title: [New photosensitiser 5-ALA-GNPs for photodynamic therapy and its spectral analysis].
abstract: A novel strategy by means of poly diallyl dimethylammonium chloride (PDDA) was used to make highly mono-dispersed positively charged gold nanoparticles, and 5-ALA was immobilized onto the gold nanoparticles through electrostatic interaction. The conjugation of 5-aminolevulinic acid (5-ALA) and gold nanopartilces were characterized by the integrated tools of resonance Rayleigh scattering (RRS), UV-Vis absorption spectra, transmission electron microscopy (TEM) and laser light scattering. The results demonstrated that 5-ALA can be attached onto positively charged gold nanoparticles. This new photosensitizer is significant for enhancing PDT efficacy clinically.
authors.affiliation: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. zsycp@mail.xjtu.edu.cn
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Yao
authors.forename: Si-Jia
authors.initials: SJ
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Han
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.forename: Wei-Hui
authors.initials: WH
authors.lastname: Zeng
authors.forename: Zhen-Xi
authors.initials: ZX
authors.lastname: Zhang
mesh_terms: D000622:Aminolevulinic Acid / Q000737:chemistry*; D006046:Gold; D008027:Light; D053768:Metal Nanoparticles; D046529:Microscopy, Electron, Transmission; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D017319:Photosensitizing Agents; D006046:Gold; D000622:Aminolevulinic Acid