title: The plasma logarithm of the triglyceride/HDL-cholesterol ratio is a predictor of low risk gestational diabetes in early pregnancy.
abstract: BACKGROUND
  The plasma lipid profile changes atherogenically during normal pregnancy. Gestational diabetes mellitus (GDM) can exacerbate the changes in metabolism. The logarithm of the ratio triglycerides/HDL-cholesterol is an atherogenic index of the plasma (AIP) and can be used as a marker for plasma atherogenicity.
  
  
  METHODS
  Serum of 576 unrelated Euro-Brazilian pregnant women was collected and the subjects were classified as healthy pregnant women (control, n=288) and gestational diabetic patients (GDM, n=288) according to the ADA 2010 criteria. Both studied groups were sub classified in 4 gestational periods: (i) 12-23, (ii) 24-28, (iii) 29-32 and (iv) >32 weeks of gestation.
  
  
  RESULTS
  Except for the AIP, the other parameters showed low discrimination between control and GDM groups (ROC curves). When analyzed by ROC curves the AIP of subjects in the early period of gestation showed sensitivity and specificity of 82.6% and 83.4%, respectively, with a cut-off point of 0.099 (AUC 0.886, P<0.0001).
  
  
  CONCLUSIONS
  The AIP is a valuable index to identify pregnant women with low risk of gestational diabetes before 24 weeks of gestation.
authors.affiliation: Department of Medical Pathology, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Izabella C R
authors.initials: IC
authors.lastname: dos Santos-Weiss
authors.forename: Rosângela R
authors.initials: RR
authors.lastname: Réa
authors.forename: Cyntia M T
authors.initials: CM
authors.lastname: Fadel-Picheth
authors.forename: Fabiane G M
authors.initials: FG
authors.lastname: Rego
authors.forename: Fábio de O
authors.initials: Fde O
authors.lastname: Pedrosa
authors.forename: Philippe
authors.initials: P
authors.lastname: Gillery
authors.forename: Emanuel M
authors.initials: EM
authors.lastname: Souza
authors.forename: Geraldo
authors.initials: G
authors.lastname: Picheth
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D012372:ROC Curve; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides