title: Initial choice of therapy among plenty for newly diagnosed chronic myeloid leukemia.
abstract: Imatinib has been the preferred initial therapy for newly diagnosed chronic myeloid leukemia patients for the past 10 years. Recently, other, possibly better, tyrosine kinase inhibitors have been licensed for first-line use based on the early results of 2 large, randomized clinical trials. The pros and cons of the various alternatives to imatinib are analyzed herein, and I try to answer the question of are we ready to abandon imatinib and, if yes, then what treatment should a patient diagnosed today receive.
authors.affiliation: Hammersmith Hospital, Imperial College London, London, United Kingdom. d.marin@imperial.ac.uk
authors.forename: David
authors.initials: D
authors.lastname: Marin
mesh_terms: D000814:Aniline Compounds / Q000627:therapeutic use; D001549:Benzamides / Q000627:therapeutic use; D000069439:Dasatinib; D006801:Humans; D000068877:Imatinib Mesylate; D016898:Interferon-alpha / Q000378:metabolism; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000188:drug therapy*; D008495:Medical Oncology / Q000379:methods*; D009570:Nitriles / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D011804:Quinolines / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D033581:Stem Cell Transplantation; D013844:Thiazoles / Q000627:therapeutic use; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D000814:Aniline Compounds; D001549:Benzamides; D016898:Interferon-alpha; D009570:Nitriles; D010879:Piperazines; D011743:Pyrimidines; D011804:Quinolines; D013844:Thiazoles; C471992:bosutinib; D000068877:Imatinib Mesylate; C498826:nilotinib; D000069439:Dasatinib