title: Periodontitis is related to lung volumes and airflow limitation: a cross-sectional study.
abstract: This study aimed to assess the potential association of periodontal diseases with lung volumes and airflow limitation in a general adult population. Based on a representative population sample of the Study of Health in Pomerania (SHIP), 1463 subjects aged 25-86 years were included. Periodontal status was assessed by clinical attachment loss (CAL), probing depth and number of missing teeth. Lung function was measured using spirometry, body plethysmography and diffusing capacity of the lung for carbon monoxide. Linear regression models using fractional polynomials were used to assess associations between periodontal disease and lung function. Fibrinogen and high-sensitivity C-reactive protein (hs-CRP) were evaluated as potential intermediate factors. After full adjustment for potential confounders mean CAL was significantly associated with variables of mobile dynamic and static lung volumes, airflow limitation and hyperinflation (p<0.05). Including fibrinogen and hs-CRP did not change coefficients of mean CAL; associations remained statistically significant. Mean CAL was not associated with total lung capacity and diffusing capacity of the lung for carbon monoxide. Associations were confirmed for mean probing depth, extent measures of CAL/probing depth and number of missing teeth. Periodontal disease was significantly associated with reduced lung volumes and airflow limitation in this general adult population sample. Systemic inflammation did not provide a mechanism linking both diseases.
authors.affiliation: Dept of Restorative Dentistry, Periodontology and Endodontology, University of Medicine, Ernst-Moritz-Arndt University Greifswald, Greifswald.
authors.forename: Birte
authors.initials: B
authors.lastname: Holtfreter
authors.forename: Stefanie
authors.initials: S
authors.lastname: Richter
authors.forename: Thomas
authors.initials: T
authors.lastname: Kocher
authors.forename: Marcus
authors.initials: M
authors.lastname: Dörr
authors.forename: Henry
authors.initials: H
authors.lastname: Völzke
authors.forename: Till
authors.initials: T
authors.lastname: Ittermann
authors.forename: Anne
authors.initials: A
authors.lastname: Obst
authors.forename: Christoph
authors.initials: C
authors.lastname: Schäper
authors.forename: Ulrich
authors.initials: U
authors.lastname: John
authors.forename: Peter
authors.initials: P
authors.lastname: Meisel
authors.forename: Anne
authors.initials: A
authors.lastname: Grotevendt
authors.forename: Stephan B
authors.initials: SB
authors.lastname: Felix
authors.forename: Ralf
authors.initials: R
authors.lastname: Ewert
authors.forename: Sven
authors.initials: S
authors.lastname: Gläser
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D002248:Carbon Monoxide / Q000032:analysis / Q000737:chemistry; D003430:Cross-Sectional Studies; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D016014:Linear Models; D008168:Lung / Q000503:physiopathology; D008171:Lung Diseases / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications / Q000503:physiopathology*; D010991:Plethysmography; D011446:Prospective Studies; D012119:Respiration; D012129:Respiratory Function Tests; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D013147:Spirometry
chemical_list: D002248:Carbon Monoxide; D005340:Fibrinogen; D002097:C-Reactive Protein