title: Impact of recipient age on whole organ pancreas transplantation.
abstract: OBJECTIVE
  The goal of this study was to assess the impact of recipient age on post-transplant outcome.
  
  
  METHODS
  All pancreas transplants performed at Indiana University between 2003 and 2011 were reviewed. Demographic data were compared using standard chi-square and ANOVA testing. Standard Cox regression survival analysis was performed using a direct entry method for covariates.
  
  
  RESULTS
  Patients (n = 405) were divided by decade: <30 yr (n = 37), 30-39 (n = 109), 40-49 (n = 156), 50-59 (n = 85), and ≥ 60 yr of age (n = 18). Group demographics did not differ except for median ischemia time, which was between 7.0 and 8.5 h (p = 0.02). Early graft loss and one yr graft and patient survival were similar between the groups. Long-term patient survival demonstrated a trend toward decreased five-yr survival with increasing recipient age (p = NS). Graft survival at five yr by Cox regression was the lowest for the <30 yr group (74%), while all other groups were similar around 80% (p = NS).
  
  
  CONCLUSIONS
  No statistically significant differences in pancreas transplant outcomes were demonstrated when recipients were stratified by recipient age. These results suggest that older recipients can successfully undergo pancreas transplantation and expect five-yr outcomes similar to those seen in younger recipients.
authors.affiliation: Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Ashesh P
authors.initials: AP
authors.lastname: Shah
authors.forename: Richard S
authors.initials: RS
authors.lastname: Mangus
authors.forename: John A
authors.initials: JA
authors.lastname: Powelson
authors.forename: Kannan P
authors.initials: KP
authors.lastname: Samy
authors.forename: Tim E
authors.initials: TE
authors.lastname: Taber
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Goble
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Fridell
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D009927:Tissue and Organ Procurement; D055815:Young Adult