title: Results of transoral laser microsurgery in 102 patients with squamous cell carcinoma of the tonsil.
abstract: The objective of this study is to assess the feasibility of transoral laser microsurgery (TLM) in the treatment of squamous cell cancer of the tonsil and to report the oncological and functional outcomes, using retrospective chart review in the setting of single-institute, academic tertiary referral center. Between October 1987 and December 2006, 102 patients were eligible for this study, mostly suffering from advanced disease: 13% presented with stage I and II (UICC/AJCC 2002) tumors and 87% with stages III and IVa. The median follow-up was 63 months. All patients were treated by TLM with (or without) neck dissection (95%) and with (66%) postoperative radiotherapy. Overall survival, recurrence-free survival, disease-free survival, local control and loco-regional control were analyzed as end points. Rate of tracheotomies, postoperative complications and swallowing function were also analyzed. 5-year Kaplan-Meier local and loco-regional control was 78% for pT1 and pT2 and 75 % for pT3 and pT4a tumors. 5-year Kaplan-Meier disease-free survival, recurrence-free survival, and overall survival and was 74, 64 and 59% for stage I and II, 68, 60 and 56 % for stage III and IVa, respectively. Our data supports the conclusion, that TLM should be considered as a therapeutic option for the treatment of cancer of the tonsil. The oncological and functional results are comparable to any other treatment regimen, while the morbidity and complications tend to be lower.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Göttingen, Robert-Koch-Str 40, 37099 Göttingen, Germany. martin.canis@med.uni-goettingen.de
authors.forename: Martin
authors.initials: M
authors.lastname: Canis
authors.forename: Alexios
authors.initials: A
authors.lastname: Martin
authors.forename: Martina
authors.initials: M
authors.lastname: Kron
authors.forename: Alexandra
authors.initials: A
authors.lastname: Konstantinou
authors.forename: Friedrich
authors.initials: F
authors.lastname: Ihler
authors.forename: Hendrik A
authors.initials: HA
authors.lastname: Wolff
authors.forename: Christoph
authors.initials: C
authors.lastname: Matthias
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Steiner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D009367:Neoplasm Staging; D014066:Palatine Tonsil / Q000473:pathology / Q000601:surgery*; D010610:Pharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome