title: Aggregation and fibrillogenesis of proteins not associated with disease: a few case studies.
abstract: While amyloid structures have been well characterised in a medical context, there is increasing interest in studying amyloid-like aggregates in other areas, such as food science and nanomaterials. Several proteins relevant to food processing, including serum albumen, lactoglobulin, lysozyme, ovalbumin, casein, and soy protein isolate have been shown to form fibrillar structures under both physiological and non-physiological conditions. These structures are likely to contribute to the structural characteristics of the final food product. In a biotechnological context, proteins such as insulin and eye lens crystallins can be induced to form amyloid structures which can subsequently be used in biotechnology. One example of this is the use of amyloid fibrils as a scaffold for the immobilisation of enzymes. Another current interest in amyloid fibrils is as a storage form for peptide hormones, including insulin, glucagon and calcitonin. Here, we give an overview of a selection of well characterised proteins that have been studied outside the context of disease.
authors.affiliation: Biomolecular Interaction Center and School of Biological Sciences, University of Canterbury, Private Bag 4800, 8020, Christchurch, New Zealand, Moritz.lasse@pg.canterbury.ac.nz.
authors.forename: Moritz
authors.initials: M
authors.lastname: Lassé
authors.forename: Juliet A
authors.initials: JA
authors.lastname: Gerrard
authors.forename: F Grant
authors.initials: FG
authors.lastname: Pearce
mesh_terms: D058227:Amyloidogenic Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D003459:Crystallins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D007782:Lactoglobulins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D009113:Muramidase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D010047:Ovalbumin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D057165:Proteostasis Deficiencies / Q000378:metabolism / Q000473:pathology
chemical_list: D058227:Amyloidogenic Proteins; D003459:Crystallins; D007328:Insulin; D007782:Lactoglobulins; D046912:Multiprotein Complexes; D010047:Ovalbumin; D009113:Muramidase