title: Three cases of an unusual pattern of invasion in malignant Brenner tumors.
abstract: Ovarian malignant Brenner tumors are rare neoplasms that are typically admixed with benign and borderline Brenner tumor elements. We report 3 cases of an unusual variant of malignant Brenner tumor where the infiltrative malignant component arose directly from a benign Brenner tumor rather than from borderline elements and did not exhibit a desmoplastic stromal response. Borderline elements were present in 1 case, but the invasive component did not arise from these. Our cases highlight that an absence of a borderline element should not dissuade the pathologist from diagnosing a malignant Brenner tumor.
authors.affiliation: Birmingham Women's NHS Foundation Trust, Birmingham, UK.
authors.forename: Kelvin
authors.initials: K
authors.lastname: St Pierre-Robson
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dunn
authors.forename: Edwin
authors.initials: E
authors.lastname: Cooper
authors.forename: Nasima
authors.initials: N
authors.lastname: Tofazzal
authors.forename: Lynn
authors.initials: L
authors.lastname: Hirschowitz
authors.forename: W Glenn
authors.initials: WG
authors.lastname: McCluggage
authors.forename: Raji
authors.initials: R
authors.lastname: Ganesan
mesh_terms: D001948:Brenner Tumor / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*