title: Chest wall resection and reconstruction for locally advanced primary breast cancer.
abstract: OBJECTIVE
  We sought to evaluate clinical and oncologic outcomes of selected patients with locally advanced breast cancer undergoing full thickness chest wall resection (FTCWR) and reconstruction in a multidisciplinary setting.
  
  
  METHODS
  Between 2008 and 2010, five women underwent FTCWR followed by chest wall repair for locally advanced primary breast cancer. In all cases, chest wall repair was performed with a Peri-Guard Repair Patch (Synovis, St. Paul, MN, USA). At follow-up (7-12 months) quality of life, respiratory function and oncologic status were assessed.
  
  
  RESULTS
  Successful chest wall resection and repair were achieved in all patients. Plastic reconstruction of post-mastectomy tissue defects was necessary in one case. One patient was treated by breast conserving therapy. Chest ultrasound imaging confirmed absence of adhesions, haematoma or seroma and normal expansion and respiratory movement of the underlying lung in all patients. On follow-up all patients reported good quality of life.
  
  
  CONCLUSIONS
  Multidisciplinary surgical approaches to chest wall resection and reconstruction in selected patients with locally advanced primary breast cancer are feasible, safe, associated with short operation time and hospital stay and negligible morbidity.
authors.affiliation: Department of Obstetrics and Gynaecology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Ursula.hille@mh-hannover.de
authors.forename: Ursula
authors.initials: U
authors.lastname: Hille
authors.forename: Philipp
authors.initials: P
authors.lastname: Soergel
authors.forename: Patrick
authors.initials: P
authors.lastname: Zardo
authors.forename: Stefanie
authors.initials: S
authors.lastname: Pertschy
authors.forename: Kai
authors.initials: K
authors.lastname: Busch
authors.forename: Stefan
authors.initials: S
authors.lastname: Fischer
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D044584:Carcinoma, Ductal / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy; D007902:Length of Stay; D008408:Mastectomy; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D019651:Plastic Surgery Procedures / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D035441:Thoracic Wall / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome