title: The effect of two different parenteral nutrition regimens on parenteral nutrition-associated cholestasis.
abstract: Exposure to parenteral nutrition (PN) is one major factor in the development of cholestasis. The aim of this retrospective study was to compare the effect of these two different PN regimens on PN-associated cholestasis (PNAC). The files of the patients who have received different PN regimens for >14 d in 2005 and 2009 were retrospectively reviewed. 133 patients have received PN more than 14 d. 22 (16.5%) patients had PNAC. 90 neonates were in Group low-dose parenteral (LDpn) and 43 neonates in Group high-dose parenteral. Mean gestational age and birth weight were statistically significantly lower in LDpn Group (p = 0.016, p = 0.434). Cholestasis rate was significantly higher in high dose group. (p = 0.023). Although several risk factors for PNAC are unavoidable, research is still needed to define the optimal parenteral amino acid solution for neonatal patients. Individualized PN may be more affective in allowing growth and minimizing side effects.
authors.affiliation: Department of Neonatology, Çukurova University, Adana, Turkey. ferdaozlu72@yahoo.com
authors.forename: Ferda
authors.initials: F
authors.lastname: Ozlü
authors.forename: Prof Hacer
authors.initials: PH
authors.lastname: Yapıcıoğlu
authors.forename: Kurthan
authors.initials: K
authors.lastname: Mer
authors.forename: Mehmet
authors.initials: M
authors.lastname: Satar
authors.forename: Nejat
authors.initials: N
authors.lastname: Narlı
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Sertdemir
mesh_terms: D002779:Cholestasis / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal; D010288:Parenteral Nutrition / Q000009:adverse effects*; D057947:Parenteral Nutrition Solutions / Q000008:administration & dosage*; D012189:Retrospective Studies
chemical_list: D057947:Parenteral Nutrition Solutions