title: Animal models for neonatal diseases in humans.
abstract: The development of vaccines for infants and young children requires the use of animal models at various stages of preclinical development. Animal models are being used to assess the quantity and quality of the immune response, onset and duration of the response, induction of systemic versus local immunity, protection against challenge infection for the assessment of vaccine efficacy, as well as safety and toxicity of the vaccine formulation itself. A variety of animal models are available, each with its own specific advantages and disadvantages. Here, we review the most common animal models for preclinical vaccine development for human infants.
authors.affiliation: Vaccine and Infectious Disease Organization-InterVac, University of Saskatchewan, Saskatoon, S7N5E3, Canada.
authors.forename: Benoît
authors.initials: B
authors.lastname: Levast
authors.forename: Sandra
authors.initials: S
authors.lastname: Schulz
authors.forename: Sylvia van Drunen Littel-van den
authors.initials: Sv
authors.lastname: Hurk
authors.forename: Volker
authors.initials: V
authors.lastname: Gerdts
mesh_terms: D000818:Animals; D002648:Child; D004195:Disease Models, Animal; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000276:immunology* / Q000517:prevention & control; D014612:Vaccines / Q000276:immunology* / Q000494:pharmacology
chemical_list: D014612:Vaccines