title: [Platelet intregrin beta3 A1/A2 polymorphism in women with stillbirth].
abstract: Maternal thrombophilia was recently discussed as possible cause for pregnancy complication, although the roles of some coagulation factors have not been clarified. Carrier status for platelet integrin beta3 polymorphism A1/A2 (PL A1/A2) was considered as possible risk factor for pregnancy complication. Seventy women with one or more stillbirth (intrauterine fetal death after 20 week of gestation) and 100 healthy control subjects were evaluated for PL A1/A2 to assess the impact of polymorphism for late pregnancy loss. The prevalence for PL A1/A2 in women with stillbirth was higher but not significantly differs from carrier status in control subjects (respectively 28.3% and 17%, OR = 1.93; 95% CI: 0.84 - 4.45). After adjustment for carrier status for Factor V Leiden (FVL) and Prothrombin (FII) gene mutation 20210 G > A the prevalence of PL 1/A2 remains a similar (28.2% O R = 1.92; 95% Il: 0.78 - 4.75). Combined carriers status for PL A1/ A2 with FVL or III 20210 G > A have had significantly higher prevalence in investigated group comparing with control subjects (respectively 20% and 2%, p < 0.0001). An independent impact of PL A1/A2 on risk of stillbirth development is not be yet established but additive role of the polymorphism in combination with other thrombophilic factors should be considered.
authors.forename: P
authors.initials: P
authors.lastname: Ivanov
authors.forename: Sv
authors.initials: S
authors.lastname: Gecheva
authors.forename: Tsv
authors.initials: T
authors.lastname: Tsvyatkovska
authors.forename: A
authors.initials: A
authors.lastname: Izmailov
authors.forename: R
authors.initials: R
authors.lastname: Komsa-Penkova
authors.forename: K
authors.initials: K
authors.lastname: Kovacheva
authors.forename: E
authors.initials: E
authors.lastname: Konova
authors.forename: M
authors.initials: M
authors.lastname: Simeonova
authors.forename: St
authors.initials: S
authors.lastname: Tanchev
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics; D050497:Stillbirth; D055815:Young Adult
chemical_list: D039661:Integrin beta3; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin