title: Hypolipidemic effect of Semecarpus anacardium in high cholesterol fed hypercholesterolemic rats.
abstract: OBJECTIVE:                To evaluate the hypolipidemic effect of Semecarpus anacardium Linn nut milk extract (SA) in high cholesterol fed hyperlipidemic rat model.                            METHODS:                Rats were divided into four groups which included control animals, hypercholesterolemic animals, hypercholesterolemic animals treated with SA (200 mg/kg body weight dissolved in olive oil), and drug control rats. Lipid levels in serum and liver, and lipid metabolising enzymes were determined after treatment.                            RESULTS:                High cholesterol diet significantly (P<0.05) increased the lipid levels in serum and liver and altered the activities of lipid metabolising enzymes. Significant decrease (P<0.05) in plasma and liver lipid levels were observed whereas the drug ameliorated the activities of lipid metabolising enzymes in drug treated groups.                            CONCLUSIONS:                SA demonstrated remarkable hypolipidemic activity in high cholesterol fed hypercholesterolemic rats. The potential antihyperlipidemic action is plausibly due to its underlying antioxidant role.
authors.affiliation: Department of Medical Biochemistry, Dr. ALM PG. Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600113, India.
authors.forename: Kaladevi Siddhi
authors.initials: KS
authors.lastname: Vinayagam
authors.forename: Haseena Banu Hedayathullah
authors.initials: HB
authors.lastname: Khan
authors.forename: G
authors.initials: G
authors.lastname: Keerthiga
authors.forename: Shanthi
authors.initials: S
authors.lastname: Palanivelu
authors.forename: Sachdanandam
authors.initials: S
authors.lastname: Panchanatham