title: [Neuropsychiatric symptoms in older adults with dementia and their relationship to disease severity].
abstract: Neuropsychiatric symptoms are the psychopathological dimension of dementia and they integrate a set of symptoms among those are: personality, behavioral and basic functions changes.
  
  
  OBJECTIVE
  To analyze the prevalence of neuropsychiatric symptoms in elder people diagnosed with dementia, the association of symptoms with each other, their relationship with the severity of the disease and the stress generated by them in caregivers.
  
  
  METHODS
  Secondary data analysis of 180 cases diagnosed with dementia from a population-based cross-sectional study of 2,003 older adults living in rural and urban areas of low to medium income in Mexico.
  
  
  RESULTS
  Twelve symptoms were assessed using the Neuropsychiatric Inventory, with depression (47.8%), sleep disorders (37.2%) and irritability (34.4%) being the most prevalent ones. Statistically significant associations were found between severity of dementia and frequency of delusions, hallucinations, agitation, depression, euphoria, apathy, disinhibition, irritability and aberrant motor behavior. Anxiety, depression and sleep disorders were associated with mild/moderate caregivers stress levels. Three factors were identified by clustering technique Principal Components Analysis: the first conforming by delusions, disinhibition and euphoria; the second factor was integrated for disorders of appetite and apathy and the third factor included anxiety and aberrant motor behavior.
  
  
  CONCLUSIONS
  As in samples from other countries neuropsychiatric symptoms are common in Mexican elderly with dementia in non-institutionalized population, they may be auxiliary as indicators of severity of dementia and their grouping is related to 1) behavioral disorders, 2) vegetative symptoms and apathy, and 3) symptoms of anxiety.
authors.affiliation: Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. ixhuetzca@hotmail.com
authors.forename: Gilberto Isaac
authors.initials: GI
authors.lastname: Acosta-Castillo
authors.forename: Ana
authors.initials: A
authors.lastname: Luisa Sosa
authors.forename: Ricardo
authors.initials: R
authors.lastname: Orozco
authors.forename: Guilherme
authors.initials: G
authors.lastname: Borges
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017028:Caregivers / Q000523:psychology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003704:Dementia / Q000453:epidemiology*; D003863:Depression / Q000453:epidemiology; D001068:Feeding and Eating Disorders / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D008800:Mexico / Q000453:epidemiology; D019964:Mood Disorders / Q000453:epidemiology; D009069:Movement Disorders / Q000453:epidemiology; D009422:Nervous System Diseases / Q000453:epidemiology*; D015995:Prevalence; D012424:Rural Population / Q000706:statistics & numerical data; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000453:epidemiology; D013315:Stress, Psychological / Q000453:epidemiology / Q000209:etiology; D014505:Urban Population / Q000706:statistics & numerical data