title: Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death.
abstract: Two hybrid compounds comprising an antimetastatic ruthenium-arene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent synergistic action between the two components observed.
authors.affiliation: Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology, 1015 Lausanne, Switzerland.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Nazarov
authors.forename: Daniel
authors.initials: D
authors.lastname: Gardini
authors.forename: Mathurin
authors.initials: M
authors.lastname: Baquié
authors.forename: Lucienne
authors.initials: L
authors.lastname: Juillerat-Jeanneret
authors.forename: Tatiana P
authors.initials: TP
authors.lastname: Serkova
authors.forename: Elena P
authors.initials: EP
authors.lastname: Shevtsova
authors.forename: Rosario
authors.initials: R
authors.lastname: Scopelliti
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dyson
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds