title: Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones.
abstract: A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)(2) to afford pyrimidin-4-ones.
authors.affiliation: Department of Chemistry and Nano Science (BK21), Ewha Womans University, Seoul 120-750, Korea.
authors.forename: Yu Sung
authors.initials: YS
authors.lastname: Chun
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Suh Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Young Ok
authors.initials: YO
authors.lastname: Ko
authors.forename: Sang-gi
authors.initials: SG
authors.lastname: Lee