title: Animal models of nephrotic syndrome.
abstract: Animal models of proteinuria and nephrotic syndrome are essential tools for studying the mechanisms of action of abnormalities in individual components of the podocyte and glomerular basement membrane. In recent years a variety of in vivo models have been developed to elucidate the function of specific podocyte proteins and their role in the pathogenesis of proteinuria and glomerulosclerosis. In this overview of the animal models currently available we discuss their contribution to our mechanistic understanding and their potential use in screening for novel targeted therapies of steroid-resistant nephrotic syndrome.
authors.affiliation: Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, 69120, Heidelberg, Germany.
authors.forename: Ivana
authors.initials: I
authors.lastname: Simic
authors.forename: Mansoureh
authors.initials: M
authors.lastname: Tabatabaeifar
authors.forename: Franz
authors.initials: F
authors.lastname: Schaefer
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D019276:Glycocalyx / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000601:surgery; D008070:Lipopolysaccharides; D051379:Mice; D008817:Mice, Mutant Strains; D009404:Nephrotic Syndrome / Q000235:genetics / Q000503:physiopathology*; D050199:Podocytes / Q000473:pathology; D011507:Proteinuria / Q000209:etiology; D015027:Zebrafish
chemical_list: D008070:Lipopolysaccharides