title: No support for a role for BDNF gene polymorphisms rs11030101 and rs61888800 in major depressive disorder or antidepressant response in patients of Finnish origin.
abstract: Brain-derived neurotrophic factor (BDNF) is suggested to play a role in the aetiology of major depression and in the antidepressant response in patients with major depression. Several BDNF gene polymorphisms have been investigated in the above-mentioned context. The aim of the present study was to examine the role of two BDNF gene polymorphisms (rs11030101 and rs61888800) in relation to the response to selective serotonin reuptake inhibitor medication in 106 patients of Finnish origin suffering from major depression. The secondary objective was to evaluate the association of these two BDNF polymorphisms in major depression, as we also had a control population of 386 healthy individuals. We did not find any significant differences in the distribution of these two BDNF gene polymorphisms in our patient population in relation to remission or response to treatment with selective serotonin reuptake inhibitor. Also, there were no significant differences between the patients and the controls.
authors.affiliation: Medical School, University of Tampere, Tampere, Finland.
authors.forename: Ari
authors.initials: A
authors.lastname: Illi
authors.forename: Merja
authors.initials: M
authors.lastname: Viikki
authors.forename: Outi
authors.initials: O
authors.lastname: Poutanen
authors.forename: Eija
authors.initials: E
authors.lastname: Setälä-Soikkeli
authors.forename: Timo
authors.initials: T
authors.lastname: Nuolivirta
authors.forename: Olli
authors.initials: O
authors.lastname: Kampman
authors.forename: Esa
authors.initials: E
authors.lastname: Leinonen
authors.forename: Heini
authors.initials: H
authors.lastname: Huhtala
authors.forename: Nina
authors.initials: N
authors.lastname: Mononen
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D003710:Demography; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human