title: LDL cholesterol-lowering effects of grape extract used as a dietary supplement on healthy volunteers.
abstract: The aim of this study was to evaluate the effects of Eminol®, the polyphenol-rich grape extract supplement (700 mg), on cardiovascular risk and oxidant stress indicators in a sample of volunteers. A randomized, double-blind, placebo-controlled clinical trial was performed over 56 days and included 60 volunteers. Thirty volunteers took 700 mg of the grape extract, Eminol® (E), and 30 took the placebo (P). On comparison of the results, a decrease in total cholesterol (E: 213.77 ± 4.1 mg/dl and P: 245.57 ± 4.1 mg/dl; p = 0.01) and LDL cholesterol (E: 142.17 ± 3.1 mg/dl and P: 165.13 ± 3.1 mg/dl; p = 0.02) levels as well as an increase in antioxidant capacity (E: 65.63 ± 5.8 μmol TE/mg and P: 57.80 ± 7.7 μmol TE/mg; p < 0.01) and vitamin E (E: 11.46 ± 0.5 μg/ml and P: 9.06 ± 0.5 μg/ml; p = 0.018) was observed. This result indicates that the grape extract Eminol® modulated the lipid profile in terms of cardiovascular risk indicators, lowering total blood cholesterol and LDL cholesterol levels.
authors.affiliation: Research and Development Department, Esdor Cosméticos, Valladolid, Spain. imasd@esdor.es
authors.forename: Noemí
authors.initials: N
authors.lastname: Yubero
authors.forename: Marisa
authors.initials: M
authors.lastname: Sanz-Buenhombre
authors.forename: Alberto
authors.initials: A
authors.lastname: Guadarrama
authors.forename: Sonia
authors.initials: S
authors.lastname: Villanueva
authors.forename: Juan M
authors.initials: JM
authors.lastname: Carrión
authors.forename: Eider
authors.initials: E
authors.lastname: Larrarte
authors.forename: Carlos
authors.initials: C
authors.lastname: Moro
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D059808:Polyphenols / Q000494:pharmacology*; D012016:Reference Values; D014810:Vitamin E / Q000097:blood; D027843:Vitis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D008078:Cholesterol, LDL; D010936:Plant Extracts; D059808:Polyphenols; D014810:Vitamin E; D002784:Cholesterol