title: Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions.
abstract: Development of specific ligands for protein targets that help decode the complexities of protein-protein interaction networks is a key goal for the field of chemical biology. Despite the emergence of powerful in silico and experimental high-throughput screening strategies, the discovery of synthetic ligands that selectively modulate protein-protein interactions remains a challenge for bioorganic and medicinal chemists. This Perspective discusses emerging principles for the rational design of PPI inhibitors. Fundamentally, the approach seeks to adapt nature's protein recognition principles for the design of suitable secondary structure mimetics.
authors.affiliation: Department of Chemistry, New York University, NY 10003, USA.
authors.forename: Monika
authors.initials: M
authors.lastname: Raj
authors.forename: Brooke N
authors.initials: BN
authors.lastname: Bullock
authors.forename: Paramjit S
authors.initials: PS
authors.lastname: Arora
mesh_terms: D003198:Computer Simulation; D016503:Drug Delivery Systems; D008958:Models, Molecular; D011485:Protein Binding / Q000187:drug effects; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology
chemical_list: D011506:Proteins; D054852:Small Molecule Libraries