title: Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens.
abstract: Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolytic activity against tumor cells, and CD4 T cells mount a variety of responses that have important influences on tumor growth. We discuss how individual T-cell subsets contribute to antitumor responses and the goals and problems associated with generating and/or maintaining effective multifunctional T-cell responses to provide long-term protection against tumors.
authors.affiliation: Institute of Immunology and Infection Research, The University of Edinburgh, Edinburgh, UK.
authors.forename: Stefano
authors.initials: S
authors.lastname: Caserta
authors.forename: Jessica Geraldine
authors.initials: JG
authors.lastname: Borger
authors.forename: Rose
authors.initials: R
authors.lastname: Zamoyska
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007156:Immunologic Memory; D016219:Immunotherapy, Adoptive / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy
chemical_list: D000951:Antigens, Neoplasm