title: Flavin-dependent enzymes in cancer prevention.
abstract: Statistical studies have demonstrated that various agents may reduce the risk of cancer's development. One of them is activity of flavin-dependent enzymes such as flavin-containing monooxygenase (FMO)(GS-OX1), FAD-dependent 5,10-methylenetetrahydrofolate reductase and flavin-dependent monoamine oxidase. In the last decade, many papers concerning their structure, reaction mechanism and role in the cancer prevention were published. In our work, we provide a more in-depth analysis of flavin-dependent enzymes and their contribution to the cancer prevention. We present the actual knowledge about the glucosinolate synthesized by flavin-containing monooxygenase (FMO)(GS-OX1) and its role in cancer prevention, discuss the influence of mutations in FAD-dependent 5,10-methylenetetrahydrofolate reductase on  the cancer risk, and describe FAD as an important cofactor for the demethylation of histons. We also present our views on the role of riboflavin supplements in the prevention  against cancer.
authors.affiliation: Department of Biochemistry, Faculty of Biology and Environmental Protection, University of Silesia in Katowice, Jagiellonska 28, 40-032 Katowice, Poland. urszula.guzik@us.edu.pl.
authors.forename: Danuta
authors.initials: D
authors.lastname: Wojcieszyńska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Hupert-Kocurek
authors.forename: Urszula
authors.initials: U
authors.lastname: Guzik
mesh_terms: D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2) / Q000378:metabolism*; D000818:Animals; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism; D006801:Humans; D008995:Monoamine Oxidase / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D012256:Riboflavin / Q000627:therapeutic use*; D012307:Risk Factors; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D009363:Neoplasm Proteins; D014803:Vitamin B Complex; D005182:Flavin-Adenine Dinucleotide; D008995:Monoamine Oxidase; D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2); D012256:Riboflavin