title: Fibronectin gene expression in human adipose tissue and its associations with obesity-related genes and metabolic parameters.
abstract: BACKGROUND
  Limited data are available on the in vivo expression of fibronectin, one of the main extracellular matrix components. We investigated the expression of fibronectin in abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and the associations of leptin, adiponectin, and vaspin gene expression with metabolic parameters in obese women.
  
  
  METHODS
  We recruited female subjects undergoing bariatric surgery for obesity (n = 24) and patients undergoing benign gynecological surgery as the control group (n = 23). We measured anthropometric variables, abdominal fat distribution, metabolic parameters, serum concentrations of leptin, adiponectin, and vaspin, and depot-specific mRNA expression of fibronectin, leptin, adiponectin, and vaspin.
  
  
  RESULTS
  Fibronectin expression in both VAT and SAT was significantly lower in the obese group than in the control group. Fibronectin expression in both VAT and SAT were negatively correlated with body mass index or waist circumference, with higher prominence in VAT. In multiple regression analysis, fibronectin expression in both VAT and SAT was negatively correlated with serum leptin concentration. Fibronectin expression in VAT was negatively correlated with leptin expression in VAT. Additionally, fibronectin expression in SAT was negatively correlated with leptin expression in SAT and positively correlated with adiponectin expression in VAT and SAT.
  
  
  CONCLUSIONS
  We found significant negative associations between depot-specific fibronectin expression in human adipose tissue and obesity indices and obesity-related biomarkers. Our results suggest that fibronectin expression may contribute to obesity and metabolic dysregulation in humans.
authors.affiliation: Department of Family Medicine, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Seoung Hee
authors.initials: SH
authors.lastname: Lee
authors.forename: Hye Soon
authors.initials: HS
authors.lastname: Park
authors.forename: Jung Ah
authors.initials: JA
authors.lastname: Lee
authors.forename: Young Sook
authors.initials: YS
authors.lastname: Song
authors.forename: Yeon Jin
authors.initials: YJ
authors.lastname: Jang
authors.forename: Jong-Hyeok
authors.initials: JH
authors.lastname: Kim
authors.forename: Yeon Ji
authors.initials: YJ
authors.lastname: Lee
authors.forename: Yoonseok
authors.initials: Y
authors.lastname: Heo
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism; D009765:Obesity / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D056910:Republic of Korea / Q000453:epidemiology; D015843:Serpins / Q000378:metabolism*; D050151:Subcutaneous Fat / Q000378:metabolism*; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D005353:Fibronectins; D020738:Leptin; D012333:RNA, Messenger; C507339:SERPINA12 protein, human; D015843:Serpins