title: Intratumoral TNFα improves immunotherapy.
abstract: Solid tumors are frequently resistant to immunotherapy. We demonstrated that low-dose tumor necrosis factorα (TNFα), when directly targeted to the tumor environment, exerts dual effects by improving vessel functionality and activating immune cells. This vascular remodeling in an inflammatory context enhances active immunotherapy and promotes tumor regression.
authors.affiliation: Western Australian Institute for Medical Research; University of Western Australia Centre for Medical Research; Laboratory for Cancer Medicine; Perth, WA Australia.
authors.forename: Anna
authors.initials: A
authors.lastname: Johansson
authors.forename: Juliana
authors.initials: J
authors.lastname: Hamzah
authors.forename: Ruth
authors.initials: R
authors.lastname: Ganss