title: Pneumococcal serotype distribution among meningitis cases from Togo and Burkina Faso during 2007-2009.
abstract: We evaluated pneumococcal serotype/group distribution using polymerase chain reaction (PCR) testing on cerebrospinal fluid collected from patients from Burkina Faso and Togo who presented for care during 2007-2009. We identified 282 pneumococcal meningitis cases based on PCR, latex agglutination, or culture, of which 206 underwent serotyping. Serotype 1 was identified for 18% of serotyped cases from patients aged <5 years and 66% of those aged ≥5 years. The 13-valent and 10-valent pneumococcal conjugate vaccines (PCV-13 and PCV-10) contain 53% of serotypes identified among children age <5 years and 76-77% among persons aged ≥5 years. Pneumococcal meningitis was highly seasonal regardless of serotype. Data from this study emphasize the potential usefulness of PCVs among older children and adults.
authors.affiliation: Agence de Medecine Preventive, Paris, France. bgessner@aamp.org
authors.forename: Bradford D
authors.initials: BD
authors.lastname: Gessner
authors.forename: Oumarou
authors.initials: O
authors.lastname: Sanou
authors.forename: Aly
authors.initials: A
authors.lastname: Drabo
authors.forename: Tsidi Agbeko
authors.initials: TA
authors.lastname: Tamekloe
authors.forename: Seydou
authors.initials: S
authors.lastname: Yaro
authors.forename: Haoua
authors.initials: H
authors.lastname: Tall
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Moïsi
authors.forename: Judith E
authors.initials: JE
authors.lastname: Mueller
authors.forename: Berthe-Marie
authors.initials: BM
authors.lastname: Njanpop-LaFourcade
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002050:Burkina Faso / Q000453:epidemiology; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008586:Meningitis, Pneumococcal / Q000453:epidemiology* / Q000382:microbiology*; D008875:Middle Aged; D022242:Pneumococcal Vaccines / Q000276:immunology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012621:Seasons; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D014037:Togo / Q000453:epidemiology; D018074:Vaccines, Conjugate / Q000276:immunology; D055815:Young Adult
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate