title: From alcohols to indoles: a tandem Ru catalyzed hydrogen-transfer Fischer indole synthesis.
abstract: In a new version of the Fischer indole synthesis, primary and secondary alcohols have been catalytically oxidized in the presence of phenylhydrazines and protic or Lewis acids to give the corresponding indoles. The overall reaction can be accomplished in one step, and the use of alcohols instead of aldehyes or ketones as starting materials has several advantages in terms of a large selection of reagents, easy handling, and safety of the process.
authors.affiliation: Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, via Vienna 2, 07100 Sassari, Italy. anpo@uniss.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Porcheddu
authors.forename: Manuel G
authors.initials: MG
authors.lastname: Mura
authors.forename: Lidia
authors.initials: L
authors.lastname: De Luca
authors.forename: Marianna
authors.initials: M
authors.lastname: Pizzetti
authors.forename: Maurizio
authors.initials: M
authors.lastname: Taddei
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010659:Phenylhydrazines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D007211:Indoles; D010659:Phenylhydrazines; D012428:Ruthenium; D006859:Hydrogen