title: Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology.
abstract: Single-molecule (SM) spectroscopy has been an exciting area of research offering significant promise and hope in the field of sensor development to detect targets at ultra-low levels down to SM resolution. To the experts and developers in the field of surface-enhanced Raman spectroscopy (SERS), this has often been a challenge and a significant opportunity for exploration. Needless to say, the opportunities and excitement of this multidisciplinary area impacts span the fields of physics, chemistry and engineering, along with a significant thrust in applications constituting areas in medicine, biology, environment and agriculture among others. In this review, we will attempt to provide a quick snapshot of the basics of SM-SERS, nanostructures and devices that can enable SM Raman measurement. We will conclude with a discussion on SERS implications in biomedical sciences.
authors.affiliation: Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Wang
authors.forename: Joseph
authors.initials: J
authors.lastname: Irudayaraj
mesh_terms: D008841:Actin Cytoskeleton / Q000737:chemistry; D000255:Adenosine Triphosphate / Q000737:chemistry; D001665:Binding Sites; D004926:Escherichia coli / Q000737:chemistry / Q000201:enzymology*; D029968:Escherichia coli Proteins / Q000737:chemistry; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry; D006868:Hydrolysis; D059346:Magnets / Q000737:chemistry; D018715:Microscopy, Video; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D011485:Protein Binding; D006180:Proton-Translocating ATPases / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D029968:Escherichia coli Proteins; D005456:Fluorescent Dyes; D000255:Adenosine Triphosphate; D006180:Proton-Translocating ATPases