title: Metabolic effects of honey in type 1 diabetes mellitus: a randomized crossover pilot study.
abstract: The aim of this study was to evaluate the metabolic effects of 12-week honey consumption on patients suffering from type 1 diabetes mellitus (DM). This was a randomized crossover clinical trial done in the National Institute for Diabetes and Endocrinology, Cairo, Egypt. Twenty patients of both sexes aged 4-18 years with type 1 DM and HbA1C<10% participated in the study. They were randomized into two equal groups (intervention to control and control to intervention). The dietary intervention was 12-week honey consumption in a dose of 0.5 mL/kg body weight per day. The main outcome measures were serum glucose, lipids, and C-peptide, and anthropometric measurements. None of participants were lost in follow-up. The intervention resulted in significant decreases in subscapular skin fold thickness (SSFT; P=.002), fasting serum glucose (FSG; P=.001), total cholesterol (P=.0001), serum triglycerides (TG; P=.0001), and low-density lipoprotein (P=.0009), and significant increases in fasting C-peptide (FCP; P=.0004) and 2-h postprandial C-peptide (PCP; P=.002). As possible long-term effects of honey after its withdrawal, statistically significant reductions in midarm circumference (P=.000), triceps skin fold thickness (P=.006), SSFT (P=.003), FSG (P=.005), 2-h postprandial serum glucose (P=.000), TG (P=.003), and HbA1C (P=.043), and significant increases in FCP (P=.002) and PCP (P=.003) were observed. This small clinical trial suggests that long-term consumption of honey might have positive effects on the metabolic derangements of type 1 DM.
authors.affiliation: Faculty of Medicine, Ain Shams University, Cairo, Egypt. mamdouh565@hotmail.com
authors.forename: Mamdouh M
authors.initials: MM
authors.lastname: Abdulrhman
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: El-Hefnawy
authors.forename: Rasha H
authors.initials: RH
authors.lastname: Aly
authors.forename: Rania H
authors.initials: RH
authors.lastname: Shatla
authors.forename: Rasha M
authors.initials: RM
authors.lastname: Mamdouh
authors.forename: Doaa M
authors.initials: DM
authors.lastname: Mahmoud
authors.forename: Waheed S
authors.initials: WS
authors.lastname: Mohamed
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002648:Child; D018592:Cross-Over Studies; D003922:Diabetes Mellitus, Type 1 / Q000178:diet therapy* / Q000378:metabolism*; D005260:Female; D006722:Honey / Q000032:analysis*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000378:metabolism; D008297:Male; D010865:Pilot Projects; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D014280:Triglycerides