title: Pseudothrombocytopenia in a neonate due to mother?
abstract: Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a false low platelet count reported by an automated haematology analyzer due to in vitro aggregation of platelets. This aggregation is due to the interaction between antibodies and EDTA-dependent crypt antigens on platelets. We observed a new born child whose mother was diagnosed with transient PTCP due to transplacental transmission of maternal immunoglobulin G antibodies during pregnancy.
  
  
  CONCLUSIONS
  Although maternal-neonatal PTCP is rare, it is important to consider this phenomenon as a cause of trombocytopenia, as it can result in unnecessary diagnostic workup and treatment.
authors.affiliation: Department of Paediatrics, Medical Center Alkmaar, Alkmaar, Netherlands. judithkorterink@hotmail.com
authors.forename: J J
authors.initials: JJ
authors.lastname: Korterink
authors.forename: B
authors.initials: B
authors.lastname: Boersma
authors.forename: M
authors.initials: M
authors.lastname: Schoorl
authors.forename: L
authors.initials: L
authors.lastname: Porcelijn
authors.forename: P C M
authors.initials: PC
authors.lastname: Bartels
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D001792:Blood Platelets / Q000276:immunology*; D004492:Edetic Acid / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D011247:Pregnancy; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000925:Anticoagulants; D007074:Immunoglobulin G; D004492:Edetic Acid