title: Importance of ligand structure in DNA/protein binding, mutagenicity, excision repair and nutritional aspects of chromium(III) complexes.
abstract: Chromium is extensively used in leather, chrome plating and refining industries. On one hand the occupational exposure to chromium leads to cancer, whereas on the contrary certain Cr(III) compounds have been proposed as nutritional supplements for Type II diabetes and as muscle building agents. Despite the positive outlook of chromium as a bio-essential element, there is increasing concern over the therapeutic application of Cr(III) based supplements, its bioavailability and toxicity profile. In this perspective, we discuss the role of ligand structure in mediating the interaction of chromium(III) complexes with DNA/protein, their mutagenic outcomes, adduct reparability and as nutritional supplements.
authors.affiliation: Chemical Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research, Adyar, Chennai 600 020, India.
authors.forename: V G
authors.initials: VG
authors.lastname: Vaidyanathan
authors.forename: Yamini
authors.initials: Y
authors.lastname: Asthana
authors.forename: Balachandran Unni
authors.initials: BU
authors.lastname: Nair
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000187:drug effects / Q000235:genetics; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D016466:CHO Cells; D002857:Chromium / Q000009:adverse effects* / Q000737:chemistry / Q000633:toxicity; D006224:Cricetinae; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D004260:DNA Repair / Q000187:drug effects*; D019587:Dietary Supplements; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D016296:Mutagenesis / Q000187:drug effects*; D009942:Organometallic Compounds / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011485:Protein Binding / Q000187:drug effects; D011506:Proteins / Q000737:chemistry* / Q000235:genetics
chemical_list: D000596:Amino Acids; D008024:Ligands; D009942:Organometallic Compounds; D011506:Proteins; D002857:Chromium; D004247:DNA