title: The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients.
abstract: We investigated the etiology of the attenuated niacin skin flush response in schizophrenia patients. Skin response to topical niacin of 0.1M, 0.01 M, 0.001 M, and 0.0001 M concentrations was rated using method of volumetric niacin response (VNR) and correlated to two functional A/G polymorphisms in genes: phospholipase A2 group IVA (BanI of the PLA2G4A), and rs689466 of the prostaglandin synthase-2 (PTGS2). We further tested the possible correlation between niacin response and fatty acid (FA) content of red blood cells (RBCs). We detected statistically significant but weak impact of both polymorphisms on niacin flush response in schizophrenia patients. The dosage of the G alleles of both polymorphisms was associated with higher VNR values, although each polymorphic variant accounted for only 1% of the overall flush response variability. Regarding FA content, both n-3 and n-6 polyunsaturated FAs (PUFAs) were significantly reduced in the patient group, but an association with niacin sensitivity was not detected.
authors.affiliation: Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Braće Branchetta 20, Rijeka 51000, Croatia.
authors.forename: Sergej
authors.initials: S
authors.lastname: Nadalin
authors.forename: Jasminka
authors.initials: J
authors.lastname: Giacometti
authors.forename: Suzana
authors.initials: S
authors.lastname: Jonovska
authors.forename: Draško
authors.initials: D
authors.lastname: Tomljanović
authors.forename: Alena
authors.initials: A
authors.lastname: Buretić-Tomljanović
mesh_terms: D000328:Adult; D051546:Cyclooxygenase 2 / Q000235:genetics*; D004912:Erythrocytes / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000172:deficiency*; D005260:Female; D005838:Genotype; D060005:Genotyping Techniques; D054513:Group IV Phospholipases A2 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009525:Niacin; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D012882:Skin Tests / Q000379:methods; D055815:Young Adult
chemical_list: D005231:Fatty Acids, Unsaturated; D009525:Niacin; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D054513:Group IV Phospholipases A2; C516389:PLA2G4A protein, human