title: Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives.
abstract: Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg yolk angiogenesis model. A comparative study with pure thalidomide (NKTA) has also been performed to describe the efficacy of these derivatives in blocking angiogenesis. NK037, NK041 and NK042 were equally potent in blocking egg yolk angiogenesis and the anti-angiogenesis effect was higher than NKTA suggesting the efficacy of these three derivatives in blocking angiogenesis when compare to control. Other two derivatives NK0139A and NK0148 showed effect less than NKTA and stronger than control in ex vivo angiogenesis.
authors.affiliation: Vascular Biology Lab, AU-KBC Research Centre, MIT Campus, Anna University, Chennai, Tamil Nadu 600 044, India.
authors.forename: Shunmugam
authors.initials: S
authors.lastname: Nagarajan
authors.forename: Syamantak
authors.initials: S
authors.lastname: Majumder
authors.forename: Upendra
authors.initials: U
authors.lastname: Sharma
authors.forename: Saranya
authors.initials: S
authors.lastname: Rajendran
authors.forename: Neeraj
authors.initials: N
authors.lastname: Kumar
authors.forename: Suvro
authors.initials: S
authors.lastname: Chatterjee
authors.forename: Bikram
authors.initials: B
authors.lastname: Singh
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry*; D002642:Chick Embryo; D004530:Egg Yolk / Q000187:drug effects; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D020533:Angiogenesis Inhibitors; D001562:Benzimidazoles; D052160:Benzothiazoles; D010797:Phthalimides; C037431:phthalimide; C031000:benzimidazole; C005465:benzothiazole