title: Quantitative estimation of mechanical and optical properties from ultrasound assisted optical tomography data.
abstract: We demonstrate quantitative optical property and elastic property imaging from ultrasound assisted optical tomography data. The measurements, which are modulation depth M and phase ϕ of the speckle pattern, are shown to be sensitively dependent on these properties of the object in the insonified focal region of the ultrasound (US) transducer. We demonstrate that Young's modulus (E) can be recovered from the resonance observed in M versus ω (the US frequency) plots and optical absorption (μ(a)) and scattering (μ(s)) coefficients from the measured differential phase changes. All experimental observations are verified also using Monte Carlo simulations.
authors.affiliation: Department of Physics, Indian Institute of Science, Bangalore 560012, India.
authors.forename: Mayanglambam Suheshkumar
authors.initials: MS
authors.lastname: Singh
authors.forename: Kanhirodan
authors.initials: K
authors.lastname: Rajan
authors.forename: Ram Mohan
authors.initials: RM
authors.lastname: Vasu
authors.forename: Debasish
authors.initials: D
authors.lastname: Roy
mesh_terms: D000042:Absorption; D003198:Computer Simulation; D055119:Elastic Modulus; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*