title: [Predicting value of serum CEA and CA19-9 in neoadjuvant chemotherapy for advanced gastric carcinoma].
abstract: OBJECTIVE
  To investigate the predictive value of CEA and CA19-9 in tumor progression, prognosis and neoadjuvant chemotherapy of advanced gastric cancer.
  
  
  METHODS
  Clinical data of 322 patients with advanced gastric cancer(54 cases undergoing neoadjuvant chemotherapy) from the Affiliated Oncologic Hospital of Guangzhou Medical College were reviewed. Serum CEA and CA19-9 levels were detected by electrochemiluminescence immunoassay, while the expression of CEA and CA19-9 protein in 54 pairs of tumor tissues and matched biopsies neoadjuvant chemotherapy were determined by immunohistochemistry.
  
  
  RESULTS
  The expression levels of serum CEA and CA19-9 were closely related to tumor invasion, lymph node metastasis and TNM stage(all P<0.05). The 5-year cumulative survival rates of patients with serum CEA-positive and CA19-9-positive were 17.0% and 11.9%, compared with 34.6% and 34.8% of the patients with serum CEA-negative and CA19-9-negative respectively (both P<0.05). Neoadjuvant chemotherapy could down-regulate CEA and CA19-9 expressions in tumor tissues(P<0.05), while there was no significantly difference in serum level(P>0.05).
  
  
  CONCLUSIONS
  The expressions of serum CEA and CA19-9 are closely associated with tumor progression and prognosis in advanced gastric cancer. However, further study should be done to evaluate their value in selecting patients to receive neoadjuvant chemotherapy.
authors.affiliation: Department of Abdominal Surgery, Guangzhou Medical College, Guangzhou, China. hongjian1012@hotmail.com
authors.forename: Jia-hong
authors.initials: JH
authors.lastname: Wang
authors.forename: Cong
authors.initials: C
authors.lastname: Mai
authors.forename: Jian
authors.initials: J
authors.lastname: Hong
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.forename: Hong-sheng
authors.initials: HS
authors.lastname: Tang
authors.forename: Yun-qiang
authors.initials: YQ
authors.lastname: Tang
authors.forename: Shu-zhong
authors.initials: SZ
authors.lastname: Cui
mesh_terms: D018395:CA-19-9 Antigen / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000628:therapy; D015996:Survival Rate
chemical_list: D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen