title: Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.
abstract: Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer's disease and other tauopathies. Here in, we describe the first human brain images with [F-18]-T807.
authors.affiliation: Siemens Molecular Imaging, Inc., Culver City, CA 90230, USA.
authors.forename: David T
authors.initials: DT
authors.lastname: Chien
authors.forename: Shadfar
authors.initials: S
authors.lastname: Bahri
authors.forename: A Katrin
authors.initials: AK
authors.lastname: Szardenings
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Walsh
authors.forename: Fanrong
authors.initials: F
authors.lastname: Mu
authors.forename: Min-Ying
authors.initials: MY
authors.lastname: Su
authors.forename: William R
authors.initials: WR
authors.lastname: Shankle
authors.forename: Arkadij
authors.initials: A
authors.lastname: Elizarov
authors.forename: Hartmuth C
authors.initials: HC
authors.lastname: Kolb
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism; D002243:Carbolines / Q000378:metabolism; D042241:Early Diagnosis; D005260:Female; D005462:Fluorine Radioisotopes / Q000378:metabolism; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation / Q000502:physiology; D049268:Positron-Emission Tomography / Q000379:methods*; D016875:tau Proteins / Q000378:metabolism
chemical_list: D002243:Carbolines; D005462:Fluorine Radioisotopes; C054369:MAPT protein, human; D016875:tau Proteins; C000591008:7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole