title: Blueberry extracts protect testis from hypobaric hypoxia induced oxidative stress in rats.
abstract: Exposure to hypobaric hypoxia causes oxidative damage to male rat reproductive function. The aim of this study was to evaluate the protective effect of a blueberry extract (BB-4) in testis of rats exposed to hypobaric hypoxia. Morphometric analysis, cellular DNA fragmentation, glutathione reductase (GR), and superoxide dismutase (SOD) activities were evaluated. Our results showed that supplementation of BB-4 reduced lipid peroxidation, decreased apoptosis, and increased GR and SOD activities in rat testis under hypobaric hypoxia conditions (P < 0.05). Therefore, this study demonstrates that blueberry extract significantly reduced the harmful effects of oxidative stress caused by hypobaric hypoxia in rat testis by affecting glutathione reductase and superoxide dismutase activities.
authors.affiliation: Departamento de Ingeniería Química, Facultad de Ingeniería, Ciencias y Administración, Universidad de La Frontera, Temuco, Chile.
authors.forename: Andrea
authors.initials: A
authors.lastname: Zepeda
authors.forename: Luis G
authors.initials: LG
authors.lastname: Aguayo
authors.forename: Jorge
authors.initials: J
authors.lastname: Fuentealba
authors.forename: Carolina
authors.initials: C
authors.lastname: Figueroa
authors.forename: Alejandro
authors.initials: A
authors.lastname: Acevedo
authors.forename: Perla
authors.initials: P
authors.lastname: Salgado
authors.forename: Gloria M
authors.initials: GM
authors.lastname: Calaf
authors.forename: Jorge
authors.initials: J
authors.lastname: Farías
mesh_terms: D000818:Animals; D029798:Blueberry Plants / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006400:Hematocrit; D000860:Hypoxia / Q000201:enzymology / Q000473:pathology* / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D017392:Thiobarbituric Acid Reactive Substances; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase