title: [Peculiar features of mucosal immunity in the children presenting with allergic rhinitis].
abstract: The objective of the present study was to improve the efficacy of diagnostics of various forms of allergic rhinitis (AR) in the children based on the results of investigations into specific features of mucosal immunity. Determination of IgM, IgG, IgA, sIgA and IgE, TNF-alpha, IL-1-beta, BL-4, and IFN-gamma in the nasal lavage of the children presenting with allergic rhinitis. The IgE, IgA, IgM, IgG, and albumin levels in the nasal secretion were significantly elevated during the period of exacerbation of AR in the children. Simultaneously, the production of IL-4 and TNF-alpha was enhanced whereas the TNF-gamma content remained unaltered. The efficacious treatment of allergic rhinitis resulted in the normalization of albumin, TNF-alpha, IgA, IgM, and IgG content in the nasal secretion whereas the concentration of IgE and IL-4 decreased and that of TNF-gamma increased. A failure of therapy was associated with the high level of IgE and IL-4. It is concluded that quantitative analysis of humoral immunity factors in the nasal lavage is a highly informative tool for diagnostics of allergic rhinitis in the children.
authors.forename: E D
authors.initials: ED
authors.lastname: Egorova
authors.forename: R M
authors.initials: RM
authors.lastname: Faĭzullina
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology*; D009297:Nasal Mucosa / Q000276:immunology* / Q000378:metabolism; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult
chemical_list: D016207:Cytokines