title: Equal performance of novel N-terminal proBNP (Cardiac proBNP®) and established BNP (Triage BNP®) point-of-care tests.
abstract: BACKGROUND
  Recently, a novel point-of-care test (POCT) for N-terminal proBNP (NTproBNP) has been introduced (Cardiac proBNP®, Roche).
  
  
  OBJECTIVE
  The aim was to compare the novel POCT for NTproBNP with the established POCT for BNP.
  
  
  METHODS
  NTproBNP and BNP were assessed in 222 individuals with chronic heart failure (n = 151) or controls (n = 71) with both POCTs.
  
  
  RESULTS
  NTproBNP and BNP were closely correlated upon regression analysis (r = 0.93; p < 0.01). NTproBNP and BNP were both correlated with ejection fraction and New York Heart Association stage. Receiver operating characteristic analysis yielded satisfying and equivalent predictive values for the detection of left ventricular dysfunction (ejection fraction <40%; NTproBNP: area under the curve 0.97; BNP: area under the curve 0.96; p > 0.05) and presence of New York Heart Association stage >2 (area under the curve 0.92 vs 0.91 for NT-proBNP and BNP, respectively; p > 0.05).
  
  
  CONCLUSIONS
  The NTproBNP POCT allows biochemical detection of heart failure with satisfactory predictive values, is equivalent to the BNP POCT and will improve near-patient testing.
authors.affiliation: Department of Cardiology, Klinik und Poliklinik fuer Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany. carsten.jungbauer@klinik.uniregensburg.de
authors.forename: Carsten G
authors.initials: CG
authors.lastname: Jungbauer
authors.forename: Bernhard
authors.initials: B
authors.lastname: Kaess
authors.forename: Stefan
authors.initials: S
authors.lastname: Buchner
authors.forename: Christoph
authors.initials: C
authors.lastname: Birner
authors.forename: Matthias
authors.initials: M
authors.lastname: Lubnow
authors.forename: Markus
authors.initials: M
authors.lastname: Resch
authors.forename: Kurt
authors.initials: K
authors.lastname: Debl
authors.forename: Monika
authors.initials: M
authors.lastname: Buesing
authors.forename: Rainer
authors.initials: R
authors.lastname: Zerback
authors.forename: Günter
authors.initials: G
authors.lastname: Riegger
authors.forename: Andreas
authors.initials: A
authors.lastname: Luchner
mesh_terms: D001774:Blood Chemical Analysis / Q000379:methods*; D004489:Edema, Cardiac / Q000150:complications; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D019095:Point-of-Care Systems; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain