title: [The endocannabinoid system and its role in regulation of metabolism in peripheral tissues].
abstract: The endocannabinoid system (ECS) comprises cannabinoid receptors (CB1R and CB2R), endogenous lipid ligands (endocannabinoids) and enzymes that synthesize and degrade these compounds. ECS is involved in the regulation of lipogenesis and fatty acids utilization in liver, skeletal muscle and adipose tissue. Activation of CB1 receptor leads to: (i) increase in the activity of transcription factors which regulate gene expression involved in lipid synthesis (SREBP-1c, PPARgamma), (ii) inhibition of AMP-activated protein kinase and (iii) decrease in fatty acid oxidation. Furthermore, increased level of endocannabinoids is associated with reduced insulin sensitivity in skeletal muscle. ECS is also involved in regulation of adipocyte differentiation. This review summarizes the current knowledge on the regulatory function of endocannabinoids and addresses the role of ECS in the pathogenesis of metabolic disorders.
authors.affiliation: Pracownia Sygnałów Komórkowych i Zaburzeń Metabolicznych, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego PAN, Warszawa.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Rumińska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Dobrzyń
mesh_terms: D017667:Adipocytes / Q000166:cytology; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D063388:Endocannabinoids / Q000378:metabolism*; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D050155:Lipogenesis / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism; D043882:Receptors, Cannabinoid / Q000378:metabolism*
chemical_list: D063388:Endocannabinoids; D005227:Fatty Acids; D043882:Receptors, Cannabinoid