title: Common variable immunodeficiency: crossroads between infections, inflammation and autoimmunity.
abstract: Common variable immunodeficiency is a collection of diseases characterized by primary hypogammaglobulinemia. The causes of CVID are extremely heterogeneous and may affect virtually every pathway linked to B cell development and function. Clinical manifestations of CVID mainly include recurrent bacterial infections, but autoimmune, gastrointestinal, lymphoproliferative, granulomatous, and malignant disorders have also been frequently reported as associated conditions. We aimed to focus on the state of the art of the relationship between infections, inflammation and autoimmunity in CVID.
authors.affiliation: Centro Universitario di Ricerche di Immunologia Clinica, Immunopatologia e Documentazione su Malattie Rare (CMID), Università di Torino, Ospedale G. Bosco, Turin, Italy. simone.baldovino@unito.it
authors.forename: Simone
authors.initials: S
authors.lastname: Baldovino
authors.forename: Davide
authors.initials: D
authors.lastname: Montin
authors.forename: Silvana
authors.initials: S
authors.lastname: Martino
authors.forename: Savino
authors.initials: S
authors.lastname: Sciascia
authors.forename: Elisa
authors.initials: E
authors.lastname: Menegatti
authors.forename: Dario
authors.initials: D
authors.lastname: Roccatello
mesh_terms: D000361:Agammaglobulinemia / Q000276:immunology; D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology; D017074:Common Variable Immunodeficiency / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology