title: Abnormality of regulatory T-cells in remission and non-remission idiopathic thrombocytopaenic purpura patients.
abstract: Primer immunologic defect in patients with idiopathic thrombocytopaenic purpura (ITP) result from autoreactive B-lymphocytes secreting antiplatelet antibodies. Dysfunctional cellular immunity has also great importance in ITP pathogenesis. CD4(+)CD25(+) regulatory T-cells have immunoregulatory features and it is able to inhibit CD4(+)CD25(-) and CD8(+) responses. ITP is also an autoimmune disease; the CD4(+)CD25(+) T-cell levels of the patients decrease during the active state. According to our findings, immunosuppressive treatments increase the CD4(+)CD25(+) Treg cell levels in the non-remission ITP patients. However, this level is not enough to overcome the resistance. CD4(+)CD25(-)Foxp3(+) and CD4(+)Foxp3(+) Treg cells are responsible for the pathogenesis of the non-remission ITP patients and other factors exist, which are responsible for the resistance of ITP treatment.
authors.affiliation: Department of Hematology, Faculty of Medicine, Eskisehir Osmangazi University , Eskiehir 26480 Turkey.
authors.forename: Hava Üsküdar
authors.initials: HÜ
authors.lastname: Teke
authors.forename: Eren
authors.initials: E
authors.lastname: Gündüz
authors.forename: Olga Meltem
authors.initials: OM
authors.lastname: Akay
authors.forename: Zafer
authors.initials: Z
authors.lastname: Gülbas
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000276:immunology* / Q000628:therapy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism; D016896:Treatment Outcome; D055815:Young Adult