title: Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth.
abstract: External apical root resorption (EARR) is a frequent iatrogenic problem following orthodontic treatment in endodontically-treated teeth, about which the literature reports substantial variability in post-orthodontic treatment EARR responses. The main focus of the present study is to clarify whether variants in the interleukin-1 receptor antagonist gene coding for the IL-1ra protein have a positive/negative influence on EARR of endodontically-treated teeth. Ninety-three orthodontic patients were genetically screened for a single nucleotide polymorphism (SNP:rs419598) in the IL1 cluster. The sample was classified into 2 groups: group 1 (affected-group) showed radiographic EARR of more than 2mm; group 2 (control-group), had no EARR or EARR ≤ to 2mm following orthodontic treatment on root-filled teeth. Logistic regression analysis was performed to obtain an adjusted estimate between the SNPs studied and EARR. Genotype distributions, allelic frequencies, adjusted odds ratios (OR) and 95% confidence intervals were also calculated. We found that subjects homozygous [1/1(TT)] for the IL1RN gene [OR:10.85; p=0.001;CI:95%] were at risk of EARR in root-filled teeth. Genetic variants in the antagonist axis balance of the IL1RN (rs419598) have a direct repercussion on the predisposition to post-orthodontic EARR in root-filled teeth. Variants in allele 1 of the interleukin-1 receptor antagonist gene(rs419598) are associated(p=0.001**) with an increased risk of suffering post-orthodontic EARR in root-filled teeth.
authors.affiliation: Department of Orthodontics, School of Dentistry, University of Seville, Seville, Spain. brpi@us.es
authors.forename: Alejandro
authors.initials: A
authors.lastname: Iglesias-Linares
authors.forename: Rosa Ma
authors.initials: RM
authors.lastname: Yañez-Vico
authors.forename: Sofía
authors.initials: S
authors.lastname: Ballesta-Mudarra
authors.forename: Estefanía
authors.initials: E
authors.lastname: Ortiz-Ariza
authors.forename: Asunción
authors.initials: A
authors.lastname: Mendoza-Mendoza
authors.forename: Evelio
authors.initials: E
authors.lastname: Perea-Pérez
authors.forename: Ana Ma
authors.initials: AM
authors.lastname: Moreno-Fernández
authors.forename: Enrique
authors.initials: E
authors.lastname: Solano-Reina
mesh_terms: D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications / Q000209:etiology / Q000235:genetics*; D012390:Root Canal Therapy / Q000009:adverse effects*; D012391:Root Resorption / Q000209:etiology / Q000235:genetics*; D055815:Young Adult
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein