title: [Comparative study on application of Duo positive airway pressure and continuous positive airway pressure in preterm neonates with respiratory distress syndrome].
abstract: OBJECTIVE
  To determine whether early application of Duo positive airway pressure (DuoPAP), in comparison with nasal continuous positive airway pressure (NCPAP), can reduce the need for endotracheal intubation and mechanical ventilation and decrease the incidence of bronchopulmonary dysplasia (BPD) in preterm neonates with respiratory distress syndrome (RDS).
  
  
  METHODS
  In a single-center, randomized controlled trial, preterm neonates (gestational ages 30-35 weeks) with RDS were randomly assigned to receive DuoPAP (n=34) or NCPAP (n=33) within 6 hours of birth. If the two noninvasive ventilations were not effective, endotracheal intubation and mechanical ventilation were used, and pulmonary surfactant was administered as rescue therapy. The total invasive respiratory support rate and incidence of BPD within 24, 48 and 72 hours of birth were observed. The two groups were compared in terms of PaCO2, PaO2 and oxygenation index (OI) at 1, 12, 24, 48 and 72 hours after using the noninvasive respiratory support.
  
  
  RESULTS
  The total invasive respiratory support rates within 48 and 72 hours after birth were significantly lower in the DuoPAP group than in the NCPAP group (P<0.05). There was no difference in the incidence of BPD between the two groups (P>0.05). The OI in the DuoPAP group was significantly higher than in the NCPAP group at 1, 12, 24, 48 and 72 hours after noninlasive respiratory support (P<0.05). The DuoPAP group showed significantly lower PaCO2 than the NCPAP group at 1, 12, and 24 hours after noninvasive respiratory support (P<0.05). PaO2 was significantly higher in the DuoPAP group than in the NCPAP group at 1 and 12 hours after noninvasive respiratory support (P<0.05).
  
  
  CONCLUSIONS
  Compared with NCPAP, early application of DuoPAP can decrease the need for endotracheal intubation and mechanical ventilation in preterm neonates with RDS, showing promise for broad use.
authors.affiliation: Graduate School of Second Military Medical University, Shanghai, China.
authors.forename: Ling-Kai
authors.initials: LK
authors.lastname: Kong
authors.forename: Xiang-Yong
authors.initials: XY
authors.lastname: Kong
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Li
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Dong
authors.forename: Ming-Xia
authors.initials: MX
authors.lastname: Shang
authors.forename: Jing-Han
authors.initials: JH
authors.lastname: Chi
authors.forename: Ren-Xing
authors.initials: RX
authors.lastname: Huang
authors.forename: Yang
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jun-E
authors.initials: JE
authors.lastname: Ma
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Na
authors.initials: N
authors.lastname: Cai
authors.forename: Zhi-Chun
authors.initials: ZC
authors.lastname: Feng
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007385:Intermittent Positive-Pressure Ventilation / Q000379:methods*; D008297:Male; D063087:Noninvasive Ventilation / Q000379:methods; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*