title: Cyclic decapeptide gramicidin S derivatives containing phosphines: novel ligands for asymmetric catalysis.
abstract: The cyclic peptide gramicidin S was used as a rigid template to provide novel peptide-based bisphosphine ligands for transition metal catalysis. Two bisphosphine-coordinated Rh(I) complexes allowed asymmetric hydrogenation with 10-52% ee and the corresponding Pd(II) analogues catalysed asymmetric allylic alkylation with 13-15% ee.
authors.affiliation: EaStCHEM, School of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST, UK.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Guisado-Barrios
authors.forename: Bianca K
authors.initials: BK
authors.lastname: Muñoz
authors.forename: Paul C J
authors.initials: PC
authors.lastname: Kamer
authors.forename: Bas
authors.initials: B
authors.lastname: Lastdrager
authors.forename: Gijs
authors.initials: G
authors.lastname: van der Marel
authors.forename: Mark
authors.initials: M
authors.lastname: Overhand
authors.forename: Marino
authors.initials: M
authors.lastname: Vega-Vázquez
authors.forename: Manuel
authors.initials: M
authors.lastname: Martin-Pastor
mesh_terms: D000478:Alkylation; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D006096:Gramicidin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006865:Hydrogenation; D008024:Ligands; D010165:Palladium / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D010720:Phosphines; D006096:Gramicidin; D010165:Palladium; D012238:Rhodium