title: Serum paraoxonase, arylesterase activity, and oxidative status in patients with nasal polyp.
abstract: The aim of this study was to investigate serum paraoxonase (PON) and arylesterase (ARE) activities, the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in the patient with nasal polyp (NP) and control group to confirm the link between oxidative stress and NP. In this prospective study, 32 patients with NP (22 males and 10 females) and 29 healthy controls (19 males and 10 females) were enrolled. Preoperative serum levels of PON, ARE, TAS, and TOS were determined, and OSI was calculated. Serum PON activity, ARE activity, and TAS tend to be decreased in patients with NP compared to healthy controls (P < 0.0001). TOS and OSI levels were significantly higher in the NP patients than in the healthy controls (P < 0.01). Furthermore, there was established positive correlation between serum PON activity and serum ARE activity in patients with NP (r = 0.454; P = 0.009). Our results support the belief that altered PON and ARE activity may be involved in the pathogenesis of NP. Increased TOS and OSI, and decreased TAS indicated that NP is the pathologic consequence of oxidative stress.
authors.affiliation: Department of Otolaryngology, Tianjin Medical University General Hospital, Tianjin 300052, People's Republic of China.
authors.forename: Wenwei
authors.initials: W
authors.lastname: Hao
authors.forename: Yongping
authors.initials: Y
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Meng
authors.forename: Changbao
authors.initials: C
authors.lastname: Ni
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Huifang
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D009298:Nasal Polyps / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011446:Prospective Studies
chemical_list: D000975:Antioxidants; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase