title: Magnetic resonance imaging-guided percutaneous biopsy of mediastinal masses: diagnostic performance and safety.
abstract: OBJECTIVE
  The objective of this study was to evaluate the diagnostic performance and safety of magnetic resonance (MR) imaging-guided percutaneous mediastinal biopsy procedures using a 0.23-T open MR system with optical tracking navigation.
  
  
  METHODS
  A retrospective analysis of 59 participants (38 males and 21 females; mean age, 45 years; range, 16-73 years) who underwent MR imaging-guided percutaneous mediastinal biopsy procedures was performed. The access techniques included extrapleural (40 of 59; 67.8%) and transpulmonary (19 of 59; 32.2%) needle paths. Tissue sampling techniques included fine-needle aspiration (22 of 59; 37.3%) and core-needle biopsy (37 of 59; 62.7%). Histopathological analysis of surgical specimen and clinical and imaging follow-ups were used as the reference standard. The procedures were evaluated for technical success rate, number of biopsy passes, diagnostic performance, procedure time, and complications.
  
  
  RESULTS
  Technical success was achieved in 57 of the 59 procedures (96.6%). For the fine-needle aspiration, a mean of 3 passes (range, 2-4 passes) was performed. For the core-needle biopsy, a mean of 4 passes (range, 3-6 passes) was performed. Pathological and cytological analysis of biopsy specimens showed 41 of 57 malignant lesions (71.9%) and 16 of 57 benign lesions (28.1%), with a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 93.2% (41 of 44), 100% (13 of 13), 100% (41 of 41), 81.2% (13 of 16), and 94.7% (54 of 57), respectively. Procedure time was 30 minutes (range, 20-50 minutes). Mild hemoptysis occurred in 3 cases, and in 2 cases, a small pneumothorax occurred.
  
  
  CONCLUSIONS
  Magnetic resonance imaging-guided biopsy of mediastinal masses has a high diagnostic performance and is safe for use in clinical practice.
authors.affiliation: Shandong Medical Imaging Research Institute, Shandong University, Jinan, China.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Lü
authors.forename: Jan
authors.initials: J
authors.lastname: Fritz
authors.forename: Chengli
authors.initials: C
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Pearlene
authors.initials: P
authors.lastname: Lee
authors.forename: Lebin
authors.initials: L
authors.lastname: Wu
authors.forename: John A
authors.initials: JA
authors.lastname: Carrino
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006469:Hemoptysis / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D061705:Image-Guided Biopsy / Q000009:adverse effects* / Q000379:methods*; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology*; D008875:Middle Aged; D011030:Pneumothorax / Q000175:diagnosis / Q000209:etiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult