title: [Prediction of the efficacy of first-line oxaliplatin-based chemotherapy for unresectable liver metastases of colorectal cancer by Köhne's index].
abstract: OBJECTIVE
  This retrospective study was undertaken to examine the usefulness of Köhne's index(KI) for predicting the efficacy of first-line oxaliplatin-based chemotherapy for unresectable liver metastases of colorectal cancer.
  
  
  METHODS
  The subjects were 84 patients with unresectable liver metastases of colorectal cancer in whom first-line oxaliplatin- based chemotherapy was administered. The outcome of treatment was analyzed in relation to the KI.
  
  
  RESULTS
  The patients were classified into 3 groups: high risk group (n=12), intermediate risk group (n=20), and low risk group (n=52). There were no significant differences between the groups with regard to response rate, disease control rate, disease-free survival, overall survival, and the rate of conversion to hepatic metastatectomy.
  
  
  CONCLUSIONS
  Our results suggest that KI might not be useful for predicting the efficacy of first-line oxaliplatin-based chemotherapy for unresectable liver metastases of colorectal cancer.
authors.affiliation: Dept. of Digestive Tract and General Surgery, Saitama Medical University, Japan.
authors.forename: Norimichi
authors.initials: N
authors.lastname: Okada
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ohsawa
authors.forename: Jun
authors.initials: J
authors.lastname: Sobajima
authors.forename: Kouki
authors.initials: K
authors.lastname: Kuwabara
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Amano
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hatano
authors.forename: Okihide
authors.initials: O
authors.lastname: Suzuki
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kumamoto
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kumagai
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Baba
authors.forename: Norihiro
authors.initials: N
authors.lastname: Haga
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ishida
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D000077150:Oxaliplatin; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin