title: In silico search of DNA drugs targeting oncogenes.
abstract: Triplex forming oligonucleotides (TFOs) represent a class of drug candidates for antigene therapy. Based on strict criteria, we investigated the potential of 25 known oncogenes to be regulated by TFOs in the mRNA synthesis level and we report specific target sequences found in seven of these genes.
authors.affiliation: Department of Biology, University of Crete and Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), 100 Nikolaou Plastira str, Heraklion 70013, Greece. gpapadak@imbb.forth.gr
authors.forename: George
authors.initials: G
authors.lastname: Papadakis
authors.forename: Electra
authors.initials: E
authors.lastname: Gizeli
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001483:Base Sequence; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D018390:Gene Targeting / Q000379:methods*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D058990:Molecular Targeted Therapy; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry; D009857:Oncogenes / Q000187:drug effects*; D012333:RNA, Messenger / Q000235:genetics; D017422:Sequence Analysis, DNA / Q000379:methods*; D014158:Transcription, Genetic
chemical_list: D000970:Antineoplastic Agents; D009841:Oligonucleotides; D012333:RNA, Messenger; D004247:DNA