title: [Correlationship between chemokines and oxidative stress in chronic hepatitis B].
abstract: OBJECTIVE
  The aim of this study is to investigate the possible associations of chemokines IP-10, Rantes and oxidative stress in chronic hepatits B (CHB).
  
  
  METHODS
  70 CHB patients and 10 healthy controls were enrolled in the study. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of IFN-gamma-inducible protein-10 (IP-10) and regulated on activation normal T-cell-expressed and secreted (Rantes) and oxidative stress parameters (glutathione, GSH; glutathione disulfide, GSSG). Correlationship were analyzed by Spearman's rank correlation.
  
  
  RESULTS
  The levels of IP-10 and Rantes were higher in CHB patients than healthy controls, and strong positive associations were found between IP-10/Rantes and alanine aminotransferase (ALT). The levels of GSH and GSH/GSSG were lower in CHB patients than healthy controls, and GSH and GSH/GSSG were negatively correlated with ALT. The levels of IP-10 and Rantes were negatively correlated with GSH and GSH/GSSG respectively.
  
  
  CONCLUSIONS
  Strong associations were found between chemokines and oxidative stress which participated in the pathogenesis of CHB.
authors.affiliation: Department of Infection, Linyi People's Hospital, Linyi 276003, China.
authors.forename: Jing-Wei
authors.initials: JW
authors.lastname: Wang
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Wang
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Zhao
authors.forename: Cheng-Bao
authors.initials: CB
authors.lastname: Wang
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Huang
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D018946:Chemokine CCL5 / Q000097:blood*; D054357:Chemokine CXCL10 / Q000097:blood*; D005260:Female; D005978:Glutathione / Q000097:blood; D019803:Glutathione Disulfide / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000097:blood / Q000378:metabolism* / Q000821:virology; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: C483024:CCL5 protein, human; C114753:CXCL10 protein, human; D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D008315:Malondialdehyde; D000410:Alanine Transaminase; D005978:Glutathione; D019803:Glutathione Disulfide