title: Antibiotic prophylaxis for bilateral sagittal split osteotomies: a randomized, double-blind clinical study.
abstract: The goal of this study was to determine the efficacy of one dose and a short course (3 doses) of amoxycillin therapy for the prevention of infection following bilateral sagittal split osteotomy (BSSO). Patients who qualified for the trial were randomly divided into two groups: group I patients were given a single injection of amoxycillin 1.0 g administered preoperatively followed by two postoperative doses of saline four hourly (single dose group); group II patients were given single injection amoxycillin 1.0 g administered preoperatively followed by two postoperative doses of amoxycillin 0.5 g four hourly. The 60 patients included in this study were divided into two groups of 30. The patients were evaluated for 2 months for postoperative infections. In the postoperative period, six patients required rescue antibiotics in the single dose group and one in the short course group (P=0.04). There was a statistical difference in the rates of infection between the two groups (P=0.04). The findings indicate that a short postoperative course of antibiotics is more effective than a single preoperative dose for the prevention of infection following BSSO.
authors.affiliation: Saveetha Dental College and Hospitals, 162, Poonamalle High Road, Velappanchavadi, Chennai 600077, Tamil Nadu, India. docwahab@hotmail.com
authors.forename: P U A
authors.initials: PU
authors.lastname: Wahab
authors.forename: V
authors.initials: V
authors.lastname: Narayanan
authors.forename: S
authors.initials: S
authors.lastname: Nathan
authors.lastname: Madhulaxmi
mesh_terms: D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D059229:Osteotomy, Sagittal Split Ramus / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin