title: Statin administration does not improve the mobilization of very small embryonic-like stem cells (VSELs) in contrast to resveratrol treatment in a murine model of acute myocardial infarction.
abstract: We have found that short-term statin treatment plus stem cell transplantation in acutely infarcted hearts improves cardiac function because statins promote the efficacy of cellular cardiomyoplasty. Autologous Sca-1(+)Lin(-)CD45(-)(CXCR(+)) very small embryonic-like stem cell (VSEL) mobilization in acute myocardial infarction (AMI) correlates with the preservation of cardiac function. Whether short-term atorvastatin (Ator) can enhance the mobilization or recruitment of VSELs in AMI is still unclear. We divided mice into 4 groups: 1) sham; 2) AMI; 3) AMI+resveratrol (RSV) as a positive control; and 4) AMI+Ator. There was an increase in the circulating VSEL/full population of leukocytes (FPL) ratio 48 hours after AMI, and AMI+RSV increased it further. Ator administration did not increase the VSEL/FPL ratio. The cardiac stromal cell-derived factor-1 (SDF-1) and SDF-1alpha levels were in agreement with the results of VSEL mobilization. One week after AMI, more Sca-1(+)CXCR(+) cells were recruited to the myocardium of AMI+RSV mice but not AMI+Ator mice. Short-term Ator administration failed to upregulate cardiac SDF-1 and could not enhance the recruitment of VSELs early after AMI.
authors.affiliation: Centre for Coronary Heart Disease, Department of Cardiology, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China. yangyjfw@yahoo.com.cn
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Yang
authors.forename: H-Y
authors.initials: HY
authors.lastname: Qian
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: L-J
authors.initials: LJ
authors.lastname: Gao
authors.forename: P
authors.initials: P
authors.lastname: Li
authors.forename: T-J
authors.initials: TJ
authors.lastname: Wang
authors.forename: S-D
authors.initials: SD
authors.lastname: Wang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D002465:Cell Movement / Q000187:drug effects*; D003131:Combined Modality Therapy; D053595:Embryonic Stem Cells / Q000187:drug effects*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009203:Myocardial Infarction / Q000473:pathology* / Q000628:therapy*; D000077185:Resveratrol; D033581:Stem Cell Transplantation / Q000379:methods*; D013267:Stilbenes / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D013267:Stilbenes; D000077185:Resveratrol