title: Microparticles: a component of various diseases.
abstract: Microparticles (MPs) are phenotypically and functionally heterogeneous population of microvesicles. Although MP formation represents a physiological phenomenon. A multitude of pathologies, including inflammatory and autoimmune diseases, atherosclerosis, and malignancies, are associated with a considerable increase in circulating MPs. Elevated levels of platelet‑, endothelial cell‑, and monocyte‑derived MPs have been documented in a number of clinical conditions in which vascular dysfunction and inflammation are important pathophysiological mechanisms (e.g., coronary artery disease or thrombotic microangiopathies). Knowledge of the functional properties of MPs will contribute to a better understanding of the pathological mechanisms of communication between cells and of the causes of various diseases.
authors.affiliation: Institute of Normal and Pathological Physiology, Comenius University in Bratislava, Bratislava, Slovakia. miroslav.budaj@fmed.uniba.sk
authors.forename: Miroslav
authors.initials: M
authors.lastname: Budaj
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Poljak
authors.forename: Ivan
authors.initials: I
authors.lastname: Ďuriš
authors.forename: Martin
authors.initials: M
authors.lastname: Kaško
authors.forename: Richard
authors.initials: R
authors.lastname: Imrich
authors.forename: Martin
authors.initials: M
authors.lastname: Kopáni
authors.forename: Lenka
authors.initials: L
authors.lastname: Maruščáková
authors.forename: Ivan
authors.initials: I
authors.lastname: Hulín
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology*; D055252:Cell-Derived Microparticles / Q000378:metabolism / Q000473:pathology*; D042783:Endothelial Cells / Q000378:metabolism / Q000473:pathology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*