title: [Optimize technique of extracting alpha-mangostin from pericarp of Garcinia mangostana by supersonic wave using central composite design-response surface methodology].
abstract: OBJECTIVE
  To optimize the extraction technique for alpha-mangostin from pericarp of Garcinia Mangostana.
  
  
  METHODS
  The effects of ethanol concentration, ultrasonic extraction time, the liquid to solid ratio and their interaction on extraction rate were studied by central composite design. The predictive model and reliability were developed by SAS software and response surface analysis. The optimal ultrasonic extraction conditions were achieved.
  
  
  RESULTS
  The optimal ultrasonic extraction conditions were as follows: ethanol concentration 67.8%, ultrasonic extraction time 85.9 min, the liquid to solid ratio 24.2 mL/g. Under the optimum conditions, the extraction yield of alpha-mangostin was 5.53%.
  
  
  CONCLUSIONS
  This study provides an effective method for the industrial extraction of alpha-mangostin.
authors.affiliation: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. zhyjlu79@163.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Tang
authors.forename: Da-Ming
authors.initials: DM
authors.lastname: Jin
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Lian-Xue
authors.initials: LX
authors.lastname: Zhang
mesh_terms: D002851:Chromatography, High Pressure Liquid; D000431:Ethanol / Q000737:chemistry; D005638:Fruit / Q000737:chemistry*; D029762:Garcinia mangostana / Q000737:chemistry*; D008962:Models, Theoretical; D012044:Regression Analysis; D015203:Reproducibility of Results; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors; D014465:Ultrasonics; D044004:Xanthones / Q000032:analysis / Q000302:isolation & purification*
chemical_list: D044004:Xanthones; D000431:Ethanol; C021053:mangostin