title: [Adenocarcinoma of the stomach and neuroendocrine carcinoma of the colon in a 45-year-old male patient suffering from common variable immunodeficiency (CVID) and ulcerative colitis].
abstract: Common variable immunodeficiency (CVID) is the most common primary antibody deficient syndrome in adults. Among the broad spectrum of clinical manifestations are recurrent infections, allergies, autoimmune, tumour, pulmonary, liver and gastrointestinal diseases. Here we report the case of a 45-year-old male patient, who has been suffering from ulcerative colitis - likewise recognised as a CVID-associated disease - for many years. He was admitted to our clinic with a rapid progressive reduction of his general condition and a loss of weight. Diagnostic work-up revealed adenocarcinoma of the stomach as well as an undifferentiated neuroendocrine carinoma of the colorectum at the rectosigmoidal junction. Curative resection of the distal stomach and proctolcolectomy were performed. To date, the pathogenesis of the association of many diseases with CVID is still ambiguous. Yet, there is no doubt about the significantly higher incidence of e.g., inflammatory bowel disease or gastric cancer in patients with CVID. Our case highlights that in patients with CVID and obscure deterioration of their general health condition a careful search for especially malignant complications is mandatory although to date there are no precise recommendations for screening.
authors.affiliation: Klinik für Gastroenterologie, Hepatologie und Gastroenterologische Onkologie, Klinikum Bogenhausen, Städtisches Klinikum München GmbH, Akademisches Lehrkrankenhaus der TU München, München. max.gemeinhardt@gmx.de
authors.forename: M
authors.initials: M
authors.lastname: Gemeinhardt
authors.forename: J
authors.initials: J
authors.lastname: Türck
authors.forename: B
authors.initials: B
authors.lastname: Piper
authors.forename: T
authors.initials: T
authors.lastname: Helmberger
authors.forename: A
authors.initials: A
authors.lastname: Nerlich
authors.forename: W
authors.initials: W
authors.lastname: Schepp
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000601:surgery; D003093:Colitis, Ulcerative; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D017074:Common Variable Immunodeficiency / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000601:surgery; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000601:surgery; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000601:surgery; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000601:surgery