title: [Chemoradiotherapy for advanced gastric cancer].
abstract: In the US and Europe, chemoradiotherapy has become a standard treatment not only for head and neck cancer, esophageal cancer, pancreatic cancer, and rectal cancer, but also for gastric cancer. In particular, chemoradiotherapy has been established as an adjuvant therapy. In Japan, it has not been established as a standard treatment. Its indications are limited, and it is often performed as palliative care. Disadvantages of radiation therapy for gastric cancer include the difficulty of establishing the area to irradiate due to peristaltic movement, risk of perforation and ulceration from high-dose radiation, and ineffectiveness against adenocarcinoma with low radiosensitivity. In recent years, technological advancement of radiation therapy has enabled pinpoint accuracy in the treatment of primary gastric lesions and regional lymph nodes. There has been much anticipation that chemoradiotherapy will become a part of multidisciplinary treatment for advanced cancer. This report describes the current state of chemoradiotherapy for gastric cancer in Japan and overseas, and outlines our approach to locally advanced gastric cancer.
authors.affiliation: Keio Cancer Center, Keio University, Japan.
authors.forename: Tsunehiro
authors.initials: T
authors.lastname: Takahashi
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Saikawa
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Fukuda
authors.forename: Norihito
authors.initials: N
authors.lastname: Wada
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kawakubo
authors.forename: Hiroya
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Junichi
authors.initials: J
authors.lastname: Fukada
authors.forename: Osamu
authors.initials: O
authors.lastname: Kawaguchi
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Takaishi
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Shigematsu
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kitagawa
mesh_terms: D059248:Chemoradiotherapy; D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology / Q000628:therapy*