title: EHDs meet the retromer: Complex regulation of retrograde transport.
abstract: Retrograde trafficking mediates the transport of endocytic membranes from endosomes to the trans-Golgi network (TGN). Dysregulation of these pathways can result in multiple ailments, including late-onset Alzheimer disease. One of the key retrograde transport regulators, the retromer complex, is tightly controlled by many factors, including the C-terminal Eps15 homology domain (EHD) proteins. This mini-review focuses on recent findings and discusses the regulation of the retromer complex by EHD proteins and the novel EHD1 interaction partner, Rabankyrin-5 (Rank-5).
authors.affiliation: Department of Biochemistry and Molecular Biology and Eppley Cancer Center; University of Nebraska Medical Center; Omaha, NE USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Naava
authors.initials: N
authors.lastname: Naslavsky
authors.forename: Steve
authors.initials: S
authors.lastname: Caplan