title: Effect of nutritional status on human paraoxonase-1 activity in patients with chronic kidney disease.
abstract: METHODS
  The association between nutritional status, antioxidant human paraoxonase-1 (PON1) activity and low grade inflammation in hemodialized (HD) patients with chronic kidney disease (CKD) is unclear. The aim of this study was to determine PON1 paraoxonase and lactonase activities, ADMA, adiponectin and leptin concentrations, and to clarify the relationship between paraoxonase activity and a set of cardiovascular risk factors in malnourished, normal weight and obese HD patients; 114 HD patients with end-stage renal failure were enrolled.
  
  
  RESULTS
  Leptin levels were significantly higher and PON1 paraoxonase activities were significantly lower in obese patients compared to the other groups. Plasma adiponectin concentration was significantly lower in obese subjects compared to malnourished patients. Paraoxonase activity was negatively correlated with CRP level in HD and malnourished patients. Furthermore, we found significant inverse correlation between paraoxonase activity and BMI in the whole patient group. In multiple regression analysis, PON1 lactonase activity, CRP level and leptin concentration proved to be independent predictors of paraoxonase activity.
  
  
  CONCLUSIONS
  Despite the previous findings of reverse epidemiology for the mortality rate of HD patients, further studies are needed to clarify the effects of nutritional state on atherosclerosis in obese and malnourished patients with end-stage renal failure.
authors.affiliation: First Department of Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Sztanek
authors.forename: Ildikó
authors.initials: I
authors.lastname: Seres
authors.forename: Mariann
authors.initials: M
authors.lastname: Harangi
authors.forename: Lajos
authors.initials: L
authors.lastname: Lőcsey
authors.forename: Péter
authors.initials: P
authors.lastname: Koncsos
authors.forename: György
authors.initials: G
authors.lastname: Paragh
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood*; D050197:Atherosclerosis / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D015897:Comorbidity; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy; D020738:Leptin / Q000097:blood; D044342:Malnutrition / Q000097:blood / Q000453:epidemiology; D008875:Middle Aged; D009752:Nutritional Status; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D012044:Regression Analysis; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D002097:C-Reactive Protein; D043303:Aryldialkylphosphatase