title: Occupational cooking and risk of uveal melanoma: a meta-analysis.
abstract: BACKGROUND
  Many observational studies have assessed the possible association between occupational cooking and uveal melanoma risk, but reported results are controversial. Our goal was to evaluate the association between occupational cooking and uveal melanoma risk by conducting a meta-analysis of observational studies.
  
  
  METHODS
  PubMed, EMBASE, and Web of Science were searched through June 2012 to identify all eligible studies. The pooled odds ratio (OR) with its 95% confidence interval (95%CI) was used to evaluate this association. Either a fixed- or a random-effects model were used to calculate pooled ORs.
  
  
  RESULTS
  Five case-control studies involving a total of 1,199 cases and 6,927 controls were included in the meta-analysis. Overall, occupational cooking was associated with an increased risk of uveal melanoma (OR: 1.81, 95%CI 1.33-2.46, P < 0.001). Subgroup analysis by gender suggested occupational cooking was associated with increased risk of uveal melanoma in both men (OR: 2.16, 95%CI 1.06-4.40, P = 0.034) and women (OR: 1.92, 95%CI 1.19-3.10, P = 0.008).
  
  
  CONCLUSIONS
  This meta-analysis suggests that occupational cooking is associated with an increased risk of uveal melanoma in both men and women.
authors.affiliation: Department of Ophthalmology, Jinling Hospital of Nanjing, Nanjing, China.
authors.forename: Yi-Rui
authors.initials: YR
authors.lastname: Ge
authors.forename: Nong
authors.initials: N
authors.lastname: Tian
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.forename: Qin-Rui
authors.initials: QR
authors.lastname: Hu
authors.forename: Zheng-Ping
authors.initials: ZP
authors.lastname: Huang
mesh_terms: D016022:Case-Control Studies; D003296:Cooking; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000209:etiology*; D009784:Occupational Diseases / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D011379:Prognosis; D014604:Uveal Neoplasms / Q000209:etiology*; D000098943:Uveal Melanoma