title: MicroRNA regulation of epithelial plasticity in cancer.
abstract: MicroRNAs (miRNAs) are small non-coding RNA molecules capable of regulating multiple target genes through repression of mRNA stability or translation. miRNAs regulate a wide variety of developmental and pathological processes, and many have oncogenic or tumor suppressor activity. Carcinoma cells can undergo changes resembling a partial or transient epithelial-mesenchymal transition (EMT) as part of the metastatic cascade. Numerous miRNAs regulate EMT by targeting genes that control epithelial or mesenchymal characteristics. The involvement of miRNAs in feedback loops with EMT-regulating transcription factors reveals a critical role in governing epithelial plasticity. In this review we summarize miRNAs involved in carcinoma cell plasticity.
authors.affiliation: Department of Pathology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: D'Amato
authors.forename: Erin N
authors.initials: EN
authors.lastname: Howe
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Richer
mesh_terms: D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D004847:Epithelial Cells / Q000473:pathology*; D025461:Feedback, Physiological; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D015820:Cadherins; C533896:MIRN200 microRNA, human; D035683:MicroRNAs; D014157:Transcription Factors