title: A new dynamic model of three cell interactions for CTL responses.
abstract: The exact mechanisms of CD4 help in the generation of memory cytotoxic T lymphocytes (CTLs) remain largely illusive. We propose that dendritic cells (DCs) first interact with CD4(+) T cells, resulting in DC licensing and CD4(+) T-cell priming. Thereafter, CD8(+) T cells can receive stimulatory signals from DC-CD4(+) T-cell clusters and as well as individually from licensed DCs and primed CD4(+) T cells.
authors.affiliation: Research Unit; Saskatchewan Cancer Agency; Saskatoon, SK Canada ; Department of Oncology; University of Saskatchewan; Saskatoon, SK Canada.
authors.forename: Khawaja Ashfaque
authors.initials: KA
authors.lastname: Ahmed
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Jim
authors.initials: J
authors.lastname: Xiang