title: Oral lichen planus: a retrospective study of 633 patients from Bucharest, Romania.
abstract: OBJECTIVE
  In this retrospective study, patients' medical records were reviewed to investigate the profiles of 633 OLP cases in a group of Romania.
  
  
  METHODS
  In this retrospective study, the following clinical data were obtained from the medical charts of patients: gender, age, clinical presentation of OLP, site affected, presence of symptoms, extraoral manifestations of lichen planus, presence of systemic diseases, and history of medications.
  
  
  RESULTS
  Most (78.67%) OLP patients were female and the mean age at presentation was 52 years. The white type of the disease (reticular/papular/plaque lesions) was the main form encountered in this sample (48.97%). Among patients with available hepatitis C virus test results, 9.6% were serum-positive. OLP was associated with gallbladder disease (i.e. cholecystitis, cholelithiasis) in 19% of patients. Six patients (0.95%) developed squamous cell carcinoma at a site with confirmed OLP lesions.
  
  
  CONCLUSIONS
  To the best of our knowledge, no similar study has been conducted in a Romanian population. The present investigation revealed the predominance of OLP among middle-aged white women and the prevalence of bilateral involvement of the buccal mucosa with reticular white lesions. Anti-HCV circulating antibodies were more common in patients with OLP than in the general population and, notably, OLP was associated with gallbladder disease (cholecystitis, cholelithiasis) in 19% of patients.
authors.affiliation: Department of Oral Medicine and Oral Pathology, Faculty of Dental Medicine, Carol Davila University of Bucharest, Calea Plevnei. Nr. 19 sector 1, 010221, Bucharest, Romania. serban.tovaru@gmail.com
authors.forename: Serban
authors.initials: S
authors.lastname: Tovaru
authors.forename: Ioanina
authors.initials: I
authors.lastname: Parlatescu
authors.forename: Carmen
authors.initials: C
authors.lastname: Gheorghe
authors.forename: Mihaela
authors.initials: M
authors.lastname: Tovaru
authors.forename: Mariana
authors.initials: M
authors.lastname: Costache
authors.forename: Andrea
authors.initials: A
authors.lastname: Sardella
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000150:complications / Q000175:diagnosis*; D008297:Male; D012189:Retrospective Studies; D012383:Romania