title: [Contemporary trends of genetic analysis in hypertrophic cardiomyopathy].
abstract: Subject of great interest of contemporary scientific community is a search for additional genetic and environmental factors which are capable to influence formation of a clinical variant of the course of hypertrophic cardiomyopathy (HCMP). It has been shown by many works that besides mutations in genes of sarcomere proteins clinical course of HCMP is also affected by modifier genes of the cardiovascular system such as association of polymorphisms RAAS, sympathoadrenal system, NO-synthase, endothelin system, and system of blood coagulation. Attempts have been made to study effects of these polymorphisms on formation of clinical variant of HCMP course and to search for associations with development of unfavorable variants.
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Belenkov
authors.forename: E V
authors.initials: EV
authors.lastname: Privalova
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Kaplunova
authors.forename: N V
authors.initials: NV
authors.lastname: Khabarova
authors.forename: G A
authors.initials: GA
authors.lastname: Shakar'iants
mesh_terms: D001777:Blood Coagulation / Q000235:genetics; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D004452:Echocardiography; D059647:Gene-Environment Interaction; D060045:Genes, Modifier; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D020412:Multifactorial Inheritance; D009154:Mutation; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D052250:Nitric Oxide Synthase Type III / Q000235:genetics; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics; D012518:Sarcomeres / Q000235:genetics*
chemical_list: D052250:Nitric Oxide Synthase Type III