title: Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection.
abstract: OBJECTIVE
  Endoscopic submucosal dissection (ESD) is now accepted as a minimally invasive treatment for early gastric cancer (EGC). To our knowledge, however, the functional effects of ESD have not been determined in patients with EGC. We therefore investigated whether gastric motility was affected by ESD.
  
  
  METHODS
  Using the (13) C-octanoic acid breath test, gastric emptying of solid test meals was examined in 26 EGC patients and 18 healthy controls, with EGC patients assayed before and about 2 months after ESD. Based on (13) CO2 breath-excretion curves, the lag-phase time (T(lag) ), half-emptying time (T(1/2) ), and gastric emptying coefficient (GEC) were calculated as indices of gastric emptying.
  
  
  RESULTS
  In healthy controls, the mean T(lag), T(1/2), and GEC were 85.5 ± 4.9 min, 148.5 ± 8.0 min, and 3.01 ± 0.09 h, respectively. Before ESD, the mean T(lag) , T(1/2), and GEC in the EGC patients were 90.1 ± 5.5 min, 174.7 ± 10.4 min, 2.64 ± 0.08 h, respectively. GEC, but not T(lag) or T(1/2), differed significantly in the two groups, with gastric emptying slower in EGC patients than in controls. Relative to before ESD, the mean T(lag), T(1/2), and GEC in EGC patients after ESD were 109.2% ± 7.8%, 107.9% ± 9.6%, 108.4% ± 4.7%, respectively, indicating that ESD did not significantly affect any of these gastric emptying parameters in EGC patients.
  
  
  CONCLUSIONS
  ESD is an effective treatment for EGC both in preserving organs and gastric motility.
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Higuchi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Eikichi
authors.initials: E
authors.lastname: Ihara
authors.forename: Kazuya
authors.initials: K
authors.lastname: Akahoshi
authors.forename: Hirotada
authors.initials: H
authors.lastname: Akiho
authors.forename: Yorinobu
authors.initials: Y
authors.lastname: Sumida
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Motomura
authors.forename: Masaru
authors.initials: M
authors.lastname: Kubokawa
authors.forename: Tetsuhide
authors.initials: T
authors.lastname: Ito
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
mesh_terms: D000328:Adult; D000368:Aged; D001944:Breath Tests; D016022:Case-Control Studies; D004210:Dissection / Q000379:methods*; D005260:Female; D005746:Gastric Emptying; D005753:Gastric Mucosa / Q000601:surgery*; D005773:Gastroscopy; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome