title: Biocatalysts for multicomponent Biginelli reaction: bovine serum albumin triggered waste-free synthesis of 3,4-dihydropyrimidin-2-(1H)-ones.
abstract: Bovine serum albumin (BSA) promoted simple and efficient one-pot procedure was developed for the direct synthesis of 3,4-dihydropyrimidin-2(1H)-ones including potent mitotic kinesin Eg5 inhibitor monastrol under mild reaction conditions. The catalyst recyclability and gram scale synthesis have also been demonstrated to enhance the practical utility of process.
authors.affiliation: Natural Plant Products Division, CSIR-Institute of Himalayan Bioresource Technology (Council of Scientific and Industrial Research), Palampur 176061, H.P., India.
authors.forename: Upendra K
authors.initials: UK
authors.lastname: Sharma
authors.forename: Nandini
authors.initials: N
authors.lastname: Sharma
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Arun K
authors.initials: AK
authors.lastname: Sinha
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002417:Cattle; D060326:Chemistry Techniques, Synthetic; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry; D055772:Green Chemistry Technology; D008049:Lipase / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D001688:Biological Products; D004095:Dihydropyridines; D012710:Serum Albumin, Bovine; D008049:Lipase