title: Antimicrobial N-halamine modified chitosan films.
abstract: The inherent antimicrobial properties and biodegradability of chitosan make it an ideal candidate for antimicrobial materials. In this study, N-halamine precursor 3-glycidyl-5,5-dimethylhydantoin (GH) was synthesized and bonded onto chitosan by a ring opening reaction between chitosan and GH. The chitosan film modified with the N-halamine precursor could be rendered biocidal after exposure to a dilute household bleach solution. Syntheses routes, characterization data, and antimicrobial test results are presented. The chlorinated films with 2.60 × 10(18) atoms/cm(2) of active chlorine were challenged with Staphylococcus aureus (ATCC 6538) and Escherichia coli O157:H7 (ATCC 43895) and showed good efficacy against these two bacterial species with log reductions of 7.4 and 7.5 within 10 and 5 min of contact time, respectively. These films may serve as potential materials for food packaging and biomedical applications.
authors.affiliation: Key Laboratory of Eco-textiles of Ministry of Education, College of Textiles and Clothing, Jiangnan University, Wuxi, Jiangsu 214122, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.forename: Pei
authors.initials: P
authors.lastname: Hu
authors.forename: Xuehong
authors.initials: X
authors.lastname: Ren
authors.forename: S D
authors.initials: SD
authors.lastname: Worley
authors.forename: T S
authors.initials: TS
authors.lastname: Huang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible; D019453:Escherichia coli O157 / Q000187:drug effects; D006827:Hydantoins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D006827:Hydantoins; D011108:Polymers; C030615:5,5-dimethylhydantoin; D048271:Chitosan