title: Glioblastoma, a brief review of history, molecular genetics, animal models and novel therapeutic strategies.
abstract: Glioblastoma (GBM) is the most common and lethal primary brain tumor. Over the past few years tremendous genomic and proteomic characterization along with robust animal models of GBM have provided invaluable data that show that "GBM", although histologically indistinguishable from one another, are comprised of molecularly heterogenous diseases. In addition, robust pre-clinical models and a better understanding of the core pathways disrupted in GBM are providing a renewed optimism for novel strategies targeting these devastating tumors. Here, we summarize a brief history of the disease, our current molecular knowledge, lessons from animal models and emerging concepts of angiogenesis, invasion, and metabolism in GBM that may lend themselves to therapeutic targeting.
authors.affiliation: Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto Medical Discovery Tower, Toronto, ON, Canada. Sameer.agnihotri@mail.utoronto.ca
authors.forename: Sameer
authors.initials: S
authors.lastname: Agnihotri
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Burrell
authors.forename: Amparo
authors.initials: A
authors.lastname: Wolf
authors.forename: Sharzhad
authors.initials: S
authors.lastname: Jalali
authors.forename: Cynthia
authors.initials: C
authors.lastname: Hawkins
authors.forename: James T
authors.initials: JT
authors.lastname: Rutka
authors.forename: Gelareh
authors.initials: G
authors.lastname: Zadeh
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000266:history; D004195:Disease Models, Animal; D005909:Glioblastoma / Q000188:drug therapy* / Q000235:genetics* / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D058990:Molecular Targeted Therapy / Q000639:trends; D009361:Neoplasm Invasiveness; D040901:Proteomics