title: reSETting chromatin during transcription elongation.
abstract: Maintenance of ordered chromatin structure over the body of genes is vital for the regulation of transcription. Increased access to the underlying DNA sequence results in the recruitment of RNA polymerase II to inappropriate, promoter-like sites within genes, resulting in unfettered transcription. Two new papers show how the Set2-mediated methylation of histone H3 on Lys36 (H3K36me) maintains chromatin structure by limiting histone dynamics over gene bodies, either by recruiting chromatin remodelers that preserve ordered nucleosomal distribution or by lowering the binding affinity of histone chaperones for histones, preventing their removal.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, MO, USA.
authors.forename: Michaela
authors.initials: M
authors.lastname: Smolle
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Workman
authors.forename: Swaminathan
authors.initials: S
authors.lastname: Venkatesh
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics*; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D056284:Histone Deacetylase 1 / Q000378:metabolism; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D061805:Transcription Elongation, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D011495:Histone-Lysine N-Methyltransferase; D056284:Histone Deacetylase 1