title: YB-1: oncoprotein, prognostic marker and therapeutic target?
abstract: Hanahan and Weinberg have proposed the 'hallmarks of cancer' to cover the biological changes required for the development and persistence of tumours [Hanahan and Weinberg (2011) Cell 144, 646-674]. We have noted that many of these cancer hallmarks are facilitated by the multifunctional protein YB-1 (Y-box-binding protein 1). In the present review we evaluate the literature and show how YB-1 modulates/regulates cellular signalling pathways within each of these hallmarks. For example, we describe how YB-1 regulates multiple proliferation pathways, overrides cell-cycle check points, promotes replicative immortality and genomic instability, may regulate angiogenesis, has a role in invasion and metastasis, and promotes inflammation. We also argue that there is strong and sufficient evidence to suggest that YB-1 is an excellent molecular marker of cancer progression that could be used in the clinic, and that YB-1 could be a useful target for cancer therapy.
authors.affiliation: Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. a.lasham@auckland.ac.nz
authors.forename: Annette
authors.initials: A
authors.lastname: Lasham
authors.forename: Cristin G
authors.initials: CG
authors.lastname: Print
authors.forename: Adele G
authors.initials: AG
authors.lastname: Woolley
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Dunn
authors.forename: Antony W
authors.initials: AW
authors.lastname: Braithwaite
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D014408:Biomarkers, Tumor / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects; D018450:Disease Progression; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000378:metabolism; D015513:Oncogene Proteins / Q000502:physiology; D011379:Prognosis; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D051840:Y-Box-Binding Protein 1 / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D015513:Oncogene Proteins; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human