title: [Comparison of different G-CSF treatment effectiveness in experiments on irradiated mice].
abstract: In the experiments on F1 (CBA x C57BL) and BALB mice irradiated by 137Cs gamma-rays, preparations of unglycosilated G-SCF such as Neupogen and their domestic analogs Leucostim and Neupomax were investigated. The tests such as 9-day bone marrow cellularity (BMC) and endogenous CFUs, the neutrophile number restoration, the 30-day survival index have shown that all three preparations have an approximately equal effectiveness relating to acute radiation disease treatment and granulopoiesis stimulation after a 5-10 day consecutive administration following irradiation of mice at lethal and sublethal doses. We have come to the conclusion that Leucostim and Neupomax can be regarded as adequate substitutes for Neupogen.
authors.forename: L M
authors.initials: LM
authors.lastname: Rozhdestvenskiĭ
authors.forename: R A
authors.initials: RA
authors.lastname: Shchegoleva
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Deshevoĭ
authors.forename: N I
authors.initials: NI
authors.lastname: Lisina
authors.forename: B A
authors.initials: BA
authors.lastname: Titov
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D000069585:Filgrastim; D005720:Gamma Rays; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000187:drug effects; D019891:Leukopoiesis / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: D011837:Radiation-Protective Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim