title: microRNA-372 maintains oncogene characteristics by targeting TNFAIP1             and affects NFκB signaling in human gastric carcinoma cells.
abstract: Aberrant microRNA (miRNA) expression has been investigated in gastric cancer, which is one of the most common malignancies. However, the roles of miRNAs in gastric cancer remain largely unknown. In the present study, we found that microRNA-372 (miR-372) directly targets tumor necrosis factor, α-induced protein 1 (TNFAIP1), and is involved in the regulation of the NFκB signaling pathway. Furthermore, overexpression of TNFAIP1 induced changes in AGS cells similar to those in AGS cells treated with miR-372-ASO. Collectively, these findings demonstrate an oncogenic role for miR-372 in controlling cell growth and apoptosis through downregulation of TNFAIP1. This novel molecular basis provides new insights into the etiology of gastric cancer.
authors.affiliation: Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University, Changsha, Hunan 410081, P.R. China. zhouchang1972@126.com
authors.forename: Chang
authors.initials: C
authors.lastname: Zhou
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Li
authors.forename: Xiaoting
authors.initials: X
authors.lastname: Zhang
authors.forename: Xizhi
authors.initials: X
authors.lastname: Liu
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Tan
authors.forename: Celi
authors.initials: C
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D020413:3' Untranslated Regions; D048868:Adaptor Proteins, Signal Transducing; D017209:Apoptosis; D002277:Carcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D057809:HEK293 Cells; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009154:Mutation; D016328:NF-kappa B / Q000235:genetics; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D020413:3' Untranslated Regions; D048868:Adaptor Proteins, Signal Transducing; C561021:MIRN372 microRNA, human; D035683:MicroRNAs; D016328:NF-kappa B; D011506:Proteins; C115968:TNFAIP1 protein, human; D014409:Tumor Necrosis Factor-alpha