title: Evaluation of anti-inflammatory activity of Typha angustifolia pollen grains extracts in experimental animals.
abstract: OBJECTIVE
  This study was designed to evaluate the anti-inflammatory activity of aqueous and 70% methanolic extracts of pollen grains of Typha angustifolia.
  
  
  METHODS
  Female Sprague Dawley rats were used for the study. The acute anti-inflammatory activity of pollen grains of T. angustifolia was studied using the carrageenan as phlogistic agent, whereas its chronic anti-inflammatory effect was investigated by the percentage inhibition of cotton pellet-induced granuloma.
  
  
  RESULTS
  Both aqueous and 70% methanolic extracts of pollen grains of T. angustifolia showed significant dose-dependent inhibition of carrageenan-induced paw edema as compared to the control (P<0.001). It was observed that both the extracts at dose of 125 mg/kg inhibited the granuloma formation by 44.30% which is higher than at dose of 500, 250 mg/kg, thus causing a significant (P<0.001) non-dose-related inhibition of granuloma formation.
  
  
  CONCLUSIONS
  The results of this study indicate that extracts of pollen grains of T. angustifolia are effective in the treatment of both acute and chronic inflammatory conditions and thus support its traditional utilization.
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai, India.
authors.forename: Saroj S
authors.initials: SS
authors.lastname: Varpe
authors.forename: Archana R
authors.initials: AR
authors.lastname: Juvekar
authors.forename: Mukta P
authors.initials: MP
authors.lastname: Bidikar
authors.forename: Parikshit R
authors.initials: PR
authors.lastname: Juvekar
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002351:Carrageenan; D032561:Cotton Fiber; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D006099:Granuloma / Q000188:drug therapy* / Q000209:etiology; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011058:Pollen; D051381:Rats; D017207:Rats, Sprague-Dawley; D023382:Toxicity Tests, Acute; D032401:Typhaceae
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan