title: Corynebacterium pyruviciproducens, as an immune modulator, can promote the activity of macrophages and up-regulate antibody response to particulate antigen.
abstract: Corynebacterium pyruviciproducens is a newly discovered Corynebacterium species with no known pathogenic components such as diphtheria toxin and tuberculostearic acid, and it has similar biological properties to Propionibacterium acnes, but its role of immunoregulation is drawing people's attention. In this work, based on the role of macrophages in removal of pathogenic bacteria as a primary scavenger and particulate antigen-presenting cell, the stimulation of macrophages by C. pyruviciproducens was analyzed through detecting the levels of cytokine secretion and expression of membrane molecules, and the effect of C. pyruviciproducens in promoting antibody response to sheep red blood cells (SRBC) in vivo was detected. In vitro, C. pyruviciproducens led to a sharp release of interleukin-6 and tumour necrosis factor-α and encouraged the activation of macrophages including enhanced expressions of MHC-II, CD40, CD80 and CD86. In vivo, it enhanced the humoral immune response against SRBC, a particulate antigen. These observations suggest that C. pyruviciproducens, as an immunoregulator, can promote the host humoral immune response to pathogenic microorganisms by regulating macrophage function.
authors.affiliation: Department of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Tong
authors.forename: Qingzhen
authors.initials: Q
authors.lastname: Han
authors.forename: Shengjun
authors.initials: S
authors.lastname: Wang
authors.forename: Zhaoliang
authors.initials: Z
authors.lastname: Su
authors.forename: Dong
authors.initials: D
authors.lastname: Zheng
authors.forename: Pei
authors.initials: P
authors.lastname: Shen
authors.forename: Sheng
authors.initials: S
authors.lastname: Xia
authors.forename: Xinxiang
authors.initials: X
authors.lastname: Huang
authors.forename: Qixiang
authors.initials: Q
authors.lastname: Shao
authors.forename: Huaxi
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000382:microbiology; D000941:Antigens / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology; D048708:Cell Growth Processes / Q000276:immunology; D002460:Cell Line; D003352:Corynebacterium / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D056724:Immunity, Humoral / Q000276:immunology; D007155:Immunologic Factors / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D012756:Sheep; D018418:Th2 Cells / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D015854:Up-Regulation / Q000276:immunology
chemical_list: D000941:Antigens; D015703:Antigens, CD; D007155:Immunologic Factors; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha