title: One-step patterning of hollow microstructures in paper by laser cutting to create microfluidic analytical devices.
abstract: In this paper, we report a simple, low-cost method for rapid, highly reproductive fabrication of paper-based microfluidics by using a commercially available, minitype CO(2) laser cutting/engraving machine. This method involves only one operation of cutting a piece of paper by laser according to a predesigned pattern. The hollow microstructures formed in the paper are used as the 'hydrophobic barriers' to define the hydrophilic flowing paths. A typical paper device on a 4 cm × 4 cm piece of paper can be fabricated within ∼7-20 s; it is ready for use once the cutting process is finished. The main fabrication parameters such as the applied current and cutting rate of the laser were optimized. The fabrication resolution and multiplexed analytical capability of the hollow microstructure-patterned paper were also characterized.
authors.affiliation: College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China.
authors.forename: Jinfang
authors.initials: J
authors.lastname: Nie
authors.forename: Yuanzhi
authors.initials: Y
authors.lastname: Liang
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shangwang
authors.initials: S
authors.lastname: Le
authors.forename: Dunnan
authors.initials: D
authors.lastname: Li
authors.forename: Songbai
authors.initials: S
authors.lastname: Zhang
mesh_terms: D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D005949:Glucose Oxidase / Q000737:chemistry; D006735:Horseradish Peroxidase / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007834:Lasers; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods*; D049329:Nanostructures; D010209:Paper; D012710:Serum Albumin, Bovine / Q000032:analysis* / Q000737:chemistry
chemical_list: D012710:Serum Albumin, Bovine; D005949:Glucose Oxidase; D006735:Horseradish Peroxidase; D005947:Glucose