title: Changes in depression and quality of life in obese individuals with binge eating disorder: bariatric surgery versus lifestyle modification.
abstract: BACKGROUND
  Obese individuals with binge eating disorder frequently experience impairments in mood and quality of life, which improve with surgical or behavioral weight loss interventions. It is unclear whether these improvements are due to weight loss itself or to additional aspects of treatment, such as group support, or acquisition of cognitive-behavioral skills provided in behavioral interventions. The objective of the study was to compare changes in weight, symptoms of depression, and quality of life in extremely obese individuals with binge eating disorder undergoing bariatric surgery or a lifestyle modification intervention. The study setting was University Hospital.
  
  
  METHODS
  Symptoms of depression and quality of life were assessed at baseline and 2, 6, and 12 months in participants undergoing bariatric surgery but no lifestyle intervention (n = 36) and in nonsurgery participants receiving a comprehensive program of lifestyle modification (n = 49).
  
  
  RESULTS
  Surgery participants lost significantly more weight than lifestyle participants at 2, 6, and 12 months (P<.001). Significant improvements in mood (as measured by the Beck Depression Inventory-II [BDI-II]) and quality of life (as measured by the Short Form-36) were observed in both groups across the year, but there were no differences between the groups at month 12 (even when controlling for reductions in binge eating). A positive correlation was observed between the magnitude of weight loss and change in BDI-II score when collapsing across groups. Moreover, weight loss at one time point predicted BDI-II score at the next time point, but BDI-II score did not predict subsequent weight loss.
  
  
  CONCLUSIONS
  We conclude that similar improvements in mood and quality of life can be expected from either bariatric surgery or lifestyle modification treatments for periods up to 1 year.
authors.affiliation: Perelman School of Medicine at the University of Pennsylvania, Department of Psychiatry, Philadelphia, Pennsylvania. Electronic address: lucyhf@mail.med.upenn.edu.
authors.forename: Lucy F
authors.initials: LF
authors.lastname: Faulconbridge
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Wadden
authors.forename: John G
authors.initials: JG
authors.lastname: Thomas
authors.forename: LaShanda R
authors.initials: LR
authors.lastname: Jones-Corneille
authors.forename: David B
authors.initials: DB
authors.lastname: Sarwer
authors.forename: Anthony N
authors.initials: AN
authors.lastname: Fabricatore
mesh_terms: D000328:Adult; D050110:Bariatric Surgery / Q000523:psychology*; D001521:Behavior Therapy / Q000379:methods*; D056912:Binge-Eating Disorder / Q000523:psychology*; D003863:Depression / Q000523:psychology*; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000523:psychology* / Q000601:surgery / Q000628:therapy; D010147:Pain Measurement; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D015431:Weight Loss