title: Understanding ALS: new therapeutic approaches.
abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with motor neuron degeneration, muscle atrophy and paralysis. Although numerous pathological mechanisms have been elucidated, ALS remains an invariably fatal disease in the absence of any effective therapy. The heterogeneity of the disease and the failure to develop satisfactory therapeutic protocols reinforce the view that ALS is a multi-factorial and multi-systemic disease. Thus, a better understanding of the pathogenic mechanisms and study of the potential pathological relationship between the various cellular processes is required to ensure efficacious therapy. The pathogenic mechanisms associated with ALS are reviewed, and the strengths and limitations of some new therapeutic approaches are discussed.
authors.affiliation: Institute Pasteur Cenci Bolognetti, Istituto Italiano di Tecnologia, Department of Anatomy, Histology, Forensic Medicine and Orthopedics - Unit of Histology and Medical Embryology, Istituto Interuniversitario di Miologia, Sapienza University of Rome, Italy. antonio.musaro@uniroma1.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Musarò
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005081:Exercise Therapy; D015316:Genetic Therapy; D006801:Humans
chemical_list: D000911:Antibodies, Monoclonal