title: A brain abscess of probable odontogenic origin in a child with cyanotic heart disease.
abstract: The purpose of the present report was to present a rare case of a brain abscess in a child with heterotaxy syndrome, severe cardiac anomalies, and extensive dental caries. The pathogen was Streptococcus intermedius isolated from the cerebrospinal fluid. The source of the pathogen was  probably an infection of a primary molar with a dentoalveolar abscess involving the bud of the permanent successor. After a long course of antibiotic regimens followed by a craniotomy with abscess drainage, a shunt, and comprehensive dental treatment, the patient was discharged from the hospital  without any neurological sequel. At home, she completed an additional 3 months of oral antibiotics. This is the only known documented case of a toddler with a brain abscess of probable odontogenic origin without previous dental intervention. It emphasizes the importance of collaboration between  cardiologists and pediatric dentists, especially in referring children with congenital heart defects for early dental checkups.
authors.affiliation: Department of Pediatric Dentistry, Hebrew University-Hadassah Medical Center, Jerusalem, Israel. motim@md.huji.ac.il
authors.forename: Moti
authors.initials: M
authors.lastname: Moskovitz
authors.forename: Ravit
authors.initials: R
authors.lastname: Birenboim
authors.forename: Hadas
authors.initials: H
authors.lastname: Katz-Sagi
authors.forename: Zeev
authors.initials: Z
authors.lastname: Perles
authors.forename: Diana
authors.initials: D
authors.lastname: Averbuch
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001922:Brain Abscess / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology* / Q000601:surgery; D002443:Ceftriaxone / Q000627:therapeutic use; D002557:Cerebrospinal Fluid Shunts; D002675:Child, Preschool; D003399:Craniotomy; D003731:Dental Caries / Q000150:complications; D003914:Dextrocardia / Q000150:complications; D005260:Female; D005491:Focal Infection, Dental / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D006330:Heart Defects, Congenital / Q000150:complications*; D059446:Heterotaxy Syndrome / Q000150:complications; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use; D008963:Molar / Q000473:pathology; D010482:Periapical Abscess / Q000150:complications*; D013290:Streptococcal Infections / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D034367:Streptococcus intermedius / Q000302:isolation & purification; D014083:Tooth Germ / Q000473:pathology; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D014640:Vancomycin; D002443:Ceftriaxone