title: Neutrophils/lymphocytes ratio in patients with cardiac syndrome X and its association with carotid intima-media thickness.
abstract: Neutrophils and lymphocytes (N/L) ratio and carotid intima-media thickness (C-IMT) value have been studied as new predictors of cardiovascular risk. We aimed to investigate N/L ratio and C-IMT value in patients with cardiac syndrome X (CSX) and compare patients with coronary artery disease (CAD) and normal participants. A total of 288 participants were enrolled in the study. The N/L ratio and C-IMT value were compared among the 3 groups. There were no statistically significant differences in N/L levels between CSX and CAD groups. The N/L ratio was found significantly increased in patients with CSX and CAD, compared to the control group. Patients with CAD and CSX had significantly higher C-IMT value compared to control participants. Significant positive correlation was found between C-IMT value and plasma level of N/L ratio. The relationship among CSX and higher N/L ratio level and C-IMT suggests that endothelial dysfunction may contribute to the etiopathogenesis of the CSX.
authors.affiliation: 1Department of Cardiology, Gulhane Medical Academy, School of Medicine, Etlik, Ankara, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Demirkol
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.forename: Murat
authors.initials: M
authors.lastname: Unlu
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Arslan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cakar
authors.forename: Ugur
authors.initials: U
authors.lastname: Kucuk
authors.forename: Turgay
authors.initials: T
authors.lastname: Celik
authors.forename: Erol
authors.initials: E
authors.lastname: Arslan
authors.forename: Turker
authors.initials: T
authors.lastname: Turker
authors.forename: Atila
authors.initials: A
authors.lastname: Iyisoy
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yokusoglu
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism / Q000473:pathology*; D011446:Prospective Studies