title: Dissemination of a carbapenem-resistant Acinetobacter baumannii strain belonging to international clone II/sequence type 2 and harboring a novel AbaR4-like resistance island in Latvia.
abstract: An outbreak of hospital-acquired Acinetobacter baumannii infections, caused by a bla(OXA-23)-positive carbapenem-resistant strain belonging to international clone II/ST2, was detected in Latvia. The strain was partially equipped with the armA gene and the intI1-aacA4-catB8-aadA1-qacEΔ1 class 1 integron. In addition, the strain carried AbaR25, a novel AbaR4-like resistance island of ~46,500 bp containing structures similar to the previously described AbaR22 and Tn6167 islands. AbaR25 was characterized by the occurrence of a second copy of Tn6022a interrupted by Tn2006 carrying the bla(OXA-23) gene.
authors.affiliation: P Stradins Clinical University Hospital, Riga, Latvia.
authors.forename: Mara
authors.initials: M
authors.lastname: Saule
authors.forename: Ørjan
authors.initials: Ø
authors.lastname: Samuelsen
authors.forename: Uga
authors.initials: U
authors.lastname: Dumpis
authors.forename: Arnfinn
authors.initials: A
authors.lastname: Sundsfjord
authors.forename: Aija
authors.initials: A
authors.lastname: Karlsone
authors.forename: Arta
authors.initials: A
authors.lastname: Balode
authors.forename: Edvins
authors.initials: E
authors.lastname: Miklasevics
authors.forename: Nabil
authors.initials: N
authors.lastname: Karah
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000145:classification / Q000187:drug effects / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015373:Bacterial Typing Techniques; D015780:Carbapenems / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D004251:DNA Transposable Elements; D004196:Disease Outbreaks; D019450:Genes, MDR / Q000235:genetics; D044404:Genomic Islands / Q000235:genetics; D032023:Integrons / Q000235:genetics; D007844:Latvia; D008780:Methyltransferases / Q000235:genetics; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D004251:DNA Transposable Elements; D008780:Methyltransferases; D001618:beta-Lactamases