title: Cytotoxic cyclic depsipeptides from the Australian marine sponge Neamphius huxleyi.
abstract: Three new cyclic depsipeptides, neamphamides B (2), C (3), and D (4), were isolated from the Australian sponge Neamphius huxleyi. The planar structural characterization of these molecules was elucidated using 2D NMR experiments and ESI-FTICR-MS(n). Their configurations were determined by Marfey's method and J-based NMR analysis. These new metabolites inhibited the growth of human cell lines (A549, HeLa, LNCaP, PC3, and NFF) with IC(50) values ranging from 88 to 370 nM. However, neamphamide D causes A549 cell proliferation at subcytotoxic doses and should be treated cautiously as a cytotoxic compound.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
authors.forename: Trong D
authors.initials: TD
authors.lastname: Tran
authors.forename: Ngoc B
authors.initials: NB
authors.lastname: Pham
authors.forename: Gregory
authors.initials: G
authors.lastname: Fechner
authors.forename: Dusan
authors.initials: D
authors.lastname: Zencak
authors.forename: Hoan T
authors.initials: HT
authors.lastname: Vu
authors.forename: John N A
authors.initials: JN
authors.lastname: Hooper
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001315:Australia; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides