title: A shared biosynthetic pathway for botcinins and botrylactones revealed through gene deletions.
abstract: Isotopic labelling experiments and the study of mutants with disrupted genes encoding botcinic acid have revealed a common link in the biosynthesis of the polyketide toxins excreted by Botrytis cinerea: botcinins and botrylactones. Furthermore, the results reported here shed light on the origin of the starter unit, thereby solving a long-standing mystery in the biosynthesis of botcinins.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Cádiz, Spain.
authors.forename: Michelli
authors.initials: M
authors.lastname: Massaroli
authors.forename: Javier
authors.initials: J
authors.lastname: Moraga
authors.forename: Keyller
authors.initials: K
authors.lastname: Bastos Borges
authors.forename: Jacinto
authors.initials: J
authors.lastname: Ramírez-Fernández
authors.forename: Muriel
authors.initials: M
authors.lastname: Viaud
authors.forename: Isidro
authors.initials: I
authors.lastname: González Collado
authors.forename: Rosa
authors.initials: R
authors.lastname: Durán-Patrón
authors.forename: Rosario
authors.initials: R
authors.lastname: Hernández-Galán
mesh_terms: D020171:Botrytis / Q000235:genetics* / Q000378:metabolism*; D017353:Gene Deletion; D007783:Lactones / Q000737:chemistry / Q000378:metabolism*; D011753:Pyrones / Q000378:metabolism*
chemical_list: D007783:Lactones; D011753:Pyrones