title: [The sepsis as cause of acute kidney injury: an experimental model].
abstract: Sepsis associated with multiple organ failure such as acute kidney injury (AKI) shows a high mortality rate in critically ill patients. This study investigated the sepsis induced AKI in experimental models. Adult, males, Wistar rats divided into the following groups: Control-surgical control and Sepsis-sepsis induction for the cecal ligation and puncture (CLP). Physiological parameters (rectal temperature, mean arterial pressure-MAP, serum glucose and urinary flow); renal function (creatinine clearance); oxidative stress (urinary peroxides and thiobarbituric acid reactive substances-TBARS) and kidney histological analysis were evaluated. That study concludes that sepsis induces AKI by endothelial injury with hemodynamic dysfunction, release of inflammatory mediators and reactive oxygen species (ROS) generation by tubular cells, in an association of renal vasoconstriction due to hemodynamic and inflammatory disturbances.
authors.affiliation: Doutoranda da Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Carolina Ferreira
authors.initials: CF
authors.lastname: Pinto
authors.forename: Mirian
authors.initials: M
authors.lastname: Watanabe
authors.forename: Cassiane Dezoti
authors.initials: CD
authors.lastname: da Fonseca
authors.forename: Cecília Ide
authors.initials: CI
authors.lastname: Ogata
authors.forename: Maria de Fátima Fernandes
authors.initials: Mde F
authors.lastname: Vattimo
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000818:Animals; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000150:complications*