title: 18F-FDG PET/CT findings in a patient with isolated intracranial Rosai-Dorfman disease.
abstract: Rosai-Dorman disease (RDD) or sinus histiocytosis with massive lymphadenopathy is a rare histiocytic disorder first described in 1969. RDD involving the central nervous system is considered to be rare, with fewer than 120 cases reported in the literature. We present a 51-year-old woman with a history of panhypopituitarism, episodic memory disturbance, and a hypothalamic tumor. Stereotaxic hypothalamic lesion biopsy showed histiocytic proliferation positive for S100 protein and CD68, but negative for CD1a, typical for RDD. ¹⁸F-FDG PET/CT 4 months later demonstrated increased hypothalamic metabolic activity.
authors.affiliation: Department of Nuclear Medicine, Hôpital Edouard Herriot, Lyon, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Deshayes
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Le Berre
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Jouanneau
authors.forename: Alexandre
authors.initials: A
authors.lastname: Vasiljevic
authors.forename: Gérald
authors.initials: G
authors.lastname: Raverot
authors.forename: Pascal
authors.initials: P
authors.lastname: Seve
mesh_terms: D001706:Biopsy; D005260:Female; D019788:Fluorodeoxyglucose F18; D006644:Histiocytes / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D012886:Skull / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18