title: The role of calcium stores in apoptosis and autophagy.
abstract: The mechanisms that regulate programmed cell death, such as apoptosis, and the cellular "self-eating" phenomenon of autophagy, share many regulatory systems and common pathways. These mechanisms have been extensively investigated over the last few years. Some intracellular structures may determine and control the autophagic fate of the cell such as the endoplasmic reticulum, mitochondria, and lysosomes. The coordination and interrelation of these organelles are crucial in maintaining calcium levels and general cellular homeostasis, as well as in regulating cell life and death under physiological and pathological conditions, including cancer, neurodegeneration, and aging. In this review, we discuss the crosstalk between the aforementioned organelles and their influence in apoptotic and autophagic processes.
authors.affiliation: Department of Pharmacology, Paulista School of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. ssmaili@unifesp.br
authors.forename: S S
authors.initials: SS
authors.lastname: Smaili
authors.forename: G J S
authors.initials: GJ
authors.lastname: Pereira
authors.forename: M M
authors.initials: MM
authors.lastname: Costa
authors.forename: K K
authors.initials: KK
authors.lastname: Rocha
authors.forename: L
authors.initials: L
authors.lastname: Rodrigues
authors.forename: L G
authors.initials: LG
authors.lastname: do Carmo
authors.forename: H
authors.initials: H
authors.lastname: Hirata
authors.forename: Y-T
authors.initials: YT
authors.lastname: Hsu
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D001343:Autophagy / Q000235:genetics; D002118:Calcium / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D008247:Lysosomes / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: D002118:Calcium