title: c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1α.
abstract: Angiogenesis plays a pivotal role in tumor growth. The hypoxia-inducible factor 1, α subunit (HIF-1α)/vascular endothelial growth factor pathway is the most important pathway for regulating angiogenesis in the tumor microenvironment. c-Myc is an important oncogene that has many biological functions. In this study, we investigated the role of c-Myc in tumor angiogenesis. We found that the overexpression of c-Myc in colon cancer cells could promote the expression of HIF-1α and that of vascular endothelial growth factor. Moreover, we found that c-Myc regulated HIF-1α at the post-transcriptional level. The results revealed c-Myc-dependent regulation of HIF-1α instead of HIF-1α-dependent c-Myc regulation for the first time. They also showed that c-Myc was essential to regulate colon cancer cell-mediated angiogenesis and contributed to tumor growth. This research provides the theoretical basis for clinical trials of new therapeutic targets of c-Myc and HIF-1α in colon cancer cells.
authors.affiliation: Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Shaoxin
authors.initials: S
authors.lastname: Cai
authors.forename: Guihua
authors.initials: G
authors.lastname: Wang
authors.forename: Xiaonian
authors.initials: X
authors.lastname: Cao
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.forename: Xuelai
authors.initials: X
authors.lastname: Luo
authors.forename: Yongdong
authors.initials: Y
authors.lastname: Feng
authors.forename: Junbo
authors.initials: J
authors.lastname: Hu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D003110:Colonic Neoplasms / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000096:biosynthesis*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
chemical_list: D051793:Hypoxia-Inducible Factor 1; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A