title: Visual field improvement after pituitary tumor surgery in patients with McCune-Albright syndrome.
abstract: BACKGROUND
  McCune-Albright syndrome (MAS) is a rare, sporadic congenital disorder, in which optic neuropathy may cause devastating visual consequences. Pituitary adenoma with overproduction of growth hormone (GH) is present in approximately two-thirds of MAS patients, and its role in the pathogenesis of MAS-associated optic neuropathy has not been studied.
  
  
  METHODS
  Three MAS patients with GH-secreting pituitary adenoma and optic chiasm compression diagnosed between January 2008 and November 2010 were included in this case series. Transsphenoidal pituitary resection was performed in all 3 patients. Neuro-ophthalmologic evaluation was performed at presentation and every 6 months during follow-up.
  
  
  RESULTS
  Of the 3 patients, 2 were female and 1 was male; their ages ranged from 17 to 27 years. Visual acuity ranged from 20/20 to 20/200 before surgery and all had visual field loss. The patients were followed up for 6-18 months with substantial improvement in their visual fields.
  
  
  CONCLUSIONS
  GH-secreting pituitary adenoma may contribute to optic nerve damage, at least partially, in MAS patients. Pituitary surgery may be important for visual recovery in some MAS patients in whom there is compression of the optic chiasm.
authors.affiliation: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Ma
authors.forename: Chan
authors.initials: C
authors.lastname: Zhao
authors.forename: Renzhi
authors.initials: R
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Feng
authors.forename: Erqian
authors.initials: E
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: You
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Meifen
authors.initials: M
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhong
mesh_terms: D000236:Adenoma / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D009897:Optic Chiasm / Q000601:surgery; D009901:Optic Nerve Diseases / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D014786:Vision Disorders / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D014794:Visual Fields / Q000502:physiology*