title: [Salvage hormonal therapy against recurrence after curative external beam radiotherapy for locally advanced prostate cancer at Kyoto University Hospital].
abstract: Fifty-three patients with biochemical relapse (BCR) after receiving external beam radiotherapy (EBRT) against locally advanced prostate cancer (stage III : International Union Against Cancer [UICC] 6th edition) between September 1997 and January 2006 at our institution, who were treated with salvage hormonal therapy (HTx), were followed for a mean period of 75.5 months. There was progression to castrationresistant prostate cancer (CRPC) during the follow-up period in 17 patients (32.0%). The median time to CRPC after initial HTx was 17 months. Univariate analysis revealed that time to BCR after EBRT was significantly associated with progression to CRPC (p＝0.022), while PSA-doubling time just before salvage HTx was marginally associated with irradiation dose (p＝0. 088, p＝0.128 respectively). Multivariate analysis showed that time to BCR after EBRT was the only significant predictor of progression to CRPC (p＝ 0.035, Hazard ratio ; 0.252, 95% confidence interval ; 0.070-0.905) conclusion, time to BCR after EBRT might be a good predictor for the efficiency of salvage HTx after EBRT against locally advanced prostate cancer.
authors.affiliation: The Department of Urology, Kyoto University Graduate School of Medicine.
authors.forename: Keiji
authors.initials: K
authors.lastname: Kato
authors.forename: Takahiro
authors.initials: T
authors.lastname: Inoue
authors.forename: Takashi
authors.initials: T
authors.lastname: Mizowaki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kamoto
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kamba
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Norihisa
authors.forename: Tomomi
authors.initials: T
authors.lastname: Yamada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hiraoka
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use; D001918:Brachytherapy; D002369:Castration; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D011471:Prostatic Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*
chemical_list: D000726:Androgen Antagonists; D007987:Gonadotropin-Releasing Hormone