title: Diterpenoids and sesquiterpenoids from the twigs and leaves of Illicium majus.
abstract: Four new abietane diterpenes (1-4) and two new cycloparvifloralone-type sesquiterpenoids (5-6) have been isolated from the twigs and leaves of Illicium majus, together with three known sesquiterpenoids and five known diterpenoids. Their structures were determined by spectroscopic analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 2 is confirmed by Snatzke's method, observing the induced circular dichroism after the addition of dimolybdenum tetraacetate in DMSO. Compound 2 exihibited significant anti-inflammatory activity with an IC50 value of 0.26 ± 0.03 µM, while compounds 10, 11, and 13 showed good anti-inflammatory activities with IC50 values ranging from 1.94 ± 0.56 to 2.60 ± 0.48 µM.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Zhen-Feng
authors.initials: ZF
authors.lastname: Fang
authors.forename: Gui-Jie
authors.initials: GJ
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Bai
authors.forename: Shi-Shan
authors.initials: SS
authors.lastname: Yu
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Wang
authors.forename: Shuang-Gang
authors.initials: SG
authors.lastname: Ma
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Song
authors.initials: S
authors.lastname: Xu
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002681:China; D002942:Circular Dichroism; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D029523:Illicium / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D009942:Organometallic Compounds; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D045784:Abietanes; D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D009942:Organometallic Compounds; D012717:Sesquiterpenes; C437387:dimolybdenum tetraacetate