title: The role of adiponectin multimers in anorexia nervosa.
abstract: OBJECTIVE
  Anorexia nervosa (AN) continues to be a refractory disease because of its unknown pathogenesis. The role of adiponectin in AN has not been clarified. Moreover, few reports have described the relations between adiponectin isoforms and AN in the physical and psychological states. Therefore, we measured plasma adiponectin and its isoforms levels in patients with AN to examine their roles in AN.
  
  
  METHODS
  Eighteen women participated in this study: nine patients with AN and nine age-matched healthy controls. We examined plasma adiponectin and its isoforms levels in all subjects and administered three types of psychological test to patients with AN: the Eating Disorders Inventory-2, the Maudsley Obsessional-Compulsive Inventory, and the Beck Depression Inventory-2.
  
  
  RESULTS
  We found that the percentage of high-molecular-weight (HMW) to total adiponectin (%HMW) was significantly low and the percentage of low-molecular-weight (LMW) to total adiponectin (%LMW) was significantly high in the AN group compared with the control group. The %HMW positively and the %LMW negatively correlated with body mass index in the entire study population. The %HMW was also positively correlated with psychological symptoms such as social insecurity or cleaning evaluated with the Eating Disorders Inventory-2 or the Maudsley Obsessional-Compulsive Inventory.
  
  
  CONCLUSIONS
  Our study indicates that all adiponectin isoforms should be evaluated in patients with AN in addition to total adiponectin. The decreased %HMW and the increased %LMW that were correlated with the body mass index and some components of psychopathology in our patients may indicate a complex role of adiponectin isoforms in maintaining energy homeostasis and emotion during extreme malnourishment.
authors.affiliation: Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Amitani
authors.forename: Akihiro
authors.initials: A
authors.lastname: Asakawa
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ogiso
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nakahara
authors.forename: Miharu
authors.initials: M
authors.lastname: Ushikai
authors.forename: Izumi
authors.initials: I
authors.lastname: Haruta
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Koyama
authors.forename: Marie
authors.initials: M
authors.lastname: Amitani
authors.forename: Kai-chun
authors.initials: KC
authors.lastname: Cheng
authors.forename: Akio
authors.initials: A
authors.lastname: Inui
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000856:Anorexia Nervosa / Q000097:blood* / Q000473:pathology / Q000523:psychology; D015992:Body Mass Index; D016022:Case-Control Studies; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D006801:Humans; D008970:Molecular Weight; D055503:Protein Multimerization; D011594:Psychometrics; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin