title: Long-term survival and healthcare utilization outcomes attributable to sepsis and pneumonia.
abstract: BACKGROUND
  Hospital associated infections are major problems, which are increasing in incidence and very costly. However, most research has focused only on measuring consequences associated with the initial hospitalization. We explored the long-term consequences of infections in elderly Medicare patients admitted to an intensive care unit (ICU) and discharged alive, focusing on: sepsis, pneumonia, central-line-associated bloodstream infections (CLABSI), and ventilator-associated pneumonia (VAP); the relationships between the infections and long-term survival and resource utilization; and how resource utilization was related to impending death during the follow up period.
  
  
  METHODS
  Clinical data and one year pre- and five years post-index hospitalization Medicare records were examined. Hazard ratios (HR) and healthcare utilization incidence ratios (IR) were estimated from state of the art econometric models. Patient demographics (i.e., age, gender, race and health status) and Medicaid status (i.e., dual eligibility) were controlled for in these models.
  
  
  RESULTS
  In 17,537 patients, there were 1,062 sepsis, 1,802 pneumonia, 42 CLABSI and 52 VAP cases. These subjects accounted for 62,554 person-years post discharge. The sepsis and CLABSI cohorts were similar as were the pneumonia and VAP cohorts. Infection was associated with increased mortality (sepsis HR = 1.39, P < 0.01; and pneumonia HR = 1.58, P < 0.01) and the risk persisted throughout the follow-up period. Persons with sepsis and pneumonia experienced higher utilization than controls (e.g., IR for long-term care utilization for those with sepsis ranged from 2.67 to 1.93 in years 1 through 5); and, utilization was partially related to impending death.
  
  
  CONCLUSIONS
  The infections had significant and lasting adverse consequences among the elderly. Yet, many of these infections may be preventable. Investments in infection prevention interventions are needed in both community and hospitals settings.
authors.affiliation: RAND Corporation, 20 Park Plaza. Suite 920, Boston, MA 02116, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Dick
authors.forename: Hangsheng
authors.initials: H
authors.lastname: Liu
authors.forename: Jack
authors.initials: J
authors.lastname: Zwanziger
authors.forename: Eli
authors.initials: E
authors.lastname: Perencevich
authors.forename: E Yoko
authors.initials: EY
authors.lastname: Furuya
authors.forename: Elaine
authors.initials: E
authors.lastname: Larson
authors.forename: Monika
authors.initials: M
authors.lastname: Pogorzelska-Maziarz
authors.forename: Patricia W
authors.initials: PW
authors.lastname: Stone
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055499:Catheter-Related Infections / Q000453:epidemiology / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D006296:Health Services / Q000706:statistics & numerical data*; D006801:Humans; D007345:Insurance Claim Review / Q000706:statistics & numerical data; D008297:Male; D006278:Medicare; D008875:Middle Aged; D017059:Models, Econometric; D017063:Outcome Assessment, Health Care; D010351:Patient Discharge; D053717:Pneumonia, Ventilator-Associated / Q000453:epidemiology / Q000401:mortality; D018805:Sepsis / Q000453:epidemiology / Q000401:mortality; D017741:Survivors; D014481:United States / Q000453:epidemiology