title: Influences of stearidonic acid-enriched soybean oil on the blood and organ biochemical parameters in rats.
abstract: In this study, we administered various diets of stearidonic acid (SDA, 18:4n-3) soybean oil to rats and examined the subsequent blood and organ biochemical parameters. Male Wistar rats (seven rats/group, six groups total) were fed diets supplemented with a test oil for 4 weeks. Diets containing test oils were: FFC diet (fish-oil-free control diet), C diet (control group, assuming a Japanese diet), SDA25 diet (25% 18:4n-3 soybean oil in the C diet), SDA50 (50% 18:4n-3 soybean oil in the C diet), ALA diet (34% flaxseed oil in the C diet), and EPA+DHA diet (34% fish oil in the C diet). The intake of 18:4n-3 showed increased relative efficiency of 20:5n-3 accretions in serum and liver triacylglycerol and significantly decreased the serum triacylglycerol level in rats. The results suggested that the consumption of 18:4n-3 soybean oil may modify the lipid and fatty acid profiles of body fats, even when EPA and DHA derived from fish is consumed.
authors.affiliation: Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama 350-0288, Japan. kawabata@eiyo.ac.jp
authors.forename: Terue
authors.initials: T
authors.lastname: Kawabata
authors.forename: Kazumi
authors.initials: K
authors.lastname: Shimoda
authors.forename: Sayaka
authors.initials: S
authors.lastname: Horiguchi
authors.forename: Marina
authors.initials: M
authors.lastname: Domon
authors.forename: Chie
authors.initials: C
authors.lastname: Hagiwara
authors.forename: Miho
authors.initials: M
authors.lastname: Takiyama
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kagawa
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D015118:Eicosapentaenoic Acid / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013024:Soybean Oil / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D014280:Triglycerides; D013024:Soybean Oil; D015118:Eicosapentaenoic Acid; C062895:stearidonic acid