title: Cellular alchemy and the golden age of reprogramming.
abstract: The 2012 Nobel Prize in Medicine or Physiology recognizes the architects of two of the great paradigm-shifting discoveries of the last half-century of biology. In experiments performed nearly 50 years apart, Gurdon and Yamanaka made feasible the reawakening of pluripotency inherent in all cells and challenged forever our notions of cellular identity.
authors.affiliation: Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA. george.daley@childrens.harvard.edu
authors.forename: George Q
authors.initials: GQ
authors.lastname: Daley
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007564:Japan; D009613:Nobel Prize; D010827:Physiology / Q000266:history*; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D057905:Stem Cell Research; D006113:United Kingdom