title: Contribution of common genetic variants to antidepressant response.
abstract: BACKGROUND
  Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this.
  
  
  METHODS
  We estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data.
  
  
  RESULTS
  We find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response.
  
  
  CONCLUSIONS
  These results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.
authors.affiliation: Institute of Psychiatry, King's College London, London, United Kingdom. katherine.tansey@kcl.ac.uk
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Tansey
authors.forename: Michel
authors.initials: M
authors.lastname: Guipponi
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Hu
authors.forename: Enrico
authors.initials: E
authors.lastname: Domenici
authors.forename: Glyn
authors.initials: G
authors.lastname: Lewis
authors.forename: Alain
authors.initials: A
authors.lastname: Malafosse
authors.forename: Jens R
authors.initials: JR
authors.lastname: Wendland
authors.forename: Cathryn M
authors.initials: CM
authors.lastname: Lewis
authors.forename: Peter
authors.initials: P
authors.lastname: McGuffin
authors.forename: Rudolf
authors.initials: R
authors.lastname: Uher
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007206:Individuality; D010641:Phenotype; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents