title: Nationwide surveillance in uterine cancer: survival analysis and the importance of birth cohort: 30-year population-based registry in Taiwan.
abstract: BACKGROUND
  Uterine cancer was the most rapidly increasing malignancy and the second most common gynecologic malignancy in Taiwan.
  
  
  METHODS
  We analyzed the secular trend of uterine cancer incidence and compare the survival of women with uterine carcinomas and uterine sarcomas in Taiwan. Data on women diagnosed with uterine cancer between 1979 and 2008 were obtained from the Taiwan cancer registry. Survival data were analyzed by using Kaplan-Meier and Cox proportional hazards regression methods.
  
  
  RESULTS
  Records of 11,558 women with uterine carcinomas and 1,226 women with uterine sarcomas were analyzed. The age-adjusted incidence rate of endometrioid adenocarcinoma increased from 0.83 per 100,000 women per year between 1979 and 1983 to 7.50 per 100,000 women per year between 2004 and 2008. The 5-year survival rate of women with endometrioid adenocarcinoma (83.2%) was higher than that for women with clear cell carcinoma (58.3%), serous carcinoma (54.4%), and carcinosarcoma (35.2%) (p<0.0001, log-rank test). The 5-year survival rates of women with low grade endometrial stromal sarcoma, endometrial stromal sarcoma, leiomyosarcoma (LMS), and adenosarcoma were 97.5%, 73.5%, 60.1%, and 77.2%, respectively (p<0.0001, log rank test). The histologic type of endometrioid adenocarcinoma, young age, and treatment period after 2000 were independent, favorable prognostic factors in women with uterine carcinomas by multivariate analysis. The histologic type of LMS, old age, and treatment period after 2000 were independent, poor prognostic factors in women with uterine sarcomas by multivariate analysis.
  
  
  CONCLUSIONS
  An increase over time in the number of patients with endometrioid adenocarcinomas was noted in this 30-year, nationwide, population-based study. Histologic type, age and treatment period were survival factors for uterine cancers. A more comprehensive assessment of uterine cancers and patient care should be undertaken on this increasingly common type of cancer.
authors.affiliation: Gynecologic Cancer Center, Cathay General Hospital, Taipei, Taiwan.
authors.forename: Chia-Yen
authors.initials: CY
authors.lastname: Huang
authors.forename: Chi-An
authors.initials: CA
authors.lastname: Chen
authors.forename: Yu-Li
authors.initials: YL
authors.lastname: Chen
authors.forename: Chun-Ju
authors.initials: CJ
authors.lastname: Chiang
authors.forename: Tsui-Hsia
authors.initials: TH
authors.lastname: Hsu
authors.forename: Ming-Chieh
authors.initials: MC
authors.lastname: Lin
authors.forename: Mei-Shu
authors.initials: MS
authors.lastname: Lai
authors.forename: Chien-Jen
authors.initials: CJ
authors.lastname: Chen
authors.forename: San-Lin
authors.initials: SL
authors.lastname: You
authors.forename: Wen-Fang
authors.initials: WF
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002277:Carcinoma / Q000453:epidemiology* / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011159:Population Surveillance; D012042:Registries; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology* / Q000503:physiopathology