title: Immediate cytology improves accuracy and decreases complication rate in real-time computed tomography-guided needle lung biopsy.
abstract: Computed tomography-guided percutaneous transthoracic needle biopsy (CTNB) of the lung is a well-established diagnostic technique for the evaluation of thoracic lesions. At our institution, we have performed real-time CTNB using automated biopsy needles since 1998 and we introduced immediate cytology in 2004. We evaluate immediate cytology in CTNB to increase the diagnostic accuracy and to reduce the number of inadequate specimens. We retrospectively reviewed a consecutive series of 270 patients (group A: 98 patients before introduction, group B: 172 patients after introduction) who underwent CTNB between 2002 and 2009. We compared the diagnostic performance and the complication rates between two groups. There were no significant differences between groups A and B in patient and lesion characteristics. The rates of one time biopsy were significantly different: 56.1% (55/98) in group A and 69.2% (119/172) in group B. The rates of diagnostic accuracy in groups A and B were 79.6% (78/98) and 94.8% (163/172), respectively; the sensitivity were 74.0% (57/77) and 94.1% (127/135); the specificity were 100% (21/21) and 97.3% (36/37); the rates of major complications were 14.3% (14/98) and 2.9% (5/172). Group B had significantly higher diagnostic accuracy, sensitivity, and a lower complication rate in comparison with group A. CTNB with immediate cytology can improve diagnostic performance and decrease the complication rate. These improvements may help make CTNB less of a burden for patients.
authors.affiliation: Division of Diagnostic Pathology, Gunma Prefectural Cancer Center, 617-1 Takahayashi-nishi-cho, Ohta, Gunma, Japan; Department of Surgery, Institute of Medical Sciences, Kyorin University, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan.
authors.forename: Keisei
authors.initials: K
authors.lastname: Tachibana
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Nakazato
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tsuchida
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kazama
authors.forename: Koichi
authors.initials: K
authors.lastname: Minato
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yoshida
authors.forename: Atsushi
authors.initials: A
authors.lastname: Fujita
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Horikoshi
authors.forename: Ryota
authors.initials: R
authors.lastname: Tanaka
authors.forename: Misa
authors.initials: M
authors.lastname: Iijima
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Goya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000009:adverse effects / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods*; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011030:Pneumothorax / Q000209:etiology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*