title: Puncture injection of para-toluenesulfonamide combined with chemoembolization for advanced hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is difficult to eradicate due to its resilient nature. Portal vein is often involved in tumors of large size, which exclude the patient from surgical resection and local ablative therapy, such as percutaneous ethanol injection (PEI) and radiofrequency ablation (RFA) because they were considered neither effective nor safe. Currently, there is almost no effective treatment for HCC of such condition. As a unique antitumor agent in form of lipophilic fluid for local injection, para-toluenesulfonamide (PTS) produces mild side effects while necrotizing the tumor tissues quickly and efficiently. Being largely different from both PEI and RFA therapies, PTS can disseminate itself in tumors more easily than other caustic agents, such as alcohol. So PTS may offer additional benefit to HCCs with vascular involvement. We herein describe a 70-year-old HCC patient who was treated with the combination of PTS injection and transcatheter arterial chemoembolization, resulting in a significantly improved clinical prognosis.
authors.affiliation: Department of Oncology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.forename: An-Ren
authors.initials: AR
authors.lastname: Kuang
authors.forename: Yong-Song
authors.initials: YS
authors.lastname: Guan
authors.forename: Yue-Qing
authors.initials: YQ
authors.lastname: Liu
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D017115:Catheter Ablation / Q000379:methods; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D009336:Necrosis; D011379:Prognosis; D011677:Punctures; D013449:Sulfonamides / Q000008:administration & dosage*; D014050:Toluene / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016896:Treatment Outcome; D000096926:Benzenesulfonamides
chemical_list: D000970:Antineoplastic Agents; D013449:Sulfonamides; D014050:Toluene; C025417:4-toluenesulfonamide; D000096926:Benzenesulfonamides