title: Acid-base transporters modulate cell migration, growth and proliferation: Implications for structure development and remodeling of resistance arteries?
abstract: Disturbed acid-base transport across the plasma membrane affects intracellular pH control and has been shown--primarily based on studies with non-vascular cells--to interfere with a number of fundamental cell functions including cell migration, growth and proliferation. Here, we evaluate the effects of acid-base transport and intracellular pH on the morphology of the resistance artery wall, which is altered in a number of physiological and pathological conditions and is an independent predictor of cardiovascular risk. The current evidence supports that disturbed function and/or expression of acid-base transporters can alter resistance artery morphology--and potentially atherosclerosis-prone conduit arteries--and hence should be considered as possible mechanistic components and targets for treatment in cardiovascular disease. More experimental evidence is required, however, to evaluate the cell biological effects of acid-base transport in vascular cells, the roles of specific acid-base transporters in artery remodeling, the relative mechanistic importance of acid-base transporters in the vascular wall compared to other organs, and the therapeutic potential of modifying acid-base transport activity pharmacologically or genetically.
authors.affiliation: Department of Biomedicine, Aarhus University, Denmark. eb@fi.au.dk
authors.forename: Ebbe
authors.initials: E
authors.lastname: Boedtkjer
authors.forename: Christian
authors.initials: C
authors.lastname: Aalkjaer
mesh_terms: D000136:Acid-Base Equilibrium; D000818:Animals; D001158:Arteries / Q000254:growth & development / Q000378:metabolism* / Q000473:pathology; D002465:Cell Movement; D049109:Cell Proliferation; D002470:Cell Survival; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006984:Hypertrophy; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D018919:Neovascularization, Physiologic; D014655:Vascular Resistance
chemical_list: D026901:Membrane Transport Proteins