title: Diffuse large B-cell lymphoma in human T-lymphotropic virus type 1 carriers.
abstract: We describe the clinical and pathological characteristics of seven patients who were human T-lymphotropic virus type 1 (HTLV-1) carriers and had a pathological diagnosis of de novo diffuse large B-cell lymphoma. Interestingly, three of our cases showed positive expression of Epstein-Barr-virus, (EBV-) encoded RNA within the tumor cells indicating a possible interaction between these two viruses. Furthermore, our three EBV-positive cases presented with similar clinical characteristics such as early clinical stage and low-risk indices. To the best of our knowledge, this is the first case series describing the characteristics of HTLV-1-positive DLBCL patients. The potential relationship between HTLV-1 and EBV should be further explored.
authors.affiliation: Department of Oncology and Radiotherapy, Edgardo Rebagliati Martins Hospital, Lima, Peru.
authors.forename: Brady E
authors.initials: BE
authors.lastname: Beltran
authors.forename: Pilar
authors.initials: P
authors.lastname: Quiñones
authors.forename: Domingo
authors.initials: D
authors.lastname: Morales
authors.forename: Jose C
authors.initials: JC
authors.lastname: Revilla
authors.forename: Jose C
authors.initials: JC
authors.lastname: Alva
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Castillo