title: Trimeric hemibastadin congener from the marine sponge Ianthella basta.
abstract: The first naturally occurring trimeric hemibastadin congener, sesquibastadin 1 (1), and the previously reported bastadins 3, 6, 7, 11, and 16 (2-6) were isolated from the marine sponge Ianthella basta, collected in Indonesia. The structure of 1 was elucidated on the basis of 1D and 2D NMR measurements and by HRMS. Among all the isolated compounds, the linear sesquibastadin 1 (1) and bastadin 3 (2) showed the strongest inhibition rates for at least 22 protein kinases (IC(50) = 0.1-6.5 μM), while the macrocyclic bastadins (3-6) demonstrated a strong cytotoxic potential against the murine lymphoma cell line L5178Y (IC(50) = 1.5-5.3 μM).
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Niemann
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.forename: Werner E G
authors.initials: WE
authors.lastname: Müller
authors.forename: Michael
authors.initials: M
authors.lastname: Kubbutat
authors.forename: Daowan
authors.initials: D
authors.lastname: Lai
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D055768:Halogenated Diphenyl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D055768:Halogenated Diphenyl Ethers; D047428:Protein Kinase Inhibitors; C515158:bastadin 6; C579375:sesquibastadin