title: Glycolic acid functionalized chitosan-Au-Fe₃O₄ hybrid nanoparticle based nanohybrid scaffold for drug delivery.
abstract: The research on biomedical applications of nanoparticles has seen an upsurge in recent years due to their unique capabilities in treatment of ailments. The present paper reports the synthesis of Au-Fe(3)O(4) hybrid nanoparticles. The formation of these nanoparticles was confirmed by transmission electron microscopy (TEM) and physical property measurement system (PPMS). Next step of this paper reveals potential use of novel hybrid of chitosan-g-glycolic acid and Au-Fe(3)O(4) hybrid nanoparticles in controlled drug delivery and tissue engineering applications. Grafting of glycolic acid and drug loading in porous scaffold was characterized by Fourier transform infrared spectroscopy. The nanohybrid scaffolds were found to be stable regardless of pH of the medium and play a key role in cell adhesion, proliferation and migration. Au-Fe(3)O(4) hybrid nanoparticles reinforcement was found to control the drug (cyclophosphamide) release rate in phosphate buffer saline solution (pH 7.4). Therefore, Au-Fe(3)O(4) hybrid nanoparticles are viable additive for formulating sustained drug delivery systems based on glycolic acid grafted chitosan. The cell proliferation profile also shows that prepared nanohybrid is biocompatible providing suitable substrates for tissue engineering.
authors.affiliation: Division of Polymer Science and Engineering, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, Maharashtra, India.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Kumari
authors.forename: Raj Pal
authors.initials: RP
authors.lastname: Singh
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D003520:Cyclophosphamide / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry* / Q000494:pharmacology; D006016:Glycolates / Q000737:chemistry* / Q000494:pharmacology; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D060328:Magnetic Phenomena; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D017550:Spectroscopy, Fourier Transform Infrared; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; D006016:Glycolates; C031149:glycolic acid; C000499:ferric oxide; D006046:Gold; D003520:Cyclophosphamide; D048271:Chitosan