title: Human CD27+IgM+IgD+ B cells: T-cell or TLR-dependent?
abstract: In this issue of Blood,Weller et al studied patients with rare immunodeficiencies to demonstrate a role for Toll-like receptors (TLRs) in homeostasis of human CD27+IgM+IgD+B cells.
authors.affiliation: Erasmus MC.
authors.forename: Menno C
authors.initials: MC
authors.lastname: van Zelm
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007072:Immunoglobulin D / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D053592:Interleukin-1 Receptor-Associated Kinases / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics*; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics*; D017472:Receptors, Interleukin-1 / Q000235:genetics*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000276:immunology*
chemical_list: D007072:Immunoglobulin D; D007075:Immunoglobulin M; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D053594:Myeloid Differentiation Factor 88; D017472:Receptors, Interleukin-1; C434984:TIRAP protein, human; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; C454130:UNC93B1 protein, human; C507773:IRAK4 protein, human; D053592:Interleukin-1 Receptor-Associated Kinases