title: Chemo/tomotherapy stereotactic body radiation therapy (chemo/SBRT) for the salvage treatment of esophageal carcinoma following trimodality therapy: a case report.
abstract: BACKGROUND
  Esophageal cancer (EC) patients presenting a local recurrence following trimodality therapy (chemoradiaton and surgery) have limited palliative treatment options when the three major modalities of therapy have been exhausted. In addition, some patients experience a local recurrence or develop a metachronous cancer in a previously irradiated site, without evidence of systemic disease. For these patients there is a potential for cure, although the risk of further distant recurrences remains high.
  
  
  METHODS
  We report of a successful concomitant chemo/SBRT treatment in a case of locally advanced metachronous squamous cervical EC, which was diagnosed in a patient previously treated with trimodality therapy for a squamous tonsillar carcinoma.
  
  
  RESULTS
  Chemo/SBRT seems to be a reasonable salvage option for patients without distant metastases who have exhausted standard therapies.
  
  
  CONCLUSIONS
  Our experience also suggests that a concomitant chemo/SBRT treatment appears to be either feasible or effective and chemo/SBRT can be considered also in selected patients affected by EC with squamous histology and with neoplastic infiltration of the trachea.
authors.affiliation: Oncology, Santa Maria degli Angeli Hospital, via Montereale 34, Pordenone, Italy. davidesanteufemia@gmail.com
authors.forename: Davide Adriano
authors.initials: DA
authors.lastname: Santeufemia
authors.forename: Salvatore
authors.initials: S
authors.lastname: Tumolo
authors.forename: Antonino
authors.initials: A
authors.lastname: De Paoli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lo Re
authors.forename: Gianni
authors.initials: G
authors.lastname: Boz
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Miolo
authors.forename: Tanja
authors.initials: T
authors.lastname: Baresic
authors.forename: Stefano Maria Massimiliano
authors.initials: SM
authors.lastname: Basso
authors.forename: Roberto
authors.initials: R
authors.lastname: Innocente
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001999:Bronchoscopy; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000556:secondary / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003287:Contrast Media; D003680:Deglutition Disorders / Q000209:etiology; D019583:Dose Fractionation, Radiation; D004938:Esophageal Neoplasms / Q000150:complications / Q000556:secondary / Q000628:therapy*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000150:complications / Q000628:therapy*; D049268:Positron-Emission Tomography; D016634:Radiosurgery; D018714:Radiotherapy, Adjuvant; D016879:Salvage Therapy / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014067:Tonsillar Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D015431:Weight Loss; D014916:Whole-Body Irradiation
chemical_list: D003287:Contrast Media; D019788:Fluorodeoxyglucose F18