title: Meropenem as predictive risk factor for isolation of multidrug-resistant Pseudomonas aeruginosa.
abstract: The objective of this study was to explore independent risk factors for the isolation of multidrug-resistant (MDR) Pseudomonas aeruginosa in a Japanese university hospital between January 1997 and December 2010. MDR P. aeruginosa was defined when the organism was resistant or intermediately susceptible to all five antimicrobials tested. In all, 159 patients with MDR P. aeruginosa were identified over the 14-year period. Multivariate logistic regression analysis revealed that prolonged hospital stay, prior exposure to meropenem and fluoroquinolones, and patients suffering from diabetes mellitus or receiving surgery were predictive risk factors for the isolation of MDR P. aeruginosa.
authors.affiliation: Department of Clinical Laboratory, Juntendo University Hospital, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Miyake
authors.forename: S
authors.initials: S
authors.lastname: Misawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kuno
authors.forename: T
authors.initials: T
authors.lastname: Horii
authors.forename: S
authors.initials: S
authors.lastname: Kondo
authors.forename: Y
authors.initials: Y
authors.lastname: Tabe
authors.forename: A
authors.initials: A
authors.lastname: Ohsaka
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D048909:Diabetes Complications; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones / Q000627:therapeutic use; D006785:Hospitals, University; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007902:Length of Stay; D000077731:Meropenem; D011183:Postoperative Complications; D011552:Pseudomonas Infections / Q000453:epidemiology* / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification*; D012307:Risk Factors; D013845:Thienamycins / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D013845:Thienamycins; D000077731:Meropenem