title: [A 5-year survival case of locally advanced cancer of the pancreatic body treated by distal pancreatectomy with en bloc celiac axis resection after neoadjuvant chemoradiation therapy].
abstract: A 59-year-old man was diagnosed with locally advanced cancer of the pancreatic body, involving the nerve plexus around the celiac axis, the common hepatic artery, and the splenic artery. He was treated with a combination of irradiation (2 Gy/day, total 24 Gy) and 600 mg/m2 of gemcitabine(GEM)biweekly. The tumor size and the involved plexus area were not diminished, but CA19-9 was reduced by half. Distal pancreatectomy with en bloc celiac axis resection(DP-CAR)was performed. The histological findings indicated extensive invasion into the nerve plexus, including that adjacent to the stump of the pancreas, and thus the R classification was R1. After surgery, 1,000 mg/m2 of GEM was administered biweekly. The chemotherapy has been performed for 5 years to prevent local and systemic recurrence. No recurrence has been found 5 years after surgery. Multidisciplinary treatment, combined with neoadjuvant chemoradiation therapy, curative-intent resection, and postoperative chemotherapy is important for effective treatment of locally advanced pancreatic cancer.
authors.affiliation: Dept. of Surgery, Tohoku University Graduate School of Medicine, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iseki
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Motoi
authors.forename: Masamichi
authors.initials: M
authors.lastname: Mizuma
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Kei
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Takaho
authors.initials: T
authors.lastname: Okada
authors.forename: Hideo
authors.initials: H
authors.lastname: Otsuka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ottomo
authors.forename: Naoaki
authors.initials: N
authors.lastname: Sakata
authors.forename: Koji
authors.initials: K
authors.lastname: Fukase
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Tohru
authors.initials: T
authors.lastname: Onogawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Naito
authors.forename: Yu
authors.initials: Y
authors.lastname: Katayose
authors.forename: Shinichi
authors.initials: S
authors.lastname: Egawa
authors.forename: Michiaki
authors.initials: M
authors.lastname: Unno
mesh_terms: D059248:Chemoradiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000628:therapy*; D013997:Time Factors