title: SDF-1alpha G801A polymorphism in Southern Iranian patients with colorectal and gastric cancers.
abstract: BACKGROUND
  A single nucleotide polymorphism (SNP) in the stromal cell-derived factor-1 (SDF-1) gene at position 801 (G>A) is associated with susceptibility to certain tumors. This study aimed to investigate an association between this SNP and colorectal and gastric cancers in an Iranian population.
  
  
  METHODS
  Genotype and allele frequencies of SDF-1 801 G>A were assessed using polymerase chain reaction-restriction fragment length polymorphism in 109 patients with colorectal cancer, 124 with gastric cancer, and 262 normal control volunteers.
  
  
  RESULTS
  No statistically significant difference was observed in the frequencies of genotypes and alleles between patients and controls (p > 0.05).
  
  
  CONCLUSIONS
  SDF-1 gene polymorphism at position 801 (G>A) was not associated with colorectal and gastric cancers in Southern Iranian patients.
authors.affiliation: Shiraz Institute for Cancer Research, Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Razmkhah
authors.forename: Abbas
authors.initials: A
authors.lastname: Ghaderi
mesh_terms: D000483:Alleles; D054377:Chemokine CXCL12 / Q000235:genetics* / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology
chemical_list: D054377:Chemokine CXCL12