title: New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation.
abstract: Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxal scavengers and as AGE inhibitors. Addition of an 8-hydroxyquinoline moiety led to an increase of the overall activity. The compounds tested in this study were also proved to be efficient in trapping ALE precursor malondialdehyde.
authors.affiliation: Pharmamens, 9 avenue Théophile Gautier, 75016 Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Audic
authors.forename: Guy
authors.initials: G
authors.lastname: Potier
authors.forename: N André
authors.initials: NA
authors.lastname: Sasaki
mesh_terms: D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006037:Glyoxal / Q000378:metabolism*; D006801:Humans; D015125:Oxyquinoline / Q000737:chemistry / Q000494:pharmacology; D011765:Pyruvaldehyde / Q000378:metabolism*; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D017127:Glycation End Products, Advanced; D015091:beta-Alanine; D006037:Glyoxal; D015125:Oxyquinoline; D011765:Pyruvaldehyde; C011757:2,3-diaminopropionic acid