title: Preparation of a novel organoselenium compound and its anticancer effects on cervical cancer cell line HeLa.
abstract: This study aims at developing new organoselenium compounds with good anticancer ability and low biotoxicity. Sucrose selenious ester (sucrose-Se) was synthesized by the reaction between sucrose and selenium oxychloride. MTT assay showed that sucrose-Se effectively inhibited the proliferation of cervical cancer cell line HeLa in a dose-dependent manner without cytostatic influence on human normal liver cell line HL-7702. Morphological observation and agarose gel electrophoresis demonstrated that sucrose-Se induced apoptosis to HeLa cells. In addition, sucrose-Se was able to inhibit proliferation of bladder carcinoma cell line 5637, human malignant melanoma cell line A375, and gastric carcinoma cell line MGC-803. Median lethal dose of sucrose-Se and sodium selenite was 290.0 and 13.1 ppm, respectively, in the acute toxicity test on mice. In conclusion, sucrose-Se has potential in cancer chemoprevention due its apoptosis induction capacity and low biotoxicity.
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology (Ministry of Education), College of Chemistry, Central China Normal University, Wuhan, People's Republic of China.
authors.forename: Pei
authors.initials: P
authors.lastname: Guo
authors.forename: Peiguang
authors.initials: P
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Ma
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
authors.forename: Yu
authors.initials: Y
authors.lastname: Cao
authors.forename: Yanli
authors.initials: Y
authors.lastname: Liu
authors.forename: Hongxuan
authors.initials: H
authors.lastname: He
authors.forename: Chao
authors.initials: C
authors.lastname: Qi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D004587:Electrophoresis, Agar Gel; D005260:Female; D006367:HeLa Cells; D006801:Humans; D007928:Lethal Dose 50; D008297:Male; D008545:Melanoma / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000737:chemistry / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000473:pathology; D013395:Sucrose / Q000737:chemistry / Q000494:pharmacology; D023382:Toxicity Tests, Acute; D001749:Urinary Bladder Neoplasms / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D016566:Organoselenium Compounds; D013395:Sucrose