title: Patient completion of laboratory tests to monitor medication therapy: a mixed-methods study.
abstract: BACKGROUND
  Little is known about the contribution of patient behavior to incomplete laboratory monitoring, and the reasons for patient non-completion of ordered laboratory tests remain unclear.
  
  
  OBJECTIVE
  To describe factors, including patient-reported reasons, associated with non-completion of ordered laboratory tests.
  
  
  METHODS
  Mixed-Methods study including a quantitative assessment of the frequency of patient completion of ordered monitoring tests combined with qualitative, semi-structured, patient interviews.
  
  
  METHODS
  Quantitative assessment included patients 18 years or older from a large multispecialty group practice, who were prescribed a medication requiring monitoring. Qualitative interviews included a subset of show and no-show patients prescribed a cardiovascular, anticonvulsant, or thyroid replacement medication.
  
  
  METHODS
  Proportion of recommended monitoring tests for each medication not completed, factors associated with patient non-completion, and patient-reported reasons for non-completion.
  
  
  RESULTS
  Of 27,802 patients who were prescribed one of 34 medications, patient non-completion of ordered tests varied (range: 0-24 %, by drug-test pair). Factors associated with higher odds of test non-completion included: younger patient age (< 40 years vs. ≥ 80 years, adjusted odds ratio [AOR] 1.52, 95 % confidence interval [95 % CI] 1.27-1.83); lower medication burden (one medication vs. more than one drug, AOR for non-completion 1.26, 95 % CI 1.15-1.37), and lower visit frequency (0-5 visits/year vs. ≥ 19 visits/year, AOR 1.41, 95 % CI 1.25 to 1.59). Drug-test pairs with black box warning status were associated with greater odds of non-completion, compared to drugs without a black box warning or other guideline for testing (AOR 1.91, 95 % CI 1.66-2.19). Qualitative interviews, with 16 no-show and seven show patients, identified forgetting as the main cause of non-completion of ordered tests.
  
  
  CONCLUSIONS
  Patient non-completion contributed to missed opportunities to monitor medications, and was associated with younger patient age, lower medication burden and black box warning status. Interventions to improve laboratory monitoring should target patients as well as physicians.
authors.affiliation: Beth Israel Deaconess Medical Center, Division of Clinical Informatics, 1330 Beacon St., Suite 400, Brookline, MA 02446, USA. shira_fischer@bidmc.harvard.edu
authors.forename: Shira H
authors.initials: SH
authors.lastname: Fischer
authors.forename: Terry S
authors.initials: TS
authors.lastname: Field
authors.forename: Shawn J
authors.initials: SJ
authors.lastname: Gagne
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Mazor
authors.forename: Peggy
authors.initials: P
authors.lastname: Preusse
authors.forename: George
authors.initials: G
authors.lastname: Reed
authors.forename: Daniel
authors.initials: D
authors.lastname: Peterson
authors.forename: Jerry H
authors.initials: JH
authors.lastname: Gurwitz
authors.forename: Jennifer
authors.initials: J
authors.lastname: Tjia
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000554:Ambulatory Care Facilities; D002908:Chronic Disease / Q000188:drug therapy*; D016903:Drug Monitoring / Q000379:methods / Q000523:psychology* / Q000706:statistics & numerical data; D005260:Female; D006297:Health Services Accessibility / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009511:New England; D010349:Patient Compliance / Q000706:statistics & numerical data*; D055553:Prescription Drugs / Q000009:adverse effects*; D036301:Qualitative Research; D012737:Sex Factors
chemical_list: D055553:Prescription Drugs