title: Hydrophilic acrylic intraocular lens as a drug delivery system: influence of the presoaking time and comparison to intracameral injection.
abstract: OBJECTIVE
  To evaluate the influence of different intraocular lens (IOL) presoaking times in an antibiotic solution and to compare the results with intracameral antibiotic injection alone.
  
  
  METHODS
  Part A: 45 IOLs were soaked in gatifloxacin, moxifloxacin, or prednisolone acetate for 10 min, 24 h, and 1 week and then placed in a vial with a balanced salt solution. The solutions were sampled 12 and 24 h later. Part B: 90 eyes of 45 rabbits were divided into three groups. Group A received intracameral injection of moxifloxacin after lens removal and nonpresoaked IOL implantation. Groups B and C were implanted with IOLs that were presoaked for 15 min in moxifloxacin (group B) or gatifloxacin (group C), after lens removal with no intracameral antibiotic injections. Aqueous humor samples were taken 2, 4, 6, 8, and 10 h after surgery for high-performance liquid chromatography.
  
  
  RESULTS
  Part A: In comparison with the 24-h group, the 10-min group showed release of about 30% of the antibiotics amount; the 1-week group showed a longer release time of the antibiotics and an increase of 27% for gatifloxacin and 43% for moxifloxacin. No prednisolone acetate was found. Part B: The moxifloxacin concentrations in the intracameral injection group were higher after surgery, but with faster antibiotic decrease in comparison with both presoaked IOL groups.
  
  
  CONCLUSIONS
  Intracameral antibiotic injection showed a high antibiotic concentration for a short time. Presoaked IOLs showed slower decrease rates of the antibiotic level.
authors.affiliation: School of Medicine, Hebrew University and Hadassah, Jerusalem, Israel.
authors.forename: Inna
authors.initials: I
authors.lastname: Lipnitzki
authors.forename: Relli
authors.initials: R
authors.lastname: Bronshtein
authors.forename: Shmuel
authors.initials: S
authors.lastname: Ben Eliahu
authors.forename: Arie L
authors.initials: AL
authors.lastname: Marcovich
authors.forename: Guy
authors.initials: G
authors.lastname: Kleinmann
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001082:Aqueous Humor / Q000378:metabolism; D001372:Aza Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics; D000077734:Gatifloxacin; D057927:Hydrophobic and Hydrophilic Interactions; D056965:Injections, Intraocular; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D000077266:Moxifloxacin; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D011804:Quinolines / Q000008:administration & dosage / Q000493:pharmacokinetics; D011817:Rabbits; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; C009935:prednisolone acetate; D011239:Prednisolone; D000077734:Gatifloxacin; D000077266:Moxifloxacin