title: Adult multipotent stromal cell technology for bone regeneration: a review.
abstract: Since the discovery of bone marrow derived stromal cell osteogenesis in the 1960s, tissue engineering with adult multipotent stromal cells (MSCs) has evolved as a promising approach to restore structure and function of bone compromised by injury or disease. To date, accelerated bone formation with MSCs has been demonstrated with a variety of tissue engineering strategies. Though MSC bone tissue engineering has advanced over the last few decades, limitations to clinical translation remain. A current review of this promising field is presented with a specific focus on equine investigations.
authors.affiliation: Laboratory for Equine and Comparative Orthopedic Research, Veterinary Clinical Sciences Department, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. mlopez@vetmed.lsu.edu
authors.forename: Mandi J
authors.initials: MJ
authors.lastname: Lopez
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Daigle
mesh_terms: D000818:Animals; D001846:Bone Development; D039902:Multipotent Stem Cells / Q000502:physiology* / Q000637:transplantation*; D010012:Osteogenesis / Q000502:physiology; D033581:Stem Cell Transplantation / Q000379:methods / Q000662:veterinary*; D020858:Tissue and Organ Harvesting / Q000379:methods / Q000662:veterinary