title: Medical management of vascular anomalies.
abstract: The term "vascular anomalies" embraces a spectrum of medical conditions characterized by abnormal growth or development of blood and/or lymphatic vessels. Patient management is frequently provided in a multidisciplinary team approach, as there are many facets to evaluation and treatment. Clinical and basic research during the past decade has enhanced our knowledge, providing insight into possible etiologies, associated genetic mutations, cellular mechanisms modulating the development, and natural history of these disorders. Concomitantly, new therapeutic agents have been identified, which has transformed patient management. In this review, a brief overview of the field including an update in basic research is presented, followed by a discussion of current therapies and their purported mechanism of action.
authors.affiliation: Vascular Birthmark Institute of New York, New York, New York 10023, USA. fblei@chpnet.org
authors.forename: Francine
authors.initials: F
authors.lastname: Blei
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D006390:Hemangioendothelioma / Q000188:drug therapy; D006391:Hemangioma / Q000188:drug therapy; D006801:Humans; D059885:Kasabach-Merritt Syndrome / Q000188:drug therapy; D011433:Propranolol / Q000627:therapeutic use; D012514:Sarcoma, Kaposi / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy; D054079:Vascular Malformations / Q000188:drug therapy*
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol