title: Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells.
abstract: Vialinin A is an extremely potent inhibitor of tumor necrosis factor (TNF)-α release from RBL-2H3 cells. The present study investigated in detail the inhibitory effects of vialinin A and its analog, 5',6'-dimethyl-1,1':4',1″-terphenyl-2',3',4,4″-tetraol (DMT), on TNF-α. Vialinin A and DMT inhibited the release of TNF-α from RBL-2H3 cells in a dose-dependent manner, but had no effect on β-hexosaminidase activity. Also, vialinins had little effect on TNF-α mRNA levels. Intriguingly, vialinins inhibited TNF-α production at low concentrations, but not shown a dose-dependency. The potent inhibitory activities of vialinins against TNF-α production and release suggest promising new candidate pathways for anti-inflammatory agents.
authors.affiliation: Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan. j1onose@nodai.ac.jp
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Onose
authors.forename: Yasukiyo
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: Yue Qi
authors.initials: YQ
authors.lastname: Ye
authors.forename: Kouichi
authors.initials: K
authors.lastname: Sugaya
authors.forename: Arata
authors.initials: A
authors.lastname: Yajima
authors.forename: Kayoko
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Okada
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yajima
authors.forename: Shunya
authors.initials: S
authors.lastname: Takahashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koshino
authors.forename: Naoki
authors.initials: N
authors.lastname: Abe
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D015550:Cell Degranulation / Q000187:drug effects*; D045744:Cell Line, Tumor; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D013730:Terphenyl Compounds / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism*; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D012333:RNA, Messenger; D013730:Terphenyl Compounds; D014409:Tumor Necrosis Factor-alpha; C508745:vialinin A; D001619:beta-N-Acetylhexosaminidases