title: [Antimicrobial susceptibility of Helicobacter pylori with chronic gastritis].
abstract: BACKGROUND
  Infection by Helicobacter pylori is prevalent in approximately half the world´s population.However, the susceptibility of H. pylori to antimicrobial agents must be evaluated by in vitro methods in order to determine the susceptibility levels and to guide treatment regimes.
  
  
  OBJECTIVE
  The prevalence of infection and antibiotic susceptibility was evaluated in gastric biopsies containing H. pylori.
  
  
  METHODS
  The prevalence of infection and antibiotic susceptibility was investigated in 203 patients with chronic gastritis from Tumaco, Colombia. Diagnosis was confirmed by histopathological evidence (Dixon scale) and microbiological (culture on blood agar supplemented with antibiotics).The antibiotic resistance of H. pylori was measured by its response toantimicrobial amoxicillin and clarithromycin using the agar dilution method.
  
  
  RESULTS
  The prevalence of infection for H. pylori with histopathological and microbiological tests was88.7% and 84.7% respectively. The prevalence of resistance of H. pylori to antimicrobial amoxicillin was 20.5%, to clarithromycin 19.8%, and to both antibiotics concurrently, 10.9%.
  
  
  CONCLUSIONS
  A high incidence of clarithromycin-resistant and amoxicillin-resistant H. pylori was discovered in patients from Tumaco with chronic gastritis. Dual drug-resistant strains of H. pylori to clarithromycin and amoxicillin were also present.
authors.affiliation: Departamento de Patología, Universidad del Valle, Cali, Colombia. mercedeslab1@gmail.com
authors.forename: Mercedes
authors.initials: M
authors.lastname: Figueroa
authors.forename: Armando
authors.initials: A
authors.lastname: Cortés
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Pazos
authors.forename: Luis Eduardo
authors.initials: LE
authors.lastname: Bravo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001706:Biopsy; D002908:Chronic Disease; D017291:Clarithromycin / Q000494:pharmacology*; D003105:Colombia / Q000453:epidemiology; D003441:Crowding; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D005756:Gastritis / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012907:Smoking / Q000453:epidemiology; D012959:Socioeconomic Factors; D017673:Sodium Chloride, Dietary; D013274:Stomach Neoplasms / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D017673:Sodium Chloride, Dietary; D000658:Amoxicillin; D017291:Clarithromycin