title: Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis.
abstract: Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to bone metastasis that involves osteoblasts, osteoclasts, and tumor cells.
authors.affiliation: Department of Medicine; Division of Oncology; Washington University School of Medicine; St. Louis, MO USA.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Hurchla
authors.forename: Katherine N
authors.initials: KN
authors.lastname: Weilbaecher