title: Assessment of left ventricular myocardial scar in coronary artery disease by a three-dimensional MR imaging technique.
abstract: OBJECTIVE
  To evaluate the feasibility of free-breathing three-dimensional (3D) phase sensitive inversion recovery (PSIR) Turbo FLASH late gadolinium enhancement (LGE) magnetic resonance images (MRI) on left ventricular scar in patients with coronary artery disease (CAD) compared with clinically established breathhold two-dimensional (2D) PSIR Turbo FLASH images.
  
  
  METHODS
  In 58 consecutive patients with confirmed CAD, LGE MRI using the two sequences have been acquired. Image quality was graded on a four-point scale according to the image appearance. Qualitative evaluation including the distribution area and the transmural extent of the scar based on the American Heart Association's (AHA's) 17-segment model was performed in both of 2D and 3D images. The scar volumes were compared quantitatively between 2D and 3D images.
  
  
  RESULTS
  A total of 51 individuals were used for final statistical analysis. No differences were noted in image quality (P = 0.80), scar distribution area (P = 0.17), and scar transmural extent (P = 0.20) between 3D and 2D images. There was strong correlation in scar volume between the 3D and 2D results (r = 0.940; P < 0.001; Y = 0.298 + 1.251X, R(2) = 0.876). But the scar volume derived from 3D images was significantly larger than that derived from 2D images (2D versus 3D, 20.08 ± 9.41 cm(3) versus 25.41 ± 12.57 cm(3) , t = -7.60; P < 0.001). The trend toward a larger scar volume identified by 3D method was indicated through Bland-Altman analysis.
  
  
  CONCLUSIONS
  Free-breathing 3D PSIR Turbo FLASH imaging is another feasible method to identify left ventricular myocardial scar in patients with CAD and detects more scar volume compared with breathhold 2D PSIR Turbo FLASH imaging.
authors.affiliation: Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Yin
authors.forename: Shihua
authors.initials: S
authors.lastname: Zhao
authors.forename: Minjie
authors.initials: M
authors.lastname: Lu
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.forename: Sven
authors.initials: S
authors.lastname: Zuehlsdorff
authors.forename: Huaibing
authors.initials: H
authors.lastname: Cheng
authors.forename: Shiliang
authors.initials: S
authors.lastname: Jiang
authors.forename: Tao
authors.initials: T
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: An
authors.forename: Chuanjian
authors.initials: C
authors.lastname: Lv
authors.forename: Zuoxiang
authors.initials: Z
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D062485:Breath Holding; D002921:Cicatrix / Q000209:etiology / Q000473:pathology*; D003324:Coronary Artery Disease / Q000150:complications / Q000473:pathology*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017682:Myocardial Stunning / Q000209:etiology / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000473:pathology*