title: HSP90 inhibitor antagonizing MIF:  The specifics of pleiotropic cancer drug candidates.
abstract: Constitutively stabilized HSP90 client proteins are crucial for cancer cell survival and proliferation. Thus, despite-or perhaps because of-their pleiotropic effects on variety of critical oncoproteins, HSP90 inhibitors represent a promising new class of anticancer drugs. We identified MIF as an essential HSP90 client protein in a murine model of Her2-overexpressing breast cancer.
authors.affiliation: Department of Molecular Oncology; Göttingen Center of Molecular Biosciences; University of Göttingen; Göttingen, Germany.
authors.forename: Ramona
authors.initials: R
authors.lastname: Schulz
authors.forename: Matthias
authors.initials: M
authors.lastname: Dobbelstein
authors.forename: Ute M
authors.initials: UM
authors.lastname: Moll