title: [The renal artery resistive index is an integral marker of renal dysfunction in patients with chronic heart failure].
abstract: OBJECTIVE
  to study renal hemodynamic disorders in patients with Functional Classes (FC) II-IV chronic heart failure (CHF), by estimating the peripheral renal artery resistive index (RI), to reveal relationships to other hemodynamic parameters and markers of chronic kidney diseases and with the presence of infectious, inflammatory, and metabolic renal comorbidity in the patient.
  
  
  METHODS
  Sixty-eight patients with FC II-IV CHF were examined. Renal hemodynamics was studied using renal artery duplex scanning; cardiac morphofunctional parameters were explored by echocardiography (EchoCG). The markers of renal lesion were examined using laboratory tests and the Cockcroft-Gault and abridged Modification of Diet in Renal Disease 1 (MDRD1) formulas for estimating the glomerular filtration rate.
  
  
  RESULTS
  The patients with FC II-IV CHF were noted to have renal blood flow disorder that was progressive with higher FC CHF. Tubulointerstitial renal comorbidity in patients with CHF has a statistically significant impact both on the degree of proteinuria, the reduction of renal filtration function, and the parameters of distal renal blood flow. RI showed a stronger correlation with the degree of renal dysfunction and the markers of endothelial dysfunction than with the parameters of central hemodynamics and EchoCG.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Kovaleva
authors.forename: A A
authors.initials: AA
authors.lastname: Kirichenko
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D015897:Comorbidity; D018450:Disease Progression; D004452:Echocardiography / Q000379:methods; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007239:Infections / Q000150:complications; D007249:Inflammation / Q000150:complications; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D012079:Renal Circulation; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D012720:Severity of Illness Index; D013223:Statistics as Topic; D018616:Ultrasonography, Doppler, Duplex / Q000379:methods*; D014655:Vascular Resistance
chemical_list: D015415:Biomarkers