title: Dextran stabilized iron oxide nanoparticles: synthesis, characterization and in vitro studies.
abstract: Iron oxide nanoparticles are one of the most important genres of nanoparticles with promise. Dextran, a stable biocompatible coating agent was employed in the synthesis of iron oxide nanoparticles in the presence of urea. The morphology of nanoparticles was confirmed by dynamic light scattering and transmission electron microscopy. These particles were also assessed for cytotoxicity, cellular uptake and cell adhesion in vitro using murine fibroblast cell line. The synthesized nanoparticles were superparamagnetic, possessed spherical shape with narrow size distribution and were found to be biocompatible and non-toxic. This study serves as a background for using DIONPs in further in vitro and in vivo studies with a long term goal of using it in biological applications.
authors.affiliation: Division of Toxicology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Thiruvananthapuram 695012, Kerala, India.
authors.forename: Sheeja Liza
authors.initials: SL
authors.lastname: Easo
authors.forename: P V
authors.initials: PV
authors.lastname: Mohanan
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D003911:Dextrans / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D005290:Ferric Compounds / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D051379:Mice; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000648:ultrastructure; D014508:Urea / Q000737:chemistry
chemical_list: D003911:Dextrans; D005290:Ferric Compounds; C000499:ferric oxide; D014508:Urea