title: Bilateral mediastinal neurofibroma of the vagus nerves in a patient with neurofibromatosis type 1.
abstract: Bilateral mediastinal vagus neurogenic tumors are very rare. We herein report the case of Neurofibromatosis type 1 (NF-1) patient with bilateral neurofibromas originating from the mediastinal vagus just distal site of the recurrent nerve, who underwent two-staged extirpations that successfully preserved both recurrent nerves. A 31-year-old female with a history of NF-1 was admitted to our hospital under a diagnosis of multiple tumors in the upper mediastinum. First, the tumor at the right paratracheal to precarinal site was completely resected through a median sternotomy, preserving the right recurrent nerve. After confirming no right recurrent nerve paralysis, thoracoscopic resection of the tumor at the aorto-pulmonary window was then performed preserving the left recurrent nerve. The histopathological diagnosis was neurofibroma originating from the bilateral mediastinal vagus nerves. A two-staged operation can be an option in cases with bilateral mediastinal vagus nerve tumors to avoid the risk of bilateral recurrent nerve paralysis.
authors.affiliation: Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Ryu
authors.initials: R
authors.lastname: Kanzaki
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Inoue
authors.forename: Masato
authors.initials: M
authors.lastname: Minami
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Sawabata
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shintani
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Nakagiri
authors.forename: Meinoshin
authors.initials: M
authors.lastname: Okumura
mesh_terms: D000328:Adult; D001706:Biopsy; D003390:Cranial Nerve Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008479:Mediastinal Neoplasms / Q000473:pathology / Q000601:surgery*; D009456:Neurofibromatosis 1 / Q000473:pathology / Q000601:surgery*; D061226:Recurrent Laryngeal Nerve Injuries / Q000209:etiology / Q000517:prevention & control; D056346:Sternotomy; D013906:Thoracoscopy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014628:Vagotomy; D014630:Vagus Nerve / Q000473:pathology / Q000601:surgery*; D020421:Vagus Nerve Diseases / Q000473:pathology / Q000601:surgery*; D014826:Vocal Cord Paralysis / Q000209:etiology / Q000517:prevention & control