title: Interaction between titanium and cadmium in various guinea pig organs.
abstract: Titanium (Ti) is used in many fields, while cadmium (Cd) is known to cause the itai-itai disease. In the present study, possible interactions between titanium and cadmium were investigated. Aorta, taenia coli, and liver were removed from male guinea pigs. Muscle tension was measured using intact aorta and taenia coli and using β-escin-permeabilized taenia coli in a physiological salt solution and a hyperpotassium solution containing Cd and/or Ti. Cellular Cd contents were determined using all tissues after washout with EDTA solution. Cadmium-induced relaxation in the hyperpotassium solution recovered significantly (P < 0.01) following Ti treatment in taenia coli, but not in the aorta. In β-escin-permeabilized taenia coli, the percentage recoveries after Cd treatment and after Ti plus Cd treatment were 67.3 ± 8.7 % (n = 4) and 87.7 ± 3.8 % (n = 4), respectively, compared with Ca-induced control contraction. Cellular Cd contents in taenia coli decreased significantly following treatment with Ti 10(-4) M. Although similar results were obtained using the aorta and the liver, there were no significant differences between the control and Ti 10(-5) M. High concentrations of Ti may reduce cellular Cd content.
authors.affiliation: Laboratory of Veterinary Public Health, School of Veterinary Medicine, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Takano
authors.forename: Takeharu
authors.initials: T
authors.lastname: Kaneda
authors.forename: Masaki
authors.initials: M
authors.lastname: Kaneshige
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tsutsumi
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Ochiai
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Shimizu
authors.forename: Ryo
authors.initials: R
authors.lastname: Hondo
authors.forename: Mariko
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Fukiko
authors.initials: F
authors.lastname: Ueda
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D002104:Cadmium / Q000378:metabolism* / Q000494:pharmacology; D002463:Cell Membrane Permeability; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D004928:Escin / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009129:Muscle Tonus; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D012996:Solutions / Q000378:metabolism; D013054:Spectrophotometry, Atomic; D014025:Titanium / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D012996:Solutions; D002104:Cadmium; D004928:Escin; D014025:Titanium; D011188:Potassium