title: Validity and reliability of Persian version of Modified Fatigue Impact Scale (MFIS) questionnaire in Iranian patients with multiple sclerosis.
abstract: OBJECTIVE
  To determine the validity and reliability of the Persian version of the Modified Fatigue Impact Scale (MFIS) questionnaire for Iranian patients with multiple sclerosis (MS).
  
  
  METHODS
  One hundred and twenty patients with MS and 75 age-matched healthy controls were enrolled. Participants were asked to answer the valid and reliable Persian version of the Beck depression inventory (BDI), Fatigue Severity Scale (FSS) and translated MFIS questionnaires. Twenty cases filed the questionnaire two weeks later to assess reliability. The intra-class correlation coefficient (ICC), Cronbach's alpha and multiple regression analysis were used.
  
  
  RESULTS
  The total MFIS score and subscale scores differed significantly between the patients with MS and the healthy controls. The ICCs and Cronbach's alpha values were also outstandingly high. There was a significant correlation between the FSS and MFIS scores in patients (r = 0.69, p < 0.001). Also, a significant correlation was investigated between the scores of the BDI and the MFIS (r = 0.68, p < 0.001). Multiple linear regression analysis between the MFIS as a dependent variable and Expanded Disability Status Scale (EDSS), BDI and disease duration as independent variables showed that the BDI and EDSS are dependent predictors of the MFIS.
  
  
  CONCLUSIONS
  The results of this study indicate that the Persian version of MFIS can be regarded as a valid and reliable scale for assessing fatigue in Iranian patients with MS.
  
  
  CONCLUSIONS
  Fatigue is one of the most common, disabling and troublesome complaints of individuals with MS. Different factors such as depression and physical disability are considered to play an important role in MS-related fatigue. Fatigue evaluation by means of a valid and reliable instrument is important in individuals with MS. Persian version of MFIS provides a valid and reliable instrument for fatigue evaluation.
authors.affiliation: Department of Neurology, Brain and Spinal Injury Research Center, MS Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Ghajarzadeh
authors.forename: Rozita
authors.initials: R
authors.lastname: Jalilian
authors.forename: Ghazaleh
authors.initials: G
authors.lastname: Eskandari
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ali Sahraian
authors.forename: Amir
authors.initials: A
authors.lastname: Reza Azimi
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003863:Depression / Q000175:diagnosis* / Q000209:etiology; D004185:Disability Evaluation; D005221:Fatigue / Q000145:classification / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis / Q000208:ethnology; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics / Q000295:instrumentation / Q000592:standards*; D012044:Regression Analysis; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires / Q000592:standards*