title: Pentraxin 3, a sensitive early marker of hemodialysis-induced inflammation.
abstract: OBJECTIVE
  The purpose of this investigation was to determine if the long pentraxin 3 (PTX-3) may be a useful marker of intradialytic inflammation since it is rapidly released in the vasculature.
  
  
  METHODS
  PTX-3, interleukin-6, tumor necrosis factor-α and C-reactive protein were measured before and during a hemodialysis session in 22 patients and compared with healthy subjects. The effect of dialysis with low-flux, high-flux membranes and hemodiafiltration on the inflammatory response was compared in 11 patients.
  
  
  RESULTS
  C-reactive protein and interleukin-6 levels did not change, while a modest decrease in tumor necrosis factor-α was observed during hemodialysis. The plasma PTX-3 concentration was significantly increased (p < 0.001) after 60 min and peaked at 180 min during hemodialysis. There was no difference in the intradialytic increase in PTX-3 using different dialysis membranes and modalities.
  
  
  CONCLUSIONS
  PTX-3 stands out as a rapid and sensitive marker of hemodialysis-induced inflammation. Membrane flux and hemodiafiltration did not alter the inflammatory response.
authors.affiliation: Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Bodil
authors.initials: B
authors.lastname: Sjöberg
authors.forename: A Rashid
authors.initials: AR
authors.lastname: Qureshi
authors.forename: Björn
authors.initials: B
authors.lastname: Anderstam
authors.forename: Anders
authors.initials: A
authors.lastname: Alvestrand
authors.forename: Peter
authors.initials: P
authors.lastname: Bárány
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D017583:Hemodiafiltration / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*; D018836:Inflammation Mediators / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D013997:Time Factors; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D018836:Inflammation Mediators; D000683:Serum Amyloid P-Component; D000099153:Pentraxins