title: Bone complications of mastocytosis: a link between clinical and biological characteristics.
abstract: OBJECTIVE
  Mastocytosis is a heterogeneous group of clonal mast cell disorders in which bone manifestations are frequently seen, but poorly understood. In this study, we analyzed correlation of clinical findings in mastocytosis patients with bone mineral density and bone turnover markers.
  
  
  METHODS
  Serum levels of bone turnover markers were measured in mastocytosis patients and healthy volunteers. Bone disease was evaluated using radiographic imaging, and measurement of bone mineral density.
  
  
  RESULTS
  Of 45 adult mastocytosis patients, bone abnormalities were detected in 34 (75%). Bone lesions were documented on radiographic imaging in 16 patients (36%), and bone mineral density in 24 patients (53%), of which 9 patients (20%) had osteoporosis and 15 (33%) had osteopenia. Serum levels of bone turnover markers that evaluate bone resorption (C-telopeptide, deoxypyridinoline), bone formation (bone-specific alkaline phosphatase), and bone remodeling (osteoprotegerin) were significantly higher in the patient population than in the control population (n=28). Levels of C-telopeptide and osteoprotegerin were higher in patients with advanced systemic mastocytosis than in patients with cutaneous or indolent systemic mastocytosis. Moreover, C-telopeptide and osteoprotegerin levels were significantly correlated with those of serum tryptase, a diagnostic marker of mastocytosis.
  
  
  CONCLUSIONS
  The observed bone turnover markers variations indicate a complex process of bone turnover in mastocytosis-related bone manifestations. The highly significant correlation between serum tryptase and serum bone turnover markers levels, and the positive correlation of levels of bone turnover markers with advanced disease, support the existence of a link between bone remodeling and mast cell burden.
authors.affiliation: Department of Biology, University Hospital, Amiens, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Guillaume
authors.forename: Judith
authors.initials: J
authors.lastname: Desoutter
authors.forename: Olivia
authors.initials: O
authors.lastname: Chandesris
authors.forename: Lavinia
authors.initials: L
authors.lastname: Merlusca
authors.forename: Isabelle
authors.initials: I
authors.lastname: Henry
authors.forename: Sophie
authors.initials: S
authors.lastname: Georgin-Lavialle
authors.forename: Stéphane
authors.initials: S
authors.lastname: Barete
authors.forename: Isabelle
authors.initials: I
authors.lastname: Hirsch
authors.forename: Daoud
authors.initials: D
authors.lastname: Bouredji
authors.forename: Bruno
authors.initials: B
authors.lastname: Royer
authors.forename: Bérengère
authors.initials: B
authors.lastname: Gruson
authors.forename: Catherine
authors.initials: C
authors.lastname: Lok
authors.forename: Henri
authors.initials: H
authors.lastname: Sevestre
authors.forename: Romuald
authors.initials: R
authors.lastname: Mentaverri
authors.forename: Michel
authors.initials: M
authors.lastname: Brazier
authors.forename: Jonathan
authors.initials: J
authors.lastname: Meynier
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Marolleau
authors.forename: Said
authors.initials: S
authors.lastname: Kamel
authors.forename: Gandhi
authors.initials: G
authors.lastname: Damaj
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D016723:Bone Remodeling; D005260:Female; D006801:Humans; D008297:Male; D008415:Mastocytosis / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D012189:Retrospective Studies; D053802:Tryptases / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D053802:Tryptases