title: Association between polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer risk in a sample Iranian population.
abstract: OBJECTIVE
  Genetic and environmental factors are risk factors for breast cancer. Our aim was to investigate the associations between genetic polymorphism of GST genes (GSTM1, GSTT1 and GSTP1) and susceptibility to breast cancer in an Iranian population.
  
  
  METHODS
  This case-control study was carried out on 134 patients with breast cancer and 152 healthy, cancer-free women. GSTP1 polymorphism was determined using tetra-primer amplification refractory mutation system PCR assay and GSTM1 and GSTT1 were genotyped by a multiplex PCR.
  
  
  RESULTS
  We found that the GSTM1 null genotype is a risk factor for predisposition to breast cancer (odds ratio [OR] = 2.01; 95% CI = 1.78-3.45; p = 0.010). No significant difference was found between the groups regarding GSTT1 null genotype (p > 0.05). The GSTP1 Ile/Val and Val/Val genotypes were associated with breast cancer risk (OR = 3.29; 95% CI = 1.84-5.91; p < 0.0001 and OR = 20.68; 95% CI = 5.66-75.60; p < 0.0001, respectively).
  
  
  CONCLUSIONS
  In summary, GSTM1 and GSTP1, but not GSTT1 genetic polymorphisms are associated with increased risk of breast cancer in our population.
authors.affiliation: Cellular & Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. mhd.hashemi@gmail.com
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Eskandari-Nasab
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Fazaeli
authors.forename: Mohsen
authors.initials: M
authors.lastname: Taheri
authors.forename: Hamzeh
authors.initials: H
authors.lastname: Rezaei
authors.forename: Mohammadali
authors.initials: M
authors.lastname: Mashhadi
authors.forename: Farshid
authors.initials: F
authors.lastname: Arbabi
authors.forename: Mahmoud-Ali
authors.initials: MA
authors.lastname: Kaykhaei
authors.forename: Mehdi
authors.initials: M
authors.lastname: Jahantigh
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Bahari
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D051549:Glutathione S-Transferase pi / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007492:Iran; D008593:Menopause / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human