title: Pustular-type drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms due to carbamazepine with systemic muscle involvement.
abstract: Drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe reaction usually associated with maculopapular eruptions and systemic involvement. Here we report the first case, to our knowledge, of DIHS/DRESS due to carbamazepine with acute generalized pustular bacterid-like (AGPB-like) eruptions and skeletal muscle involvement. Reviewing our case and the published work, we discuss pustular-type DIHS/DRESS which, in most cases, involves acute generalized exanthematous pustulosis (AGEP)-like skin eruptions in response to carbamazepine. Pustular eruptions may appear in relatively few cases of DIHS/DRESS, in particular, when the causative drug is carbamazepine and, even in cases of intractable pustular bacterid-like eruptions, a reaction to a drug should be suspected. Skeletal muscle involvement may be associated with DIHS/DRESS as one of its systemic manifestations.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Oita University, Yufu City, Japan.
authors.forename: Haruna
authors.initials: H
authors.lastname: Matsuda
authors.forename: Kanami
authors.initials: K
authors.lastname: Saito
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Takayanagi
authors.forename: Toshio
authors.initials: T
authors.lastname: Okazaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Kashima
authors.forename: Kazushi
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kai
authors.forename: Naoko
authors.initials: N
authors.lastname: Takeo
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hatano
authors.forename: Osamu
authors.initials: O
authors.lastname: Okamoto
authors.forename: Sakuhei
authors.initials: S
authors.lastname: Fujiwara
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000150:complications / Q000209:etiology*; D004802:Eosinophilia / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine