title: N-cyano sulfoximines: COX inhibition, anticancer activity, cellular toxicity, and mutagenicity.
abstract: From insects to cancer: N-Cyano sulfoximines were evaluated for COX inhibition and antiproliferative activity against a panel of cancer cell lines. The most active compound exhibited potent COX-2 inhibition, some selectivity for COX-2 over COX-1, only slight cytotoxicity towards healthy cells (HaCaT skin cells), and no mutagenic potential (as determined by an Ames assay).
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52056 Aachen, Germany.
authors.forename: Seong Jun
authors.initials: SJ
authors.lastname: Park
authors.forename: Hannah
authors.initials: H
authors.lastname: Baars
authors.forename: Stefanie
authors.initials: S
authors.lastname: Mersmann
authors.forename: Helmut
authors.initials: H
authors.lastname: Buschmann
authors.forename: Jens Malte
authors.initials: JM
authors.lastname: Baron
authors.forename: Philipp M
authors.initials: PM
authors.lastname: Amann
authors.forename: Katharina
authors.initials: K
authors.lastname: Czaja
authors.forename: Henner
authors.initials: H
authors.lastname: Hollert
authors.forename: Kerstin
authors.initials: K
authors.lastname: Bluhm
authors.forename: Regine
authors.initials: R
authors.lastname: Redelstein
authors.forename: Carsten
authors.initials: C
authors.lastname: Bolm
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007313:Insecta; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D009570:Nitriles / Q000737:chemistry* / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013457:Sulfur Compounds / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D016861:Cyclooxygenase Inhibitors; D009570:Nitriles; D013457:Sulfur Compounds; D011451:Prostaglandin-Endoperoxide Synthases