title: Collecting duct carcinoma presenting uncommon metastatic features.
abstract: Collecting duct carcinoma (CDC) is a relatively rare subtype of renal cell carcinoma (RCC) which has an aggressive course with an extremely poor prognosis. Here we report on a case of CDC in a 29-year-old woman who showed rapid disease progression with some uncommon clinical features including extensive vertebral metastases and invasion of the spinal meninges. The patient developed paraplegia and died 9 months after the diagnosis of CDC. The features of the fulminant clinical course with the lesions of the meninges, although rare, are important for the accumulation of experience of this rare disease.
authors.affiliation: Department of Medical Oncology, Cancer Center, The State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Cheng
authors.forename: Ye
authors.initials: Y
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Men
authors.forename: Meng
authors.initials: M
authors.lastname: Qiu
authors.forename: Qiu
authors.initials: Q
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Bi
authors.forename: Ji-Yan
authors.initials: JY
authors.lastname: Liu
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000150:complications / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D017116:Low Back Pain / Q000209:etiology; D008159:Lumbar Vertebrae / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000150:complications / Q000556:secondary*; D009392:Nephrectomy; D010264:Paraplegia / Q000209:etiology; D013125:Spinal Neoplasms / Q000150:complications / Q000556:secondary*; D016312:Treatment Refusal
chemical_list: D014408:Biomarkers, Tumor