title: [Postsurgical delirium complicated with sepsis. Dexmedetomidine versus midazolam].
abstract: OBJECTIVE
  to determine which drug dexmedetomidine or midazolam produces greater delirium in septic patients.
  
  
  METHODS
  observational, analytical, comparative, prospective and longitudinal in 59 postsurgical patients both sexes, with mechanical ventilation (MV), sepsis, and sedation with dexmedetomidine or midazolam complicated with sepsis was done. We evaluated age, severity of sepsis with SOFA and APACHE. Complications associated with delirium were registered. The "t" Student test and χ(2) were used.
  
  
  RESULTS
  Midazolam group, 33 patients, mean age 49.75 ± 19.48 years, SOFA 15.81 ± 7.48 points and APACHE 7.51 ± 5.41, delirium was present in 29 patients, days of MV 15.86 ± 14.12, reintubation rate 24 %, ICU stay 16.41 ± 14.41, hospital stay 28.58 ± 19.91 days and death rate 34.5 %. Dexmedetomidine group: 26 patients, mean age 49.57 ± 13.76 years, in SOFA 13.34 ± 7.66 points and 6.23 ± 4.51 in APACHE scale, delirium in 11 patients, days of MV 17.9 ± 12.53 and reintubation in 45.5 %, ICU days 14.36 ± 9.25, hospital stay 22.63 ± 14.87 and death in 36.4 %.
  
  
  CONCLUSIONS
  delirium was increased in complicated post-surgical patients with sepsis, mechanical ventilation and midazolam.
authors.affiliation: Unidad de Cuidados Intensivos, Hospital de Especialidades 25, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, Mexico. ac3_adrenalina@hotmail.com
authors.forename: Felipe de Jesús Martín
authors.initials: Fde J
authors.lastname: Pérez-Rada
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Macías-García
authors.forename: Alicia Concepción
authors.initials: AC
authors.lastname: Cataneo-Cerna
mesh_terms: D003693:Delirium / Q000139:chemically induced*; D020927:Dexmedetomidine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D008137:Longitudinal Studies; D008297:Male; D008874:Midazolam / Q000009:adverse effects*; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced*; D011446:Prospective Studies; D018805:Sepsis / Q000150:complications*
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D008874:Midazolam