title: YopM puts caspase-1 on ice.
abstract: Caspase-1-mediated detection of pathogens is a potent arm of the innate immune system. LaRock and Cookson (2012) show that the Yersinia type III secretion effector, YopM, directly inhibits caspase-1.
authors.affiliation: Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Ine
authors.initials: I
authors.lastname: Jørgensen
authors.forename: Edward A
authors.initials: EA
authors.lastname: Miao
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D020170:Caspase 1 / Q000378:metabolism*; D007053:Ice; D058847:Inflammasomes / Q000037:antagonists & inhibitors*; D037521:Virulence Factors / Q000378:metabolism*; D015007:Yersinia; D015010:Yersinia pestis / Q000276:immunology*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D007053:Ice; D058847:Inflammasomes; D037521:Virulence Factors; C060772:yopM protein, Yersinia; D020170:Caspase 1