title: Mesenchymal stem cells/multipotent mesenchymal stromal cells (MSCs): potential role in healing cutaneous chronic wounds.
abstract: Chronic wounds remain a major challenge in modern medicine and represent a significant health care burden. Several treatments have been suggested, but without a full understanding of the exact mechanism by which chronic wound occurs. Numerous studies have shown that mesenchymal stem cells/multipotent mesenchymal stromal cells (MSCs) may have therapeutic potential in healing cutaneous chronic wounds through various mechanisms. So far, a series of hypotheses have been proposed, but a holistic image of them is lacking. This review provides a systematic analysis of recent research in animal models and preclinical or clinic trails to evaluate the potential role of MSCs in chronic cutaneous wound healing. Most important, we highlight how mesenchymal stem cells could potentially revolutionize our approach to treating cutaneous chronic wounds. Special attention should be focused on ongoing research regarding the challenges in using and prospects of MSCs in clinical settings.
authors.affiliation: Guangzhou General Hospital of Guangzhou Command, GuangDong, The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area, PLA, P R China.
authors.forename: Ji-Ping
authors.initials: JP
authors.lastname: Zou
authors.forename: Sha
authors.initials: S
authors.lastname: Huang
authors.forename: Yan
authors.initials: Y
authors.lastname: Peng
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Liu
authors.forename: Biao
authors.initials: B
authors.lastname: Cheng
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Fu
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Xiang
mesh_terms: D000818:Animals; D001458:Bandages; D002908:Chronic Disease; D004195:Disease Models, Animal; D005260:Female; D006085:Graft Survival; D006801:Humans; D015601:Injury Severity Score; D007871:Leg Ulcer / Q000175:diagnosis / Q000601:surgery*; D035002:Lower Extremity / Q000503:physiopathology / Q000601:surgery; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D059630:Mesenchymal Stem Cells; D011379:Prognosis; D018570:Risk Assessment; D012867:Skin / Q000293:injuries; D012871:Skin Diseases / Q000175:diagnosis / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*