title: The end of mitosis from a phosphatase perspective.
abstract: Transition through mitosis, the cell division cycle phase deputed to segregate replicated chromosomes, requires a wave of protein phosphorylation. While in the past decades a wealth of information has been gathered on the major kinase activities responsible for the onset of mitosis, only recently has a picture emerged of how their effects are reversed by protein phosphatases at the end of mitosis. Here, we summarized some recent data on the relevance for protein phosphatases in the reversal of mitotic phosphorylation required to complete mitosis in vertebrate cells.
authors.affiliation: CEINGE Biotecnologie Avanzate, Naples, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Visconti
authors.forename: Luca
authors.initials: L
authors.lastname: Palazzo
authors.forename: Anna
authors.initials: A
authors.lastname: Pepe
authors.forename: Rose
authors.initials: R
authors.lastname: Della Monica
authors.forename: Domenico
authors.initials: D
authors.lastname: Grieco
mesh_terms: D000705:Anaphase; D064173:Anaphase-Promoting Complex-Cyclosome; D016203:CDC2 Protein Kinase / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism; D006801:Humans; D059566:M Phase Cell Cycle Checkpoints; D008938:Mitosis; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D010766:Phosphorylation; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D016203:CDC2 Protein Kinase; D010749:Phosphoprotein Phosphatases