title: Clinical evaluation of pranoprofen combined with fluorometholone eye drops on postoperative reaction of corneal cross-linking.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL).
  
  
  METHODS
  Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases; 20 eyes). The patients in the control group were given fluorometholone eye drops, and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops．Corneal irritation and haze were compared between the two groups at 1 month postoperatively．
  
  
  RESULTS
  At 1 to 3 days after surgery, the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P<0.05), but there was no significant difference on 5 to 7 days postoperatively (P>0.05)．The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P<0.05), but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with P<20 mmHg intraocular pressure in the control group.
  
  
  CONCLUSIONS
  The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response, alleviate corneal irritation at early stage after CXL, effectively prevent and control the average of haze, and reduce the incidence of steroid-induced ocular hypertension after surgery．
authors.affiliation: 1.Cadet Corps, Postgraduate Medical School, PLA General Hospital, Beijing 100853, China  2.Department of ophthalmology, Navy General Hospital, Beijing 100048, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Pang
authors.forename: Zheng Jun
authors.initials: ZJ
authors.lastname: Fan
authors.forename: Xiu Jun
authors.initials: XJ
authors.lastname: Peng
authors.forename: Hong Zhen
authors.initials: HZ
authors.lastname: Jia
authors.forename: Teng Fei
authors.initials: TF
authors.lastname: Wu
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001578:Benzopyrans / Q000627:therapeutic use*; D003315:Cornea / Q000187:drug effects*; D003316:Corneal Diseases / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D058447:Eye Pain / Q000188:drug therapy*; D005469:Fluorometholone / Q000627:therapeutic use*; D006801:Humans; D007429:Intraocular Pressure; D007640:Keratoconus / Q000628:therapy*; D008297:Male; D009883:Ophthalmic Solutions; D010149:Postoperative Pain / Q000188:drug therapy*; D011184:Postoperative Period; D011422:Propionates / Q000627:therapeutic use*; D014466:Ultraviolet Rays; D014792:Visual Acuity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D009883:Ophthalmic Solutions; D011422:Propionates; C043940:pyranoprofen; D005469:Fluorometholone