title: Effect of Pinus massoniana Lamb. bark extract on lytic cycle of Epstein-Barr virus.
abstract: Pinus massoniana bark extract (PMBE) at a concentration of 60 microg/mL or more inhibits the expression of Epstein-Barr virus (EBV) lytic proteins, such as Rta, Zta, and EA-D. EBV lytic cycle was blocked by inhibiting the transcription of immediate-early genes. The results suggest that the PMBE has anti-EBV activity. Thus, the extract is potentially useful in preventing the lytic development of EBV in vitro.
authors.affiliation: College of Life Science, Henan Agriculture University, Zhenzhou, Henan, China.
authors.forename: Shuxia
authors.initials: S
authors.lastname: Xu
authors.forename: Shimin
authors.initials: S
authors.lastname: Zhang
authors.forename: Xuedong
authors.initials: X
authors.lastname: Wang
authors.forename: Yaqian
authors.initials: Y
authors.lastname: Gao
authors.forename: Xing
authors.initials: X
authors.lastname: Qin
authors.forename: Kun
authors.initials: K
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D002851:Chromatography, High Pressure Liquid; D020031:Epstein-Barr Virus Infections / Q000188:drug therapy / Q000378:metabolism / Q000821:virology*; D015967:Gene Expression Regulation, Viral / Q000187:drug effects; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics; D028223:Pinus / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017874:Immediate-Early Proteins; D010936:Plant Extracts; D014764:Viral Proteins