title: Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats.
abstract: A role of cholinergic nervous system in the behavioral impairments induced by repeated ECS is not understood. The α4β2 nicotinic acetylcholine receptor (nAChR) agonist ABT-418, but not the α7 nAChR agonist, significantly ameliorated the impairment of spontaneous alternation behavior in the Y-maze test. And, repeated ECS caused a reduction of α4 nAChR-positive cells in the prefrontal cortex and hippocampus. Thus, the α4β2 nAChR is related to ECS-induced deficits in rats.
authors.affiliation: Division of Pharmacy, Ehime University Hospital, Shitsukawa, Toon, Ehime 791-0295, Japan. noridah@m.ehime-u.ac.jp
authors.forename: Noriaki
authors.initials: N
authors.lastname: Hidaka
authors.forename: Katsuya
authors.initials: K
authors.lastname: Suemaru
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kato
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Araki
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D004597:Electroshock / Q000379:methods; D007555:Isoxazoles / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology; D011759:Pyrrolidines / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D011978:Receptors, Nicotinic / Q000235:genetics / Q000502:physiology*; D012008:Recurrence; D012640:Seizures / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*
chemical_list: D007555:Isoxazoles; D011759:Pyrrolidines; D011978:Receptors, Nicotinic; C403531:nicotinic receptor alpha4beta2; C088383:3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole