title: Association of pre-miR-146a rs2910164 polymorphism with the risk of head and neck cancer.
abstract: BACKGROUND
  Over- or underexpression of miR-146a has been reported in several different human tumor types, and a polymorphism in its precursor form (pre-miR-146a rs2910164 G/C) has been recently studied in connection with cancer susceptibility. The aim of the present study was to investigate the possible influence of the pre-miR-146a rs2910164 polymorphism on the risk of squamous cell carcinoma of the head and neck (HNSCC).
  
  
  METHODS
  The study included 468 patients with HNSCC and 468 cancer-free, age-, gender-, and smoking-matched controls. The miR-146a genotypes were determined using polymerase chain reaction with confronting two-pair primers, and their distribution was compared by multivariate binary logistic regression analysis.
  
  
  RESULTS
  Occurrence of heterozygous (odds ratio, OR=1.46, 95% confidence interval, CI=1.10-1.95, p=0.009) and C/C homozygous (OR=2.37, 95% CI=1.01-5.60, p=0.048) individuals was significantly more frequent among patients with HNSCC than in the control group.
  
  
  CONCLUSIONS
  The pre-miR/146a C allele may contribute to an increased susceptibility to HNSCC.
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Orsós
authors.forename: István
authors.initials: I
authors.lastname: Szanyi
authors.forename: András
authors.initials: A
authors.lastname: Csejtei
authors.forename: Imre
authors.initials: I
authors.lastname: Gerlinger
authors.forename: István
authors.initials: I
authors.lastname: Ember
authors.forename: István
authors.initials: I
authors.lastname: Kiss
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000473:pathology; D006579:Heterozygote; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012322:RNA Precursors / Q000235:genetics*; D012307:Risk Factors; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs; D012322:RNA Precursors