title: IL-6 treatment increases the survival of retinal ganglion cells in vitro: the role of adenosine A1 receptor.
abstract: IL-6 is a pleiotropic cytokine classically denominated pro-inflammatory. It has been already demonstrated that IL-6 can increase the survival of retinal ganglion cells (RGC) in culture. In this work, we show that the trophic effect of IL-6 is mediated by adenosine receptor (A1R) activation. The neutralization of extracellular BDNF abolished the IL-6 effect and the treatment with IL-6 and CHA (an agonist of A1R) modulated BDNF expression as well as pCREB and pTrkB levels.
authors.affiliation: Departamento de Neurobiologia, Programa de Pós-Graduação em Neurociências, Instituto de Biologia, Universidade Federal Fluminense, Outeiro de São João Batista s/n, Niterói, Rio de Janeiro CEP 24020-140, Brazil.
authors.forename: Rafael
authors.initials: R
authors.lastname: Perígolo-Vicente
authors.forename: Karen
authors.initials: K
authors.lastname: Ritt
authors.forename: Mariana Rodrigues
authors.initials: MR
authors.lastname: Pereira
authors.forename: Patrícia Maria Mendonça
authors.initials: PM
authors.lastname: Torres
authors.forename: Roberto
authors.initials: R
authors.lastname: Paes-de-Carvalho
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Giestal-de-Araujo
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D058907:Adenosine A1 Receptor Agonists / Q000494:pharmacology; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D015850:Interleukin-6 / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D043682:Receptor, Adenosine A1 / Q000096:biosynthesis / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000187:drug effects* / Q000378:metabolism
chemical_list: D058907:Adenosine A1 Receptor Agonists; D019208:Brain-Derived Neurotrophic Factor; D015850:Interleukin-6; D043682:Receptor, Adenosine A1; D000241:Adenosine