title: Sesquiterpene and acetogenin derivatives from the marine red alga Laurencia okamurai.
abstract: In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A-D (1-4), a new chamigrane derivative, okamurene E (5), and a new C₁₂-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of bromobisabolane sesquiterpenes possessing a phenyl moiety among Laurencia-derived sesquiterpenes, while okamuragenin (6) was the first acetogenin aldehyde possessing a C₁₂-carbon skeleton. Each of the isolated compounds was evaluated for the brine shrimp (Artemia salina) lethal assay and 7-hydroxylaurene displayed potent lethality with LD₅₀ 1.8 μM.
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liang
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Li
authors.forename: Chuan-Ming
authors.initials: CM
authors.lastname: Cui
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Sun
authors.forename: Bin-Gui
authors.initials: BG
authors.lastname: Wang
mesh_terms: D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D000818:Animals; D001156:Artemia / Q000187:drug effects; D044722:Laurencia / Q000737:chemistry*; D007928:Lethal Dose 50; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D013057:Spectrum Analysis
chemical_list: D054378:Acetogenins; D012717:Sesquiterpenes