title: Increased arterial stiffness in subjects with impaired fasting glucose.
abstract: OBJECTIVE
  The present study investigated the association between fasting glucose and arterial stiffness in subjects with normal fasting glucose (NFG) and impaired fasting glucose (IFG).
  
  
  METHODS
  The study group consisted of 1043 subjects, including 683 subjects with NFG and 360 subjects with IFG (100≤fasting glucose <126 mg/dL). All subjects were evaluated for glucose, insulin, lipid profiles, high sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), 8-epi-prostaglandin F2α (8-epi-PGF2α) and brachial-ankle pulse wave velocity (ba-PWV).
  
  
  RESULTS
  MDA (P<0.001) and ba-PWV (P<0.001) in the IFG group were higher than those in the NFG group after adjustment for sex, age, BMI, smoking and drinking, waist, blood pressure, serum lipid profiles. Ba-PWV in the IFG group was still higher than that in the NFG group after further adjustment for hs-CRP, MDA, 8-epi-PGF2α (P=0.031). Through multiple linear regression analysis, ba-PWV was found to be independently and positively associated with fasting glucose, age, systolic blood pressure, triglyceride, hs-CRP and insulin and negatively associated with male:female ratio, BMI.
  
  
  CONCLUSIONS
  Arterial stiffness was higher in the IFG group than in subjects with NFG even after adjustment for all confounding variables including hs-CRP and oxidative stress markers. In addition, fasting glucose and insulin were positively and independently associated with the ba-PWV in non-diabetic healthy adults.
authors.affiliation: Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea.
authors.forename: Jean Kyung
authors.initials: JK
authors.lastname: Paik
authors.forename: Minjoo
authors.initials: M
authors.lastname: Kim
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Kwak
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Lee
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Lee
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000328:Adult; D055109:Ankle Brachial Index; D001158:Arteries / Q000276:immunology / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000276:immunology / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D008315:Malondialdehyde; D002097:C-Reactive Protein