title: A role for A-to-I RNA editing in temperature adaptation.
abstract: A-to-I RNA editing can recode mRNAs, giving organisms the option to express diverse, functionally distinct protein isoforms. Here, we propose that RNA editing is inherently geared for temperature adaptation because it tends to recode to smaller, less stabilizing amino acids. Studies on how editing affects protein function support this idea.
authors.affiliation: Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico. sandracoralgarrett@gmail.com
authors.forename: Sandra C
authors.initials: SC
authors.lastname: Garrett
authors.forename: Joshua J C
authors.initials: JJ
authors.lastname: Rosenthal
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics*; D000818:Animals; D006801:Humans; D020033:Protein Isoforms; D017393:RNA Editing; D012333:RNA, Messenger / Q000235:genetics*; D013696:Temperature
chemical_list: D020033:Protein Isoforms; D012333:RNA, Messenger