title: Poly(N-vinylpyrrolidone)-modified surfaces for biomedical applications.
abstract: Poly(N-vinylpyrrolidone) (PVP), an important water soluble synthetic polymer, has many desirable properties including low toxicity, chemical stability, and good biocompatibility. Since PVP is hemocompatible and physiologically inactive, it has been used as a blood plasma substitute. Surface modification with PVP has been investigated extensively over the past few years as a means of preventing nonspecific protein adsorption. PVP may therefore be seen as a promising antifouling surface modifier comparable to poly(ethylene glycol) (PEG). In this review, various approaches for the design and preparation of PVP-modified surfaces are summarized and potential biomedical applications of these PVP-modified materials are indicated. Finally, some perspectives on future research on PVP for surface modification are discussed.
authors.affiliation: Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, P R China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liu
authors.forename: Yajun
authors.initials: Y
authors.lastname: Xu
authors.forename: Zhaoqiang
authors.initials: Z
authors.lastname: Wu
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
mesh_terms: D001672:Biocompatible Materials; D005720:Gamma Rays; D010777:Photochemistry / Q000379:methods; D011205:Povidone / Q000737:chemistry* / Q000528:radiation effects; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D011205:Povidone