title: Chirp resonance spectroscopy of single lipid-coated microbubbles using an "acoustical camera".
abstract: An acoustical method was developed to study the resonance of single lipid-coated microbubbles. The response of 127 SonoVue microbubbles to a swept sine excitation between 0.5 and 5.5 MHz with a peak acoustic pressure amplitude of 70 kPa was measured by means of a 25 MHz probing wave. The relative amplitude modulation in the signal scattered in response to the probing wave is approximately equal to the radial strain induced by the swept sine excitation. An average damping coefficient of 0.33 and an average resonance frequency of 2.5 MHz were measured. Microbubbles experienced an average peak radial strain of 20%.
authors.affiliation: Department of Biomedical Engineering-ThoraxCenter, Erasmus Medical Center, Rotterdam, The Netherlands. renaud_gu@yahoo.fr
authors.forename: G
authors.initials: G
authors.lastname: Renaud
authors.forename: J G
authors.initials: JG
authors.lastname: Bosch
authors.forename: A F W
authors.initials: AF
authors.lastname: van der Steen
authors.forename: N
authors.initials: N
authors.lastname: de Jong
mesh_terms: D003198:Computer Simulation; D003287:Contrast Media; D016018:Least-Squares Analysis; D045423:Microbubbles; D017711:Nonlinear Dynamics; D009716:Numerical Analysis, Computer-Assisted; D010316:Particle Size; D010743:Phospholipids; D011312:Pressure; D012815:Signal Processing, Computer-Assisted; D013018:Sound Spectrography; D013459:Sulfur Hexafluoride; D013997:Time Factors; D014160:Transducers, Pressure; D014465:Ultrasonics / Q000295:instrumentation / Q000379:methods*; D014732:Vibration; D014867:Water
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D014867:Water; D013459:Sulfur Hexafluoride