title: The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues.
abstract: Mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) is not included in the traditional textbook schemes of the respiratory chain, reflecting the fact that it is a non-standard, tissue-specific component of mammalian mitochondria. But despite its very simple structure, mGPDH is a very important enzyme of intermediary metabolism and as a component of glycerophosphate shuttle it functions at the crossroads of glycolysis, oxidative phosphorylation and fatty acid metabolism. In this review we summarize the present knowledge on the structure and regulation of mGPDH and discuss its metabolic functions, reactive oxygen species production and tissue and organ specific roles in mammalian mitochondria at physiological and pathological conditions.
authors.affiliation: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Mráček
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Drahota
authors.forename: Josef
authors.initials: J
authors.lastname: Houštěk
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000235:genetics / Q000502:physiology*; D006019:Glycolysis; D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D009928:Organ Specificity; D010085:Oxidative Phosphorylation; D017382:Reactive Oxygen Species / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D017382:Reactive Oxygen Species; D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase