title: A new norditerpenoid from Euonymus grandiflorus Wall.
abstract: A new norditerpenoid 1, as well as 15 known terpenoids 2-16, was isolated from the ethanol extract of the branches and leaves of Euonymus grandiflorus Wall. The structures of these compounds were elucidated mainly due to spectroscopic methods (1D NMR, 2D NMR, ESI-MS and HR-ESI-MS). Compound 11, betulinic acid, displayed moderate cytotoxicity against four human tumor cell lines A549, HCT116, SK-BR-3 and HepG2, with IC50 values of 10.3, 12.2, 3.6 and 4.5 μg/mL, respectively.
authors.affiliation: a Shenyang Pharmaceutical University , Shenyang Liaoning Province 110016 , P.R. China.
authors.forename: Changxia
authors.initials: C
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Ji
authors.initials: J
authors.lastname: Ye
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
authors.forename: Yunheng
authors.initials: Y
authors.lastname: Shen
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D029756:Euonymus / Q000737:chemistry*; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes; D018515:Plant Leaves / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology; D000094062:Betulinic Acid
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D053978:Pentacyclic Triterpenes; D013729:Terpenes; D014315:Triterpenes; D000094062:Betulinic Acid