title: Synthesis of new triazole acetamides with inotropic effects.
abstract: A series of new triazole acetamides 5a-w were synthesized and evaluated for their positive inotropic activity of left atrium stroke volume on isolated rabbit-heart preparations. The majority of the derivatives presented favorable in vitro activity compared with the reference drug, milrinone. Among them triazole acetamide 5a was identified as the most potent with 20.29 ± 0.18% increased stroke volume (milrinone: 2.46 ± 0.07%) at a concentration of 3 × 10(-5) M. The chronotropic effects of the compounds having inotropic effects were also evaluated.
authors.affiliation: Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, Yanji 133000, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Long-Xu
authors.initials: LX
authors.lastname: Ma
authors.forename: Liang-Peng
authors.initials: LP
authors.lastname: Sun
authors.forename: Ming-Xia
authors.initials: MX
authors.lastname: Song
authors.forename: Xun
authors.initials: X
authors.lastname: Cui
authors.forename: Hu-Ri
authors.initials: HR
authors.lastname: Piao
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D020105:Milrinone / Q000494:pharmacology; D011817:Rabbits; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000081:Acetamides; D002316:Cardiotonic Agents; D014230:Triazoles; D020105:Milrinone