title: SM2miR: a database of the experimentally validated small molecules' effects on microRNA expression.
abstract: The inappropriate expression of microRNAs (miRNAs) is closely related with disease diagnosis, prognosis and therapy response. Recently, many studies have demonstrated that bioactive small molecules (or drugs) can regulate miRNA expression, which indicates that targeting miRNAs with small molecules is a new therapy for human diseases. In this study, we established the SM2miR database, which recorded 2925 relationships between 151 small molecules and 747 miRNAs in 17 species after manual curation from nearly 2000 articles. Each entry contains the detailed information about small molecules, miRNAs and evidences of their relationships, such as species, miRBase Accession number, DrugBank Accession number, PubChem Compound Identifier (CID), expression pattern of miRNA, experimental method, tissues or conditions for detection. SM2miR database has a user-friendly interface to retrieve by miRNA or small molecule. In addition, we offered a submission page. Thus, SM2miR provides a fairly comprehensive repository about the influences of small molecules on miRNA expression, which will promote the development of miRNA therapeutics.
  
  
  BACKGROUND
  SM2miR is freely available at http://bioinfo.hrbmu.edu.cn/SM2miR/.
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Liu
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Wang
authors.forename: Fanlin
authors.initials: F
authors.lastname: Meng
authors.forename: Jizhe
authors.initials: J
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Enyu
authors.initials: E
authors.lastname: Dai
authors.forename: Xuexin
authors.initials: X
authors.lastname: Yu
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
mesh_terms: D030561:Databases, Nucleic Acid; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D020407:Internet; D035683:MicroRNAs / Q000378:metabolism*; D014584:User-Computer Interface
chemical_list: D035683:MicroRNAs