title: Is the MDR1 C3435T polymorphism responsible for oral mucositis in children with acute lymphoblastic leukemia?
abstract: OBJECTIVE
  Although the functional consequences of MDR-1 polymorphisms have been the subject of numerous studies, to the best to our knowledge, associations with clinical side effects of anticancer drugs have yet to be assessed. Our aim was to clarify any role of the C3435T polymorphism of the MDR1 gene in oral mucositis and its relation with elevated reactive oxygen species (ROS) levels, in children with acute lymphoblastic leukemia (ALL).
  
  
  METHODS
  The distribution of the MDR-1 C3435T polymorphism in 47 patients with ALL was determined by RFLP and compared with that of 68 healthy controls.
  
  
  RESULTS
  There were no association in distribution of genotypes of MDR-1 C3435T polymorphism and the risk of ALL. Oral mucositis were detected in 78.7% (n=37) of the patients and significantly related to the MDR-1 CT genotype (p=0.042), as confirmed by logistic regression analysis.
  
  
  CONCLUSIONS
  Our preliminary data suggest that children carrying the CT genotype are more prone to develop oral mucositis, which might mean that the heterozygous genotype leads to accumulation of more reactive oxygen species. Since a limited number of patients was investigated, further studies are needed to confirm these findings.
authors.affiliation: Department of Oral Surgery and Medicine, Faculty of Dentistry, Istanbul University, Istanbul, Turkey. bektaskk@istanbul.edu.tr
authors.forename: Kivanç
authors.initials: K
authors.lastname: Bektaş-Kayhan
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Küçükhüseyin
authors.forename: Gizem
authors.initials: G
authors.lastname: Karagöz
authors.forename: Meral
authors.initials: M
authors.lastname: Ünür
authors.forename: Oğuz
authors.initials: O
authors.lastname: Öztürk
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Ünüvar
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Devecioğlu
authors.forename: Hülya
authors.initials: H
authors.lastname: Yilmaz-Aydoğan
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000235:genetics; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000378:metabolism; D012307:Risk Factors; D013280:Stomatitis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D017382:Reactive Oxygen Species