title: Synthesis and antimicrobial activity of some new  1,3,4-thiadiazole derivatives.
abstract: New series of 1,3,4-thiadiazoles have been prepared via reaction of  1,3,4-thiadiazolenaminones 1 with N-phenyl 2-oxopropanehydrazonoyl chloride (2) in dioxane in the presence of triethylamine. Also, some new heterocycles incorporating  1,3,4-thiadiazole ring were obtained by reaction of 1,3,4-thiadiazolenaminones 1 with nitrogen-nucleophiles like hydrazine hydrate, 3-amino-1,2,4-triazole and  2-aminobenzimidazole. The structure of the new products was established based on elemental and spectral analysis. The relation between the structure of the products and their activity towards some microorganisms was studied and promising results were obtained.
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
authors.forename: Thoraya A
authors.initials: TA
authors.lastname: Farghaly
authors.forename: Magda A
authors.initials: MA
authors.lastname: Abdallah
authors.forename: Mohamed R Abdel
authors.initials: MR
authors.lastname: Aziz
mesh_terms: D000640:Amitrole / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D013830:Thiadiazoles; C058949:1,3,4-thiadiazole; D000640:Amitrole