title: Changes in circulating adiponectin and metabolic hormone concentrations during periparturient and lactation periods in Holstein dairy cows.
abstract: Although our previous report demonstrated that adiponectin and AdipoR1 gene expressions changed among different lactation stages in the bovine mammary gland, its in vivo kinetics remain unclear in ruminant animals. In this study, we investigated the changes in circulating concentrations of adiponectin, as well as other metabolic hormones and metabolites, (i) during the periparturient period and (ii) among different lactation stages, in Holstein dairy cows. In experiment 1, serum adiponectin concentrations increased after parturition. Serum insulin concentrations were lower in the postpartum than prepartum period, whereas serum growth hormone (GH) concentrations increased in the postpartum period. Serum nonesterified fatty acids (NEFA) levels were increased during the postpartum period and were dependent on the parity. In experiment 2, there was no significant difference in plasma adiponectin concentrations among lactational stages. Plasma insulin concentrations tended to be lower in early lactation while plasma GH levels tended to be higher. Plasma NEFA concentrations were significantly lower in mid- and late-lactation stages than non-lactation stages. These findings indicate that elevation of serum adiponectin might be involved in energy metabolism just around parturition, and might exert its action through regulation of receptor expression levels in target tissues in each lactational stage in Holstein dairy cows.
authors.affiliation: Laboratory of Animal Physiology, Graduate School of Agricultural Science, Tohoku University, Aoba, Sendai, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Ohtani
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Sato
authors.forename: Astrid
authors.initials: A
authors.lastname: Ardiyanti
authors.forename: Sang-Houn
authors.initials: SH
authors.lastname: Song
authors.forename: Reiichiro
authors.initials: R
authors.lastname: Sato
authors.forename: Ken
authors.initials: K
authors.lastname: Onda
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Wada
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Obara
authors.forename: Keiichi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hagino
authors.forename: Sang-Gun
authors.initials: SG
authors.lastname: Roh
authors.forename: Kazuo
authors.initials: K
authors.lastname: Katoh
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000818:Animals; D002417:Cattle / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood; D007328:Insulin / Q000097:blood; D007774:Lactation / Q000097:blood / Q000502:physiology*; D036801:Parturition / Q000097:blood / Q000502:physiology*
chemical_list: D052242:Adiponectin; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D013006:Growth Hormone