title: Preexposure prophylaxis for adolescents and young adults at risk for HIV infection: is an ounce of prevention worth a pound of cure?
abstract: An alarming proportion of incident human immunodeficiency virus (HIV) infections worldwide occur in youth. In the United States, 69% of all new infections among youth occurred in young men who have sex with men (YMSM). Recent studies show the promise of preexposure prophylaxis (PrEP) for preventing HIV infection, but research efforts suffer from disproportionately low representation of the youth who are most at risk. Youth-focused research is critical and should include behavioral, community, and biomedical interventions to create a comprehensive HIV prevention package. The many ethical, legal, and regulatory considerations in conducting HIV research among, and in providing care services to, youth must be addressed so that those at high risk and most likely to benefit can have unfettered access to safe and effective health-promoting interventions. YMSM and minority youth are at substantial HIV risk and urgently need effective HIV prevention tools for which the short and long-term benefits and risks have been carefully considered.
authors.affiliation: Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-7510, USA.
authors.forename: Jill E
authors.initials: JE
authors.lastname: Pace
authors.forename: George K
authors.initials: GK
authors.lastname: Siberry
authors.forename: Rohan
authors.initials: R
authors.lastname: Hazra
authors.forename: Bill G
authors.initials: BG
authors.lastname: Kapogiannis
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D019380:Anti-HIV Agents / Q000191:economics / Q000627:therapeutic use; D003140:Communicable Disease Control / Q000191:economics / Q000331:legislation & jurisprudence; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D011322:Primary Prevention / Q000191:economics* / Q000941:ethics / Q000331:legislation & jurisprudence; D012306:Risk; D014481:United States; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents