title: [A case of successful treatment of granulocyte colony-stimulating factor producing hepatocellular carcinoma accompanying type B hepatitis with tegafur-uracil].
abstract: A 37-year-old man underwent lobectomy of the right liver for granulocyte colony-stimulating factor (G-CSF) producing hepatocellular carcinoma accompanying type B hepatitis. Within two months after the surgery, lung metastases were revealed and administration of sorafenib was begun, however, the lung metastases continued to enlarge. Changing the patient's medication to tegafur-uracil provided remarkable reduction of the lung metastases. The patient is alive two years after diagnosis and receives outpatient chemotherapy. We concluded that this case is valuable with regard to the extreme rarity of G-CSF producing hepatocellular carcinoma and its successful treatment in this case.
authors.affiliation: Department of Internal Medicine, Toyota Kosei Hospital, Japan. tahkun56@yahoo.co.jp
authors.forename: Takanori
authors.initials: T
authors.lastname: Ito
authors.forename: Kenji
authors.initials: K
authors.lastname: Okubo
authors.forename: Masaya
authors.initials: M
authors.lastname: Shiomi
authors.forename: Michihiko
authors.initials: M
authors.lastname: Narita
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Morita
authors.forename: Atsufumi
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Hironobu
authors.initials: H
authors.lastname: Kanazawa
authors.forename: Junichi
authors.initials: J
authors.lastname: Shimizu
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Takeyama
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Hashizume
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shibahara
authors.forename: Daisaku
authors.initials: D
authors.lastname: Nishimura
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Katada
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Katano
authors.forename: Hidemi
authors.initials: H
authors.lastname: Goto
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D005641:Tegafur / Q000008:administration & dosage*; D014498:Uracil / Q000008:administration & dosage*
chemical_list: D000964:Antimetabolites, Antineoplastic; D016179:Granulocyte Colony-Stimulating Factor; D005641:Tegafur; D014498:Uracil