title: The Cuban Twin Registry: initial findings and perspectives.
abstract: The Cuban Twin Registry is a nation-wide, prospective, population-based twin registry comprising all zygosity types and ages. It was initiated in 2004 to study genetic and environmental contributions to complex diseases with high morbidity and mortality in the Cuban population. The database contains extensive information from 55,400 twin pairs enrolled in the period 2004-2006. Additionally, 2,600 new multiple births have been included from 2007 to date. In the past 4 years, more than 130 studies have been carried out using the registry with a classical genetic epidemiological approach in which concordance rates for monozygotic and dizygotic twins and heritability of various disease traits were estimated. This article summarizes the history, registry's methodology, recent research findings, and future directions of work.
authors.affiliation: National Centre of Medical Genetics, Havana, Cuba. beatriz@infomed.sld.cu
authors.forename: Beatriz
authors.initials: B
authors.lastname: Marcheco-Teruel
authors.forename: Marcia
authors.initials: M
authors.lastname: Cobas-Ruiz
authors.forename: Niviola
authors.initials: N
authors.lastname: Cabrera-Cruz
authors.forename: Araceli
authors.initials: A
authors.lastname: Lantigua-Cruz
authors.forename: Elsa
authors.initials: E
authors.lastname: García-Castillo
authors.forename: Roberto
authors.initials: R
authors.lastname: Lardoeyt-Ferrer
authors.forename: Zoe
authors.initials: Z
authors.lastname: Robaina-Jiménez
authors.forename: Evelyn
authors.initials: E
authors.lastname: Fuentes-Smith
authors.forename: Francisco
authors.initials: F
authors.lastname: Morales-Calatayud
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Lemus-Valdés
authors.forename: Miriam
authors.initials: M
authors.lastname: Portuondo-Sao
authors.forename: Lenier
authors.initials: L
authors.lastname: Comas-Pérez
authors.forename: Juan M
authors.initials: JM
authors.lastname: Pérez-Crispí
authors.forename: Thais
authors.initials: T
authors.lastname: Díaz-De Villal Villa
authors.forename: Emelia
authors.initials: E
authors.lastname: Icart-Perera
authors.forename: Aida
authors.initials: A
authors.lastname: Jordán-Hernández
authors.forename: Agustín
authors.initials: A
authors.lastname: Lage-Castellanos
authors.forename: Sergio
authors.initials: S
authors.lastname: Rabell-Piera
authors.forename: Juan de Jesús
authors.initials: Jde J
authors.lastname: Llibre-Rodríguez
authors.forename: Pedro
authors.initials: P
authors.lastname: Valdés-Sosa
authors.forename: Mitchell
authors.initials: M
authors.lastname: Valdés-Sosa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003462:Cuba / Q000453:epidemiology; D004200:Diseases in Twins / Q000453:epidemiology / Q000235:genetics*; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012042:Registries; D014427:Twins / Q000235:genetics*; D055815:Young Adult