title: Adiponectin, interleukin-6, and cardiovascular disease risk factors are modified by a short-term yoga-based lifestyle intervention in overweight and obese men.
abstract: OBJECTIVE
  To investigate the effect of a short-term yoga-based lifestyle intervention on risk factors for cardiovascular disease (CVD) and markers of inflammation and endothelial function in overweight and obese men.
  
  
  METHODS
  Nonrandomized prospective lifestyle intervention study with pre-post design. SETTING AND LOCATION: Integral Health Clinic, an outpatient facility providing yoga-based lifestyle intervention programs for prevention and management of chronic diseases.
  
  
  METHODS
  Overweight and obese men (n=51) were enrolled in the study. Subjects who were physically unable to participate and those participating in other interventions were excluded from the study.
  
  
  METHODS
  A pretested intervention program including asanas (physical postures), pranayama (breathing exercises), group discussions, lectures, and individualized advice.
  
  
  METHODS
  The primary outcome measure was weight loss, and the secondary outcome measures were clinical and laboratory correlates of CVD risk, levels of interleukin-6 (IL-6), adiponectin, and endothelin-1 (ET-1).
  
  
  RESULTS
  Men (n=51, body mass index [BMI] 26.26±2.42 kg/m(2)) were enrolled and underwent a yoga-based lifestyle intervention for 10 days. Of 51 subjects, 30 completed the study. There was a significant reduction in weight from Baseline to Day 10 (74.60±7.98, 72.69±8.37 kg, p<0.001, respectively), BMI (26.26±2.42, 25.69±2.47 kg/m(2), p<0.001, respectively), and systolic BP (121.73±11.58, 116.73±9.00, p=0.042, respectively). There was a significant reduction in plasma IL-6 from Baseline to Day 10 (median 2.24 vs. 1.26 pg/mL, respectively, p=0.012). There was a significant increase in the plasma adiponectin from Baseline to Day 10 (median 4.95 vs. 6.26 μg/mL, respectively, p=0.014). Plasma ET-1 level remained unchanged.
  
  
  CONCLUSIONS
  These findings suggest that even a short-term yoga-based lifestyle intervention may be an important modality to reduce the risk for CVD as indicated by weight loss, reduction in systolic blood pressure, an increase in adiponectin, and decrease in IL-6 in overweight and obese men.
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Kumar
authors.initials: K
authors.lastname: Sarvottam
authors.forename: Dipti
authors.initials: D
authors.lastname: Magan
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Yadav
authors.forename: Nalin
authors.initials: N
authors.lastname: Mehta
authors.forename: Sushil C
authors.initials: SC
authors.lastname: Mahapatra
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000097:blood* / Q000517:prevention & control*; D019332:Endothelin-1 / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008019:Life Style; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000628:therapy*; D050177:Overweight / Q000097:blood* / Q000628:therapy*; D011446:Prospective Studies; D011674:Pulse; D012307:Risk Factors; D015013:Yoga / Q000523:psychology*; D055815:Young Adult
chemical_list: D052242:Adiponectin; D019332:Endothelin-1; D015850:Interleukin-6; D008074:Lipoproteins