title: [Cancer stem cells, cornerstone of radioresistance and perspectives for radiosensitization: glioblastoma as an example].
abstract: Cancer stem cells are a subject of increasing interest in oncology. In particular, several data suggest that cancer stem cells are involved in the mechanisms of tumor radioresistance, and may explain the therapeutic failures after radiotherapy. Because of its poor prognosis and high recurrence rate after irradiation, glioblastoma model is often studied in the search for new radiosensitizers. There are several preclinical data suggesting that cancer stem cells could be a potential therapeutic target for improving the biological effectiveness of radiation therapy. Through the example of glioblastoma, we review the main signaling pathways involved in the mechanisms of radiation resistance of cancer stem cells and for which pharmacological targeting could potentially enhance tumor radiosensitivity.
authors.affiliation: Hôpital d'instruction des armées du Val-de-Grâce, service d'oncologie-radiothérapie, 74, boulevard de Port-Royal, 75230 Paris cedex, France.
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chargari
authors.forename: Coralie
authors.initials: C
authors.lastname: Moncharmont
authors.forename: Antonin
authors.initials: A
authors.lastname: Lévy
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Guy
authors.forename: Gérald
authors.initials: G
authors.lastname: Bertrand
authors.forename: Matthieu
authors.initials: M
authors.lastname: Guilbert
authors.forename: Claire
authors.initials: C
authors.lastname: Rousseau
authors.forename: Lionel
authors.initials: L
authors.lastname: Védrine
authors.forename: Gersende
authors.initials: G
authors.lastname: Alphonse
authors.forename: Robert-Alain
authors.initials: RA
authors.lastname: Toillon
authors.forename: Claire
authors.initials: C
authors.lastname: Rodriguez-Lafrasse
authors.forename: Eric
authors.initials: E
authors.lastname: Deutsch
authors.forename: Nicolas
authors.initials: N
authors.lastname: Magné
mesh_terms: D000071916:AC133 Antigen; D015703:Antigens, CD / Q000378:metabolism; D002453:Cell Cycle; D004260:DNA Repair / Q000502:physiology; D005909:Glioblastoma / Q000378:metabolism / Q000532:radiotherapy*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects*; D010455:Peptides / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011836:Radiation Tolerance / Q000187:drug effects* / Q000502:physiology; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D015398:Signal Transduction / Q000502:physiology*; D055153:Stem Cell Niche / Q000502:physiology; D059016:Tumor Microenvironment / Q000502:physiology
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; D009363:Neoplasm Proteins; D010455:Peptides; D011838:Radiation-Sensitizing Agents; D011505:Protein-Tyrosine Kinases