title: Pharmacogenetics in primary care: the promise of personalized medicine and the reality of racial profiling.
abstract: Many anticipate that expanding knowledge of genetic variations associated with disease risk and medication response will revolutionize clinical medicine, making possible genetically based Personalized Medicine where health care can be tailored to individuals, based on their genome scans. Pharmacogenetics has received especially strong interest, with many pharmaceutical developers avidly working to identify genetic variations associated with individual differences in drug response. While clinical applications of emerging genetic knowledge are becoming increasingly available, genetic tests for drug selection are not as yet widely accessible, and many primary care clinicians are unprepared to interpret genetic information. We conducted interviews with 58 primary care clinicians, exploring how they integrate emerging pharmacogenetic concepts into their practices. We found that in their current practices, pharmacogenetic innovations have not led to individually tailored treatment, but instead have encouraged use of essentialized racial/ethnic identity as a proxy for genetic heritage. Current manifestations of Personalized Medicine appear to be reinforcing entrenched notions of inherent biological differences between racial groups, and promoting the belief that racial profiling in health care is supported by cutting-edge scientific authority. Our findings raise concern for how pharmacogenetic innovations will actually affect diverse populations, and how unbiased treatment can be assured.
authors.affiliation: Department of Anthropology, Michigan State University, 338 Baker Hall, East Lansing, MI 48824, USA. huntli@msu.edu
authors.forename: Linda M
authors.initials: LM
authors.lastname: Hunt
authors.forename: Meta J
authors.initials: MJ
authors.lastname: Kreiner
mesh_terms: D000328:Adult; D000368:Aged; D004198:Disease Susceptibility; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005820:Genetic Testing / Q000191:economics / Q000941:ethics*; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008824:Michigan; D008875:Middle Aged; D010597:Pharmacogenetics / Q000941:ethics*; D010818:Practice Patterns, Physicians'; D057285:Precision Medicine / Q000941:ethics* / Q000379:methods; D011320:Primary Health Care / Q000379:methods*; D044469:Racial Groups / Q000235:genetics*