title: Designing of molecularly imprinted polymer-based potentiometric sensor for the determination of heparin.
abstract: A novel potentiometric sensor with high selectivity and sensitivity has been developed for the determination of heparin, based on the modification of heparin-imprinted polymer film onto a glassy carbon. The performance of the developed heparin sensor was evaluated, and the results indicated that a sensitive potentiometric sensor could be fabricated. The obtained heparin sensor shows high-selectivity monitoring of heparin, shorter response time (<4 min), wider linear range (0.003-0.7 μM), lower detection limit (0.001 μM), and satisfactory long-term stability (>2 months). The potentiometric sensor was successfully applied to the determination of heparin in heparin sodium injection with recoveries between 97.1% and 110.0%.
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Li
authors.forename: Yizeng
authors.initials: Y
authors.lastname: Liang
authors.forename: Youcai
authors.initials: Y
authors.lastname: Liu
mesh_terms: D002244:Carbon / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D005898:Glass / Q000737:chemistry; D006493:Heparin / Q000032:analysis* / Q000737:chemistry; D054802:Molecular Imprinting; D015335:Molecular Probes; D011108:Polymers / Q000737:chemistry; D011199:Potentiometry
chemical_list: D015335:Molecular Probes; D011108:Polymers; D002244:Carbon; D006493:Heparin