title: Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.
abstract: Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ishiguro
authors.forename: Azusa
authors.initials: A
authors.lastname: Takahashi-Nakaguchi
authors.forename: Jane
authors.initials: J
authors.lastname: Fromont
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001854:Bone Marrow Cells / Q000166:cytology; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005227:Fatty Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007192:Indenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018664:Interleukin-12 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007564:Japan; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008810:Mice, Inbred C57BL; D008968:Molecular Conformation; D047229:Plakortis / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D005227:Fatty Acids; D007192:Indenes; D015850:Interleukin-6; D061065:Polyketides; D014409:Tumor Necrosis Factor-alpha; C581251:manzamenone L; C581252:manzamenone M; C581253:manzamenone N; D018664:Interleukin-12