title: SVSVGMKPSPRP: a broad range adhesion peptide.
abstract: BACKGROUND
  A combinatorial phage display approach was previously used to evolve a 12-mer peptide (SVSVGMKPSPRP) with the highest affinity for different semiconductor surfaces. The discovery of the multiple occurrences of the SVSVGMKPSPRP sequence in an all-against-all basic local alignment search tool search of PepBank sequences was unexpected, and a Google search using the peptide sequence recovered 58 results concerning 12 patents and 16 scientific publications. The number of patent and articles indicates that the peptide is perhaps a broad range adhesion peptide.
  
  
  METHODS
  To evaluate peptide properties, we conducted a study to investigate peptide adhesion on different inorganic substrates by mass spectrometry and atomic force microscopy for gold, carbon nanotubes, cobalt, chrome alloy, titanium, and titanium alloy substrates.
  
  
  RESULTS
  Our results showed that the peptide has a great potential as a linker to functionalize metallic surfaces if specificity is not a key factor. This peptide is not specific to a particular metal surface, but it is a good linker for the functionalization of a wide range of metallic materials.
  
  
  CONCLUSIONS
  The fact that this peptide has the potential to adsorb on a large set of inorganic surfaces suggests novel promising directions for further investigation. Affinity determination of SVSVGMKPSPRP peptide would be an important issue for eventual commercial uses.
authors.affiliation: Université Montpellier 2, Laboratoire Charles Coulomb UMR 5221, F-34095, Montpellier, France.
authors.forename: Elias
authors.initials: E
authors.lastname: Estephan
authors.forename: Jérôme
authors.initials: J
authors.lastname: Dao
authors.forename: Marie-Belle
authors.initials: MB
authors.lastname: Saab
authors.forename: Ivan
authors.initials: I
authors.lastname: Panayotov
authors.forename: Marta
authors.initials: M
authors.lastname: Martin
authors.forename: Christian
authors.initials: C
authors.lastname: Larroque
authors.forename: Csilla
authors.initials: C
authors.lastname: Gergely
authors.forename: Frédéric J G
authors.initials: FJ
authors.lastname: Cuisinier
authors.forename: Bernard
authors.initials: B
authors.lastname: Levallois
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D015815:Cell Adhesion Molecules / Q000737:chemistry*; D008422:Materials Testing; D008670:Metals / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011485:Protein Binding
chemical_list: D001672:Biocompatible Materials; D015815:Cell Adhesion Molecules; D008670:Metals; D010455:Peptides