title: Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism.
abstract: Recent studies have been raising doubts on the safety of induced pluripotent stem cells (iPSCs) and proposing that the process of reprogramming brought about copy number variations (CNVs) in iPSCs. However, a recent paper published in Nature provided evidence showing that most CNVs were pre-existed as somatic mosaicism but not resulted from the reprogramming. This new finding would profoundly reshape some previous thoughts and endorse the confidence of iPSCs in both research and therapy.
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Wensu
authors.initials: W
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Fei
authors.initials: F
authors.lastname: Yi
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Liu
mesh_terms: D065150:Cellular Reprogramming; D056915:DNA Copy Number Variations; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism*; D009030:Mosaicism; D044968:Regenerative Medicine