title: Rosacea: update on management and emerging therapies.
abstract: Rosacea is a common chronic skin disorder that has significant impact on the self-esteem and quality of life of affected individuals. Currently understood as an inflammatory condition that occurs in the context of an altered innate immune response, the available topical and systemic therapies function as immunomodulators to restore cutaneous homeostasis. The goals of therapy include reduction of papules, pustules, erythema and physical discomfort with improvement in quality of life. Standard topical treatments include metronidazole and azelaic acid, although many other agents and regimens have been presented. Subantimicrobial/antiinflammatory dose oral doxycycline was US FDA approved in 2006 for the management of rosacea, but Health Canada clearance was only recently granted for this indication. Furthermore, renewed research interest has led to the development of other emerging therapies including topical ivermectin, brimonidine and oxymetazoline that hold promise for patients suffering from this condition.
authors.affiliation: McMaster University, Hamilton, ON, Canada.
authors.forename: Robyn S
authors.initials: RS
authors.lastname: Fallen
authors.forename: Melinda
authors.initials: M
authors.lastname: Gooderham
mesh_terms: D000279:Administration, Cutaneous; D018663:Adrenergic Agents / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000977:Antiparasitic Agents / Q000008:administration & dosage*; D000068438:Brimonidine Tartrate; D003879:Dermatologic Agents / Q000008:administration & dosage*; D003998:Dicarboxylic Acids / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D010109:Oxymetazoline / Q000008:administration & dosage; D011788:Quality of Life; D011810:Quinoxalines / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic; D012393:Rosacea / Q000188:drug therapy* / Q000503:physiopathology; D013409:Sulfacetamide / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D018663:Adrenergic Agents; D000890:Anti-Infective Agents; D000977:Antiparasitic Agents; D003879:Dermatologic Agents; D003998:Dicarboxylic Acids; D011810:Quinoxalines; D008795:Metronidazole; D013409:Sulfacetamide; D000068438:Brimonidine Tartrate; D007559:Ivermectin; D010109:Oxymetazoline; C010038:azelaic acid; D004318:Doxycycline