title: [A case of advanced hepatocellular carcinoma with tumor thrombosis in the main trunk of the portal vein successfully treated by multidisciplinary therapies].
abstract: We report a case of advanced hepatocellular carcinoma(HCC) with tumor thrombosis in the main trunk of the portal vein successfully treated by multidisciplinary therapies. This case is that of a 61-year-old man with loss of appetite and weight loss. The abdominal computed tomography revealed an early enhanced and late wash-out lesion in the right hepatic lobe and tumor thrombosis in the major trunk of the portal vein. We diagnosed advanced HCC related to chronic hepatitis C [T4 (Vp4) N0M0, Stage IVA] and performed extended right lobectomy and extraction of the tumor thrombosis. The patient then underwent hepatic arterial infusion of 5-fluorouracil (5-FU) combined with systemic administration of interferon (IFN)-α therapy as an adjuvant therapy. Two years have passed since these therapies were performed with no recurrence of the disease. We expected that the patient would achieve long-term survival. Therefore, we administered IFN/ribavirin (RBV) therapy for chronic hepatitis C for 48 weeks. The patient is still alive, 44 months after the initial treatment. This case suggests that some patients with advanced HCC and a tumor thrombosis can achieve long-term survival by multidisciplinary therapies, including IFN-α/5-FU combination therapy.
authors.affiliation: Dept. of Surgery, Osaka University Graduate School of Medicine, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Eguchi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Marubashi
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wada
authors.forename: Shogo
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tanemura
authors.forename: Koji
authors.initials: K
authors.lastname: Umeshita
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Doki
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nagano
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000628:therapy* / Q000821:virology; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000628:therapy* / Q000821:virology; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D013927:Thrombosis / Q000209:etiology* / Q000601:surgery