title: Cleaning up: ER-associated degradation to the rescue.
abstract: All cellular proteins are subject to quality control "decisions," which help to prevent or delay a myriad of diseases. Quality control within the secretory pathway creates a special challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for proteasomal degradation. This process is termed endoplasmic-reticulum (ER)-associated degradation (ERAD).
authors.affiliation: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. jbrodsky@pitt.edu
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Brodsky
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000502:physiology*; D060746:Endoplasmic Reticulum-Associated Degradation; D006801:Humans; D017510:Protein Folding; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*; D055571:Secretory Pathway
chemical_list: D011506:Proteins