title: [Molecular and genetic background of sudden cardiac death].
abstract: Despite recent findings on the functional, structural and genetic background of sudden cardiac death, the incidence is still relatively high in the entire population. A thorough knowledge on susceptibility, as well as pathophysiology behind the development of malignant arrhythmias will help us to identify individuals at risk and prevent sudden cardiac death. This article presents a review of the current literature on the role of altered intracellular Ca2+ handling, acute myocardial ischaemia, cardiac autonomic innervation, renin-angiotensin-aldosterone system, monogenic and complex heritability in the pathogenesis of sudden cardiac death.
authors.affiliation: Miskolci Semmelweis Ignác Egészségügyi Központ és Egyetemi Oktatókórház Nonprofit Kft. Belgyógyászati Intézet, Kardiológiai Osztály Miskolc. sjozs74@hotmail.com
authors.forename: József
authors.initials: J
authors.lastname: Simkó
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szabó
authors.forename: Kitti
authors.initials: K
authors.lastname: Barta
authors.forename: Dóra
authors.initials: D
authors.lastname: Ujvárosi
authors.forename: Péter
authors.initials: P
authors.lastname: Nánási
authors.forename: István
authors.initials: I
authors.lastname: Lőrincz
mesh_terms: D000208:Acute Disease; D001145:Arrhythmias, Cardiac / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology*; D053840:Brugada Syndrome / Q000150:complications; D015220:Calcium Channels / Q000378:metabolism*; D009202:Cardiomyopathies / Q000150:complications; D016757:Death, Sudden, Cardiac / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D004198:Disease Susceptibility; D020022:Genetic Predisposition to Disease; D006321:Heart / Q000294:innervation; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008133:Long QT Syndrome / Q000150:complications; D017202:Myocardial Ischemia / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System
chemical_list: D015220:Calcium Channels