title: Arsenic in tube well water in Bangladesh: health and economic impacts and implications for arsenic mitigation.
abstract: A national drinking water quality survey conducted in 2009 furnished data that were used to make an updated estimate of chronic arsenic exposure in Bangladesh. About 20 million and 45 million people were found to be exposed to concentrations above the national standard of 50 µg/L and the World Health Organization's guideline value of 10 µg/L, respectively. From the updated exposure data and all-cause mortality hazard ratios based on local epidemiological studies, it was estimated that arsenic exposures to concentrations > 50 µg/L and 10-50 µg/L account for an annual 24,000 and perhaps as many as 19,000 adult deaths in the country, respectively. Exposure varies widely in the 64 districts; among adults, arsenic-related deaths account for 0-15% of all deaths. An arsenic-related mortality rate of 1 in every 16 adult deaths could represent an economic burden of 13 billion United States dollars (US$) in lost productivity alone over the next 20 years. Arsenic mitigation should follow a two-tiered approach: (i) prioritizing provision of safe water to an estimated 5 million people exposed to > 200 µg/L arsenic, and (ii) building local arsenic testing capacity. The effectiveness of such an approach was demonstrated during the United Nations Children's Fund 2006-2011 country programme, which provided safe water to arsenic-contaminated areas at a cost of US$ 11 per capita. National scale-up of such an approach would cost a few hundred million US dollars but would improve the health and productivity of the population, especially in future generations.
authors.affiliation: Lamont-Doherty Earth Observatory, Columbia University, Palisades, NY 10964, USA.
authors.forename: Sara V
authors.initials: SV
authors.lastname: Flanagan
authors.forename: Richard B
authors.initials: RB
authors.lastname: Johnston
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000328:Adult; D001151:Arsenic / Q000009:adverse effects / Q000032:analysis* / Q000592:standards; D020261:Arsenic Poisoning / Q000191:economics / Q000453:epidemiology / Q000401:mortality*; D001459:Bangladesh / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000401:mortality; D002423:Cause of Death; D004305:Dose-Response Relationship, Drug; D060766:Drinking Water / Q000009:adverse effects / Q000032:analysis* / Q000592:standards; D005260:Female; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007239:Infections / Q000139:chemically induced / Q000401:mortality; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D009369:Neoplasms / Q000139:chemically induced / Q000401:mortality; D011247:Pregnancy; D014874:Water Pollutants, Chemical / Q000009:adverse effects / Q000032:analysis* / Q000592:standards; D060986:Water Wells / Q000032:analysis* / Q000592:standards
chemical_list: D060766:Drinking Water; D014874:Water Pollutants, Chemical; D001151:Arsenic