title: Weight reduction and pioglitazone ameliorate polycystic ovary syndrome after removal of a Sertoli-stromal cell tumor.
abstract: This report presents an unusual case of Sertoli-stromal cell tumor and polycystic ovary syndrome successfully treated with weight reduction and an insulin-sensitizing agent. A 22-year-old woman, gravida 0, para 0, visited our hospital for the first time with a 12-year history of secondary amenorrhea and hypertrichosis. Transvaginal ultrasonography revealed a solid tumor in the right ovary. Right salpingo-oophorectomy was performed and pathological examination confirmed a Sertoli-stromal cell tumor. The patient's serum androgen levels declined postoperatively, but remained above normal. Pioglitazone treatment for 6 months also significantly reduced serum androgen levels, but they still remained above normal. However, after losing 12 kg of body weight, the patient's serum androgen levels declined to normal, and spontaneous menstruation became regular. Weight reduction with pioglitazone is an effective means of treating hyperandrogenism.
authors.affiliation: Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Baba
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Endo
authors.forename: Keiko
authors.initials: K
authors.lastname: Ikeda
authors.forename: Ayumi
authors.initials: A
authors.lastname: Shimizu
authors.forename: Miyuki
authors.initials: M
authors.lastname: Morishita
authors.forename: Yoshika
authors.initials: Y
authors.lastname: Kuno
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Honnma
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Kiya
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Ishioka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Saito