title: [Quality of life analysis of postmenopausal, early breast cancer patients treated with anastrozole (RADAR-II)].
abstract: Due to the recognition and diagnosis of breast cancer in increasingly early stages, quality of life becomes an important part of treatment beyond the efficacy indicators. In the scientific literature quality of life data related to adjuvant treament of early breast cancer is poorly represented. Our aim was collecting data to capture the changes in quality of life of postmenopausal, early breast cancer patients. This multicenter, prospective, observational, non-interventional study enrolled 1502 postmenopausal, early stage breast cancer patients. The answers to the QoL questionnaire were rated on a scale from 0 to 100. Overall the patients judged their working ability fairly negative at the start however, this parameter improved by the end of the survey. According to earlier studies the physical parameters deteriorated more significantly among patients belonging to the elderly (≥65 years) age group compared to younger patients. This correlation was confirmed by our study as well. Our results however are somewhat conflicting with the observations by Fehlauer et al (14) that younger patients show greater absolute and relative functional deterioration in their physical status compared to middle-aged or elderly patients. Fatigue appeared in the same rate among different age groups, while deterioration in vitality and daily functionality levels could persist for several years. Based on our findings the elderly patient's care needs special attention from treating personnel.
authors.affiliation: Onkológiai Intézet, Debreceni Egyetem, Debrecen, Hungary. horvathzsolt@med.unideb.hu
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Horváth
mesh_terms: D000328:Adult; D000368:Aged; D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D006304:Health Status; D006801:Humans; D006814:Hungary; D008875:Middle Aged; D009367:Neoplasm Staging; D009570:Nitriles / Q000627:therapeutic use*; D017060:Patient Satisfaction / Q000706:statistics & numerical data*; D017698:Postmenopause; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole