title: Toluene derivatives as simple coupling precursors for cascade palladium-catalyzed oxidative C-H bond acylation of acetanilides.
abstract: A palladium-catalyzed cascade cross-coupling of acetanilide and toluene for the synthesis of ortho-acylacetanilide is described. Toluene derivatives can act as effective acyl precursors (upon sp(3)-C-H bond oxidation by a Pd/TBHP system) in the oxidative coupling between two C-H bonds. This dehydrogenative Pd-catalyzed ortho-acylation proceeds under mild reaction conditions.
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Yinuo
authors.initials: Y
authors.lastname: Wu
authors.forename: Pui Ying
authors.initials: PY
authors.lastname: Choy
authors.forename: Fei
authors.initials: F
authors.lastname: Mao
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong
mesh_terms: D000083:Acetanilides / Q000737:chemistry*; D000215:Acylation; D002384:Catalysis; D010165:Palladium / Q000737:chemistry; D014050:Toluene / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000083:Acetanilides; D014050:Toluene; D010165:Palladium