title: Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system.
abstract: We report on an optical noncontact method for the detection of soft-tissue tumors based on the measurement of their elasticity. A focused air-puff system is used to excite surface waves (SWs) on soft tissues with transient static pressure. A high-speed phase-sensitive optical coherence tomography system is used to measure the SWs as they propagate from the point of excitation. To evaluate the stiffness of soft tissues, the Young's modulus is quantified based on the group velocity of SWs. Pilot experiments were performed on ex vivo human myxoma and normal fat. Results demonstrate the feasibility of the proposed method to measure elasticity and differentiate soft-tissue tumors from normal tissues.
authors.affiliation: Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204-5060, USA.
authors.forename: Shang
authors.initials: S
authors.lastname: Wang
authors.forename: Jiasong
authors.initials: J
authors.lastname: Li
authors.forename: Ravi Kiran
authors.initials: RK
authors.lastname: Manapuram
authors.forename: Floredes M
authors.initials: FM
authors.lastname: Menodiado
authors.forename: Davis R
authors.initials: DR
authors.lastname: Ingram
authors.forename: Michael D
authors.initials: MD
authors.lastname: Twa
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Lazar
authors.forename: Dina C
authors.initials: DC
authors.lastname: Lev
authors.forename: Raphael E
authors.initials: RE
authors.lastname: Pollock
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Larin
mesh_terms: D000388:Air; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006245:Hardness Tests / Q000295:instrumentation; D006801:Humans; D009232:Myxoma / Q000175:diagnosis* / Q000503:physiopathology*; D010812:Physical Stimulation / Q000295:instrumentation*; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000503:physiopathology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*; D014407:Tumor Cells, Cultured