title: Assessment of the correlation between TIMP4 SNPs and schizophrenia and             autism spectrum disorders.
abstract: Tissue inhibitors of metalloproteinases (TIMPs) are involved in synaptic plasticity, neuronal cell differentiation and neuroprotection in the central nervous system. To investigate whether TIMP4 polymorphisms are associated with schizophrenia and autism spectrum disorders (ASDs), 480 patients (schizophrenia, n=287; ASDs, n=193) and 296 controls were enrolled. Clinical symptoms of schizophrenia and ASDs were assessed using the operation criteria checklist for psychotic illness (OPCRIT) and Childhood Autism Rating Scale (CARS), respectively. One promoter single nucleotide polymorphism (SNP; rs3755724, -55C/T) and one exonic SNP (rs17035945, 3'-untranslated region) were selected. SNPStats and SNPAnalyzer Pro programs were used to calculate odds ratios. Multiple logistic regression models were performed to analyze the genetic data. Based on the results, these two SNPs were not associated with schizophrenia and ASD. In the analysis of clinical features of schizophrenia, rs3755724 was nominally associated with schizophrenia with poor concentration (P=0.044 in the codominant2 model, P=0.041 in the log-additive model and P=0.043 in allele frequency). These results suggest that TIMP4 is not associated with the development of schizophrenia and ASD in the population studied.
authors.affiliation: Department of Clinical Pharmacology, School of Medicine, Kyung                     Hee University, Seoul 130-702, Republic of Korea.
authors.forename: Sung-Vin
authors.initials: SV
authors.lastname: Yim
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Jeon
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Jo
authors.forename: Won Sub
authors.initials: WS
authors.lastname: Kang
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Lee
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000235:genetics*; D005091:Exons; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012559:Schizophrenia / Q000235:genetics*; D019714:Tissue Inhibitor of Metalloproteinases / Q000235:genetics*; D055815:Young Adult; D000097792:Tissue Inhibitor of Metalloproteinase-4
chemical_list: D019714:Tissue Inhibitor of Metalloproteinases; D000097792:Tissue Inhibitor of Metalloproteinase-4