title: [Comparative examination of preparation time in docetaxel hydrate formulation].
abstract: Docetaxel hydrate(DTX), a taxane anticancer drug, is known to be effective against a wide range of cancers, including breast cancer and non-small cell lung cancer. The DTX preparation Taxotere(2-vial DTX)has conventionally required dissolution in the attached solvent, while Onetaxotere(1-vial DTX), a newer product, is provided as a solution. This allows reduction of preparation time, so that improvement in operational efficiency can be expected. In this study, we measured the actual preparation time for 2-vial DTX and 1-vial DTX to compare their usefulness. The median preparation time for 2-vial DTX(n=84)and 1-vial DTX(n=84)was significantly different, with the respective values being 6. 52 minutes and 2. 67 minutes(p<0. 01). By switching to 1-vial DTXfrom 2-vial DTX, which requires preparation of a premix solution with the attached solvent, the preparation procedure in daily practice becomes more convenient. This is because of a shorter preparation time as well as a lower risk of contamination, suggesting the usefulness of 1-vial DTX.
authors.affiliation: Dept. of Pharmacy, Juntendo University Urayasu Hospital, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Arii
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ikeno
authors.forename: Kumi
authors.initials: K
authors.lastname: Narita
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Murooka
authors.forename: Michio
authors.initials: M
authors.lastname: Nojima
authors.forename: Akio
authors.initials: A
authors.lastname: Kidokoro
mesh_terms: D000077143:Docetaxel; D004304:Dosage Forms; D043823:Taxoids / Q000737:chemistry*; D013997:Time Factors
chemical_list: D004304:Dosage Forms; D043823:Taxoids; D000077143:Docetaxel