title: Taurine and atherosclerosis.
abstract: Taurine is abundantly present in most mammalian tissues and plays a role in many important physiological functions. Atherosclerosis is the underlying mechanism of cardiovascular disease including myocardial infarctions, strokes and peripheral artery disease and remains a major cause of morbidity and mortality worldwide. Studies conducted in laboratory animal models using both genetic and dietary models of hyperlipidemia have demonstrated that taurine supplementation retards the initiation and progression of atherosclerosis. Epidemiological studies have also suggested that taurine exerts preventive effects on cardiovascular diseases. The present review focuses on the effects of taurine on the pathogenesis of atherosclerosis. In addition, the potential mechanisms by which taurine suppress the development of atherosclerosis will be discussed.
authors.affiliation: R&D Headquarters, Self Medication Business, Taisho Pharmaceutical Co Ltd, 24-1 Takada 3-chome, Toshima-ku, Tokyo, 170-8633, Japan, s-murakami@so.taisho.co.jp.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Murakami
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000378:metabolism / Q000473:pathology; D009203:Myocardial Infarction / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D013654:Taurine / Q000378:metabolism*
chemical_list: D013654:Taurine