title: Bladder transitional cell carcinoma and BK virus in a young kidney transplant recipient.
abstract: Kidney transplant recipients have a heightened risk of developing neoplasms. Immunosuppressive treatments decrease the incidence of transplant rejection but increase the risk of infections, including BK virus (BKV). This infection is acquired in childhood and remains latent in the renal and urinary epithelium. In cases of immunodeficiency, BKV has been implicated as a tumor virus, but the role of BKV in cancer is a controversial topic and is difficult to determine. In the tumor cells, it is possible to detect fragments of the viral genome that could alter the control mechanisms of the cell cycle and DNA repair. We report the case of a kidney transplant recipient who developed BKV nephropathy and carcinoma of the bladder, supporting a possible role for BKV in the oncogenic pathway in this clinical setting, but the role of BKV in cancer remains a controversial topic and difficult to determine.
authors.affiliation: Department of Urology, Hospital del Mar, Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Pino
authors.forename: E
authors.initials: E
authors.lastname: Rijo
authors.forename: G
authors.initials: G
authors.lastname: Nohales
authors.forename: A
authors.initials: A
authors.lastname: Frances
authors.forename: A
authors.initials: A
authors.lastname: Ubre
authors.forename: O
authors.initials: O
authors.lastname: Arango
mesh_terms: D000328:Adult; D001739:BK Virus / Q000302:isolation & purification*; D002292:Carcinoma, Renal Cell / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology*; D015653:Cystectomy; D006801:Humans; D016867:Immunocompromised Host; D007680:Kidney Neoplasms / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009378:Neoplasms, Multiple Primary; D009894:Opportunistic Infections; D027601:Polyomavirus Infections / Q000209:etiology* / Q000473:pathology; D014412:Tumor Virus Infections / Q000209:etiology* / Q000473:pathology; D014463:Ultrasonography; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology*