title: Adipokine adiponectin is a potential protector to human bronchial epithelial cell for regulating proliferation, wound repair and apoptosis: comparison with leptin and resistin.
abstract: Epidemiological data indicate an increasing incidence of asthma in the obese individuals recent decades, while very little is known about the possible association between them. Here, we compared the roles of adipocyte-derived factors, including leptin, adiponectin and resistin on proliferation, wound repair and apoptosis in human bronchial epithelial cells (HBECs) which play an important role in the pathogenesis of asthma. The results showed that exogenous globular adiponectin (gAd) promoted proliferation, cell-cycle and wound repair of HBECs. This effect may be relevant to Ca(2+)/calmodulin signal pathway. Besides, gAd inhibited apoptosis induced by ozone and release of lactate dehydrogenase (LDH) of HBECs via regulated adipoR1 and reactive oxygen species. No effects of leptin or resistin on proliferation, wound repair and apoptosis of HBECs were detectable. These data indicate that airway epithelium is the direct target of gAd which plays an important role in protecting HBECs from mechanical or oxidant injuries and may have therapeutic implications in the treatment of asthma.
authors.affiliation: Department of Physiology, School of Basic Medical Science Central South University, Changsha, China.
authors.forename: Xiao Lin
authors.initials: XL
authors.lastname: Zhu
authors.forename: Xiao Qun
authors.initials: XQ
authors.lastname: Qin
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiang
authors.forename: Yu Rong
authors.initials: YR
authors.lastname: Tan
authors.forename: Xiang Pin
authors.initials: XP
authors.lastname: Qu
authors.forename: Hui Jun
authors.initials: HJ
authors.lastname: Liu
mesh_terms: D052242:Adiponectin; D017209:Apoptosis; D001249:Asthma / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D001980:Bronchi / Q000166:cytology / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D049109:Cell Proliferation / Q000187:drug effects*; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000008:administration & dosage; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D052243:Resistin / Q000008:administration & dosage; D014945:Wound Healing
chemical_list: D052242:Adiponectin; D020738:Leptin; D017382:Reactive Oxygen Species; D052243:Resistin; D002118:Calcium