title: Santonin-related compound 2 inhibits the nuclear translocation of NF-κB subunit p65 by targeting cysteine 38 in TNF-α-induced NF-κB signaling pathway.
abstract: (11S)-2α-Bromo-3-oxoeudesmano-12,6α-lactone, designated santonin-related compound 2 (SRC2), only weakly affected IκBα degradation after tumor necrosis factor-α (TNF-α) stimulation, but strongly blocked the nuclear translocation of nuclear factor κB (NF-κB) subunit p65. Replacement of Cys-38 of p65 with serine abolished the inhibitory effect of SRC2 on this TNF-α-induced nuclear translocation. These results indicate that SRC2 inhibits the nuclear translocation of p65 by targeting Cys-38.
authors.affiliation: Department of Applied Biology, Kyoto Institute of Technology, Kyoto, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Tamura
authors.forename: Kyoko
authors.initials: K
authors.lastname: Morimoto
authors.forename: Seiya
authors.initials: S
authors.lastname: Hirano
authors.forename: Liyan
authors.initials: L
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ando
authors.forename: Takao
authors.initials: T
authors.lastname: Kataoka
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000187:drug effects; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000187:drug effects* / Q000378:metabolism*; D003545:Cysteine; D006801:Humans; D012500:Santonin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*; D051996:Transcription Factor RelA / Q000737:chemistry / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
chemical_list: D051996:Transcription Factor RelA; D014409:Tumor Necrosis Factor-alpha; C581415:santonin-related compound 2; D012500:Santonin; D003545:Cysteine