title: Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection.
abstract: A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne Parkville, VIC, Australia.
authors.forename: Brendan E
authors.initials: BE
authors.lastname: Russ
authors.forename: Alice E
authors.initials: AE
authors.lastname: Denton
authors.forename: Lauren
authors.initials: L
authors.lastname: Hatton
authors.forename: Hayley
authors.initials: H
authors.lastname: Croom
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Olson
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Turner