title: Small-world networks in individuals at ultra-high risk for psychosis and first-episode schizophrenia during a working memory task.
abstract: Disturbances of functional interaction between different brain regions have been hypothesized to be the major pathophysiological mechanism underlying the cognitive deficits of schizophrenia. We investigated the small-world functional networks in individuals at ultra-high risk (UHR) for psychosis, first-episode schizophrenia (FESPR) patients, and healthy controls. All participants underwent the electroencephalogram during a control task and a working memory (WM) task. Small-world properties of the theta band were reduced in FESPR relative to controls during the WM task. Small-worldness of the UHR during the WM task exhibited intermediate value between that of controls and FESPR. These results imply that the suboptimal organization of the brain network may play a pivotal role in the schizophrenia pathophysiology.
authors.affiliation: Department of Psychiatry, Konyang University College of Medicine, Daejeon, Republic of Korea.
authors.forename: Kyungun
authors.initials: K
authors.lastname: Jhung
authors.forename: Sung-Hwan
authors.initials: SH
authors.lastname: Cho
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Jang
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Park
authors.forename: Dongkwan
authors.initials: D
authors.lastname: Shin
authors.forename: Kyung Ran
authors.initials: KR
authors.lastname: Kim
authors.forename: Eun
authors.initials: E
authors.lastname: Lee
authors.forename: Kwang-Hyun
authors.initials: KH
authors.lastname: Cho
authors.forename: Suk Kyoon
authors.initials: SK
authors.lastname: An
mesh_terms: D001921:Brain / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D009415:Nerve Net / Q000503:physiopathology*; D011618:Psychotic Disorders / Q000503:physiopathology* / Q000523:psychology; D012306:Risk; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013826:Theta Rhythm; D055815:Young Adult