title: Very old adults with better memory function have higher low-density lipoprotein cholesterol levels and lower triglyceride to high-density lipoprotein cholesterol ratios: KOCOA Project.
abstract: We cross-sectionally examined which lipid profiles are associated with better cognitive function among those aged 80 and older, free of dementia (Clinical Dementia Rating ≤0.5), functionally independent, and community-dwelling. Our cohort consisted of 193 participants from the "Keys to Optimal Cognitive Aging (KOCOA) Project", a prospective cohort study in Okinawa, Japan. Higher low-density lipoprotein cholesterol levels and lower triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratios were associated with higher scores in memory performance after controlling for confounders. Further research is required to clarify the associations among LDL-C levels, TG/HDL-C ratios, and healthy cognitive aging.
authors.affiliation: Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA. katsumat@ohsu.edu
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Katsumata
authors.forename: Hidemi
authors.initials: H
authors.lastname: Todoriki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Higashiuesato
authors.forename: Shotoku
authors.initials: S
authors.lastname: Yasura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ohya
authors.forename: D Craig
authors.initials: DC
authors.lastname: Willcox
authors.forename: Hiroko H
authors.initials: HH
authors.lastname: Dodge
mesh_terms: D000369:Aged, 80 and over; D008078:Cholesterol, LDL / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007564:Japan; D008075:Lipoproteins, HDL / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008568:Memory / Q000502:physiology*; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood*
chemical_list: D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D014280:Triglycerides