title: Mullerian carcinosarcoma arising in the cecum associated with florid vascular proliferation/glomeruloid microvascular proliferation.
abstract: Angiogenesis is required for tumor growth, and the degree of new vessel formation correlates with adverse prognosis in many types of malignancies. It has now been appreciated that tumor-associated vasculature is heterogenous and sometimes includes a complex vasoformative process that has been termed florid vascular proliferation or glomeruloid microvascular proliferation. These vascular lesions are most characteristic of high-grade gliomas and neuroendocrine tumors but are being increasingly recognized in other types of neoplasias as well. Herein we report a case of carcinosarcoma arising within the cecal wall of a 62-yr-old patient that exhibited florid vascular proliferation, particularly at the time of peritoneal recurrence. Recognition of these tumor-associated vasoformative lesions may be important in view of their adverse prognostic association and may become therapeutically relevant considering the current developments in angiogenesis inhibitors.
authors.affiliation: Department of Histopathology, University of Western Australia, Perth, Western Australia, Australia. colin.stewart@health.wa.gov.au
authors.forename: Colin J R
authors.initials: CJ
authors.lastname: Stewart
authors.forename: Disna
authors.initials: D
authors.lastname: Abeysuriya
authors.forename: Priyanthi
authors.initials: P
authors.lastname: Kumarasinghe
authors.forename: Stuart
authors.initials: S
authors.lastname: Salfinger
authors.forename: Jason
authors.initials: J
authors.lastname: Tan
mesh_terms: D002296:Carcinosarcoma / Q000473:pathology*; D002432:Cecum / Q000473:pathology*; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology*; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology