title: Role of pituitary dysfunction on cardiovascular risk in primary empty sella patients.
abstract: OBJECTIVE
  Primary empty sella (PES) is a frequent anatomical condition rarely causing pituitary dysfunction. We assessed cardiovascular risk in a cohort of PES patients referred to Endocrine Units.
  
  
  METHODS
  The study was performed in three Italian tertiary referral centres. We evaluated pituitary function and cardiovascular risk, on the basis of lipid and glucose metabolism parameters and of Framingham score (FS), in 94 consecutive patients with PES diagnosis and in 94 gender, age and BMI matched controls.
  
  
  METHODS
  Pituitary function was normal in 30 patients (group A), whereas a single or multiple pituitary hormone deficiency was demonstrated in 64 (group B). Growth hormone deficiency (GHD) was diagnosed in 56, central hypothyroidism in 35, hypogonadotropic hypogonadism in 32 and central hypoadrenalism in 24 cases.
  
  
  RESULTS
  Framingham score was higher and glucose and lipid profile were worse in PES patients than in controls. Cardiovascular risk parameters were not different between group A and B. In group B, increased cardiovascular risk was associated with hypothyroidism and hypogonadism, but not with GHD. In group A, cardiovascular risk was higher and FT3 and FT4 levels were lower than in controls. Moreover, PES patients stratified for BMI showed a worse glucose and lipid profile and (in the overweight subgroup) higher FS than matched controls.
  
  
  CONCLUSIONS
  Primary empty sella patients show increased cardiovascular risk, regardless of BMI. A worse lipid and glucose profile and higher FS were associated with secondary hypothyroidism, even subclinical, as well as hypogonadism.
authors.affiliation: Department of Endocrinology and Molecular Oncology, University Federico II of Naples, Naples, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.forename: Oana R
authors.initials: OR
authors.lastname: Cotta
authors.forename: Diego
authors.initials: D
authors.lastname: Ferone
authors.forename: Maria L
authors.initials: ML
authors.lastname: Torre
authors.forename: Francesco
authors.initials: F
authors.lastname: Ferraù
authors.forename: Carolina
authors.initials: C
authors.lastname: Di Somma
authors.forename: Mara
authors.initials: M
authors.lastname: Boschetti
authors.forename: Claudia
authors.initials: C
authors.lastname: Teti
authors.forename: Maria C
authors.initials: MC
authors.lastname: Savanelli
authors.forename: Angela
authors.initials: A
authors.lastname: Alibrandi
authors.forename: Francesco
authors.initials: F
authors.lastname: Trimarchi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cannavò
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology*; D004652:Empty Sella Syndrome / Q000150:complications*; D005260:Female; D005947:Glucose / Q000378:metabolism; D019382:Human Growth Hormone / Q000172:deficiency; D006801:Humans; D007018:Hypopituitarism / Q000150:complications*; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000503:physiopathology*; D012307:Risk Factors
chemical_list: D019382:Human Growth Hormone; D005947:Glucose