title: Siladenoserinols A-L: new sulfonated serinol derivatives from a tunicate as inhibitors of p53-Hdm2 interaction.
abstract: Siladenoserinols A-L were isolated from a tunicate as inhibitors of p53-Hdm2 interaction, a promising target for cancer chemotherapy. Their structures including the absolute configurations were elucidated to be new sulfonated serinol derivatives, each of which contains a 6,8-dioxabicyclo[3.2.1]octane unit and either glycerophosphocholine or glycerophosphoethanolamine moiety. They inhibited p53-Hdm2 interaction with IC(50) values of 2.0-55 μM. Among them, siladenoserinol A and B exhibited the strongest inhibition with an IC(50) value of 2.0 μM.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kato
authors.forename: Tadateru
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Iwasaki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Suwa
authors.forename: Henki
authors.initials: H
authors.lastname: Rotinsulu
authors.forename: Fije
authors.initials: F
authors.lastname: Losung
authors.forename: Wilmar
authors.initials: W
authors.lastname: Maarisit
authors.forename: Remy E P
authors.initials: RE
authors.lastname: Mangindaan
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morioka
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Yokosawa
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
mesh_terms: D000818:Animals; D006801:Humans; D015394:Molecular Structure; D011412:Propanolamines; D011409:Propylene Glycols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000037:antagonists & inhibitors / Q000187:drug effects* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors / Q000187:drug effects* / Q000378:metabolism; D014561:Urochordata / Q000737:chemistry*
chemical_list: D011412:Propanolamines; D011409:Propylene Glycols; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; C072422:serinol