title: YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: implications for breast cancer.
abstract: The proto-oncogenes YAP and TAZ have previously gained much attention as downstream effectors of Hippo tumour suppressor signalling. While the regulation of YAP/TAZ by MST/LATS kinases is reasonably well understood, the nature of factors functioning upstream of MST/LATS is yet to be elucidated in detail. A recent paper by Ma and co-workers defines a novel role for leukemia inhibitory factor receptor (LIFR) signalling upstream of the Hippo-YAP pathway in breast cancer metastasis. Moreover, a whole genome in vivo RNA interference screen by Lippmann and colleagues identified LIFR as a breast tumour suppressor. Here, we discuss the implications of these studies for breast cancer research and treatment.
authors.forename: Alexander
authors.initials: A
authors.lastname: Hergovich
mesh_terms: D000217:Acyltransferases; D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D016147:Genes, Tumor Suppressor; D000090683:Hippo Signaling Pathway; D006801:Humans; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism; D010750:Phosphoproteins / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D034622:RNA Interference; D053606:Receptors, OSM-LIF / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D053606:Receptors, OSM-LIF; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; D000217:Acyltransferases; C108675:TAFAZZIN protein, human; C092745:LATS1 protein, human; D017346:Protein Serine-Threonine Kinases; D020930:MAP Kinase Kinase Kinases; C093290:MAP3K10 protein, human