title: Dynamic changes in the transcriptional profile of subventricular zone-derived postnatally born neuroblasts.
abstract: The subventricular zone (SVZ) of the lateral ventricles is a major neurogenic region in the postnatal mammalian brain. Thousands of neuroblasts are generated daily throughout the life of an animal. Newly born neuroblasts migrate via the rostral migratory stream (RMS) into the olfactory bulb where they mature into distinct neuronal subtypes. Neuroblasts exiting the SVZ retain the ability to proliferate, however, proliferation declines in the course of migration to the olfactory bulb. While migrating in the RMS, neuroblasts receive a plethora of stimuli that modify transcription according to the local microenvironment, and eventually modulate neuroblast migration. In the target area, the olfactory bulb, neuroblasts develop into mature neurons. In this review, we discuss dynamic changes of the transcriptome that occur during the "lifetime" of a neuroblast, thereby governing the activation or inhibition of distinct genes/pathways that are responsible for proliferation, migration and differentiation.
authors.affiliation: Department of Clinical Neurobiology/A230, Heidelberg University Hospital at DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. k.khodosevich@dkfz-heidelberg.de
authors.forename: Konstantin
authors.initials: K
authors.lastname: Khodosevich
authors.forename: Julieta
authors.initials: J
authors.lastname: Alfonso
authors.forename: Hannah
authors.initials: H
authors.lastname: Monyer
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D018507:Gene Expression Regulation, Developmental; D020547:Lateral Ventricles / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism*; D055495:Neurogenesis / Q000235:genetics; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D009830:Olfactory Bulb / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D009419:Nerve Tissue Proteins