title: Functionalized magnetonanoparticles in visualization of intracranial tumors on MRI.
abstract: OBJECTIVE
  The development of nonradioactive and targeted magnetonanoparticles (MNP) capable of crossing the blood-brain barrier (BBB) and of concentrating in and enhancing the contrast of intracranial tumors on magnetic resonance imaging (MRI).
  
  
  METHODS
  Nonradioactive 2-deoxy-D-glucose (2DG) was covalently attached to magnetonanoparticles composed of iron oxide and dextran and prepared for intravenous (tail) injection in the naïve rats and mouse models of glioma. MR images were acquired at 3 and 7 T.
  
  
  RESULTS
  2DG-MNP increased tumor visibility and improved delineation of tumor margins. Histopathology confirmed that 2DG-MNP crossed the BBB and accumulated within brain parenchyma.
  
  
  CONCLUSIONS
  Nonradioactive 2DG-MNP can cross an intact BBB on and improve visualization of tumor and tumor margins on MRI.
authors.affiliation: Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen school of Medicine, University of California, Los Angeles, CA, USA, Akhtarim@ucla.edu
authors.forename: Massoud
authors.initials: M
authors.lastname: Akhtari
authors.forename: Whitney
authors.initials: W
authors.lastname: Pope
authors.forename: Gary
authors.initials: G
authors.lastname: Mathern
authors.forename: Rex
authors.initials: R
authors.lastname: Moats
authors.forename: Andrew
authors.initials: A
authors.lastname: Frew
authors.forename: Mark
authors.initials: M
authors.lastname: Mandelkern
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000009:adverse effects; D003847:Deoxyglucose; D005910:Glioma / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000648:ultrastructure; D051379:Mice; D008819:Mice, Nude; D051381:Rats; D023041:Xenograft Model Antitumor Assays
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles; D003847:Deoxyglucose