title: Expression of nuclear factor kappa B and survivin in psoriasis.
abstract: Background and Objective. Suppression of apoptosis has been proposed as a mechanism responsible for epidermal thickness in psoriasis. Survivin is a member of the inhibitor of apoptosis family. Nuclear factor kappa B (NF-κB) is one of the transcriptional factors that regulate many genes affecting apoptosis. The aim of this study was to determine survivin and NF-κB expressions in psoriasis in comparison with normal epidermis. Patients and Methods. Immunohistochemical expressions of survivin and NF-κB were investigated in 41 psoriatic and 21 normal skin samples. Results. Diffuse nuclear survivin expression in all epidermal layers was seen in all of the psoriatic samples. NF-κB expression in different epidermal locations was seen in all of the psoriatic samples. Nuclear staining was positive in 40 psoriasis samples. Similar survivin and NF-κB expressions were observed in normal skin samples. Conclusion. Since similar expressions are seen in both normal and psoriatic epidermis, no important roles for survivin and NF-κB can be attributed in epidermal proliferation and thickness seen in psoriasis.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors.forename: Kamer
authors.initials: K
authors.lastname: Gunduz
authors.forename: Peyker
authors.initials: P
authors.lastname: Temiz
authors.forename: Gulsum
authors.initials: G
authors.lastname: Gencoglan
authors.forename: Isil
authors.initials: I
authors.lastname: Inanir
authors.forename: Arzu
authors.initials: A
authors.lastname: Catalkaya