title: rBiopaxParser--an R package to parse, modify and visualize BioPAX data.
abstract: BACKGROUND
  Biological pathway data, stored in structured databases, is a useful source of knowledge for a wide range of bioinformatics algorithms and tools. The Biological Pathway Exchange (BioPAX) language has been established as a standard to store and annotate pathway information. However, use of these data within statistical analyses can be tedious. On the other hand, the statistical computing environment R has become the standard for bioinformatics analysis of large-scale genomics data. With this package, we hope to enable R users to work with BioPAX data and make use of the always increasing amount of biological pathway knowledge within data analysis methods.
  
  
  RESULTS
  rBiopaxParser is a software package that provides a comprehensive set of functions for parsing, viewing and modifying BioPAX pathway data within R. These functions enable the user to access and modify specific parts of the BioPAX model. Furthermore, it allows to generate and layout regulatory graphs of controlling interactions and to visualize BioPAX pathways.
  
  
  BACKGROUND
  rBiopaxParser is an open-source R package and has been submitted to Bioconductor.
authors.affiliation: Department of Medical Statistics, University Medical Center Göttingen, Humboldtallee 32, Germany. frank.kramer@med.uni-goettingen.de
authors.forename: Frank
authors.initials: F
authors.lastname: Kramer
authors.forename: Michaela
authors.initials: M
authors.lastname: Bayerlová
authors.forename: Florian
authors.initials: F
authors.lastname: Klemm
authors.forename: Annalen
authors.initials: A
authors.lastname: Bleckmann
authors.forename: Tim
authors.initials: T
authors.lastname: Beissbarth
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D003196:Computer Graphics; D016208:Databases, Factual; D023281:Genomics; D008954:Models, Biological; D015398:Signal Transduction; D012984:Software; D018875:Vocabulary, Controlled