title: Corticosteroids for the inflammatory response to cardiopulmonary bypass: an update.
abstract: Cardiac surgery and cardiopulmonary bypass are associated with an intense activation of the immune system. The systemic inflammatory response that develops in many cardiac surgical patients has the potential to lead to significant postoperative morbidity, and even mortality. Intraoperative corticosteroids are often used as prophylaxis for this systemic inflammatory response. This update provides a review of the existing evidence of the effects of corticosteroids on clinical outcomes after cardiopulmonary bypass, and combines this with emerging evidence from a recently published first large clinical trial of dexamethasone in cardiac surgery.
authors.affiliation: Department of Anesthesiology, Intensive Care & Emergency Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. stefandieleman@me.com
authors.forename: Jan M
authors.initials: JM
authors.lastname: Dieleman
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology; D009203:Myocardial Infarction / Q000150:complications* / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control*
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents