title: Copper-catalyzed C-N bond formation through C-H/N-H activation: a novel approach to the synthesis of multisubstituted ureas.
abstract: A copper-catalyzed cross-dehydrogenative coupling reaction that involves C-H activation of formamides and N-H activation of N-alkoxy amides has been developed. This protocol affords a novel approach to the synthesis of multisubstituted ureas under mild conditions.
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, People's Republic of China.
authors.forename: Honglai
authors.initials: H
authors.lastname: Jiang
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zhu
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003300:Copper / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D000577:Amides; D003300:Copper; D014508:Urea