title: Structure-based drug discovery for botulinum neurotoxins.
abstract: Clostridium botulinum neurotoxin is the most poisonous substance known to humans. It is a potential biowarfare threat and a public health hazard. The only therapeutics available is antibody treatment which will not be effective for post-exposure therapy. There are no drugs available for post-intoxication treatment. Accordingly, it is imperative to develop effective drugs to counter botulism. Available structural information on botulinum neurotoxins both alone and in complex with their substrates offers an efficient method for designing structure-based drugs to treat botulism.
authors.affiliation: Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. swami@bnl.gov
authors.forename: Subramanyam
authors.initials: S
authors.lastname: Swaminathan
mesh_terms: D000818:Animals; D001905:Botulinum Toxins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000633:toxicity; D001906:Botulism / Q000188:drug therapy* / Q000382:microbiology; D020134:Catalytic Domain; D003014:Clostridium botulinum / Q000737:chemistry* / Q000472:pathogenicity; D055808:Drug Discovery / Q000379:methods*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000737:chemistry; D009498:Neurotoxins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000633:toxicity; D010455:Peptides / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000494:pharmacology; D025941:Protein Interaction Mapping; D059748:Proteolysis; D055672:Static Electricity
chemical_list: D004791:Enzyme Inhibitors; D046912:Multiprotein Complexes; D009498:Neurotoxins; D010455:Peptides; D001905:Botulinum Toxins