title: The contribution of the sodium-calcium exchanger (NCX) and plasma membrane Ca(2+) ATPase (PMCA) to cerebellar synapse function.
abstract: The cerebellum, a part of the brain critically involved in motor learning and sensory adaptation, expresses high levels of the sodium-calcium exchanger (NCX) and the plasma membrane calcium ATPase (PMCA). Both these transporters control calcium dynamics at a variety of synapses, and here, we draw upon the available literature to discuss how NCX and PMCA work together to shape pre-synaptic calcium dynamics at cerebellar synapses.
authors.affiliation: Department of Physiology, University of Otago, Dunedin, New Zealand. ruth.empson@otago.ac.nz
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Roome
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Empson
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism; D002531:Cerebellum / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007858:Learning / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000235:genetics / Q000378:metabolism*; D019831:Sodium-Calcium Exchanger / Q000235:genetics / Q000378:metabolism*; D013569:Synapses / Q000235:genetics / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D019831:Sodium-Calcium Exchanger; D053499:Plasma Membrane Calcium-Transporting ATPases; D002118:Calcium