title: First report of lung transplantation in a patient with active pulmonary Mycobacterium simiae infection.
abstract: Mycobacterium simiae is a slow-growing mycobacteria that in rare cases can cause chronic pulmonary infection. We report the first case of lung transplantation in a patient with active M simiae infection at the time of transplantation. A 56-year-old immunocompetent nonsmoking woman underwent bilateral lung transplantation for end-stage idiopathic bronchiectasis and chronic M simiae infection. The disease proved manageable on a regimen of clarithromycin, moxifloxacin, and cotrimoxazole with a successful outcome 1-year posttransplantation. There is increasing evidence that nontuberculous mycobacterium infection should no longer be an absolute contraindication for lung transplantation.
authors.affiliation: Copenhagen CF Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. tavs.qvist@gmail.com
authors.forename: T
authors.initials: T
authors.lastname: Qvist
authors.forename: T L
authors.initials: TL
authors.lastname: Katzenstein
authors.forename: T
authors.initials: T
authors.lastname: Lillebaek
authors.forename: M
authors.initials: M
authors.lastname: Iversen
authors.forename: L
authors.initials: L
authors.lastname: Mared
authors.forename: A B
authors.initials: AB
authors.lastname: Andersen
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001372:Aza Compounds / Q000627:therapeutic use; D001987:Bronchiectasis / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D002908:Chronic Disease; D017291:Clarithromycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D016040:Lung Transplantation; D008875:Middle Aged; D000077266:Moxifloxacin; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D009170:Nontuberculous Mycobacteria / Q000145:classification / Q000302:isolation & purification*; D011804:Quinolines / Q000627:therapeutic use; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D017291:Clarithromycin; D000077266:Moxifloxacin