title: [Effect of different doses of perindopril on myocardial energy expenditure in patients with heart failure following myocardial infarction].
abstract: OBJECTIVE
  To investigate the changes of myocardial energy expenditure in patients with heart failure following myocardial infarction after treatment with different doses of perindopril.
  
  
  METHODS
  Sixty-three patients with heart failure after myocardial infarction were treated with perindopril for 12 months at the doses of 4 mg (group N) and 8 mg (group H). Doppler imaging was used to measure the structural and systolic functional parameters before and after the treatment, and the circumferential end-systolic wall stress (cESS) and myocardial energy expenditure (MEE) were calculated. The biochemical indicators including serum creatinine and plasma NT-proBNP were detected before and after the treatment.
  
  
  RESULTS
  The two groups had similar measurements before treatment. After 12 months of perindopril treatment, the patients in group N showed higher LA, LV, RA, RV, LVIDs, AD, cESS, lgNT-proBNP, and MEE with lower LVFS and LVEF than those in group H. Compared to those before treatment, LVFS and LVEF were increased and LA, LV, RA, RV, AD, LVIDs, LVMI, lgNT-proBNP and MEEm lowered after the 12-month treatment in group H. Significant changes were also found in the measured parameters except for PWTs, LVET, LVSV and LVFS in group N after the treatment. Bivariate analysis showed a significant positive correlation between MEE and lgNT-proBNP (r=0.513, P<0.01).
  
  
  CONCLUSIONS
  A 12-month treatment with perindopril can suppress myocardial remodeling, improve left ventricular systolic function, and lower NT-proBNP and myocardial energy expenditure in patients with heart failure after myocardial infarction, and a higher dose can produce better results.
authors.affiliation: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515,China. ljqwqq@126.com
authors.forename: Jianqiu
authors.initials: J
authors.lastname: Liang
authors.forename: Shuchang
authors.initials: S
authors.lastname: Bai
authors.forename: Dingli
authors.initials: D
authors.lastname: Xu
authors.forename: Zhou
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D000368:Aged; D004734:Energy Metabolism; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy; D009206:Myocardium / Q000378:metabolism; D020913:Perindopril / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
chemical_list: D020913:Perindopril