title: [Genetic polymorphisms of ADH1B and ALDH-2 associated with risk of esophageal cancer: a meta-analysis].
abstract: OBJECTIVE
  To investigate the association of genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH-2) with risk of esophageal cancer (EC) in China.
  
  
  METHODS
  A comprehensive search of the database was performed to identify all case-control studies of ADH1B and ALDH-2 polymorphisms associated with esophageal cancer and their interactions with alcohol drinking. Meta-analysis was carried out for calculation of pooled OR value and its corresponding 95% CI.
  
  
  RESULTS
  The ADH1B * 1 and ALDH-2 * 2 allele were found to be associated to increased risk of EC, with odds ratios (OR) being 1. 24 (95% CI 1.10-1.41) and 3.05 (95% CI 1.94-4.77) for the ADH1B * 1/* 2 and ADH1B * 1/*1, and 1.6 (95% CI 1.01-2.03) and 0.77 (95% CI 0.28-2.09) for the ALDH-2 * 1/* 2 and ALDH-2 * 2/* 2 respectively. When compared with the ADH1B * 2/* 2 genotype in drinkers, the ADH1B * 1/* 2 + * 2/* 2 can increase risk of EC (OR = 3.13, 95% CI 2.17-4.51). ALDH-2 * 1/* 2 + * 2/* 2 showed an increased risk to EC among drinks compared with the ALDH-2 * 1/* 1 genotype (OR = 4.12, 95% CI 1.98-8.56).
  
  
  CONCLUSIONS
  ADH1B * 1 and ALDH-2 * 2 allele can increase the risk of EC in china, which can be modified by alcohol consumption.
authors.affiliation: College of Public Health, Zhengzhou University, Zhengzhou 450001, China. fjduan@126.com
authors.forename: Fujiao
authors.initials: F
authors.lastname: Duan
authors.forename: Chunhua
authors.initials: C
authors.lastname: Song
authors.forename: Shuli
authors.initials: S
authors.lastname: Cui
authors.forename: Longzhi
authors.initials: L
authors.lastname: Wang
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhen
authors.forename: Honghong
authors.initials: H
authors.lastname: Qu
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Kaijuan
authors.initials: K
authors.lastname: Wang
authors.forename: Jianying
authors.initials: J
authors.lastname: Zhang
authors.forename: Liping
authors.initials: L
authors.lastname: Dai
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000428:Alcohol Drinking / Q000009:adverse effects; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics; D002681:China / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial