title: Atrial trans-septal thrombus in massive pulmonary embolism salvaged by prolonged extracorporeal life support after thrombo-embolectomy. A bridge to right-sided cardiovascular adaptation.
abstract: Massive pulmonary embolism poses a therapeutic challenge, especially when thrombolytics are controversial. We describe the complicated course of an exceptional case of massive pulmonary embolism exhibiting paradoxic embolization with a thrombus lodged in the foramen ovale. Thrombolysis was considered contraindicated and surgical intervention was performed. Postoperatively, persistent pulmonary hypertension and impending right ventricular (RV) failure necessitated the initiation of extracorporeal life support (ELS), accompanied by therapeutic heparinization, inhaled nitric oxide, levosimendan and sildenafil. On day 8, the patient was successfully weaned from ELS with excellent neurological recovery and virtual normalization of RV pressures and dimensions. (Contra-) indications for thrombolysis and surgical embolectomy are reviewed. The intriguing role of ELS in conjunction with therapeutic heparinization and pharmacological unloading of the right-sided vasculature and the RV is discussed.
authors.forename: Thijs S R
authors.initials: TS
authors.lastname: Delnoij
authors.forename: Ryan E
authors.initials: RE
authors.lastname: Accord
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Weerwind
authors.forename: Dirk W
authors.initials: DW
authors.lastname: Donker
mesh_terms: D003328:Coronary Thrombosis / Q000000981:diagnostic imaging / Q000601:surgery; D017548:Echocardiography, Transesophageal; D004562:Electrocardiography; D017128:Embolectomy; D019320:Embolism, Paradoxical; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000150:complications* / Q000601:surgery*; D017131:Thrombectomy; D014057:Tomography, X-Ray Computed; D018497:Ventricular Dysfunction, Right / Q000150:complications