title: p120-Catenin: a novel regulator of innate immunity and inflammation.
abstract: p120-Catenin is the prototypic member of a subfamily of armadillo repeat domain proteins. Like its structural homologues, β- and γ-catenin, p120-catenin is an essential component of adherens junctions in endothelial cells and other polarized adherent cells. p120-Catenin binds directly to the cytoplasmic domain of cadherin and contributes to the regulation of cell-cell junctional integrity. Studies have demonstrated that p120-catenin plays important roles in cell-cell adhesion, embryonic development, cell proliferation and polarity, tumor cell migration, and cancer progression. However, recent insights have generated an entirely new perspective, suggesting that p120-catenin is implicated in the anti-inflammatory responses in the absence and presence of infection. This review summarizes the present knowledge and recent progress toward elucidating the novel role of p120-catenin in the regulation of innate immunity and inflammation.
authors.affiliation: Department of Anesthesiology, University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA. gchu@uic.edu
authors.forename: Guochang
authors.initials: G
authors.lastname: Hu
mesh_terms: D022005:Adherens Junctions; D000818:Animals; D051186:Armadillo Domain Proteins / Q000276:immunology / Q000378:metabolism*; D051177:Catenins / Q000378:metabolism*; D002448:Cell Adhesion; D051181:Desmosomal Cadherins / Q000378:metabolism; D042783:Endothelial Cells / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D056747:Immunomodulation; D007249:Inflammation / Q000378:metabolism*; D000095002:Delta Catenin
chemical_list: D051186:Armadillo Domain Proteins; D051177:Catenins; D051181:Desmosomal Cadherins; D000095002:Delta Catenin; C000722347:CTNND1 protein, human