title: Longevity and Patau syndrome: what determines survival?
abstract: The authors report of an 8-year-old girl with non-mosaic Patau syndrome. The median life expectancy of Patau syndrome is 7-10 days, and 90% die in the first year of life. Survival is often attributed to mosaicism and the severity of associated malformations. We delineate the developing phenotype and review the literature discussing potential contributory factors to longevity.
authors.affiliation: University College London, London, UK. s.peroos@doctors.org.uk
authors.forename: Sherina
authors.initials: S
authors.lastname: Peroos
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Forsythe
authors.forename: Jennifer Harriet
authors.initials: JH
authors.lastname: Pugh
authors.forename: Peter
authors.initials: P
authors.lastname: Arthur-Farraj
authors.forename: Deborah
authors.initials: D
authors.lastname: Hodes
mesh_terms: D002648:Child; D025063:Chromosome Disorders / Q000235:genetics*; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D005260:Female; D006801:Humans; D008136:Longevity / Q000235:genetics; D009030:Mosaicism; D010641:Phenotype; D014314:Trisomy / Q000235:genetics*; D000073839:Trisomy 13 Syndrome