title: Carrier molecules for use in veterinary vaccines.
abstract: The practice of immunization of animals and humans has been carried out for centuries and is generally accepted as the most cost effective and sustainable method of infectious disease control. Over the past 20 years there have been significant changes in our ability to produce antigens by conventional extraction and purification, recombinant DNA and synthesis. However, many of these products need to be combined with carrier molecules to generate optimal immune responses. This review covers selected topics in the development of carrier technologies for use in the veterinary vaccine field, including glycoconjugate and peptide vaccines, microparticle and nanoparticle formulations, and finally virus-like particles.
authors.affiliation: Vaccine and Infectious Disease Organization - International Vaccine Centre, University of Saskatchewan, Saskatoon, SK, Canada.
authors.forename: Volker
authors.initials: V
authors.lastname: Gerdts
authors.forename: George
authors.initials: G
authors.lastname: Mutwiri
authors.forename: James
authors.initials: J
authors.lastname: Richards
authors.forename: Sylvia
authors.initials: S
authors.lastname: van Drunen Littel-van den Hurk
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Potter
mesh_terms: D000818:Animals; D006001:Glycoconjugates / Q000276:immunology* / Q000627:therapeutic use; D053758:Nanoparticles / Q000737:chemistry*; D014611:Vaccination / Q000662:veterinary*; D014612:Vaccines / Q000737:chemistry / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000276:immunology; D022223:Vaccines, Subunit / Q000276:immunology*; D058425:Vaccines, Virus-Like Particle / Q000276:immunology*
chemical_list: D006001:Glycoconjugates; D014612:Vaccines; D018074:Vaccines, Conjugate; D022223:Vaccines, Subunit; D058425:Vaccines, Virus-Like Particle