title: Power of biomarkers and their relative contributions to metabolic syndrome in Slovak adult women.
abstract: BACKGROUND
  Metabolic syndrome (MetS) comprises a cluster of risk components which pre-dispose individuals to cardiovascular mortality.
  
  
  OBJECTIVE
  The purpose of this study is to investigate the variability of biochemical and anthropometric characteristics, apolipoprotein E (APOE) and angiotensin converting enzyme (ACE) genes and their contribution to MetS manifestation.
  
  
  METHODS
  A total of 438 adult women were recruited from different localities in Slovakia. All data was established by standard anthropometric, biochemical and genetic methods.
  
  
  RESULTS
  The logarithm of the ratio of plasma concentration of triglycerides to HDL-cholesterol [log(TG-to-HDL-C)], waist circumference, systolic blood pressure, apolipoprotein A1, glucose and alanin aminotransferase accounted for most of the differences in MetS manifestation. Logistic regression showed that participants with risk values of the atherogenic index log(TG-to-HDL-C) had a 15.62-fold higher risk of MetS compared to those with lower values for this index (95% CI = 8.3-29.1). Women with hyperglycaemia (or formerly diagnosed diabetes mellitus) had an 8.82-times higher risk of MetS (95%CI = 3.22-24.16). Women with hyper-uricaemia had the same risk of MetS incidence as women with abdominal obesity, Exp (B) = 4.05.Hypercholesterolaemia, ACE and APOE genotypes did not influence MetS.
  
  
  CONCLUSIONS
  MetS may involve many risk factors that can cause serious disorders in multiple organs. However, women with risk values involving plasma atherogenic index log (TG-to-HDL-C) experienced the highest risk of developing MetS.
authors.affiliation: Department of Anthropology, Faculty of Natural Sciences, Comenius University, 842 15 Bratislava, Slovakia. luptakova@fns.uniba.sk
authors.forename: Lenka
authors.initials: L
authors.lastname: Luptáková
authors.forename: Daniela
authors.initials: D
authors.lastname: Siváková
authors.forename: Marta
authors.initials: M
authors.lastname: Cvíčelová
authors.forename: Ladislava
authors.initials: L
authors.lastname: Wsólová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Danková
authors.forename: Alexandra
authors.initials: A
authors.lastname: Michnová
authors.forename: Pavel
authors.initials: P
authors.lastname: Blažíček
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001774:Blood Chemical Analysis; D015992:Body Mass Index; D005260:Female; D006801:Humans; D006973:Hypertension; D015994:Incidence; D008099:Liver / Q000201:enzymology; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology*; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics; D015995:Prevalence; D012307:Risk Factors; D018154:Slovakia / Q000453:epidemiology; D049629:Waist-Hip Ratio
chemical_list: D001057:Apolipoproteins E; D015415:Biomarkers; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A