title: Soluble receptor for advanced glycation end products and liver stiffness in postoperative biliary atresia.
abstract: OBJECTIVE
  Soluble receptor for advanced glycation end products (sRAGE) has emerged as a possible biomarker of several disease conditions, including liver injury. This study was aimed to assess serum sRAGE and liver stiffness in biliary atresia (BA).
  
  
  METHODS
  Forty postoperative BA patients and 20 controls were enrolled. Serum sRAGE levels were analyzed by enzyme-linked immunosorbent assay. Liver stiffness scores were measured by transient elastography.
  
  
  RESULTS
  BA patients had higher serum sRAGE and liver stiffness values than controls (P<0.001). Serum sRAGE and liver stiffness values were significantly elevated in BA patients with jaundice compared to those without jaundice (P<0.001). Additionally, serum sRAGE was correlated with liver stiffness and serum total bilirubin (r=0.65, P<0.001 and r=0.71, P<0.001, respectively).
  
  
  CONCLUSIONS
  Serum sRAGE was associated with the severity of BA. Accordingly, serum sRAGE and liver stiffness may serve as indicators reflecting the severity and the development of hepatic fibrosis in postoperative BA.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand. Sittisak.H@chula.ac.th
authors.forename: Sittisak
authors.initials: S
authors.lastname: Honsawek
authors.forename: Paisarn
authors.initials: P
authors.lastname: Vejchapipat
authors.forename: Sunchai
authors.initials: S
authors.lastname: Payungporn
authors.forename: Apiradee
authors.initials: A
authors.lastname: Theamboonlers
authors.forename: Voranush
authors.initials: V
authors.lastname: Chongsrisawat
authors.forename: Yong
authors.initials: Y
authors.lastname: Poovorawan
mesh_terms: D001656:Biliary Atresia / Q000150:complications*; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers; D016022:Case-Control Studies; D002648:Child; D054459:Elasticity Imaging Techniques; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D041781:Jaundice, Obstructive / Q000150:complications; D008099:Liver / Q000473:pathology* / Q000601:surgery; D008111:Liver Function Tests; D008297:Male; D011183:Postoperative Complications; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D012720:Severity of Illness Index; D012995:Solubility
chemical_list: D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D001663:Bilirubin