title: Laparoscopy-assisted versus open surgery for gastrointestinal stromal tumors of jejunum and ileum: perioperative outcomes and long-term follow-up experience.
abstract: Whether laparoscopy-assisted resections for gastrointestinal stromal tumors (GISTs) of small bowel can achieve more benefits on the aspect of postoperative outcomes than open surgery remains a question. The aim of this study is to evaluate the benefits of laparoscopy-assisted surgery  for GISTs of jejunum and ileum on the perioperative outcomes and long-term relapse-free survival. From January 2004 to December 2010, 81 patients who underwent either laparoscopy-assisted (LAP group, n = 43) or open surgery (OPEN group, n = 38) were included in final analysis after the eligibility  criteria. Clinicopathological characteristics of the selected patients were similar between the two groups. Oral intake was significant earlier (P < 0.001) and postoperative hospital stay duration was significantly shorter (P < 0.001) in the LAP group than in the OPEN group.  The complication rate of patients in the LAP group and OPEN group was 9.3 and 26.3 per cent, respectively (P = 0.04). No significant difference was observed in terms of 5-year relapse-free survival between LAP and OPEN groups (91.1 vs 93.8%, P = 0.4). Laparoscopy-assisted  surgery for GISTs of jejunum and ileum could get preferable short-term postoperative outcomes and similar long-term relapse-free survival compared with open surgery, so it should be recommended for GISTs of the small intestine.
authors.affiliation: Department of Surgery, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wan
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Yan
authors.forename: Chao
authors.initials: C
authors.lastname: Yan
authors.forename: Zheng Gang
authors.initials: ZG
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002681:China; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D046152:Gastrointestinal Stromal Tumors / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007082:Ileum / Q000473:pathology / Q000601:surgery; D007583:Jejunum / Q000473:pathology / Q000601:surgery; D053208:Kaplan-Meier Estimate; D010535:Laparoscopy / Q000379:methods* / Q000401:mortality; D007813:Laparotomy / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult