title: Elevated oral and systemic levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in periodontitis.
abstract: The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell-surface receptor of the immunoglobulin superfamily, involved in the propagation of the inflammatory response to bacterial challenge. Soluble (s)TREM-1 is released from the cell surface during the course of infection and is a useful inflammatory biomarker in the early diagnosis of systemic sepsis. The hypothesis of this study was that oral and systemic levels of sTREM-1 are elevated in periodontitis. Therefore, the aim was to investigate, by ELISA, the sTREM-1 concentrations in saliva and serum of individuals without periodontitis (control) and persons with chronic or generalized aggressive periodontitis. In saliva, sTREM-1 concentrations were higher in chronic and aggressive periodontitis than in the control group, by 3.3-fold and 5.6-fold, respectively. In serum, these differences were 1.7-fold and 2-fold, respectively. However, there were no significant differences between the two forms of periodontitis, neither in saliva nor in serum. Salivary and serum sTREM-1 levels positively correlated with full-mouth clinical periodontal parameters. In conclusion, the increased oral and systemic levels of sTREM-1 in periodontitis denote a value for this molecule as a biomarker for the disease and may also have implications in the association between periodontal infections and systemic inflammatory response.
authors.affiliation: Oral Translational Research, Institute of Oral Biology, Center of Dental Medicine, University of Zürich, Switzerland. nagihan.bostanci@zzm.uzh.ch
authors.forename: N
authors.initials: N
authors.lastname: Bostanci
authors.forename: V Ö
authors.initials: VÖ
authors.lastname: Oztürk
authors.forename: G
authors.initials: G
authors.lastname: Emingil
authors.forename: G N
authors.initials: GN
authors.lastname: Belibasakis
mesh_terms: D010520:Aggressive Periodontitis / Q000097:blood / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood / Q000378:metabolism*; D003774:Dental Plaque Index; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis / Q000097:blood; D053583:Interleukin-1beta / Q000032:analysis / Q000097:blood; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000097:blood; D022423:Myeloid Cells / Q000378:metabolism*; D017622:Periodontal Attachment Loss / Q000097:blood / Q000473:pathology; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000473:pathology; D010519:Periodontium / Q000378:metabolism; D011971:Receptors, Immunologic / Q000032:analysis* / Q000097:blood; D012463:Saliva / Q000737:chemistry*; D012907:Smoking; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1