title: Nematicidal activity of chaetoglobosin A poduced by Chaetomium globosum NK102 against Meloidogyne incognita.
abstract: The nematicidal activity of  Chaetomium globosum  NK102, culture filtrates, and chaetoglobosin A (ChA) purified by HPLC was evaluated on  Meloidogyne incognita . The results showed that C. globosum NK102 significantly repelled second-stage juveniles (J2s). Both filtrates and ChA demonstrated strong adverse effects on J2 mortality with 99.8% at 300 μg ChA/mL (LC(50) = 77.0 μg/mL) at 72 h. ChA and filtrates did not affect egg hatch until 72 h of exposure. All filtrate treatments inhibited the J2 penetration even in 12.5% dilution treatment. Similarly, ChA (300 and 30 μg/mL) showed a significant inhibitory effect on J2 penetration. The number of eggs per plant was significantly reduced in the treatment of 30 mg ChA/kg soil by 63% relative to control plants, indicating the apparent negative effect on reproduction of M. incognita. The study demonstrated the nematicidal activity of ChA and suggested that it could be a potential biocontrol agent for integrated management of M. incognita.
authors.affiliation: State Key Program of Microbiology and Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
authors.forename: Weipu
authors.initials: W
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Weibin
authors.initials: W
authors.lastname: Ruan
authors.forename: Xudong
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000969:Antinematodal Agents; D002597:Chaetomium / Q000378:metabolism*; D004531:Eggs; D026121:Indole Alkaloids / Q000378:metabolism / Q000494:pharmacology*; D014431:Tylenchoidea / Q000187:drug effects*
chemical_list: D000969:Antinematodal Agents; D026121:Indole Alkaloids; C019290:chaetoglobosins