title: Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis.
abstract: The purpose of this study was to investigate whether platelet-rich plasma therapy for early knee osteoarthritis is associated with good clinical outcomes and a change in magnetic resonance imaging (MRI) structural appearances. The design was a prospective cohort study following patients 1 year after platelet-rich plasma therapy for knee osteoarthritis. Twenty-two patients were treated with platelet-rich plasma for early osteoarthritis, confirmed with a baseline MRI. Inclusion criteria were Kellgren grade 0-II with knee pain in patients aged 30 to 70 years. All the patients received a 6-mL platelet-rich plasma injection using the Cascade system. Fifteen subjects underwent clinical assessments at baseline, 1 week, and 1, 3, 6, and 12 months, and MRIs at 1 year. Pain scores significantly decreased, whereas functional and clinical scores increased at 6 months and 1 year from baseline. Qualitative MRIs demonstrated no change per compartment in at least 73% of cases at 1 year.
authors.affiliation: Hospital for Special Surgery, New York, New York 10021, USA. halpernb@hss.edu
authors.forename: Brian
authors.initials: B
authors.lastname: Halpern
authors.forename: Salma
authors.initials: S
authors.lastname: Chaudhury
authors.forename: Scott A
authors.initials: SA
authors.lastname: Rodeo
authors.forename: Catherine
authors.initials: C
authors.lastname: Hayter
authors.forename: Eric
authors.initials: E
authors.lastname: Bogner
authors.forename: Hollis G
authors.initials: HG
authors.lastname: Potter
authors.forename: Joseph
authors.initials: J
authors.lastname: Nguyen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D053657:Platelet-Rich Plasma; D011446:Prospective Studies