title: Synthesis of 2-aryl-1,2-dihydrophthalazines via reaction of 2-(bromomethyl)benzaldehydes with arylhydrazines.
abstract: The reaction of 2-(bromomethyl)benzaldehydes with arylhydrazines employing K(2)CO(3) as a base and FeCl(3) as a catalyst in CH(3)CN at 100 °C delivers 2-aryl-1,2-dihydrophthalazines with yields ranging from 60 to 91%. The transformation is considered to proceed as an intermolecular condensation/intramolecular nucleophilic substitution.
authors.affiliation: Bioorganische Chemie, Institut für Chemie, Universität Hohenheim, Garbenstrasse 30, D-70599 Stuttgart, Germany.
authors.forename: Nayyef
authors.initials: N
authors.lastname: Aljaar
authors.forename: Jürgen
authors.initials: J
authors.lastname: Conrad
authors.forename: Uwe
authors.initials: U
authors.lastname: Beifuss
mesh_terms: D001547:Benzaldehydes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010793:Phthalazines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001547:Benzaldehydes; D010793:Phthalazines