title: Synthesis of N-acylcarbazoles through palladium-catalyzed aryne annulation of 2-haloacetanilides.
abstract: N-Acylcarbazoles have been synthesized in moderate to good yields by the annulation of in situ generated arynes with 2-haloacetanilides in the presence of a palladium catalyst and CsF. Both C-C and C-N bonds are formed simultaneously, and a variety of functional groups are tolerated in this reaction.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Chun
authors.initials: C
authors.lastname: Lu
authors.forename: Nataliya A
authors.initials: NA
authors.lastname: Markina
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
mesh_terms: D000083:Acetanilides / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D013379:Substrate Specificity
chemical_list: D000083:Acetanilides; D002227:Carbazoles; D010165:Palladium; D001554:Benzene; C508827:acetanilide