title: Molecular participants in regulation of the meiotic cell cycle in mammalian oocytes.
abstract: Meiosis in oocytes consists of two consecutive asymmetric cell divisions, each completed by the extrusion of one set of chromosomes into a small polar body. First polar body (PBI) extrusion is triggered by the inactivation of cyclin-dependent kinase 1 (CDK1), following the degradation of its regulatory subunit cyclin B1 by the ubiquitin proteasome pathway. The present review covers the sequence of events leading to PBI extrusion, and compares them to the corresponding events in mitotic cell division. The latest findings regarding the contribution of ubiquitin chain topology, separase, securin, cyclin B1, CDK1, Polo-like kinase 1 and mitogen-activated protein kinase kinase 1/2 to the regulation of meiosis are discussed.
authors.affiliation: Department of Biological Regulation, The Weizmann Institute of Science, 234 Herzl St, Rehovot 76100, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Pomerantz
authors.forename: Nava
authors.initials: N
authors.lastname: Dekel
mesh_terms: D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D005260:Female; D006801:Humans; D008322:Mammals; D008540:Meiosis; D009865:Oocytes / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D009866:Oogenesis; D059705:Polar Bodies / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D016203:CDC2 Protein Kinase; D046988:Proteasome Endopeptidase Complex