title: Early detection, early symptom progression and symptomatic remission after ten years in a first episode of psychosis study.
abstract: BACKGROUND
  Poor symptom outcome remains a challenge in psychosis: At least 50% of first-episode patients continue to have positive and/or negative symptoms after ten years.
  
  
  OBJECTIVE
  To investigate rates, early predictors and early symptom progression of long-term non-remitted psychosis in an early detection study.
  
  
  METHODS
  Symptomatic remission according to new international criteria was assessed in 174 patients at ten-year follow-up. Remitted and non-remitted patients were compared on early symptom progression, and logistic regression was applied to predict non-remission.
  
  
  RESULTS
  At ten years, 50% of patients were in symptomatic remission. Non-remission was predicted by positive symptoms at inclusion and during the first year of treatment. Of individual symptoms only hallucinations were significantly predictive of ten-year non-remission. Early symptom differences were not reflected by differences in treatment.
  
  
  CONCLUSIONS
  Long-term symptomatic non-remission is associated with early positive symptoms. More assertive intervention may be needed in patients who do not respond robustly in the first year of treatment, whether or not they have been detected "early".
authors.affiliation: Regional Centre for Clinical Research in Psychosis, Division of Psychiatry, Stavanger University Hospital, Norway, PO Box 8100, 4068 Stavanger, Norway. wenchetenvelden@mac.com
authors.forename: Wenche
authors.initials: W
authors.lastname: Ten Velden Hegelstad
authors.forename: Ulrik
authors.initials: U
authors.lastname: Haahr
authors.forename: Tor K
authors.initials: TK
authors.lastname: Larsen
authors.forename: Bjørn
authors.initials: B
authors.lastname: Auestad
authors.forename: Helene
authors.initials: H
authors.lastname: Barder
authors.forename: Julie
authors.initials: J
authors.lastname: Evensen
authors.forename: Inge
authors.initials: I
authors.lastname: Joa
authors.forename: Jan O
authors.initials: JO
authors.lastname: Johannessen
authors.forename: Johannes
authors.initials: J
authors.lastname: Langeveld
authors.forename: Ingrid
authors.initials: I
authors.lastname: Melle
authors.forename: Stein
authors.initials: S
authors.lastname: Opjordsmoen
authors.forename: Jan Ivar
authors.initials: JI
authors.lastname: Rossberg
authors.forename: Bjørn Rishovd
authors.initials: BR
authors.lastname: Rund
authors.forename: Erik
authors.initials: E
authors.lastname: Simonsen
authors.forename: Per
authors.initials: P
authors.lastname: Vaglum
authors.forename: Thomas
authors.initials: T
authors.lastname: McGlashan
authors.forename: Svein
authors.initials: S
authors.lastname: Friis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012074:Remission Induction; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult