title: Design, synthesis, and biological evaluation of novel 1, 2, 4-triazole derivatives as antifungal agent.
abstract: A series of novel 1, 2, 4-triazole derivatives (9a-p) have been designed and synthesized as the potential antifungal agents. All compounds were characterized by (1)H-NMR, (13)C-NMR, and LCMS. Their antifungal activities against seven human pathogenic fungi were evaluated in vitro by measuring the minimal inhibitory concentrations. Most of the tested compounds were found to be more potent against Candida albicans than the control drug fluconazole.
authors.affiliation: Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Guohe Road 325, Shanghai 200433, China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Chai
authors.forename: Shichong
authors.initials: S
authors.lastname: Yu
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zou
authors.forename: Qiuye
authors.initials: Q
authors.lastname: Wu
authors.forename: Dazhi
authors.initials: D
authors.lastname: Zhang
authors.forename: Yuanying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yongbing
authors.initials: Y
authors.lastname: Cao
authors.forename: Qingyan
authors.initials: Q
authors.lastname: Sun
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002853:Chromatography, Liquid; D015195:Drug Design; D015725:Fluconazole / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C045575:1,2,4-triazole; D015725:Fluconazole