title: Significant increase in anxiety during aging in mGlu5 receptor knockout mice.
abstract: Glutamatergic mechanisms regulate neuronal circuits implicated in mood and anxiety. Emotional disorders as anxiety and depression are particularly difficult to treat during aging and mechanisms underlying emotional disturbances in the brain of the elderly are poorly understood. This may result from the small number of studies investigating these disorders in aged animals. Among glutamate receptors, metabotropic mGlu5 receptors are thought to play an important role, since their pharmacological blockade induces strong anxiolytic effects. However, the implication of mGlu5 in regulating anxiety is not yet completely understood. Here we analyzed both young adult and aged mice lacking mGlu5 receptors, to clarify, if genetic deletion of the receptor induces similar to pharmacological blockade anxiolytic effects. Unexpectedly, mGlu5 receptor knockout (KO) mice showed increased anxiety accentuating with aging. In contrast, young adult mice displayed an anti-depressive-like phenotype that was no longer detectable in aged animals. Our data support important distinct roles of mGlu5 receptors in modulating anxiety and depression during aging.
authors.affiliation: RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg, Germany. Dragos.Inta@zi-mannheim.de
authors.forename: D
authors.initials: D
authors.lastname: Inta
authors.forename: M A
authors.initials: MA
authors.lastname: Vogt
authors.forename: A
authors.initials: A
authors.lastname: Luoni
authors.forename: D
authors.initials: D
authors.lastname: Filipović
authors.forename: J M
authors.initials: JM
authors.lastname: Lima-Ojeda
authors.forename: N
authors.initials: N
authors.lastname: Pfeiffer
authors.forename: F
authors.initials: F
authors.lastname: Gasparini
authors.forename: M A
authors.initials: MA
authors.lastname: Riva
authors.forename: P
authors.initials: P
authors.lastname: Gass
mesh_terms: D000367:Age Factors; D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000523:psychology; D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000378:metabolism* / Q000523:psychology; D001522:Behavior, Animal / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics / Q000378:metabolism*
chemical_list: D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate