title: Next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors.
abstract: Genetic studies were performed in a French series of hepatocellular carcinomas. New oncogenes (NFE2L2) and tumor suppressor genes (IRF2, ARID1A and RPS6K3) were found to be recurrently altered. Moreover, a genotoxic signature was identified, raising the possible implication of a genotoxic exposure in the etiology of HCC, which remains to be characterized.
authors.affiliation: Inserm UMR-674; Génomique Fonctionnelle des Tumeurs Solides; IUH; Paris, France ; Université Paris Descartes; Labex Immuno-oncology; Faculté de Médecine; Sorbonne Paris Cité; Paris, France.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Amaddeo
authors.forename: Cécile
authors.initials: C
authors.lastname: Guichard
authors.forename: Sandrine
authors.initials: S
authors.lastname: Imbeaud
authors.forename: Jessica
authors.initials: J
authors.lastname: Zucman-Rossi