title: Formal synthesis of cephalotaxine.
abstract: A formal synthesis of cephalotaxine, the parent member of the Cephalotaxus alkaloids, was achieved. It features a practical four-step assembly of the benzazepine-bearing pentacyclic ring system through two alkylation reactions, acidic hydrolysis, and aldolization.
authors.affiliation: State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, College of Chemical & Pharmaceutical Engineering, Hebei University of Science & Technology, Shijiazhuang, 050018, China. zhangzw@hebust.edu.cn
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Zhang
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Feng
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Yang
authors.forename: Cui-Cui
authors.initials: CC
authors.lastname: Wang
authors.forename: Jia-Cai
authors.initials: JC
authors.lastname: Feng
authors.forename: Shouxin
authors.initials: S
authors.lastname: Liu
mesh_terms: D000478:Alkylation; D001552:Benzazepines / Q000737:chemistry*; D006248:Harringtonines / Q000138:chemical synthesis*; D000077863:Homoharringtonine; D006868:Hydrolysis; D015394:Molecular Structure
chemical_list: D001552:Benzazepines; D006248:Harringtonines; D000077863:Homoharringtonine