title: Effects of olanzapine on 31P MRS metabolic markers in schizophrenia.
abstract: Antipsychotic drug action might include mechanisms related to normalising phospholipid and high-energy metabolism. We applied brain metabolic imaging with (31)P magnetic resonance spectroscopy ((31)P MRS) and two-dimensional chemical shift imaging to assess changes of metabolism of phospholipids and high-energy phosphates in schizophrenia patients at baseline (four antipsychotic-naïve and three off antipsychotics) and at follow-up, after 6 weeks of treatment with olanzapine. Results indicate a significant increase of adenosine-triphosphate (ATP) in the right inferior temporal cortex and a trend towards ATP decrease in the left cerebellum. This suggests a shift in high-energy phosphates (rather than phospholipids), possibly related to normalisation of functioning in these areas.
authors.affiliation: Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. igor.nenadic@uni-jena.de
authors.forename: Igor
authors.initials: I
authors.lastname: Nenadic
authors.forename: Maren
authors.initials: M
authors.lastname: Dietzek
authors.forename: Kerstin
authors.initials: K
authors.lastname: Langbein
authors.forename: Reinhard
authors.initials: R
authors.lastname: Rzanny
authors.forename: Alexander
authors.initials: A
authors.lastname: Gussew
authors.forename: Jürgen R
authors.initials: JR
authors.lastname: Reichenbach
authors.forename: Heinrich
authors.initials: H
authors.lastname: Sauer
authors.forename: Stefan
authors.initials: S
authors.lastname: Smesny
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010759:Phosphorus Isotopes; D010865:Pilot Projects; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D015415:Biomarkers; D010759:Phosphorus Isotopes; D001569:Benzodiazepines; D000077152:Olanzapine