title: [The coronary arteries and the determinants of coronary atherosclerosis in rheumatoid arthritis].
abstract: Fifty-three women, including 32 patients with rheumatoid arthritis (RA) (a study group) and 21 individuals (a control group), were examined. In the study and control group, the patients' mean age was 49 +/- 7.4 and 47 +/- 9 years, respectively. The coronary arteries were examined using a GE LightSpeed VCT 64-slice computed tomograph. Coronary calcium was measured by SmartScore software; calcium index was determined by the Agatston score. Coronary artery changes were diagnosed in 44 and 19% in the study and control groups, respectively. Coronary artery calcification was detected in 27% of the patients with RA. In the latter, there was a predominance of multiple coronary artery lesions with more severe stenosis and a number of atherosclerotic plaques. Hemodynamically relevant stenoses were diagnosed only in patients with RA. Coronary artery atherosclerosis was found to be associated with the duration of menopause, the higher levels of total cholesterol and low-density lipoproteins, the lower levels of superoxide dismutase, the high activity of RA and the number of involved joints. The degree of coronary stenosis is associated with the level of systolic blood pressure.
authors.forename: A V
authors.initials: AV
authors.lastname: Sineglazova
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000209:etiology; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D008593:Menopause / Q000378:metabolism; D008875:Middle Aged; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D036542:Tomography, Spiral Computed / Q000379:methods*
chemical_list: D013482:Superoxide Dismutase