title: The systems containing clays and clay minerals from modified drug release: a review.
abstract: Clays are materials commonly used in the pharmaceutical industry, either as ingredients or as active ingredients. It was observed that when they are administered concurrently, they may interact with drugs reducing their absorption. Therefore, such interactions can be used to achieve technological and biopharmaceutical advantages, regarding the control of release. This review summarizes bibliographic (articles) and technological (patents) information on the use of systems containing clays and clay minerals in modified drug delivery. In this area, formulations such natural clay, commercial clay, synthetic clay, composites clay-polymers, nanocomposites clay-polymers, films and hidrogels composites clay-polymers are used to slow/extend or vectorize the release of drugs and consequently they increase their bioavailability. Finally, this review summarizes the fields of technology and biopharmaceutical applications, where clays are applied.
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal do Piauí, Teresina, PI, CEP 64049-550, Brazil.
authors.forename: Luís Alberto de Sousa
authors.initials: LA
authors.lastname: Rodrigues
authors.forename: Ana
authors.initials: A
authors.lastname: Figueiras
authors.forename: Francisco
authors.initials: F
authors.lastname: Veiga
authors.forename: Rivelilson Mendes
authors.initials: RM
authors.lastname: de Freitas
authors.forename: Lívio César Cunha
authors.initials: LC
authors.lastname: Nunes
authors.forename: Edson Cavalcanti
authors.initials: EC
authors.lastname: da Silva Filho
authors.forename: Cleide Maria
authors.initials: CM
authors.lastname: da Silva Leite
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D000077215:Clay; D016503:Drug Delivery Systems; D008903:Minerals / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry; D010330:Patents as Topic
chemical_list: D000538:Aluminum Silicates; D008903:Minerals; D000077215:Clay