title: High overexpression of fatty acid synthase is associated with poor survival in Chinese patients with gastric carcinoma.
abstract: Fatty acid synthase (FAS) is the key enzyme regulating de novo biosynthesis of fatty acids. FAS overexpression has been found in many types of tumors and is associated with poor survival. However, the expression of FAS and its relationship with prognosis in Chinese patients with gastric carcinoma are still unknown. Therefore, in this study, we examined the expression of FAS using tissue microarrays and determined its correlation with clinicopathological characteristics and prognosis of gastric carcinoma in Chinese patients. FAS overexpression was graded as S (T/A) <1, ≥1 to <2, ≥2 to <3 or ≥3 in 35 (38.9%), 20 (22.2%), 9 (10%) and 26 (28.9%) patients, respectively. High FAS overexpression [S (T/A) ≥3] was significantly correlated with poor prognosis (log-rank test, P= 0.0078) and with decreased 3-year survival rate (χ(2) test, P=0.0023). FAS overexpression was not significantly associated with other clinicopathological characteristics. In conclusion, our results suggest that FAS expression might be a potential prognostic marker for gastric carcinoma in Chinese patients.
authors.affiliation: Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology; ; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences;
authors.forename: Wenmin
authors.initials: W
authors.lastname: Hou
authors.forename: Maogui
authors.initials: M
authors.lastname: Fei
authors.forename: Xia
authors.initials: X
authors.lastname: Qin
authors.forename: Xuehua
authors.initials: X
authors.lastname: Zhu
authors.forename: Joel
authors.initials: J
authors.lastname: Greshock
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Yuanfeng
authors.initials: Y
authors.lastname: Zhou
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Bang-Ce
authors.initials: BC
authors.lastname: Ye
authors.forename: Crystal Ying
authors.initials: CY
authors.lastname: Qin