title: [Current situation of toxicity classification of Chinese materia medica and its research thoughts].
abstract: Toxicity of Chinese materia medica (CMM) is an important part of Chinese herbal nature theory. In clinical application, the dosage, time limitation and compatibility of CMM is mainly determined by toxicity. At present, there is no uniform toxicity classification standard for the evaluation of Chinese herbal toxicity. Therefore, it is significant to research toxicity classification of CMM. The current situation of toxicity classification of CMM is reviewed in this paper, and proposed research thoughts are as follows: the measurement of toxicity parameters, the confirmation of poisoning target organs, the investigation on toxic mechanism by serum pharmacology and toxicokinetics, the comprehensive evaluation on toxicity based on quantitative theory.
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. wenyansun@yahoo.com.cn
authors.forename: Wenyan
authors.initials: W
authors.lastname: Sun
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Hou
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Yuelan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Shuofeng
authors.initials: S
authors.lastname: Zhang
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Chang
authors.forename: Jianning
authors.initials: J
authors.lastname: Sun
mesh_terms: D000818:Animals; D035843:Biomedical Research; D002681:China; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000145:classification* / Q000266:history / Q000633:toxicity*; D049690:History, Ancient; D006801:Humans; D008419:Materia Medica / Q000032:analysis / Q000145:classification* / Q000266:history / Q000633:toxicity*; D008516:Medicine, Chinese Traditional / Q000009:adverse effects; D051379:Mice; D051381:Rats
chemical_list: D004365:Drugs, Chinese Herbal; D008419:Materia Medica