title: Overcoming HLA restriction in clinical trials: Immune monitoring of mRNA-loaded DC therapy.
abstract: A decade of collective work by tumor immunologists has led to improved large scale generation, maturation, antigen loading and administration of dendritic cells (DCs) to cancer patients, promoting enhanced antitumor activity. We alleviated the HLA-restriction in DC therapy and demonstrated that it is meaningful to treat patients with DCs irrespective of their HLA type.
authors.affiliation: Laboratory of Molecular and Cellular Therapy; Department of Immunology-Physiology; Medical School of the Vrije Universiteit Brussel (VUB); Brussels, Belgium.
authors.forename: An M T
authors.initials: AM
authors.lastname: Van Nuffel
authors.forename: Sofie
authors.initials: S
authors.lastname: Wilgenhof
authors.forename: Kris
authors.initials: K
authors.lastname: Thielemans
authors.forename: Aude
authors.initials: A
authors.lastname: Bonehill