title: Plasma visfatin, associated with a genetic polymorphism -1535C>T, is correlated with C-reactive protein in Chinese Han patients with traumatic brain injury.
abstract: Visfatin is a newly identified pro-inflammatory adipokine and a genetic polymorphism -1535 C>T located in the visfatin gene promoter has been suggested to be associated with the regulation of visfatin expression in some inflammatory illness. However, there were some conflicting results regarding whether this variant is functional or not. This study aimed to examine the relations of the -1535 C>T single nucleotide polymorphism (SNP) of visfatin gene to the plasma visfatin and C-reactive protein concentrations in traumatic brain injury (TBI). 318 Chinese Han patients with TBI were recruited in this study. Plasma visfatin and C-reactive protein levels were significantly different between the genotypes in the SNP-1535 C>T even after adjustment for age, sex and body mass index. The genotype C-C had the highest plasma visfatin and C-reactive protein concentrations. The plasma visfatin and C-reactive protein concentrations between the variant genotypes C-T and T-T did not differ significantly. Plasma visfatin level was significantly associated with plasma C-reactive protein level using multivariate linear regression. Thus, the SNP-1535 C>T of visfatin gene seemed to be potentially involved in the inflammatory component of TBI through a decreased production of visfatin.
authors.affiliation: Department of Neurosurgery, the Second People's Hospital of Cixi City, Cixi 315315, China.
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Weng
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Wei-Cong
authors.initials: WC
authors.lastname: Hong
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Luo
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Shi-Da
authors.initials: SD
authors.lastname: Luo
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D002097:C-Reactive Protein / Q000096:biosynthesis / Q000235:genetics*; D002681:China; D005260:Female; D005786:Gene Expression Regulation; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D002097:C-Reactive Protein; D054409:Nicotinamide Phosphoribosyltransferase