title: Role of p63 in differentiating morphologically ambiguous lesions of prostate.
abstract: OBJECTIVE
  To observe the role of p63 staining in evaluation of morphologically ambiguous lesions of prostate.
  
  
  METHODS
  Descriptive (case series) study.
  
  
  METHODS
  Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from March to September 2010.
  
  
  METHODS
  p63 immunohistochemistry staining was performed on 30 cases diagnosed as morphologically ambiguous lesions of prostate by histopathologist. Patient's name, age, histology numbers, morphological features, expression of p63 and histopathological diagnosis were recorded and described as frequency percentages.
  
  
  RESULTS
  The prostatic adenocarcinomas were negative for p63 and benign lesions of prostate were positive for p63. Atypical lesions show positive staining in 77.7% and negative staining in 33.3% of cases.
  
  
  CONCLUSIONS
  p63 immunohistochemistry staining can be used as a reliable marker to distinguish between benign from malignant morphologically ambiguous lesions of prostate.
authors.affiliation: Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore.
authors.forename: Muhammad Kashif
authors.initials: MK
authors.lastname: Baig
authors.forename: Usman
authors.initials: U
authors.lastname: Hassan
authors.forename: Samina
authors.initials: S
authors.lastname: Mansoor
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D010154:Pakistan; D011467:Prostate / Q000378:metabolism / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000378:metabolism; D013194:Staining and Labeling
chemical_list: D014408:Biomarkers, Tumor; C081876:CKAP4 protein, human; D008565:Membrane Proteins