title: Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factors.
abstract: BACKGROUND
  Atopic dermatitis (AD) is commonly associated with asthma and other atopic disorders in childhood.
  
  
  OBJECTIVE
  To evaluate the natural history of AD and its association with other allergic outcomes in a high-risk cohort through the age of 7 years.
  
  
  METHODS
  A total of 373 high-risk infants, who had undergone a randomized controlled trial with intervention measures for primary prevention of asthma applied during the first year of life, were assessed for asthma, AD, and allergic sensitization at 1, 2, and 7 years.
  
  
  RESULTS
  The multifaceted intervention program did not reduce AD despite reducing the prevalence of asthma significantly. Sixty-two children (16.6%) had AD during the first 2 years (early-onset AD); of these, 26 continue to have AD at the age of 7 years (persistent), whereas 36 no longer had the disease (nonpersistent) at the age of 7 years. Twenty-three children (6.2%) developed AD only after the age of 2 years (late-onset AD). Early-onset AD, persistent or nonpersistent, was associated with increased risk of allergic sensitization to food allergens within the first 2 years of life and asthma diagnosis at year 7. However, only persistent AD was associated with an increased risk of other atopic diseases and allergic sensitization to food and aeroallergens at year 7. Late-onset AD was not associated with atopic diseases or allergic sensitization at year 7 with the exception of Alternaria alternans.
  
  
  CONCLUSIONS
  In this cohort of infants at high risk of asthma, early-onset persistent AD, which was highly associated with atopic sensitization, increased the risk of atopic diseases in later childhood and thus appears to be part of the atopic march.
authors.affiliation: Chan-Yeung Centre for Occupational and Environmental Lung Disease Unit, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. carlsten@mail.ubc.ca
authors.forename: Chris
authors.initials: C
authors.lastname: Carlsten
authors.forename: Helen
authors.initials: H
authors.lastname: Dimich-Ward
authors.forename: Alexander
authors.initials: A
authors.lastname: Ferguson
authors.forename: Wade
authors.initials: W
authors.lastname: Watson
authors.forename: Roxanne
authors.initials: R
authors.lastname: Rousseau
authors.forename: Anne
authors.initials: A
authors.lastname: Dybuncio
authors.forename: Allan
authors.initials: A
authors.lastname: Becker
authors.forename: Moira
authors.initials: M
authors.lastname: Chan-Yeung
mesh_terms: D000367:Age Factors; D001249:Asthma / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003876:Dermatitis, Atopic / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D012307:Risk Factors