title: Possible role of insulin-like factor 3 in the bovine corpus luteum.
abstract: Insulin-like factor 3 (INSL3) is a local regulator in mammalian gonads, but little is known of its function in bovine corpus luteum (CL). Here, we show that RXFP2 protein, the receptor of INSL3, was expressed throughout the estrous cycle and significantly high at the early luteal stage compared to the regressed luteal stage. INSL3 stimulated progesterone secretion, but not prostaglandin F2α and viability in cultured luteal cells. Together, these results suggest that INSL3 plays a luteotropic role as a local regulator in the bovine CL.
authors.affiliation: Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
authors.forename: Misato
authors.initials: M
authors.lastname: Abe
authors.forename: Takuo
authors.initials: T
authors.lastname: Hojo
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kozai
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Okuda
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002417:Cattle; D003338:Corpus Luteum; D030762:Estrous Cycle / Q000378:metabolism*; D005260:Female; D007328:Insulin / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D007328:Insulin; C084797:Leydig insulin-like protein; D011506:Proteins; D043562:Receptors, G-Protein-Coupled; D011374:Progesterone