title: Antibacterial activity of alkaloids produced by endophytic fungus Aspergillus sp. EJC08 isolated from medical plant Bauhinia guianensis.
abstract: Bauhinia guianensis is a typical plant in the Amazon region belonging to the family Leguminosea, used by local populations for the treatment of infectious and renal diseases. Previous work on the plant B. guianensis led to the isolation of substances with anti-inflammatory and analgesic activities. Thus, compounds isolated from B. guianensis with antimicrobial activities had not been identified. Given that there is a possibility of biological activity reported for a given plant being found in the endophytic fungi, we decided to isolate endophytic fungi from B. guianensis and test their antimicrobial activities. The alkaloids known as fumigaclavine C and pseurotin A were isolated by column chromatography and identified by 1D and 2D NMR techniques and mass spectrometry. The alkaloids are first reported as broad-spectrum antibacterial agents with good activity.
authors.affiliation: a College of Chemistry , Federal University of Pará , Belém , Brazil.
authors.forename: Eduardo Antonio A
authors.initials: EA
authors.lastname: Pinheiro
authors.forename: Josiwander Miranda
authors.initials: JM
authors.lastname: Carvalho
authors.forename: Diellem Cristina P
authors.initials: DC
authors.lastname: dos Santos
authors.forename: André de Oliveira
authors.initials: Ade O
authors.lastname: Feitosa
authors.forename: Patrícia Santana B
authors.initials: PS
authors.lastname: Marinho
authors.forename: Giselle Maria Skelding Pinheiro
authors.initials: GM
authors.lastname: Guilhon
authors.forename: Afonso Duarte L
authors.initials: AD
authors.lastname: de Souza
authors.forename: Felipe Moura A
authors.initials: FM
authors.lastname: da Silva
authors.forename: Andrey Moacir do R
authors.initials: AM
authors.lastname: Marinho
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001230:Aspergillus / Q000378:metabolism*; D036481:Bauhinia / Q000382:microbiology*; D004876:Ergot Alkaloids / Q000737:chemistry / Q000494:pharmacology; D026121:Indole Alkaloids / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D004876:Ergot Alkaloids; D026121:Indole Alkaloids; D011760:Pyrrolidinones; C492995:fumigaclavine C; C012013:pseurotin