title: [Risk factors for coronary artery lesions in children with Kawasaki disease].
abstract: OBJECTIVE
  To study risk factors for the development of coronary artery lesions (CAL) in children with Kawasaki disease (KD).
  
  
  METHODS
  The clinical data of 527 children with KD between January 2006 and January 2009 were retrospectively reviewed. A total of 15 potential factors associated with occurrence of CAL were evaluated by univariate analysis and multivariate logistic regression analysis.
  
  
  RESULTS
  The univariate analysis showed that age, gender, KD type, starting time of intravenous immunoglobulin (IVIG) treatment, response to IVIG treatment, additional treatment with corticosteroids, duration of fever and serum C-reactive protein level were significantly different between patients with and without CAL (P<0.05). Multivariate logistic regression analysis showed that an age of less than 1 year (OR=2.076, P<0.05) or greater than 8 years (OR=1.890, P<0.05), male sex (OR=1.972, P<0.05), incomplete KD (OR=1.426, P<0.05), delayed starting time of IVIG treatment (10 days after onset) (OR=3.251, P<0.05), no response to IVIG (OR=2.301, P<0.05) and fever duration of more than 10 days (OR=1.694, P<0.05) were independent risk factors for the development of CAL, whereas early starting time of IVIG treatment (before 5 days after onset) was a protective factor (OR=0.248, P<0.05).
  
  
  CONCLUSIONS
  The occurrence of CAL is associated with many factors in children with KD. Age of less than 1 year or greater than 8 years, male sex, incomplete KD, delayed IVIG treatment after onset, no response to IVIG treatment and prolonged fever duration have been identified as risk factors for the development of CAL.
authors.affiliation: Department of Pediatric Cardiology, Chengdu Women and Children's Central Hospital, Chengdu, China. 1983777939@qq.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Xian-Min
authors.initials: XM
authors.lastname: Wang
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Liu
authors.forename: Kun
authors.initials: K
authors.lastname: Shi
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Yang
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D016015:Logistic Models; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000188:drug therapy; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous