title: Palladium-catalyzed vinylation of aminals with simple alkenes: a new strategy to construct allylamines.
abstract: A novel, highly selective palladium-catalyzed vinylation reaction for the direct synthesis of allylic amines from styrenes and aminals has been established. The utility of this method was also demonstrated by the rapid synthesis of cinnarizine from aldehydes, amines, and simple alkenes in one-pot manner. Mechanistic studies suggested that the reaction proceeds through a valuable cyclometalated Pd(II) complex generated by the oxidative addition of aminal to a Pd(0) species.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China.
authors.forename: Yinjun
authors.initials: Y
authors.lastname: Xie
authors.forename: Jianhua
authors.initials: J
authors.lastname: Hu
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Wang
authors.forename: Chungu
authors.initials: C
authors.lastname: Xia
authors.forename: Hanmin
authors.initials: H
authors.lastname: Huang
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D000499:Allylamine / Q000138:chemical synthesis*; D002384:Catalysis; D002936:Cinnarizine / Q000138:chemical synthesis; D008958:Models, Molecular; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D020058:Styrene / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000475:Alkenes; D002936:Cinnarizine; D020058:Styrene; D000499:Allylamine; D010165:Palladium