title: Orthotopic heart transplant facilitated autologous hematopoietic stem cell transplantation in light-chain amyloidosis.
abstract: Initial manifestations of light-chain amyloidosis (AL) are variable and often result in missed or delayed diagnosis. Survival in AL patients depends mainly on the severity of cardiac involvement. Dominant stage-III cardiac involvement due to primary systemic amyloidosis precludes effective AL treatment and is associated with an average survival of only 3-4 months. The following paper discusses the benefits of orthotopic heart transplantation and autologous hematopoietic stem cell transplantation to improve survival in patients with progressive cardiac AL.
authors.affiliation: Baylor College of Medicine and The Methodist Hospital, Houston, TX, USA.
authors.forename: Rammurti T
authors.initials: RT
authors.lastname: Kamble
mesh_terms: D000686:Amyloidosis / Q000378:metabolism / Q000601:surgery*; D001706:Biopsy; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D002675:Child, Preschool; D005260:Female; D016027:Heart Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology; D014182:Transplantation, Autologous