title: [Incidence of polynuclear zygotes and pregnancy rate after short coincubation of gametes in in vitro fertilization].
abstract: OBJECTIVE
  To explore the relationship of the incidence of polynuclear zygotes with clinical pregnancy after short coincubation of gametes in in vitro fertilization (IVF).
  
  
  METHODS
  We retrospectively analyzed 3 862 cases of short gamete coincubation IVF, which were divided into six groups according to the percentage of polynuclear zygotes: 0,1-10%, 11-20%, 21-30%, 31-50%, 41-50%, and > or = 51%. We compared the rates of clinical pregnancy, implantation and abortion among the six groups.
  
  
  RESULTS
  No statistically significant differences were found in the patients'age, dose of gonadotropin, peak E2, number of follicles at the hCG trigger, and number of oocytes retrieved among the six groups. The 1-10% group showed higher rates of pregnancy and implantation, while the > or = 51% group exhibited lower rates of pregnancy and implantation but a higher rate of abortion than the other groups, none with significant differences (P > 0.05).
  
  
  CONCLUSIONS
  The incidence of polynuclear zygotes after short coincubation of gametes in IVF cannot serve as a prognostic indicator of the outcome of clinical pregnancy.
authors.affiliation: Center of Reproductive Medicine, Drum Tower Hospital Affiliated to Nanjing University School of Medicine, Nanjing, Jiangsu 210008, China.
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Xu
authors.forename: Hai-Xiang
authors.initials: HX
authors.lastname: Sun
authors.forename: Ning-Yuan
authors.initials: NY
authors.lastname: Zhang
authors.forename: Lin-Jun
authors.initials: LJ
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000328:Adult; D010064:Embryo Implantation; D005260:Female; D005307:Fertilization in Vitro; D005854:Germ Cells; D006801:Humans; D008297:Male; D009865:Oocytes; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D015053:Zygote