title: Wang linker free of side reactions.
abstract: A new resin for the solid-phase synthesis of peptide acids was developed. It was based on a linker with two unique features: methoxy groups as the only activating groups of the phenyl ring and a copper(I)-catalyzed Click chemistry reaction to anchor it to the solid support. The efficiency of this new resin in solid phase peptide synthesis was compared with that of Wang resin.
authors.affiliation: Institute for Research in Biomedicine , 08028-Barcelona, Spain.
authors.forename: Vida
authors.initials: V
authors.lastname: Castro
authors.forename: Hortensia
authors.initials: H
authors.lastname: Rodriguez
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
mesh_terms: D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011137:Polystyrenes / Q000138:chemical synthesis*; D060327:Solid-Phase Synthesis Techniques
chemical_list: D010455:Peptides; D011137:Polystyrenes; C514402:Wang resin; D003300:Copper