title: MMP-9 -1562C>T contributes to periodontitis susceptibility.
abstract: OBJECTIVE
  The study was conducted to explore the potential association of Matrix metalloproteinases (MMP)-9 -1562C>T with susceptibility to periodontitis.
  
  
  METHODS
  Electronic literature searches of PubMed, EMBASE and EBSCO databases were performed. Fixed-effects or random-effects models were used to calculate the pooled odds ratios (ORs) for four genetic comparisons.
  
  
  RESULTS
  Seven eligible studies with a total of 628 cases and 689 controls were recruited in the pooled analysis. We found MMP-9 -1562C>T contributed to decreased risk of chronic periodontitis. Furthermore, the polymorphism was associated with modified risk of periodontitis among Caucasian populations.
  
  
  CONCLUSIONS
  This study indicated that MP-9 -1562C>T might be involved in the development of periodontitis. A replication of our results in independent large analysis populations is necessary to give evidence to our observation.
authors.affiliation: Institute of Stomatology, Nanjing Medical University, Nanjing, China.
authors.forename: Yongchu
authors.initials: Y
authors.lastname: Pan
authors.forename: Dandan
authors.initials: D
authors.lastname: Li
authors.forename: Qi
authors.initials: Q
authors.lastname: Cai
authors.forename: Weibing
authors.initials: W
authors.lastname: Zhang
authors.forename: Junqing
authors.initials: J
authors.lastname: Ma
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D003596:Cytosine; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D010518:Periodontitis / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D013941:Thymine; D044465:White People
chemical_list: D003596:Cytosine; D020780:Matrix Metalloproteinase 9; D013941:Thymine