title: Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations.
abstract: Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.
authors.affiliation: Department of Mathematics, University of California, Irvine, CA 92697, USA.
authors.forename: Natalia L
authors.initials: NL
authors.lastname: Komarova
authors.forename: Daniela
authors.initials: D
authors.lastname: Anghelina
authors.forename: Igor
authors.initials: I
authors.lastname: Voznesensky
authors.forename: Benjamin
authors.initials: B
authors.lastname: Trinité
authors.forename: David N
authors.initials: DN
authors.lastname: Levy
authors.forename: Dominik
authors.initials: D
authors.lastname: Wodarz
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D005434:Flow Cytometry; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000254:growth & development*; D006801:Humans; D019169:Jurkat Cells; D008954:Models, Biological; D014771:Virion / Q000378:metabolism; D014779:Virus Replication