title: Human Th17 cells in patients with cancer: Friends or foe?
abstract: The role of interleukin-17 (IL-17)-secreting CD4(+) T (Th17) cells in cancer is under intense investigation. We have demonstrated that CCR4(+)CCR6(+) Th17 cells not only are increased in the peripheral blood of patients affected by hepatocellular carcinoma, but also suppress CD8(+) T-cell functions in vitro. These results suggest that Th17 cells may exert immunosuppressive functions in hepatocellular carcinoma.
authors.affiliation: Gastrointestinal Malignancy Section; Medical Oncology Branch; National Cancer Institute; Bethesda, MD USA.
authors.forename: Tim F
authors.initials: TF
authors.lastname: Greten
authors.forename: Fei
authors.initials: F
authors.lastname: Zhao
authors.forename: Jaba
authors.initials: J
authors.lastname: Gamrekelashvili
authors.forename: Firouzeh
authors.initials: F
authors.lastname: Korangy