title: Are vigabatrin induced T2 hyperintensities in cranial MRI associated with acute encephalopathy and extrapyramidal symptoms?
abstract: Reversible T2-hyperintensities in cranial MRI have been recently observed in infants with infantile spasms, who were treated with vigabatrin. In most cases, this phenomenon is solely been reported in neuroimaging practice without clinical relevance. We report two patients with infantile spasms, who not only developed transient T2-hyperintensities, but also presented acute encephalopathy, and extrapyramidal symptoms under vigabatrin therapy.
authors.affiliation: Division of Pediatric Neurology and Developmental Medicine, University Children's Hospital, University of Basel, Spitalstrasse 33, Basel, Switzerland. patricia.dill@ukbb.ch
authors.forename: Patricia
authors.initials: P
authors.lastname: Dill
authors.forename: Alexandre N
authors.initials: AN
authors.lastname: Datta
authors.forename: Peter
authors.initials: P
authors.lastname: Weber
authors.forename: Jacques
authors.initials: J
authors.lastname: Schneider
mesh_terms: D000208:Acute Disease; D000927:Anticonvulsants / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000209:etiology*; D004314:Down Syndrome / Q000175:diagnosis; D004421:Dystonia / Q000209:etiology*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012886:Skull / Q000473:pathology; D013036:Spasms, Infantile / Q000188:drug therapy*; D016896:Treatment Outcome; D020888:Vigabatrin / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D020888:Vigabatrin