title: Expression and phosphorylation of stathmin correlate with cell migration             in esophageal squamous cell carcinoma.
abstract: Microtubules play extensive roles in cellular processes, including cell             motility. Stathmin is an important protein which destabilizes microtubules. The             essential function of stathmin is closely associated with its phosphorylation             status. Stathmin is overexpressed in many human cancers and has a significant             relationship with clinical characteristics such as grade, tumor size and prognosis.             We demonstrated that stathmin was overexpressed in ESCC tissues using both 2-DE             and immunohistochemistry analysis. In addition, overexpression of stathmin was             significantly correlated with histological grade in ESCC. However, no correlation             was found with age, gender and lymph node metastasis. Knockdown of stathmin with             siRNA impaired cell migration in KYSE30 and KYSE410 cells. When EC0156 cells were             treated with paclitaxel, stathmin was stably phosphorylated and migration was             impaired. These observations suggest that stathmin may have a more important function             in ESCC development and migration. The present study provides further understanding             of the importance of stathmin in ESCC therapy or diagnosis.
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Sun
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Li-Shun
authors.initials: LS
authors.lastname: Wang
authors.forename: Xiao-Hang
authors.initials: XH
authors.lastname: Zhao
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D016009:Chi-Square Distribution; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D055785:Gene Knockdown Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D017239:Paclitaxel / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D034741:RNA, Small Interfering; D050777:Stathmin / Q000235:genetics / Q000378:metabolism*; D050257:Tubulin Modulators / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D034741:RNA, Small Interfering; D050777:Stathmin; D050257:Tubulin Modulators; D017239:Paclitaxel