title: Distinctive age-related temporal cortical thinning in asymptomatic granulin gene mutation carriers.
abstract: Studies in asymptomatic granulin gene (GRN) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinical GRN mutation carriers and to study the relationship of CTh with cognitive performance in GRN mutation carriers. We calculated CTh maps in 13 asymptomatic carriers of the c.709-1G>A GRN mutation and 13 age- and sex-matched healthy subjects. Asymptomatic GRN mutation carriers presented different patterns of age-related cortical thinning in the right superior temporal and middle temporal gyri and the banks of the superior temporal sulcus bilaterally when compared with controls. Cortical thickness was correlated with neuropsychological test scores: Trail Making Tests A and B, and the Boston Naming Test. Distinctive age-related cortical thinning in asymptomatic GRN mutation carriers in lateral temporal cortices suggests an early and disease-specific effect in these areas.
authors.affiliation: Cognitive Disorders Unit, Department of Neurology, Hospital Universitario Donostia, San Sebastian, Gipuzkoa, Spain. fermin.morenoizco@osakidetza.net
authors.forename: Fermín
authors.initials: F
authors.lastname: Moreno
authors.forename: Roser
authors.initials: R
authors.lastname: Sala-Llonch
authors.forename: Myriam
authors.initials: M
authors.lastname: Barandiaran
authors.forename: Raquel
authors.initials: R
authors.lastname: Sánchez-Valle
authors.forename: Ainara
authors.initials: A
authors.lastname: Estanga
authors.forename: David
authors.initials: D
authors.lastname: Bartrés-Faz
authors.forename: Andone
authors.initials: A
authors.lastname: Sistiaga
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Alzualde
authors.forename: Esther
authors.initials: E
authors.lastname: Fernández
authors.forename: José Félix
authors.initials: JF
authors.lastname: Martí Massó
authors.forename: Adolfo
authors.initials: A
authors.lastname: López de Munain
authors.forename: Begoña
authors.initials: B
authors.lastname: Indakoetxea
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000235:genetics* / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D057174:Frontotemporal Lobar Degeneration / Q000235:genetics* / Q000473:pathology*; D006579:Heterozygote; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D000077153:Progranulins
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins