title: Increased concentration of metronidazole and its hydroxy metabolite in colon cancer in women.
abstract: BACKGROUND
  Metronidazole (MTZ) is indicated in the prevention of infections during surgical procedures. However, some data have shown that metronidazole has carcinogenic potential.
  
  
  METHODS
  In the present work, we determined concentrations of metronidazole and its hydroxy metabolite (MTZOH) in colorectal cancer patients. MTZ and MTZOH were measured in tumor tissue and surrounding healthy tissue by LC-ESI-MS-MS method.
  
  
  RESULTS
  We found different concentration of MTZ and MTZOH in colorectal cancer and healthy tissue. Interestingly, we noted a higher level of the above substances in women vs. men, both in healthy and cancerous gut.
  
  
  CONCLUSIONS
  We suggest that women are more exposed to a potential carcinogenic effect of metronidazole than men.
authors.affiliation: Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, PL 15-295 Białystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Sadowska
authors.forename: Bogusław
authors.initials: B
authors.lastname: Kędra
authors.forename: Dariusz
authors.initials: D
authors.lastname: Cepowicz
authors.forename: Lech
authors.initials: L
authors.lastname: Rodziewicz
authors.forename: Anna
authors.initials: A
authors.lastname: Fiedorowicz
authors.forename: Sławomir
authors.initials: S
authors.lastname: Prokopiuk
authors.forename: Wojciech
authors.initials: W
authors.lastname: Miltyk
authors.forename: Halina
authors.initials: H
authors.lastname: Car
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000378:metabolism*; D003106:Colon / Q000378:metabolism; D003110:Colonic Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D008795:Metronidazole / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole