title: An overview on bone protein extract as the new generation of demineralized bone matrix.
abstract: Bone protein extract is regarded as the new generation of demineralized bone matrix. The aim of this paper is to describe and characterize the properties of demineralized bone matrix and its new generation product in addition to its application in animal and human studies. Bone protein extract has features of osteoconductivity, osteoinductivity and osteogenicity, which originate from its unique and precise processing. It has exhibited powerful bone formation capacity both in animal experiments and in clinical trials by providing an optimal microenvironment for osteogenesis. Furthermore, not only does it have excellent biocompatibility, it also has good compatibility with other implant materials, helping it bridge the host and implanted materials. Bone protein extract could be a promising alternative for demineralized bone matrix as a bone graft substitute.
authors.affiliation: Orthopaedic Research Institute/Department of Orthpaedic Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Zhou
authors.forename: Lijin
authors.initials: L
authors.lastname: Zou
authors.forename: Haisheng
authors.initials: H
authors.lastname: Li
authors.forename: Cody
authors.initials: C
authors.lastname: Bünger
authors.forename: Xuenong
authors.initials: X
authors.lastname: Zou
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D008903:Minerals / Q000378:metabolism*; D011506:Proteins / Q000302:isolation & purification* / Q000378:metabolism; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D008903:Minerals; D011506:Proteins