title: Secondary metabolites from the roots of Beilschmiedia tsangii and their anti-inflammatory activities.
abstract: Four new endiandric acid analogues, tsangibeilin C (1), tsangibeilin D (2), tricyclotsangibeilin (3) and endiandric acid M (4), one new lignan, beilschminol B (5) and two new sesquiterpenes, (+)-5-hydroxybarbatenal (6) and (4R,5R)-4,5-dihydroxycaryophyll-8(13)-ene (7), together with four known compounds (8-11), were isolated from the roots of Beilschmiedia tsangii (Lauraceae). The structures of 1-7 were determined by spectroscopic techniques. Among the isolates, endiandric acid M (4) exhibited moderate iNOS inhibitory activity, with an IC(50) value of 31.70 μM.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. u96830006@kmu.edu.tw.
authors.forename: Yun-Ting
authors.initials: YT
authors.lastname: Huang
authors.forename: Hsun-Shuo
authors.initials: HS
authors.lastname: Chang
authors.forename: Guei-Jane
authors.initials: GJ
authors.lastname: Wang
authors.forename: Chu-Hung
authors.initials: CH
authors.lastname: Lin
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D019770:Lauraceae / Q000737:chemistry* / Q000378:metabolism; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors; D018517:Plant Roots / Q000737:chemistry* / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D002264:Carboxylic Acids; D017705:Lignans; D012717:Sesquiterpenes; C534861:endiandric acid; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II