title: Microfluidic assisted self-assembly of chitosan based nanoparticles as drug delivery agents.
abstract: We present a microfluidic platform for the synthesis of monodisperse chitosan based nanoparticles via self-assembly at physiological pH. The resultant nanoparticles are shown to encapsulate hydrophobic anticancer drugs while providing a sustainable release profile with high tunability.
authors.affiliation: Laboratoire de Microsystemes (LMIS4), École Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland.
authors.forename: Fatemeh Sadat
authors.initials: FS
authors.lastname: Majedi
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Hasani-Sadrabadi
authors.forename: Shahriar Hojjati
authors.initials: SH
authors.lastname: Emami
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Shokrgozar
authors.forename: Jules John
authors.initials: JJ
authors.lastname: VanDersarl
authors.forename: Erfan
authors.initials: E
authors.lastname: Dashtimoghadam
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bertsch
authors.forename: Philippe
authors.initials: P
authors.lastname: Renaud
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry; D010316:Particle Size
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D048271:Chitosan; D017239:Paclitaxel