title: Stent graft performance in the treatment of abdominal aortic aneurysms: the influence of compliance and geometry.
abstract: The long-term success of the endovascular procedure for the treatment of Abdominal Aortic Aneurysms (AAAs ) depends on the secure fixation of the proximal end and the geometry of the stent-graft (SG) device. Variations in SG types can affect proximal fixation and SG hemodynamics. Such hemodynamic variations can have a catastrophic effect on the vascular system and may result from a SG/arterial wall compliance mismatch and the sudden decrease in cross-sectional area at the bifurcation, which may result in decreased distal perfusion, increased pressure wave reflection and increased stress at the interface between the stented and non-stented portion of the vessel. To examine this compliance mismatch, a commercial SG device was tested experimentally under a physiological pressure condition in a silicone AAA model based on computed tomography scans. There was a considerable reduction in compliance of 54% and an increase in the pulse wave velocity of 21%, with a significant amount of the forward pressure wave being reflected. To examine the SG geometrical effects, a commercial bifurcated geometry was compared computationally and experimentally with a geometrical taper in the form of a blended section, which provided a smooth transition from the proximal end to both iliac legs. The sudden contraction of commercial SG at the bifurcation region causes flow separation within the iliac legs, which is known to cause SG occlusion and increased proximal pressure. The blended section along the bifurcation region promotes a greater uniformity of the fluid flow field within the distal legs, especially, during the deceleration phase with reduced boundary layer reversal. In order to reduce the foregoing losses, abrupt changes of cross-section should be avoided. Geometrical tapers could lead to improved clinical outcomes for AAA SGs.
authors.affiliation: Galway Medical Technologies Centre, Department of Mechanical and Industrial, Engineering, Galway Mayo Institute of Technology, Galway, Ireland.
authors.forename: Liam
authors.initials: L
authors.lastname: Morris
authors.forename: Florian
authors.initials: F
authors.lastname: Stefanov
authors.forename: Tim
authors.initials: T
authors.lastname: McGloughlin
mesh_terms: D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000503:physiopathology; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000503:physiopathology; D001027:Aortography; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis; D006801:Humans; D007083:Iliac Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D008955:Models, Cardiovascular; D015607:Stents; D013312:Stress, Physiological; D014057:Tomography, X-Ray Computed