title: [Efficacy of 153Sm-EDTMP in the treatment of prostate cancer with bone metastasis].
abstract: OBJECTIVE
  To investigate the efficacy of 153Sm-EDTMP in the treatment of bone metastasis of prostate cancer (PCa) by comparison with zoledronic acid.
  
  
  METHODS
  We assigned 55 PCa patients with bone metastasis to receive 153Sm-EDTMP (n = 31) and zoledronic acid (n = 24), the former injected intravenously at the dose of 37.0 MBq/kg body weight, and the latter administered by slow intravenous drip at 4 mg in 100 ml of 0.9% sodium chloride. We performed 99mTc-MDP bone scan before and 1 -2 months after the treatment.
  
  
  RESULTS
  The rate of pain relief was 83.9% in the 153Sm-EDTMP group and 58.3% in the zoledronic acid group (P = 0.035), and that of bone metabolism change was 64.5% in the former and 33.3% in the latter (P = 0.022).
  
  
  CONCLUSIONS
  153Sm-EDTMP is an ideal agent for the treatment of prostate cancer with bone metastasis.
authors.affiliation: Department of Nuclear Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710004, China. fengjuanyi1994@126.com
authors.forename: Juan-Yi
authors.initials: JY
authors.lastname: Feng
authors.forename: Chuang-Qi
authors.initials: CQ
authors.lastname: Wu
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: She-Jiao
authors.initials: SJ
authors.lastname: Wang
authors.forename: Xiang-Hong
authors.initials: XH
authors.lastname: Zheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000188:drug therapy; D009942:Organometallic Compounds / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D000077211:Zoledronic Acid; C061972:samarium Sm-153 lexidronam