title: Prilling for the development of multi-particulate colon drug delivery systems: pectin vs. pectin-alginate beads.
abstract: This paper proposes a multi-particulate drug delivery system produced by prilling technique in combination with an enteric coating. Optimization of process parameters, such as feed viscosity at nozzle, selection of cross-linker, pH of the gelling solution and cross-linking time, allows to obtain beads with strong gelled matrix. Results showed that dextran/piroxicam beads demonstrated high encapsulation efficiency, very narrow dimensional distribution and high sphericity. Coated beads retained shape and narrow size distribution of the uncoated particles. Moreover, the strength of the produced Zn(2+)-pectinate beads allows to reduce Eudragit coating thickness. Piroxicam loaded multi-particulate systems show an interesting prolonged drug release in intestinal fluids. Hence, such platforms could be proposed for the treatment of inflammatory bowel diseases.
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, University of Salerno, I-84084 Fisciano (SA), Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Auriemma
authors.forename: Teresa
authors.initials: T
authors.lastname: Mencherini
authors.forename: Paola
authors.initials: P
authors.lastname: Russo
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Stigliani
authors.forename: Rita P
authors.initials: RP
authors.lastname: Aquino
authors.forename: Pasquale
authors.initials: P
authors.lastname: Del Gaudio
mesh_terms: D000464:Alginates / Q000008:administration & dosage / Q000737:chemistry*; D003106:Colon / Q000293:injuries / Q000473:pathology; D003432:Cross-Linking Reagents; D003911:Dextrans / Q000008:administration & dosage; D016503:Drug Delivery Systems; D005782:Gels / Q000737:chemistry*; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000737:chemistry; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010368:Pectins / Q000008:administration & dosage / Q000737:chemistry; D010894:Piroxicam / Q000008:administration & dosage; D011109:Polymethacrylic Acids / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility; D014783:Viscosity
chemical_list: D000464:Alginates; D003432:Cross-Linking Reagents; D003911:Dextrans; D005782:Gels; D006603:Hexuronic Acids; D011109:Polymethacrylic Acids; D010894:Piroxicam; C038300:methylmethacrylate-methacrylic acid copolymer; D010368:Pectins; D020723:Glucuronic Acid