title: [Chemotherapy-mediated tumor regression in a patient with stage IV stomach small cell cancer].
abstract: Gastrointestinal tract endoscopy revealed the presence of a 5-cm-diameter type 3 tumor in the cardiac portion of the stomach. The tumor was chromogranin positive, and stomach small cell cancer was diagnosed by immunostaining and biopsy pathology. S-1+CDDP therapy was administered as the first-line treatment. A switch to S-1 monotherapy was made after the patient experienced grade 4 hyponatremia. However, following 7 courses of therapy the disease had progressed. Second-line chemotherapy of CPT-11+CDDP was initiated and after 2 courses the disease stabilized.
authors.affiliation: Dept. of Surgery, Minoh City Hospital.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Nagase
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Makari
authors.forename: Shohei
authors.initials: S
authors.lastname: Iijima
authors.forename: Takuya
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Masaaki
authors.initials: M
authors.lastname: Miyo
authors.forename: Takashi
authors.initials: T
authors.lastname: Doi
authors.forename: Minako
authors.initials: M
authors.lastname: Hoshi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miyake
authors.forename: Satoshi
authors.initials: S
authors.lastname: Oshima
authors.forename: Kimimasa
authors.initials: K
authors.lastname: Ikeda
authors.forename: Eiji
authors.initials: E
authors.lastname: Kurokawa
authors.forename: Nobuteru
authors.initials: N
authors.lastname: Kikkawa
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D006801:Humans; D000077146:Irinotecan; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin