title: Effects of gender and aging in patients who undergo coronary artery bypass grafting: from the FU-Registry.
abstract: BACKGROUND
  It is unclear whether gender and aging influence the characteristics of patients who undergo coronary artery bypass grafting (CABG).
  
  
  METHODS
  We retrospectively reviewed a clinical database of 1,498 patients (male/female = 1133/365, age 67 ± 9 years) who underwent CABG at Fukuoka University Hospital from 1994 to 2010.
  
  
  RESULTS
  Male showed significantly younger, higher percentages (%) of smoking and hyperuricemia (HU), higher levels of serum creatinine, and lower % hypertension (HT) and diabetes mellitus (DM), and lower levels of left ventricular ejection fraction than female. In multivariate analysis, all parameters identified independent variables associated with the gender difference. Next, we divided the patients into 5 groups according to age, and each group was then separated by gender. The % of males significantly decreased with aging, whereas % female significantly increased. Although % smoking and estimated glomerular filtration rate (eGFR), and body mass index (BMI) in all patients, males and females significantly decreased with aging, HU, left ventricular end diastolic pressure and the number of significantly stenosed coronary vessels were not associated with gender or aging. Interestingly, % HT in all patients and males significantly increased with aging, whereas that in females was not associated with aging. Serum low-density lipoprotein cholesterol levels in males significantly decreased with aging, while those in all patients and females were not associated with aging. In this contemporary data set, the decreases in % smoking and eGFR with aging were common characteristics in male and female patients. In addition, there were gender and aging differences in % smoking, % HT, BMI and eGFR, whereas no differences were observed in % DM, % dyslipidemia or % HU.
  
  
  CONCLUSIONS
  Before CABG, high-risk patients with coronary artery disease who is going to undergo CABG may need to be managed more strictly considering to gender and age to avoid CABG.
authors.affiliation: Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Shimizu
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Miura
authors.forename: Kazuma
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Tashiro
authors.forename: Keijiro
authors.initials: K
authors.lastname: Saku
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000465:Algorithms; D015992:Body Mass Index; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D048909:Diabetes Complications / Q000453:epidemiology; D005260:Female; D006785:Hospitals, University; D006801:Humans; D006973:Hypertension / Q000150:complications; D033461:Hyperuricemia / Q000150:complications; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects; D013318:Stroke Volume; D016896:Treatment Outcome