title: Risk factors for gastric cancer in Latin America: a meta-analysis.
abstract: BACKGROUND
  Latin America has among the highest gastric cancer incidence rates in the world, for reasons that are still unknown. In order to identify region-specific risk factors for gastric cancer, we conducted a meta-analysis summarizing published literature.
  
  
  METHODS
  Searches of PubMed and regional databases for relevant studies published up to December 2011 yielded a total of 29 independent case-control studies. We calculated summary odds ratios (OR) for risk factors reported in at least five studies, including socioeconomic status (education), lifestyle habits (smoking and alcohol use), dietary factors (consumption of fruits, total vegetables, green vegetables, chili pepper, total meat, processed meat, red meat, fish, and salt), and host genetic variants (IL1B-511T, IL1B-31C, IL1RN*2, TNFA-308A, TP53 codon 72 Arg, and GSTM1 null). Study-specific ORs were extracted and summarized using random-effects models.
  
  
  RESULTS
  Chili pepper was the only region-specific factor reported in at least five studies. Consistent with multifactorial pathogenesis, smoking, alcohol use, high consumption of red meat or processed meat, excessive salt intake, and carriage of IL1RN*2 were each associated with a moderate increase in gastric cancer risk. Conversely, higher levels of education, fruit consumption, and total vegetable consumption were each associated with a moderately decreased risk. The other exposures were not significantly associated. No prospective study data were identified.
  
  
  CONCLUSIONS
  Risk factor associations for gastric cancer in Latin America are based on case-control comparisons that have uncertain reliability, particularly with regard to diet; the specific factors identified and their magnitudes of association are largely similar to those globally recognized. Future studies should emphasize prospective data collection and focus on region-specific exposures that may explain high gastric cancer risk.
authors.affiliation: Programa de Residencia en Epidemiología, Dirección General Adjunta de Epidemiología, Secretaría de Salud, Mexico City, Mexico.
authors.forename: Patricia
authors.initials: P
authors.lastname: Bonequi
authors.forename: Fernando
authors.initials: F
authors.lastname: Meneses-González
authors.forename: Pelayo
authors.initials: P
authors.lastname: Correa
authors.forename: Charles S
authors.initials: CS
authors.lastname: Rabkin
authors.forename: M Constanza
authors.initials: MC
authors.lastname: Camargo
mesh_terms: D004032:Diet; D005247:Feeding Behavior; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D008019:Life Style; D016017:Odds Ratio; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000209:etiology