title: [A case report of a stage IV gastric cancer patient with rapid progression of liver metastases induced by postoperative anastomotic leakage].
abstract: The patient was a 39-year-old man with type 3 gastric cancer with synchronous multiple liver and lung metastases, who was diagnosed as cStage IV(cT4aN1M1H1). He received induction chemotherapy with S-1 and CDDP. After chemotherapy, the liver and lung metastases had disappeared completely. He underwent total gastrectomy and splenectomy, with D2 nodal dissection. Anastomotic leakage occurred on postoperative day 6, and substantial inflammatory conditions continued for 2 weeks. He died 6 weeks after surgery with multiple liver metastases. This case suggests that elevated inflammatory conditions may cause tumor progression.
authors.affiliation: Dept. of Surgical Oncology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Lee
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Kazuya
authors.initials: K
authors.lastname: Muguruma
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Sakurai
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kubo
authors.forename: Hisashi
authors.initials: H
authors.lastname: Nagahara
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kimura
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Amano
authors.forename: Eiji
authors.initials: E
authors.lastname: Noda
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Maeda
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Sawada
authors.forename: Masaichi
authors.initials: M
authors.lastname: Ohira
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000328:Adult; D057868:Anastomotic Leak / Q000209:etiology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D018450:Disease Progression; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D019300:Medical Errors; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage; D013156:Splenectomy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D017211:Treatment Failure
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin