title: [Selected aspects of amyloidogenesis].
abstract: Unwanted aggregation of proteins into amyloid fibrils caused by protein misfolding is connected with many human and animal diseases. Mechanism of this process is intensively studied. In the present paper main achievements in this field are described. Some researchers postulate that fibrils are the less harmful species and the most toxic species are the earlier aggregates on the path to mature fibrils..Therefore, monomeric, oligomeric and finally mature fibrils stages of the reaction of amyloidogenesis are reviewed with attention payed to the problem of structural polymorphism of fibrils.
authors.affiliation: Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland. d.stepkowski@nencki.gov.pl
authors.forename: Dariusz
authors.initials: D
authors.lastname: Stepkowski
mesh_terms: D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism*; D000686:Amyloidosis / Q000378:metabolism*; D000818:Animals; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism; D017510:Protein Folding; D057165:Proteostasis Deficiencies / Q000378:metabolism
chemical_list: D000682:Amyloid; D010446:Peptide Fragments