title: Do X-linked diseases affect periodontal health?
abstract: Genetic factors play an important etiologic role in destructive periodontal diseases. There have been reports that sex chromosomes, especially disorders associated with the X chromosome, affect periodontal health. Although numerous X-linked diseases have been reported to be associated with various periodontal diseases, the association of gingivitis and/or periodontitis with these genetic syndromes should be considered tenuous and raises the question of whether the periodontal manifestation truly arises from an underlying X-linked genetic etiology. A brief overview of genetics in relation to sex chromosomes and putative X-linked genetic periodontal diseases is given.
authors.forename: Hua-Hong
authors.initials: HH
authors.lastname: Chien
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Hart
mesh_terms: D010520:Aggressive Periodontitis / Q000235:genetics; D050172:Genes, X-Linked / Q000235:genetics; D050173:Genes, Y-Linked / Q000235:genetics; D040181:Genetic Diseases, X-Linked / Q000235:genetics*; D005891:Gingivitis / Q000235:genetics; D006801:Humans; D010510:Periodontal Diseases / Q000235:genetics*; D010518:Periodontitis / Q000235:genetics