title: Functionalized magnetite silica thin films fabricated by MAPLE with antibiofilm properties.
abstract: We report on the fabrication of magnetite/salicylic acid/silica shell/antibiotics (Fe(3)O(4)/SA/SiO(2)/ATB) thin films by matrix-assisted pulsed laser evaporation (MAPLE) to inert substrates. Fe(3)O(4)-based powder have been synthesized and investigated by XRD and TEM. All thin films were studied by FTIR, SEM and in vitro biological assays using Staphylococcus aureus and Pseudomonas aeruginosa reference strains, as well as eukaryotic HEp-2 cells. The influence of the obtained nanosystems on the microbial biofilm development as well as their biocompatibility has been assessed. For optimum deposition conditions, we obtained uniform adherent films with the composition identical with the raw materials. Fe(3)O(4)/SA/SiO(2)/ATB thin films had an inhibitory activity on the ability of microbial strains to initiate and develop mature biofilms, in a strain- and antibiotic-dependent manner. These magnetite silica thin films are promising candidates for the development of novel materials designed for the inhibition of medical biofilms formed by different pathogenic agents on common substrates, frequently implicated in the etiology of chronic and hard to treat infections.
authors.affiliation: Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1-7 Polizu Street, Bucharest, Romania.
authors.forename: D E
authors.initials: DE
authors.lastname: Mihaiescu
authors.forename: R
authors.initials: R
authors.lastname: Cristescu
authors.forename: G
authors.initials: G
authors.lastname: Dorcioman
authors.forename: C E
authors.initials: CE
authors.lastname: Popescu
authors.forename: C
authors.initials: C
authors.lastname: Nita
authors.forename: G
authors.initials: G
authors.lastname: Socol
authors.forename: I N
authors.initials: IN
authors.lastname: Mihailescu
authors.forename: A M
authors.initials: AM
authors.lastname: Grumezescu
authors.forename: D
authors.initials: D
authors.lastname: Tamas
authors.forename: M
authors.initials: M
authors.lastname: Enculescu
authors.forename: R F
authors.initials: RF
authors.lastname: Negrea
authors.forename: C
authors.initials: C
authors.lastname: Ghica
authors.forename: C
authors.initials: C
authors.lastname: Chifiriuc
authors.forename: C
authors.initials: C
authors.lastname: Bleotu
authors.forename: D B
authors.initials: DB
authors.lastname: Chrisey
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D007834:Lasers; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000502:physiology*; D012822:Silicon Dioxide / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D012822:Silicon Dioxide