title: Isolated metachronous splenic metastasis from renal cell carcinoma after 5 years.
abstract: Primary and metastatic tumours of the spleen are uncommon. The incidence of isolated metastasis from other organs is less than 1%. We report the case of a 55-year-old woman with clear cell carcinoma of the kidney, who underwent radical nephrectomy. After a 5-year follow-up period, a hypervascular nodule was detected in the spleen on MRI. Six months later, control MRI showed that its appearance had changed to a hypervascular mass with areas of central necrosis. A splenectomy was performed and histopathological examination of the spleen confirmed the presence of clear cell carcinoma with infiltration of the capsule. This is only the seventh case described in the literature of isolated splenic metastasis from clear cell carcinoma and the first such case containing MRI.
authors.affiliation: Department of Clinical Radiology, Universidade Federal de São Paulo, São Paulo, Brazil. thiagofnunes@hotmail.com
authors.forename: Thiago Franchi
authors.initials: TF
authors.lastname: Nunes
authors.forename: Denis
authors.initials: D
authors.lastname: Szejnfeld
authors.forename: Luciana Nakao Odashiro
authors.initials: LN
authors.lastname: Miiji
authors.forename: Suzan Menasce
authors.initials: SM
authors.lastname: Goldman
mesh_terms: D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery