title: Genomic analysis of human rotavirus strains G6P[14] and G11P[25] isolated from Kolkata in 2009 reveals interspecies transmission and complex reassortment events.
abstract: In a community based case-control study in Kolkata, India, in 2009, two human rotaviruses with uncommon genotypes G6P[14] and G11P[25] were identified, having bovine and porcine characteristics respectively. Strain N-1/2009 with G6P[14] and strain N-38/2009 with G11P[25] genotypes, were isolated from a 13months aged boy who was asymptomatic and a 10months old girl with severe diarrhea respectively. The remaining 9 gene segments of these two strains were analyzed to find the exact origin of these unusual rotaviruses, and the origin of these two strains from bovine/porcine rotaviruses was apparent. This study identifies zoonotic transmission and single and multiple reassortment events as mechanisms driving the diversity of human rotaviruses. This study indicates interspecies transmission between human and animal rotaviruses causes single or multiple reassortment and thus contribute to the genetic diversity of rotavirus.
authors.affiliation: National Institute of Cholera and Enteric Diseases, Kolkata, India.
authors.forename: Satarupa
authors.initials: S
authors.lastname: Mullick
authors.forename: Anupam
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Santanu
authors.initials: S
authors.lastname: Ghosh
authors.forename: Gururaja P
authors.initials: GP
authors.lastname: Pazhani
authors.forename: Dipika
authors.initials: D
authors.lastname: Sur
authors.forename: Byomkesh
authors.initials: B
authors.lastname: Manna
authors.forename: James P
authors.initials: JP
authors.lastname: Nataro
authors.forename: Myron M
authors.initials: MM
authors.lastname: Levine
authors.forename: Thandavarayan
authors.initials: T
authors.lastname: Ramamurthy
authors.forename: Mamta
authors.initials: M
authors.lastname: Chawla-Sarkar
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000235:genetics; D016022:Case-Control Studies; D016679:Genome, Viral; D006801:Humans; D007194:India; D008969:Molecular Sequence Data; D010802:Phylogeny; D016865:Reassortant Viruses / Q000235:genetics*; D012401:Rotavirus / Q000145:classification* / Q000235:genetics*; D012400:Rotavirus Infections / Q000635:transmission* / Q000821:virology*
chemical_list: D036022:Capsid Proteins