title: [Regularity of drug use of patents in force of traditional Chinese medicine compounds in preventing and treating cardiovascular diseases on basis of frequency analysis].
abstract: OBJECTIVE
  To study the regularity of drug use of patents in force of traditional Chinese medicine compounds in treating cardiovascular diseases and provide reference for new drug R&D and patent protection.
  
  
  METHODS
  With long-lasting patents in force of traditional Chinese medicine compounds in treating cardiovascular diseases as the study object, the frequency analysis was made for studying their core ingredients, efficacy, channel tropism and drug compatibility.
  
  
  CONCLUSIONS
  There are nearly 30 frequently used traditional Chinese medicine compounds in treating cardiovascular diseases with patents in force including Salvia miltiorrhiza and Astragalus mongholicus, with main efficacy for promoting blood circulation and removing blood stasis and reinforcing Qi and the highest efficacy in heart, liver, spleen and lung channels. The results of this study provide reference and new room for development for R&D of traditional Chinese medicine compounds in treating cardiovascular diseases and patent protection.
authors.affiliation: Hebei Medical University, Shijiazhuang 050091, China. medicalhistory@sina.com
authors.forename: Xu-jie
authors.initials: XJ
authors.lastname: Yang
authors.forename: Shi-ying
authors.initials: SY
authors.lastname: Xiao
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy*; D004339:Drug Compounding / Q000706:statistics & numerical data*; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D010330:Patents as Topic; D008517:Phytotherapy / Q000706:statistics & numerical data*
chemical_list: D004365:Drugs, Chinese Herbal