title: Heart type fatty acid binding protein response and subsequent development of atherosclerosis in insulin resistant polycystic ovary syndrome patients.
abstract: BACKGROUND
  Women with polycystic ovary syndrome (PCOS) have higher risk for cardiovascular disease (CVD). Heart type fatty acid binding protein (HFABP) has been found to be predictive for myocardial ischemia.Wet ested whether HFABP is the predictor for CVD in PCOS patients, who have an increased risk of cardiovascular disease.
  
  
  METHODS
  This was a prospective, cross sectional controlled study conducted in a training and research hospital.The study population consisted of 46 reproductive-age PCOS women and 28 control subjects. We evaluated anthropometric and metabolic parameters, carotid intima media thickness and HFABP levels in both PCOS patients and control group.
  
  
  RESULTS
  Mean fasting insulin, homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride, total cholesterol, low density lipoprotein cholesterol, free testosterone, total testosterone, carotid intima media thickness (CIMT) levels were significantly higher in PCOS patients. Although HFABP levels were higher in PCOS patients, the difference did not reach statistically significant in early age groups. After adjustment for age and body mass index, HFABP level was positive correlated with hsCRP, free testosterone levels, CIMT and HOMA-IR.
  
  
  CONCLUSIONS
  Heart type free fatty acid binding protein appeared to have an important role in metabolic response and subsequent development of atherosclerosis in insulin resistant, hyperandrogenemic PCOS patients.
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Diskapi Training and Research Hospital, Ankara, Turkey. mustafaozbek10@hotmail.com.
authors.forename: Evrim
authors.initials: E
authors.lastname: Cakir
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozbek
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.forename: Erman
authors.initials: E
authors.lastname: Cakal
authors.forename: Askin
authors.initials: A
authors.lastname: Gungunes
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ginis
authors.forename: Taner
authors.initials: T
authors.lastname: Demirci
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibasi