title: Primary hyperparathyroidism is associated with abnormal cortical and trabecular microstructure and reduced bone stiffness in postmenopausal women.
abstract: Typically, in the milder form of primary hyperparathyroidism (PHPT), now seen in most countries, bone density by dual-energy X-ray absorptiometry (DXA) and detailed analyses of iliac crest bone biopsies by histomorphometry and micro-computed tomography (µCT) show detrimental effects in cortical bone, whereas the trabecular site (lumbar spine by DXA) and the trabecular compartment (by bone biopsy) appear to be relatively well preserved. Despite these findings, fracture risk at both vertebral and nonvertebral sites is increased in PHPT. Emerging technologies, such as high-resolution peripheral quantitative computed tomography (HRpQCT), may provide additional insight into microstructural features at sites such as the forearm and tibia that have heretofore not been easily accessible. Using HRpQCT, we determined cortical and trabecular microstructure at the radius and tibia in 51 postmenopausal women with PHPT and 120 controls. Individual trabecula segmentation (ITS) and micro-finite element (µFE) analyses of the HRpQCT images were also performed to further understand how the abnormalities seen by HRpQCT might translate into effects on bone strength. Women with PHPT showed, at both sites, decreased volumetric densities at trabecular and cortical compartments, thinner cortices, and more widely spaced and heterogeneously distributed trabeculae. At the radius, trabeculae were thinner and fewer in PHPT. The radius was affected to a greater extent in the trabecular compartment than the tibia. ITS analyses revealed, at both sites, that plate-like trabeculae were depleted, with a resultant reduction in the plate/rod ratio. Microarchitectural abnormalities were evident by decreased plate-rod and plate-plate junctions at the radius and tibia, and rod-rod junctions at the radius. These trabecular and cortical abnormalities resulted in decreased whole-bone stiffness and trabecular stiffness. These results provide evidence that in PHPT, microstructural abnormalities are pervasive and not limited to the cortical compartment, which may help to account for increased global fracture risk in PHPT.
authors.affiliation: Metabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: Emily M
authors.initials: EM
authors.lastname: Stein
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Silva
authors.forename: Stephanie
authors.initials: S
authors.lastname: Boutroy
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Ji
authors.initials: J
authors.lastname: Wang
authors.forename: Julia
authors.initials: J
authors.lastname: Udesky
authors.forename: Chiyuan
authors.initials: C
authors.lastname: Zhang
authors.forename: Donald J
authors.initials: DJ
authors.lastname: McMahon
authors.forename: Megan
authors.initials: M
authors.lastname: Romano
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Dworakowski
authors.forename: Aline G
authors.initials: AG
authors.lastname: Costa
authors.forename: Natalie
authors.initials: N
authors.lastname: Cusano
authors.forename: Dinaz
authors.initials: D
authors.lastname: Irani
authors.forename: Serge
authors.initials: S
authors.lastname: Cremers
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Shane
authors.forename: X Edward
authors.initials: XE
authors.lastname: Guo
authors.forename: John P
authors.initials: JP
authors.lastname: Bilezikian
mesh_terms: D000368:Aged; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000473:pathology*; D017698:Postmenopause; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography