title: [Pathogenetic bases of epileptogenesis in cerebral cavernomas].
abstract: INTRODUCTION. Brain cavernoma are a type of arteriovenous malformation that clinically presenting seizures, neurological deficit or bleeding. Hypoxia, neoangiogenesis and metalloproteasas seems to be involved in seizures physiopathology. Our study aims to assess this potential relation by immunohistochemical methods, analyzing hypoxia inducible factor (HIF-1alpha) and metalloproteasa (MMP-9) in tissue surrounding cavernoma. PATIENTS AND METHODS. We selected 17 consecutive cases anatomopathologically diagnosed as cavernoma during 9 years. Immunohistochemical staining was performed for HIF-1alpha and MMP-9. We evaluated the relation between seizures and the scale of uptake of different tissues surrounding cavernoma. RESULTS. Cases with seizures had HIF-1alpha positive uptake in vascular endothelium in 31%, 17% in fibrous tissue and 34% in inflammatory tissue. Besides, it also shows MMP-9 positive uptake in vascular endothelium in 86%, 100% in fibrous tissue and 43% of brain tissue. Statistical analysis by chi-square and odds ratio shows a positive trend towards seizures and the presence of HIF-1alpha and MMP-9 in vascular tissue, fibrous tissue and brain tissue, but no for inflammatory tissue. CONCLUSION. HIF-1alpha and MMP-9, valued by immunohistochemical methods, are related to complications as seizures.
authors.affiliation: Hospital Universitario Central de Asturias, Oviedo, Espana. arraitz@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Alvarez de Eulate-Beramendi
authors.forename: M A
authors.initials: MA
authors.lastname: Alvarez-Vega
authors.forename: A
authors.initials: A
authors.lastname: Antuna-Ramos
authors.forename: K
authors.initials: K
authors.lastname: Pina-Batista
authors.forename: J M
authors.initials: JM
authors.lastname: Jimenez-Duarte
authors.forename: J
authors.initials: J
authors.lastname: Gutierrez-Morales
authors.forename: A
authors.initials: A
authors.lastname: Astudillo-Gonzalez
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000150:complications*; D002675:Child, Preschool; D004730:Endothelium, Vascular / Q000737:chemistry; D005260:Female; D006392:Hemangioma, Cavernous / Q000150:complications*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000032:analysis; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis; D012640:Seizures / Q000209:etiology*
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D020780:Matrix Metalloproteinase 9