title: [Effect of iptkalim on myocardial enzymes and free radicals metabolism with hypoxic pulmonary hypertension].
abstract: OBJECTIVE
  To explore the effects of iptkalim on myocardial enzymes and free radicals metabolism with hypoxic pulmonary hypertension (HPH), in order to provide evidence for the mechanism of iptkalim on clinical treat.
  
  
  METHODS
  110 young men stayed at high altitude above 5 000 m were divided into iptkalim group (n = 74) and placebo group (n = 36), aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (gamma-GT), creatine kinase (CK), lactate dehydrogenase (LDH), superoxide dismutase (SOD), malonaldehyde (MDA), nitric oxide(NO) and nitric oxide synthase(NOS) were detected before and after took medicines for 6 mouths.
  
  
  RESULTS
  After took medication for 6 mouths, ALT, AST, gamma-GT, CK and LDH were reduced, SOD, NO, and NOS were increased, MDA were reduced, there were very significant difference (P < 0.05).
  
  
  CONCLUSIONS
  Oxygen free radicals have taken part in the process of HPH, iptkalim have the effect of anti-peroxidation of lipid and protect myocardial cells stress injured by hypoxia which related with mitochondrial membrane and cell membrane's K(ATP) channel activation.
authors.affiliation: The 18th Hospital of PLA, Xinjiang Yecheng 844900, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Cui
authors.forename: Liang
authors.initials: L
authors.lastname: Gao
authors.forename: Dong-Xiang
authors.initials: DX
authors.lastname: Zhang
authors.forename: Zhong-Hai
authors.initials: ZH
authors.lastname: Xiao
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Yang
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Guang-Quan
authors.initials: GQ
authors.lastname: Ma
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000531:Altitude; D003402:Creatine Kinase / Q000097:blood; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000209:etiology / Q000378:metabolism*; D000860:Hypoxia / Q000150:complications; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D015221:Potassium Channels / Q000819:agonists*; D011437:Propylamines / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D005609:Free Radicals; C502260:N-(1-methylethyl)-1,1,2-trimethylpropylamine; D015221:Potassium Channels; D011437:Propylamines; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase