title: Effects of the serjania erecta and zeyheria montana ethanol extracts in experimental pulpitis in rats: a histological study.
abstract: OBJECTIVE
  The aim of this study was to evaluate, by the semi-quantitative histological analysis, the anti-inflammatory activity of the ethanolic extracts of Serjania erecta e Zeyheria Montana, in experimental pulpits in rats.
  
  
  METHODS
  In order to induce pulp inflammation, cavities were performed on the occlusal surface of the mandibular first molars of 45 male rats, without pulp exposure. The animals were distributed into 4 groups: GI, teeth without cavities; GII, single dose of saline solution via intraperitoneal (IP); GIII, single dose (IP) of 300 mg/Kg of ethanolic extract of Zeyheria montana; GIV, single dose (IP) of 300 mg/Kg of ethanolic extract of Serjania erecta. After 6, 12 and 24 hours, 5 animals of each group were killed by anesthetic overdose. The histological analyses of the pulp tissue were performed and the data analyzed by Dunn's multiple test, at significance of 5%.
  
  
  RESULTS
  After 12 h, the GIII presented score statistically lower (p<0.05) than positive control group. After 24 h, GIII presented inflammatory index statistically lower than the positive control (p<0.01) and Serjania erecta (p<0.05) groups.
  
  
  CONCLUSIONS
  The Zeyheria montana extract presented better anti-inflammatory activity than positive control group and Serjania erecta extract, which did not show anti-inflammatory effect in the analyzed periods.
authors.affiliation: School of Dentistry, University of Ribeirao Preto, Ribeirao Preto, Sao Paulo, Brazil.
authors.forename: Patrícia-Mara
authors.initials: PM
authors.lastname: Nossa
authors.forename: Leandro-Caetano
authors.initials: LC
authors.lastname: Guenka
authors.forename: Lucélio-Bernardes
authors.initials: LB
authors.lastname: Couto
authors.forename: Danyel-Elias
authors.initials: DE
authors.lastname: da-Cruz-Perez
mesh_terms: D000818:Animals; D000431:Ethanol; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011671:Pulpitis / Q000188:drug therapy* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D029631:Sapindaceae; D029663:Tabebuia
chemical_list: D010936:Plant Extracts; D000431:Ethanol