title: Update on nutrients involved in maintaining healthy bone.
abstract: Osteoporosis is a leading cause of morbidity and mortality in the elderly and influences quality of life, as well as life expectancy. Currently, there is a growing interest among the medical scientists in search of specific nutrients and/or bioactive compounds of natural origin for the prevention of disease and maintenance of bone health. Although calcium and vitamin D have been the primary focus of nutritional prevention of osteoporosis, a recent research has clarified the importance of several additional nutrients and food constituents. Based on this review of the literature, supplementation with vitamins B, C, K, and silicon could be recommended for proper maintenance of bone health, although further clinical studies are needed. The results of studies on long-chain polyunsaturated fatty acids, potassium, magnesium, copper, selenium, and strontium are not conclusive, although studies in vitro and in animal models are interesting and promising.
authors.affiliation: Department of Applied Health Sciences, Section of Human Nutrition and Dietetics, Faculty of Medicine, University of Pavia, Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona di Pavia, Pavia, Italy. mariangela.rondanelli@unipv.it
authors.forename: Mariangela
authors.initials: M
authors.lastname: Rondanelli
authors.forename: Annalisa
authors.initials: A
authors.lastname: Opizzi
authors.forename: Simone
authors.initials: S
authors.lastname: Perna
authors.forename: Milena Anna
authors.initials: MA
authors.lastname: Faliva
mesh_terms: D000596:Amino Acids / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D005502:Food; D006801:Humans; D008903:Minerals / Q000627:therapeutic use; D010024:Osteoporosis / Q000517:prevention & control*; D011506:Proteins / Q000627:therapeutic use; D014803:Vitamin B Complex / Q000627:therapeutic use; D014812:Vitamin K / Q000627:therapeutic use
chemical_list: D000596:Amino Acids; D008903:Minerals; D011506:Proteins; D014803:Vitamin B Complex; D014812:Vitamin K; D001205:Ascorbic Acid