title: Association of SOD2, GPX1, CAT, and TNF genetic polymorphisms with oxidative stress, neurochemistry, psychopathology, and extrapyramidal symptoms in schizophrenia.
abstract: There is a growing body of evidence confirming the involvement of oxidative stress and inflammation in pathogenesis of schizophrenia. Inter-individual variation in antioxidant capacity caused by different genetic profile could potentially influence patient's susceptibility to oxidative damage. In this study we evaluated the polymorphisms of manganese superoxide dismutase SOD2Val16Ala, glutathione peroxidase GPX1Pro200Leu, catalase CAT-262C>T and CATc.66+78C>T, and tumour necrosis factor-alpha TNF-308G>A by assessing their association with biomarkers of oxidative stress, neurochemistry, psychopathology of schizophrenia and extrapyramidal symptoms in Caucasian schizophrenia patients treated with haloperidol depot. TNF-308G>A was associated with the increased risk of parkinsonism. No major role of polymorphism of SOD2Val16Ala, CAT-262C>T nor GPX1Pro200Leu in psychopathology of schizophrenia or extrapyramidal symptoms was observed. SOD2Val16Ala polymorphism was associated with dopamine plasma concentration and blood concentration ratio between reduced and oxidised form of glutathione, while GPX1Pro200Leu was related with concentration of reduced glutathione. CATc.66+78C>T was associated with noradrenaline plasma concentration and PANSS negative score. PANSS positive and general scores, were associated with the increased risk of tardive dyskinesia. PANSS positive, negative, and general scores, and GAF score were all associated with the increased risk of akathisia.
authors.affiliation: Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.
authors.forename: Marija
authors.initials: M
authors.lastname: Bošković
authors.forename: Tomaž
authors.initials: T
authors.lastname: Vovk
authors.forename: Marko
authors.initials: M
authors.lastname: Saje
authors.forename: Katja
authors.initials: K
authors.lastname: Goričar
authors.forename: Vita
authors.initials: V
authors.lastname: Dolžan
authors.forename: Blanka
authors.initials: B
authors.lastname: Kores Plesničar
authors.forename: Iztok
authors.initials: I
authors.lastname: Grabnar
mesh_terms: D000328:Adult; D000368:Aged; D001480:Basal Ganglia Diseases / Q000235:genetics* / Q000378:metabolism; D002374:Catalase / Q000235:genetics*; D004298:Dopamine / Q000097:blood; D005260:Female; D005787:Gene Frequency / Q000502:physiology; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D011110:Polymorphism, Genetic / Q000235:genetics; D011599:Psychopathology; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D000094765:Glutathione Peroxidase GPX1; D000099156:Superoxide Dismutase 2
chemical_list: D002374:Catalase; D004298:Dopamine; D005978:Glutathione; D005979:Glutathione Peroxidase; D009638:Norepinephrine; D013482:Superoxide Dismutase; D014409:Tumor Necrosis Factor-alpha; D000094765:Glutathione Peroxidase GPX1; D000099156:Superoxide Dismutase 2; C577219:CAT protein, human; C000722067:GPX1 protein, human