title: ADHD symptoms and cognitive abilities in the midlife cohort of the PATH through life study.
abstract: OBJECTIVE
  ADHD is a lifelong condition, but it remains understudied in older adults. We examined the effects of ADHD-related inattention and hyperactivity symptoms on cognitive abilities in middle-age adults.
  
  
  METHODS
  ADHD symptoms and cognitive abilities were accessed in a population-based sample (N = 2,091). Multiple regression analyses evaluated the effect of dimensional and categorical measures of ADHD on performance in cognitive tests.
  
  
  RESULTS
  ADHD symptoms are negatively associated with measures of reaction time, processing speed, task-switching, mental flexibility, and an aggregate measure of cognition. Inattention and hyperactive symptoms have reciprocal effects on performance in some cognitive tasks. Significant subclinical effects are present.
  
  
  CONCLUSIONS
  Our demonstration that cognitive effects of ADHD symptoms are present in the middle-age population provides the impetus to investigate whether these effects contribute to cognitive decline in late age and whether identification and treatment of ADHD symptoms in middle age might be effective in reducing late-age cognitive decline.
authors.affiliation: Australian National University, Canberra, Australia debjani.das@anu.edu.au.
authors.forename: Debjani
authors.initials: D
authors.lastname: Das
authors.affiliation: Australian National University, Canberra, Australia.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Cherbuin
authors.affiliation: Australian National University, Canberra, Australia.
authors.forename: Kaarin J
authors.initials: KJ
authors.lastname: Anstey
authors.affiliation: Australian National University, Canberra, Australia.
authors.forename: Simon
authors.initials: S
authors.lastname: Easteal
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000523:psychology; D001288:Attention / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000523:psychology*; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology*; D003866:Depressive Disorder / Q000523:psychology; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000523:psychology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D011930:Reaction Time / Q000502:physiology; D012044:Regression Analysis; D055815:Young Adult