title: [New class III antiarrhythmic drugs for treatment of atrial fibrillation].
abstract: Last two decades have been dedicated to intensive search for new class III antiarrhythmic drugs, especially for atrial fibrillation. Here we present a review of the status this problem. Influence on transmembranous ion currents and mechanisms of antiarrhythmic action are described. Results of experimental and clinical studies are reviewed. Possible perspectives of newest atrial-selective medications are discussed. Russia's class III antiarrhythmic drugs are of special interest of the article. First data on efficacy and safety of newest agent niferidil are presented. This drug undergoes clinical testing at present time.
authors.forename: E B
authors.initials: EB
authors.lastname: Maĭkov
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000145:classification / Q000494:pharmacology; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D001682:Biological Availability; D002986:Clinical Trials as Topic; D015507:Drugs, Investigational / Q000494:pharmacology*; D022062:Electrophysiologic Techniques, Cardiac / Q000379:methods / Q000639:trends; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects
chemical_list: D000889:Anti-Arrhythmia Agents; D015507:Drugs, Investigational; D007473:Ion Channels