title: Serum zinc status and Helicobacter pylori infection in gastric disease patients.
abstract: The role of Helicobacter pylori status and serum zinc value in gastric disease patients and healthy controls were investigated. Cases used in this work were 45 gastric cancer patients, 44 with peptic ulcers, 52 suffering gastritis and 64 healthy controls, all diagnosed histologically with the controls undergoing medical checkups. Helicobacter pylori status and serum levels of Zn were determined by 13C-urea breath test and flame atomic absorption spectrophotometer, respectively. Our study showed that Helicobacter pylori infection has no change in gastritis, peptic ulcer and gastric cancer group, on the contrast, serum levels of Zn were significantly reduced in gastritis, peptic ulcer and gastric cancer group, compared with healthy controls, and the higher the Zn levels are, the more increased risk of gastric cancer. Helicobacter pylori infection is a cause of gastritis, peptic ulcers and even gastric cancer, while serum zinc level is an indicator of protection of gastric membranes against damage.
authors.affiliation: Department of Oncology, 2Institute of Oncology, Tianjin Union Medicine Centre, Tianjin, China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Zhang
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Wu
authors.forename: Jing-Xiu
authors.initials: JX
authors.lastname: Niu
authors.forename: Hao
authors.initials: H
authors.lastname: Yan
authors.forename: Xin-Zhuo
authors.initials: XZ
authors.lastname: Wang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Yin
authors.forename: Yan
authors.initials: Y
authors.lastname: Pang
mesh_terms: D000328:Adult; D001944:Breath Tests; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005756:Gastritis / Q000097:blood / Q000150:complications / Q000821:virology*; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications / Q000821:virology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010437:Peptic Ulcer / Q000097:blood / Q000150:complications / Q000821:virology*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000097:blood / Q000473:pathology / Q000821:virology*; D015032:Zinc / Q000097:blood*
chemical_list: D015032:Zinc