title: Grafting of carboxybetaine brush onto cellulose membranes via surface-initiated ARGET-ATRP for improving blood compatibility.
abstract: Grafting-from has proven to be a very effective way to create high grafting densities and well-controlled polymer chains on different kinds of surfaces. In this work, we aim to graft zwitterionic brush from cellulose membrane (CM) via ARGET-ATRP (Activator Regenerated by Electron Transfer ATRP) method indirectly for blood compatibility improvement. Characterization of the CM substrates before and after modification was carried out by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), water contact angle measurements, X-ray photoelectron spectroscopy analysis, and atomic force microscopy, respectively. The results demonstrated zwitterionic brushes were successfully grafted on the CM surfaces, and the content of the grafted layer increased gradually with the polymerization time. The platelet adhesion, hemolytic test and plasma protein adsorption results indicated the cellulose membrane had significantly excellent blood compatibility featured on lower platelet adhesion and protein adsorption without causing hemolysis. The functionalized cellulose substrate could have a great potential usage for biomedical applications.
authors.affiliation: Jiangsu Key laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Miao
authors.initials: M
authors.lastname: Wang
authors.forename: Jiang
authors.initials: J
authors.lastname: Yuan
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Huang
authors.forename: Xianmei
authors.initials: X
authors.lastname: Cai
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000327:Adsorption; D001622:Betaine / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D004583:Electrons; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D008567:Membranes, Artificial; D008689:Methacrylates / Q000737:chemistry; D018625:Microscopy, Atomic Force; D056951:Photoelectron Spectroscopy; D010973:Platelet Adhesiveness; D058105:Polymerization; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D008689:Methacrylates; D014867:Water; D001622:Betaine; D002482:Cellulose; C049840:2-(dimethylamino)ethyl methacrylate