title: Extensive reduction of cell viability and enhanced matrix production in Pseudomonas aeruginosa PAO1 flow biofilms treated with a D-amino acid mixture.
abstract: Treatment of Pseudomonas aeruginosa PAO1 flow biofilms with a D-amino acid mixture caused significant reductions in cell biomass by 75% and cell viability by 71%. No biofilm disassembly occurred, and matrix production increased by 30%, thereby providing a thick protective cover for remaining viable or persister cells.
authors.affiliation: Department of Materials Science and Chemical Engineering, Shizuoka University, Hamamatsu, Japan.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Sanchez
authors.forename: Akio
authors.initials: A
authors.lastname: Tani
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Kimbara
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D018441:Biofilms / Q000187:drug effects*; D018533:Biomass; D005109:Extracellular Matrix / Q000378:metabolism*; D050296:Microbial Viability / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*
chemical_list: D000596:Amino Acids