title: TDP-43 toxicity and the usefulness of junk.
abstract: A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.
authors.affiliation: Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California, USA.
authors.forename: Shuying
authors.initials: S
authors.lastname: Sun
authors.forename: Don W
authors.initials: DW
authors.lastname: Cleveland
mesh_terms: D004268:DNA-Binding Proteins / Q000633:toxicity*; D012316:RNA Nucleotidyltransferases / Q000235:genetics / Q000502:physiology; D016601:RNA-Binding Proteins / Q000633:toxicity*
chemical_list: D004268:DNA-Binding Proteins; D016601:RNA-Binding Proteins; D012316:RNA Nucleotidyltransferases; C505387:RNA debranching enzyme Dbr1, S cerevisiae