title: Fluorescent nanothermometers provide controlled plasmonic-mediated intracellular hyperthermia.
abstract: OBJECTIVE
  This article demonstrates how controlled hyperthermia at the cellular level can be achieved.
  
  
  METHODS
  The method is based on the simultaneous intracellular incorporation of fluorescence nanothermometers (CdSe quantum dots) and metallic nanoheaters (gold nanorods).
  
  
  RESULTS
  Real-time spectral analysis of the quantum dot emission provides a detailed feedback about the intracellular thermal loading caused by gold nanorods excited at the plasmon frequency. Based on this approach, thermal dosimetry is assessed in such a way that the infrared laser (heating) power required to achieve catastrophic intracellular temperature increments in cancer cells is identified.
  
  
  CONCLUSIONS
  This pure optical method emerges as a new and promising guide for the development of infrared hyperthermia therapies with minimal invasiveness.
authors.affiliation: Fluorescence Imaging Group, Departamento de Física de Materiales, Facultad de Ciencias, Instituto Nicolás Cabrera, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
authors.forename: Laura Martínez
authors.initials: LM
authors.lastname: Maestro
authors.forename: Patricia
authors.initials: P
authors.lastname: Haro-González
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Iglesias-de la Cruz
authors.forename: Francisco
authors.initials: F
authors.lastname: Sanz-Rodríguez
authors.forename: Ángeles
authors.initials: Á
authors.lastname: Juarranz
authors.forename: José García
authors.initials: JG
authors.lastname: Solé
authors.forename: Daniel
authors.initials: D
authors.lastname: Jaque
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry; D002468:Cell Physiological Phenomena; D005334:Fever; D005453:Fluorescence; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D036103:Nanotechnology; D043942:Nanotubes / Q000737:chemistry; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry; D013821:Thermometers
chemical_list: D019187:Cadmium Compounds; D018036:Selenium Compounds; D006046:Gold; C058667:cadmium selenide