title: [Connections between apolipoprotein E genotypes and the development of cardiovascular diseases].
abstract: Elevated plasma lipid level is one of the main risk factors for cardiovascular diseases, which are considered to be primary causes of death. Apolipoprotein E plays a part in the lipid transport in the blood, thus polimophisms of that affect the lipid composition of the plasma. The three most common alleles of apolipoprotein E are e2, e3, e4. Out of the two non-wild type alleles, the e2 and e4, the latter was shown to play a role in the development of cardiovascular diseases and Alzheimer's disease. Some studies mention the e2/e2 homozygote genotype as one of the causes of hyperlipoproteinemia type III. Besides lipid metabolism, apolipoprotein E also influences the manifestation of cardiovascular diseases through other biochemical pathways, therefore it is essential to explore the molecular background of these metabolic pathways.
authors.affiliation: Genetikával Az Egészségért Egyesület, Budapest.
authors.forename: Csaba
authors.initials: C
authors.lastname: Végh
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Langmár
authors.forename: Melinda
authors.initials: M
authors.lastname: Szerző
authors.forename: Annamária
authors.initials: A
authors.lastname: Agota
authors.forename: Krisztina
authors.initials: K
authors.lastname: Marosi
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szabolcs
authors.forename: Zsolt B
authors.initials: ZB
authors.lastname: Nagy
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D053329:Apolipoprotein E2 / Q000378:metabolism; D053318:Apolipoprotein E3 / Q000378:metabolism; D053327:Apolipoprotein E4 / Q000378:metabolism; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000097:blood; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006952:Hyperlipoproteinemia Type III / Q000150:complications / Q000235:genetics; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008078:Cholesterol, LDL