title: Cerebral atrophy in elderly with subjective memory complaints.
abstract: OBJECTIVE
  To evaluate ventricular shape differences along the complete surface of the lateral and third ventricles of persons with subjective memory complaints (MC).
  
  
  METHODS
  We included 28 controls and 21 persons with MC. FLAIR, T2, and PD-weighted brain MRI scans were acquired at 1.5 Tesla, followed by semi-automated segmentation of the lateral and third ventricles, and local shape difference analysis based on growing and adaptive meshes. Ventricular meshes were used to highlight local areas with significant differences between controls and persons with MC, determined by permutation tests with a predefined threshold (P = 0.01).
  
  
  RESULTS
  Compared with control subjects, relevant differences were found in the shape of the ventricular surface adjacent to the thalamus and corona radiata in persons with MC. Before correction for multiple comparisons, relevant differences were also found in the shape of the ventricular surface adjacent to the corpus callosum, hippocampus, and amydala.
  
  
  CONCLUSIONS
  Our findings suggest the presence of localized structural brain differences in patients with subjective memory complaints in the thalamus and the corona radiata.
authors.affiliation: Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands. w.m.palm@lumc.nl
authors.forename: Walter M
authors.initials: WM
authors.lastname: Palm
authors.forename: Luca
authors.initials: L
authors.lastname: Ferrarini
authors.forename: Wiesje M
authors.initials: WM
authors.lastname: van der Flier
authors.forename: Rudi G J
authors.initials: RG
authors.lastname: Westendorp
authors.forename: Eduard L E M
authors.initials: EL
authors.lastname: Bollen
authors.forename: Huub A M
authors.initials: HA
authors.lastname: Middelkoop
authors.forename: Julien R
authors.initials: JR
authors.lastname: Milles
authors.forename: Jeroen
authors.initials: J
authors.lastname: van der Grond
authors.forename: Mark A
authors.initials: MA
authors.lastname: van Buchem
mesh_terms: D000368:Aged; D000465:Algorithms; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008569:Memory Disorders / Q000473:pathology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity