title: Tracheoplasty using a metallic fusiform centrally-doubled coiled stent for a major tracheal defect in rabbits.
abstract: OBJECTIVE
  The long-term survival rate of rabbits treated with a fusiform metallic coil for a large tracheal wall defect is 60%. In the present study, the central half of a simple coil was covered by a double coil to prevent the ingrowth of the surrounding connective tissue and to provide a sutureless fixation of the coil to obtain a further increase in the survival rate.
  
  
  METHODS
  The anterior half of the tracheal wall was removed for a longitudinal length of 6 tracheal rings to make a large tracheal defect. Metallic coils were placed into the tracheal lumen through the wall defect. The doubly-coiled portion was designed to fit the length of the defect to eliminate the need for suture fixation. The survival at two months after the operation, endoscopic findings and histological changes were evaluated.
  
  
  RESULTS
  All 6 rabbits treated with a centrally-doubled coiled stent survived without major respiratory trouble for at least 2 months. Endoscopic examinations performed 1 month after the operation revealed an irregular coating of reddish granulation tissue inside the coil, and a wet portion was aspirated. The tracheal defect was replaced with fibrous tissue, but neither a complete epithelialization nor cartilage formation was observed.
  
  
  CONCLUSIONS
  These results suggest that the metallic coil was useful to obtain an improvement in the survival of rabbits with a large tracheal wall defect. Therefore, this new coil might be indicated for the treatment of tracheal wall defects.
authors.affiliation: Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori, Cyuo-ku, Niigata 951-8510, Japan. mkubota@med.niigata-u.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kubota
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Wakai
authors.forename: Naoki
authors.initials: N
authors.lastname: Okuyama
authors.forename: Kumiko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Kanako
authors.initials: K
authors.lastname: Sato
authors.forename: Kengo
authors.initials: K
authors.lastname: Nakaya
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Arai
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ohyama
mesh_terms: D000818:Animals; D001707:Biopsy, Needle; D001999:Bronchoscopy / Q000379:methods; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D008297:Male; D008670:Metals; D011474:Prosthesis Design; D011475:Prosthesis Failure; D011817:Rabbits; D011897:Random Allocation; D019651:Plastic Surgery Procedures / Q000379:methods* / Q000401:mortality; D018570:Risk Assessment; D015607:Stents; D015996:Survival Rate; D014135:Tracheal Stenosis / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D008670:Metals