title: 2-Substituted 3-arylindoles through palladium-catalyzed arylative cyclization of 2-alkynyltrifluoroacetanilides with arylboronic acids under oxidative conditions.
abstract: Free NH 2-substituted 3-arylindoles have been prepared usually in good to high yields through the palladium-catalyzed reaction of readily available 2-alkynyltrifluoroacetanilides with arylboronic acids under oxidative conditions. The reaction tolerates a variety of useful functional groups both in the arylboronic acid and in the alkyne, including chloro, formyl, and ester groups.
authors.affiliation: Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi di L'Aquila, Via Vetoio, 67010 Coppito, L'Aquila, Italy. antonio.arcadi@univaq.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Arcadi
authors.forename: Sandro
authors.initials: S
authors.lastname: Cacchi
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Fabrizi
authors.forename: Antonella
authors.initials: A
authors.lastname: Goggiamani
authors.forename: Antonia
authors.initials: A
authors.lastname: Iazzetti
authors.forename: Fabio
authors.initials: F
authors.lastname: Marinelli
mesh_terms: D000083:Acetanilides / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D000083:Acetanilides; D001897:Boronic Acids; D007211:Indoles; C009551:trifluoroacetanilide; D010165:Palladium