title: Surfactant protein D as a biomarker for chronic obstructive pulmonary disease.
abstract: Clinical research in chronic obstructive pulmonary disease (COPD) has been hampered by the lack of validated blood biomarkers. The ideal COPD biomarker would have the following characteristics: (1) it would be a lung specific protein that could be assayed in blood; (2) it would change with disease severity or during exacerbations; (3) it would be specific for COPD; and would be responsive to change with effective treatments. One such candidate is the lung specific protein surfactant protein D (SP-D). In this review, we discuss the evidence supporting SP-D as a COPD biomarker.
authors.affiliation: Department of Medicine, National Jewish Health, Denver, CO, USA. bowlerr@njhealth.org
authors.forename: Russell P
authors.initials: RP
authors.lastname: Bowler
mesh_terms: D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005819:Genetic Markers; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood* / Q000235:genetics; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D037663:Pulmonary Surfactant-Associated Protein D