title: Low prevalence of anti-small ubiquitin-like modifier activating enzyme antibodies in dermatomyositis patients.
abstract: BACKGROUND
  The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in European Caucasians.
  
  
  OBJECTIVE
  This study investigates the frequency and clinical characteristics of anti-SAE autoantibodies in Japanese patients with DM. Sera from 110 Japanese patients, including 13 with juvenile DM, were screened for anti-SAE antibodies by enzyme-linked immunosorbent assays. Positive sera were further examined by immunoblotting of the immunoprecipitates.
  
  
  RESULTS
  Only two patients (1.8%) were confirmed to have anti-SAE antibodies, and neither of these two patients had amyopathic or juvenile DM. One patient with anti-SAE had DM complicated with pulmonary arterial hypertension, and the other had cancer-associated DM. Both had hallmark cutaneous manifestations of DM.
  
  
  CONCLUSIONS
  This is the first report of anti-SAE antibodies from an Asian single center cohort. Although Japanese patients with anti-SAE antibodies have a clinical phenotype similar to that of Caucasian patients, their frequency was lower in the Japanese patients than in the previously reported Caucasian patients.
authors.affiliation: Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan. ymuro@med.nagoya-u.ac.jp
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Muro
authors.forename: Kazumitsu
authors.initials: K
authors.lastname: Sugiura
authors.forename: Masashi
authors.initials: M
authors.lastname: Akiyama
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003882:Dermatomyositis / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications; D007223:Infant; D008297:Male; D008875:Middle Aged; D044764:Ubiquitin-Activating Enzymes / Q000276:immunology*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D044764:Ubiquitin-Activating Enzymes