title: Prevalence, kinetic changes and possible reasons of elevated cardiac troponin T in patients with AV nodal re-entrant tachycardia.
abstract: BACKGROUND
  Elevated cardiac troponin (cTn) has been reported to occur with AVNRT. Little is known about prevalence, kinetic changes, and possible reasons of increased cTn.
  
  
  METHODS
  We evaluated 139 consecutive patients presenting with AVNRT to the emergency department between 2006 and 2010. Cardiac troponin T (cTnT) was measured serially at baseline, after three and six hours. Patients were evaluated for the presence of structural heart disease or CAD. Troponin was defined as elevated if a value exceeded the lower limit of detection (10 ng/l) using the fourth generation cTnT, or if the value > 99 th percentile (14 ng/l) using the new highly sensitive cTn assay.
  
  
  RESULTS
  A cTnT > LLD (n = 29) or > 99 th percentile (n = 16) was found in 45 patients (32.4%) within the initial six hours after hospitalization. All patients were symptomatic with palpitations, chest discomfort or dyspnea. A complete cardiac evaluation was carried out, including coronary angiography in 32 patients demonstrating an underlying structural heart disease or CAD in 18 cases (56%). Significant CAD was detected in 16 cases. 8 cases required PCI during hospitalization. Elevated cTnT was seen in patients with and without structural heart disease.
  
  
  CONCLUSIONS
  AVNRT is a possible reason for elevated cTnT, even in the absence of relevant structural heart disease or CAD.
authors.affiliation: Medizinische Klinik, Abteilung für Innere Medizin III, Universitätsklinikum Heidelberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Schueler
authors.forename: M
authors.initials: M
authors.lastname: Vafaie
authors.forename: R
authors.initials: R
authors.lastname: Becker
authors.forename: M
authors.initials: M
authors.lastname: Biener
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: M
authors.initials: M
authors.lastname: Mueller
authors.forename: E
authors.initials: E
authors.lastname: Giannitsis
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Katus
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000097:blood* / Q000453:epidemiology; D013617:Tachycardia, Supraventricular / Q000097:blood* / Q000453:epidemiology; D020107:Troponin T / Q000032:analysis*
chemical_list: D020107:Troponin T