title: Role of ventral subiculum in context-induced reinstatement of heroin seeking in rats.
abstract: In rats, reexposure to heroin-paired contexts after extinction of lever responding in a different context reinstates heroin seeking. Previous reports indicate that ventral hippocampus/Ca1 region plays a critical role in cocaine-, cue- and context-induced reinstatement of cocaine seeking. Here, we examined whether ventral subiculum, the output region of ventral hippocampus, is involved in context-induced reinstatement of heroin seeking. We found that reversible inactivation of ventral subiculum, but not posterior Ca1, with the gamma-aminobutyric acid agonists muscimol + baclofen decreased context-induced reinstatement of heroin seeking. Our findings, together with previous studies on cocaine seeking, indicate a critical role of ventral subiculum in context-induced relapse across drug classes.
authors.affiliation: Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, MD, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Bossert
authors.forename: Anna L
authors.initials: AL
authors.lastname: Stern
mesh_terms: D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D003463:Cues; D058999:Drug-Seeking Behavior / Q000187:drug effects; D005108:Extinction, Psychological / Q000187:drug effects; D058785:GABA-A Receptor Agonists / Q000494:pharmacology; D003932:Heroin / Q000494:pharmacology; D006556:Heroin Dependence / Q000503:physiopathology*; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D009118:Muscimol / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology; D051381:Rats; D012008:Recurrence; D012646:Self Administration
chemical_list: D058785:GABA-A Receptor Agonists; D009294:Narcotics; D009118:Muscimol; D003932:Heroin; D001418:Baclofen