title: Synthesis and cytotoxicity of (+/-)-7,9-dideoxy-pancratistatin analogues.
abstract: Access to some 7,9-dideoxy analogues of pancratistatin was achieved by combining our previously reported nitroenal/dioxanone annulation (to form ring C) with a hetero-Diels-Alder/aromatization path to build the dihydroisoquinolinone subunit (rings A and B); testing of their antiproliferative activity afforded some clues about the role of aromatic substituents in pancratistatin's pharmacophore.
authors.affiliation: Department of Organic Chemistry, University of Santiago de Compostela, Campus Vida, 15782 Santiago de Compostela, Spain. olaia.nieto@fu-berlin.de
authors.forename: Olaia
authors.initials: O
authors.lastname: Nieto-García
authors.forename: Ricardo
authors.initials: R
authors.lastname: Alonso
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D061986:MCF-7 Cells; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: C476205:2,7-dideoxypancratistatin; D000970:Antineoplastic Agents; D007546:Isoquinolines