title: Mitochondrial heme: an exit strategy at last.
abstract: The transport of heme across membranes is critical for iron absorption, the formation of hemoglobin and other hemoproteins, and iron recycling in macrophages. However, the identity of heme transport proteins has been elusive. In this issue of the JCI, Chiabrando et al. reveal that an isoform of the feline leukemia virus subgroup C receptor (FLVCR1) exports heme from the mitochondria and is critical for erythroid differentiation.
authors.affiliation: Department of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. mark.fleming@childrens.harvard.edu
authors.forename: Mark D
authors.initials: MD
authors.lastname: Fleming
authors.forename: Iqbal
authors.initials: I
authors.lastname: Hamza
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004912:Erythrocytes / Q000502:physiology*; D006801:Humans; D026901:Membrane Transport Proteins / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000502:physiology*; D011991:Receptors, Virus / Q000502:physiology*
chemical_list: C492690:FLVCR1 protein, human; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D011991:Receptors, Virus