title: A semi-quantitative method for correlating brain disease groups with normal controls using SPECT: Alzheimer's disease versus vascular dementia.
abstract: OBJECTIVE
  To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD).
  
  
  METHODS
  Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis.
  
  
  RESULTS
  AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain.
  
  
  CONCLUSIONS
  Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.
authors.affiliation: University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States. WoodtreeYJ@gmail.com
authors.forename: Yin J
authors.initials: YJ
authors.lastname: Chen
authors.forename: Georg
authors.initials: G
authors.lastname: Deutsch
authors.forename: Ramadass
authors.initials: R
authors.lastname: Satya
authors.forename: Hong-Gang
authors.initials: HG
authors.lastname: Liu
authors.forename: James M
authors.initials: JM
authors.lastname: Mountz
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D015140:Dementia, Vascular / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime