title: 18F-FDG uptake in primary gastric malignant lymphoma correlates with glucose transporter 1 expression and histologic malignant potential.
abstract: Positron emission tomography (PET) is used for staging and response evaluation in primary gastric lymphoma (PGL). However, the implications of [(18)F]-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) uptake in PGL at first diagnosis have not been reported. The relationship between (18)F-FDG uptake and the expression of facilitative glucose transporters (GLUTs), hexokinase II (HK II), and Ki67, as well as malignant potential in PGL, was assessed in this study. We analyzed 23 patients with PGL [nine with diffuse large B-cell lymphoma (DLBCL); seven with high-grade mucosa-associated lymphoid tissue (MALT) lymphoma; and seven with low-grade MALT lymphoma]. The expression levels of GLUT1, GLUT3, HK II, and Ki67 were evaluated according to the percentage of positive area determined by immunohistochemistry. Standardized uptake values correlated significantly with pathological malignant potentials (low-grade/high-grade MALT lymphoma and DLBCL: p = 0.001-0.002), Ki67 (p < 0.001), and GLUT1 expression (p = 0.02). We determined that (18)F-FDG uptake is related to GLUT1 expression and tumor histological grade as well as Ki67 in PGL.
authors.affiliation: Department of Radiology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Suefuji
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hayato
authors.initials: H
authors.lastname: Kaida
authors.forename: Gen
authors.initials: G
authors.lastname: Suzuki
authors.forename: Jun
authors.initials: J
authors.lastname: Uozumi
authors.forename: Etsuyo
authors.initials: E
authors.lastname: Ogo
authors.forename: Mayumi
authors.initials: M
authors.lastname: Miura
authors.forename: Konomi
authors.initials: K
authors.lastname: Takasu
authors.forename: Kanoko
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Keita
authors.initials: K
authors.lastname: Nakahara
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ishibashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Okamura
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Naofumi
authors.initials: N
authors.lastname: Hayabuchi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D005773:Gastroscopy; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D051274:Glucose Transporter Type 3 / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D051272:Glucose Transporter Type 1; D051274:Glucose Transporter Type 3; D019394:Ki-67 Antigen; D019788:Fluorodeoxyglucose F18; D006593:Hexokinase