title: Effect of inorganic salts on the clouding behavior of hydroxypropyl methyl cellulose in presence of amphiphilic drugs.
abstract: In this paper we report the effect of two cationic (imipramine hydrochloride (IMP) and promazine hydrochloride (PMZ)) and one anionic (sodium salt of ibuprofen (IBF)) drugs on the clouding behavior of a nonionic polymer hydroxypropyl methyl cellulose (HPMC). Though all the three drugs increase the cloud point (CP) of HPMC, the effect was found to be minimum in the case of IBF. Further, the effect of adding salts (NaF, NaCl, NaBr, NaNO(3), Na(2)SO(4), Na(3)PO(4), KCl, KBr, KNO(3)) in the presence of amphiphilic drugs (IMP and PMZ) on the CP of HPMC was seen. Almost linear decrease in the CP was observed with the [salt] at fixed concentrations of these drugs whereas in the absence of drugs the decrement in the CP was slight. The energetic parameters (ΔG(c)(0), ΔH(c)(0) and TΔS(c)(0)) were evaluated and it implies that the disruption of water structure becomes significantly prominent at lower concentrations of the drugs at fixed salt concentrations.
authors.affiliation: Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, India. driqrarakhan@gmail.com
authors.forename: Iqrar Ahmad
authors.initials: IA
authors.lastname: Khan
authors.forename: Kahkashan
authors.initials: K
authors.lastname: Anjum
authors.forename: P Ajmal
authors.initials: PA
authors.lastname: Koya
authors.lastname: Kabir-Ud-Din
mesh_terms: D000838:Anions; D065347:Hypromellose Derivatives; D007052:Ibuprofen / Q000737:chemistry; D007099:Imipramine / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D008823:Micelles; D008958:Models, Molecular; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011395:Promazine / Q000737:chemistry; D012492:Salts / Q000737:chemistry*; D012996:Solutions; D013501:Surface-Active Agents / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D000838:Anions; D008823:Micelles; D004364:Pharmaceutical Preparations; D012492:Salts; D012996:Solutions; D013501:Surface-Active Agents; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D011395:Promazine; D007099:Imipramine; D007052:Ibuprofen