title: The emergence of HIV-1 primary drug resistance genotypes among treatment-naïve men who have sex with men in high-prevalence areas in China.
abstract: The prevalence of HIV-1 infection in men who have sex with men (MSM) in China has drastically increased, and circulating strains may have acquired transmitted drug resistance (TDR). We determined TDR genotypes among antiretroviral therapy (ART)-naïve MSM in 19 provinces/cities where HIV-1 prevalence among MSM is high, and found an overall 4.9 % TDR rate. Although protease inhibitors (PI) were not in the first-line antiretroviral drug list provided through the National ART Program, 70.4 % of the detected TDR belongs to this category. Our findings confirm the urgent need for TDR surveillance in order to optimize treatment effects of the National ART Program.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. gracefulyang@163.com
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.forename: Jianli
authors.initials: J
authors.lastname: Niu
authors.forename: Lingjie
authors.initials: L
authors.lastname: Liao
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Ruan
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Zhe
authors.initials: Z
authors.lastname: Li
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D024882:Drug Resistance, Viral / Q000235:genetics; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D009154:Mutation; D010802:Phylogeny; D015995:Prevalence
chemical_list: D019380:Anti-HIV Agents