title: Transcriptional regulation of ncx1 gene in the brain.
abstract: The ubiquitous sodium-calcium exchanger isoform 1 (NCX1) is a -bidirectional transporter that plays a relevant role under physiological and pathophysiological conditions including brain ischemia by regulating intraneuronal Ca(2+) and Na(+) homeostasis. Although changes in ncx1 protein and transcript expression have been detected during stroke, its transcriptional regulation is still largely unexplored. Here, we reviewed our recent findings on several transcription factors including cAMP response element-binding protein (CREB), nuclear factor kappa B (NF-κB), and hypoxia-inducible factor-1 (HIF-1) in the control of the ncx1 gene expression in neuronal cells.
authors.affiliation: Department of Neuroscience, Federico II University of Naples, Naples, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Valsecchi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pignataro
authors.forename: Rossana
authors.initials: R
authors.lastname: Sirabella
authors.forename: Carmela
authors.initials: C
authors.lastname: Matrone
authors.forename: Francesca
authors.initials: F
authors.lastname: Boscia
authors.forename: Antonella
authors.initials: A
authors.lastname: Scorziello
authors.forename: Maria Josè
authors.initials: MJ
authors.lastname: Sisalli
authors.forename: Elga
authors.initials: E
authors.lastname: Esposito
authors.forename: Nicola
authors.initials: N
authors.lastname: Zambrano
authors.forename: Mauro
authors.initials: M
authors.lastname: Cataldi
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Di Renzo
authors.forename: Lucio
authors.initials: L
authors.lastname: Annunziato
mesh_terms: D000818:Animals; D001921:Brain; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D012964:Sodium / Q000378:metabolism; D019831:Sodium-Calcium Exchanger / Q000096:biosynthesis*; D020521:Stroke / Q000378:metabolism* / Q000473:pathology; D014158:Transcription, Genetic
chemical_list: C115163:CREB1 protein, human; D017362:Cyclic AMP Response Element-Binding Protein; D051793:Hypoxia-Inducible Factor 1; D016328:NF-kappa B; D009419:Nerve Tissue Proteins; D019831:Sodium-Calcium Exchanger; C110374:sodium-calcium exchanger 1; D012964:Sodium; D002118:Calcium