title: The use of canine-specific albumin in dogs with septic peritonitis.
abstract: OBJECTIVE
  To assess changes in serum albumin concentration (ALB), colloid osmotic pressure (COP), and Doppler blood pressure (DBP) following transfusion of 5% lyophilized canine-specific albumin (CSA) in hypoalbuminemic dogs following surgical source control for septic peritonitis.
  
  
  METHODS
  Prospective randomized clinical trial November 2009 - November 2010.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Fourteen client-owned dogs with hypoalbuminemia (<27 g/L [2.7 g/dL]) following surgical source control for septic peritonitis.
  
  
  METHODS
  Dogs were randomized to clinician-directed therapy (CDT) and CSA groups. Dogs enrolled in the CSA group received 800 mg/kg of CSA within 24 hours following surgical intervention.
  
  
  RESULTS
  At enrollment, ALB, COP, and DBP were not different between groups. ALB, COP, and DBP were significantly increased in the CSA group 2 hours following completion of the transfusion compared with the CDT group (P = 0.0234, 0.0078, 0.0156, respectively). In comparison to the CDT group, there was a significant change in ALB in the CSA group 24 hours after transfusion (P = 0.0039), but no difference in COP (P = 0.3914) or DBP (P = 0.5145). ALB was significantly higher in the CSA group at 24 hours compared with the CDT group (P = 0.0367) At the time of death or discharge, there was no difference between groups regarding ALB, COP, or DBP, but an association between ALB and survival was identified (P = 0.0273). One dog experienced tachypnea during transfusion of CSA; this dog died of unknown respiratory causes 120 hours after transfusion.
  
  
  CONCLUSIONS
  The administration of CSA in dogs with septic peritonitis results in an increase in ALB, COP, and DBP 2 hours after administration. An increase in ALB persisted at 24 hours compared with a CDT group. Administration of this product was not associated with owner-reported delayed adverse events in this population of dogs.
authors.affiliation: Department of Clinical Sciences, Veterinary Medical Center, University of Minnesota, St. Paul, MN 55108, USA. emcraft111@gmail.com
authors.forename: Elise M
authors.initials: EM
authors.lastname: Craft
authors.forename: Lisa L
authors.initials: LL
authors.lastname: Powell
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D034141:Hypoalbuminemia / Q000188:drug therapy / Q000662:veterinary; D008297:Male; D010538:Peritonitis / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality / Q000662:veterinary*; D018805:Sepsis / Q000662:veterinary*; D012709:Serum Albumin / Q000378:metabolism / Q000627:therapeutic use*; D013045:Species Specificity
chemical_list: D012709:Serum Albumin