title: Discovery of nosokophic acid, a predicted intermediate of moenomycins, from nosokomycin-producing Streptomyces sp. K04-0144.
abstract: A new actinomycete metabolite designated nosokophic acid was isolated from the culture broth of nosokomycin-producing Streptomyces sp. K04-0144, and the structure was elucidated by various NMR experiments. Nosokophic acid was found to be 3-phosphoglycosyl-2-sesquiterpenyl dihydroxypropionic acid, a predicted biosynthetic intermediate of nosokomycin-related moenomycins. The compound showed no activity against MRSA, but potentiated imipenem activity against MRSA by 512-fold.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Tokyo 108-8641, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Koyama
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Tokura
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001455:Bambermycins / Q000737:chemistry / Q000378:metabolism*; D055808:Drug Discovery; D004357:Drug Synergism; D006603:Hexuronic Acids / Q000737:chemistry* / Q000494:pharmacology; D015378:Imipenem / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010755:Organophosphates / Q000737:chemistry* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*
chemical_list: C581852:3-phosphoglycosyl-2-sesquiterpenyl dihydroxypropionic acid; D000900:Anti-Bacterial Agents; D006603:Hexuronic Acids; D010755:Organophosphates; D001455:Bambermycins; D015378:Imipenem