title: Extracapsular spread and FDG PET/CT correlations in oral squamous cell carcinoma.
abstract: The purpose of this study was to evaluate the use of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) to identify extracapsular spread (ECS) with histologic correlations in oral squamous cell carcinoma (OSCC). The medical records of 80 patients who underwent of FDG PET/CT for OSCC before surgery were reviewed. ECS was present in 60% (24/40) dissected necks and in 55% (39/71) of dissected cervical levels. A significant difference was found between the maximum standardized uptake (SUVmax) values of cervical lymph nodes with ECS and without ECS (3.33±1.91 vs. 1.12±1.24, p<0.001). When receiver operating characteristic (ROC) curve analysis and SUVmax values were used to detect ECS, the area under the ROC curve was 0.864±0.045 (p<0.001). At an optimal SUVmax cut-off value of 2.25 the sensitivity and specificity were 85% and 88%, respectively. The presence of ECS and a SUVmax>2.25 had a significant adverse effect on 5-year disease specific survival. A SUV(max)>2.25 was found to be associated with a greater risk of cervical lymph node metastasis in OSCC.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Y H
authors.initials: YH
authors.lastname: Joo
authors.forename: I R
authors.initials: IR
authors.lastname: Yoo
authors.forename: K J
authors.initials: KJ
authors.lastname: Cho
authors.forename: J O
authors.initials: JO
authors.lastname: Park
authors.forename: I C
authors.initials: IC
authors.lastname: Nam
authors.forename: M S
authors.initials: MS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009060:Mouth Floor / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D009062:Mouth Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D009333:Neck; D009361:Neoplasm Invasiveness / Q000000981:diagnostic imaging / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods; D016016:Proportional Hazards Models; D012372:ROC Curve; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods; D014062:Tongue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18