title: Pulse wave velocity, blood pressure and adipocytokines in young adults: the Rio de Janeiro study.
abstract: BACKGROUND
  Data on noninvasive vascular assessment and their association with cardiovascular risk variables are scarce in young individuals.
  
  
  OBJECTIVE
  To evaluate the association between pulse wave velocity and blood pressure, anthropometric and metabolic variables, including adipocytokines, in young adults.
  
  
  METHODS
  A total of 96 individuals aged 26 to 35 years (mean 30.09 ± 1.92; 51 males) were assessed in the Rio de Janeiro study. Pulse wave velocity (Complior method), blood pressure, body mass index, glucose, lipid profile, leptin, insulin, adiponectin and insulin resistance index (HOMA-IR) were analyzed. Subjects were stratified into three groups according to the PWV tertile for each gender.
  
  
  RESULTS
  The group with the highest pulse wave velocity (PWV) tertile showed higher mean systolic and diastolic blood pressure, mean blood pressure, body mass index, insulin, and HOMA-IR, as well as lower mean adiponectin; higher prevalence of diabetes mellitus/glucose intolerance and hyperinsulinemia. There was a significant positive correlation of PWV with systolic blood pressure, diastolic blood pressure, pulse pressure and mean blood pressure, body mass index, and LDL-cholesterol, and a negative correlation with HDL-cholesterol and adiponectin. In the multiple regression model, after adjustment of HDL-cholesterol, LDL-cholesterol and adiponectin for gender, age, body mass index and mean blood pressure, only the male gender and mean blood pressure remained significantly correlated with PWV.
  
  
  CONCLUSIONS
  PWV in young adults showed a significant association with cardiovascular risk variables, especially in the male gender, and mean blood pressure as important determinant variables. The findings suggest that PWV measurement can be useful for the identification of vascular impairment in this age group.
authors.affiliation: Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. olpizzi@cardiol.br
authors.forename: Oswaldo Luiz
authors.initials: OL
authors.lastname: Pizzi
authors.forename: Andréa Araujo
authors.initials: AA
authors.lastname: Brandão
authors.forename: Roberto
authors.initials: R
authors.lastname: Pozzan
authors.forename: Maria Eliane Campos
authors.initials: ME
authors.lastname: Magalhães
authors.forename: Erika Maria Gonçalves
authors.initials: EM
authors.lastname: Campana
authors.forename: Flavia Lopes
authors.initials: FL
authors.lastname: Fonseca
authors.forename: Elizabete Viana de
authors.initials: EV
authors.lastname: Freitas
authors.forename: Ayrton Pires
authors.initials: AP
authors.lastname: Brandão
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000886:Anthropometry; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination; D001938:Brazil; D002318:Cardiovascular Diseases / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D063177:Pulse Wave Analysis; D012307:Risk Factors; D017678:Sex Distribution
chemical_list: D054392:Adipokines