title: Weber-Christian disease associated with the tip variant of focal segmental glomerulosclerosis: a case report.
abstract: Weber-Christian disease (W-CD) is associated with relapsing nodular panniculitis and a variety of systemic findings. Renal parenchymal involvement has been rarely reported. The authors describe a case of nephrotic syndrome in an African-American man with a W-CD flare. The patient had chills and low-grade fever with painful lower extremity skin lesions. A renal biopsy demonstrated the tip variant of focal segmental glomerulosclerosis (FSGS). The kidney biopsy also suggested parenchymal involvement by W-CD disease, with supportive ultrastructural findings. The synchronous W-CD flare and biopsy-proven FSGS and the rapid and sustained response of both to limited treatment suggest a causative association.
authors.affiliation: Division of Kidney Disease and Hypertension, George Washington University School of Medicine, Washington, DC 20037, USA. sterling_kevin@hotmail.com
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Sterling
authors.forename: Sabine
authors.initials: S
authors.lastname: Karam
authors.forename: Nora
authors.initials: N
authors.lastname: Taylor
authors.forename: Helen P
authors.initials: HP
authors.lastname: Cathro
mesh_terms: D001706:Biopsy; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology / Q000473:pathology; D010201:Panniculitis, Nodular Nonsuppurative / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D011237:Predictive Value of Tests; D013256:Steroids / Q000627:therapeutic use
chemical_list: D013256:Steroids