title: Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis.
abstract: OBJECTIVE
  To explore the differences between women with endometriosis associated ovarian cancer and typical epithelial ovarian cancer.
  
  
  METHODS
  The medical charts of total 226 patients with epithelial ovarian cancer treated at Peking Union Medical College Hospital between March 2011 and March 2012 were reviewed. Histology evaluation determined endometriosis associated ovarian cancer (n = 17) or non-endometriosis associated ovarian cancer (n = 209).
  
  
  RESULTS
  Compared with non-endometriosis associated ovarian cancer, patients with endometriosis associated ovarian cancer were proved: (1) to be younger and more likely to be premenopausal at diagnosis of epithelial ovarian cancer (P = .03 and .005, respectively); (2) to have lower preoperative serum level of Ca125 (mean: 122.9 vs 1377.5 U/mL, P < .001) and more likely to display normal Ca125 level (P < .001); (3) to be identified at the earlier stage (stage I, P < .001); (4) to have completely different distribution of histological subtypes (significant overrepresentation of clear cell and endometrioid carcinoma).
  
  
  CONCLUSIONS
  As such, patients with endometriosis associated ovarian cancer differ from non-endomertiosis associated ovarian cancer in many of their critical clinical and biologic characteristics.
authors.affiliation: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, P.R. China. wangshu219@hotmail.com
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Qiu
authors.forename: Jing He
authors.initials: JH
authors.lastname: Lang
authors.forename: Keng
authors.initials: K
authors.lastname: Shen
authors.forename: Jia Xin
authors.initials: JX
authors.lastname: Yang
authors.forename: Hui Fang
authors.initials: HF
authors.lastname: Huang
authors.forename: Ling Ya
authors.initials: LY
authors.lastname: Pan
authors.forename: Ming
authors.initials: M
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood; D000077216:Carcinoma, Ovarian Epithelial; D004715:Endometriosis / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood / Q000209:etiology* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000097:blood / Q000209:etiology* / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D018394:CA-125 Antigen