title: Linking abnormal mitosis to the acquisition of DNA damage.
abstract: Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage and chromosome breaks. Consequently, deregulated cell division can devastate the integrity of the normal genome and unleash a variety of oncogenic stimuli that may promote transformation. Recent work has shed light on the mechanisms that link abnormal mitosis with the development of DNA damage, how cells respond to such affronts, and the potential impact on tumorigenesis.
authors.affiliation: Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. neil_ganem@dfci.harvard.edu
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Ganem
authors.forename: David
authors.initials: D
authors.lastname: Pellman
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002869:Chromosome Aberrations; D020090:Chromosome Segregation; D004249:DNA Damage; D042822:Genomic Instability / Q000235:genetics; D006801:Humans; D051379:Mice; D008938:Mitosis