title: Three-component access to pyrroles promoted by the CAN-silver nitrate system under high-speed vibration milling conditions: a generalization of the Hantzsch pyrrole synthesis.
abstract: A sequential multicomponent process involving the high-speed vibration milling of ketones with N-iodosuccinimide and p-toluenesulfonic acid, followed by addition of a mixture of primary amines, β-dicarbonyl compounds, cerium(IV) ammonium nitrate and silver nitrate afforded polysubstituted, functionalized pyrroles. This one-pot, solid-state process can be considered as the coupling of an α-iodoketone preparation with a general version of the classical Hantzsch pyrrole synthesis.
authors.affiliation: Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Estévez
authors.forename: Mercedes
authors.initials: M
authors.lastname: Villacampa
authors.forename: J Carlos
authors.initials: JC
authors.lastname: Menéndez
mesh_terms: D000588:Amines / Q000737:chemistry; D001557:Benzenesulfonates / Q000737:chemistry; D002586:Cesium / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D012835:Silver Nitrate / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry; D014732:Vibration
chemical_list: D000588:Amines; D001557:Benzenesulfonates; D007659:Ketones; D011758:Pyrroles; D013388:Succinimides; D002586:Cesium; C008155:N-iodosuccinimide; D012835:Silver Nitrate; C029501:4-toluenesulfonic acid