title: Emerging techniques in proteomics for probing nano-bio interactions.
abstract: Nanoengineered particles that can facilitate drug formulation and improve specificity of delivery afford exciting opportunities for improved lesion-specific therapy. Understanding and controlling the nano-bio interactions of these materials is central to future developments in this area. Mass-spectrometry-based proteomics techniques, in conjunction with other emerging technologies, are enabling novel insights into the modulation of particle surfaces by biological fluids (formation of the protein corona) and subsequent particle-induced cellular responses. In this Perspective, we summarize important recent developments using proteomics-based techniques to understand nano-bio interactions and discuss the impact of such knowledge on improving particle design.
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.
authors.forename: Zon W
authors.initials: ZW
authors.lastname: Lai
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
authors.forename: Edouard C
authors.initials: EC
authors.lastname: Nice
mesh_terms: D000818:Animals; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D036103:Nanotechnology; D011485:Protein Binding; D040901:Proteomics / Q000379:methods*