title: Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs.
abstract: Activated lymphocytes secrete dendritic cell (DC)-activating cytokines including tumor necrosis factor α and interferon γ, and induce Type-1-polarized DCs (DC1s). Lymphocyte-polarized DC1s secrete high levels of biologically active interleukin-12 (IL-12p70) and CXCL10 and show enhanced CTL-inducing activity. Our data demonstrate the feasibility of using autologous lymphocytes to enhance the immunogenic properties of DCs in a low-cost clinically-compatible process.
authors.affiliation: Department of Sugery; University of Pittsburgh; Pittsburgh, PA USA.
authors.forename: Erik
authors.initials: E
authors.lastname: Berk
authors.forename: Pawel
authors.initials: P
authors.lastname: Kalinski