title: Circulating fibroblast growth factors as metabolic regulators--a critical appraisal.
abstract: The circulating FGFs are a new group of proteins believed to function as classic hormones. With emphasis on human metabolism, we critically review current data, and propose that--although a number of questions remain--circulating FGF23 is pivotal in the control of phosphate and vitamin D metabolism, and may have additional systemic effects, particularly in chronic kidney disease; that FGF19 signaling is important for the regulation of bile acid metabolism, whereas its physiological role in promoting glucose and lipid metabolism is less well understood; and that the physiological role of circulating FGF21 in metabolic homeostasis warrants further investigation.
authors.affiliation: Metabolism Unit, Center for Endocrinology, Metabolism, and Diabetes, Department of Medicine, and Molecular Nutrition Unit, Center for Biosciences NOVUM, Karolinska Institute at Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden. bo.angelin@ki.se
authors.forename: Bo
authors.initials: B
authors.lastname: Angelin
authors.forename: Tobias E
authors.initials: TE
authors.lastname: Larsson
authors.forename: Mats
authors.initials: M
authors.lastname: Rudling
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology; D008659:Metabolic Diseases / Q000378:metabolism / Q000473:pathology; D010710:Phosphates / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000378:metabolism / Q000473:pathology; D014807:Vitamin D / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; C117476:FGF19 protein, human; C000717427:FGF23 protein, human; D010710:Phosphates; C414620:fibroblast growth factor 21; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23