title: [A histological response to antiviral therapy for chronic hepatitis C in patients who failed to achieve a sustained virological response].
abstract: The paper presents the results of combination antiviral therapy (AVT) in 2 patients with chronic hepatitis C (CHC) unresponsive to AVT. Both patients are classified as difficult to treat (genotype 1b, a high viral load, overweight). 1.5 years after the termination of a course of AVT, histological examination of biopsy specimens revealed a histological response in one patient and significant histological worsening in the other. The specific features of the development of a histological response to AVT and possible reasons for its lack are discussed by the example of the described patients.
authors.forename: A M
authors.initials: AM
authors.lastname: Ryumin
authors.forename: O V
authors.initials: OV
authors.lastname: Korochkina
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001706:Biopsy; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D050177:Overweight; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D000998:Antiviral Agents