title: Clinical characteristics of patients with tuberculosis-destroyed lung.
abstract: METHODS
  Multicentre study.
  
  
  OBJECTIVE
  To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB.
  
  
  METHODS
  We reviewed patients with TB-destroyed lung between May 2005 and June 2011.
  
  
  RESULTS
  A total of 595 patients from 21 hospitals  were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5% were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1)),  FEV(1)/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26% ± 0.79), 1.16 ± 0.02 l (49.05% ± 0.84), 58.03% ± 0.70, 5.70% ± 0.34, and 0.40 ± 0.04. The number of lobes involved was  significantly correlated with FVC and FEV(1), and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age,  initial FEV(1) (%) and number of exacerbations during follow-up were independent factors affecting change in FEV(1).
  
  
  CONCLUSIONS
  Decreased lung function with exacerbation, and progressive decline of FEV(1) were observed in patients with TB-destroyed lung.
authors.affiliation: Department of Internal Medicine, Seoul St. Mary's Hospital, Catholic University of Korea, Seoul, Korea.
authors.forename: C K
authors.initials: CK
authors.lastname: Rhee
authors.forename: K H
authors.initials: KH
authors.lastname: Yoo
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: M J
authors.initials: MJ
authors.lastname: Park
authors.forename: W J
authors.initials: WJ
authors.lastname: Kim
authors.forename: Y B
authors.initials: YB
authors.lastname: Park
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authors.initials: YI
authors.lastname: Hwang
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.forename: J Y
authors.initials: JY
authors.lastname: Jung
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authors.initials: JY
authors.lastname: Moon
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authors.initials: YK
authors.lastname: Rhee
authors.forename: H K
authors.initials: HK
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authors.forename: J H
authors.initials: JH
authors.lastname: Lim
authors.forename: H Y
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authors.forename: S W
authors.initials: SW
authors.lastname: Lee
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: H K
authors.initials: HK
authors.lastname: Yoon
authors.forename: J W
authors.initials: JW
authors.lastname: Kim
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: Y K
authors.initials: YK
authors.lastname: Kim
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authors.initials: YM
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authors.forename: S D
authors.initials: SD
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000368:Aged; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000503:physiopathology; D012189:Retrospective Studies; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000473:pathology* / Q000503:physiopathology