title: Effects of ceftriaxone on ischemia/reperfusion injury in rat brain.
abstract: The aim of this study was to investigate the effect of ceftriaxone treatment against short-term global brain ischemia/reperfusion (I/R) injury in rats. The study was carried out on 30 Wistar-albino rats that were divided into three groups: control group (n=10), I/R group (n=10) and I/R-ceftriaxone group (n=10). Malondialdehyde (MDA) levels were significantly increased in the I/R group in comparison with the control group (p<0.001). MDA was significantly lower in the I/R-ceftriaxone group than in the I/R group (p<0.05). Superoxide dismutase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the control group. Glutathione peroxidase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the I/R group and the control. Histopathologically, ceftriaxone provided morphological improvement compared with the I/R group. We concluded that ceftriaxone has neuron-protective effects due to its antioxidant properties as shown by a decrease in MDA overproduction and histological improvement in brain tissue.
authors.affiliation: Department of Neurosurgery, Tayfur Ata Sökmen Medical Faculty, Mustafa Kemal University, Hatay 31700, Turkey. draltasmurat@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Altaş
authors.forename: S
authors.initials: S
authors.lastname: Meydan
authors.forename: M
authors.initials: M
authors.lastname: Aras
authors.forename: N
authors.initials: N
authors.lastname: Yılmaz
authors.forename: K T
authors.initials: KT
authors.lastname: Ulutaş
authors.forename: H M
authors.initials: HM
authors.lastname: Okuyan
authors.forename: A
authors.initials: A
authors.lastname: Nacar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002545:Brain Ischemia / Q000188:drug therapy*; D002443:Ceftriaxone / Q000494:pharmacology*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy*
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D002443:Ceftriaxone