title: Association between interleukin-10 promoter polymorphisms and endometriosis: a meta-analysis.
abstract: To investigate the influence of the interleukin-10 gene promoter polymorphisms on the susceptibility of endometriosis, we examined the association by performing a meta-analysis. The PubMed, Embase, HuGE Navigator and CNKI were searched to identify eligible studies. We then conducted a meta-analysis to examine the association between interleukin-10 gene promoter polymorphisms and endometriosis. Eight case-control studies which examined the association between the IL-10 gene promoter polymorphisms and the susceptibility to endometriosis were finally included in the meta-analysis. Meta-analysis of the IL-10 -592 A/C polymorphisms showed a significant increased risk of endometriosis in the overall and Asian population in all genetic models and allele contrast. However, meta-analysis of the IL-10 -1082 A/G and IL-10 -819 T/C polymorphisms showed no association with endometriosis in all genetic models and allele contrast in the overall and Asian population samples. In addition, there was not a significant association between the IL-10 -592 A/C gene promoter polymorphisms with the severity of endometriosis. In conclusion, this meta-analysis suggests that the IL-10 -592 A/C polymorphisms conferred susceptibility to endometriosis. However, no associations were found between the IL-10 -1082 A/G and -819 T/C polymorphisms and susceptibility to endometriosis. Further studies are required to elucidate these associations more clearly.
authors.affiliation: Center of Reproductive Medicine, The West China Second University Hospital, Sichuan University, Sichuan, PR China. fw215@163.com
authors.forename: Wei
authors.initials: W
authors.lastname: Fan
authors.forename: Shangwei
authors.initials: S
authors.lastname: Li
authors.forename: Qiong
authors.initials: Q
authors.lastname: Chen
authors.forename: Zhongying
authors.initials: Z
authors.lastname: Huang
authors.forename: Qianhong
authors.initials: Q
authors.lastname: Ma
authors.forename: Zhun
authors.initials: Z
authors.lastname: Xiao
mesh_terms: D000483:Alleles; D004715:Endometriosis / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D017594:Publication Bias
chemical_list: D016753:Interleukin-10