title: [A case report of complete response to low-dose S-1 monotherapy for pancreatic cancer in elderly patient].
abstract: A 87-year-old woman was diagnosed with pancreatic body cancer(Stage II ). Because of her age and history of open distal partial gastrectomy, it seemed that having her undergo an invasive surgery would be difficult. Therefore, S-1 was administered orally at a dose of 50mg/day for 28 consecutive days followed by a 14-day rest course(low-dose S-1 monotherapy). After 2 courses, the tumor marker(CA19-9)dramatically decreased to within the normal range. After 5 courses, the tumor could not be identified on the abdominal CT image, and it was judged to be a complete response. Low-dose S-1 monotherapy may be useful for improving the prognosis of pancreatic cancer without causing intolerable toxicity, especially for elderly patients.
authors.affiliation: Dept. of Surgery, Kawamura Hospital, Japan.
authors.forename: Rikiya
authors.initials: R
authors.lastname: Sato
authors.forename: Muneo
authors.initials: M
authors.lastname: Kawamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawamura
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Sasaki
authors.forename: Takuro
authors.initials: T
authors.lastname: Ushigome
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nyumura
mesh_terms: D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D004338:Drug Combinations; D005260:Female; D006801:Humans; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D014408:Biomarkers, Tumor; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid