title: Effects of maternal smoking on fetal organs.
abstract: BACKGROUND
  Unfavorable effects of in-utero smoke exposure have been shown in several studies.
  
  
  OBJECTIVE
  In this experimental study, the authors aimed at showing detrimental effects of cigarette smoke on fetal tissues by assessing apoptosis that is detected by performing TUNEL staining.
  
  
  METHODS
  Designed groups were smoke exposed rats before and during pregnancy and control groups. Rat offsprings were sacrificed when they were 12 days old.
  
  
  RESULTS
  Lung, kidney, adrenal and gonad tissues were harvested for histopathologic analysis and assessed by TUNEL (Terminal dUTP Nick End Labeling) staining.
  
  
  CONCLUSIONS
  Smoke exposure caused increased apoptotic activity in lung parenchyma of study groups.
authors.affiliation: Gulhane Military Medical Faculty, Department of Pediatrics, Ankara, Turkey. akaraoglu@gata.edu.tr
authors.forename: Abdulbaki
authors.initials: A
authors.lastname: Karaoglu
authors.forename: Turan
authors.initials: T
authors.lastname: Tunc
authors.forename: Gokhan
authors.initials: G
authors.lastname: Aydemir
authors.forename: Onder
authors.initials: O
authors.lastname: Ongoru
authors.forename: Secil
authors.initials: S
authors.lastname: Aydinoz
authors.forename: Bulent
authors.initials: B
authors.lastname: Uysal
authors.forename: Galip
authors.initials: G
authors.lastname: Erdem
authors.forename: Ahmet
authors.initials: A
authors.lastname: Guven
authors.forename: Emin
authors.initials: E
authors.lastname: Oztas
authors.forename: S Umit
authors.initials: SU
authors.lastname: Sarici
mesh_terms: D000818:Animals; D017209:Apoptosis; D005260:Female; D020287:In Situ Nick-End Labeling; D018811:Maternal Exposure; D011247:Pregnancy; D051381:Rats; D012907:Smoking