title: Overlapping of primary biliary cirrhosis and small duct primary sclerosing cholangitis: first case report.
abstract: Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are both autoimmune cholestatic liver disease and the association of these two conditions in the same patient is very rare. We report the case of a female patient presenting with a cholestatic liver disease and a panel of autoantibodies specific for PBC, including antibodies to mitochondrial E2-pyruvate dehydrogenase, gp-210 and Sp-100. Beside these findings, the liver biopsy revealed concentric fibrosis of small biliary ducts and the magnetic resonance cholangiography presented no abnormal findings. Diagnosis of small duct PSC/PBC overlapping was done. No description of this association was found in the literature. Clinical and serological features of this unusual finding are discussed.
authors.affiliation: Division of Gastroenterology, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Elze Maria Gomes
authors.initials: EM
authors.lastname: Oliveira
authors.forename: Patricia Marinho
authors.initials: PM
authors.lastname: Oliveira
authors.forename: Vitoria
authors.initials: V
authors.lastname: Becker
authors.forename: Alessandra
authors.initials: A
authors.lastname: Dellavance
authors.forename: Luis Eduardo Coelho
authors.initials: LE
authors.lastname: Andrade
authors.forename: Valeria
authors.initials: V
authors.lastname: Lanzoni
authors.forename: Antonio Eduardo Benedito
authors.initials: AE
authors.lastname: Silva
authors.forename: Maria Lucia Gomes
authors.initials: ML
authors.lastname: Ferraz