title: Validation of contrast-enhanced ultrasound-derived intensity-time gradients in submandibular gland sialolithotomy patients.
abstract: Contrast-enhanced ultrasound (CE-US)-derived intensity-time gradients (ITGs) can be used for noninvasive monitoring of extracorporeal shock wave sialolithotripsy effects in chronic sialolithiasis-related sialadenitis. Aim of this trial was to further validate CE-US as an independent and quantitative diagnostic tool for sialolithotomy efficacy. In this prospective clinical phase II evidence level c study perfusion in patients (n = 10) with unilateral sialolithiasis of the submandibular gland was quantitatively analyzed by CEUS before and after sialolithotomy comparing with the contralateral disease-free gland. A visual analog scale (VAS) scoring clinical complaints was correlated with CE-US-derived ITGs. Furthermore, ITG ratios reflecting values from the contralateral side and the diseased side were calculated. VAS documented significantly reduced clinical complaints after sialolithotomy indicative of a successful treatment. VAS data significantly correlated with CE-US-derived ITGs. In addition, ITG ratios were significantly increased after sialolithotomy. In conclusion, CE-US-derived ITGs and ITG ratios appear as independent and valid quantitative parameters of sialolithotomy efficacy.
authors.affiliation: Department of Otorhinolaryngology, University of Munich (LMU), Marchioninistr. 15, 81377 Munich, Germany. vanessa.siedek@med.uni-muenchen.de
authors.forename: Vanessa
authors.initials: V
authors.lastname: Siedek
authors.forename: Margarita
authors.initials: M
authors.lastname: Rytvina
authors.forename: Laura V
authors.initials: LV
authors.lastname: Klotz
authors.forename: Alexander
authors.initials: A
authors.lastname: Berghaus
authors.forename: Dirk-André
authors.initials: DA
authors.lastname: Clevert
authors.forename: Sebastian
authors.initials: S
authors.lastname: Strieth
mesh_terms: D000328:Adult; D000368:Aged; D000772:Anesthesia, Local; D003287:Contrast Media; D005260:Female; D019220:High-Energy Shock Waves; D006801:Humans; D008297:Male; D008875:Middle Aged; D015494:Salivary Gland Calculi / Q000000981:diagnostic imaging* / Q000628:therapy*; D012720:Severity of Illness Index; D012793:Sialadenitis / Q000000981:diagnostic imaging* / Q000628:therapy*; D013363:Submandibular Gland; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color
chemical_list: D003287:Contrast Media