title: Steroids in bacterial meningitis: yes.
abstract: Bacterial meningitis is an infectious condition associated with severe morbidity and mortality, even with rapid diagnosis and appropriate antibiotic therapy. Despite decrease in the rate of bacterial meningitis brought about by vaccination programs against Haemophilus influenzae type-B and Streptococcus pneumonia, the incidence of meningitis is still unacceptably high and acute treatment remains the mainstay of therapy. The infection is accompanied by intense inflammatory response, which may carry deleterious effects upon the tissue. This led to the possibility of adjuvant corticosteroid therapy, as an anti-inflammatory agent, in bacterial meningitis. The debate focuses on the rational and evidence supporting and refuting such an approach.
authors.affiliation: Department of Neurology, Rabin Medical Center, Campus Beilinson, Petach Tikva, Israel.
authors.forename: Felix
authors.initials: F
authors.lastname: Benninger
authors.forename: Israel
authors.initials: I
authors.lastname: Steiner
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D016920:Meningitis, Bacterial / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D003907:Dexamethasone