title: Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco.
abstract: BACKGROUND
  Breast cancer may be classified into luminal A, luminal B, HER2+/ER-, basal-like and normal-like subtypes based on gene expression profiling or immunohistochemical (IHC) characteristics. The aim of our study is to show the molecular profile characteristic of breast cancer in the North African population of Morocco. This work showed preliminary results and correlations with clinicopathological and histological parameters. Three hundred and ninety primary breast carcinomas tumor tissues were immunostained for ER, PR, HER2, CK5/6, CK8/18 and Ki67 using paraffin tissue.
  
  
  METHODS
  We reviewed 390 cases of breast cancer diagnosed on January 2008 to December 2011 at the Department of pathology, Hassan II teaching hospital, Fez, Morocco. Age, size tumor, metastatic profile, node involvement profile, histological type and immunohistochemical profile were studied.
  
  
  RESULTS
  The average age was 46 years; our patients were diagnosed late with a high average tumor size. Luminal B subtype was more prevalent (41.8%), followed by luminal A (30.5%), basal-like (13, 6%), Her2-overexpressing (9, 2%), and unclassified subtype (4.9%).
  
  
  CONCLUSIONS
  This study showed that molecular classification and biological profile may be different according to geographical distribution, to encourage further studies to know the genomic profile of tumors and the environment.
authors.affiliation: Department of Pathology, Hassan II teaching hospital, Fez, Morocco. hinde0012@hotmail.com
authors.forename: Hinde
authors.initials: H
authors.lastname: El Fatemi
authors.forename: Sanae
authors.initials: S
authors.lastname: Chahbouni
authors.forename: Sofia
authors.initials: S
authors.lastname: Jayi
authors.forename: Kaoutar
authors.initials: K
authors.lastname: Moumna
authors.forename: My Abdelilah
authors.initials: MA
authors.lastname: Melhouf
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: Bannani
authors.forename: Omar
authors.initials: O
authors.lastname: Mesbahi
authors.forename: Afaf
authors.initials: A
authors.lastname: Amarti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D044383:Black People; D001943:Breast Neoplasms / Q000737:chemistry* / Q000145:classification / Q000208:ethnology / Q000473:pathology; D002277:Carcinoma / Q000737:chemistry* / Q000145:classification / Q000208:ethnology / Q000556:secondary; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009018:Morocco / Q000453:epidemiology; D016612:Paraffin Embedding; D011237:Predictive Value of Tests; D015995:Prevalence; D047368:Tumor Burden; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor