title: [Epidemiological overview of antibiotic resistance in France and worldwide].
abstract: Antibiotic resistance appeared early after the introduction of these molecules in therapeutic. But, this resistance has long been confined to care facilities. Twenty years ago, resistance emerged in community with the methicillin resistance in Staphylococcus aureus and also with the reduced susceptibility to penicillin in pneumococci, which are good examples. Fortunately, for these two species, in France, the situation appears to be controlled. The most worrying now is the emergence of resistance to major antimicrobial agents in Escherichia coli both in community and in hospitals. The third-generation cephalosporins and the fluoroquinolones are concerned. This situation is currently not well controlled here and worldwide. The only recourse remaining carbapenems, antibiotics reserved for hospital use. Unfortunately, new mechanisms of resistance to these molecules are emerging.
authors.affiliation: Service de Bactériologie hygiène, hôpital Tenon, póle biologie médicale et pathologie, hôpitaux universitaires Est Parisien, AP-HP, département de Bactériologie, faculté de médecine Pierre-et-Marie-Curie, université Pierre-et-Marie-Curie-Paris-6, 75970 Paris Cedex, France. guillaume.arlet@tnn.aphp.fr
authors.forename: Guillaume
authors.initials: G
authors.lastname: Arlet
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy; D024881:Drug Resistance, Bacterial; D062665:Epidemiological Monitoring; D014943:Global Health; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents