title: Opioid therapies and cytochrome p450 interactions.
abstract: Adverse drug reactions are common and associated with substantial economic and human costs. Particularly among older adult populations, preventable adverse drug reactions are often caused by drug-drug interactions. All analgesics have side effect profiles and many have known drug-drug interactions. Opioids are recognized as a necessary option for managing moderate-to-severe pain, yet many opioid side effects can be enhanced by metabolic interactions within the liver, involving other drugs, diseases, or genetics.
authors.affiliation: The Pain Management and Wellness Center, Englewood Hospital and Medical Center, Englewood, New Jersey 07631, USA. healthmd@optonline.net
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Gudin
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008954:Models, Biological; D009293:Opioid-Related Disorders / Q000201:enzymology*; D010146:Pain / Q000188:drug therapy* / Q000201:enzymology*
chemical_list: D000701:Analgesics, Opioid; D003577:Cytochrome P-450 Enzyme System