title: Current management options for latent tuberculosis: a review.
abstract: Tuberculosis remains the world's second leading infectious cause of death, with nearly one-third of the global population latently infected. Treatment of latent tuberculosis infection is a mainstay of tuberculosis-control efforts in low-to medium-incidence countries. Isoniazid monotherapy has been the standard of care for decades, but its utility is impaired by poor completion rates. However, new, shorter-course regimens using rifamycins improve completion rates and are cost-saving compared with standard isoniazid monotherapy. We review the currently available therapies for latent tuberculosis infection and their toxicities and include a brief economic comparison of the different regimens.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.
authors.forename: Brianna L
authors.initials: BL
authors.lastname: Norton
authors.forename: David P
authors.initials: DP
authors.lastname: Holland