title: Treatment results of diffuse malignant peritoneal mesothelioma.
abstract: During the last 7 years, 21 patients with DMPM were treated. Histologic types were epitheloid type in 18 patients, biphasic type in 2 patients and sarcomatoid type in 1 patient. Preoperative systemic chemotherapy, hyperthermic intraperitoneal chemotherapy(HIPEC) by laparoscopy(LHIPEC), and intraperitoneal(IP) chemotherapy were done in 14, 3 and 1 patients, respectively. Cytoreductive surgery(CRS) was done in 13 patients. Ten patients received HIPEC after CRS. Partial responses were experienced in 4 of 13 patients treated with preoperative systemic chemotherapy. One of three patients treated by LHIPEC showed complete response. Among 13 patients received laparotomy, complete removal of PC was done in 4(31%) patients. The other 9 patients who received incomplete cytoreduction had diffuse involvement on the small bowel and its mesentery. All over 5-year survival was 17%. Patients treated with HIPEC survived significantly longer than non-HIPEC group. Neoadjuvant laparoscopic HIPEC may have a great role in the preoperative control of small PC on the surface of small bowel.
authors.affiliation: Kishiwada Tokushukai Hospital, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yonemura
authors.forename: Haruaki
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Emel
authors.initials: E
authors.lastname: Canbay
authors.forename: Shozou
authors.initials: S
authors.lastname: Sako
authors.forename: Gorou
authors.initials: G
authors.lastname: Tsukiyama
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Mizumoto
authors.forename: Masumi
authors.initials: M
authors.lastname: Ichinose
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takao
authors.forename: Suguru
authors.initials: S
authors.lastname: Yabuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Hirano
authors.forename: Sachio
authors.initials: S
authors.lastname: Fushida
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Endou
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult