title: Diffusion tensor imaging patterns differ in bulbar and limb onset amyotrophic lateral sclerosis.
abstract: BACKGROUND
  Amyotrophic lateral sclerosis (ALS) is characterized by pronounced clinical heterogeneity in terms of onset and disease progression. Widespread changes in white matter fibres could be observed by diffusion tensor imaging (DTI), which detects alterations in the degree (diffusivity, ADC) and directedness (fractional anisotropy, FA) of proton movement. The aim of the current study was to determine whether different ALS onset types were reflected in different DTI brain patterns.
  
  
  METHODS
  Seventeen patients with a diagnosis of ALS (6 bulbar, 11 limb onset) and seventeen age-matched controls received 1.5T DTI, where FA and ADC were analyzed using statistical parametric mapping.
  
  
  RESULTS
  In ALS patients, an increased diffusivity in the white matter was found below the precentral gyrus and along the corticospinal tract (CST) right into the internal capsule. The FA was decreased in the posterior limb of internal capsule and in the subcortical white matter in the precentral gyrus. In bulbar onset increased diffusivity was found in the CST, whilst in limb onset, frontal subcortical areas displayed an increased diffusivity.
  
  
  CONCLUSIONS
  DTI changes can be regarded as prominent features in ALS. Herein we were able to demonstrate discriminating brain DTI patterns due to bulbar or limb onset.
authors.affiliation: Hans-Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. tino.prell@med.uni-jena.de
authors.forename: Tino
authors.initials: T
authors.lastname: Prell
authors.forename: Thomas
authors.initials: T
authors.lastname: Peschel
authors.forename: Viktor
authors.initials: V
authors.lastname: Hartung
authors.forename: Joern
authors.initials: J
authors.lastname: Kaufmann
authors.forename: Ribanna
authors.initials: R
authors.lastname: Klauschies
authors.forename: Nils
authors.initials: N
authors.lastname: Bodammer
authors.forename: Katja
authors.initials: K
authors.lastname: Kollewe
authors.forename: Reinhard
authors.initials: R
authors.lastname: Dengler
authors.forename: Julian
authors.initials: J
authors.lastname: Grosskreutz
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology*; D016880:Anisotropy; D015415:Biomarkers; D001931:Brain Mapping; D003627:Data Interpretation, Statistical; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005121:Extremities / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D020772:Internal Capsule / Q000473:pathology; D035002:Lower Extremity / Q000473:pathology; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D009460:Neurologic Examination; D011712:Pyramidal Tracts / Q000473:pathology; D013131:Spine / Q000473:pathology*; D034941:Upper Extremity / Q000473:pathology
chemical_list: D015415:Biomarkers