title: Anti-inflammatory effect of fucoidan extracted from Ecklonia cava in zebrafish model.
abstract: Fucoidan extracted from Ecklonia cava had strong anti-inflammatory activities. However, the direct effects of fucoidan of E. cava on anti-inflammatory activities in vivo model remained to be determined. Therefore, the present study was designed to assess in vivo anti-inflammatory effect of fucoidan extracted from E. cava (ECF) using tail-cutting-induced and lipopolysaccharide (LPS)-stimulated zebrafish model. Treating zebrafish model with tail-cutting and LPS-treatment significantly increased the ROS and NO level. However, ECF inhibited this tail-cutting-induced and LPS-stimulated ROS and NO generation. These results show that ECF alleviated inflammation by inhibiting the ROS and NO generation induced by tail-cutting and LPS-treatment. In addition, ECF has a protective effect against the toxicity induced by LPS exposure in zebrafish embryos. This outcome could explain the potential anti-inflammatory activity of ECF, which might have a beneficial effect during the treatment of inflammatory diseases.
authors.affiliation: School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Seung-Hong
authors.initials: SH
authors.lastname: Lee
authors.forename: Chang-Ik
authors.initials: CI
authors.lastname: Ko
authors.forename: Youngheun
authors.initials: Y
authors.lastname: Jee
authors.forename: Yoonhwa
authors.initials: Y
authors.lastname: Jeong
authors.forename: Misook
authors.initials: M
authors.lastname: Kim
authors.forename: Jin-Soo
authors.initials: JS
authors.lastname: Kim
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology; D008070:Lipopolysaccharides / Q000633:toxicity; D009569:Nitric Oxide / Q000378:metabolism; D000459:Phaeophyceae / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology; D015027:Zebrafish / Q000276:immunology*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D011134:Polysaccharides; D009569:Nitric Oxide; C007789:fucoidan