title: [Aplastic anaemia associated with pregnancy].
abstract: Aplastic anaemia is rear disease caused by destruction of pluripotent stem cells in bone marrow. Pregnancy is one of the main factor that lead to immunosuppression. During pregnancy aplastic anaemia could be life-threatening for both mother and child, because of the variety of complications like bleeding and infections. We introduce the first case of pregnant woman with aplastic anaemia in Bulgaria. The woman was diagnosed in 12-13 gestational week. All biometric characteristics of the foetus were normal. The patient was consulted with oncohaematologists, pediatricians, specialists of Obstetrics and Gynaecology, and intensivists. Methylprednisolone, antibiotics, packed cells and platelet transfusions were initiated. However, the moment for interruption of the pregnancy was missed (first trimester). The woman developed a fever and vomited bloody material. Despite the optimal supportive treatment, the patient died. The pathoanatomy diagnose is Aplastic anaemia, induced by the pregnancy. From our experience with that case and other references from the literature we conclude that all pregnant woman with aplastic anaemia should interrupt their pregnancy during first trimester. In those patients who are diagnosed at later terms of pregnancy very supportive infusions and immunosuppressive therapy should be made, including antithymocyte globulin and/or cyclosporine. Women with no improvement from that therapy should achieve a bone-marrow transplantation.
authors.forename: S
authors.initials: S
authors.lastname: Bozhinova
authors.forename: Zl
authors.initials: Z
authors.lastname: Kirovakov
authors.forename: K
authors.initials: K
authors.lastname: Porozhanova
authors.forename: S
authors.initials: S
authors.lastname: Kostova
authors.forename: P
authors.initials: P
authors.lastname: Bozhinov
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000150:complications* / Q000628:therapy*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016913:Blood Component Transfusion; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone