title: Integrated view of the human chromosome X-centric proteome project.
abstract: This article introduces how the human chromosome X-centric proteome project is carried out by the Japan Chromosome X Project Consortium. The inactivation of one of two chromosomes in female mammals and accumulation of genes related to neural/immune systems/tumor/testis are characteristic of chromosome X. In this Chromosome X Project, information on proteins translated from genes on chromosome X is collected by both mass spectrometry- and antibody-based proteomics. Information on the following resources is also provided: antibodies to proteins translated and full-length cDNAs transcripted from the chromosome X genes for recombinant proteins. The consortium aims to provide the following tools to search useful antibodies in the literature (Antibody Ranker), to find gene expression sites in microarray databases (Transcript Localizer) and to do advanced MRM analysis (information-based MRM).
authors.affiliation: Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata, Japan. tdsymmt@med.niigata-u.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Keiichi
authors.initials: K
authors.lastname: Nakayama
authors.forename: Hisashi
authors.initials: H
authors.lastname: Hirano
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tomonaga
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ishihama
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Yamada
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kondo
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kodera
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sato
authors.forename: Norie
authors.initials: N
authors.lastname: Araki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mamitsuka
authors.forename: Naoki
authors.initials: N
authors.lastname: Goshima
mesh_terms: D041321:Chromosomes, Human, X / Q000235:genetics / Q000378:metabolism; D016208:Databases, Factual; D005260:Female; D015870:Gene Expression; D015894:Genome, Human; D016045:Human Genome Project; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D011506:Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism; D020543:Proteome; D049951:X Chromosome Inactivation / Q000235:genetics*
chemical_list: D011506:Proteins; D020543:Proteome