title: [Polymorphism of ABCB1 and ABCG2 genes encoding drug transporters and their investigation by pyrosequencing].
abstract: Published data on the effect of transporter propeins of the ABC family in the features of drug pharmacokinetics in the human organism are reviewed. Clinical significance of mononucleotide polymorphisms in ABCB1 and ABCG2 genes is analyzed. A set of genetic tests based on pyrosequencing for determing the allele state in rs1128503 (1236 T > C), rs2032582 (2677T > A/G), rs1045642 (3435 T > A/C), rs2231142 (421C > A), and rs72552713 (376 C > T) polymorphisms in ABCB1 and ABCG2 genes has been developed and verified. These tests can be used in both research work and clinical practice for calculating recommended doses of various drugs, predicting their therapeutic efficacy, and determining groups of risk with respect to the developent of undesired secondary reactions.
authors.forename: O P
authors.initials: OP
authors.lastname: Dribnokhodova
authors.forename: K O
authors.initials: KO
authors.lastname: Mironov
authors.forename: E A
authors.initials: EA
authors.lastname: Dunaeva
authors.forename: G A
authors.initials: GA
authors.lastname: Shipulin
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics* / Q000378:metabolism; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D010597:Pharmacogenetics / Q000379:methods*; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA / Q000379:methods*
chemical_list: C513055:ABCB1 protein, human; C116614:ABCG2 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D009363:Neoplasm Proteins