title: Assessment of the efficacy of a new formulation for plantar wart mummification: new experimental design and human papillomavirus identification.
abstract: Cutaneous warts are caused by infection of the epidermis with human papillomavirus (HPV). Cryotherapy using liquid nitrogen is one of the most common local treatments. In this study, we used a novel ex vivo approach to compare the efficacy of a new product with conventional liquid-nitrogen cryotherapy by studying epidermal histology and assessing the presence of HPV types 1 and 2 DNA in plantar warts. The studied formulation, which acts by tissues mummification, is a combination of nitric acid, organic acids and metallic salts. We found that, similar to liquid nitrogen, the studied product induced alterations in the wart structure. In addition, unlike liquid nitrogen, this product also reduced the amount of HPV DNA. The results suggest that there is a poor correlation between the histological response and the antiviral efficacy of standard wart treatment.
authors.affiliation: Engineering and Cutaneous Biology Laboratory, INSERM UMR, SFR FED, University of Franche-Comte, Besançon, France. celine.viennet@univ-fcomte.fr
authors.forename: C
authors.initials: C
authors.lastname: Viennet
authors.forename: T
authors.initials: T
authors.lastname: Gheit
authors.forename: P
authors.initials: P
authors.lastname: Muret
authors.forename: F
authors.initials: F
authors.lastname: Aubin
authors.forename: J
authors.initials: J
authors.lastname: Cabou
authors.forename: A
authors.initials: A
authors.lastname: Marchal
authors.forename: M
authors.initials: M
authors.lastname: Tommasino
authors.forename: P
authors.initials: P
authors.lastname: Humbert
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D017679:Cryotherapy / Q000379:methods; D004279:DNA, Viral / Q000032:analysis; D004338:Drug Combinations; D006801:Humans; D017942:Nitric Acid / Q000627:therapeutic use*; D009584:Nitrogen / Q000627:therapeutic use; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D012492:Salts / Q000627:therapeutic use; D014860:Warts / Q000188:drug therapy* / Q000821:virology
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D004338:Drug Combinations; D012492:Salts; D017942:Nitric Acid; D009584:Nitrogen