title: Isolation and characterization of three fungi with the potential of transforming glycyrrhizin.
abstract: Three fungi with different types of transformation of glycyrrhizin (GL) were isolated from the soil samples of glycyrrhiza glabra planting area in China. According to their morphologies and 18 S rDNA gene sequence analysis, the three fungi were identified and named as Penicillium purpurogenum Li-3, Aspergillus terreus Li-20 and Aspergillus ustus Li-62. Transforming products analysis by TLC and HPLC-MS indicated that P. purpurogenum Li-3, A. terreus Li-20 and A. ustus Li-62 could stably transform GL into GAMG, GAMG and GA, and GA, respectively. P. purpurogenum Li-3 was especially valuable to directly prepare GAMG for applications in the pharmaceutical industry.
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Guo
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Qi
authors.forename: Shi-Jiang
authors.initials: SJ
authors.lastname: Feng
authors.forename: Chun
authors.initials: C
authors.lastname: Li
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Zhou
mesh_terms: D001230:Aspergillus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D001711:Biotransformation; D002681:China; D006035:Glycyrrhiza / Q000254:growth & development / Q000382:microbiology; D019695:Glycyrrhizic Acid / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010407:Penicillium / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D010802:Phylogeny; D012988:Soil Microbiology
chemical_list: D019695:Glycyrrhizic Acid