title: Platelet volume indices have low diagnostic efficiency for predicting bone marrow failure in thrombocytopenic patients.
abstract: The aim of the present study was to evaluate the predictive efficiency of mean platelet volume (MPV) and platelet size deviation width (PDW) for bone marrow failure (BMF) in thrombocytopenic patients. Platelet count, MPV and PDW data were retrieved from the records of 574 unselected thrombocytopenic patients from between March 2010 and March 2011, of which 182 patients with a platelet count <20×10(9)/l were excluded from further study. A total of 392 valid thrombocytopenic patients were included in the present study and divided into two groups: 124 patients with idiopathic thrombocytopenia purpura (ITP) and 268 with BMF. The predictive efficiency of MPV and PDW were tested for the diagnosis of BMF. Significant differences were observed in the age distribution, platelet count, MPV and PDW between the ITP and BMF groups. The platelet count was positively correlated with MPV and PDW in the patients with ITP but not BMF. The negative-predictive values of MPV and PDW for BMF were 59.3 and 58.9%, respectively, with an MPV threshold of ≥11.0 fl and a PDW threshold of <16.0%. The positive-predictive values of MPV and PDW for BMF were 88.4 and 83.9%, respectively, with an MPV threshold <8.0 fl and a PDW threshold ≥17.5%. The areas under the curves (AUCs) of MPV and PDW were 0.281 and 0.700, respectively, for the diagnosis of BMF. The negative and positive-predictive values of MPV for BMF at different thresholds were not as conclusive as described in previous studies. MPV and PDW do not have sufficient specificity and sensitivity for the diagnosis of BMF in thrombocytopenic patients.
authors.affiliation: Department of Laboratory Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang 321000; ; School of Laboratory Medicine, Wenzhou Medical College, Wenzhou, Zhejiang 325027,  P.R. China.
authors.forename: Rui-Long
authors.initials: RL
authors.lastname: Xu
authors.forename: Zhao-Jing
authors.initials: ZJ
authors.lastname: Zheng
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Ma
authors.forename: Ying-Ping
authors.initials: YP
authors.lastname: Hu
authors.forename: Shun-Hong
authors.initials: SH
authors.lastname: Zhuang