title: Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer's patches of mice and orients the immune response towards humoral immunity.
abstract: The large numbers of human intestinal microorganisms have a highly co-evolved relationship with the immune system. Dysbacteriosis of intestinal microbiota induces alterations of immune responses, and is closely related to disease development. Peyer's patches are immune sensors in intestine which exert essential functions during development of inflammatory disease. However, interactions between commensal bacteria and PPs have been poorly characterized. In this study, changes of lymphocyte subpopulations and production of cytokines in PPs of mice with intestinal dysbacteriosis were investigated. The ceftriaxone-induced dysbacteriosis caused a notable change in populations of T lymphocytes, their subpopulations in PPs and expressions of various cytokines. Our results suggest intestinal dysbacteriosis in mice reduces immune tolerance in PPs and orients immune response towards humoral immunity.
authors.affiliation: Department of Microecology, Dalian Medical University, No,9 Western Section, Lvshun South Street, Lvshunkou District, Dalian, 116044, China. shuwen@dlmedu.edu.cn.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Yinhui
authors.initials: Y
authors.lastname: Liu
authors.forename: Chuanzhou
authors.initials: C
authors.lastname: Gao
authors.forename: Shu
authors.initials: S
authors.lastname: Wen
authors.forename: Li
authors.initials: L
authors.lastname: Tang