title: MicroRNA miR-155 affects antiviral effector and effector Memory CD8 T cell differentiation.
abstract: MicroRNAs are key regulators of the immune response, but their role in CD8 T cell differentiation in vivo is not known. We show that miR-155 is important in both effector and memory antiviral CD8 T cell responses. Without miR-155, there was a weaker effector response and a skewing toward memory precursor cells. At the memory stage, miR-155-deficient CD8 T cells preferentially differentiated into central memory cells and were capable of mounting a potent secondary response.
authors.affiliation: Microbiology and Immunology Department, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA.
authors.forename: Ching-Yi
authors.initials: CY
authors.lastname: Tsai
authors.forename: S Rameeza
authors.initials: SR
authors.lastname: Allie
authors.forename: Weijun
authors.initials: W
authors.lastname: Zhang
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Usherwood
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D007156:Immunologic Memory; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014780:Viruses / Q000276:immunology*
chemical_list: D035683:MicroRNAs; C532623:Mirn155 microRNA, mouse