title: [Changes to surfactant proteins in the bronchoalveolar lavage fluid and serum of children with Mycoplasma pneumoniae pneumonia].
abstract: OBJECTIVE
  To study the changes to surfactant proteins in the serum and bronchoalveolar lavage fluids (BALF) of children with Mycoplasma pneumoniae pneumonia (MPP) and their significance.
  
  
  METHODS
  Self-control method was used in the study. Forty-seven MPP children were divided into single lung infected (n=32) and bilateral lung infected groups (n=15) according to lung CT results. Surfactant proteins SP-A, B, C and D were measured using ELISA in the serum and BALF in the two groups. The correlations between SP-A, B, C and D content in the serum and BALF were evaluated by Spearman correlation analysis.
  
  
  RESULTS
  SP-A, B, C and D content in BALF from the majorly infected or infected lung were significantly higher than from the opposite lung and serum (P<0.01). SP-A, B and C content in serum was significantly lower than in BALF from the non-infected lung in the single-side infected lung group (P<0.01 or 0.05), but there was no significant difference between serum SP-D content and BALF SP-D content from the non-infected lung. There were no significant differences in SP-A, B, C and D content in serum and BALF from the minorly infected lung in the bilateral lung infected group. Serum SP-D content was positively correlated with BALF SP-D content from the majorly infected lung in the bilateral lung infected group (P<0.01).
  
  
  CONCLUSIONS
  Serum SP-D content may serve as a biomarker for evaluating the severity of pulmonary infection in children with community-acquired pneumonia.
authors.affiliation: Department of Pediatric Pulmonology, China Medical University, Shenyang, China. shulinhua@126.com
authors.forename: Lin-Hua
authors.initials: LH
authors.lastname: Shu
authors.forename: Yun-Xiao
authors.initials: YX
authors.lastname: Shang
authors.forename: Xu-Xu
authors.initials: XX
authors.lastname: Cai
authors.forename: Han
authors.initials: H
authors.lastname: Zhang
authors.forename: Miao
authors.initials: M
authors.lastname: Li
authors.forename: Qian-Lan
authors.initials: QL
authors.lastname: Zhou
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Zong
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Meng
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
mesh_terms: D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011019:Pneumonia, Mycoplasma / Q000378:metabolism*; D011663:Pulmonary Surfactants / Q000032:analysis* / Q000097:blood
chemical_list: D011663:Pulmonary Surfactants