title: Surgical removal of endometrioma decreases the NF-kB1 (p50/105) and NF-kB p65 (Rel A) expression in the eutopic endometrium during the implantation window.
abstract: We aimed to investigate whether the surgical removal of endometrioma alters the nuclear factor-kappa B1 (NF-kB1; p50/105) and NF-kB p65 (Rel A) expression in the eutopic endometrium of infertile women with endometrioma before and after laparoscopic removal of the ovarian endometrioma during the mid-secretory phase. Infertile women with endometrioma (n = 15) were enrolled. Infertile patients with nonendometriotic ovarian cyst (n = 10) and healthy fertile women (n = 10) were recruited as controls. Endometrial samples were obtained before and 3 months after the laparoscopic cystectomy. The NF-kB1 (p50/105) levels were analyzed by enzyme-linked immunosorbent assay (ELISA) in the endometrium of all groups before and after laparoscopic ovarian cystectomy during implantation window. Expression of NF-kB1 (p50/105) in eutopic endometrium was significantly higher in infertile women with endometrioma compared to nonendometriotic cyst and fertile controls (P < .05). Laparoscopic cystectomy resulted in a significant decrease in NF-kB1 expression in women with endometrioma. The NF-kB p65 (Rel A) immunoreactivity of eutopic endometrium decreased significantly subsequent to the surgical removal of the endometrioma. In conclusion, increased endometrial NF-kB expression may contribute to endometriosis-associated infertility.
authors.affiliation: Department of Obstetric and Gynecology, Inonu University, School of Medicine, Malatya, Turkey.
authors.forename: Onder
authors.initials: O
authors.lastname: Celik
authors.forename: Ebru
authors.initials: E
authors.lastname: Celik
authors.forename: Ilgin
authors.initials: I
authors.lastname: Turkcuoglu
authors.forename: Ercan
authors.initials: E
authors.lastname: Yilmaz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ulas
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Simsek
authors.forename: Abdullah
authors.initials: A
authors.lastname: Karaer
authors.forename: Nilufer
authors.initials: N
authors.lastname: Celik
authors.forename: Nasuhi Engin
authors.initials: NE
authors.lastname: Aydin
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozerol
authors.forename: Cihat
authors.initials: C
authors.lastname: Unlu
mesh_terms: D000328:Adult; D010064:Embryo Implantation / Q000502:physiology*; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery; D052002:NF-kappa B p50 Subunit / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D013997:Time Factors; D051996:Transcription Factor RelA / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D052002:NF-kappa B p50 Subunit; D051996:Transcription Factor RelA