title: Facial skin blood flow responses to irritant stimuli in the oral cavity.
abstract: To investigate whether capsaicin and menthol stimuli elicit characteristic responses in facial skin blood flow (SkBF), we observed the facial SkBF response to low and high concentrations of capsaicin and menthol stimuli of 1-ml solution applied to the oral cavity for 20s in 17 healthy subjects. High concentration of capsaicin significantly increased the SkBF in all of the facial areas monitored. High concentration of menthol stimulus significantly decreased SkBF in the nose and increased that in the eyelid, and upper and lower lips. These results demonstrated that capsaicin and menthol stimuli in the oral cavity elicit characteristic responses in facial SkBF.
authors.affiliation: Graduate School of Human-Environment Studies, Kyushu University, Fukuoka 816-8580, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kashima
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D002211:Capsaicin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005145:Face / Q000098:blood supply*; D005260:Female; D005421:Flavoring Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D007509:Irritants / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D007564:Japan; D007700:Kinetics; D008297:Male; D008610:Menthol / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D009061:Mouth Mucosa / Q000098:blood supply / Q000187:drug effects*; D010147:Pain Measurement; D012039:Regional Blood Flow / Q000187:drug effects*; D018689:Sensory System Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D012867:Skin / Q000098:blood supply*; D055815:Young Adult
chemical_list: D005421:Flavoring Agents; D007509:Irritants; D018689:Sensory System Agents; D008610:Menthol; D002211:Capsaicin