title: Measurements of water content in hydroxypropyl-methyl-cellulose based hydrogels via texture analysis.
abstract: In this work, a fast and accurate method to evaluate the water content in a cellulose derivative-based matrix subjected to controlled hydration was proposed and tuned. The method is based on the evaluation of the work of penetration required in the needle compression test. The work of penetration was successfully related to the hydrogel water content, assayed by a gravimetric technique. Moreover, a fitting model was proposed to correlate the two variables (the water content and the work of penetration). The availability of a reliable tool is useful both in the quantification of the water uptake phenomena, both in the management of the testing processes of novel pharmaceutical solid dosage forms.
authors.affiliation: Dipartimento di Ingegneria Industriale, Università di Salerno, Via Ponte don Melillo, Italy. glamberti@unisa.it
authors.forename: Gaetano
authors.initials: G
authors.lastname: Lamberti
authors.forename: Sara
authors.initials: S
authors.lastname: Cascone
authors.forename: Maria Margherita
authors.initials: MM
authors.lastname: Cafaro
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Titomanlio
authors.forename: Matteo
authors.initials: M
authors.lastname: d'Amore
authors.forename: Anna Angela
authors.initials: AA
authors.lastname: Barba
mesh_terms: D020100:Hydrogels / Q000032:analysis / Q000737:chemistry; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D014867:Water / Q000032:analysis / Q000737:chemistry
chemical_list: D020100:Hydrogels; D014867:Water; D065347:Hypromellose Derivatives; D008747:Methylcellulose