title: [Inhibitory effect of propentofylline on chronic prostatitis pain in rats and its mechanism].
abstract: OBJECTIVE
  To investigate the effects of propentofylline on the expressions of glial fibrillary acidic protein (GFAP) and TNF-alpha and its action mechanism in the rat model of chronic prostatitis pain (CPP).
  
  
  METHODS
  We equally randomized 30 male SD rats to groups A (sham operation), B (CPP model) and C (propentofylline intervention). After modelling, the rats in group C received intraperitoneal injection of propentofylline at 2 mg/kg, while those in groups A and B were injected intrathecally with the same dose of normal saline. At 15 days after the treatment, we examined the expressions of GFAP in the spinal cord and TNF-alpha in the prostate by immunohistochemistry.
  
  
  RESULTS
  The levels of GFAP and TNF-alpha were obviously lower in group A (2.56 +/- 0.16 and 1.34 +/- 0.05) than in B (16.79 +/- 0.72 and 3.46 +/- 0.05) and C (8.83 +/- 0.63 and 2.25 +/- 0.05), significantly increased in B as compared with A (P < 0.05). And the increase was markedly less in group C than in B (P < 0.05).
  
  
  CONCLUSIONS
  Propentofylline inhibits chronic prostatitis pain in the rat model by suppressing the activation of astroglia and the release of inflammatory mediators.
authors.affiliation: Department of Urology, The First Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi 030001, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Chun
authors.initials: C
authors.lastname: Liu
authors.forename: Yun-Tong
authors.initials: YT
authors.lastname: Guo
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D002908:Chronic Disease; D059350:Chronic Pain / Q000188:drug therapy / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D008297:Male; D011472:Prostatitis / Q000188:drug therapy / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014970:Xanthines / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D005904:Glial Fibrillary Acidic Protein; D014409:Tumor Necrosis Factor-alpha; D014970:Xanthines; C032114:propentofylline