title: Neurogliaform cells dynamically regulate somatosensory integration via synapse-specific modulation.
abstract: Despite the prevailing idea that neurogliaform cells produce a spatially unrestricted widespread inhibition, we demonstrate here that their activity attenuates thalamic-evoked feed-forward inhibition in layer IV barrel cortex but has no effect on feed-forward excitation. The result of this circuit selectivity is a dynamic regulation in the temporal window for integration of excitatory thalamic input, thus revealing a new role for neurogliaform cells in shaping sensory processing.
authors.affiliation: Program in Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chittajallu
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Pelkey
authors.forename: Chris J
authors.initials: CJ
authors.lastname: McBain
mesh_terms: D000200:Action Potentials / Q000235:genetics; D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000235:genetics; D018682:GABA Agents / Q000494:pharmacology; D049452:Green Fluorescent Proteins / Q000235:genetics; D006801:Humans; D066298:In Vitro Techniques; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D008959:Models, Neurological; D009433:Neural Inhibition / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D009457:Neuroglia / Q000502:physiology*; D009478:Neuropeptide Y / Q000235:genetics; D009557:Nipecotic Acids / Q000494:pharmacology; D017711:Nonlinear Dynamics; D010320:Parvalbumins / Q000378:metabolism; D010721:Phosphinic Acids / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000235:genetics; D013003:Somatosensory Cortex / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*; D050599:Vesicular Glutamate Transport Protein 2 / Q000378:metabolism
chemical_list: D018682:GABA Agents; D009478:Neuropeptide Y; D009557:Nipecotic Acids; D010320:Parvalbumins; D010721:Phosphinic Acids; D011412:Propanolamines; D011985:Receptors, Serotonin; D050599:Vesicular Glutamate Transport Protein 2; C078730:serotonin 5 receptor; D049452:Green Fluorescent Proteins; C085075:CGP 55845A; C045598:N-(4,4-diphenyl-3-butenyl)nipecotic acid