title: A hand-held beta imaging probe for FDG.
abstract: OBJECTIVE
  Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe™ (IBP™) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as (18)FDG, (131)I and (32)P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments.
  
  
  METHODS
  We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of (18)FDG-avid primary tumors and metastases in an animal model.
  
  
  RESULTS
  We have demonstrated a device which can generate beta images from (18)FDG avid lesions in an animal model.
  
  
  CONCLUSIONS
  It is feasible to image beta irradiation in animal models of cancer given (18)FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.
authors.affiliation: Radiation Monitoring Devices, Inc., Watertown, MA 02472, USA.
authors.forename: Bipin
authors.initials: B
authors.lastname: Singh
authors.forename: Brendan C
authors.initials: BC
authors.lastname: Stack
authors.forename: Samta
authors.initials: S
authors.lastname: Thacker
authors.forename: Valeriy
authors.initials: V
authors.lastname: Gaysinskiy
authors.forename: Twyla
authors.initials: T
authors.lastname: Bartel
authors.forename: Val
authors.initials: V
authors.lastname: Lowe
authors.forename: Steven
authors.initials: S
authors.lastname: Cool
authors.forename: Gerald
authors.initials: G
authors.lastname: Entine
authors.forename: Vivek
authors.initials: V
authors.lastname: Nagarkar
mesh_terms: D000818:Animals; D001610:Beta Particles; D003952:Diagnostic Imaging / Q000295:instrumentation*; D019788:Fluorodeoxyglucose F18; D009062:Mouth Neoplasms / Q000175:diagnosis; D019047:Phantoms, Imaging; D011817:Rabbits; D013997:Time Factors; D014965:X-Rays
chemical_list: D019788:Fluorodeoxyglucose F18