title: What lessons can be learned from γδ T cell-based cancer immunotherapy trials?
abstract: During the last several years, research has produced a significant amount of knowledge concerning the characteristics of human γδ T lymphocytes. Findings regarding the immune functions of these cells, particularly their natural killer cell-like lytic activity against tumor cells, have raised expectations for the therapeutic applications of these cells for cancer. Pharmaceutical companies have produced selective agonists for these lymphocytes, and several teams have launched clinical trials of γδ T cell-based cancer therapies. The findings from these studies include hematological malignancies (follicular lymphoma, multiple myeloma, acute and chronic myeloid leukemia), as well as solid tumors (renal cell, breast and prostate carcinomas), consisting of samples from more than 250 patients from Europe, Japan and the United States. The results of these pioneering studies are now available, and this short review summarizes the lessons learned and the role of γδ T cell-based strategies in the current landscape of cancer immunotherapies.
authors.affiliation: INSERM UMR1037-Cancer Research Center of Toulouse, Toulouse, France. jean-jacques.fournie@inserm.fr
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Fournié
authors.forename: Hélène
authors.initials: H
authors.lastname: Sicard
authors.forename: Mary
authors.initials: M
authors.lastname: Poupot
authors.forename: Christine
authors.initials: C
authors.lastname: Bezombes
authors.forename: Amandine
authors.initials: A
authors.lastname: Blanc
authors.forename: François
authors.initials: F
authors.lastname: Romagné
authors.forename: Loic
authors.initials: L
authors.lastname: Ysebaert
authors.forename: Guy
authors.initials: G
authors.lastname: Laurent
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta