title: Combinatorial synthesis of photo-crosslinked biodegradable networks.
abstract: OBJECTIVE
  Photo-crosslinking is a technique that can accelerate the development of novel polymeric biomaterials.
  
  
  METHODS
  Here we show the development of a combinatorial platform to synthesize numerous synthetic biodegradable and biocompatible networks by photo-crosslinking mixtures of macromers.
  
  
  RESULTS
  Combinations of dimethacrylate-terminated macromers based on hydrophobic D,L-lactide (DLLA), trimethylene carbonate (TMC), epsilon-caprolactone (CL), and hydrophilic polyethylene glycol (PEG) were crosslinked into polymer networks with widely differing properties. The interaction of cells with the network surfaces was assessed by an in vitro cell seeding experiment in which cell proliferation was assessed using a DNA proliferation assay.
  
  
  CONCLUSIONS
  In this way, a hydrophilic material was identified that unexpectedly supported the proliferation of cells very well.
authors.affiliation: MIRA Institute for Biomedical Technology and Technical Medicine, Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands. E.Zant@utwente.nl
authors.forename: Erwin
authors.initials: E
authors.lastname: Zant
authors.forename: Mirjam J
authors.initials: MJ
authors.lastname: Bosman
authors.forename: Dirk W
authors.initials: DW
authors.lastname: Grijpma
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002208:Caproates / Q000737:chemistry; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004146:Dioxanes / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007783:Lactones / Q000737:chemistry; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D001672:Biocompatible Materials; D002208:Caproates; D004146:Dioxanes; D007783:Lactones; D011092:Polyethylene Glycols; C443643:trimethylene carbonate; C121056:caprolactone; C091880:dilactide