title: [Simultaneous determination of nine phthalate esters and bisphenol A in cosmetics by ultra-high performance liquid chromatography].
abstract: OBJECTIVE
  An ultra-performance liquid chromatography method has been established for the simultaneous determination of 9 phthalate esters and bisphenol A in cosmetics.
  
  
  METHODS
  The samples were extracted by methanol and determined by ultra-high performance liquid chromatography with PDA detector. The separation of 9 phthalate esters and bisphenol A was carried out by an Phenyl column (50 mm x 2.1 mm id, 1.7 microm) column and quantification was based on detection wavelength at 275 nm.
  
  
  RESULTS
  The linear ranges of the calibration curves for 9 phthalate esters and bisphenol A were 10-300 microg/ml and 5-150 micro g/ml, respectively. The correlation coefficients of the standard curves were all higher than 0.9996. The limits of detection (LODs) for phthalate esters were 0.4-0.81 microg/ml and bisphenol A was 0.2 microg/ml. The average recoveries at the concentrations studied were in the range from 91.9% to 105.4%. Relative standard deviations were all less than 5.23%.
  
  
  CONCLUSIONS
  The method is simple, fast and effective, and could meet the needs for routine analysis of the 9 phthalate esters and bisphenol A in cosmetics.
authors.affiliation: Beijing Center for Disease Prevention and Control, Beijing 100013, China. liuyuhong_1116@126.com
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Li
mesh_terms: D001559:Benzhydryl Compounds / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003358:Cosmetics / Q000737:chemistry*; D004952:Esters / Q000032:analysis*; D010636:Phenols / Q000032:analysis*; D010795:Phthalic Acids / Q000032:analysis*; D012680:Sensitivity and Specificity; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D003358:Cosmetics; D004952:Esters; D010636:Phenols; D010795:Phthalic Acids; C032279:phthalic acid; C006780:bisphenol A; D000098826:Bisphenol A Compounds