title: Evolution of gene regulation: hybrid networks breed diversity.
abstract: How do gene regulatory networks evolve? A new study in yeasts shows that cis- and trans-regulatory changes resulted in a hybrid state of coexisting ancestral and derived regulatory circuits. This hybrid state then diversified into a variety of modern networks.
authors.affiliation: Department of Cell and Developmental Biology and Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Andrea I
authors.initials: AI
authors.lastname: Ramos
authors.forename: Scott
authors.initials: S
authors.lastname: Barolo
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D053263:Gene Regulatory Networks; D015003:Yeasts / Q000235:genetics*