title: Distinctive personality traits and neural correlates associated with stimulant drug use versus familial risk of stimulant dependence.
abstract: BACKGROUND
  Stimulant drugs such as cocaine and amphetamine have a high abuse liability, but not everyone who uses them develops dependence. However, the risk for dependence is increased for individuals with a family history of addiction. We hypothesized that individuals without a family history of dependence who have been using cocaine recreationally for several years but have not made the transition to dependence will differ in terms of personality traits and brain structure from individuals who are either dependent on stimulants or at risk for dependence.
  
  
  METHODS
  We compared 27 individuals without a familial risk of dependence who had been using cocaine recreationally with 50 adults with stimulant dependence, their nondependent siblings (n = 50), and unrelated healthy volunteers (n = 52) who had neither a personal nor a family history of dependence. All participants underwent a magnetic resonance imaging brain scan and completed a selection of personality measures that have been associated with substance abuse.
  
  
  RESULTS
  Increased sensation-seeking traits and abnormal orbitofrontal and parahippocampal volume were shared by individuals who were dependent on stimulant drugs or used cocaine recreationally. By contrast, increased levels of impulsive and compulsive personality traits and limbic-striatal enlargement were shared by stimulant-dependent individuals and their unaffected siblings.
  
  
  CONCLUSIONS
  We provide evidence for distinct neurobiological phenotypes that are either associated with familial vulnerability for dependence or with regular stimulant drug use. Our findings further suggest that some individuals with high sensation-seeking traits but no familial vulnerability for dependence are likely to use cocaine but may have relatively low risk for developing dependence.
authors.affiliation: University of Cambridge, Behavioural and Clinical Neuroscience Institute, Departments of Experimental Psychology and Psychiatry, Cambridge, United Kingdom. ke220@cam.ac.uk
authors.forename: Karen D
authors.initials: KD
authors.lastname: Ersche
authors.forename: P Simon
authors.initials: PS
authors.lastname: Jones
authors.forename: Guy B
authors.initials: GB
authors.lastname: Williams
authors.forename: Dana G
authors.initials: DG
authors.lastname: Smith
authors.forename: Edward T
authors.initials: ET
authors.lastname: Bullmore
authors.forename: Trevor W
authors.initials: TW
authors.lastname: Robbins
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D019970:Cocaine-Related Disorders / Q000473:pathology* / Q000523:psychology*; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D010551:Personality; D012307:Risk Factors