title: L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?
abstract: We have recently reported immunomodulatory effects for tamoxifen and letrozole on the L-BLP25 (Stimuvax(®))-induced immune response in a MUC1-expressing breast cancer mouse model. While neither tamoxifen nor letrozole appeared to interfere with the Th1-polarized cytokine response induced by L-BLP25, only letrozole increased the survival advantage of L-BLP25.
authors.affiliation: Department of Internal Medicine; Division of Hematology and Oncology; University of California, Davis; Sacramento, CA USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Degregorio
authors.forename: Michael
authors.initials: M
authors.lastname: Degregorio
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Wurz
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Wurz
authors.forename: Audrey
authors.initials: A
authors.lastname: Gutierrez
authors.forename: Audrey
authors.initials: A
authors.lastname: Gutierrez
authors.forename: Michael
authors.initials: M
authors.lastname: Wolf