title: Anti-glomerular basement membrane glomerulonephritis complicated by thrombocytopenia.
abstract: Rapidly progressive glomerulonephritis (RPGN) is characterized by the rapid deterioration of the renal function associated with crescent formation on renal biopsies. This report describes a case of RPGN caused by anti-glomerular basement membrane (GBM) glomerulonephritis in an elderly man with severe thrombocytopenia and a platelet count of 1.4 × 10(4)/µL. Thrombotic microangiopathy (TMA) and heparin-induced thrombocytopenia (HIT) were implicated in the severe decrease in platelets. This report also discusses the pathological background and clinical management of TMA and HIT among patients with anti-GBM glomerulonephritis.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Miki
authors.forename: Tetsu
authors.initials: T
authors.lastname: Akimoto
authors.forename: Taro
authors.initials: T
authors.lastname: Sugase
authors.forename: Akihiko
authors.initials: A
authors.lastname: Numata
authors.forename: Naoko
authors.initials: N
authors.lastname: Otani
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Iwazu
authors.forename: Eri
authors.initials: E
authors.lastname: Takeshima
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Morishita
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Muto
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusano
mesh_terms: D000368:Aged; D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications*; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000209:etiology*