title: Incidence and characteristics of pseudoprecocious puberty because of severe primary hypothyroidism.
abstract: Severe primary hypothyroidism is a presumed rare cause of pseudoprecocious puberty (PsPP). Here, we report a 24% incidence of PsPP among 33 children with profound hypothyroidism. Those with PsPP were older and trended toward a higher thyroid stimulating hormone. Increased awareness of PsPP can hasten diagnosis and appropriate treatment.
authors.affiliation: Section of Endocrinology/Diabetology, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA. scabrera@mcw.edu
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Cabrera
authors.forename: Linda A
authors.initials: LA
authors.lastname: DiMeglio
authors.forename: Erica A
authors.initials: EA
authors.lastname: Eugster
mesh_terms: D000293:Adolescent; D002648:Child; D003409:Congenital Hypothyroidism / Q000150:complications*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin