title: Ghrelin promotion of oocyte maturation via ERK1/2 pathway in ovis aries.
abstract: Ghrelin has recently garnered increasing attention in biomolecular studies. Ghrelin's growth hormone secretagogue receptor type 1a (GHS--R) is a pleiotropic modulator of diverse biological functions, including energy homeostasis and reproduction. This study sought to understand the ways in which ghrelin impacts ERK1/2 and p90rsk during the ovis aries oocyte maturation process. We applied different concentrations of ghrelin and of ghrelin receptor inhibitor (D--Lys3--GHRP--6) to ovis aries oocytes and observed the effects on the ERK1/2 and p90rsk pathway. The ERK1/2 and p90rsk pathway plays an essential role in the in vitro maturation of ovis aries oocytes. This study discovered that ERK1/2 and p90 rsk pathway, during the ovis aries oocyte maturation, was associated with maturation of ovis aries oocyte in vitro.
authors.affiliation: Department of Clinical Laboratory, Inner Mongolia People's Hospital, Hohhot, China.
authors.forename: R
authors.initials: R
authors.lastname: Bai
authors.forename: P
authors.initials: P
authors.lastname: Zhao
authors.forename: G
authors.initials: G
authors.lastname: Cao
authors.forename: S
authors.initials: S
authors.lastname: Wen
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: Q
authors.initials: Q
authors.lastname: Meng
mesh_terms: D000818:Animals; D054439:Ghrelin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism*; D009842:Oligopeptides / Q000494:pharmacology*; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism; D054440:Receptors, Ghrelin / Q000037:antagonists & inhibitors / Q000378:metabolism; D038744:Ribosomal Protein S6 Kinases, 90-kDa / Q000378:metabolism; D034561:Sheep, Domestic / Q000254:growth & development / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: C520836:GHRP-6, Lys(3)-; D054439:Ghrelin; D009842:Oligopeptides; D054440:Receptors, Ghrelin; D038744:Ribosomal Protein S6 Kinases, 90-kDa; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3