title: Carbohydrate-conjugated porphyrin dimers: synthesis and photobiological evaluation for a potential application in one-photon and two-photon photodynamic therapy.
abstract: We report the synthesis of bioconjugated zinc porphyrin dimers 1a-e designed as photosensitizers for one-photon and two-photon excited photodynamic therapy. These macrocycles are substituted with carbohydrate units (glucose, mannose, lactose) in order to target tumor cells over-expressing lectin membrane receptors. Polarity, singlet oxygen production and in vitro photocytotoxicity are studied to determine their photodynamic therapy potentiality.
authors.affiliation: Institut Curie, Section de Recherches, Bât 110-112, Centre Universitaire, F-91405 Orsay, France. guillaume.garcia@curie.fr
authors.forename: Guillaume
authors.initials: G
authors.lastname: Garcia
authors.forename: Fabien
authors.initials: F
authors.lastname: Hammerer
authors.forename: Florent
authors.initials: F
authors.lastname: Poyer
authors.forename: Sylvain
authors.initials: S
authors.lastname: Achelle
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Teulade-Fichou
authors.forename: Philippe
authors.initials: P
authors.lastname: Maillard
mesh_terms: D045744:Cell Line, Tumor; D019281:Dimerization; D005947:Glucose / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006001:Glycoconjugates / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D007785:Lactose / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D008358:Mannose / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D008665:Metalloporphyrins / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000378:metabolism
chemical_list: D006001:Glycoconjugates; D008665:Metalloporphyrins; D017319:Photosensitizing Agents; C017802:zinc hematoporphyrin; D026082:Singlet Oxygen; D005947:Glucose; D007785:Lactose; D008358:Mannose