title: A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention.
abstract: Given the link between depression, anxiety, and cannabis abuse, a serotonin receptor (rs6311) and transporter polymorphism (rs2020936) were examined as moderators of neural response as measured by functional magnetic resonance imaging following a psychosocial treatment for cannabis use disorders (CUDs). While the proposed hypotheses were unsupported, we found that the rs6311 C allele was significantly related to brain activation (medial frontal gyrus, precuneus), indicating the role of this serotonin receptor in adolescent treatment response.
authors.affiliation: University of New Mexico Center on Alcohol and Substance Abuse Addictions, 1 University of New Mexico, MSC06 3890, Albuquerque, NM 87131, USA. swfeld@unm.edu
authors.forename: Sarah W
authors.initials: SW
authors.lastname: Feldstein Ewing
authors.forename: Hilary K
authors.initials: HK
authors.lastname: Mead
authors.forename: Uma
authors.initials: U
authors.lastname: Yezhuvath
authors.forename: Sam
authors.initials: S
authors.lastname: Dewitt
authors.forename: Kent E
authors.initials: KE
authors.lastname: Hutchison
authors.forename: Francesca M
authors.initials: FM
authors.lastname: Filbey
mesh_terms: D000293:Adolescent; D001526:Behavioral Symptoms / Q000209:etiology / Q000235:genetics; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D015928:Cognitive Behavioral Therapy / Q000379:methods; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D002189:Marijuana Abuse / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000534:rehabilitation; D010100:Oxygen / Q000097:blood; D011110:Polymorphism, Genetic / Q000235:genetics*; D011985:Receptors, Serotonin / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D011985:Receptors, Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D010100:Oxygen