title: Three cases of perioral dermatitis related to fusobacteria treated with β-lactam antibiotics.
abstract: BACKGROUND
  The oral tetracyclines, especially minocycline hydrochloride, are often used as an effective treatment for perioral dermatitis; however, they are sometimes difficult to use, especially in children, because of the side effects.
  
  
  OBJECTIVE
  The effectiveness of β-lactam antibiotics was evaluated in three cases of perioral dermatitis.
  
  
  METHODS
  Three Japanese patients with perioral dermatitis were treated with cefcapene pivoxil hydrochloride hydrate per os 100-300 mg/day. They were one girl (aged 10 years) and two adult women (aged 32 and 37 years respectively). One of the adult patients had a past history of Meniere's disease and the other had had a side effect, vertigo, from minocycline hydrochloride treatment. The presence of fusobacteria before and after the treatment was examined using the tape-stripping toluidine blue method.
  
  
  RESULTS
  These patients showed the improvement in 1-2 weeks and were much improved or cured after 2-5 weeks. No side effects were found during the treatment. Fusobacteria were positive before treatment but became negative after the treatment in all of them.
  
  
  CONCLUSIONS
  The β-lactam antibiotics might be a useful treatment for perioral dermatitis, especially in cases who cannot take tetracyclines.
authors.affiliation: Department of Dermatology, Tokyo Women's Medical University , Tokyo , Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ishiguro
authors.forename: Azusa
authors.initials: A
authors.lastname: Maeda
authors.forename: Kaoru
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Yamana
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Fukuya
authors.forename: Makoto
authors.initials: M
authors.lastname: Kawashima
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002511:Cephalosporins / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D019557:Dermatitis, Perioral / Q000188:drug therapy* / Q000209:etiology* / Q000382:microbiology; D005260:Female; D005674:Fusobacterium Infections / Q000188:drug therapy*; D006801:Humans; D016896:Treatment Outcome; D047090:beta-Lactams / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D047090:beta-Lactams; C425944:cefcapene pivoxil hydrochloride