title: Screening of plant extracts and plant constituents for calcium-channel blocking activity.
abstract: Various constituents isolated from plants with described or suggested antihypertensive, spasmolytic or diuretic activity were tested in an in in vitro-guinea pig papillary muscle model for possible calcium-channel blocking activity. Among the isolated compounds some phenylpropanoids of essential oil (e.g. apiol), mono- and sesquiterpene derivatives (e.g. bisabolol-oxide A), naphthoquinones (e.g. juglone, 7-methyljuglone, plumbagin, garlic constituents), some phenolics and alkaloids showed good to moderate activity (IC(50):15-100 μM). Some of the tested compounds caused a prolonged duration of the contraction, suggesting an additional K(+)-channel blocking effect.
authors.affiliation: Institut für Pharmazeutische Biologie der Universität München, München, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Neuhaus-Carlisle
authors.forename: W
authors.initials: W
authors.lastname: Vierling
authors.forename: H
authors.initials: H
authors.lastname: Wagner