title: A gold(III) porphyrin complex as an anti-cancer candidate to inhibit growth of cancer-stem cells.
abstract: A cytotoxic gold(III) complex of meso-tetraphenylporphyrin ([Au(TPP)]Cl, denoted gold-1a) blocks the self-renewal ability of cancer stem-like cells and shows appealing safety pharmacological profiles in rodents.
authors.affiliation: Department of Chemistry, State Key Laboratory of Synthetic Chemistry, and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.
authors.forename: Ching Tung
authors.initials: CT
authors.lastname: Lum
authors.forename: Alice Sze-Tsai
authors.initials: AS
authors.lastname: Wong
authors.forename: Marie C M
authors.initials: MC
authors.lastname: Lin
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006046:Gold / Q000737:chemistry*; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000187:drug effects; D011166:Porphyrins / Q000737:chemistry*; D012342:RNA, Small Nuclear / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D035683:MicroRNAs; D011166:Porphyrins; D012342:RNA, Small Nuclear; C405486:U6 small nuclear RNA; C409084:tetraphenylporphyrin; D006046:Gold