title: [A population genetic study of 22 autosomal loci of single nucleotide polymorphisms].
abstract: OBJECTIVE
  To evaluate polymorphisms and forensic efficiency of 22 non-binary single nucleotide polymorphism (SNP) loci.
  
  
  METHODS
  One hundred ethnic Han Chinese individuals were recruited from Dongguan, Guangdong. The 22 loci were genotyped with matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS).
  
  
  RESULTS
  Nine loci were found with a single allele, 4 loci were found to be biallelic, whilst 9 loci were found to have 3 alleles. For 13 polymorphic loci, the combined discrimination power and power of exclusion were 0.999 98 and 0.9330, respectively. For the 9 non-biallelic loci, the combined discrimination power and power of exclusion were 0.9998 and 0.8956, respectively. For motherless cases, the combined power of exclusion was 0.6405 for 13 polymorphic SNPs and 0.6405 for 9 non-binary SNPs.
  
  
  CONCLUSIONS
  Non-binary loci have a greater discrimination power and exclusion power per SNP.
authors.affiliation: Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing 100088, P R China. tangjianpin@hotmail.com
authors.forename: Jian-pin
authors.initials: JP
authors.lastname: Tang
authors.forename: Feng-hui
authors.initials: FH
authors.lastname: Jiang
authors.forename: Mei-sen
authors.initials: MS
authors.lastname: Shi
authors.forename: Chuan-chao
authors.initials: CC
authors.lastname: Xu
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
authors.forename: Xiao-pin
authors.initials: XP
authors.lastname: Lai
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D040741:Genetic Load; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide