title: Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives.
abstract: Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC(50) < 10 μg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25-32 μg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.
authors.affiliation: Laboratorio de Química Orgánica y Biomolecular, Escuela de Química, Universidad Industrial de Santander, A. A. 678, Bucaramanga, Colombia.
authors.forename: Vladímir V
authors.initials: VV
authors.lastname: Kouznetsov
authors.forename: Susana A
authors.initials: SA
authors.lastname: Zacchino
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Sortino
authors.forename: Leonor Y
authors.initials: LY
authors.lastname: Vargas Méndez
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Gupta