title: Cytokine control of inflammation and repair in the pathology of multiple sclerosis.
abstract: Cytokines are secreted signaling proteins that play an essential role in propagating and regulating immune responses during experimental autoimmune encephalomyelitis (EAE), the mouse model of the neurodegenerative, autoimmune disease multiple sclerosis (MS). EAE pathology is driven by a myelin-specific T cell response that is activated in the periphery and mediates the destruction of myelin upon T cell infiltration into the central nervous system (CNS). Cytokines provide cell signals both in the immune and CNS compartment, but interestingly, some have detrimental effects in the immune compartment while having beneficial effects in the CNS compartment. The complex nature of these signals will be reviewed.
authors.affiliation: Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
authors.forename: Jane M
authors.initials: JM
authors.lastname: Rodgers
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Miller
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D002451:Cell Compartmentation; D016207:Cytokines / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000378:metabolism / Q000503:physiopathology; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology*; D051379:Mice; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology
chemical_list: D016207:Cytokines