title: Computational estimation of fluid mechanical benefits from a fluid deflector at the distal end of artificial vascular grafts.
abstract: Intimal hyperplasia at the distal anastomosis is considered to be an important determinant for arterial and arteriovenous graft failure. The connection between unhealthy hemodynamics and intimal hyperplasia motivates the use of computational fluid dynamics modeling to search for improved graft design. However, studies on the fluid mechanical impact on intimal hyperplasia at the suture line intrusion have previously been scanty. In the present work, we focus on intimal hyperplasia at the suture line and illustrate potential benefits from the introduction of a fluid deflector to shield the suture line from unhealthily high wall shear stress.
authors.affiliation: Department of Medical Sciences, Clinical Physiology, Uppsala University, UAS ent 35, S-751 85 Uppsala, Sweden.
authors.forename: M W
authors.initials: MW
authors.lastname: Roos
authors.forename: E
authors.initials: E
authors.lastname: Wadbro
authors.forename: M
authors.initials: M
authors.lastname: Berggren
mesh_terms: D001163:Arteriovenous Anastomosis / Q000503:physiopathology; D001696:Biomechanical Phenomena / Q000502:physiology; D001807:Blood Vessel Prosthesis; D003198:Computer Simulation; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006965:Hyperplasia / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted; D008955:Models, Cardiovascular; D012039:Regional Blood Flow / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013314:Stress, Mechanical; D017539:Tunica Intima / Q000502:physiology; D058017:Vascular Grafting / Q000379:methods*