title: Lipase-catalyzed synthesis and characterization of polymers by cyclodextrin as support architecture.
abstract: Diesters and diols were successfully converted into aliphatic polyesters by enzymatic lipase Candida sp.99-125 catalysis, with β-cyclodextrin acting as supporting architecture (in a similar way as chaperone proteins). No organic solvents were used. The polytransesterification was a much greener process, being solvent-free and without metal residues. Lipase Candida sp.99-125 showed a high catalytic activity for bulkpolymerization of diesters and diols with various numbers of methylene groups in their chains. β-Cyclodextrin encircled the linear polymer chain and maintained the chain in a proper configuration to avoid its coagulation. Lipase initiated the polymerization and β-cyclodextrin threaded onto the polymer chain to control the structure for producing high molecular weight polyesters. From a combination of diesters and diols, polyesters with a high molecular weight of 62,100 Da were obtained at 70 °C. The corresponding polyesters showed an excellent thermal stability till 350 °C and had a strong ability to crystallize with up to 72% crystallinity, contributing to their high storage modulus.
authors.affiliation: The Biorefinery Research and Engineering Center of the Ministry of Education, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Tianwei
authors.initials: T
authors.lastname: Tan
authors.forename: Biqiang
authors.initials: B
authors.lastname: Chen
mesh_terms: D000438:Alcohols / Q000737:chemistry; D002175:Candida / Q000737:chemistry / Q000378:metabolism; D002384:Catalysis; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry; D008049:Lipase / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: D000438:Alcohols; D003505:Cyclodextrins; D011091:Polyesters; D011108:Polymers; D012997:Solvents; D008049:Lipase