title: Small bowel capsule endoscopy for management of Crohn's disease: a retrospective tertiary care centre experience.
abstract: BACKGROUND
  The role of small bowel capsule endoscopy in the management of established Crohn's disease is uncertain.
  
  
  METHODS
  A retrospective study of small bowel capsule endoscopy tests performed in a referral centre from 2008 to 2011; 77 tests were performed in patients with known Crohn's disease. Six patients were excluded due to capsule test retention. Patients were classified into 4 indication groups: unexplained anaemia (G1, n = 6); discrepancy between clinical symptoms and morphology (G2, n = 25), full assessment of Crohn's disease location (G3, n = 37) and evaluation of mucosal healing (G4, n = 3).
  
  
  RESULTS
  Twenty-seven (38%) patients had no lesions, 32 (45%) moderate and 12 (17%) severe lesions. Endoscopic lesions were found in 4/6 (67%) G1 patients, 11/25 (44%) G2 and 28/37 (76%) G3 (p < 0.03). Three months after endoscopy was performed, 38/71 patients experienced a change in their treatment that was significantly associated with the severity of endoscopic lesions and with test indications; in 60%, 20% and 58% of patients from G1, G2 and G3, respectively (p < 0.01).
  
  
  CONCLUSIONS
  Small bowel capsule endoscopy resulted in management changes in the majority of patients with established Crohn's disease.
authors.affiliation: Gastroenterology Unit, Hôpital Huriez, Lille University and Hospital, Univ Nord de France, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Dussault
authors.forename: Corinne
authors.initials: C
authors.lastname: Gower-Rousseau
authors.forename: Julia
authors.initials: J
authors.lastname: Salleron
authors.forename: Gwénola
authors.initials: G
authors.lastname: Vernier-Massouille
authors.forename: Julien
authors.initials: J
authors.lastname: Branche
authors.forename: Jean-Frédéric
authors.initials: JF
authors.lastname: Colombel
authors.forename: Vincent
authors.initials: V
authors.lastname: Maunoury
mesh_terms: D000328:Adult; D053704:Capsule Endoscopy / Q000379:methods*; D015331:Cohort Studies; D003424:Crohn Disease / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D055815:Young Adult