title: [Correlation between CTLA-4 gene polymorphism and systemic lupus erythematosus: a meta-analysis].
abstract: OBJECTIVE
  To determine the correlation between CTLA-4 gene polymorphism and systemic lupus erythematosus (SLE) susceptibility.
  
  
  METHODS
  We collected all the publications about the relationship between CTLA-4 gene polymorphism and SLE susceptibility by searching PubMed,  Web of Knowledge,  Embase,  Wanfang,  CNKI and CBM before the date of May 20,  2012. The data were analyzed by the method of meta-analysis.
  
  
  RESULTS
  A total of 12 studies were included,  involving 3 gene locus,  -1722,  -1661 and -318. The results of total populations showed that there was a significant association between gene polymorphism and SLE risk in -1722 gene locus under a dominant model (OR=2.570,  95%CI=1.845-3.581,  P<0.01) and -318 gene locus under a recessive model (OR=0.044,  95%CI=0.020-0.094,  P<0.01). When stratified by population,  the association still existed in Asian population,  but no significant correlation existed in the other two populations (European and African).
  
  
  CONCLUSIONS
  This meta-analysis supports that the CTLA-4 1722T/C and -318T/C polymorphisms are associated with SLE susceptibility,  especially in Asian population.
authors.affiliation: Department of Epidemiology,  School of Public Health,  Key Laboratory of Public Health Safety,  Ministry of Education,  Fudan University,  Shanghai 200032,  China.
authors.forename: Shui-lian
authors.initials: SL
authors.lastname: Chen
authors.forename: Fei
authors.initials: F
authors.lastname: Deng
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.forename: Jia-jing
authors.initials: JJ
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Meng
mesh_terms: D060908:CTLA-4 Antigen / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D011110:Polymorphism, Genetic; D044469:Racial Groups / Q000235:genetics
chemical_list: D060908:CTLA-4 Antigen