title: Hypotensive syndromes are not associated with cognitive impairment in geriatric patients.
abstract: To investigate the association of the hypotensive syndromes orthostatic hypotension (OH), postprandial hypotension (PPH), and carotid sinus hypersensitivity (CSH) with cognitive impairment (mild cognitive impairment/dementia). Continuous measurements of blood pressure (Finapres) were performed during active standing, meal test, and carotid sinus massage, among 184 elderly patients presenting with falls. Mild cognitive impairment (MCI) and dementia were diagnosed following a multidisciplinary assessment. The study design was a retrospective cohort study. The OH, PPH, and CSH were observed in 104 (58%), 108 (64%), and 78 (51%) patients, respectively. A total of 79 (43%) patients were cognitively impaired (MCI impairment n = 44; dementia n = 35). The prevalence of cognitive impairment varied little across the hypotensive syndromes (32%-43%) and was similar in patients with and without hypotensive syndromes (P = .59). In this geriatric population with a high prevalence of both hypotensive syndromes and cognitive impairment, patients with one or more hypotensive syndromes were not likely to have cognitive impairment.
authors.affiliation: Department of Geriatric Medicine, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands. y.schoon@ger.umcn.nl
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Schoon
authors.forename: Joep
authors.initials: J
authors.lastname: Lagro
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Verhoeven
authors.forename: Marcel Olde
authors.initials: MO
authors.lastname: Rikkert
authors.forename: Jurgen
authors.initials: J
authors.lastname: Claassen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001795:Blood Pressure Determination / Q000379:methods; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000453:epidemiology; D015897:Comorbidity; D003704:Dementia / Q000175:diagnosis* / Q000453:epidemiology; D015577:Geriatric Assessment; D006801:Humans; D007022:Hypotension / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology; D007024:Hypotension, Orthostatic / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D009483:Neuropsychological Tests; D013577:Syndrome