title: An intravenous implantable glucose/dioxygen biofuel cell with modified flexible carbon fiber electrodes.
abstract: An intravenous implantable glucose/dioxygen hybrid enzyme-Pt micro-biofuel cell (BFC) was investigated. In this miniaturized BFC, a flexible carbon fiber (FCF) microelectrode modified with neutral red redox mediator and glucose oxidase was used as the bioanode, and an FCF modified with platinum nanoparticles stabilized on PAMAM-G4 dendrimer was used as the cathode. In vitro experiments conducted using the BFC in a phosphate buffer solution (50 mmol L(-1), pH = 7.2) and glucose (47 mmol L(-1)) showed high electrocatalytic performance with an open circuit voltage (OCV) of 400 mV, a maximum current density of 2700 μA cm(-2) at 0.0 V and a maximum output power of 200 μW cm(-2) at 250 mV. Under physiological conditions, glucose from rat blood is used as a fuel in anodic reactions and dissolved molecular oxygen is used as the oxidizing agent on the cathode. For in vivo experiments, the BFC was inserted into the jugular vein of a living rat (Rattus novergicus) using a catheter (internal diameter 0.5 mm). The power density of the implantable BFC was evaluated over a period of 24 h, and an OCV of 125 mV with a maximum power density of 95 μW cm(-2) was obtained at 80 mV.
authors.affiliation: Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo ndré, SP, Brazil.
authors.forename: Fernanda C P F
authors.initials: FC
authors.lastname: Sales
authors.forename: Rodrigo M
authors.initials: RM
authors.lastname: Iost
authors.forename: Marccus V A
authors.initials: MV
authors.lastname: Martins
authors.forename: Maria C
authors.initials: MC
authors.lastname: Almeida
authors.forename: Frank N
authors.initials: FN
authors.lastname: Crespilho
mesh_terms: D000818:Animals; D001674:Bioelectric Energy Sources; D002244:Carbon; D000077482:Carbon Fiber; D050091:Dendrimers / Q000737:chemistry; D004566:Electrodes; D004867:Equipment Design; D005947:Glucose / Q000737:chemistry*; D005949:Glucose Oxidase / Q000378:metabolism; D008297:Male; D053758:Nanoparticles / Q000737:chemistry; D009757:Nylons / Q000737:chemistry; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000077482:Carbon Fiber; D050091:Dendrimers; D009757:Nylons; C520550:PAMAM-G4; D002244:Carbon; D005949:Glucose Oxidase; D005947:Glucose; D010100:Oxygen