title: Axonal anatomy of molecular layer heterotopia of the cerebellar vermis.
abstract: C57BL/6 mice and closely related strains exhibit heterotopia in the molecular layer of folia VIII and IX of the cerebellar vermis. Previously, we demonstrated that heterotopia are composed primarily of granule cells, Golgi cells, and GABAergic interneurons and are indicative of neuronal migration defect. In the present report we use immunocytochemistry and Thy1-YFP reporter mice to reveal the axonal constituents of cerebellar heterotopia which include mossy fibers, as well as serotonergic, cholinergic, and catecholaminergic axons. These data are relevant toward understanding of the mechanisms of axonal targeting during normal and abnormal cerebellar development.
authors.affiliation: Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Van Dine
authors.forename: Elsaid
authors.initials: E
authors.lastname: Salem
authors.forename: Dhruv B
authors.initials: DB
authors.lastname: Patel
authors.forename: Elizabeth
authors.initials: E
authors.lastname: George
authors.forename: Raddy L
authors.initials: RL
authors.lastname: Ramos
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D002531:Cerebellum / Q000166:cytology*; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D018613:Microscopy, Confocal