title: Prevalence of current, 12-month and lifetime major depressive disorder among patients with systemic sclerosis.
abstract: OBJECTIVE
  Patients with SSc experience a range of problems affecting their quality of life, but only one small study has assessed the prevalence of major depressive disorder (MDD) in SSc. The objectives of this study were: (i) to assess the prevalence of current (30-day), 12-month and lifetime MDD in a large sample of Canadian SSc patients; and (ii) to investigate socio-demographic and disease factors associated with 12-month MDD.
  
  
  METHODS
  SSc patients were recruited from seven Canadian Scleroderma Research Group Registry sites (April 2009 to May 2012). MDD and history of a prior depression episode (major or minor) were assessed with the Composite International Diagnostic Interview.
  
  
  RESULTS
  Among 345 patients, prevalence of 30-day, 12-month and lifetime MDD was 3.8% (95% CI 2.2%, 6.3%; n = 13), 10.7% (95% CI 7.9%, 14.4%; n = 37) and 22.9% (95% CI 18.8%, 27.6%; n = 79), respectively. Patients with 12-month MDD had more severe gastrointestinal track involvement than patients without 12-month MDD, but there were no other significant differences on socio-demographic or disease variables. Among patients with 12-month MDD, 81.1% (95% CI 65.8%, 90.3%) reported a prior depression episode compared with 3.9% (95% CI 2.2%, 6.7%) among patients without 12-month MDD (P < 0.01).
  
  
  CONCLUSIONS
  The prevalence of 30-day, 12-month and lifetime MDD among Canadian SSc patients is approximately twice that of the Canadian general population and somewhat higher than in arthritis. SSc patients face a range of psychosocial problems and may benefit from a broad supportive care approach.
authors.affiliation: Department of Educational and Counselling Psychology, McGill University, Montréal, Québec, Canada.
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Jewett
authors.forename: Ilya
authors.initials: I
authors.lastname: Razykov
authors.forename: Marie
authors.initials: M
authors.lastname: Hudson
authors.forename: Murray
authors.initials: M
authors.lastname: Baron
authors.forename: Brett D
authors.initials: BD
authors.lastname: Thombs
mesh_terms: D000368:Aged; D002170:Canada / Q000453:epidemiology; D003866:Depressive Disorder / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012042:Registries; D012595:Scleroderma, Systemic / Q000453:epidemiology*; D012959:Socioeconomic Factors; D013997:Time Factors