title: Long-term supplementation of high pigmented rice bran oil (Oryza sativa L.) on amelioration of oxidative stress and histological changes in streptozotocin-induced diabetic rats fed a high fat diet; Riceberry bran oil.
abstract: Diabetes is a serious health problem. Searching for alternative natural antioxidants is considered important strategy to manage diabetes. This study evaluated the effect of Riceberry bran oil (RBBO) supplementation on oxidative stress and organ histology in streptozotocin-induced diabetic rats fed a high fat (HF) diet. Adult male Sprague-Dawley rats with hyperglycemia were divided into four groups: DM group fed a HF diet alone; DMRL group fed a HF diet and 5% RBBO; DMRM group fed a HF diet and 7.5% RBBO; DMRH group fed a HF diet and 15% RBBO. Normal rats were used as normal control and were divided into NC and NR group fed a normal diet containing either 5% corn oil or 5% RBBO, respectively. After 12 weeks, RBBO significantly decreased malondialdehyde and restored superoxide dismutase, catalase, glutathione peroxidase, coenzyme Q(10) and ORAC levels in diabetic rats. RBBO additionally improved the regenerative changes of the pancreas, kidneys, heart and liver. These findings indicate that pigmented RBBO could provide beneficial effect on diabetes by decreasing oxidative stress and recovering organ histology.
authors.affiliation: Institute of Nutrition, Mahidol University, Phutthamonthon 4, Nakhon Pathom 73170, Thailand.
authors.forename: Juthathip
authors.initials: J
authors.lastname: Posuwan
authors.forename: Pattaneeya
authors.initials: P
authors.lastname: Prangthip
authors.forename: Vijittra
authors.initials: V
authors.lastname: Leardkamolkarn
authors.forename: Uruwan
authors.initials: U
authors.lastname: Yamborisut
authors.forename: Ruethaithip
authors.initials: R
authors.lastname: Surasiang
authors.forename: Rin
authors.initials: R
authors.lastname: Charoensiri
authors.forename: Ratchanee
authors.initials: R
authors.lastname: Kongkachuichai
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy* / Q000201:enzymology / Q000209:etiology / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D019587:Dietary Supplements / Q000032:analysis*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D012275:Oryza / Q000737:chemistry*; D018384:Oxidative Stress / Q000187:drug effects*; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010938:Plant Oils / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000073879:Rice Bran Oil; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D010938:Plant Oils; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D000073879:Rice Bran Oil