title: Mean platelet volume associated with aortic distensibility, chronic inflammation, and diabetes in patients with stable coronary artery disease.
abstract: We aimed to assess the effective factors on high mean platelet volume (MPV) in patients with stable coronary artery disease (CAD). A total of 411 patients (247 males and 164 females; mean age: 61.7 ± 9.9 years) with angiographically proven CAD were included. The patients were divided into 2 groups according to the median MPV value (MPVlow group <9.5 fL and MPVhigh group ≥9.5 fL). The SYNTAX score, high sensitive C-reactive protein (hsCRP) levels, and frequencies of diabetes and hypertension were higher in MPVhigh group compared to MPVlow group. Aortic distensibility (AD) and platelet count of patients in MPVhigh group were lower than patients in MPVlow group (P < .05, for all). Multivariate linear regression analysis showed that MPV was independently related with diabetes (β = 0.135, P = .007), hsCRP (β = 0.259, P < .001), platelet count (β = -0.144, P < .001), and AD (β = -0.425, P < .001). High MPV value is independently related to AD, as well as diabetes, hsCRP, and platelet count in patients with stable CAD.
authors.affiliation: 1Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey.
authors.forename: Durmuş Yıldıray
authors.initials: DY
authors.lastname: Şahin
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Arafat
authors.initials: A
authors.lastname: Yıldırım
authors.forename: Rabia Eker
authors.initials: RE
authors.lastname: Akıllı
authors.forename: Nermin Yıldız
authors.initials: NY
authors.lastname: Koyunsever
authors.forename: Betül
authors.initials: B
authors.lastname: Özaltun
authors.forename: Gökhan
authors.initials: G
authors.lastname: Gözübüyük
authors.forename: Ali
authors.initials: A
authors.lastname: Kıvrak
authors.forename: Murat
authors.initials: M
authors.lastname: Çaylı
mesh_terms: D001011:Aorta / Q000473:pathology*; D001783:Blood Flow Velocity; D001792:Blood Platelets / Q000473:pathology*; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology; D003920:Diabetes Mellitus / Q000097:blood* / Q000473:pathology; D004452:Echocardiography; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000473:pathology; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged