title: Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and  meta-analysis.
abstract: We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529 T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). However, rs3900115 and rs13010627 showed no association with cancer susceptibility (all P > 0.05). In the subgroup analysis by cancer type, we found that the rs13006529 T carrier was a risk factor for breast cancer (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). Similarly, no association was found between CASP-10 polymorphisms and susceptibility to lymphoma, myeloma, melanoma, or lung cancer (all P > 0.05). This meta-analysis suggests that the rs13006529 T carrier in the CASP-10 gene might be a risk factor for cancer susceptibility, especially for breast cancer.
authors.affiliation: Department of Urological Surgery, Fourth Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: S
authors.initials: S
authors.lastname: Yan
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Li
authors.forename: J W
authors.initials: JW
authors.lastname: Zhu
authors.forename: C L
authors.initials: CL
authors.lastname: Liu
authors.forename: P
authors.initials: P
authors.lastname: Wang
authors.forename: Y L
authors.initials: YL
authors.lastname: Liu
mesh_terms: D016022:Case-Control Studies; D053455:Caspase 10 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D016014:Linear Models; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
chemical_list: D053455:Caspase 10; C506438:CASP10 protein, human