title: Reproducibility of linear array for human papillomavirus genotyping.
abstract: We conducted a Linear Array test/retest analysis using cytologic specimens from 198 women. A total of 67.2% of samples had the same human papillomavirus (HPV) types detected in both tests (type-specific positive agreement was 83.3% overall [Kappa = 0.9] and 86.8% for carcinogenic types [Kappa = 0.92]). Discordance was highest with a low hybridization signal strength. Overall, Linear Array was highly reproducible.
authors.affiliation: Division of Cancer Epidemiology and Genetics, NCI/NIH/DHHS, Bethesda, Maryland, USA. koshiolj@mail.nih.gov
authors.forename: Jill
authors.initials: J
authors.lastname: Koshiol
authors.forename: S Terence
authors.initials: ST
authors.lastname: Dunn
authors.forename: Joan L
authors.initials: JL
authors.lastname: Walker
authors.forename: Rosemary E
authors.initials: RE
authors.lastname: Zuna
authors.forename: Mark
authors.initials: M
authors.lastname: Schiffman
authors.forename: Mark E
authors.initials: ME
authors.lastname: Sherman
authors.forename: Michael A
authors.initials: MA
authors.lastname: Gold
authors.forename: Richard A
authors.initials: RA
authors.lastname: Allen
authors.forename: Roy
authors.initials: R
authors.lastname: Zhang
authors.forename: Sophia S
authors.initials: SS
authors.lastname: Wang
authors.forename: Nicolas
authors.initials: N
authors.lastname: Wentzensen
mesh_terms: D005260:Female; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity