title: [The latest progress in the pathogenesis and diagnosis of Graves' disease].
abstract: Graves' disease is a unique autoimmune disease with cell proliferation and excess function, caused by anti-thyrotropin receptor antibody (TRAb), and apart from antibody-mediated organ destruction seen in other autoimmune diseases. In this article, we discuss the latest progress in the research field of TRAb. The biological natures of various TRAbs are also summarized. Additionally, we introduce the development of a full-automated and rapid measurement system for TRAb. Measurement of the titer of TRAb within one hour in office setting enables clinicians to make more concrete diagnosis of Graves' disease at the first visit of patients.
authors.affiliation: Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kimura
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Okamoto
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D003937:Diagnosis, Differential; D006111:Graves Disease / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000276:immunology; D011989:Receptors, Thyrotropin / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D011989:Receptors, Thyrotropin