title: Cordyceps militaris extract attenuates D-galactose-induced memory impairment in mice.
abstract: Memory impairment is one of main clinical symptoms of brain senescence. To address the effects of Cordyceps militaris Link extract (CE) on memory impairment, a D-galactose (D-Gal)-induced aging mouse model was employed. Mice injected with D-Gal showed a significant learning and memory impairment that was rescued by CE treatment. The mechanism was further investigated by analyzing the protein level and activity of oxidant and antioxidant molecules, including malondialdehyde (MDA), monoamine oxidase (MAO), total super-oxide dismutase (T-SOD), total antioxidant capacity (T-AOC), glutathione (GSH), and glutathione peroxidase (GSH-px), which played critical roles in the development of brain senescence. The results showed that CE treatment resulted in a significant decrease in the oxidative activity of MAO and the level of MDA, and significantly increased the antioxidant activities of T-SOD and T-AOC in the cerebral cortices. Moreover, the level of GSH and the activity of antioxidant enzymes GSH-px in serum were significantly upregulated after CE treatment. Taken together, our results suggest that Cordyceps militaris extract could ameliorate experimental memory impairment in mice with D-Gal-induced aging through its potent antioxidant activities.
authors.affiliation: School of Chemistry and Pharmaceutical Engineering, University of Sichuan Science and Engineering, Zigong, China. lizaixin@sina.com
authors.forename: Zaixin
authors.initials: Z
authors.lastname: Li
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jinshan
authors.initials: J
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Jia
authors.forename: Jie
authors.initials: J
authors.lastname: Ding
authors.forename: Rongzhen
authors.initials: R
authors.lastname: Luo
authors.forename: Zhangqin
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000032:analysis; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D032661:Cordyceps / Q000737:chemistry*; D004195:Disease Models, Animal; D005260:Female; D005690:Galactose / Q000009:adverse effects*; D005978:Glutathione / Q000032:analysis; D005979:Glutathione Peroxidase / Q000032:analysis; D008315:Malondialdehyde / Q000032:analysis; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008995:Monoamine Oxidase / Q000032:analysis; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D013482:Superoxide Dismutase / Q000032:analysis; D015854:Up-Regulation
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase; D005978:Glutathione; D005690:Galactose