title: Spinal cord: motor neuron diseases.
abstract: Spinal cord motor neuron diseases affect lower motor neurons in the ventral horn. This article focuses on the most common spinal cord motor neuron disease, amyotrophic lateral sclerosis, which also affects upper motor neurons. Also discussed are other motor neuron diseases that only affect the lower motor neurons. Despite the identification of several genes associated with familial amyotrophic lateral sclerosis, the pathogenesis of this complex disease remains elusive.
authors.affiliation: Department of Neurology, University of Chicago Medical Center, Chicago, IL 60637, USA. krezania@neurology.bsd.uchicago.edu
authors.forename: Kourosh
authors.initials: K
authors.lastname: Rezania
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Roos
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D016472:Motor Neuron Disease / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D013116:Spinal Cord / Q000473:pathology*; D013118:Spinal Cord Diseases / Q000150:complications* / Q000175:diagnosis / Q000235:genetics