title: Synthesis and antiviral activity of conformational analogues of leucamide A.
abstract: In order to study the effect of heterocyclic core conformational state of leucamide A on its anti-influenza virus A activity, five conformational analogues were prepared by replacing the Pro-Leu dipeptide in the molecule with various amino acids. The amino acids used were of 2 to 6 carbons. The results showed that these replacements not only changed the conformational relationship between the 4,2-bisheterocycle tandem pair and the third heterocycle, but also had dramatic effect on its activity against influenza virus A.
authors.affiliation: School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China.
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Wang
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Chen
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Ma
authors.forename: Min
authors.initials: M
authors.lastname: Gu
authors.forename: Min-Zhi
authors.initials: MZ
authors.lastname: Fan
authors.forename: Jing-Ya
authors.initials: JY
authors.lastname: Li
authors.forename: Bainian
authors.initials: B
authors.lastname: Feng
authors.forename: Fa-Jun
authors.initials: FJ
authors.lastname: Nan
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects*; D007251:Influenza, Human / Q000188:drug therapy*; D008968:Molecular Conformation; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D010456:Peptides, Cyclic; C470214:leucamide A