title: BST-2/tetherin: structural biology, viral antagonism, and immunobiology of a potent host antiviral factor.
abstract: BST-2 (also known as tetherin, CD317, or HM1.24) was first described as a potent interferon-inducible host antiviral factor nearly five years ago. Since that time, numerous reports have been published regarding the antiviral activity and immunological properties of this protein. BST-2 blocks viral replication by inhibiting enveloped virus budding from the surface of infected cells. To counteract this, most viruses have developed strategies to antagonize BST-2, each employing a unique mechanism. In this review, we summarize the antiviral function, structural biology and immunobiology of BST-2. Taken together, our current understanding of BST-2 suggests potential avenues as well as challenges to exploiting its action in the development of broad spectrum antiviral treatments.
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, United States.
authors.forename: Melissa
authors.initials: M
authors.lastname: Swiecki
authors.forename: Natalie S
authors.initials: NS
authors.lastname: Omattage
authors.forename: Tom J
authors.initials: TJ
authors.lastname: Brett
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D058851:GPI-Linked Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D057074:Virus Release
chemical_list: D000998:Antiviral Agents; D058851:GPI-Linked Proteins