title: New amide alkaloids from Piper longum.
abstract: Bioassay-guided phytochemical investigation on Piper longum resulted in the isolation of two new compounds. By analyses of the MS, IR, UV, 1D and 2D NMR data, the two new compounds were identified as 3β, 4α-dihydroxy-1-(3-phenylpropanoyl)-piperidine-2-one (1) and (2E, 4E, 14Z)-6-hydroxyl-N-isobutyleicosa-2,4,14-trienamide (2). In vitro anti-HBV bioassay demonstrated compound 1 possessed remarkable activity suppressing the secretion of HBeAg in Hep G2.2.15 cell line, with an IC(50) value of 0.21mM and SI value of 16.4.
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650500, China. jiangzy2010@163.com
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Jiang
authors.forename: Wen-Feng
authors.initials: WF
authors.lastname: Liu
authors.forename: Chao-Guan
authors.initials: CG
authors.lastname: Huang
authors.forename: Xiang-Zhong
authors.initials: XZ
authors.lastname: Huang
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry*; D001681:Biological Assay; D002460:Cell Line; D005638:Fruit / Q000737:chemistry; D006515:Hepatitis B virus / Q000187:drug effects / Q000502:physiology; D022781:Hepatocytes / Q000187:drug effects / Q000821:virology; D006801:Humans; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D010881:Piperidones / Q000737:chemistry*
chemical_list: C582258:(2E,4E,14Z)-6-hydroxyl-N-isobutyleicosa-2,4,14-trienamide; C582257:3beta,4alpha-dihydroxy-1-(3-phenylpropanoyl)-piperidine-2-one; D000470:Alkaloids; D000577:Amides; D000998:Antiviral Agents; D010881:Piperidones