title: Biologically active alkamide from the lichen Stereocaulon alpinum.
abstract: The presence of an alkamide in lichens is reported for the first time. The alkamide was isolated from Stereocaulon alpinum Laur. and identified through spectroscopic analysis as 9-cis-octa-decenamide (1). With reference to previously known activity of alkamides from both the plant and animal kingdoms on inflammatory processes, 1 was tested for in vitro inhibitory activity against the key enzymes of the major pathways involved in arachidonate metabolism. The compound was shown to exhibit moderate dose-dependent inhibitory activity against cyclooxygenase from sheep seminal vesicle microsomes (IC(50) = 64.3 μM) whilst showing only slight activity against 5-lipoxygenase from porcine leucocytes.
authors.affiliation: Dept. of Pharmacy, University of Iceland, Reykjavik, Iceland.
authors.forename: K
authors.initials: K
authors.lastname: Ingólfsdóttir
authors.forename: S R
authors.initials: SR
authors.lastname: Gissurarson
authors.forename: A
authors.initials: A
authors.lastname: Nenninger
authors.forename: A
authors.initials: A
authors.lastname: Neszmelyi
authors.forename: B
authors.initials: B
authors.lastname: Wiedemann
authors.forename: H
authors.initials: H
authors.lastname: Wagner