title: [Recurrent breast cancer obtained long-term survival with local treatment(surgery and stereotactic body radiotherapy)and systemic therapy].
abstract: A 52-year-old woman developed right breast cancer and underwent modified radical mastectomy in 1994. Histologically, the tumor was invasive ductal carcinoma. She was positive for estrogen receptor (ER) but negative for progesterone receptor(PgR), while her human epidermal growth factor receptor type 2(HER2) status was not examined. Although she received adjuvant hormone therapy and chemotherapy[cyclophosphamide+doxorubicin+5-fluorouraci(l CAF), 6 courses ], she underwent partial pulmonary resection on both sides with right oophorectomy in 1997. Subsequently, she was treated with weekly doses paclitaxel(12 courses). However, she developed a pulmonary metastasis in the left breast. In 2002, she underwent a partial left pulmonary resection (ER-positive and HER2 3+) and treatment with an aromatase inhibitor. Subsequently, she was treated with trastuzumab because of repeated lung metastasis. A complete response was obtained after the administration of trastuzumab. In 2008, she developed bone metastasis in the sternum and the left seventh rib, and subsequently underwent stereotactic body radiotherapy (SBRT). She was treated with trastuzumab and aromatase inhibitor. At present, she is free of pain and is still living 15 years after breast cancer recurrence. This case suggests that the interaction of local treatment(surgery and SBRT) and systemic therapy(chemotherapy, hormonal therapy, and monoclonal therapy) may improve the survival of patients with recurrent breast cancer.
authors.affiliation: Dept. of Breast and Endocrine Surgery, Kanazawa Medical University Hospital, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Morioka
authors.forename: Yukako
authors.initials: Y
authors.lastname: Ohno
authors.forename: Miki
authors.initials: M
authors.lastname: Noguchi
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nakano
authors.forename: Masakuni
authors.initials: M
authors.lastname: Noguchi
authors.forename: Takeo
authors.initials: T
authors.lastname: Kosaka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takanaka
mesh_terms: D001943:Breast Neoplasms / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D013997:Time Factors