title: Rings in the extreme: PCNA interactions and adaptations in the archaea.
abstract: Biochemical and structural analysis of archaeal proteins has enabled us to gain great insight into many eukaryotic processes, simultaneously offering fascinating glimpses into the adaptation and evolution of proteins at the extremes of life. The archaeal PCNAs, central to DNA replication and repair, are no exception. Characterisation of the proteins alone, and in complex with both peptides and protein binding partners, has demonstrated the diversity and subtlety in the regulatory role of these sliding clamps. Equally, studies have provided valuable detailed insight into the adaptation of protein interactions and mechanisms that are necessary for life in extreme environments.
authors.affiliation: Centre for Biomolecular Sciences, University of Nottingham, University Park, UK. jody.winter@nottingham.ac.uk
authors.forename: Jody A
authors.initials: JA
authors.lastname: Winter
authors.forename: Karen A
authors.initials: KA
authors.lastname: Bunting
mesh_terms: D000220:Adaptation, Biological; D001105:Archaea / Q000235:genetics* / Q000502:physiology; D019843:Archaeal Proteins / Q000235:genetics* / Q000378:metabolism; D004260:DNA Repair; D004261:DNA Replication; D019143:Evolution, Molecular; D008958:Models, Molecular; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics* / Q000378:metabolism
chemical_list: D019843:Archaeal Proteins; D018809:Proliferating Cell Nuclear Antigen