title: [Histostructural changes of rat cerebral cortex during hemorrhagic stroke modeling].
abstract: Pathological changes during modeling of primary and secondary acute hemorrhagic stroke were studied in rats. We revealed differences in the activity of pharmacological action of medications under condition of acute stroke. The action of medications increased viability of neurons in both hemispheres of rat cerebrum at a right-side primary and secondary hemorrhagic stroke. Following secondary stroke, the amount of degenerative neurons amounted 25.5 +/- 0.8 cells/mm2, following the action ofcerebrolysin this value was 17.6 +/- 1.7 cells/ mm2 and after the action of cortexine and cerebral this value amounted 18.0 +/- 0.9 cells/mm2 and 10.7 +/- 0.4 cells/ mm2, respectively. In control animals the number of degenerative neurons did not exceed 2% and averaged 1.5 +/- 0.1 cells/mm2. Analysis of the morphological and statistical data showed that the most effective remedies under the primary and secondary hemorrhagic insult are cortexine and cerebral. Cerebral was found to be more effective.
authors.forename: S I
authors.initials: SI
authors.lastname: Savos'ko
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Chaĭkovs'kyĭ
authors.forename: N Kh
authors.initials: NKh
authors.lastname: Pogoriela
authors.forename: O M
authors.initials: OM
authors.lastname: Makarenko
mesh_terms: D000208:Acute Disease; D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D054022:Cerebrum / Q000187:drug effects / Q000473:pathology*; D004195:Disease Models, Animal; D004801:Eosine Yellowish-(YS); D005260:Female; D006416:Hematoxylin; D036341:Intercellular Signaling Peptides and Proteins; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D051381:Rats; D020521:Stroke / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000596:Amino Acids; D036341:Intercellular Signaling Peptides and Proteins; D018696:Neuroprotective Agents; D010455:Peptides; C006952:cerebrolysin; C056590:cortexin; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin