title: Catalytic enantioselective desymmetrisation as a tool for the synthesis of hodgkinsine and hodgkinsine B.
abstract: Two palladium-catalysed amination protocols are deployed in the desymmetrisation of the complex dimeric alkaloid meso-chimonanthine. The power of these transformations is showcased in an efficient formal and total synthesis of the natural products hodgkinsine and hodgkinsine B, respectively.
authors.affiliation: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, UK.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Snell
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Durbin
authors.forename: Robert L
authors.initials: RL
authors.lastname: Woodward
authors.forename: Michael C
authors.initials: MC
authors.lastname: Willis
mesh_terms: D000586:Amination; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D011758:Pyrroles; C077369:hodgkinsine; D010165:Palladium; C521484:chimonanthine