title: Novel galanin receptor subtype specific ligand in depression like behavior.
abstract: Neuropeptide galanin and its three receptors, galanin receptor type 1-galanin receptor type 3, are known to be involved in the regulation of numerous psychological processes, including depression. Studies have suggested that stimulation of galanin receptor type 2 (GalR2) leads to attenuation of the depression-like behavior in animals. However, due to the lack of highly selective galanin subtype specific ligands the involvement of different receptors in depression-like behavior is yet not fully known. In the present study we introduce a novel GalR2 selective agonist and demonstrate its ability to produce actions consistent with theorized GalR2 functions and analogous to that of the anti-depressant, imipramine.
authors.affiliation: Institute of Technology, University of Tartu, Tartu, Estonia. indrek_saar@hotmail.com
authors.forename: Indrek
authors.initials: I
authors.lastname: Saar
authors.forename: Johan
authors.initials: J
authors.lastname: Runesson
authors.forename: Jaak
authors.initials: J
authors.lastname: Järv
authors.forename: Kaido
authors.initials: K
authors.lastname: Kurrikoff
authors.forename: Ulo
authors.initials: U
authors.lastname: Langel
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism* / Q000627:therapeutic use*; D016466:CHO Cells; D045744:Cell Line, Tumor; D006224:Cricetinae; D003412:Cricetulus; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism* / Q000523:psychology; D005260:Female; D019004:Galanin / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011485:Protein Binding / Q000502:physiology; D011897:Random Allocation; D044092:Receptor, Galanin, Type 2 / Q000819:agonists / Q000378:metabolism*
chemical_list: D000928:Antidepressive Agents; D008024:Ligands; D044092:Receptor, Galanin, Type 2; D019004:Galanin