title: CAR&#39;s made it to the pancreas.
abstract: Despite intensive treatment, pancreatic adenocarcinoma still has the worst prognosis among all malignancies. Using clinically relevant models, we demonstrated the therapeutic efficacy of adoptively transferred T cells engineered with a carcinoembryonic antigen (CEA)- and ERBB2-specific chimeric antigen receptor against pancreatic carcinoma. Targeting CD24, a putative cancer stem cell antigen expressed by a minority of carcinoma cells, was likewise effective.
authors.affiliation: Center for Molecular Medicine Cologne (CMMC); Department I of Internal Medicine; University Hospital Cologne; Cologne, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Chmielewski
authors.forename: Amit
authors.initials: A
authors.lastname: Maliar
authors.forename: Zelig
authors.initials: Z
authors.lastname: Eshhar
authors.forename: Hinrich
authors.initials: H
authors.lastname: Abken