title: Is hyperinsulinemia required to develop overeating-induced obesity?
abstract: Type 2 diabetes is characterized by insulin resistance, and the hyperinsulinemia commonly observed in patients is thought to be a compensatory response. Yet it has been difficult to disentangle cause and effect. Mehran et al. (2012) provide genetic evidence that a reduction of insulin secretion prevents high-fat feeding-induced obesity.
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA. christoph.buettner@mssm.edu
authors.forename: Christoph
authors.initials: C
authors.lastname: Buettner