title: The role of complement in experimental autoimmune myasthenia gravis.
abstract: Complement plays an important role in the pathophysiology of experimental autoimmune myasthenia gravis (EAMG). The deposition of IgG at the neuromuscular junction, followed by the activation and observance of C3 at the site, and finally the insertion of the membrane attack complex results in the destruction of the plasma membrane at the neuromuscular junction. Animal models of complement-deficient components show the importance of the mediated lysis in EAMG. These events have regulators that allow for the limitation in the cascade and the ability of the cell to inhibit complement at many places along the pathway. The complement regulatory proteins have many roles in reducing the activation of the complement cascade and the inflammatory pathways. Mice deficient in complement regulatory proteins, decay accelerating factor, and CD59 demonstrate a significant increase in the destruction at the neuromuscular junction. Inhibition of complement-mediated lysis is an attractive therapeutic in MG.
authors.affiliation: Department of Pharmacology and Physiology, The George Washington University, Washington, DC, USA. lkusner@gwu.edu
authors.forename: Linda L
authors.initials: LL
authors.lastname: Kusner
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Kaminski
mesh_terms: D000818:Animals; D018957:CD59 Antigens / Q000276:immunology / Q000378:metabolism; D003186:Complement C9 / Q000276:immunology / Q000378:metabolism; D003165:Complement System Proteins / Q000172:deficiency / Q000276:immunology* / Q000378:metabolism*; D051379:Mice; D020720:Myasthenia Gravis, Autoimmune, Experimental / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000276:immunology / Q000378:metabolism
chemical_list: D018957:CD59 Antigens; D003186:Complement C9; D003165:Complement System Proteins