title: [Efficacy is good, impact is great].
abstract: This article summarizes the different stages of research for the development of medical interventions and their specific characteristics in terms of design, population, resources, importance of results and scientific interest. The emphasis is focused on the two final stages of development, the effectiveness and the impact. An example from our own experience is given to illustrate the reduction of the effect of an intervention against malaria in young children at different stages of the development of the intervention, and the parallel decrease of the recognition by the scientific community of the importance of these results.
authors.affiliation: Division des maladies Infectieuses, CHUV, 1011 Lausanne. nicolas.senn@hospvd.ch
authors.forename: N
authors.initials: N
authors.lastname: Senn
authors.forename: C
authors.initials: C
authors.lastname: Lengeler
authors.forename: J
authors.initials: J
authors.lastname: Cornuz
authors.forename: B
authors.initials: B
authors.lastname: Genton
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use; D035843:Biomedical Research / Q000379:methods*; D002648:Child; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D008288:Malaria / Q000188:drug therapy*
chemical_list: D000962:Antimalarials