title: Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing.
abstract: Polyethylene oxide (Polyox) and carrageenan based solvent cast films have been formulated as dressings for drug delivery to wounds. Films plasticised with glycerol were loaded with streptomycin (30%, w/w) and diclofenac (10%, w/w) for enhanced healing effects in chronic wounds. Blank and drug loaded films were characterised by texture analysis (for mechanical and mucoadhesive properties), scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and Fourier transform infrared spectroscopy. In addition, swelling, in vitro drug release and antibacterial studies were conducted to further characterise the films. Both blank and drug loaded films showed a smooth, homogeneous surface morphology, excellent transparency, high elasticity and acceptable tensile (mechanical) properties. The drug loaded films showed a high capacity to absorb simulated wound fluid and significant mucoadhesion force which is expected to allow effective adherence to and protection of the wound. The films showed controlled release of both streptomycin and diclofenac for 72 h. These drug loaded films produced higher zones of inhibition against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli compared to the individual drugs zones of inhibition. Incorporation of streptomycin can prevent and treat chronic wound infections whereas diclofenac can target the inflammatory phase of wound healing to relieve pain and swelling.
authors.affiliation: Department of Pharmaceutical, Chemical & Environmental Sciences, School of Science, University of Greenwich at Medway, Central Avenue, Chatham Maritime, ME4 4TB, Kent, UK. J.S.Boateng@gre.ac.uk
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Boateng
authors.forename: Harshavardhan V
authors.initials: HV
authors.lastname: Pawar
authors.forename: John
authors.initials: J
authors.lastname: Tetteh
mesh_terms: D000268:Adhesiveness; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D002351:Carrageenan / Q000737:chemistry; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage* / Q000494:pharmacology; D016503:Drug Delivery Systems; D004548:Elasticity; D005990:Glycerol / Q000737:chemistry; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D010968:Plasticizers / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013307:Streptomycin / Q000008:administration & dosage* / Q000494:pharmacology; D013499:Surface Properties; D013718:Tensile Strength; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D010968:Plasticizers; D012997:Solvents; D004008:Diclofenac; D011092:Polyethylene Glycols; D002351:Carrageenan; D005990:Glycerol; D013307:Streptomycin