title: Solvent-free, metal-free, aza-Prins cyclization: unprecedented access to δ-sultams.
abstract: Aza-Prins and the pauper: Aza-Prins cyclization between γ,δ-unsaturated tosylamines and aldehydes was successfully performed under solvent-free and metal-free conditions. When applied to β,γ-unsaturated sulfonamides, the corresponding δ-sultams were isolated in good yields (see scheme). This approach constitutes a new route to cyclic sulfonamides.
authors.affiliation: Université Lyon1, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), UMR CNRS 5246, 43, Bd du 11 novembre 1918, 69622 Villeurbanne cedex, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Clarisse
authors.forename: Béatrice
authors.initials: B
authors.lastname: Pelotier
authors.forename: Fabienne
authors.initials: F
authors.lastname: Fache
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D001372:Aza Compounds; D013449:Sulfonamides