title: Prospects in the total synthesis of protein therapeutics.
abstract: Protein therapeutics are gaining headway in the treatment and prevention of a variety of maladies. Critical to the success and growing use of biologic-level pharmaceuticals is the development of methods for their precise synthesis. This review highlights the emerging techniques for the total synthesis of proteins, with a special focus on the possibility of accessing therapeutic targets through chemoselective peptide ligations.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Tulsa, Keplinger Hall M245, 800 South Tucker Drive, Tulsa, OK 74104-9700, USA. justinchalker@utulsa.edu
authors.forename: Justin M
authors.initials: JM
authors.lastname: Chalker
mesh_terms: D003545:Cysteine / Q000737:chemistry; D004921:Erythropoietin / Q000138:chemical synthesis; D006801:Humans; D016899:Interferon-beta / Q000138:chemical synthesis; D010281:Parathyroid Hormone / Q000138:chemical synthesis; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000138:chemical synthesis*; D012694:Serine / Q000737:chemistry
chemical_list: D010281:Parathyroid Hormone; D010455:Peptides; D011506:Proteins; D004921:Erythropoietin; D012694:Serine; D016899:Interferon-beta; D003545:Cysteine