title: Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.
abstract: To identify new genetic factors for colorectal cancer (CRC), we conducted a                 genome-wide association study in east Asians. By analyzing genome-wide data in 2,098                 cases and 5,749 controls, we selected 64 promising SNPs for replication in an                 independent set of samples, including up to 5,358 cases and 5,922 controls. We                 identified four SNPs with association P values of 8.58 ×                     10(-7) to 3.77 × 10(-10)                 in the combined analysis of all east Asian samples. Three of the four were                 replicated in a study conducted in 26,060 individuals of European descent, with                 combined P values of 1.22 × 10(-10) for                 rs647161 (5q31.1), 6.64 × 10(-9) for rs2423279                 (20p12.3) and 3.06 × 10(-8) for rs10774214                 (12p13.32 near the CCND2 gene), derived from meta-analysis of data from both                 east Asian and European-ancestry populations. This study identified three new CRC                 susceptibility loci and provides additional insight into the genetics and biology of                 CRC.
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jia
authors.forename: Ben
authors.initials: B
authors.lastname: Zhang
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Aesun
authors.initials: A
authors.lastname: Shin
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Jee
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Zefang
authors.initials: Z
authors.lastname: Ren
authors.forename: Qiuyin
authors.initials: Q
authors.lastname: Cai
authors.forename: Jirong
authors.initials: J
authors.lastname: Long
authors.forename: Jiajun
authors.initials: J
authors.lastname: Shi
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wen
authors.forename: Gong
authors.initials: G
authors.lastname: Yang
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Delahanty
authors.forename: Bu-Tian
authors.initials: BT
authors.lastname: Ji
authors.forename: Zhi-Zhong
authors.initials: ZZ
authors.lastname: Pan
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Matsuda
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Jae Hwan
authors.initials: JH
authors.lastname: Oh
authors.forename: Yoon-Ok
authors.initials: YO
authors.lastname: Ahn
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Park
authors.forename: Hong-Lan
authors.initials: HL
authors.lastname: Li
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Park
authors.forename: Jaeseong
authors.initials: J
authors.lastname: Jo
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Jeong
authors.forename: Satoyo
authors.initials: S
authors.lastname: Hosono
authors.forename: Graham
authors.initials: G
authors.lastname: Casey
authors.forename: Ulrike
authors.initials: U
authors.lastname: Peters
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Zeng
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
mesh_terms: D044466:Asian People / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D056742:Cyclin D2 / Q000235:genetics; D005202:Asia, Eastern; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005828:Genetics, Population; D015894:Genome, Human / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D025341:Principal Component Analysis; D044465:White People / Q000235:genetics
chemical_list: C080336:CCND2 protein, human; D056742:Cyclin D2