title: One-stage hepatectomy following portal vein embolization for colorectal liver metastasis.
abstract: BACKGROUND
  Although portal vein embolization (PVE) has been applied for surgical resection of colorectal liver metastases (CLM), the clinical usefulness of liver surgery following PVE for CLM remains unknown.
  
  
  METHODS
  A total of 115 patients were evaluated retrospectively. Among them, 49 underwent one-stage hepatectomy following PVE (PVE group). The remaining 66 patients underwent at least hemihepatectomy without PVE (non-PVE group). This analysis compared the short- and long-term outcomes between the PVE and non-PVE groups.
  
  
  RESULTS
  There were no deaths in either group. Using the Clavien-Dindo classification, the rates of postoperative morbidity ≥ grade 1 were 34.7% in the PVE group and 25.0% in the non-PVE group (p = 0.26). The 3-year overall survival rates were 54.6 and 64.5% in the PVE and non-PVE groups, respectively (p = 0.89). The multivariate analysis the variable performance/nonperformance of PVE was not detected as an independent predictor of poor survival.
  
  
  CONCLUSIONS
  Our one-stage hepatectomy policy of using PVE provides acceptable morbidity and favorable long-term outcomes.
authors.affiliation: Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Suguru
authors.initials: S
authors.lastname: Yamashita
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Michiro
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Inoue
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Taku
authors.initials: T
authors.lastname: Aoki
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kokudo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011169:Portal Vein; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome