title: Personality functioning and the cortical midline structures--an exploratory FMRI study.
abstract: OBJECTIVE
  Recent neuroscience studies explored the neuronal mechanisms underlying our sense of self. Thereby the cortical midline structures and their anterior and posterior regions have been shown to be central. What remains unclear though is how both, self and cortical midline structures, are related to the identity of the self which is of central importance in especially personality disorders.
  
  
  METHODS
  Conducting an exploratory study with a dimensional approach, we here compared subjects with high and low level of personality functioning and identity integration as measured in a standardized way in fMRI during both, emotion- and reward-related tasks.
  
  
  RESULTS
  Low levels of personality functioning and identity integration were predicted by significantly decreased degrees of deactivation in the anterior and posterior cortical midline structures.
  
  
  CONCLUSIONS
  Though exploratory our results show for the first time direct relationship between cortical midline structures and personality functioning in terms of identity integration. This does not only contribute to our understanding of the neuronal mechanism underlying self and identity but carries also major implications for the treatment of patients with personality disorders.
authors.affiliation: Department of Psychoanalysis and Psychotherapy, Medical University of Vienna, Vienna, Austria. stephan.doering@meduniwien.ac.at
authors.forename: Stephan
authors.initials: S
authors.lastname: Doering
authors.forename: Björn
authors.initials: B
authors.lastname: Enzi
authors.forename: Cornelius
authors.initials: C
authors.lastname: Faber
authors.forename: Jens
authors.initials: J
authors.lastname: Hinrichs
authors.forename: Judith
authors.initials: J
authors.lastname: Bahmer
authors.forename: Georg
authors.initials: G
authors.lastname: Northoff
mesh_terms: D000328:Adult; D001883:Borderline Personality Disorder / Q000175:diagnosis; D001921:Brain / Q000502:physiology; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010551:Personality / Q000502:physiology*; D055815:Young Adult