title: High-throughput approaches to discover novel immunomodulatory agents for cancer.
abstract: The clinical success of immunomodulatory thalidomide derivatives has renewed the general interest in immunomodulatory anticancer compounds and prompted us to develop a high-throughput system to quantify immune effector-cell activity. We documented that the interaction between cancer cells, their stroma, anticancer agents and cells from the innate system are critical for determining the response of tumors to immunomodulatory strategies.
authors.affiliation: Department of Medical Oncology; Dana-Farber Cancer Institute; Boston, MA USA ; Department of Medicine; Harvard Medical School; Boston, MA USA.
authors.forename: Douglas W
authors.initials: DW
authors.lastname: McMillin
authors.forename: Constantine S
authors.initials: CS
authors.lastname: Mitsiades