title: Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dibromo-8-quinolinolato-lanthanides.
abstract: Four mononuclear and iso-structural lanthanide complexes with 5,7-dibromo-8-quinolinol (H-BrQ): [Sm(BrQ)(3)(H(2)O)(2)]·0.5H(2)O (1), [Eu(BrQ)(3)(H(2)O)(2)]·1.33EtOH·0.33H(2)O (2), [Tb(BrQ)(3)(H(2)O)(2)]·0.5H(2)O (3), and [Dy(BrQ)(3)(H(2)O)(2)]·1.167EtOH·0.33H(2)O (4) were synthesized. Against BEL7404, SGC7901 and A549, complexes 1-4 exhibited enhanced cytotoxicity than H-BrQ or the corresponding lanthanide salts. The IC(50) values of complexes 1, 3 against BEL7404 were 9.6 ± 2.2 and 10.1 ± 2.6 μM, while that of complex 4 against SGC7901 was 7.5 ± 2.1 μM. Complexes 1-4 against A549 yielded IC(50) values in the range of 7.6 ± 1.5-29.6 ± 4.6 μM. The binding properties of H-BrQ and a model complex 1 to DNA were investigated by various methods. Results indicated that these lanthanide complexes interacted with DNA more strongly than free quinolinoline with intercalation being the most probable binding mode for both the complexes and quinolinoline.
authors.affiliation: State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Chemical Engineering, Guangxi Normal University, Yucai Road 15, Guilin 541004, PR China.
authors.forename: Yan-Cheng
authors.initials: YC
authors.lastname: Liu
authors.forename: Zhen-Feng
authors.initials: ZF
authors.lastname: Chen
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Song
authors.forename: Yan
authors.initials: Y
authors.lastname: Peng
authors.forename: Qi-Pin
authors.initials: QP
authors.lastname: Qin
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D002942:Circular Dichroism; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D020128:Inhibitory Concentration 50; D028581:Lanthanoid Series Elements / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
chemical_list: D056831:Coordination Complexes; D028581:Lanthanoid Series Elements; D015125:Oxyquinoline; D004247:DNA; C002276:broxyquinoline