title: Controlling the function of DNA nanostructures with specific trigger sequences.
abstract: We report a hybridization-based switching mechanism with single-base specificity that can be readily integrated with functional DNA nanostructures. As an exemplar, we have developed a switchable DNAzyme (SDZ) that only becomes activated in the presence of a perfectly matched trigger sequence and operates effectively at room temperature.
authors.affiliation: Department of Mechanical Engineering, University of California, Santa Barbara, CA 93106, USA.
authors.forename: Stijn
authors.initials: S
authors.lastname: Deborggraeve
authors.forename: Jian Yuan
authors.initials: JY
authors.lastname: Dai
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiao
authors.forename: Hyongsok Tom
authors.initials: HT
authors.lastname: Soh
mesh_terms: D020137:Base Pair Mismatch; D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D021881:DNA, Catalytic / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D061848:Optical Imaging
chemical_list: D021881:DNA, Catalytic; D004247:DNA