title: Toward personalized cell therapies by using stem cells: seven relevant topics for safety and success in stem cell therapy.
abstract: Stem cells, both embryonic and adult, due to the potential for application in tissue regeneration have been the target of interest to the world scientific community. In fact, stem cells can be considered revolutionary in the field of medicine, especially in the treatment of a wide range of human diseases. However, caution is needed in the clinical application of such cells and this is an issue that demands more studies. This paper will discuss some controversial issues of importance for achieving cell therapy safety and success. Particularly, the following aspects of stem cell biology will be presented: methods for stem cells culture, teratogenic or tumorigenic potential, cellular dose, proliferation, senescence, karyotyping, and immunosuppressive activity.
authors.affiliation: Post-Graduation Program in Biotechnology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: de Sá Silva
authors.forename: Paula Nascimento
authors.initials: PN
authors.lastname: Almeida
authors.forename: João Vitor Paes
authors.initials: JV
authors.lastname: Rettore
authors.forename: Claudinéia Pereira
authors.initials: CP
authors.lastname: Maranduba
authors.forename: Camila Maurmann
authors.initials: CM
authors.lastname: de Souza
authors.forename: Gustavo Torres
authors.initials: GT
authors.lastname: de Souza
authors.forename: Rafaella de Souza Salomão
authors.initials: Rde S
authors.lastname: Zanette
authors.forename: Sueli Patricia Harumi
authors.initials: SP
authors.lastname: Miyagi
authors.forename: Marcelo de Oliveira
authors.initials: Mde O
authors.lastname: Santos
authors.forename: Márcia Martins
authors.initials: MM
authors.lastname: Marques
authors.forename: Carlos Magno da Costa
authors.initials: CM
authors.lastname: Maranduba
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006801:Humans; D057285:Precision Medicine / Q000379:methods*; D033581:Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods*; D013234:Stem Cells / Q000166:cytology* / Q000276:immunology; D016896:Treatment Outcome