title: Diabetes, impaired fasting glucose, and cognitive decline in a population of elderly community residents.
abstract: OBJECTIVE
  Diabetes and impaired fasting glucose, as well as cognitive impairment, are common in the elderly. Although several cross-sectional studies have demonstrated the influence of diabetes on cognitive impairment, only a few longitudinal studies have assessed the relationship between diabetes, impaired fasting glucose and cognitive decline in non-demented elderly community dwellers, by means of extensive neuropsychological batteries. The present study assesses the relationship between baseline diabetes, impaired fasting glucose (IFG) and 2- year evolution of memory, attention and executive performance in a sample of non-demented elderly subjects.
  
  
  METHODS
  
  
  
  METHODS
  Population-based cohort study [(PROgnostic indicator OF cardiovascular and cerebrovascular events (PROOF)].
  
  
  METHODS
  One hundred and sixty-three community dwellers aged 65 years without dementia at recruitment.
  
  
  METHODS
  Memory, attention and executive performance.
  
  
  RESULTS
  A significant association was observed between baseline diabetes mellitus and a higher 2-year decline in the Trial Making Test B and Stroop test exploring attention and executive function. This effect remained significant after adjusting for age, gender, education, anxiety and depressive symptoms, as well as other cardiovascular risk factors (F=2.41; p=0.007). Instead, no relationship was observed between IFG and cognitive decline.
  
  
  CONCLUSIONS
  Our study showed that, in a sample of elderly non-demented community dwellers, diabetes mellitus (but not IFG) is associated with a higher decline in selective attention and executive functioning. These results emphasize the importance of detecting and man- aging diabetes and impaired fasting glucose, in order to prevent cognitive impairment and dementia.
authors.affiliation: Centre Mémoire de Ressources et de Recherche, Neurology Unit, University Hospital of Saint-Etienne, Saint-Etienne, France. isabelle.rouch@chu-st-etienne.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rouch
authors.forename: Frédéric
authors.initials: F
authors.lastname: Roche
authors.forename: Virginie
authors.initials: V
authors.lastname: Dauphinot
authors.forename: Bernard
authors.initials: B
authors.lastname: Laurent
authors.forename: Catherine Thomas
authors.initials: CT
authors.lastname: Antérion
authors.forename: Sébastien
authors.initials: S
authors.lastname: Celle
authors.forename: Pierre
authors.initials: P
authors.lastname: Krolak-Salmon
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Barthélémy
mesh_terms: D000367:Age Factors; D000368:Aged; D001288:Attention / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism*; D003072:Cognition Disorders / Q000097:blood* / Q000523:psychology; D015331:Cohort Studies; D048909:Diabetes Complications / Q000097:blood* / Q000523:psychology; D003920:Diabetes Mellitus / Q000097:blood* / Q000523:psychology*; D005215:Fasting / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D017063:Outcome Assessment, Health Care; D012307:Risk Factors
chemical_list: D001786:Blood Glucose