title: Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications.
abstract: The costs associated with the treatment of medical device and surgical site infections are a major cause of concern in the global healthcare system. To prevent transmission of such infections, a prophylactic surface system that provides protracted release of antibacterial silver ions using low intensity direct electric current (LIDC; 28 μA system current at 6 V) activation has been recently developed. To ensure the safety for future in vivo studies and potential clinical applications, this study assessed the biocompatibility of the LIDC-activated interdigitated silver electrodes-based surface system; in vitro toxicity to human epidermal keratinocytes, human dermal fibroblasts, and normal human osteoblasts, and antibacterial efficacy against Staphylococcus aureus and Escherichia coli was evaluated. The study concluded that the technological applications of the surface system for medical devices and surgical tools, which contact human tissues for less than 1.5 h, are expected to be self-sterilizing without causing toxicity in vivo.
authors.affiliation: Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27607, USA.
authors.forename: Meghan E
authors.initials: ME
authors.lastname: Samberg
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Tan
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Monteiro-Riviere
authors.forename: Paul E
authors.initials: PE
authors.lastname: Orndorff
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Shirwaiker
mesh_terms: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004864:Equipment and Supplies; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D012834:Silver; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D012834:Silver