title: Mortality trends and prediction of HPV-related cancers in Brazil.
abstract: Estimation of the size of a cancer group, either through number of cases or extrapolation of past observed trends, is indispensable to the planning of effective assistance measures. The aim of this study was to analyze the mortality trends of human papillomavirus-related cancers in Brazil by sex, in the period 1996-2010, and make predictions until the year 2025. All deaths registered as being a result of cervical cancer (ICD-10 code: C53), as well as those caused by vulvar and vaginal (C51 and C52), anal (C21), penile (C60), and oropharyngeal (C02, C09, C10) cancers, were registered. Adjusted rate calculations for each year were used to study the trends through the regression program 'Joinpoint'. Predictions were made using the Nordpred program, utilizing the age-period-cohort model. When analyzing separately by location, it was observed that penile and anal cancers in men presented an increasing trend for the entire period with a statistically significant annual percentage change of 4% for anal cancer and 1.4% for penile cancer. Predictions indicate a reduction in the risk of death due to oropharyngeal cancer in men and cervical, vulvar, and vaginal cancers in women. It was observed that the increase in the number of deaths occurs mainly because of population changes (size and age structure). In terms of risk, an increase is predicted for anal and penile cancers in men and consequently an increase in mortality rates is observed for these types of cancers, unlike what is expected for human papillomavirus-related cancers in women.
authors.affiliation: Department of Public Health, Federal University of Rio Grande do Norte, Natal, RN, Brazil. dysouz@yahoo.com.br
authors.forename: Dyego L B
authors.initials: DL
authors.lastname: de Souza
authors.forename: Maria Paula
authors.initials: MP
authors.lastname: Curado
authors.forename: María Milagros
authors.initials: MM
authors.lastname: Bernal
authors.forename: Javier
authors.initials: J
authors.lastname: Jerez-Roig
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
mesh_terms: D001005:Anus Neoplasms / Q000209:etiology / Q000401:mortality; D001938:Brazil / Q000453:epidemiology; D005260:Female; D006801:Humans; D007114:Immunization; D008297:Male; D009959:Oropharyngeal Neoplasms / Q000209:etiology / Q000401:mortality; D030361:Papillomavirus Infections / Q000150:complications*; D053918:Papillomavirus Vaccines / Q000276:immunology; D010412:Penile Neoplasms / Q000209:etiology / Q000401:mortality; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000401:mortality; D014625:Vaginal Neoplasms / Q000209:etiology / Q000401:mortality
chemical_list: D053918:Papillomavirus Vaccines