title: [Cohort study of ischemic heart disease among 1817 workers in a foundry].
abstract: OBJECTIVE
  To determine the risk of ischemic heart disease among foundry workers and the exposure-response relationship between the risk and foundry work and cumulative exposure to silica dust, and to establish a regression model to predict the risk for developing ischemic heart disease by a given length of employment and exposure to silica dust in foundry workers.
  
  
  METHODS
  Cohort study was conducted, following-up workers in an automobile foundry employed for more than one year during January 1, 1980 to December 31, 1996 as cohort members. In total, 30 years were followed to December 31, 2009. In cohort, workers exposed to pouring, sand preparation, cast shakeout and finishing, melting, overhead crane operation, moulding and core-making were in foundry group, and auxiliary workers at the same factory, such as electricians, fitters, and inspectors were in control group. The risk of ischemic heart disease among foundry workers and the exposure-response relationship between the risk and foundry work and cumulative exposure to silica dust were analyzed with cox regression model using SPSS software, and a logistic regression model was established for prediction of risk for developing ischemic heart disease at a given length of employment and exposure to silica dust in foundry workers.
  
  
  RESULTS
  Totally, 1817 workers were followed-up for 45 553.05 person-years during 30 years, with 156 cases of ischemic heart disease and incidence of 342.46 per 100 000 person-years. And the average age at onset was 51.46 years and duration of employment at onset was 21.61 years. Results showed that male, smoking, alcohol drinking, age and duration of employment were risk factors for ischemic heart disease. Risk of ischemic heart disease in foundry workers positively correlated with cumulative silica exposure, and the risk of ischemic heart disease increased by 75.8 percent (RR = 1.758, 95% CI 1.221-2.532) with cumulative silica exposure of 1 mg/m3 x year, adjusted for smoking. And risk of ischemic heart disease was significantly higher in the exposed group than that in the control one. Compared with control group workers, risk of ischemic heart disease increased by 1.048 folds, 1.395 folds, 70.4 percent, 97.0 percent and 1.270 folds among workers exposed to sand preparation, cast shakeout and finishing, melting, moulding and core-making, respectively, adjusted for smoking. Based on the predictive of model, risk for developing ischemic heart disease increased with the length of employment and exposure to silica dust in foundry workers.
  
  
  CONCLUSIONS
  Workers in foundry face high risk of ischemic heart disease. Risk of ischemic heart disease varies by job, which is higher in workers exposed to sand preparation, cast shakeout and finishing, melting, moulding and core-making. Both foundry work and cumulative exposure to silica are risk factors. The model for prediction of risk for developing ischemic heart disease at a given length of employment and exposure to silica dust in foundry workers resulted in a valid exposure-response relationship.
authors.affiliation: National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China. ly0187@yahoo.cn
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D004391:Dust / Q000032:analysis; D005260:Female; D006801:Humans; D015994:Incidence; D007221:Industry; D008297:Male; D008875:Middle Aged; D018986:Motor Vehicles; D017202:Myocardial Ischemia / Q000453:epidemiology*; D009784:Occupational Diseases / Q000453:epidemiology; D016273:Occupational Exposure / Q000009:adverse effects*; D012822:Silicon Dioxide / Q000032:analysis*
chemical_list: D004391:Dust; D012822:Silicon Dioxide