title: [Relationship of MPO and NQO1 gene polymorphisms with susceptibility to acute leukemia].
abstract: The aim of this study was to investigate the relationship of the gene polymorphisms of myeloperoxidase (MPO) and NAD (P) H: quinone oxidoreductase 1 (NQO1) with the susceptibility to acute leukemia (AL) in Chinese Gansu population. A 1:1 paired case-control study of 150 patients with acute leukemia and 150 cancer-free inpatients as a control was conducted to detect the polymorphisms of MPO and NQO1 by LDR techniques. The results showed that the MPO-463A genotype frequency in patient group was lower than that in control group, and there was significant difference of MPO (G-463A) genotype between patient group and control group (χ(2) = 11.828, P < 0.05, OR = 0.368, 95%CI = 0.205 - 0.610). The NQO1-609T genotype frequency in patient group was higher than that in control group, and there was significant difference of NQO1 (C-609T) genotype between patient group and control group (χ(2) = 17.931, P < 0.05, OR = 1.428, 95%CI = 1.237 - 3.339). The combined gene analysis showed that the AML risk in patients carrying the wild genotypes of MPO and NQO1 was dropped to 33.6%. It is concluded that the MPO and NQO1 gene polymorphisms are associated with susceptibility to AL. The AL risk may decrease in patients carrying MPO (G-463A) mutant gene (GA/AA), while the AL risk may increase in patients carrying NQO1 (C-609T) mutant gene (TC/TT). The combined effect of MPO and NQO1 wild genotypes may further decrease AL risk.
authors.affiliation: Institute of Hematology and Department of Hematology, The First Clinical Hospital, Lanzhou University, Lanzhou 730000, Gansu Province, China.
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Jia
authors.forename: Ya-Ming
authors.initials: YM
authors.lastname: Xi
authors.forename: Xiu-E
authors.initials: XE
authors.lastname: Shi
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Pei
authors.initials: P
authors.lastname: Li
authors.forename: Jian-Wang
authors.initials: JW
authors.lastname: Xu
authors.forename: Hai-Zhen
authors.initials: HZ
authors.lastname: Ma
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D009195:Peroxidase / Q000235:genetics*; D055815:Young Adult
chemical_list: D009195:Peroxidase; D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human