title: Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region.
abstract: Different places may share common features, but are coded by distinct populations of CA3 neurons in the hippocampus. Here we show that chemical or genetic suppression of adult neurogenesis in the hippocampus impairs this population-based coding of similar (but not dissimilar) contexts. These data provide a neural basis for impaired spatial discrimination following ablation of adult neurogenesis, and support the proposal that adult neurogenesis regulates the efficiency of a pattern separation process in the hippocampus.
authors.affiliation: Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Niibori
authors.forename: Tzong-Shiue
authors.initials: TS
authors.lastname: Yu
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Epp
authors.forename: Katherine G
authors.initials: KG
authors.lastname: Akers
authors.forename: Sheena A
authors.initials: SA
authors.lastname: Josselyn
authors.forename: Paul W
authors.initials: PW
authors.lastname: Frankland
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D056654:CA3 Region, Hippocampal / Q000187:drug effects / Q000502:physiology*; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects / Q000502:physiology; D015774:Ganciclovir / Q000494:pharmacology; D006624:Hippocampus / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology*; D000077204:Temozolomide
chemical_list: D000477:Alkylating Agents; D003606:Dacarbazine; D015774:Ganciclovir; D000077204:Temozolomide