title: In situ and intraductal epithelial proliferations of prostate: definitions and treatment implications. Part 2: intraductal carcinoma and ductal adenocarcinoma of prostate.
abstract: • High-grade prostatic intraepithelial neoplasia (HGPIN) is an intracellular proliferation of ductal epithelial cells. On its own, the presence of HGPIN does not warrant active intervention. • In contrast, intraductal carcinoma of prostate and prostatic ductal adenocarcinoma of prostate are markers of aggressive prostatic adenocarcinoma. • The presence of even small foci of these tumours on biopsy warrants immediate intervention, even in the absence of demonstrable invasive disease. • This second part of the review of in situ epithelial proliferations of the prostate looks at these conditions in more detail.
authors.affiliation: Focus Pathology, South Yarra, Victoria, Australia. David.Clouston@focuspathology.com.au
authors.forename: David
authors.initials: D
authors.lastname: Clouston
authors.forename: Damien
authors.initials: D
authors.lastname: Bolton
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D044963:Biopsy, Fine-Needle; D001707:Biopsy, Needle; D044584:Carcinoma, Ductal / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D049109:Cell Proliferation; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D019160:Endosonography; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D019048:Prostatic Intraepithelial Neoplasia / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D014521:Urethra