title: SOCS proteins in infectious diseases of mammals.
abstract: As for most biological processes, the immune response to microbial infections has to be tightly controlled to remain beneficial for the host. Inflammation is one of the major consequences of the host's immune response. For its orchestration, this process requires a fine-tuned interplay between interleukins, endothelial cells and various types of recruited immune cells. Suppressors of cytokine signalling (SOCS) proteins are crucially involved in the complex control of the inflammatory response through their actions on various signalling pathways including the JAK/STAT and NF-κB pathways. Due to their cytokine regulatory functions, they are frequent targets for exploitation by infectious agents trying to escape the host's immune response. This review article aims to summarize our current knowledge regarding SOCS family members in the different mammalian species studied so far, and to display their complex molecular interactions with microbial pathogens.
authors.affiliation: Institut National de la Recherche Agronomique (INRA), UMR1282 Infectiologie et Santé Publique, F-37380 Nouzilly, France.
authors.forename: Mario
authors.initials: M
authors.lastname: Delgado-Ortega
authors.forename: Daniel
authors.initials: D
authors.lastname: Marc
authors.forename: Joëlle
authors.initials: J
authors.lastname: Dupont
authors.forename: Sascha
authors.initials: S
authors.lastname: Trapp
authors.forename: Mustapha
authors.initials: M
authors.lastname: Berri
authors.forename: François
authors.initials: F
authors.lastname: Meurens
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000662:veterinary; D006801:Humans; D007155:Immunologic Factors / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007239:Infections / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000662:veterinary*; D008322:Mammals; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010273:Parasitic Diseases, Animal / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000662:veterinary
chemical_list: D007155:Immunologic Factors; D050826:Suppressor of Cytokine Signaling Proteins