title: Pain catastrophizing is associated with dental pain in a stressful context.
abstract: Pain is associated with anxiety in a dental setting. It has remained unclear how cognitive-affective factors modulate pain and anxiety in a stressful context, such as receiving dental procedures. We hypothesized that both the situational factor (unpredictability about painful stimuli) and the trait factor (pain catastrophizing, i.e., the tendency to interpret pain in negative orientation) account for dental pain. Fifteen healthy participants were recruited to perform an associative learning task. They were asked to learn the pairing between visual cues and the intensity of incoming painful stimuli delivered at the right upper central incisor. Brain activation associated with pain was recorded by functional magnetic resonance imaging (fMRI). The participants reported increased anxiety and pain in the stressful context, where stimuli intensity was not predicted by the preceding cue. The score of the Pain Catastrophizing Scale was positively correlated with the increased pain modulated by unpredictability. Brain activation at the right posterior hippocampus, a region critically related to associative learning of aversive stimuli and context, was correlated with the individual catastrophizing level. Our findings suggest that both the situational factor (unpredictability) and the trait factor (catastrophizing) influence dental pain, highlighting the role of cognitive-affective factors in pain control of dental patients.
authors.affiliation: Integrated Brain Research Unit, Department of Medical Research & Education, Taipei Veterans General Hospital, Taipei, Taiwan. winzcsl@gmail.com
authors.forename: C-S
authors.initials: CS
authors.lastname: Lin
authors.forename: D M
authors.initials: DM
authors.lastname: Niddam
authors.forename: M-L
authors.initials: ML
authors.lastname: Hsu
authors.forename: J-C
authors.initials: JC
authors.lastname: Hsieh
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology; D001245:Association Learning; D058443:Catastrophization / Q000503:physiopathology / Q000523:psychology*; D003071:Cognition / Q000502:physiology; D003287:Contrast Media; D003463:Cues; D016854:Dental Anxiety / Q000503:physiopathology / Q000523:psychology*; D003729:Dental Care / Q000523:psychology*; D003782:Dental Pulp / Q000503:physiopathology; D004558:Electric Stimulation; D005260:Female; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007180:Incisor / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010146:Pain / Q000503:physiopathology / Q000523:psychology*; D013315:Stress, Psychological / Q000503:physiopathology / Q000523:psychology*
chemical_list: D003287:Contrast Media