title: Serum leptin and total dietary energy intake: the INTERLIPID Study.
abstract: OBJECTIVE
  It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese-Americans in Hawaii and Japanese in Japan.
  
  
  METHODS
  Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40-59 years from two population samples, one Japanese-American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (<25 kg/m(2), 25-29.9 kg/m(2), and ≥ 30 kg/m(2)) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake.
  
  
  RESULTS
  In multivariate regression analyses, in those with BMI < 25 kg/m(2) and in those with BMI between 25 and 29.9 kg/m(2), log-leptin was not significantly related to total dietary energy intake; in those with BMI ≥ 30 kg/m(2), it was significantly inversely related to total dietary energy intake (P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI < 25 kg/m(2) (P < 0.001).
  
  
  CONCLUSIONS
  Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons.
authors.affiliation: Cardiovascular Epidemiology, Kyoto Women's University, 35 Imakumano Kitahiyoshi-cho, Higashiyama-ku, Kyoto, Kyoto 605-8501, Japan. nakamury@kyoto-wu.ac.jp
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueshima
authors.forename: Nagako
authors.initials: N
authors.lastname: Okuda
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Murakami
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Miura
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Kita
authors.forename: Tomonori
authors.initials: T
authors.lastname: Okamura
authors.forename: Akira
authors.initials: A
authors.lastname: Okayama
authors.forename: Tanvir C
authors.initials: TC
authors.lastname: Turin
authors.forename: Sohel R
authors.initials: SR
authors.lastname: Choudhry
authors.forename: Beatriz
authors.initials: B
authors.lastname: Rodriguez
authors.forename: J
authors.initials: J
authors.lastname: David Curb
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Stamler
mesh_terms: D000328:Adult; D001066:Appetite / Q000187:drug effects; D001213:Asian; D044466:Asian People; D015992:Body Mass Index; D001835:Body Weight; D003430:Cross-Sectional Studies; D002149:Energy Intake; D005260:Female; D006254:Hawaii; D006801:Humans; D007564:Japan; D020738:Leptin / Q000097:blood*; D008019:Life Style; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000097:blood; D050177:Overweight / Q000097:blood
chemical_list: D020738:Leptin