title: Determining the in vivo transverse relaxation time of GABA in the human brain at 7T.
abstract: OBJECTIVE
  To measure in vivo transverse relaxation times (T2 ) of gamma-aminobutyric acid (GABA) at 7T using the experimental spectral-editing method.
  
  
  METHODS
  Experiments were performed at 7T in a 10 mM GABA phantom to determine the intrinsic TE-dependence of the edited signal. Then the same method was applied with editing-based suppression of coedited macromolecular signals to five healthy volunteers to determine T2 of GABA in vivo.
  
  
  RESULTS
  From in vivo data acquired at multiple echo times, the in vivo GABA T2 relaxation time was estimated to be 63 ± 19 msec.
  
  
  CONCLUSIONS
  We present a measurement of the T2 of edited GABA signal at 7T by first using phantom measurements to determine the echo time-dependence of edited signal. The method is purely experimental and does not rely on prior knowledge of coupling constants or simulation of realistic experiments. J. Magn. Reson. Imaging 2013;38:1224-1229. © 2013 Wiley Periodicals, Inc.
authors.affiliation: Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Jarunee
authors.initials: J
authors.lastname: Intrapiromkul
authors.forename: He
authors.initials: H
authors.lastname: Zhu
authors.forename: Ying
authors.initials: Y
authors.lastname: Cheng
authors.forename: Peter B
authors.initials: PB
authors.lastname: Barker
authors.forename: Richard A E
authors.initials: RA
authors.lastname: Edden
mesh_terms: D000328:Adult; D000465:Algorithms; D001923:Brain Chemistry; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D005680:gamma-Aminobutyric Acid / Q000032:analysis* / Q000737:chemistry*
chemical_list: D005680:gamma-Aminobutyric Acid