title: Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore.
abstract: In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore, a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches chromosomes to spindle microtubules, modulates the stability of these attachments and relays the microtubule-binding status to the spindle assembly checkpoint (SAC), a cell cycle surveillance pathway that delays chromosome segregation in response to unattached kinetochores. Recent studies are shaping current thinking on how each of these kinetochore-centred processes is achieved, and how their integration ensures faithful chromosome segregation, focusing on the essential roles of kinase-phosphatase signalling and the microtubule-binding KMN protein network.
authors.affiliation: Cell Biology Program, Sloan-Kettering Institute, 1275 York Ave. New York, New York 10065, USA. foleye1@mskcc.org
authors.forename: Emily A
authors.initials: EA
authors.lastname: Foley
authors.forename: Tarun M
authors.initials: TM
authors.lastname: Kapoor
mesh_terms: D002455:Cell Division; D020090:Chromosome Segregation; D003598:Cytoskeletal Proteins; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D059566:M Phase Cell Cycle Checkpoints; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis; D009687:Nuclear Proteins / Q000378:metabolism; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism
chemical_list: D003598:Cytoskeletal Proteins; C472643:Knl1 protein, human; C492664:MIS12 protein, human; D008869:Microtubule-Associated Proteins; C120529:NDC80 protein, human; D009687:Nuclear Proteins