title: Theranostics meets traditional Chinese medicine: rational prediction of drug-herb interactions.
abstract: Herbal medicines including traditional Chinese medicine are becoming increasingly more popular worldwide. However, there is considerable potential for interaction between herbal components and drugs, as all herbal medicines contain a combination of potentially biologically active compounds possessing various inherent pharmacological activities, and the components of herbal products consumed are eliminated from the body by the same mechanisms that remove drugs. Indeed, many so-called conventional drugs are derived from plant sources. This article provides an update on the mechanisms and evidence of drug-herb interactions (DHIs) and genetic influences on DHIs. The rational prediction of clinically important DHIs is also discussed. Individualized and targeted drug therapy could be achieved by identifying the population most likely to be helped or harmed by drug-herb coadministration.
authors.affiliation: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Hu
authors.forename: Lan
authors.initials: L
authors.lastname: Fan
authors.forename: Hong-Hao
authors.initials: HH
authors.lastname: Zhou
authors.forename: Brian
authors.initials: B
authors.lastname: Tomlinson
mesh_terms: D019380:Anti-HIV Agents / Q000493:pharmacokinetics; D000925:Anticoagulants / Q000493:pharmacokinetics; D000928:Antidepressive Agents / Q000493:pharmacokinetics; D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D019937:Diagnostic Techniques and Procedures; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics; D057890:Epigenomics; D023281:Genomics; D041743:Herb-Drug Interactions / Q000235:genetics*; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics; D008516:Medicine, Chinese Traditional / Q000379:methods*; D010597:Pharmacogenetics; D010975:Platelet Aggregation Inhibitors / Q000493:pharmacokinetics; D011110:Polymorphism, Genetic; D040901:Proteomics; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013812:Therapeutics / Q000379:methods*
chemical_list: D019380:Anti-HIV Agents; D000925:Anticoagulants; D000928:Antidepressive Agents; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D010975:Platelet Aggregation Inhibitors