title: Evaluation of meloxicam-loaded cationic transfersomes as transdermal drug delivery carriers.
abstract: The aim of this study is to develop meloxicam (MX)-loaded cationic transfersomes as skin delivery carriers and to investigate the influence of formulation factors such as cholesterol and cationic surfactants on the physicochemical properties of transfersomes (i.e., particle size, size distribution, droplet surface charge and morphology), entrapment efficiency, stability of formulations and in vitro skin permeation of MX. The transfersomes displayed a spherical structure. Their size, charge, and entrapment efficiency depended on the composition of cholesterol and cationic surfactants in the formulation. Transfersomes provided greater MX skin permeation than conventional liposomes and MX suspensions. The penetration-enhancing mechanism of skin permeation by the vesicles prepared in this study may be due to the vesicle adsorption to and/or fusion with the stratum corneum. Our results suggest that cationic transfersomes may be promising dermal delivery carriers of MX.
authors.affiliation: Faculty of Pharmacy, Silpakorn University, Sanamchan Palace campus, Nakhon Pathom, 73000, Thailand.
authors.forename: Sureewan
authors.initials: S
authors.lastname: Duangjit
authors.forename: Praneet
authors.initials: P
authors.lastname: Opanasopit
authors.forename: Theerasak
authors.initials: T
authors.lastname: Rojanarata
authors.forename: Tanasait
authors.initials: T
authors.lastname: Ngawhirunpat
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002152:Calorimetry, Differential Scanning; D002412:Cations; D002851:Chromatography, High Pressure Liquid; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D000077239:Meloxicam; D010316:Particle Size; D012867:Skin / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D013843:Thiazines / Q000008:administration & dosage*; D013844:Thiazoles / Q000008:administration & dosage*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002412:Cations; D004337:Drug Carriers; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam