title: [Long-term follow-up after intravenous injection of mercury--two cases report].
abstract: In this paper we present the long-term follow-up of two patients, after injection of metallic mercury. Case 1. In 1997, 29-years-old man injected himself to left elbow about 20 ml of metallic mercury by mistake (he was heroin abuser for short time). Mercury concentration in the blood was 400 microg/L. X-ray of the chest, abdomen and affected elbow area showed radiopaque foreign material (depots of mercury). Depots of mercury were also visible on the tricuspid valve in echocardiography. Mercury from the soft tissue left elbow pit was partially surgically removed. During 15 years follow-up two times chelating therapy was performed with d-penicyllamine and DMPS. In 2012, he was admitted to hospital next time. The blood and urine mercury concentration was still elevated (55.2 microg/L and 197 microg/L), mercury depots in the lung and abdomen were present. The signs and symptoms of CNS damage, like peripheral polyneuropathy and ataxia, were diagnosed. CT of brain did not revealed any changes, despite head trauma before 6 years. However neurological findings are typical for chronic mercury poisoning, it is not possible to determine whether these changes are directly related to mercury, because head trauma history, Case 2. In 2003, 16-years-old woman injected herself one month before, in suicidal attempts to both elbows several millilitres of metallic mercury. Mercury concentration in the blood was 56.2 microg/L, in urine 906 microg/L and in the hair 1.12 microg/g. Chest Xray showed depots of mercury in the lung. Mercury from the soft tissue was two times surgically removed. During 9 years two times chelating therapy was performed with d-penicyllamine and DMPS. After 9 years there is no symptoms of mercury poisoning. Mercury depots in the lung are still present. The blood and urine mercury concentration is low (13.7 microg/L and 2.53 microg/L). In mean time she gave birth two healthy children. Further patients evaluation is necessary.
authors.affiliation: Oddział Toksykologii i Chorób Wewnetrznych, Szpitala Specjalistycznego im. Ludwika Rydygiera w Krakowie.
authors.forename: Halina
authors.initials: H
authors.lastname: Goszcz
authors.forename: Łucja
authors.initials: Ł
authors.lastname: Szczepańska
authors.forename: Teresa
authors.initials: T
authors.lastname: Lech
authors.forename: Barbara
authors.initials: B
authors.lastname: Groszek
mesh_terms: D000293:Adolescent; D000328:Adult; D002614:Chelating Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D008168:Lung / Q000737:chemistry; D008297:Male; D008628:Mercury / Q000008:administration & dosage / Q000097:blood / Q000652:urine; D008630:Mercury Poisoning / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy* / Q000652:urine; D010398:Penicillic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome; D013406:Suicide, Attempted; D016896:Treatment Outcome; D014494:Unithiol / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D002614:Chelating Agents; C028100:penicillamide; D014494:Unithiol; D008628:Mercury; D010398:Penicillic Acid