title: Protective effect of myricetin in dextran sulphate sodium-induced murine             ulcerative colitis.
abstract: In the present study, the protective effect of myricetin administered orally at 200, 100 or 50 mg/kg for 10 days was evaluated in a murine model of acute experimental colitis induced by dextran sulphate sodium (DSS). Macroscopic analysis was carried out to determine the effect of myricetin on pro-inflammatory cytokines, inflammatory markers and oxidative damage in biopsies of colonic tissues. The results showed that treatment with myricetin ameliorated body weight loss in a dose-dependent manner and significantly reduced histology scores. Myricetin decreased the production of nitric oxide (NO), myeloperoxidase (MPO) and malondialdehyde (MDA), while increasing the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Furthermore, the levels of the cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) were significantly decreased. Taken together, the results suggest that the anticolitis effects of myricetin may be attributed to anti-inflammatory and antioxidant actions. Additional investigation is required to determine the detailed mechanisms of action.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Jilin University,                     Changchun 130021, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Tie
authors.initials: T
authors.lastname: Hong
authors.forename: Man
authors.initials: M
authors.lastname: Dong
authors.forename: Yixiao
authors.initials: Y
authors.lastname: Meng
authors.forename: Jiaye
authors.initials: J
authors.lastname: Mu
mesh_terms: D000818:Animals; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D003106:Colon / Q000187:drug effects / Q000378:metabolism; D016264:Dextran Sulfate / Q000633:toxicity; D005260:Female; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism; D015431:Weight Loss / Q000187:drug effects
chemical_list: D005419:Flavonoids; D053583:Interleukin-1beta; D015850:Interleukin-6; D020011:Protective Agents; D009569:Nitric Oxide; D008315:Malondialdehyde; C040015:myricetin; D016264:Dextran Sulfate; D009195:Peroxidase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase