title: New triterpenoids with cytotoxic activity from actinidia valvata.
abstract: Two new triterpenoids, 30-O-beta-D-glucopyranosyloxy-2alpha,3alpha,24-trihydroxyurs-12,18-diene-28-oic acid O-beta-D-glucopyranosyl ester (1) and 2alpha,3beta,3,30-tetrahydroxyurs-12,18-diene-28-oic acid O-beta-D-glucopyranosyl ester (2) were isolated from roots of Actinidia valvata Dunn. Their structures were elucidated by means of extensive spectroscopic studies. Both these two new compounds showed moderate cytotoxic activity in vitro against BEL-7402 and SMMC-7721 tumor cell line.
authors.affiliation: Department of Traditional Chinese Medicine, Changhai Hospital of Second Military Medical University, Shanghai 200433, China. lingchangquan@gmail.com.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Qu
authors.forename: Guo-Yin
authors.initials: GY
authors.lastname: Zheng
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Su
authors.forename: Hui-Qing
authors.initials: HQ
authors.lastname: Zhang
authors.forename: Yan-Long
authors.initials: YL
authors.lastname: Yang
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Xin
authors.forename: Chang-Quan
authors.initials: CQ
authors.lastname: Ling
mesh_terms: D029042:Actinidia / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D018517:Plant Roots / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D010936:Plant Extracts; D014315:Triterpenes