title: A case of thymic Langerhans cell histiocytosis with diabetes insipidus as the first presentation.
abstract: Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. LCH rarely involves the thymus. We report a case of thymic LCH with diabetes insipidus as the first presentation, without evidence of myasthenia gravis and without evidenced involvement of the skin, liver, spleen, bones, lungs and superficial lymph nodes. This present case may have important clinical implications. In screening for LCH lesions, attention should be attached to rarely involved sites in addition to commonly involved organs. Follow-up and imageological examination are very important to a final diagnosis.
authors.affiliation: Department of Endocrinology, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, 510120, China. gzscxy@126.com
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Chen
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Huang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Qiu
authors.forename: Hanzhang
authors.initials: H
authors.lastname: Chen
authors.forename: Yingyu
authors.initials: Y
authors.lastname: Fu
authors.forename: Xinchun
authors.initials: X
authors.lastname: Li
mesh_terms: D000293:Adolescent; D050034:Antidiuretic Agents / Q000008:administration & dosage; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage; D003919:Diabetes Insipidus / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010902:Pituitary Gland / Q000473:pathology / Q000503:physiopathology; D013934:Thymectomy / Q000379:methods; D013950:Thymus Gland / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin