title: Radiologic outcomes at 5 years after severe ARDS.
abstract: OBJECTIVE
  Few studies have systematically evaluated high-resolution CT (HRCT) imaging of the thorax 5 years after severe ARDS to determine the association between radiologic fi ndings and functional disability. The primary aim of this study was to determine chest radiologic abnormalities at 5 years in survivors of severe ARDS from the University of Toronto ARDS cohort. The secondary aim was to determine the relationship between the observed radiologic abnormalities on HRCT scan and pulmonary symptoms, pulmonary function test abnormalities, and healthrelated quality of life at 5-year follow-up.
  
  
  METHODS
  HRCT scans were obtained in 24 of 64 eligible patients. Three anatomically comparable levels were selected for scoring, and each level was divided into four quadrants. The extent and distribution of individual CT image patterns (ground glass opacifi cation, intense parenchymal opacifi cation, reticular pattern, and decreased attenuation) were also reported.
  
  
  RESULTS
  Eighteen patients (75%) had abnormal fi ndings on HRCT imaging. These findings were minor and in the nondependent lung zones. No correlation was found between radiologic findings and patient symptoms, pulmonary function tests, 6-min walk distances, or heath-related quality of life measures.
  
  
  CONCLUSIONS
  Exercise and functional limitations experienced by survivors of severe ARDS are unlikely to be related to structural lung disease and may be more consistent with extrapulmonary muscle weakness.
authors.affiliation: Department of Medicine, Interdepartmental, University Health Network, Toronto, ON, Canada; Division of Critical Care Medicine, University Health Network, Toronto, ON, Canada. Electronic address: elizabeth.wilcox@utoronto.ca.
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Wilcox
authors.affiliation: Department of Radiology, University Health Network, Toronto, ON, Canada.
authors.forename: Demetris
authors.initials: D
authors.lastname: Patsios
authors.affiliation: Department of Radiology, University Health Network, Toronto, ON, Canada.
authors.forename: Grainne
authors.initials: G
authors.lastname: Murphy
authors.affiliation: Department of Medicine, Interdepartmental, University Health Network, Toronto, ON, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Kudlow
authors.affiliation: Department of Radiology, University Health Network, Toronto, ON, Canada.
authors.forename: Narinder
authors.initials: N
authors.lastname: Paul
authors.affiliation: Department of Medicine, Interdepartmental, University Health Network, Toronto, ON, Canada.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Tansey
authors.affiliation: Department of Medicine, Interdepartmental, University Health Network, Toronto, ON, Canada.
authors.forename: Leslie
authors.initials: L
authors.lastname: Chu
authors.affiliation: Department of Medicine, Interdepartmental, University Health Network, Toronto, ON, Canada.
authors.forename: Andrea
authors.initials: A
authors.lastname: Matte
authors.affiliation: Department of Medicine, Interdepartmental, University Health Network, Toronto, ON, Canada.
authors.forename: George
authors.initials: G
authors.lastname: Tomlinson
authors.affiliation: Department of Medicine, Interdepartmental, University Health Network, Toronto, ON, Canada; Division of Critical Care Medicine, University Health Network, Toronto, ON, Canada.
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Herridge
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011788:Quality of Life; D012128:Respiratory Distress Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016138:Walking / Q000502:physiology