title: Oxindole derivatives: synthesis and antiglycation activity.
abstract: Oxindole derivatives 3-25 have been synthesized from commercially available oxindole by refluxing with different aromatic aldehydes in good yields. Their in vitro antiglycation potential has been evaluated. They showed a varying degree of antiglycation activity with IC50 values ranging between 150.4 - 856.7 µM. 3-[(3-Chlorophenyl)methylidene]- 1,3-dihydro-2H-indol-2-one (IC50 = 150.4 ± 2.5 µM) is the most active compound among the series, better than the standard rutin with an IC50 value 294.5 ± 1.50 µM. The structures of the compounds were elucidated by 1H-NMR and mass spectroscopy and elemental analysis. A limited structure-activity relationship has been developed.
authors.affiliation: H.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. khalid.khan@iccs.edu
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Momin
authors.initials: M
authors.lastname: Khan
authors.forename: Nida
authors.initials: N
authors.lastname: Ambreen
authors.forename: Muhammad
authors.initials: M
authors.lastname: Taha
authors.forename: Fazal
authors.initials: F
authors.lastname: Rahim
authors.forename: Saima
authors.initials: S
authors.lastname: Rasheed
authors.forename: Sumayya
authors.initials: S
authors.lastname: Saied
authors.forename: Humaira
authors.initials: H
authors.lastname: Shafi
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D004305:Dose-Response Relationship, Drug; D006031:Glycosylation / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D000078183:Oxindoles
chemical_list: D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole