title: A study of the link between bone turnover markers and bone mineral density with inflammation and body mass in postmenopausal women with active rheumatoid arthritis.
abstract: In this study, the levels of bone turnover markers (BTMs) and bone mineral density (BMD) were studied in relation to body mass and several inflammatory markers, in postmenopausal patients with rheumatoid arthritis (RA). Fifty-nine postmenopausal women with active RA (lean, overweight, obese) were studied. The femoral BMD and serum levels of BTMs: osteocalcin (OC) and collagen type I cross-linked C-telopeptide fragments (CTX), and osteopontin (OPN), resistin, high sensitivity C-reactive protein, interleukin-6, tumor necrosis factor (TNF)-α in these patients were measured. It has been noticed that obese women had significantly higher total femoral BMD and total T-score compared to the lean subjects (p ≤ 0.01). The significant associations of BMD measures and CTX levels with body mass parameters (p ≤ 0.01 and p < 0.05, respectively) were found. Values of neck BMD adjusted for BMI were inversely associated with concentrations of TNF-α (p < 0.05). Osteocalcin levels inversely correlated with resistin (p ≤ 0.01) and CTX levels positively correlated with OPN (p ≤ 0.01). There were found no associations between BTMs and BMD with other inflammatory indices. Inverse correlations between OPN levels and body mass (p < 0.05), waist circumference (p < 0.05), and duration of postmenopausal period (p ≤ 0.01) were observed. Findings of the present study suggest that body mass and inflammatory markers, most of all OPN, resistin and TNF-α, play an important role in bone metabolism in postmenopausal women with active RA.
authors.affiliation: Department of Physiotherapy, University School of Physical Education, Królowej Jadwigi 27/39, 61-871, Poznan, Poland. a.straburzynskalupa@gmail.com
authors.forename: Anna
authors.initials: A
authors.lastname: Straburzyńska-Lupa
authors.forename: Alicja
authors.initials: A
authors.lastname: Nowak
authors.forename: Wojciech
authors.initials: W
authors.lastname: Romanowski
authors.forename: Paweł
authors.initials: P
authors.lastname: Korman
authors.forename: Łucja
authors.initials: Ł
authors.lastname: Pilaczyńska-Szcześniak
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood*; D001835:Body Weight; D015519:Bone Density; D016723:Bone Remodeling; D005260:Female; D005269:Femur / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D017698:Postmenopause / Q000097:blood*; D052243:Resistin / Q000097:blood
chemical_list: D015415:Biomarkers; D052243:Resistin; D015675:Osteocalcin