title: MicroRNAs in common human diseases.
abstract: MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that have attracted tremendous attention from the biological and biomedical research communities over the past decade. With over 1900 miRNAs discovered in humans to date, many of them have already been implicated in common human disorders. Facilitated by high-throughput genomics and bioinformatics in conjunction with traditional molecular biology techniques and animal models, miRNA research is now positioned to make the transition from laboratories to clinics to deliver profound benefits to public health. Herein, we overview the progress of miRNA research related to human diseases, as well as the potential for miRNA to becoming the next generation of diagnostics and therapeutics.
authors.affiliation: Benaroya Research Institute and Center for Liver Disease, Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA 98101, USA. yli@benaroyaresearch.org
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Kris V
authors.initials: KV
authors.lastname: Kowdley
mesh_terms: D000818:Animals; D019295:Computational Biology; D006801:Humans; D007154:Immune System Diseases / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D019636:Neurodegenerative Diseases / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D014777:Virus Diseases / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
chemical_list: D035683:MicroRNAs