title: [Free radical processes in the pathogenesis of involutional skin changes].
abstract: OBJECTIVE
  To study the role of free radical processes (FRP) in the development of involutional skin changes and their correction.
  
  
  METHODS
  One hundred and twenty patients aged 18 to 74 years with various degrees of involutional facial and cervical skin changes were examined. Clinical and laboratory assessments were made over time. The oxygen and lipid peroxidase parameters of FRP were estimated; objective and subjective visualization, Doppler flowmetry of the facial skin, and colorimetric study of the skin color spectrum were done.
  
  
  RESULTS
  The imbalance between oxygen and lipid peroxide components of FRP was found to increase with advancing age. These processes correlate with the severity of involutional skin changes and objectify the early use of energy-correcting therapy (ECT). The incorporation of ECT with cytoflavin positively affects FRP values and clinical and instrumental findings of involutional facial and cervical skin changes, by improving microcirculation. The patients with first-second degree involutional skin changes achieved the best results.
  
  
  CONCLUSIONS
  The findings permit cytoflavin to be recommended as one of the components of therapy aimed to stabilize intradermal exchange processes as part cosmetic manipulations in aesthetic medicine.
authors.forename: N E
authors.initials: NE
authors.lastname: Manturova
authors.forename: E V
authors.initials: EV
authors.lastname: Silina
authors.forename: V A
authors.initials: VA
authors.lastname: Stupin
authors.forename: G O
authors.initials: GO
authors.lastname: Smirnova
authors.forename: S B
authors.initials: SB
authors.lastname: Bolevich
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D003124:Colorimetry; D004338:Drug Combinations; D005145:Face / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005486:Flavin Mononucleotide / Q000627:therapeutic use; D005609:Free Radicals / Q000097:blood*; D006801:Humans; D007290:Inosine Diphosphate / Q000627:therapeutic use; D017078:Laser-Doppler Flowmetry; D008054:Lipid Peroxides / Q000097:blood*; D008875:Middle Aged; D009333:Neck / Q000473:pathology / Q000503:physiopathology*; D009536:Niacinamide / Q000627:therapeutic use; D010100:Oxygen / Q000097:blood*; D012720:Severity of Illness Index; D012871:Skin Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013386:Succinates / Q000627:therapeutic use; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D004338:Drug Combinations; D005609:Free Radicals; D008054:Lipid Peroxides; D013386:Succinates; C507879:cytoflavin; D014803:Vitamin B Complex; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D010100:Oxygen