title: An electrochemical nickel-catalyzed arylation of 3-amino-6-chloropyridazines.
abstract: 3-Amino-6-aryl- and 3-amino-6-heteroarylpyridazines have been obtained in generally good yield using a nickel-catalyzed electrochemical cross-coupling between 3-amino-6-chloropyridazines and aryl or heteroaryl halides at room temperature. Comparative experiments involving classical palladium-catalyzed reactions, such as Suzuki, Stille, or Negishi cross-couplings, reveal that the electrochemical method can constitute a reliable alternative tool for biaryl formation. A possible reaction mechanism is proposed on the basis of electrochemical analyses.
authors.affiliation: Equipe Electrochimie et Synthèse Organique, Institut de Chimie et des Matériaux Paris-Est, UMR 7182 CNRS-Université Paris-Est Créteil Val de Marne, 2 rue Henri Dunant, BP 28, F-94320, Thiais, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Sengmany
authors.forename: Arnaud
authors.initials: A
authors.lastname: Vitu-Thiebaud
authors.forename: Erwan
authors.initials: E
authors.lastname: Le Gall
authors.forename: Sylvie
authors.initials: S
authors.lastname: Condon
authors.forename: Eric
authors.initials: E
authors.lastname: Léonel
authors.forename: Christine
authors.initials: C
authors.lastname: Thobie-Gautier
authors.forename: Muriel
authors.initials: M
authors.lastname: Pipelier
authors.forename: Jacques
authors.initials: J
authors.lastname: Lebreton
authors.forename: Didier
authors.initials: D
authors.lastname: Dubreuil
mesh_terms: D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry*; D055664:Electrochemical Techniques; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D003432:Cross-Linking Reagents; D011724:Pyridazines; D009532:Nickel