title: Toward the total synthesis of haliclonin A: construction of a tricyclic substructure.
abstract: Three keys to success: A concise method for the construction of a tricyclic substructure (2) of haliclonin A (1) in racemic form is described (see figure). This synthesis features a new Pd-mediated chemoselective carbonyl-enone coupling reaction, an organocatalytic reaction, and a ring-closing metathesis reaction for the construction of the macrocyclic ring as key steps.
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, PR China.
authors.forename: Shi-Peng
authors.initials: SP
authors.lastname: Luo
authors.forename: Lian-Dong
authors.initials: LD
authors.lastname: Guo
authors.forename: Long-Hui
authors.initials: LH
authors.lastname: Gao
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.forename: Pei-Qiang
authors.initials: PQ
authors.lastname: Huang
mesh_terms: D003500:Cyclization; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003959:Diamines; D047028:Macrocyclic Compounds; C540232:haliclonin A