title: Mamu-B genes and their allelic repertoires in different populations of Chinese-origin rhesus macaques.
abstract: Since rhesus monkeys of Chinese origin have gained greater utilization in recent years, it is urgent to investigate the major histocompatibility complex (MHC) immunogenetics of Chinese rhesus macaques. In this study, we identified 81 Mamu-B sequences using complementary DNA cloning and sequencing on a cohort of 58 rhesus monkeys derived from three local populations of China. Twenty of these Mamu-B alleles are novel and four of them represent new lineages. Although more alleles are shared among different populations than Mamu-A locus, the Mamu-B allelic repertoires found in these three populations of Chinese macaques are largely independent, which underscores the MHC polymorphism among different populations of Chinese rhesus macaques. Our results are an important addition to the limited MHC immunogenetic information available for rhesus macaques of Chinese origin.
authors.affiliation: Laboratory Animal Center of the Academy of Military Medical Science, Beijing, 100071, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Aixue
authors.initials: A
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Lihua
authors.initials: L
authors.lastname: Sui
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Zeng
authors.forename: Zhaozeng
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000483:Alleles; D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D002681:China; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008253:Macaca mulatta / Q000145:classification* / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D021382:Protein Sorting Signals / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D015395:Histocompatibility Antigens Class I; D021382:Protein Sorting Signals