title: Sprague-Dawley rats bearing McA-RH7777 cells for study of hepatoma and transarterial chemoembolization.
abstract: OBJECTIVE
  To evaluate the feasibility of the McA-RH7777 tumor model in Sprague-Dawley (SD) rats, for study of hepatoma and transarterial chemoembolization.
  
  
  METHODS
  McA-RH7777 rat hepatoma cells (1×10(7)) were inoculated into the left hepatic lobe of SD rats (n=38). Chemoembolization with left common carotid artery access was performed using an emulsion of iodized oil and doxorubicin, and polyvinyl alcohol particles. Tumor induction rate and response to chemoembolization were assessed by magnetic resonance imaging and histology.
  
  
  RESULTS
  Tumor induction rate of McA-RH7777 in SD rat livers was 73.3% (11/15). Hematoxylin-and-eosin staining revealed hypercellular tumor with a trabecular pattern that mimics human hepatocellular carcinoma. Chemoembolization was successfully conducted in all rats. There was a significant difference in tumor growth rates between the chemoembolization-treated and control groups (p<0.0001).
  
  
  CONCLUSIONS
  A rat tumor model of McA-RH7777 cells in SD rats is feasible and has the potential to be a good model for hepatoma and chemoembolization studies.
authors.affiliation: Department of Radiology, Seoul National University Hospital, # 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Korea. angiointervention@gmail.com
authors.forename: Hye Rim
authors.initials: HR
authors.lastname: Cho
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Choi
authors.forename: Hyo-Cheol
authors.initials: HC
authors.lastname: Kim
authors.forename: Yong Sub
authors.initials: YS
authors.lastname: Song
authors.forename: Gyoung Min
authors.initials: GM
authors.lastname: Kim
authors.forename: Kyu Ri
authors.initials: KR
authors.lastname: Son
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Chung
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology; D002339:Carotid Arteries / Q000601:surgery; D016461:Chemoembolization, Therapeutic; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D008279:Magnetic Resonance Imaging; D011142:Polyvinyl Alcohol / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007459:Iodized Oil; D004317:Doxorubicin; D011142:Polyvinyl Alcohol