title: Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes.
abstract: A series of Ru(II) catalysts inspired by the metalloenzyme nitrile hydratase catalyze the hydration of benzonitrile with up to 242 turnovers under neutral conditions with very low catalysts loading. Catalysts with an oxidized sulfur environment are less susceptible to product inhibition increasing the catalytic efficiency at low nitrile : water ratios.
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
authors.forename: Davinder
authors.initials: D
authors.lastname: Kumar
authors.forename: César A
authors.initials: CA
authors.lastname: Masitas
authors.forename: Tho N
authors.initials: TN
authors.lastname: Nguyen
authors.forename: Craig A
authors.initials: CA
authors.lastname: Grapperhaus
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D006836:Hydro-Lyases / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D009570:Nitriles / Q000737:chemistry*; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D056831:Coordination Complexes; D009570:Nitriles; D013438:Sulfhydryl Compounds; D013455:Sulfur; D012428:Ruthenium; C014356:benzonitrile; D006836:Hydro-Lyases; C048831:nitrile hydratase