title: Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.
abstract: A new sequential tristhiazole-thiazoline-containing cyclic peptide, marthiapeptide A (1), was isolated from a 60 L scale culture of the deep South China Sea-derived strain Marinactinospora thermotolerans SCSIO 00652. The planar structure and absolute configuration of 1 were elucidated by application of spectroscopic techniques, as well as by single-crystal X-ray diffraction and chiral-phase HPLC analysis of the acid hydrolysates. Marthiapeptide A (1) exhibited antibacterial activity against a panel of Gram-positive bacteria, with MIC values ranging from 2.0 to 8.0 μg/mL, and displayed strong cytotoxic activity against a panel of human cancer cell lines with IC(50) values ranging from 0.38 to 0.52 μM.
authors.affiliation: CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhou
authors.forename: Hongbo
authors.initials: H
authors.lastname: Huang
authors.forename: Yuchan
authors.initials: Y
authors.lastname: Chen
authors.forename: Jiaheng
authors.initials: J
authors.lastname: Tan
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Song
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zou
authors.forename: Xinpeng
authors.initials: X
authors.lastname: Tian
authors.forename: Yan
authors.initials: Y
authors.lastname: Hua
authors.forename: Jianhua
authors.initials: J
authors.lastname: Ju
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002681:China; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006094:Gram-Positive Bacteria / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009792:Oceans and Seas; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; D013844:Thiazoles; C578642:marthiapeptide A