title: Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes.
abstract: Type 2 diabetes (T2DM) is a multi-factorial disease with a complex pathogenic mechanism; however a complete understanding of precise biochemical alterations accompanying the onset and progression of T2DM is lacking. Using a combination of untargeted and targeted metabolomic profiling approach we were able to delineate significantly altered metabolites in the diabetic (T2DM) group. Our results indicate significant perturbations in amino acid metabolism, TCA cycle and glycerol-phospholipid metabolism possibly impacting the overall glucose homeostasis in T2DM. A systems approach offers promise towards identification of clinically relevant markers of T2DM and novel molecular targets to foster drug discovery for effective therapeutic development for diabetes.
authors.affiliation: Department of Oncology, Lombardi Comprehensive Cancer Center at Georgetown University Medical Center, Washington, DC, USA.
authors.forename: Prabhjit
authors.initials: P
authors.lastname: Kaur
authors.forename: Nasser
authors.initials: N
authors.lastname: Rizk
authors.forename: Sereen
authors.initials: S
authors.lastname: Ibrahim
authors.forename: Yue
authors.initials: Y
authors.lastname: Luo
authors.forename: Noura
authors.initials: N
authors.lastname: Younes
authors.forename: Brian
authors.initials: B
authors.lastname: Perry
authors.forename: Kevin
authors.initials: K
authors.lastname: Dennis
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Zirie
authors.forename: George
authors.initials: G
authors.lastname: Luta
authors.forename: Amrita K
authors.initials: AK
authors.lastname: Cheema
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism / Q000652:urine; D016022:Case-Control Studies; D002952:Citric Acid Cycle; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism* / Q000652:urine; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008297:Male; D055442:Metabolome; D055432:Metabolomics; D008875:Middle Aged; D010743:Phospholipids / Q000378:metabolism*; D015203:Reproducibility of Results
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D010743:Phospholipids