title: Dome-type: a distinctive variant of colonic adenocarcinoma.
abstract: Introduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features. Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old man. Histopathological examination showed a cancerized adenoma invading the submucosa with several typical features of dome-type adenocarcinoma, in particular the associated prominent lymphoid tissue. Immunohistochemistry showed retention of the mismatch repair proteins MLH-1, MSH-2, MLH-6, and PMS-2. Conclusion. We report an additional case of dome-type adenocarcinoma of the colon as an early, low-risk, and microsatellite stable tumor, indicating that this particular histotype may deserve specific consideration for both classification and management.
authors.affiliation: Service de Pathologie Clinique, Hôpitaux Universitaires de Genève, 1211 Geneva, Switzerland.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Puppa
authors.forename: Mariella
authors.initials: M
authors.lastname: Molaro