title: Plasmid content of a clinically relevant Klebsiella pneumoniae clone from the Czech Republic producing CTX-M-15 and QnrB1.
abstract: The entire plasmid content of a multidrug-resistant, CTX-M-15-producing Klebsiella pneumoniae ST416 clone was investigated. Two FII(K) plasmids, pKDO1 (127 kb) and pKPN-CZ (207 kb), were identified and found to carry a formidable set of genes conferring resistance to toxic compounds, metals, and antimicrobial drugs and exhibiting novel features putatively associated with adaptation and fitness of the bacterium in the human host.
authors.affiliation: Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
authors.forename: Monika
authors.initials: M
authors.lastname: Dolejska
authors.forename: Laura
authors.initials: L
authors.lastname: Villa
authors.forename: Hana
authors.initials: H
authors.lastname: Dobiasova
authors.forename: Daniela
authors.initials: D
authors.lastname: Fortini
authors.forename: Claudia
authors.initials: C
authors.lastname: Feudi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Carattoli
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000378:metabolism*; D018153:Czech Republic; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D007710:Klebsiella Infections / Q000188:drug therapy; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics*; D008670:Metals / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D001618:beta-Lactamases / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D008670:Metals; C485385:Qnr protein, Klebsiella pneumoniae; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases