title: Bone remodelling in inflammatory arthritis.
abstract: The inflammatory arthropathies that include rheumatoid arthritis, the seronegative spondyloarthropathies and systemic lupus erythematosus are characterised by marked alterations in the architecture and structural integrity of peri-articular bone; however, the pattern and natural history of the skeletal changes differs in these conditions. In part, this can be attributed to differences in the primary anatomical site of the inflammation, but also there is evidence that there are differences in the biological properties and products produced by inflammatory tissues. This review will focus on recent advances in the understanding of the cellular and molecular mechanisms that contribute to the differential pattern of articular bone remodelling in these prototypical inflammatory forms of arthritis.
authors.affiliation: Research Division, Department of Medicine, Hospital for Special Surgery, Weill Cornell Medical College, 535 East 70th Street, New York, NY 10128, USA. goldrings@hss.edu
authors.forename: Steven R
authors.initials: SR
authors.lastname: Goldring
authors.forename: P Edward
authors.initials: PE
authors.lastname: Purdue
authors.forename: Tania N
authors.initials: TN
authors.lastname: Crotti
authors.forename: Zhenxin
authors.initials: Z
authors.lastname: Shen
authors.forename: Merrilee R
authors.initials: MR
authors.lastname: Flannery
authors.forename: Nikolaus B
authors.initials: NB
authors.lastname: Binder
authors.forename: F Patrick
authors.initials: FP
authors.lastname: Ross
authors.forename: Kevin P
authors.initials: KP
authors.lastname: McHugh
mesh_terms: D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D016723:Bone Remodeling / Q000502:physiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D010010:Osteoclasts / Q000502:physiology; D025242:Spondylarthropathies / Q000503:physiopathology*