title: Somatostatinergic systems: an update on brain functions in normal and pathological aging.
abstract: Somatostatin is highly expressed in mammalian brain and is involved in many brain functions such as motor activity, sleep, sensory, and cognitive processes. Five somatostatin receptors have been described: sst(1), sst(2) (A and B), sst(3), sst(4), and sst(5), all belonging to the G-protein-coupled receptor family. During the recent years, numerous studies contributed to clarify the role of somatostatin systems, especially long-range somatostatinergic interneurons, in several functions they have been previously involved in. New advances have also been made on the alterations of somatostatinergic systems in several brain diseases and on the potential therapeutic target they represent in these pathologies.
authors.affiliation: Inserm UMR894 - Center for Psychiatry and Neuroscience, Université Paris Descartes, Sorbonne Paris Cité Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Martel
authors.forename: Patrick
authors.initials: P
authors.lastname: Dutar
authors.forename: Jacques
authors.initials: J
authors.lastname: Epelbaum
authors.forename: Cécile
authors.initials: C
authors.lastname: Viollet