title: Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma.
abstract: The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-1, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors. Our study demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy and the expression of GLUT-1, PI3K and p-Akt were factors predictive of recurrence by univariate analyses. In multivariate analyses, perineural invasion, a positive resection margin and p-Akt were significant predictors of recurrence. Initial surgery is very significant in the recurrence of ACC. Overexpression of GLUT-1, PI3K and p-Akt may also play a role in its development and recurrence.
authors.affiliation: Department of Otolaryngology, The Second Hospital of Jiaxing City, Jiaxing 314000; ; Departments of Otolaryngology.
authors.forename: Jin
authors.initials: J
authors.lastname: Fang
authors.forename: Yang-Yang
authors.initials: YY
authors.lastname: Bao
authors.forename: Shui-Hong
authors.initials: SH
authors.lastname: Zhou
authors.forename: Xing-Mei
authors.initials: XM
authors.lastname: Luo
authors.forename: Hong-Tian
authors.initials: HT
authors.lastname: Yao
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: He
authors.forename: Qin-Ying
authors.initials: QY
authors.lastname: Wang