title: Post-subarachnoid hemorrhage vasospasm in patients with primary headache disorders.
abstract: BACKGROUND
  Altered cerebral vasomotor reactivity leading to vasospasm can be seen both in patients with primary headache disorders (PHD) and in patients with subarachnoid hemorrhage (SAH). The pathogenesis of vasospasm in post-SAH patients and in headache disorder sufferers may be related. To address this hypothesis, we analyzed a large cohort of SAH patients to determine whether a diagnosis of PHD predisposes to vasospasm, delayed cerebral ischemia, or worsened clinical outcome.
  
  
  METHODS
  Prospectively collected data from patients enrolled in the SAH Outcomes Project between 1996 and 2006 were analyzed. Patients were segregated based on whether they had a diagnosis of PHD or not and were subsequently compared for differences in clinical and radiographic outcome.
  
  
  RESULTS
  A total of 921 SAH patients were analyzed, 265 of which had a diagnosis of PHD. In total, symptomatic vasospasm was seen in 17%, while angiographic vasospasm was seen in 28%. Vasospasm rates were similar among patients with a PHD and in those without a PHD (p > 0.05). However, on multivariate analysis new ischemic infarcts were more common in patients with a PHD as compared to patients without a PHD (p = 0.015). Functional outcomes at 3 months were similar among PHD and non-PHD patients (p > 0.05).
  
  
  CONCLUSIONS
  A history of PHD is associated with an increased rate of ischemic infarcts during admission for SAH. Increased rates of vasospasm within small cerebral blood vessels may be implicated. Further studies are warranted to more closely link the mechanisms of vasospasm in PHD and SAH patients.
authors.affiliation: Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA. jae2109@columbia.edu
authors.forename: Jason A
authors.initials: JA
authors.lastname: Ellis
authors.forename: Hannah
authors.initials: H
authors.lastname: Goldstein
authors.forename: Philip M
authors.initials: PM
authors.lastname: Meyers
authors.forename: Sean D
authors.initials: SD
authors.lastname: Lavine
authors.forename: E Sander
authors.initials: ES
authors.lastname: Connolly
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Mayer
authors.forename: Neeraj
authors.initials: N
authors.lastname: Badjatia
authors.forename: Dorothea
authors.initials: D
authors.lastname: Altschul
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000209:etiology* / Q000503:physiopathology; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000209:etiology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D051270:Headache Disorders, Primary / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000503:physiopathology; D020301:Vasospasm, Intracranial / Q000209:etiology* / Q000503:physiopathology