title: Association of G/A polymorphism, rs266882, in AREI region of the prostate-specific antigen gene with prostate cancer risk and clinicopathological features.
abstract: OBJECTIVE
  To determine the association of prostate-specific antigen (PSA) 158A/G polymorphism with clinicopathologic characteristics of the disease and prostate cancer (PCa) risk.
  
  
  METHODS
  Two hundred and six subjects, including 95 patients with PCa and 111 subjects with benign prostatic hyperplasia (BPH), were recruited in this study. Genotyping was performed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism method.
  
  
  RESULTS
  Presence of GG genotype significantly increased the risk of PCa more than 2-fold compared to AG genotype (adjusted odds ratio = 2.4; P = .03). The percentages of G alleles of polymorphisms in patients with PCa were more than that in ones with BPH (odds ratio = 1.2; P = .7).
  
  
  CONCLUSIONS
  The GG genotype of PSA 158A/G polymorphism is a predisposing factor for PCa. But no association was observed between alleles and grade, stage, or age of diagnosis. Similarly, the rs266882 polymorphism was not associated with PSA plasma levels.
authors.affiliation: Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Samzadeh
authors.forename: Mandana
authors.initials: M
authors.lastname: Hasanzad
authors.forename: Seyed Hamid
authors.initials: SH
authors.lastname: Jamaldini
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Haghdoost
authors.forename: Mahdi
authors.initials: M
authors.lastname: Afshari
authors.forename: Seyed Amir Mohsen
authors.initials: SA
authors.lastname: Ziaee
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017430:Prostate-Specific Antigen / Q000235:genetics*; D011470:Prostatic Hyperplasia / Q000235:genetics* / Q000601:surgery; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery
chemical_list: D017430:Prostate-Specific Antigen