title: Controllable and reproducible construction of a SERS substrate and its sensing applications.
abstract: A simple method for the preparation of a highly stable and reliable surface-enhanced Raman scattering (SERS) substrate was proposed. The SERS enhancement was demonstrated with good controllability and reproducibility through the controlled formation/deformation of SERS "hotspots" using a reversible DNA nanoswitch. Highly effective DNA detection was achieved using a well-designed sandwich structure.
authors.affiliation: Research Center for Bioengineering & Sensing Technology, University of Science and Technology Beijing, Beijing 100083, China. wyq_wen@ustb.edu.cn
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Wen
authors.forename: Wenqian
authors.initials: W
authors.lastname: Wang
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Liping
authors.initials: L
authors.lastname: Xu
authors.forename: Hongwu
authors.initials: H
authors.lastname: Du
authors.forename: Xueji
authors.initials: X
authors.lastname: Zhang
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Song
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009841:Oligonucleotides / Q000235:genetics; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013499:Surface Properties
chemical_list: D004220:Disulfides; D008024:Ligands; D009841:Oligonucleotides; D012834:Silver; D000255:Adenosine Triphosphate; D004247:DNA