title: Chemical and physical models for the emergence of biological homochirality.
abstract: The past several decades have witnessed the development of a number of different experimental approaches to help understand how the homochirality of biological molecules might have evolved in a prebiotic world. This chapter reviews chemical and physical models with a special focus on recent developments in attrition-enhanced deracemization of conglomerates, a process that combines solution phase chemical interconversion of enantiomers with thermodynamic and kinetic considerations of solubility, crystal growth, and dissolution.
authors.affiliation: Chemistry and Chemical Biology University of California Merced, Merced, CA, 95343, USA, jhein2@ucmerced.edu.
authors.forename: Jason E
authors.initials: JE
authors.lastname: Hein
authors.forename: Dragos
authors.initials: D
authors.lastname: Gherase
authors.forename: Donna G
authors.initials: DG
authors.lastname: Blackmond
mesh_terms: D055162:Biocatalysis; D003460:Crystallization; D007700:Kinetics; D008956:Models, Chemical; D012995:Solubility; D013237:Stereoisomerism