title: Towards metagenome-scale models for industrial applications--the case of Lactic Acid Bacteria.
abstract: We review the uses and limitations of modelling approaches that are in use in the field of Lactic Acid Bacteria (LAB). We describe recent developments in model construction and computational methods, starting from application of such models to monocultures. However, since most applications in food biotechnology involve complex nutrient environments and mixed cultures, we extend the scope to discuss developments in modelling such complex systems. With metagenomics and meta-functional genomics data becoming available, the developments in genome-scale community models are discussed. We conclude that exploratory tools are available and useful, but truly predictive mechanistic models will remain a major challenge in the field.
authors.affiliation: Systems Bioinformatics/NISB, Faculty of Earth and Life Sciences, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.
authors.forename: Filipe
authors.initials: F
authors.lastname: Branco dos Santos
authors.forename: Willem M
authors.initials: WM
authors.lastname: de Vos
authors.forename: Bas
authors.initials: B
authors.lastname: Teusink
mesh_terms: D001419:Bacteria / Q000235:genetics* / Q000378:metabolism*; D001709:Biotechnology; D017753:Ecosystem; D016680:Genome, Bacterial / Q000235:genetics*; D007700:Kinetics; D019344:Lactic Acid / Q000378:metabolism*; D007777:Lactobacillaceae / Q000235:genetics / Q000378:metabolism; D054892:Metagenome / Q000235:genetics*; D008954:Models, Biological
chemical_list: D019344:Lactic Acid