title: Efficacy of leukocyte- and platelet-rich fibrin in wound healing:  a randomized controlled clinical trial.
abstract: BACKGROUND
  Application of platelet concentrates to wounds could speed healing. Leukocyte- and platelet-rich fibrin, a relatively recent development, stands out from the other preparations. This prospective, randomized, controlled clinical trial studied the rate of healing of postoperative hand wounds after a single application of leukocyte- and platelet-rich fibrin.
  
  
  METHODS
  Eligible patients were healthy individuals older than 18 years who had been scheduled for elective McCash (open palm) surgery for Dupuytren disease at the Plastic and Hand Surgery Department of Nice's University Hospital between August of 2007 and February of 2010. The control group received the reference care of petroleum jelly mesh (Vaselitulle), and test patients had leukocyte- and platelet-rich fibrin applied. The primary endpoint was healing delay measured in postoperative days. Secondary endpoints included pain, bleeding, and wound exudate. The trial was carried out as a single-blind trial.
  
  
  RESULTS
  Among the 68 randomized patients, 33 patients in the leukocyte- and platelet-rich fibrin group and 31 in the Vaselitulle group were analyzed. Primary endpoint analysis showed a median healing delay of 24 days (interquartile range, 18 to 28 days) for the fibrin group and 29 days (interquartile range, 26 to 35 days) for the Vaselitulle group (p = 0.014, log-rank test). Postoperative pain assessment, bleeding, and exudate were always lower for the fibrin group, but not significantly so.
  
  
  CONCLUSIONS
  The authors trial demonstrates that a single leukocyte- and platelet-rich fibrin application on fresh postoperative hand wounds shows a median improvement of 5 days in comparison with the standard treatment.
  
  
  METHODS
  Therapeutic, II.
authors.affiliation: Nice, France From the Plastic Reconstructive and Aesthetic Surgery Department, St. Roch University Hospital of Nice, and the Clinical Research Department, Cimiez University Hospital of Nice.
authors.forename: Bérengère
authors.initials: B
authors.lastname: Chignon-Sicard
authors.forename: Charalambos A
authors.initials: CA
authors.lastname: Georgiou
authors.forename: Eric
authors.initials: E
authors.lastname: Fontas
authors.forename: Sylvain
authors.initials: S
authors.lastname: David
authors.forename: Pierre
authors.initials: P
authors.lastname: Dumas
authors.forename: Tarik
authors.initials: T
authors.lastname: Ihrai
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Lebreton
mesh_terms: D000368:Aged; D001458:Bandages; D001792:Blood Platelets; D004387:Dupuytren Contracture / Q000601:surgery*; D005122:Exudates and Transudates; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006225:Hand / Q000601:surgery*; D006801:Humans; D053208:Kaplan-Meier Estimate; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D011446:Prospective Studies; D016037:Single-Blind Method; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
chemical_list: D005337:Fibrin