St Clair
authors.forename: D Allan
authors.initials: DA
authors.lastname: Butterfield
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000235:genetics* / Q000378:metabolism*; D008954:Models, Biological; D040901:Proteomics; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*
chemical_list: D024101:Mitochondrial Proteins; D016159:Tumor Suppressor Protein p53