title: Epidemiological study on the incidence of gastroesophageal reflux disease symptoms in patients in acute treatment with NSAIDs.
abstract: Gastroesophageal reflux disease (GERD) is one of the most common disorders in medical practice. The prevalence of GERD in Spain has been reported to be 15%. GERD is associated with esophageal and extra-esophageal complications and with a negative impact on the patients' related quality of life. Several risk factors have been related with the development of GERD, including smoking, coffee intake, alcohol consumption and use of medication, such as NSAIDs. If untreated, GERD symptoms can lead to a decrease of patients' related quality of life and to treatment discontinuation. From this study, it was confirmed that the relationship between GERD and some behavioral risk factors, such as alcohol intake, smoking and coffee consumption, and concomitant treatment with NSAID drugs. Among the protective factors for GERD, antisecretory agents and antacids have shown to be essential for the control of GERD, the use of proton pump inhibitors being the predominant protective factor.
authors.affiliation: Department of Gastroenterology, Hospital Universitario Ramón y Cajal, Carretera Colmenar Viejo, KM 9,100, 28049 Madrid, Spain. carlosmartindeargila@gmail.com
authors.forename: Carlos
authors.initials: C
authors.lastname: Martín-de-Argila
authors.forename: Pedro
authors.initials: P
authors.lastname: Martínez-Jiménez
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology; D000863:Antacids / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D016009:Chi-Square Distribution; D003069:Coffee / Q000009:adverse effects; D003430:Cross-Sectional Studies; D005260:Female; D005764:Gastroesophageal Reflux / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D008019:Life Style; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D013030:Spain / Q000453:epidemiology
chemical_list: D000863:Antacids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003069:Coffee; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors