title: Severe pulmonary hypertension associated with emphysema: a new phenotype?
abstract: Mild to moderate precapillary pulmonary hypertension (PH) is a common complication of COPD and has typically been related to severe airflow limitation associated with chronic hypoxemia. Previous studies focusing specifically on patients with emphysema found that worsening PH was associated with progression of airflow obstruction. In the present report, we describe a new phenotype of COPD with severe precapillary PH in patients presenting with progressive dyspnea, normal spirometry, severely reduced diffusion capacity of the lung for carbon monoxide, and high-resolution CT scans of the chest showing diffuse centrilobular emphysema.
authors.affiliation: Pulmonary Division, Carmel Medical Center, Faculty of Medicine, The Technion, Institute of Technology, Haifa, Israel. Electronic address: adir-sh@zahav.net.il.
authors.forename: Yochai
authors.initials: Y
authors.lastname: Adir
authors.affiliation: Radiology Division, Carmel Medical Center, Faculty of Medicine, The Technion, Institute of Technology, Haifa, Israel.
authors.forename: Robert
authors.initials: R
authors.lastname: Shachner
authors.affiliation: Cardiology Division, Carmel Medical Center, Faculty of Medicine, The Technion, Institute of Technology, Haifa, Israel.
authors.forename: Offer
authors.initials: O
authors.lastname: Amir
authors.affiliation: Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, Le Plessis-Robinson, France; Assistance Publique Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, Le Plessis-Robinson, France; Institut National de la Santé et de la Recherche Médicale (Inserm) U999, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Humbert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004646:Emphysema / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D010641:Phenotype; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed