title: [Effect of Kang'ai injection on hepatic fibrosis in rats].
abstract: OBJECTIVE
  To investigate the inhibition role of Kang'ai injection (KAI) in rats with hepatic fibrosis.
  
  
  METHODS
  Animal model with liver fibrosis were induced by 0.01% concentration of diethylnitrosamine (DEN). 30 female Wistar rats (160-200 g) were randomly divided into 3 groups: the KAI-DEN group, the DEN group and the blank control group. The KAI-DEN group was administered Kang'ai injection (1 mL x k(-1), intraperitoneal injection, once a week) and the DEN group was administered normal saline intraperitoneal injection. HE staining and VG special staining of liver tissue were used to evaluate liver fibrosis.
  
  
  RESULTS
  Compared with the DEN group, relatively less structural damage and less pseudolobular formation in the KAI-DEN group. Collagen area of the blank control group, the KAI-DEN group and the DEN group were (6.52 +/- 2.64)% , (17.41 +/- 1.112)% and (20.180 +/- 2.519)% , respectively. The difference was statistically significant, P < 0.05.
  
  
  CONCLUSIONS
  Kang'ai injection could inhibit the formation of DEN-induced liver fibrosis.
authors.affiliation: Xinjiang Medical University of Chinese Medicine Hospital, Urumqi 830000, China. 748215562@qq.com
authors.forename: Xinmei
authors.initials: X
authors.lastname: Xie
authors.forename: Rui
authors.initials: R
authors.lastname: Pang
authors.forename: Fanye
authors.initials: F
authors.lastname: Zeng
authors.forename: Hongliang
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal