title: Risk stratification for invasive aspergillosis in immunocompromised patients.
abstract: Severe prolonged neutropenia, allogeneic hematopoietic stem cell or solid-organ transplantation, corticosteroids or other T cell suppressive agents, and other severe immunosuppressive factors have for many years been considered to predispose patients to invasive aspergillosis. Other conditions such as impaired innate immunity, diabetes, renal impairment, progression of the underlying malignancy, prior respiratory disease, and nosocomial or environmental exposure to fungal spores or climatic factors have recently been considered additional risk factors of invasive aspergillosis. The multiplicity of risk factors as well as the obvious synergy between them renders risk stratification difficult. An international, large-scale, multicenter, epidemiological study is necessary to develop a risk score.
authors.affiliation: Department of Oncology and Hematology, Hôpital de Hautepierre, Strasbourg, France. raoul.herbrecht@chru-strasbourg.fr
authors.forename: Raoul
authors.initials: R
authors.lastname: Herbrecht
authors.forename: Pierre
authors.initials: P
authors.lastname: Bories
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Moulin
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Ledoux
authors.forename: Valérie
authors.initials: V
authors.lastname: Letscher-Bru
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D016867:Immunocompromised Host; D009503:Neutropenia / Q000209:etiology / Q000276:immunology; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents