title: Electrophysiological low-frequency coherence and cross-frequency coupling contribute to BOLD connectivity.
abstract: Brain networks are commonly defined using correlations between blood oxygen level-dependent (BOLD) signals in different brain areas. Although evidence suggests that gamma-band (30-100 Hz) neural activity contributes to local BOLD signals, the neural basis of interareal BOLD correlations is unclear. We first defined a visual network in monkeys based on converging evidence from interareal BOLD correlations during a fixation task, task-free state, and anesthesia, and then simultaneously recorded local field potentials (LFPs) from the same four network areas in the task-free state. Low-frequency oscillations (<20 Hz), and not gamma activity, predominantly contributed to interareal BOLD correlations. The low-frequency oscillations also influenced local processing by modulating gamma activity within individual areas. We suggest that such cross-frequency coupling links local BOLD signals to BOLD correlations across distributed networks.
authors.affiliation: Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA. wanglbit@gmail.com
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Yuri B
authors.initials: YB
authors.lastname: Saalmann
authors.forename: Mark A
authors.initials: MA
authors.lastname: Pinsk
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Arcaro
authors.forename: Sabine
authors.initials: S
authors.lastname: Kastner
mesh_terms: D000758:Anesthesia; D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000502:physiology*; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology*; D004569:Electroencephalography; D005403:Fixation, Ocular / Q000502:physiology; D007091:Image Processing, Computer-Assisted; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000098:blood supply* / Q000502:physiology*; D010100:Oxygen; D010775:Photic Stimulation; D012146:Rest; D013223:Statistics as Topic
chemical_list: D010100:Oxygen