title: [Current status and treatment results of combined modality therapy for locally recurrent rectal cancer].
abstract: OBJECTIVE
  The aim of this study was to clarify the current status of combined modality therapy for locally recurrent rectal cancer.
  
  
  METHODS
  Between 2000 and 2011, 43 patients(26 men and 17 women; mean age, 60 years) developed local pelvic recurrence after curative surgery. The recurrence pattern was almost equally distributed as 53% (23/43) pelvic, and 47% (20/43) pelvic and metastatic disease. Regarding the form of local recurrence, localized type and lateral spread type were present in 25 and 18 patients, respectively. In all, 24 patients underwent surgical resection for recurrent disease, and 87% of these patients underwent potentially curative surgery. The 3- and 5-year overall survival rates for patients who were treated with surgical resection were 42% and 29%, respectively. These results were significantly favorable when compared to the non-surgical group of patients who were treated with chemoradiotherapy or chemotherapy. Localized type recurrence is a statistically significant prognostic factor for improved survival compared to lateral spread type recurrence.
  
  
  CONCLUSIONS
  Preoperative chemoradiotherapy and surgical resection should be a standard treatment option for patients with localized type recurrence, and chemoradiotherapy is better indicated for patients with lateral spread type recurrence.
authors.affiliation: Dept. of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Japan.
authors.forename: Motoi
authors.initials: M
authors.lastname: Koyama
authors.forename: Akihiro
authors.initials: A
authors.lastname: Murata
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Hajime
authors.initials: H
authors.lastname: Morohashi
authors.forename: Harue
authors.initials: H
authors.lastname: Akasaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Yoshiomi
authors.initials: Y
authors.lastname: Hatayama
authors.forename: Hideo
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hakamada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D012004:Rectal Neoplasms / Q000628:therapy*