title: High-dose pemetrexed in combination with high-dose crizotinib for the treatment of refractory CNS metastases in ALK-rearranged non-small-cell lung cancer.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Leena_Gandhi@dfci.harvard.edu
authors.forename: Leena
authors.initials: L
authors.lastname: Gandhi
authors.forename: Jan
authors.initials: J
authors.lastname: Drappatz
authors.forename: Nikhil H
authors.initials: NH
authors.lastname: Ramaiya
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Otterson
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000556:secondary / Q000628:therapy*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000556:secondary / Q000628:therapy*; D059248:Chemoradiotherapy; D000077547:Crizotinib; D005971:Glutamates / Q000008:administration & dosage; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D008297:Male; D000068437:Pemetrexed; D011720:Pyrazoles / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage; D016634:Radiosurgery; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: D005971:Glutamates; D011720:Pyrazoles; D011725:Pyridines; D000068437:Pemetrexed; D000077547:Crizotinib; D006147:Guanine; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases