title: [Clinicopathological characteristics of ten cases of advanced gastric carcinoma after S-1 combined with cisplatin administered as neoadjuvant chemotherapy].
abstract: OBJECTIVE
  Although neoadjuvant chemotherapy(NAC)has been recognized as an important option for improving the clinical outcome of patients with advanced gastric carcinoma, convincing evidence that it prolongs life and brings about a good prognosis are both lacking. We retrospectively evaluated the efficacy and safety of NAC in ten patients with advanced gastric cancer.
  
  
  METHODS
  A total of ten patients with advanced gastric cancer, who received NAC with the combination of S-1 and cisplatin in our hospital from April 2008 to March 2010, were retrospectively investigated.
  
  
  RESULTS
  A total of 5 patients responded to neoadjuvant chemotherapy, and 2 patients showed a complete regression of the primary gastric carcinoma. Four of the 5 patients who responded had solid-type poorly-differentiated adenocarcinoma.
  
  
  CONCLUSIONS
  NAC with the combination of S-1 and cisplatin was suggested to be effective for advanced gastric carcinoma, especially for solid-type poorly differentiated adenocarcinomas(por1).
authors.affiliation: Dept. of Gastroenterological Surgery, Ishikawa Prefectural Central Hospital, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ishiyama
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Inaki
authors.forename: Hironari
authors.initials: H
authors.lastname: No
authors.forename: Masashi
authors.initials: M
authors.lastname: Matsunaga
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kitamura
authors.forename: Michihiro
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Kotake
authors.forename: Masaru
authors.initials: M
authors.lastname: Kurokawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Bando
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Yamada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin