title: Long-range anion relay chemistry (LR-ARC): a validated ARC tactic.
abstract: The design, synthesis, and validation of linchpins for Anion Relay Chemistry (ARC) capable of iterative silyl group migrations have been achieved. This tactic permits "long-range" relocation of negative charge across space, to generate reactive distal nucleophilic centers for both alkylation and palladium-catalyzed coupling reactions.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Luis
authors.initials: L
authors.lastname: Sanchez
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
mesh_terms: D000478:Alkylation; D000838:Anions / Q000737:chemistry; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*
chemical_list: D000838:Anions; D001555:Benzene Derivatives; D012821:Silanes; D010165:Palladium