title: Remarkable photocytotoxicity of a novel triazole-linked cationic porphyrin-β-carboline conjugate.
abstract: Employing a click chemistry approach we have synthesized a novel triazole-linked cationic porphyrin-β-carboline conjugate which exhibited remarkable photocytotoxicity against the A549 cancer cell line (IC(50) = 60 nM).
authors.affiliation: Department of Chemistry, Birla Institute of Technology & Science, Pilani-333 031, India. dalipk@bits-pilani.ac.in
authors.forename: Dalip
authors.initials: D
authors.lastname: Kumar
authors.forename: Bhupendra A
authors.initials: BA
authors.lastname: Mishra
authors.forename: K P Chandra
authors.initials: KP
authors.lastname: Shekar
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.forename: Kanako
authors.initials: K
authors.lastname: Akamatsu
authors.forename: Eriko
authors.initials: E
authors.lastname: Kusaka
authors.forename: Takeo
authors.initials: T
authors.lastname: Ito
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008665:Metalloporphyrins / Q000138:chemical synthesis / Q000494:pharmacology*; D010778:Photochemotherapy; D011166:Porphyrins / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002243:Carbolines; D008665:Metalloporphyrins; D011166:Porphyrins; D014230:Triazoles; D015032:Zinc