title: Linking glycogen and senescence in cancer cells.
abstract: Glycogen metabolism operates as an alternative energy source, enabling cell growth under conditions of metabolic stress. Favaro et al. (2012) now demonstrate that in hypoxic cancer cells, depletion of liver glycogen phosphorylase causes glycogen accumulation, leading to oxidative stress, induction of senescence, and impaired tumor growth in vivo.
authors.affiliation: Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
authors.forename: Susana
authors.initials: S
authors.lastname: Ros
authors.forename: Almut
authors.initials: A
authors.lastname: Schulze