title: Co-administration of prostaglandin E1 with somatostatin attenuates acute             liver damage after massive hepatectomy in rats via inhibition of inflammatory             responses, apoptosis and endoplasmic reticulum stress.
abstract: Acute liver damage is considered to be the major cause of mortality after             massive hepatectomy. Prostaglandin E1 (PGE1) and somatostatin (SST) have been             shown to protect against hepatic injury of rats after partial hepatectomy. However,             the precise mechanisms remain largely unknown. In this study, we examined the             effects of PGE1, SST and the combination of these two drugs on acute liver damage             of rats after 90% hepatectomy. We found that animal survival was improved when             pretreated with PGE1 and SST. Portal venous pressure (PVP), serum alanine aminotransferase             (ALT) and aspartate aminotransaminase (AST), tumor necrosis factor-α (TNF-α) and             interleukin-6 (IL-6) were all reduced after administration of PGE1 and SST. In             addition, apoptosis was inhibited via upregulation of Bcl-2 and downregulation             of Bax and caspase-3 in drug treatment groups. Furthermore, pretreatment with             PGE1 and SST alleviated endoplasmic reticulum (ER) stress by induction of heat             shock protein 70 (HSP70) and glucose-regulated protein 78 (GRP78), but suppression             of transcription factor C/EBP homologous protein (CHOP). Our data suggest that             administration of PGE1 and SST, particularly in combination, may prevent acute             liver damage of rats after massive hepatectomy by inhibiting inflammatory responses,             apoptosis and ER stress.
authors.affiliation: Department of Hepato-Biliary-Splenic Surgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, P.R. China. chaoliu_dai@163.com
authors.forename: Changjun
authors.initials: C
authors.lastname: Jia
authors.forename: Chaoliu
authors.initials: C
authors.lastname: Dai
authors.forename: Xianmin
authors.initials: X
authors.lastname: Bu
authors.forename: Songlin
authors.initials: S
authors.lastname: Peng
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Xu
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D016207:Cytokines / Q000032:analysis; D019610:Cytoprotection / Q000187:drug effects; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects; D006498:Hepatectomy / Q000379:methods; D006728:Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects* / Q000293:injuries* / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000008:administration & dosage / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D016207:Cytokines; D006728:Hormones; D014665:Vasodilator Agents; D013004:Somatostatin; D000527:Alprostadil