title: [Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology].
abstract: OBJECTIVE
  To optimize the parameters of extraction technology for Puerarin from Pueraria lobata by Central Composite Design-Response Surface Methodology.
  
  
  METHODS
  Used the ratio of dosage liquid and extraction time as the examination factor,the content of puerarin for the extraction percentage as the index. The multielement linear model and the polynomial model were used to describe the mathematics relation with response surface.
  
  
  RESULTS
  The optimal extraction technology was as follows: ratio of herb-to-solvant was 1: 8.88 (W/V) and extraction time was 150 min. The coefficient correlation was 0.9977 and closed to the predicted value.
  
  
  CONCLUSIONS
  The results are accordant with model predictions. The technology can be used as the extraction process of puerarin from Pueraria lobata.
authors.affiliation: The People's Hospital of Linxia, Linxia 731100, China. edusxy1105@126.com
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Sun
authors.forename: Yong-Ling
authors.initials: YL
authors.lastname: Zhang
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Zhang
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Luo
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D007529:Isoflavones / Q000302:isolation & purification*; D015233:Models, Statistical; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029908:Pueraria / Q000737:chemistry*; D012107:Research Design; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D007529:Isoflavones; C033607:puerarin