title: [Children with obesity and declining linear growth curve: Cushing's disease?].
abstract: We describe two children who presented with extreme weight gain and failure to grow in height, and who were both diagnosed with Cushing's disease. Following preoperative metyrapone treatment, both children successfully underwent curative transsphenoidal surgery. While obesity is a common and increasing problem in childhood, Cushing's disease is rare. The combination of weight gain and growth failure in a child is an alarming sign in which underlying endocrine disease must be ruled out.
authors.affiliation: Emma Kinderziekenhuis AMC, Afd. Kinderendocrinologie, Amsterdam, the Netherlands.
authors.forename: Esther M
authors.initials: EM
authors.lastname: van Wezel
authors.forename: Hanneke M
authors.initials: HM
authors.lastname: van Santen
authors.forename: Wouter  R
authors.initials: W
authors.lastname: van Furth
authors.forename: Liesbeth
authors.initials: L
authors.lastname: Reneman
authors.forename: Peter H
authors.initials: PH
authors.lastname: Bisschop
authors.forename: A S Paul
authors.initials: AS
authors.lastname: van Trotsenburg
mesh_terms: D000236:Adenoma / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D001827:Body Height / Q000502:physiology*; D002648:Child; D003480:Cushing Syndrome / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D003907:Dexamethasone; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009765:Obesity / Q000175:diagnosis*; D010911:Pituitary Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D003907:Dexamethasone