title: [The levels of serum cystatin C in patients with tumors and healthy controls].
abstract: OBJECTIVE
  To determine the association between serum cystatin C and tumors.
  
  
  METHODS
  Serum samples were obtained from 273 patients with tumors and 185 healthy volunteers. Serum cystatin C was determined by particle-enhanced turbidimetric immunoassay (PETIA). Student t-test, covariance analysis and multiple linear regressions were performed to examine the differences in the levels of cystatin C between the two groups.
  
  
  RESULTS
  The student t-test did not show significant statistical differences in the serum cystatin C levels between the two groups (P = 0.075). However, such differences became statistically significant (P < 0.01) after adjustment of age. The multiple liner regression demonstrated that healthy volunteers and men had higher levels of cystatin C than those with tumors and women. Cystatin C also increased with age and decreases with estimating glomerular filtration rate.
  
  
  CONCLUSIONS
  Cystatin C may be associated with the genesis and development of tumors.
authors.affiliation: Department of Clinical Biochemistry of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Hao-Lan
authors.initials: HL
authors.lastname: Song
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Cheng-Yao
authors.initials: CY
authors.lastname: Jia
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D055316:Cystatin C / Q000097:blood*; D015853:Cysteine Proteinase Inhibitors / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000503:physiopathology
chemical_list: D055316:Cystatin C; D015853:Cysteine Proteinase Inhibitors