title: Pregnancy outcomes and relative risk factors among Chinese women with congenital heart disease.
abstract: OBJECTIVE
  To summarize pregnancy outcomes among a cohort of Chinese women with congenital heart disease (CHD) and to identify predictive risk factors for maternal, fetal, and neonatal complications.
  
  
  METHODS
  A retrospective analysis of 529 women with CHD who gave birth at the Shanghai Obstetrical Cardiology Intensive Care Center, Shanghai, China, between January 1, 1993, and September 30, 2010. Maternal, fetal, and neonatal complications were evaluated for these women.
  
  
  RESULTS
  Maternal cardiac complications were reported in 33 (6.2%) of the women, whereas fetal and neonatal complications were reported in 145 (27.4%). The factors found to be significantly predictive for maternal cardiac complications were cardiac events before pregnancy (odds ratio [OR] 36.811), New York Heart Association functional class greater than II (OR 27.702), oxygen saturation below 90% (OR 7.506), and left ventricular obstruction (aorta stenosis) (OR 2.408). Factors significantly predictive for fetal and neonatal complications were New York Heart Association functional class greater than II (OR 20.12), oxygen saturation below 90% (OR 3.78), and pulmonary arterial hypertension (systolic pressure ≥ 50 mm Hg) (OR 3.42).
  
  
  CONCLUSIONS
  Identification of maternal, fetal, and neonatal complications among women with CHD may guide medical intervention and therefore reduce pregnancy-associated risk for these patients.
authors.affiliation: Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.forename: Taotao
authors.initials: T
authors.lastname: Huang
authors.forename: Weixiu
authors.initials: W
authors.lastname: Zhao
authors.forename: Yao
authors.initials: Y
authors.lastname: Shen
authors.forename: Jianhua
authors.initials: J
authors.lastname: Lin
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology* / Q000209:etiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult