title: Incidence of second hip fracture and compliant use of bisphosphonate.
abstract: We determined the incidence of second hip fracture and evaluated whether compliant users of bisphosphonate had a lower incidence of second hip fracture after prior hip fracture.
  
  
  BACKGROUND
  Bisphosphonate has been used to prevent osteoporotic fracture and is recommended for the secondary prevention after hip fracture. However, little is known regarding secondary prevention after first hip fracture. Our purpose was to determine the incidence of second hip fracture and to evaluate whether compliant use of bisphosphonate can reduce the risk of second hip fracture.
  
  
  METHODS
  Eight hundred twenty-six patients who sustained the first hip fracture from May 2003 to October 2011 were retrospectively evaluated. The incidence of second hip fracture was compared between compliant users of bisphosphonate and nonusers.
  
  
  RESULTS
  Seventy-one (8.6 %) patients suffered a second hip fracture at mean 30.0 months (SD 24.6, range 1 to 90 months) after the initial hip fracture. The cumulative incidence of second hip fracture was 5.1 % (42/826) at 2 years and 8.6 % (71/826) at 8 years. The incidence of second hip fracture was 4.2 % (12/283) in compliant users and 10.9 % (59/543) in nonusers (p = 0.001).
  
  
  CONCLUSIONS
  Compliant use of bisphosphonate is effective in the prevention of second hip fractures.
authors.affiliation: Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam 463-707, South Korea.
authors.forename: Y-K
authors.initials: YK
authors.lastname: Lee
authors.forename: Y-C
authors.initials: YC
authors.lastname: Ha
authors.forename: B-H
authors.initials: BH
authors.lastname: Yoon
authors.forename: K-H
authors.initials: KH
authors.lastname: Koo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D004341:Drug Evaluation / Q000379:methods; D005260:Female; D006620:Hip Fractures / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy; D058866:Osteoporotic Fractures / Q000517:prevention & control*; D056910:Republic of Korea; D012189:Retrospective Studies; D055502:Secondary Prevention; D016019:Survival Analysis
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates