title: Candidate gene marker associations with fatty acid profiles in heavy pigs.
abstract: Heavy pigs are used in Italy to produce fresh meat, dry-cured ham, salami and lard. Fatty acid profile determines both the dietary and organoleptic qualities of these products. The objective was to study the polymorphisms of two genes that code for enzymes of the fatty acid metabolism, namely, Stearoyl-CoA desaturase (SCD) and Fatty acid desaturase 2 (FADS2). We also investigated the polymorphism of the Sterol regulatory element binding protein gene (SREBF1) as it regulates SCD and FADS2 transcription. Significant associations of SCD were found with the ratio of oleic to stearic acid; with the concentration (g/100g of fat) of stearic and oleic acids. The concentrations of arachidonic and linoleic acids and the ratio of dihomo-gamma-linolenic to linoleic acid were significantly associated with FADS2 polymorphisms. SREBF1 polymorphism was associated with oleic acid concentrations and the ratio of arachidonic to linoleic acids. Our findings suggest that the SCD, FADS2 and SREBF1 polymorphisms are associated with dietary quality of heavy pig meat products.
authors.affiliation: Veterinary Physiology and Nutrition Lab, Department of Food Science, University of Udine, Italy. benedicte.renaville@uniud.it
authors.forename: B
authors.initials: B
authors.lastname: Renaville
authors.forename: A
authors.initials: A
authors.lastname: Prandi
authors.forename: B
authors.initials: B
authors.lastname: Fan
authors.forename: A
authors.initials: A
authors.lastname: Sepulcri
authors.forename: M F
authors.initials: MF
authors.lastname: Rothschild
authors.forename: E
authors.initials: E
authors.lastname: Piasentier
mesh_terms: D000818:Animals; D001835:Body Weight; D004041:Dietary Fats / Q000378:metabolism*; D044943:Fatty Acid Desaturases / Q000235:genetics*; D005227:Fatty Acids / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D008460:Meat / Q000032:analysis*; D011110:Polymorphism, Genetic; D013230:Stearoyl-CoA Desaturase / Q000235:genetics*; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics; D013552:Swine
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D051780:Sterol Regulatory Element Binding Protein 1; D044943:Fatty Acid Desaturases; D013230:Stearoyl-CoA Desaturase