title: Preventive effects of (-) epicatechin on altered adenosine triphosphatases and minerals in isoproterenol-induced myocardial infarcted rats.
abstract: The present study was aimed to evaluate the preventive effects of (-) epicatechin on alterations in the activities/levels of adenosine triphosphatases and minerals in isoproterenol-induced myocardial infarcted rats. Male albino Wistar rats were pretreated with (-) epicatechin (20 mg/kg body weight) daily for a period of 21 days. After the pretreatment period, rats were induced myocardial infarction by isoproterenol (100 mg/kg body weight) on 22nd and 23rd day. The activity of sodium/potassium-dependent adenosine triphosphatase was decreased, and the activities of calcium- and magnesium-dependent adenosine triphosphatases were increased in the heart of isoproterenol-induced myocardial infarcted rats. In addition, the concentrations of potassium were decreased and the concentrations of sodium and calcium were increased in the heart of isoproterenol-induced rats. Elevated plasma lipid peroxidation was noted in isoproterenol-induced rats. Prior treatment with (-) epicatechin significantly prevented the alterations in the activities and concentrations of adenosine triphosphatases, minerals, and plasma lipid peroxidation. The in vitro study confirmed the reducing property of (-) epicatechin. The observed effects in this study are attributed to the membrane-stabilizing and antioxidant properties of (-) epicatechin. The findings of this study will be beneficial to prevent the occurrence of myocardial infarction.
authors.affiliation: Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, 608 002, India. ps_mainzenprince@yahoo.co.in
authors.forename: P
authors.initials: P
authors.lastname: Stanely Mainzen Prince
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002392:Catechin / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology*; D015227:Lipid Peroxidation; D008297:Male; D008903:Minerals / Q000378:metabolism*; D009203:Myocardial Infarction / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008903:Minerals; D002392:Catechin; D000251:Adenosine Triphosphatases; D007545:Isoproterenol