title: Amyloid beta accumulation in HIV-1-infected brain: The role of the blood brain barrier.
abstract: In recent years, we face an increase in the aging of the HIV-1-infected population, which is not only due to effective antiretroviral therapy but also to new infections among older people. Even with the use of the antiretroviral therapy, HIV-associated neurocognitive disorders represent an increasing problem as the HIV-1-infected population ages. Increased amyloid beta (Aβ) deposition is characteristic of HIV-1-infected brains, and it has been hypothesized that brain vascular dysfunction contributes to this phenomenon, with a critical role suggested for the blood-brain barrier in brain Aβ homeostasis. This review will describe the mechanisms by which the blood-brain barrier may contribute to brain Aβ accumulation, and our findings in the context of HIV-1 infection will be discussed.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL, USA. IAndras@med.miami.edu
authors.forename: Ibolya E
authors.initials: IE
authors.lastname: András
authors.forename: Michal
authors.initials: M
authors.lastname: Toborek
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D015658:HIV Infections / Q000378:metabolism*; D015497:HIV-1; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D011509:Proteoglycans