title: Hepatopathy-thrombocytopenia syndrome after actinomycin-D therapy: treatment with defibrotide.
abstract: We report a case of administration compassionate use defibrotide in a 13-year-old girl with Sinusoidal Obstructive Syndrome and thrombocytopenia, also known as Hepatopathy--Thrombocytopenia Syndrome (HTS) during chemotherapy for Wilms' tumor.
authors.affiliation: Pediatric Intensive Care Unit, Miguel Servet University Hospital, Zaragoza, Spain. juanfranciscoml@gmail.com
authors.forename: Juan F
authors.initials: JF
authors.lastname: Martín-Lázaro
authors.forename: Daniel
authors.initials: D
authors.lastname: Palanca
authors.forename: Juan P
authors.initials: JP
authors.lastname: Garcia-Iñiguez
authors.forename: Paula
authors.initials: P
authors.lastname: Madurga
authors.forename: Ana
authors.initials: A
authors.lastname: Carboné
mesh_terms: D000293:Adolescent; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D057176:Compassionate Use Trials; D003609:Dactinomycin / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011089:Polydeoxyribonucleotides / Q000627:therapeutic use*; D013577:Syndrome; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D009396:Wilms Tumor / Q000188:drug therapy*
chemical_list: D011089:Polydeoxyribonucleotides; D003609:Dactinomycin; C036901:defibrotide