title: Accurate dialysis dose evaluation and extrapolation algorithms during online optical dialysis monitoring.
abstract: The aim of this study was to propose an improved method for accurate dialysis dose evaluation and extrapolation by means of Kt/ V from online UV-absorbance measurements for real time and continuous treatment monitoring. The study included a total of 24 treatments from ten uremic patients, seven of whom were male and three females. All patients were on chronic thrice-weekly hemodialysis therapy. The study included both stable and unstable treatments. A known signal processing algorithm, Levenberg-Marquardt, and the newly developed SMART were utilized for the removal of disturbances not relevant for dialysis dose evaluation. Finally, the results were compared with the Kt/ V values based on the blood samples. The new data processing algorithm, SMART, removes disturbances, helps estimate the online Kt/ V with significant precision increase and without any time delay, and more effectively predicts the end Kt/ V for the treatment than the known algorithms.
authors.affiliation: Department of Biomedical Engineering, Technomedicum, Tallinn University of Technology, 19086 Tallinn, Estonia. ivo@cb.ttu.ee
authors.forename: Ivo
authors.initials: I
authors.lastname: Fridolin
authors.forename: Deniss
authors.initials: D
authors.lastname: Karai
authors.forename: Sergei
authors.initials: S
authors.lastname: Kostin
authors.forename: Raimund
authors.initials: R
authors.lastname: Ubar
mesh_terms: D000368:Aged; D000465:Algorithms; D001698:Biomedical Engineering; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D006435:Renal Dialysis; D012815:Signal Processing, Computer-Assisted; D013056:Spectrophotometry, Ultraviolet; D014508:Urea / Q000097:blood; D014511:Uremia / Q000628:therapy
chemical_list: D014508:Urea