title: Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp.
abstract: In the course of screening for breast cancer cell migration inhibitors, we isolated two novel compounds, migracins A and B from the culture broth of Streptomyces sp. MI264-NF2. Their structures are related to those of luminacins previously isolated from Streptomyces. Migracins A and B inhibited breast cancer cell migration, monitored by wound healing assay with IC50 values of 1.31 and 1.99 μg ml(-1), respectively, in human breast carcinoma MDA-MB-231 cells without showing any cytotoxicity. Migracins also inhibited the migration of human lung adenocarcinoma A549 cells and human fibrosarcoma HT-1080 cells. Therefore, migracins may become new cancer metastasis inhibitors.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Arai
authors.forename: Hironobu
authors.initials: H
authors.lastname: Iinuma
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Igarashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Hatano
authors.forename: Naoko
authors.initials: N
authors.lastname: Kinoshita
authors.forename: Tamami
authors.initials: T
authors.lastname: Ukaji
authors.forename: Siro
authors.initials: S
authors.lastname: Simizu
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umezawa
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001547:Benzaldehydes / Q000302:isolation & purification* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; D001547:Benzaldehydes; D016328:NF-kappa B; C582003:migracin A; C582002:migracin B