title: Not very funny: how a single mutation causes heritable bradycardia.
abstract: HCN channels and their modulation by cAMP play a key role in cardiac pacemaking. In this issue of Structure, Xu and colleagues reveal that an arrhythmia-causing mutation of an HCN channel weakens cAMP binding to the channel by altering the local structure of its entry-exit pathway.
authors.affiliation: Deparment of Biology and Health Sciences, Pace University, New York, NY 10038, USA. zburaei@pace.edu
authors.forename: Zafir
authors.initials: Z
authors.lastname: Buraei
authors.forename: Jian
authors.initials: J
authors.lastname: Yang