title: Time course of right ventricular remodeling after percutaneous atrial septal defect closure: assessment of regional deformation properties with two-dimensional strain and strain rate imaging.
abstract: BACKGROUND
  Quantitative assessment of the right ventricular (RV) function in atrial septal defect (ASD) patients before and after closure remains difficult. The aim of this study was to assess the regional RV function in ASD patients, to evaluate the extent and time course of RV remodeling following ASD closure, and to investigate whether any regional difference exists in RV remodeling.
  
  
  METHODS
  Twenty patients with ASD and 20 age-matched controls were included. All underwent standard echocardiography and two-dimensional strain (S) and strain rate (SR) imaging by speckle tracking before, and 24 hours and 1 month after the defect closure.
  
  
  RESULTS
  Right ventricular S was higher in ASD patients except apical lateral segment S, which was lower when compared with controls. There was no difference in RV SR between ASD patients and controls. RV septal S and SR, and lateral SR decreased in 24 hours after the procedure and remained the same at 1 month. RV lateral basal and mid S decreased and apical S increased in 24 hours after the closure. All 3 segments showed some more increase at 1 month. RV apical S showed strong correlations with systolic pulmonary artery pressure and global RV systolic function indices.
  
  
  CONCLUSIONS
  Chronic volume overload in ASD patients causes alterations in RV deformation. Percutaneous closure results in rapid remodeling and normalization of RV deformation. The major geometrical and deformational changes are completed in 24 hours. Lateral wall S seems to reflect the RV deformational changes due to volume loading and unloading better than SR in ASD patients.
authors.affiliation: Department of Cardiology, Yeditepe University Hospital, İstanbul, Turkey. elif.ebu@gmail.com
authors.forename: Elif
authors.initials: E
authors.lastname: Eroglu
authors.forename: Sinem Deniz
authors.initials: SD
authors.lastname: Cakal
authors.forename: Beytullah
authors.initials: B
authors.lastname: Cakal
authors.forename: Cihan
authors.initials: C
authors.lastname: Dundar
authors.forename: Gokhan
authors.initials: G
authors.lastname: Alici
authors.forename: Birol
authors.initials: B
authors.lastname: Ozkan
authors.forename: Mehmet Vefik
authors.initials: MV
authors.lastname: Yazicioglu
authors.forename: Kursat
authors.initials: K
authors.lastname: Tigen
authors.forename: Ali Metin
authors.initials: AM
authors.lastname: Esen
mesh_terms: D000328:Adult; D013504:Cardiovascular Surgical Procedures / Q000009:adverse effects; D004452:Echocardiography / Q000379:methods*; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D006801:Humans; D008297:Male; D019651:Plastic Surgery Procedures / Q000009:adverse effects*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*