title: Ca²⁺ waves in the heart.
abstract: Ca(2+) waves were probably first observed in the early 1940s. Since then Ca(2+) waves have captured the attention of an eclectic mixture of mathematicians, neuroscientists, muscle physiologists, developmental biologists, and clinical cardiologists. This review discusses the current state of mathematical models of Ca(2+) waves, the normal physiological functions Ca(2+) waves might serve in cardiac cells, as well as how the spatial arrangement of Ca(2+) release channels shape Ca(2+) waves, and we introduce the idea of Ca(2+) phase waves that might provide a useful framework for understanding triggered arrhythmias.
authors.affiliation: Department of Pharmacology, University of California, Davis, USA. ltizu@ucdavis.edu
authors.forename: Leighton T
authors.initials: LT
authors.lastname: Izu
authors.forename: Yuanfang
authors.initials: Y
authors.lastname: Xie
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sato
authors.forename: Tamás
authors.initials: T
authors.lastname: Bányász
authors.forename: Ye
authors.initials: Y
authors.lastname: Chen-Izu
mesh_terms: D001145:Arrhythmias, Cardiac / Q000378:metabolism / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D008962:Models, Theoretical; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D019837:Ryanodine Receptor Calcium Release Channel
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium