title: A peptide nanofibrous indicator for eye-detectable cancer cell identification.
abstract: A unique peptide nanofibrous indicator (NFI) is fabricated by mixing a borono-peptide with alizarin red S, followed by subsequent binding and self-assembly. The NFI thus obtained exhibits an intense response to sialyl Lewis X tetrasaccharide, which is overexpressed in human hepatocellular carcinoma cell lines. Importantly, this NFI has the capability of specifically recognizing human hepatocellular liver carcinoma (HepG2) cells through the eye-detectable color change resulting from strong binding-induced displacement. This novel technique for cancer cell identification through direct unaided eye judgment will open up an innovative platform for cancer cell detection.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Chen
authors.forename: Xiao-Ding
authors.initials: XD
authors.lastname: Xu
authors.forename: Ya
authors.initials: Y
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.forename: Hui-Zhen
authors.initials: HZ
authors.lastname: Jia
authors.forename: Han
authors.initials: H
authors.lastname: Cheng
authors.forename: Chih-Chang
authors.initials: CC
authors.lastname: Chu
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D002522:Chlorocebus aethiops; D003116:Color; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis*; D008969:Molecular Sequence Data; D057139:Nanofibers; D010455:Peptides / Q000737:chemistry*; D014785:Vision, Ocular
chemical_list: D010455:Peptides