title: High incidence of pseudotumours after hip resurfacing even in low risk patients; results from an intensified MRI screening protocol.
abstract: We intensified our screening protocol for the presence of pseudotumours in a consecutive series of patients with a hip resurfacing arthroplasty (HRA), to establish whether we should be alert to the presence of 'silent' pseudotumours. Patients categorised with high risk (11 hips) and low risk (10 hips) for pseudotumour development and a control group (23 hips) were screened with metal artefact reduction sequence (MARS) magnetic resonance imaging (MRI). The Anderson classification to grade any metal-on-metal (MoM) disease present on MARS-MRI images was used. In 15 out of 44 MRI scans pseudotumours were observed (34.1%), of which six were graded with mild (13.6%), eight with moderate (18.2%) and one with severe MoM disease (2.3%). Twelve pseudotumours were present in asymptomatic patients (27.3%). Metal ion levels were normal in 80% of the MARS-MRI screened patients. As a consequence of our intensified screening protocol, one patient was revised for pseudotumour formation and another patient was scheduled for revision. Silent pseudotumours were observed in all three groups. Before our intensified screening protocol was initiated, no pseudotumours were encountered in our cohort of 289 HRAs. We concluded that clinical outcomes and plain radiographs for screening MoM patients underestimates the presence of pseudotumours in MoM patients. The true clinical relevance of these pseudotumours is still unclear.
authors.affiliation: Department of Orthopaedic Surgery, St. Anna Hospital, Geldrop 5664EH, The Netherlands. kog@st-anna.nl
authors.forename: Walter
authors.initials: W
authors.lastname: van der Weegen
authors.forename: Jose M H
authors.initials: JM
authors.lastname: Smolders
authors.forename: Thea
authors.initials: T
authors.lastname: Sijbesma
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Hoekstra
authors.forename: Koen
authors.initials: K
authors.lastname: Brakel
authors.forename: Job L C
authors.initials: JL
authors.lastname: van Susante
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006104:Granuloma, Plasma Cell / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D011474:Prosthesis Design; D012086:Reoperation; D012189:Retrospective Studies