title: Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin.
abstract: Puerarin is a natural isoflavone, found in the Chinese medicinal plant Ge-gen, with many reported health-promoting properties. However, its low water solubility impedes its application in pharmaceutical and functional food products. This study explores the formation of inclusion complex between puerarin and glucosyl-β-cyclodextrin (G-β-CD) to improve the aqueous solubility of puerarin. The complex was prepared by mixing an equal molar mixture of puerarin and G-β-CD for 24 h, followed by freeze-drying. The obtained complex was analyzed by ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry, X-ray diffractometry, and proton nuclear magnetic resonance spectroscopy. Results showed clearly that the process led to the formation of a supramolecular complex in which the guest molecule, puerarin, was entrapped inside the cavity of the host, G-β-CD. The close association between puerarin and G-β-CD resulted in changes in some of the characteristic spectral, phase-transitional, and morphological properties of puerarin.
authors.affiliation: School of Food Science, Henan Institute of Science and Technology , Xinxiang 453003, People's Republic of China.
authors.forename: Benguo
authors.initials: B
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaoai
authors.initials: X
authors.lastname: Zhu
authors.forename: Jie
authors.initials: J
authors.lastname: Zeng
mesh_terms: D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical / Q000379:methods; D005612:Freeze Drying; D007529:Isoflavones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D044367:Phase Transition; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D007529:Isoflavones; D047392:beta-Cyclodextrins; D014867:Water; C033607:puerarin