title: Platelet rich plasma use in allograft ACL reconstructions: two-year clinical results of a MOON cohort study.
abstract: BACKGROUND
  Platelet rich plasma has been promoted as a biologic agent to enhance tissue healing. As a concentration of autologous growth factors, it has gained increased use in musculoskeletal applications.
  
  
  METHODS
  The purpose of this study was to evaluate the effect of intra-operative PRP on patient-reported outcomes 2 years after ACL reconstruction with tibialis anterior allograft. Fifty patients who underwent allograft ACL reconstruction with intra-operative application of PRP to the graft were matched with 50 allograft ACL -reconstructions without PRP use. The same surgeon performed all procedures with identical technique. Two year patient-reported outcomes including KOOS, IKDC, and Marx activity scores were obtained. Effusions in the immediate post-operative period, post-operative complications, and any subsequent procedures were also recorded.
  
  
  RESULTS
  There was no difference between the groups with respect to additional surgeries or complications in the first 2 years after reconstruction. Decreased effusions at 10±4 days were noted in the PRP group, but this difference disappeared by 8±4 weeks. No differences in patient-reported outcomes were noted in the 58 patients with two-year outcome data.
  
  
  CONCLUSIONS
  The study demonstrated that although PRP application in tibialis allograft ACL reconstructions appeared safe; clinical benefit was minor and short-term. No differences in patient-reported outcomes or number of additional surgeries at 2 years were noted.
  
  
  METHODS
  Level III - retrospective comparative study.
authors.affiliation: Department of Orthopaedics, OSU Sports Medicine, Sports Health and Performance Institute, The Ohio State University, Columbus, OH 43221, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Magnussen
authors.forename: David C
authors.initials: DC
authors.lastname: Flanigan
authors.forename: Angela D
authors.initials: AD
authors.lastname: Pedroza
authors.forename: Kate A
authors.initials: KA
authors.lastname: Heinlein
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Kaeding
mesh_terms: D000328:Adult; D064591:Allografts; D059549:Anterior Cruciate Ligament Reconstruction; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D063868:Patient Outcome Assessment; D053657:Platelet-Rich Plasma; D012189:Retrospective Studies; D013710:Tendons / Q000637:transplantation