title: Correlation of age and HRT use with breast density as assessed by Quantra™.
abstract: Breast density is a significant predictor in the risk of developing breast cancer. Several methods are available for assessing breast density, but most are subject to intra-observer variability and are unable to assess the breast as a three-dimensional structure. Using Quantra(™) to quantify breast density, we have correlated this with risk factors to determine what impact these variables have on breast density. Women attending for full field digital mammography at the South West London Breast Screening Unit between December 2008 and March 2009 were invited to participate in the study by questionnaire. Consenting women returned the questionnaire allowing further data collection including demographics, menopausal status and hormone replacement therapy (HRT) use. Data were correlated against breast density measurements to determine the degree of association. Mammograms were assessed on a Hologic(™) workstation and breast density calculated using Quantra(™). Quantra(™) is an automated algorithm for volumetric assessment of breast tissue composition from digital mammograms. Six-hundred and eighty-three women were invited to participate. Those with implants or mastectomy were excluded. Three-hundred and twenty questionnaires were fully completed and able to be assessed. The mean age of participants was 59 years (range 49-81). Mean density was 19.7% (range 8.5-48.5%). There was a decrease in density with age (Pearson product-moment correlation coefficient -0.17). Correlation between density and HRT use showed a significant positive result (correlation coefficient 0.07). Quantra(™) has shown to be an accurate, reproducible tool for quantifying breast density, demonstrated by its correlation with lifestyle and demographic data. Given its ease of acquisition this may be the future of breast density quantification in the digital age.
authors.affiliation: Department of Radiology, Frimley Park Hospital NHS Foundation Trust, Surrey, United Kingdom. pippa.skippage@gmail
authors.forename: Philippa
authors.initials: P
authors.lastname: Skippage
authors.forename: Louise
authors.initials: L
authors.lastname: Wilkinson
authors.forename: Steven
authors.initials: S
authors.lastname: Allen
authors.forename: Nicola
authors.initials: N
authors.lastname: Roche
authors.forename: Mitch
authors.initials: M
authors.lastname: Dowsett
authors.forename: Roger
authors.initials: R
authors.lastname: A'hern
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D015992:Body Mass Index; D000071060:Breast Density; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D042361:Mammary Glands, Human / Q000002:abnormalities; D008327:Mammography; D008593:Menopause; D008875:Middle Aged; D009929:Organ Size; D011856:Radiographic Image Enhancement; D012307:Risk Factors; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires