title: Complete response to second line Paclitaxel every 2 weeks of eyelid kaposi sarcoma: a case report.
abstract: A 77-year-old male patient presented to our attention with violaceous nodular lesions on the skin of his hands and lower extremities. Clinical and histologic examination supported the diagnosis of Kaposi sarcoma. A first-line systemic chemotherapy based on liposomal doxorubicin at a dosage of 40 mg/m2 every 3 weeks for 5 cycles was carried out, resulting in partial resolution of skin lesions. However, 1 year later, a relapse of the disease in the lower limbs and a new lesion of the left eyelid were found, therefore the patient began a second-line therapy with 100 mg/m2 paclitaxel every 2 weeks. After 8 cycles of therapy, we observed a complete remission of eyelid tumor and a partial response of lower limbs lesions up to 6 months of follow up. In conclusion, eyelid Kaposi sarcoma was successfully treated with paclitaxel every 2 weeks, obtaining a complete response.
authors.affiliation: *Scientific Direction, †Hematology Unit, ‡Medical and Experimental Oncology Unit, Cancer Institute "Giovanni Paolo II", Bari, Italy.
authors.forename: Anna Elisabetta
authors.initials: AE
authors.lastname: Brunetti
authors.forename: Attilio
authors.initials: A
authors.lastname: Guarini
authors.forename: Vito
authors.initials: V
authors.lastname: Lorusso
authors.forename: Carla
authors.initials: C
authors.lastname: Minoia
authors.forename: Angela
authors.initials: A
authors.lastname: Sabatelli
authors.forename: Ilaria
authors.initials: I
authors.lastname: Marech
authors.forename: Nicola
authors.initials: N
authors.lastname: Silvestris
mesh_terms: D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D005142:Eyelid Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000627:therapeutic use*; D012514:Sarcoma, Kaposi / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel