title: Use of microneedle array devices for continuous glucose monitoring: a review.
abstract: Microneedle array devices provide the opportunity to overcome the barrier characteristics of the outermost skin layer, the stratum corneum. This novel technology can be used as a therapeutic tool for transdermal drug delivery, including insulin, or as a diagnostic tool providing access to dermal biofluids, with subsequent analysis of its contents. Over the last decade, the use of microneedle array technology has been the focus of extensive research in the field of transdermal drug delivery. More recently, the diagnostic applications of microneedle technology have been developed. This review summarizes the existing evidence for the use of microneedle array technology as biosensors for continuous monitoring of the glucose content of interstitial fluid, focusing also on mechanics of insertion, microchannel characteristics, and safety profile.
authors.affiliation: Diabetes, Endocrinology, and Metabolic Medicine, Imperial College London, London, United Kingdom.
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Laboudi
authors.forename: Nick S
authors.initials: NS
authors.lastname: Oliver
authors.forename: Anthony
authors.initials: A
authors.lastname: Cass
authors.forename: Desmond
authors.initials: D
authors.lastname: Johnston
mesh_terms: D000279:Administration, Cutaneous; D015374:Biosensing Techniques / Q000295:instrumentation; D015190:Blood Glucose Self-Monitoring / Q000379:methods*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D045604:Extracellular Fluid / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008845:Microinjections / Q000295:instrumentation*; D009339:Needles; D012867:Skin / Q000033:anatomy & histology / Q000378:metabolism*
chemical_list: D005947:Glucose