title: Detection of myocardial ischemia in diabetic patients: the limitations of myocardial perfusion imaging.
abstract: In the study of 286 patients with suspected coronary artery disease and recent exercise single photon emission computed tomography (SPECT) test, we performed coronary angiography with coronary fractional flow reserve (FFR) measurement and tested the differences between diabetic (103) and non-diabetic (183) patients in ischemia detection by this two methods. The diabetic patients had a higher prevalence of hypertension, higher BMI and cholesterol levels, as well as longer duration of hospitalization than non-diabetic patients. There was no difference found between groups according to the exercise SPECT test, but, there were significantly more negative results in the non-diabetic group than in the diabetic group according to the FFR test, also, the percentage of stenosis was higher in diabetic patients. The concordance between the two methods was found, it was fair in diabetic patients (kappa = 0.25, 95% C.I. 0.06-0.45) and moderate in non-diabetic patients (kappa = 0.49, 95% C.I. 0.36-0.62).
authors.affiliation: University of Rijeka, Rijeka University Hospital Center, Department of Cardiology, Rijeka, Croatia. tjakljevic@inet.hr
authors.forename: Tomislav
authors.initials: T
authors.lastname: Jakljević
authors.forename: Alen
authors.initials: A
authors.lastname: Ruzić
authors.forename: Ksenija
authors.initials: K
authors.lastname: Bazdarić
authors.forename: Luka
authors.initials: L
authors.lastname: Zaputović
authors.forename: Zarko
authors.initials: Z
authors.lastname: Mavrić
authors.forename: Stephane
authors.initials: S
authors.lastname: Champagne
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Teiger
mesh_terms: D000368:Aged; D017023:Coronary Angiography / Q000379:methods / Q000592:standards; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005080:Exercise Test / Q000379:methods / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000453:epidemiology; D055414:Myocardial Perfusion Imaging / Q000379:methods* / Q000592:standards; D015995:Prevalence; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods / Q000592:standards