title: Assessing clinical and functional outcomes in a gene-environment interaction study in first episode of psychosis (PEPs).
abstract: The PEPs study is a multicenter, naturalistic, prospective, longitudinal study designed to evaluate clinical, neuropsychological, neuroimaging, biochemical, environmental and pharmacogenetic variables in a sample of nearly 350 first episode of psychosis patients and 250 healthy controls. The PEPs project was conducted in Spain from January 2009 to December 2011. This article describes the rationale for the measurement approach adopted, providing an overview of the selected clinical and functional measures. The main objectives are: a) the thorough clinical and neurocognitive characterization of a sample of first episodes of psychosis, and b) the study of the interactions between the genetic and environmental variables selected to predict clinical and brain structural outcomes, and to determine the relationship of genetic polymorphisms involved in the pharmacokinetics and pharmacodynamics, and the responses and adverse effects of treatment.
authors.affiliation: Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Spain. bernardo@clinic.ub.es
authors.forename: Miquel
authors.initials: M
authors.lastname: Bernardo
authors.forename: Miquel
authors.initials: M
authors.lastname: Bioque
authors.forename: Mara
authors.initials: M
authors.lastname: Parellada
authors.forename: Jerónimo
authors.initials: J
authors.lastname: Saiz Ruiz
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Cuesta
authors.forename: Adrián
authors.initials: A
authors.lastname: Llerena
authors.forename: Julio
authors.initials: J
authors.lastname: Sanjuán
authors.forename: Josefina
authors.initials: J
authors.lastname: Castro-Fornieles
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
authors.forename: Bibiana
authors.initials: B
authors.lastname: Cabrera
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D002648:Child; D002985:Clinical Protocols; D018450:Disease Progression; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies; D011581:Psychological Tests; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D013030:Spain; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents