title: Correlation between cord blood apelin and IGF-1 levels in retinopathy of prematurity.
abstract: OBJECTIVE
  We hypothesized that circulating apelin concentrations in preterm babies might be linked with retinopathy of prematurity (ROP), similar to IGF-1 levels.
  
  
  METHODS
  A total of 97 infants born with a gestational age before 32 weeks in 2007-2009 were screened for ROP at the Gata Haydarpasa Hospital (Turkey). Fourteen of them with classified ROP stage 3-5 comprised our study group.
  
  
  RESULTS
  The non-ROP group had higher apelin and IGF-1 levels than ROP neonates at birth. After 4-6 weeks, postnatal ROP subjects had lower apelin and IGF-1 levels than non-ROP controls. At the end of the study, the change in apelin levels was positively correlated with the change in IGF-1 levels (r = 0.852; p = 0.01).
  
  
  CONCLUSIONS
  We suggested that the pathogenesis of ROP, which is regarded as a neovascular retinal disorder, includes variations in the levels of apelin and IGF-1.
authors.affiliation: GATA Medical Faculty, Department of Pediatrics, Division of Neonatology, Ankara, Turkey. ferhat_cocuk@hotmail.com
authors.forename: Ferhat
authors.initials: F
authors.lastname: Cekmez
authors.forename: Ozgur
authors.initials: O
authors.lastname: Pirgon
authors.forename: Gokhan
authors.initials: G
authors.lastname: Aydemir
authors.forename: Bumin
authors.initials: B
authors.lastname: Dundar
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Cekmez
authors.forename: Abdulbaki
authors.initials: A
authors.lastname: Karaoglu
authors.forename: Kürsat
authors.initials: K
authors.lastname: Fidanc
authors.forename: Turan
authors.initials: T
authors.lastname: Tunc
authors.forename: Secil
authors.initials: S
authors.lastname: Aydinoz
authors.forename: Ferhan
authors.initials: F
authors.lastname: Karademir
authors.forename: Selami
authors.initials: S
authors.lastname: Süleymanoglu
mesh_terms: D000073861:Apelin; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D047928:Premature Birth / Q000097:blood; D012178:Retinopathy of Prematurity / Q000097:blood*
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins; D007334:Insulin-Like Growth Factor I