title: [The influence of rotavirus vaccinations on the risk of gastrointestinal infections in children. Methods and preliminary results].
abstract: The gastrointestinal infection in infants are the significant health and epidemiological issue. The voluntary rotavirus vaccines was included to Polish vaccination schedule in 2007.
  
  
  OBJECTIVE
  Aim of the study was the assessment of rotaviruses vaccines effectiveness in prevention of rotavirus gastrointestinal infections requiring hospitalization and the influence or these vaccinations on the risk of gastrointestinal outpatient infections. The additional aim of the study was determine the incidence of adverse events following immunization caused by rotavirus vaccinations and comparison of both vaccines--Rotarix and RotaTeq with respect to the mentioned objectives.
  
  
  METHODS
  The retrospective cohort study was designed to achieve the aims of study. The study cohort included infants from Malopolska Voivodeship vaccinated with rotavirus vaccine in 2007-2008 and eligible matched unvaccinated children. The preliminary study was conducted in 2011.
  
  
  RESULTS
  The cohort study included 74 vaccinated and 74 unvaccinated infants. The preliminary analysis revealed that infants vaccinated against rotavirus had 40% lower risk to be affected by gastrointestinal infections in comparison to unvaccinated children. Nevertheless the results were not statistically significant owing to the scarce number of infants in pilot study group (95% CI: 0,27-1,30).
  
  
  CONCLUSIONS
  The preliminary results indicates, that the rotavirus vaccines have the positive influence on the decrease risk of gastrointestinal infections in children up to 2 years of years but the evidence is not sufficient yet, to be conclusive. The ongoing survey is given the possibility to gain the bigger cohort under study and to attain the presumed objectives.
authors.affiliation: Katedra Epidemiologii i Medycyny Zapobiegawczej, Uniwersytet Jagiellotiski, Collegium Medicum. dorota.mrozek-budzyn@uj.edu.pl
authors.forename: Dorota
authors.initials: D
authors.lastname: Mrozek-Budzyn
authors.forename: Kiełtyka
authors.initials: K
authors.lastname: Agnieszka
authors.forename: Renata
authors.initials: R
authors.lastname: Majewska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Augustyniak
mesh_terms: D015331:Cohort Studies; D004196:Disease Outbreaks / Q000517:prevention & control*; D005260:Female; D005767:Gastrointestinal Diseases / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D017589:Immunization Programs; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011044:Poland / Q000453:epidemiology; D015397:Program Evaluation; D012189:Retrospective Studies; D012306:Risk; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000009:adverse effects / Q000145:classification / Q000276:immunology*
chemical_list: D022243:Rotavirus Vaccines