title: Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy.
abstract: Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of CNS blood vessels but not in the brain parenchyma. In the past, treatment of cIVL with anthracycline-based regimens was unsatisfactory with very short survival times. In the case of cIVL presented here, high-dose methotrexate-based polychemotherapy according to the Bonn protocol plus rituximab therapy was successful and led to a complete clinical and MRI remission which is ongoing 29 months after diagnosis.
authors.affiliation: Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany. Ulrich.Herrlinger@ukb.uni-bonn.de.
authors.forename: Sied
authors.initials: S
authors.lastname: Kebir
authors.forename: Klaus
authors.initials: K
authors.lastname: Kuchelmeister
authors.forename: Pitt
authors.initials: P
authors.lastname: Niehusmann
authors.forename: Michael
authors.initials: M
authors.lastname: Nelles
authors.forename: Young
authors.initials: Y
authors.lastname: Kim
authors.forename: Sharmilan
authors.initials: S
authors.lastname: Thanendrarajan
authors.forename: Niklas
authors.initials: N
authors.lastname: Schäfer
authors.forename: Moritz
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authors.lastname: Stuplich
authors.forename: Frederic
authors.initials: F
authors.lastname: Mack
authors.forename: Björn
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authors.lastname: Scheffler
authors.forename: Horst
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authors.lastname: Urbach
authors.forename: Martin
authors.initials: M
authors.lastname: Glas
authors.forename: Ulrich
authors.initials: U
authors.lastname: Herrlinger