title: Berberine‑attenuated monocyte adhesion to endothelial cells induced             by oxidized low‑density lipoprotein via inhibition of adhesion molecule expression.
abstract: Recruitment of monocytes to endothelial cells is important during early stages of atherosclerosis development. This process is predominantly mediated by cellular adhesion molecules, including vascular cell adhesion molecule‑1 (VCAM‑1) and intercellular adhesion molecule‑1 (ICAM‑1), which are expressed by activated endothelial cells in response to a number of inflammatory stimuli, including oxidized low‑density lipoprotein (oxLDL). Previous studies have demonstrated that berberine, a natural extract from Rhizoma coptidis, prevents oxLDL‑induced endothelial cellular apoptosis. However, its effect on the adhesion of monocytes to endothelial cells and the mechanism associated with this process remains unclear. In the present study, berberine was revealed to markedly reduce oxLDL‑induced monocyte adhesion to human umbilical vein endothelial cells. In addition, the inhibitory mechanism of berberine was associated with suppression of adhesion molecule expression, including VCAM‑1 and ICAM‑1. Results indicate that berberine plays a protective role in the early stages of atherosclerosis.
authors.affiliation: Cardiac Center, The First Affiliated Hospital of Wenzhou Medical                     College, Zhejiang 325000, P.R. China.
authors.forename: Zhouqing
authors.initials: Z
authors.lastname: Huang
authors.forename: Xueli
authors.initials: X
authors.lastname: Cai
authors.forename: Sheng
authors.initials: S
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Zhou
authors.forename: Maoping
authors.initials: M
authors.lastname: Chu
authors.forename: Peiren
authors.initials: P
authors.lastname: Shan
authors.forename: Weijian
authors.initials: W
authors.lastname: Huang
mesh_terms: D001599:Berberine / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D009000:Monocytes / Q000166:cytology / Q000187:drug effects*; D015854:Up-Regulation / Q000187:drug effects; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D008077:Lipoproteins, LDL; D019010:Vascular Cell Adhesion Molecule-1; C099252:oxidized low density lipoprotein; D001599:Berberine; D018799:Intercellular Adhesion Molecule-1