title: [Common pathogens and clinical characteristics of neonatal pneumonia].
abstract: OBJECTIVE
  To study common pathogens and their antibiotic susceptibility as well as clinical characteristics of neonatal pneumonia.
  
  
  METHODS
  A retrospective study on neonatal pneumonia was performed. The study investigated antibiotic susceptibility of four common pathogens (339 strains) that caused neonatal pneumonia. Clinical characteristics of the newborns with pneumonia were analyzed. Of the 339 strains, 185 were isolated from bronchial secretions, 72 from blood samples, and 82 with positive results of both samples.
  
  
  RESULTS
  Four hundred and seventy-four neonates with pneumonia presented positive results of bacterial culture. the most common pathogens Staphylococcus aureus (21.9%), Escherichia coli (19.2%), Klebsiella pneumoniae (19.0%) and Enterobacter cloacae (11.4%). The birth weight of newborns infected with Staphylococcus aureus was generally normal, and the time of hospital admission was later (after 24 hours of life). In contrast, the newborns with gram-negative bacterial infection, especially Klebsiella pneumoniae infection, had lower birth weights and early time of hospital admission (within 24 hours of life). Nearly more than 50% gram-negative bacteria were resistant to second, third and forth generation cephaloporins.
  
  
  CONCLUSIONS
  Gram-negative bacteria are predominant pathogens of neonatal pneumonia. Neonatal pneumonia caused by gram-negative bacteria is common in newborns with low birth weight and its onset time is relatively earlier. Gram-negative bacteria that cause neonatal pneumonia are highly resistant to cephaloporins.
authors.affiliation: Department of Laboratory Medicine, Sichuan University, Chengdu, China.
authors.forename: Hai-Juan
authors.initials: HJ
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Shi
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Zheng-Qiang
authors.initials: ZQ
authors.lastname: Hu
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Mu
authors.forename: Min
authors.initials: M
authors.lastname: Su
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Jiang
mesh_terms: D000328:Adult; D001724:Birth Weight; D024881:Drug Resistance, Bacterial; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D008826:Microbial Sensitivity Tests; D011014:Pneumonia / Q000382:microbiology*; D012189:Retrospective Studies