title: Highly regioselective opening of zirconacyclopentadienes by remote coordination: concise synthesis of the furan core of the leupyrrins.
abstract: An efficient protocol for the highly regioselective opening of aliphatic zirconacyclopentadienes is reported. The one-pot process involves a zirconocene-mediated cyclization of 1,6-diynes and highly selective cleavage of the metallacycles with NBS and enables a concise synthesis of the tetrahydrofuran-core of the leupyrrins.
authors.affiliation: University of Heidelberg, Department of Organic Chemistry, INF 270, D-69120 Heidelberg, Germany, EU.
authors.forename: Thomas
authors.initials: T
authors.lastname: Debnar
authors.forename: Sandra
authors.initials: S
authors.lastname: Dreisigacker
authors.forename: Dirk
authors.initials: D
authors.lastname: Menche