title: Brain lipid composition in rabbits after total parenteral nutrition with two different lipid emulsions.
abstract: OBJECTIVE
  To study the changes occurring in brain lipid composition after the administration of total parenteral nutrition (TPN) by comparing two lipid emulsions, one with long-chain triacylglycerols (LCT) and the other with long-chain and medium-chain triacylglycerols (MCT/LCT 50%/50%).
  
  
  METHODS
  We used 21 young New Zealand rabbits divided into three groups of seven animals each. Two groups were subjected to TPN for 7 d, with each group receiving using one of two different lipid emulsions: Intralipid 20% (group LCT) and Lipofundin MCT/LCT 20% (group MCT/LCT). The third control group received an oral diet and underwent the same surgical procedure with the administration of intravenous saline solution. The energy administered in the TPN formulas was non-protein 100 kcal ∙ kg(-1) ∙ d(-1), with 40% corresponding to fats.
  
  
  RESULTS
  There were modest increases in plasma cholesterol and triacylglycerols. In the brain tissue, there was a decrease of phosphatidylcholine in animals with TPN, which was greater in group LCT. There were no significant differences in the overall percentage distribution of brain fatty acids among the groups.
  
  
  CONCLUSIONS
  The lipid emulsions administered in TPN, especially those prepared exclusively with LCT, cause changes in the brain lipid polar fractions of young rabbits.
authors.affiliation: Internal Medicine Service, Hospital Perpetuo Socorro, Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Maciá-Botejara
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Morán-Penco
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Espín-Jaime
authors.forename: Francisco
authors.initials: F
authors.lastname: Botello-Martínez
authors.forename: Jesús
authors.initials: J
authors.lastname: Salas-Martínez
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Caballero-Loscos
authors.forename: Manuel
authors.initials: M
authors.lastname: Molina-Fernández
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002784:Cholesterol / Q000097:blood; D004338:Drug Combinations; D004655:Emulsions / Q000008:administration & dosage / Q000737:chemistry; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000737:chemistry*; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis* / Q000097:blood; D010289:Parenteral Nutrition, Total / Q000379:methods*; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000008:administration & dosage / Q000737:chemistry; D011817:Rabbits; D013012:Sorbitol / Q000008:administration & dosage / Q000737:chemistry; D013024:Soybean Oil / Q000008:administration & dosage / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
chemical_list: D004338:Drug Combinations; D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D008055:Lipids; D010713:Phosphatidylcholines; D010743:Phospholipids; D014280:Triglycerides; C545823:soybean oil, phospholipid emulsion; C008288:Lipofundin; D013012:Sorbitol; D013024:Soybean Oil; D002784:Cholesterol