title: Heuristics for the Hodgkin-Huxley system.
abstract: Hodgkin and Huxley (HH) discovered that voltages control ionic currents in nerve membranes. This led them to describe electrical activity in a neuronal membrane patch in terms of an electronic circuit whose characteristics were determined using empirical data. Due to the complexity of this model, a variety of heuristics, including relaxation oscillator circuits and integrate-and-fire models, have been used to investigate activity in neurons, and these simpler models have been successful in suggesting experiments and explaining observations. Connections between most of the simpler models had not been made clear until recently. Shown here are connections between these heuristics and the full HH model. In particular, we study a new model (Type III circuit): It includes the van der Pol-based models; it can be approximated by a simple integrate-and-fire model; and it creates voltages and currents that correspond, respectively, to the h and V components of the HH system.
authors.affiliation: Courant Institute of Mathematical Sciences, 251 Mercer St., NY 10012, USA. frank.hoppensteadt@nyu.edu
authors.forename: Frank
authors.initials: F
authors.lastname: Hoppensteadt
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D055724:Electrophysiological Phenomena; D055641:Mathematical Concepts; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*