title: [Impact of replacement therapy for subclinical hypothyroidism on cardiovascular risk markers in patients with type 2 diabetes mellitus].
abstract: OBJECTIVE
  To study the time course changes in the parameters of endothelial dysfunction in patients with type 2 diabetes mellitus (DM) and subclinical hypothyroidism (SH) in the natural course of SH and during replacement therapy.
  
  
  METHODS
  All the examined patients were divided into 2 groups: 1) 67 patients received replacement therapy with euthyrox in a dose of 25 to 100 microg/day; 2) 60 patients were followed up.
  
  
  RESULTS
  At the moment of study inclusion, there was a close direct correlation between the levels of cholesterol and the aggregate intima-media thickness (IMT) (r = 0.7) and between IMT and the levels of sICAM-1 (r = 0.71) and sVCAM-1 (r = 0.8). In the dynamics of the disease (following a year), the above correlations became weaker due to the performed treatment. A weak positive correlation was found between the aggregate IMT and the levels of sICAM-1 (r = 0.2) and sVCAM-1 (r = 0.3).
  
  
  CONCLUSIONS
  In patients with type 2 DM, the presence of SH serves as an additional risk factor for endothelial dysfunction. Replacement therapy will be able to considerably retard the progression of the disease and to reduce the incidence of vascular events.
authors.forename: S G
authors.initials: SG
authors.lastname: Kasatkina
authors.forename: T N
authors.initials: TN
authors.lastname: Panova
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control; D059168:Carotid Intima-Media Thickness; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy*; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
chemical_list: D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D002784:Cholesterol; D013974:Thyroxine