title: CT coronary angiography: coronary CT-flow quantification supplements morphological stenosis analysis.
abstract: BACKGROUND
  Our rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic (CT) changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying the significance and hemodynamic relevance of a stenosis and thereby supplement as a functional parameter for morphological stenosis analysis.
  
  
  METHODS
  A total of 50 patients prospectively underwent computed tomography coronary angiography (coronary CTA) in a multidetector CT scanner (Brilliance 64, Philips)±1 day before or after invasive coronary angiography (ICA). Immediately thereafter, 2 radiologists reviewed the imaging data to detect any vessel segments with morphology poorly evaluable by coronary CTA. A locally constant cyclical measurement was acquired in these coronary arteries in breath-hold technique during the passage of a 50ml bolus of contrast media. For analysis, time-density curves of the bolus passage were registered in the coronary artery and the aorta (internal reference), the up-slopes were determined and correlated with each other. The results were compared with the ICA findings.
  
  
  RESULTS
  47 of 50 CT flow measurements were evaluable. A good correlation was found between the degrees of stenosis and slope ratios in aorta and coronary artery (R(2)=0.92). The threshold corridor was 0.55-0.77 for distinguishing hemodynamically (≥70%) from non-hemodynamically relevant stenoses.
  
  
  CONCLUSIONS
  CT-based coronary artery flow measurements (CTFM) correlate well with the angiographically determined degree of stenosis and can elevate by non-invasive means the diagnostic accuracy of coronary CTA. From both a clinically diagnostic and scientific standpoint, CTFM proves a suitable method for quantifying coronary blood flow.
authors.affiliation: Institute and Policlinic of Radiological Diagnostics, University of Cologne, 50924 Cologne, Germany. henning.bovenschulte@uk-koeln.de
authors.forename: H
authors.initials: H
authors.lastname: Bovenschulte
authors.forename: B
authors.initials: B
authors.lastname: Krug
authors.forename: T
authors.initials: T
authors.lastname: Schneider
authors.forename: H
authors.initials: H
authors.lastname: Schwabe
authors.forename: C
authors.initials: C
authors.lastname: Kabbasch
authors.forename: C
authors.initials: C
authors.lastname: Bangard
authors.forename: M
authors.initials: M
authors.lastname: Hellmich
authors.forename: G
authors.initials: G
authors.lastname: Michels
authors.forename: D
authors.initials: D
authors.lastname: Maintz
authors.forename: K
authors.initials: K
authors.lastname: Lackner
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007479:Iopamidol / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol