title: Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides.
abstract: Quorum-sensing (QS) peptides are biologically attractive molecules, with a wide diversity of structures and prone to modifications altering or presenting new functionalities. Therefore, the Quorumpeps database (http://quorumpeps.ugent.be) is developed to give a structured overview of the QS oligopeptides, describing their microbial origin (species), functionality (method, result and receptor), peptide links and chemical characteristics (3D-structure-derived physicochemical properties). The chemical diversity observed within this group of QS signalling molecules can be used to develop new synthetic bio-active compounds.
authors.affiliation: Drug Quality and Registration (DruQuaR) group, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent Hospital University, Ghent B-9000, Belgium.
authors.forename: Evelien
authors.initials: E
authors.lastname: Wynendaele
authors.forename: Antoon
authors.initials: A
authors.lastname: Bronselaer
authors.forename: Joachim
authors.initials: J
authors.lastname: Nielandt
authors.forename: Matthias
authors.initials: M
authors.lastname: D'Hondt
authors.forename: Sofie
authors.initials: S
authors.lastname: Stalmans
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bracke
authors.forename: Frederick
authors.initials: F
authors.lastname: Verbeke
authors.forename: Christophe
authors.initials: C
authors.lastname: Van De Wiele
authors.forename: Guy
authors.initials: G
authors.lastname: De Tré
authors.forename: Bart
authors.initials: B
authors.lastname: De Spiegeleer
mesh_terms: D062126:Databases, Chemical; D020407:Internet; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D053038:Quorum Sensing
chemical_list: D010455:Peptides