title: pH-responsive composite microspheres based on magnetic mesoporous silica nanoparticle for drug delivery.
abstract: pH-responsive composite microspheres, consisting of a core of Fe₃O₄ nanoparticle, a sandwiched layer of mesoporous silica and a shell of crosslinked poly (methacrylic acid) (PMAA), were successfully synthesized via distillation precipitation polymerization. The pKa of the composite microsphere increased with the increase in the crosslinking density. Doxorubicin hydrochloride (DOX) was applied as a model drug, and the behavior of drug storage/release was investigated. The cumulative release of DOX-loaded composite microsphere in vitro showed that the drug release rate was much faster below its pKa than that of above its pKa. Because pH of most tumor tissues was lower than that of normal tissues, the pH-responsive composite microspheres are promising drug delivery system especially for cancer therapy.
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wen
authors.forename: Jia
authors.initials: J
authors.lastname: Guo
authors.forename: Baisong
authors.initials: B
authors.lastname: Chang
authors.forename: Wuli
authors.initials: W
authors.lastname: Yang
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008280:Magnetics / Q000379:methods*; D008863:Microspheres; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D012822:Silicon Dioxide / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D012822:Silicon Dioxide