title: Snapshots: chromatin control of viral infection.
abstract: Like their cellular host counterparts, many invading viral pathogens must contend with, modulate, and utilize the host cell's chromatin machinery to promote efficient lytic infection or control persistent-latent states. While not intended to be comprehensive, this review represents a compilation of conceptual snapshots of the dynamic interplay of viruses with the chromatin environment. Contributions focus on chromatin dynamics during infection, viral circumvention of cellular chromatin repression, chromatin organization of large DNA viruses, tethering and persistence, viral interactions with cellular chromatin modulation machinery, and control of viral latency-reactivation cycles.
authors.affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Knipe
authors.forename: Paul M
authors.initials: PM
authors.lastname: Lieberman
authors.forename: Jae U
authors.initials: JU
authors.lastname: Jung
authors.forename: Alison A
authors.initials: AA
authors.lastname: McBride
authors.forename: Kevin V
authors.initials: KV
authors.lastname: Morris
authors.forename: Melanie
authors.initials: M
authors.lastname: Ott
authors.forename: David
authors.initials: D
authors.lastname: Margolis
authors.forename: Amelia
authors.initials: A
authors.lastname: Nieto
authors.forename: Michael
authors.initials: M
authors.lastname: Nevels
authors.forename: Robin J
authors.initials: RJ
authors.lastname: Parks
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Kristie
mesh_terms: D002843:Chromatin / Q000235:genetics* / Q000821:virology; D042002:Chromatin Assembly and Disassembly; D004267:DNA Viruses / Q000235:genetics* / Q000472:pathogenicity; D044127:Epigenesis, Genetic; D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D054884:Host-Pathogen Interactions; D006801:Humans; D012328:RNA Viruses / Q000235:genetics* / Q000472:pathogenicity; D014777:Virus Diseases / Q000235:genetics* / Q000378:metabolism / Q000821:virology; D017735:Virus Latency; D014779:Virus Replication
chemical_list: D002843:Chromatin