title: [A resected case of signet-ring cell carcinoma of the rectum].
abstract: Here, we present the case of a 76-year-old woman who consulted us in April 2010, following a positive fecal occult blood test, and was diagnosed with lower rectal cancer. Signet-ring cell carcinoma was diagnosed by histology. Because hydronephrosis of both sides was considered the cause of dissemination of the tumor, only chemotherapy was performed. After the eighth course of XELOX+bevacizumab treatment, hydronephrosis of both sides improved and the tumor marker level became normal. An abdominoperineal rectal resection was performed in February 2011. The results of pathological examination of the resected specimen showed complete response. After the operation, the tumor marker level was elevated, and recurrence in the pelvic cavity and multiple bone metastases were detected by positron emission tomography/ computed tomography. Chemotherapy has now been resumed. Signet-ring cell carcinoma is rare in colorectal cancer. The frequency of multiple organ metastases is high, and the growth rate of the tumor is also high. Poor prognosis compared to the usual colorectal cancer has been reported.
authors.affiliation: Dept. of Surgery, Hyogo Prefectural Nishinomiya Hospital, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Asukai
authors.forename: Shinichi
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Tomoki
authors.initials: T
authors.lastname: Hata
authors.forename: Sachiko
authors.initials: S
authors.lastname: Mizumoto
authors.forename: Kouzou
authors.initials: K
authors.lastname: Noguchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takiuchi
authors.forename: Rie
authors.initials: R
authors.lastname: Hamano
authors.forename: Masaki
authors.initials: M
authors.lastname: Kashiwazaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Miki
authors.forename: Masaki
authors.initials: M
authors.lastname: Tsujie
authors.forename: Muneharu
authors.initials: M
authors.lastname: Konishi
authors.forename: Kouji
authors.initials: K
authors.lastname: Yano
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D010386:Pelvic Neoplasms / Q000188:drug therapy* / Q000556:secondary; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012008:Recurrence