title: IAP proteins: regulators of cell migration and development.
abstract: The cytoprotective properties of vertebrate inhibitor of apoptosis (IAP) proteins have been the subject of much study. These proteins have, however, emerged as key signaling intermediates modulating a variety of cellular functions through their ability to act as E3 ubiquitin ligases. This review will focus on the cell death-independent roles of the IAP proteins, focusing on recent reports indicating that c-IAPs and XIAP are key molecules involved in modulating cell migration and development.
authors.affiliation: Department of Pathology, The University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Niall S
authors.initials: NS
authors.lastname: Kenneth
authors.forename: Colin S
authors.initials: CS
authors.lastname: Duckett
mesh_terms: D000818:Animals; D017209:Apoptosis; D002465:Cell Movement; D048788:Growth and Development; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D060449:Wnt Signaling Pathway
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D044767:Ubiquitin-Protein Ligases