title: Functional dyspepsia: subtypes, risk factors, and overlap with irritable bowel syndrome in a population of african patients.
abstract: Background. Functional dyspepsia is the prototype functional gastrointestinal disorder. This study was designed to determine its prevalence, subtypes, and risk factors associated with the subtypes. Method. Patients with upper gastrointestinal symptoms who presented for endoscopy were administered a questionnaire containing the functional dyspepsia and irritable bowel syndrome modules of the Rome III diagnostic criteria. Results. Of 192 patients who had functional dyspepsia, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes accounted for 79.2%, 62.5%, and 50%, respectively. Multivariate analysis of the risk factors showed that independent predictors of postprandial distress syndrome were alcohol and irritable bowel syndrome while irritable bowel syndrome was independent predictor of epigastric pain syndrome. Alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs were independent predictors of cooccurrence of postprandial distress syndrome and epigastric pain syndrome. Conclusion. Functional dyspepsia accounts for 62.5% of dyspepsia in a population of black African patients. Regarding symptomatology, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes account for 79.2%, 62.5%, and 50%, respectively. Risk factors for functional dyspepsia are irritable bowel syndrome, alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs.
authors.affiliation: Gatroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku/Ozalla, PMB 01129, Enugu, Nigeria.
authors.forename: Sylvester Chuks
authors.initials: SC
authors.lastname: Nwokediuko
authors.forename: Uchenna
authors.initials: U
authors.lastname: Ijoma
authors.forename: Olive
authors.initials: O
authors.lastname: Obienu