title: Early neurodevelopment in very low birth weight infants with mild intraventricular hemorrhage or those without intraventricular hemorrhage.
abstract: OBJECTIVE
  This study aimed to assess early development in very low birth weight (VLBW) infants with mild intraventricular hemorrhage (IVH) or those without IVH and to identify the perinatal morbidities affecting early neurodevelopmental outcome.
  
  
  METHODS
  Bayley Scales of Infant Development-II was used for assessing neurological development in 49 infants with a birth weight <1,500 g and with low grade IVH (≤grade II) or those without IVH at a corrected age of 12 months.
  
  
  RESULTS
  Among the 49 infants, 19 infants (38.8%) showed normal development and 14 (28.6%) showed abnormal mental and psychomotor development. Infants with abnormal mental development (n=14) were mostly male and had a longer hospitalization, a higher prevalence of patent ductus arteriosus (PDA) and bronchopulmonary dysplasia (BPD), and were under more frequent postnatal systemic steroid treatment compared with infants with normal mental development (n=35, P<0.05). Infants with abnormal psychomotor development (n=29) had a longer hospitalization and more associated PDA compared to infants with normal psychomotor development (n=20, P<0.05). Infants with abnormal mental and psychomotor development were mostly male and had a longer hospitalization and a higher prevalence of PDA and BPD compared to infants with normal mental and psychomotor development (n=19, P<0.05). Using multiple logistic regression analysis, a longer duration of hospitalization and male gender were found to be significant risk factors.
  
  
  CONCLUSIONS
  Approximately 62% of VLBW infants with low grade IVH or those without IVH had impaired early development.
authors.affiliation: Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Il Rak
authors.initials: IR
authors.lastname: Choi
authors.forename: Jang Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Moon Sung
authors.initials: MS
authors.lastname: Park
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Kyu Hee
authors.initials: KH
authors.lastname: Park
authors.forename: Gun-Ha
authors.initials: GH
authors.lastname: Kim
authors.forename: So-Hee
authors.initials: SH
authors.lastname: Eun