title: Assessment of serum KL-6 as a prognostic marker in pulmonary tuberculosis patients.
abstract: Although serum Krebs von den Lungen-6 (KL-6) levels are reported to increase in pulmonary tuberculosis (PTB) patients according to disease activity, the relationship between serum KL-6 levels and prognosis remains unclear. In this study, we prospectively examined serum KL-6 levels in  188 PTB patients and assessed 60-day mortality. Univariate and multivariate logistic regression analysis demonstrated that serum KL-6 levels were not significantly associated with prognosis. For receiver operating characteristic analysis, the area under the curve had low accuracy for predicting  mortality. These findings indicate that serum KL-6 levels do not perform adequately for use as a prognostic marker in patients with PTB.
authors.affiliation: Department of Respiratory Medicine, Tenryu Hospital, National Hospital Organization, Hamamatsu, Japan. miwamaro11@yahoo
authors.forename: S
authors.initials: S
authors.lastname: Miwa
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Shirai
authors.forename: H
authors.initials: H
authors.lastname: Ohba
authors.forename: M
authors.initials: M
authors.lastname: Kanai
authors.forename: T
authors.initials: T
authors.lastname: Eifuku
authors.forename: T
authors.initials: T
authors.lastname: Suda
authors.forename: H
authors.initials: H
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Chida
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D018396:Mucin-1 / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D014397:Tuberculosis, Pulmonary / Q000097:blood*
chemical_list: D015415:Biomarkers; C060192:MUC1 protein, human; D018396:Mucin-1