title: erbB expression changes in ethanol and 7,12- dimethylbenz (a)anthracene-induced oral carcinogenesis.
abstract: OBJECTIVE
  [corrected] The aim of this study was to determine erbB expression in normal mucosa, oral dysplasia, and invasive carcinomas developed in the hamster's buccal pouch chemical carcinogenesis model.
  
  
  METHODS
  Fifty Syrian golden hamsters were equally divided in five groups (A-E); two controls and three experimental group exposed to alcohol, DMBA, or both for 14 weeks. Number of tumors per cheek, volume, histological condition, erbB expression were determined and results were analyzed by the Mann-Whitney U and Dunn's test.
  
  
  RESULTS
  Control groups and those exposed to alcohol (A, B and C respectively) only presented clinical and histological normal mucosa; while those exposed to DMBA or DMBA plus alcohol (D and E groups) developed dysplasia and invasive carcinomas. erbB2, erbB3, and erbB4 increased their expression in alcohol-exposed mucosa, dysplasia, and invasive carcinomas. We observed a similar expression level for erbB2 in dysplasia and carcinomas; while, erbB3 and erbB4 were similar only in carcinomas.
  
  
  CONCLUSIONS
  The DMBA and alcohol can be considered as carcinogen and promoter for oral carcinogenesis. The erbB expression is different according to their histological condition, suggesting differential participation of the erbB family in oral carcinogenesis induced by alcohol and DMBA.
authors.affiliation: Immunology Laboratory, Postgraduate and Research Division, Dental School, National Autonomous University of Mexico, Mexico, DF, Mexico.
authors.forename: Luis-Fernando
authors.initials: LF
authors.lastname: Jacinto-Alemán
authors.forename: Alejandro
authors.initials: A
authors.lastname: García-Carrancá
authors.forename: Elba-Rosa
authors.initials: ER
authors.lastname: Leyba-Huerta
authors.forename: Edgar
authors.initials: E
authors.lastname: Zenteno-Galindo
authors.forename: María-Dolores
authors.initials: MD
authors.lastname: Jiménez-Farfán
authors.forename: Juan-Carlos
authors.initials: JC
authors.lastname: Hernández-Guerrero
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000235:genetics*; D006224:Cricetinae; D000431:Ethanol / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D018815:Genes, erbB / Q000235:genetics*; D008297:Male; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000235:genetics*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics*
chemical_list: D002273:Carcinogens; D000431:Ethanol; D015127:9,10-Dimethyl-1,2-benzanthracene