title: [Noncardiogenic pulmonary edema in the course of poisoning with clozapine, ketoprofen and thiethylperazine].
abstract: Pulmonary edema is a severe, potentially fatal clinical condition. It happens, when interstitial fluid is accumulating in the alveoli, impeding proper gas exchange. Typically we distinguish cardiogenic and noncardiogenic pulmonary edema. The article describes the case of severe pulmonary edema, which occurred in a young woman, free of cardiac diseases, about 30 hours after a suicidal drug poisoning (clozapine, ketoprofen, thiethylperazine). Both clozapine and ketoprofen intoxication, may be severe. Complications in these poisonings affect not only the central nervous system, but also the circulatory or respiratory system and may even occur several hours after the overdose of these drugs. The study considered the causes and possible mechanisms of pulmonary edema in poisoning with these drugs.
authors.affiliation: Samodzielny Publiczny Szpital Wojewódzki im. Jana Bozego w Lublinie, Regionalny Ośrodek Toksykologii Klinicznej.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Majewska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kołodziej
authors.forename: Jarosław
authors.initials: J
authors.lastname: Szponar
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Drelich
authors.forename: Piotr
authors.initials: P
authors.lastname: Danielewicz
authors.forename: Halina
authors.initials: H
authors.lastname: Kostek
mesh_terms: D000328:Adult; D003024:Clozapine / Q000506:poisoning*; D045424:Complex Mixtures / Q000506:poisoning; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000506:poisoning*; D011654:Pulmonary Edema / Q000139:chemically induced*; D013406:Suicide, Attempted; D013847:Thiethylperazine / Q000506:poisoning*
chemical_list: D045424:Complex Mixtures; D013847:Thiethylperazine; D007660:Ketoprofen; D003024:Clozapine