title: Coexistence of osteopoikilosis with seronegative spondyloarthritis and Raynaud's phenomenon: first case report with evaluation of the nailfold capillary bed and literature review.
abstract: Osteopoikilosis (OPK) is a rare autosomal dominant bone disorder characterized by numerous hyperostotic areas that tend to localize in periarticular osseous regions. It is usually asymptomatic and is often diagnosed incidentally during X-rays. OPK may be an isolated finding or associated with other pathologies, e.g. skin manifestations, rheumatic and/or skeletal disorders. We report a literature review and, for the first time, the coexistence of OPK with seronegative spondyloarthritis and Raynaud's phenomenon in a 48-year old female. To the best of our knowledge, this is the first case of OPK studied by videocapillaroscopy, demonstrating the absence of specific microvascular abnormalities of nailfold capillaries.
authors.affiliation: Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Ruaro
authors.forename: A
authors.initials: A
authors.lastname: Sulli
authors.forename: E
authors.initials: E
authors.lastname: Alessandri
authors.forename: F
authors.initials: F
authors.lastname: Ravera
authors.forename: M
authors.initials: M
authors.lastname: Cutolo
mesh_terms: D019644:Arthroplasty, Replacement, Hip; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D002196:Capillaries / Q000473:pathology; D005260:Female; D006801:Humans; D020678:Microscopic Angioscopy / Q000379:methods; D018715:Microscopy, Video; D008875:Middle Aged; D009262:Nails / Q000098:blood supply*; D015207:Osteoarthritis, Hip / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D010023:Osteopoikilosis / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D010384:Pelvic Bones / Q000000981:diagnostic imaging; D011859:Radiography; D011928:Raynaud Disease / Q000150:complications* / Q000473:pathology; D058566:Sacroiliitis / Q000150:complications / Q000000981:diagnostic imaging; D025241:Spondylarthritis / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging
chemical_list: D002097:C-Reactive Protein