title: Is it really necessary to delay intranasal steroid treatment after FESS? An animal study.
abstract: OBJECTIVE
  The aim of this study is to investigate the effect of early intranasal steroid administration on wound healing after sinus surgery.
  
  
  METHODS
  Randomized, placebo-controlled, blinded animal study.
  
  
  METHODS
  Animal laboratory.
  
  
  METHODS
  Forty-two male New Zealand rabbits underwent bilateral 3-mm punch resection of the concha nasalis ventralis. The animals were divided into 3 groups: saline, late steroid, and early steroid. The saline group received saline drops, the late steroid group received saline drops for 7 days followed by intranasal mometasone furoate 50 µg/nostril/d, and the early steroid group received intranasal mometasone furoate (same dose) starting on postoperative day 1. The animals were sacrificed on postoperative days 10 and 21. Left nasal specimens were examined histopathologically with hematoxylin-eosin and matrix metalloproteinase-9 (MMP-9) stains. Right nasal specimens were examined with high-performance liquid chromatography, and hydroxyproline levels were measured as mg/g in wet tissue.
  
  
  RESULTS
  Late steroid and early steroid groups were similar with regard to MMP-9 staining on days 10 and 21. On day 10, the early steroid group revealed significantly intense MMP-9 staining when compared with the saline group, and the late steroid and early steroid groups revealed significant fibrosis when compared with the saline group. Hydroxyproline levels were similar in all groups on day 10. The early steroid group revealed significantly higher hydroxyproline levels when compared with the late steroid group on day 21.
  
  
  CONCLUSIONS
  Our findings showed that early intranasal steroid administration after sinus surgery in an animal model has no detrimental effects with regard to wound-healing parameters.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Bayraktar
authors.forename: Sinan
authors.initials: S
authors.lastname: Atmaca
authors.forename: Dilek
authors.initials: D
authors.lastname: Guvenc
authors.forename: M Onder
authors.initials: MO
authors.lastname: Karayigit
authors.forename: Enes
authors.initials: E
authors.lastname: Atmaca
authors.forename: Murat
authors.initials: M
authors.lastname: Yarim
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Aksoy
mesh_terms: D000281:Administration, Intranasal; D000704:Analysis of Variance; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004311:Double-Blind Method; D006416:Hematoxylin / Q000494:pharmacology; D006909:Hydroxyproline / Q000378:metabolism; D007124:Immunoenzyme Techniques; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000494:pharmacology; D000068656:Mometasone Furoate; D010256:Paranasal Sinuses / Q000601:surgery*; D011244:Pregnadienediols / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D018709:Statistics, Nonparametric; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D011244:Pregnadienediols; D000068656:Mometasone Furoate; D020780:Matrix Metalloproteinase 9; D006909:Hydroxyproline; D006416:Hematoxylin