title: Mean platelet volume is increased in infective endocarditis and decreases after treatment.
abstract: OBJECTIVE
  The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation in patients with infective endocarditis.
  
  
  METHODS
  Twenty-nine patients with infective endocarditis and 29 healthy subjects were studied. Plasma MPV values in patients and control subjects were measured on admission and after 2 weeks of specific treatment of infective endocarditis.
  
  
  RESULTS
  The MPV was significantly higher among patients with infective endocarditis when compared with the control group (9.86 ± 1.1 vs. 8.0 ± 1.0 fl, respectively; p < 0.01). The MPV values of patients with infective endocarditis decreased significantly after treatment from 9.86 ± 1.1 to 7.86 ± 1.0 fl (p < 0.01). Total platelet counts increased significantly after treatment from 193.4 ± 96.5 × 10(9) to 243.7 ± 92.4 × 10(9) (p = 0.04).
  
  
  CONCLUSIONS
  MPV values were higher in patients with infective endocarditis and decreased significantly after treatment. Elevated MPV values indicate that patients with infective endocarditis have increased platelet activation and infective endocarditis treatment decreases this platelet activation by decreasing MPV.
authors.affiliation: Department of Cardiology, Ahi Evran University Education and Research Hospital, Kirsehir, Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Icli
authors.forename: Senol
authors.initials: S
authors.lastname: Tayyar
authors.forename: Ercan
authors.initials: E
authors.lastname: Varol
authors.forename: Fatih
authors.initials: F
authors.lastname: Aksoy
authors.forename: Akif
authors.initials: A
authors.lastname: Arslan
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ersoy
authors.forename: Selahaddin
authors.initials: S
authors.lastname: Akcay
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000378:metabolism*; D015897:Comorbidity; D003584:Cytological Techniques; D004696:Endocarditis / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000187:drug effects / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D008055:Lipids