title: Glucocerebrosidase L444P mutation confers genetic risk for Parkinson's disease in central China.
abstract: BACKGROUND
  Mutations of the glucocerebrosidase (GBA) gene have reportedly been associated with Parkinson disease (PD) in various ethnic populations such as Singaporean, Japanese, Formosan, Canadian, American, Portuguese, Greek, Brazilian, British, Italian, Ashkenazi Jewish, southern and southwestern Chinese. The purpose of this study is to determine in central China whether or not the reported GBA mutations remain associated with PD.
  
  
  METHODS
  In this project, we conducted a controlled study in a cohort of 208 central Chinese PD patients and 298 controls for three known GBA mutations (L444P, N370S and R120W).
  
  
  RESULTS
  Our data reveals a significantly higher frequency of L444P mutation in GBA gene of PD cases (3.4%) compared with the controls (0.3%) (P = 0.007, OR = 10.34, 95% CI = 1.26 - 84.71). Specifically, the frequency of L444P mutation was higher in the late onset PD (LOPD) cases compared with that in control subjects. The N370S and R120W mutations were detected in neither the PD group nor the control subjects.
  
  
  CONCLUSIONS
  Our observations demonstrated that the GBA L444P mutation confers genetic risk for PD, especially LOPD, among the population in the central China area.
authors.affiliation: Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, 430022, China.
authors.forename: Youpei
authors.initials: Y
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Xiong
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Chen
authors.forename: Lan
authors.initials: L
authors.lastname: Yu
authors.forename: Chunnuan
authors.initials: C
authors.lastname: Chen
authors.forename: Jinsha
authors.initials: J
authors.lastname: Huang
authors.forename: Zhentao
authors.initials: Z
authors.lastname: Zhang
authors.forename: Asrah A
authors.initials: AA
authors.lastname: Mohmed
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Lin
authors.forename: Nian
authors.initials: N
authors.lastname: Xiong
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005962:Glucosylceramidase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics*
chemical_list: D005962:Glucosylceramidase