title: [The proapoptotic p53 (C72G) and p21 (C31A) polymorphisms as the risk factors for the development of primary open-angle glaucoma in Transbaikalian region].
abstract: The incidence of p53 (C72G) and p21 (C31A) proapoptotic polymorphisms is studied in Russian and Buryat population of Transbaicalian region and prognostic value of these polymorphisms in development of primary open-angle glaucoma (POAG) is assessed. Significant difference in incidence of p53 and p21 was found between healthy subjects and glaucoma patients in both ethnic groups. The incidence of C and G variants of p53-gene and C and A variants of p21-gene differ in glaucoma patients and healthy subjects. The study lets us propose that p53 (C72G) and p27 (C31A) polymorphisms contribute to the risk of POAG onset in Russian and Buryat population as well.
authors.forename: N A
authors.initials: NA
authors.lastname: Logunov
authors.forename: A I
authors.initials: AI
authors.lastname: Belousova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Vitkovskiĭ
mesh_terms: D044466:Asian People / Q000235:genetics; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D005902:Glaucoma, Open-Angle / Q000208:ethnology / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D012800:Siberia / Q000453:epidemiology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D050759:Cyclin-Dependent Kinase Inhibitor p21; D016159:Tumor Suppressor Protein p53