title: Daintain/AIF-1 reinforces the resistance of breast cancer cells to cisplatin.
abstract: Our previous studies revealed that daintain/AIF-1 promoted the proliferation and migration of breast cancer cells. In the present study, we investigated the effect of daintain/AIF-1 on the cisplatin resistance of breast cancer cells. The results indicated that daintain/AIF-1 reinforced the resistance of breast cancer cells to cisplatin by inhibition of cell apoptosis and reduction of intracellular cisplatin accumulation.
authors.affiliation: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Sciences and Technology, Huazhong University of Science and Technology, Hubei, China.
authors.forename: Shaohui
authors.initials: S
authors.lastname: Jia
authors.forename: Moctar Ali
authors.initials: MA
authors.lastname: Chaibou
authors.forename: Zhengwang
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D002135:Calcium-Binding Proteins; D002945:Cisplatin / Q000494:pharmacology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D061986:MCF-7 Cells; D008840:Microfilament Proteins
chemical_list: C112986:AIF1 protein, human; D000970:Antineoplastic Agents; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D008840:Microfilament Proteins; D002945:Cisplatin