title: The chemokine receptor CXCR2 and coronavirus-induced neurologic disease.
abstract: Inoculation with the neurotropic JHM strain of mouse hepatitis virus (MHV) into the central nervous system (CNS) of susceptible strains of mice results in an acute encephalomyelitis in which virus preferentially replicates within glial cells while excluding neurons. Control of viral replication during acute disease is mediated by infiltrating virus-specific T cells via cytokine secretion and cytolytic activity, however sterile immunity is not achieved and virus persists resulting in chronic neuroinflammation associated with demyelination. CXCR2 is a chemokine receptor that upon binding to specific ligands promotes host defense through recruitment of myeloid cells to the CNS as well as protecting oligodendroglia from cytokine-mediated death in response to MHV infection. These findings highlight growing evidence of the diverse and important role of CXCR2 in regulating neuroinflammatory diseases.
authors.affiliation: Department of Molecular Biology & Biochemistry, UC Irvine, CA 92697-3900, USA.
authors.forename: Jason G
authors.initials: JG
authors.lastname: Weinger
authors.forename: Brett S
authors.initials: BS
authors.lastname: Marro
authors.forename: Martin P
authors.initials: MP
authors.lastname: Hosking
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Lane
mesh_terms: D000208:Acute Disease; D000818:Animals; D002465:Cell Movement; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology / Q000821:virology*; D018352:Coronavirus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D016207:Cytokines / Q000096:biosynthesis; D003711:Demyelinating Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology*; D004679:Encephalomyelitis / Q000276:immunology / Q000473:pathology / Q000821:virology*; D051379:Mice; D006517:Murine hepatitis virus / Q000472:pathogenicity / Q000502:physiology*; D022423:Myeloid Cells / Q000276:immunology / Q000821:virology; D009836:Oligodendroglia / Q000276:immunology / Q000473:pathology / Q000821:virology*; D023063:Receptors, Interleukin-8B / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology; D014779:Virus Replication
chemical_list: D016207:Cytokines; D023063:Receptors, Interleukin-8B