title: Lack of an  association between the XRCC1 Arg399Gln polymorphism and gastric cancer based  on a meta-analysis.
abstract: Association  between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer  has been investigated; overall, the results have been inconclusive. We made a  meta-analysis of 13 case-control studies, including 3278 cases and 6243  controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were  used to assess this possible association. We found no evidence of a significant  association between the XRCC1 Arg399Gln polymorphism and gastric cancer risk  (in the additive inheritance model, OR = 0.986, 95%CI = 0.831-1.156, in the  dominant inheritance model, OR = 1.044, 95%CI = 0.890-1.224 and in the  recessive inheritance model, OR = 0.975, 95%CI = 0.894-1.063). We conclude that  the XRCC1 Arg399Gln polymorphism is not a risk factor for developing gastric  cancer.
authors.affiliation: Department of Anatomy, Harbin Medical University, Harbin, China.
authors.forename: B M
authors.initials: BM
authors.lastname: Liu
authors.forename: T M
authors.initials: TM
authors.lastname: Liu
authors.forename: B S
authors.initials: BS
authors.lastname: You
authors.forename: H Y
authors.initials: HY
authors.lastname: You
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: Y C
authors.initials: YC
authors.lastname: He
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D016001:Confidence Intervals; D004268:DNA-Binding Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human