title: Pulmonary hypertension: use of oral drugs in patients with renal insufficiency.
abstract: Pulmonary hypertension (PH) is a progressive, fatal pulmonary circulatory disease that is characterized by elevated pulmonary arterial pressure and secondary right ventricular failure. PH has been reported to be highly prevalent in patients with chronic kidney disease, and especially among end-stage renal disease patients undergoing haemodialysis. However, only few data are available on drug dosage adjustment to renal function for those drugs that are commonly used in the treatment of PH. We reviewed the literature and gathered information, although sparse, to propose guidelines for using these drugs in renal insufficiency patients.
authors.affiliation: Service ICAR, Service de Néphrologie, Groupe Hospitalier Pitié-Salpétrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. sarah.rapuch@psl.aphp.fr
authors.forename: Sarah
authors.initials: S
authors.lastname: Zimner-Rapuch
authors.forename: Sabine
authors.initials: S
authors.lastname: Amet
authors.forename: Nicolas
authors.initials: N
authors.lastname: Janus
authors.forename: Gilbert
authors.initials: G
authors.lastname: Deray
authors.forename: Vincent
authors.initials: V
authors.lastname: Launay-Vacher
mesh_terms: D000284:Administration, Oral; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D001794:Blood Pressure / Q000187:drug effects*; D054796:Drug Dosage Calculations; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D051437:Renal Insufficiency / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents