title: Design and characterization of sustained release mucoadhesive microspheres of tolterodine tartrate.
abstract: The work was aim to design and characterize the sustained release mucoadhesive microspheres of Tolterodine tartrate prepared by non-aqueous solvent evaporation technique using ethyl cellulose based selected mucoadhesive polymers. Selected microspheres formulations of were found to be discrete, spherical and free flowing from the preliminary formulations. The microspheres exhibit good mucoadhesive property in in-vitro wash off test and showed high drug entrapment efficiency. Tolterodine tartrate release from these microspheres was slowed, extended and depended on the concentration of ethyl cellulose and type of mucoadhesive polymer used. In vitro drug release studies suggested that formulation F6c showed consistent drug release for up to 24 h time period. Among all the formulations, F6c containing ethyl cellulose with chitosan showed the reproducible results with best mucoadhesive profile and good surface morphology. The correlation value (r(2)) indicated that the drug release followed Higuchi model. Analysis of variance (ANOVA) showed significant difference in the release of drug from all formulations at P < 0.05 level. Accelerated stability study of optimized formulation (F6c) up to 3 month showed there was no change in drug content and release characteristics during storage.
authors.affiliation: Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur (Ganjam), Odisha-760 010, India. swain_suryakant@yahoo.co.in/suryakantarips@gmail.com
authors.forename: Suryakanta
authors.initials: S
authors.lastname: Swain
authors.forename: Dusmant
authors.initials: D
authors.lastname: Meher
authors.forename: Chinam Niranjan
authors.initials: CN
authors.lastname: Patra
authors.forename: Jammula
authors.initials: J
authors.lastname: Sruti
authors.forename: Subas Chandra
authors.initials: SC
authors.lastname: Dinda
authors.forename: Muddana Eswara Bhanoji
authors.initials: ME
authors.lastname: Rao
mesh_terms: D000268:Adhesiveness; D000818:Animals; D001559:Benzhydryl Compounds / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003408:Cresols / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D016503:Drug Delivery Systems; D004355:Drug Stability; D006041:Goats; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000737:chemistry; D008863:Microspheres; D018727:Muscarinic Antagonists / Q000737:chemistry*; D010316:Particle Size; D010665:Phenylpropanolamine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D000068737:Tolterodine Tartrate; D044366:Transition Temperature
chemical_list: D001559:Benzhydryl Compounds; D003408:Cresols; D003692:Delayed-Action Preparations; D018727:Muscarinic Antagonists; D011108:Polymers; D010665:Phenylpropanolamine; D000068737:Tolterodine Tartrate