title: Targeting c-FLICE-like inhibitory protein (CFLAR) in cancer.
abstract: BACKGROUND
  Evasion of apoptosis (programmed cell death) is one of the characteristic hallmarks of human cancers and may be caused by aberrant expression of antiapoptotic proteins. Among those is c-FLICE-like inhibitory protein (c-FLIP), a protein that not only blocks apoptosis signaling but also regulates additional cell death pathways.
  
  
  METHODS
  Because c-FLIP is regulated both at the transcriptional and posttranscriptional level by various mechanisms and is a short-lived protein with a rapid turnover, the regulation of c-FLIP expression represents a versatile tool to modulate cell death signaling pathways. Because c-FLIP is aberrantly expressed in various cancers, it represents a promising target for therapeutic intervention.
  
  
  CONCLUSIONS
  Therefore, insights into the molecular events that regulate c-FLIP expression and activity in human cancers will provide the basis for the development of new strategies to target c-FLIP expression in human cancers.
authors.affiliation: Goethe-University Frankfurt, Institute for Experimental Cancer Research in Pediatrics, Komturstr. 3a, 60528 Frankfurt, Germany. simone.fulda@kgu.de
authors.forename: Simone
authors.initials: S
authors.lastname: Fulda
mesh_terms: D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000378:metabolism*; D016923:Cell Death; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D053446:CASP8 and FADD-Like Apoptosis Regulating Protein