title: Function and evolution of ubiquitous bacterial signaling adapter phosphopeptide recognition domain FHA.
abstract: Forkhead-associated domain (FHA) is a phosphopeptide recognition domain embedded in some regulatory proteins. With similar fold type to important eukaryotic signaling molecules such as Smad2 and IRF3, the role of bacterial FHA domain is intensively pursued. Reported bacterial FHA domain roles include: regulation of glutamate and lipids production, regulation of cell shape, type III secretion, ethambutol resistance, sporulation, signal transduction, carbohydrate storage and transport, and pathogenic and symbiotic host-bacterium interactions. To provide basis for the studies of other bacterial FHA domain containing proteins, the status of bacterial FHA functionality and evolution were summarized.
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory breeding base of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, School of Life Sciences, Southwest University, Chongqing 400715, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Weiling
authors.forename: Yu
authors.initials: Y
authors.lastname: Xiaowen
authors.forename: Li
authors.initials: L
authors.lastname: Chunmei
authors.forename: Xie
authors.initials: X
authors.lastname: Jianping
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D005075:Biological Evolution; D018698:Glutamic Acid / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis; D010748:Phosphopeptides / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D008055:Lipids; D010748:Phosphopeptides; D018698:Glutamic Acid