title: Morphological variations of hippocampal formation in epilepsy: image, clinical and electrophysiological data.
abstract: Morphological variations of hippocampal formation (MVHF) are observed in patients with epilepsy but also in asymptomatic individuals. The precise role of these findings in epilepsy is not yet fully understood. This study analyzes the hippocampal formation (HF) morphology of asymptomatic individuals (n = 30) and of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS) (n = 68), patients with malformations of cortical development (MCD) (n = 34), or patients with pure morphological variations of hippocampal formation (pure MVHF) (n = 12). Main clinical and electrophysiological data of patients with MVHF were also analyzed. Morphological variations of hippocampal formation are more frequently observed in patients with MCD than in patients with MTLE-HS or in asymptomatic individuals. Patients with pure morphological variations of hippocampal formation showed higher incidence of extratemporal seizure onset. Refractoriness seems to be more associated with other abnormalities, like HS or MCD, than with the HF variation itself. Thus, although morphological HF abnormalities might play a role in epileptogenicity, they seem to contribute less to refractoriness.
authors.affiliation: Departamento de Neurologia e Neurocirurgia, Hospital São Paulo, Universidade Federal de São Paulo, Rua Napoleão de Barros, 865, Vila Clementino, São Paulo/SP, Brazil. anahamad@gmail.com
authors.forename: Ana Paula Andrade
authors.initials: AP
authors.lastname: Hamad
authors.forename: Henrique
authors.initials: H
authors.lastname: Carrete
authors.forename: Marino Muxfeldt
authors.initials: MM
authors.lastname: Bianchin
authors.forename: Taissa
authors.initials: T
authors.lastname: Ferrari-Marinho
authors.forename: Katia
authors.initials: K
authors.lastname: Lin
authors.forename: Elza Márcia Targas
authors.initials: EM
authors.lastname: Yacubian
authors.forename: Luiz Celso Pereira
authors.initials: LC
authors.lastname: Vilanova
authors.forename: Eliana
authors.initials: E
authors.lastname: Garzon
authors.forename: Luís Otávio
authors.initials: LO
authors.lastname: Caboclo
authors.forename: Américo Ceiki
authors.initials: AC
authors.lastname: Sakamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D058256:Brain Waves / Q000502:physiology*; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D054220:Malformations of Cortical Development / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D059906:Neuroimaging; D012598:Sclerosis / Q000150:complications / Q000473:pathology; D055815:Young Adult