title: Rare acute kidney injury secondary to hypothyroidism-induced rhabdomyolysis.
abstract: OBJECTIVE
  Acute kidney injury (AKI) caused by hypothyroidism-induced rhabdomyolysis is a rare and potentially life-threatening syndrome. The aim of this study was to investigate the clinical characteristics of such patients.
  
  
  METHODS
  We retrospectively analyzed five patients treated at the Second Affiliated Hospital of Chongqing Medical University with AKI secondary to hypothyroidism- induced rhabdomyolysis from January 2006 to December 2010.
  
  
  RESULTS
  Of the five cases reviewed (4 males, age range of 37 to 62 years), adult primary hypothyroidism was caused by amiodarone (1 case), chronic autoimmune thyroiditis (1 case), and by uncertain etiologies (3 cases). All patients presented with facial and lower extremity edema. Three patients presented with weakness, while two presented with blunted facies and oliguria. Only one patient reported experiencing myalgia and proximal muscle weakness, in addition to fatigue and chills. Creatine kinase, lactate dehydrogenase, and renal function normalized after thyroid hormone replacement, except in two patients who improved through blood purification.
  
  
  CONCLUSIONS
  Hypothyroidism should be considered in patients presenting with renal impairment associated with rhabdomyolysis. Moreover, further investigation into the etiology of the hypothyroidism is warranted.
authors.affiliation: Department of Nephrology, the Second Affiliated Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cai
authors.forename: Lin
authors.initials: L
authors.lastname: Tang
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy; D000328:Adult; D000638:Amiodarone / Q000009:adverse effects; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D007677:Kidney Function Tests; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012206:Rhabdomyolysis / Q000175:diagnosis / Q000209:etiology*; D013967:Thyroiditis, Autoimmune / Q000150:complications; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000009:adverse effects
chemical_list: D014665:Vasodilator Agents; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D000638:Amiodarone