title: Precision of a new Scheimpflug and Placido-disk analyzer in measuring corneal thickness and agreement with ultrasound pachymetry.
abstract: OBJECTIVE
  To assess the precision of corneal thickness measurements obtained by a new Scheimpflug camera combined with Placido-disk corneal topography (Sirius) and compare the measured values with those obtained by ultrasound (US) pachymetry.
  
  
  METHODS
  Eye Hospital of Wenzhou Medical College, Wenzhou, China.
  
  
  METHODS
  Comparative evaluation of a diagnostic test or technology.
  
  
  METHODS
  Eyes of healthy subjects were examined with the Scheimpflug-Placido topographer. Central (CCT) and thinnest (TCT) corneal thickness were recorded after 3 consecutive measurements. For US pachymetry, only CCT was measured. Measurements were repeated within 1 week. The within-subject standard deviation (S(w)), test-retest repeatability, coefficient of variation (CoV), and intraclass correlation coefficient (ICC) were calculated to evaluate intrasession repeatability and intersession reproducibility. Interdevice comparison was analyzed with paired t tests and Bland-Altman plots.
  
  
  RESULTS
  The intrasession repeatability of Scheimpflug-Placido measurements was high, with test-retest and CoV close to 9 μm and 0.6% for CCT and TCT, respectively. The intersession test-retest and CoV were close to 10 μm and 0.7%, respectively. The ICC was higher than 0.98 for repeatability and reproducibility. High agreement was found between Scheimpflug-Placido and US pachymetry measurements, with narrow 95% limits of agreement.
  
  
  CONCLUSIONS
  The Scheimpflug-Placido instrument showed excellent intrasession repeatability and intersession reproducibility of CCT and TCT measurements in healthy eyes. High agreement and lack of statistically significant difference suggest that the instrument's TCT and the US pachymetry-CCT measurements can be used interchangeably in subjects with normal corneal thickness.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China.
authors.forename: Jinhai
authors.initials: J
authors.lastname: Huang
authors.forename: Giacomo
authors.initials: G
authors.lastname: Savini
authors.forename: Liang
authors.initials: L
authors.lastname: Hu
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Hoffer
authors.forename: Weicong
authors.initials: W
authors.lastname: Lu
authors.forename: Yifan
authors.initials: Y
authors.lastname: Feng
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
authors.forename: Xiuli
authors.initials: X
authors.lastname: Hu
authors.forename: Qinmei
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000328:Adult; D003315:Cornea / Q000033:anatomy & histology*; D063171:Corneal Pachymetry / Q000379:methods*; D019781:Corneal Topography / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D010781:Photography / Q000295:instrumentation*; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D015203:Reproducibility of Results; D055815:Young Adult