title: Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system.
abstract: Benzopyrano[2,3-b]pyridine is an important privileged medicinal scaffold. A three-component reaction of salicylaldehydes, thiols and 2 equiv of malononitrile that leads to the formation of a series of compounds incorporating 2,4-diamino-3-cyano-5-sulfanylbenzopyrano[2,3-b]pyridine framework is described. A proposed mechanism with the supporting experimental data is presented.
authors.affiliation: Department of Organic Chemistry, Timiryazev Agriculture Academy, Moscow 127550, Russia.
authors.forename: Nikolai M
authors.initials: NM
authors.lastname: Evdokimov
authors.forename: Artem S
authors.initials: AS
authors.lastname: Kireev
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Yakovenko
authors.forename: Mikhail Yu
authors.initials: MY
authors.lastname: Antipin
authors.forename: Igor V
authors.initials: IV
authors.lastname: Magedov
authors.forename: Alexander
authors.initials: A
authors.lastname: Kornienko