title: Quercetin modulates Na(+)/K(+) ATPase and sodium hydrogen exchanger in type 2 diabetic erythrocytes.
abstract: Quercetin has been reported to possess many important biological properties. We undertook in vitro studies to examine the effect of quercetin on erythrocyte Na(+)/K(+) ATPase and sodium hydrogen exchanger (NHE) activity in normal and type 2 diabetic subjects. A significant (p<0.02) increase in the activities of Na(+)/K(+) ATPase and a decrease (p< 0.01) in NHE were observed in type 2 diabetic subjects compared to normal. In vitro treatment with quercetin caused inhibition of both Na(+)/K(+) ATPase and NHE. The inhibitory effect of quercetin was concentration dependent. The effect of quercetin on Na(+)/K(+) ATPase and NHE may be explained due to a direct effect of this compound on plasma membrane leading to a change in membrane fluidity. The data obtained in this study may help to explain the anti—diabetic and anti—carcinogenic role of quercetin.
authors.affiliation: Centre of Food Technology, University of Allahabad, Allahabad 211002, India.
authors.forename: N
authors.initials: N
authors.lastname: Mishra
authors.forename: S I
authors.initials: SI
authors.lastname: Rizvi
mesh_terms: D002478:Cells, Cultured; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015394:Molecular Structure; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology*; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D017923:Sodium-Hydrogen Exchangers; D011794:Quercetin; D000254:Sodium-Potassium-Exchanging ATPase