title: A new rapid multicomponent domino heteroannulation of heterocyclic ketene aminals: solvent-free regioselective synthesis of functionalized benzo[g]imidazo[1,2-a]quinolinediones.
abstract: A highly efficient and straightforward three-component cascade reaction was developed to synthesize benzo[g]imidazo[1,2-a]quinolinedione derivatives from heterocyclic ketene aminals (HKAs), aldehydes, and 2-hydroxy-1,4-naphthoquinone (HNQ) via Et(3)N-catalyzed tandem [3 + 2 + 1] annulation under solvent-free conditions. The reactions were very mild, convenient and highly regioselective to form new fused tetracyclic target molecules.
authors.affiliation: State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China.
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Wen
authors.forename: Qi-Chang
authors.initials: QC
authors.lastname: Sun
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D000080:Acetals / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D005030:Ethylenes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000080:Acetals; D000588:Amines; D001555:Benzene Derivatives; D005030:Ethylenes; D007659:Ketones; D011804:Quinolines; C008223:ketene