title: Liver-metastatic potential of colorectal cancer is related to the stromal composition of the tumour.
abstract: BACKGROUND
  The tumour stroma is an important modulator of cancer cell behaviour. The aim of this study was to compare the stromal composition between primary colorectal cancer (CRC) and colorectal liver metastases (CLM).
  
  
  METHODS
  The stromal composition in matched tissue sections of CRC and subsequent CLM was analysed, and related to clinical parameters.
  
  
  RESULTS
  Differences in the expression pattern of type I collagen and type IV collagen in CRC was related to a higher risk of CLM. Two types of CLM the desmoplastic and pushing type were identified. The time between CRC and diagnosis of CLM was shorter (p=0.047) for desmoplastic CLM. The mortality rate was higher for pushing CLM due to frequent extrahepatic disseminated disease. A difference in the overall survival rate between patients with desmoplastic and those with pushing CLM was seen at follow-up of more than 60 months (p=0.046).
  
  
  CONCLUSIONS
  The liver-metastasizing potential is related to the stromal composition of primary CRC. There are distinct growth patterns in CLM with differences in stromal composition and clinical outcome.
authors.affiliation: Department of Surgical and Perioperative Sciences, Surgery, Umeå University, 90185 Umeå, Sweden.
authors.forename: Hanna
authors.initials: H
authors.lastname: Nyström
authors.forename: Peter
authors.initials: P
authors.lastname: Naredi
authors.forename: Anette
authors.initials: A
authors.lastname: Berglund
authors.forename: Richard
authors.initials: R
authors.lastname: Palmqvist
authors.forename: Björn
authors.initials: B
authors.lastname: Tavelin
authors.forename: Malin
authors.initials: M
authors.lastname: Sund
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D048708:Cell Growth Processes / Q000502:physiology; D015331:Cohort Studies; D024042:Collagen Type I / Q000096:biosynthesis; D024141:Collagen Type IV / Q000096:biosynthesis; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary* / Q000601:surgery; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D017154:Stromal Cells / Q000473:pathology*; D015996:Survival Rate
chemical_list: D024042:Collagen Type I; D024141:Collagen Type IV