title: General pharmacological properties of TJ-9 extract.
abstract: The general pharmacological properties of TJ-9 extract were investigated in various experimental animals. TJ-9 extract at 0.3, 1.0 and 3.0g/kg showed no effect on spontaneous locomotor activity, hexobarbital-induced sleeping time, electroshock-, strychnine-, and pentylenetetrazol-induced convulsions, frequency of acetic acid-induced writhing, body temperature, and skeletal muscle coordination in mice. In anesthetized dogs, TJ-9 extract at 0.3, 1.0 and 3.0 g/kg, had no effect on the frequency of respiration, blood pressure, heart rate, and ECG. TJ-9 extract at 10(-4), 10(-5) and 10(-6)g/ml also had no effect on acetylcholine or barium chloride-induced contraction of guinea pig ileum. TJ-9 extract at 10(-4)g/ml, however, increased histamine-induced contractions, and spontaneous motility of the guinea pig ileum. TJ-9 extract at 0.3, 1.0 and 3.0 g/kg had no effect on blood coagulation and platelet aggregation in rats. TJ-9 extract at the lowest dose of 0.3 g/kg inhibited the gastric juice secretion, gastric pH, and gastric acid output, and at 1.0 g/kg inhibited the gastric acidity and bile secretion in rats. TJ-9 extract at 0.3, 1.0, and 3.0 g/kg, however, had no effect on the intestinal transport of charcoal meal in rats. TJ-9 extract at 3.0 g/kg produced a decrease of urine volume, but never decreased the urine electrolytes, Na(+), K(+), and CI concentration. These results suggest that TJ-9 extract exerts anti-ulcer properties by inhibiting the gastric secretion and gastric acid output, but it showed no notable pharmacological effects on the central nervous system, autonomic nervous system or smooth muscle function, respiratory and cardiovascular system, and blood coagulation and fibrinolysis function.
authors.affiliation: Central Research Laboratories, Tsumura & Co., Japan.
authors.forename: S
authors.initials: S
authors.lastname: Amagaya
authors.forename: A
authors.initials: A
authors.lastname: Ishige
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: S
authors.initials: S
authors.lastname: Shindo
authors.forename: S
authors.initials: S
authors.lastname: Maemura
authors.forename: M
authors.initials: M
authors.lastname: Kubo
authors.forename: Y
authors.initials: Y
authors.lastname: Komatsu
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Terasawa