title: Effects of dopaminergic and subthalamic stimulation on musical performance.
abstract: Although subthalamic-deep brain stimulation (STN-DBS) is an efficient treatment for Parkinson's disease (PD), its effects on fine motor functions are not clear. We present the case of a professional violinist with PD treated with STN-DBS. DBS improved musical articulation, intonation and emotional expression and worsened timing relative to a timekeeper (metronome). The same effects were found for dopaminergic treatment. These results suggest that STN-DBS, mimicking the effects of dopaminergic stimulation, improves fine-tuned motor behaviour whilst impairing timing precision.
authors.affiliation: Institute of Music Physiology and Musicians' Medicine, Hannover University of Music, Drama and Media, Hannover, Germany.
authors.forename: Floris T
authors.initials: FT
authors.lastname: van Vugt
authors.forename: Michael
authors.initials: M
authors.lastname: Schüpbach
authors.forename: Eckart
authors.initials: E
authors.lastname: Altenmüller
authors.forename: Eric
authors.initials: E
authors.lastname: Bardinet
authors.forename: Jérôme
authors.initials: J
authors.lastname: Yelnik
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Hälbig
mesh_terms: D000328:Adult; D001308:Auditory Perceptual Disorders / Q000209:etiology / Q000628:therapy*; D046690:Deep Brain Stimulation / Q000379:methods*; D015259:Dopamine Agents / Q000627:therapeutic use*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D009068:Movement / Q000187:drug effects; D009146:Music; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D020531:Subthalamic Nucleus / Q000502:physiology*; D013998:Time Perception / Q000187:drug effects / Q000502:physiology
chemical_list: D015259:Dopamine Agents; D007211:Indoles; C046649:ropinirole; D007980:Levodopa