title: Prevalence of parvovirus B 19 infection in children with aplastic anemia.
abstract: We studied the prevalence of parvovirus B19 infection in pediatric patients with acquired aplastic anemia. Detection of parvovirus B19 DNA by PCR and IgM antibodies by ELISA was carried out in 66 pediatric patients with acquired aplastic anemia. 45 healthy children acted as controls. Parvovirus B19 DNA was detected in significantly higher number of patients in comparison to controls (27% vs 2%, P = 0.001). Similarly, parvovirus B19 IgM antibodies were detected in 17 (25.8%) patients as against one control (2.2%) (P<0.05). Clinical and hematological profile of the patients with or without parvovirus infection was comparable.
authors.affiliation: Departments of Pediatrics and *Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
authors.forename: Vineeta
authors.initials: V
authors.lastname: Gupta
authors.forename: Isha
authors.initials: I
authors.lastname: Saini
authors.forename: Gopal
authors.initials: G
authors.lastname: Nath
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000453:epidemiology / Q000821:virology*; D000914:Antibodies, Viral / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D010322:Parvoviridae Infections / Q000097:blood* / Q000453:epidemiology / Q000821:virology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000302:isolation & purification*; D015995:Prevalence
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral