title: Targeting MDSCs enhance therapeutic vaccination responses against lung cancer.
abstract: Myeloid-derived suppressor cells (MDSCs) are important regulators of immune responses. These cells suppress the cytotoxic activities of natural killer (NK)-cell and T-cell effectors and promote tumor growth. We demonstrated that depleting MDSCs improve therapeutic responses to vaccination in a murine model of lung cancer. This approach may prove beneficial against tumors in which MDSC exert prominent immunosuppressive effects.
authors.affiliation: Department of Medicine; UCLA Lung Cancer Research Program; David Geffen School of Medicine; University of California at Los Angeles; Los Angeles, CA USA ; Molecular Gene Medicine Laboratory; Veterans Affairs Greater Los Angeles Healthcare System; Los Angeles, CA USA.
authors.forename: Minu K
authors.initials: MK
authors.lastname: Srivastava
authors.forename: Steven
authors.initials: S
authors.lastname: Dubinett
authors.forename: Sherven
authors.initials: S
authors.lastname: Sharma