title: Synthesis, spectroscopic investigations, antimicrobial and DNA binding studies of a new charge transfer complex of o-phenylenediamine with 3,5-dinitrosalicylic acid.
abstract: A charge transfer complex of o-phenylenediamine (OPD) as donor with 3,5-dinitrosalicylic acid (DNSH) as acceptor, was synthesized and characterized by FTIR, (1)H NMR, (13)C NMR, mass spectroscopy, elemental analysis and X-ray crystallography. The structural investigations exhibit that the cation and anion are joined together by strong N(+)H⋯O(-) type hydrogen bonds and stoichiometry of CT complex was found to be 1:1. The CT (charge transfer) complex shows remarkable interaction with Calf thymus DNA, and the CT complex was also screened for its microbial activity such as antimicrobial and antifungal activities. A molecular frame work through H-bonding interactions via n→π(*) transitions between neighboring moieties is found which is responsible for high melting point of resulting CT complex. This has been attributed to the formation of 1:1 CT complex.
authors.affiliation: Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh 202 002, India. drishaatamu@gmail.com
authors.forename: Ishaat M
authors.initials: IM
authors.lastname: Khan
authors.forename: Afaq
authors.initials: A
authors.lastname: Ahmad
authors.forename: M F
authors.initials: MF
authors.lastname: Ullah
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002417:Cattle; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009181:Mycoses / Q000188:drug therapy; D010655:Phenylenediamines / Q000737:chemistry* / Q000494:pharmacology*; D012459:Salicylates / Q000737:chemistry* / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000890:Anti-Infective Agents; D010655:Phenylenediamines; D012459:Salicylates; C027011:3,5-dinitrosalicylic acid; C034193:1,2-diaminobenzene; D004247:DNA; C427203:calf thymus DNA