title: [Peculiarities of age changes of NF200(+)-neurons in the sensory ganglia of different segmental levels after chemical deafferentation].
abstract: Morphological features of the neurons containing neurofilaments with molecular mass of 200 kD (NF200+), were studied in the sensory ganglia of thoracic and lumbar spinal nerves in rats (n = 80) during the first year of their life. Capsaicin treatment (150 mg/kg) of the newborn animals resulted in the change of age dynamics of NF200+ neurons. This was reflected by a reduction of NF200+ neuron numbers and their cross-sectional areas in both ganglia. Segmental differences included greater reduction of NF200+ neuron number in the sensory ganglion of lumbar spinal nerve in both early and late developmental periods.
authors.forename: V V
authors.initials: VV
authors.lastname: Porseva
authors.forename: V V
authors.initials: VV
authors.lastname: Shilkin
authors.forename: M B
authors.initials: MB
authors.lastname: Korzina
authors.forename: V P
authors.initials: VP
authors.lastname: Smirnova
authors.forename: P M
authors.initials: PM
authors.lastname: Masliukov
mesh_terms: D000375:Aging / Q000187:drug effects / Q000473:pathology*; D000818:Animals; D002211:Capsaicin / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D005727:Ganglia, Spinal / Q000378:metabolism / Q000473:pathology; D016900:Neurofilament Proteins / Q000378:metabolism*; D009475:Neurons, Afferent / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D018689:Sensory System Agents / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D016900:Neurofilament Proteins; D018689:Sensory System Agents; C051774:neurofilament protein H; D002211:Capsaicin