title: Effect of single-dose extended-release oral azithromycin on anticoagulation status in warfarinized patients.
abstract: OBJECTIVE
  The aim of this study was to investigate the possible influence of single-dose 2.0-g azithromycin (AZ-ER) on anticoagulation in patients taking warfarin.
  
  
  METHODS
  Eighteen consecutive patients receiving long-term stable warfarin therapy were enrolled in this study. AZ-ER was administered 1 hour prior to tooth extraction. The international normalized ratio (INR) value was measured prior to AZ-ER administration as well as during, 1 day after, and 7 days after the tooth extraction. Additionally, the azithromycin concentration in the extraction wound as well as in the peripheral venous blood was assessed.
  
  
  RESULTS
  The changes in INR throughout the study period were not statistically significant (2-factor analysis of variance, NS). The azithromycin concentration in extraction wounds was higher than that in peripheral veins.
  
  
  CONCLUSIONS
  The results of this study suggest that prophylactic administration of AZ-ER to patients receiving daily warfarin therapy with a stable coagulation status has no relevant effect on the anticoagulant effect of warfarin.
authors.affiliation: Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kusafuka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kurita
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sakurai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Katsuyama
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ohmori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000925:Anticoagulants / Q000627:therapeutic use*; D017963:Azithromycin / Q000008:administration & dosage*; D001777:Blood Coagulation / Q000187:drug effects*; D003692:Delayed-Action Preparations / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D014081:Tooth Extraction; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D003692:Delayed-Action Preparations; D014859:Warfarin; D017963:Azithromycin