title: Association between the XRCC3 T241M polymorphism and head and neck cancer susceptibility: a meta-analysis of case-control studies.
abstract: BACKGROUND
  To evaluate the role of the X-ray repair cross complementing group 3 (XRCC3) T241M polymorphism in head and neck cancer susceptibility.
  
  
  METHODS
  We performed a meta-analysis of all available studies, which included 3,191 cases and 5,090 controls.
  
  
  RESULTS
  Overall, a significant risk effect of the T241M polymorphism was not found under homologous contrast (MM vs TT: OR=1.293, 95% CI=0.926-1.805; TM vs TT: OR=1.148 95% CI=0.930-1.418) and recessive models (MM vs TT+TM): OR=1.170, 95% CI=0.905- 1.512, but a significantly increased risk was observed under a dominant model (MM+TM vs TT): OR=1.243, 95% CI=1.001-1.544. In stratified analyses, there were no significant associations for Asians or Caucasians.
  
  
  CONCLUSIONS
  Our meta-analysis suggested the XRCC3 241M allele (MM+TM) might act as a head and neck cancer risk factor among all subjects, and the effect of T241M polymorphism on head and neck susceptibility should be studied with a larger, stratified population.
authors.affiliation: Yueyang Second People's Hospital, Yueyang, China.
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Yin
authors.forename: Chuan
authors.initials: C
authors.lastname: Liu
authors.forename: Lian
authors.initials: L
authors.lastname: Li
authors.forename: Xu-Yu
authors.initials: XY
authors.lastname: Zu
authors.forename: Ya-Jie
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000209:etiology*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3