title: [Study on pharmacokinetics of ginkgolide B injection in Beagle dogs].
abstract: OBJECTIVE
  To study the pharmacokinetics of ginkgolide B injection in Beagle dogs.
  
  
  METHODS
  Determined the serum concentration of ginkgolide B by LC-MS and calculated its parameter of pharmacokinetics via DAS 2.0 software.
  
  
  RESULTS
  After intravenous drips of 0.62, 2.07 and 10.35 mg/kg ginkgolide B, parameters of pharmacokinetics of ginkgolide B were as follows: Tmax were 0.444, 1, 1 h; Cmax were 0.764, 3.024, 11.013 mg/L; AUC(0-1) were 1.007, 3.644, 16.646 mg x h/Lo.
  
  
  CONCLUSIONS
  Ginkgolide B has two compartment model in Beagle dogs.
authors.affiliation: Guangdong Research Institute of Traditional Chinese Medicine, Guangzhou 510520, China. zxtcpu@yahoo.com.cn
authors.forename: Xian-tao
authors.initials: XT
authors.lastname: Zhang
authors.forename: Hao-yan
authors.initials: HY
authors.lastname: Jiao
authors.forename: Qi-liang
authors.initials: QL
authors.lastname: Suo
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D020441:Ginkgo biloba / Q000737:chemistry*; D046934:Ginkgolides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D007783:Lactones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D023421:Models, Animal; D010972:Platelet Activating Factor / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000493:pharmacokinetics*; D011897:Random Allocation; D013997:Time Factors
chemical_list: D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; C045856:ginkgolide B