title: Nerve growth factor-potentiating benzofuran derivatives from the medicinal fungus Phellinus ribis.
abstract: Four new benzofuran derivatives, ribisin A (1), ribisin B (2), ribisin C (3), and ribisin D (4), were isolated from the MeOH extract of the fruiting bodies of Phellinus ribis. Their structures including their absolute configurations were determined by NMR and CD exciton chirality methods. Compounds 1-4 were found to promote neurite outgrowth in NGF-mediated PC12 cells at concentrations ranging from 1 to 30 μM. The structure-activity relationships of these compounds are also discussed.
authors.affiliation: Tokushima Bunri University, Tokushima 770-8514, Japan.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Liu
authors.forename: Miwa
authors.initials: M
authors.lastname: Kubo
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Fukuyama
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002681:China; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells / Q000187:drug effects; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D001572:Benzofurans; D009414:Nerve Growth Factors