title: Case Report: Extreme Levels of Serum S-100B in a Patient with Chronic Subdural Hematoma.
abstract: The protein S-100B is a biomarker increasingly used within neurosurgery and neurointensive care. As a relatively sensitive, yet unspecific, indicator of CNS pathology, potential sources of error must be clearly understood when interpreting serum S-100B levels. This case report studied the course of a 46-year-old gentleman with a chronic subdural hemorrhage, serum S-100B levels of 22 μg/l, and a history of malignant melanoma. Both intra- and extra-cranial sources of S-100B are evaluated and imply an unclear contribution of several sources to the total serum concentration. Potential sources of error when interpreting serum concentrations of S-100B are discussed.
authors.affiliation: School of Medicine, The University of Manchester Manchester, UK.
authors.forename: Malin Elisabet
authors.initials: ME
authors.lastname: Persson
authors.forename: Eric Peter
authors.initials: EP
authors.lastname: Thelin
authors.forename: Bo-Michael
authors.initials: BM
authors.lastname: Bellander