title: Effect of myopia on ganglion cell complex and peripapillary retinal nerve fibre layer measurements: a Fourier-domain optical coherence tomography study of young Chinese persons.
abstract: BACKGROUND
  To investigate the change of the ganglion cell complex and peripapillary retinal nerve fibre layer under different refractive conditions, as measured by optical coherence tomography.
  
  
  METHODS
  Cross-sectional observational study.
  
  
  METHODS
  A total of 107 eyes from 107 subjects were studied.
  
  
  METHODS
  Ganglion cell complex and retinal nerve fibre layer were studied by a spectral-domain system. Their relationship against spherical equivalents and axial length was studied.
  
  
  METHODS
  The thickness of ganglion cell complex and retinal nerve fibre layer at different area and under different refractive conditions as measurements by optical coherence tomography.
  
  
  RESULTS
  The average, superior and inferior macular ganglion cell complex thickness was significantly associated with both spherical equivalents (all P < 0.05) and axial length (all P < 0.05). Peripapillary retinal nerve fibre layer thicknesses from the superior, inferior and temporal quadrants were associated with both spherical equivalents (all P < 0.01), axial length (all P < 0.05) and ganglion cell complex thickness (all P < 0.001), except for the nasal part. However, if the retinal nerve fibre layer thickness was studied in sections, then some parts of the upper and lower temporal part showed no correlation with either spherical equivalents or axial length (all P < 0.05).
  
  
  CONCLUSIONS
  The thicknesses of the ganglion cell complex and most of the peripapillary retinal nerve fibre layer were correlated with refraction and axial length. Therefore, when using these for clinical purposes, attention must be paid to the refractive state of the patient.
authors.affiliation: Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital, School of Shanghai Medicine, Fudan University, Shanghai, China.
authors.forename: Zhennan
authors.initials: Z
authors.lastname: Zhao
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000208:ethnology; D058452:Axial Length, Eye / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D009216:Myopia / Q000208:ethnology / Q000503:physiopathology*; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D055815:Young Adult