title: Effect of guanidinylation on the properties of poly(2-aminoethylmethacrylate)-based antibacterial materials.
abstract: The effect of converting ammonium into guanidine moieties, compared to other factors such as molecular weight or hydrophobicity, on the antibacterial activity is investigated for homo- and copolymers of 2-aminoethylmethacrylate in solution or coatings. Polymers are obtained by free radical polymerization, polymer-analogous guanidinylation is conducted with cyanamide; non-leaching immobilization is achieved by LBL assembly of homopolymers or crosslinking of functional sidegroups in copolymers. Antibacterial activity to Escherichia coli or Bacillus subtilis is determined by different standard methods. Guanidinylation improves antibacterial activity and speed as well as cytotoxicity of hydrophilic homo- and copolymers in solution or coatings.
authors.affiliation: Philipps-Universität Marburg, Fachbereich Chemie, Marburg, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Mattheis
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Claus
authors.initials: C
authors.lastname: Meister
authors.forename: Seema
authors.initials: S
authors.lastname: Agarwal
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D019791:Guanidine / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008689:Methacrylates / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D058105:Polymerization; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D008689:Methacrylates; D011109:Polymethacrylic Acids; C072703:2-aminoethylmethacrylate; D019791:Guanidine