title: Prevalence and associations of the use of proton-pump inhibitors in nursing homes: a cross-sectional study.
abstract: OBJECTIVE
  Very scarce information is available about the use of proton-pump inhibitors (PPI) in nursing homes (NH). This study investigated the factors associated with PPI use among NH residents.
  
  
  METHODS
  Cross-sectional
  
  
  METHODS
  One hundred seventy-five NHs in Midi-Pyrénées region, South-Western France.
  
  
  METHODS
  Data was collected for 6275 NH residents. Participants (73.7% women) were aged 86 years (± 8.2).
  
  
  METHODS
  NH staff sent participants' drug prescriptions to research team; they also recorded information on residents' health characteristics. A binary logistic regression was performed on PPI use.
  
  
  RESULTS
  PPI use was highly prevalent (n = 2 370, ie, 37.8%). Whilst peptic ulcer (OR 4.741; 95% CI 3.647-6.163) and nonsteroidal anti-inflammatory drugs (OR 2.124; 95% CI 1.528-2.951) were important indicators of PPI use, they explained just a small fraction of PPI prescriptions; most prescriptions were probably inappropriately related to a general condition of health vulnerability, reflected by polypharmacy and comorbidities.
  
  
  CONCLUSIONS
  Vulnerable people take PPIs more often in NHs. Physicians must be aware about the health risks possibly induced by inappropriate PPI use when prescribing these drugs for NH residents.
authors.affiliation: Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France. philipebarreto81@yahoo.com.br
authors.forename: Philipe
authors.initials: P
authors.lastname: de Souto Barreto
authors.forename: Maryse
authors.initials: M
authors.lastname: Lapeyre-Mestre
authors.forename: Céline
authors.initials: C
authors.lastname: Mathieu
authors.forename: Christine
authors.initials: C
authors.lastname: Piau
authors.forename: Catherine
authors.initials: C
authors.lastname: Bouget
authors.forename: Françoise
authors.initials: F
authors.lastname: Cayla
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
authors.forename: Yves
authors.initials: Y
authors.lastname: Rolland
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D017723:Drug Utilization Review; D005260:Female; D005764:Gastroesophageal Reflux / Q000139:chemically induced; D015577:Geriatric Assessment / Q000706:statistics & numerical data*; D006304:Health Status; D006801:Humans; D057970:Inappropriate Prescribing / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009735:Nursing Homes / Q000706:statistics & numerical data*; D010437:Peptic Ulcer / Q000139:chemically induced; D019338:Polypharmacy; D015995:Prevalence; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D014481:United States / Q000453:epidemiology
chemical_list: D054328:Proton Pump Inhibitors