title: Involvement of autophagy in coronavirus replication.
abstract: Coronaviruses are single stranded, positive sense RNA viruses, which induce the rearrangement of cellular membranes upon infection of a host cell. This provides the virus with a platform for the assembly of viral replication complexes, improving efficiency of RNA synthesis. The membranes observed in coronavirus infected cells include double membrane vesicles. By nature of their double membrane, these vesicles resemble cellular autophagosomes, generated during the cellular autophagy pathway. In addition, coronavirus infection has been demonstrated to induce autophagy. Here we review current knowledge of coronavirus induced membrane rearrangements and the involvement of autophagy or autophagy protein microtubule associated protein 1B light chain 3 (LC3) in coronavirus replication.
authors.affiliation: Avian Viral Diseases, The Pirbright Institute, Compton Laboratory, High Street, Compton, Newbury, Berkshire, RG20 7NN, UK. helena.maier@pirbright.ac.uk
authors.forename: Helena J
authors.initials: HJ
authors.lastname: Maier
authors.forename: Paul
authors.initials: P
authors.lastname: Britton
mesh_terms: D000818:Animals; D001343:Autophagy; D002462:Cell Membrane / Q000378:metabolism / Q000821:virology; D017934:Coronavirus / Q000502:physiology*; D006801:Humans; D014779:Virus Replication