title: Opioid-induced constipation.
abstract: Opioid-induced constipation is described, including features, mechanism, and management of the disorder. The role of various categories of laxatives including suppositories and the use of a peripherally acting μ-opioid receptor antagonist are discussed.
authors.affiliation: Pain and Palliative Care Service, Davidoff Center, Rabin Medical Center, Petach Tikvah, Israel. simonwe@clalit.org.il
authors.forename: Simon
authors.initials: S
authors.lastname: Wein
mesh_terms: D000285:Administration, Rectal; D000701:Analgesics, Opioid / Q000009:adverse effects*; D003248:Constipation / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D054368:Laxatives / Q000008:administration & dosage / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors; D013488:Suppositories
chemical_list: D000701:Analgesics, Opioid; D054368:Laxatives; D009292:Narcotic Antagonists; D017450:Receptors, Opioid, mu; D013488:Suppositories