title: The obesity risk gene FTO influences body mass in chronic schizophrenia but not initial antipsychotic drug-induced weight gain in first-episode patients.
abstract: Genetic factors contribute to the individual variability in weight gain caused by several antipsychotic drugs. The FTO gene is associated with obesity in the general population; we have investigated whether a common risk polymorphism (rs9939609) in this gene is associated with antipsychotic drug-induced weight gain and obesity. Two samples were studied: (1) 93 first-episode patients receiving antipsychotic drugs for the first time and having body weight monitored for up to 12 months; (2) 187 chronic patients with schizophrenia assessed for measures of obesity and metabolic dysfunction. No association of FTO genotype with weight gain was found in initially drug-naive patients. The chronically treated patients had a significant association of genotype with body mass index (BMI), reflected in associations with waist circumference, waist:hip ratio and the frequency of central obesity. These findings indicate that FTO genotype has a major effect on body weight determined by BMI in chronically treated patients with schizophrenia.
authors.affiliation: Department of Psychiatry, Queen's University Belfast, Belfast, UK. gavin.reynolds@shu.ac.uk
authors.forename: Gavin P
authors.initials: GP
authors.lastname: Reynolds
authors.forename: Olga O
authors.initials: OO
authors.lastname: Yevtushenko
authors.forename: Sarah
authors.initials: S
authors.lastname: Gordon
authors.forename: Belen
authors.initials: B
authors.lastname: Arranz
authors.forename: Luis
authors.initials: L
authors.lastname: San
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Cooper
mesh_terms: D000293:Adolescent; D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects / Q000235:genetics*; D002908:Chronic Disease; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications* / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy / Q000235:genetics*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human