title: Is SCUBE 1 a new biomarker for gastric cancer?
abstract: OBJECTIVE
  This study was intended to determine the diagnostic significance of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE 1) levels in gastric cancer.
  
  
  METHODS
  This retrospective study was conducted with patients with gastric cancer. SCUBE 1 titers of plasma in patients with gastric cancer were determined using an enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  SCUBE 1 titers of gastric cancer patients were significantly higher compared with the control group (P=0.0001). At a SCUBE 1 cut-off point of 43 ng/mL, sensitivity was 67%, specificity 91%, positive predictive values (PPV) 92% and negative predictive values(NPV) 63%. SCUBE 1 levels of patients with methastase were not different from patients without methastase (P> 0.05). DICUSSIONS: SCUBE 1 levels in patients with gastric cancer were found higher compared to healthy subjects.
authors.affiliation: Medical Laboratory Program, Karadeniz Technical University, Vocational School of Health Sciences, Trabzon, Turkey. amentese28@gmail.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Mentese
authors.forename: Evren
authors.initials: E
authors.lastname: Fidan
authors.forename: Aysegül Uzun
authors.initials: AU
authors.lastname: Sumer
authors.forename: Süleyman Caner
authors.initials: SC
authors.lastname: Karahan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sonmez
authors.forename: Diler Us
authors.initials: DU
authors.lastname: Altay
authors.forename: Halil
authors.initials: H
authors.lastname: Kavgaci
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alver
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000556:secondary; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002135:Calcium-Binding Proteins; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000097:blood* / Q000556:secondary
chemical_list: D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D008565:Membrane Proteins; C469998:SCUBE1 protein, human