title: Malakoplakia of the esophagus caused by human papillomavirus infection.
abstract: Malakoplakia is a rare granulomatous disease probably caused by infection and characterized histologically by Michaelis-Gutmann bodies. We report a more rarely seen case esophageal malakoplakia in a 54-year-old woman. She presented with coughing while eating and drinking. Gastroscopy showed yellow nodules in the esophagus, and endoscopic ultrasonography showed a space-occupying lesion in the substratum of the esophageal mucosa. All findings highly resembled esophageal cancer. Histopathological examination finally indentified this space-occupying lesion as malakoplakia and not cancer. Immunohistochemistry showed that she had human papillomavirus (HPV) infection in the esophagus, which indicates that infection was responsible for the malakoplakia. This is believed to be the first case of malakoplakia in the esophagus, and more importantly, we established that HPV infection was the initiator of esophageal malakoplakia.
authors.affiliation: Department of Pathology, Yunnan Province Second People's Hospital, Kunming 650021, Yunnan Province, China. appleyangyali@126.com
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Yang
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Xie
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Tang
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003593:Cytoplasm / Q000378:metabolism; D004724:Endoscopy; D004935:Esophageal Diseases / Q000175:diagnosis* / Q000821:virology; D004947:Esophagus / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005773:Gastroscopy; D006801:Humans; D007150:Immunohistochemistry; D008287:Malacoplakia / Q000175:diagnosis* / Q000821:virology; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D000900:Anti-Bacterial Agents