title: LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL).
abstract: BACKGROUND
  Latent membrane protein (LMP) 1 and LMP2A encoded by Epstein-Barr virus (EBV) are associated with the development of malignancies, but their expression in extranodal NK/T-cell lymphoma, nasal type (ENKTL) and the relationship with clinical characteristics of this disease remain poorly understood. In the present study, we examined the expression of LMP1 and LMP2A in ENKTL, and investigated the correlations between LMP1 and LMP2A expression with clinicopathological characteristics of ENKTL patients.
  
  
  METHODS
  Paraffin sections of surgically removed samples from 16 ENKTL patients were analyzed by immunohistochemistry and the related clinicopathological data were collected and analyzed.
  
  
  RESULTS
  Elevated expression (immunohistochemistry score ≥ 4) of LMP1 and LMP2A was detected in the tumor cells of ENKTL. High LMP1 expression was associated with positive B symptoms (p = 0.012), while high LMP2A expression was related to gender (p = 0.029). The expression of both LMP1 and LMP2A showed significant correlations with patients' overall survival (p = 0.049, p = 0.036).
  
  
  CONCLUSIONS
  LMP1 and LMP2A may be prognostic indicators of survival in patients with ENKTL.
  http://www.diagnosticpathology.diagnomx.eu/vs/2443352538545899.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Nanjing Medical University, No,121 Jiang jia yuan, Nanjing 210011, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Mao
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Zhang
authors.forename: Huijun
authors.initials: H
authors.lastname: Zhu
authors.forename: Hong
authors.initials: H
authors.lastname: Lin
authors.forename: Lin
authors.initials: L
authors.lastname: Xiong
authors.forename: Qing
authors.initials: Q
authors.lastname: Cao
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Qing-Dong
authors.initials: QD
authors.lastname: Li
authors.forename: Jia-Ren
authors.initials: JR
authors.lastname: Xu
authors.forename: Lin-Feng
authors.initials: LF
authors.lastname: Xu
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D016009:Chi-Square Distribution; D005260:Female; D004854:Herpesvirus 4, Human / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D053208:Kaplan-Meier Estimate; D054391:Lymphoma, Extranodal NK-T-Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016612:Paraffin Embedding; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D015854:Up-Regulation; D014763:Viral Matrix Proteins / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins