title: Comparison of efficacy of three commercially available dentifrices [corrected] on dentinal hypersensitivity: a randomized clinical trial.
abstract: BACKGROUND
  Dentinal hypersensitivity has been defined as a short, sharp pain arising from exposed dentine as a result of various stimuli such as heat, cold, chemical, or osmotic, that cannot be ascribed to any other pathology. This study was conducted to assess the efficacy of three commercially available toothpastes in the reduction of dentinal hypersensitivity.
  
  
  METHODS
  A total of 149 subjects (72 males and 77 females; aged 20 to 60 years) were entered into the study and randomly divided into four groups: Group 1 - toothpaste containing 5% potassium nitrate; Group 2 - toothpaste containing 5% calcium sodium phosphosilicate with fused silica; Group 3 - toothpaste containing 3.85% amine fluoride; and Group 4 - a placebo toothpaste. After sensitivity scores for controlled air stimulus and cold water at baseline were recorded, subjects were given toothpastes and sensitivity scores were measured again at 2 weeks and 6 weeks.
  
  
  RESULTS
  All groups showed a reduction in sensitivity scores at 2 weeks and 6 weeks. The calcium sodium phosphosilicate group was found to be significantly better compared to the other groups at the end of 6 weeks.
  
  
  CONCLUSIONS
  The calcium sodium phosphosilicate group showed a better reduction in the symptoms of dentinal hypersensitivity.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, India. periodonticsgdcri@gmail.com
authors.forename: A R
authors.initials: AR
authors.lastname: Pradeep
authors.forename: E
authors.initials: E
authors.lastname: Agarwal
authors.forename: S B
authors.initials: SB
authors.lastname: Naik
authors.forename: P
authors.initials: P
authors.lastname: Bajaj
authors.forename: N
authors.initials: N
authors.lastname: Kalra
mesh_terms: D000328:Adult; D000588:Amines / Q000627:therapeutic use; D000704:Analysis of Variance; D003807:Dentin Sensitivity / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000627:therapeutic use; D017680:Potassium Compounds / Q000627:therapeutic use; D017640:Silicates / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D014002:Tin Fluorides / Q000627:therapeutic use; D014100:Toothpastes / Q000737:chemistry / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000588:Amines; D009566:Nitrates; D017680:Potassium Compounds; D017640:Silicates; D014002:Tin Fluorides; D014100:Toothpastes; C075174:amine fluoride gel; D012969:Sodium Fluoride; C023844:potassium nitrate