title: Hypervalent iodine mediated para-selective fluorination of anilides.
abstract: A metal-free method for the direct regioselective fluorination of anilides has been developed. In the presence of bis(tert-butylcarbonyloxy)iodobenzene (PhI(OPiv)(2)) and hydrogen fluoride-pyridine, the para-fluorination products of anilides were obtained in moderate to good yields. Because of its operational safety and the use of readily available reagents, this new procedure provides facile access to a variety of para-fluorinated anilides.
authors.affiliation: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China.
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.forename: Wen-He
authors.initials: WH
authors.lastname: Zhong
authors.forename: Shuai
authors.initials: S
authors.lastname: Meng
authors.forename: Xiang-Bao
authors.initials: XB
authors.lastname: Meng
authors.forename: Zhong-Jun
authors.initials: ZJ
authors.lastname: Li
mesh_terms: D000813:Anilides / Q000737:chemistry*; D054879:Halogenation; D006858:Hydrofluoric Acid / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D007462:Iodobenzenes / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000813:Anilides; D007462:Iodobenzenes; D011725:Pyridines; D007455:Iodine; C031905:iodobenzene; C023666:pyridine; D006858:Hydrofluoric Acid