title: δ-Catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1α and VEGF.
abstract: This study revealed that CWR22Rv-1 cells overexpressing δ-catenin display bigger tumor formation and higher angiogenic potentials than their matched control cells in the CAM assay. In addition, δ-catenin overexpression in CWR22Rv-1 cells results in increased hypoxia-inducible factor 1-alpha (HIF-1α and vascular endothelial growth factor (VEGF) expression. Furthermore, δ-catenin overexpression was found to enhance nuclear distribution of both β-catenin and HIF-1α in hypoxic condition, which is diminished by knockdown of δ-catenin. Our current study adds novel evidence regarding contribution of δ-catenin to the progression of prostate cancer.
authors.affiliation: College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju, South Korea.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: He
authors.forename: Hangun
authors.initials: H
authors.lastname: Kim
authors.forename: Taeyong
authors.initials: T
authors.lastname: Ryu
authors.forename: Youra
authors.initials: Y
authors.lastname: Kang
authors.forename: Jeong-Ae
authors.initials: JA
authors.lastname: Kim
authors.forename: Bo-Hyun
authors.initials: BH
authors.lastname: Kim
authors.forename: Jae-Hyuk
authors.initials: JH
authors.lastname: Lee
authors.forename: Keonwook
authors.initials: K
authors.lastname: Kang
authors.forename: Qun
authors.initials: Q
authors.lastname: Lu
authors.forename: Kwonseop
authors.initials: K
authors.lastname: Kim
mesh_terms: D000818:Animals; D051177:Catenins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D002642:Chick Embryo; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism*; D008297:Male; D009389:Neovascularization, Pathologic; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*; D000095002:Delta Catenin
chemical_list: D051177:Catenins; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000095002:Delta Catenin