title: Determination of the ideal preparation for colonoscopy in a rat model.
abstract: BACKGROUND
  Quality bowel preparation is essential to examine the entire colon adequately. No trials comparing different purgative regimens are available in animal models. The aim was to compare 5 methods for bowel cleansing to develop a rat model to study therapeutic colonoscopy.
  
  
  METHODS
  Twenty-five rats were assigned to one of 5 regimens: (1) high-volume polyethylene glycol electrolyte solution (HV-PEG-ES, 40 mL); (2) low-volume PEG-ES (LV-PEG-ES, 20 mL); (3) high-volume PEG-ES+ascorbic acid (HV-PEG-ES+AA, 20 mL); (4) LV-PEG-ES+AA, 10 mL; (5) rectal enema with saline solution (RE-SS). Bowel preparation quality was rated by total colonoscopy.
  
  
  RESULTS
  RE-SS is the best regime for left colon cleansing, whereas HV-PEG-ES and HV-PEG-ES+AA solutions resulted in significantly better cleansing in the whole colon. HV-PEG-ES+AA regimen needed less volume, and administration was easier.
  
  
  CONCLUSIONS
  A total of 20 mL of PEG-ES+AA before colonoscopy is the best regimen to explore the whole colon, whereas to explore the left colon RE-SS is adequate.
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas-CIBEREHD, Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
authors.forename: Ramon
authors.initials: R
authors.lastname: Bartolí
authors.forename: Jaume
authors.initials: J
authors.lastname: Boix
authors.forename: Gemma
authors.initials: G
authors.lastname: Odena
authors.forename: Vicente
authors.initials: V
authors.lastname: de Vega Moreno
authors.forename: Vicente
authors.initials: V
authors.lastname: Lorenzo-Zúñiga
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D002400:Cathartics / Q000008:administration & dosage / Q000494:pharmacology*; D003113:Colonoscopy / Q000379:methods*; D004334:Drug Administration Schedule; D004573:Electrolytes / Q000008:administration & dosage / Q000494:pharmacology*; D004733:Enema / Q000379:methods; D007441:Intubation, Gastrointestinal; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002400:Cathartics; D004573:Electrolytes; D011092:Polyethylene Glycols; D001205:Ascorbic Acid