title: [Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro)].
abstract: In this work is presented the data on the variability of the functional characteristics of the chromosomes in the cells exposed by oligopeptide bioregulator - Prostamax from old individuals (75-86 years). Evaluated: the frequency of sister chromatid exchanges (SCE); Ag-positive NORs (in associations and nonassociations), as well as the variability of the structural C-pericentromeric heterochromatin. Prostamax changed the chromosomal parameters: 1) increased the frequency of SCE to 12,0±0,28 exchange in per cell (in intact cells - 5,9±0,2); 2) increased the frequency of Ag-positive NORs to 2.5 per cell (in intact cells - 0.95) 3) reduced in the frequency of large segments of the options from the pericentromeric heterochromatin for the 1st and 9th chromosomes.  Comparison of the results indicates the ability of Prostamax to decondensation, deheterchromatinization the chromatin during aging, and thus release by heterochromatinization repressed genes. On the other hand, the data obtained in this work suggest that the basis for the protective action of Prostamax its modifying effect on chromatin.
authors.forename: T A
authors.initials: TA
authors.lastname: Dzhokhadze
authors.forename: T Zh
authors.initials: TZh
authors.lastname: Buadze
authors.forename: M N
authors.initials: MN
authors.lastname: Gaĭozishvili
authors.forename: N A
authors.initials: NA
authors.lastname: Baratashvili
authors.forename: T A
authors.initials: TA
authors.lastname: Lezhava
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000235:genetics; D002478:Cells, Cultured; D006570:Heterochromatin / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D009697:Nucleolus Organizer Region / Q000187:drug effects / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D006570:Heterochromatin; D009842:Oligopeptides; C500342:Prostamax