title: The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis.
abstract: The Wnt signaling pathway is involved in the development and progression of many human cancers, yet attempts to target the pathway therapeutically have been disappointing to date. The recent discovery that the ROR2 receptor tyrosine kinase (RTK) is a novel Wnt receptor provides the potential to target the non-canonical Wnt pathway for cancer treatments. As a member of the RTK superfamily of surface receptors ROR2 appears to possess dual roles as a tumor suppressor or activator depending on tumor type. This review will explore the dual role of ROR2 in tumorigenesis and provide an up to date analysis of current literature in this rapidly expanding field.
authors.affiliation: Wnt Signaling & Metastasis Group, Lowy Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Australia. caroline.ford@unsw.edu.au
authors.forename: Caroline E
authors.initials: CE
authors.lastname: Ford
authors.forename: Sean Si
authors.initials: SS
authors.lastname: Qian Ma
authors.forename: Ashfaque
authors.initials: A
authors.lastname: Quadir
authors.forename: Robyn L
authors.initials: RL
authors.lastname: Ward
mesh_terms: D002471:Cell Transformation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000502:physiology*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D051153:Wnt Proteins; C078717:ROR2 protein, human; D057050:Receptor Tyrosine Kinase-like Orphan Receptors