title: [Early detection of possibilities for preeclampsia using VEGF1 and other serum analysis].
abstract: BACKGROUND
  The aim of our study is to establish an interaction between serum VEGF1 levels and possibilities of early detection of preeclampsia.
  
  
  METHODS
  For a period of three months we follow up 17 patients with preeclampsia in second trimester by measuring serum levels of VEGF1, PIGF and Inhibin A. A correlation between them was determined.
  
  
  RESULTS
  During our study we investigate 17 patients with preeclampsia and 35 as a control group. Significant differences between serum levels in too groups were established. Serum levels for VEGF1 above 158.5 pg/ml; Inhibin A above 98.50 ng/ml; PIGF levels above 30.01 pg/ml shows a diagnostic sensitivity 88.895 and diagnostic specificity 97.06% in prediction of preeclampsia.
  
  
  CONCLUSIONS
  Measurement of serum VEGF1, PIGF and Inhibin A levels are suitable for early prediction of possibilities for preeclampsia in second trimester. These results are the basis for further studies in this field.
authors.forename: V
authors.initials: V
authors.lastname: Manolov
authors.forename: B
authors.initials: B
authors.lastname: Marinov
authors.forename: V
authors.initials: V
authors.lastname: Vasilev
mesh_terms: D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007265:Inhibins / Q000097:blood; D008565:Membrane Proteins / Q000097:blood; D008958:Models, Molecular; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D008565:Membrane Proteins; C098069:PIGF protein, human; D042461:Vascular Endothelial Growth Factor A; C422362:inhibin A; D007265:Inhibins