title: Increased ubiquinone concentration after intracerebroventricularly-administered ubiquinol to selected rat brain regions.
abstract: Brain coenzyme Q10 (CoQ10) concentration can influence the activity of several brain regions, including those which participate in the regulation of cardiovascular circadian rhythms, food intake, neuroendocrine stress response, activity and sleep regulation. However, the effect of supplemented ubiquinol (reduced CoQ) into brain regions is not known. This study determined baseline levels of ubiquinone (oxidized CoQ) in various rat brain regions and proved the bioavailability of the liposomal ubiquinol to selected brain regions after its administration into right brain ventricle. Our data indicate that administration of ubiquinol  may create the basis for modulation of neuronal activities in specific brain regions.
authors.affiliation: Pharmacobiochemical Laboratory of 3rd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic. anna.gvozdjakova@fmed.uniba.sk
authors.forename: Anna
authors.initials: A
authors.lastname: Gvozdjáková
authors.forename: Boris
authors.initials: B
authors.lastname: Mravec
authors.forename: Jarmila
authors.initials: J
authors.lastname: Kucharská
authors.forename: Lubica
authors.initials: L
authors.lastname: Lackovičová
authors.forename: Katarína
authors.initials: K
authors.lastname: Ondičová
authors.forename: Martin
authors.initials: M
authors.lastname: Tkačov
authors.forename: Ram B
authors.initials: RB
authors.lastname: Singh
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D057967:Infusions, Intraventricular; D051381:Rats; D014018:Tissue Distribution; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D014451:Ubiquinone; C003741:ubiquinol