title: [Advances of utilizing microRNAs as biomarkers].
abstract: MicroRNAs (miRNAs) are a new class of endogenous, single-strand, noncoding small RNAs. MiRNAs play an important regulatory role in a variety of pathological and physiological process, such as cell proliferation and apoptosis, organ development and differentiation and tumorigenesis and so on. It has been found that circulating miRNAs are also stably and specially expressed in serum or plasma and other body fluids. Circulating miRNAs could be taken as noninvasive and new biomarkers for evaluating the drug-induced target organ injury, which may play a vital role in monitoring the drug toxicity at the early stage.
authors.affiliation: Research Center for drug Safety Evaluation, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. qiaojingyi618@yahoo.cn
authors.forename: Jingyi
authors.initials: J
authors.lastname: Qiao
authors.forename: Ruomin
authors.initials: R
authors.lastname: Jin
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D003933:Diagnosis; D004194:Disease / Q000235:genetics; D016903:Drug Monitoring / Q000295:instrumentation / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs