title: Rhodium-catalyzed enantioselective addition to unsymmetrical α-diketones: tandem one-pot synthesis of optically active 3-tetrasubstituted isochroman derivatives.
abstract: The domino effect: An efficient and general catalytic one-pot synthesis of quaternary-substituted isochroman derivatives has been developed (see scheme). The cascade transformation relies on rhodium-catalyzed highly regio- and enantioselective 1,2-addition of arylboronic acids to unsymmetrical α-diketones and intramolecular etherification or esterification, and provides a variety of enantioenriched isochromanones under exceptionally mild conditions.
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.
authors.forename: Ting-Shun
authors.initials: TS
authors.lastname: Zhu
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Chen
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Xu
mesh_terms: D002384:Catalysis; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D055620:Optical Phenomena; D009942:Organometallic Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002867:Chromones; D007659:Ketones; D009942:Organometallic Compounds; D012238:Rhodium