title: A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content.
abstract: BACKGROUND
  Genomic regions controlling abdominal fatness (AF) were studied in the Northeast Agricultural University broiler line divergently selected for AF. In this study, the chicken 60KSNP chip and extended haplotype homozygosity (EHH) test were used to detect genome-wide signatures of AF.
  
  
  RESULTS
  A total of 5357 and 5593 core regions were detected in the lean and fat lines, and 51 and 57 reached a significant level (P<0.01), respectively. A number of genes in the significant core regions, including RB1, BBS7, MAOA, MAOB, EHBP1, LRP2BP, LRP1B, MYO7A, MYO9A and PRPSAP1, were detected. These genes may be important for AF deposition in chickens.
  
  
  CONCLUSIONS
  We provide a genome-wide map of selection signatures in the chicken genome, and make a contribution to the better understanding the mechanisms of selection for AF content in chickens. The selection for low AF in commercial breeding using this information will accelerate the breeding progress.
authors.affiliation: Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture, Harbin, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Shou-Zhi
authors.initials: SZ
authors.lastname: Wang
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Da
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Xiao-Xiang
authors.initials: XX
authors.lastname: Hu
authors.forename: Yuan-Dan
authors.initials: YD
authors.lastname: Zhang
authors.forename: Yu-Xiang
authors.initials: YX
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Leng
authors.forename: Zhi-Quan
authors.initials: ZQ
authors.lastname: Tang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D050153:Abdominal Fat / Q000166:cytology*; D000818:Animals; D001947:Breeding; D002645:Chickens / Q000235:genetics* / Q000378:metabolism*; D005819:Genetic Markers / Q000235:genetics; D023281:Genomics; D006239:Haplotypes / Q000235:genetics; D040641:Quantitative Trait Loci / Q000235:genetics
chemical_list: D005819:Genetic Markers