title: Hypertriglyceridaemia-induced pancreatitis: a contributory role of capecitabine?
abstract: Capecitabine is an orally administered pro-drug of 5-fluorouracil that confers superior disease-free survival and presumably has a more favourable side-effect profile. Here we report on a patient who developed acute necrotising pancreatitis and very high triglyceride levels as well as hand-foot syndrome after receiving capecitabine for colonic cancer. Increased awareness of this potential side-effect and close monitoring of lipid levels may be warranted, especially in patients who have other conditions predisposing them to severe secondary hyperlipidaemia when using this drug.
authors.affiliation: Department of Medicine, Queen Elizabeth Hospital, Jordan, Hong Kong. chy618@ha.org.hk
authors.forename: H Y
authors.initials: HY
authors.lastname: Chan
authors.forename: C M
authors.initials: CM
authors.lastname: Ng
authors.forename: S C
authors.initials: SC
authors.lastname: Tiu
authors.forename: Angel O K
authors.initials: AO
authors.lastname: Chan
authors.forename: C C
authors.initials: CC
authors.lastname: Shek
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000069287:Capecitabine; D003110:Colonic Neoplasms / Q000188:drug therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D060831:Hand-Foot Syndrome / Q000209:etiology; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications*; D019283:Pancreatitis, Acute Necrotizing / Q000209:etiology* / Q000473:pathology; D014280:Triglycerides / Q000097:blood
chemical_list: D000964:Antimetabolites, Antineoplastic; D014280:Triglycerides; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil