title: [Perspective of creation of drugs on basis of opioids increasing cardiac tolerance to pathogenic impact of ischemia reperfusion].
abstract: It was established that delta- and kappa1-opioid receptor (OR) stimulation both in vivo and in vitro promotes a decrease of infarct size/area at risk (IS/AAR) ratio during ischemia and reperfusion of heart. mu-OR activation increases a tolerance of isolated perfused heart to impact of ischemia and reperfusion but has no effect on IS/AAR index in vivo. The ORL1-receptor agonist nociceptin does not exert IS/AAR ratio in vivo. Delta- and kappa1-OR stimulation prevents cardiomyocyte apoptosis during ischemia and reperfusion of heart. The delta- and kappa1-OR agonists mimic infarct-reducing effect of postconditioning. The OR inhibition does not impact IS/AAR index both in vivo and in vitro. The delta1-, delta2- and kappa1-OR agonists are the most perspective group of opioids for creation of drugs increasing cardiac tolerance to pathogenic impact of ischemia and reperfusion.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Lishmanov
authors.forename: J P
authors.initials: JP
authors.lastname: Headrick
authors.forename: J -M
authors.initials: J-
authors.lastname: Pei
authors.forename: L
authors.initials: L
authors.lastname: Hanus
authors.forename: A V
authors.initials: AV
authors.lastname: Krylatov
authors.forename: N V
authors.initials: NV
authors.lastname: Naryzhnaia
mesh_terms: D000701:Analgesics, Opioid / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D015195:Drug Design; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism; D011957:Receptors, Opioid / Q000819:agonists* / Q000378:metabolism
chemical_list: D000701:Analgesics, Opioid; D011957:Receptors, Opioid