title: Deletion polymorphism at chromosome 3q26.1 and oral squamous cell carcinoma.
abstract: Several recent studies have investigated DNA instability in malignancies             including deletions and duplications of part of the chromosome using array-based             comparative genomic hybridization (CGH) analysis. Using the same approach on oral             squamous cell carcinoma (OSCC) tissue samples, we found a frequent deletion at             chromosome 3q26.1 in OSCC patients; this polymorphism showed a gene frequency             of 0.293-0.368 in healthy volunteers (n=60) and 0.129-0.195 in OSCC patients (n=54).             Detailed analysis around the polymorphic region revealed the deletion breakage             point. A significant association of gene frequency for the deletion polymorphism             between healthy volunteers and patients implicated genetic factors related to             this polymorphism in the development of OSCC. Currently, no gene is predicted             to lie within the 3,606-kbp region around the polymorphism. Thus, although a single-gene             model could not explain the occurrence of OSCC, we believe that examining this             polymorphism could be useful in identifying risk factors for OSCC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Tokyo Dental College,                     Tokyo, Japan.
authors.forename: Homare
authors.initials: H
authors.lastname: Kawachi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sugahara
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Akira
authors.initials: A
authors.lastname: Katakura
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Minaguchi
authors.forename: Takahiko
authors.initials: T
authors.lastname: Shibahara
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D019457:Chromosome Breakage; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D055028:Comparative Genomic Hybridization; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic