title: Prevalence and potentially reversible factors associated with anorexia among older nursing home residents: results from the ULISSE project.
abstract: OBJECTIVE
  The principal aims of the present study were to explore the prevalence of anorexia and the factors correlated to anorexia in a large population of older people living in nursing home. Secondary, we evaluated the impact of anorexia on 1-year survival.
  
  
  METHODS
  Data are from baseline evaluation of 1904 participants enrolled in the Un Link Informatico sui Servizi Sanitari Esistenti per l'Anziano study, a project evaluating the quality of care for older persons living in an Italian nursing home. All participants underwent a standardized comprehensive evaluation using the Italian version of the inter Resident Assessment Instrument Minimum Data Set (version 2.0) for Nursing Home. We defined anorexia as the presence of lower food intake. The relationship between covariates and anorexia was estimated by deriving ORs and relative 95% CIs from multiple logistic regression models including anorexia as the dependent variable of interest. Hazard ratios and 95% CIs for mortality by anorexia were calculated.
  
  
  RESULTS
  More than 12% (240 participants) of the study sample suffered from anorexia, as defined by the presence of decreased food intake or the presence of poor appetite. Participants with functional impairment, dementia, behavior problems, chewing problems, renal failure, constipation, and depression, those treated with proton pump inhibitors and opioids had a nearly 2-fold increased risk of anorexia compared with participants not affected by these syndromes. Furthermore, participants with anorexia had a higher risk of death for all causes compared with nonanorexic participants (hazard ratio 2.26, 95% CI: 2.14-2.38).
  
  
  CONCLUSIONS
  The major finding is that potentially reversible causes, such as depression, pharmacologic therapies, and chewing problems, were strongly and independently associated with anorexia among frail older people living in nursing home. Furthermore, anorexia was associated with higher rate of mortality, independently of age and other clinical and functional variables.
authors.affiliation: Department of Gerontology and Geriatric, Catholic University of Sacred Heart, Rome, Italy. Francesco.landi@rm.unicatt.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Landi
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Lattanzio
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Dell'Aquila
authors.forename: Paolo
authors.initials: P
authors.lastname: Eusebi
authors.forename: Beatrice
authors.initials: B
authors.lastname: Gasperini
authors.forename: Rosa
authors.initials: R
authors.lastname: Liperoti
authors.forename: Andrea
authors.initials: A
authors.lastname: Belluigi
authors.forename: Roberto
authors.initials: R
authors.lastname: Bernabei
authors.forename: Antonio
authors.initials: A
authors.lastname: Cherubini
mesh_terms: D000203:Activities of Daily Living; D000369:Aged, 80 and over; D000855:Anorexia / Q000453:epidemiology* / Q000517:prevention & control*; D003072:Cognition Disorders / Q000453:epidemiology; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D007558:Italy / Q000453:epidemiology; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008390:Markov Chains; D009010:Monte Carlo Method; D009735:Nursing Homes; D015995:Prevalence; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D015996:Survival Rate