title: The role of oxidative stress and inflammation in the early evaluation of acute non-ST-elevation myocardial infarction: an observational study.
abstract: OBJECTIVE
  We aimed to assess the role of oxidative stress (OS) and inflammation in the early evaluation of initial acute non -ST -elevation myocardial infarction (NSTEMI) compared with unstable angina pectoris (USAP).
  
  
  METHODS
  Forty-seven (54%) patients with NSTEMI and 40 (46%) with (USAP) were included in this cross-section observational study. We assessed the oxidative stress and inflammation parameters. Statistical analysis was performed using Fisher's exact test, Chi-square test, Mann-Whitney U test, Student's t-test, and Pearson correlation analysis for assess the correlations between variables.
  
  
  RESULTS
  Plasma total oxidative stress (TOS) and OS index levels were significantly higher (p<0.001 for both comparisons), in patients with NSTEMI. In addition, white blood cell count (WBC) and high-sensitive C-reactive protein (hs-CRP) levels were significantly higher in patients with NSTEMI (respectively; p<0.001, p=0.02). Age, WBC and low- density lipoprotein cholesterol showed positive correlations with TOS level (Pearson correlation coefficient: r=0.290, p=0.006; r=0.431, p<0.001; r=0.219, p=0.042 respectively), and also age showed positive correlation with OS index (Pearson correlation coefficient; r=0.246; p=0.021). However, the values of the troponin I and creatine kinase-MB fraction did not differ between the two groups (p>0.05 for all).
  
  
  CONCLUSIONS
  TOS, OSI, WBC and CRP levels are significantly higher in NSTEMI subject. These data suggest that inflammatory processes and oxidative stress together play a role in the pathogenesis of acute NSTEMI.
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Harran University, Şanlıurfa-Turkey. tahirgokdemir@mynet.com
authors.forename: Mehmet Tahir
authors.initials: MT
authors.lastname: Gökdemir
authors.forename: Halil
authors.initials: H
authors.lastname: Kaya
authors.forename: Ozgür
authors.initials: O
authors.lastname: Söğüt
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Kaya
authors.forename: Levent
authors.initials: L
authors.lastname: Albayrak
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taşkın
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D018384:Oxidative Stress
chemical_list: D008078:Cholesterol, LDL; D002097:C-Reactive Protein