title: Nonequilibrium gating of CFTR on an equilibrium theme.
abstract: Malfunction of cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ABC protein superfamily that functions as an ATP-gated chloride channel, causes the lethal genetic disease, cystic fibrosis. This review focuses on the most recent findings on the gating mechanism of CFTR. Potential clinical relevance and implications to ABC transporter function are also discussed.
authors.affiliation: Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri, USA.
authors.forename: Kang-Yang
authors.initials: KY
authors.lastname: Jih
authors.forename: Tzyh-Chang
authors.initials: TC
authors.lastname: Hwang
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D018118:Chloride Channels / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000378:metabolism / Q000503:physiopathology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism*; D015640:Ion Channel Gating / Q000502:physiology*
chemical_list: D018528:ATP-Binding Cassette Transporters; D018118:Chloride Channels; D019005:Cystic Fibrosis Transmembrane Conductance Regulator