title: Determination of trace and heavy metals in some commonly used medicinal herbs in Ayurveda.
abstract: Traditionally, the herbal drugs are well established for their therapeutic benefits. Depending upon their geographical sources sometimes the trace and heavy metals' content may differ, which may lead to severe toxicity. So, the toxicological and safety assessment of these herbal drugs are one of the major issues in recent days. Eight different plant species including Aloe vera, Centella asiatica, Calendula officinalis, Cucumis sativus, Camellia sinensis, Clitoria ternatea, Piper betel and Tagetes erecta were selected to determine their heavy and trace metals content and thereby to assure their safer therapeutic application. The trace and heavy metals were detected through atomic absorption spectrometry analysis. The selected medicinal plant materials were collected from the local cultivated regions of West Bengal, India, and were digested with nitric acid and hydrochloric acid as specified. Absorbance was measured through atomic absorption spectrometer (AA 303) and the concentration of different trace and heavy metals in the plant samples were calculated. The quantitative determinations were carried out using standard calibration curve obtained by the standard solutions of different metals. The contents of heavy metals were found to be within the prescribed limit. Other trace metals were found to be present in significant amount. Thus, on the basis of experimental outcome, it can be concluded that the plant materials collected from the specific region are safe and may not produce any harmful effect of metal toxicity during their therapeutic application. The investigated medicinal plants contain trace metals such as copper (Cu), chromium (Cr), manganese (Mn), iron (Fe) and nickel (Ni) as well as heavy metals such as arsenic (As), lead (Pb) and mercury (Hg), which were present within the permissible limit.
authors.affiliation: Department of Pharmaceutical Technology, School of Natural Product Studies, Jadavpur University, Kolkata, India.
authors.forename: Neelesh K
authors.initials: NK
authors.lastname: Nema
authors.affiliation: Department of Pharmaceutical Technology, School of Natural Product Studies, Jadavpur University, Kolkata, India.
authors.forename: Niladri
authors.initials: N
authors.lastname: Maity
authors.affiliation: Parker Robinson (P) Ltd, Kolkata, India.
authors.forename: Birendra K
authors.initials: BK
authors.lastname: Sarkar
authors.affiliation: Department of Pharmaceutical Technology, School of Natural Product Studies, Jadavpur University, Kolkata, India naturalproductm@gmail.com.
authors.forename: Pulok K
authors.initials: PK
authors.lastname: Mukherjee
mesh_terms: D007194:India; D008515:Medicine, Ayurvedic; D019216:Metals, Heavy / Q000032:analysis* / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013054:Spectrophotometry, Atomic
chemical_list: D019216:Metals, Heavy