title: Characterization of two polymorphs of lornoxicam.
abstract: OBJECTIVE
  The aim of the study was to prepare and to characterize two polymorphs of lornoxicam, a water-insoluble non-steroidal anti-inflammatory drug, which has thus far received no exploration of its polymorphs.
  
  
  METHODS
  Form I and form II of lornoxicam were prepared by recrystallization and characterized by X-ray powder diffractometry (XRPD), thermal analysis, Fourier transform infrared spectroscopy and scanning electron microscopy. The solubility and dissolution of both polymorphs were also determined and compared to provide the basis for polymorph selection in formulation.
  
  
  RESULTS
  The crystal structures of the two polymorphs were established by the experimental XRPD patterns. Form I was demonstrated to be triclinic with two kinds of intermolecular hydrogen bonds, while form II was orthorhombic with two kinds of intramolecular hydrogen bonds. The morphologies of form I and form II were observed to be rectangle and approximately oval, respectively.
  
  
  CONCLUSIONS
  Form II had the significantly higher solubility and dissolution and would be the suitable polymorph for the preparation of oral and injectable dosage forms of lornoxicam.
authors.affiliation: Department of Pharmaceutics, China Pharmaceutical University Nanjing, Nanjing, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Tan
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.forename: Weiming
authors.initials: W
authors.lastname: Fan
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Shuai
authors.initials: S
authors.lastname: Qian
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004058:Diffusion; D006860:Hydrogen Bonding; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D033362:Powder Diffraction; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D013818:Thermogravimetry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; C059451:lornoxicam