title: Impaired energy-dependent processes underlie acute lead neuropathy.
abstract: BACKGROUND
  The mechanisms of lead neuropathy remain unexplained. A 48-year-old painter presented after undertaking a 3-week project of paint removal without the use of a protective mask. Two weeks later, he developed fasciculations, weakness, and muscle wasting. Nerve conduction studies demonstrated a motor neuropathy. A high serum lead level was identified, leading to a diagnosis of acute lead neuropathy.
  
  
  METHODS
  To investigate the pathophysiology, nerve excitability studies were undertaken acutely and in convalescence. Studies were undertaken at baseline and after the induction of limb ischemia.
  
  
  RESULTS
  Prominent abnormalities of excitability were noted, including a rightward shift of stimulus-response curves, reduction in depolarizing threshold electrotonus, and increased refractoriness. These changes became more severe with limb ischemia, and there was abolition of the superexcitable period and increased refractoriness.
  
  
  CONCLUSIONS
  We identified prominent changes in nerve excitability in lead neuropathy. The results suggest that there is impairment of axonal energy-dependent processes in lead neuropathy.
authors.affiliation: Translational Neuroscience Facility, School of Medical Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia. arun.krishnan@unsw.edu.au
authors.forename: Arun V
authors.initials: AV
authors.lastname: Krishnan
authors.forename: Susanna B
authors.initials: SB
authors.lastname: Park
authors.forename: William
authors.initials: W
authors.lastname: Huynh
authors.forename: Cindy S-Y
authors.initials: CS
authors.lastname: Lin
authors.forename: Robert D
authors.initials: RD
authors.lastname: Henderson
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Kiernan
mesh_terms: D004558:Electric Stimulation; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D007855:Lead Poisoning / Q000150:complications*; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology*; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D011115:Polyneuropathies / Q000150:complications*