title: Calcifications associated with pediatric intracranial arterial aneurysms: incidence and correlation with pathogenetic subtypes.
abstract: OBJECTIVE
  Little is known about calcifications associated with pediatric intracranial arterial aneurysms (IAA). We sought to characterize calcifications associated with pediatric IAA according to aneurysm pathogenetic subtype.
  
  
  METHODS
  Patients with IAA less than 20 years of age were retrospectively identified. Three fellowship-trained neuroradiologists independently reviewed each patient's CT studies for calcifications of the parent artery or aneurysm. Aneurysmal calcification (ANC) was correlated with characteristics of the patient (age, sex) and aneurysm pathogenetic subtype, size, morphology, rupture status, and location.
  
  
  RESULTS
  Thirty-three patients (mean age 10 years) with 43 IAA were analyzed. There were no parent artery calcifications. Nine IAA were calcified. IAA in children with non-hemodynamic risk factors (arteriopathy, trauma, infection, tumor) were more commonly calcified than idiopathic IAA (p = 0.029). More than one third of the pediatric IAAs in this group (arteriopathy, infection trauma, tumor) were calcified. IAA ≥ 10 mm were more likely to be calcified (p = 0.03). IAA that were ruptured at presentation were less likely to be calcified (p = 0.03). ANC was not significantly associated with patient age (≤10 years vs. >10 years), sex, morphology (fusiform vs. saccular) or location (anterior vs. posterior circulation).
  
  
  CONCLUSIONS
  Aneurysmal but not parent artery calcifications are associated with a significant minority of pediatric IAA. Pediatric ANCs are associated with underlying non-hemodynamic vascular risk factors (arteriopathy, infection, trauma, and tumor), size ≥10 mm and non-hemorrhagic presentation.
authors.affiliation: University of Cincinnati College of Medicine, Cincinnati, OH, USA. kobrien9@alumni.nd.edu
authors.forename: K
authors.initials: K
authors.lastname: O'Brien
authors.forename: J
authors.initials: J
authors.lastname: Leach
authors.forename: B
authors.initials: B
authors.lastname: Jones
authors.forename: J
authors.initials: J
authors.lastname: Bissler
authors.forename: M
authors.initials: M
authors.lastname: Zuccarello
authors.forename: T
authors.initials: T
authors.lastname: Abruzzo
mesh_terms: D000293:Adolescent; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000453:epidemiology*; D008297:Male; D011859:Radiography; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult