title: [Pulmonary involvement due to HHV-8 virus during the course of HIV infection].
abstract: HHV-8 is a herpes virus discovered in 1994 in Kaposi sarcoma cells. Its involvement was later demonstrated in multicentric Castleman disease and in primary lymphoma effusion lymphoma. These diseases arise almost exclusively in immunocompromised patients, mostly in association with HIV infection. Apart from Kaposi's sarcoma, combined antiretroviral therapy does not seem to have reduced the incidence of these diseases, which remain rare. In these three diseases, pulmonary involvement is common and may be the presenting feature. Kaposi's sarcoma of the lung is usually asymptomatic but may require specific therapy. Pulmonary involvement is mostly associated with cutaneous disease. Patients with Castleman disease typically present with fever and lymphadenopathy, associated with interstitial lung disease without opportunistic infection. Patients with primary lymphoma effusion presents with fever and an exudative lymphocytic pleural effusion, without a pleural mass on the CT-scan. Rapid diagnosis of these conditions avoids unnecessary invasive examinations and leads to prompt specific treatment.
authors.affiliation: Service de Pneumologie A, Centre de Compétence Maladies Rares Pulmonaires, Hôpital Bichat, Assistance publique-Hôpitaux de Paris, 46, rue Henri-Huchard, 75877 Paris Cedex 18, France. raphael.borie@bch.aphp.fr
authors.forename: R
authors.initials: R
authors.lastname: Borie
authors.forename: J
authors.initials: J
authors.lastname: Cadranel
authors.forename: L
authors.initials: L
authors.lastname: Galicier
authors.forename: L-J
authors.initials: LJ
authors.lastname: Couderc
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000821:virology; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000821:virology; D010802:Phylogeny; D011379:Prognosis; D012514:Sarcoma, Kaposi / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000821:virology