title: Palladium-catalyzed trifluoromethylation of aromatic C-H bond directed by an acetamino group.
abstract: The first palladium-catalyzed ortho-trifluoromethylation of the aromatic C-H bond directed by an acetamino group is reported. This method provides an efficient and green approach to synthesize the highly biological potential key structure of ortho-CF(3) acetanilides and anilines.
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS), College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871, China.
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Zhang
authors.forename: Kang
authors.initials: K
authors.lastname: Chen
authors.forename: Guihua
authors.initials: G
authors.lastname: Chen
authors.forename: Bi-Jie
authors.initials: BJ
authors.lastname: Li
authors.forename: Shuang
authors.initials: S
authors.lastname: Luo
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Guo
authors.forename: Jiang-Bo
authors.initials: JB
authors.lastname: Wei
authors.forename: Zhang-Jie
authors.initials: ZJ
authors.lastname: Shi
mesh_terms: D000083:Acetanilides / Q000138:chemical synthesis* / Q000737:chemistry; D000814:Aniline Compounds / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000083:Acetanilides; D000814:Aniline Compounds; D006845:Hydrocarbons, Fluorinated; D010165:Palladium