title: A polyacetylene-rich extract from Gymnaster koraiensis strongly inhibits colitis-associated colon cancer in mice.
abstract: Gymnaster koraiensis (GK) is a Korean herb used in folk medicine and recently found to positively impact liver health. Because GK contains polyacetylenes and because other polyacetylenes have been found to exhibit anti-inflammatory and anti-cancer activities, we hypothesized that the polyacetylene gymnasterkoreayne B (GKB), known to increase hepatic detoxification enzymes, may also exert anti-inflammatory and anti-cancer activities. We fed male C57BL/6 mice purified AIN93G diets containing no additions, GKB or the GKB-rich fraction of an ethanol extract (GE) from GK to determine if these diets would slow or prevent either inflammation or inflammation-enhanced colon cancer, using the dextran sulfate sodium/azoxymethane mouse model. The GKB (500 μmol/kg diet daily) showed some anti-inflammatory activity, but GE, containing an equal dose of GKB, protected strongly against both inflammation and colon cancer, decreasing adenocarcinomas by 90%. These data support further research into GK as a promising potential anti-cancer agent.
authors.affiliation: Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, United States.
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Butler
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Wallig
authors.forename: Chu Won
authors.initials: CW
authors.lastname: Nho
authors.forename: Cheol-Ho
authors.initials: CH
authors.lastname: Pan
authors.forename: Eun-Ha
authors.initials: EH
authors.lastname: Lee
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Jung
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Jeffery
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D001397:Azoxymethane; D049109:Cell Proliferation; D003092:Colitis / Q000150:complications / Q000517:prevention & control*; D003110:Colonic Neoplasms / Q000150:complications / Q000473:pathology*; D016264:Dextran Sulfate / Q000494:pharmacology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D007150:Immunohistochemistry; D007249:Inflammation / Q000150:complications / Q000517:prevention & control; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology*; D053279:Polyynes / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts; D053279:Polyynes; D016264:Dextran Sulfate; D001397:Azoxymethane