title: Naturally selecting solutions: the use of genetic algorithms in bioinformatics.
abstract: For decades, computer scientists have looked to nature for biologically inspired solutions to computational problems; ranging from robotic control to scheduling optimization. Paradoxically, as we move deeper into the post-genomics era, the reverse is occurring, as biologists and bioinformaticians look to computational techniques, to solve a variety of biological problems. One of the most common biologically inspired techniques are genetic algorithms (GAs), which take the Darwinian concept of natural selection as the driving force behind systems for solving real world problems, including those in the bioinformatics domain. Herein, we provide an overview of genetic algorithms and survey some of the most recent applications of this approach to bioinformatics based problems.
authors.affiliation: Department of Computer Science; Cork Institute of Technology; Cork, Ireland; Department of Biological Sciences; Cork Institute of Technology; Cork, Ireland.
authors.forename: Timmy
authors.initials: T
authors.lastname: Manning
authors.forename: Roy D
authors.initials: RD
authors.lastname: Sleator
authors.forename: Paul
authors.initials: P
authors.lastname: Walsh
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D003434:Crossing Over, Genetic; D056084:Genetic Fitness; D005838:Genotype; D008957:Models, Genetic; D010641:Phenotype; D012641:Selection, Genetic; D016415:Sequence Alignment