title: Liver transplant from an ABO-incompatible and hepatitis C antibody-positive but an HCV-RNA negative living donor in a familial amyloid polyneuropathy patient.
abstract: Familial amyloid polyneuropathy is a rare, progressively disabling, and ultimately fatal inherited disease. Liver transplant is currently the only available treatment proven to halt the progression of familial amyloid polyneuropathy. We report a 31-year-old woman with familial amyloid polyneuropathy who received a living-donor liver transplant from her husband who was hepatitis C virus antibody-positive but HCV-RNA negative and ABO incompatible. Six years after the transplant, both donor and recipient have normal liver biochemistry results; no hepatitis C viral load has been detectable in the recipient. This is the first report of a living ABO-incompatible liver transplant from an anti-hepatitis C virus antibody-positive but an HCV-RNA negative donor. This experience suggests that the use of an anti-hepatitis C virus antibody-positive hepatic graft is possible in select circumstances.
authors.affiliation: Department of Transplantation and Pediatric Surgery, Postgraduate School of Medical Science, Kumamoto University Hospital, 1-1-1 Honjo, Kumamoto, Japan. ttakeichi@fc.kuh.kumamoto-u.ac.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takeichi
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Asonuma
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ohya
authors.forename: Kenji
authors.initials: K
authors.lastname: Okumura
authors.forename: Kwang-Jong
authors.initials: KJ
authors.lastname: Lee
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Inomata
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D028227:Amyloid Neuropathies, Familial / Q000601:surgery*; D001787:Blood Group Incompatibility; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification; D006526:Hepatitis C / Q000175:diagnosis / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000097:blood*; D006650:Histocompatibility Testing; D006801:Humans; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D018454:Spouses; D016896:Treatment Outcome
chemical_list: D000017:ABO Blood-Group System; D018937:Hepatitis C Antibodies