title: Outcome of intestinal transplants for patients with Crohn's disease.
abstract: BACKGROUND
  The pathophysiology of Crohn's disease (CD) is related to immune dysregulation making it unique among indications for intestinal transplants (ITx). We examined whether outcomes of ITx for CD are any worse than the overall ITx population.
  
  
  METHODS
  United Network for Organ Sharing Standard Transplant Analysis and Research files were analyzed. Adult ITx recipients from 1987 to 2009 were included.
  
  
  RESULTS
  Of 86 primary ITx for CD, 61 (70%) had isolated ITx and 25 (30%) had liver-ITx (L-ITx). The 1-, 3-, and 5-year patient survival for isolated ITx was 85%, 67%, and 54%; for L-ITx, 63%, 47%, and 41% (P = .04). The graft survival at 1, 3, and 5 years was 85%, 55%, and 45% for isolated ITx recipients and 63%, 47%, and 41% for L-ITx recipients (Wilcoxon's test, P = .04). Patient and graft survival was better in era 2 (January 2001 through August 2009) than in era 1 (October 1987 through December 2000). In the regression analysis of long-term outcome of adults undergoing ITx, recipient age > 40 years and hospitalization prior to transplantation were negative predictors of outcome.
  
  
  CONCLUSIONS
  Patient and graft survival for CD patients is not inferior to other indications for ITx.
authors.affiliation: Georgetown Transplant Institute, Washington, D.C., USA. Electronic address: csdesai@gmail.com.
authors.forename: C S
authors.initials: CS
authors.lastname: Desai
authors.forename: K
authors.initials: K
authors.lastname: Khan
authors.forename: A
authors.initials: A
authors.lastname: Gruessner
authors.forename: R
authors.initials: R
authors.lastname: Gruessner
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000601:surgery*; D005260:Female; D006801:Humans; D007422:Intestines / Q000637:transplantation*; D008297:Male; D017063:Outcome Assessment, Health Care