title: Status of TIM-1 exon 4 haplotypes and CD4+T cell counts in HIV-1 seroprevalent North Indians.
abstract: The TIM (T cell/transmembrane, immunoglobulin and mucin) proteins are crucial regulators of Th1/Th2 immune responses and have been implicated in several diseases including HIV-1/AIDS. The TIM1 exon 4 that codes for mucin domain is highly diverse, with sequence variants associated with varying phenotypes. In this study, TIM1 exon 4 was sequenced among 227 HIV-1 seroprevalent and 288 healthy non infected individuals from North Indian population and haplotypes established. A novel but rare haplotype D1(∗) was identified among the healthy and differed from D1 by a synonymous substitution G>T at Thr208Thr. The TIM1 haplotype diversity showed no association with susceptibility to HIV-1 infection. The seroprevalent individuals carrying D3A had relatively higher median CD4+T cell counts (368/μl) than those without (313/μl; p=0.02). A comparison of CD4+T counts between D3-A individuals on ART or ART naïve did not show any significant difference plausibly due to confounding nature of ART and other factors.
authors.affiliation: Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Sharma
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohtani
authors.forename: Gurvinder
authors.initials: G
authors.lastname: Kaur
authors.forename: Taeko K
authors.initials: TK
authors.lastname: Naruse
authors.forename: S K
authors.initials: SK
authors.lastname: Sharma
authors.forename: Madhu
authors.initials: M
authors.lastname: Vajpayee
authors.forename: Akinori
authors.initials: A
authors.lastname: Kimura
authors.forename: Narinder
authors.initials: N
authors.lastname: Mehra
mesh_terms: D000483:Alleles; D018791:CD4 Lymphocyte Count; D005091:Exons; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006239:Haplotypes; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D007194:India / Q000453:epidemiology; D008562:Membrane Glycoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011991:Receptors, Virus / Q000235:genetics*; D016036:Seroepidemiologic Studies
chemical_list: C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus