title: P27 as a prognostic factor of early cervical carcinoma.
abstract: OBJECTIVE
  The aim of this study was to clarify whether the evaluation of cell-cycle regulatory protein p27 can serve as a prognostic factor in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB cervical carcinoma.
  
  
  METHODS
  A retrospective study was performed on 130 surgically treated patients with FIGO stage IB cervical carcinoma with at least a 5-year follow-up. The expression of p27 was investigated independently by 2 experienced pathologists using immunohistochemistry. The prognostic significance of established prognostic factors and p27 expression were analyzed using univariate and multivariate analyses.
  
  
  RESULTS
  In a univariate analysis, lymph node status, tumor diameter, Gynecologic Oncology Group (GOG) score, lymph vascular space invasion, and p27 expression were significant prognostic factors for overall survival (OS). We found a correlation between p27 expression and lymph node status, tumor diameter, invasion, and GOG score. The p27 expression was a statistically significant prognostic factor for OS in a univariate analysis (log-rank test, P = 0.03). In a multivariate analysis, only lymph node status and tumor diameter were statistically significant prognostic factors for OS.
  
  
  CONCLUSIONS
  This study demonstrated that a low p27 expression is associated with lymph node metastasis, deep stromal invasion, tumor diameter more than 20 mm, and high GOG score and had a prognostic influence on OS in a univariate analysis in a series of 130 women with FIGO stage IB cervical carcinoma. Lymph node status and the diameter of the tumor were the only statistically significant prognostic factors in multivariate analysis.
authors.affiliation: Department of Obstetrics and Gynecology, Medical Faculty Hospital, Charles University, Plzen, Czech Republic. boudaj@medima.cz
authors.forename: Jiri
authors.initials: J
authors.lastname: Bouda
authors.forename: Ondrej
authors.initials: O
authors.lastname: Hes
authors.forename: Miroslava
authors.initials: M
authors.lastname: Koprivova
authors.forename: Martin
authors.initials: M
authors.lastname: Pesek
authors.forename: Tomas
authors.initials: T
authors.lastname: Svoboda
authors.forename: Ludmila
authors.initials: L
authors.lastname: Boudova
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism / Q000502:physiology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism / Q000502:physiology*; D018450:Disease Progression; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D047368:Tumor Burden; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D050760:Cyclin-Dependent Kinase Inhibitor p27