title: Marijuana craving trajectories in an adolescent marijuana cessation pharmacotherapy trial.
abstract: Marijuana is the most widely used illicit substance among youths and recent epidemiological data indicate that rates of marijuana use are on the rise. The purpose of this study was to examine marijuana craving trajectories among adolescents in an eight-week, placebo-controlled pharmacotherapy trial targeting marijuana cessation. All participants received contingency management and cessation counseling, and were randomized to either N-acetylcysteine (1200mg NAC twice daily; n=45) or placebo (n=44). Craving for marijuana was measured using the short-form of the Marijuana Craving Questionnaire (MCQ). Results demonstrated a significant decrease in MCQ scores over time for the total sample, but no significant differential change in scores between the NAC and placebo groups. This lack of significant difference is in the setting of NAC participants submitting significantly more negative urine cannabinoid tests as compared to placebo participants. This suggests that cessation effects associated with NAC may be mediated by effects other than marijuana craving.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, United States. rotena@musc.edu
authors.forename: Amanda T
authors.initials: AT
authors.lastname: Roten
authors.forename: Nathaniel L
authors.initials: NL
authors.lastname: Baker
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Gray
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage*; D000293:Adolescent; D003131:Combined Modality Therapy / Q000379:methods; D003376:Counseling; D004334:Drug Administration Schedule; D018690:Excitatory Amino Acid Agonists / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000523:psychology / Q000534:rehabilitation*; D057566:Self Report; D013375:Substance Withdrawal Syndrome / Q000534:rehabilitation; D055815:Young Adult
chemical_list: D018690:Excitatory Amino Acid Agonists; D000111:Acetylcysteine