title: [Influence of soysaponins on blood lipid and grume of rats].
abstract: OBJECTIVE
  To study the influence of soysaponins on blood lipid and grume of the rats.
  
  
  METHODS
  According to their levels of cholesterol in serum and weight, 48 SD healthy male rats were randomly divided into groups, normal control, high fat control, high fat with 10 mg/kg aspirin, high fat with soyasaponins (20, 40 and 80 mg/kg). 10 weeks after gastric lavage, determined total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and grume indices.
  
  
  RESULTS
  As compared to high fat control, soyasaponins significantly reduced the serum TC (high fat control 2.19, soyasaponins group 1.86, 1.85 and 1.72 mmol/L), TG and LDL-C concentrations, increased the HDL-C levels distinctly. Compared with model group, aspirin group, soyasaponins group of activated partial thromboplastin time (high fat control 60.50s, aspirin group 68.10s, soyasaponins group 66.75s, 67.33s and 67.67s), prothrombin time (high fat control 13.15s, aspirin group 18.00s, soyasaponins group 17.00, 17.43 and 18.43s) higher than the model group, plasma fibrinogen decreased (high fat control 2.51 g/L, aspirin group 2.18g/L, soyasaponins group 2.29, 2.25 and 2.10 g/L).
  
  
  CONCLUSIONS
  It demonstrated that the soysaponins could adjust blood fat, reduce whole blood viscosity and improve blood viscosity. It is favorable to prevent cardiovascular and cerebrovascular diseases.
authors.affiliation: Department of Nutrition and Food Hygiene, Shanxi Medical University, Taiyuan 030001, China. wangzx19@163.com
authors.forename: Zhongxia
authors.initials: Z
authors.lastname: Wang
authors.forename: Lijie
authors.initials: L
authors.lastname: Du
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects; D006949:Hyperlipidemias / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D013025:Glycine max / Q000737:chemistry*
chemical_list: D008055:Lipids; D012503:Saponins