title: Neural stem cells-trends and advances.
abstract: For many years, accepted dogma held that brain is a static organ with no possibility of regeneration of cells in injured or diseased human brain. However, recent preclinical reports have shown regenerative potential of neural stem cells using various injury models. This has resulted in renewed hope for those suffering from spinal cord injury and neural damage. As the potential of stem cell therapy gained impact, these claims, in particular, led to widespread enthusiasm that acute and chronic injury of the nervous system would soon be a problem of the past. The devastation caused by injury or diseases of the brain and spinal cord led to wide premature acceptance that "neural stem cells (NSCs)" derived from embryonic, fetal or adult sources would soon be effective in reversing neural and spinal trauma. However, neural therapy with stem cells has not been realized to its fullest extent. Although, discrete population of regenerative stem cells seems to be present in specific areas of human brain, the function of these cells is unclear. However, similar cells in animals seem to play important role in postnatal growth as well as recovery of neural tissue from injury, anoxia, or disease.
authors.affiliation: Foundation for Florida Development and Research, Palmetto, Florida.
authors.forename: Denis
authors.initials: D
authors.lastname: English
authors.forename: Neel K
authors.initials: NK
authors.lastname: Sharma
authors.forename: Kaushal
authors.initials: K
authors.lastname: Sharma
authors.forename: Akshay
authors.initials: A
authors.lastname: Anand
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D002454:Cell Differentiation; D054338:Cell Transdifferentiation; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism*; D055495:Neurogenesis; D012038:Regeneration; D012160:Retina / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D055351:Retinal Neurons / Q000166:cytology / Q000378:metabolism; D017948:Retinal Rod Photoreceptor Cells / Q000378:metabolism* / Q000637:transplantation; D033581:Stem Cell Transplantation; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A