title: Photo-degradable, protein-polyelectrolyte complex-coated, mesoporous silica nanoparticles for controlled co-release of protein and model drugs.
abstract: The fabrication of photo-degradable, protein-polyelectrolyte complex (PPC)-coated, mesoporous silica nanoparticles (MSNs) and their controlled co-release of protein and model drugs is reported. Random copolymers composed of oligo(ethylene glycol) monomethyl ether methacrylate (OEGMA), and a photolabile o-nitrobenzyl-containing monomer, 5-(2'-(dimethylamino)ethoxy)-2-nitrobenzyl methacrylate (DENBMA), are first anchored onto the MSNs and then quaternary aminated, to obtain positively charged P(OEGMA-co-TENBMA) which exhibits photo-induced charge conversion characteristics. PPCs consisting of P(OEGMA-co-TENBMA) and the protein bovine serum albumin (BSA) are utilized as capping agents for the nanopores of the MSNs. Upon UV irradiation, charge conversion of P(OEGMA-co-TENBMA) can lead to the disruption of PPCs on MSNs and co-release of BSA and rhodamine B by electrostatic repulsion.
authors.affiliation: Institute of Advanced Materials, Graduate School at Shenzhen, Tsinghua University, P. R. China. wan.xuejuan@sz.tsinghua.edu.cn
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Wan
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Jinming
authors.initials: J
authors.lastname: Hu
authors.forename: Shiyong
authors.initials: S
authors.lastname: Liu
mesh_terms: D000818:Animals; D002417:Cattle; D004337:Drug Carriers / Q000737:chemistry*; D004573:Electrolytes / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010782:Photolysis; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011109:Polymethacrylic Acids; D016062:Porosity; D012235:Rhodamines / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D004337:Drug Carriers; D004573:Electrolytes; D008689:Methacrylates; D011108:Polymers; D011109:Polymethacrylic Acids; D012235:Rhodamines; C528061:poly(poly(ethylene glycol)methacrylate); D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; C029773:rhodamine B