title: Chiral Indoline Synthesis Via Enantioselective Intramolecular Copper-Catalyzed Alkene Hydroamination.
abstract: An enantioselective copper-catalyzed hydroamination / cyclization of N-sulfonyl-2-allylanilines for the synthesis of chiral 2-methylindolines is reported. Chiral 2-methylindolines are important subunits in drugs and bioactive compounds. This method provides chiral N-sulfonyl-2-methyl indolines in up to 90% ee.
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260.
authors.forename: Benjamin W
authors.initials: BW
authors.lastname: Turnpenny
authors.forename: Kiante L
authors.initials: KL
authors.lastname: Hyman
authors.forename: Sherry R
authors.initials: SR
authors.lastname: Chemler