title: β-Amyloid in Lewy body disease is related to Alzheimer's disease-like atrophy.
abstract: The aim of this study was to investigate whether amyloid deposition is associated with Alzheimer's disease (AD)-like cortical atrophy in Lewy body (LB) disease (LBD). Participants included 15 LBD with dementia patients (8 with dementia with Lewy bodies [DLB] and 7 with Parkinson's disease [PD] with dementia [PDD]), 13 AD patients, and 17 healthy controls. Age, gender, and Mini-Mental State Examination scores were matched between patient groups. All subjects underwent PET scans with [(11)C]Pittsburgh Compound B to measure brain amyloid deposition as well as three-dimensional T1-weighted MRI. Gray-matter volumes (GMVs) were estimated by voxel-based morphometry. Volumes-of-interest analyses were also performed. Forty percent of the 15 DLB/PDD patients were amyloid positive, whereas all AD patients and none of the healthy controls were amyloid positive. Amyloid-positive DLB/PDD and AD patients showed very similar patterns of cortical atrophy in the parahippocampal area and lateral temporal and parietal cortices, with 95.2% of cortical atrophy distribution being overlapped. In contrast, amyloid-negative DLB/PDD patients had no significant cortical atrophy. Compared to healthy controls, parahippocampal GMVs were reduced by 26% in both the amyloid-positive DLB/PDD and AD groups and by 10% in the amyloid-negative DLB/PDD group. The results suggest that amyloid deposition is associated with AD-like atrophy in DLB/PDD patients. Early intervention against amyloid may prevent or delay AD-like atrophy in DLB/PDD patients with amyloid deposition.
authors.affiliation: Molecular Imaging Center, Molecular Neuroimaging Program, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shimada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shinotoh
authors.forename: Shigeki
authors.initials: S
authors.lastname: Hirano
authors.forename: Michie
authors.initials: M
authors.lastname: Miyoshi
authors.forename: Koichi
authors.initials: K
authors.lastname: Sato
authors.forename: Noriko
authors.initials: N
authors.lastname: Tanaka
authors.forename: Tsuneyoshi
authors.initials: T
authors.lastname: Ota
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fukushi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Irie
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.forename: Makoto
authors.initials: M
authors.lastname: Higuchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Suhara
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000378:metabolism*; D000704:Analysis of Variance; D000814:Aniline Compounds; D001284:Atrophy; D052160:Benzothiazoles; D003704:Dementia / Q000378:metabolism / Q000473:pathology / Q000523:psychology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020961:Lewy Body Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology / Q000523:psychology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D052160:Benzothiazoles; D019275:Radiopharmaceuticals; D013844:Thiazoles