title: Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae.
abstract: Chronological aging of budding yeast cells results in a reduction in subsequent replicative life span through unknown mechanisms. Here we show that dietary restriction during chronological aging delays the reduction in subsequent replicative life span up to at least 23days of chronological age. We further show that among the viable portion of the control population aged 26days, individual cells with the lowest mitochondrial membrane potential have the longest subsequent replicative lifespan. These observations demonstrate that dietary restriction modulates a common molecular mechanism linking chronological and replicative aging in yeast and indicate a critical role for mitochondrial function in this process.
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA.
authors.forename: Joe R
authors.initials: JR
authors.lastname: Delaney
authors.forename: Christopher
authors.initials: C
authors.lastname: Murakami
authors.forename: Annie
authors.initials: A
authors.lastname: Chou
authors.forename: Daniel
authors.initials: D
authors.lastname: Carr
authors.forename: Jennifer
authors.initials: J
authors.lastname: Schleit
authors.forename: George L
authors.initials: GL
authors.lastname: Sutphin
authors.forename: Elroy H
authors.initials: EH
authors.lastname: An
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Castanza
authors.forename: Marissa
authors.initials: M
authors.lastname: Fletcher
authors.forename: Sarani
authors.initials: S
authors.lastname: Goswami
authors.forename: Sean
authors.initials: S
authors.lastname: Higgins
authors.forename: Mollie
authors.initials: M
authors.lastname: Holmberg
authors.forename: Jessica
authors.initials: J
authors.lastname: Hui
authors.forename: Monika
authors.initials: M
authors.lastname: Jelic
authors.forename: Ki-Soo
authors.initials: KS
authors.lastname: Jeong
authors.forename: Jin R
authors.initials: JR
authors.lastname: Kim
authors.forename: Shannon
authors.initials: S
authors.lastname: Klum
authors.forename: Eric
authors.initials: E
authors.lastname: Liao
authors.forename: Michael S
authors.initials: MS
authors.lastname: Lin
authors.forename: Winston
authors.initials: W
authors.lastname: Lo
authors.forename: Hillary
authors.initials: H
authors.lastname: Miller
authors.forename: Richard
authors.initials: R
authors.lastname: Moller
authors.forename: Zhao J
authors.initials: ZJ
authors.lastname: Peng
authors.forename: Tom
authors.initials: T
authors.lastname: Pollard
authors.forename: Prarthana
authors.initials: P
authors.lastname: Pradeep
authors.forename: Dillon
authors.initials: D
authors.lastname: Pruett
authors.forename: Dilreet
authors.initials: D
authors.lastname: Rai
authors.forename: Vanessa
authors.initials: V
authors.lastname: Ros
authors.forename: Alex
authors.initials: A
authors.lastname: Schuster
authors.forename: Minnie
authors.initials: M
authors.lastname: Singh
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Spector
authors.forename: Helen Vander
authors.initials: HV
authors.lastname: Wende
authors.forename: Adrienne M
authors.initials: AM
authors.lastname: Wang
authors.forename: Brian M
authors.initials: BM
authors.lastname: Wasko
authors.forename: Brady
authors.initials: B
authors.lastname: Olsen
authors.forename: Matt
authors.initials: M
authors.lastname: Kaeberlein
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D002455:Cell Division / Q000502:physiology; D046508:Culture Techniques / Q000379:methods; D005434:Flow Cytometry; D005947:Glucose / Q000378:metabolism; D053078:Membrane Potential, Mitochondrial / Q000502:physiology; D008928:Mitochondria / Q000502:physiology*; D012098:Reproduction / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000254:growth & development* / Q000378:metabolism / Q000502:physiology; D013997:Time Factors
chemical_list: D005947:Glucose