title: Bioactive cis-stilbenoids from the tubers of Scirpus yagara.
abstract: Two new cis-stilbenoids, sciryagarol I (1) and II (2) were isolated from the EtOAc extract of the tubers of Scirpus yagara, together with four known compounds. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature information. The compounds 3, 4 and 6 were isolated for the first time from this genus. Some compounds were tested for their cytotoxicity against human tumor cell lines and antimicrobial activity. Compounds 1-4 showed significant cytotoxicity against the Hela cell lines with IC(50) values ranging from 7.21 to 61.21μM. 1 and 2 exhibited some antimicrobial activity against Staphylococcus aureus and Candida albicans with uniform MICs of 79.3μl/ml for 2, and 152μl/ml for 1, respectively.
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China. liangqiaoli2008@163.com
authors.forename: Qiao-Li
authors.initials: QL
authors.lastname: Liang
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Lei
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Cui
authors.forename: Nuo-Shu
authors.initials: NS
authors.lastname: Zou
authors.forename: Jin-Ao
authors.initials: JA
authors.lastname: Duan
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D029785:Cyperaceae / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D035281:Plant Tubers / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes