title: Antimicrobial evaluation of some novel derivatives of 3,4-dihydropyrimidine-2(1H)-one.
abstract: The antimicrobial activity of thirty six novel dihydropyrimidine derivatives was evaluated against common pathogenic bacteria. Significant antimicrobial activity (MIC=32, 64 μg/ml) was observed. Escherichia coli and Pseudomonas aeruginosa as Gram-negative bacteria and Staphylococcus aureus as Gram-positive bacteria were determined to be the most susceptible pathogens in this study. The highest inhibitory activity was observed against Gram-negative microorganisms. The widest spectrum of antibacterial activity was exerted by C6 and C22. Most of the compounds had remarkable antifungal activity (MIC=32 μg/ml).
authors.affiliation: Food Security Research Center and School of Food Science Nutrition and, Isfahan University of Medical Sciences, Isfahan, I.R. Iran .
authors.forename: M
authors.initials: M
authors.lastname: Jalali
authors.forename: M
authors.initials: M
authors.lastname: Mahdavi
authors.forename: H R
authors.initials: HR
authors.lastname: Memarian
authors.forename: M
authors.initials: M
authors.lastname: Ranjbar
authors.forename: M
authors.initials: M
authors.lastname: Soleymani
authors.forename: A
authors.initials: A
authors.lastname: Fassihi
authors.forename: D
authors.initials: D
authors.lastname: Abedi