title: αKlotho: FGF23 coreceptor and FGF23-regulating hormone.
abstract: Low levels of phosphate can disrupt bone ossification and predispose to fractures. FGF23 is one of the major determinants of phosphate homeostasis, acting to increase urinary phosphate excretion. However, the regulation of FGF23 is incompletely understood. In this issue of the JCI, Smith et al. show that the cleaved form of αKlotho, the membrane-bound form of which is an FGF23 coreceptor, serves as a novel endocrine regulator of phosphate homeostasis, capable of inducing FGF23 production in osteocytes.
authors.affiliation: Endocrine Unit and Pediatric Nephrology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. hjueppner@partners.org
authors.forename: Harald
authors.initials: H
authors.lastname: Jüppner
authors.forename: Myles
authors.initials: M
authors.lastname: Wolf
mesh_terms: D000818:Animals; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005966:Glucuronidase; D000090265:Klotho Proteins; D010710:Phosphates / Q000097:blood*; D011956:Receptors, Cell Surface / Q000097:blood*
chemical_list: D010710:Phosphates; D011956:Receptors, Cell Surface; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins