title: Association of candidate gene polymorphisms with diastolic blood pressure change in patients treated with duloxetine.
abstract: Single nucleotide polymorphisms in six genes were investigated for an association between diastolic blood pressure change and duloxetine treatment. Nominally significant within-gene association was found with SLC6A2 rs4436775 and rs4564560 and HTR2A rs6313, but after adjusting for multiple comparisons, these associations were no longer significant.
authors.affiliation: Global Statistics and Advanced Analytics, Lilly USA, LLC, Mail Code 4103, Indianapolis, IN, USA. fijal_bonnie_ann@lilly.com
authors.forename: Bonnie Ann
authors.initials: BA
authors.lastname: Fijal
authors.forename: Jared
authors.initials: J
authors.lastname: Kohler
authors.forename: Katherine
authors.initials: K
authors.lastname: Ostbye
authors.forename: Jonna
authors.initials: J
authors.lastname: Ahl
authors.forename: John Phillip
authors.initials: JP
authors.lastname: Houston
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects* / Q000235:genetics; D002394:Catechol O-Methyltransferase / Q000235:genetics; D003865:Major Depressive Disorder / Q000188:drug therapy; D003971:Diastole / Q000187:drug effects / Q000235:genetics; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics; D010146:Pain / Q000188:drug therapy; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D011954:Receptors, Dopamine / Q000235:genetics; D011985:Receptors, Serotonin / Q000235:genetics; D013876:Thiophenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: C553443:ADRB2 protein, human; D018759:Adrenergic Uptake Inhibitors; D050484:Norepinephrine Plasma Membrane Transport Proteins; D018343:Receptors, Adrenergic, beta-2; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; C493227:SLC6A2 protein, human; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride; D002394:Catechol O-Methyltransferase