title: Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology.
abstract: Receptor tyrosine kinases are high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. They straddle the cell wall and play an important role in cross-membrane signalling. We present a two-component systems pharmacology model based on the local physiology and identify characteristic features of its dynamics. We thus present a transparent tool for studying the effects of drug intervention and ways of administration on cross-membrane signalling through these receptors.
authors.affiliation: Xenologiq Ltd, Unit 7, Denne Hill Business Park, Canterbury, Kent CT4 6HD, UK.
authors.forename: Neil
authors.initials: N
authors.lastname: Benson
authors.forename: Piet H
authors.initials: PH
authors.lastname: van der Graaf
authors.forename: Lambertus A
authors.initials: LA
authors.lastname: Peletier
mesh_terms: D002462:Cell Membrane / Q000201:enzymology; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D049490:Systems Biology
chemical_list: D008024:Ligands; D020794:Receptor Protein-Tyrosine Kinases