title: The clinical outcomes of extracorporeal irradiated and re-implanted cemented autologous bone graft of femoral diaphysis after tumour resection.
abstract: OBJECTIVE
  We report the outcome of intercalary resection of the femoral diaphysis and extracorporeal irradiated autologous bone graft reconstruction, without the use of vascularized fibular graft.
  
  
  METHODS
  Six patients with Ewing sarcoma of the mid-shaft femur who were treated by limb sparing tumour resection and reconstruction with extracorporeal irradiated autologous bone graft with intramedullary cement between 2002 and 2010 were studied.
  
  
  RESULTS
  Mean age at the time of surgery was ten years (range, four-23). The length of resected femoral bone averaged 23 cm (15-32 cm). The ratio of bone resection length to total femoral length averaged 60 % (56-66 %). The patients had been followed up for between 16 and 79 months (mean, 41 months) at the time of the study. There was no infection nor fracture in this series. Primary union of the distal and proximal osteotomy sites was achieved in three patients. Delayed union of the proximal osteotomy site occurred in one patient that was successfully treated with iliac crest bone grafting. One patient developed non-union at the distal osteotomy site which failed to heal with bone grafting and was therefore converted to endoprosthetic replacement, and another patient was converted to rotationplasty at five months post-surgery because of contaminated margins. Function was excellent in all patients with surviving re-implanted bone. Local recurrence arose in one patient.
  
  
  CONCLUSIONS
  Our experience suggests that cement augmentation of extracorporeal irradiated and re-implanted bone autografts offer a useful method of reconstructing large femoral diaphyseal bone defects after excision of primary malignant bone tumours.
authors.affiliation: Oncology Service, The Royal Orthopaedic Hospital, Bristol Road South, Birmingham, B31 2AP, UK.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nakamura
authors.forename: Adesegun
authors.initials: A
authors.lastname: Abudu
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Grimer
authors.forename: Simon R
authors.initials: SR
authors.lastname: Carter
authors.forename: Lee
authors.initials: L
authors.lastname: Jeys
authors.forename: Roger M
authors.initials: RM
authors.lastname: Tillman
mesh_terms: D000293:Adolescent; D001843:Bone Cements; D001859:Bone Neoplasms / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D018483:Diaphyses / Q000000981:diagnostic imaging / Q000528:radiation effects / Q000637:transplantation; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000528:radiation effects* / Q000637:transplantation*; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D023821:Limb Salvage / Q000379:methods; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D010027:Osteotomy / Q000379:methods*; D011859:Radiography; D012512:Sarcoma, Ewing / Q000601:surgery*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001843:Bone Cements