title: Cytogenetic analysis of a low-grade secondary peripheral chondrosarcoma arising in synovial chondromatosis.
abstract: Secondary chondrosarcoma is a malignant chondroid tumor arising in a benign precursor. Synovial chondromatosis is a benign chondroid lesion that rarely transforms to chondrosarcoma. We present the case of a 54-year-old male with the diagnosis of low-grade secondary peripheral chondrosarcoma developed in the context of synovial chondromatosis. Cytogenetics revealed a novel aberration t(1;14)(q23.1~24;q24.1~3). Multicolor banding (mBAND) analysis described the chromosomal regions involved in this translocation with a higher detail. Diagnosis of such borderline lesions is very difficult and cytogenetics is helpful in characterizing these tumors.
authors.affiliation: Department of Genetics, Saint Savvas Hospital, 171 Alexandras Avenue, 11522 Athens, Greece. tassoskyr@gmail.com
authors.forename: Anastasios I
authors.initials: AI
authors.lastname: Kyriazoglou
authors.forename: Helen
authors.initials: H
authors.lastname: Rizou
authors.forename: Efthimios
authors.initials: E
authors.lastname: Dimitriadis
authors.forename: Niki
authors.initials: N
authors.lastname: Arnogiannaki
authors.forename: Niki
authors.initials: N
authors.lastname: Agnantis
authors.forename: Nikos
authors.initials: N
authors.lastname: Pandis
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D015838:Chondromatosis, Synovial / Q000150:complications*; D002813:Chondrosarcoma / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D032681:Spectral Karyotyping / Q000379:methods*; D014178:Translocation, Genetic