title: [Effect of dendrobium mixture on hypoglycemic and the apoptosis of islet in rats with type 2 diabetic mellitus].
abstract: OBJECTIVE
  To study the effect of Dendrobium mixture on hypoglycemic and the apoptosis of islet in rats with type 2 diabetic mellitus.
  
  
  METHODS
  Type 2 diabetes mellitus models were induced by high sugar and fat diet and low dose intraperitoneal injection of streptozotocin (STZ) in rats, and treated with Dendrobium mixture (5, 10, 20 g/kg) by intragastric administration. Observed islet cell morphology with histopathological techniques and tested the apoptosis of islet cells by MTT and Annexin V/PI method.
  
  
  CONCLUSIONS
  Dendrobium mixture could reduce the levels of blood glucose, triglyceride and glucosylated serum protein effectively and significantly improve the modeling structure and function of rat pancreatic tissue. The apoptotic islet cells was significantly reduced (P < 0.01) in treatment group compared with the model group.
  
  
  RESULTS
  Dendrobium mixture have a hypoglycemic effect on rat models of type 2 diabetes. It can protect and restore the structure and function of pancreatic tissue.
authors.affiliation: Guangzhou University of Chinese Medicine, School of Chinese Materia Medica, Guangzhou 510006, China. ltmwgx@yahoo.com.cn
authors.forename: Tong-ming
authors.initials: TM
authors.lastname: Li
authors.forename: Min-zhen
authors.initials: MZ
authors.lastname: Deng
mesh_terms: D000284:Administration, Oral; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001786:Blood Glucose / Q000378:metabolism; D002478:Cells, Cultured; D031667:Dendrobium / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D007328:Insulin; D014280:Triglycerides; D013311:Streptozocin; D052216:Glucagon-Like Peptide 1