title: Osseointegration of implants with dendrimers surface characteristics installed conventionally or with Piezosurgery®. A comparative study in the dog.
abstract: OBJECTIVE
  The first aim of the present experiment was to compare bone healing at implants installed in recipient sites prepared with conventional drills or a piezoelectric device. The second aim was to compare implant osseointegration onto surfaces with and without dendrimers coatings.
  
  
  METHODS
  Six Beagles dogs were used in this study. Five implants with two different surfaces, three with a ZirTi(®) surface (zirconia sand blasted, acid etched), and two with a ZirTi(®)-modified surface with dendrimers of phosphoserine and polylysine were installed in the right side of the mandible. In the most anterior region (P2, P3), two recipient sites were prepared with drills, and one implant ZirTi(®) surface and one coated with dendrimers implants were installed at random. In the posterior region (P4 and M1), three recipient sites were randomly prepared: two sites with a Piezosurgery(®) instrument and one site with drill and two ZirTi(®) surface and one coated with dendrimers implants installed. Three months after the surgery, the animals were sacrificed for histological analysis.
  
  
  RESULTS
  No complications occurred during the healing period. Three implants were found not integrated and were excluded from analysis. However, n = 6 was obtained. The distance IS-B at the buccal aspect was 2.2 ± 0.8 and 1.8 ± 0.5 mm, while IS-C was 1.5 ± 0.9 and 1.4 ± 0.6 mm at the Piezosurgery(®) and drill groups, respectively. Similar values were obtained between the dendrimers-coated and ZirTi(®) surface implants. The BIC% values were higher at the drill (72%) compared to the Piezosurgery(®) (67%) sites. The BIC% were also found to be higher at the ZirTi(®) (74%) compared to the dendrimers-coated (65%) implants, the difference being statistically significant.
  
  
  CONCLUSIONS
  This study has revealed that oral implants may osseointegrate equally well irrespective of whether their bed was prepared utilizing conventional drills with abundant cooling or Piezosurgery(®). Moreover, the surface coating of implants with dendrimers phosphoserine and polylysine did not improve osseointegration.
authors.affiliation: Faculty of Dentistry, University of Medical Science, La Habana, Cuba.
authors.forename: Franco
authors.initials: F
authors.lastname: Bengazi
authors.forename: Niklaus P
authors.initials: NP
authors.lastname: Lang
authors.forename: Elena
authors.initials: E
authors.lastname: Canciani
authors.forename: Paolo
authors.initials: P
authors.lastname: Viganò
authors.forename: Joaquin Urbizo
authors.initials: JU
authors.lastname: Velez
authors.forename: Daniele
authors.initials: D
authors.lastname: Botticelli
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D050091:Dendrimers / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D004285:Dogs; D020007:Implants, Experimental; D016348:Osseointegration; D059745:Piezosurgery; D013499:Surface Properties; D014025:Titanium; D014945:Wound Healing; D015040:Zirconium
chemical_list: D020099:Coated Materials, Biocompatible; D050091:Dendrimers; D015921:Dental Implants; D015040:Zirconium; D014025:Titanium