title: [Association of vitamin D receptor gene polymorphisms with urolithiasis in Uyghur children from southern Xinjiang, China].
abstract: OBJECTIVE
  To investigate the association of vitamin D receptor (VDR) gene polymorphisms with urolithiasis in Uyghur children from southern Xinjiang, China, and to clarify the molecular genetic mechanism for the disease.
  
  
  METHODS
  Seventy-four Uygur children with urolithiasis (case group) and 103 healthy Uyghur children (control group) were enrolled as subjects. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze the association of VDR gene FokI and ApaI polymorphisms with urolithiasis in Uyghur children from southern Xinjiang.
  
  
  RESULTS
  There were significant differences in FokI genotypes (FF, Ff and ff) between the case and control groups (χ2=7.818, P<0.05). The genotype Ff accounted for 58% of all genotypes in the case group, and Ff was significantly more prevalent in the case group than in the control group (P<0.05). There were no significant differences in ApaI genotypes (AA, Aa, and aa) between the case and control groups.
  
  
  CONCLUSIONS
  The polymorphisms of VDR gene FokI may be a suitable genetic marker for urolithiasis in Uyghur children.
authors.affiliation: Department of Urology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China. Raysaraji@hotmail.com
authors.forename: Kaysar
authors.initials: K
authors.lastname: Aji
authors.forename: Guang-Lu
authors.initials: GL
authors.lastname: Song
authors.forename: Anwar
authors.initials: A
authors.lastname: Yasen
authors.forename: Bahtiyar
authors.initials: B
authors.lastname: Azad
authors.forename: Halmurat
authors.initials: H
authors.lastname: Tursun
mesh_terms: D002675:Child, Preschool; D002681:China; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D052878:Urolithiasis / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol