title: Chromatin organization: form to function.
abstract: Recent developments in technology have made it possible to create high resolution genome-wide maps of histone marks, DNA binding proteins and physical interactions along genomic regions. Chromatin features are found together in different combinations, dividing the genome up into domains with distinct functional properties. Microscopy and chromatin conformation capture techniques have shown that the 3D structure of chromosomes is constrained by nuclear features and functional links between different parts of chromatin. These results provide insights about the 3D and domain organization of the genome and their connection to gene regulation and other nuclear functions.
authors.affiliation: Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands.
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: de Graaf
authors.forename: Bas
authors.initials: B
authors.lastname: van Steensel
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics; D002843:Chromatin / Q000235:genetics / Q000648:ultrastructure*; D002875:Chromosomes / Q000235:genetics / Q000648:ultrastructure*; D004268:DNA-Binding Proteins / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D005786:Gene Expression Regulation; D016678:Genome; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D012441:Saccharomyces cerevisiae / Q000235:genetics
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D006657:Histones