title: Effect of phencyclidine derivatives on anxiety-like behavior using an elevated-plus maze test in mice.
abstract: OBJECTIVE
  The study attempted to investigate the anti-anxiety activities of Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and some of its derivatives (M, F, L, B, S, P) with the elevated-plus maze (EPM) Test.
  
  
  METHODS
  Phencyclidine and its derivatives (M, F, L, B, S, P) were administrated intraperitoneally (i.p.) at a dose of 10 mg/kg to male mice. Anxiety-like behaviors were assessed using the elevated-plus maze test.
  
  
  RESULTS
  EPM results revealed an increase in open arms time spent after applying PCP and M, L, P, and B compounds at the administered dosage. Moreover, an increase in the number of open arm entries was observed with M, P, and B compounds. The P, B and S compounds increased the locomotion of animals, too, which might be considered as the side effect to the compounds.
  
  
  CONCLUSIONS
  Considering the elevated-plus maze results, it was concluded that M and L compounds could be considered as a potential anxiolytic with less side effects due to a probable high electron donation of the methoxy group, as well as the hydrophilic properties of hydroxyl groups on these compounds.
authors.affiliation: Department of Physiology, Faculty of Science, Islamic Azad University, Karaj branch, Karaj, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Hajikhani
authors.forename: Abbas
authors.initials: A
authors.lastname: Ahmadi
authors.forename: Nima
authors.initials: N
authors.lastname: Naderi
authors.forename: Kayvan
authors.initials: K
authors.lastname: Yaghoobi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Shirazizand
authors.forename: Nazereh M
authors.initials: NM
authors.lastname: Rezaee
authors.forename: Babak N
authors.initials: BN
authors.lastname: Niknafs
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy* / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects*; D004195:Disease Models, Animal; D057927:Hydrophobic and Hydrophilic Interactions; D007274:Injections, Intraperitoneal; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D010622:Phencyclidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D014151:Anti-Anxiety Agents; D010622:Phencyclidine