title: A randomized trial of aerobic versus resistance exercise in prostate cancer survivors.
abstract: Androgen-deprivation therapy (ADT) for prostate cancer (PCa) has side effects that significantly impair health-related quality of life (HRQOL). Exercise ameliorates many side effects of ADT, but different modalities, particularly in the home-based setting, have not been well studied. In this study the authors randomly assigned 66 PCa survivors receiving ADT to 6 mo of home-based aerobic or resistance training. Psychosocial well-being and physical fitness were measured at baseline, 3 and 6 mo, and then 6 mo postintervention. Intention-to-treat analyses showed that fatigue and HRQOL were not significantly different between groups; however, in a per-protocol analysis the resistance-exercise training group demonstrated clinically significant improvements in HRQOL. Differential within-group effects on physical fitness were also observed at various time points. At all time points, the aerobic-training group engaged in significantly more physical activity than the resistance-training group, a finding that should be further examined given evidence-based guidelines for activity volume in cancer survivors.
authors.affiliation: Kinesiology Program, University of Guelph-Humber, Toronto, ON, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Santa Mina
authors.forename: M H
authors.initials: MH
authors.lastname: Alibhai S
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Matthew
authors.forename: Crissa L
authors.initials: CL
authors.lastname: Guglietti
authors.forename: Meysam
authors.initials: M
authors.lastname: Pirbaglou
authors.forename: John
authors.initials: J
authors.lastname: Trachtenberg
authors.forename: Paul
authors.initials: P
authors.lastname: Ritvo
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000009:adverse effects*; D005081:Exercise Therapy / Q000379:methods*; D005221:Fatigue / Q000503:physiopathology; D006699:Home Care Services; D006801:Humans; D008297:Male; D010349:Patient Compliance; D010809:Physical Fitness / Q000502:physiology*; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000503:physiopathology / Q000534:rehabilitation*; D011788:Quality of Life; D055070:Resistance Training; D017741:Survivors; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists