title: Lessons from the REACH Registry in Europe.
abstract: Among patients with atherothrombosis, including coronary artery disease (CAD), cerebrovascular disease (CVD), and peripheral arterial disease (PAD), patients with PAD generally have the worse prognosis. The Reduction of Atherothrombosis for Continued Health (REACH) Registry characterized the atherothrombotic risk factor profile, and evaluated treatment intensity and cardiovascular events among different atherothrombotic patient populations worldwide. Two thirds of PAD patients had polyvascular disease, defined as symptomatic involvement of more than one vascular bed. The risk factor profile in patients with CAD, CVD and PAD was very much similar. However, optimal risk factor control by medical treatment and lifestyle interventions was least accomplished in PAD patients. Furthermore, PAD patients and patients with polyvascular disease showed the highest cardiovascular event rates. Of note, therapeutic strategies are similar for all atherothrombotic disease categories, irrespective of the presence of polyvascular disease. Therefore, it is of the utmost importance to achieve optimal risk factor control, particularly for PAD patients and for those with polyvascular disease, in order to prevent future cardiovascular events.
authors.affiliation: Department of Anesthesiology, Erasmus University Medical Center, Room H-1273, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
authors.forename: Tabita M
authors.initials: TM
authors.lastname: Valentijn
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Stolker
mesh_terms: D000368:Aged; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000401:mortality / Q000628:therapy*; D003324:Coronary Artery Disease / Q000401:mortality / Q000628:therapy*; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D058729:Peripheral Arterial Disease / Q000401:mortality / Q000628:therapy*; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D040242:Risk Reduction Behavior
chemical_list: D002317:Cardiovascular Agents