title: Impact of restricted maternal weight gain on fetal growth and perinatal morbidity in obese women with type 2 diabetes.
abstract: OBJECTIVE
  Since January 2008, obese women with type 2 diabetes were advised to gain 0-5 kg during pregnancy. The aim with this study was to evaluate fetal growth and perinatal morbidity in relation to gestational weight gain in these women.
  
  
  METHODS
  A retrospective cohort comprised the records of 58 singleton pregnancies in obese women (BMI ≥30 kg/m(2)) with type 2 diabetes giving birth between 2008 and 2011. Birth weight was evaluated by SD z score to adjust for gestational age and sex.
  
  
  RESULTS
  Seventeen women (29%) gained ≤5 kg, and the remaining 41 gained >5 kg. The median (range) gestational weight gains were 3.7 kg (-4.7 to 5 kg) and 12.1 kg (5.5-25.5 kg), respectively. Prepregnancy BMI was 33.5 kg/m(2) (30-53 kg/m(2)) vs. 36.8 kg/m(2) (30-48 kg/m(2)), P = 0.037, and median HbA1c was 6.7% at first visit in both groups and decreased to 5.7 and 6.0%, P = 0.620, in late pregnancy, respectively. Gestational weight gain ≤5 kg was associated with lower birth weight z score (P = 0.008), lower rates of large-for-gestational-age (LGA) infants (12 vs. 39%, P = 0.041), delivery closer to term (268 vs. 262 days, P = 0.039), and less perinatal morbidity (35 vs. 71%, P = 0.024) compared with pregnancies with maternal weight gain >5 kg.
  
  
  CONCLUSIONS
  In this pilot study in obese women with type 2 diabetes, maternal gestational weight gain ≤5 kg was associated with a more proportionate birth weight and less perinatal morbidity.
authors.affiliation: Center for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark. bjorga@gmail.com
authors.forename: Björg
authors.initials: B
authors.lastname: Asbjörnsdóttir
authors.forename: Signe S
authors.initials: SS
authors.lastname: Rasmussen
authors.forename: Louise
authors.initials: L
authors.lastname: Kelstrup
authors.forename: Peter
authors.initials: P
authors.lastname: Damm
authors.forename: Elisabeth R
authors.initials: ER
authors.lastname: Mathiesen
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D011247:Pregnancy; D012189:Retrospective Studies; D015430:Weight Gain / Q000502:physiology*; D055815:Young Adult