title: Amino acid-based zwitterionic poly(serine methacrylate) as an antifouling material.
abstract: A serine-based zwitterionic poly(serine methacrylate) (pSerMA) was developed in this work to be used as a potential antifouling material. A surface-initiated photoiniferter-mediated polymerization (SI-PIMP) method was used to graft polymer brushes on gold surfaces. The pSerMA-grafted samples with different polymer film thicknesses were readily prepared by varying the UV-irradiation time. With the optimal film thickness, the adsorptions from bovine serum albumin, human serum, and human plasma onto the pSerMA-grafted surfaces, as evaluated by a surface plasmon resonance (SPR) biosensor, were 1.8, 9.2, and 12.9 ng/cm(2), respectively, comparable to the traditional antifouling material such as poly(ethylene glycol). The pSerMA-grafted surfaces also strongly resisted adhesion from bovine aortic endothelial cells. This is the first work to develop an amino acid-based zwitterionic polymer as an antifouling material, demonstrating that pSerMA is a promising alternative to the traditional ethylene glycol-based antifouling materials.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Akron, Akron, OH 44325, USA.
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Liu
authors.forename: Anuradha
authors.initials: A
authors.lastname: Singh
authors.forename: Lingyun
authors.initials: L
authors.lastname: Liu
mesh_terms: D026921:Amino Acid Transport Systems, Neutral / Q000737:chemistry* / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002448:Cell Adhesion / Q000502:physiology; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D008689:Methacrylates / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000378:metabolism
chemical_list: D026921:Amino Acid Transport Systems, Neutral; D000596:Amino Acids; D008689:Methacrylates; D010455:Peptides; C027794:polyserine; D012710:Serum Albumin, Bovine