title: Intralenticular neovascularization in a cataractous crystalline lens.
abstract: BACKGROUND
  Neovascularization can occur in various ocular structures including the retina, iris, anterior chamber angle and cornea; however, it rarely occurs in the crystalline lens. Neovascularization results secondary to hypoxic conditions within the eye. A natural balance of angiogenic and antiangiogenic factors are critical for the eye to prevent the formation of neovascularization. Various factors can upset this natural balance, resulting in angiogenesis. Due to the lack of an intrinsic blood supply, intralenticular neovascularization is rare.
  
  
  METHODS
  A 61-year-old black male presented with a previous diagnosis of proliferative diabetic retinopathy (PDR). His ocular history included cataract extraction in the left eye (OS) and tractional retinal detachment in both eyes that was surgically repaired OS. His entering visual acuities were NLP OD and 20/400 OS. Upon biomicroscopic evaluation OD, there was evidence of a hypermature cataract with iris neovascularization and neovascularization coursing over and within the anterior capsule of the lens.
  
  
  CONCLUSIONS
  Intralenticular neovascularization is a rarely reported ocular complication. We present a patient with uncontrolled diabetes resulting in proliferative diabetic retinopathy, extreme ocular ischemia, and consequent intralenticular neovascularization.
authors.affiliation: Nova Southeastern University, College of Optometry, 3301 College Avenue, Fort Lauderdale, Florida, USA. pravina@nova.edu
authors.forename: Pravina
authors.initials: P
authors.lastname: Patel
authors.forename: Julie
authors.initials: J
authors.lastname: Rodman
mesh_terms: D002386:Cataract / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000150:complications* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007908:Lens, Crystalline / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D014792:Visual Acuity