title: Global standardization measurement of cerebral spinal fluid for Alzheimer's disease: an update from the Alzheimer's Association Global Biomarkers Consortium.
abstract: Recognizing that international collaboration is critical for the acceleration of biomarker standardization efforts and the efficient development of improved diagnosis and therapy, the Alzheimer's Association created the Global Biomarkers Standardization Consortium (GBSC) in 2010. The consortium brings together representatives of academic centers, industry, and the regulatory community with the common goal of developing internationally accepted common reference standards and reference methods for the assessment of cerebrospinal fluid (CSF) amyloid β42 (Aβ42) and tau biomarkers. Such standards are essential to ensure that analytical measurements are reproducible and consistent across multiple laboratories and across multiple kit manufacturers. Analytical harmonization for CSF Aβ42 and tau will help reduce confusion in the AD community regarding the absolute values associated with the clinical interpretation of CSF biomarker results and enable worldwide comparison of CSF biomarker results across AD clinical studies.
authors.affiliation: Division Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA. maria.carrillo@alz.org
authors.forename: Maria C
authors.initials: MC
authors.lastname: Carrillo
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.forename: Holly
authors.initials: H
authors.lastname: Soares
authors.forename: Piotr
authors.initials: P
authors.lastname: Lewczuk
authors.forename: Niklas
authors.initials: N
authors.lastname: Mattsson
authors.forename: Pankaj
authors.initials: P
authors.lastname: Oberoi
authors.forename: Robert
authors.initials: R
authors.lastname: Umek
authors.forename: Manu
authors.initials: M
authors.lastname: Vandijck
authors.forename: Salvatore
authors.initials: S
authors.lastname: Salamone
authors.forename: Tobias
authors.initials: T
authors.lastname: Bittner
authors.forename: Leslie M
authors.initials: LM
authors.lastname: Shaw
authors.forename: Diane
authors.initials: D
authors.lastname: Stephenson
authors.forename: Lisa
authors.initials: L
authors.lastname: Bain
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D042241:Early Diagnosis; D006801:Humans; D012015:Reference Standards
chemical_list: D015415:Biomarkers