title: Brain white matter hyperintensities in migraine: clinical and radiological correlates.
abstract: OBJECTIVE
  Migraine is a recognised cause of brain white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI). However radiological characteristics of those in migraine are not well defined. We sought to study the radiological characteristics and factors associated with WMH in migraine.
  
  
  METHODS
  Migraine patients who were investigated with MRI of the brain in the outpatient clinic were studied retrospectively. Two groups were delineated based on the presence or absence of WMH in MRI scans. The clinical and demographic characteristics between the two groups were compared to delineate the associations of WMH.
  
  
  RESULTS
  Forty four patients were studied, out of which 19 demonstrated WMH on MRI. Frontal lobe was involved in all subjects with WMH. Infratentorial hyperintensities were not seen in any. Subcortical and deep white matter was the commonest distribution while callosal and subcallosal lesions were very rare. Family history of migraine, increasing age, and increasing headache frequency emerged as significant associations of WMH in multivariable analysis.
  
  
  CONCLUSIONS
  There are characteristic radiological features and clinical associations of WMH in migraine.
authors.affiliation: Department of Neuroscience, Monash Medical Centre & Monash University, Clayton, VIC 3168, Australia. udaya.seneviratne@monash.edu
authors.forename: Udaya
authors.initials: U
authors.lastname: Seneviratne
authors.forename: Winston
authors.initials: W
authors.lastname: Chong
authors.forename: P H
authors.initials: PH
authors.lastname: Billimoria
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis / Q000473:pathology*; D012189:Retrospective Studies; D055815:Young Adult