title: [Intraoperative fluorescent visualization and laser spectrosopy in intrinsic brain tumor surgery].
abstract: Absence of well-defined borders of the glial tumor due to their infiltrative growth is one of the main issues in neurosurgery. A number of methods for intraoperative visualization are available today. The fluorescent metabolic navigation with 5-aminolevulinic acid (5-ALA) combined with quantitative laser spectroscopy is one of the latest technique. In our series of 99 consecutive patients with brain gliomas (WHO Grade I-IV) we found that visible fluorescence was observed in 68% of cases. Additional use of the laser spectroscopy could increase method sensitivity up to 74% due to accumulation of the protoporphyrine IX in nonfluorescense tumors. It was shown that there are some differences in quantitative fluorescence not only within same tumor (glioblastoma) but also in-between low- and high-grade gliomas. Intraoperative fluorescence and laser spectroscopy are effective and very helpful methods of intraoperative imaging in of intrinsic brain tumor surgery.
authors.forename: A A
authors.initials: AA
authors.lastname: Potapov
authors.forename: A G
authors.initials: AG
authors.lastname: Gavrilov
authors.forename: S A
authors.initials: SA
authors.lastname: Goriaĭnov
authors.forename: D A
authors.initials: DA
authors.lastname: Gol'bin
authors.forename: P V
authors.initials: PV
authors.lastname: Zelenkov
authors.forename: G L
authors.initials: GL
authors.lastname: Kobiakov
authors.forename: V A
authors.initials: VA
authors.lastname: Okhlopkov
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Zhukov
authors.forename: L V
authors.initials: LV
authors.lastname: Shishkina
authors.forename: V A
authors.initials: VA
authors.lastname: Shukhraĭ
authors.forename: V B
authors.initials: VB
authors.lastname: Loshchenov
authors.forename: T A
authors.initials: TA
authors.lastname: Savel'eva
authors.forename: P V
authors.initials: PV
authors.lastname: Grachev
authors.forename: M N
authors.initials: MN
authors.lastname: Kholodtsova
authors.forename: S G
authors.initials: SG
authors.lastname: Kuz'min
authors.forename: G N
authors.initials: GN
authors.lastname: Vorozhtsov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000295:instrumentation* / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D011524:Protoporphyrins / Q000008:administration & dosage*; D013050:Spectrometry, Fluorescence
chemical_list: D017319:Photosensitizing Agents; D011524:Protoporphyrins; D000622:Aminolevulinic Acid; C028025:protoporphyrin IX