title: Infections acquired by adults who receive extracorporeal membrane oxygenation: risk factors and outcome.
abstract: OBJECTIVE
  To analyze infectious complications that occur in patients who receive extracorporeal membrane oxygenation (ECMO), associated risk factors, and consequences on patient outcome.
  
  
  METHODS
  Retrospective observational survey from 2005 through 2011.
  
  
  METHODS
  Patients who required ECMO in an Australian referral center.
  
  
  METHODS
  Cases of bloodstream infection (BSI), catheter-associated urinary tract infection (CAUTI), and ventilator-associated pneumonia (VAP) that occurred in patients who received ECMO were analyzed.
  
  
  RESULTS
  A total of 146 ECMO procedures were performed for more than 48 hours in 139 patients, and 36 patients had a total of 46 infections (30.1 infectious episodes per 1,000 days of ECMO). They included 24 cases of BSI, 6 of them secondary to VAP; 23 cases of VAP; and 5 cases of CAUTI. The most frequent pathogens were Enterobacteriaceae (found in 16 of 46 cases), and Candida was the most common cause of BSI (in 9 of 24 cases). The Sequential Organ Failure Assessment score before ECMO initiation and the number of days of support were independently associated with a risk of BSI, with odds ratios of 1.23 (95% confidence interval [CI], 1.03-1.47; [Formula: see text]) and 1.08 (95% CI, 1.03-1.19]; [Formula: see text]), respectively. Infected patients did not have a significantly higher mortality compared with uninfected patients (41.7% vs 32%; [Formula: see text]), but intensive care unit length of stay (16 days [interquartile range, 8-26 days] vs 11 days [IQR, 4-19 days]; [Formula: see text]) and hospital length of stay (33.5 days [interquartile range, 15.5-55.5] vs 24 days [interquartile range, 9-42 days]; [Formula: see text]) were longer.
  
  
  CONCLUSIONS
  The probability of infection increased with the duration of support and the severity of illness before initiation of ECMO. Infections affected length of stay but did not have an impact on mortality.
authors.affiliation: Intensive Care Unit, Alfred Hospital, Melbourne, Australia. cecile.aubron@monash.edu
authors.forename: Cecile
authors.initials: C
authors.lastname: Aubron
authors.forename: Allen C
authors.initials: AC
authors.lastname: Cheng
authors.forename: David
authors.initials: D
authors.lastname: Pilcher
authors.forename: Tim
authors.initials: T
authors.lastname: Leong
authors.forename: Geoff
authors.initials: G
authors.lastname: Magrin
authors.forename: D Jamie
authors.initials: DJ
authors.lastname: Cooper
authors.forename: Carlos
authors.initials: C
authors.lastname: Scheinkestel
authors.forename: Vince
authors.initials: V
authors.lastname: Pellegrino
mesh_terms: D000328:Adult; D001315:Australia / Q000453:epidemiology; D058387:Candidemia / Q000453:epidemiology; D055499:Catheter-Related Infections / Q000453:epidemiology / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D053717:Pneumonia, Ventilator-Associated / Q000453:epidemiology / Q000382:microbiology; D012189:Retrospective Studies; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000382:microbiology