title: Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants.
abstract: Enteric infections are associated with linear growth failure in children. To quantify the association between intestinal inflammation and linear growth failure three commercially available enzyme-linked immunosorbent assays (neopterin [NEO], alpha-anti-trypsin [AAT], and myeloperoxidase [MPO]) were performed in a structured sampling of asymptomatic stool from children under longitudinal surveillance for diarrheal illness in eight countries. Samples from 537 children contributed 1,169 AAT, 916 MPO, and 954 NEO test results that were significantly associated with linear growth. When combined to form a disease activity score, children with the highest score grew 1.08 cm less than children with the lowest score over the 6-month period following the tests after controlling for the incidence of diarrheal disease. This set of affordable non-invasive tests delineates those at risk of linear growth failure and may be used for the improved assessments of interventions to optimize growth during a critical period of early childhood.
authors.forename: Margaret
authors.initials: M
authors.lastname: Kosek
authors.forename: Rashidul
authors.initials: R
authors.lastname: Haque
authors.forename: Aldo
authors.initials: A
authors.lastname: Lima
authors.forename: Sudhir
authors.initials: S
authors.lastname: Babji
authors.forename: Sanjaya
authors.initials: S
authors.lastname: Shrestha
authors.forename: Shahida
authors.initials: S
authors.lastname: Qureshi
authors.forename: Samie
authors.initials: S
authors.lastname: Amidou
authors.forename: Estomih
authors.initials: E
authors.lastname: Mduma
authors.forename: Gwenyth
authors.initials: G
authors.lastname: Lee
authors.forename: Pablo Peñataro
authors.initials: PP
authors.lastname: Yori
authors.forename: Richard L
authors.initials: RL
authors.lastname: Guerrant
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Bhutta
authors.forename: Carl
authors.initials: C
authors.lastname: Mason
authors.forename: Gagandeep
authors.initials: G
authors.lastname: Kang
authors.forename: Mamun
authors.initials: M
authors.lastname: Kabir
authors.forename: Caroline
authors.initials: C
authors.lastname: Amour
authors.forename: Pascal
authors.initials: P
authors.lastname: Bessong
authors.forename: Ali
authors.initials: A
authors.lastname: Turab
authors.forename: Jessica
authors.initials: J
authors.lastname: Seidman
authors.forename: Maribel Paredes
authors.initials: MP
authors.lastname: Olortegui
authors.forename: Josiane
authors.initials: J
authors.lastname: Quetz
authors.forename: Dennis
authors.initials: D
authors.lastname: Lang
authors.forename: Jean
authors.initials: J
authors.lastname: Gratz
authors.forename: Mark
authors.initials: M
authors.lastname: Miller
authors.forename: Michael
authors.initials: M
authors.lastname: Gottlieb
mesh_terms: D015415:Biomarkers / Q000032:analysis; D002675:Child, Preschool; D015331:Cohort Studies; D003906:Developing Countries; D003967:Diarrhea / Q000150:complications / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000737:chemistry*; D006130:Growth Disorders / Q000209:etiology / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000150:complications / Q000382:microbiology / Q000503:physiopathology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000503:physiopathology*; D016014:Linear Models; D008137:Longitudinal Studies; D044342:Malnutrition / Q000150:complications / Q000503:physiopathology; D019798:Neopterin / Q000032:analysis; D010539:Permeability; D009195:Peroxidase / Q000032:analysis; D011203:Poverty; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D015415:Biomarkers; D000515:alpha 1-Antitrypsin; D019798:Neopterin; D009195:Peroxidase