title: The short- and long-term risk of venous thromboembolism in patients with acute spinal cord injury: a prospective cohort study.
abstract: Venous thromboembolism (VTE) is a frequent complication in the acute setting after spinal cord injury (SCI). Less is known about the long-term risk of VTE in these patients. It was the aim of this study to prospectively evaluate the short- and long-term risk of VTE in a cohort of patients after acute SCI and during rehabilitation and post-rehabilitation follow-up period. From January 2003 to November 2007 all consecutive adult patients admitted to a Spinal Rehabilitation Unit (RU) after surgical treatment in three Neurosurgical Units for SCI, were enrolled. After an accurate evaluation of their neurosurgical medical records the patients were prospectively evaluated for VTE occurrence. Ninety-four patients (80 males; mean age 40.3 years, SD 15.9) were recruited. All the patients received thromboprophylaxis with low-molecular-weight heparin combined with compressive stockings during hospitalization (median duration 7 months, IQR 4.5-8.8). Over a median follow-up period of 36.3 months (IQR 4.4-48) after SCI, VTE was diagnosed in 22 patients (23.4%) The majority of VTE events were recorded during the first three months of follow-up (34.4 VTE events/100 patient-years in the first 3 months and 0.3 VTE events/100 patient-years thereafter); age over 45 years (HR 8.4, 95% CI 3-23.5), previous VTE (HR 6.0, 95% CI 1.6-23.3) and paraplegia (HR 4.7, 95% CI 1.6-13.7) were independently associated with the occurrence of VTE. In conclusion, the risk of VTE in patients suffering from SCI is high despite the use of thromboprophylaxis, in particular in some patients categories. However, this risk appears to be limited to the first 3 months after the index event.
authors.affiliation: Emergency Department, Hospital of Piacenza, Via Taverna 49, Piacenza 29121, Italy. M.giorgi@ausl.pc.it
authors.forename: M
authors.initials: M
authors.lastname: Giorgi Pierfranceschi
authors.forename: Marco P
authors.initials: MP
authors.lastname: Donadini
authors.forename: Francesco
authors.initials: F
authors.lastname: Dentali
authors.forename: Walter
authors.initials: W
authors.lastname: Ageno
authors.forename: Marina
authors.initials: M
authors.lastname: Marazzi
authors.forename: Romeo
authors.initials: R
authors.lastname: Bocchi
authors.forename: Davide
authors.initials: D
authors.lastname: Imberti
mesh_terms: D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000925:Anticoagulants / Q000008:administration & dosage; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010264:Paraplegia / Q000453:epidemiology; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011782:Quadriplegia / Q000453:epidemiology; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors; D013119:Spinal Cord Injuries / Q000175:diagnosis / Q000453:epidemiology* / Q000534:rehabilitation; D053828:Stockings, Compression; D013997:Time Factors; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight