title: Antioxidant therapy in nonalcoholic steatohepatitis.
abstract: Nonalcoholic steatohepatitis (NASH) affects up to 3% of the North American population. It occurs as a manifestation of the insulin-resistant state and oxidative stress is thought to be a key component of its pathophysiology. Exercise and diet, which are the mainstay of therapy, are difficult to achieve and maintain with a disappointing long-term compliance record. There is growing literature on the potential for antioxidant therapy. The recent literature strongly suggests that vitamin E supplementation and other putative free radical scavengers and/or antioxidants are beneficial in improving biochemical and histological parameters in NASH.
authors.affiliation: Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Alkhoudh, Muscat 123, Oman ; Department of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, QC, Canada H3A 1A1.
authors.forename: Said A
authors.initials: SA
authors.lastname: Al-Busafi
authors.forename: Mamatha
authors.initials: M
authors.lastname: Bhat
authors.forename: Philip
authors.initials: P
authors.lastname: Wong
authors.forename: Peter
authors.initials: P
authors.lastname: Ghali
authors.forename: Marc
authors.initials: M
authors.lastname: Deschenes