title: Determination sulfamethoxazole based chemiluminescence and chitosan/graphene oxide-molecularly imprinted polymers.
abstract: A novel flow injection chemiluminescence (FI-CL) sensor for the determination of sulfamethoxazole (SMZ) was established which using chitosan/graphene oxide-molecularly imprinted polymers (CG-MIP) as recognition element. The SMZ-CG-MIP was synthesized in acetone as solvent and chitosan/graphene oxide for support, using acrylamide as functional monomer, ethylene glycol dimethacrylate as cross-linker and 2,2-azobisisobutyronitrile as initiator. The CG-MIP showed satisfactory recognition capacity for the SMZ. Then the synthesized CG-MIP was employed as recognition by packing into a lab-made tube connected in FI-CL analyzer to establish a novel CL sensor respectively. The CL intensity responded linearly to the concentration of SMZ in the range 1.0 × 10(-7)mol/L to 2.3 × 10(-3)mol/L with a detection limit of 2.9 × 10(-8)mol/L (3σ), which is lower. The relative standard deviation for the determination of 4.0 × 10(-4)mol/L of SMZ was 1.92% (n=11). The sensor is reusable and has a great improvement in sensitivity and selectivity for CL analysis which applied to the determination of SMZ in drug samples.
authors.affiliation: School of Chemistry and Chemical Engineering, University of Jinan, No. 106, Jiwei Road, Jinan 250022, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Huamin
authors.forename: Fan
authors.initials: F
authors.lastname: Lulu
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Li
authors.forename: Leilei
authors.initials: L
authors.lastname: Li
authors.forename: Sun
authors.initials: S
authors.lastname: Min
authors.forename: Luo
authors.initials: L
authors.lastname: Chuannan
mesh_terms: D015374:Biosensing Techniques; D048271:Chitosan / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D057230:Limit of Detection; D049449:Luminescence; D054802:Molecular Imprinting; D010087:Oxides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013420:Sulfamethoxazole / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D010087:Oxides; D011108:Polymers; D006108:Graphite; D048271:Chitosan; D013420:Sulfamethoxazole