title: Antiretroviral therapy promotes an inflammatory-like pattern of human T-cell lymphotropic virus type 1 (HTLV-1) replication in human immunodeficiency virus type 1/HTLV-1 co-infected individuals.
abstract: Upon antiretroviral therapy (ART) human immunodeficiency virus (HIV)/human T-cell lymphotropic virus type 1 (HTLV-1) co-infected individuals frequently develop neurological disorders through hitherto unknown mechanisms. Here, we show that effective anti-HIV ART increases HTLV-1 proviral load through a polyclonal integration pattern of HTLV-1 in both CD4(+) and CD8(+) T-cell subsets that is reminiscent of that typically associated with HTLV-1-related inflammatory conditions. These data indicate that preventing ART-triggered clonal expansion of HTLV-1-infected cells in co-infected individuals deserves investigation.
authors.affiliation: Université de Lyon 1, CNRS UMR5239, Oncovirology and Biotherapies, Centre Léon Bérard, Lyon, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Pomier
authors.affiliation: Université de Lyon 1, CNRS UMR5239, Oncovirology and Biotherapies, Centre Léon Bérard, Lyon, France.
authors.forename: Samira
authors.initials: S
authors.lastname: Rabaaoui
authors.affiliation: Laboratoire des Interactions Virus-Hôtes, Institut Pasteur de la Guyane, French Guiana.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Pouliquen
authors.affiliation: Service de dermatologie, Centre hospitalier de Cayenne, Cayenne, French Guiana.
authors.forename: Pierre
authors.initials: P
authors.lastname: Couppié
authors.affiliation: Hôpital de Jour Adultes, Centre Hospitalier de Cayenne, Cayenne, French Guiana.
authors.forename: Myriam
authors.initials: M
authors.lastname: El Guedj
authors.affiliation: Centre d'Investigation Clinique Epidemiologie Clinique Antilles Guyane CIC-EC INSERM CIE 802, Centre Hospitalier de Cayenne, Cayenne, French Guiana.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Nacher
authors.affiliation: Laboratoire des Interactions Virus-Hôtes, Institut Pasteur de la Guyane, French Guiana.
authors.forename: Vincent
authors.initials: V
authors.lastname: Lacoste
authors.affiliation: Service d'Hématologie, Pavillon Marcel Bérard, Centre Hospitalier Lyon-Sud 165, Chemin du Grand Revoyet, 69495 Pierre Bénite Cedex, France.|Present address: Université de Lyon 1, CNRS UMR5239, Oncovirologie et Biothérapies, Faculté de Médecine Lyon Sud, ENS - HCL, Pierre Bénite, France.|Université de Lyon 1, CNRS UMR5239, Oncovirology and Biotherapies, Centre Léon Bérard, Lyon, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Wattel
authors.affiliation: Institut Pasteur de Bangui, Central African Republic.
authors.forename: Mirdad
authors.initials: M
authors.lastname: Kazanji
authors.affiliation: Present address: Université de Lyon 1, CNRS UMR5239, Oncovirologie et Biothérapies, Faculté de Médecine Lyon Sud, ENS - HCL, Pierre Bénite, France.|Université de Lyon 1, CNRS UMR5239, Oncovirology and Biotherapies, Centre Léon Bérard, Lyon, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Mortreux
mesh_terms: D044966:Anti-Retroviral Agents / Q000008:administration & dosage* / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects / Q000379:methods*; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000821:virology; D060085:Coinfection / Q000188:drug therapy; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D015490:HTLV-I Infections / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D011533:Proviruses / Q000187:drug effects / Q000302:isolation & purification; D019562:Viral Load; D016662:Virus Integration / Q000187:drug effects; D014779:Virus Replication
chemical_list: D044966:Anti-Retroviral Agents