title: Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents.
abstract: As a part of our ongoing studies in developing new derivatives as dual antimicrobial/anti-inflammatory agents we describe the synthesis of novel 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones. All newly synthesized compounds were tested for their anti-inflammatory activity using carrageenan mouse paw edema bioassay. Their COX-1/LOX inhibitory activities were also determined. Moreover, all compounds were evaluated for their antimicrobial and antifungal activities against a panel of Gram positive, Gram negative bacteria and moulds. All tested compounds exhibited better antimicrobial activity than commercial drugs, bifonazole, ketoconazole, ampicillin and streptomycin.
authors.affiliation: Department of Pharmaceutical Chemistry of Aristotle University of Thessaloniki, School of Pharmacy, Thessaloniki 54124, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Apostolidis
authors.forename: K
authors.initials: K
authors.lastname: Liaras
authors.forename: A
authors.initials: A
authors.lastname: Geronikaki
authors.forename: D
authors.initials: D
authors.lastname: Hadjipavlou-Litina
authors.forename: A
authors.initials: A
authors.lastname: Gavalas
authors.forename: M
authors.initials: M
authors.lastname: Soković
authors.forename: J
authors.initials: J
authors.lastname: Glamočlija
authors.forename: A
authors.initials: A
authors.lastname: Ćirić
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D051545:Cyclooxygenase 1 / Q000737:chemistry / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000737:chemistry / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D013844:Thiazoles; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2