title: Simulation of the Frank-Starling Law of the Heart.
abstract: We developed a lumped parameter, computer-based model of an equivalent electronic circuit for a one-atrium one-ventricle (frog) heart attached to a vascular circuit, to simulate a basic concept of cardiovascular physiology, the Frank-Starling Law of the Heart. A series of simulations was performed, to observe changes in cardiovascular variables (e.g., arterial pressure, ventricular volume, and valve flows) if either preload or afterload was increased. The simulated data agreed qualitatively, and quantitatively when experimental data are available, with data obtained on amphibian or on mammalian myocardium. In addition, the data obtained in these simulations improve our understanding of the mechanism(s) whereby the heart muscle adapts itself to increased distension (increased preload) or to impeded systolic contraction (increased afterload). The analysis of the measured valve flows suggests that the ventricle is a highly input sensitive pump because the input pressure determines the diastolic distension and, consequently, the force of ventricular systolic contraction. On the other hand, the ventricle is a relatively output insensitive pump. Therefore, not only atrium contraction, but also predominantly the preceding ventricular systolic contraction is the main mechanism of the subsequent diastolic ventricular filling. We conclude that the presented model enables the study of basic concepts of cardiovascular physiology.
authors.affiliation: Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, 1104 Ljubljana, Slovenia. samo.ribaric@mf.uni-lj.si
authors.forename: Samo
authors.initials: S
authors.lastname: Ribarič
authors.forename: Marjan
authors.initials: M
authors.lastname: Kordaš
mesh_terms: D000818:Animals; D062186:Arterial Pressure; D001794:Blood Pressure; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D004594:Electrophysiology / Q000379:methods; D006321:Heart / Q000502:physiology; D006325:Heart Atria / Q000378:metabolism; D006352:Heart Ventricles / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism; D011312:Pressure; D011898:Ranidae