title: Combined use of 18F-FDG PET/CT, DW-MRI, and DCE-MRI in treatment response for preoperative chemoradiation therapy in locally invasive rectal cancers.
abstract: We investigated if 18F-FDG PET/CT, DW-MRI, and DCE-MRI are able to predict preoperative chemoradiation therapy (CRT) response in patients with T3-4 rectal adenocarcinomas. MRI and PET/CT scans were performed within 1 week, at baseline, early midtreatment (2 weeks of CRT), and posttreatment (6 weeks after completing CRT). Responders (n = 4) and nonresponders (n = 4) were defined according to tumor regression grade by histology. Only SUVmax (P = 0.030) at early midtreatment could significantly differentiate between responders and nonresponders, suggesting that 18F-FDG PET/CT may be effective to predict early treatment response compared with DW-MRI and DCE-MRI in T3-4 rectal cancer.
authors.affiliation: Department of Diagnostic Radiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Gu
authors.forename: Pek-Lan
authors.initials: PL
authors.lastname: Khong
authors.forename: Silun
authors.initials: S
authors.lastname: Wang
authors.forename: Wailun
authors.initials: W
authors.lastname: Law
authors.forename: Tao
authors.initials: T
authors.lastname: Chan
authors.forename: Tony W H
authors.initials: TW
authors.lastname: Shek
authors.forename: Rico
authors.initials: R
authors.lastname: Liu
authors.forename: Jingbo
authors.initials: J
authors.lastname: Zhang
mesh_terms: D059248:Chemoradiotherapy; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D019788:Fluorodeoxyglucose F18; D006801:Humans; D064847:Multimodal Imaging; D009361:Neoplasm Invasiveness; D049268:Positron-Emission Tomography; D057234:Preoperative Period; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D019788:Fluorodeoxyglucose F18