title: Lucilia sericata chymotrypsin disrupts protein adhesin-mediated staphylococcal biofilm formation.
abstract: Staphylococcus aureus and Staphylococcus epidermidis biofilms cause chronic infections due to their ability to form biofilms. The excretions/secretions of Lucilia sericata larvae (maggots) have effective activity for debridement and disruption of bacterial biofilms. In this paper, we demonstrate how chymotrypsin derived from maggot excretions/secretions disrupts protein-dependent bacterial biofilm formation mechanisms.
authors.affiliation: Medical Microbiology and Infectious Diseases, Institute of Life Science, College of Medicine, Swansea University, Swansea, United Kingdom. l.g.harris@swansea.ac.uk
authors.forename: Llinos G
authors.initials: LG
authors.lastname: Harris
authors.forename: Yamni
authors.initials: Y
authors.lastname: Nigam
authors.forename: James
authors.initials: J
authors.lastname: Sawyer
authors.forename: Dietrich
authors.initials: D
authors.lastname: Mack
authors.forename: David I
authors.initials: DI
authors.lastname: Pritchard
mesh_terms: D018829:Adhesins, Bacterial / Q000378:metabolism*; D000818:Animals; D018441:Biofilms / Q000187:drug effects*; D002918:Chymotrypsin / Q000378:metabolism*; D004175:Diptera / Q000201:enzymology*; D007814:Larva / Q000201:enzymology; D013211:Staphylococcus aureus / Q000502:physiology*; D013212:Staphylococcus epidermidis / Q000502:physiology*
chemical_list: D018829:Adhesins, Bacterial; D002918:Chymotrypsin