title: [Expressions and significances of CD147, OPN and MMP-2 in oral squamous cell carcinoma].
abstract: OBJECTIVE
  To evaluate the expressions and significances of CD147, OPN and MMP-2 in oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  The expressions of CD147, OPN and MMP-2 were detected by immunohistochemical method (SP) in 35 cases of ()SCC. The relationships between the expressions of CD147, OPN and MMP-2 and clinic histopathologic parameters of OSCC were analyzed.
  
  
  RESULTS
  The expression rates of CD147, OPN and MMP-2 in OSCC tissues were 65.71%, 71.43% and 68.57% respectively. The expressions of CD147, OPN and MMP-2 were positively correlated with tumor histopathologic type, clinical stage and lymph node metastasis (P < 0.05), but not correlated with age, gender and the location of tumor (P > 0.05). The positive correlations were found among the expressions of CD147, OPN and MMP-2 (MMP-2 and CD147, r = 0. 653; MMP-2 and OPN, r = 0.540; CD147 and OPN, r = 0.381; P < 0.05).
  
  
  CONCLUSIONS
  The expressions of CD147, OPN and MMP-2 increase in OSCC and may be the potential predictor of the malignant degree of OSCC.
authors.affiliation: West China School of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Man
authors.forename: Shu-Ming
authors.initials: SM
authors.lastname: Ma
authors.forename: Shu-Wen
authors.initials: SW
authors.lastname: Cao
authors.forename: Dong-Wen
authors.initials: DW
authors.lastname: Li
mesh_terms: D000368:Aged; D051926:Basigin / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D009367:Neoplasm Staging; D053495:Osteopontin / Q000378:metabolism*
chemical_list: C497886:BSG protein, human; C506895:SPP1 protein, human; D053495:Osteopontin; D051926:Basigin; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2