title: Novel 3-hydroxy vinylboronates influence sphingolipid metabolism, cause apoptosis in Jurkat cells and prevent tumor development in nude mice.
abstract: A series of novel 3-hydroxy vinylboronates which share structural similarities with sphingolipids were synthesized and tested in vitro and in vivo as anticancer agents. The molecules reduced cancer cell survival in vitro by influencing their sphingolipid metabolism. In a cancer model in nude mice the lead compound E7 prevented the development of tumor as long as the treatment period continued. Moreover, it delayed tumor growth after the treatment was finished.
authors.affiliation: Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 91120, Israel. alinabo@ekmd.huji.ac.il
authors.forename: Alina
authors.initials: A
authors.lastname: Botvinik Livshits
authors.forename: Abed Al Aziz
authors.initials: AA
authors.lastname: Al Quntar
authors.forename: Zhanna
authors.initials: Z
authors.lastname: Yekhtin
authors.forename: Morris
authors.initials: M
authors.lastname: Srebnik
authors.forename: Arie
authors.initials: A
authors.lastname: Dagan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D001897:Boronic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D006900:Hydroxylation; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells; D051379:Mice; D008819:Mice, Nude; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000517:prevention & control; D013107:Sphingolipids / Q000378:metabolism; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D013107:Sphingolipids; D014753:Vinyl Compounds