title: [Epidural labor analgesia and parturient with type 2B von Willebrand disease].
abstract: Type 2B von Willebrand disease (vWD) is an inherited bleeding syndrome resulting from a qualitative abnormality of von Willebrand Factor with an increased affinity for the glycoprotein Ib platelet receptor. Pregnancy increases the severity of this disease by decreasing the platelet count restricting epidural anaesthesia because of adverse risk of spinal bleeding. There is a phenotypic variability of Type 2B vWD depending of the von Willebrand Factor mutation. We report here the strategy we used to administer epidural anaesthesia for a patient with Type 2B vWD resulting from the P1337L mutation of von Willebrand Factor.
authors.affiliation: Service d'anesthésie-réanimation I, hôpital Pellegrin, CHU de Bordeaux, 33076 Bordeaux, France.
authors.forename: J
authors.initials: J
authors.lastname: Lagarrigue
authors.forename: B
authors.initials: B
authors.lastname: Richez
authors.forename: B
authors.initials: B
authors.lastname: Julliac
authors.forename: L
authors.initials: L
authors.lastname: Saltel
authors.forename: P
authors.initials: P
authors.lastname: Nurden
authors.forename: F
authors.initials: F
authors.lastname: Sztark
mesh_terms: D015360:Analgesia, Epidural / Q000009:adverse effects; D016362:Analgesia, Obstetrical / Q000009:adverse effects; D000075202:Contraindications; D005260:Female; D046748:Hematoma, Epidural, Spinal / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D009154:Mutation; D010976:Platelet Count; D019106:Postoperative Hemorrhage / Q000188:drug therapy; D011247:Pregnancy; D055815:Young Adult; D056728:von Willebrand Disease, Type 2 / Q000150:complications* / Q000235:genetics; D014841:von Willebrand Factor / Q000235:genetics
chemical_list: D014841:von Willebrand Factor