title: Expression of girdin in human colorectal cancer and its association with tumor progression.
abstract: BACKGROUND
  Girdin is crucial for cellular motility in cancer cell lines and for metastasis in a mouse model. Its expression has been demonstrated in a range of cancers by a few studies and was a prognostic factor in a subset of patients.
  
  
  OBJECTIVE
  The aim of this study was to investigate the relationship of Girdin expression to clinicopathologic factors in terms of the progression of colorectal cancers and patient survival.
  
  
  METHODS
  This study is a retrospective review of immunohistochemical and clinicopathologic data.
  
  
  METHODS
  This study was conducted at a tertiary care hospital/referral center in South Korea.
  
  
  METHODS
  Tissue microarrays were made from surgical biopsies of 298 patients with colorectal cancer diagnosed between November 1996 and August 2007. Patients were included in the study if their survival time was known and if well-preserved surgical biopsy specimens were available.
  
  
  METHODS
  The primary outcomes measured were Girdin expression and its association in tumor progression and patient survival.
  
  
  RESULTS
  Positive staining for Girdin was observed in samples from 66 of 242 patients (27.3%). Expression of Girdin was significantly associated with tumor-node-metastasis stage (p = 0.036), liver metastasis (p = 0.025), and metastases involving the liver and other organs (p = 0.009). However, Girdin expression did not correlate significantly with the overall survival of patients and was not a significant negative prognostic factor for survival by univariate or multivariate analyses.
  
  
  CONCLUSIONS
  The number of investigated patients and the number of cases with positive staining for Girdin were rather small for the multivariate analysis. The inclusion time frame is long and includes other surgical and medical improvements, which influence a patient's survival.
  
  
  CONCLUSIONS
  The expression of Girdin is related to tumor metastasis but not to survival in human colorectal cancers.
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea.
authors.forename: Byoung Yeon
authors.initials: BY
authors.lastname: Jun
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Chan Kwon
authors.initials: CK
authors.lastname: Jung
authors.forename: Yu Kyung
authors.initials: YK
authors.lastname: Cho
authors.forename: In Seok
authors.initials: IS
authors.lastname: Lee
authors.forename: Myung-Gyu
authors.initials: MG
authors.lastname: Choi
authors.forename: Kyu Yong
authors.initials: KY
authors.lastname: Choi
authors.forename: Seong Taek
authors.initials: ST
authors.lastname: Oh
mesh_terms: D000368:Aged; D001706:Biopsy; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008501:Medical Records, Problem-Oriented; D008840:Microfilament Proteins / Q000378:metabolism*; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D040081:Protein Array Analysis; D015203:Reproducibility of Results; D056910:Republic of Korea; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D033921:Vesicular Transport Proteins / Q000378:metabolism*
chemical_list: C502451:CCDC88A protein, human; D008840:Microfilament Proteins; D033921:Vesicular Transport Proteins