title: NeutroPhase(®) in chronic non-healing wounds.
abstract: Chronic non-healing wounds, such as venous stasis ulcers, diabetic ulcers, and pressure ulcers are serious unmet medical needs that affect a patient's morbidity and mortality. Common pathogens observed in chronic non-healing wounds are Staphylococcus including MRSA, Pseudomonas, Enterobacter, Stenotrophomonas, and Serratia spp. Topical and systemically administered antibiotics do not adequately decrease the level of bacteria or the associated biofilm in chronic granulating wounds and the use of sub-lethal concentrations of antibiotics can lead to resistant phenotypes. Furthermore, topical antiseptics may not be fully effective and can actually impede wound healing. We show 5 representative examples from our more than 30 clinical case studies using NeutroPhase(®) as an irrigation solution with chronic non-healing wounds with and without the technique of negative pressure wound therapy (NPWT). NeutroPhase(®) is pure 0.01% hypochlorous acid (i.e. >97% relative molar distribution of active chlorine species as HOCl) in a 0.9% saline solution at pH 4-5 and is stored in glass containers. NovaBay has three FDA cleared 510(k)s. Patients showed a profound improvement and marked accelerated rates of wound healing using NeutroPhase(®) with and without NPWT. NeutroPhase(®) was non-toxic to living tissues.
authors.affiliation: Seton Medical Center Daly City, CA 94015.
authors.forename: John
authors.initials: J
authors.lastname: Crew
authors.forename: Randell
authors.initials: R
authors.lastname: Varilla
authors.forename: Thomas Allandale
authors.initials: TA
authors.lastname: Rocas
authors.forename: Dmitri
authors.initials: D
authors.lastname: Debabov
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Azar
authors.initials: A
authors.lastname: Najafi
authors.forename: Suriani Abdul
authors.initials: SA
authors.lastname: Rani
authors.forename: Ramin Ron
authors.initials: RR
authors.lastname: Najafi
authors.forename: Mark
authors.initials: M
authors.lastname: Anderson