title: One-pot efficient synthesis of N(α)-urethane-protected β- and γ-amino acids.
abstract: 1-[(4-Methylphenyl)oxy]pyrrolidine-2,5-dione and 1-[(4-methylphenyl)oxy]piperidine-2,6-dione react in a Lossen-type reaction with primary alcohols in the presence of triethylamine to furnish corresponding N(α)-urethane-protected β-alanine and γ-aminopropionic acid (GABA), respectively, with excellent yields and purities, in an essentially "one-pot" procedure.
authors.affiliation: Faculty of Chemistry, University of Wrocław, ul. F. Joliot-Curie 14, Wroclaw, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Cal
authors.forename: Mariusz
authors.initials: M
authors.lastname: Jaremko
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Jaremko
authors.forename: Piotr
authors.initials: P
authors.lastname: Stefanowicz
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D015394:Molecular Structure; D014520:Urethane / Q000737:chemistry*; D015091:beta-Alanine / Q000138:chemical synthesis* / Q000737:chemistry; D005680:gamma-Aminobutyric Acid / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D015091:beta-Alanine; D014520:Urethane; D005680:gamma-Aminobutyric Acid