title: The novel anticoagulants: the surgeons' prospective.
abstract: Anticoagulants can complicate the approach to the management of patients undergoing operative interventions. We review new anticoagulants that have been introduced recently to the market or that are undergoing investigations for treatment of nonvalvular atrial fibrillation and venous thromboembolism prophylaxis: Dabigatran, rivaroxaban, apixiban, and edoxaban.
authors.affiliation: Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA. Shamoun.fadi@mayo.edu
authors.forename: Fadi E
authors.initials: FE
authors.lastname: Shamoun
authors.forename: Elvis N
authors.initials: EN
authors.lastname: Martin
authors.forename: Samuel R
authors.initials: SR
authors.lastname: Money
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology; D001281:Atrial Fibrillation / Q000188:drug therapy; D001562:Benzimidazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D016063:Blood Loss, Surgical; D002986:Clinical Trials as Topic; D000069604:Dabigatran; D006801:Humans; D009025:Morpholines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D011720:Pyrazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D011725:Pyridines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D011728:Pyridones / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D000069552:Rivaroxaban; D020521:Stroke / Q000517:prevention & control; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D013844:Thiazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D013876:Thiophenes / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D054556:Venous Thromboembolism / Q000517:prevention & control; D014859:Warfarin / Q000009:adverse effects; D015091:beta-Alanine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000925:Anticoagulants; D001562:Benzimidazoles; D009025:Morpholines; D011720:Pyrazoles; D011725:Pyridines; D011728:Pyridones; D013844:Thiazoles; D013876:Thiophenes; D015091:beta-Alanine; C522181:apixaban; D014859:Warfarin; D000069552:Rivaroxaban; D000069604:Dabigatran; C552171:edoxaban