title: Kadcoccitones A and B, two new 6/6/5/5-fused tetracyclic triterpenoids from Kadsura coccinea.
abstract: A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C(9) side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC(50) value of 47.91 and 32.66 μg/mL, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Cheng-Qin
authors.initials: CQ
authors.lastname: Liang
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shi
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Luo
authors.forename: Xing-Yao
authors.initials: XY
authors.lastname: Li
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Gao
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Shan-Zhai
authors.initials: SZ
authors.lastname: Shang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Zhang
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D032135:Kadsura / Q000737:chemistry*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C578923:kadcoccitone A; C578924:kadcoccitone B