title: Effect of viologen-phosphorus dendrimers on acetylcholinesterase and butyrylcholinesterase activities.
abstract: The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is the first step in checking whether new compounds can be considered as drugs for treating neurodegenerative diseases. The effect of viologen-phosphorus dendrimers on AChE and BChE activities was studied. The results show that the effects on the cholinesterase activities depend on dendrimer type and size. Viologen dendrimers can interact with the enzymes in two ways: they can bind either to a peripheral site of the enzyme or to amino acids located near the active site, inhibiting catalysis by both cholinesterases. All tested non-toxic viologen-phosphorus dendrimers inhibited the activities of both cholinesterases, showing their potential as new drugs for treating neurodegenerative diseases.
authors.affiliation: Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska St., 90-236 Lodz, Poland. ciepluch@biol.uni.lodz.pl
authors.forename: Karol
authors.initials: K
authors.lastname: Ciepluch
authors.forename: Monika
authors.initials: M
authors.lastname: Weber
authors.forename: Nadia
authors.initials: N
authors.lastname: Katir
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Caminade
authors.forename: Abdelkrim
authors.initials: A
authors.lastname: El Kadib
authors.forename: Barbara
authors.initials: B
authors.lastname: Klajnert
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Majoral
authors.forename: Maria
authors.initials: M
authors.lastname: Bryszewska
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D002091:Butyrylcholinesterase / Q000378:metabolism*; D002942:Circular Dichroism; D050091:Dendrimers / Q000737:chemistry / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000201:enzymology; D005453:Fluorescence; D006801:Humans; D010758:Phosphorus / Q000737:chemistry / Q000494:pharmacology*; D055672:Static Electricity; D014755:Viologens / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D050091:Dendrimers; D014755:Viologens; D010758:Phosphorus; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase