title: TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression.
abstract: BACKGROUND
  Serotonergic genes have been widely investigated regarding antidepressant response in major depressive disorder (MDD) but results are still not univocal.
  
  
  METHODS
  159 MDD patients treated with citalopram were genotyped and evaluated by the 21-item Hamilton Depression Rating Scale at the beginning and every 4 weeks during the 12-week follow-up. Four serotonin-related genetic variants were tested for association with treatment outcome: tryptophane hydroxylase 1 (TPH1) rs1800532, monoamine oxidase A µVNTR, serotonin 2A receptor rs6311 and serotonin 2C receptor rs6318. The effect of these polymorphisms was tested both in the whole sample and in depressive subtypes with usually higher clinical severity: psychotic and melancholic MDD.
  
  
  RESULTS
  No effect on response, remission and symptom improvement was found for the four polymorphisms. However, rs1800532 was found to affect the outcome depending on the MDD subtype: the A allele predicted worse response both in MDD with psychotic (F₆,₃₇₈ = 2.90; p = 0.009) and melancholic (F₆,₃₈₁ = 2.86; p = 0.0097) features.
  
  
  CONCLUSIONS
  The A allele at TPH1 rs1800532 may be associated with citalopram efficacy only in melancholic and psychotic MDD. These results suggest the usefulness of investigating the effect of genetic variants in conjunction with specific clinical features.
authors.affiliation: Unitat d'Antropologia, Departament de Biologia Animal, Facultat de Biologia and Institut de Biomedicina, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Arias
authors.forename: Chiara
authors.initials: C
authors.lastname: Fabbri
authors.forename: Florence
authors.initials: F
authors.lastname: Gressier
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Marina
authors.initials: M
authors.lastname: Mitjans
authors.forename: Cristóbal
authors.initials: C
authors.lastname: Gastó
authors.forename: Rosa
authors.initials: R
authors.lastname: Catalán
authors.forename: Diana
authors.initials: D
authors.lastname: De Ronchi
authors.forename: Lourdes
authors.initials: L
authors.lastname: Fañanás
mesh_terms: D000328:Adult; D000483:Alleles; D015283:Citalopram / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D016896:Treatment Outcome; D014365:Tryptophan Hydroxylase / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D015283:Citalopram; C497467:TPH1 protein, human; D014365:Tryptophan Hydroxylase; D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human