title: Performance of HbA1c and fasting plasma glucose in screening for diabetes in patients undergoing coronary angiography.
abstract: OBJECTIVE
  The performance of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) was compared in screening for diabetes by an oral glucose tolerance test (OGTT) in patients undergoing coronary angiography (CAG).
  
  
  METHODS
  Patients without known diabetes admitted for CAG were eligible. OGTT and HbA1c were assessed 2-4 weeks after hospital discharge. The performance of HbA1c and FPG was evaluated by using receiver operating characteristic (ROC) analysis.
  
  
  RESULTS
  Diabetes was diagnosed in 83 of 400 patients (20.8%). The area under the ROC curve was higher for FPG than for HbA1c (0.81 vs. 0.73, P = 0.032). We proposed a screening algorithm and validated it in another 170 patients. Overall, this algorithm reduced the number of OGTTs by 71.4% (sensitivity 74.4%, specificity 100%).
  
  
  CONCLUSIONS
  FPG performed better than HbA1c in screening for diabetes in patients undergoing CAG. A screening algorithm might help to reduce the number of OGTTs.
authors.affiliation: Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Jun-Sing
authors.initials: JS
authors.lastname: Wang
authors.forename: I-Te
authors.initials: IT
authors.lastname: Lee
authors.forename: Wen-Jane
authors.initials: WJ
authors.lastname: Lee
authors.forename: Shih-Yi
authors.initials: SY
authors.lastname: Lin
authors.forename: Chia-Po
authors.initials: CP
authors.lastname: Fu
authors.forename: Chih-Tai
authors.initials: CT
authors.lastname: Ting
authors.forename: Wen-Lieng
authors.initials: WL
authors.lastname: Lee
authors.forename: Kae-Woei
authors.initials: KW
authors.lastname: Liang
authors.forename: Wayne Huey-Herng
authors.initials: WH
authors.lastname: Sheu
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D017023:Coronary Angiography; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis* / Q000378:metabolism; D005215:Fasting / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin