title: Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice.
abstract: Ezrin is a member of the ezrin-radixin-moesin (ERM) family of proteins, which link the cytoskeleton and cell membrane. ERM proteins are involved in pivotal cellular functions including cell-matrix recognition, cell-cell communication, and cell motility. Several recent studies have shown that ERM proteins are expressed in specific cell types of the adult rostral migratory stream (RMS). In this study, we found that ERM proteins are expressed highly in the early postnatal RMS and the ventricular zone of embryonic cerebral cortex, suggesting that these proteins may be expressed by neural progenitors. Furthermore, whereas ezrin previously was found to be expressed exclusively by astrocytes of the adult RMS, we found that ezrin-expressing cells also expressed the markers for indicating neuroblasts in vivo and in vitro, and that ezrin expression by neuroblasts decreases progressively as neuroblasts migrate. Using in vitro differentiation of adult neural stem cells, we found that ezrin is expressed by neural stem cells and their progeny (neuroblasts and astrocytes), but not by oligodendrocytic progeny. Collectively our findings demonstrate that adult neural stem cells and neuroblasts express ezrin and that ezrin may be involved in intracellular actin remodeling.
authors.affiliation: Department of Anatomy and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, Seoul 136-705, Korea.
authors.forename: Younghye
authors.initials: Y
authors.lastname: Moon
authors.forename: Joo Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: So Yoen
authors.initials: SY
authors.lastname: Choi
authors.forename: Hyo Min
authors.initials: HM
authors.lastname: Cho
authors.forename: Hyun
authors.initials: H
authors.lastname: Kim
authors.forename: Woong
authors.initials: W
authors.lastname: Sun
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism*; D001921:Brain / Q000166:cytology* / Q000196:embryology / Q000254:growth & development*; D002454:Cell Differentiation; D003598:Cytoskeletal Proteins / Q000032:analysis* / Q000096:biosynthesis; D020547:Lateral Ventricles / Q000166:cytology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D058953:Neural Stem Cells / Q000166:cytology* / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D000099149:Ezrin
chemical_list: D003598:Cytoskeletal Proteins; D000099149:Ezrin