title: The effect of lung-size mismatch on mechanical ventilation tidal volumes after bilateral lung transplantation.
abstract: OBJECTIVE
  Mechanical ventilation tidal volumes are usually set according to an estimate of patient size in millilitres (ml) per kilogram (kg) body weight. We describe the relationship between donor-recipient lung-size mismatch and postoperative mechanical ventilation tidal volumes according to recipient- and donor-predicted body weights in a cohort of bilateral lung transplant patients.
  
  
  METHODS
  A most-undersized (10 patients with lowest predicted total lung capacity [pTLC] ratio = pTLC-donor/pTLC-recipient), a most-oversized (10 patients with highest pTLC ratio) and best-matched subset (10 patients with predicted total lung capacity ratio closest to 1.0) were selected within a cohort of 70 patients. All tidal volumes during mechanical ventilation in the first 96 h after bilateral lung transplantation were recorded. Tidal volumes were expressed in ml and ml/kg-recipient-predicted body weights and ml/kg-donor-predicted body weights.
  
  
  RESULTS
  Postoperative absolute tidal volumes (in ml) were comparable between subsets of patients with undersized, matched and oversized allografts (552 ± 103 vs 581 ± 107 vs 582 ± 104 ml), and tidal volumes in ml/kg-recipient-predicted body weights were also similar (8.8 ± 1.4 vs 9.3 ± 1.1 vs 9.8 ± 2.1). However, tidal volumes in ml/kg-donor-predicted body weights revealed significant differences between undersized, matched, and oversized subsets (11.4 ± 3.1 vs 9.4 ± 1.2 vs 8.1 ± 2.1, respectively; P < 0.05). Two patients developed primary graft dysfunction grade 3, both in the undersized subset. Four patients in the undersized group underwent tracheotomy (vs none in matched and one in oversized subset).
  
  
  CONCLUSIONS
  During mechanical ventilation after bilateral lung transplantation, undersized allografts received relatively higher tidal volumes compared with oversized allografts when the tidal volumes were related to donor-predicted body weights.
authors.affiliation: Division of Pulmonary and Critical Care Medicine,  Johns Hopkins University School of Medicine Baltimore, Baltimore, MD,  USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Dezube
authors.forename: George J
authors.initials: GJ
authors.lastname: Arnaoutakis
authors.forename: Robert M
authors.initials: RM
authors.lastname: Reed
authors.forename: Servet
authors.initials: S
authors.lastname: Bolukbas
authors.forename: Ashish S
authors.initials: AS
authors.lastname: Shah
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Orens
authors.forename: Roy G
authors.initials: RG
authors.lastname: Brower
authors.forename: Michael
authors.initials: M
authors.lastname: Eberlein
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001835:Body Weight; D001989:Bronchiolitis Obliterans / Q000209:etiology / Q000503:physiopathology; D046148:Donor Selection; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008168:Lung / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008171:Lung Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016040:Lung Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D055031:Primary Graft Dysfunction / Q000209:etiology / Q000503:physiopathology; D012086:Reoperation; D012121:Respiration, Artificial / Q000009:adverse effects; D012307:Risk Factors; D013990:Tidal Volume; D013997:Time Factors; D014109:Total Lung Capacity; D014140:Tracheotomy; D016896:Treatment Outcome