title: Extraskeletal osteosarcoma of the pleura:report of a case.
abstract: Extraskeletal osteosarcoma is a rare malignant tumor occurring very rarely in the pleura. We herein report the case of 67-year-old man with asbestos exposure, who underwent biopsies of the large tumor from the chest wall, and diagnosed as a suspicious of fibrosarcoma. Surgical resection was done, and the pathological diagnosis was extraskeletal osteosarcoma arising from the pleura. The differential diagnosis is malignant pleural mesothelioma with osseous and cartilaginous which is also very rare and one of the histopathological subtypes with heterologous elements. Identification of epithelial components, labeling for cytokeratins in spindle cells and its' anatomical distribution may help to distinguish them. In the neoplasm arising from the parietal pleura, primary extraskeletal osteosarcoma of the pleura is very rare, but should be considered.
authors.affiliation: Department of General Thoracic Surgery, Chiba Rosai Hospital, Ichihara, Chiba, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Shiota
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Yasukawa
authors.forename: Ayako
authors.initials: A
authors.lastname: Hirai
authors.forename: Masako
authors.initials: M
authors.lastname: Chiyo
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yusa
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
mesh_terms: D000368:Aged; D001194:Asbestos / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012516:Osteosarcoma / Q000737:chemistry / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D010997:Pleural Neoplasms / Q000737:chemistry / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D001194:Asbestos