title: High 99mTc-DPD myocardial uptake in a patient with apolipoprotein AI-related amyloidotic cardiomyopathy.
abstract: Amyloidotic cardiomyopathy is still a widely underdiagnosed condition that usually requires endomyocardial biopsy (EMB) for a definite diagnosis. 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) has proven highly sensitive for detecting amyloidotic cardiomyopathy due to transthyretin-related amyloid deposition. Herein we report the first description of the (99mTc-DPD scintigraphy profile in a patient with suspected amyloidotic cardiomyopathy and a final EMB- and genetically-proven diagnosis of familial apolipoprotein AI amyloidosis due to Leu174Ser variant.
authors.affiliation: Institute of Cardiology, University of Bologna and S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Candida Cristina
authors.initials: CC
authors.lastname: Quarta
authors.forename: Laura
authors.initials: L
authors.lastname: Obici
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Guidalotti
authors.forename: Maurizio
authors.initials: M
authors.lastname: Pieroni
authors.forename: Simone
authors.initials: S
authors.lastname: Longhi
authors.forename: Stefano
authors.initials: S
authors.lastname: Perlini
authors.forename: Laura
authors.initials: L
authors.lastname: Verga
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Merlini
authors.forename: Claudio
authors.initials: C
authors.lastname: Rapezzi
mesh_terms: D028227:Amyloid Neuropathies, Familial / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000378:metabolism*; D016632:Apolipoprotein A-I / Q000235:genetics*; D009202:Cardiomyopathies / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000378:metabolism*; D004164:Diphosphonates / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D015609:Organotechnetium Compounds / Q000378:metabolism*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000378:metabolism*
chemical_list: D016632:Apolipoprotein A-I; D004164:Diphosphonates; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C033905:technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid