title: [Mechanically gated cardiac ion channels and their regulation by cytokines].
abstract: The publication presents discussion of the modern vision of mechanisms of mechanoelectric feedback in heart as well as most recent findings regarding possible regulation of cardiomyocyte mechanically gated ion channels by endogenous compounds of immune origin--cytokines. Special attention is devoted to description of cytokine action on cardiac cells, in particular to nitrogen oxide effects on ionic currents, which contribute to generation of the action potential of the cardiomyocyte. We hypothesize that cytokines can potentially trigger such mechano-dependent cardiac pathologies as arrhythmias and fibrillation.
authors.forename: A G
authors.initials: AG
authors.lastname: Kamkin
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Makarenko
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D001145:Arrhythmias, Cardiac / Q000378:metabolism / Q000503:physiopathology; D001281:Atrial Fibrillation / Q000378:metabolism / Q000503:physiopathology; D054849:Cardiac Electrophysiology; D016207:Cytokines / Q000378:metabolism / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects*; D007473:Ion Channels / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D040542:Mechanotransduction, Cellular; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism / Q000494:pharmacology
chemical_list: D016207:Cytokines; D007473:Ion Channels; D009569:Nitric Oxide