title: Hyperuricemia and metabolic syndrome: lessons from a large cohort from Israel.
abstract: BACKGROUND
  There is a striking increase in the number of people with metabolic syndrome (MetS) as a result of the global epidemic of obesity and diabetes. Increasing evidence suggests that uric acid may play a role in MetS.
  
  
  OBJECTIVE
  To assess the prevalence of MetS in a large cohort from Israel and its association with hyperuricemia using the latest three definitions of MetS.
  
  
  METHODS
  We conducted a retrospective analysis of the database from a screening center in Israel, using the revised National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), the International Diabetes Federation (IDF) and the Harmonizing definitions of MetS, to assess 12,036 subjects with an age range of 20-80 years.
  
  
  RESULTS
  The mean age of the study sample was 46.1 +/- 10.2 years and 69.8% were male. The prevalence of MetS was 10.6%, 18.2% and 20.2% in the revised NCEP ATP III, the IDF and the Harmonizing definitions respectively. The prevalence of hyperuricemia in subjects with MetS, for all three MetS definitions, was similar: 20.0%, 19.9% and 19.1% respectively. There was a graded increase in the prevalence of MetS among subjects with increasing levels of uric acid. The increasing trend persisted after stratifying for age and gender and after multivariate analysis (P for trend (0.001).
  
  
  CONCLUSIONS
  This large cohort shows a high prevalence of MetS in Israel, but is still lower than the prevalence in western countries. Hyperuricemia is common in those subjects and might be considered a potential clinical parameter in the definition of MetS.
authors.affiliation: Recanati Center for Medicine and Research, Petah Tikva, Israel. dreytancohen@gmail.com
authors.forename: Eytan
authors.initials: E
authors.lastname: Cohen
authors.forename: Ilan
authors.initials: I
authors.lastname: Krause
authors.forename: Abigail
authors.initials: A
authors.lastname: Fraser
authors.forename: Elad
authors.initials: E
authors.lastname: Goldberg
authors.forename: Moshe
authors.initials: M
authors.lastname: Garty
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D007333:Insulin Resistance / Q000502:physiology*; D007557:Israel / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D014527:Uric Acid