title: [Study on the immunocompetence of polysaccharide extracted from root of Salvia miltiorrhiza].
abstract: OBJECTIVE
  To study the immune activity of polysaccharide extracted from root of Salvia miltiorrhiza.
  
  
  METHODS
  Investigated the effects of polysaccharide extracted from root of Salvia miltiorrhiza on lymphocyte proliferation response of mouse induced by LPS (the lipopolysaccharide LPS), phagocytosis of the peritoneal macrophage of mice to chick erythrocytes and the mouse models of delayed type hypersensitivity (DTH) response induced by DNFB.
  
  
  RESULTS
  Lymphocyte proliferation and phagocytosis of the peritoneal macrophage of mice could be promoted by the polysaccharide, which could inhibit ear edema and capillary permeability increase induced by DNFB and enlarged the thymus and splenic index in mice. The expression of iNOS, IFN-alpha and IL-1beta was inhibited significantly in the treatment group.
  
  
  CONCLUSIONS
  The polysaccharide extracted from Salvia miltiorrhiza can improve immune function.
authors.affiliation: Guangzhou Hanfang Pharmaceutical Company Limited/National Engineer Research Center for Modernization of Extraction and Separation of Traditional Chinese Medicine (TCM), Guangzhou 510240, China. hfxd@163.com
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Zhang
authors.forename: Ding-Zhou
authors.initials: DZ
authors.lastname: Xu
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Fa-Huan
authors.initials: FH
authors.lastname: Ge
authors.forename: Li
authors.initials: L
authors.lastname: Yang
mesh_terms: D000818:Animals; D004139:Dinitrofluorobenzene / Q000008:administration & dosage; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D007121:Immunocompetence / Q000187:drug effects*; D007371:Interferon-gamma / Q000235:genetics / Q000378:metabolism; D008070:Lipopolysaccharides / Q000008:administration & dosage; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D018517:Plant Roots / Q000737:chemistry; D011134:Polysaccharides / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D013154:Spleen / Q000187:drug effects / Q000276:immunology
chemical_list: D008070:Lipopolysaccharides; D011134:Polysaccharides; D012333:RNA, Messenger; D007371:Interferon-gamma; D004139:Dinitrofluorobenzene; D019001:Nitric Oxide Synthase