title: Facile regioselective synthesis of novel bioactive thiazolyl-pyrazoline derivatives via a three-component reaction and their antimicrobial activity.
abstract: A series of novel 2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles have been prepared by a three-component cyclo-condensation of various chalcones, thiosemicarbazide and phenacyl bromide. The easy work-up of the products, rapid reaction, and mild conditions are notable features of this protocol. The reaction was efficiently catalyzed in one-pot by a few drops of HCl in EtOH under reflux conditions providing the title compounds in moderate to high yields. The antibacterial activity of the selected products was examined. Some products exhibit promising activities.
authors.affiliation: Department of Organic Chemistry, University of Guilan, PO Box 41335-1914, Rasht, Iran.
authors.forename: Bahman
authors.initials: B
authors.lastname: Sharifzadeh
authors.forename: Nosrat O
authors.initials: NO
authors.lastname: Mahmoodi
authors.forename: Manouchehr
authors.initials: M
authors.lastname: Mamaghani
authors.forename: Khalil
authors.initials: K
authors.lastname: Tabatabaeian
authors.forename: Alireza Salimi
authors.initials: AS
authors.lastname: Chirani
authors.forename: Iraj
authors.initials: I
authors.lastname: Nikokar
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002384:Catalysis; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D011720:Pyrazoles; D013844:Thiazoles