title: Predictors of neurocognitive impairment at 3 years after a first episode non-affective psychosis.
abstract: BACKGROUND
  Neurocognitive impairment is a core component of schizophrenia. However, patients show great variability in the level and course of deficits. The goal of the present longitudinal study was to identify predictors of neurocognitive impairment in first episode psychosis patients.
  
  
  METHODS
  Neurocognitive performance was analyzed in a cohort of 146 patients 3 years after a first episode non-affective psychosis. Subgroups, impaired vs. unimpaired, were compared on baseline clinical, neuropsychological, premorbid and sociodemographic characteristics.
  
  
  RESULTS
  Fifty-nine percent of participants presented general neurocognitive impairment and regression analyses demonstrated that clinical and sociodemographic characteristics were not predictive variables. A model composed of premorbid IQ, verbal memory and motor dexterity correctly classified 79.6% of the individuals.
  
  
  CONCLUSIONS
  The present study gives information on frequency and neurocognitive profile of subtypes of patients showing impairment. Our results suggest general neurocognitive impairment is a trait dimension of the disorder related to specific cognitive dysfunctions.
authors.affiliation: Department of Psychiatry, Marqués de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain. rayesa@humv.es
authors.forename: Rosa
authors.initials: R
authors.lastname: Ayesa-Arriola
authors.forename: Rocío
authors.initials: R
authors.lastname: Pérez-Iglesias
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodríguez-Sánchez
authors.forename: Gema
authors.initials: G
authors.lastname: Pardo-García
authors.forename: Rafael
authors.initials: R
authors.lastname: Tabares-Seisdedos
authors.forename: Jose L
authors.initials: JL
authors.lastname: Ayuso-Mateos
authors.forename: Jose L
authors.initials: JL
authors.lastname: Vázquez-Barquero
authors.forename: Benedicto
authors.initials: B
authors.lastname: Crespo-Facorro
mesh_terms: D000293:Adolescent; D000328:Adult; D003072:Cognition Disorders / Q000209:etiology* / Q000523:psychology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007361:Intelligence Tests; D008137:Longitudinal Studies; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications* / Q000523:psychology*; D012044:Regression Analysis; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D012959:Socioeconomic Factors; D014145:Trail Making Test; D014888:Wechsler Scales; D055815:Young Adult