title: Evaluation of anti-quorum sensing activity of silver nanowires.
abstract: A menace of antimicrobial resistance with growing difficulties in eradicating clinical pathogens owing to the biofilm has prompted us to take up a facile aqueous-phase approach for the synthesis of silver nanowires (SNWs) by using ethylene glycol as a reducing agent and polyvinylpyrrolidone (PVP) as a capping agent. This synthesis is a reflux reaction seedless process. The obtained SNWs were about 200-250 nm in diameter and up to 3-4 μm in length. The SNWs were characterized by field emission scanning electron microscopy, transmission electron microscopy, UV-Vis spectroscopy, and X-Ray powder diffraction, and the chemical composition of the sample was examined by energy dispersive X-ray spectrum. The SNWs did not show an antibacterial activity against test organisms, Bacillus subtilis NCIM 2063 and Escherichia coli NCIM 2931; however, it showed a promising property of a quorum sensing-mediated inhibition of biofilm in Pseudomonas aeruginosa NCIM 2948 and violacein synthesis in Chromobacterium violaceum ATCC 12472, which is hitherto unattempted, by polyol approach.
authors.affiliation: Nanocomposite/Glass Laboratory, Centre for Materials for Electronics Technology (C-MET), Department of Information Technology, Government of India, Panchawati, Off Pashan Road, Pune 411008, India.
authors.forename: Mohini S
authors.initials: MS
authors.lastname: Wagh Nee Jagtap
authors.forename: Rajendra H
authors.initials: RH
authors.lastname: Patil
authors.forename: Deepali K
authors.initials: DK
authors.lastname: Thombre
authors.forename: Milind V
authors.initials: MV
authors.lastname: Kulkarni
authors.forename: Wasudev N
authors.initials: WN
authors.lastname: Gade
authors.forename: Bharat B
authors.initials: BB
authors.lastname: Kale
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects; D002861:Chromobacterium / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D053770:Nanowires / Q000737:chemistry / Q000633:toxicity* / Q000648:ultrastructure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D053038:Quorum Sensing / Q000187:drug effects*; D012834:Silver / Q000633:toxicity*; D013052:Spectrometry, X-Ray Emission; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
chemical_list: D012834:Silver