title: [Alpha-glucosidase inhibitory activity of Aeschynanthus maculatus].
abstract: OBJECTIVE
  To study the inhibitory activity of Aeschynanthus maculatus on alpha-glucosidase.
  
  
  METHODS
  The inhibilitory model of in vitro alpha-glucosidase was established. Active extracts of A. maculatus were isolated and identified bymultiple chromatographic methods, and their molecular structures were identifiied by spectral techniques.
  
  
  RESULTS
  Seven coumpounts were isolated from A. maculatus and isolated as lupeol(1), stigmasterol(2), ursolic acid(3), stigmast-5,22(E)-diene-3beta-ol(4), beta-daucosterol(5), 3-hydroxy-12-taraxasten-28-oic-acid(6) and oleanic acid(7). Compounds 1 (IC50 25.41 mg x L(-1)),3(IC0 4.42 mg L(-1)),4(IC50 11.50 mg x L(-1)),6(IC50 14.17 mg x L(-1)) and 7(IC50 2.88 mg x L(-1)) had higher inhibitory activities than that of acarbose (IC50 1103.01 mg x L(-1)) as the positive control drug.
  
  
  CONCLUSIONS
  Compound 1-7 were isolated from this plant for the first time. Compound 6 was isolated from Gesneriaceae family for the first time. Compound 7 was isolated from Aeschynanthus genus for the first time.
authors.affiliation: Institute of Chinese Medica Materia, He'nan University, Kaifeng 475004, China.
authors.forename: Pu-yu
authors.initials: PY
authors.lastname: Tian
authors.forename: Wen-yi
authors.initials: WY
authors.lastname: Kang
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D029624:Ferns / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D053147:Plant Exudates / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D053147:Plant Exudates