title: [Screening of bioactive components in epimedium for osteoporosis treatment by model population analysis].
abstract: Epimedium was obtained from different habitats, and their bioactive components for inhibiting RAW264.7 were screened by MTT assay. Results indicate that epimedium from different habitats displayed significant different activities. By means of model population analysis (MPA), a latent bioactive component, baohuoside-I was got. Activity of baohuoside-I wasvalidated and prior to icariin. MPA can be used for bioactive components screening.
authors.affiliation: Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Qian-Xu
authors.initials: QX
authors.lastname: Yang
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Xiao
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D003584:Cytological Techniques / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D034181:Epimedium / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010010:Osteoclasts / Q000166:cytology; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C060988:baohuoside I; C056599:icariin