title: [A case of lymph node recurrence of endocrine cell carcinoma of stomach effectively treated with carboplatin and etoposide].
abstract: We report a patient with lymph node recurrent endocrine cell carcinoma of the stomach who responded remarkably to carboplatin and etoposide chemotherapy. A 67-year-old woman underwent total gastrectomy under the diagnosis of poorly differentiated gastric carcinoma with esophagus and lymph node invasion. Adjuvant chemotherapy was not conducted because of the delay of postoperative recovery despite III b staging. Recurrence in thoracic paratracheal lymph node was diagnosed 6 months after surgery by follow-up CT scan. Carboplatin and etoposide were administrated for 4 months(6 courses of treatment), and complete response was obtained after 3 courses of treatment. The absence of recurrence was confirmed for 6 months after treatment. Although grade 4 neutropenia, grade 3 nausea and grade 2 vomiting were observed in first course of treatment, supportive therapy with G-CSF and aprepitant were useful for the continuity of treatment. Carboplatin and etoposide therapy may be one of the better candidates for stomach endocrine cell carcinoma in terms of its effects and tolerability, compared with a chemotherapy regimen combined with cisplatin.
authors.affiliation: Dept. of Gastroenterological Surgery, Nagoya University, Japan.
authors.forename: Norifumi
authors.initials: N
authors.lastname: Ohashi
authors.forename: Satomi
authors.initials: S
authors.lastname: Jinno
authors.forename: Tomoya
authors.initials: T
authors.lastname: Shimokata
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kobayashi
authors.forename: Chie
authors.initials: C
authors.lastname: Tanaka
authors.forename: Michitaka
authors.initials: M
authors.lastname: Fujiwara
authors.forename: Suguru
authors.initials: S
authors.lastname: Yamada
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fujii
authors.forename: Shuji
authors.initials: S
authors.lastname: Nomoto
authors.forename: Shin
authors.initials: S
authors.lastname: Takeda
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kodera
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D005047:Etoposide; D016190:Carboplatin