title: Baculovirus genes modulating intracellular innate antiviral immunity of lepidopteran insect cells.
abstract: Innate immunity is essential for insects to survive infectious pathogens. In baculovirus-infected lepidopteran cells, apoptosis and global protein synthesis shutdown are major mechanisms of intracellular innate immunity that inhibit viral replication. In contrast, baculoviruses have evolved diverse genes and mechanisms to counter the antiviral immunity activated in infected cells. In this review, we summarize the current knowledge of the cellular antiviral pathways and the baculovirus genes that modulate antiviral immunity. The studies highlighted illustrate a high degree of diversity in both the cellular responses against viral infections and viral responses against intracellular antiviral immunity, providing an important basis of further studies in this field.
authors.affiliation: Laboratory of Sericulture and Entomoresources, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. mochiko@agr.nagoya-u.ac.jp
authors.forename: Motoko
authors.initials: M
authors.lastname: Ikeda
authors.forename: Hayato
authors.initials: H
authors.lastname: Yamada
authors.forename: Rina
authors.initials: R
authors.lastname: Hamajima
authors.forename: Michihiro
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D017209:Apoptosis; D016367:Baculoviridae / Q000235:genetics* / Q000276:immunology*; D005814:Genes, Viral; D057131:Immune Evasion; D007113:Immunity, Innate; D007915:Lepidoptera / Q000276:immunology* / Q000821:virology*; D014176:Protein Biosynthesis; D014779:Virus Replication