title: The role of T-cells in the pathogenesis of myelodysplastic syndromes: passengers and drivers.
abstract: Although a burden of clinical and experimental data suggest the involvement of T-lymphocytes in the pathogenesis of myelodysplastic syndromes (MDS), the actual weight exerted by T-cells in this scenario is yet to be conclusively dissected. This brief review will try to further address this point, by running through the most relevant studies exploring the T-cell repertoire of MDS patients as well as the potential role of specific T-cell subsets such as regulatory T-cells and Th17 T-cells.
authors.affiliation: Department of Biomedical Sciences, University of Sassari, Sassari, Italy. cfozza@uniss.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Fozza
authors.forename: Maurizio
authors.initials: M
authors.lastname: Longinotti
mesh_terms: D006801:Humans; D009190:Myelodysplastic Syndromes / Q000276:immunology* / Q000378:metabolism* / Q000628:therapy; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*