title: [Assessment on analgesic and anti-inflammatory effects of Tongjingbao optimal formula and analysis on its active components].
abstract: OBJECTIVE
  To assess the analgesic and anti-inflammatory effects of Tongjingbao optimal formula and analyze its active components.
  
  
  METHODS
  Animals were divided into the model group, the Tongjingbao granule group and the Tongjingbao optimal formula group. The mice dysmenorrhea model was induced by oxytocin, and their content of blood calcium and MDA, NO, PGE2 in uterus were determined to assess the analgesic and anti-inflammatory effects of different components in Tongjingbao optimal formula and their impacts.
  
  
  RESULTS
  All components of Tongjingbao optimal formula could extend the dysmenorrhea incubation period of mice with dysmenorrhea, reduce their average writhing time, increase the writhing inhibition rate, lessen the content of blood calcium and MDA, PGE2 in uterus, and enhance the content of NO in uterus.
  
  
  CONCLUSIONS
  All components of Tongjingbao optimal formula have the analgesic and anti-inflammatory effects, and different components show a synergistic effect in treating dysmenorrheal in many links.
authors.affiliation: Jiangsu Provincial Academy of Chinese Medicine, State Administration of Traditional Chinese Medicine, Nanjing 210028, China. cwyxz_love@126.com
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.forename: Xu-ying
authors.initials: XY
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Song
authors.forename: Zhen-hai
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Xiao-bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D000700:Analgesics / Q000008:administration & dosage* / Q000032:analysis; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000032:analysis; D004412:Dysmenorrhea / Q000188:drug therapy*; D005260:Female; D006801:Humans
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal