title: Humans put their eggs in more than one basket.
abstract: Primordial germ cell (PGC) development in the human fetus remains relatively uncharted. A new study suggests that epigenetic reprogramming and sex differentiation in human PGCs occur asynchronously over an extended time period. This finding raises questions and implications for in vitro PGC differentiation.
authors.affiliation: Department of Ob/Gyn, Center for Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Science, UCSF, 35 Medical Center Way, San Francisco, California 94143, USA. lairdd@obgyn.ucsf.edu
authors.forename: Diana J
authors.initials: DJ
authors.lastname: Laird
mesh_terms: D002454:Cell Differentiation; D005260:Female; D018392:Genomic Imprinting; D005854:Germ Cells / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D008297:Male; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*
chemical_list: D019009:Proto-Oncogene Proteins c-kit