title: IL28B single-nucleotide polymorphism rs12979860 is associated with spontaneous HIV control in white subjects.
abstract: The single-nucleotide polymorphism (SNP) rs12979860 near the IL28B gene has been associated with the spontaneous clearance of hepatitis C virus. We sought to determine whether this SNP could be associated with the spontaneous control of human immunodeficiency virus (HIV) infection. We studied the prevalence of the IL28B CC genotype among 53 white HIV controllers, compared with the prevalence among 389 HIV-infected noncontrollers. We found that the IL28B CC genotype was independently associated with spontaneous HIV control (odds ratio [OR], 2.669; P = .017), as were female sex (OR, 7.077; P ≤ .001) and the presence of HLA-B57 and/or B27 (OR, 3.080; P = .017). This result supports the idea that common host mechanisms are involved in the spontaneous control of these 2 chronic infections.
authors.affiliation: Laboratory of Immunovirology, Biomedicine Institute of Seville, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Seville, Spain.
authors.forename: Kawthar
authors.initials: K
authors.lastname: Machmach
authors.forename: Christina
authors.initials: C
authors.lastname: Abad-Molina
authors.forename: María C
authors.initials: MC
authors.lastname: Romero-Sánchez
authors.forename: María A
authors.initials: MA
authors.lastname: Abad
authors.forename: Sara
authors.initials: S
authors.lastname: Ferrando-Martínez
authors.forename: Miguel
authors.initials: M
authors.lastname: Genebat
authors.forename: Ildefonso
authors.initials: I
authors.lastname: Pulido
authors.forename: Pompeyo
authors.initials: P
authors.lastname: Viciana
authors.forename: María F
authors.initials: MF
authors.lastname: González-Escribano
authors.forename: Manuel
authors.initials: M
authors.lastname: Leal
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Ruiz-Mateos
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D015235:HLA-B Antigens / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000235:genetics / Q000276:immunology / Q000821:virology; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019562:Viral Load; D044465:White People / Q000235:genetics*; D000095022:Interferon Lambda
chemical_list: D015235:HLA-B Antigens; D007372:Interferons; D007378:Interleukins; C103707:HLA-B57 antigen; C000624353:interferon-lambda, human; D000095022:Interferon Lambda