title: Synchronous occurrence of multiple focal nodular hyperplasia and huge hepatic perivascular epithelioid cells tumor (PEComa) in young woman after oral contraceptive use--is there a common pathogenesis?
abstract: The association of focal nodular hyperplasia (FNH) and various neoplasms was described, but coincidence of multiple FNH and hepatic perivascular epithelioid cells tumor (PEComa) has not been reported. The clinical debate of oral contraceptive (OC) influence on FNH growth is ongoing, but no evidence exists about association of hepatic PEComa with OC use.     Herein, we report a case of two FNH lesions and huge (150x100x80 mm) left hepatic lobe PEComa that occurred simultaneously in 18-year-old female with previous two year history of OC use, who underwent left hemihepatectomy and right hepatic FNH enucleation. Up to date, the patient has been followed-up for 65 months and remained disease-free.     FNH and PEComa have a common vascular cytogenetic denominator. Our case raising a question of a causal relationship of FNH and PEComa with OC use that might be attributed to vascular changes. Future researches of larger sample sizes should further address this issue.
authors.forename: Adam
authors.initials: A
authors.lastname: Durczyński
authors.forename: Piotr
authors.initials: P
authors.lastname: Hogendorf
authors.forename: Dariusz
authors.initials: D
authors.lastname: Szymański
authors.forename: Stanisław
authors.initials: S
authors.lastname: Sporny
authors.forename: Janusz
authors.initials: J
authors.lastname: Strzelczyk
mesh_terms: D000293:Adolescent; D002763:Cholecystectomy; D003276:Contraceptives, Oral / Q000009:adverse effects*; D015622:Epithelioid Cells / Q000473:pathology; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000139:chemically induced* / Q000473:pathology; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D054973:Perivascular Epithelioid Cell Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D003276:Contraceptives, Oral