title: Free radical scavenging activity of novel thiazolidine-2,4-dione derivatives.
abstract: Free radical activity towards superoxide anion radical (O2•¯), hydroxyl radical (HO(•)) and 2,2-diphenyl-1-picrylhydrazyl (DPPH(•)) of a series of novel thiazolidine-2,4-dione derivatives (TSs) was examined using chemiluminescence, electron paramagnetic resonance (EPR) and EPR spin trapping techniques. 5,5-Dimethyl-1-pyrroline-N-oxide (DMPO) was applied as the spin trap. Superoxide radical was produced in the potassium superoxide/18-crown-6 ether dissolved in dimethyl sulfoxide. Hydroxyl radical was generated in the Fenton reaction (Fe(II) + H2O2. It was found that TSs showed a slight scavenging effect (15-38% reduction at 2.5 mmol/L concentration) of the DPPH radical and a high scavenging effect of O2•¯ (41-88%). The tested compounds showed inhibition of HO(•)-dependent DMPO-OH spin adduct formation (the amplitude of EPR signal decrease ranged from 20 to 76% at 2.5 mmol/L concentration. Our findings present new group compounds of relatively high reactivity towards free radicals.
authors.affiliation: Institute of Physics, Faculty of Mechanical Engineering and Mechatronics, West Pomeranian University of Technology in Szczecin, Al. Piastów 48/49, 70-311, Szczecin, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Berczyński
authors.forename: Irena
authors.initials: I
authors.lastname: Kruk
authors.forename: Teresa
authors.initials: T
authors.lastname: Piechowska
authors.forename: Meltem
authors.initials: M
authors.lastname: Ceylan-Unlusoy
authors.forename: Oya
authors.initials: O
authors.lastname: Bozdağ-Dündar
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Aboul-Enein
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000737:chemistry*; D049449:Luminescence; D015394:Molecular Structure; D045162:Thiazolidinediones / Q000737:chemistry*
chemical_list: D016166:Free Radical Scavengers; D045162:Thiazolidinediones; C500090:thiazolidine-2,4-dione