title: Parathyroid hemorrhage occurring after administration of cinacalcet in a patient with secondary hyperparathyroidism.
abstract: We herein report an unusual case of spontaneous parathyroid gland rupture. A man was admitted with respiratory distress in September 2010. He had been receiving hemodialysis since 1995. He was diagnosed secondary hyperparathyroidism in 2006 and began receiving cinacalcet therapy in 2009. His intact parathyroid hormone (iPTH) level decreased, and massive traumatic bleeding occurred, following which rupture of the parathyroid gland was detected during surgery. The ruptured gland showed nodular hyperplasia. Previous reports have indicated that parathyroid bleeding is associated with glandular hypertrophy. This is the first report of parathyroid apoplexy occurring after suppression of elevated parathyroid function caused by cinacalcet therapy.
authors.affiliation: Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Japan.
authors.forename: Motonori
authors.initials: M
authors.lastname: Nagasawa
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ubara
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suwabe
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamanouchi
authors.forename: Noriko
authors.initials: N
authors.lastname: Hayami
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sumida
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Hattori
authors.forename: Maki
authors.initials: M
authors.lastname: Tsukamoto
authors.forename: Eriko
authors.initials: E
authors.lastname: Hiramatsu
authors.forename: Eiko
authors.initials: E
authors.lastname: Hasegawa
authors.forename: Junichi
authors.initials: J
authors.lastname: Hoshino
authors.forename: Naoki
authors.initials: N
authors.lastname: Sawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Marui
authors.forename: Michio
authors.initials: M
authors.lastname: Nakamura
authors.forename: Shinji
authors.initials: S
authors.lastname: Tomikawa
authors.forename: Kennmei
authors.initials: K
authors.lastname: Takaichi
mesh_terms: D000069449:Cinacalcet; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000009:adverse effects*; D010279:Parathyroid Diseases / Q000139:chemically induced; D010280:Parathyroid Glands; D012422:Rupture, Spontaneous / Q000139:chemically induced
chemical_list: D009281:Naphthalenes; D000069449:Cinacalcet