title: Case report: management of persistent dural anastomotic dehiscence in a patient treated with bevacizumab.
abstract: A 55-year-old woman with recurrent glioblastoma multiforme on palliative chemotherapy including Avastin, an angiogenesis inhibitor, presents with several episodes of bacterial meningitis secondary to a persistent cerebrospinal fluid (CSF) leak. Anastomotic dehiscence of the dura mater in the region of the previous craniotomy sites was evident. Attempts to repair the cranial CSF leak with external ventricular drain and ventriculoperitoneal shunt were unsuccessful. This patient underwent repair of the dural defects with a radial forearm free fascial flap, with consequent resolution of the CSF leak.A literature search was performed, and the available data on angiogenesis inhibitors and anastomotic dehiscence was reviewed, specifically focusing on delayed anastomotic dehiscence in patients receiving Avastin (bevacizumab). Although the potential complications of anastomotic dehiscence in patients receiving angiogenesis inhibitors are well documented, there is comparatively little documentation in the literature regarding delayed wound or anastomotic dehiscence. Twenty such cases were found cited in the literature; however, only one study was found which specifically considered angiogenesis inhibitors within the context of central nervous system malignancies.
authors.affiliation: From the Department of Plastics and Reconstructive Surgery, Prince of Wales Hospital, Randwick, New South Wales, Australia.
authors.forename: Kristen E
authors.initials: KE
authors.lastname: Elstner
authors.forename: Frederick K
authors.initials: FK
authors.lastname: Clarke
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Turner
mesh_terms: D057868:Anastomotic Leak / Q000139:chemically induced / Q000601:surgery*; D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D000068258:Bevacizumab; D065634:Cerebrospinal Fluid Leak; D002559:Cerebrospinal Fluid Rhinorrhea / Q000139:chemically induced / Q000601:surgery*; D003399:Craniotomy; D005260:Female; D058752:Free Tissue Flaps / Q000637:transplantation*; D006801:Humans; D008875:Middle Aged; D019651:Plastic Surgery Procedures / Q000379:methods*
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab