title: [Improvement of symptoms in mild hyperthyroidism with an extract of Lycopus europaeus (Thyreogutt® mono)].
abstract: OBJECTIVE
  Extracts of Lycopus europaeus are used clinically for the control of vegetative and irritative symptoms in mild hyperthyroidism. This study assessed the effects and safety of an extract of Lycopus europaeus (Thyreogutt® mono tablets or drops) in a general practice setting.
  
  
  METHODS
  The study was conducted as an open post-marketing surveillance study consisting of three cohorts, i.e. a prolective assessment in patients receiving Thyreogutt® mono for 4 weeks, a retrolective documentation of data from patients who had received at least one course (4 weeks) of Thyreogutt® mono therapy during the previous 2 years, and a control cohort receiving no drug treatment. Assessments comprised symptoms of mild hyperthyroidism, laboratory tests of thyroid function and adverse events surveillance. Response was defined as normal thyroid hormone values at the end of therapy or a reduction of at least 20% in the number of symptoms after treatment. Responder rates were calculated.
  
  
  RESULTS
  Four hundred and three patients with mild symptomatic hyperthyroidism were observed. The prolective assessment included 146 patients, the retrolective assessment 171 patients, and the control cohort 86 untreated patients. The responder rate was 72.6% in the prolective assessment and 96.5% in the retrolective assessment whereas the responder rate in the untreated control cohort amounted to 41.2%. No adverse events were reported.
  
  
  CONCLUSIONS
  The extract of Lycopus europaeus was well tolerated and associated with a statistically significant and clinically relevant improvement of the symptoms in mild hyperthyroidism. The improvement was markedly better in both Thyreogutt® mono cohorts than in the control cohort.
authors.affiliation: Hausarztzentrum Bocholderstraße, Bocholder Str. 179, 45355 Essen, Deutschland.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Eiling
authors.forename: Veronika
authors.initials: V
authors.lastname: Wieland
authors.forename: Michael
authors.initials: M
authors.lastname: Niestroj
mesh_terms: D000203:Activities of Daily Living / Q000145:classification; D000284:Administration, Oral; D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011358:Product Surveillance, Postmarketing; D011788:Quality of Life; D013960:Thyroid Function Tests
chemical_list: D013956:Antithyroid Agents; D010936:Plant Extracts; C583534:Thyreogutt mono