title: New indolocarbazoles from a mutant strain of the marine-derived actinomycete Streptomyces fradiae 007M135.
abstract: Fradcarbazoles A-C (1-3), three new indolocarbazoles, were isolated from a mutant strain of the marine-derived actinomycete Streptomyces fradiae 007M135. Their structures were established by spectroscopic analysis, quantum chemical calculation, CD spectra, and chemical transformation. Fradcarbazole A (1) possessed a unique skeleton consisting of a staurosporine core, a thiazole ring, and an indole fragment. Compounds 1-3 displayed significant cytotoxicity against HL-60, K562, A-549, and BEL-7402 cell lines and inhibitory effects on the kinase PKC-α with IC(50) values of 0.001-4.58 μM.
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.forename: Yibin
authors.initials: Y
authors.lastname: Zhuang
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Peipei
authors.initials: P
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Qi
authors.forename: Kangbo
authors.initials: K
authors.lastname: Gu
authors.forename: Daojing
authors.initials: D
authors.lastname: Zhang
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D051571:Protein Kinase C-alpha / Q000037:antagonists & inhibitors; D019311:Staurosporine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013844:Thiazoles; C578815:fradcarbazole A; C578816:fradcarbazole B; C578817:fradcarbazole C; D051571:Protein Kinase C-alpha; D019311:Staurosporine