title: An efficient total synthesis of (-)-epothilone B.
abstract: An efficient total synthesis of (-)-epothilone B has been achieved in ca. 8% yield over 11 steps from 9 (or 10 steps from 7/8), which features a bissiloxane-tethered ring closing metathesis reaction to approach the trisubstituted (Z) double bond and forms a new basis for further development of an industrial process for epothilone B and ixabepilone.
authors.affiliation: CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, CAS, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Bing-Feng
authors.initials: BF
authors.lastname: Sun
authors.forename: Kai
authors.initials: K
authors.lastname: Cui
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Lin
mesh_terms: D003500:Cyclization; D034261:Epothilones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D034261:Epothilones; C430592:ixabepilone; C093788:epothilone B