title: Thermolides, potent nematocidal PKS-NRPS hybrid metabolites from thermophilic fungus Talaromyces thermophilus.
abstract: Macrocyclic PKS-NRPS hybrid metabolites represent a unique family of natural products mainly from bacteria with broad and outstanding biological activities. However, their distribution in fungi has rarely been reported, and little has been reported regarding their nematocidal activity. Here we describe an unprecedented class of PKS-NRPS hybrid metabolites possessing a 13-membered lactam-bearing macrolactone, thermolides A-F (1-6) from a thermophilic fungus Talaromyces thermophilus. We showed that 1 and 2 displayed potent inhibitory activity against three notorious nematodes with LC(50) values of 0.5-1 μg/mL, as active as commercial avermectins. This work provided a new class of promising lead compounds for nematocide discovery.
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming 650091, PR China.
authors.forename: Ji-Peng
authors.initials: JP
authors.lastname: Guo
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Zhu
authors.forename: Chuan-Ping
authors.initials: CP
authors.lastname: Zhang
authors.forename: Yan-Sheng
authors.initials: YS
authors.lastname: Chu
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Wang
authors.forename: Jun-Xian
authors.initials: JX
authors.lastname: Zhang
authors.forename: De-Kai
authors.initials: DK
authors.lastname: Wu
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Niu
mesh_terms: D000969:Antinematodal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D048630:Polyketide Synthases / Q000378:metabolism*; D032901:Talaromyces / Q000378:metabolism*
chemical_list: D000969:Antinematodal Agents; D048630:Polyketide Synthases