title: Feasibility of magnetic resonance electrical impedance tomography (MREIT) conductivity imaging to evaluate brain abscess lesion: in vivo canine model.
abstract: OBJECTIVE
  To show the feasibility of magnetic resonance electrical impedance tomography (MREIT) conductivity imaging in terms of its capability to provide new contrast information of abscess lesion and characterize time-course variations before and after the induction of brain abscess.
  
  
  METHODS
  Brain abscess was induced in healthy beagles by a direct inoculation method using Staphylococcus pseudintermedius. After the induction, four electrodes were attached on the head and the dog was placed inside the magnetic resonance imaging (MRI) bore. Using a current source, we injected a current of amplitude 5 mA and a pulse width of 81 msec. A multi-echo ICNE pulse sequence was used to obtain the magnetic flux density (Bz ) data.
  
  
  RESULTS
  The relative conductivity contrast ratios (rCCR, %) of abscess lesion were significantly changed by the postinduction time (P < 0.01). The rCCRs of central abscess lesions were higher than the surrounding area at 6, 12, and 18 hours (P < 0.01). Over 12 hours, the relationship between the induction time and rCCR showed a positive correlation followed by a negative correlation (P < 0.01).
  
  
  CONCLUSIONS
  We performed in vivo disease model animal experiments to validate the MREIT technique providing conductivity information of tissues in situ to be utilized in clinical applications.
authors.affiliation: Department of Biomedical Engineering, Kyung Hee University, Yongin, Korea.
authors.forename: Tong In
authors.initials: TI
authors.lastname: Oh
authors.forename: Woo Chul
authors.initials: WC
authors.lastname: Jeong
authors.forename: Alistair
authors.initials: A
authors.lastname: McEwan
authors.forename: Hee Myung
authors.initials: HM
authors.lastname: Park
authors.forename: Hyung Joong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Oh In
authors.initials: OI
authors.lastname: Kwon
authors.forename: Eung Je
authors.initials: EJ
authors.lastname: Woo
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D001922:Brain Abscess / Q000175:diagnosis* / Q000503:physiopathology*; D058266:Dielectric Spectroscopy / Q000379:methods*; D004285:Dogs; D004553:Electric Conductivity; D005240:Feasibility Studies; D005260:Female; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014054:Tomography / Q000379:methods*