title: [Radiofrequency ablation therapy combined with hepatectomy for liver metastasis of colorectal cancer].
abstract: Radiofrequency ablation (RFA) therapy combined with hepatectomy was performed in 5 patients with synchronous liver metastases of colorectal cancer. RFA of liver metastases was performed using a Cool-tip electrode (Radionics; Burlington, MA, USA). The ablation time used in each session varied according to the tumor size and intraoperative impedance. In 2 patients, hepatectomy and resection of the colorectal primary lesion were performed synchronously. In patients with multiple liver metastases, relative curative resection was performed using the complementary RFA. In the other 3 patients, synchronous hepatectomy was considered difficult and systematic chemotherapy was performed after resection of the colorectal primary lesion. After systematic chemotherapy, the range of hepatectomy was restricted for liver injury, but relative curative resection was performed using RFA therapy. Computed tomography performed after hepatectomy showed that the region that underwent RFA appeared necrotic with a safety margin. The average observation period was 25 months (maximal survival period, 50 months) and 3 of the patients are alive.
authors.affiliation: Dept. of Gastroenterogical Surgery, National Hospital Organization, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Otsuka
authors.forename: Masaru
authors.initials: M
authors.lastname: Inagaki
authors.forename: Yuuji
authors.initials: Y
authors.lastname: Kimura
authors.forename: Kenta
authors.initials: K
authors.lastname: Isoda
authors.forename: Kouji
authors.initials: K
authors.lastname: Kitada
authors.forename: Manabu
authors.initials: M
authors.lastname: Nishie
authors.forename: Ryousuke
authors.initials: R
authors.lastname: Hamano
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Tokunaga
authors.forename: Hideaki
authors.initials: H
authors.lastname: Miyasou
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Tsunemitsu
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Iwakawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Iwagaki
mesh_terms: D000328:Adult; D000368:Aged; D017115:Catheter Ablation; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged