title: Imaging of skin microvessels with optical coherence tomography: potential uses in port wine stains.
abstract: The knowledge of vascular structures of port wine stains (PWSs) may be useful to select treatment doses and improve therapeutic efficacy. Biopsies are impractical to implement, therefore, it is necessary to develop non-invasive techniques for morphological evaluation. This study aimed to evaluate the application of a novel optical coherence tomography (OCT) system to characterize the vascular structures of PWSs. First, OCT images were obtained from the skin of healthy rabbit ears and compared with the histopathological images. Second, OCT was used to document the differences between PWS lesions and contralateral normal skin; the size and depth of the vascular structures of two clinical types of PWSs were measured and statistically analyzed. The dermal blood vessels of healthy rabbit ears were clearly distinguished from other tissue. There was no statistical difference between the vascular diameter or depth measured by OCT images and histopathological sections (P>0.05). The OCT images of the PWSs could be distinguished from normal skin. There was no statistical difference in the depth of vessels between the purple-type and the proliferative-type PWSs (P>0.05), while there was statistical difference in the diameter of vessels between them (P<0.01). Therefore, OCT is a promising, real-time, in vivo and non-invasive tool with which to characterize the vascular structures of PWSs.
authors.affiliation: The Department of Laser Medicine, The PLA General Hospital, Beijing 100853;
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.forename: Daiqiang
authors.initials: D
authors.lastname: Yin
authors.forename: Ping
authors.initials: P
authors.lastname: Xue
authors.forename: Naiyan
authors.initials: N
authors.lastname: Huang
authors.forename: Haixia
authors.initials: H
authors.lastname: Qiu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Ding
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu