title: Lipophilic silver nanoparticles and their polymeric entrapment into targeted-PEG-based micelles for the treatment of glioblastoma.
abstract: A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μM) has been found on glioblastoma cell lines.
authors.affiliation: Dipartimento di Chimica Organica, "A. Mangini", University, Viale Risorgimento 4, 40136 Bologna, Italy.
authors.forename: Erica
authors.initials: E
authors.lastname: Locatelli
authors.forename: Francesca
authors.initials: F
authors.lastname: Broggi
authors.forename: Jessica
authors.initials: J
authors.lastname: Ponti
authors.forename: Patrick
authors.initials: P
authors.lastname: Marmorato
authors.forename: Fabio
authors.initials: F
authors.lastname: Franchini
authors.forename: Stefano
authors.initials: S
authors.lastname: Lena
authors.forename: Mauro Comes
authors.initials: MC
authors.lastname: Franchini
mesh_terms: D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use*; D053769:Nanocapsules / Q000737:chemistry* / Q000627:therapeutic use / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry*; D012834:Silver / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D004337:Drug Carriers; D053769:Nanocapsules; D012834:Silver; D011092:Polyethylene Glycols