title: Risk-adapted chemotherapy without procarbazine in treatment of children with Hodgkin lymphoma.
abstract: BACKGROUND
  Because procarbazine is not available in the mainland of China, a risk-adapted chemotherapy without the drug was adopted for children with Hodgkin lymphoma (HL) in two tertiary referral centers for childhood cancer in Shanghai. The objective of the present study was to obtain the results comparable with those of previous studies.
  
  
  METHODS
  From January 1998 to December 2009, patients below 18 years with newly diagnosed, untreated HL were enrolled in the study. The patients were stratified into risk groups R1 (early stage), R2 (intermediate stage) and R3 (advanced stage). All the patients who had attained a complete remission were not given involved field radiotherapy.
  
  
  RESULTS
  Fifty-six patients were eligible for the study. The 4-year event-free survival (EFS) rate was 100%, 80.3%±7.2%, and 62.5%±12.1% for the risk groups R1, R2, and R3, respectively. There was statistically significant difference in EFS between patients with and those without B symptoms (P<0.001). In group R2, the EFS rate was higher for patients treated with chemotherapy combined with radiation (100% vs. 75%±8.8%). But no statistical difference was observed (P=0.177). At the time of evaluation (December 31, 2010), secondary malignancy was not observed.
  
  
  CONCLUSIONS
  A significant fraction of children with early stage or intermediate stage HL can be cured with a chemotherapy regimen without procarbazine. Complete response to chemotherapy seems not to be a determinant to omit radiotherapy.
authors.affiliation: Children's Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Yi-Jin
authors.initials: YJ
authors.lastname: Gao
authors.forename: Jing-Yan
authors.initials: JY
authors.lastname: Tang
authors.forename: Ci
authors.initials: C
authors.lastname: Pan
authors.forename: Feng-Juan
authors.initials: FJ
authors.lastname: Lu
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Xue
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011344:Procarbazine; D012189:Retrospective Studies; D012306:Risk
chemical_list: D000970:Antineoplastic Agents; D011344:Procarbazine