title: The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran.
abstract: Background. The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran. Materials and Methods. A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied. No patients had positive family history of cancers. The frequencies of MSI were analyzed by testing the BAT-26 and BAT-25 markers. Results. MSI analysis revealed that 22.9% of the tumors (22 patients) were microsatellite instability positive and 77.1% (74 patients) were microsatellite instability negative. The highest rate of MSI (40.9%) was found in the rectal region. MSI-H status was seen more frequently in distal tumors (P = 0.04, odds ratio = 3.13, 0.96-10.14). Conclusions. Distal tumor location and MSI may associate with special clinicopathological features. It seems that there may be correlation with underlying genetic and immunologic mechanisms.
authors.affiliation: Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Faghani
authors.forename: Saba
authors.initials: S
authors.lastname: Fakhrieh Asl
authors.forename: Fariborz
authors.initials: F
authors.lastname: Mansour-Ghanaei
authors.forename: Keyvan
authors.initials: K
authors.lastname: Aminian
authors.forename: Alireza
authors.initials: A
authors.lastname: Tarang
authors.forename: Ramin
authors.initials: R
authors.lastname: Seighalani
authors.forename: Azadeh
authors.initials: A
authors.lastname: Javadi