title: [Rituximab as rescue therapy in refractory esophageal lichen planus].
abstract: Esophageal lichen planus (ELP) is a rare condition with unknown prevalence that can sometimes be underestimated due to the subtle and nonspecific findings of diagnostic workup. Oral lesions rarely extend to the esophageal mucosa, but when they do, the most frequent symptoms are dysphagia and odynophagia. There is often a significant delay in diagnosis and inadequate treatment. We report the case of a 59-year-old woman diagnosed with ELP, successfully treated with rituximab, a chimeric monoclonal antibody that depletes CD20+B cells. To our knowledge, this is only the second report of this treatment in ELP.
authors.affiliation: Servicio de Aparato Digestivo, Hospital de Zumárraga, Guipúzcoa, España. sgesarte@hotmail.com
authors.forename: Silvia
authors.initials: S
authors.lastname: Goñi Esarte
authors.forename: Antonio
authors.initials: A
authors.lastname: Arín Letamendía
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Vila Costas
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Jiménez Pérez
authors.forename: David
authors.initials: D
authors.lastname: Ruiz-Clavijo García
authors.forename: Juan
authors.initials: J
authors.lastname: Carrascosa Gil
authors.forename: María Luz
authors.initials: ML
authors.lastname: Almendral López
mesh_terms: D000505:Alopecia / Q000150:complications; D000730:Androstadienes / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D001284:Atrophy; D004935:Esophageal Diseases / Q000150:complications / Q000188:drug therapy*; D004940:Esophageal Stenosis / Q000209:etiology; D004942:Esophagitis, Peptic / Q000150:complications / Q000188:drug therapy; D004947:Esophagus / Q000473:pathology; D005260:Female; D000068298:Fluticasone; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008010:Lichen Planus / Q000150:complications / Q000188:drug therapy*; D017676:Lichen Planus, Oral / Q000150:complications; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D000069283:Rituximab; D016879:Salvage Therapy; D016176:T-Lymphocyte Subsets / Q000276:immunology; D007724:Vulvar Lichen Sclerosus / Q000150:complications
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D058846:Antibodies, Monoclonal, Murine-Derived; D007166:Immunosuppressive Agents; D054328:Proton Pump Inhibitors; D000069283:Rituximab; D000068298:Fluticasone; D011241:Prednisone