title: Loaded dice for human genome mutation.
abstract: Not all bases in the human genome are equally prone to chance mutations. Michaelson et al. show that individuals can acquire clusters of de novo DNA changes and propose that the likelihood of single base pair change differs across three orders of magnitude.
authors.affiliation: MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3PT, UK. chris.ponting@dpag.ox.ac.uk
authors.forename: Chris P
authors.initials: CP
authors.lastname: Ponting