title: Impacts of acute imipramine treatment on plasma and brain amino acid metabolism in mice given graded levels of dietary chicken protein.
abstract: Several studies have shown a relationship between depression and animal protein intake. To evaluate whether the difference of dietary chicken protein levels induces an antidepressant-like effect and potentiates acute antidepressant effects, three levels of dietary chicken protein were used as the representative animal protein with imipramine used as the antidepressant. In addition, the effects of dietary chicken protein on brain metabolism were evaluated. Open field test (OFT) and forced swimming test (FST) were conducted on the 27th and 28th days, respectively. OFT and FST were not influenced by both imipramine and dietary protein levels. However, characteristic effects of imipramine treatment on brain monoamine metabolism were observed in the cerebral cortex and hypothalamus. In addition, dietary protein significantly increased taurine and L-ornithine levels even though these amino acids were not contained in the diets. In conclusion, the metabolism of several amino acids in the plasma and brain were altered by dietary chicken protein.
authors.affiliation: Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Higashi, Fukuoka, Japan.
authors.forename: Mao
authors.initials: M
authors.lastname: Nagasawa
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Murakami
authors.forename: Shozo
authors.initials: S
authors.lastname: Tomonaga
authors.forename: Mikako
authors.initials: M
authors.lastname: Sato
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takahata
authors.forename: Fumiki
authors.initials: F
authors.lastname: Morimatsu
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000596:Amino Acids / Q000097:blood / Q000378:metabolism*; D000821:Animal Feed; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D015306:Biogenic Monoamines / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002645:Chickens; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D009952:Ornithine / Q000378:metabolism; D011202:Poultry Products; D013654:Taurine / Q000378:metabolism
chemical_list: D000596:Amino Acids; D000929:Antidepressive Agents, Tricyclic; D015306:Biogenic Monoamines; D004044:Dietary Proteins; D013654:Taurine; D009952:Ornithine; D007099:Imipramine