title: Effects of subchronic exposure to atrazine on zebrafish (Danio rerio).
abstract: The aim of this study was to investigate the effects of subchronic exposure to atrazine on fish growth and the development of histopathological changes in selected organs (gill, kidney, liver) in Danio rerio. Juvenile growth tests were performed on D. rerio according to OECD method No. 215. For 28 days, fish at an initial age of 30 days were exposed to the environmental atrazine concentration commonly detected in Czech rivers (0.3 microg/L) and a range of sublethal concentrations of atrazine (3.0, 30.0 and 90.0 microg/L). The results showed decreasing growth rates and morphological changes in the liver (dystrophic lesions of hepatocytes) at 90.0 microg/L of atrazine. The environmental concentration of atrazine in Czech rivers did not have any effect on fish growth and development of histopathological changes in D. rerio. The value of NOEC was 30.0 microg/L and the value of LOEC was 90.0 microg/L.
authors.affiliation: Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1/3, 612 42 Brno, Czech Republic. lplhalova@vfu.cz
authors.forename: L
authors.initials: L
authors.lastname: Plhalova
authors.forename: J
authors.initials: J
authors.lastname: Blahova
authors.forename: I
authors.initials: I
authors.lastname: Mikulikova
authors.forename: S
authors.initials: S
authors.lastname: Stepanova
authors.forename: P
authors.initials: P
authors.lastname: Dolezelova
authors.forename: E
authors.initials: E
authors.lastname: Praskoval
authors.forename: P
authors.initials: P
authors.lastname: Marsalek
authors.forename: M
authors.initials: M
authors.lastname: Skoric
authors.forename: V
authors.initials: V
authors.lastname: Pistekova
authors.forename: I
authors.initials: I
authors.lastname: Bedanova
authors.forename: Z
authors.initials: Z
authors.lastname: Svobodova
mesh_terms: D000818:Animals; D001280:Atrazine / Q000633:toxicity*; D001522:Behavior, Animal; D018153:Czech Republic; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005880:Gills / Q000187:drug effects; D006540:Herbicides / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D045483:Rivers / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000633:toxicity; D015027:Zebrafish / Q000254:growth & development*
chemical_list: D006540:Herbicides; D014874:Water Pollutants, Chemical; D001280:Atrazine