title: Overview of human primary tumorgraft models: comparisons with traditional oncology preclinical models and the clinical relevance and utility of primary tumorgrafts in basic and translational oncology research.
abstract: Laboratory models that accurately replicate human tumor initiation and characteristics are integral to advancing knowledge in cancer research. However, comparative studies between commonly employed laboratory models and human tumors have demonstrated that some models have molecular and genomic alterations dissimilar to the cancer type they attempt to replicate. In contrast, several recent comparative studies suggest that because patient-derived tumors grown in mice maintain many of the important characteristics of the original tumor, they represent an important tool for the development of new cancer therapeutics. Detailed in this overview are the advantages and disadvantages of the most commonly used cancer models for mechanistic and therapeutic research, with an emphasis on the advances made in the production and use of patient-derived tumorgrafts.
authors.affiliation: Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Lum
authors.forename: Cindy
authors.initials: C
authors.lastname: Matsen
authors.forename: Alana L
authors.initials: AL
authors.lastname: Welm
authors.forename: Bryan E
authors.initials: BE
authors.lastname: Welm
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D055808:Drug Discovery; D005818:Genetic Engineering; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation / Q000379:methods; D009369:Neoplasms / Q000209:etiology / Q000628:therapy*; D057170:Translational Research, Biomedical; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents