title: Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China.
abstract: In this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.
authors.affiliation: Faculty of Public Health, Medical College of Xi'an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry of Education, Key Laboratory of Trace elements and Endemic Diseases of Ministry of Health, Xi'an 710061, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Li
authors.forename: Weizhuo
authors.initials: W
authors.lastname: Wang
authors.forename: Xiong
authors.initials: X
authors.lastname: Guo
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Weijuan
authors.initials: W
authors.lastname: Ma
authors.forename: Yingang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Youfen
authors.initials: Y
authors.lastname: Li
authors.forename: Yidong
authors.initials: Y
authors.lastname: Bai
authors.forename: Mikko J
authors.initials: MJ
authors.lastname: Lammi
mesh_terms: D000328:Adult; D017209:Apoptosis; D002356:Cartilage / Q000503:physiopathology*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D019353:Endemic Diseases; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D057767:Kashin-Beck Disease / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D010085:Oxidative Phosphorylation