title: Application of data fusion in human health risk assessment for hydrocarbon mixtures on contaminated sites.
abstract: The exposure and toxicological data used in human health risk assessment are obtained from diverse and heterogeneous sources. Complex mixtures found on contaminated sites can pose a significant challenge to effectively assess the toxicity potential of the combined chemical exposure and to manage the associated risks. A data fusion framework has been proposed to integrate data from disparate sources to estimate potential risk for various public health issues. To demonstrate the effectiveness of the proposed data fusion framework, an illustrative example for a hydrocarbon mixture is presented. The Joint Directors of Laboratories Data Fusion architecture was selected as the data fusion architecture and Dempster-Shafer Theory (DST) was chosen as the technique for data fusion. For neurotoxicity response analysis, neurotoxic metabolites toxicological data were fused with predictive toxicological data and then probability-boxes (p-boxes) were developed to represent the toxicity of each compound. The neurotoxic response was given a rating of "low", "medium" or "high". These responses were then weighted by the percent composition in the illustrative F1 hydrocarbon mixture. The resulting p-boxes were fused according to DST's mixture rule of combination. The fused p-boxes were fused again with toxicity data for n-hexane. The case study for F1 hydrocarbons illustrates how data fusion can help in the assessment of the health effects for complex mixtures with limited available data.
authors.affiliation: School of Engineering, Okanagan Campus, The University of British Columbia, 3333 University Way, Kelowna, BC V1V 1V7, Canada. Electronic address: radyck@interchange.ubc.ca.
authors.forename: Roberta
authors.initials: R
authors.lastname: Dyck
authors.forename: M Shafiqul
authors.initials: MS
authors.lastname: Islam
authors.forename: Amin
authors.initials: A
authors.lastname: Zargar
authors.forename: Asish
authors.initials: A
authors.lastname: Mohapatra
authors.forename: Rehan
authors.initials: R
authors.lastname: Sadiq
mesh_terms: D045424:Complex Mixtures / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D003627:Data Interpretation, Statistical; D004785:Environmental Pollutants / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D006801:Humans; D006838:Hydrocarbons / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D008962:Models, Theoretical; D018570:Risk Assessment / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D045424:Complex Mixtures; D004785:Environmental Pollutants; D006838:Hydrocarbons