title: Anti‑obesity effects of Actinidia polygama extract in mice with high‑fat diet‑induced obesity.
abstract: Actinidia polygama has been used as a herbal folk medicine for treating pain, gout, rheumatoid arthritis and inflammation. In the present study, the anti‑obesity properties of Actinidia polygama extract (APE) were investigated in mice with high‑fat diet‑induced obesity. APE treatment of high‑fat diet (HFD)‑fed obese mice significantly reduced body weight, adipose tissue mass and serum triglyceride and leptin levels relative to the HFD‑fed mice. Food intake did not differ between the HFD and HFD+APE groups, although the food efficiency ratio (FER) was significantly decreased in the HFD+APE group compared with the HFD group. Histological examination showed that the sizes of the adipocytes were significantly smaller in the HFD+APE group compared with the HFD group. Serum levels of aspartate transaminase were significantly decreased in the HFD+APE mice compared with the HFD‑fed mice, but serum levels of alanine transaminase (ALT), blood urea nitrogen and creatinine were not significantly changed in the HFD+APE mice compared with the levels in the normal diet (ND)‑fed and HFD‑fed mice. These results suggest that APE may be useful for treating metabolic diseases, including obesity and hyperlipidemia, without toxic side‑effects.
authors.affiliation: Basic Herbal Medicine Research Group, Korea Institute of Oriental                     Medicine, Daejeon 305‑811, Republic of Korea.
authors.forename: Yoon-Young
authors.initials: YY
authors.lastname: Sung
authors.forename: Taesook
authors.initials: T
authors.lastname: Yoon
authors.forename: Won-Kyung
authors.initials: WK
authors.lastname: Yang
authors.forename: Byeong-Cheol
authors.initials: BC
authors.lastname: Moon
authors.forename: Ho Kyoung
authors.initials: HK
authors.lastname: Kim
mesh_terms: D029042:Actinidia / Q000737:chemistry*; D000273:Adipose Tissue / Q000187:drug effects / Q000473:pathology; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D048429:Cell Size; D003404:Creatinine / Q000097:blood; D059305:Diet, High-Fat; D004435:Eating / Q000187:drug effects; D020738:Leptin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D019440:Anti-Obesity Agents; D020738:Leptin; D010936:Plant Extracts; D014280:Triglycerides; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase