title: Influence of perinatal nutrition and gestational age on neurodevelopment of very low-birth-weight preterm infants.
abstract: OBJECTIVE
  To assess the influence of gestational age and perinatal nutrition on development at 24 months' corrected age in a cohort of very low-birth-weight preterm infants.
  
  
  METHODS
  One hundred twenty-five very low-birth-weight preterm infants admitted to a neonatal intensive care unit within the first 48 hours of life were studied. The infants were classified as born small for gestational age (SGA) and still SGA at discharge (SGA/SGA); born adequate for gestational age (AGA) and SGA at discharge (AGA/SGA); and born AGA and still AGA age at discharge (AGA/AGA). The Bayley Scales of Infant and Toddler Development III (BSID-III) were used for assessment of neurodevelopment at 24 months' corrected age.
  
  
  RESULTS
  Fifty-six infants were classified as SGA/SGA, 55 as AGA/SGA, and 14 as AGA/AGA with no difference in BSID-III among the groups. By multiple linear regression analysis, the variables associated to better neurodevelopment outcome were higher gestational age and absence of grade III/IV periventricular/intraventricular hemorrhage.
  
  
  CONCLUSIONS
  Immaturity is the most important variable associated with better neurodevelopment outcome in very preterm infants.
authors.affiliation: Department of Pediatrics, Newborn Section, Universidade Federal do Rio Grande do Sul and Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Gabriela R
authors.initials: GR
authors.lastname: Filipouski
authors.forename: Rita C
authors.initials: RC
authors.lastname: Silveira
authors.forename: Renato S
authors.initials: RS
authors.lastname: Procianoy
mesh_terms: D000704:Analysis of Variance; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D008895:Milk, Human; D009483:Neuropsychological Tests; D010288:Parenteral Nutrition; D011247:Pregnancy; D011446:Prospective Studies; D012044:Regression Analysis