title: Palladium-promoted [2 + 2 + 2] cocyclization of arynes and unsymmetrical conjugated dienes: synthesis of justicidin B and retrojusticidin B.
abstract: A facile synthesis of natural and unnatural arylnaphthalenes has been demonstrated via the unprecedented palladium-promoted [2 + 2 + 2] cocyclization of arynes and unsymmetrical conjugated dienes using the N-heterocyclic carbene as a ligand. The unsymmetrical dienes used herein are actually α-coupled acrylate-cinnamate combinations bearing two β-positive carbons and follow the key [2 + 2 + 2] cocyclization pathway.
authors.affiliation: Division of Organic Chemistry, National Chemical Laboratory (CSIR), Pune 411 008, India.
authors.forename: Ramesh M
authors.initials: RM
authors.lastname: Patel
authors.forename: Narshinha P
authors.initials: NP
authors.lastname: Argade
mesh_terms: D002384:Catalysis; D003500:Cyclization; D004148:Dioxolanes / Q000138:chemical synthesis* / Q000737:chemistry; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D004148:Dioxolanes; D017705:Lignans; D009281:Naphthalenes; C049719:justicidins; C496008:retrojusticidin B; D010165:Palladium