title: One-day core needle biopsy in a breast clinic: 4 years experience.
abstract: Many attempts have been made to combine the high diagnostic accuracy and conclusive rate of core needle biopsy (CNB) with the speed of fine needle aspiration cytology in evaluation of solid breast lesions. Multiple hybrid techniques have been developed to achieve this. We describe a cohort of patients for whom we used a relatively new, accelerated method of CNB processing, allowing for a definitive diagnosis the same day. All patients visiting the Radboud University Nijmegen Medical Centre breast clinic during a 4-year period were reviewed to identify all CNBs in this period performed in a same-day diagnosis track. CNB result was compared to post-operative pathology reports when available, and to follow-up when patients were not surgically treated. 1,060 patients underwent CNB of 1,383 lesions, 898 of which in a same-day diagnosis track with a sensitivity of 96.9 % and a specificity of 99.4 %. The inconclusive rate was 9.2 %. For a same-day diagnosis for solid breast lesions, we could give a conclusive diagnosis with accelerated CNB processing in 65 % of our patients requiring CNB. This technique can be used reliably in a same-day diagnosis breast clinic with a very high sensitivity, specificity, and conclusive rate.
authors.affiliation: Department of Surgery Oncology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, Post 690, P.O. Box 9101, 6500HB, Nijmegen, The Netherlands. jorisbulte@gmail.com
authors.forename: Joris P
authors.initials: JP
authors.lastname: Bulte
authors.forename: Lenny
authors.initials: L
authors.lastname: Polman
authors.forename: Margrethe
authors.initials: M
authors.lastname: Schlooz-Vries
authors.forename: Annelies
authors.initials: A
authors.lastname: Werner
authors.forename: Renate
authors.initials: R
authors.lastname: Besselink
authors.forename: Kelly
authors.initials: K
authors.lastname: Sessink
authors.forename: Roel
authors.initials: R
authors.lastname: Mus
authors.forename: Susanne
authors.initials: S
authors.lastname: Lardenoije
authors.forename: Mechli
authors.initials: M
authors.lastname: Imhof-Tas
authors.forename: Johan
authors.initials: J
authors.lastname: Bulten
authors.forename: Adriana C H
authors.initials: AC
authors.lastname: van Engen-van Grunsven
authors.forename: Ewout
authors.initials: E
authors.lastname: Schaafsma
authors.forename: Luc J A
authors.initials: LJ
authors.lastname: Strobbe
authors.forename: Peter
authors.initials: P
authors.lastname: Bult
authors.forename: Johannes H W
authors.initials: JH
authors.lastname: De Wilt
mesh_terms: D062005:Biopsy, Large-Core Needle; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors; D018084:Ultrasonography, Interventional / Q000379:methods