title: Effect of thiazolidine LPSF SF29 on the growth and morphology of Trypanosoma cruzi.
abstract: Chagas disease, caused by the protozoan Trypanosoma cruzi, is an endemic illness in Latin America. Efforts have been made by several groups to develop new effective and safe anti-T. cruzi drugs. In the present work, we show that thiazolidine LPSF SF29 inhibited growth of the epimastigote and amastigote forms and caused lysis in the trypomastigote form of T. cruzi, leading to death of the protozoan. Mitochondrial dysfunction was also observed. The thiazolidine induced ultrastructural alterations such as detachment of the flagellar membrane, intense mitochondrial swelling, formation of myelin-like figures and the appearance of autophagosomes. Taken together, these results suggest that this new thiazolidine is active against T. cruzi and constitutes a promising drug for the therapy of Chagas disease.
authors.affiliation: Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, CEP 21949-900, Brazil.
authors.forename: Thiago Luiz
authors.initials: TL
authors.lastname: de B Moreira
authors.forename: Artur F S
authors.initials: AF
authors.lastname: Barbosa
authors.forename: Phercyles
authors.initials: P
authors.lastname: Veiga-Santos
authors.forename: Cristina
authors.initials: C
authors.lastname: Henriques
authors.forename: Andrea
authors.initials: A
authors.lastname: Henriques-Pons
authors.forename: Suely L
authors.initials: SL
authors.lastname: Galdino
authors.forename: Maria do Carmo A
authors.initials: Mdo C
authors.lastname: de Lima
authors.forename: Ivan da R
authors.initials: Ida R
authors.lastname: Pitta
authors.forename: Wanderley
authors.initials: W
authors.lastname: de Souza
authors.forename: Tecia Maria U
authors.initials: TM
authors.lastname: de Carvalho
mesh_terms: D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007843:Latin America; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology; D053778:Thiazolidines / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure
chemical_list: D000981:Antiprotozoal Agents; D053778:Thiazolidines