title: Effects of Noscarna™ on hypertrophic scarring in the rabbit ear model: histopathological aspects.
abstract: In this study, we evaluated the effects of silicone-based gel on the healing of hypertrophic scars in the rabbit ear model. After 4-week application of silicone-based gel containing allantoin, dexpanthenol and heparin (Noscarna™) to scars in a rabbit ear model of hypertrophic scarring, significant improvements in hypertrophic scar healing and a great loss of skin pigment were observed compared to the non-treated control, base or silicone control-treated scars. Furthermore, histological analysis of Noscarna™-treated scars revealed a significant reduction in scar elevation index (SEI), anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization and fibroblasts compared to all control hypertrophic scars. Furthermore, Noscarna™ showed more favorable effects on hypertrophic scars than a commercial product, Contractubex®. Therefore, these results clearly demonstrated that the newly developed silicone-based gel, Noscarna™, could be a promising formulation as an effective therapeutic agent for hypertrophic scars.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Lee
authors.forename: Sae Kwang
authors.initials: SK
authors.lastname: Ku
authors.forename: Hyuk Jun
authors.initials: HJ
authors.lastname: Cho
authors.forename: Jeong Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Tran Tuan
authors.initials: TT
authors.lastname: Hiep
authors.forename: Sang Duk
authors.initials: SD
authors.lastname: Han
authors.forename: Bo Gyun
authors.initials: BG
authors.lastname: Kim
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Kang
authors.forename: Eui Seon
authors.initials: ES
authors.lastname: Do
authors.forename: Joon Ho
authors.initials: JH
authors.lastname: Jun
authors.forename: Sun Woo
authors.initials: SW
authors.lastname: Jang
authors.forename: Mi-Won
authors.initials: MW
authors.lastname: Son
authors.forename: Young Taek
authors.initials: YT
authors.lastname: Sohn
authors.forename: Han-Gon
authors.initials: HG
authors.lastname: Choi
authors.forename: Chul Soon
authors.initials: CS
authors.lastname: Yong
authors.forename: Jong Oh
authors.initials: JO
authors.lastname: Kim
mesh_terms: D000481:Allantoin / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D017439:Cicatrix, Hypertrophic / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004338:Drug Combinations; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits; D020034:Silicone Gels / Q000737:chemistry; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D012880:Skin Pigmentation / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D010936:Plant Extracts; D020034:Silicone Gels; C053099:allantoin, heparin, onion extract drug combination; D010205:Pantothenic Acid; C007288:dexpanthenol; D000481:Allantoin; D006493:Heparin