title: The therapeutic effects of melatonin and nimodipine in rats after cerebral cortical injury.
abstract: OBJECTIVE
  Secondary brain injury starts after the initial traumatic impact and marked by an increase in the intracellular calcium concentrations.This cascadeeventually results in membrane lipid peroxidation and neuronal cell death.
  
  
  METHODS
  We investigated the neuro-protective effects of nimodipine and melatonin in 38 rats after 6 hours of head trauma using the cortical impact injury model of Marmarou.
  
  
  RESULTS
  Brain water in the melatonin-given group decreased significantly comparing to that of control group the brain water in the nimodipine given group increased significantly comparing to that of trauma group. Histopathologically, brain edema was significantly low in melatonin-administered group comparing to that of control group while there were no changes in brain edema in the nimodipine given group and in the group that both nimodipine and melatonin were administered in combination. MDA levels in the brain tissues were significantly lower in the melatonin and nimodipine groups comparing to those of trauma and control group however this difference was by far significant in melatonin group comparing to nimodipine group.
  
  
  CONCLUSIONS
  Melatonin appears to have neuro-protective effects on the secondary brain damage while nimodipine and nimodipine plus melatonin combination did not show such neuro-protective effects on the secondary brain injury.
authors.affiliation: Suleyman Demirel University, Medical Faculty Hospital, Department of Neurosurgery, Isparta, Turkey. ozguri_36@hotmail.com
authors.forename: Ozgur
authors.initials: O
authors.lastname: Ismailoglu
authors.forename: Pergin
authors.initials: P
authors.lastname: Atilla
authors.forename: Selcuk
authors.initials: S
authors.lastname: Palaoglu
authors.forename: Nur
authors.initials: N
authors.lastname: Cakar
authors.forename: Umit
authors.initials: U
authors.lastname: Yasar
authors.forename: Kamer
authors.initials: K
authors.lastname: Kilinc
authors.forename: Erkan
authors.initials: E
authors.lastname: Kaptanoglu
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D001929:Brain Edema / Q000188:drug therapy*; D001930:Brain Injuries / Q000188:drug therapy*; D004195:Disease Models, Animal; D004338:Drug Combinations; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009553:Nimodipine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004338:Drug Combinations; D018696:Neuroprotective Agents; D009553:Nimodipine; D008550:Melatonin