title: The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington's disease: a pilot study.
abstract: OBJECTIVE
  Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small cohort of patients with early-to-middle-stage HD.
  
  
  METHODS
  Twenty patients with HD were assigned to two groups, equally matched for cognitive and motor scores. One group received the intervention, whilst the other served as control. The Unified-Huntington's-Disease-Rating-Scale-Total-Motor-Score was the primary outcome measure. Neurocognitive/psychological tests, body composition, postural stability, strength and quality of life assessments were secondary outcome measures.
  
  
  RESULTS
  The intervention reduced motor and postural stability deterioration, with minor improvements in depression, cognition and quality of life. Significant gains were observed for fat-free mass and strength.
  
  
  CONCLUSIONS
  This pilot study suggests that a prolonged multidisciplinary rehabilitation programme in early-to-middle-stage HD is feasible, well-tolerated and associated with therapeutic benefit. Further explorative, larger studies are warranted.
authors.affiliation: School of Medical Sciences, Edith Cowan University, Perth, Australia. jennifer.thompson@ecu.edu.au
authors.forename: J A
authors.initials: JA
authors.lastname: Thompson
authors.forename: T M
authors.initials: TM
authors.lastname: Cruickshank
authors.forename: L E
authors.initials: LE
authors.lastname: Penailillo
authors.forename: J W
authors.initials: JW
authors.lastname: Lee
authors.forename: R U
authors.initials: RU
authors.lastname: Newton
authors.forename: R A
authors.initials: RA
authors.lastname: Barker
authors.forename: M R
authors.initials: MR
authors.lastname: Ziman
mesh_terms: D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D009788:Occupational Therapy / Q000379:methods*; D010865:Pilot Projects; D016896:Treatment Outcome