title: Extracellular matrix heterogeneity regulates three-dimensional morphologies of breast adenocarcinoma cell invasion.
abstract: Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs.
authors.affiliation: School of Mechanical Engineering, Korea University, Anam-Dong, Seongbuk-Gu, Seoul 136-713, Korea.
authors.forename: Yoojin
authors.initials: Y
authors.lastname: Shin
authors.forename: Hyunju
authors.initials: H
authors.lastname: Kim
authors.forename: Sewoon
authors.initials: S
authors.lastname: Han
authors.forename: Jihee
authors.initials: J
authors.lastname: Won
authors.forename: Hyo Eun
authors.initials: HE
authors.lastname: Jeong
authors.forename: Eun-Sook
authors.initials: ES
authors.lastname: Lee
authors.forename: Roger D
authors.initials: RD
authors.lastname: Kamm
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Seok
authors.initials: S
authors.lastname: Chung
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000503:physiopathology*; D001943:Breast Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D045744:Cell Line, Tumor; D002469:Cell Separation / Q000295:instrumentation; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005109:Extracellular Matrix / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000503:physiopathology; D014463:Ultrasonography