title: Modeling external events in the three-level analysis of multiple-baseline across-participants designs: a simulation study.
abstract: In this study, we focus on a three-level meta-analysis for combining data from studies using multiple-baseline across-participants designs. A complicating factor in such designs is that results might be biased if the dependent variable is affected by not explicitly modeled external events, such as the illness of a teacher, an exciting class activity, or the presence of a foreign observer. In multiple-baseline designs, external effects can become apparent if they simultaneously have an effect on the outcome score(s) of the participants within a study. This study presents a method for adjusting the three-level model to external events and evaluates the appropriateness of the modified model. Therefore, we use a simulation study, and we illustrate the new approach with real data sets. The results indicate that ignoring an external event effect results in biased estimates of the treatment effects, especially when there is only a small number of studies and measurement occasions involved. The mean squared error, as well as the standard error and coverage proportion of the effect estimates, is improved with the modified model. Moreover, the adjusted model results in less biased variance estimates. If there is no external event effect, we find no differences in results between the modified and unmodified models.
authors.affiliation: University of Leuven, Leuven, Belgium. mariola.moeyaert@ped.kuleuven.be
authors.forename: Mariola
authors.initials: M
authors.lastname: Moeyaert
authors.forename: Maaike
authors.initials: M
authors.lastname: Ugille
authors.forename: John M
authors.initials: JM
authors.lastname: Ferron
authors.forename: S Natasha
authors.initials: SN
authors.lastname: Beretvas
authors.forename: Wim
authors.initials: W
authors.lastname: Van den Noortgate
mesh_terms: D000704:Analysis of Variance; D015982:Bias; D003626:Data Display; D005260:Female; D006801:Humans; D015233:Models, Statistical; D012107:Research Design; D018401:Sample Size