title: Open-angle glaucoma in Filipino and white Americans: a comparative study.
abstract: BACKGROUND
  To compare the frequency of open-angle glaucoma (OAG) subtypes between Filipino and white Americans in a general ophthalmology clinic population.
  
  
  METHODS
  In this retrospective cross-sectional epidemiologic study with prospective sampling, medical charts of 1113 patients aged 40 years or older (513 Filipinos, 600 whites) seen in 2008 were randomly sampled from 2 private comprehensive ophthalmology clinics. Glaucoma was diagnosed based on optic nerve appearance, visual field defects, and other ocular findings using the International Society of Geographical and Epidemiological Ophthalmology (ISGEO) scheme. The normal-tension subtype of OAG [normal-tension glaucoma (NTG)] was defined by intraocular pressure ≤21 mm Hg as determined by review of medical records.
  
  
  RESULTS
  NTG comprised a greater proportion of all glaucomatous disease in Filipino subjects [Filipino (F) vs. white (W): 46.7% vs. 26.8%; P=0.02]. Filipinos were more commonly diagnosed with OAG and NTG than whites (F vs. W: OAG, 11.9% vs. 8.2%; NTG, 6.8% vs. 2.5%; P=0.04, 0.001, respectively). There was no significant difference in central corneal thickness between Filipino and white subjects with NTG (P=0.66).
  
  
  CONCLUSIONS
  Both OAG and NTG may be more common in Filipino Americans than in white Americans with the propensity for NTG being particularly high in the former relative to the latter group.
authors.affiliation: *Department of Ophthalmology, University of California San Francisco, San Francisco †Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto ‡Redwood Eye Center, Vallejo §Pacific Eye Specialists, Daly City, CA.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Sáles
authors.forename: Roland Y
authors.initials: RY
authors.lastname: Lee
authors.forename: Anthony K
authors.initials: AK
authors.lastname: Agadzi
authors.forename: Michael R
authors.initials: MR
authors.lastname: Hee
authors.forename: Kuldev
authors.initials: K
authors.lastname: Singh
authors.forename: Shan C
authors.initials: SC
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001213:Asian / Q000208:ethnology*; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000208:ethnology*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D057066:Low Tension Glaucoma / Q000208:ethnology*; D008297:Male; D008875:Middle Aged; D010679:Philippines / Q000208:ethnology; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D014481:United States / Q000453:epidemiology; D058609:Visual Field Tests; D044465:White People / Q000208:ethnology*