title: Spinal deformity index in patients with type 2 diabetes.
abstract: The objective of this study is to investigate bone metabolism, density, and quality in patients with diabetes type 2 using DEXA and spinal deformity index (SDI), a surrogate index of bone quality. Fifty-six patients with type 2 diabetes were studied; exclusion criteria were diseases and medications that affect bone and mineral metabolism. Mean age was 65 ± 7 years. Mean diabetes duration was 10 ± 7 years and mean HbA1C was 6.6 ± 0.5 %. BMI was 30 ± 4. Fifty-six sex, age, and BMI matched served as controls. All subjects underwent a clinical and biochemical examination. Spinal and femoral neck BMD were measured by DEXA, and a spine radiography was performed to assess vertebral fractures and to calculate SDI. Mean serum 25-OH vitamin D levels were 19.6 ± 3.7 ng/ml in patients and 30 ± 14 ng/ml in controls (p < 0.01). PTH serum levels were 47.9 ± 40 pg/ml in patients versus 37 ± 5.3 pg/ml in controls (p < 0.01). At lumbar spine there was a significant difference between patients and controls only for T-score (p = <0.01), while at femoral neck there was a difference in BMD (p < 0.01) and in T-score (p < 0.01). Radiological vertebral fractures were found in 46 % of patients and 17 % of controls (p < 0.05). SDI was higher in patients than in controls (p < 0.05). The percentage of fractures with T-score BMD greater than -2.5 was 69 % in patients and 10 % in controls (p < 0.05). As a conclusion, BMD was similar in patients and in controls, while SDI value was higher in patients; therefore, SDI was more specific than BMD for the diagnosis of osteoporosis due to metabolic diseases.
authors.affiliation: SDN Foundation Naples, Naples, Italy. cdisomma@unina.it
authors.forename: C
authors.initials: C
authors.lastname: Di Somma
authors.forename: M
authors.initials: M
authors.lastname: Rubino
authors.forename: A
authors.initials: A
authors.lastname: Faggiano
authors.forename: L
authors.initials: L
authors.lastname: Vuolo
authors.forename: P
authors.initials: P
authors.lastname: Contaldi
authors.forename: N
authors.initials: N
authors.lastname: Tafuri
authors.forename: N
authors.initials: N
authors.lastname: Tafuto
authors.forename: M
authors.initials: M
authors.lastname: Andretti
authors.forename: S
authors.initials: S
authors.lastname: Savastano
authors.forename: A
authors.initials: A
authors.lastname: Colao
mesh_terms: D000368:Aged; D015519:Bone Density; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D010281:Parathyroid Hormone / Q000097:blood; D011859:Radiography; D016103:Spinal Fractures / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D