title: [A long-term survival case of liver epithelioid hemangioendothelioma with multiple lung metastases that regressed by long-term administration of interleukin-2].
abstract: A patient was a 46-year-old man. Multiple lung tumors had been pointed out on a medical examination at age 24. He came to our hospital for further examination. Multiple liver and lung tumors were found out, and epithelioid hemangioendothelioma (EHE) derived from the liver was diagnosed by biopsy. At first we gave recombinant interleukin-2 (rIL-2) by intra-arterial and local injection and then continued it by intramuscular injection for 22 years as maintenance therapy. The tumors have regressed, with partial necrosis. EHE is a rare tumor, but we do not have a standard antitumor therapy except surgical resection. This case suggests that rIL-2 may become a new therapy for EHE. We think that the report of the long-term survival of a case of EHE in which rIL-2 treatment was effective is extremely valuable.
authors.affiliation: Department of Emergency Medicine, The Jikei University School of Medicine, Japan. ohtani@jikei.ac.jp
authors.forename: Kei
authors.initials: K
authors.lastname: Otani
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Aizawa
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fujise
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Koyama
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Ohkusa
authors.forename: Hisao
authors.initials: H
authors.lastname: Tajiri
mesh_terms: D018323:Hemangioendothelioma, Epithelioid / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007273:Injections, Intramuscular; D007376:Interleukin-2 / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: D007376:Interleukin-2; D011994:Recombinant Proteins