title: A versatile and practical method for regioselective synthesis of polysubstituted furanonaphthoquinones.
abstract: An efficient and attractive synthesis of a series of novel poly-functionalized phosphorus zwitterions was achieved via three-component reactions of the corresponding functional nucleophiles, aldehydes, and Bu(3)P in the presence of acidic promoter. These polysubstituted zwitterions could regioselectively undergo further transformations to synthetically important furanonaphthoquinones and related products via the intramolecular Wittig reaction. These methods could have potential application in synthetic and pharmaceutical chemistry for its facilitation and easily accessible commercial materials.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, ROC.
authors.forename: Zong-Ze
authors.initials: ZZ
authors.lastname: Wu
authors.forename: Yeong-Jiunn
authors.initials: YJ
authors.lastname: Jang
authors.forename: Chia-Jui
authors.initials: CJ
authors.lastname: Lee
authors.forename: Yen-Te
authors.initials: YT
authors.lastname: Lee
authors.forename: Wenwei
authors.initials: W
authors.lastname: Lin
mesh_terms: D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry; D010758:Phosphorus / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D005663:Furans; D007477:Ions; D009285:Naphthoquinones; D010758:Phosphorus