title: Prognostic significance of IDH1 mutations in acute myeloid leukemia: a meta-analysis.
abstract: Isocitrate dehydrogenase 1 (IDH1) gene aberrations have recently been reported in acute myeloid leukemia (AML). To evaluate the prognostic significance of IDH1 mutations in AML, we performed a meta-analysis. Fifteen studies covering a total of 8121 subjects were included in this analysis. The frequency of IDH1 R132 mutations were 4.4-9.3% for AML patients and 10.9-16.0% for cytogenetically normal (CN)-AML patients. The IDH1 mutations were associated with NPM1 mutations in 6 studies and normal cytogenetics in 5 studies. AML patients with IDH1 mutations had inferior overall survival compared to patients without the mutations (hazard ratio 1.17, 95% CI: 1.02-1.36). Additionally, in CN-AML patients, IDH1 mutations were associated with a lower complete remission rate (risk ratio 1.30, 95% CI: 1.04-1.63). Although the available literature is limited to observational studies, these results may justify the risk-adapted therapeutic strategies for AML according to the IDH1 status.
authors.affiliation: Division of Hematology-Oncology, and Key Laboratory of Reproductive Genetics (Zhejiang University, Ministry of Education), Children's Hospital, Zhejiang University School of Medicine Hangzhou 310003, PR China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Feng
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Guo
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Chen
authors.forename: Zhu-Jun
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Cheng
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Tang