title: Successful treatment of epilepsy by resection of periventricular nodular heterotopia.
abstract: We report on a case of successful surgical treatment of drug-resistant epilepsy associated with a solitary lesion of periventricular nodular heterotopia (PNH). In the reported patient, intracranial ictal electroencephalography disclosed that seizures did not originate from the heterotopic nodules. However, the seizures were completely suppressed by lesionectomy of PNH alone. Epileptogenesis associated with PNH likely involves a very complex network between PNH and the surrounding cortex, and the disruption of this network may be an effective means of curing intractable, PNH-associated epilepsy.
authors.affiliation: Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. garit@cc.okayama-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Agari
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Mihara
authors.forename: Koichi
authors.initials: K
authors.lastname: Baba
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Naotaka
authors.initials: N
authors.lastname: Usui
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Terada
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Nakamura
authors.forename: Kazumi
authors.initials: K
authors.lastname: Matsuda
authors.forename: Isao
authors.initials: I
authors.lastname: Date
mesh_terms: D000328:Adult; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D054091:Periventricular Nodular Heterotopia / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome