title: Thymoma: a population-based study of the management and outcomes for the province of British Columbia.
abstract: BACKGROUND
  Thymomas are rare neoplasms with variable clinical behavior. Our primary study aim was to analyze treatment practices and outcomes in a population-based cohort of thymoma patients. We hypothesized that stage I and II thymomas would have high cure rates with resection and adjuvant radiation, whereas locally advanced cases would benefit from multimodality therapy.
  
  
  METHODS
  All patients, diagnosed with thymoma or thymic carcinoma in British Columbia between 1994 and 2009, were identified using the British Columbia Cancer Agency Registry. Chart review was used to collect demographic and treatment data. Detailed pathology review was performed using the World Health Organization classification.
  
  
  RESULTS
  One hundred and seventy-one patients were identified for analysis. The 5-year overall survival was 93.3%, 88.7%, 74.6%, 43.4% for stages I, II, III, and IV, respectively. Survival varied significantly among patients with thymoma compared with thymic carcinoma. In patients with stage II disease, adjuvant radiation did not confer an overall survival or recurrence-free survival benefit. Seventy-five patients had locally advanced disease. There was practice variation in treatment of these patients. Patients with thymoma undergoing trimodality treatment had a 5-year median overall survival of 80%, whereas patients with thymic carcinoma had poor outcomes despite aggressive treatment.
  
  
  CONCLUSIONS
  Survival rates in this population-based series were comparable to those in previously published reports. The ideal management of thymic tumors involves a multidisciplinary approach, particularly in locally advanced disease and selection of patients for adjuvant radiation therapy.
authors.affiliation: Department of British Columbia Cancer Agency, British Columbia, Canada.
authors.forename: Caroline
authors.initials: C
authors.lastname: Mariano
authors.forename: Diana N
authors.initials: DN
authors.lastname: Ionescu
authors.forename: Winson Y
authors.initials: WY
authors.lastname: Cheung
authors.forename: Rola H
authors.initials: RH
authors.lastname: Ali
authors.forename: Janessa
authors.initials: J
authors.lastname: Laskin
authors.forename: Ken
authors.initials: K
authors.lastname: Evans
authors.forename: Hannah
authors.initials: H
authors.lastname: Carolan
authors.forename: Nevin
authors.initials: N
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001955:British Columbia; D002277:Carcinoma / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D010257:Paraneoplastic Syndromes / Q000209:etiology; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D013934:Thymectomy; D013945:Thymoma / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D013953:Thymus Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D055815:Young Adult