title: [The association of eccentricity indexes with cardiac biomarkers in normotensive acute pulmonary embolism patients: an observational study].
abstract: OBJECTIVE
  The present study aims at investigating the association of systolic and diastolic eccentricity indexes with cardiac biomarkers in hemodynamically stable patients with acute pulmonary embolism (APE).
  
  
  METHODS
  Thirty hemodynamically stable (systolic blood pressure >90 mmHg) patients with APE (17M, mean age 61.67±17.6 years) were included in this cross-sectional observational study. The associations of serum troponin I, D-dimer, brain natriuretic peptide (BNP) and heart type fatty acid binding protein (hFABP) levels with systolic and diastolic eccentricity indices, tricuspid annular plane systolic excursion (TAPSE), myocardial performance index (MPI), systolic pulmonary artery pressure and the index of the inferior vena cava were investigated. The relationships between parameters were evaluated by Pearson and Spearman correlation analysis according to the distribution of data.
  
  
  RESULTS
  Correlation analysis revealed that the most significant relationship between cardiac biomarkers and echocardiographic measurements was in the BNP value. Meanwhile, systolic and diastolic eccentricity indexes were found to have significant correlation with serum troponin I (respectively r=0.470, p=0.009/r=0.310, p=0.095) and BNP (respectively r=0.402, p=0.028/r=0.384, p=0.036) values. On the other hand, elevated D-dimer levels led to statistical significance in none of the echocardiographic parameters.
  
  
  CONCLUSIONS
  According to our results, hFABP was rarely positive in normotensive patients with APE. An elevated D-dimer alone was not significant in predicting RVD. Eccentricity indexes revealed significant relationship with BNP and troponin I values. The results obtained indicate that early echocardiographic evaluation is important in patients with abnormal cardiac biomarkers.
authors.affiliation: Zonguldak Karadeniz Ereğli Devlet Hastanesi, Kardiyoloji Kliniği, Zonguldak, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Cetiner
authors.forename: Muhammet Raşit
authors.initials: MR
authors.lastname: Sayın
authors.forename: Nesligül
authors.initials: N
authors.lastname: Yıldırım
authors.forename: Turgut
authors.initials: T
authors.lastname: Karabağ
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aydın
mesh_terms: D015415:Biomarkers / Q000097:blood*; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011237:Predictive Value of Tests; D011655:Pulmonary Embolism / Q000097:blood / Q000503:physiopathology*; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins; D005338:Fibrin Fibrinogen Degradation Products; D019210:Troponin I; C036309:fibrin fragment D; D020097:Natriuretic Peptide, Brain