title: Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy.
abstract: Recent developments in near-infrared spectroscopy (NIRS) have enabled the non-invasive elucidation of the neurobiological underpinnings of psychiatric disorders. Functional neuroimaging studies in human patients have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of obsessive-compulsive disorder (OCD). Here we used NIRS to investigate neurobiological function in 12 patients with OCD and 12 age- and sex-matched, healthy control subjects. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 s, during performance of a Stroop color-word task, using 24-channel NIRS. Oxy-Hb changes in the prefrontal cortex of the OCD group were significantly smaller than those in the control group, especially in the left lateral prefrontal cortex. These results suggest that patients with OCD have reduced prefrontal hemodynamic responses as measured by NIRS.
authors.affiliation: Department of Psychiatry, Nara Medical University, Nara 634-8522, Japan. k602z6y0513@gmail.com
authors.forename: Koji
authors.initials: K
authors.lastname: Okada
authors.forename: Toyosaku
authors.initials: T
authors.lastname: Ota
authors.forename: Junzo
authors.initials: J
authors.lastname: Iida
authors.forename: Naoko
authors.initials: N
authors.lastname: Kishimoto
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D000328:Adult; D000367:Age Factors; D001810:Blood Volume / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000378:metabolism* / Q000523:psychology; D010108:Oxyhemoglobins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000098:blood supply / Q000378:metabolism*; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D057190:Stroop Test; D055815:Young Adult
chemical_list: D010108:Oxyhemoglobins