title: [Study on stability and cutaneous permeation kinetics in vitro of positive-ionized liposome gel containing paeonol].
abstract: OBJECTIVE
  To prepare positive-ionized liposome gel containing paeonol and study its stability and cutaneous permeation kinetics in vitro.
  
  
  METHODS
  Prepared the liposome gel by dispersion-ultrasonic and gridding method, and studied the stability with the impact factor experiments. Compared the permeation rate of liposome gel with conventional gel in vitro using the Franz-diffusion cell.
  
  
  RESULTS
  Mean diameter of the liposome was (132.7 +/- 14.1) nm with Zeta potential of (+33.54 +/- 1.95) mV and mean entrapment efficiency of (73.04 +/- 1.24)% (n=3), and the content of paeonol was (3.17 +/- 0.13) mg/g (n=3). The liposome gel had a promising appearance. It was stable at the humidity and the room temperature while was sensitive at the light and the temperature from 40 degrees C to 60 degrees C. The cumulative penetration amounts of the liposome gel was higher than that of the conventional gel (P < 0.05). Its cutaneous penetration rate and cumulative amounts in skin were higher than those of the conventional gel (P < 0.05).
  
  
  CONCLUSIONS
  The positive-ionized liposome gel containing paeonol is stable and feasibly prepared. It can enhance the cutaneous permeation efficiency and guarantee the persistent release rate.
authors.affiliation: School of Chinese Materia Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. shijun8008@163.com
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Xi-feng
authors.initials: XF
authors.lastname: Teng
authors.forename: Si-hang
authors.initials: SH
authors.lastname: Huang
mesh_terms: D000098:Acetophenones / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D000279:Administration, Cutaneous; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D005260:Female; D005782:Gels; D008081:Liposomes; D008297:Male; D051379:Mice; D010316:Particle Size; D010539:Permeability; D015203:Reproducibility of Results; D031364:Scutellaria baicalensis / Q000737:chemistry; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000098:Acetophenones; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D005782:Gels; D008081:Liposomes; C013638:paeonol