title: [Effects of total saponin from Panax japonicus on acute myocardial ischemia injury induced by ligating coronary artery left anterior descending branch in rats].
abstract: OBJECTIVE
  To investigate the cardioprotective effects of total saponin from Panax japonicus pretreating on acute myocardial ischemia injury induced by ligating coronary artery left anterior descending branch (LAD) in rats.
  
  
  METHODS
  Rats were divided into sham group, model group and total saponin group. The treatment group was given total saponin of Panax japonicus. After pretreating for 7 days, the rats' acute myocardial ischemia model was induced by LAD. The electrocardiogram, hemodynamics, infarct size and histomorphology were assessed 12 h after LAD, the serum levels of phosphokinase (CK), lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) were also measured.
  
  
  RESULTS
  Compared with the model group, total saponin from Panax japonicus significantly improved heart function, heart histomorphology, opposed ECG T wave decreased and decreased infarct size; Remarkably decreased the contents of LDH, CK and MDA, increased the activity of SOD, CAT.
  
  
  CONCLUSIONS
  Total saponin from Panax japonicus has cardioprotective effects on acute myocardial ischemic injury and the mechanism may be related to antioxidation.
authors.affiliation: College of Medical Sciences, Three Gorges University, Yichang 443002, China. shmq0212@126.com
authors.forename: Hai-bo
authors.initials: HB
authors.lastname: He
authors.forename: Jia
authors.initials: J
authors.lastname: Xu
authors.forename: Yuan-qing
authors.initials: YQ
authors.lastname: Xu
authors.forename: Hong-wu
authors.initials: HW
authors.lastname: Wang
authors.forename: Guo-jie
authors.initials: GJ
authors.lastname: Di
authors.forename: Shou-chao
authors.initials: SC
authors.lastname: Li
authors.forename: Zhi-wei
authors.initials: ZW
authors.lastname: Sun
authors.forename: Yu-min
authors.initials: YM
authors.lastname: He
authors.forename: Ding
authors.initials: D
authors.lastname: Yuan
mesh_terms: D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002374:Catalase / Q000097:blood; D004195:Disease Models, Animal; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009203:Myocardial Infarction / Q000517:prevention & control; D017202:Myocardial Ischemia / Q000097:blood / Q000188:drug therapy*; D009206:Myocardium / Q000473:pathology; D018384:Oxidative Stress; D005894:Panax / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D002316:Cardiotonic Agents; D012503:Saponins; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D002374:Catalase; D013482:Superoxide Dismutase