title: Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies.
abstract: Proximal renal tubular acidosis (RTA) (Type II RTA) is characterized by a defect in the ability to reabsorb HCO(3) in the proximal tubule. This is usually manifested as bicarbonate wastage in the urine reflecting that the defect in proximal tubular transport is severe enough that the capacity for bicarbonate reabsorption in the thick ascending limb of Henle's loop and more distal nephron segments is overwhelmed. More subtle defects in proximal bicarbonate transport likely go clinically unrecognized owing to compensatory reabsorption of bicarbonate distally. Inherited proximal RTA is more commonly autosomal recessive and has been associated with mutations in the basolateral sodium-bicarbonate cotransporter (NBCe1). Mutations in this transporter lead to reduced activity and/or trafficking, thus disrupting the normal bicarbonate reabsorption process of the proximal tubules. As an isolated defect for bicarbonate transport, proximal RTA is rare and is more often associated with the Fanconi syndrome characterized by urinary wastage of solutes like phosphate, uric acid, glucose, amino acids, low-molecular-weight proteins as well as bicarbonate. A vast array of rare tubular disorders may cause proximal RTA but most commonly it is induced by drugs. With the exception of carbonic anhydrase inhibitors which cause isolated proximal RTA, drug-induced proximal RTA is associated with Fanconi syndrome. Drugs that have been recently recognized to cause severe proximal RTA with Fanconi syndrome include ifosfamide, valproic acid and various antiretrovirals such as Tenofovir particularly when given to human immunodeficiency virus patients receiving concomitantly protease inhibitors such as ritonavir or reverse transcriptase inhibitors such as didanosine.
authors.affiliation: Division of Nephrology/Hypertension, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Syed K
authors.initials: SK
authors.lastname: Haque
authors.forename: Gema
authors.initials: G
authors.lastname: Ariceta
authors.forename: Daniel
authors.initials: D
authors.lastname: Batlle
mesh_terms: D000141:Acidosis, Renal Tubular / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D000818:Animals; D006801:Humans; D009154:Mutation