title: Removal of valproic acid by plasmapheresis in a patient treated for multiple sclerosis.
abstract: We present a case of a patient with multiple sclerosis who was treated with plasmapheresis and valproic acid. We used therapeutic drug monitoring to determine whether plasma concentrations of valproic acid were kept within the therapeutic window and to determine the amount of valproic acid that was removed by plasmapheresis.
authors.affiliation: Department of Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. d.bastiaans@akf.umcn.nl
authors.forename: D E T
authors.initials: DE
authors.lastname: Bastiaans
authors.forename: I W M
authors.initials: IW
authors.lastname: van Uden
authors.forename: R A
authors.initials: RA
authors.lastname: Ruiterkamp
authors.forename: B A
authors.initials: BA
authors.lastname: de Jong
mesh_terms: D000927:Anticonvulsants / Q000097:blood / Q000627:therapeutic use; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000188:drug therapy / Q000628:therapy*; D010956:Plasmapheresis / Q000379:methods*; D014635:Valproic Acid / Q000097:blood* / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid