title: Polycystic ovarian syndrome in patients with lipodystrophy: Report of 2 cases with review of literature.
abstract: Lipodystrophy is a clinical disorder characterized by maldistribution of body fat. Hyperinsulinemia, insulin resistance, and abnormalities of glucose homeostasis are commonly described among these patients. Hyperinsulinemia is also involved in the pathogenesis of polycystic ovarian syndrome, a condition, described rarely in patients with lipodystrophy. Here, we describe 2 females of partial lipodystrophy who presented with features of polycystic ovarian disease. Both had severe hyperinsulinemia and irregular periods, one had hyperandrogenism and hirsuitism while the other was non-hirsuite.
authors.affiliation: Department of Endocrinology, Dr. Ram Manohar Lohia Hospital, New Delhi, India.
authors.forename: Isha
authors.initials: I
authors.lastname: Pahuja
authors.forename: Prasanjit
authors.initials: P
authors.lastname: De
authors.forename: Neera
authors.initials: N
authors.lastname: Sharma
authors.forename: Bindu
authors.initials: B
authors.lastname: Kulshreshtha