title: Association between a marker on chromosome 9 and acute coronary syndrome. confirmatory study on Czech population.
abstract: Myocardial infarction (MI) is the leading           cause of death in industrialized countries. All the           classical risk factors for MI are responsible for approximately           50 % of MI cases. Attention has therefore           recently been attracted to those genetic variants           that are not associated with conventional risk factors.           One of them is the marker rs10757274 in the "genefree"           zone on chromosome 9, which has been repeatedly           recognized as a risk factor for development of           MI in Western populations. We analysed the relationship           between the rs10757274 variant on chromosome           9 and risk of the acute coronary syndrome (ACS)           in Czech population. The rs10757274 (A > G) variant           was successfully analysed (CR = 99.4 % for patients           and 98.4 % for controls) by PCR-RFLP in consecutively examined 1,046 men and 281 women with ACS           (age below 65 years) and in population-based controls           - 1,162 men and 1,355 women (aged up to 65 years).           ANOVA and χ2 were used for statistical analysis. We           confirmed that GG homozygotes are more frequent           (codominant model of analysis) among patients with           myocardial infarction than in the control group both           in men (28.5 % vs. 22.0 %, P = 0.0001, OR 1.73, 95 %           CI 1.36-2.19) and women (32.0 % vs. 24.6 %, P = 0.02,           OR 1.62, 95 % CI 1.13-2.34). However, rs10757274           polymorphism was not associated with the classical           risk factors either in control population or in ACS patients.           We conclude that the rs10757274 variant at           9p23.1 is an important genetic risk factor for ACS development           in the Czech population.
authors.affiliation: Institute for Clinical and Experimental Medicine, Prague, Czech Republic. jahb@ikem.cz
authors.forename: J A
authors.initials: JA
authors.lastname: Hubáček
authors.forename: V
authors.initials: V
authors.lastname: Staněk
authors.forename: M
authors.initials: M
authors.lastname: Gebauerová
authors.forename: R
authors.initials: R
authors.lastname: Poledne
authors.forename: M
authors.initials: M
authors.lastname: Aschermann
authors.forename: H
authors.initials: H
authors.lastname: Skalická
authors.forename: J
authors.initials: J
authors.lastname: Matoušková
authors.forename: A
authors.initials: A
authors.lastname: Kruger
authors.forename: M
authors.initials: M
authors.lastname: Pěnička
authors.forename: H
authors.initials: H
authors.lastname: Hrabáková
authors.forename: J
authors.initials: J
authors.lastname: Veselka
authors.forename: P
authors.initials: P
authors.lastname: Hájek
authors.forename: V
authors.initials: V
authors.lastname: Lánská
authors.forename: V
authors.initials: V
authors.lastname: Adámková
authors.forename: J
authors.initials: J
authors.lastname: Pitha
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D018153:Czech Republic; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015203:Reproducibility of Results; D012307:Risk Factors
chemical_list: D005819:Genetic Markers