title: Diabetes is associated with drug-resistant tuberculosis in Eastern Taiwan.
abstract: We assessed the association between diabetes mellitus and drug-resistant tuberculosis (TB). Among new patients, diabetes was significantly associated with any resistance to isoniazid excluding multidrug-resistant TB (MDR-TB; adjusted OR [aOR] 1.88, 95%CI 1.07-3.31), but not with  MDR-TB (aOR 0.95, 95%CI 0.34-2.68). Among previously treated patients, diabetes was also significantly associated with INH resistance (aOR 6.76, 95%CI 1.53-29.98) but not with MDR-TB (aOR 1.52, 95%CI 0.59-3.95). We concluded that diabetes was associated with INH resistance  and speculated that the sample size of retreatment cases was insufficient to confirm the association between diabetes and MDR-TB.
authors.affiliation: Department of Internal Medicine, Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan.
authors.forename: A-H
authors.initials: AH
authors.lastname: Hsu
authors.forename: J-J
authors.initials: JJ
authors.lastname: Lee
authors.forename: C-Y
authors.initials: CY
authors.lastname: Chiang
authors.forename: Y-H
authors.initials: YH
authors.lastname: Li
authors.forename: L-K
authors.initials: LK
authors.lastname: Chen
authors.forename: C-B
authors.initials: CB
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007538:Isoniazid / Q000627:therapeutic use*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid