title: Hypoglycaemic and hypolipidaemic activities of sesamin from sesame meal and its ability to ameliorate insulin resistance in KK-Ay mice.
abstract: BACKGROUND
  The ability of sesamin from sesame meal to ameliorate insulin resistance in KK-Ay mice (an animal model of type 2 diabetes) was evaluated.
  
  
  RESULTS
  Treatment with sesamin (100 or 50 mg kg(-1)) significantly decreased the level of fasting plasma glucose, glycosylated serum protein, serum insulin, triglycerides, cholesterol, free fatty acid and malondialdehyde content of livers. Treatment with sesamin significantly increased the content of hepatic glycogen, reduced glutathione and the activity of superoxide dismutase and glutathione peroxidase. Moreover, the insulin-binding capacity to liver crude plasma membranes increased and histopathological changes of the pancreas were ameliorated in the treatment group.
  
  
  CONCLUSIONS
  Sesamin has hypoglycaemic, hypolipidaemic and the ability to ameliorate insulin resistance in KK-Ay mice, which might be related to its effect on insulin receptors, and thus increases insulin sensitivity.
authors.affiliation: School of Biology and Food Engineering, Hefei University of Technology, Hefei, 230009, China. leihong56@163.com
authors.forename: Lei
authors.initials: L
authors.lastname: Hong
authors.forename: Wang
authors.initials: W
authors.lastname: Yi
authors.forename: Cai
authors.initials: C
authors.lastname: Liangliang
authors.forename: Han
authors.initials: H
authors.lastname: Juncheng
authors.forename: Wang
authors.initials: W
authors.lastname: Qin
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xiaoxiang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004149:Dioxoles / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005978:Glutathione; D005979:Glutathione Peroxidase; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D007333:Insulin Resistance; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D051379:Mice; D008810:Mice, Inbred C57BL; D031685:Sesamum / Q000737:chemistry*; D013482:Superoxide Dismutase
chemical_list: D001786:Blood Glucose; D004149:Dioxoles; D007004:Hypoglycemic Agents; D017705:Lignans; D008055:Lipids; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; C054125:sesamin