title: One-pot sequential organocatalysis: highly stereoselective synthesis of trisubstituted cyclohexanols.
abstract: A highly diastereoselective (d.r. >99:1) and enantioselective (ee value up to 96%) synthesis of trisubstituted cyclohexanols was achieved by using a one-pot sequential organocatalysis that involved a quinidine thiourea-catalyzed tandem Henry-Michael reaction between nitromethane and 7-oxo-hept-5-en-1-als followed by a tetramethyl guanidine (TMG)-catalyzed tandem retro-Henry-Henry reaction on the reaction products of the tandem Henry-Michael reaction. Through a mechanistic study, it has also been demonstrated that similar results may also be achieved with this one-pot sequential organocatalysis by using the racemic Henry product as the substrate.
authors.affiliation: Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.
authors.forename: Qipu
authors.initials: Q
authors.lastname: Dai
authors.forename: Hadi
authors.initials: H
authors.lastname: Arman
authors.forename: John Cong-Gui
authors.initials: JC
authors.lastname: Zhao