title: A marginal level of dystrophin partially ameliorates hindlimb muscle passive mechanical properties in dystrophin-null mice.
abstract: BACKGROUND
  The goal of this study was to determine whether a minimal level of dystrophin expression improves the passive mechanical properties of skeletal muscle in the murine Duchenne muscular dystrophy model.
  
  
  METHODS
  We compared the elastic and viscous properties of the extensor digitorum longus muscle (EDL) in mdx3cv and mdx4cv mice at 6, 14, and 20 months of age. Both strains are on the C57Bl/6 background, and both lose the full-length dystrophin protein. Interestingly, mdx3cv mice express a near full-length dystrophin at ≈ 5% of the normal level.
  
  
  RESULTS
  We found that the stress-strain profile and the stress relaxation rate of the EDL in mdx3cv mice were partially preserved in all age groups compared with age-matched mdx4cv mice.
  
  
  CONCLUSIONS
  Our results suggest that a low level of dystrophin expression may treat muscle stiffness in Duchenne muscular dystrophy.
authors.affiliation: Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, One Hospital Drive, Columbia, Missouri 65212, USA.
authors.forename: Chady H
authors.initials: CH
authors.lastname: Hakim
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Duan
mesh_terms: D000367:Age Factors; D000818:Animals; D004195:Disease Models, Animal; D016189:Dystrophin / Q000096:biosynthesis / Q000172:deficiency*; D005786:Gene Expression Regulation; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009119:Muscle Contraction / Q000502:physiology*; D009136:Muscular Dystrophies / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D009137:Muscular Dystrophy, Animal; D009154:Mutation; D013314:Stress, Mechanical
chemical_list: D016189:Dystrophin; D006909:Hydroxyproline