title: Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β-Elemene.
abstract: In the past decade, β-elemene played an important role in enhancing the effects of many anticancer drugs and was widely used in the treatment of different kinds of malignancies and in reducing the side effects of chemotherapy. Further study showed that it is also a promising anti-lung cancer drug. However, the clinical application of β-elemene was limited by its hydrophobic property, poor stability, and low bioavailability. With the development of new excipients and novel technologies, plenty of novel formulations of β-elemene have improved dramatically, which provide a positive perspective in terms of clinical application for β-elemene. Liposome as a drug delivery system shows great advantages over traditional formulations for β-elemene. In this paper, we summarize the advanced progress being made in anti-lung cancer activity and the new liposomes delivery systems of β-elemene. This advancement is expected to improve the level of pharmacy research and provide a stronger scientific foundation for further study on β-elemene.
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
authors.forename: Meiwan
authors.initials: M
authors.lastname: Chen
authors.forename: Jinming
authors.initials: J
authors.lastname: Zhang
authors.forename: Siqin
authors.initials: S
authors.lastname: Yu
authors.forename: Shengpeng
authors.initials: S
authors.lastname: Wang
authors.forename: Zaijun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
authors.forename: Yitao
authors.initials: Y
authors.lastname: Wang