title: Stereoselective approach to cis-2,3-disubstituted piperidines via reduction of N-acyliminium ion intermediate: enantioselective synthesis of (+)-(2S,3S)-CP-99,994.
abstract: A very simple and efficient stereoselective approach to cis-2,3-disubstituted piperidines via the reduction of N-acyliminium ion intermediates is described. Application of this methodology is exemplified by the enantioselective total synthesis of (+)-(2S,3S)-CP-99,994.
authors.affiliation: Mendeleev Block, Department of Chemistry, Indian Institute of Science Education and Research, Pune, Maharashtra, 411008, India.
authors.forename: Prakash R
authors.initials: PR
authors.lastname: Sultane
authors.forename: Ramakrishna G
authors.initials: RG
authors.lastname: Bhat
mesh_terms: D060326:Chemistry Techniques, Synthetic; D007097:Imines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D007097:Imines; D007659:Ketones; D010880:Piperidines; C080755:3-(2-methoxybenzylamino)-2-phenylpiperidine