title: Viewpoint: the ENIGMAS trial - when should we treat patients with moderate aortic stenosis?
abstract: Aortic stenosis (AS) is the most frequent valvular heart disease encountered in our daily practice. Although there are clear guidelines for severe AS management, cardiologists often have few treatment options for patients with moderate AS; however, there is higher mortality in this patient subgroup versus an age-matched population. The authors reviewed all of the studies on moderate AS, summarized the factors that increase disease progression and discussed an ideal trial design to prospectively evaluate AS progression factors using modern cardiology tools such as strain and magnetic resonance imaging.
authors.affiliation: Cardiology Department, "Bagdasar Arseni" Emergency Hospital, Bucharest, Romania. alexandru_mischie@yahoo.com
authors.forename: Alexandru Nicolae
authors.initials: AN
authors.lastname: Mischie
authors.forename: Catalina Liliana
authors.initials: CL
authors.lastname: Andrei
authors.forename: Crina
authors.initials: C
authors.lastname: Sinescu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery*; D006328:Cardiac Catheterization / Q000379:methods; D002309:Cardiology / Q000592:standards / Q000639:trends; D002423:Cause of Death; D018450:Disease Progression; D015150:Echocardiography, Doppler / Q000379:methods; D019317:Evidence-Based Medicine; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate; D016896:Treatment Outcome