title: Genome sequencing and analysis of Salmonella enterica serovar Typhi strain CR0063 representing a carrier individual during an outbreak of typhoid fever in Kelantan, Malaysia.
abstract: Salmonella Typhi is a human restricted pathogen with a significant number of individuals as asymptomatic carriers of the bacterium. Salmonella infection can be effectively controlled if a reliable method for identification of these carriers is developed. In this context, the availability of whole genomes of carrier strains through high- throughput sequencing and further downstream analysis by comparative genomics approaches is very promising. Herein we describe the genome sequence of a Salmonella Typhi isolate representing an asymptomatic carrier individual during a prolonged outbreak of typhoid fever in Kelantan, Malaysia. Putative genomic coordinates relevant in pathogenesis and persistence of this carrier strain are identified and discussed.
authors.affiliation: Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India. ahmed.nizi@gmail.com.
authors.forename: Ramani
authors.initials: R
authors.lastname: Baddam
authors.forename: Narender
authors.initials: N
authors.lastname: Kumar
authors.forename: Sabiha
authors.initials: S
authors.lastname: Shaik
authors.forename: Tiruvayipati
authors.initials: T
authors.lastname: Suma
authors.forename: Soo Tein
authors.initials: ST
authors.lastname: Ngoi
authors.forename: Kwai-Lin
authors.initials: KL
authors.lastname: Thong
authors.forename: Niyaz
authors.initials: N
authors.lastname: Ahmed