title: Taking a bite: endocytosis in the maintenance of the slit diaphragm.
abstract: In the kidney, the slit diaphragm joins adjacent podocytes, forming an epithelial barrier that filters plasma into the urinary space, yet retains blood cells and proteins within the circulation. In this issue of the JCI, Soda et al. have identified clathrin-mediated endocytosis as a central mechanism by which the function and structural integrity of the slit diaphragm are maintained.
authors.affiliation: Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.
authors.forename: Rosemary V
authors.initials: RV
authors.lastname: Sampogna
authors.forename: Qais
authors.initials: Q
authors.lastname: Al-Awqati
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000818:Animals; D034284:Dynamin I / Q000235:genetics*; D034285:Dynamin II / Q000235:genetics*; D060730:Glomerular Filtration Barrier / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D050199:Podocytes / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D009419:Nerve Tissue Proteins; C498434:Sh3gl2 protein, mouse; C097702:synaptojanin; D010744:Phosphoric Monoester Hydrolases; D034284:Dynamin I; D034285:Dynamin II