title: Gene and protein alterations of FKBP5 and glucocorticoid receptor in the amygdala of suicide victims.
abstract: Recent reports suggest that FKBP5 gene and its corresponding FKBP5 protein play a relevant role in the regulation of anxiety and depression in animal models and human stress-related disorders. In the present study, FKBP5 and glucocorticoid receptor (GR) gene and protein expression were analyzed in the amygdala (AMY) of suicide victims (n=13 males, without clinical psychiatric history and non-treated with anxiolytic or antidepressant drugs) and its corresponding controls (n=13 males) by real-time PCR and Western blotting. The results revealed that FKBP5 and GR gene expression were significantly reduced in the AMY (-38% and -48%, respectively) of suicide victims compared with controls. Interestingly, FKBP5 and GR protein expression were also significantly decreased (-41% and -42%, respectively) in the AMY of suicide victims compared with controls. These results suggest that the FKBP5 plays a relevant role in human emotional responses and suggest this receptor as a new promising target in the treatment of suicide behavior.
authors.affiliation: Unidad de Neuropsicofarmacología Traslacional, Complejo Hospitalario Universitario de Albacete, C/Hermanos Falcó 37, Albacete 02006, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Pérez-Ortiz
authors.forename: María S
authors.initials: MS
authors.lastname: García-Gutiérrez
authors.forename: Francisco
authors.initials: F
authors.lastname: Navarrete
authors.forename: Salvador
authors.initials: S
authors.lastname: Giner
authors.forename: Jorge
authors.initials: J
authors.lastname: Manzanares
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000679:Amygdala / Q000378:metabolism*; D016022:Case-Control Studies; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012313:RNA / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism*; D013405:Suicide; D022021:Tacrolimus Binding Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism*; D000099159:Tacrolimus Binding Protein 5
chemical_list: D012313:RNA; D011965:Receptors, Glucocorticoid; D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5