title: [Pain in multimorbid internistic patients].
abstract: Pain and pain management in multimorbid patients is a subject which is mostly unknown. General rules in pain management like the WHO analgesic ladder and its recommendations are to be equally respected as with other patients. As multimorbidity is a common problem especially in the elderly population, some changes in physiology, pharmacodynamics and pharmacokinetics have to be taken into consideration. A careful and slow adoption of dosage leads to more safety and tolerability. Other main problems of multimorbidity are drug-drug, drug-disease or disease-disease interactions, which influence the choice of analgesic medication. As especially the number of drug-drug interactions is endless, available software is a valuable aid to become aware of interactions and help weight the compromises.
authors.affiliation: Klinik und Poliklinik für Innere Medizin, Universitätsspital Zürich. dominik.schneider@usz.ch
authors.forename: D
authors.initials: D
authors.lastname: Schneider
authors.forename: L
authors.initials: L
authors.lastname: Zimmerli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D059350:Chronic Pain / Q000188:drug therapy*; D003131:Combined Modality Therapy; D015897:Comorbidity; D004177:Dipyrone / Q000009:adverse effects / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D026741:Physical Therapy Modalities
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004177:Dipyrone