title: The Addenbrooke's Cognitive Examination Revised is as effective as the original to detect dementia in a French-speaking population.
abstract: BACKGROUND
  This paper presents the validation of the French version of the Addenbrooke's Cognitive Examination Revised (ACE-R).
  
  
  METHODS
  The variability of the 3 versions of the ACE-R (A, B and C), performed by the same observer, hence mainly 2 or 3 times on 119 patients showing no progression, was first calculated by Cronbach's alpha coefficient, t test and linear regression. The alpha coefficients of the 3 versions were obtained showing that the ACE-R versions can be considered as one, and an analysis of the interobserver variability was performed by Cohen's kappa coefficient, t test and linear regression on 12 patients. Eventually, we performed a receiver operating characteristic (ROC) analysis to compare the sensitivities and specificities to detect dementia of the ACE, the ACE-R and Mini Mental State Examination on 319 consecutive patients.
  
  
  RESULTS
  The ROC areas of sensitivities and specificities of the ACE and ACE-R were very similar. Two cutoffs were identified at 83/100 and 89/100 with a specificity to normality of 98.6% if the ACE-R score was ≥83 and a sensitivity to dementia of 98.4% if the ACE-R score was ≤89.
  
  
  CONCLUSIONS
  ACE-R in French is as reliable and valid as the original version to detect dementia.
authors.affiliation: Departments of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Bastide
authors.forename: S
authors.initials: S
authors.lastname: De Breucker
authors.forename: M
authors.initials: M
authors.lastname: Van den Berge
authors.forename: P
authors.initials: P
authors.lastname: Fery
authors.forename: T
authors.initials: T
authors.lastname: Pepersack
authors.forename: J C
authors.initials: JC
authors.lastname: Bier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis; D003071:Cognition / Q000502:physiology*; D003704:Dementia / Q000175:diagnosis* / Q000523:psychology*; D005260:Female; D005602:France; D006801:Humans; D007802:Language; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015588:Observer Variation; D012372:ROC Curve; D015203:Reproducibility of Results