title: Serum receptor activator of nuclear factor-κ B ligand, osteoprotegrin, and intact parathyroid hormone in hemodialysis and renal transplant patients.
abstract: Serum receptor activator of nuclear factor-κ B ligand and osteoprotegrin are mediated to vascular calcification in the general population. Our knowledge is very sparse in hemodialysis and renal transplant patients. Receptor activator of nuclear factor-κ B ligand, osteoprotegrin, intact parathyroid hormone, calcium, and phosphorus were measured in blood samples of 45 hemodialysis and 45 age-matched renal transplant patients. Osteoprotegrin (P = 0.001) and intact parathyroid hormone (P = 0.001) levels in the hemodialysis patients were higher than the renal transplant recipients. Osteoprotegrin had positive correlation with duration of dialysis and age in the hemodialysis (r = 0.88, P = 0.001 and r = 0.34, P = 0.02, respectively) and renal transplant patients (r = 0.92, P = 0.001 and r = 0.46, P = 0.001, respectively). Hemodialysis patients have higher osteoprotegrin levels than the renal transplant recipients. It may act as a protective factor for renal osteodystrophy or only as a secondary phenomenon of advanced renal failure.
authors.affiliation: Drug Applied Research Center             Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Nadereh
authors.initials: N
authors.lastname: Rashtchizadeh
authors.forename: Amir
authors.initials: A
authors.lastname: Ghorbanihaghjo
authors.forename: Hassan
authors.initials: H
authors.lastname: Argani
authors.forename: Saeed
authors.initials: S
authors.lastname: Mahmoudi Meimand
authors.forename: Javid
authors.initials: J
authors.lastname: Safa
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Vatankhahan
authors.forename: Maryam
authors.initials: M
authors.lastname: Shahidi
mesh_terms: D000328:Adult; D000367:Age Factors; D002114:Calcinosis / Q000473:pathology; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000097:blood; D053245:RANK Ligand / Q000097:blood*; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000601:surgery / Q000628:therapy; D013997:Time Factors
chemical_list: D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D053245:RANK Ligand; D010758:Phosphorus; D002118:Calcium