title: Circulating levels of lipocalin-2 and retinol-binding protein-4 are increased in psoriatic patients and correlated with baseline PASI.
abstract: Psoriasis has been related to metabolic syndrome (MS). Adipocytokines produced by white adipose tissue may be involved in the pathogenesis of psoriasis and its association with MS. Our objectives were to characterize the profile of a number of different inflammatory and atherogenic markers, vitamins, adipokines and cytokines and their potential involvement in MS in patients with moderate-to-severe psoriasis without joint involvement compared to anthropometrically matched controls, and to evaluate correlation with severity of the skin disease and changes after narrow-band UVB (NB-UVB) phototherapy. We designed a prospective cross-sectional study. Baseline waist circumference, body fat composition, lipid, carbohydrate and calcium metabolism profile, inflammation markers, homocysteine and vitamins D, B6, B12 and folic acid, leptin, resistin, omentin, lipocalin-2, adipocyte fatty acid-binding protein, retinol-binding protein-4 (RBP-4), interleukin-6, soluble tumour necrosis factor receptor 1 (sTNFR1) and interleukin-17 of 50 psoriasis patients and 50 gender, age and body mass index-matched controls were recorded, then evaluated after NB-UVB in the patients. The patients had higher baseline serum concentrations of leptin, RBP-4, lipocalin-2 and sTNFR1. Baseline psoriasis area and severity index correlated with serum concentrations of RBP-4 and lipocalin-2 only. Principal components analysis disclosed a component including vitamins B12, B6, folic acid, calcidiol and HDL-cholesterol that was only present in healthy controls and opposed to a cluster of variables which promote MS. This component was absent in the patients. Our results point to lipocalin-2 and RBP-4 as relevant mediators of the trend towards MS in psoriatic patients.
authors.affiliation: Department of Dermatology, Hospital Universitari Parc Taulí, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí, UAB, Universitat Autònoma de Barcelona, Campus d'excelència Internacional, Bellaterra, Spain. xurxoromani@hotmail.com
authors.forename: Jorge
authors.initials: J
authors.lastname: Romaní
authors.forename: Assumpta
authors.initials: A
authors.lastname: Caixàs
authors.forename: Victoria
authors.initials: V
authors.lastname: Ceperuelo-Mallafré
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Carrascosa
authors.forename: Miquel
authors.initials: M
authors.lastname: Ribera
authors.forename: Mercedes
authors.initials: M
authors.lastname: Rigla
authors.forename: Joan
authors.initials: J
authors.lastname: Vendrell
authors.forename: Jesús
authors.initials: J
authors.lastname: Luelmo
mesh_terms: D000209:Acute-Phase Proteins; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007223:Infant; D020738:Leptin / Q000097:blood; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000097:blood*; D011565:Psoriasis / Q000097:blood* / Q000150:complications / Q000473:pathology*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*; D012720:Severity of Illness Index; D014467:Ultraviolet Therapy; D014805:Vitamin B 12 / Q000378:metabolism; D055815:Young Adult
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C489506:LCN2 protein, human; D020738:Leptin; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; C101326:RBP4 protein, human; D047888:Receptors, Tumor Necrosis Factor, Type I; D054839:Retinol-Binding Proteins, Plasma; D014805:Vitamin B 12