title: Increased mean platelet volume and mean platelet volume/platelet count ratio in Korean patients with deep vein thrombosis.
abstract: The mean platelet volume (MPV) is a laboratory marker associated with platelet function and activity. Increased MPV in thromboembolic disease is considered an important risk factor. The aim of this study was to compare the MPV and MPV/platelet count (MPV/P) ratio between deep vein thrombosis (DVT) and control subjects. We retrospectively reviewed the medical records of patients (n = 91) admitted due to newly diagnosed DVT from December 2010 to March 2012. The control group (n = 311) underwent health screening at our Hospital. Median MPV was higher in DVT patients compared to controls (8.6 fl vs. 7.9 fl, p < 0.0001). The DVT patients also had a higher MPV/P ratio compared to the control group (0.0388 fl/(10(9)/l) vs. 0.0308 fl/(10(9)/l), p < 0.0001). MPV was inversely correlated with platelet count in DVT patients (correlation coefficient = -0.33, p = 0.001). Receiver operator characteristic analysis revealed that an MPV cutoff value of 8.2 fl provided 70.3% sensitivity and 72.7% specificity. An MPV/P cutoff value of 0.0363 fl/(10(9)/l) showed 60% sensitivity and 73% specificity. MPV and MPV/P ratio could be considered meaningful laboratory markers for the risk of DVT.
authors.affiliation: Department of Surgery, School of Medicine, Kyung Hee University , Seoul , Republic of Korea.
authors.forename: Jin Soo
authors.initials: JS
authors.lastname: Han
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Cho
authors.forename: Jin Hyun
authors.initials: JH
authors.lastname: Joh
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Ahn
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count; D012372:ROC Curve; D056910:Republic of Korea; D012189:Retrospective Studies; D020246:Venous Thrombosis / Q000097:blood*