title: In elderly patients with AML, which patients should be considered fit or unfit for standard induction therapy?
abstract: A 75-year-old man visits his primary care physician for a routine checkup and a complete blood count reveals pancytopenia. BM examination confirms the diagnosis of acute myeloid leukemia. No dysplastic features were noted and his karyotype results are pending. The patient has well-controlled hypertension and his last hospital admission was 20 years ago for repair of a rotator cuff injury. His Eastern Cooperative Oncology Group performance status is 0/4 and he has no cognitive impairment. You believe the patient is fit for standard acute myeloid leukemia induction, but you are concerned because of his older age and you are considering less-intensive approaches.
authors.affiliation: Sylvester Comprehensive Cancer Center, Division of Hematology/Oncology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. rswords@med.miami.edu
authors.forename: Ronan
authors.initials: R
authors.lastname: Swords
authors.forename: Valeria
authors.initials: V
authors.lastname: Santini
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging; D015897:Comorbidity; D006405:Hematology / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000150:complications; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D008495:Medical Oncology / Q000379:methods; D020360:Neoadjuvant Therapy / Q000379:methods; D012074:Remission Induction; D012189:Retrospective Studies; D012306:Risk; D016896:Treatment Outcome