title: Comparison the effects of oxytocin and methylergonovine in elective caesarean section under spinal anesthesia.
abstract: OBJECTIVE
  In order to prevent postpartum hemorrhage in caesarean section under spinal anesthesia, patients routinely receive oxytocin. In this study we compared the efficacy of Methylergonovine and Oxytocin on hemodynamic stability and bleeding amount in caesarean section.
  
  
  METHODS
  In this randomised controlled trial study, 80 patients candidate for elective caesarean section under spinal anesthesia divided to two groups: 40 patients in control group received oxytocin and 40 ones in case group received methylergonovine.
  
  
  RESULTS
  There was no differences between groups in Mean age, baseline hemodynamic values, after spinal anesthesia and recovery (except diastolic blood pressure min 20), time of uterine atony, dizziness; nausea and vomiting. After drug administration (oxytocin and methylergonovine), systolic blood pressure in minutes 1, 10, 15 and diastolic blood pressure in minutes 1, 3, 20 increased in case group statistically more than control group. In control group, heart rate in minutes 1, 5 increased significantly more than the other group. Mean arterial blood pressure in minutes 1, 3, 5, 10, 15 reduced significantly more than in control group. Need to vasoconstrictor drug statistically was less in case group (p < 0.0001).
  
  
  CONCLUSIONS
  Methylergonovine induced significantly more hemodynamic stability. Adverse effects were similar between two groups. We recommend the use of methylergonovine in patients with caesarean section under spinal anesthesia because of its hemodynamic stability and low need to vasoconstrictor drugs.
authors.affiliation: Anesthesiology Department, University of Medical Sciences, Bushehr, Iran.
authors.forename: Abdorasoul
authors.initials: A
authors.lastname: Anvaripour
authors.forename: Houshang
authors.initials: H
authors.lastname: Shahryari
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Ahmadi
authors.forename: Soghra
authors.initials: S
authors.lastname: Ghasemi
authors.forename: Kamran
authors.initials: K
authors.lastname: Mirzaei
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D001794:Blood Pressure / Q000187:drug effects; D002585:Cesarean Section / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008755:Methylergonovine / Q000008:administration & dosage* / Q000009:adverse effects; D010120:Oxytocics / Q000008:administration & dosage*; D010121:Oxytocin / Q000008:administration & dosage* / Q000009:adverse effects; D006473:Postpartum Hemorrhage / Q000209:etiology / Q000517:prevention & control; D011247:Pregnancy; D011446:Prospective Studies; D016037:Single-Blind Method
chemical_list: D010120:Oxytocics; D010121:Oxytocin; D008755:Methylergonovine