title: A 62-year-old female with an intranasal mass extending into the lamina cribrosa.
abstract: Malignant tumors with neuroendocrine differentiation of the nasal cavity include neuroendocrine carcinoma, small cell undifferentiated carcinoma, olfactory neuroblastoma (esthesioneuroblastoma), and sinonasal undifferentiated carcinoma (SNUC). The rarity of these tumors and overlapping clinical, histological and immunohistochemical findings make the correct diagnosis difficult. However accurate diagnosis is critical for therapy and the outcome differs significantly between these entities. Here we describe the case of a 62-year-old woman with an intranasal tumor extending into the adjacent anatomical compartments and with infiltration of the meninges. The suspected preoperative diagnosis was olfactory neuroblastoma. Histological and immunohistochemical analysis showed a lobulated tumor with neuroendocrine differentiation and we ultimately diagnosed the process as a SNUC. In this report, we discuss the differential diagnosis at hand and present histological findings found in the specimen indicating that the process originated from local glands present in the nasal mucosa.
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Hofer
authors.forename: Jochen
authors.initials: J
authors.lastname: Rohlfs
authors.forename: Afshin
authors.initials: A
authors.lastname: Teymoortash
authors.forename: Axel
authors.initials: A
authors.lastname: Pagenstecher
mesh_terms: D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology*; D002277:Carcinoma / Q000175:diagnosis* / Q000601:surgery; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008444:Maxillary Sinus Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis* / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D019006:Neural Cell Adhesion Molecules; D009418:S100 Proteins; D016708:Synaptophysin