title: Organocatalytic asymmetric Michael reaction with acylsilane donors.
abstract: We have developed an organocatalytic asymmetric Michael reaction of acylsilane through the selection of acylsilane substrates and organocatalysts, thus creating a rare example of acylsilane α-alkylation with a chiral guanidine catalyst, which afforded products in good yields and high stereoselectivity. The corresponding adducts described here have also been demonstrated to be useful in the synthesis of unnatural amino acids and biologically active compounds.
authors.affiliation: Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science, Chengdu 610041, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wu
authors.forename: Guangxun
authors.initials: G
authors.lastname: Li
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Fu
authors.forename: Luoting
authors.initials: L
authors.lastname: Yu
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Tang
mesh_terms: D000478:Alkylation; D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D019791:Guanidine / Q000737:chemistry; D015394:Molecular Structure; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D012821:Silanes; D019791:Guanidine