title: Antiviral activity of (+)-sattabacin against varicella zoster.
abstract: The first report of the antiviral activity of (+)-sattabacin against varicella-zoster virus (VZV) is described. Our results show that (+)-sattabacin potently inhibits the growth of VZV at concentrations in the range of other drugs commonly prescribed for VZV infection. Experiments detailing the synthesis of (+)-sattabacin, quantification of cytotoxicity and gene expression data in human fibroblast cells are also presented. Gene expression data was obtained through microarray analysis from human fibroblast cells exposed to sattabacin in order to identify a possible mechanism by which (+)-sattabacin inhibits VZV replication.
authors.affiliation: Department of Biology, Fort Lewis College, 1000 Rim Drive, Durango, CO 81301, USA.
authors.forename: Serena R
authors.initials: SR
authors.lastname: Mancha
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Regnery
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Dahlke
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Miller
authors.forename: David J
authors.initials: DJ
authors.lastname: Blake
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D006588:Hexanones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure
chemical_list: D000998:Antiviral Agents; D006588:Hexanones; C096624:sattabacin