title: Hepatitis C genotype 1 mosaic vaccines are immunogenic in mice and induce stronger T-cell responses than natural strains.
abstract: Despite improved hepatitis C virus (HCV) treatments, vaccines remain an effective and economic option for curtailing the epidemic. Mosaic protein HCV genotype 1 vaccine candidates designed to address HCV diversity were immunogenic in mice. They elicited stronger T-cell responses to NS3-NS4a and E1-E2 proteins than did natural strains, as assessed with vaccine-matched peptides.
authors.affiliation: Los Alamos National Laboratory, Los Alamos, New Mexico, USA. kyusim@lanl.gov
authors.forename: Karina
authors.initials: K
authors.lastname: Yusim
authors.forename: Rebecca
authors.initials: R
authors.lastname: Dilan
authors.forename: Erica
authors.initials: E
authors.lastname: Borducchi
authors.forename: Kelly
authors.initials: K
authors.lastname: Stanley
authors.forename: Elena
authors.initials: E
authors.lastname: Giorgi
authors.forename: William
authors.initials: W
authors.lastname: Fischer
authors.forename: James
authors.initials: J
authors.lastname: Theiler
authors.forename: Joseph
authors.initials: J
authors.lastname: Marcotrigiano
authors.forename: Bette
authors.initials: B
authors.lastname: Korber
authors.forename: Dan H
authors.initials: DH
authors.lastname: Barouch
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology* / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology*; D014611:Vaccination; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D017361:Viral Nonstructural Proteins / Q000276:immunology; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D000914:Antibodies, Viral; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; D014761:Viral Hepatitis Vaccines; D017361:Viral Nonstructural Proteins; C087035:E1 protein, Hepatitis C virus; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases