title: The effect of lead exposure on brain iron homeostasis and the expression of DMT1/FP1 in the brain in developing and aged rats.
abstract: The relation between lead (Pb) and iron (Fe) becomes increasingly concerned because they are both divalent metals that are absorbed by the same intestinal mechanism, and Pb exposure and Fe deficiency in the developmental brain, as well as Fe overload in the aged brain, can cause cognitive deficits. However, the interaction between Pb exposure and Fe status in the brain has not been established. Therefore, in the current study, we examined the effects of maternal ingestion of Pb in drinking water during gestation and lactation on the Fe status and the expression of divalent metal transporter 1 (DMT1) and ferroportin 1 (FP1) in the brain of offspring. The offspring were followed through old age, with measurements taken at postnatal week 3 (PNW3), 41 (PNW41) and 70 (PNW70). Pb exposure increases the Fe content in the old-aged rats' brain, which might be not subjected to DMT1 mediating, but may be associated with the decrease expression of FP1. Furthermore, the effect of Pb on FP1 expression is regulated at transcriptional and posttranscriptional levels. The perturbation in Fe homeostasis may contribute to the neurotoxicology consequences induced by Pb exposure, and FP1 may play a role in Pb-induced Fe cumulation in the brain.
authors.affiliation: Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China.
authors.forename: Gaochun
authors.initials: G
authors.lastname: Zhu
authors.forename: Guangqin
authors.initials: G
authors.lastname: Fan
authors.forename: Chang
authors.initials: C
authors.lastname: Feng
authors.forename: Yanshu
authors.initials: Y
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Fankun
authors.initials: F
authors.lastname: Zhou
authors.forename: Guihua
authors.initials: G
authors.lastname: Du
authors.forename: Huan
authors.initials: H
authors.lastname: Jiao
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Liu
authors.forename: Xinlan
authors.initials: X
authors.lastname: Xiao
authors.forename: Fen
authors.initials: F
authors.lastname: Lin
authors.forename: Ji
authors.initials: J
authors.lastname: Yan
mesh_terms: D000367:Age Factors; D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D027682:Cation Transport Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D005260:Female; D007150:Immunohistochemistry; D007501:Iron / Q000097:blood / Q000378:metabolism*; D007854:Lead / Q000097:blood / Q000633:toxicity*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D012313:RNA / Q000737:chemistry / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D060888:Real-Time Polymerase Chain Reaction; D013047:Specific Pathogen-Free Organisms; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2
chemical_list: D027682:Cation Transport Proteins; D007501:Iron; D007854:Lead; D012313:RNA; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2