title: Screening of medicinal and edible plants in Okinawa, Japan, for enhanced proliferative and collagen synthesis activities in NB1RGB human skin fibroblast cells.
abstract: To identify plants with bioactive potential for skin care, methanol extracts of 56 plant parts from 47 medical and edible plants cultivated in Okinawa were tested for their proliferative effects on NB1RGB skin fibroblast cells. Extracts from six plants, Bischofia javanica, Colocasia esculenta, Melaleuca alternifolia, Piper angustifolia, Jasminum sambac, and Curcuma longa, showed higher NB1RGB cell proliferation activity (>10%) than the control, at various concentrations. Among the six extracts, only the C. longa extract caused an increase in collagen synthesis in NB1RGB cells, as compared to treatment with the positive control, ascorbic acid (AsA). Expression of the collagen synthesis marker, transforming growth factor-β1, was higher after treatment with the C. longa extract than with AsA.
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Okinawa, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yonathan
authors.initials: Y
authors.lastname: Asikin
authors.forename: Kensaku
authors.initials: K
authors.lastname: Takara
authors.forename: Koji
authors.initials: K
authors.lastname: Wada
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D024042:Collagen Type I / Q000096:biosynthesis*; D004353:Drug Evaluation, Preclinical; D005347:Fibroblasts / Q000166:cytology*; D006801:Humans; D007564:Japan; D010936:Plant Extracts / Q000494:pharmacology*; D010945:Plants, Edible / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D012867:Skin / Q000166:cytology*
chemical_list: D024042:Collagen Type I; D010936:Plant Extracts