title: Rise of CC398 lineage of Staphylococcus aureus among Infective endocarditis isolates revealed by two consecutive population-based studies in France.
abstract: Staphylococcus aureus isolates from two prospective studies on infective endocarditis (IE) conducted in 1999 and 2008 and isolated from non-IE bacteremia collected in 2006 were spa-typed and their virulence factors were analyzed with a microarray. Both populations were genetically diverse, with no virulence factors or genotypes significantly more associated with the IE isolates compared with the non-IE isolates. The population structure of the IE isolates did not change much between 1999 and 2008, with the exception of the appearance of CC398 methicillin-susceptible Staphylococcus aureus (MSSA) isolates responsible for 5.6% of all cases in 2008. In 1999, this lineage was responsible for no cases. The increasing prevalence of S. aureus in IE is apparently not the result of a major change in staphylococcal population structure over time, with the exception of the emerging CC398 MSSA lineage.
authors.affiliation: Hospices Civils de Lyon, Centre National de Référence des Staphylocoques, Bron, France. anne.tristan@univ-lyon1.fr
authors.forename: Anne
authors.initials: A
authors.lastname: Tristan
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Rasigade
authors.forename: Esmée
authors.initials: E
authors.lastname: Ruizendaal
authors.forename: Frédéric
authors.initials: F
authors.lastname: Laurent
authors.forename: Michèle
authors.initials: M
authors.lastname: Bes
authors.forename: Hélène
authors.initials: H
authors.lastname: Meugnier
authors.forename: Gérard
authors.initials: G
authors.lastname: Lina
authors.forename: Jerome
authors.initials: J
authors.lastname: Etienne
authors.forename: Marie
authors.initials: M
authors.lastname: Celard
authors.forename: Pierre
authors.initials: P
authors.lastname: Tattevin
authors.forename: Stefan
authors.initials: S
authors.lastname: Monecke
authors.forename: Vincent
authors.initials: V
authors.lastname: Le Moing
authors.forename: François
authors.initials: F
authors.lastname: Vandenesch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D004696:Endocarditis / Q000382:microbiology*; D005260:Female; D005602:France; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000235:genetics; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D010802:Phylogeny; D013203:Staphylococcal Infections / Q000145:classification / Q000453:epidemiology; D013211:Staphylococcus aureus / Q000145:classification* / Q000235:genetics*; D037521:Virulence Factors / Q000235:genetics
chemical_list: D037521:Virulence Factors