title: The emerging role of the mitochondrial-derived peptide humanin in stress resistance.
abstract: The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially new category of biologically active peptide. As more research unravels the endogenous role of humanin as well as its potential pharmacological use, its role in stress resistance has become clearer. Humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults in vitro and also improves cardiovascular disease as well as Alzheimer's disease in vivo. In this review, we discuss the emerging role of humanin in stress resistance and its proposed mechanism of action.
authors.affiliation: USC Davis School of Gerontology, University of Southern California, Los Angeles, California 90089-0191, USA.
authors.forename: Kelvin
authors.initials: K
authors.lastname: Yen
authors.forename: Changhan
authors.initials: C
authors.lastname: Lee
authors.forename: Hemal
authors.initials: H
authors.lastname: Mehta
authors.forename: Pinchas
authors.initials: P
authors.lastname: Cohen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism*; D008969:Molecular Sequence Data; D018384:Oxidative Stress; D011487:Protein Conformation; D015427:Reperfusion Injury / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C427211:humanin