title: A facile synthesis for novel loperamide analogs as potential &#956; opioid receptor agonists.
abstract: A facile synthesis for novel loperamide analogs as potential &#956; opioid receptors is described. The synthetic procedure for compound 5, which contains two 4-phenyl piperidine scaffolds, was optimized, and this compound was synthesized in excellent yield. We also describe a mild and highly efficient protocol for the synthesis of compounds 6 and 7.
authors.affiliation: Department of Biochemical Engineering, Nanjing University Science & Technology, Chemical Engineering Building B302, 200 Xiaolinwei, Nanjing 210094, China. baoxiaofeng@njust.edu.cn
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Bao
authors.forename: Duliang
authors.initials: D
authors.lastname: Liu
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Jin
authors.forename: Yao
authors.initials: Y
authors.lastname: Yang
mesh_terms: D006801:Humans; D008024:Ligands; D008139:Loperamide / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009020:Morphine / Q000737:chemistry / Q000627:therapeutic use; D010880:Piperidines / Q000737:chemistry; D017450:Receptors, Opioid, mu / Q000819:agonists / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D010880:Piperidines; D017450:Receptors, Opioid, mu; D008139:Loperamide; D009020:Morphine; C048151:4-phenylpiperidine