title: [B lymphocyte stimulator in systemic lupus erythematosus].
abstract: The B lymphocyte stimulator (BLyS) is an essential protein for the growth and survival of B cells. BLyS is expressed on monocytes, macrophages, and dendritic cells. BLyS binds to three receptors on B cells: BAFF-R, BCMA, and TACI. BLyS overexpression in mice leads to lupus-like syndrome, but not in all, whereas BLyS deficient mice results in a block of B cell development. High serum levels of BLyS can be detected in patients with lupus and rheumatoid arthritis. BLyS antagonists are an attractive target for treating autoimmune diseases.
authors.forename: Ulises
authors.initials: U
authors.lastname: Mercado
mesh_terms: D053264:B-Cell Activating Factor / Q000502:physiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
chemical_list: D053264:B-Cell Activating Factor