title: A bis(triazole)benzamide receptor for the complexation of halide anions and neutral carboxylic acid guests. Guest-controlled topicity and self-assembly.
abstract: Bis(triazole)benzamide 1 has been readily synthesized by means of Cu-catalyzed 1,3-dipolar cycloaddition and its ability to bind halide anions and neutral gallic acid derivative 12GA has been theoretically and experimentally investigated. The cavity defined by the N-H amide group and the vicinal aromatic hydrogens is suitable to form H-bonding arrays with halide guests. The stability of complexes 1·Cl(-) and 1·Br(-) is very similar, as DFT calculations predict and (1)H NMR titration experiments confirm. The zigzag "anti" conformation of the molecule generates two regions with complementary positive and negative potentials that favor the statistical complexation of two molecules of the neutral carboxylic acid 12GA. This guest-controlled topicity demonstrates the versatility of this class of receptor to bind species of different nature. The amide group determines the complexation of both anionic and neutral species by primary acid-base interactions.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias Químicas, Ciudad Universitaria s/n, 28040 Madrid, Spain.
authors.forename: Fátima
authors.initials: F
authors.lastname: García
authors.forename: Juan
authors.initials: J
authors.lastname: Aragó
authors.forename: Rafael
authors.initials: R
authors.lastname: Viruela
authors.forename: Enrique
authors.initials: E
authors.lastname: Ortí
authors.forename: Luis
authors.initials: L
authors.lastname: Sánchez
mesh_terms: D000838:Anions / Q000737:chemistry; D001549:Benzamides / Q000737:chemistry*; D001966:Bromine / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002713:Chlorine / Q000737:chemistry*; D008958:Models, Molecular; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000838:Anions; D001549:Benzamides; D002264:Carboxylic Acids; D014230:Triazoles; D002713:Chlorine; C037689:benzamide; D001966:Bromine