title: The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer.
abstract: The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.
authors.affiliation: Department of Dermatology and Pathology, Duke University Durham, NC, USA.
authors.forename: Jennifer Y
authors.initials: JY
authors.lastname: Zhang
authors.forename: Maria Angelica
authors.initials: MA
authors.lastname: Selim