title: MicroRNAs in atherosclerosis.
abstract: MicroRNAs are endogenously expressed small noncoding RNAs that regulate gene expression at the post-transcriptional level. MicroRNAs have emerged as key regulators of several physiological and pathophysiological processes in the cardiovascular system. Aberrant expression of microRNAs has been implicated in the pathophysiological processes underlying the development of atherosclerosis and cardiovascular disease, including change in endothelial function, vascular smooth muscle cell proliferation and migration, macrophage function, and foam cell formation. In this review, we summarize the recent data showing the roles of microRNAs in cell studies, studies on atherosclerotic mice, and human studies.
authors.affiliation: Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Ku-Chung
authors.initials: KC
authors.lastname: Chen
authors.forename: Suh-Hang Hank
authors.initials: SH
authors.lastname: Juo
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000235:genetics*; D015415:Biomarkers / Q000378:metabolism; D002319:Cardiovascular System / Q000503:physiopathology; D002465:Cell Movement; D049109:Cell Proliferation; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000166:cytology; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000166:cytology; D012323:RNA Processing, Post-Transcriptional; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D035683:MicroRNAs