title: Why are the neurodegenerative disease-related pathways overrepresented in primary HIV-infected peripheral blood mononuclear cells: a genome-wide perspective.
abstract: We demonstrate for the first time that the genome-wide profiling of HIV-infected peripheral blood mononuclear cells (PBMCs) from HIV-patients free of neurologic disease show overrepresentation of neurodegenerative pathways (Alzheimer's, Parkinson's, ALS, Huntington's and Prion Disease, etc.) in genome-wide microarray analysis, which suggests that this genome-wide representation of neurodegenerative diseases-related pathways in PBMCs could possibly be a subcellular manifestation of neurologic interference by HIV. Further, the cell-tagging analysis attested this belief showing the large majority of genes tagged with cells of monocyte and macrophage lineage, which are implicated in neuronal dysfunction in both viral and non-viral neurodegenerative diseases. Together, these findings suggest that the genomic interference of HIV with neurodegenerative pathways is not by chance, but may be an early sign of HIV-mediated sub-genomic and sub-cellular manifestation of neurologic disease. Moreover, these findings signify the utility of PBMC and genome-wide mapping of the host gene expression as a powerful tool in predicting possible early events in neurologic deterioration in HIV patients.
authors.affiliation: Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, the University of Sydney, Westmead, Sydney, 2145, NSW, Australia.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.forename: Viviane
authors.initials: V
authors.lastname: Conceicao
authors.forename: Priyanka
authors.initials: P
authors.lastname: Gupta
authors.forename: Nitin K
authors.initials: NK
authors.lastname: Saksena
mesh_terms: D000328:Adult; D005786:Gene Expression Regulation; D055106:Genome-Wide Association Study; D015658:HIV Infections / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D059467:Transcriptome
chemical_list: D012333:RNA, Messenger