title: Continuum- and particle-based modeling of shapes and dynamics of red blood cells in health and disease.
abstract: We review recent advances in multiscale modeling of the mechanics of healthy and diseased red blood cells (RBCs), and blood flow in the microcirculation. We cover the traditional continuum-based methods but also particle-based methods used to model both the RBCs and the blood plasma. We highlight examples of successful simulations of blood flow including malaria and sickle cell anemia.
authors.affiliation: Division of Applied Mathematics, Brown University, Providence, RI 02912, USA.
authors.forename: Xuejin
authors.initials: X
authors.lastname: Li
authors.forename: Petia M
authors.initials: PM
authors.lastname: Vlahovska
authors.forename: George Em
authors.initials: GE
authors.lastname: Karniadakis