title: Effects of contrast agent and outer volume saturation bands on water suppression and shimming of hepatic single-volume proton MR spectroscopy at 3.0T.
abstract: OBJECTIVE
  To determine whether administration of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) and whether placement of the outer volume saturation bands significantly affect shimming and water suppression on hepatic MR spectroscopic prescanning.
  
  
  METHODS
  Region of interest (ROI) of 2 cm × 2 cm × 2 cm was carefully positioned in the region of the middle portion of the right hepatic lobe. 32 patients were examined before and after administration of Gd-DTPA with and without outer-volume saturation bands. Linewidths (Full-Width Half-Maximum (FWHM)) and water suppression were obtained. A paired t-test for comparison of means was used.
  
  
  RESULTS
  (1) The group with the outer volume saturation bands demonstrated slightly better water suppression effect than the group without outer volume saturation bands before administration. (2) The group with the outer volume saturation bands demonstrated better water suppression effect than the group without outer volume saturation bands after administration. (3) Both shimming and water suppression effects were decreased on enhanced MR spectroscopic prescanning (all P < 0.05).
  
  
  CONCLUSIONS
  Placement of the outer volume saturation bands is helpful to improve water suppression both before and after contrast agent administration. Gd-DTPA exerts a slightly adverse effect (a statistically significant but clinically unimportant) on magnetic resonance spectroscopic prescanning at 3T.
authors.affiliation: Department of Radiology, Guangdong Provincial Traditional Chinese Medicine Hospital and Postdoctoral Mobile Research Station of Guangzhou University of Traditional Chinese Medicine, 111 Da De Lu, Guangdong, Guangzhou 510120, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Xian
authors.initials: X
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000494:pharmacology; D005260:Female; D019786:Gadolinium DTPA / Q000494:pharmacology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008099:Liver / Q000737:chemistry* / Q000187:drug effects* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D057054:Molecular Imaging / Q000379:methods; D011522:Protons; D014867:Water / Q000032:analysis* / Q000737:chemistry; D055815:Young Adult
chemical_list: D003287:Contrast Media; D011522:Protons; D014867:Water; D019786:Gadolinium DTPA