title: A new chlorinated diphenyl ether and five known polyketide metabolites from Penicillium griseofulvum cib-119.
abstract: A series of polyketide metabolites (1-6), including a new chlorinated diphenyl ether (4-chloro-7,4'-dihydroxy-5,2'-dimethoxy-2-methylformate-6'-methybenzophone, 1), were isolated from the solid-fermented rice culture of Penicillium griseofulvum cib-119. The structure of compound 1 was determined on the basis of NMR spectra and single-crystal X-ray diffraction analyses. In addition, compound 1 showed weak cytotoxic activity against prostatic carcinoma cell (PC-3). Compounds 3-5 exhibited significant antimicrobial activities against Staphylococcus aureus and Bacillus subtilis.
authors.affiliation: Ethnic Pharmaceutical Institute of College of Southwest University for Nationalities, Chengdu, 610041, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhan
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Han
authors.forename: Guo-You
authors.initials: GY
authors.lastname: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008297:Male; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D010647:Phenyl Ethers / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D010647:Phenyl Ethers; C031538:phenyl ether