title: Scopariusins, a new class of ent-halimane diterpenoids isolated from Isodon scoparius, and biomimetic synthesis of scopariusin A and isoscoparin N.
abstract: Scopariusins A-C (1-3), three novel rearranged ent-halimanoids with a bicycle[5.4.0]undecane ring system, two new normal ent-halimanoids (4 and 5), and a new ent-clerodanoid (6) were isolated from Isodon scoparius. Moreover, a biomimetic transformation from the ent-clerodanoid to the normal and the rearranged ent-halimane diterpenoids was successfully accomplished, which not only validated the biogenetic hypothesis in this plant but also confirmed the absolute configurations of 1 and 5.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Geng
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Dong
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Wang
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Qin
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D004224:Diterpenes; C580799:isoscoparin N; C580800:scopariusin A; C580798:scopariusin B; C580801:scopariusin C