title: A facile synthesis, antibacterial activity of pulvinone and its derivatives.
abstract: Pulvinone and several 3-fluoro-4-morpholino substituted pulvinone derivatives were synthesized in five steps from a common precursor, phenyl acetic acid. Most of synthetic morpholine substituted pulvinones showed inhibitory activity against Esherichia coli. For the first time, the inhibition of pulvinone and its derivatives against Gram-negative bacteria was reported.
authors.affiliation: New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, No. 100, KeXue DaDao, Zhengzhou 450001, China. xhwei01@126.com
authors.forename: Hai-Wei
authors.initials: HW
authors.lastname: Xu
authors.forename: Chao
authors.initials: C
authors.lastname: Xu
authors.forename: Zi-qi
authors.initials: ZQ
authors.lastname: Fan
authors.forename: Ling-Jie
authors.initials: LJ
authors.lastname: Zhao
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Liu
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000081:Acetamides / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001597:Benzylidene Compounds / Q000737:chemistry* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D023303:Oxazolidinones / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D001597:Benzylidene Compounds; D023303:Oxazolidinones; D000069349:Linezolid; D015107:4-Butyrolactone; C581844:pulvinone