title: Lung inflammation in COPD: why does it matter?
abstract: COPD is characterized by lung inflammation, which intensifies with disease progression. Recent studies suggest that COPD has multiple phenotypes, each with a distinct molecular pathway. Proteolytic enzymes may have a prominent role in the emphysematous phenotype, while nitric oxide pathways may be more relevant for pulmonary vessel remodelling in COPD. This article provides a synopsis of the possible role that lung inflammation plays in the pathogenesis of COPD.
authors.affiliation: UBC James Hogg Research Center, St. Paul's Hospital Vancouver, BC, Canada ; Division of Pulmonology, Department of Internal Medicine, Dongguk University Ilsan Hospital Goyang, South Korea.
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Oh
authors.forename: Don D
authors.initials: DD
authors.lastname: Sin