title: Assessment of autoantibodies to meningioma in a population-based study.
abstract: Meningioma is an intracranial tumor with few confirmed risk factors. Recent research points to an impact on meningioma risk from factors related to immune function and development, such as allergy, immunoglobulin E, and Varicella infection status. To further explore an association with immune function, the authors assessed individual seroreactivity to meningioma tumor-associated antigens among participants enrolled in a multicenter, population-based US case-control study of meningioma (2006-2009). Serum samples from cases (n = 349) and controls (n = 348) were screened for autoantibody reactivity to 3 proteins identified in previous studies: enolase 1 (ENO1), NK-tumor recognition protein (NKTR), and nuclear mitotic apparatus protein 1 (NUMA1). Case-control differences were not strong overall (adjusted odds ratio (OR)(ENO1 (continuous)) = 1.1, 95% confidence interval (CI): 0.6, 1.9 (P(trend) = 0.3); adjusted OR(NKTR (continuous)) = 1.3, 95% CI: 0.7, 2.4 (P(trend) = 0.02); and adjusted OR(NUMA1 (continuous)) = 1.1, 95% CI: 0.7, 1.8 (P(trend) = 0.06)); however, antibodies to NKTR and NUMA1 were detected at higher levels in cases than in controls, particularly among men (for men, adjusted OR(ENO1 (continuous)) = 1.6, 95% CI: 0.5, 4.7 (P(trend) = 0.24); adjusted OR(NKTR (continuous)) = 4.3, 95% CI: 1.2, 15 (P(trend) = 0.009); and adjusted OR(NUMA1 (continuous)) = 3.6, 95% CI: 1.1, 11 (P(trend) = 0.006)). These results indicate that men with meningioma commonly react with a serologic antimeningioma response; if supported by further research, this finding suggests a distinctive etiology for meningioma in men.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Medicine, Helen Diller Cancer Research Building, University of California, San Francisco, 1450 3rd Street, MC 0520, San Francisco, CA 94158, USA. joe.wiemels@ucsf.edu
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Wiemels
authors.forename: Paige M
authors.initials: PM
authors.lastname: Bracci
authors.forename: Margaret
authors.initials: M
authors.lastname: Wrensch
authors.forename: Joellen
authors.initials: J
authors.lastname: Schildkraut
authors.forename: Melissa
authors.initials: M
authors.lastname: Bondy
authors.forename: Jon
authors.initials: J
authors.lastname: Pfefferle
authors.forename: Mi
authors.initials: M
authors.lastname: Zhou
authors.forename: Jennette
authors.initials: J
authors.lastname: Sison
authors.forename: Lisa
authors.initials: L
authors.lastname: Calvocoressi
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Claus
mesh_terms: D000328:Adult; D000368:Aged; D034961:Antigens, Nuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins / Q000097:blood; D004485:Eczema / Q000453:epidemiology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D008297:Male; D008579:Meningioma / Q000097:blood* / Q000453:epidemiology / Q000276:immunology*; D008875:Middle Aged; D034521:Nuclear Matrix-Associated Proteins / Q000097:blood; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011971:Receptors, Immunologic / Q000097:blood; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology; D012959:Socioeconomic Factors; D025521:Tumor Suppressor Proteins / Q000097:blood; D014481:United States
chemical_list: D034961:Antigens, Nuclear; D001323:Autoantibodies; D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C081849:NKTR protein, human; C050045:NUMA1 protein, human; D034521:Nuclear Matrix-Associated Proteins; D011971:Receptors, Immunologic; D025521:Tumor Suppressor Proteins; C095157:ENO1 protein, human; D010751:Phosphopyruvate Hydratase