title: New spin on an old transition: epithelial parallels in neuronal adhesion control.
abstract: During histogenesis of the vertebrate central nervous system (CNS), neuronal progenitors must interact with germinal zone (GZ) niches, differentiate, and morphologically mature, and neurons must migrate to their final positions. The extrinsic cues that control neurogenesis, specify neurons, and guide their movement are relatively well understood. However, less is known about how neurons spatiotemporally modify cell-cell interactions and cell polarization to navigate through complex, distinct cellular environments during neuronal circuit formation. Here we examine the parallels between the mechanisms controlling epithelial morphogenesis and the cell adhesion events by which neural cells organize GZ niches and direct neuronal migration. We focus on the emerging relationship between neuronal adhesive interactions and conserved cell-polarity signaling cascades.
authors.affiliation: Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
authors.forename: Jakub K
authors.initials: JK
authors.lastname: Famulski
authors.forename: David J
authors.initials: DJ
authors.lastname: Solecki
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology; D002450:Cell Communication; D019070:Cell Lineage; D002465:Cell Movement; D016764:Cell Polarity; D054338:Cell Transdifferentiation; D060833:Cellular Microenvironment; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology*; D006801:Humans; D008959:Models, Neurological; D009024:Morphogenesis; D009419:Nerve Tissue Proteins / Q000502:physiology*; D046569:Neuroepithelial Cells / Q000166:cytology / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D015815:Cell Adhesion Molecules; D015816:Cell Adhesion Molecules, Neuronal; D009419:Nerve Tissue Proteins