title: A carbon nanofiber based biosensor for simultaneous detection of dopamine and serotonin in the presence of ascorbic acid.
abstract: A biosensor based on an array of vertically aligned carbon nanofibers (CNFs) grown by plasma enhanced chemical vapor deposition is found to be effective for the simultaneous detection of dopamine (DA) and serotonin (5-HT) in the presence of excess ascorbic acid (AA). The CNF electrode outperforms the conventional glassy carbon electrode (GCE) for both selectivity and sensitivity. Using differential pulse voltammetry (DPV), three distinct peaks are seen for the CNF electrode at 0.13 V, 0.45 V, and 0.70 V for the ternary mixture of AA, DA, and 5-HT. In contrast, the analytes are indistinguishable in a mixture using a GCE. For the CNF electrode, the detection limits are 50 nM for DA and 250 nM for 5-HT.
authors.affiliation: Center for Nanotechnology, NASA Ames Research Center, Moffett Field, CA 94035, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Rand
authors.forename: Adaikkappan
authors.initials: A
authors.lastname: Periyakaruppan
authors.forename: Zuki
authors.initials: Z
authors.lastname: Tanaka
authors.forename: David A
authors.initials: DA
authors.lastname: Zhang
authors.forename: Michael P
authors.initials: MP
authors.lastname: Marsh
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Andrews
authors.forename: Kendall H
authors.initials: KH
authors.lastname: Lee
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Meyyappan
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Koehne
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D002244:Carbon / Q000737:chemistry; D004298:Dopamine / Q000737:chemistry / Q000302:isolation & purification*; D006863:Hydrogen-Ion Concentration; D057139:Nanofibers / Q000737:chemistry; D037742:Nanotubes, Carbon; D012701:Serotonin / Q000737:chemistry / Q000302:isolation & purification*; D014527:Uric Acid / Q000737:chemistry
chemical_list: D037742:Nanotubes, Carbon; D014527:Uric Acid; D012701:Serotonin; D002244:Carbon; D001205:Ascorbic Acid; D004298:Dopamine