title: Metabolic syndrome and stroke recurrence in Chinese ischemic stroke patients--the ACROSS-China study.
abstract: OBJECTIVE
  Metabolic syndrome has emerged as a novel risk factor in cardiovascular disease due to its potential for predicting stroke in population-based studies. We investigated the relationship of metabolic syndrome with stroke recurrence.
  
  
  METHODS
  This was a retrospective analysis of Chinese patients enrolled in the prospective Abnormal gluCose Regulation in patients with acute strOke acroSS China (ACROSS-China) study after their first ischemic stroke. Metabolic syndrome was defined using the International Diabetes Federation (IDF) criteria. Vascular risk factors were assessed. Outcome was defined as recurrence of stroke within one year after the index ischemic stroke. Cox proportional hazards regression was performed to identify potential predictors of stroke recurrence.
  
  
  RESULTS
  The prevalence of metabolic syndrome among 2639 ischemic stroke patients was 51.35%. During the one-year follow-up, 195 strokes (7.4%) recurred. The multivariate hazard ratio (95% CI) of stroke recurrence was 1.94 (1.39-2.73) for metabolic syndrome. After adjustment for components, metabolic syndrome lost its association with stroke recurrence; in this model, high fasting plasma glucose (IDF definition) was a predictor for stroke recurrence.
  
  
  CONCLUSIONS
  Metabolic syndrome may not be predictive for stroke recurrence beyond its component individual factors for Chinese ischemic stroke patients.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Donghua
authors.initials: D
authors.lastname: Mi
authors.forename: Qian
authors.initials: Q
authors.lastname: Jia
authors.forename: Huaguang
authors.initials: H
authors.lastname: Zheng
authors.forename: Kolin
authors.initials: K
authors.lastname: Hoff
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.forename: Chunxue
authors.initials: C
authors.lastname: Wang
authors.forename: Gaifen
authors.initials: G
authors.lastname: Liu
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.forename: Xianwei
authors.initials: X
authors.lastname: Wang
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People; D002545:Brain Ischemia / Q000150:complications* / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged; D008954:Models, Biological; D016016:Proportional Hazards Models; D012008:Recurrence; D020521:Stroke / Q000150:complications* / Q000453:epidemiology; D016896:Treatment Outcome