title: [The analysis of the calcification in differentiating malignant thyroid neoplasm and the molecular mechanisms for the formation of the calcification].
abstract: The purpose of this review is to investigate the value of the calcification in differentiating malignant thyroid neoplasm and the molecular mechanisms for the formation of the calcification. Many published reports have proved the presence of calcifications in thyroid neoplasm and calcified nodules in these studies are more frequently malignant than noncalcified nodules. Through viewing the related references, we found that psammoma bodies (PBs), Runx2, osteocalcin, osteopontin, CD44v6 play an important role in the molecular mechanisms in the formation of the calcification in PTC. But further study is required for elucidating the mode of action.
authors.forename: Ting
authors.initials: T
authors.lastname: Gong
authors.forename: Jiadong
authors.initials: J
authors.lastname: Wang
mesh_terms: D002114:Calcinosis / Q000175:diagnosis* / Q000473:pathology; D050659:Core Binding Factor Alpha 1 Subunit / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D015675:Osteocalcin / Q000378:metabolism; D053495:Osteopontin / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D016606:Thyroid Nodule / Q000473:pathology
chemical_list: C112697:CD44v6 antigen; D050659:Core Binding Factor Alpha 1 Subunit; D018960:Hyaluronan Receptors; C493709:RUNX2 protein, human; D015675:Osteocalcin; D053495:Osteopontin