title: [Comparative study of Hedysari Radix and Astragali Radix alternative classic tonification prescriptions on humoral immunity in immunosuppressed mice].
abstract: OBJECTIVE
  To compare the regulating effects of Hedysari Radix and Astragali Radix alternative classic tonification prescriptions on humoral immunity in immunosuppressed mice.
  
  
  METHODS
  The immunosuppressed mouse model was induced by cyclophosphamide. The mice were administered intragastically with same dose of Hedysari Radix and Astragali Radix alternative Buzhong Yiqi Yiqi Yangxue,Yupingfeng oral liquid and Fuqi Zhihan granules for antagonistic experiments in vivo. And spleen index, HC50, CD19+B lymphocyte subgroup and content of serum IL-4 were determined after treatment.
  
  
  RESULTS
  Both groups of Hedyseri Radix and Astragali Radix could antagonize immunosuppressive action caused by cyclophosphamide. They both could significantly raise spleen index, HC50, CD19+ B lymphocyte subgroup and content of serum IL4 in different degree. And Yupingfeng aqueous extract of Hedysari Radix substitute Astragali Radix was better than Yupingfeng oral liquid in raising spleen index. There were no significant differences among the rest Hedysari Radix and Astragali Radix alternative groups.
  
  
  CONCLUSIONS
  Hedysari Radix compatibility with other drugs compared with original prescription has similar role in humoral immunity regulation.
authors.affiliation: Institute of Integrated Chinese and Western Medicine, Lanzhou University Lanzhou, Lanzhou, 730000, China. weidongfeng888@yahoo.cn
authors.forename: Dong-Feng
authors.initials: DF
authors.lastname: Wei
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Zhang
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Cheng
authors.forename: Man-Man
authors.initials: MM
authors.lastname: Gui
authors.forename: Xue-Yan
authors.initials: XY
authors.lastname: Li
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Wei
authors.forename: Ying-Cun
authors.initials: YC
authors.lastname: Bao
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D018941:Antigens, CD19 / Q000187:drug effects / Q000276:immunology; D027883:Astragalus Plant / Q000737:chemistry; D002452:Cell Count; D003520:Cyclophosphamide / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry; D005260:Female; D056724:Immunity, Humoral / Q000187:drug effects*; D016867:Immunocompromised Host; D015847:Interleukin-4 / Q000097:blood; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000187:drug effects / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D018941:Antigens, CD19; D004365:Drugs, Chinese Herbal; D015847:Interleukin-4; D003520:Cyclophosphamide