title: Roles for the sarco-/endoplasmic reticulum in cardiac myocyte contraction, protein synthesis, and protein quality control.
abstract: Although the function of the sarcoplasmic/endoplasmic reticulum (SR/ER) in cardiac contractile calcium handling is well established, its roles in protein synthesis, folding, and quality control in cardiac myocytes are not as clear. This review explores evidence suggesting that, in cardiac myocytes, protein synthesis and contractile calcium handling may be physically and functionally integrated.
authors.affiliation: San Diego State University Heart Institute and the Department of Biology, San Diego State University, San Diego, California, USA. cglembotski@sciences.sdsu.edu
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Glembotski
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000502:physiology*; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000502:physiology*; D014176:Protein Biosynthesis; D011786:Quality Control; D012519:Sarcoplasmic Reticulum / Q000502:physiology*