title: [Electrophysiological effects and antiarrhythmic activity of novel domestic class III antiarrhythmogenic drug niferidil administered in patients with paroxismal supraventricular tachycardia].
abstract: Intracardiac electrophysiological effects and antiarrhythmic activity of novel domestic class III antiarrhythmogenic drug niferidil has been studied in a group of 25 patients with paroxismal supraventricular tachycardia (PSVT) diagnosis. The drug was administered in a dose of 20 mg/kg (i.v.). Niferidil injections increased the refractory periods in both right and left atrium (by 22 and 20%, respectively, p < 0.001), right ventricle (12%, p < 0.01), and the His-Purkinje system (34%, p < 0.001) and improved additional anterograde and retrograde conduction (by 22 and 31%, respectively, p < 0.001), while not influencing the conduction via excitable cardiac tissues. Elongation of the QTc interval (22%, p <0.05) in one case was accompanied by an arrythmogenic effect (induction of short-term polymorphous ventricular tachycardia of the "torsade de pointes" type. Niferidil arrested PSVT in 78% cases and prevented PSVT development in response to endocardial stimulation in 86% of patients.
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Mironov
authors.forename: S P
authors.initials: SP
authors.lastname: Golitsyn
authors.forename: S F
authors.initials: SF
authors.lastname: Sokolov
authors.forename: E B
authors.initials: EB
authors.lastname: Maĭkov
authors.forename: N B
authors.initials: NB
authors.lastname: Shlevkov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Iuricheva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Mareev
authors.forename: L V
authors.initials: LV
authors.lastname: Rosenshtraukh
authors.forename: E I
authors.initials: EI
authors.lastname: Chazov
mesh_terms: D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage*; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy* / Q000503:physiopathology*; D013617:Tachycardia, Supraventricular / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D000889:Anti-Arrhythmia Agents; D010880:Piperidines; C578899:niferidil