title: Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009-2011.
abstract: During the 2009-2011 influenza seasons, 10.26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.
authors.affiliation: Department of Microbiology, Hallym University, Chuncheon 200-702, Republic of Korea.
authors.forename: Sehee
authors.initials: S
authors.lastname: Park
authors.forename: Jin Il
authors.initials: JI
authors.lastname: Kim
authors.forename: Ilseob
authors.initials: I
authors.lastname: Lee
authors.forename: Sangmoo
authors.initials: S
authors.lastname: Lee
authors.forename: Min-Woong
authors.initials: MW
authors.lastname: Hwang
authors.forename: Joon-Yong
authors.initials: JY
authors.lastname: Bae
authors.forename: Jun
authors.initials: J
authors.lastname: Heo
authors.forename: Eun-Joo
authors.initials: EJ
authors.lastname: Lim
authors.forename: Won-Seok
authors.initials: WS
authors.lastname: Seok
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Cheong
authors.forename: Joon Young
authors.initials: JY
authors.lastname: Song
authors.forename: Woo Joo
authors.initials: WJ
authors.lastname: Kim
authors.forename: Man-Seong
authors.initials: MS
authors.lastname: Park
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000235:genetics; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000235:genetics; D007251:Influenza, Human / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009439:Neuraminidase / Q000235:genetics; D053139:Oseltamivir / Q000494:pharmacology* / Q000627:therapeutic use; D056910:Republic of Korea; D010948:Viral Plaque Assay
chemical_list: D000998:Antiviral Agents; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D053139:Oseltamivir; D009439:Neuraminidase