title: Circulating soluble receptor for advanced glycation end products is inversely correlated to oxidized low-density lipoproteins in asymptomatic subjects.
abstract: OBJECTIVE
  There is growing evidence that circulating soluble receptor for advanced glycation end products (sRAGE) exerts antiatherogenic effects as a decoy receptor that abolishes RAGE signalling. A previous study reported that oxidized low-density lipoprotein (oxLDL) can be one of  the RAGE ligands. The present cross-sectional study investigated the clinical association between sRAGE and oxLDL in humans.
  
  
  METHODS
  Serum levels of the conventional atherosclerotic risk factors, sRAGE and malondialdehyde-modified low-density lipoprotein (MDA-LDL) were analysed in asymptomatic  subjects; MDA-LDL was measured as a biomarker of oxLDL.
  
  
  RESULTS
  Mean serum levels of sRAGE and MDA-LDL were 1101 ng/l and 57.6 IU/l, respectively, in 33 subjects of mean age 65 years. Simple linear regression analysis showed a significant inverse correlation between sRAGE and  MDA-LDL. Stepwise multiple linear regression analysis confirmed MDA-LDL to be independently, significantly and inversely correlated with sRAGE.
  
  
  CONCLUSIONS
  An independent, significant and inverse correlation was shown to exist between circulating levels of sRAGE and oxLDL (MDA-LDL),  which suggests that part of the antiatherosclerotic effects of sRAGE may be related to oxLDL quenching.
authors.affiliation: Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan. kazukotani@jichi.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Kotani
authors.forename: R
authors.initials: R
authors.lastname: Caccavello
authors.forename: N
authors.initials: N
authors.lastname: Taniguchi
authors.forename: A
authors.initials: A
authors.lastname: Gugliucci
mesh_terms: D000368:Aged; D058070:Asymptomatic Diseases; D050197:Atherosclerosis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde