title: [Clinical characteristics of non-alcoholic steatohepatitis (NASH) patients who progressed from F3 stage fibrosis to cirrhotic NASH].
abstract: The present study investigated the clinical characteristics of non-alcoholic steatohepatitis (NASH) patients who progressed from stage 3, zone 3 bridging fibrosis (F3 stage NASH) to cirrhosis. Of 95 NASH patients with repeated liver biopsies during a period of 4.6 years, 6 patients progressed to cirrhosis. The initial liver biopsies of these 6 patients were diagnosed as F3 stage NASH. Simple clinical variables and non-invasive biological tests were evaluated in 33 cases of F3 stage NASH. Increases in body mass index and fluctuations in transaminase levels, as well as the evaluation of homeostatic model assessment-insulin resistance, ferritin, and hyaluronic acid in F3 stage NASH patients may prove useful in identifying individuals at risk of progression to cirrhosis.
authors.affiliation: Department of General Internal Medicine 2, KawKawasaki Medical School, Japan. m.kawanaka@med.kawasaki-m.ac.jp
authors.forename: Miwa
authors.initials: M
authors.lastname: Kawanaka
authors.forename: Takahito
authors.initials: T
authors.lastname: Oka
authors.forename: Noriyo
authors.initials: N
authors.lastname: Urata
authors.forename: Tomonari
authors.initials: T
authors.lastname: Kimura
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Goto
authors.forename: Ryumei
authors.initials: R
authors.lastname: Yamato
authors.forename: Ken
authors.initials: K
authors.lastname: Nishino
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Suehiro
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kawamoto
authors.forename: Gotaro
authors.initials: G
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D018450:Disease Progression; D005234:Fatty Liver / Q000473:pathology*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged