title: Possible link of pioglitazone with bladder cancer in Japanese patients with type 2 diabetes.
abstract: We retrospectively examined the frequency of bladder cancer in Japanese patients with type 2 diabetes in relation to use of pioglitazone. Among a total of 663 patients identified to be taking pioglitazone, 9 had bladder cancer (1.36%). Overall the hazard ratio of 1.75 [95% CI: 0.89-3.45] for pioglitazone for bladder cancer was not significant. However the prevalence of bladder cancer was 2.10% in patients taking pioglitazone for less than 24 months which was significant increased (HR 2.73 [95% CI: 1.11-6.72]).
authors.affiliation: Center for Diabetes and Endocrinology, Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital, Osaka, Japan.
authors.forename: Kanta
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hamamoto
authors.forename: Sachiko
authors.initials: S
authors.lastname: Honjo
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Kanako
authors.initials: K
authors.lastname: Mori
authors.forename: Hisato
authors.initials: H
authors.lastname: Tatsuoka
authors.forename: Atsuko
authors.initials: A
authors.lastname: Matsuoka
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Wada
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeda
authors.forename: Jun
authors.initials: J
authors.lastname: Fujikawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koshiyama
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D000077205:Pioglitazone; D012189:Retrospective Studies; D045162:Thiazolidinediones / Q000009:adverse effects* / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
chemical_list: D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077205:Pioglitazone