title: Neonectrolide A, a new oxaphenalenone spiroketal from the fungus Neonectria sp.
abstract: Neonectrolide A (1), an oxaphenalenone spiroketal with the previously undescribed (5,8'-dimethyl-5'-oxo-3a',4,5,5'-tetrahydro-3H,3'H-spiro[furan-2,2'-isochromeno[3,4,5-def]chromene]-3'-yl)but-3-enoic acid skeleton, was isolated from cultures of the fungus Neonectria sp. Its absolute configuration was assigned by electronic circular dichroism (ECD) calculations. The skeleton of an oxaphenalenone fused with a 1,6-dioxaspiro[4.5]decane moiety in 1 could be derived from the coisolated putative precursors, corymbiferan lactone E (2) and 3-dehydroxy-4-O-acetylcephalosporolide C (3).
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Jinwei
authors.initials: J
authors.lastname: Ren
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Xingzhong
authors.initials: X
authors.lastname: Liu
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*; D006999:Hypocreales / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D005663:Furans; D013141:Spiro Compounds; C578822:neonectrolide A; C520774:spiroketal