title: Extracting MRS discriminant functional features of brain tumors.
abstract: The current challenge in automatic brain tumor classification based on MRS is the improvement of the robustness of the classification models that explicitly account for the probable breach of the independent and identically distributed conditions in the MRS data points. To contribute to this purpose, a new algorithm for the extraction of discriminant MRS features of brain tumors based on a functional approach is presented. Functional data analysis based on region segmentation (RSFDA) is based on the functional data analysis formalism using nonuniformly distributed B splines according to spectral regions that are highly correlated. An exhaustive characterization of the method is presented in this work using controlled and real scenarios. The performance of RSFDA was compared with other widely used feature extraction methods. In all simulated conditions, RSFDA was proven to be stable with respect to the number of variables selected and with respect to the classification performance against noise and baseline artifacts. Furthermore, with real multicenter datasets classification, RSFDA and peak integration (PI) obtained better performance than the other feature extraction methods used for comparison. Other advantages of the method proposed are its usefulness in selecting the optimal number of features for classification and its simplified functional representation of the spectra, which contributes to highlight the discriminative regions of the MR spectrum for each classification task.
authors.affiliation: Biomedical Informatics Group (IBIME-ITACA), Universitat Politècnica de València, Valencia, Spain. elfusgar@upv.es
authors.forename: Elies
authors.initials: E
authors.lastname: Fuster-Garcia
authors.forename: Salvador
authors.initials: S
authors.lastname: Tortajada
authors.forename: Javier
authors.initials: J
authors.lastname: Vicente
authors.forename: Montserrat
authors.initials: M
authors.lastname: Robles
authors.forename: Juan M
authors.initials: JM
authors.lastname: García-Gómez
mesh_terms: D000465:Algorithms; D001932:Brain Neoplasms / Q000378:metabolism*; D020000:Decision Support Systems, Clinical; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D012372:ROC Curve