title: The untapped potential of Gallium 68-PET: the next wave of ⁶⁸Ga-agents.
abstract: (68)Gallium-PET ((68)Ga-PET) agents have significant clinical promise. The radionuclide can be produced from a (68)Ge/(68)Ga generator on site and is a convenient alternative to cyclotron-based PET isotopes. The short half-life of (68)Ga permits imaging applications with sufficient radioactivity while maintaining patient dose to an acceptable level. Furthermore, due to superior resolution, (68)Ga-PET agents have the ability to replace current SPECT agents in many applications. This article outlines the upcoming agents and challenges faced during the translational development of (68)Ga agents.
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston TX, USA.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Smith
authors.forename: Wouter A P
authors.initials: WA
authors.lastname: Breeman
authors.forename: Jennifer
authors.initials: J
authors.lastname: Sims-Mourtada
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005710:Gallium Radioisotopes; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D006207:Half-Life; D007340:Insulinoma / Q000000981:diagnostic imaging; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging; D015282:Octreotide / Q000031:analogs & derivatives; D009842:Oligopeptides / Q000378:metabolism; D009942:Organometallic Compounds; D049268:Positron-Emission Tomography / Q000379:methods*; D011876:Radionuclide Generators; D019275:Radiopharmaceuticals; D018004:Receptors, Bombesin / Q000378:metabolism; D017481:Receptors, Somatostatin / Q000378:metabolism; D061905:Single-Domain Antibodies / Q000378:metabolism; D013004:Somatostatin / Q000031:analogs & derivatives / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D018004:Receptors, Bombesin; D017481:Receptors, Somatostatin; D061905:Single-Domain Antibodies; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D013004:Somatostatin; C047981:arginyl-glycyl-aspartic acid; D052216:Glucagon-Like Peptide 1; C513399:gallium Ga 68 dotatate; C076668:AOC3 protein, human; D006631:Amine Oxidase (Copper-Containing); D015282:Octreotide; C106246:Edotreotide