title: Diagnostic methods for invasive fungal diseases in patients with hematologic malignancies.
abstract: Invasive fungal disease is associated with increased morbidity and mortality in hematologic malignancy patients and hematopoietic stem cell transplant recipients. Timely recognition and treatment of invasive fungal diseases in these patients are essential and decrease mortality. However, conventional definitive diagnostic methods are difficult and time consuming. While conventional microbiological and histopathological methods are still needed for a definitive diagnosis of invasive fungal disease, new noninvasive diagnostic methods including serologic and molecular biomarkers are now available. These new diagnostic methods facilitate an early diagnosis of invasive fungal disease and allow for utilization of a pre-emptive treatment approach, which may ultimately lead to improved treatment outcomes and reduced toxicity.
authors.affiliation: University of Florida, College of Medicine, Division of Hematology/Oncology 1600 W Archer Road, Gainesville, FL 32610-0278, USA.
authors.forename: Mary Mansour
authors.initials: MM
authors.lastname: Riwes
authors.forename: John R
authors.initials: JR
authors.lastname: Wingard
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000382:microbiology*; D006801:Humans; D009181:Mycoses / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents