title: [Intrathecal immunoglobulin production in the diagnosis and differential diagnosis of multiple sclerosis].
abstract: The evaluation of diagnostic significance of different immunological tests for intrathecal immunoglobulin production is summarized on the historical basis of investigation of patients with inflammatory, demyelinating and other neurological disorders. The assessment of cerebrospinal fluid lost its previous significance in the 2010 revision of diagnostic criteria for multiple sclerosis. Nowadays, it is used only for the diagnosis of primary progressive multiple sclerosis. Nevertheless, the requirements of the analysis of the cerebrospinal fluid are increasing due to subtle, subclinical and atypical cases of multiple sclerosis as well as undetermined demyelinating disorders. Intrathecal humoral immune response may be pathogenic in multiple sclerosis as suggest immunological data and effectiveness of anti-B cells treatment. Based on these tests, it is useful, to differentiate subgroups of patients and to evaluate different effects of treatment in perspective.
authors.forename: N A
authors.initials: NA
authors.lastname: Totolian
authors.forename: A A
authors.initials: AA
authors.lastname: Gotovchikov
authors.forename: S V
authors.initials: SV
authors.lastname: Lapin
authors.forename: I V
authors.initials: IV
authors.lastname: Maksimov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Kodzaeva
authors.forename: L N
authors.initials: LN
authors.lastname: Prakhova
authors.forename: A G
authors.initials: AG
authors.lastname: Il'ves
authors.forename: A P
authors.initials: AP
authors.lastname: Skoromets
authors.forename: A A
authors.initials: AA
authors.lastname: Totolian
authors.forename: A A
authors.initials: AA
authors.lastname: Skoromets
mesh_terms: D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D056724:Immunity, Humoral; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D007159:Immunologic Tests; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000276:immunology; D012680:Sensitivity and Specificity
chemical_list: D007074:Immunoglobulin G