title: The α2δ subunits of voltage-gated calcium channels.
abstract: Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together, except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which are collectively termed auxiliary or accessory subunits. This review will concentrate on the properties and role of the α2δ subunits of these channels. These proteins are largely extracellular, membrane-associated proteins which influence the trafficking, localization, and biophysical properties of the channels. This article is part of a Special Issue entitled: Calcium channels.
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, UK. a.dolphin@ucl.ac.uk
authors.forename: Annette C
authors.initials: AC
authors.lastname: Dolphin
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D021122:Protein Subunits
chemical_list: C425903:CACNA2D1 protein, human; C512066:CACNA2D1 protein, mouse; D015220:Calcium Channels; D021122:Protein Subunits; D002118:Calcium