title: Exploring charged biased regions in the human proteome.
abstract: There has been an increasing interest in biased regions in proteins especially ever since it was shown that such regions are frequently associated with a structural role in the cell, or with protein disorder. In this study, we focus on charged biased protein sequences in human genome. We have identified 446 charged biased proteins within human proteome, 70% of them constitute proteins harboring negative run that correspond to transcription factor zinc finger proteins, importins and some protein kinases involving acidic activating domains. Basic charge clusters are often associated with DNA-binding, zinc-finger, basic-leucine zipper and homeobox domains. The data show that significant positive clusters correspond to ribosomal proteins. Most of proteins with zinc-binding fingers have a mixed positive and negative charged biased regions. Altogether, the Gene Ontology analysis revealed that the charged proteins are involved mainly in regulatory functions.
authors.affiliation: Molecular and Cellular Diagnosis Processes, Centre of Biotechnology of Sfax, University of Sfax, Route Sidi Mansour, Po Box 1177, 3018 Sfax, Tunisia.
authors.forename: Mouna
authors.initials: M
authors.lastname: Choura
authors.forename: Ahmed
authors.initials: A
authors.lastname: Rebaï
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D024342:Amino Acids, Acidic / Q000737:chemistry / Q000235:genetics; D024361:Amino Acids, Basic / Q000737:chemistry / Q000235:genetics; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D006801:Humans; D008954:Models, Biological; D058977:Molecular Sequence Annotation; D017434:Protein Structure, Tertiary; D020543:Proteome / Q000737:chemistry* / Q000235:genetics; D020539:Sequence Analysis, Protein
chemical_list: D024342:Amino Acids, Acidic; D024361:Amino Acids, Basic; D020543:Proteome