title: Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge Placospongia sp.
abstract: Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPARδ) with an EC(50) of 23.7 nM.
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Korea.
authors.forename: Hiyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Jungwook
authors.initials: J
authors.lastname: Chin
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.forename: Kyungryul
authors.initials: K
authors.lastname: Baek
authors.forename: Tae-Gu
authors.initials: TG
authors.lastname: Lee
authors.forename: Seong Eon
authors.initials: SE
authors.lastname: Park
authors.forename: Weihong
authors.initials: W
authors.lastname: Wang
authors.forename: Dongyup
authors.initials: D
authors.lastname: Hahn
authors.forename: Inho
authors.initials: I
authors.lastname: Yang
authors.forename: Jihye
authors.initials: J
authors.lastname: Lee
authors.forename: Bora
authors.initials: B
authors.lastname: Mun
authors.forename: Merrick
authors.initials: M
authors.lastname: Ekins
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006847:Hydrocarbons, Iodinated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007723:Korea; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047494:PPAR delta / Q000819:agonists*; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
chemical_list: D006847:Hydrocarbons, Iodinated; D009943:Organophosphorus Compounds; D047494:PPAR delta; C581059:phosphoiodyn A; C581060:phosphoiodyn B; D053279:Polyynes