title: Central nervous system complications and neuroradiological findings in children with chronic active Epstein-Barr virus infection.
abstract: BACKGROUND
  Although many neurological complications have been described in acute Epstein-Barr virus infection, few reports have discussed the central nervous system complications in chronic active Epstein-Barr virus (CAEBV) infection.
  
  
  METHODS
  We retrospectively surveyed the medical records of 14 patients with CAEBV infection in our institute. Neuroradiological studies were performed in 10 of these patients.
  
  
  RESULTS
  Five had no neurological symptoms, whereas two presented with posterior reversible encephalopathy syndrome, one presented with basal ganglia calcification, and one presented with falx cerebri hemorrhage. Although both of the posterior reversible encephalopathy syndrome cases developed epilepsy several years after recovering from prolonged neurological deterioration, the others had no neurological sequelae.
  
  
  CONCLUSIONS
  This study revealed that various central nervous system complications may occur during the clinical course in pediatric CAEBV patients.
authors.affiliation: Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. ishikan@hiroshima-u.ac.jp
authors.forename: Nobutsune
authors.initials: N
authors.lastname: Ishikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakamura
authors.forename: Masao
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D001480:Basal Ganglia Diseases / Q000175:diagnosis / Q000821:virology*; D002114:Calcinosis / Q000175:diagnosis / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D018450:Disease Progression; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006408:Hematoma, Subdural / Q000175:diagnosis / Q000821:virology*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D054038:Posterior Leukoencephalopathy Syndrome / Q000175:diagnosis / Q000821:virology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed