title: Inclusion body myositis.
abstract: Sporadic inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy (IIM) after age 50 years. It presents with chronic insidious proximal leg and distal arm asymmetric muscle weakness. Despite similarities with polymyositis (PM), it is likely that IBM is primarily a degenerative disorder rather than inflammatory muscle disease. IBM is associated with a modest degree of creatine kinase (CK) elevation and an electromyogram (EMG) demonstrates a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibers often times accompanied by rimmed vacuoles. We review IBM with emphasis on recent developments in the field and discuss ongoing clinical trials.
authors.affiliation: Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Blvd, Mail Stop 2012, Kansas City, KS 66160, USA. mdimachkie@kumc.edu
authors.forename: Mazen M
authors.initials: MM
authors.lastname: Dimachkie
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Barohn
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003402:Creatine Kinase / Q000378:metabolism; D003952:Diagnostic Imaging; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology* / Q000503:physiopathology; D018979:Myositis, Inclusion Body / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*; D026741:Physical Therapy Modalities
chemical_list: D000893:Anti-Inflammatory Agents; D003402:Creatine Kinase