title: Patterning of microspheres and microbubbles in an acoustic tweezers.
abstract: We describe the construction of an ultrasonic device capable of micro-patterning a range of microscopic particles for bioengineering applications such as targeted drug delivery. The device is formed from seven ultrasonic transducers positioned around a heptagonal cavity. By exciting two or three transducers simultaneously, lines or hexagonal shapes can be formed with microspheres, emulsions and microbubbles. Furthermore, phase control of the transducers allows patterning at any desired position in a controlled manner. The paper discusses in detail direct positioning of functionalised microspheres, emulsions and microbubbles. With the advantages of miniaturization, rapid and simple fabrication, ultrasonic tweezers is a potentially useful tool in many biomedical applications.
authors.affiliation: School of Engineering, University of Glasgow, G12 8LT, Glasgow, UK. Anne.Bernassau@glasgow.ac.uk
authors.forename: A L
authors.initials: AL
authors.lastname: Bernassau
authors.forename: P G A
authors.initials: PG
authors.lastname: Macpherson
authors.forename: J
authors.initials: J
authors.lastname: Beeley
authors.forename: B W
authors.initials: BW
authors.lastname: Drinkwater
authors.forename: D R S
authors.initials: DR
authors.lastname: Cumming
mesh_terms: D004655:Emulsions / Q000737:chemistry* / Q000528:radiation effects*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D045423:Microbubbles; D008846:Micromanipulation / Q000295:instrumentation*; D054802:Molecular Imprinting / Q000295:instrumentation*; D052898:Optical Tweezers; D013010:Sonication / Q000295:instrumentation*
chemical_list: D004655:Emulsions