title: Reactive control of epileptiform discharges in realistic computational neuronal models with bistability.
abstract: We aim to derive fully autonomous seizure suppression paradigms based on reactive control of neuronal dynamics. A previously derived computational model of seizure generation describing collective degrees of freedom and featuring bistable dynamics is used. A novel technique for real-time control of epileptogenicity is introduced. The reactive control reduces practically all seizures in the model. The study indicates which parameters provide the maximal seizure reduction with minimal intervention. An adaptive scheme is proposed that optimizes the stimulation parameters in nonstationary situations.
authors.affiliation: Stichting Epilepsie Instellingen Nederland, Netherlands. mkoppert@sein.nl
authors.forename: Marc
authors.initials: M
authors.lastname: Koppert
authors.forename: Stiliyan
authors.initials: S
authors.lastname: Kalitzin
authors.forename: Demetrios
authors.initials: D
authors.lastname: Velis
authors.forename: Fernando Lopes
authors.initials: FL
authors.lastname: DA Silva
authors.forename: Max A
authors.initials: MA
authors.lastname: Viergever
mesh_terms: D003198:Computer Simulation; D004867:Equipment Design / Q000379:methods* / Q000592:standards*; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology* / Q000628:therapy