title: In vitro pharmacodynamics of AZD5206 against Staphylococcus aureus.
abstract: AZD5206 is a novel antimicrobial agent with potent in vitro activity against Staphylococcus aureus. We evaluated the in vitro pharmacodynamics of AZD5206 against a standard wild-type methicillin-susceptible strain (ATCC 29213) and a clinical strain of methicillin-resistant S. aureus (SA62). Overall, bacterial killing against a low baseline inoculum was more remarkable. Low dosing exposures and/or high baseline inoculum resulted in early reduction in bacterial burden, followed by regrowth and selective amplification of the resistant population.
authors.affiliation: Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, Texas, USA. vtam@uh.edu
authors.forename: Vincent H
authors.initials: VH
authors.lastname: Tam
authors.forename: Kai-Tai
authors.initials: KT
authors.lastname: Chang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.forename: Joseph
authors.initials: J
authors.lastname: Newman
authors.forename: Ming
authors.initials: M
authors.lastname: Hu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009930:Organic Chemicals / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000382:microbiology
chemical_list: C582395:AZD5206; D000900:Anti-Bacterial Agents; D009930:Organic Chemicals