title: [Seasonal changes in the isoform composition of the myosin heavy chains in skeletal muscles of hibernating ground squirrels Spermophilus undulatus].
abstract: Seasonal changes of the isoform composition of myosin heavy chains in skeletal muscles (m. triceps, m. longissimus dorsi, m. soleus, m. gastrocnemius, m. vastus lateralis) of hibernating ground squirrels Spermophilus undulatus were studied. Functional properties of myosin (the actin-activated ATPase activity and its Ca(2+)-sensitivity in vitro) were also examined. It was observed that the content of slow myosin heavy chain I isoform increased and the content of fast IIx/d isoform decreased in muscles of torpid ground squirrels and animals which are active in autumn and winter. In muscles of these animals the content of N2A-titin isorfom decreased although the relative content of NT-titin isoform, observed in striated muscles of mammals in our previous experimental works, increased. Actin-activated ATPase activity and Ca(2+)-sensitivity of myosin isolated from skeletal muscles of torpid and interbout ground squirrels were found to reduce. The changes observed are discussed in the context of adaptation of skeletal muscles of ground squirrels to hibernation conditions.
authors.forename: M V
authors.initials: MV
authors.lastname: Lazareva
authors.forename: K O
authors.initials: KO
authors.lastname: Trapeznikova
authors.forename: I M
authors.initials: IM
authors.lastname: Vikhliantsev
authors.forename: A G
authors.initials: AG
authors.lastname: Bobylev
authors.forename: A A
authors.initials: AA
authors.lastname: Klimov
authors.forename: Z A
authors.initials: ZA
authors.lastname: Podlubnaia
mesh_terms: D000199:Actins / Q000737:chemistry; D000222:Adaptation, Physiological; D000818:Animals; D002118:Calcium / Q000737:chemistry; D006605:Hibernation / Q000502:physiology*; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism; D018995:Myosin Heavy Chains / Q000737:chemistry / Q000378:metabolism; D009218:Myosins / Q000737:chemistry / Q000378:metabolism; D020033:Protein Isoforms / Q000737:chemistry*; D012589:Sciuridae; D012621:Seasons
chemical_list: D000199:Actins; D020033:Protein Isoforms; D018995:Myosin Heavy Chains; D009218:Myosins; D002118:Calcium