title: NY-ESO-1 expression in sarcomas: A diagnostic marker and immunotherapy target.
abstract: NY-ESO-1 (CTAG 1B) is highly expressed in the majority of synovial sarcomas and myxoid/round cell liposarcomas as well as in a subset of melanomas, but only rarely in other mesenchymal tumors. This points to a potential for using NY-ESO-1 in the differential diagnosis of these lesions. Furthermore, promising results have been obtained in clinical trials testing NY-ESO-1-targeted immunotherapy in subsets of melanoma and synovial sarcoma patients.
authors.affiliation: Laboratory of Pathology; National Cancer Institute; NIH; Bethesda, MD USA.
authors.forename: Jin-Ping
authors.initials: JP
authors.lastname: Lai
authors.forename: Avi Z
authors.initials: AZ
authors.lastname: Rosenberg
authors.forename: Markku M
authors.initials: MM
authors.lastname: Miettinen
authors.forename: Chyi-Chia R
authors.initials: CC
authors.lastname: Lee