title: When guests simply will not leave.
abstract: Chronic pathogens have evolved exquisite mechanisms of self-regulation via manipulation of host signaling pathways; however, pathologic consequences may ensue. Tsugawa et al. (2012) now report a mechanism of checks and balances used by Helicobacter pylori that is undermined by gastric stem cells, which may lower the threshold for gastric cancer.
authors.affiliation: Department of Medicine, Vanderbilt University, Nashville, TN 37232-2279, USA.
authors.forename: Lydia E
authors.initials: LE
authors.lastname: Wroblewski
authors.forename: Richard M
authors.initials: RM
authors.lastname: Peek
mesh_terms: D000942:Antigens, Bacterial / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D017382:Reactive Oxygen Species / Q000276:immunology*; D037521:Virulence Factors / Q000378:metabolism*; D014836:Volition
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D017382:Reactive Oxygen Species; D037521:Virulence Factors