title: 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease.
abstract: Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [(18)F], was synthesised in radiofluorinated form. PET/CT Imaging with [(18)F] identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.
authors.affiliation: Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK.
authors.forename: Elisa
authors.initials: E
authors.lastname: Calamai
authors.forename: Sergio
authors.initials: S
authors.lastname: Dall'Angelo
authors.forename: David
authors.initials: D
authors.lastname: Koss
authors.forename: Juozas
authors.initials: J
authors.lastname: Domarkas
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: McCarthy
authors.forename: Marco
authors.initials: M
authors.lastname: Mingarelli
authors.forename: Gernot
authors.initials: G
authors.lastname: Riedel
authors.forename: Lutz F
authors.initials: LF
authors.lastname: Schweiger
authors.forename: Andy
authors.initials: A
authors.lastname: Welch
authors.forename: Bettina
authors.initials: B
authors.lastname: Platt
authors.forename: Matteo
authors.initials: M
authors.lastname: Zanda
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000235:genetics; D016229:Amyloid beta-Peptides / Q000032:analysis* / Q000235:genetics; D000818:Animals; D001463:Barbiturates / Q000737:chemistry; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging* / Q000235:genetics; D049268:Positron-Emission Tomography / Q000379:methods; D015854:Up-Regulation; D016875:tau Proteins / Q000032:analysis
chemical_list: D016229:Amyloid beta-Peptides; D001463:Barbiturates; D005462:Fluorine Radioisotopes; D016875:tau Proteins