title: Epigenetics and regeneration.
abstract: During newt lens regeneration a unique transdifferentiation event occurs. In this process, dorsal iris pigmented epithelial cells transdifferentiate into lens cells. This system should provide a new insight into cellular plasticity in basic and applied research. Recently, a series of approaches to study epigenetic reprogramming during transdifferentiation have been performed. In this review, we introduce the regulation of dynamic regulation of core-histone modifications and the emergence of an oocyte-type linker histone during transdifferentiation. Finally, we show supporting evidence that there are common strategies of reprogramming between newt somatic cell in transdifferentiation and oocytes after somatic cell nuclear transfer.
authors.affiliation: Institute of Protein Research, Osaka University, Osaka, Japan. makinobu@protein.osaka-u.ac.jp
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Maki
authors.forename: Hironobu
authors.initials: H
authors.lastname: Kimura
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D054338:Cell Transdifferentiation; D065150:Cellular Reprogramming; D057890:Epigenomics; D006657:Histones / Q000502:physiology; D007908:Lens, Crystalline / Q000502:physiology*; D008969:Molecular Sequence Data; D012038:Regeneration; D012455:Salamandridae / Q000502:physiology*
chemical_list: D006657:Histones