title: Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells.
abstract: Etoposide (ETP) treatment of ataxia telangiectasia mutated (ATM) and Rad3-related protein (ATR)-, topoisomerase-binding protein-1 (TopBP1) and human MutY homolog (hMYH)-depleted cells results in a significant reduction in apoptotic signaling. The association between ATR or TopBP1 and hMYH increased following ETP treatment. In hMYH knockdown cells, the interaction between ATR and TopBP1 decreased following ETP treatment. We suggest that hMYH functions as a sensor of ETP-induced apoptosis. The results suggest that in the absence of hMYH, cells are unable to recognize the damage signal and the ATR pathway is not activated.
authors.affiliation: Department of Advanced Technology Fusion, Konkuk University, Gwangjin-gu, Seoul 143-701;
authors.forename: Soo-Hyun
authors.initials: SH
authors.lastname: Hahm
authors.forename: Ji Hyung
authors.initials: JH
authors.lastname: Chung
authors.forename: Lia
authors.initials: L
authors.lastname: Agustina
authors.forename: Se-Hee
authors.initials: SH
authors.lastname: Han
authors.forename: In-Soo
authors.initials: IS
authors.lastname: Yoon
authors.forename: Jong-Hwa
authors.initials: JH
authors.lastname: Park
authors.forename: Lin-Woo
authors.initials: LW
authors.lastname: Kang
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Jong Joo
authors.initials: JJ
authors.lastname: Na
authors.forename: Ye Sun
authors.initials: YS
authors.lastname: Han