title: SREBP: a novel therapeutic target.
abstract: Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the biosynthesis of cholesterol, fatty acid, and triglyceride. They control the expression of crucial genes involved in lipogenesis and uptake. In this review, we summarize the processing of SREBPs and their regulation by insulin, cAMP, and vitamin A, and the relationship between miRNA and lipid metabolism. We also discuss the recent functional studies on SREBPs. These discoveries suggest that inhibition of SREBP can be a novel strategy to treat metabolic diseases, such as type II diabetes, insulin resistance, fatty liver, and atherosclerosis.
authors.affiliation: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shangha, China. xiaxu@sibcb.ac.cn
authors.forename: Xu
authors.initials: X
authors.lastname: Xiao
authors.forename: Bao-Liang
authors.initials: BL
authors.lastname: Song
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000502:physiology; D050356:Lipid Metabolism; D008659:Metabolic Diseases / Q000628:therapy; D012333:RNA, Messenger / Q000235:genetics; D051779:Sterol Regulatory Element Binding Proteins / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D014801:Vitamin A / Q000502:physiology
chemical_list: D007328:Insulin; D012333:RNA, Messenger; D051779:Sterol Regulatory Element Binding Proteins; D014801:Vitamin A; D000242:Cyclic AMP