title: Comparison of tissue oxygenation and compartment pressure following tibia fracture.
abstract: OBJECTIVE
  We investigated the ability of direct continuous measurement of intramuscular tissue oxygenation (PmO(2)) to detect acute ischaemia in the leg in patients at risk for acute extremity compartment syndrome. Following tibia fracture treated by intramedullary nailing, we compared the proportions of PmO(2) and compartment pressure (CP) measurements that met the warning criteria for compartment syndrome.
  
  
  METHODS
  Participants included 10 patients sustaining acute isolated closed tibia shaft fractures treated by intramedullary nailing. A tissue oxygenation probe and a CP probe were percutaneously placed into the anterior compartment of the leg. PmO(2) and CP in the anterior compartment were measured in the injured leg for 48 h postoperatively. Measurements meeting the warning criteria were defined as PmO(2) < 10 mmHg, CP > 30 mmHg and perfusion pressure ΔP < 30 mmHg.
  
  
  RESULTS
  None of the patients developed compartment syndrome. Comparison of CP and PmO(2) showed a CP > 30 mmHg in 50.39% of CP measurements in all patients and a PmO(2) < 10 mmHg in 0.75% of PmO(2) measurements in two patients (P = 0.005). Comparison of ΔP and PmO(2) showed a ΔP < 30 mmHg in 31.01% of ΔP measurements in nine patients and a PmO(2) < 10 mmHg in 0.76% of PmO(2) measurements in one patient (P = 0.01).
  
  
  CONCLUSIONS
  In the absence of compartment syndrome, pressure measurements following tibia fracture treated with intramedullary nailing often met the warning criteria, whereas PmO(2) did not, suggesting that measurement of intramuscular tissue oxygenation may represent a potential method for the identification of acute compartment syndrome that deserves continued investigation.
authors.affiliation: Department of Orthopaedic Surgery, University of California, San Francisco, CA, USA.
authors.forename: Erik N
authors.initials: EN
authors.lastname: Hansen
authors.forename: Givenchy
authors.initials: G
authors.lastname: Manzano
authors.forename: Utku
authors.initials: U
authors.lastname: Kandemir
authors.forename: James M
authors.initials: JM
authors.lastname: Mok
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003161:Compartment Syndromes / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D005594:Fracture Fixation, Intramedullary; D005596:Fractures, Closed / Q000601:surgery; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D011184:Postoperative Period; D011312:Pressure; D013978:Tibial Fractures / Q000097:blood / Q000150:complications / Q000601:surgery*
chemical_list: D010100:Oxygen