title: [Progress of osteogenic effect of strontium and its application in orthopaedics].
abstract: OBJECTIVE
  To review the research progress of the osteogenic effect of strontium (Sr) and its application in the orthopaedics.
  
  
  METHODS
  The recent literature concerning the osteogenic effect of Sr and its application in orthopaedics at home and abroad was extensively reviewed, and the research and development were summarized.
  
  
  RESULTS
  Both in vivo and in vitro studies showed that Sr could enhance bone formation and inhibit bone resorption. Clinically, Sr was applied for treatment of osteoporosis, composite biomaterials in tissue engineering, and treatment of bone tumors and bone metastases.
  
  
  CONCLUSIONS
  Sr is one important combined element of alternative materials in bone tissue engineering, and can strengthen the mechanical and biological properties of the bone replacement material, so it has some development potential in bone tissue engineering.
authors.affiliation: Department of Orthopaedics, the First People's Hospital of Yunnan Province, Kunming Yunnan, 650001, P.R.China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Yunkun
authors.initials: Y
authors.lastname: Lei
authors.forename: Zengdong
authors.initials: Z
authors.lastname: Meng
mesh_terms: D015519:Bone Density / Q000187:drug effects; D001847:Bone Diseases / Q000188:drug therapy*; D018786:Bone Substitutes; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects*; D010024:Osteoporosis / Q000188:drug therapy; D053244:Osteoprotegerin / Q000378:metabolism; D053245:RANK Ligand / Q000378:metabolism; D015398:Signal Transduction; D013324:Strontium; D023822:Tissue Engineering
chemical_list: D018786:Bone Substitutes; D053244:Osteoprotegerin; D053245:RANK Ligand; D013324:Strontium