title: Clinical application of interventional renal sympathetic denervation: recommendations of the Austrian Society of Hypertension 2012.
abstract: Increased activity of the sympathetic nervous system plays a major role in the pathophysiology of primary arterial hypertension. Interventional renal sympathetic denervation (RSD) is a novel percutaneous treatment, decreasing sympathetic activity and consecutively blood pressure by ablating sympathetic nervous fibers located in the adventitia of the renal arteries. The procedure has been tested in several clinical trials in patients with resistant hypertension (defined as systolic office blood pressure > 160 mmHg-in diabetic patients > 150 mmHg-treated with ³ 3 antihypertensive drugs) and caused a meaningful blood pressure reduction, lasting for at least 3 years. So far, no major adverse events have been identified; however, data on the long-term consequences are lacking. The present position paper of the Austrian Society of Hypertension is aiming to assist in choosing possible indications for RSD in clinical routine, based on the available evidence in 2012.
authors.affiliation: Kardiologische Abteilung, Klinikum Wels-Grieskirchen, Grieskirchnerstrasse 42, 4600 Wels, Austria. thomas.weber@klinikum-wegr.at
authors.forename: Thomas
authors.initials: T
authors.lastname: Weber
authors.forename: Robert
authors.initials: R
authors.lastname: Zweiker
authors.forename: Bruno
authors.initials: B
authors.lastname: Watschinger
authors.forename: Peter
authors.initials: P
authors.lastname: Grüner
authors.forename: Christian
authors.initials: C
authors.lastname: Koppelstätter
authors.forename: Mathias C
authors.initials: MC
authors.lastname: Brandt
authors.forename: Jörg
authors.initials: J
authors.lastname: Horina
authors.forename: Helmut
authors.initials: H
authors.lastname: Brussee
authors.forename: Katharina
authors.initials: K
authors.lastname: Hohenstein
authors.forename: Thomas
authors.initials: T
authors.lastname: Lambert
authors.forename: Johann
authors.initials: J
authors.lastname: Auer
authors.forename: Uta C
authors.initials: UC
authors.lastname: Hoppe
mesh_terms: D001317:Austria; D006801:Humans; D006977:Hypertension, Renal / Q000601:surgery*; D007668:Kidney / Q000294:innervation* / Q000601:surgery*; D017410:Practice Guidelines as Topic; D013562:Sympathectomy / Q000379:methods* / Q000592:standards*