title: Gold-catalyzed sequential alkyne activation for the synthesis of 4,6-disubstituted phosphorus 2-pyrones.
abstract: Tandem gold-catalyzed addition of alkynyl phosphonic acid monoethyl esters to terminal alkynes and cyclization were developed for the synthesis of 4,6-disubstituted phosphorus 2-pyrones in one reaction vessel based on the concept of sequential alkyne activation. Alkynyl enol phosphonates were selectively obtained through the gold-catalyzed addition reaction in the presence of a catalytic amount of triethylamine. Also, gold-catalyzed cyclization of alkynyl enol phosphonates was successful in giving a variety of 4,6-disubstituted phosphorus 2-pyrones.
authors.affiliation: Department of Chemistry, Kangwon National University, Chuncheon 200-701, Republic of Korea.
authors.forename: Juntae
authors.initials: J
authors.lastname: Mo
authors.forename: Dongjin
authors.initials: D
authors.lastname: Kang
authors.forename: Dahan
authors.initials: D
authors.lastname: Eom
authors.forename: Sung Hong
authors.initials: SH
authors.lastname: Kim
authors.forename: Phil Ho
authors.initials: PH
authors.lastname: Lee
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D009943:Organophosphorus Compounds; D011753:Pyrones; D006046:Gold