title: Bio-based biodegradable and biocompatible hyperbranched polyurethane: a scaffold for tissue engineering.
abstract: Hyperbranched polyurethanes are synthesized using TDI, PCL diol, butanediol, and pentaerythritol (1-5 wt%) as the B(4)  reactant with and without the monoglyceride of sunflower oil. The biodegradation, physico-mechanical, and thermal properties are found to be tailored by varying the percentage weight of the branching unit. An MTT/hemolytic assay and subcutaneous implantation in Wistar rats followed by cytokine/ALP assay and histopathology studies confirm a better biocompatibility of HBPU with MG than without MG. HBPU supports the proliferation of dermatocytes with no toxic effect in major organs, in addition the in vitro degraded products are non-toxic. Cell adherence and proliferation endorse the bio-based HBPU as a prospective scaffold material in the niche of tissue engineering.
authors.affiliation: Advanced Polymer & Nanomaterial Laboratory, Department of Chemical Sciences, Tezpur University, Tezpur 784028, India.
authors.forename: Beauty
authors.initials: B
authors.lastname: Das
authors.forename: Pronobesh
authors.initials: P
authors.lastname: Chattopadhyay
authors.forename: Manabendra
authors.initials: M
authors.lastname: Mandal
authors.forename: Brigitte
authors.initials: B
authors.lastname: Voit
authors.forename: Niranjan
authors.initials: N
authors.lastname: Karak
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D002448:Cell Adhesion; D049109:Cell Proliferation; D008297:Male; D008422:Materials Testing; D011140:Polyurethanes / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D011140:Polyurethanes