title: Renal cell carcinoma and systemic onset juvenile idiopathic arthritis.
abstract: Renal cell carcinoma (RCC) accounts for majority of malignancies arising out of the kidney. Paraneoplastic rheumatologic manifestations; myositis, vasculitis, and arthritis have been described in a few cases with RCC. Systemic onset juvenile idiopathic arthritis (JIA) is characterized by intermittent fever, arthritis, reticulo-endothelial cell hyperplasia and absence of rheumatoid factor and antinuclear antibodies. Herein, we report a 16-year-old boy with systemic onset JIA for 5 years who developed RCC and his systemic and articular symptoms paralleled the course of RCC. The common pathophysiologic influence of the cytokine Interleukin-6 possibly played a role in the exacerbation of symptoms of systemic onset JIA during the relapse of the RCC. The case is presented to highlight the rare co-occurrence of these two diseases and their influence on each other.
authors.affiliation: Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Sarma
authors.forename: Amita
authors.initials: A
authors.lastname: Aggarwal
authors.forename: Ramnath
authors.initials: R
authors.lastname: Misra
authors.forename: Amit
authors.initials: A
authors.lastname: Chauhan
authors.forename: Vikas
authors.initials: V
authors.lastname: Agarwal
mesh_terms: D000293:Adolescent; D000974:Antibodies, Antinuclear / Q000032:analysis; D001171:Arthritis, Juvenile / Q000175:diagnosis / Q000209:etiology*; D001706:Biopsy; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000175:diagnosis; D008297:Male; D010257:Paraneoplastic Syndromes
chemical_list: D000974:Antibodies, Antinuclear