title: [GynOphilus--a winning relay].
abstract: The vagina is a complex biocenosis where many micro-organisms coexist and colonize it. The dominant colonizing bacteria of a healthy individual is of the genus "lactobacillus". It is also called Doderlein's bacillus and determines the vaginal microbial balance through the production of lactic acid, hydrogen peroxide, biosurfactants, bacteriocines and modify the competition of pathogens for adhesion to the vaginal epithelial cells. Through these mechanisms the lactobacilli block the growth and development of other vaginal pathogenic microbial species and also inhibit the colonization of some other microorganisms imported from outside. Because of these potential therapeutic properties, the lactobacilli are used as effective medical agents for prophylaxys and therapy to restore the physiological balance in the vaginal eco-system. According to our studies and gained clinical experience the etiological antibacterial treatment is not always sufficient to restore the normal vaginal flora. The complete recovery of the vaginal flora could be reached using probiotics that are applied locally and per os. GynOphilus is a new vaginal probiotic product containing one type of the genus "Lactobacillus": Lactobacillus casei var rhamnosus. GynOphilus restores the physiological balance of the vaginal flora and reduces the risk of recurrent infection. The product is applied intravaginal and interacts locally, inhibits the growth of the most common vaginal pathogens: Gardnerella vaginalis u Candida albicans.
authors.forename: S
authors.initials: S
authors.lastname: Kovachev
mesh_terms: D002176:Candida albicans / Q000254:growth & development; D002177:Candidiasis / Q000517:prevention & control*; D005260:Female; D006194:Gardnerella vaginalis / Q000254:growth & development; D006801:Humans; D052201:Lacticaseibacillus rhamnosus / Q000502:physiology*; D019936:Probiotics / Q000008:administration & dosage / Q000627:therapeutic use*; D014621:Vagina / Q000382:microbiology*; D016585:Vaginosis, Bacterial / Q000517:prevention & control*