title: Tag-assisted liquid-phase peptide synthesis using hydrophobic benzyl alcohols as supports.
abstract: A soluble tag-assisted liquid-phase peptide synthesis was successfully established based on simple hydrophobic benzyl alcohols, which can be easily prepared from naturally abundant materials. Excellent precipitation yields can be obtained at each step, combining the best properties of solid-phase and liquid-phase techniques. This approach can also be applied efficiently to fragment couplings, allowing chemical synthesis of several bioactive peptides.
authors.affiliation: Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Okada
authors.forename: Hideaki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakae
authors.forename: Shuji
authors.initials: S
authors.lastname: Fujita
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Abe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagano
authors.forename: Toshihide
authors.initials: T
authors.lastname: Yamada
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Ebata
authors.forename: Shokaku
authors.initials: S
authors.lastname: Kim
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Chiba
mesh_terms: D000595:Amino Acid Sequence; D001592:Benzyl Alcohols / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D057927:Hydrophobic and Hydrophilic Interactions; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001592:Benzyl Alcohols; D010455:Peptides