title: Urease operon and urease activity in commensal and disease-causing nontypeable Haemophilus influenzae.
abstract: The ure operon was significantly more prevalent in Haemophilus influenzae isolates causing otitis media and chronic obstructive pulmonary disease (COPD)-associated bronchitis than in those from throats of healthy individuals (97% versus 78.1%, P < 0.001). Strains lacking the ure operon are over 8 times more likely to be from the throat than either otitis media or COPD isolates.
authors.affiliation: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA. lxzhang@umich.edu
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhang
authors.forename: Mayuri
authors.initials: M
authors.lastname: Patel
authors.forename: Jingping
authors.initials: J
authors.lastname: Xie
authors.forename: Gregg S
authors.initials: GS
authors.lastname: Davis
authors.forename: Carl F
authors.initials: CF
authors.lastname: Marrs
authors.forename: Janet R
authors.initials: JR
authors.lastname: Gilsdorf
mesh_terms: D001991:Bronchitis / Q000382:microbiology; D004789:Enzyme Activation; D005798:Genes, Bacterial; D006192:Haemophilus Infections / Q000382:microbiology; D006193:Haemophilus influenzae / Q000201:enzymology* / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D009876:Operon; D010033:Otitis Media / Q000382:microbiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000382:microbiology; D014510:Urease / Q000235:genetics* / Q000378:metabolism*; D037521:Virulence Factors / Q000235:genetics
chemical_list: D037521:Virulence Factors; D014510:Urease