title: Evaluation of analgesic activity of P. domestica L.
abstract: This research study was conducted to investigate acute oral toxicity and analgesic activity of ethanol extract of P. domestica fruit by using tail flick analgesiometer at 300 and 500mg/kg doses in animal models. Acute oral toxicity results showed that crude extract is safe up to the dose of 5g/kg body weight of animals. The analgesic activity revealed that P. domestica extract at 500mg/kg dose possesses highest significant and prolonged analgesic activity in dose dependent manner as compared to standard and control groups. Aspirin 300mg/kg body weight was used as standard drug. Phytochemical analysis was also carried out which showed the presence of certain phytochemicals constituents in test drug that are responsible for analgesic activity. Therefore the results are justified.
authors.affiliation: Pharmaceutical Research Centre, PCSIR Labs Complex, Karachi, Pakistan.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Yaqeen
authors.forename: Naimul Hassan
authors.initials: NH
authors.lastname: Naqvi
authors.forename: Hina
authors.initials: H
authors.lastname: Imran
authors.forename: Nudrat
authors.initials: N
authors.lastname: Fatima
authors.forename: Tehmina
authors.initials: T
authors.lastname: Sohail
authors.forename: Zakirur
authors.initials: Z
authors.lastname: Rehman
authors.forename: Atiqur
authors.initials: A
authors.lastname: Rahman
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001241:Aspirin / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D005638:Fruit; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D027861:Prunus / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry; D013997:Time Factors; D023382:Toxicity Tests, Acute
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D001241:Aspirin