title: HLA-G expressing DC-10 and CD4(+) T cells accumulate in human decidua during pregnancy.
abstract: Multiple mechanisms underlie the surprising willingness of mothers to tolerate the semi-allogeneic fetal tissues during pregnancy. Chief among these is the expression of the HLA-G molecules that has been largely demonstrated to be responsible for reprogramming the local maternal immune response towards tolerance. We recently identified a subset of tolerogenic dendritic cells, DC-10 that secrete high amounts of IL-10 and express high levels of HLA-G and its ligand ILT4. DC-10 are present in the peripheral blood and are essential in inducing adaptive regulatory T cells. We investigated the presence of DC-10 and HLA-G-expressing CD4(+) T cells in human decidua in the first trimester of pregnancy. Results showed that these cells are highly represented in human decidua as compared to the peripheral blood. This is the first report describing decidual DC-10 and CD4(+)HLA-G(+) T cells, strongly suggesting that they may accumulate or be induced at the fetal maternal interface to promote tolerance.
authors.affiliation: San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy.
authors.forename: Giada
authors.initials: G
authors.lastname: Amodio
authors.forename: Alessandra
authors.initials: A
authors.lastname: Mugione
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Sanchez
authors.forename: Paola
authors.initials: P
authors.lastname: Viganò
authors.forename: Massimo
authors.initials: M
authors.lastname: Candiani
authors.forename: Edgardo
authors.initials: E
authors.lastname: Somigliana
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Roncarolo
authors.forename: Paola
authors.initials: P
authors.lastname: Panina-Bordignon
authors.forename: Silvia
authors.initials: S
authors.lastname: Gregori
mesh_terms: D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D018949:Antigens, CD1; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology; D003656:Decidua / Q000166:cytology / Q000276:immunology*; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D005260:Female; D005333:Fetus; D015870:Gene Expression / Q000276:immunology*; D006023:Glycoproteins; D059951:HLA-G Antigens / Q000235:genetics / Q000276:immunology*; D054502:Histocompatibility, Maternal-Fetal; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics*; D016130:Immunophenotyping; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology*; D037181:Lectins, C-Type / Q000235:genetics / Q000276:immunology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011956:Receptors, Cell Surface / Q000235:genetics / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015703:Antigens, CD; D018949:Antigens, CD1; D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D059951:HLA-G Antigens; D016753:Interleukin-10; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C437944:CD1C protein, human; C508609:IL10 protein, human