title: Intermediate uveitis, an ophthalmological manifestation of systemic disease.
abstract: OBJECTIVE
  Intermediate uveitis is frequently indicative associated with systemic disease. In addition to the initial evaluation of the patient with intermediate uveitis, we sought to determine the role of longitudinal follow-up in improving the diagnosis of systemic disease associated with intermediate uveitis.
  
  
  METHODS
  Retrospective analysis of a cohort of 51 patients with intermediate uveitis followed for 5 to 13 years.
  
  
  RESULTS
  Upon initial evaluation, an underlying disease associated with the intermediate uveitis was found in nine out of the 51 patients. Among the remaining patients, after at least 5 years of follow-up, eight new associated diagnoses were revealed (primarily inflammatory diseases and cancers).
  
  
  CONCLUSIONS
  These results suggest that the initial work-up of the patient with intermediate uveitis is not sufficiently sensitive and that careful follow-up of these patients considerably improves the diagnosis of associated disease.
authors.affiliation: Clinical immunology and internal medicine, National reference Center for Rare Autoimmune Diseases, CHRU Strasbourg, university of Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Vincent.poindron@chru-strasbourg.fr
authors.forename: V
authors.initials: V
authors.lastname: Poindron
authors.forename: G
authors.initials: G
authors.lastname: Camuset
authors.forename: D
authors.initials: D
authors.lastname: Krencker
authors.forename: L
authors.initials: L
authors.lastname: Ballonzoli
authors.forename: O-K
authors.initials: OK
authors.lastname: Naoun
authors.forename: N
authors.initials: N
authors.lastname: Kennel
authors.forename: C
authors.initials: C
authors.lastname: Speeg
authors.forename: J-L
authors.initials: JL
authors.lastname: Pasquali
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D007239:Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D007249:Inflammation / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D012189:Retrospective Studies; D015867:Uveitis, Intermediate / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D055815:Young Adult