title: Angiogenin variants are not associated with Parkinson's disease in the ethnic Chinese population.
abstract: Recently, the angiogenin gene has been reported to be significantly associated with Parkinson's disease and amyotrophic lateral sclerosis in populations of European and American ancestry. But there have been no studies investigating the association between angiogenin and Parkinson's disease in the ethnic Chinese population. We conducted a case-control study to evaluate the association between angiogenin and Parkinson's disease in a Chinese population from mainland China. We sequenced the exons of angiogenin in 532 Parkinson's disease patients and 480 controls. We did not detect an angiogenin coding region mutation in either the patients or the controls. Our data do not support the association of angiogenin variants with PD in Han Chinese of mainland China.
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Qin
authors.initials: Q
authors.lastname: Xiao
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yang
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Jianfang
authors.initials: J
authors.lastname: Ma
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Quinn
authors.forename: Sheng-di
authors.initials: SD
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004252:DNA Mutational Analysis; D005006:Ethnicity / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012259:Ribonuclease, Pancreatic / Q000235:genetics*; D055815:Young Adult
chemical_list: C046366:angiogenin; D012259:Ribonuclease, Pancreatic