title: Modeling transcriptome dynamics in a complex world.
abstract: An accurate prediction of how extrinsic stimuli influence changes in gene expression has been challenging. In this issue, Nagano and colleagues successfully model genome-wide mRNA expression changes under variable environmental conditions in rice, raising hopes that scientists will soon be able to predict genome-wide transcriptional responses in a variety of organisms in uncontrolled real-world settings.
authors.affiliation: Departments of Medicine and Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Philipp A
authors.initials: PA
authors.lastname: Jaeger
authors.forename: Colleen
authors.initials: C
authors.lastname: Doherty
authors.forename: Trey
authors.initials: T
authors.lastname: Ideker