title: Occurrence of arsenic impurities in organoarsenics and animal feeds.
abstract: Organoarsenics are widely used as excellent feed additives in animal production in the world. Roxarsone (ROX) and arsanilic acid (ASA) are two organoarsenics permitted to be used in China. We collected 146 animal feed samples to investigate the appearance of ROX, ASA, and potential metabolites, including 3-amino-4-hydroxyphenylarsonic acid (3-A-HPA), 4-hydroxyphenylarsonic acid (4-HPA), As(V), As(III), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) in feeds. The stability of ROX in both ROX additives and animal feeds was also examined. The results show that 25.4% of the 146 animal feeds contained organoarsenics, with average contents of ROX and ASA as 7.0 and 21.2 mg of As/kg, respectively. Unexpectedly, As(III) and MMA frequently occurred as As impurities in feeds bearing organoarsenics, with higher contents than organoarsenics in some samples. 3-A-HPA, 4-HPA, and DMA were not detected in all samples. ROX and As impurities in both ROX additives and feeds stayed unchanged in the shelf life. It suggests that As impurities in animal feeds bearing organoarsenics should generate from the use of organoarsenics containing As impurities. This constitutes the first report of As impurities in organoarsenics.
authors.affiliation: Key Laboratory of Plant Nutrition and Fertilizer in South Region, Ministry of Agriculture, Institute of Agricultural Resources and Environment, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, People's Republic of China. lyaolx@yahoo.com.cn
authors.forename: Lixian
authors.initials: L
authors.lastname: Yao
authors.forename: Lianxi
authors.initials: L
authors.lastname: Huang
authors.forename: Zhaohuan
authors.initials: Z
authors.lastname: He
authors.forename: Changmin
authors.initials: C
authors.lastname: Zhou
authors.forename: Guoliang
authors.initials: G
authors.lastname: Li
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D001147:Arsanilic Acid / Q000737:chemistry*; D001152:Arsenicals / Q000032:analysis*; D002645:Chickens; D002681:China; D003049:Coccidiostats / Q000737:chemistry; D004355:Drug Stability; D005503:Food Additives / Q000737:chemistry*; D005506:Food Contamination; D012406:Roxarsone / Q000737:chemistry*; D034421:Sus scrofa
chemical_list: D000900:Anti-Bacterial Agents; D001152:Arsenicals; D003049:Coccidiostats; D005503:Food Additives; D012406:Roxarsone; D001147:Arsanilic Acid