title: The role of the proto-oncogene c-myc in B lymphocyte differentiation.
abstract: Since the discovery of the myc gene, few genes are likely to have such influence on biomedical research. The diversity of the biological functions regulated by this transcription factor and its impact in human health have attracted investigators from many different fields. The development of conditional knockout mouse models has allowed for the characterization of Myc-driven molecular mechanisms in primary cells in physiological and pathological conditions. In this review, we discuss some of the main functions and recent findings regarding c-Myc in in vivo B lymphocyte differentiation from early progenitors to terminally differentiated cells.
authors.affiliation: Department of Immunology and Oncology, National Center for Biotechnology CNB/CSIC, Madrid, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Fernandez
authors.forename: Victor Javier
authors.initials: VJ
authors.lastname: Sanchez-Arevalo
authors.forename: Ignacio Moreno
authors.initials: IM
authors.lastname: de Alboran
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism*; D002454:Cell Differentiation; D006801:Humans; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc