title: How does doxorubicin work?
abstract: A new mechanism involving cleavage of a transcription factor called CREB3L1 has been proposed to explain the anti-tumour effects of doxorubicin.
authors.affiliation: is in the  Department of Molecular Pharmacology and Experimental Therapeutics ,  Mayo Clinic ,  Rochester ,  United States.
authors.forename: Anand G
authors.initials: AG
authors.lastname: Patel
authors.forename: Scott H
authors.initials: SH
authors.lastname: Kaufmann
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000235:genetics*; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics*; D004317:Doxorubicin / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*
chemical_list: D000903:Antibiotics, Antineoplastic; D014408:Biomarkers, Tumor; C485618:CREB3L1 protein, human; D017362:Cyclic AMP Response Element-Binding Protein; D009419:Nerve Tissue Proteins; D004317:Doxorubicin