title: Is there still a role for autologous stem cell transplantation in acute myeloid leukemia?
abstract: BACKGROUND
  the role of autologous stem cell transplantation (ASCT) in treatment of acute myeloid leukemia (AML) remains unsettled.
  
  
  OBJECTIVE
  retrospective analysis to evaluate the role of ASCT in patients with AML without HLA-matched donor.
  
  
  METHODS
  between December 19, 1994 and August 1, 2012, a total of 63 patients with AML without HLA-matched donor in the department of Hematology and Transfusion Medicine, University Hospital, Bratislava, received an ASCT. Median age was 41 years (20-61 years). There were 35 (56%) males and 28 (44%) females. At the time of ASCT, 50 (79%) patients were in first complete remission (CR), 11 (18%) patients were in second CR and 2 (3%) patients were in relapse.
  
  
  RESULTS
  with a median follow-up of 115 months (34-214 months), the 10 year overall survival (OS) and disease free survival (DFS) of all patients was 55% and 51%, respectively. Transplant-related mortality was 6%. The relapse rate was 38% and 9 years probability of relapse was 44%.
  
  
  CONCLUSIONS
  ASCT is still an effective post-remission treatment in AML patients without HLA-matched donor; with the possibility of long-term survival or even cure in remarkable proportion of patients with AML, particularly in patients with favorable and intermediate cytogenetic risk. .
authors.affiliation: Department of Hematology and Transfusion Medicine, University Hospital, Bratislava, Slovakia. alsabty@pe.unb.sk
authors.forename: F A
authors.initials: FA
authors.lastname: Sabty
authors.forename: E
authors.initials: E
authors.lastname: Demeckova
authors.forename: E
authors.initials: E
authors.lastname: Bojtarova
authors.forename: M
authors.initials: M
authors.lastname: Hrubisko
authors.forename: M
authors.initials: M
authors.lastname: Mistrik
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D014182:Transplantation, Autologous