title: Amylin level and gastric emptying in obese children: before and after weight loss.
abstract: Amylin is a neuroendocrine hormone that inhibits food intake and gastric emptying in animal studies. Its role in obese human beings is still controversial. We aimed to estimate the fasting and postprandial amylin levels in obese children before and after weight loss [through weight loss intervention program (WLIP)] and to relate these levels to the lipid profile, homeostasis model assessment of insulin resistance (HOMA-IR) and ultrasonography gastric half emptying time (t1/2). This study was conducted initially on 20 obese children, 10 of them only continued 6 months follow up strategy on WLIP. Ten lean children served as controls. All children were subjected initially and on follow up to dietetic history taking, anthropometric measurements and laboratory assessment oflipid profile, HOMA-IR, fasting and postprandial amylin levels and ultrasonography gastric half emptying time (t1/2). The results showed that IR, significantly increased in fasting and postprandial amylin levels and significant delay in gastric emptying among obese children. After WLIP completion, IR was reversible, fasting and postprandial amylin levels decreased and gastric emptying significantly improved yet still significantly delayed than controls. There was significant positive correlation between fasting amylin levels and body mass index %, fasting insulin and HOMA-IR.
authors.affiliation: Department of Pediatric, Faculty of Medicine Ain Shams University, Cairo 11566, Egypt.
authors.forename: Omnia F
authors.initials: OF
authors.lastname: El-Rasheidy
authors.forename: Dina A
authors.initials: DA
authors.lastname: Amin
authors.forename: Hala A
authors.initials: HA
authors.lastname: Ahmed
authors.forename: Hesham
authors.initials: H
authors.lastname: El Masry
authors.forename: Zeinab M
authors.initials: ZM
authors.lastname: Montaser
mesh_terms: D000886:Anthropometry; D001521:Behavior Therapy; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004032:Diet / Q000592:standards; D015444:Exercise; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D007333:Insulin Resistance; D058228:Islet Amyloid Polypeptide / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D010353:Patient Education as Topic; D010865:Pilot Projects; D011446:Prospective Studies; D015431:Weight Loss / Q000502:physiology
chemical_list: D058228:Islet Amyloid Polypeptide; D008055:Lipids