title: A systematic review and meta-analysis of the impact of tuberculosis on health-related quality of life.
abstract: OBJECTIVE
  To summarize the impact of tuberculosis (TB) on quantitative measures on self-reported health-related quality of life (HRQOL).
  
  
  METHODS
  We searched eight databases to retrieve all peer-reviewed publications reporting original HRQOL data for persons with TB. All retrieved abstracts were considered for full-text review if HRQOL was quantitatively assessed among subjects with TB. Full-text articles were reviewed by two independent reviewers using a standardized abstraction form to collect data on socio-demographic characteristics, questionnaire administration, and mean HRQOL scores. Meta-analyses were performed for standardized mean differences in HRQOL scores, comparing subjects treated for active TB with subjects treated for latent TB infection (LTBI), or with healthy controls, at similar time points with respect to diagnosis and/or treatment.
  
  
  RESULTS
  From over 15,000 abstracts retrieved, 76 full-text articles were reviewed, which represented 28 unique cohorts (6,028 subjects) reporting HRQOL among subjects with active TB; 42 % were women and mean age was 42 years. Data on key social and behavioral determinants were limited. Within individual studies and in meta-analyses, subjects with active TB disease consistently reported worse HRQOL than concurrently evaluated subjects treated for LTBI. However, meaningful improvements in HRQOL throughout active TB treatment were reported by longitudinal studies.
  
  
  CONCLUSIONS
  In a variety of studies, in different settings and using different instruments, subjects with active TB consistently reported poorer HRQOL than persons treated for LTBI. Future research on HRQOL and TB should better address social and behavioral health determinants which may also affect HRQOL.
authors.affiliation: Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Room K1.28, 3650 St. Urbain, Montreal, QC, H2X 2P4, Canada, melissa.bauer@mail.mcgill.ca.
authors.forename: M
authors.initials: M
authors.lastname: Bauer
authors.forename: A
authors.initials: A
authors.lastname: Leavens
authors.forename: K
authors.initials: K
authors.lastname: Schwartzman
mesh_terms: D006304:Health Status; D006801:Humans; D011788:Quality of Life; D012307:Risk Factors; D018434:Sickness Impact Profile; D012959:Socioeconomic Factors; D014376:Tuberculosis / Q000175:diagnosis / Q000523:psychology*