title: Association of maximum weight with hyperuricemia risk: a retrospective study of 21,414 Chinese people.
abstract: BACKGROUND
  Obesity has been demonstrated to be associated with increased serum uric acid (SUA); however, little is known regarding the relationship between maximum weight, or maximum weight fluctuation, and uric acid concentration. Through retrospective means, we determined the association of maximum weight with SUA risk.
  
  
  METHODS
  Data of 21,414 participants (8,630 males and 12,784 females) from the 2007-8 China National Diabetes and Metabolic Disorders Study were analyzed for parameters including lifestyle habits, biochemical blood analysis and self-reported maximum weight.
  
  
  RESULTS
  Elevated SUA subjects shared a cluster of demographic features. After adjustment for age, gender, education, smoking, drinking, physical activity, WHR, height, eGFR(evaluate glomerular filtration rate), and diuretic usage, multivariate logistic regression models demonstrated maximum weight was associated with increased risk of elevated SUA level (P<0.001). Duration of maximum weight was related with decreased risk of elevated SUA level (P<0.001). There was a significant correlation between time of weight loss and risk of increased SUA level reduction (P<0.001). Furthermore, our data indicated that the degree of weight loss from maximum weight was another important factor for the risk of increased SUA level reduction (P<0.001). Finally, ROC curve analysis revealed area under the curve was 0.661 (95% CI, 0.647-0.674), statistically significant for maximum weight association with hyperuricemia (P<0.001).
  
  
  CONCLUSIONS
  Maximum weight is a strong risk factor for increased uric acid level in the Chinese population, which might serve as a novel clinical indicator suggesting hyperuricemia. Controlling maximum weight, keeping weight to the appropriate range, and maintaining the stable weight may be conducive for decreasing risk of hyperuricemia.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of the Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Gao
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Jiapu
authors.initials: J
authors.lastname: Ge
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Wayne B
authors.initials: WB
authors.lastname: Lau
authors.forename: Yi
authors.initials: Y
authors.lastname: Wan
authors.forename: Nanyan
authors.initials: N
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Xing
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Jianfang
authors.initials: J
authors.lastname: Fu
authors.forename: Xiaomiao
authors.initials: X
authors.lastname: Li
authors.forename: Hongxia
authors.initials: H
authors.lastname: Jia
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Qiuhe
authors.initials: Q
authors.lastname: Ji
mesh_terms: D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data*; D001835:Body Weight; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid