title: Preproghrelin gene polymorphisms in obese Japanese women. Minor homozygotes are light eaters, do not prefer protein or fat, and apparently have a poor appetite.
abstract: Preproghrelin gene single-nucleotide polymorphisms are possible predisposing factors to obesity and other metabolic syndromes. To study the correlation between genotypes and obesity, we recruited 117 obese Japanese women (BMI, 25.0-41.1; average, 31.1). Minor homozygotes for five preproghrelin gene polymorphisms, namely, -1500C>G (rs3755777), -1062G>C (rs26311), -994C>T (rs26312) (promoter region), Leu72Met (rs696217) (exon 2), and +3056T>C (rs2075356) (intron 2), had high values of total and visceral fat areas, waist circumference, and BMI, indicating significant correlation of the polymorphisms with obesity and fat metabolism. Here, we studied the relationship between the genotypes and dietary tendency. Self-administered Diet History Questionnaire showed that total food intake, sugar, and dairy product intake were low in +3056C/C women. Their energy, protein, fat, and meat intake was also low. Energy balance calculation showed considerably reduced fat and protein consumption. Dietary habits were surveyed using Sakata's Questionnaire on Eating Behavior. Of the genotypes, -1062C/C women showed low scores for "motivation for eating" and "eating because of stress or something else." Thus, surprisingly, it was revealed that minor homozygotes for preproghrelin gene polymorphisms were light eaters, did not prefer fat or protein, and apparently had a poor appetite, although they were predisposed to obesity.
authors.affiliation: Division of Nutritional Education, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Takezawa
authors.forename: Kouichi
authors.initials: K
authors.lastname: Yamada
authors.forename: Motohiko
authors.initials: M
authors.lastname: Miyachi
authors.forename: Akemi
authors.initials: A
authors.lastname: Morita
authors.forename: Naomi
authors.initials: N
authors.lastname: Aiba
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sasaki
authors.forename: Shaw
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D005247:Feeding Behavior; D001068:Feeding and Eating Disorders / Q000235:genetics*; D005260:Female; D054439:Ghrelin / Q000235:genetics* / Q000378:metabolism; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011795:Surveys and Questionnaires; D055105:Waist Circumference
chemical_list: D004041:Dietary Fats; D004044:Dietary Proteins; D054439:Ghrelin