title: Phenolic compounds from Caesalpinia sappan heartwood and their anti-inflammatory activity.
abstract: Four new phenolic compounds, caesalpiniaphenols A-D (1-4), together with eight known compounds were isolated from Caesalpinia sappan heartwood. The chemical structures were established mainly by NMR, MS, ECD, and Mosher's method. Compounds 4, 5, and 7 showed weak inhibitory activity against the LPS-induced NO production in macrophage RAW264.7 cells with IC(50) values of 12.2, 3.5, and 5.7 μM, respectively.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk 712-702, Korea.
authors.forename: To Dao
authors.initials: TD
authors.lastname: Cuong
authors.forename: Tran Manh
authors.initials: TM
authors.lastname: Hung
authors.forename: Jin Cheol
authors.initials: JC
authors.lastname: Kim
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
authors.forename: Jae Sue
authors.initials: JS
authors.lastname: Choi
authors.forename: Jeong Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029911:Caesalpinia / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000032:analysis / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D056910:Republic of Korea; D014934:Wood / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D010636:Phenols; C578417:caesalpiniaphenol D; D009569:Nitric Oxide