title: Novel strategies for anterior segment ocular drug delivery.
abstract: Research advancements in pharmaceutical sciences have led to the development of new strategies in drug delivery to anterior segment. Designing a new delivery system that can efficiently target the diseased anterior ocular tissue, generate high drug levels, and maintain prolonged and effective concentrations with no or minimal side effects is the major focus of current research. Drug delivery by traditional method of administration via topical dosing is impeded by ocular static and dynamic barriers. Various products have been introduced into the market that prolong drug retention in the precorneal pocket and to improve bioavailability. However, there is a need of a delivery system that can provide controlled release to treat chronic ocular diseases with a reduced dosing frequency without causing any visual disturbances. This review provides an overview of anterior ocular barriers along with strategies to overcome these ocular barriers and deliver therapeutic agents to the affected anterior ocular tissue with a special emphasis on nanotechnology-based drug delivery approaches.
authors.affiliation: Division of Pharmaceutical Sciences, University of Missouri-Kansas City, Kansas City, MO 64108-2718, USA.
authors.forename: Kishore
authors.initials: K
authors.lastname: Cholkar
authors.forename: Sulabh P
authors.initials: SP
authors.lastname: Patel
authors.forename: Aswani Dutt
authors.initials: AD
authors.lastname: Vadlapudi
authors.forename: Ashim K
authors.initials: AK
authors.lastname: Mitra
mesh_terms: D060433:Administration, Ophthalmic; D000818:Animals; D000869:Anterior Eye Segment / Q000187:drug effects* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D005128:Eye Diseases / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D011355:Prodrugs / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D011355:Prodrugs