title: Donor-transmitted malignancy in a liver transplant recipient: a case report and review of literature.
abstract: Donor-transmitted malignancy is a rare complication of organ transplantation. This case illustrates a donor-transmitted adenocarcinoma in a patient 11 months after an orthotopic liver transplant for cryptogenic cirrhosis and hepatocellular carcinoma (HCC). Diagnosis of donor-transmitted malignancy may be challenging and can be confused with HCC recurrence. A timely diagnosis is crucial as a delay may limit treatment options. Biopsy of newly found liver lesions and the use of karyotypic and microsatellite analysis may be essential for diagnosis. Protocols should be in place to help recognize and limit the incidence of donor-transmitted malignancy.
authors.affiliation: Division of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of Medicine, Johns Hopkins University, 600 N. Wolfe Street, Blalock 459, Baltimore, MD 21287, USA. bkim53@jhmi.edu
authors.forename: Brian
authors.initials: B
authors.lastname: Kim
authors.forename: Tinsay
authors.initials: T
authors.lastname: Woreta
authors.forename: Po-Hung
authors.initials: PH
authors.lastname: Chen
authors.forename: Berkeley
authors.initials: B
authors.lastname: Limketkai
authors.forename: Andrew
authors.initials: A
authors.lastname: Singer
authors.forename: Nabil
authors.initials: N
authors.lastname: Dagher
authors.forename: Andrew
authors.initials: A
authors.lastname: Cameron
authors.forename: Ming-Tseh
authors.initials: MT
authors.lastname: Lin
authors.forename: Ihab
authors.initials: I
authors.lastname: Kamel
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gurakar
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000601:surgery; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male