title: New noninvasive index for evaluation of the vascular age of healthy and sick people.
abstract: We conducted a study on 861 healthy and sick subjects and demonstrated that some calculated parameters based on measurement of the dynamic light scattering (DLS) signal from the finger correlate highly with chronological age ranging from 1.5 to 85 years old. Measurements of DLS signals were obtained during both occlusion and nonocclusion of blood flow in the finger. For the nonocclusion case we found that the low-frequency component of the DLS signal significantly correlates with the biological age while the high-frequency component of the DLS signal resembles the arterial pulse-wave and does correlate with age. However, the most prominent correlation between the DLS characteristics and age was noted with the stasis stage measurements. We propose that the observed age-related phenomena are caused by alterations in local blood viscosity and interactions of the endothelial cells with erythrocytes. Further, a new noninvasive index based on the age-related optical characteristics was introduced. This noninvasive index may be used as a research and diagnostic tool to examine the endothelial and thrombolytic properties of the vascular system.
authors.affiliation: Elfi-Tech Ltd., Science Park, Rehovot, Israel. ilyafine@elfi-tech.com
authors.forename: Ilya
authors.initials: I
authors.lastname: Fine
authors.forename: Boris I
authors.initials: BI
authors.lastname: Kuznik
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kaminsky
authors.forename: Louis
authors.initials: L
authors.lastname: Shenkman
authors.forename: Evgeniya M
authors.initials: EM
authors.lastname: Kustovsjya
authors.forename: Evgeniya M
authors.initials: EM
authors.lastname: Elena
authors.forename: Olga G
authors.initials: OG
authors.lastname: Maximova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001157:Arterial Occlusive Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D001158:Arteries / Q000503:physiopathology*; D001783:Blood Flow Velocity; D002648:Child; D002675:Child, Preschool; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D041622:Tomography, Optical / Q000379:methods*; D055815:Young Adult