title: [Relapsing risk and obstetric-neonatal outcome in pregnancy and systemic lupus erythematosus].
abstract: OBJECTIVE
  to assess the effect of pregnancy on systemic lupus erythematosus (SLE) activity, and the obstetric/neonatal outcome.
  
  
  METHODS
  historic cohort including 24 female SLE patients who became pregnant. For every pregnant/puerperal period, the presence of lupus relapse, mean relapse, Mex-SLEDAI score and prednisone dose were compared.
  
  
  RESULTS
  higher relapse risk (RR = 11.8), more relapse episodes (1.0 ± 1.3 vs. 0.02 ± 0.17), higher Mex-SLEDAI scores (2.0 ± 2.5 vs. 01 ± 0.7) and higher prednisone requirements (13.5 ± 12.6 vs. 7.2 ± 7.5 mg/day), were observed in pregnancy puerperal periods. The abortion incidence: 10.8 %, fetal death: 5.4 %, preeclampsia: 18.8 %, preterm deliveries: 18.9 %, neonatal mortality rate: 6.0 %, perinatal mortality rate: 10.5 %, LES activity associated to obstetric morbidity (83.3 % vs. 38.8 %, p = 0.005), preterm deliveries (43.6 % vs. 11.1 %), neonatal morbidity (46.7 % vs. 11.1 %, and low birth weight (25 % vs. 0).
  
  
  CONCLUSIONS
  lupus pregnancy resulted in higher relapse risk, and more severe LES activity. Lupus activity also worsens obstetric and neonatal outcome.
authors.affiliation: Hospital de Especialidades 1, Instituto Mexicano del Seguro Social, Mérida, Yucatán, Mexico. nemegyei@yahoo.com.mx
authors.forename: José
authors.initials: J
authors.lastname: Alvarez-Nemegyei
authors.forename: Sonia
authors.initials: S
authors.lastname: Domínguez-Vallejo
authors.forename: María Elena
authors.initials: ME
authors.lastname: Saavedra-Déciga
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Marín-Ordóñez
authors.forename: Francisco
authors.initials: F
authors.lastname: Avila-Zapata
authors.forename: Nidia
authors.initials: N
authors.lastname: Diego-Rodríguez
authors.forename: María Teresa de Jesús
authors.initials: MT
authors.lastname: Cervantes-Díaz
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome; D012008:Recurrence; D012307:Risk Factors