title: Rhabdomyolysis secondary to influenza A H1N1 vaccine resulting in acute kidney injury.
abstract: Influenza A infection has been described as a major viral cause of infection-induced rhabdomyolysis, but to date, only one reported case was described as having been induced by influenza vaccine. We describe a case of a man who had been using statins and developed rhabdomyolysis the day after influenza A H1N1 vaccination. A 58-year-old man was admitted at the emergency room complaining of impaired gait. The patient reported receiving influenza A H1N1 vaccine 5 days prior to the admission, with symptoms beginning the day after the inoculation. He reported ascending weakness, intense myalgia in the lower back, upper and lower limbs. The admission laboratory tests showed serum creatine phosphokinase: 7600 IU/L, creatinine: 3.0 mg/dL, urea: 185 mg/dL, aspartate aminotransferase: 592 IU/L, alanine aminotransferase: 630 IU/L, potassium: 5.4 mEq/L, lactate dehydrogenase: 2828 IU/L. Despite intravenous fluid therapy, the patient still persisted with oliguria and urinary output of 0.17 ml/kg/h. Hemodialysis was initiated and renal function recovery was observed after two weeks. The patient was hemodynamically stable and asymptomatic at hospital discharge. This is a rare side effect of influenza A H1N1 vaccine. Physicians should advise patients to seek medical care when muscle symptoms are present and consider the possibility of rhabdomyolysis due to vaccination. Trials are required to better define the incidence of this important side effect.
authors.affiliation: School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
authors.forename: Rodrigo Barbosa
authors.initials: RB
authors.lastname: Callado
authors.forename: Tassia Gabrielle Ponte
authors.initials: TG
authors.lastname: Carneiro
authors.forename: Camille Carneiro da Cunha
authors.initials: CC
authors.lastname: Parahyba
authors.forename: Neiberg de Alcantara
authors.initials: Nde A
authors.lastname: Lima
authors.forename: Geraldo Bezerra
authors.initials: GB
authors.lastname: da Silva Junior
authors.forename: Elizabeth de Francesco
authors.initials: Ede F
authors.lastname: Daher
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects*; D007251:Influenza, Human / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012206:Rhabdomyolysis / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000821:virology
chemical_list: D007252:Influenza Vaccines