title: Doxorubicin treatment inhibits PPARγ and may induce lipotoxicity by mimicking a type 2 diabetes-like condition in rodent models.
abstract: Doxorubicin-treated animals show elevated serum triglyceride and blood glucose levels. Adipocytes play an important role in buffering blood glucose and lipids. A raise in serum lipid level triggers adipogenesis in order to increase the lipid absorption capacity of adipose tissue. Doxorubicin inhibits adipogenesis through the down-regulation of PPARγ, a crucial component of the lipid metabolic pathway which controls the expression of glucose and fatty acid transporters. Doxorubicin-mediated down-regulation of PPARγ inhibits blood glucose and lipid clearance thereby causing hyperglycemia and hyperlipidemia resulting in lipotoxicity, glucotoxicity, inflammation and insulin resistance. Therefore we hypothesize that doxorubicin treatment could mimic a type 2 diabetic condition.
authors.affiliation: Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.
authors.forename: Sankarganesh
authors.initials: S
authors.lastname: Arunachalam
authors.forename: P B
authors.initials: PB
authors.lastname: Tirupathi Pichiah
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Achiraman
mesh_terms: D050156:Adipogenesis / Q000187:drug effects; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000633:toxicity*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D051379:Mice; D008954:Models, Biological; D047495:PPAR gamma / Q000037:antagonists & inhibitors*
chemical_list: D001786:Blood Glucose; D008055:Lipids; D047495:PPAR gamma; D004317:Doxorubicin