title: Immunology and clinical manifestations of non-clonal mast cell activation syndrome.
abstract: There is a spectrum of disorders that clinically manifest as a result of mast cell activation. A non-clonal form has emerged in the literature where many of the clinical features of systemic mastocytosis are shared despite having a distinct mast cell biology. In this review, we summarize key features of the science behind mast cell activation relevant to what is now known as non-clonal mast cell activation syndrome (nc-MCAS). We highlight the clinical manifestations of nc-MCAS with a focus on diagnosis and treatment.
authors.affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Juan-Carlos
authors.initials: JC
authors.lastname: Cardet
authors.forename: Mariana C
authors.initials: MC
authors.lastname: Castells
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Hamilton
mesh_terms: D000818:Animals; D006801:Humans; D008407:Mast Cells / Q000276:immunology*; D034721:Mastocytosis, Systemic / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy; D013577:Syndrome