title: Atractylodis Rhizoma extract and its component, atractylon, inhibit tumor promotion in mouse skin two-stage carcinogenesis.
abstract: The methanol extract of Atractylodis Rhizoma, a traditional Chinese medicine, was found to have antitumor-promoting activity in two-stage carcinogenesis. From the active fraction of the extract, atractylon was isolated. The isolated compound showed inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation in mice. Furthermore, atractylon markedly inhibited tumor promotion by TPA following 7,12-dimethylbenz[a]anthracene initiation in mice.
authors.affiliation: College of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi-shi, Chiba 274, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yu
authors.forename: K
authors.initials: K
authors.lastname: Yasukawa
authors.forename: M
authors.initials: M
authors.lastname: Takido