title: [Dermohypodermitis and gut translocation Escherichia coli septicemia in a newborn infant].
abstract: The burden of neonatal bacterial infections continues. They remain a significant cause of death and morbidity, despite recommendations for prevention. The epidemiology of these infections has changed. Currently the two most causative pathogens for early-onset neonatal sepsis and for late-onset sepsis in term infants are Group B streptococci (GBS) and Escherichia coli. E. coli's role is increasingly important since the widespread use of intrapartum antibiotic prophylaxis. In late-onset infections, one of the suggested pathophysiological mechanisms is microbial translocation in the gut secondary to digestive colonization, particularly when E. coli is isolated in blood cultures. This can occur either before or after birth. Bacterial sepsis can be associated with various non-specific peripheral manifestations involving skin and soft tissues. We report the case of a full-term, 26-day-old newborn admitted to the hospital for fever. She presented with dermohypodermitis of the left trunk and was diagnosed with E. coli septicemia. She was discharged in good condition after appropriate intravenous antibiotic therapy.
authors.affiliation: Service de pédiatrie et néonatologie, centre hospitalier Jacques-Cœur, Bourges cedex, France. elodie_gouache@yahoo.fr
authors.forename: E
authors.initials: E
authors.lastname: Gouache
authors.forename: E
authors.initials: E
authors.lastname: Chantier
authors.forename: N
authors.initials: N
authors.lastname: Hubert
authors.forename: M-F
authors.initials: MF
authors.lastname: Rivière
mesh_terms: D000005:Abdomen / Q000473:pathology; D000583:Amikacin / Q000627:therapeutic use; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D018988:Bacterial Translocation; D002439:Cefotaxime / Q000627:therapeutic use; D004926:Escherichia coli / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005243:Feces / Q000382:microbiology; D005260:Female; D005334:Fever / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D012871:Skin Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D013909:Thorax / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D000583:Amikacin; D002439:Cefotaxime