title: Biometric measurements in highly myopic eyes.
abstract: OBJECTIVE
  To assess the repeatability and accuracy of optical biometry (Lenstar LS900 optical low-coherence reflectometry [OLCR] and IOLMaster partial coherence interferometry [PCI]) and applanation ultrasound biometry in highly myopic eyes.
  
  
  METHODS
  Division of Preventive Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China.
  
  
  METHODS
  Comparative evaluation of diagnostic technology.
  
  
  METHODS
  Biometric measurements were taken in highly myopic subjects with a spherical equivalent (SE) of -6.00 diopters (D) or higher and an axial length (AL) longer than 25.0 mm. Measurements of AL and anterior chamber depth (ACD) obtained by OLCR were compared with those obtained by PCI and applanation A-scan ultrasound. Right eyes were analyzed. Repeatability was evaluated using the coefficient of variation (CoV) and agreement, using Bland-Altman analyses.
  
  
  RESULTS
  The mean SE was -11.20 D ± 4.65 (SD). The CoVs for repeated AL measurements using OLCR, PCI, and applanation ultrasound were 0.06%, 0.07%, and 0.20%, respectively. The limits of agreement (LoA) for AL were 0.11 mm between OLCR and PCI, 1.01 mm between OLCR and applanation ultrasound, and 1.03 mm between PCI and ultrasound. The ACD values were 0.29 mm, 0.53 mm, and 0.51 mm, respectively. These repeatability and agreement results were comparable in eyes with extreme myopia (AL ≥ 27.0 mm) or posterior staphyloma. The mean radius of corneal curvature was similar between OLCR and PCI (7.66 ± 0.24 mm versus 7.64 ± 0.25 mm), with an LoA of 0.12 mm.
  
  
  CONCLUSIONS
  Optical biometry provided more repeatable and precise measurements of biometric parameters, including AL and ACD, than applanation ultrasound biometry in highly myopic eyes.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
authors.forename: Peiyang
authors.initials: P
authors.lastname: Shen
authors.forename: Yingfeng
authors.initials: Y
authors.lastname: Zheng
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Ding
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Nathan
authors.initials: N
authors.lastname: Congdon
authors.forename: Ian
authors.initials: I
authors.lastname: Morgan
authors.forename: Mingguang
authors.initials: M
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000867:Anterior Chamber / Q000473:pathology*; D058452:Axial Length, Eye / Q000473:pathology*; D001699:Biometry / Q000295:instrumentation*; D002648:Child; D003315:Cornea / Q000473:pathology; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000175:diagnosis*; D012029:Refraction, Ocular / Q000502:physiology; D015203:Reproducibility of Results; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult