title: The relationship between changes in functional cardiac parameters following anthracycline therapy and carbonyl reductase 3 and glutathione S transferase Pi polymorphisms.
abstract: The aim of this prospective clinical study is to evaluate the relationship between changes in functional cardiac parameters following anthracycline therapy and carbonyl reductase 3 (CBR3p.V244M) and glutathione S transferase Pi (GSTP1p.I105V) polymorphisms. Seventy patients with normal  cardiac function and no history of cardiac disease scheduled to undergo anthracycline chemotherapy were included in the study. The patients' cardiac function was evaluated by gated blood pool scintigraphy and echocardiography before and after chemotherapy, as well as 1 year following  therapy. Gene polymorphisms were genotyped in 70 patients using TaqMan probes, validated by DNA sequencing. A deteriorating trend was observed in both systolic and diastolic parameters from GG to AA in CBR3p.V244M polymorphism. Patients with G-allele carriers of GSTP1p.I105V polymorphism  were common (60%), with significantly decreased PFR compared to patiens with AA genotype. Variants of CBR3 and GSTP1 enzymes may be associated with changes in short-term functional cardiac parameters.
authors.affiliation: Department of Nuclear Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey. bilgev@hacettepe.edu.tr
authors.forename: Bilge
authors.initials: B
authors.lastname: Volkan-Salanci
authors.forename: Hakan
authors.initials: H
authors.lastname: Aksoy
authors.forename: Pınar Özgen
authors.initials: PÖ
authors.lastname: Kiratli
authors.forename: Erol
authors.initials: E
authors.lastname: Tülümen
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Güler
authors.forename: Berna
authors.initials: B
authors.lastname: Öksüzoglu
authors.forename: Lale
authors.initials: L
authors.lastname: Tokgözoğlu
authors.forename: Belkıs
authors.initials: B
authors.lastname: Erbaş
authors.forename: Mehmet
authors.initials: M
authors.lastname: Alikaşifoğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000429:Alcohol Oxidoreductases / Q000235:genetics*; D018943:Anthracyclines / Q000009:adverse effects* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000235:genetics; D005260:Female; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D018943:Anthracyclines; D000970:Antineoplastic Agents; D000429:Alcohol Oxidoreductases; C531130:CBR3 protein, human; D051549:Glutathione S-Transferase pi