title: Spread of multidrug-resistant Pseudomonas aeruginosa clones in a university hospital.
abstract: An outbreak of multidrug-resistant Pseudomonas aeruginosa (MDRPA) infections in a university hospital is described. Phenotypic and genotypic analysis of 240 isolates revealed that 152 patients, mainly in the intensive care unit (ICU), were colonized or infected with MDRPA, the majority with O11. All metallo-β-lactamase (MBL)-positive isolates carried the bla(VIM-2) or bla(VIM-1) gene. One or more type III secretion system toxin genes were detected in most isolates. Five dominant pulsed-field gel electrophoresis (PFGE) types were characterized, associated with ST235, ST111, ST253, ST309, and ST639.
authors.affiliation: Department of Microbiology, School of Medicine, University of Patras, Patras, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Koutsogiannou
authors.forename: Eleanna
authors.initials: E
authors.lastname: Drougka
authors.forename: Apostolos
authors.initials: A
authors.lastname: Liakopoulos
authors.forename: Eleni
authors.initials: E
authors.lastname: Jelastopulu
authors.forename: Efthimia
authors.initials: E
authors.lastname: Petinaki
authors.forename: Evangelos D
authors.initials: ED
authors.lastname: Anastassiou
authors.forename: Iris
authors.initials: I
authors.lastname: Spiliopoulou
authors.forename: Myrto
authors.initials: M
authors.lastname: Christofidou
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016000:Cluster Analysis; D003428:Cross Infection / Q000175:diagnosis* / Q000453:epidemiology; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests; D058889:Molecular Typing; D011552:Pseudomonas Infections / Q000175:diagnosis* / Q000453:epidemiology; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000187:drug effects* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents