title: (±)-Tylopilusins, diphenolic metabolites from the fruiting bodies of Tylopilus eximius.
abstract: Racemates of the diphenolic metabolites (±)-tylopilusin A (1) and (±)-tylopilusin B (2) were isolated from the fruiting bodies of Tylopilus eximius. Their structures were elucidated on the basis of spectroscopic analyses (1D and 2D NMR data and ROESY correlations) and X-ray crystallography. Each racemate was separated into its individual enantiomers, and electronic circular dichroism calculations were used to assign the absolute configuration of (+)- and (-)-tylopilusin A (1) and (+)- and (-)-tylopilusin B (2).
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Tokyo 108-8641, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuda
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Nagai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D018360:Crystallography, X-Ray; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D007564:Japan; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D010636:Phenols; C578641:tylopilusin A