title: [Isonymy analysis in a sample of parents of cystic fibrosis patients from Antioquia, Colombia].
abstract: BACKGROUND
  Cystic fibrosis (CTFR) is one of the most common autosomal recessive disorders in European descendants. Geographic distribution of CFTR gene mutations vary worldwide.
  
  
  OBJECTIVE
  The degree of isonimy was evaluated in a sample of parents with children affected by cystic fibrosis.
  
  
  METHODS
  Observed and expected isonimy as well as endogamy components (Fr, Fn, Ft, and the values α and B) were calculated for 35 parents of children diagnosed with cystic fibrosis. These parameters were calculated for both the total population of Antioquia Province and for an eastern subpopulation of Antioquia.
  
  
  RESULTS
  The values obtained for Fr, Fn, Ft, α and B were 0.01, 0.007, 0.019, 268 and 0.44, respectively for the total population of Antioquia. For the eastern subpopulation, the values were 0.026, 0.0017, 0.027, 135 and 0.62. The most frequent last-names in the total sample (n=70) were Gómez (6%), Alzate (4%), and González (3.7 %), whilst for the eastern subpopulation (n=32) were Gómez (8%) and Marín (6%).
  
  
  CONCLUSIONS
  A high percentage of last-names was shared, as is reflected in the isonimy values. Similarly, the presence of a reduced number of last-names in an important percentage of the population is reflected in the Fr values obtained for both analyses, which suggest homogeneity. Thus, it is expected a low number of CFTR mutations in the children from Antioquia with cystic fibrosis.
authors.affiliation: Grupo Mapeo Genético, Departamento de Pediatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Astrid
authors.initials: A
authors.lastname: Rodríguez-Acevedo
authors.forename: Olga
authors.initials: O
authors.lastname: Morales
authors.forename: Harold
authors.initials: H
authors.lastname: Durango
authors.forename: Nicolás
authors.initials: N
authors.lastname: Pineda-Trujillo
mesh_terms: D000328:Adult; D002648:Child; D003105:Colombia / Q000453:epidemiology; D003241:Consanguinity; D003550:Cystic Fibrosis / Q000453:epidemiology* / Q000235:genetics; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D009275:Names; D010290:Parents; D010375:Pedigree; D014505:Urban Population
chemical_list: C505032:CFTR protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator