title: A prodrug nanoassembly entrapping drugs as a tumor-targeted delivery system.
abstract: We presented here a targeted drug delivery system, biotinylated polyethylene glycol prodrug loading with free drugs (doxorubicin or camptothecin), which showed high drug loading capacity and superior targeted therapeutic efficacy for cancerous cells.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, PR China.
authors.forename: Zhefan
authors.initials: Z
authors.lastname: Yuan
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Yi
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Sixue
authors.initials: S
authors.lastname: Cheng
authors.forename: Renxi
authors.initials: R
authors.lastname: Zhuo
authors.forename: Feng
authors.initials: F
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D019921:Biotinylation; D019556:COS Cells; D002166:Camptothecin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D011092:Polyethylene Glycols / Q000737:chemistry; D011355:Prodrugs / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011355:Prodrugs; D011092:Polyethylene Glycols; D004317:Doxorubicin; D002166:Camptothecin