title: Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields.
abstract: The efficacy of nanoparticle-mediated drug delivery is limited by its peri-vascular sequestration, thus necessitating a strategy to trigger drug release from such intra-tumoral nanocarrier-drug depots. In our efforts to explore remotely-activated nanocarriers, we have developed carbon nanocapsules comprised of an ultra-short carbon nanotube shell (US-tubes) loaded with cisplatin (CDDP@US-tubes) and covered with a Pluronic surfactant wrapping to minimize passive release. We demonstrate here that non-invasive radiofrequency (RF) field activation of the CDDP@US-tubes produces heat that causes Pluronic disruption which triggers cisplatin release in an RF-dependent manner. Furthermore, release-dependent cytotoxicity is demonstrated in human hepatocellular carcinoma cell lines.
authors.affiliation: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230-1402, USA. mraoof@mdanderson.org
authors.forename: Mustafa
authors.initials: M
authors.lastname: Raoof
authors.forename: Brandon T
authors.initials: BT
authors.lastname: Cisneros
authors.forename: Adem
authors.initials: A
authors.lastname: Guven
authors.forename: Sophia
authors.initials: S
authors.lastname: Phounsavath
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Corr
authors.forename: Lon J
authors.initials: LJ
authors.lastname: Wilson
authors.forename: Steven A
authors.initials: SA
authors.lastname: Curley
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002244:Carbon; D002945:Cisplatin / Q000008:administration & dosage*; D006801:Humans; D053769:Nanocapsules; D011846:Radio Waves
chemical_list: D000970:Antineoplastic Agents; D053769:Nanocapsules; D002244:Carbon; D002945:Cisplatin