title: Increased level of platelet P-selectin in nonarteritic anterior ischemic optic neuropathy.
abstract: OBJECTIVE
  P-selectin receptor is expressed in platelets and endothelial cells in a cell-activation-dependent manner. Platelet P-selectin (CD62) levels may become elevated in a number of vasoocclusive diseases, including arteriosclerosis, atherothrombosis, and diabetes mellitus (DM). Nonarteritic anterior ischemic optic neuropathy (NAION) is associated with a sudden loss of vision due to the vascular insufficiency of ciliary arteries supplying the optic nerve. In this study, our aim was to investigate the presence of increased platelet reactivity in the development of NAION.
  
  
  METHODS
  Twenty-one NAION patients, 39 healthy control subjects, and 44 patients suffering from diabetes mellitus (DM) were examined in our case-control, pilot study. Platelet activation was investigated by flow cytometric analysis of the mean fluorescence intensity (MFI) of CD62 on platelets. These results were compared among the different study groups.
  
  
  RESULTS
  NAION patients showed considerably although not significantly (p = 0.2017) higher P-selectin MFI values (71.98 ± 40.30) versus healthy subjects (55.48 ± 20.95), insulin-dependent DM patients (50.02 ± 13.08), and non-insulin-dependent DM subjects (54.72 ± 24.74). However, logistic regression analysis resulted in a statistically significant adjusted effect on the odds of NAION when CD62 MFI values were logarithmically transformed (OR: 3.86, 95 % CI: 1.10 to 13.53, p = 0.0346).
  
  
  CONCLUSIONS
  Elevated platelet CD62 positivity may be related to NAION, suggesting a possible role of enlarged platelet activity in the generation of this type of ischemic optic neuropathy.
authors.affiliation: Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, 4012 Debrecen, Hungary. vnagy@med.unideb.hu
authors.forename: Valeria
authors.initials: V
authors.lastname: Nagy
authors.forename: Bence
authors.initials: B
authors.lastname: Kolozsvari
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Balogh
authors.forename: Adrienne
authors.initials: A
authors.lastname: Csutak
authors.forename: Marta
authors.initials: M
authors.lastname: Kasza
authors.forename: Bela
authors.initials: B
authors.lastname: Nagy
authors.forename: Laszlo
authors.initials: L
authors.lastname: Kardos
authors.forename: Andras
authors.initials: A
authors.lastname: Berta
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Pfliegler
mesh_terms: D000368:Aged; D001167:Arteritis / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D018917:Optic Neuropathy, Ischemic / Q000097:blood*; D019007:P-Selectin / Q000097:blood*; D010865:Pilot Projects; D015539:Platelet Activation; D012307:Risk Factors; D014792:Visual Acuity / Q000502:physiology
chemical_list: D019007:P-Selectin