title: A novel green gelatin-agar microencapsulation system with P. urinaria as an improved anti-A. niger model.
abstract: In this study, a novel green microencapsulation system was used to develop Phyllanthus urinaria (PU) extract containing microcapsules. Agar was used with gelatin as the wall matrix materials of microcapsules to prevent the use of toxic crosslinker formaldehyde. Microencapsulated PU extract was developed to improve the potential antifungal activities of PU water extracts. The active components and surface morphology of PU extract containing microcapsules were analyzed by liquid chromatography/mass spectrometry and scanning electron microscopy, respectively. The in vitro release study demonstrated that approximately 80% of drug was released after 120 h. PU loaded microcapsules were shown to have a stronger anti-Aspergillus niger activity than the free drug.
authors.affiliation: Institute of Textiles and Clothing and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Pik-Ling
authors.initials: PL
authors.lastname: Lam
authors.forename: Stanton Hon-Lung
authors.initials: SH
authors.lastname: Kok
authors.forename: Yiu-Wah
authors.initials: YW
authors.lastname: Ho
authors.forename: Raymond Siu-Ming
authors.initials: RS
authors.lastname: Wong
authors.forename: Gregory Yin-Ming
authors.initials: GY
authors.lastname: Cheng
authors.forename: Chor-Hing
authors.initials: CH
authors.lastname: Cheng
authors.forename: Kim-Hung
authors.initials: KH
authors.lastname: Lam
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.forename: Kenneth Ka-Ho
authors.initials: KK
authors.lastname: Lee
authors.forename: Chung-Hin
authors.initials: CH
authors.lastname: Chui
mesh_terms: D000362:Agar / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects / Q000472:pathogenicity; D002214:Capsules / Q000737:chemistry / Q000494:pharmacology; D004339:Drug Compounding; D005780:Gelatin / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D029803:Phyllanthus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D002214:Capsules; D010936:Plant Extracts; D005780:Gelatin; D000362:Agar