title: Central line-associated bloodstream infections in adult hematology patients with febrile neutropenia: an evaluation of surveillance definitions using differential time to blood culture positivity.
abstract: We used differential time to positivity between central and peripheral blood cultures to evaluate the positive predictive value (PPV) of the National Healthcare Safety Network central line-associated bloodstream infection (CLABSI) surveillance definition among hematology patients with febrile neutropenia. The PPV was 27.7%, which suggests that, when the definition is applied to this population, CLABSI rates will be substantially overestimated.
authors.affiliation: Department of Clinical Microbiology, Auckland District Healthboard, Auckland, New Zealand. joshuaf@adhb.govt.nz
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Freeman
authors.forename: Anna
authors.initials: A
authors.lastname: Elinder-Camburn
authors.forename: Catherine
authors.initials: C
authors.lastname: McClymont
authors.forename: Deverick J
authors.initials: DJ
authors.lastname: Anderson
authors.forename: Mary
authors.initials: M
authors.lastname: Bilkey
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Williamson
authors.forename: Leanne
authors.initials: L
authors.lastname: Berkahn
authors.forename: Sally A
authors.initials: SA
authors.lastname: Roberts
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000209:etiology* / Q000517:prevention & control; D055499:Catheter-Related Infections / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D015169:Colony Count, Microbial / Q000379:methods*; D003428:Cross Infection / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D003937:Diagnosis, Differential; D005260:Female; D006402:Hematologic Diseases / Q000150:complications* / Q000628:therapy; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D009503:Neutropenia / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D009520:New Zealand; D011159:Population Surveillance / Q000379:methods*; D011237:Predictive Value of Tests; D013997:Time Factors