title: Detection of cancer using advanced computerized analysis of infrared spectra of peripheral blood.
abstract: We have developed a novel approach for detection of cancer based on biochemical analysis of peripheral blood plasma using Fourier transform infrared spectroscopy. This approach has proven to be quick, safe, minimal invasive, and effective. Our approach recognizes any signs of solid tumor presence, regardless of location in the body or cancer type by measuring a spectrum that gives information regarding the total molecular composition and structure of the peripheral blood samples. The analysis includes clinically relevant preprocessing and feature extraction with principal component analysis, and uses Fisher's linear discriminant analysis to classify between cancer patients and healthy controls. We evaluated our method with leave-one-out cross validation and were able to establish sensitivity of 93.33%, specificity of 87.8%, and overall accuracy of 90.7%. Using our method for cancer detection should result in fewer unnecessary invasive procedures and yield fast detection of solid tumors.
authors.affiliation: Department of Biomedical Engineering, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel. ela@todosmedical.com
authors.forename: Ela
authors.initials: E
authors.lastname: Ostrovsky
authors.forename: Udi
authors.initials: U
authors.lastname: Zelig
authors.forename: Irina
authors.initials: I
authors.lastname: Gusakova
authors.forename: Samuel
authors.initials: S
authors.lastname: Ariad
authors.forename: Shaul
authors.initials: S
authors.lastname: Mordechai
authors.forename: Ilana
authors.initials: I
authors.lastname: Nisky
authors.forename: Joseph
authors.initials: J
authors.lastname: Kapilushnik
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood / Q000737:chemistry; D016022:Case-Control Studies; D016002:Discriminant Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009010:Monte Carlo Method; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis; D025341:Principal Component Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor