title: Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: novel prognostic factors of nasopharyngeal carcinoma.
abstract: Nasopharyngeal carcinoma (NPC) is an EBV-associated cancer. We analysed Siah1 expression as well as LMP1 and HIF1α expression by immuno-histochemical staining in 74 NPC biopsy specimens and found that the expression of Siah1 was significantly correlated with advanced tumour status and stage. Moreover, Siah1-positive and HIF1α-positive cases had significantly worse prognoses. The expression score for LMP1 was remarkably correlated with that of Siah1, whereas there was little correlation between LMP1 expression and the other markers evaluated. This is the first study to evaluate the pattern and clinical significance of Siah1 and HIF1α expression in NPC, and such an evaluation is valuable for identifying those patients at a high risk for a poor prognosis.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Takara-machi 13-1, Kanazawa, Ishikawa 920-8640, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Kitagawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Kondo
authors.forename: Naohiro
authors.initials: N
authors.lastname: Wakisaka
authors.forename: Yoh
authors.initials: Y
authors.lastname: Zen
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Akira
authors.initials: A
authors.lastname: Tsuji
authors.forename: Kazuhira
authors.initials: K
authors.lastname: Endo
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Murono
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Yoshizaki
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011379:Prognosis; D015996:Survival Rate; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014763:Viral Matrix Proteins / Q000378:metabolism*; D000098563:Seven in Absentia Proteins
chemical_list: D014408:Biomarkers, Tumor; D004279:DNA, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D014763:Viral Matrix Proteins; D044767:Ubiquitin-Protein Ligases; D000098563:Seven in Absentia Proteins