title: Churg-Strauss syndrome presenting with acute kidney injury in a case of primary focal segmental glomerulosclerosis.
abstract: Churg-Strauss syndrome (CSS) also called allergic granulomatosis and angiitis is a multisystem disorder. Churg-Strauss syndrome is defined as an eosinophil-rich, granulomatous inflammation involving the respiratory tract, along with necrotizing vasculitis affecting small- to medium-sized vessels, and is associated with asthma and eosinophilia. Renal involvement in CSS varies from 26 to 88 % but is usually of mild to moderate stage, and advanced renal failure is uncommon. We encountered an unusual case of 27-year-old man with asthma and primary focal segmental glomerulosclerosis diagnosed as CSS showing myeloperoxidase anti-neutrophil cytoplasmic antibody-associated acute kidney injury with crescentic glomerulonephritis. Patient responded to steroid and cyclophosphamide. Over a follow-up of 2 months, he has no hematuria/eosinophilia and serum creatinine of 2.3 mg/dL has decreased to 1.7 mg/dL.
authors.affiliation: Department of Nephrology and Clinical Transplantation, Institute Of Kidney Diseases and Research Centre, Dr H L Trivedi Institute Of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus, Ahmadabad, 380016, Gujarat, India, drsachinbpatil@yahoo.com.
authors.forename: Sachin B
authors.initials: SB
authors.lastname: Patil
authors.forename: Aruna V
authors.initials: AV
authors.lastname: Vanikar
authors.forename: Manoj R
authors.initials: MR
authors.lastname: Gumber
authors.forename: Vivek B
authors.initials: VB
authors.lastname: Kute
authors.forename: Pankaj R
authors.initials: PR
authors.lastname: Shah
authors.forename: Himanshu V
authors.initials: HV
authors.lastname: Patel
authors.forename: Hargovind L
authors.initials: HL
authors.lastname: Trivedi
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000175:diagnosis; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D008297:Male
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic