title: [A comparative evaluation of the efficacy of valdoxan (agomelatine) in recurrent depression and bipolar affective disorder].
abstract: Authors compared the efficacy and safety of valdoxan in the treatment of depression in 22 patients with recurrent depressive disorder (RD) and 23 patients with bipolar affective disorder (BAD). Valdoxan was used on the night in dosage 25-50 mg during 8 weeks. Efficacy was assessed with psychometric scales HAM-D-17, CGI-S, CGI-I and visual analogous scales for falling asleep, night sleep quality, morning status and day activity. The antidepressant effect of the drug and the normalization of circadian rhythms were seen in the first week of treatment. To the end of treatment, there were 90.9% responders in the group with BAD and 91.3% in patients with RD. Percentages of patients with remission were 65.2% and 54.5%, respectively. It has been concluded that valdoxan does not cause unwanted side-effects as well as the risk of the inversion of a phase and/or the development of transitory hypomania in BAD.
authors.forename: N A
authors.initials: NA
authors.lastname: Tiuvina
authors.forename: V N
authors.initials: VN
authors.lastname: Smirnova
mesh_terms: D000081:Acetamides / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D002940:Circadian Rhythm / Q000187:drug effects; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D044122:Receptor, Melatonin, MT1 / Q000819:agonists*; D044123:Receptor, Melatonin, MT2 / Q000819:agonists*; D012008:Recurrence; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000928:Antidepressive Agents; D044122:Receptor, Melatonin, MT1; D044123:Receptor, Melatonin, MT2; D058830:Serotonin 5-HT2 Receptor Antagonists; C084711:agomelatine; D009281:Naphthalenes