title: Treatment of pyelonephritis caused by extended-spectrum β-lactamase-producing Enterobacteriaceae in children.
abstract: Fifty-four children were diagnosed as pyelonephritis caused by extended-spectrum β-lactamase-producing Enterobacteriaceae at the largest children's hospital in Japan. Although 32 (59%) patients were treated with antimicrobials that are ineffective against the organisms, 39 (72%) patients became afebrile ≤2 days and clinical outcome was excellent. Children with pyelonephritis caused by extended-spectrum β-lactamase-producing Enterobacteriaceae can be successfully treated with noncarbapenem antimicrobials.
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, St. Marianna University School of Medicine, Kanagawa, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Katsuta
authors.forename: Kensuke
authors.initials: K
authors.lastname: Shoji
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Akihiko
authors.initials: A
authors.lastname: Saitoh
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D011704:Pyelonephritis / Q000188:drug therapy* / Q000382:microbiology*; D016896:Treatment Outcome; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases