title: Reduced alpha and exaggerated theta power during the resting-state EEG in fragile X syndrome.
abstract: This study characterizes the resting-state EEG in males with fragile X syndrome to reveal abnormalities in oscillatory brain dynamics. Analyses of the eyes-closed EEG epochs showed that the resting-state EEG in FXS can be characterized by elevated relative theta power (4-8 Hz) and reduced relative upper-alpha power (10-12 Hz). Although preliminary, these findings suggest that the well-documented imbalance in excitatory/inhibitory cortical circuit activity in FXS can be revealed the level of oscillatory behavior at the scalp. A next step for future studies is linking the EEG resting-state indices to cognitive and behavioral measures.
authors.affiliation: Leiden University, Institute of Psychology, The Netherlands. m.j.w.vandermolen@gmail.com
authors.forename: Melle J W
authors.initials: MJ
authors.lastname: Van der Molen
authors.forename: Maurits W
authors.initials: MW
authors.lastname: Van der Molen
mesh_terms: D000328:Adult; D000513:Alpha Rhythm / Q000502:physiology*; D000704:Analysis of Variance; D001931:Brain Mapping; D016022:Case-Control Studies; D004569:Electroencephalography; D005600:Fragile X Syndrome / Q000503:physiopathology*; D006801:Humans; D008297:Male; D012146:Rest; D013057:Spectrum Analysis; D013826:Theta Rhythm / Q000502:physiology*; D055815:Young Adult