title: Immunosignaturing: a critical review.
abstract: Health is a complex interaction between metabolism, physiology, and immunity. Although it is difficult to define quantitatively, the activity of the humoral immune system provides a reasonable proxy for changes in health. Immunosignaturing is a microarray-based technology that quantitates the dynamics of circulating antibodies. Recent advancements in the field warrant a review of the technology. Here, we provide an introduction to the technique, evaluate the current progress, contrast similar technologies, and suggest applications that immunosignaturing could facilitate.
authors.affiliation: HealthTell Inc., 145 South 79th Street, Chandler, AZ 85226, USA.
authors.forename: Kathryn F
authors.initials: KF
authors.lastname: Sykes
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Legutki
authors.forename: Phillip
authors.initials: P
authors.lastname: Stafford
mesh_terms: D000906:Antibodies / Q000097:blood / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D020811:Biomedical Technology / Q000379:methods*; D003429:Cross Reactions; D042241:Early Diagnosis; D006801:Humans; D046228:Microarray Analysis / Q000379:methods*
chemical_list: D000906:Antibodies; D015415:Biomarkers