title: Differentiating between gestational and chronic hypertension; an explorative study.
abstract: OBJECTIVE
  Guidelines define hypertension diagnosed before 20 weeks' gestation as chronic hypertension (CH) and thereafter as gestational hypertension (GH). We tested whether hypertension diagnosed before 20 weeks is preceded by CH and whether pregnancy outcome depends on the time of onset of hypertension.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Tertiary obstetric center.
  
  
  METHODS
  Women with a history of obstetric vascular complications.
  
  
  METHODS
  Blood pressure data prior to and during pregnancy and subsequent maternal and neonatal outcome were reviewed in 148 women. Women were grouped according to the onset of hypertension; pre-pregnancy (CH), before 20 weeks' (early GH), after 20 weeks' gestation (late GH) and normotensive.
  
  
  METHODS
  Onset of hypertension, obstetric complications (pre-eclampsia, HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome, intra-uterine growth restriction).
  
  
  RESULTS
  Twenty-nine women had CH. Early GH occurred in 46 women and another 32 developed late GH. Of 75 women with hypertension in the first half of pregnancy, 29 (39%) had CH and 46 (61%) early GH. Obstetric complications occurred more often in all hypertensive women, but no differences between the CH and GH groups could be detected.
  
  
  CONCLUSIONS
  Hypertension detected in the first half of pregnancy does not necessarily indicate chronic hypertension. Hypertension in general is related to hypertensive maternal complications and fetal growth restriction. Differentiating between chronic or gestational hypertension does not seem to help in establishing the risk for later hypertensive sequelae or intra-uterine growth restriction.
authors.affiliation: Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands. j.terwisschavanscheltinga@obgyn.umcn.nl
authors.forename: Josien A
authors.initials: JA
authors.lastname: Terwisscha van Scheltinga
authors.forename: Ineke
authors.initials: I
authors.lastname: Krabbendam
authors.forename: Marc E A
authors.initials: ME
authors.lastname: Spaanderman
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D005865:Gestational Age; D017359:HELLP Syndrome / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis*; D011225:Pre-Eclampsia / Q000209:etiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000209:etiology; D047928:Premature Birth / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors