title: Junín virus pathogenesis and virus replication.
abstract: Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina. Recently, significant progress has been achieved with the development of new technologies (e.g. reverse genetics) that have expanded knowledge about the pathogenesis and viral replication of Junín virus. We will review the pathogenesis of Junín virus in various animal models and the role of innate and adaptive immunity during infection. We will highlight current research regarding the role of molecular biology of Junín virus in elucidating virus attenuation. We will also summarize current knowledge on Junín virus pathogenesis focusing on the recent development of vaccines and potential therapeutics.
authors.affiliation: Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA. amgrant@utmb.edu
authors.forename: Ashley
authors.initials: A
authors.lastname: Grant
authors.forename: Alexey
authors.initials: A
authors.lastname: Seregin
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Olga
authors.initials: O
authors.lastname: Kolokoltsova
authors.forename: Allan
authors.initials: A
authors.lastname: Brasier
authors.forename: Clarence
authors.initials: C
authors.lastname: Peters
authors.forename: Slobodan
authors.initials: S
authors.lastname: Paessler
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000914:Antibodies, Viral; D001117:Arenaviridae Infections / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control / Q000821:virology; D004195:Disease Models, Animal; D018562:Disease Transmission, Infectious / Q000517:prevention & control; D006801:Humans; D007113:Immunity, Innate; D018051:Junin virus / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D008562:Membrane Glycoproteins / Q000276:immunology; D012377:Rodentia / Q000821:virology; D014613:Vaccines, Attenuated / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology; D053586:Virus Internalization; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral; C555941:GPC protein, junin virus; D008562:Membrane Glycoproteins; D014613:Vaccines, Attenuated; D014759:Viral Envelope Proteins; D014765:Viral Vaccines