title: [Sweet's syndrome: retrospective case series of 47 patients].
abstract: OBJECTIVE
  Also called acute febrile neutrophilic dermatosis, Sweet's syndrome is an inflammatory disorder with a prominent cutaneous expression. It is characterized by a variety of manifestations, clinical and histological findings. The objective of this study was to describe their clinical, pathological and therapeutic characteristics.
  
  
  METHODS
  We report on a series of 47 patients who presented a Sweet's syndrome, collected in our institution in Tunis between 1997 and 2011.
  
  
  RESULTS
  The patient population consisted of 11 men and 36 women. The mean age was 47 years with extreme ranging from 28 to 74 years. An associated disorder was observed in ten patients: inflammatory disease (three cases), inflammatory bowel disease (two cases), tuberculosis (three cases) and diabetes (three cases). One case of pregnancy was observed. Cutaneous lesions consisted of erythematous plaques or nodules. Lesions were located mainly on the upper or lower extremities. All biopsy specimens demonstrated a dermal infiltrate composed predominantly of neutrophils. Fibrinoid necrosis and intramural inflammation were observed in eight cases.
  
  
  CONCLUSIONS
  The skin disorder can precede, follow, or appear concurrent with the diagnosis of an associated disease which requires careful surveillance.
authors.affiliation: Service d'anatomie et de cytologie pathologiques, hôpital La Rabta, Tunis, Tunisie.
authors.forename: I
authors.initials: I
authors.lastname: Chelly
authors.forename: A
authors.initials: A
authors.lastname: Zehani
authors.forename: A
authors.initials: A
authors.lastname: Mbazaa
authors.forename: H
authors.initials: H
authors.lastname: Azouz
authors.forename: H
authors.initials: H
authors.lastname: Nfoussi
authors.forename: N
authors.initials: N
authors.lastname: Kchir
authors.forename: S
authors.initials: S
authors.lastname: Haouet
authors.forename: M
authors.initials: M
authors.lastname: Zitouna
mesh_terms: D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000150:complications; D003424:Crohn Disease / Q000150:complications; D048909:Diabetes Complications; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006074:Gout Suppressants / Q000627:therapeutic use; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications; D012189:Retrospective Studies; D016463:Sweet Syndrome / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D014376:Tuberculosis / Q000150:complications
chemical_list: D000890:Anti-Infective Agents; D005938:Glucocorticoids; D006074:Gout Suppressants; D006633:Histamine Antagonists