title: [Role of antithrombin iii in cardiac surgery].
abstract: Coagulation of blood is of multidisciplinary interest. Cardiac surgery produces major changes in the delicate balance between pro-and anti-coagulant serum factors. The role of antithrombin iii has been analysed after finding evidence that associated decreased levels of protein activity to postoperative morbidity and mortality. Supplementing exogenous antithrombin is considered with the aim of optimising outcomes. Its intrinsic anticoagulant and anti-inflammatory properties have stimulated a growing interest, and suggests new lines of research.
authors.affiliation: Departamento de Anestesiología-Reanimación y Terapéutica del Dolor, Hospital Universitario La Ribera, Alzira, Valencia, España. Electronic address: vmuedra@hospital-ribera.com.
authors.forename: V
authors.initials: V
authors.lastname: Muedra
authors.forename: D
authors.initials: D
authors.lastname: Barettino
authors.forename: P
authors.initials: P
authors.lastname: D'Ocón
mesh_terms: D000990:Antithrombin III / Q000032:analysis / Q000502:physiology* / Q000627:therapeutic use; D020152:Antithrombin III Deficiency / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D006348:Cardiac Surgical Procedures; D005112:Extracorporeal Circulation / Q000009:adverse effects; D006801:Humans; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology
chemical_list: D000990:Antithrombin III