title: Immunohistochemical characterization of peroxisome proliferator-activated receptors in canine normal testis and testicular tumours.
abstract: Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Recent studies have demonstrated that PPARs regulate lipid metabolism and are expressed in various cancers. The aim of the present study was to investigate the expression of PPAR-α, -β and -γ in normal canine testicular tissue and canine testicular tumours (CTTs). Expression of PPAR-α, -β and -γ was greater (P <0.05) than in normal testicular tissue. PPARs were therefore induced in CTTs and they may play a role in the biology of these tumours.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Ondokuz Mayis University, TR-55139 Samsun, Turkey. msozmen@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Sozmen
authors.forename: Y B
authors.initials: YB
authors.lastname: Kabak
authors.forename: M Y
authors.initials: MY
authors.lastname: Gulbahar
authors.forename: A
authors.initials: A
authors.lastname: Gacar
authors.forename: M O
authors.initials: MO
authors.lastname: Karayigit
authors.forename: T
authors.initials: T
authors.lastname: Guvenc
authors.forename: M
authors.initials: M
authors.lastname: Yarim
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D007150:Immunohistochemistry; D008297:Male; D047492:Peroxisome Proliferator-Activated Receptors / Q000032:analysis / Q000096:biosynthesis*; D013736:Testicular Neoplasms / Q000378:metabolism / Q000662:veterinary*; D013737:Testis / Q000378:metabolism*
chemical_list: D047492:Peroxisome Proliferator-Activated Receptors