title: Resistance to two heterologous neurotropic oncolytic viruses, Semliki Forest virus and vaccinia virus, in experimental glioma.
abstract: Attenuated Semliki Forest virus (SFV) may be suitable for targeting malignant glioma due to its natural neurotropism, but its replication in brain tumor cells may be restricted by innate antiviral defenses. We attempted to facilitate SFV replication in glioma cells by combining it with vaccinia virus, which is capable of antagonizing such defenses. Surprisingly, we found parenchymal mouse brain tumors to be refractory to both viruses. Also, vaccinia virus appears to be sensitive to SFV-induced antiviral interference.
authors.affiliation: Centre for Innovative Cancer Therapeutics, Ottawa Health Research Institute, Ottawa, Canada. makoskel@abo.fi
authors.forename: Markus J V
authors.initials: MJ
authors.lastname: Vähä-Koskela
authors.forename: Fabrice
authors.initials: F
authors.lastname: Le Boeuf
authors.forename: Chantal
authors.initials: C
authors.lastname: Lemay
authors.forename: Naomi
authors.initials: N
authors.lastname: De Silva
authors.forename: Jean-Simon
authors.initials: JS
authors.lastname: Diallo
authors.forename: Julie
authors.initials: J
authors.lastname: Cox
authors.forename: Michelle
authors.initials: M
authors.lastname: Becker
authors.forename: Youngmin
authors.initials: Y
authors.lastname: Choi
authors.forename: Abhirami
authors.initials: A
authors.lastname: Ananth
authors.forename: Clara
authors.initials: C
authors.lastname: Sellers
authors.forename: Sophie
authors.initials: S
authors.lastname: Breton
authors.forename: Dominic
authors.initials: D
authors.lastname: Roy
authors.forename: Theresa
authors.initials: T
authors.lastname: Falls
authors.forename: Jan
authors.initials: J
authors.lastname: Brun
authors.forename: Akseli
authors.initials: A
authors.lastname: Hemminki
authors.forename: Ari
authors.initials: A
authors.lastname: Hinkkanen
authors.forename: John C
authors.initials: JC
authors.lastname: Bell
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005910:Glioma / Q000628:therapy*; D051379:Mice; D050504:Oncolytic Viruses / Q000254:growth & development* / Q000276:immunology*; D012672:Semliki forest virus / Q000254:growth & development* / Q000276:immunology*; D014616:Vaccinia virus / Q000254:growth & development* / Q000276:immunology*