title: Clinical analysis of 240 patients with HLA-B27 associated acute anterior uveitis.
abstract: OBJECTIVE
  To analyze the prevalence of HLA-B27 associated acute anterior uveitis and to identify its clinical features.
  
  
  METHODS
  A total of 240 patients with HLA-B27 associated acute anterior uveitis, who were admitted to Zhejiang Ophthalmologic Hospital between December 2006 and October 2012, were retrospectively analyzed. The age of onset, sex, affected eyes, HLA-B27 antigen detection, recurrence, joint involvement, and surgical complications were investigated.
  
  
  RESULTS
  The average age of onset was 37.0±12.0 years and the ratio of male to female patients was 2.4:1. Most cases had alternate unilateral or bilateral involvement. Among all participants, 234 cases (97.5%) were HLA-B27 positive, and 124 cases (51.7%) had spondyloarthropathies (SpA), dominated by 108 cases with ankylosing spondylitis (AS,45.0%), and mostly seen in male subjects (P<0.05). Six patients were HLA-B27 negative (2.5%) and no statistical significance was noted between male and female patients (P>0.05). A total of 193 cases (80.4%) presented with complications, mainly fibrinous exudation, posterior synechia, and vitreous opacity.
  
  
  CONCLUSIONS
  HLA-B27 that is associated acute anterior uveitis with a relatively high incidence and recurrence presents with more severe clinical features than does idiopathic acute anterior uveitis, and it often accompanies systemic arthritic diseases. HLA-B27 antibody detection is associated with the diagnosis and treatment of acute anterior uveitis.
authors.affiliation: 1. Zhejiang Ophthalmologic Hospital,Eye Hospital of Wenzhou Medical College, Wenzhou 325027, China; 2. Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
authors.forename: Mei Qin
authors.initials: MQ
authors.lastname: Zheng
authors.forename: Yu Qin
authors.initials: YQ
authors.lastname: Wang
authors.forename: Xiao Ya
authors.initials: XY
authors.lastname: Lu
authors.forename: Yu Lin
authors.initials: YL
authors.lastname: Wang
authors.forename: Li Ping
authors.initials: LP
authors.lastname: Mao
authors.forename: Yun Feng
authors.initials: YF
authors.lastname: Gu
authors.forename: Peng Fei
authors.initials: PF
authors.lastname: Chen
mesh_terms: D000208:Acute Disease; D000328:Adult; D017668:Age of Onset; D005260:Female; D015796:HLA-B27 Antigen; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009885:Ophthalmology; D015995:Prevalence; D012008:Recurrence; D012189:Retrospective Studies; D025242:Spondylarthropathies / Q000453:epidemiology; D013167:Spondylitis, Ankylosing / Q000453:epidemiology; D014606:Uveitis, Anterior / Q000453:epidemiology* / Q000276:immunology*
chemical_list: D015796:HLA-B27 Antigen