title: Copper-boosting compounds: a novel concept for antimycobacterial drug discovery.
abstract: We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against replicating and nonreplicating M. tuberculosis strains.
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Speer
authors.forename: Tej B
authors.initials: TB
authors.lastname: Shrestha
authors.forename: Stefan H
authors.initials: SH
authors.lastname: Bossmann
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Basaraba
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Harber
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Michalek
authors.forename: Michael
authors.initials: M
authors.lastname: Niederweis
authors.forename: Olaf
authors.initials: O
authors.lastname: Kutsch
authors.forename: Frank
authors.initials: F
authors.lastname: Wolschendorf
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D015195:Drug Design; D057166:High-Throughput Screening Assays / Q000379:methods*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000472:pathogenicity; D010618:Phenanthrolines / Q000494:pharmacology; D014131:Trace Elements / Q000494:pharmacology; D014376:Tuberculosis; D037521:Virulence Factors
chemical_list: D000995:Antitubercular Agents; D010618:Phenanthrolines; D014131:Trace Elements; D037521:Virulence Factors; D003300:Copper; C002701:neocuproine; C002478:bathocuproine