title: Nutritional intervention in patients with Cystic Fibrosis: a systematic review.
abstract: BACKGROUND
  To systematically assess the literature published after 1997 describing the effectiveness of nutritional interventions in Cystic Fibrosis patients.
  
  
  METHODS
  An online search in PUBMED, EMBASE and COCHRANE databases was conducted. Original studies with 4 patients or more, describing a nutritional intervention and giving at least weight as an outcome parameter were included.
  
  
  RESULTS
  The inclusion criteria were met by 17 articles, focusing on respectively behavioural interventions (n=6), oral supplementation (n=4) or enteral tube feeding (n=7). This latter intervention was universally successful to induce weight gain. One behavioural study and 2 oral supplementation studies also reported significant weight gain.
  
  
  CONCLUSIONS
  Enteral tube feeding is effective to improve nutritional status, while the described effects of behavioural intervention and oral supplementation are not consistent at present.
authors.affiliation: Julius Centre for Health Sciences and Primary Care, Dietetics and, Cystic Fibrosis Centre Utrecht, University Medical Centre Utrecht, Internal address KH.01.419.0, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. Electronic address: j.w.woestenenk@umcutrecht.nl.
authors.forename: J W
authors.initials: JW
authors.lastname: Woestenenk
authors.affiliation: Department of Paediatric Gastroenterology and, Cystic Fibrosis Centre Utrecht, University Medical Centre Utrecht, Internal address KE.04.133.1, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
authors.forename: S J A M
authors.initials: SJ
authors.lastname: Castelijns
authors.affiliation: Department of Paediatric Pulmonology and, Cystic Fibrosis Centre Utrecht, University Medical Centre Utrecht, Internal address KH.01.419.0, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
authors.forename: C K
authors.initials: CK
authors.lastname: van der Ent
authors.affiliation: Department of Paediatric Gastroenterology and, Cystic Fibrosis Centre Utrecht, University Medical Centre Utrecht, Internal address KE.04.133.1, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
authors.forename: R H J
authors.initials: RH
authors.lastname: Houwen
mesh_terms: D003550:Cystic Fibrosis / Q000178:diet therapy*; D004750:Enteral Nutrition; D005774:Gastrostomy; D006801:Humans; D009752:Nutritional Status; D018529:Nutritional Support / Q000379:methods*