title: [Paracetamol. Efficacious and safe for all ages].
abstract: Paracetamol has become a focus of attention as being unsafe due to hepatic toxicity and market withdrawal or prescription status is presently under discussion in Germany. This drug is, however, effective and safe if notes of caution are applied. In Germany 38 fatal cases of analgesic poisoning were observed in 2010, only 4 of which were due to paracetamol and 16 were caused by diclofenac and ibuprofen. Alternative pain medications are obviously much less safe, in particular given the additional risk of sometimes fatal gastrointestinal bleeding and cardiovascular side effects. This review extensively analyzes the safety record of paracetamol and applies these findings to the treatment of elderly people. Even very elderly patients may be safely treated with this compound, although a dose limit of 3 g/day should be instituted. This renewed discussion was triggered by the uncontrolled availability of paracetamol in the USA but observations from this country should not be generalized and applied to the German situation and objective reasoning should be re-installed.
authors.affiliation: Klinische Pharmakologie Mannheim, Zentrum für Gerontopharmakologie, Medizinische Fakultät Mannheim, Universität Heidelberg, Maybachstr. 14, 68169, Mannheim, Deutschland. martin.wehling@medma.uni-heidelberg.de
authors.forename: M
authors.initials: M
authors.lastname: Wehling
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects* / Q000506:poisoning / Q000627:therapeutic use*; D000367:Age Factors; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects* / Q000506:poisoning / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D002423:Cause of Death; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000401:mortality; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D062787:Drug Overdose / Q000401:mortality; D005858:Germany; D006801:Humans; D010147:Pain Measurement / Q000187:drug effects; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen