title: The effect of coenzyme Q10 in statin myopathy.
abstract: OBJECTIVE
  Statins significantly reduce CV morbidity and mortality. Unfortunately, one of the side effects of statins is myopathy, for which statins cannot be administered in sufficient doses or administered at all. The aim of this study was to demonstrate the effect of coenzyme Q10 in patients with statin myopathy.
  
  
  METHODS
  Twenty eight patients aged 60.6±10.7 years were monitored (18 women and 10 men) and treated with different types and doses of statin. Muscle weakness and pain was monitored using a scale of one to ten, on which patients expressed the degree of their inconvenience. Examination of muscle problems was performed prior to administration of CQ10 and after 3 and 6 months of dosing. Statistical analysis was performed using Friedman test, Annova and Students t-test.
  
  
  RESULTS
  Pain decreased on average by 53.8% (p<0.0001), muscle weakness by 44.4% (p<0.0001). The CQ10 levels were increased by more than 194% (from 0,903 μg/ml to 2.66 μg/ml; p<0.0001).
  
  
  CONCLUSIONS
  After a six-month administration of coenzyme Q10, muscle pain and sensitivity statistically significantly decreased.
authors.affiliation: 3rd Department of Internal Medicine, Charles University and General Teaching Hospital, Prague, Czech Republic. lukas.zlatohlavek@lf1.cuni.cz
authors.forename: Lukas
authors.initials: L
authors.lastname: Zlatohlavek
authors.forename: Michal
authors.initials: M
authors.lastname: Vrablik
authors.forename: Barbora
authors.initials: B
authors.lastname: Grauova
authors.forename: Eva
authors.initials: E
authors.lastname: Motykova
authors.forename: Richard
authors.initials: R
authors.lastname: Ceska
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000139:chemically induced* / Q000188:drug therapy*; D059352:Musculoskeletal Pain / Q000139:chemically induced* / Q000188:drug therapy*; D017060:Patient Satisfaction; D016896:Treatment Outcome; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10