title: Estimation of salivary nitric oxide in recurrent aphthous ulcer and oral lichen planus patients with its clinical significance.
abstract: OBJECTIVE
  The present study was undertaken to study the role of nitric oxide in human saliva and its diagnostic/prognostic role in recurrent aphthous ulcers (RAU) and oral lichen planus (OLP).
  
  
  METHODS
  The study was carried out at outpatient department of Govt Dental College and Hospital, Aurangabad. Twenty cases with RAU, 15 with OLP and 30 healthy individuals were included in the study. The clinically diagnosed known cases of RAU and OLP were included after taking the detail case history and subjected to blood analysis for hemogram and biochemically salivary nitric oxide was estimated.
  
  
  RESULTS
  The salivary nitric oxide levels were found to be increased significantly in RAU and OLP group, when compared with controls. Further, significantly increased levels have been observed in OLP group, when compared with RAU group (p < 0.001). The salivary nitric oxide levels were found to be increased significantly in minor RAU than major RAU and increased in erosive type of OLP than nonerosive type of OLP.
  
  
  CONCLUSIONS
  Thus, salivary nitric oxide can be treated as a diagnostic tool for the differential diagnosis of RAU and OLP.
  
  
  CONCLUSIONS
  Nitric oxide plays an important role in modifying physiopathological processes of oral mucosal membrane so has diagnostic as well as prognostic value.
authors.affiliation: Department of Oral Pathology and Microbiology, Yashwantrao Chavan Dental College, Ahmednagar, Maharashtra, India. dr_kiranjagtap@rediffmail.com
authors.forename: Kiran
authors.initials: K
authors.lastname: Jagtap
authors.forename: R K
authors.initials: RK
authors.lastname: Baad
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005609:Free Radicals / Q000032:analysis; D006801:Humans; D017676:Lichen Planus, Oral / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000032:analysis*; D011379:Prognosis; D012463:Saliva / Q000737:chemistry*; D013281:Stomatitis, Aphthous / Q000188:drug therapy / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005609:Free Radicals; D009569:Nitric Oxide