title: The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China.
abstract: V-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) has been reported to be somatically mutated in 19% of melanoma cases. To investigate the prevalence of ERBB4 mutations in melanoma patients from southern China, we analyzed 117 formalin-fixed, paraffin-embedded melanoma samples archived in the Sun Yat-sen University Cancer Center. A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform was used to screen for mutations. No ERBB4 hotspot mutations were detected. Our results indicate that ERBB4 mutations may play a limited role in melanomas in China; therefore, targeting the ERBB4 mutation in melanoma patients from southern China may not be a promising strategy.
authors.affiliation: Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China. zhangxsh@sysucc.org.cn
authors.forename: Qi-Ming
authors.initials: QM
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Yuan-Xiang
authors.initials: YX
authors.lastname: Guan
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
authors.forename: Xin-Chun
authors.initials: XC
authors.lastname: Chen
authors.forename: Ya
authors.initials: Y
authors.lastname: Ding
authors.forename: Xi-Zhi
authors.initials: XZ
authors.lastname: Wen
authors.forename: Rui-Qing
authors.initials: RQ
authors.lastname: Peng
authors.forename: Shu-Mei
authors.initials: SM
authors.lastname: Yan
authors.forename: Xiao-Shi
authors.initials: XS
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D005121:Extremities; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009092:Mucous Membrane; D009154:Mutation; D016612:Paraffin Embedding; D066247:Receptor, ErbB-4; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D004273:DNA, Neoplasm; C587689:ERBB4 protein, human; D066246:ErbB Receptors; D066247:Receptor, ErbB-4