title: [Lung-brain interaction in the mechanically ventilated patient].
abstract: Patients with acute lung injury or acute respiratory distress syndrome (ARDS) admitted to the ICU present neuropsychological alterations, which in most cases extend beyond the acute phase and have an important adverse effect upon quality of life. The aim of this review is to deepen in the analysis of the complex interaction between lung and brain in critically ill patients subjected to mechanical ventilation. This update first describes the neuropsychological alterations occurring both during the acute phase of ICU stay and at discharge, followed by an analysis of lung-brain interactions during mechanical ventilation, and finally explores the etiology and mechanisms leading to the neurological disorders observed in these patients. The management of critical patients requires an integral approach focused on minimizing the deleterious effects over the short, middle or long term.
authors.affiliation: Fundació Parc Taulí, Corporació Sanitària Parc Taulí, Sabadell, Barcelona, España; Institut Universitari Parc Taulí, Universitat Autònoma de Barcelona, Campus d' Excelència Internacional, Bellaterra, Barcelona, España; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, España; Servicio de Medicina Intensiva, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Sabadell, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: López-Aguilar
authors.forename: M S
authors.initials: MS
authors.lastname: Fernández-Gonzalo
authors.forename: M
authors.initials: M
authors.lastname: Turon
authors.forename: M E
authors.initials: ME
authors.lastname: Quílez
authors.forename: V
authors.initials: V
authors.lastname: Gómez-Simón
authors.forename: M M
authors.initials: MM
authors.lastname: Jódar
authors.forename: L
authors.initials: L
authors.lastname: Blanch
mesh_terms: D000208:Acute Disease; D055371:Acute Lung Injury / Q000523:psychology / Q000628:therapy; D001288:Attention; D001812:Blood-Brain Barrier; D001921:Brain / Q000503:physiopathology*; D001925:Brain Damage, Chronic / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D002395:Catecholamines / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D003221:Confusion / Q000209:etiology* / Q000503:physiopathology; D016638:Critical Illness / Q000523:psychology; D016207:Cytokines / Q000502:physiology; D003693:Delirium / Q000209:etiology* / Q000503:physiopathology; D056344:Executive Function; D006801:Humans; D002534:Hypoxia, Brain / Q000209:etiology / Q000523:psychology / Q000628:therapy; D007362:Intensive Care Units; D008168:Lung / Q000503:physiopathology*; D009479:Neuropeptides / Q000502:physiology; D009483:Neuropsychological Tests; D012121:Respiration, Artificial / Q000009:adverse effects; D012128:Respiratory Distress Syndrome / Q000523:psychology / Q000628:therapy
chemical_list: D002395:Catecholamines; D016207:Cytokines; D009479:Neuropeptides