title: Synthesis and antiradical/antioxidant activities of caffeic acid phenethyl ester and its related propionic, acetic, and benzoic acid analogues.
abstract: Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect of the presence of the double bond and of the conjugated system on the antioxidant effect is evaluated with the analogues obtained from  3-(3,4-dihydroxyphenyl) propanoic acid. Those obtained from 2-(3,4-dihydroxyphenyl) acetic acid and 3,4-dihydroxybenzoic acid allow the evaluation of the effect of the presence of two carbons between the carbonyl and aromatic system.
authors.affiliation: Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada.
authors.forename: Luc M
authors.initials: LM
authors.lastname: LeBlanc
authors.forename: Aurélie F
authors.initials: AF
authors.lastname: Paré
authors.forename: Jacques
authors.initials: J
authors.lastname: Jean-François
authors.forename: Martin J G
authors.initials: MJ
authors.lastname: Hébert
authors.forename: Marc E
authors.initials: ME
authors.lastname: Surette
authors.forename: Mohamed
authors.initials: M
authors.lastname: Touaibia
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry; D019817:Benzoic Acid / Q000737:chemistry; D002109:Caffeic Acids / Q000138:chemical synthesis / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011422:Propionates / Q000737:chemistry; D011429:Propolis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D002109:Caffeic Acids; D011422:Propionates; D002244:Carbon; D019817:Benzoic Acid; D011429:Propolis; C055494:caffeic acid phenethyl ester; C029658:propionic acid; D010626:Phenylethyl Alcohol; D019342:Acetic Acid