title: Role of melatonin and its receptors in the vertebrate retina.
abstract: Melatonin is a chemical signal of darkness that is produced by retinal photoreceptors and pinealocytes. In the retina, melatonin diffuses from the photoreceptors to bind to specific receptors on a variety of inner retinal neurons to modify their activity. Potential target cells for melatonin in the inner retina are amacrine cells, bipolar cells, horizontal cells, and ganglion cells. Melatonin inhibits the release of dopamine from amacrine cells and increases the light sensitivity of horizontal cells. Melatonin receptor subtypes show differential, cell-specific patterns of expression that are likely to underlie differential functional modulation of specific retinal pathways. Melatonin potentiates rod signals to ON-type bipolar cells, via activation of the melatonin MT2 (Mel1b) receptor, suggesting that melatonin modulates the function of specific retinal circuits based on the differential distribution of its receptors. The selective and differential expression of melatonin receptor subtypes in cone circuits suggest a conserved function for melatonin in enhancing transmission from rods to second-order neurons and thus promote dark adaptation.
authors.affiliation: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. allan-wiechmann@ouhsc.edu
authors.forename: Allan F
authors.initials: AF
authors.lastname: Wiechmann
authors.forename: David M
authors.initials: DM
authors.lastname: Sherry
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D015870:Gene Expression; D006801:Humans; D008550:Melatonin / Q000502:physiology*; D008954:Models, Biological; D018377:Neurotransmitter Agents / Q000378:metabolism; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology; D010802:Phylogeny; D010870:Pineal Gland / Q000502:physiology; D044094:Receptors, Melatonin / Q000235:genetics / Q000502:physiology*; D012160:Retina / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction; D014795:Visual Pathways / Q000166:cytology / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents; D044094:Receptors, Melatonin; D008550:Melatonin