title: The investigation of the interaction between Oxymetazoline hydrochloride and mucin by spectroscopic approaches.
abstract: The fluorescence and ultraviolet spectroscopy were explored to study the interaction between Oxymetazoline hydrochloride (OMZH) and mucin under imitated physiological condition. The results demonstrated that the fluorescence quenching mechanism between OMZH and mucin is a combined quenching process. The binding constants (K(a)), binding sites (n) and the corresponding thermodynamic parameters (ΔG, ΔH, and ΔS) of the interaction system were calculated at different temperatures. The hydrogen bonds and van der Waals forces play a major role in the interaction between OMZH and mucin. According to Förster non-radiation energy transfer theory, the binding distance between OMZH and mucin was calculated.
authors.affiliation: Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China. yu_xianyong@163.com
authors.forename: Xianyong
authors.initials: X
authors.lastname: Yu
authors.forename: Heting
authors.initials: H
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Shiyu
authors.initials: S
authors.lastname: Lu
authors.forename: Qin
authors.initials: Q
authors.lastname: Yao
authors.forename: Pinggui
authors.initials: P
authors.lastname: Yi
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D009077:Mucins / Q000737:chemistry / Q000378:metabolism*; D014663:Nasal Decongestants / Q000737:chemistry / Q000378:metabolism*; D010109:Oxymetazoline / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
chemical_list: D000316:Adrenergic alpha-Agonists; D009077:Mucins; D014663:Nasal Decongestants; D010109:Oxymetazoline