title: A new atherogenic effect of saturated fatty acids.
abstract: There is increasing evidence that dietary saturated fatty acids (SAFA) have not only an indirect atherogenic effect due to increasing LDL-cholesterol concentration but also a direct effect by activating the inflammation process. This review summarizes several recent publications in this field. The effect of SAFA on the inflammation process mediated by Toll-like receptor 4/NF-kappaB pathway has been well documented in various in vitro culture studies of macrophages and adipocytes or in their co-culture. In contrast to these in vitro data, in vivo epidemiological studies or clinical experiments in men are less consistent. Well controlled cross-over studies in volunteers might enlighten the differences between saturated and unsaturated fatty acids dietary intake and proatherogenic inflammation effects.
authors.affiliation: Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. rudolf.poledne@ikem.cz
authors.forename: R
authors.initials: R
authors.lastname: Poledne
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000139:chemically induced* / Q000473:pathology; D004041:Dietary Fats / Q000009:adverse effects*; D005227:Fatty Acids / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced* / Q000473:pathology; D016328:NF-kappa B / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects; D051197:Toll-Like Receptor 4 / Q000187:drug effects / Q000502:physiology
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D016328:NF-kappa B; D051197:Toll-Like Receptor 4