title: Anti-stress and anti-allergic effect of Actiniopteris radiata in some aspects of asthma.
abstract: Successive extracts of whole plant of Actiniopteris radiata screened for its therapeutic potential as an antiallergic and antistress agent in asthma using specific in vivo animal models. Only ethanol extract (AREE) at a higher dose of 100 mg/kg i.p significantly (p < 0.05) decreased milk induced eosinophilia by 16.20 ± 2.235 when compared with control group while even lower doses of 50 mg/kg, i.p exhibited significant inhibition (P  < 0.05) of leukocytosis induced by milk in mice. Other extracts like petroleum ether, ethyl acetate and methanol unable to exhibit that significant potential. Results obtained thus validate the traditional claim of the Actiniopteris radiata utilization in different aspect of asthma due to presence of various polar secondary metabolites in ethanol extract.
authors.affiliation: Smt. SS Patil College of Pharmacy, Chopda, MS, India. gautamvadnere31@rediffmail.com
authors.forename: Gautam Prakash
authors.initials: GP
authors.lastname: Vadnere
authors.forename: Aslam Ramjan
authors.initials: AR
authors.lastname: Pathan
authors.forename: Abhay Kumar
authors.initials: AK
authors.lastname: Singhai
authors.forename: Bharti Uday
authors.initials: BU
authors.lastname: Kulkarni
authors.forename: Jogendra Chandrakant
authors.initials: JC
authors.lastname: Hundiwale
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004802:Eosinophilia / Q000139:chemically induced / Q000517:prevention & control*; D000431:Ethanol / Q000737:chemistry; D005260:Female; D029624:Ferns / Q000737:chemistry; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D007964:Leukocytosis / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008892:Milk; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry
chemical_list: D018926:Anti-Allergic Agents; D018927:Anti-Asthmatic Agents; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol