title: Antimicrobials, drug discovery, and genome mining.
abstract: Over the years, antibiotics have provided an effective treatment for a number of microbial diseases. However recently, there has been an increase in resistant microorganisms that have adapted to our current antibiotics. One of the most dangerous pathogens is methicillin-resistant Staphylococcus aureus (MRSA). With the rise in the cases of MRSA and other resistant pathogens such as vancomycin-resistant Staphylococcus aureus, the need for new antibiotics increases every day. Many challenges face the discovery and development of new antibiotics, making it difficult for these new drugs to reach the market, especially since many of the pharmaceutical companies have stopped searching for antibiotics. With the advent of genome sequencing, new antibiotics are being found by the techniques of genome mining, offering hope for the future.
authors.affiliation: Research Institute for Scientists Emeriti (R.I.S.E.), Drew University, 07940, Madison, NJ, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Scheffler
authors.forename: S
authors.initials: S
authors.lastname: Colmer
authors.forename: H
authors.initials: H
authors.lastname: Tynan
authors.forename: A L
authors.initials: AL
authors.lastname: Demain
authors.forename: V P
authors.initials: VP
authors.lastname: Gullo
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D019295:Computational Biology / Q000379:methods*; D057225:Data Mining; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D024881:Drug Resistance, Bacterial; D023281:Genomics / Q000379:methods*; D006801:Humans
chemical_list: D000890:Anti-Infective Agents