title: The brain circuitry mediating antipruritic effects of acupuncture.
abstract: Itch is an aversive sensory experience and while systemic therapies, such as acupuncture, have shown promise in alleviating itch in patients suffering from chronic itch, their antipruritic mechanisms are unknown. As several lines of evidence implicate brain-focused mechanisms, we applied functional magnetic resonance imaging and our validated temperature-modulation itch model to evaluate the underlying brain circuitry supporting allergen-induced itch reduction in atopic dermatitis patients by acupuncture, antihistamine, and respective placebo treatments. Brain response to allergen itch demonstrated phase dependency. During an increasing itch phase, activation was localized in anterior insula and striatum, regions associated with salience/interoception and motivation processing. Once itch reached peak plateau, robust activation was noted in prefrontal cognitive and premotor areas. Acupuncture reduced itch and itch-evoked activation in the insula, putamen, and premotor and prefrontal cortical areas. Neither itch sensation nor itch-evoked brain response was altered following antihistamine or placebo acupuncture. Greater itch reduction following acupuncture was associated with greater reduction in putamen response, a region implicated in motivation and habitual behavior underlying the urge to scratch, specifically implicating this region in acupuncture's antipruritic effects. Understanding brain circuitry underlying itch reduction following acupuncture and related neuromodulatory therapies will significantly impact the development and applicability of novel therapies to reduce an itch.
authors.affiliation: Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
authors.forename: Vitaly
authors.initials: V
authors.lastname: Napadow
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.forename: Marco L
authors.initials: ML
authors.lastname: Loggia
authors.forename: Jieun
authors.initials: J
authors.lastname: Kim
authors.forename: Peter C
authors.initials: PC
authors.lastname: Schalock
authors.forename: Ethan
authors.initials: E
authors.lastname: Lerner
authors.forename: Thanh-Nga
authors.initials: TN
authors.lastname: Tran
authors.forename: Johannes
authors.initials: J
authors.lastname: Ring
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Rosen
authors.forename: Ted J
authors.initials: TJ
authors.lastname: Kaptchuk
authors.forename: Florian
authors.initials: F
authors.lastname: Pfab
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods*; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000982:Antipruritics / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology*; D001931:Brain Mapping; D018592:Cross-Over Studies; D003876:Dermatitis, Atopic / Q000209:etiology / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011537:Pruritus / Q000473:pathology* / Q000628:therapy*; D011601:Psychophysics; D055815:Young Adult
chemical_list: D000982:Antipruritics; D010100:Oxygen