title: Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia.
abstract: It has been revealed that the Wnt/β-catenin signaling pathway plays an important role in the development of solid tumors and hematological malignancies, particularly in B-cell neoplasia and leukemia. In the last decade there have been made experimental approaches targeting the Wnt pathway in chronic leukemia. In this paper we provide an overview about the current state of knowledge regarding the Wnt/β-catenin signaling pathway in chronic leukemia with special focus on therapeutic options and strategies.
authors.affiliation: Department of Internal Medicine III (Hematology and Oncology), Center for Integrated Oncology (CIO), University of Bonn, Sigmund-Freud Stra β e 25, 53127 Bonn, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Thanendrarajan
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: I G H
authors.initials: IG
authors.lastname: Schmidt-Wolf