title: Morphological and clinical risk factors for the rupture of anterior communicating artery aneurysms.
abstract: OBJECTIVE
  Patients with ruptured anterior communicating artery (ACoA) aneurysms have historically been observed to have poor neuropsychological outcomes, and ACoA aneurysms have accounted for a higher proportion of ruptured than unruptured aneurysms. Authors of this study aimed to investigate the morphological and clinical characteristics predisposing to ACoA aneurysm rupture.
  
  
  METHODS
  Data from 140 consecutive patients with ACoA aneurysms managed at the authors' facility between July 2003 and November 2011 were retrospectively reviewed. Patients with (78) and without (62) aneurysm rupture were divided into groups, and morphological and clinical characteristics were compared. Morphological characteristics were evaluated based on 3D CT angiography and included aneurysm location, dominance of the A1 portion of the anterior cerebral artery, direction of the aneurysm dome around the ACoA, aneurysm bleb(s), size of the aneurysm and its neck, aneurysm-parent artery angle, and existence of other intracranial unruptured aneurysms.
  
  
  RESULTS
  Patients with ruptured ACoA aneurysms were significantly younger (a higher proportion were younger than 60 years of age) than those with unruptured lesions, and a significantly smaller proportion had hypercholesterolemia. A significantly larger proportion of patients with ruptured aneurysms showed an anterior direction of the aneurysm dome around the ACoA, had a bleb(s), and/or had an aneurysm size ≥ 5 mm. Multivariate logistic regression analysis showed that an anterior direction of the aneurysm dome around the ACoA (OR 6.0, p = 0.0012), the presence of a bleb(s) (OR 22, p < 0.0001), and an aneurysm size ≥ 5 mm (OR 3.16, p = 0.035) were significantly associated with ACoA aneurysm rupture.
  
  
  CONCLUSIONS
  Findings in the present study demonstrated that the anterior projection of an ACoA aneurysm may be related to rupturing. The authors would perhaps recommend treatment to patients with unruptured ACoA aneurysms that have an anterior dome projection, a bleb(s), and a size ≥ 5 mm.
authors.affiliation: Department of Neurosurgery, St. Luke’s International Hospital, Chuo-ku, Tokyo, Japan. mahide@luke.or.jp
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Matsukawa
authors.forename: Akihiro
authors.initials: A
authors.lastname: Uemura
authors.forename: Motoharu
authors.initials: M
authors.lastname: Fujii
authors.forename: Minobu
authors.initials: M
authors.lastname: Kamo
authors.forename: Osamu
authors.initials: O
authors.lastname: Takahashi
authors.forename: Sosuke
authors.initials: S
authors.lastname: Sumiyoshi
mesh_terms: D000368:Aged; D017542:Aneurysm, Ruptured / Q000453:epidemiology*; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors