title: The therapeutic potential of human umbilical cord blood transplantation for neonatal hypoxic-ischemic brain injury and ischemic stroke.
abstract: Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angiogenesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.
authors.affiliation: Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama 700-8558, Japan. f-wang@kochi-u.ac.jp
authors.forename: Feifei
authors.initials: F
authors.lastname: Wang
authors.forename: Nagamasa
authors.initials: N
authors.lastname: Maeda
authors.forename: Takao
authors.initials: T
authors.lastname: Yasuhara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kameda
authors.forename: Emi
authors.initials: E
authors.lastname: Tsuru
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Yamashita
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shen
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tsuda
authors.forename: Isao
authors.initials: I
authors.lastname: Date
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sagara
mesh_terms: D000818:Animals; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D004195:Disease Models, Animal; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000601:surgery*; D007231:Infant, Newborn; D020521:Stroke / Q000601:surgery*