title: A new platinum-bromine cyclohexanediamine complex from the family of cancer cytostatics.
abstract: Another new substance from the family of Pt-based coordination complexes with potential use in cancer chemotherapy has been synthesized, crystallized and structurally characterized. In this compound {systematic name cis-dibromido[(1R,2R)-cyclohexane-1,2-diamine-κ(2)N,N']platinum(II)}, cis-[PtBr(2)(C(6)H(14)N(2))], there are two molecules with very similar conformations in the asymmetric unit. The component species interact by way of N-H...Br and C-H...Br hydrogen bonds to give two-dimensional networks which lie parallel to the (100) plane.
authors.affiliation: Central Laboratories, Institute of Chemical Technology, Prague, Czech Republic. richard.pazout@vscht.cz
authors.forename: Richard
authors.initials: R
authors.lastname: Pazout
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Maixner
authors.forename: Jitka
authors.initials: J
authors.lastname: Holakovská
authors.forename: Michal
authors.initials: M
authors.lastname: Dušek
authors.forename: Petr
authors.initials: P
authors.lastname: Kačer
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003510:Cyclohexanes / Q000737:chemistry*; D054697:Cytostatic Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D003959:Diamines / Q000737:chemistry*; D051379:Mice; D008968:Molecular Conformation; D009369:Neoplasms / Q000737:chemistry* / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D003510:Cyclohexanes; D054697:Cytostatic Agents; D003959:Diamines; D009944:Organoplatinum Compounds; C579081:cis-dibromido((1R,2R)-cyclohexane-1,2-diamine-kappa(2)N,N')platinum(II); C506365:Cyclohexane