title: [Neuroprotective and antiamnesic effects of GK-2h dipeptide HNGF mimetic on a model of experimental ischemic stroke of brain cortex prefrontal areas].
abstract: Neuroprotective and antiamnesic effects of human nerve growth factor (HNGF) synthetic dipeptide mimetic bis-(N-monosuccinyl-glycyl-lysine)hexamethylenediamide (GK-2h) has been studied on a model of bilateral photochemically induced focal ischemical brain injury in prefrontal cortex of rats. It is established that a single intraperitoneal injection of GK-2h (0.1 mg/kg) 1 h or 4 h after operation, followed by injections on the 2nd, 4th and 8th days after operation, results (on the 9th day) in reduction of the cortical infarction volume by 47 or 65%, and leads to restoration of the passive avoidance reflex (acquired before experimental ischemic insult) by 42 and 60%, respectively. It is concluded that GK-2h possesses significant neuroprotective properties.
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: G A
authors.initials: GA
authors.lastname: Romanova
authors.forename: F M
authors.initials: FM
authors.lastname: Shakova
authors.forename: S O
authors.initials: SO
authors.lastname: Kotel'nikova
authors.forename: I V
authors.initials: IV
authors.lastname: Barskov
authors.forename: E V
authors.initials: EV
authors.lastname: Stel'mashuk
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008297:Male; D020932:Nerve Growth Factor / Q000737:chemistry / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D057786:Peptidomimetics / Q000737:chemistry / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D020521:Stroke / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology
chemical_list: D004151:Dipeptides; D018696:Neuroprotective Agents; D057786:Peptidomimetics; C572946:bis(N-succinyl-glutamyllysin)hexamethylenediamine; D020932:Nerve Growth Factor