title: The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility.
abstract: MTDH (metadherin), an important oncogene that is widely overexpressed in various cancers, is a potential biomarker of tumor malignancy. Variants in MTDH have been associated with susceptibility to breast cancer. However, no studies assessing MTDH gene polymorphisms and their potential relationship to ovarian cancer susceptibility have been reported. Thus, we investigated the association of MTDH (-470G>A) polymorphism with ovarian cancer development in 145 ovarian cancer patients and 254 matched control subjects, using sequence analysis. We found that the MTDH (-470G>A) polymorphism was statistically correlated with ovarian cancer risk (under the additive genetic model, GG vs. GA vs AA, P = 0.042). Compared with genotypes containing the G allele (GG and GA), the AA genotype may decrease the risk of ovarian cancer (P = 0.0198, OR = 0.33, 95% CI [0.12∼0.78]). Compared with the G allele, the A allele is protective against ovarian cancer risk (P = 0.01756, OR = 0.66, 95% CI [0.46∼0.93]). Furthermore, a statistically significant association between the GG and GA+AA genotypes and the clinical stage was observed (P = 0.038). These data suggest that MTDH (-470G>A) could be a useful molecular marker for assessing ovarian cancer risk and for predicting ovarian cancer patient prognosis.
authors.affiliation: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji'nan, Shandong, China. yuancunzhong@126.com
authors.forename: Cunzhong
authors.initials: C
authors.lastname: Yuan
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.forename: Shi
authors.initials: S
authors.lastname: Yan
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Yang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liu
authors.forename: Beihua
authors.initials: B
authors.lastname: Kong
mesh_terms: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008565:Membrane Proteins; D010051:Ovarian Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016601:RNA-Binding Proteins; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins