title: Clinical significance of Mena and Her-2 expression in breast cancer.
abstract: OBJECTIVE
  The aim of this study was to determine the expression patterns of Mena and Her-2 in breast cancer tissues and to explore their clinical significance and correlation with clinicopathological parameters.
  
  
  METHODS
  The expression of Mena and Her-2 was detected in 40 breast cancer tissues and 14 normal breast tissues by immunohistochemistry, and the relationship of Mena and Her-2 expression with clinicopathological parameters was analyzed.
  
  
  RESULTS
  Both Mena (70%) and Her-2 (40%) were more commonly expressed in breast cancer than in normal breast tissue (7.1%, 0%, respectively; p < 0.05); further, Mena and Her-2 expression in breast cancer were positively correlated (r = 0.530, p < 0.05). In comparing expression with clinicopathological parameters of tumor samples, Mena and Her-2 were both associated with axillary lymph node metastasis and TNM stage (p < 0.05), but not with patient age or pathological type.
  
  
  CONCLUSIONS
  Mena and Her-2 are related to the malignancy degree and metastasis of breast cancer, and thus may play a coordinating role in the occurrence and progression of breast cancer.
authors.affiliation: School of Medicine, Anhui University of Science & Technology, Huainan, Anhui Province, PR China. djwdxswy@126.com
authors.forename: J W
authors.initials: JW
authors.lastname: Du
authors.forename: K Y
authors.initials: KY
authors.lastname: Xu
authors.forename: L Y
authors.initials: LY
authors.lastname: Fang
authors.forename: X L
authors.initials: XL
authors.lastname: Qi
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000737:chemistry*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008840:Microfilament Proteins / Q000032:analysis*; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*
chemical_list: D008840:Microfilament Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; C511939:Enah protein, human; C508053:ERBB2 protein, human