title: [Glandular papilloma of the right main bronchus. Detection of an exon 2 mutation of the KRAS gene (c.35G>A)].
abstract: Benign epithelial tumors of the tracheobronchial system and the lungs are exceedingly rare. These entities encompass squamous and glandular papillomas (as well as their mixed forms) and adenomas (alveolar adenoma, papillary adenoma, salivary gland-like pleomorphic and mucinous adenomas and mucinous cystadenomas). These tumors are considered to be biologically benign neoplasms; however, they can pose considerable diagnostic difficulties, especially during frozen section evaluation, as they can mimic malignant tumors and in particular they can resemble well differentiated papillary adenocarcinomas. As a result of the extreme rarity of these tumors only a few descriptive diagnostic series exist and a systematic investigation including molecular data does not exist. This article presents the case of a 64-year-old patient with a glandular papilloma of the right main bronchus including the immunohistochemical and molecular work-up as well as a review of the current literature.
authors.affiliation: Institut für Pathologie und Neuropathologie, Universitätsklinik Essen, Universität Duisburg-Essen, Hufelandstrasse 55, Essen, Germany. jeremias.wohlschlaeger@uk-essen.de
authors.forename: J
authors.initials: J
authors.lastname: Wohlschläger
authors.forename: S
authors.initials: S
authors.lastname: Welter
authors.forename: G
authors.initials: G
authors.lastname: Stamatis
authors.forename: D
authors.initials: D
authors.lastname: Theegarten
authors.forename: T
authors.initials: T
authors.lastname: Hager
authors.forename: F
authors.initials: F
authors.lastname: Mairinger
authors.forename: K
authors.initials: K
authors.lastname: Worm
authors.forename: K W
authors.initials: KW
authors.lastname: Schmid
authors.forename: K M
authors.initials: KM
authors.lastname: Müller
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000235:genetics / Q000473:pathology; D019943:Amino Acid Substitution / Q000235:genetics; D001216:Asparagine / Q000235:genetics; D001980:Bronchi / Q000473:pathology / Q000601:surgery; D001984:Bronchial Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D001999:Bronchoscopy; D003937:Diagnosis, Differential; D066246:ErbB Receptors / Q000235:genetics; D005091:Exons / Q000235:genetics*; D005260:Female; D005629:Frozen Sections; D005998:Glycine / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D010212:Papilloma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D011013:Pneumonectomy; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D017422:Sequence Analysis, DNA; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D018631:ras Proteins / Q000235:genetics*
chemical_list: C117307:KRAS protein, human; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; D001216:Asparagine; C512478:EGFR protein, human; D066246:ErbB Receptors; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins; D005998:Glycine