title: HIFs, angiogenesis, and cancer.
abstract: Tumor hypoxia was first described in the 1950s by radiation oncologists as a frequent cause of failure to radiotherapy in solid tumors. Today, it is evident that tumor hypoxia is a common feature of many cancers and the master regulator of hypoxia, hypoxia-inducible factor-1 (HIF-1), regulates multiple aspects of tumorigenesis, including angiogenesis, proliferation, metabolism, metastasis, differentiation, and response to radiation therapy. Although the tumor hypoxia response mechanism leads to a multitude of downstream effects, it is angiogenesis that is most crucial and also most susceptible to molecular manipulation. The delineation of molecular mechanisms of angiogenesis has revealed a critical role for HIF-1 in the regulation of angiogenic growth factors. In this article, we review what has been described about HIF-1: its structure, its regulation, and its implication for cancer therapy and we focus on its role in angiogenesis and cancer.
authors.affiliation: Student Teams Research Management Unit, Second Military Medical University, Xiangyin Road, Shanghai 200433, P.R. China.
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Yang
authors.forename: Mingjuan
authors.initials: M
authors.lastname: Sun
authors.forename: Lianghua
authors.initials: L
authors.lastname: Wang
authors.forename: Binghua
authors.initials: B
authors.lastname: Jiao
mesh_terms: D000818:Animals; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051793:Hypoxia-Inducible Factor 1