title: [Juvenile primary lung cancer in a 17-year-old girl as a 2nd malignant neoplasm after osteosarcoma treatment in childhood].
abstract: METHODS
  The patient was a 17-year-old girl. She underwent treatment for osteosarcoma when she was around 10 ~ 11 years old. A follow-up chest computed tomography(CT) revealed one small pulmonary nodule 6 years later. The orthopedist thought it was metastasis. The patient was referred to our division and treated with thoracoscopic partial resection. The final pathological diagnosis was a primary lung adenocarcinoma.
  
  
  CONCLUSIONS
  This case is unique because the patient is juvenile and had a history of another cancer, i.e., osteosarcoma. Her primary lung cancer is a 2nd malignancy. The incidence of 2nd malignant neoplasm is one of the significant late effects of pediatric cancer treatment. When pulmonary lesions are detected in young patient with histories of neoplasms, primary lung cancer as a 2nd malignant neoplasm as well as pulmonary metastasis from 1st neoplasm, should be considered as differential diagnosis.
authors.affiliation: Department of Cardiothoracic Surgery, The University of Tokyo, Tokyo, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Konoeda
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Murakawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sano
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Kawashima
authors.forename: Jun
authors.initials: J
authors.lastname: Nakajima
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000293:Adolescent; D001859:Bone Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012516:Osteosarcoma / Q000473:pathology*