title: Dose-related effect by maternal exposure to di-(2-ethylhexyl) phthalate plasticizer on inducing hypospadiac male rats.
abstract: The aim of this study was to evaluate dose-related effects on external genitalia of adult male offspring rats by maternal exposure to di-(2-ethylhexyl) phthalate (DEHP) plasticizer. Timed-pregnant rats were given DEHP by gastric intubation at doses of 0, 500, 750 or 1000mg/kg body weight/day from gestation day 12-19 to establish a hypospadiac rat model. The hypospadias was observed and the incidence in three DEHP dosage levels was 10.7%, 30.6% and 37.0%, respectively. With exposed dose increased, mild, moderate and severe hypospadiac rats were distinguished and an increased incidence of severe hypospadias was observed. The other reproductive lesions like reduced penile length and anogenital distance/body weight were observed. The results indicated the dose-related external genitalia teratogenic toxicity, and graded hypospadias on male offspring was resulted from high dosage DEHP maternal exposure.
authors.affiliation: Department of Pediatric Urology Surgery, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing 400014, China.
authors.forename: Mingyong
authors.initials: M
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Qiu
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Hua
authors.forename: Shengfen
authors.initials: S
authors.lastname: Tu
authors.forename: Yun
authors.initials: Y
authors.lastname: He
authors.forename: Sheng
authors.initials: S
authors.lastname: Wen
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Guanghui
authors.initials: G
authors.lastname: Wei
mesh_terms: D000818:Animals; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007021:Hypospadias / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008431:Maternal-Fetal Exchange; D010968:Plasticizers / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013723:Teratogens / Q000633:toxicity
chemical_list: D010968:Plasticizers; D013723:Teratogens; D004051:Diethylhexyl Phthalate