title: Histone deacetylases enzyme, copper, and IL-8 levels in patients with Alzheimer's disease.
abstract: BACKGROUND
  Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive abilities. Epigenetic modification, oxidative stress, and inflammation play an important role in the pathogenesis of the disease. We aimed to detect noninvasive peripheral biomarkers with a high degree of sensitivity and specificity in diagnosis and progression of AD.
  
  
  METHODS
  A total of 25 elderly patients with AD and 25 healthy control participants were selected and subjected to cognitive assessment and laboratory measures including histone deacetylases (HDACs), copper, and interleukin 8 (IL-8) levels.
  
  
  RESULTS
  The levels of HDACs, copper, and IL-8 were significantly higher in patients with AD (P < .001) and had a significant negative effect on all cognitive assessment tests. Receiver-operating curve (ROC) analysis revealed that HDACs and copper levels had higher sensitivity and specificity.
  
  
  CONCLUSIONS
  Plasma levels of HDACs and copper may be used as peripheral biomarkers in diagnosis of AD, while IL-8 level could be a useful biomarker in following AD progression.
authors.affiliation: Geriatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. mohamadalsadany@hotmail.com
authors.forename: Mohamad A
authors.initials: MA
authors.lastname: Alsadany
authors.forename: Hanan H
authors.initials: HH
authors.lastname: Shehata
authors.forename: Magda I
authors.initials: MI
authors.lastname: Mohamad
authors.forename: Riham G
authors.initials: RG
authors.lastname: Mahfouz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D003072:Cognition Disorders / Q000097:blood / Q000175:diagnosis; D003300:Copper / Q000097:blood*; D018450:Disease Progression; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D015577:Geriatric Assessment; D006655:Histone Deacetylases / Q000097:blood*; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D015854:Up-Regulation / Q000502:physiology
chemical_list: D015415:Biomarkers; D016209:Interleukin-8; D003300:Copper; D006655:Histone Deacetylases