title: Preliminary experience of CyberKnife treatment of primary non-small cell lung cancer.
abstract: OBJECTIVE
  Provide the effectiveness of treatment protocol, radiotherapy plan, technique, and early clinical results of inoperable primary non-small cell lung cancer (NSCLC) in patients who received CyberKnife treatment at Ramathibodi Hospital.
  
  
  METHODS
  Six cases of inoperable primary NSCLC patients were evaluated for tumor response after having received CyberKnife treatment. The prescribed radiation dose was 45 gray (Gy) in three consecutive fractions for peripherally located tumor and 50 Gy in five fractions within two weeks for centrally located tumor (biological equivalent dose, BED, 112.5 Gy 10, and 100 Gy 10, respectively). The response to treatment was evaluated from roentgenographic study during follow-up period along with clinical outcome and adverse event.
  
  
  RESULTS
  Overall response after the treatment was demonstrated in five cases with roentgenographic complete response (CR, disappearance of tumor) and partial response (PR, 50% decrease in size) in two and three cases, respectively without any severe adverse event. The treatment planning parameters demonstrated the effectiveness of radiation dose homogeneity and conformity coverage of the target volume.
  
  
  CONCLUSIONS
  This preliminary report has provided the effectiveness of treatment plan and local tumor controlled without severe adverse event for primary inoperable NSCLC patients receiving CyberKnife treatment.
authors.affiliation: Radiation Oncology Division, Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand. swangsilpa@yahoo.com
authors.forename: Thiti
authors.initials: T
authors.lastname: Swangsilpa
authors.forename: Pornpan
authors.initials: P
authors.lastname: Yongvithisatid
authors.forename: Kumutinee
authors.initials: K
authors.lastname: Pairat
authors.forename: Patchareporn
authors.initials: P
authors.lastname: Dechsupa
authors.forename: Mantana
authors.initials: M
authors.lastname: Dhanachai
authors.forename: Somjai
authors.initials: S
authors.lastname: Dangprasert
authors.forename: Ladawan
authors.initials: L
authors.lastname: Narkwong
authors.forename: Chomporn
authors.initials: C
authors.lastname: Sitathanee
authors.forename: Putipun
authors.initials: P
authors.lastname: Puataweepong
authors.forename: Parmon
authors.initials: P
authors.lastname: Puddhikarant
authors.forename: Chuleeporn
authors.initials: C
authors.lastname: Jiarpinitnun
authors.forename: Patamintita
authors.initials: P
authors.lastname: Witoonpanich
authors.forename: Taweesak
authors.initials: T
authors.lastname: Ukhumpun
authors.forename: Juthamat
authors.initials: J
authors.lastname: Khaophong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D013785:Thailand; D016896:Treatment Outcome