title: The HLA-G low expressor genotype is associated with protection against bipolar disorder.
abstract: Implication of immune processes in bipolar disorder (BD) has recently gained increasing attention. Tolerogenic molecules, among which HLA-G plays a prominent role, mediate the modulation of such processes. The HLA-G locus is characterized by a high number of polymorphisms including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele affecting the HLA-G expression. Here, we analyzed the distribution of this polymorphism in 561 BD patients and 161 healthy and found that the HLA-G 14bp Ins/Ins genotype was significantly more prevalent in healthy controls than in patients (corrected p; pc=0.032) and that the prevalence of such protective genotype is lower among patients born during the winter season as compared to those born in other periods (pc=0.006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.
authors.affiliation: INSERM, UMRS 940, Hôpital Saint Louis, Paris, France.
authors.forename: Monojit
authors.initials: M
authors.lastname: Debnath
authors.forename: Marc
authors.initials: M
authors.lastname: Busson
authors.forename: Stéphane
authors.initials: S
authors.lastname: Jamain
authors.forename: Bruno
authors.initials: B
authors.lastname: Etain
authors.forename: Nora
authors.initials: N
authors.lastname: Hamdani
authors.forename: José
authors.initials: J
authors.lastname: Oliveira
authors.forename: Wahid
authors.initials: W
authors.lastname: Boukouaci
authors.forename: Kahina
authors.initials: K
authors.lastname: Amokrane
authors.forename: Hélène
authors.initials: H
authors.lastname: Moins-Teisserenc
authors.forename: Mohamed
authors.initials: M
authors.lastname: Lajnef
authors.forename: Djaouida
authors.initials: D
authors.lastname: Bengoufa
authors.forename: Alain
authors.initials: A
authors.lastname: Malafosse
authors.forename: Frank
authors.initials: F
authors.lastname: Bellivier
authors.forename: Chantal
authors.initials: C
authors.lastname: Henry
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Kahn
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Krishnamoorthy
authors.forename: Dominique
authors.initials: D
authors.lastname: Charron
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
authors.forename: Ryad
authors.initials: R
authors.lastname: Tamouza
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D059951:HLA-G Antigens / Q000235:genetics*; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012621:Seasons; D017384:Sequence Deletion; D055815:Young Adult
chemical_list: D020413:3' Untranslated Regions; D059951:HLA-G Antigens