title: Dynamic changes of cerebral-specific proteins in full-term newborns with hypoxic-ischemic encephalopathy.
abstract: The aim of this study was to observe the dynamic changes of serum brain-derived neurotrophic factor (BDNF), S-100B, and Tau proteins levels in full-term newborns with hypoxic-ischemic encephalopathy (HIE) and to discuss their significance in brain damage. Serum samples of 28 full-term newborns diagnosed with HIE and 20 controls were obtained in the first 24 h of life. Another serum samples were also taken, respectively, at 3 and 7 days of life in HIE group. The concentrations of BDNF, S-100B, and Tau proteins were measured by the enzyme-linked immunosorbent assay method. Mean concentrations of BDNF, S-100B, and Tau proteins among different time period and in different grades of HIE group were calculated and compared. Compared with the control group, serum BDNF and proteins S-100B levels in HIE group were significantly elevated in 24 h after birth (P < 0.05) and their concentrations were also significantly higher among patients with mod-severe HIE compared to those with mild HIE at 24 h and 7 days after asphyxia (P < 0.05). Regardless of whether mod-severe HIE or mild HIE, there were no significant difference of serum BDNF and proteins S-100B among the three different time periods. There was no difference in Tau protein levels between HIE group and control group, also no difference between mod-severe HIE group and mild HIE group. BDNF and proteins S-100B are up-regulated early in asphyxia neonates with HIE; and the released amount of BDNF and proteins S-100B from nerve center system correlate with the extent of encephalopathy.
authors.affiliation: Department of Pediatrics, NICU, Bethune International Peace Hospital, Shijiazhuang Hebei, 050082, China. liufanglafy@yahoo.com.cn
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Suyan
authors.initials: S
authors.lastname: Yang
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Du
authors.forename: Zhimei
authors.initials: Z
authors.lastname: Guo
mesh_terms: D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000175:diagnosis; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood* / Q000175:diagnosis; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D047929:Term Birth; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016875:tau Proteins / Q000097:blood*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D064568:S100 Calcium Binding Protein beta Subunit; D016875:tau Proteins