title: Early-onset acquired myasthenia gravis secondary to anti-muscle-specific kinase autoantibodies.
abstract: Autoimmune myasthenia gravis is rarely seen during infancy. Similar to adults, 85% to 90% of generalized pediatric myasthenia gravis cases have acetylcholine receptor antibodies. Approximately 30% of the remaining cases have antibodies against muscle-specific kinase. Information on the clinical course, treatment alternatives, and prognosis of pediatric muscle-specific kinase antibody-positive myasthenia gravis is limited because of the small number of cases. Here, we present a 14-month-old girl with muscle-specific kinase antibody-positive myasthenia gravis as one of the youngest patients described so far in the literature.
authors.affiliation: 1Department of Pediatrics, Division of Child Neurology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Sanem
authors.initials: S
authors.lastname: Yilmaz
authors.forename: Sarenur
authors.initials: S
authors.lastname: Gokben
authors.forename: Gul
authors.initials: G
authors.lastname: Serdaroglu
authors.forename: Ayfer
authors.initials: A
authors.lastname: Akcay
mesh_terms: D001323:Autoantibodies / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D004576:Electromyography; D005260:Female; D006801:Humans; D007223:Infant; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D011729:Pyridostigmine Bromide / Q000627:therapeutic use; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology*; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D001323:Autoantibodies; D002800:Cholinesterase Inhibitors; D020794:Receptor Protein-Tyrosine Kinases; D011729:Pyridostigmine Bromide