title: Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation.
abstract: SSAO/VAP-1 participates in the accumulation of leukocytes at the site of inflammation. A new SSAO inhibitor, SzV-1287 was demonstrated to inhibit both acute and chronic inflammation in rats more effectively than the known enzyme inhibitor, LJP-1207. Surprisingly, the SSAO activity was not increased, but decreased both in acute and chronic inflammation. Though experiments are in progress to clarify these findings, the enzyme might play a role in the very early phase of inflammation and be inactivated during leukocyte extravasation.
authors.affiliation: Department of Pharmacodynamics, Semmelweis University, Nagyvárad tér 4, 1089, Budapest, Hungary. tabi.tamas@pharma.semmelweis-univ.hu
authors.forename: Tamás
authors.initials: T
authors.lastname: Tábi
authors.forename: Eva
authors.initials: E
authors.lastname: Szökő
authors.forename: Anita
authors.initials: A
authors.lastname: Mérey
authors.forename: Veronika
authors.initials: V
authors.lastname: Tóth
authors.forename: Péter
authors.initials: P
authors.lastname: Mátyus
authors.forename: Klára
authors.initials: K
authors.lastname: Gyires
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D002351:Carrageenan / Q000633:toxicity; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D007839:Functional Laterality; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006834:Hydrazines / Q000627:therapeutic use; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000208:ethnology*; D008297:Male; D010080:Oxazoles / Q000627:therapeutic use*; D010091:Oximes / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: C000613315:3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime; D004791:Enzyme Inhibitors; D006834:Hydrazines; C506836:N'-(2-phenylallyl)hydrazine; D010080:Oxazoles; D010091:Oximes; D002351:Carrageenan; D006631:Amine Oxidase (Copper-Containing)