title: Plasma viscosity: is a biomarker for the differential diagnosis of Alzheimer's disease and vascular dementia?
abstract: In this study, the importance of plasma viscosity (PV) as a biomarker in differential diagnosis of dementia subtypes especially Alzheimer's disease (AD) and vascular dementia (VaD) was investigated. Our study recruited 45 patients with AD, 35 patients with VaD, and control participants. Individuals with inflammatory disease, infection, heart, liver, renal failure, and with high erythrocyte sedimentation rate and C-reactive protein levels were excluded from the study. The cases underwent comprehensive geriatric assessment. The PV measurements were performed with Brookfield DV-II viscometer. The PV measurements of AD, VaD, and control groups were 1.61 ± 0.08, 1.70 ± 0.06, and 1.48 ± 0.06 mPa S, respectively. The PV levels of the dementia group were significantly higher than the control group (P < .001). When the dementia group was analyzed by itself, patients with VaD had higher PV levels than the patients with AD (P < .001). The PV is a biomarker to be used in diagnosis as well as in differentiating between the 2 most common forms of dementia which are AD and VaD.
authors.affiliation: Department of Geriatric Medicine, Ankara University School of Medicine, Mamak street, Cebeci, Ankara, Turkey. sevgidursun06@yahoo.com
authors.forename: Sevgi
authors.initials: S
authors.lastname: Aras
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Tek
authors.forename: Murat
authors.initials: M
authors.lastname: Varli
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yalcin
authors.forename: Ozlem Karaarslan
authors.initials: OK
authors.lastname: Cengiz
authors.forename: Volkan
authors.initials: V
authors.lastname: Atmis
authors.forename: Teslime
authors.initials: T
authors.lastname: Atli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D001809:Blood Viscosity / Q000502:physiology*; D003430:Cross-Sectional Studies; D015140:Dementia, Vascular / Q000097:blood* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales
chemical_list: D015415:Biomarkers