title: Solubilization of poorly water-soluble drugs using solid dispersions.
abstract: Many new drugs have been discovered in pharmaceutical industry and exposed their surprised potential therapeutic effects. Unfortunately, these drugs possess low absorption and bioavailability since their solubility limitation in water. Solid dispersion (SD) is the current technique gaining so many attractions from scientists due to its effect on improving solubility and dissolution rate of poorly water-soluble drugs. A number of patents including the most recent inventions have been undertaken in this review to address various respects of this strategy in solubilization of poorly watersoluble drugs including type of carriers, preparation methods and view of technologies used to detect SD properties and mechanisms with the aim to accomplish a SD not only effective on enhanced bioavailability but also overcome difficulties associated with stability and production. Future prospects are as well discussed with an only hope that many developments and researches in this field will be successfully reached and contributed to commercial use for treatment as much as possible.
authors.affiliation: International University- Vietnam National University, Ho Chi Minh City, Vietnam. ttdthao@hcmiu.edu.vn
authors.forename: Thao T-D
authors.initials: TT
authors.lastname: Tran
authors.forename: Phuong H-L
authors.initials: PH
authors.lastname: Tran
authors.forename: Tran N
authors.initials: TN
authors.lastname: Khanh
authors.forename: Toi V
authors.initials: TV
authors.lastname: Van
authors.forename: Beom-Jin
authors.initials: BJ
authors.lastname: Lee
mesh_terms: D001682:Biological Availability; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding; D016503:Drug Delivery Systems; D055808:Drug Discovery; D004355:Drug Stability; D006801:Humans; D010330:Patents as Topic; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations