title: The chemopreventive capacity of quercetin to induce programmed cell death in hepatocarcinogenesis.
abstract: In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60% with quercetin pretreatment compared with those rats treated with N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated with an abolished DEN-induced lipid peroxidation as well as activation of caspase 9 and increased caspase 3, as determined by increased expression of cleaved caspase 3 and 9, but not cleaved caspase 8 and increased fragmentation of Poly (ADP-ribose) polymerase (PARP) inducing apoptosis of presumed genetically injured cells, when quercetin was administered before the initiation agent.
authors.affiliation: Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del IPN, México D.F., México.
authors.forename: Verónica Rocío
authors.initials: VR
authors.lastname: Vásquez-Garzón
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Macias-Pérez
authors.forename: Mónica Noemí
authors.initials: MN
authors.lastname: Jiménez-García
authors.forename: Vanessa
authors.initials: V
authors.lastname: Villegas
authors.forename: Samia
authors.initials: S
authors.lastname: Fattel-Fazenta
authors.forename: Saúl
authors.initials: S
authors.lastname: Villa-Treviño
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D063646:Carcinogenesis / Q000187:drug effects; D020169:Caspases / Q000378:metabolism; D018890:Chemoprevention / Q000379:methods; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000737:chemistry / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D011230:Precancerous Conditions / Q000737:chemistry / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D011794:Quercetin; D020169:Caspases