title: Placentomegaly and placental mesenchymal dysplasia.
abstract: A 23-year-old primigravida presented to the labour ward at 37 weeks gestation referred with intrauterine growth restriction, oligohydramnios and placentomegaly. Differential diagnoses of placentomegaly were considered. Her antenatal blood screening tests were normal. There were no fetal malformations. However, triple screen and fetal karyotype were not done as patient presented late in pregnancy. The patient soon went into spontaneous labour and delivered a girl weighing 2.15 kg with a normal Apgar score. The cord was long and twisted; placenta was bulky, 1.7 kg, with prominent grape-like vesicles involving whole placenta with a rim of normal placenta at the periphery. Microscopy showed some areas of multiple villi with marked hydropic changes and myxoid degeneration, preserved vasculature and no trophoblastic proliferation. Placental mesenchymal dysplasia was thus diagnosed. The baby had no evidence of Beckwith-Wiedemann syndrome. The child is now 3 years old with normal development and is doing well.
authors.affiliation: Department of Obstetrics & Gynecology, PGIMER, Chandigar,  India.
authors.forename: Minakshi
authors.initials: M
authors.lastname: Rohilla
authors.forename: Sujata
authors.initials: S
authors.lastname: Siwatch
authors.forename: Vanita
authors.initials: V
authors.lastname: Jain
authors.forename: Raje
authors.initials: R
authors.lastname: Nijhawan
mesh_terms: D005260:Female; D006801:Humans; D010922:Placenta Diseases / Q000473:pathology* / Q000601:surgery; D011247:Pregnancy; D055815:Young Adult