title: Five new diterpenoids from an Okinawan soft coral, Cespitularia sp.
abstract: Five new diterpenoids 1-5 were isolated from an Okinawan soft coral, Cespitularia sp., together with the known diterpenoid, alcyonolide (6). New diterpenoid structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Alcyonolide (6) was cytotoxic against HCT 116 cells (IC₅₀ 5.85 μM), while these new diterpenoids 1-5 were much less active (IC₅₀ 28.2-91.4 μM).
authors.affiliation: Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho, Okinawa 903-2013, Japan.
authors.forename: Prodip K
authors.initials: PK
authors.lastname: Roy
authors.forename: Wilmar
authors.initials: W
authors.lastname: Maarisit
authors.forename: Michael C
authors.initials: MC
authors.lastname: Roy
authors.forename: Junsei
authors.initials: J
authors.lastname: Taira
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Ueda
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045325:HCT116 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007564:Japan; D013057:Spectrum Analysis
chemical_list: D004224:Diterpenes