title: Aclidinium bromide for the treatment of chronic obstructive pulmonary disease.
abstract: Chronic obstructive pulmonary disease is characterized by poorly reversible airflow obstruction. Long-acting bronchodilators improve lung function and relieve dyspnea. Aclidinium bromide is a novel long-acting antimuscarinic bronchodilator; Phase III clinical trials have demonstrated that administration of this drug twice per day improves lung function, dyspnea and health-related quality of life. Aclidinium bromide is delivered using the Genuair(®) device, which is an easy to use multidose dry powder inhaler. Aclidinium bromide is rapidly metabolized in the plasma, so there is low systemic exposure that minimizes the anticholinergic side effects. This new long-acting bronchodilator provides effective bronchodilation with minimal side effects.
authors.affiliation: University of Manchester, Medicines Evaluation Unit, University Hospital of South Manchester Foundation Trust, Manchester, M23 9QZ, UK.
authors.forename: Vandana
authors.initials: V
authors.lastname: Gupta
authors.forename: Dave
authors.initials: D
authors.lastname: Singh
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D001993:Bronchodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D058995:Dry Powder Inhalers; D017079:Exercise Tolerance; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use; D018727:Muscarinic Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D011976:Receptors, Muscarinic / Q000378:metabolism; D012602:Scopolamine Derivatives / Q000627:therapeutic use; D015398:Signal Transduction; D000069447:Tiotropium Bromide; D014326:Tropanes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D001993:Bronchodilator Agents; D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D012602:Scopolamine Derivatives; D014326:Tropanes; D009241:Ipratropium; D000109:Acetylcholine; C542859:aclidinium bromide; D000069447:Tiotropium Bromide