title: New mycotoxins from marine-derived fungus Aspergillus sp. SCSGAF0093.
abstract: Nine mycotoxins including six aspergillic acid group toxins, aluminiumneoaspergillin (1), zirconiumneoaspergillin (2), aspergilliamide (3), ferrineoaspergillin (5), flavacol (6), neoaspergillic acid (7), and three ochratoxins, ochratoxin A n-butyl ester (4), ochratoxin A (8), ochratoxin A methyl ester (9), were isolated from the fermentation broth of marine gorgonian derived fungus Aspergillus sp. SCSGAF0093. Four of them (1-4) were new mycotoxins, and their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. The bio-toxicity of compounds 1-9 were determined by brine shrimp lethality bioassay with median lethal concentration (LC(50)) values of 2.59-205.67 μM. This was the first report about zirconium complex obtained from nature and ochratoxins isolated from marine environment.
authors.affiliation: Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
authors.forename: Xinya
authors.initials: X
authors.lastname: Xu
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Bao
authors.forename: Shuhua
authors.initials: S
authors.lastname: Qi
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry; D059001:Aquatic Organisms; D001156:Artemia / Q000187:drug effects; D001230:Aspergillus / Q000378:metabolism*; D001681:Biological Assay / Q000379:methods; D004784:Environmental Monitoring / Q000379:methods; D005285:Fermentation; D007928:Lethal Dose 50; D015394:Molecular Structure; D009183:Mycotoxins / Q000302:isolation & purification* / Q000633:toxicity; D009793:Ochratoxins / Q000032:analysis; D011719:Pyrazines / Q000302:isolation & purification* / Q000633:toxicity; D014874:Water Pollutants, Chemical / Q000302:isolation & purification* / Q000633:toxicity; D015040:Zirconium / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D009183:Mycotoxins; D009793:Ochratoxins; D011719:Pyrazines; C582884:SCSGAF0093; D014874:Water Pollutants, Chemical; D015040:Zirconium