title: Adipose tissue regeneration: a state of the art.
abstract: Adipose tissue pathologies and defects have always represented a reconstructive challenge for plastic surgeons. In more recent years, several allogenic and alloplastic materials have been developed and used as fillers for soft tissue defects. However, their clinical use has been limited by further documented complications, such as foreign-body reactions potentially affecting function, degradation over time, and the risk for immunogenicity. Tissue-engineering strategies are thus being investigated to develop methods for generating adipose tissue. This paper will discuss the current state of the art in adipose tissue engineering techniques, exploring the biomaterials used, stem cells application, culture strategies, and current regulatory framework that are in use are here described and discussed.
authors.affiliation: Casadei Clinic, Via Olimpia 9, Mestre, 30174 Venezia, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Casadei
authors.forename: Roberta
authors.initials: R
authors.lastname: Epis
authors.forename: Letizia
authors.initials: L
authors.lastname: Ferroni
authors.forename: Ilaria
authors.initials: I
authors.lastname: Tocco
authors.forename: Chiara
authors.initials: C
authors.lastname: Gardin
authors.forename: Eriberto
authors.initials: E
authors.lastname: Bressan
authors.forename: Stefano
authors.initials: S
authors.lastname: Sivolella
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Vindigni
authors.forename: Paolo
authors.initials: P
authors.lastname: Pinton
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mucci
authors.forename: Barbara
authors.initials: B
authors.lastname: Zavan
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000502:physiology*; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D044968:Regenerative Medicine; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials