title: BDKRB2 +9/-9 polymorphism is associated with higher risk for diabetes mellitus in the Brazilian general population.
abstract: Some mechanisms have been proposed to explain the role of bradykinin on glucose homeostasis and some studies reported that the BDKRB2 +9/-9 polymorphism was associated to the transcriptional activity of the receptor. In this scenario, the main aim of this study was to evaluate the association of the BDKRB2 +9/-9 polymorphism with diabetes mellitus risk in the Brazilian general population. This study included 1,032 subjects of the general urban population. Anthropometrical, blood pressure, biochemical, and genotype analyses for the BDKRB2 +9/-9 bp insertion/deletion polymorphism were performed. Individuals carrying +9/+9 or +9/-9 genotypes had higher glucose values (84.5 mg/dL versus 80.6 mg/dL, resp.) and higher frequency of diabetes mellitus (7.6% versus 3.6%, resp.) compared to individuals carrying -9/-9, adjusting for age and gender. In addition, higher diabetes mellitus risk was associated to presence of the +9/+9 or +9/-9 genotypes (OR = 1.91; 95% CI = 1.09-4.19; P = 0.03). Our data suggest that the BDKRB2 +9/-9 polymorphism may act as a genetic modulator of glucose homeostasis. It was previously associated to insulin sensitivity, glucose uptake, and insulin secretion, and, in this study, data suggest that the polymorphism may increase susceptibility to chronic metabolic conditions such as diabetes in the Brazilian population.
authors.affiliation: Laboratory of Genetics and Molecular Cardiology, Heart Institute-InCor, University of Sao Paulo Medical School, Avenida Dr. Enéas de Carvalho Aguiar, 44 Cerqueira César, 05403-000 São Paulo, SP, Brazil.
authors.forename: Rafael
authors.initials: R
authors.lastname: de Oliveira Alvim
authors.forename: Paulo C J L
authors.initials: PC
authors.lastname: Santos
authors.forename: Raimundo M
authors.initials: RM
authors.lastname: Nascimento
authors.forename: George L L M
authors.initials: GL
authors.lastname: Coelho
authors.forename: José G
authors.initials: JG
authors.lastname: Mill
authors.forename: José E
authors.initials: JE
authors.lastname: Krieger
authors.forename: Alexandre C
authors.initials: AC
authors.lastname: Pereira
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D001938:Brazil; D016009:Chi-Square Distribution; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D043782:Receptor, Bradykinin B2 / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014504:Urban Health
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D043782:Receptor, Bradykinin B2; D014280:Triglycerides; D002784:Cholesterol