title: Analysis of the activation of the Nrf2-ARE pathway following optic nerve injury in mice.
abstract: OBJECTIVE
  The Nrf2-ARE pathway plays a cytoprotective role in many tissues,but its protective function in the optic nerve is unclear. The purpose of the study is to investigate the changes in activation of the Nrf2-ARE pathway following optic nerve injury (ONI) in mice.
  
  
  METHODS
  Using ONI mice models, the expression levels of Nrf2 in optic nerves were determined by real-time PCR at various time points.
  
  
  RESULTS
  The expression of Nrf2mRNA was significantly upregulated at 1 d after ONI, peaking at 30 min after ONI.
  
  
  CONCLUSIONS
  The Nrf2-ARE pathway was activated after ONI, providing evidence for the study of the protection and underlying mechanism of Nrf2-ARE pathway on optic nerves.
authors.affiliation: 1.Department of Ophthalmology, Jinling Hospital, Nanjing 210002, China 2.Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University,Nanjing 210002, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yan
authors.forename: Sui Hua
authors.initials: SH
authors.lastname: Chen
authors.forename: Xiang Jun
authors.initials: XJ
authors.lastname: Li
authors.forename: Chuang
authors.initials: C
authors.lastname: Nie
authors.forename: Hai Nan
authors.initials: HN
authors.lastname: Xie
mesh_terms: D000818:Animals; D008285:Major Histocompatibility Complex / Q000235:genetics; D051379:Mice; D050984:NF-E2 Transcription Factor, p45 Subunit / Q000235:genetics / Q000378:metabolism*; D009900:Optic Nerve / Q000378:metabolism*; D020221:Optic Nerve Injuries / Q000378:metabolism*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D015854:Up-Regulation; D033921:Vesicular Transport Proteins
chemical_list: D050984:NF-E2 Transcription Factor, p45 Subunit; C494693:Nfe2 protein, mouse; D011506:Proteins; D012333:RNA, Messenger; D033921:Vesicular Transport Proteins; C485462:Vps52 protein, mouse