title: Effect of zeolite nano-materials and artichoke (Cynara scolymus L.) leaf extract on increase in urinary clearance of systematically absorbed nicotine.
abstract: Nicotine, the main pharmacologically active component in tobacco and cigarette, has some toxic effects and also high potential for addiction. In this study, the effect of artichoke (Cynara scolymus L.) and zeolite nano-materials on urinary excretion of nicotine and consequently elimination of systematically absorbed nicotine was investigated. A simple, valid and highly sensitive high performance liquid chromatography method has been developed for determination of nicotine in rat urine according to guidelines for bioanalysis.It was found that nano-zeolites can cause increase in urinary concentration of nicotine due to its high surface adsorption. Artichoke leaf extract can cause increase in urinary excretion of nicotine in longer post administration times. It was observed that co-administration of nanozeolites and the leaf extract has the synergetic effect on increasing the urinary excretion of nicotine.
authors.affiliation: Department of Inorganic Chemistry, Razi University, Kermanshah, Iran.
authors.forename: R E
authors.initials: RE
authors.lastname: Malekshah
authors.forename: R
authors.initials: R
authors.lastname: Mahjub
authors.forename: M
authors.initials: M
authors.lastname: Rastgarpanah
authors.forename: M
authors.initials: M
authors.lastname: Ghorbani
authors.forename: A R
authors.initials: AR
authors.lastname: Partoazar
authors.forename: S E
authors.initials: SE
authors.lastname: Mehr
authors.forename: A R
authors.initials: AR
authors.lastname: Dehpour
authors.forename: F A
authors.initials: FA
authors.lastname: Dorkoosh
mesh_terms: D000818:Animals; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D031943:Cynara scolymus / Q000737:chemistry*; D007202:Indicators and Reagents; D057230:Limit of Detection; D053758:Nanoparticles; D009538:Nicotine / Q000493:pharmacokinetics* / Q000652:urine; D018722:Nicotinic Agonists / Q000493:pharmacokinetics* / Q000652:urine; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D017641:Zeolites / Q000494:pharmacology*
chemical_list: D007202:Indicators and Reagents; D018722:Nicotinic Agonists; D010936:Plant Extracts; D017641:Zeolites; D009538:Nicotine