title: Effect of HP-β-cyclodextrin in the diffusion behaviour of hydrocortisone in aqueous solutions at T=298.15 K.
abstract: Binary (D) and ternary (D(11), D(22), D(12) and D(21)) mutual diffusion coefficients determined by the Taylor dispersion method are reported for two aqueous systems, pure hydrocortisone (HC/H(2)O) and HC plus HP-β-cyclodextrin (HC/HP-βCD/H(2)O), at T=298.15 K. From these data, some thermodynamic information as well as conclusions about the influence of that carbohydrate in the diffusion of this drug are given.
authors.affiliation: Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal. anacfrib@ci.uc.pt
authors.forename: Ana C F
authors.initials: AC
authors.lastname: Ribeiro
authors.forename: Luís M P
authors.initials: LM
authors.lastname: Veríssimo
authors.forename: Cecilia I A V
authors.initials: CI
authors.lastname: Santos
authors.forename: Ana M T D P V
authors.initials: AM
authors.lastname: Cabral
authors.forename: Francisco J B
authors.initials: FJ
authors.lastname: Veiga
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Esteso
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D004058:Diffusion; D005079:Excipients / Q000737:chemistry*; D006854:Hydrocortisone / Q000737:chemistry*; D013816:Thermodynamics; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D005079:Excipients; D047392:beta-Cyclodextrins; D014867:Water; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D006854:Hydrocortisone