title: Immunomodulator drug-based therapy in myeloma and the occurrence of thrombosis.
abstract: Immunomodulator drugs (IMiDs) have contributed to the significant improvement observed in the survival of myeloma patients since the introduction of novel targeted therapies. The introduction of IMiDs in the myeloma pipeline has also significantly increased the incidence rate of thromboembolic events, either venous and/or arterial. The observation of an increasing number of deep venous thrombosis makes it compulsory to discuss prophylactic options in myeloma, particularly in those treated with IMiDs as immunomodulatory drugs. Although an attempt to propose guidelines was performed, it is clear that several questions remain unanswered, starting with the choice of the thromboprophylaxis and the definition of risk factors. We have reviewed evidence that might help to decide the optimal thromboprophylaxis, and also highlighted the unresolved area where further study is warranted.
authors.affiliation: Service des Maladies du Sang, Hôpital Huriez, CHRU, Lille, France.
authors.forename: Eileen M
authors.initials: EM
authors.lastname: Boyle
authors.forename: Guillemette
authors.initials: G
authors.lastname: Fouquet
authors.forename: Salomon
authors.initials: S
authors.lastname: Manier
authors.forename: Jordan
authors.initials: J
authors.lastname: Gauthier
authors.forename: Marie Pierre
authors.initials: MP
authors.lastname: Noel
authors.forename: Claire
authors.initials: C
authors.lastname: Borie
authors.forename: Thierry
authors.initials: T
authors.lastname: Facon
authors.forename: Ismail
authors.initials: I
authors.lastname: Elalamy
authors.forename: Xavier
authors.initials: X
authors.lastname: Leleu
mesh_terms: D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects* / Q000627:therapeutic use*; D009101:Multiple Myeloma / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D012307:Risk Factors; D013927:Thrombosis / Q000139:chemically induced* / Q000517:prevention & control
chemical_list: D007155:Immunologic Factors