title: [Assessment of endogenous thrombin potential and influence on it of different regimens of heparin therapy in patients with abdominal sepsis].
abstract: Abdominal sepsis (AS) is a systemic inflammatory reaction of organism in response to the development of infectious process in organs of the abdominal cavity. The course of AS is complicated by hypercoagulation syndrome which facilitates progression of endogenous intoxication. The investigation included 26 patients (14 men and 12 women, mean age 65.5 +/- 16.4 years) with AS. The test of thrombin generation (TTG) used in patients with AS allows assessment of changes in the hemostasis system and control of the heparin dose. It was established that TTG revealed elevated endogenous thrombin potential of blood practically in all patients with AS. In the patients given 25 000 IU of heparin the TTG indices showed a reliably decreased endogenous thrombin potential and peak thrombin concentration as compared with a group of patients given 10 000 IU of heparin.
authors.forename: Kh A
authors.initials: KhA
authors.lastname: Gamzatov
authors.forename: D V
authors.initials: DV
authors.lastname: Gurzhiĭ
authors.forename: S M
authors.initials: SM
authors.lastname: Lazarev
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Nemestnikov
authors.forename: A A
authors.initials: AA
authors.lastname: Gurzhiĭ
authors.forename: L P
authors.initials: LP
authors.lastname: Panaian
authors.forename: O G
authors.initials: OG
authors.lastname: Golovina
authors.forename: E A
authors.initials: EA
authors.lastname: Khait
authors.forename: O A
authors.initials: OA
authors.lastname: Smirnova
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Matvienko
mesh_terms: D000005:Abdomen; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D018805:Sepsis / Q000097:blood / Q000188:drug therapy*; D013917:Thrombin / Q000187:drug effects / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006493:Heparin; D013917:Thrombin