title: Photoacoustic and ultrasound dual-modality imaging of human peripheral joints.
abstract: A photoacoustic (PA) and ultrasound (US) dual modality system, for imaging human peripheral joints, is introduced. The system utilizes a commercial US unit for both US control imaging and PA signal acquisition. Preliminary in vivo evaluation of the system, on normal volunteers, revealed that this system can recover both the structural and functional information of intra- and extra-articular tissues. Confirmed by the control US images, the system, on the PA mode, can differentiate tendon from surrounding soft tissue based on the endogenous optical contrast. Presenting both morphological and pathological information in joint, this system holds promise for diagnosis and characterization of inflammatory joint diseases such as rheumatoid arthritis.
authors.affiliation: University of Michigan Medical School, Department of Radiology, Ann Arbor, Michigan 48109, USA.
authors.forename: Guan
authors.initials: G
authors.lastname: Xu
authors.forename: Justin R
authors.initials: JR
authors.lastname: Rajian
authors.forename: Gandikota
authors.initials: G
authors.lastname: Girish
authors.forename: Mariana J
authors.initials: MJ
authors.lastname: Kaplan
authors.forename: J Brian
authors.initials: JB
authors.lastname: Fowlkes
authors.forename: Paul L
authors.initials: PL
authors.lastname: Carson
authors.forename: Xueding
authors.initials: X
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D061088:Photoacoustic Techniques / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*