title: Beyond the resistance: how novel neurobiological understandings of depression may lead to advanced treatment strategies.
abstract: For patients with depression, antidepressant response rates are generally low and residual symptoms can increase the risk of relapse. Poor response may be linked to increased inflammatory cytokines and obesity. Specifically targeting inflammation with adjunct l-methylfolate treatment may help patients with depression finally achieve remission. In this Webcast, experts examine the multi-directional relationship between obesity, inflammation, and depression, consider preliminary data on genetic alleles, and review evidence using l-methylfolate as a targeted therapy.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Texas, Huston, Texas, USA.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Jain
authors.forename: W Clay
authors.initials: WC
authors.lastname: Jackson
mesh_terms: D000328:Adult; D000483:Alleles; D000928:Antidepressive Agents / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003067:Coenzymes / Q000502:physiology; D018849:Controlled Clinical Trials as Topic; D016207:Cytokines / Q000097:blood; D004252:DNA Mutational Analysis; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D061218:Depressive Disorder, Treatment-Resistant / Q000188:drug therapy / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D004359:Drug Therapy, Combination; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008094:Lithium / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D009414:Nerve Growth Factors / Q000502:physiology; D009765:Obesity / Q000503:physiopathology; D056128:Obesity, Abdominal / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D013763:Tetrahydrofolates / Q000627:therapeutic use; D055105:Waist Circumference / Q000502:physiology
chemical_list: D000928:Antidepressive Agents; D003067:Coenzymes; D016207:Cytokines; D018836:Inflammation Mediators; D008094:Lithium; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009414:Nerve Growth Factors; D017367:Selective Serotonin Reuptake Inhibitors; D013763:Tetrahydrofolates; C573423:MTHFR protein, human; C005984:5-methyltetrahydrofolate