title: Assessing the combined performance of texture and morphological parameters in distinguishing breast tumors in ultrasound images.
abstract: OBJECTIVE
  This work aims to investigate the combination of morphological and texture parameters in distinguishing between malignant and benign breast tumors in ultrasound images.
  
  
  METHODS
  Linear discriminant analysis was applied to sets of up to five parameters, and then the performances were assessed using the area A(z) (± standard error) under the receiver operator characteristic curve, accuracy (Ac), sensitivity (Se), specificity (Sp), positive predictive value, and negative predictive value.
  
  
  RESULTS
  The most relevant individual parameter was the normalized residual value (nrv), calculated from the convex polygon technique. The best performance among all studied combinations was achieved by two morphological and three texture parameters (nrv, con, std, R, and asm(i)), which correctly distinguished nearly 85% of the breast tumors.
  
  
  CONCLUSIONS
  This result indicates that the combination of morphological and texture parameters may be useful to assist physicians in the diagnostic process, especially if it is associated with an automatic classification tool.
authors.affiliation: National Institute of Metrology, Quality and Technology, Duque de Caxias, Brazil. avalvarenga@inmetro.gov.br
authors.forename: Andre Victor
authors.initials: AV
authors.lastname: Alvarenga
authors.forename: Antonio Fernando C
authors.initials: AF
authors.lastname: Infantosi
authors.forename: Wagner C A
authors.initials: WC
authors.lastname: Pereira
authors.forename: Carolina M
authors.initials: CM
authors.lastname: Azevedo
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000379:methods*