title: The basic science and clinical applications of osteochondral allografts.
abstract: Indications for the use of osteochondral allografts for orthopaedic surgical applications are increasing with improved  surgical techniques and advancing experience. Modern  tissue banks have developed harvesting, processing, and  storage methods that ensure an adequate, safe supply of  grafts. Continued research is necessary to find a technique  that maximizes chondrocyte viability and metabolism both  during storage and implantation. The majority of published  data on the use of osteochondral allografts has focused on  the management of osteochondral defects about the knee.  Successful outcomes following these procedures have led  to increased interest in their application to pathology affecting other joints including the shoulder and ankle. The  current paper aims to review the basic science and clinical  applications of osteochondral allografts.
authors.affiliation: Division of Sports Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Strauss
authors.forename: Robert
authors.initials: R
authors.lastname: Sershon
authors.forename: Joseph U
authors.initials: JU
authors.lastname: Barker
authors.forename: James
authors.initials: J
authors.lastname: Kercher
authors.forename: Michael
authors.initials: M
authors.lastname: Salata
authors.forename: Nikhil N
authors.initials: NN
authors.lastname: Verma
mesh_terms: D000818:Animals; D000843:Ankle Joint / Q000473:pathology / Q000601:surgery; D016025:Bone Transplantation / Q000009:adverse effects; D002358:Cartilage, Articular / Q000601:surgery*; D006085:Graft Survival; D006801:Humans; D007719:Knee Joint / Q000473:pathology / Q000601:surgery; D019637:Orthopedic Procedures / Q000009:adverse effects; D012785:Shoulder Joint / Q000473:pathology / Q000601:surgery; D014015:Tissue Banks; D014021:Tissue Preservation; D020858:Tissue and Organ Harvesting; D014184:Transplantation, Homologous; D016896:Treatment Outcome