title: C-reactive protein and preterm delivery: clues from placental findings and maternal weight.
abstract: To study the association between maternal C-reactive protein (CRP) and preterm delivery (PTD) pathways, CRP was measured in maternal plasma collected at mid-pregnancy (n = 1310). PTD was subdivided into spontaneous (sPTD) or medically indicated (MI-PTD). Histologic chorioamnionitis (HCA) was determined by placental histopathology (n = 1076). Adjusted CRP levels were elevated for sPTD (5.5 µg/mL) versus term deliveries (4.8 µg/mL) and higher in sPTD with HCA (6.3 µg/mL). After removing HCA, an interaction between body mass index (BMI) and sPTD in relation to CRP was noted. In BMI-stratified models, an association between CRP and sPTD among women with prepregnancy BMI >25 (8.9 µg/mL for sPTD; 7.2 µg/mL for term) was absent among women with lower BMI. We propose that this remaining association in overweight/obese women suggests that CRP may mark an obesity/inflammation PTD pathway that is distinct from the pathway indicated by HCA.
authors.affiliation: Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI 48824, USA.
authors.forename: Bertha L
authors.initials: BL
authors.lastname: Bullen
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Jones
authors.forename: Claudia B
authors.initials: CB
authors.lastname: Holzman
authors.forename: Yan
authors.initials: Y
authors.lastname: Tian
authors.forename: Patricia K
authors.initials: PK
authors.lastname: Senagore
authors.forename: Poul
authors.initials: P
authors.lastname: Thorsen
authors.forename: Kristin
authors.initials: K
authors.lastname: Skogstrand
authors.forename: David M
authors.initials: DM
authors.lastname: Hougaard
authors.forename: Alla
authors.initials: A
authors.lastname: Sikorskii
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001835:Body Weight; D002097:C-Reactive Protein / Q000032:analysis*; D002821:Chorioamnionitis / Q000097:blood / Q000473:pathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D047928:Premature Birth / Q000097:blood / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein