title: [Research progress in biological basis of cold and heat essence of Chinese medicine].
abstract: Cold-heat problem is one core of traditional Chinese medicine theory. This paper summarizes the experimental research related to the biological basis of cold-heat essence in cold-heat syndrome, cold-heat body constitution and cold-heat property of Chinese herbs. In view of the classical physiological and biochemical indices, gene expression, protein expression and metabolic differences, differences in cold-heat syndrome or cold-heat constitution are mainly based on neurotransmitter, thyroid function, sex hormone, cyclic nucleotide system, and energy metabolism relating to the corresponding gene and protein expression. Furthermore, this paper analyses the change of correlation indices that accompany with a dynamic development process of "constitution-syndrome-herbal intervention", implying that the research of biological basis of cold-heat essence has turned from single index to multiple indices, and from dispersion research to system research.
authors.affiliation: Teaching and Experiment Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Yin
authors.forename: Xiao-Wan
authors.initials: XW
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Dong
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Shi
mesh_terms: D004365:Drugs, Chinese Herbal; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy
chemical_list: D004365:Drugs, Chinese Herbal