title: [Forensic application of investigator HDplex kit in Han nationality of Eastern China].
abstract: OBJECTIVE
  To investigate the genetic data of 12 autosomal STR loci included in Investigator HDplex kit and to evaluate its forensic application in Han nationality of Eastern China.
  
  
  METHODS
  A total of 484 unrelated healthy individuals in Han nationality of Eastern China were investigated with Investigator HDplex kit. Allele frequencies, population genetics parameters and linkage disequilibrium information of the 12 autosomal STR loci were statistically analyzed.
  
  
  RESULTS
  No deviations from Hardy-Weinberg equilibrium were detected and all loci were independent form each other within the studied 484 unrelated healthy individuals. DP values of the 12 autosomal STR loci were all above 0.8, and CDP was 0.999 999 999 92. The cumulative probability of paternity exclusion in duo and in trio were 0.999 82 and 0.999 998 6, respectively.
  
  
  CONCLUSIONS
  Investigator HDplex kit with 12 highly polymorphic STR loci in Han nationality of Eastern China could be used effectively for forensic DNA genotyping.
authors.affiliation: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China, Shanghai 200063, China. zsh-daisy@163.com
authors.forename: Su-hua
authors.initials: SH
authors.lastname: Zhang
authors.forename: Zhe-ren
authors.initials: ZR
authors.lastname: Zhang
authors.forename: Kuan
authors.initials: K
authors.lastname: Sun
authors.forename: Zhen-min
authors.initials: ZM
authors.lastname: Zhao
authors.forename: Cheng-tao
authors.initials: CT
authors.lastname: Li
mesh_terms: D000483:Alleles; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D002681:China; D005006:Ethnicity / Q000235:genetics; D053803:Forensic Genetics / Q000379:methods*; D005787:Gene Frequency; D056426:Genetic Loci / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic; D011933:Reagent Kits, Diagnostic
chemical_list: D005819:Genetic Markers; D011933:Reagent Kits, Diagnostic