title: Role of cadherin-11 in synovial joint formation and rheumatoid arthritis pathology.
abstract: Cadherin-11 is a classic cadherin adhesion molecule that mediates homophilic cell-to-cell adhesion. Cadherin-11 is involved in the function of embryonic development, tissue morphogenesis, tumor invasion and metastasis, and signal transduction. This review summarizes the function of cadherin-11 in synovial joint formation and rheumatoid arthritis (RA), including its relative function with bone and cartilage development and growth plate, synovial, and tendon formation. The role of cadherin-11 in RA is also discussed, both in fibroblasts inflammation and fibroblast-like synoviocyte (FLSs) migration and invasion. The potential of anti-cadherin-11 therapy for RA is introduced in comparison with the other current RA therapies.
authors.affiliation: Department of Anatomy, Tissue Engineering Research Center of Chongqing, The Third Military Medical University, Gaotanyan Street No. 30, Chongqing, 400038, China.
authors.forename: Ce
authors.initials: C
authors.lastname: Dou
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Yan
authors.forename: Shiwu
authors.initials: S
authors.lastname: Dong
mesh_terms: D001172:Arthritis, Rheumatoid / Q000378:metabolism* / Q000473:pathology; D015820:Cadherins / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology; D020219:Chondrogenesis / Q000502:physiology; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism* / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology
chemical_list: D015820:Cadherins; C086960:osteoblast cadherin