title: Renal manifestations in 2007 Korean patients with Behçet's disease.
abstract: OBJECTIVE
  Behçet's disease (BD) theoretically affects all sizes and types of blood vessels and results in multi-organ involvement. However, renal BD has not been fully characterized, though the kidneys are histologically rich in blood vessels.
  
  
  METHODS
  A total of 2007 patients who fulfilled the diagnostic criteria for BD were enrolled in this study. We reviewed the medical records and test results of the BD patients and used univariate and multivariate logistic regression analyses to determine the clinical significance of renal involvement in BD.
  
  
  RESULTS
  Among the 2007 BD patients, we noted hematuria in 412 (20.5%) and proteinuria in 29 (1.4%). Univariate analysis showed that the BD patients with hematuria were predominantly female and older, had higher erythrocyte sedimentation rates (ESRs), and more frequently presented with genital ulcerations. BD patients with proteinuria had higher ESR levels compared to BD patients without proteinuria. In the multivariate analysis, age, sex, and ESR were found to be significantly associated with hematuria in BD patients, whereas only ESR was associated with proteinuria in BD patients. We also found that IgA nephropathy was the most common pathologic diagnosis in 12 renal BD patients who underwent renal biopsies.
  
  
  CONCLUSIONS
  We suggest that routine urinalysis and serum renal function tests be performed for the early detection of renal BD, especially in older female BD patients with recurrent hematuria, high ESR levels, and frequent genital ulcers, as well as in BD patients with proteinuria and high ESR levels.
authors.affiliation: Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sung Bin
authors.initials: SB
authors.lastname: Cho
authors.forename: Jihyun
authors.initials: J
authors.lastname: Kim
authors.forename: Shin-Wook
authors.initials: SW
authors.lastname: Kang
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Yoo
authors.forename: Zhenlong
authors.initials: Z
authors.lastname: Zheng
authors.forename: Suhyun
authors.initials: S
authors.lastname: Cho
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Lee
authors.forename: Dongsik
authors.initials: D
authors.lastname: Bang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001528:Behcet Syndrome / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism*; D001706:Biopsy; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000175:diagnosis; D006417:Hematuria / Q000150:complications / Q000175:diagnosis; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000175:diagnosis*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011507:Proteinuria / Q000150:complications / Q000175:diagnosis; D056910:Republic of Korea; D055815:Young Adult