title: Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease.
abstract: Alkenylboronic acids have shown important biological activities that contribute to neuroprotection. We have determined their influence on the β-amyloid (βA) aggregation process, β-secretase and acethylcholinesterase activities on cell-free systems, on the redox and lipid peroxidation status, and on the vulnerability to apoptotic death in an APPswe neuroblastoma cell line, before and after hydrogen peroxide treatment. We have discovered that 2-arylvinylboronic acids and some of their esters possess a set of properties which makes them highly useful as neuroprotective agents affecting multiple biological targets involved in AD. These properties are not paralleled by the related 2-arylboronic acids.
authors.affiliation: Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
authors.forename: Karim
authors.initials: K
authors.lastname: Jiménez-Aligaga
authors.forename: Paloma
authors.initials: P
authors.lastname: Bermejo-Bescós
authors.forename: Sagrario
authors.initials: S
authors.lastname: Martín-Aragón
authors.forename: Aurelio G
authors.initials: AG
authors.lastname: Csákÿ
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000544:Alzheimer Disease / Q000188:drug therapy*; D017209:Apoptosis / Q000187:drug effects*; D001897:Boronic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D055808:Drug Discovery; D006801:Humans; D008954:Models, Biological; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000475:Alkenes; D001897:Boronic Acids; D018696:Neuroprotective Agents