title: Relationship between myocardial performance index and severity of coronary artery disease assessed with SYNTAX score in stable coronary artery disease.
abstract: BACKGROUND
  The aim of the study was to investigate the relationship between severity of coronary artery disease (CAD) assessed with SYNTAX score (SS) and myocardial performance index (MPI) in stable CAD.
  
  
  METHODS
  The study participants consisted of 106 consecutive patients (mean age: 57.6 ± 9.5 years) with angiographically proven obstructive stable CAD and 30 patients with nonobstructive CAD (control group) (mean age: 58.0 ± 7.6 years). The MPI was calculated by using pulsed-wave Doppler before coronary angiography. Coronary angiography was performed in all patients. The SS was prospectively calculated in 106 obstructive CAD patients. Patients were partitioned into 3 groups based on SS. Frequencies of risk factors, biochemical and hematological data were recorded in all patients.
  
  
  RESULTS
  The SS tertiles were defined as SS(low) ≤ 8 (n = 35), SS(mid) ≤ 17 (n = 36), and SS(high) > 17 (n = 35). The patients with SS(high) group (mean MPI; 0,48 ± 0.06) based on SS had significantly higher MPI values compared with the SS(mid) (mean MPI; 0,44 ± 0.05), SS(low) (mean MPI; 0.43 ± 0.06), and control (mean MPI; 0.41 ± 0.05) groups (P < 0.05 for all). The MPI levels of control group were also lower than compared with SS(mid) group (P = 0.006). The MPI value was significantly correlated with SS (r = 0.564, P < 0.001), diabetes (r = 0.355, P < 0.001), hypertension (r = 0.326, P < 0.001), and ejection fraction (EF) (r = -0.224, P = 0.018) in bivariate analysis. Multivariate regression analysis showed that MPI was independently associated with SS (β = 0.486, P < 0.001) and diabetes (β = 0.205, P = 0.028).
  
  
  CONCLUSIONS
  Although the normal EF, MPI value was impaired in proportion to the severity of CAD in patients with stable CAD.
authors.affiliation: Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey. dysahin79@hotmail.com
authors.forename: Durmuş Yıldıray
authors.initials: DY
authors.lastname: Sahin
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Onur Kadir
authors.initials: OK
authors.lastname: Uysal
authors.forename: Betül
authors.initials: B
authors.lastname: Özaltun
authors.forename: Taner
authors.initials: T
authors.lastname: Şeker
authors.forename: Buğra
authors.initials: B
authors.lastname: Özkan
authors.forename: Gülhan Yüksel
authors.initials: GY
authors.lastname: Kalkan
authors.forename: Ali
authors.initials: A
authors.lastname: Kıvrak
authors.forename: Murat
authors.initials: M
authors.lastname: Çaylı
mesh_terms: D000465:Algorithms; D023921:Coronary Stenosis / Q000150:complications* / Q000000981:diagnostic imaging*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology*