title: Amyloid and its association with default network integrity in Alzheimer's disease.
abstract: The purpose of this study was to investigate the association between functional connectivity and β-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN.
authors.affiliation: Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Sofie M
authors.initials: SM
authors.lastname: Adriaanse
authors.forename: Ernesto J
authors.initials: EJ
authors.lastname: Sanz-Arigita
authors.forename: Maja A A
authors.initials: MA
authors.lastname: Binnewijzend
authors.forename: Rik
authors.initials: R
authors.lastname: Ossenkoppele
authors.forename: Nelleke
authors.initials: N
authors.lastname: Tolboom
authors.forename: Daniëlle M E
authors.initials: DM
authors.lastname: van Assema
authors.forename: Alle Meije
authors.initials: AM
authors.lastname: Wink
authors.forename: Ronald
authors.initials: R
authors.lastname: Boellaard
authors.forename: Maqsood
authors.initials: M
authors.lastname: Yaqub
authors.forename: Albert D
authors.initials: AD
authors.lastname: Windhorst
authors.forename: Wiesje M
authors.initials: WM
authors.lastname: van der Flier
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Lammertsma
authors.forename: Serge A R B
authors.initials: SA
authors.lastname: Rombouts
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
authors.forename: Bart N M
authors.initials: BN
authors.lastname: van Berckel
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism / Q000502:physiology; D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D060825:Cognitive Dysfunction / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D059907:Functional Neuroimaging / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000378:metabolism / Q000503:physiopathology; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods*; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D013844:Thiazoles