title: Analysis of critical molecules and signaling pathways in osteoarthritis             and rheumatoid arthritis.
abstract: Osteoarthritis (OA) and rheumatoid arthritis (RA) are the most prevalent forms of arthritis in the elderly. This study aimed to explore the molecular mechanisms of these diseases and identify underlying therapeutic targets. Using GSE1919 microarray data sets downloaded from the Gene Expression Omnibus database, we screened differentially expressed genes (DEGs) in OA and RA cells. The underlying molecular mechanisms of these crucial genes were investigated by Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. Small molecule expression and SNP analysis were also conducted by searching CMap and dbSNP databases. More than 320 genes changed in the arthritic cells and there were only 196 DEGs between OA and RA. OA and RA activated the classic mitogen-activated protein kinase signaling pathway, insulin signaling pathway, antigen processing and presentation and intestinal immune network for IgA production. Graft-versus-host disease and autoimmune thyroid disease-related pathways were also activated in OA and RA. Parthenolide and alsterpaullone may be treatments for OA and RA and insulin-like growth factor 1, collagen α2(I) chain and special AT-rich sequence-binding protein 2 may be critical SNP molecules in arthritis. Our findings shed new light on the common molecular mechanisms of OA and RA and may provide theoretical support for further clinical therapeutic studies.
authors.affiliation: Department of Orthopaedics, Fengxian Central Hospital, Shanghai                     201400, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xue
authors.forename: Changqing
authors.initials: C
authors.lastname: Zhang
authors.forename: Zhimin
authors.initials: Z
authors.lastname: He
authors.forename: Liang
authors.initials: L
authors.lastname: Ding
authors.forename: Haijun
authors.initials: H
authors.lastname: Xiao
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D001327:Autoimmune Diseases / Q000378:metabolism / Q000473:pathology; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D006086:Graft vs Host Disease / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D010003:Osteoarthritis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D015398:Signal Transduction / Q000235:genetics*; D013583:Synovial Membrane / Q000378:metabolism
chemical_list: D024042:Collagen Type I; D004268:DNA-Binding Proteins; D007334:Insulin-Like Growth Factor I; D020928:Mitogen-Activated Protein Kinases