title: Successful treatment of pulmonary hypertension with beraprost and sildenafil after cord blood transplantation for infantile leukemia.
abstract: Pulmonary hypertension (PH) is an infrequently reported complication after hematopoietic stem cell transplantation, and its etiology and therapeutic strategies, especially in infants, remain unclear. We report a case of severe PH that developed in an infant with acute leukemia following administration of busulfan as a preconditioner for cord blood transplantation; the case was successfully treated with sildenafil and beraprost, which to our knowledge is the first reported successful use of this regimen in PH following transplantation for infantile leukemia. From a review of all previous reports, use of busulfan in infants may raise the risk of developing PH, and unlike definitive pulmonary veno-occlusive disease, PH in this subgroup may be reversible by early detection and treatment.
authors.affiliation: Department of Hematology/Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, Japan. kwnozomu@med.nagoya-u.ac.jp
authors.forename: Nozomu
authors.initials: N
authors.lastname: Kawashima
authors.forename: Masanobu
authors.initials: M
authors.lastname: Ikoma
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sekiya
authors.forename: Atsushi
authors.initials: A
authors.lastname: Narita
authors.forename: Nao
authors.initials: N
authors.lastname: Yoshida
authors.forename: Kimikazu
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Tameo
authors.initials: T
authors.lastname: Hatano
authors.forename: Koji
authors.initials: K
authors.lastname: Kato
mesh_terms: D036101:Cord Blood Stem Cell Transplantation; D004452:Echocardiography; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D007223:Infant; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines / Q000627:therapeutic use; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; C048081:beraprost; D000068677:Sildenafil Citrate; D011464:Epoprostenol