title: Substitution effect on the one- and two-photon sensitivity of DMAQ "caging" groups.
abstract: The systematic SAR study of a "caging" group showed a strong influence of the position of the donor dimethylamino group on the efficiency of photolysis of the DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease of l-glutamate by the most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited by glutamate photoreleased from the widely used MNI-caged glutamate.
authors.affiliation: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, France.
authors.forename: Morgane
authors.initials: M
authors.lastname: Petit
authors.forename: Christine
authors.initials: C
authors.lastname: Tran
authors.forename: Thomas
authors.initials: T
authors.lastname: Roger
authors.forename: Thibault
authors.initials: T
authors.lastname: Gallavardin
authors.forename: Hamid
authors.initials: H
authors.lastname: Dhimane
authors.forename: Francisco
authors.initials: F
authors.lastname: Palma-Cerda
authors.forename: Mireille
authors.initials: M
authors.lastname: Blanchard-Desce
authors.forename: Francine C
authors.initials: FC
authors.lastname: Acher
authors.forename: David
authors.initials: D
authors.lastname: Ogden
authors.forename: Peter I
authors.initials: PI
authors.lastname: Dalko
mesh_terms: D005971:Glutamates / Q000737:chemistry*; D015394:Molecular Structure; D010782:Photolysis; D017785:Photons; D011804:Quinolines / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D005971:Glutamates; D011804:Quinolines