title: Impact of aging on the progression of neuropathy after liver transplantation in transthyretin Val30Met amyloidosis.
abstract: BACKGROUND
  Information related to the long-term follow-up of neuropathy in patients with familial amyloid polyneuropathy after liver transplantation is still scarce.
  
  
  METHODS
  We describe the neuropathic features of 3 patients with the transthyretin Val30Met mutation. Each patient underwent liver transplantation at an early stage of neuropathy, as indicated by the absence of motor dysfunction and relative preservation of myelinated fibers in sural nerve biopsy specimens.
  
  
  RESULTS
  Although the patient with late-onset disease (at age 60 years) presented with the least amount of amyloid deposition, he had neuropathic progression after liver transplantation. An older early-onset (at age 40 years) patient reported a slight exacerbation of both somatic and autonomic neuropathic symptoms 10 years after transplantation. However, the younger early-onset (at age 28 years) patient did not exhibit characteristics suggestive of neuropathy 7 years after transplantation.
  
  
  CONCLUSIONS
  Aging may determine the progression of neuropathy after liver transplantation.
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. koike-haruki@med.nagoya-u.ac.jp
authors.forename: Haruki
authors.initials: H
authors.lastname: Koike
authors.forename: Rina
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Minoru
authors.initials: M
authors.lastname: Tomita
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kawagashira
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iijima
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Nakamura
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Watanabe
authors.forename: Hideya
authors.initials: H
authors.lastname: Kamei
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kiuchi
authors.forename: Gen
authors.initials: G
authors.lastname: Sobue
mesh_terms: D000328:Adult; D000375:Aging; D028227:Amyloid Neuropathies, Familial / Q000209:etiology*; D006801:Humans; D008107:Liver Diseases / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D008137:Longitudinal Studies; D008297:Male; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D011228:Prealbumin / Q000235:genetics*; D014633:Valine / Q000235:genetics*
chemical_list: D011228:Prealbumin; D008715:Methionine; D014633:Valine