title: Case report of interstitial nephritis induced by bevacizumab therapy for glioblastoma multiforme.
abstract: Glioblastoma multiforme is an aggressive malignant brain tumor. The monoclonal antibody, bevacizumab, is active in recurrent disease via inhibition of angiogenesis. Proteinuria and renal thrombotic microangiopathy are known complications. We report a case of a patient developing acute renal failure with biopsy-proven interstitial nephritis while receiving bevacizumab for recurrent disease. The patient was otherwise well with a history of controlled hypertension. Renal function improved with discontinuation of bevacizumab and the administration of corticosteroid therapy.
authors.affiliation: Royal Melbourne Hospital, Australia.
authors.forename: Anna J
authors.initials: AJ
authors.lastname: Lomax
authors.forename: Prue A
authors.initials: PA
authors.lastname: Hill
authors.forename: David M
authors.initials: DM
authors.lastname: Ashley
mesh_terms: D020533:Angiogenesis Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects* / Q000627:therapeutic use; D000068258:Bevacizumab; D001706:Biopsy; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology; D005909:Glioblastoma / Q000188:drug therapy / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D005938:Glucocorticoids; D000068258:Bevacizumab