title: Baseline serum TARC levels predict therapy outcome in patients with Hodgkin lymphoma.
abstract: Hodgkin lymphoma (HL) has become one of the best curable cancers. However, better biomarkers are needed for outcome prediction that would allow protecting patients from over- or under-dosing of treatment. Thymus and activation-regulated chemokine/CCL17 (TARC) is highly and specifically elevated in this disease and has been proposed as possible biomarker in HL patients. In this study, we show that pretreatment TARC levels were associated with established clinical risk factors and predictive for response to treatment in a large cohort of HL patients treated in clinical trials by the German Hodgkin Study Group. Moreover, TARC levels also significantly contributed to a novel multivariate model predicting treatment response. These data clearly suggest an important role for this chemokine as biomarker in HL.
authors.affiliation: Department of Internal Medicine I, Laboratory for Immunotherapy, University Hospital Cologne, Cologne, Germany.
authors.forename: Maike
authors.initials: M
authors.lastname: Sauer
authors.forename: Annette
authors.initials: A
authors.lastname: Plütschow
authors.forename: Ron D
authors.initials: RD
authors.lastname: Jachimowicz
authors.forename: Dominik
authors.initials: D
authors.lastname: Kleefisch
authors.forename: Katrin S
authors.initials: KS
authors.lastname: Reiners
authors.forename: Sabine
authors.initials: S
authors.lastname: Ponader
authors.forename: Andreas
authors.initials: A
authors.lastname: Engert
authors.forename: Elke Pogge
authors.initials: EP
authors.lastname: von Strandmann
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D054414:Chemokine CCL17 / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D005858:Germany; D006689:Hodgkin Disease / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; C106230:CCL17 protein, human; D054414:Chemokine CCL17