title: Tear osmolarity and ocular surface changes in patient with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate the tear osmolarity and ocular surface changes in patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Forty-eight patients with recently diagnosed PCOS and thirty-three control volunteers were enrolled in this prospective, observational study. Ocular surface disease index (OSDI) score was calculated. Tear osmolarity was measured using the TearLab Osmolarity System (Tearlab, San Diego, CA, USA). All subjects also underwent the following ophthalmologic evaluation: Schirmer I test, tear-film breakup time (TBUT), ocular surface flourescein staining, and conjunctival impression cytology.
  
  
  RESULTS
  Mean OSDI score was significantly higher in patients with PCOS than control subjects (P = 0.001). Tear osmolarity was similar in both groups (P = 0.404). There were no significant differences between groups in Schirmer I test results, TBUT, and ocular surface flourescein staining scores (P > 0.05). Compared to control group, a statistically significant squamous metaplasia was observed in temporal bulbar conjunctival impression cytology specimens in PCOS group (P = 0.032).
  
  
  CONCLUSIONS
  In patients with recently diagnosed PCOS, tear volume and osmolarity are not affected but, conjunctival morphology may be affected, though on a limited scale.
authors.affiliation: Namik Kemal University School of Medicine, Department of Ophthalmology, Tekirdag, Turkey. tansugonen@yahoo.com
authors.forename: Tansu
authors.initials: T
authors.lastname: Gonen
authors.forename: Cem
authors.initials: C
authors.lastname: Celik
authors.forename: Meltem
authors.initials: M
authors.lastname: Oznur
authors.forename: Remzi
authors.initials: R
authors.lastname: Abali
authors.forename: Korcan A
authors.initials: KA
authors.lastname: Gonen
authors.forename: Fatih
authors.initials: F
authors.lastname: Horozoglu
authors.forename: Erson
authors.initials: E
authors.lastname: Aksu
authors.forename: Kadircan H
authors.initials: KH
authors.lastname: Keskinbora
mesh_terms: D000328:Adult; D003229:Conjunctival Diseases / Q000150:complications* / Q000175:diagnosis; D003316:Corneal Diseases / Q000150:complications* / Q000175:diagnosis; D015352:Dry Eye Syndromes / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications; D009994:Osmolar Concentration; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011446:Prospective Studies; D013666:Tears / Q000737:chemistry*; D055815:Young Adult