title: Primary prevention of macroangiopathy in patients with short-duration type 2 diabetes by intensified multifactorial intervention: seven-year follow-up of diabetes complications in Chinese.
abstract: OBJECTIVE
  To explore whether intensified, multifactorial intervention could prevent macrovascular disease in patients with recently diagnosed type 2 diabetes.
  
  
  METHODS
  A total of 150 type 2 diabetic patients, with disease duration of <1 year and without clinical arteriosclerotic disease or subclinical atherosclerotic signs confirmed by ultrasonographic scanning of three conducting arteries, were randomized into an intensive intervention group and a conventional intervention group. They then received intensive, multifactorial intervention or conventional intervention over 7 years of follow-up. The patients' common carotid intima-media thicknesses (CC-IMTs) were measured every year. The primary outcome was the time to the first occurrence of CC-IMTs ≥1.0 mm and/or development of atherosclerosis plaques in the carotid artery. The secondary outcome was clinical evidence of cardiovascular disease.
  
  
  RESULTS
  A total of 70 patients in the intensive group and 68 patients in the conventional group completed the 7-year follow-up. Subclinical macrovascular (primary) outcomes occurred in seven cases in the intensive group and 22 cases in the conventional group for a cumulative prevalence of 10.00 and 32.35%, respectively (P < 0.05). No significant differences between the two groups were observed regarding the secondary outcome.
  
  
  CONCLUSIONS
  Primary prevention of macrovascular diseases can be achieved through intensified, multifactorial intervention in patients with short-duration type 2 diabetes. Type 2 diabetic patients should undergo intensive multifactorial interventions with individual targets for the prevention of macrovascular diseases.
authors.affiliation: Department of Endocrinology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.forename: Jun-jie
authors.initials: JJ
authors.lastname: Yao
authors.forename: Jian-ling
authors.initials: JL
authors.lastname: Du
authors.forename: Ran
authors.initials: R
authors.lastname: Bai
authors.forename: Li-peng
authors.initials: LP
authors.lastname: Sun
authors.forename: Guo-hua
authors.initials: GH
authors.lastname: Sun
authors.forename: Gui-rong
authors.initials: GR
authors.lastname: Song
authors.forename: Si-ming
authors.initials: SM
authors.lastname: Cao
authors.forename: Chun-hong
authors.initials: CH
authors.lastname: Shi
authors.forename: Ying
authors.initials: Y
authors.lastname: Ba
authors.forename: Qian
authors.initials: Q
authors.lastname: Xing
authors.forename: Xue-yang
authors.initials: XY
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D059168:Carotid Intima-Media Thickness; D048909:Diabetes Complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged