title: Chemotherapy for initial induction failures in childhood acute lymphoblastic leukemia: a Children's Oncology Group Study (POG 8764).
abstract: Children with acute lymphocytic leukemia who fail to enter remission have a poor prognosis. In a previous study, 9 of 14 children with induction failure entered remission after teniposide (VM26) plus cytosine arabinoside (Ara-C). We attempted to confirm these results. Twenty children received teniposide (200 mg/m/day IV) for 3 days and cytosine arabinoside (100 mg/m/day continuous IV infusion) for 7 days. There were 3 complete and 3 partial responses. Two additional patients achieved a complete response after a second, shorter course of the same agents. Although VM26 plus Ara-C is an active combination for treatment of acute lymphocytic leukemia induction failure, it does not appear as effective as in the initial report. Better treatments for this problem are needed.
authors.affiliation: Nemours Children's Clinic, Jacksonville, FL, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Joyce
authors.forename: Brad H
authors.initials: BH
authors.lastname: Pollock
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Devidas
authors.forename: George R
authors.initials: GR
authors.lastname: Buchanan
authors.forename: Bruce
authors.initials: B
authors.lastname: Camitta
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003561:Cytarabine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012074:Remission Induction; D013713:Teniposide / Q000008:administration & dosage; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003561:Cytarabine; D013713:Teniposide; D006854:Hydrocortisone; D008727:Methotrexate