title: Relationship between serum adipocyte fatty acid-binding protein and endothelial/hemostatic markers in dyslipidemic subjects.
abstract: OBJECTIVE
  Some findings support the role of serum adipocyte fatty acid-binding protein (A-FABP) as a key pro-inflammatory mediator that links obesity with cardiovascular diseases. The aim of the study was to evaluate the association of A-FABP with endothelial/hemostatic markers [von Willebrand factor (vWF), plasminogen activator inhibitor-1 (PAI-1), tissue-plasminogen activator (t-PA), soluble intercellular cell adhesion molecule-1 (s-ICAM-1) and soluble vascular cell adhesion molecule-1 (s-VCAM-1)] in asymptomatic dyslipidemic subjects.
  
  
  METHODS
  We examined 105 dyslipidemic patients (with apolipoprotein B concentration ≥1.2 g/l and/or triglyceride (TG) concentration ≥1.5 mmol/l) without clinical manifestation of atherosclerosis and 50 normolipidemic healthy subjects, who served as a control group. Except of endothelial/hemostatic markers, anthropometric and lipid parameters, markers of insulin resistance and inflammation were assessed.
  
  
  RESULTS
  In dyslipidemic patients, A-FABP positively correlated with age (p<0.05), TG (p<0.05), insulin (p<0.05), homeostatic model assessment (HOMA) index (p<0.05), body mass index (p<0.001), waist circumference (p<0.05), high sensitivity C reactive protein (p<0.01), and vWF (p<0.05) and negatively with male gender (p<0.05). There were no correlations between A-FABP and PAI-1, t-PA, s-VCAM-1 or s-ICAM-1. By using linear multivariate regression analysis the positive association between A-FABP and vWF was independent of age, gender, insulin resistance, and visceral obesity.
  
  
  CONCLUSIONS
  Study displayed an independent positive association of A-FABP with vWF in clinically asymptomatic dyslipidemic subjects. Contribution of A-FABP in the process of endothelial dysfunction could help to explain the role of obesity in cardiovascular damage.
authors.affiliation: 3rd Department of Internal Medicine, University Hospital Olomouc, Czech Republic. david.karasek@fnol.cz
authors.forename: David
authors.initials: D
authors.lastname: Karasek
authors.forename: Helena
authors.initials: H
authors.lastname: Vaverkova
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Frysak
authors.forename: Jiri
authors.initials: J
authors.lastname: Orsag
authors.forename: Dalibor
authors.initials: D
authors.lastname: Novotny
authors.forename: Milan
authors.initials: M
authors.lastname: Halenka
authors.forename: Ludek
authors.initials: L
authors.lastname: Slavik
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology*; D004730:Endothelium, Vascular / Q000378:metabolism*; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D012307:Risk Factors; D010959:Tissue Plasminogen Activator / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D015415:Biomarkers; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D019010:Vascular Cell Adhesion Molecule-1; D014841:von Willebrand Factor; D018799:Intercellular Adhesion Molecule-1; D010959:Tissue Plasminogen Activator