title: Ryanodine receptors, calcium signaling, and regulation of vascular tone in the cerebral parenchymal microcirculation.
abstract: The cerebral blood supply is delivered by a surface network of pial arteries and arterioles from which arise (parenchymal) arterioles that penetrate into the cortex and terminate in a rich capillary bed. The critical regulation of CBF, locally and globally, requires precise vasomotor regulation of the intracerebral microvasculature. This vascular region is anatomically unique as illustrated by the presence of astrocytic processes that envelope almost the entire basolateral surface of PAs. There are, moreover, notable functional differences between pial arteries and PAs. For example, in pial VSMCs, local calcium release events ("calcium sparks") through ryanodine receptor (RyR) channels in SR membrane activate large conductance, calcium-sensitive potassium channels to modulate vascular diameter. In contrast, VSMCs in PAs express functional RyR and BK channels, but under physiological conditions, these channels do not oppose pressure-induced vasoconstriction. Here, we summarize the roles of ryanodine receptors in the parenchymal microvasculature under physiologic and pathologic conditions, and discuss their importance in the control of CBF.
authors.affiliation: Department of Pharmacology, College of Medicine, University of Vermont, Burlington, Vermont, USA. f.dabertrand@gmail.com
authors.forename: Fabrice
authors.initials: F
authors.lastname: Dabertrand
authors.forename: Mark T
authors.initials: MT
authors.lastname: Nelson
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Brayden
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D008833:Microcirculation / Q000502:physiology*; D009129:Muscle Tonus / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel