title: Prostate cancer predicting factors: a preliminary report from Tehran.
abstract: OBJECTIVE
  To determine the probability of having prostate cancer (PCa) using the combination of serum level of prostate-specific antigen (PSA) and age.
  
  
  METHODS
  A total of 160 patients and 190 controls were enrolled in this hospital-based case-control study. Using a logistic regression model and the odds ratio of age and PSA level, the probability of PCa was estimated based on serum level of PSA and age of the participants.
  
  
  RESULTS
  The mean age of patients with PCa and benign prostatic hyperplasia (BPH) was 67.75 ± 8.81 and 62.07 ± 8.71 years, respectively (P < .000). Using univariate analysis, we found that increase in life decades of the cases almost doubles the risk of having PCa (odds ratio = 1.95; P = .00), and the probability of developing cancer may increase by 74% in ketchup consumers. After multiple variable regressions, it was revealed that the odds of developing PCa increase by 90% only for every decade, and other variables did not have any significant association with PCa.
  
  
  CONCLUSIONS
  In clinical practice, PSA level combined with the age at presentation can be used as predictors of PCa probability and the necessity of biopsy.
authors.affiliation: Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Gholam Reza
authors.initials: GR
authors.lastname: Pourmand
authors.forename: Farzad
authors.initials: F
authors.lastname: Allameh
authors.forename: Kazem
authors.initials: K
authors.lastname: Mohammad
authors.forename: Sanaz
authors.initials: S
authors.lastname: Dehghani
authors.forename: Bita
authors.initials: B
authors.lastname: Pourmand
authors.forename: Abdol Rasoul
authors.initials: AR
authors.lastname: Mehrsai
authors.forename: Seyed Hamed
authors.initials: SH
authors.lastname: Hosseini
mesh_terms: D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D004032:Diet; D055088:Early Detection of Cancer; D006801:Humans; D007492:Iran; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011336:Probability; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis*; D012372:ROC Curve; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen