title: α-granules: a story in the making.
abstract: α-granules are by far the most abundant platelet granules. Yet little is known about how they are formed. In this issue of Blood, Urban et al now characterize platelets from patients with an inheritable α-granule defect, demonstrating a role for VPS16B in α-granule biogenesis and taking us one step closer to understanding how these elusive organelles are formed.
authors.affiliation: Beth Israel Deaconess Medical Center.
authors.forename: Robert
authors.initials: R
authors.lastname: Flaumenhaft
mesh_terms: D001792:Blood Platelets / Q000473:pathology*; D002352:Carrier Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008533:Megakaryocytes / Q000473:pathology*; D022142:Secretory Vesicles / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; C539711:VIPAS39 protein, human; C411584:VPS33B protein, human; D033921:Vesicular Transport Proteins