title: Inhibitory effect of ellagitannin metabolites on IgE-mediated allergic responses in RBL-2H3 cells.
abstract: The effects of four ellagitannin metabolites (M1-M4) and ellagic acid on immunoglobulin E-mediated allergic responses in rat basophilic leukemia-2H3 cells were investigated. M1-M4 inhibited the antigen-induced degranulation and secretion of interleukin-4 and tumor necrosis factor-α, but ellagic acid only slightly did so under the same experimental conditions. M1 inhibited the activation of the mitogen-activated protein kinases in antigen-stimulated cells.
authors.affiliation: Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Okayama, Japan. naganot@mw.kawasaki-m.ac.jp
authors.forename: Takao
authors.initials: T
authors.lastname: Nagano
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Takeaki
authors.initials: T
authors.lastname: Okamoto
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D047348:Hydrolyzable Tannins / Q000378:metabolism* / Q000494:pharmacology*; D006967:Hypersensitivity / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D007073:Immunoglobulin E / Q000276:immunology*; D015847:Interleukin-4 / Q000378:metabolism; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D047348:Hydrolyzable Tannins; D014409:Tumor Necrosis Factor-alpha; C013515:ellagitannin; D015847:Interleukin-4; D007073:Immunoglobulin E