title: A safe and facile route to imidazole-1-sulfonyl azide as a diazotransfer reagent.
abstract: A facile approach to the diazotransfer reagent of imidazole-1-sulfonyl azide was reported. The procedure was well optimized to clarify potential explosion risks. A high production yield as well as small batch variation was achieved even without careful pretreatment of reagents and solvents. HPLC and NMR methods to monitor the process were provided. These features made this protocol suitable for large scale preparation in academia and industry as well.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ye
authors.forename: Ruihua
authors.initials: R
authors.lastname: Liu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Li
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Liu
authors.forename: Haixin
authors.initials: H
authors.lastname: Yuan
authors.forename: Weikang
authors.initials: W
authors.lastname: Guo
authors.forename: Lifei
authors.initials: L
authors.lastname: Zhou
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Cao
authors.forename: Hongqi
authors.initials: H
authors.lastname: Tian
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
authors.forename: Peng George
authors.initials: PG
authors.lastname: Wang
mesh_terms: D001386:Azides / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001386:Azides; D007093:Imidazoles; D007202:Indicators and Reagents; D013450:Sulfones; C580844:imidazole-1-sulfonyl azide