title: Transplant of an autologous platelet gel prosthesis to fill defects after tumor excision.
abstract: BACKGROUND
  Tumor excision causes disfigurement in the breast. We present our technique for filling the defect with activated platelet gel, thus avoiding the deformity.
  
  
  METHODS
  Between 2006 and 2011, 23 patients (age range, 45-72 years) underwent tumorectomy for breast cancer. After estimating and extracting the volume of blood required, we centrifuged the blood at 1800 rpm for 8 minutes. Later, the middle and lower thirds of the plasma) were separated and activated with CaCl₂ at a ratio of 1/20, forming a gel, which was used to fill the tumorectomy cavity.
  
  
  RESULTS
  Imaging tests (ultrasound, mammography, and magnetic resonance imaging) performed 12 months after surgery revealed scar tissue in the area where the autoprosthesis had been inserted. Magnetic resonance imaging showed no retraction or deformity in the skin silhouette. Histology study after 1 year demonstrated that the platelet gel had been replaced by fibrous scar tissue with dense collagen and the presence of small capillary vessels. Patients recorded high rates of satisfaction.
  
  
  CONCLUSIONS
  This technique maintains the shape and volume of the breast, avoiding deformities and retractions of the nipple areola complex by filling the defect with an autoprosthesis. After 12 months, the autoprosthesis had been replaced by fibrous tissue and dense collagen. Postoperative control was good, and the effectiveness of adjuvant radiotherapy or chemotherapy was not altered. No cases of tumor relapse were recorded. On palpation, consistency and softness were similar to that of breast tissue. The aesthetic results were highly satisfactory.
authors.affiliation: From the *Aesthetic, Plastic and Reconstructive Surgery Department, Hospital Quirón Barcelona, Universitat Internacional de Catalunya; †Obstetrics and Gynecology Department, Hospital Quirón Barcelona; ‡Aesthetic, Plastic and Reconstructive Surgery Department, Seconda Università degli Studi di Napoli; §Pathology Department, Hospital Quirón Barcelona; and ∥Radiology Department, Hospital Quirón Barcelona, Spain.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Serra-Renom
authors.forename: Guillem
authors.initials: G
authors.lastname: Cabero
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Serra-Mestre
authors.forename: Francesco
authors.initials: F
authors.lastname: D'Andrea
authors.forename: Vicente
authors.initials: V
authors.lastname: Marco
authors.forename: Wenceslao
authors.initials: W
authors.lastname: Mayo
mesh_terms: D000368:Aged; D001792:Blood Platelets; D019928:Breast Implantation / Q000379:methods*; D018427:Breast Implants; D001943:Breast Neoplasms / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000601:surgery; D005260:Female; D005782:Gels; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D003557:Phyllodes Tumor / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D005782:Gels