title: Facile synthesis of multicompartment micelles based on biocompatible poly(3-hydroxyalkanoate).
abstract: In this paper, a straightforward method to produce poly(3-hydroxyalkanoate)-based multicompartment micelles (MCMs) is presented. Thiol-ene addition is used to graft sequentially perfluorooctyl chains and poly(ethylene glycol) oligomers onto poly(3-hydroxyoctanoate-co-hydroxyundecenoate) oligomers backbone. Well-defined copolymers are obtained as shown by ¹H NMR and size-exclusion chromatography. After nanoprecipitation in water, novel PHA-based MCMs are evidenced by cryo-transmission electron microscopy. Moreover, the cytocompatibility of MCMs is demonstrated in vitro via cell viability assay.
authors.affiliation: Institut de Chimie et des Matériaux Paris-Est (ICMPE), Systèmes Polymères Complexes, UMR CNRS 7182, 2-8 rue Henri Dunant, 94320 Thiais, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Babinot
authors.forename: Estelle
authors.initials: E
authors.lastname: Renard
authors.forename: Benjamin
authors.initials: B
authors.lastname: Le Droumaguet
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Guigner
authors.forename: Simona
authors.initials: S
authors.lastname: Mura
authors.forename: Julien
authors.initials: J
authors.lastname: Nicolas
authors.forename: Patrick
authors.initials: P
authors.lastname: Couvreur
authors.forename: Valérie
authors.initials: V
authors.lastname: Langlois
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D008027:Light; D051379:Mice; D008823:Micelles; D041681:NIH 3T3 Cells; D049329:Nanostructures / Q000737:chemistry; D054813:Polyhydroxyalkanoates / Q000737:chemistry* / Q000633:toxicity; D012542:Scattering, Radiation; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D000475:Alkenes; D001672:Biocompatible Materials; D008823:Micelles; D054813:Polyhydroxyalkanoates; D013438:Sulfhydryl Compounds