title: The survey of diastolic function changes in end-stage renal disease patients before and 3 and 6 months after kidney transplantation.
abstract: BACKGROUND
  Left ventricular diastolic dysfunction, which is prevalent in end-stage renal disease, predicts morbidity and mortality among affected patients. The aim of this study was to evaluate diastolic function changes in end-stage renal disease patients before as well as 3 and 6 months after kidney transplantation.
  
  
  METHODS
  This longitudinal study from November 2008 to November 2009, enrolled 27 consecutive kidney transplant patients. Systolic and diastolic blood pressures and echocardiograghic parameters such as ejection fraction, left ventricular mass, and diastolic functions were measured before, as well as 3 and 6 months after transplantation. Data were analyzed by repeated-measure analysis of variance and Friedman tests using SPSS version 18.
  
  
  RESULTS
  The mean patients age was 39.47 ± 12.27 years with 55.6% males. The mean systolic and diastolic blood pressure and left ventricular mass decreased significantly in the first 3 (125.44 ± 11.35, 78.51 ± 6.32, 141.94 ± 3.32) and 6 months (121.48 ± 10.63, 72.96 ± 4.21, 138.25 ± 3.12) after renal transplantation compared to the values before the procedure (136.77 ± 14.09, 81.92 ± 9.01, 158.30 ± 3.58 respectively; P < .05). The left ventricular ejection fraction increased significantly at 3 (63.00 ± 6.49) and 6 months (66.11 ± 5.87) compared with preoperative (62.48 ± 5.74; P < .05). Step mean diastolic function also decreased significantly at 3 (1.94) and 6 months (1.81) compared with before transplantation (2.24; P < .05).
  
  
  CONCLUSIONS
  According to our findings, transplantation can correct ejection fraction and systolic and diastolic blood pressure and lead to regression of left ventricular hypertrophy. Diastolic function was improved after transplantation.
authors.affiliation: Urology Research Center, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Salari
authors.forename: A
authors.initials: A
authors.lastname: Monfared
authors.forename: S H S N
authors.initials: SH
authors.lastname: Fahim
authors.forename: M
authors.initials: M
authors.lastname: Khosravi
authors.forename: M
authors.initials: M
authors.lastname: Lebadi
authors.forename: G
authors.initials: G
authors.lastname: Mokhtari
authors.forename: F
authors.initials: F
authors.lastname: Pourreza
authors.forename: M
authors.initials: M
authors.lastname: Shakiba
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D003971:Diastole; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D007492:Iran / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000601:surgery*; D016030:Kidney Transplantation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020127:Recovery of Function; D013318:Stroke Volume; D013599:Systole; D013997:Time Factors; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D016277:Ventricular Function, Left