title: Synthesis of fluorinated cyclopropyl amino acid analogues: toward the synthesis of original fluorinated peptidomimetics.
abstract: A straightforward, easy, and practical access to various amino acid analogues (methionine, leucine, lysine, and arginine) from a unique fluorinated cyclopropane scaffold is described. Moreover, the synthesis, for the first time, of one tripeptide incorporating a fluorinated cyclopropane amino acid (FCAA) analogue is reported.
authors.affiliation: INSA de Rouen, UMR 6014 & FR 3038, COBRA Université de Rouen, 1 rue Tesnière, 76131 Mont-Saint-Aignan Cedex, France.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Milanole
authors.forename: Samuel
authors.initials: S
authors.lastname: Couve-Bonnaire
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Bonfanti
authors.forename: Philippe
authors.initials: P
authors.lastname: Jubault
authors.forename: Xavier
authors.initials: X
authors.lastname: Pannecoucke
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D001120:Arginine / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry*; D054879:Halogenation; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007930:Leucine / Q000737:chemistry*; D008715:Methionine / Q000737:chemistry*; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D003521:Cyclopropanes; D006845:Hydrocarbons, Fluorinated; D009842:Oligopeptides; D057786:Peptidomimetics; D001120:Arginine; C030797:cyclopropane; D008715:Methionine; D007930:Leucine