title: Necrobiotic xanthogranuloma as an unusual cause of refractive chronic bilateral leg ulceration.
abstract: Necrobiotic xanthogranuloma is a progressive histiocytic granulomatous disease with frequent extracutaneous involvement. We have documented an unusual case of necrobiotic xanthogranuloma in a 58-year-old man with a history of recalcitrant and chronic arm and leg ulcerations in the absence of characteristic periorbital involvement. Our patient demonstrates a therapeutic challenge and may display a new necrobiotic inflammatory disorder not previously characterized.
authors.affiliation: University of Toronto, Toronto, Ontario, Canada. nazli.ghiasi@utoronto.ca
authors.forename: Nazli
authors.initials: N
authors.lastname: Ghiasi
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Alavi
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Coutts
authors.forename: Danny
authors.initials: D
authors.lastname: Ghazarian
authors.forename: R Gary
authors.initials: RG
authors.lastname: Sibbald
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001707:Biopsy, Needle; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007871:Leg Ulcer / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D058252:Necrobiotic Xanthogranuloma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D000305:Adrenal Cortex Hormones