title: Antinociceptive Effect of Cyperi rhizoma and Corydalis tuber Extracts on Neuropathic Pain in Rats.
abstract: In this study, we examined the antinociceptive effect of Cyperi rhizoma (CR) and Corydalis tuber (CT) extracts using a chronic constriction injury-induced neuropathic pain rat model. After the ligation of sciatic nerve, neuropathic pain behavior such as mechanical allodynia and thermal hyperalgesia were rapidly induced and maintained for 1 month. Repeated treatment of CR or CT (per oral, 10 or 30 mg/kg, twice a day) was performed either in induction (day 0~5) or maintenance (day 14~19) period of neuropathic pain state. Treatment of CR or CT at doses of 30 mg/kg in the induction and maintenance periods significantly decreased the nerve injury-induced mechanical allodynia. In addition, CR and CT at doses of 10 or 30 mg/kg alleviated thermal heat hyperalgesia when they were treated in the maintenance period. Finally, CR or CT (30 mg/kg) treated during the induction period remarkably reduced the nerve injury-induced phosphorylation of NMDA receptor NR1 subunit (pNR1) in the spinal dorsal horn. Results of this study suggest that extracts from CR and CT may be useful to alleviate neuropathic pain.
authors.affiliation: Department of Physiology and Brain Research Institute, Chungnam National University Medical School, Daejeon 301-747, Korea.
authors.forename: Jae-Gyun
authors.initials: JG
authors.lastname: Choi
authors.forename: Suk-Yun
authors.initials: SY
authors.lastname: Kang
authors.forename: Jae-Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Roh
authors.forename: Seo-Yeon
authors.initials: SY
authors.lastname: Yoon
authors.forename: Jin Bong
authors.initials: JB
authors.lastname: Park
authors.forename: Jang-Hern
authors.initials: JH
authors.lastname: Lee
authors.forename: Hyun-Woo
authors.initials: HW
authors.lastname: Kim