title: [Hematopoietic cells raising with plerixafor in non-Hodgkin lymphoma].
abstract: BACKGROUND
  bone marrow autologous transplantation (BMAT) has proven benefits in patients treated for non-Hodgkin's lymphoma (NHL). Plerixafor is an inhibitor of CXCR4 receptor. The aim was to report the raise of hematopoietic cells with plerixafor in patients with NHL.
  
  
  METHODS
  patient 1 with follicular NHL, GI, intermediate FLIPI, CD20+, CD45+, BCL-2+, who reached complete response after three chemotherapy regimes. Mobilization failed after use of filgrastim (G-CSF) alone and G-CSF + cyclophosphamide. A new attempt was made with G-CSF + plerixafor (G-CSF, 10 μg/kg for 7 days + plerixafor, 240 μg/kg in days 4 to 7). Patient 2 with follicular NHL and CD20+ reached complete remission with MINE after therapeutic failure with other regimes, but develops severe marrow toxicity. Mobilization was supported with G-CSF 10 μg/kg/d + plerixafor in days 4 and 5. In case one, proper cell counts where obtained after three aphaeresis. In the second case, two harvests add of 2.7 × 106/kg were obtained.
  
  
  CONCLUSIONS
  plerixafor raised the hematopoietic stem cells in peripheral blood and improves mobilization of proper cell population.
authors.affiliation: Servicio de Hematología, Hospital de Especialidades, Puebla, Puebla Instituto Mexicano del Seguro Social, Mexico. dra_uendy@yahoo.com.mx
authors.forename: Uendy
authors.initials: U
authors.lastname: Pérez-Lozano
authors.forename: Francisco
authors.initials: F
authors.lastname: Tripp-Villanueva
authors.forename: Aline
authors.initials: A
authors.lastname: Ramírez-Alvarado
authors.forename: Jorge
authors.initials: J
authors.lastname: Vela-Ojeda
authors.forename: Alejandro
authors.initials: A
authors.lastname: Limón-Flores
authors.forename: José Luis
authors.initials: JL
authors.lastname: Kramis-Cerezo
mesh_terms: D000328:Adult; D001596:Benzylamines; D000080027:Cyclams; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male
chemical_list: D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; C088327:plerixafor