title: New physiological insights into dyspnea and exercise intolerance in chronic obstructive pulmonary disease patients.
abstract: Dyspnea and reduced exercise tolerance are common consequences of chronic obstructive pulmonary disease (COPD) and contribute importantly to poor perceived health status. While the origins of dyspnea and reduced exercise tolerance are complex and multifactorial, there is increasing evidence that lung hyperinflation is an important contributory factor that can be targeted for treatment. In this review, the authors summarize current concepts of the origin and clinical and physiological consequences of both static and dynamic lung hyperinflation in COPD. In particular, they review recent studies that have examined the role of lung hyperinflation in dyspnea causation during exacerbations and physical activity in COPD. Finally, current concepts of the mechanisms of symptom relief and improved exercise tolerance following pharmacological lung volume reduction are reviewed.
authors.affiliation: Université de Paris 06, Equipe de Recherche ER 10 UPMC, Laboratoire de Physio-Pathologie Respiratoire, Faculté de Médecine Pierre et Marie Curie (site Pitié-Salpêtrière), Paris, 75013, France.
authors.forename: Pierantonio
authors.initials: P
authors.lastname: Laveneziana
authors.forename: Jordan A
authors.initials: JA
authors.lastname: Guenette
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Webb
authors.forename: Denis E
authors.initials: DE
authors.lastname: O'Donnell
mesh_terms: D001993:Bronchodilator Agents / Q000627:therapeutic use; D003964:Diaphragm / Q000503:physiopathology; D004417:Dyspnea / Q000188:drug therapy / Q000503:physiopathology*; D017079:Exercise Tolerance / Q000502:physiology*; D006801:Humans; D008176:Lung Volume Measurements; D009119:Muscle Contraction / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000503:physiopathology*; D015656:Respiratory Mechanics / Q000502:physiology; D012132:Respiratory Muscles / Q000503:physiopathology
chemical_list: D001993:Bronchodilator Agents