title: Diffusion tensor imaging reveals white matter changes associated with cognitive status in patients with Parkinson's disease.
abstract: Objective : Cognitive deficit and white matter alteration relationships in Parkinson's disease (PD) were investigated. Methods : Comparison of 64 patients with PD (M:F, 34:30; 64.4 ± 10.4 years) classified as cognitively normal (PD-CogNL, n = 24), mild cognitive impairment (PD-MCI, n = 30), and dementia (PD-D, n = 10) with 21 healthy participants (M:F, 10:11; 60.1 ± 13.6 years) was conducted using white matter fractional anisotropy (FA), region-of-interest analysis, and diffusion tensor imaging. Results : The PD-D and PD-MCI exhibited higher Unified Parkinson's Disease Rating Scale motor scores (P < .001; P < .01) and Hoehn-Yahr stages (P < .001; P < .05) and FA reductions in left frontal/right temporal white matter and bilateral anterior cingulated bundles. Largest FA reductions occurred in PD-D left anterior cingulated bundle and corpus callosum splenium. Disease durations of PD-D = 6.8 ± 6.86, PD-MCI = 5.1 ± 2.9, and PD-CogNL = 4.7 ± 3.4 years, suggesting progressive deterioration. Conclusions : Cerebral white matter deterioration may underlie progressive cognitive impairment in PD.
authors.affiliation: Department of Neurology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, Guangzhou, China.
authors.forename: Bingmei
authors.initials: B
authors.lastname: Deng
authors.forename: Yuhu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
authors.forename: Kairun
authors.initials: K
authors.lastname: Peng
authors.forename: Lixin
authors.initials: L
authors.lastname: Han
authors.forename: Kun
authors.initials: K
authors.lastname: Nie
authors.forename: Hongjun
authors.initials: H
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000150:complications / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology; D003430:Cross-Sectional Studies; D003704:Dementia / Q000150:complications / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D018450:Disease Progression; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006179:Gyrus Cinguli / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D010300:Parkinson Disease / Q000150:complications / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology