title: Evaluation of soluble mesothelin-related peptide as a diagnostic marker of malignant pleural mesothelioma effusions: its contribution to cytology.
abstract: Soluble mesothelin-related peptide (SMRP) is regarded as an FDA approved biomarker for the diagnosis and monitoring of pleural malignant mesothelioma (MPM). We detected the SMRP levels in pleural effusions (PE) by means of an ELISA and analyzed their diagnostic relevance to differentiate MPM from benign pathology and from non-MPM pleural metastasis. Comparison with cytology in MPM-PE was also performed. We found that SMRP detection in MPM-PE can help the diagnosis of MPM and provide additional diagnostic value to cytology. We concluded that SMRP test may be incorporated into clinical practice of PE from patients suspicious for MPM.
authors.affiliation: Division of Pneumology, La Spezia, Italy.
authors.forename: Pier Aldo
authors.initials: PA
authors.lastname: Canessa
authors.forename: Maria Cristiana
authors.initials: MC
authors.lastname: Franceschini
authors.forename: Paola
authors.initials: P
authors.lastname: Ferro
authors.forename: Enrico
authors.initials: E
authors.lastname: Battolla
authors.forename: Paolo
authors.initials: P
authors.lastname: Dessanti
authors.forename: Carmen
authors.initials: C
authors.lastname: Manta
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Sivori
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pezzi
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Fontana
authors.forename: Franco
authors.initials: F
authors.lastname: Fedeli
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Pistillo
authors.forename: Silvio
authors.initials: S
authors.lastname: Roncella
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003581:Cytodiagnosis / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D058851:GPI-Linked Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D000090204:Mesothelin; D008654:Mesothelioma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism; D016066:Pleural Effusion, Malignant / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D010455:Peptides; D000090204:Mesothelin