title: BODIPY-modified Ru(II) arene complex--a new ligand dissociation mechanism and a novel strategy to red shift the photoactivation wavelength of anticancer metallodrugs.
abstract: A Ru(II) arene complex [(η(6)-p-cymene)Ru(bpy)(py-BODIPY)](PF(6))(2), where bpy is 2,2'-bipyridine and py-BODIPY is a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene dye containing a pyridine group at the 8-position, was designed and synthesized. BODIPY modification renders the monodentate pyridine ligand with long wavelength absorbing capability, and an absorption maximum at 504 nm. Upon selective irradiation of the absorption band of the py-BODIPY ligand, the dissociation of the monodentate ligand occurs efficiently, followed by substitution by 9-ethylguanine if it is present in the solution. The photoinduced ligand dissociation quantum yield was measured to be 4.1% at 480 nm. The photoinduced electron transfer from the BODIPY chromophore to the Ru(II) arene moiety plays an important role in the ligand dissociation. Such a photosensitization strategy can be utilized to develop novel anticancer metallodrugs that may respond to light in the phototherapeutic window (650-900 nm).
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Qian-Xiong
authors.initials: QX
authors.lastname: Zhou
authors.forename: Wan-Hua
authors.initials: WH
authors.lastname: Lei
authors.forename: Yuan-Jun
authors.initials: YJ
authors.lastname: Hou
authors.forename: Yong-Jie
authors.initials: YJ
authors.lastname: Chen
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Bao-Wen
authors.initials: BW
authors.lastname: Zhang
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D055668:Photochemical Processes; D012428:Ruthenium / Q000737:chemistry*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000970:Antineoplastic Agents; D001896:Boron Compounds; D008024:Ligands; D009942:Organometallic Compounds; D012428:Ruthenium