title: Management of cervicomediastinal neuroblastoma presenting with life-threatening tracheal obstruction in infancy.
abstract: The authors report on 3 infants below 6 months of age at diagnosis, with cervicomediastinal neuroblastoma who presented with life-threatening tracheal obstruction as an oncologic emergency. These neuroblastomas were characterized by favorable biology and chemoresistance. All initially grew rapidly before spontaneously regressing. Nerve injuries occurred in all patients as a result of tumor location. Maintenance of the airway until the expected spontaneous regression was a critical component in the management of these patients.
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Komuro
authors.forename: Noriko
authors.initials: N
authors.lastname: Hoshino
mesh_terms: D000402:Airway Obstruction / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008479:Mediastinal Neoplasms / Q000151:congenital / Q000473:pathology*; D009365:Neoplasm Regression, Spontaneous / Q000473:pathology*; D009447:Neuroblastoma / Q000151:congenital / Q000473:pathology*; D014133:Tracheal Diseases / Q000209:etiology / Q000473:pathology*