title: Cadmium-free quantum dots as time-gated bioimaging probes in highly-autofluorescent human breast cancer cells.
abstract: We report cadmium-free, biocompatible (Zn)CuInS(2) quantum dots with long fluorescence lifetimes as superior bioimaging probes using time-gated detection to suppress cell autofluorescence and improve the signal : background ratio by an order of magnitude. These results will be important for developing non-toxic fluorescence imaging probes for ultrasensitive biomedical diagnostics.
authors.affiliation: Department of Chemistry and Biochemistry, University of Arkansas, 345 N. Campus Drive, Fayetteville, AR 72701, USA.
authors.forename: Gopa
authors.initials: G
authors.lastname: Mandal
authors.forename: Molly
authors.initials: M
authors.lastname: Darragh
authors.forename: Y Andrew
authors.initials: YA
authors.lastname: Wang
authors.forename: Colin D
authors.initials: CD
authors.lastname: Heyes
mesh_terms: D000906:Antibodies / Q000276:immunology; D001943:Breast Neoplasms; D002104:Cadmium / Q000737:chemistry; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007204:Indium / Q000737:chemistry; D018613:Microscopy, Confocal; D045663:Quantum Dots; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000737:chemistry / Q000378:metabolism; D013455:Sulfur / Q000737:chemistry; D015032:Zinc / Q000737:chemistry
chemical_list: D000906:Antibodies; D002104:Cadmium; D003300:Copper; D005456:Fluorescent Dyes; D007204:Indium; D018719:Erb-b2 Receptor Tyrosine Kinases; D013455:Sulfur; D015032:Zinc