title: A BODIPY-based fluorescent dye for mitochondria in living cells, with low cytotoxicity and high photostability.
abstract: A BODIPY-based dye, OBEP, has been developed to act as a mitochondrial fluorescence probe. This dye is of high stability, low toxicity and insensitive in a pH range as wide as pH 2-10. Its uptake into mitochondria is independent of mitochondrial membrane potential in living cells. OBEP can label swollen mitochondria resulting from different degrees of cell damage in light and resist fading even after 12 h of incubation.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian, PR China.
authors.forename: Si
authors.initials: S
authors.lastname: Zhang
authors.forename: Tong
authors.initials: T
authors.lastname: Wu
authors.forename: Jiangli
authors.initials: J
authors.lastname: Fan
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Li
authors.forename: Na
authors.initials: N
authors.lastname: Jiang
authors.forename: Jingyun
authors.initials: J
authors.lastname: Wang
authors.forename: Bairui
authors.initials: B
authors.lastname: Dou
authors.forename: Shiguo
authors.initials: S
authors.lastname: Sun
authors.forename: Fengling
authors.initials: F
authors.lastname: Song
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Peng
mesh_terms: D001692:Biological Transport; D001896:Boron Compounds / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004355:Drug Stability; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D008027:Light; D061986:MCF-7 Cells; D008928:Mitochondria / Q000378:metabolism*; D011758:Pyrroles / Q000737:chemistry
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D011758:Pyrroles