title: Effect of multinuclear copper/aluminum complexes in highly asymmetric conjugate addition of trimethylaluminum to acyclic enones.
abstract: Al and friends: asymmetric conjugate addition of Me(3)Al to β,β-disubstituted α,β-unsaturated ketones in the presence copper and L1 leads to a highly efficient construction of an all-carbon-substituted chiral quaternary center. This result is the first example of an asymmetric conjugate addition of Me(3)Al to acyclic enones to give a chiral quaternary carbon center with excellent yield and enantioselectivity under mild reaction conditions.
authors.affiliation: Department of Chemistry, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Ishikawa, Japan. kendo@se.kanazawa-u.ac.jp
authors.forename: Kohei
authors.initials: K
authors.lastname: Endo
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hamada
authors.forename: Sayuri
authors.initials: S
authors.lastname: Yakeishi
authors.forename: Takanori
authors.initials: T
authors.lastname: Shibata