title: Measurement of the nonlinear optical response of low-density lipoprotein solutions from patients with periodontitis before and after periodontal treatment: evaluation of cardiovascular risk markers.
abstract: The Z-Scan (ZS) technique in the thermal regime has been used to measure the nonlinear optical response of low-density lipoprotein (LDL). The ZS technique is carried out in LDL from 40 patients with chronic periodontitis before and after three, six, and 12 months of periodontal treatment. Clinical parameters such as probing depths, bleeding on probing, total and differential white blood cells counts, lipid profiles, cytokine levels, and antibodies against oxidized LDL are also determined and compared over time. Before the treatment, the ZS experimental results reveal that the LDL particles of these patients are heavily modified. Only after 12 months of the periodontal treatment, the ZS results obtained reveal behavioral characteristics of healthy particles. This conclusion is also supported by complementary laboratorial analysis showing that the periodontal treatment induces systemic changes in several inflammatory markers.
authors.affiliation: University of São Paulo, Institute of Biomedical Sciences, SP, Brazil. monteiroam@usp.br
authors.forename: Andréa M
authors.initials: AM
authors.lastname: Monteiro
authors.forename: Maria A N
authors.initials: MA
authors.lastname: Jardini
authors.forename: Viviana
authors.initials: V
authors.lastname: Giampaoli
authors.forename: Sarah
authors.initials: S
authors.lastname: Alves
authors.forename: Antônio M
authors.initials: AM
authors.lastname: Figueiredo Neto
authors.forename: Magnus
authors.initials: M
authors.lastname: Gidlund
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D055113:Chronic Periodontitis / Q000097:blood* / Q000150:complications / Q000628:therapy; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D055620:Optical Phenomena; D010084:Oxidation-Reduction; D011446:Prospective Studies; D012307:Risk Factors; D012996:Solutions
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D008077:Lipoproteins, LDL; D012996:Solutions; C099252:oxidized low density lipoprotein