title: Discovering associations in biomedical datasets by link-based associative classifier (LAC).
abstract: Associative classification mining (ACM) can be used to provide predictive models with high accuracy as well as interpretability. However, traditional ACM ignores the difference of significances among the features used for mining. Although weighted associative classification mining (WACM) addresses this issue by assigning different weights to features, most implementations can only be utilized when pre-assigned weights are available. In this paper, we propose a link-based approach to automatically derive weight information from a dataset using link-based models which treat the dataset as a bipartite model. By combining this link-based feature weighting method with a traditional ACM method-classification based on associations (CBA), a Link-based Associative Classifier (LAC) is developed. We then demonstrate the application of LAC to biomedical datasets for association discovery between chemical compounds and bioactivities or diseases. The results indicate that the novel link-based weighting method is comparable to support vector machine (SVM) and RELIEF method, and is capable of capturing significant features. Additionally, LAC is shown to produce models with high accuracies and discover interesting associations which may otherwise remain unrevealed by traditional ACM.
authors.affiliation: School of Informatics and Computing, Indiana University, Bloomington, Indiana, United States of America.
authors.forename: Pulan
authors.initials: P
authors.lastname: Yu
authors.forename: David J
authors.initials: DJ
authors.lastname: Wild
mesh_terms: D000465:Algorithms; D045744:Cell Line, Tumor; D019992:Databases as Topic; D006801:Humans; D008954:Models, Biological; D009152:Mutagenicity Tests