title: A multimodal approach to investigate biomarkers for psychosis in a clinical setting: the integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project.
abstract: Longitudinal clinical investigations and biological measurements have determined not only progressive brain volumetric and functional changes especially around the onset of psychosis but also the abnormality of developmental pathways based on gene-environment interaction model. However, these studies have contributed little to clinical decisions on their diagnosis and therapeutic choices because of subtle differences between patients and healthy controls. A multi-modal approach may resolve this limitation and is favorable to explore the pathophysiology of psychosis. The integrative neuroimaging studies for schizophrenia targeting early intervention and prevention (IN-STEP) is a research project aimed at exploring the pathophysiological features of the onset of psychosis and investigating possible predictive biomarkers for the clinical treatment of psychosis. Since 2008, we have adopted blood sampling, neurocognitive batteries, neurophysiological assessment, structural imaging, and functional imaging longitudinally for help-seeking ultra-high-risk (UHR) individuals and patients with first-episode psychosis (FEP). Here, we intend to introduce the IN-STEP research study protocol and present preliminary clinical findings. Thirty-seven UHR individuals and 30 patients with FEP participated in this study. Six months later, there was no difference in objective and subjective scores between the groups, which suggests that young people having symptoms and functional deficits should be cared for regardless of their history of psychosis according to their clinical stages. The rate of transition to psychosis was 7.1%, 8.0%, and 35.3% (at 6, 12, and 24months, respectively). Through this research project, we expect to clarify the pathophysiological features around the onset of psychosis and improve the prognosis of psychosis through clinical application.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, the University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan. skoike-tky@umin.ac.jp
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Koike
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Takano
authors.forename: Norichika
authors.initials: N
authors.lastname: Iwashiro
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Satomura
authors.forename: Motomu
authors.initials: M
authors.lastname: Suga
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nagai
authors.forename: Tatsunobu
authors.initials: T
authors.lastname: Natsubori
authors.forename: Mariko
authors.initials: M
authors.lastname: Tada
authors.forename: Yukika
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Syudo
authors.initials: S
authors.lastname: Yamasaki
authors.forename: Ryu
authors.initials: R
authors.lastname: Takizawa
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yahata
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Araki
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yamasue
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D015331:Cohort Studies; D018479:Early Intervention, Educational; D061345:Early Medical Intervention; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D019370:Observation; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology*; D015203:Reproducibility of Results; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy; D019265:Spectroscopy, Near-Infrared; D055815:Young Adult
chemical_list: D015415:Biomarkers