title: Effect of fractionation in stereotactic body radiation therapy using the linear quadratic model.
abstract: OBJECTIVE
  To examine the fractionation effect of stereotactic body radiation therapy with a heterogeneous dose distribution.
  
  
  METHODS
  Derived from the linear quadratic formula with measurements from a hypothetical 2-cm radiosurgical tumor, the threshold percentage was defined as (α/β(tissue)/α/β(tumor)), the balance α/β ratio was defined as (prescription dose/tissue tolerance*α/β(tumor)), and the balance dose was defined as (tissue tolerance/threshold percentage).
  
  
  RESULTS
  With increasing fractions and equivalent peripheral dose to the target, the biological equivalent dose of "hot spots" in a target decreases. The relative biological equivalent doses of serial organs decrease only when the relative percentage of its dose to the prescription dose is above the threshold percentage. The volume of parallel organs at risk decreases only when the tumor's α/β ratio is above the balance α/β ratio and the prescription dose is lower than balance dose.
  
  
  CONCLUSIONS
  The potential benefits of fractionation in stereotactic body radiation therapy depend on the complex interplay between the total dose, α/β ratios, and dose differences between the target and the surrounding normal tissues.
authors.affiliation: Department of Radiation Oncology, Drexel University, Philadelphia, Pennsylvania 19083, USA. JunBME@yahoo.com
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: John
authors.initials: J
authors.lastname: Lamond
authors.forename: Jack
authors.initials: J
authors.lastname: Fowler
authors.forename: Rachelle
authors.initials: R
authors.lastname: Lanciano
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.forename: Luther
authors.initials: L
authors.lastname: Brady
mesh_terms: D000465:Algorithms; D019583:Dose Fractionation, Radiation; D016014:Linear Models; D009369:Neoplasms / Q000601:surgery*; D058958:Organs at Risk / Q000033:anatomy & histology / Q000528:radiation effects*; D011836:Radiation Tolerance / Q000502:physiology / Q000528:radiation effects*; D016634:Radiosurgery / Q000379:methods*; D012062:Relative Biological Effectiveness