title: Modulation of drug release by utilizing pH-independent matrix system comprising water soluble drug verapamil hydrochloride.
abstract: The present study was undertaken to investigate the effect of hydrophilic, plastic and hydrophobic types of polymers and  their  content  level  on  the  release profile of drug from matrix systems. To improve therapeutic efficacy, systemic absorption and patient compliance a sustained release matrix tablets of Verapamil HCl (VHE) has been developed. VHE tablets were prepared by using various polymers like hydrophilic (HPMC K15M CR), plastic (Kollidon SR), hydrophobic (Eudragit RSPO) and combination of best two resulted polymers using direct compression. A 32 full factorial design was applied to study the effect of polymers on drug release. For the combination of polymers, selected factors HPMC K15 CR (X(1)) and Eudragit RSPO (X(2)) showed positive influence on drug release at 18 hrs and 20 hrs. The release profile of VHE formulation exhibits Higuchi model with anomalous diffusion release. Accelerated stability trials for 3 months proved reproducibility. A good correlation between the dissolution profiles and bioavailability indicated a linear relationship between in vitro - in vivo data. The current study attained the successful design, development and optimization of controlled release once-a-day formulation of VHE.
authors.affiliation: Institute of Pharmaceutical Education, Boradi, Tal-Shirpur, Dist-Dhule, India. baviskar@sancharnet.in
authors.forename: Dheeraj
authors.initials: D
authors.lastname: Baviskar
authors.forename: Rajesh
authors.initials: R
authors.lastname: Sharma
authors.forename: Dinesh
authors.initials: D
authors.lastname: Jain
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D065347:Hypromellose Derivatives; D007700:Kinetics; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D008956:Models, Chemical; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods; D014700:Verapamil / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction; D055815:Young Adult
chemical_list: D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D004337:Drug Carriers; C496966:Eudragit RSPO; D011108:Polymers; D011109:Polymethacrylic Acids; D013607:Tablets; D014867:Water; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D014700:Verapamil; D011205:Povidone