title: No long-term feeding toxicities on the health status in rats fed with cloned Korean native beef cattle (Hanwoo) meat.
abstract: This study was designed to undertake a risk assessment to identify the health status of rats fed with somatic cell nuclear transfer (SCNT)-cloned Korean native beef cattle (Hanwoo) meat for 26 weeks. The rats were randomly divided into 5 groups, each consisting of 12 male (142.6 ± 5.23 g) and 12 female (113.7 ± 6.31 g) rats each. The animals were fed commercial pellets (control), pellets containing 5% (N-5) and 10% (N-10) of normal cattle meat, and diets containing 5% (C-5) and 10% (C-10) of cloned cattle meat. The mortality; clinical signs; body weight; food consumption; urinary, hematology, blood biochemistry, and histopathological analyses; and absolute and relative organ weights were analyzed and compared. During the 26-week test period, health status-related factors of the rats fed on cloned Hanwoo meat were found to have no test substance-related toxicities. The only difference was the increased uterus weight in female C-10 rats as compared to their counterparts counterparts (p < .05). On the basis of these health status results, it can be postulated that no food consumption risks might arise from the long-term feeding of cloned cattle meat in rats.
authors.affiliation: College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Chungbuk, Republic of Korea.
authors.forename: Nam-Jin
authors.initials: NJ
authors.lastname: Lee
authors.forename: Byoung-Chul
authors.initials: BC
authors.lastname: Yang
authors.forename: Gi-Sun
authors.initials: GS
authors.lastname: Im
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Lee
authors.forename: Hwan-Hoo
authors.initials: HH
authors.lastname: Seong
authors.forename: Jin-Ki
authors.initials: JK
authors.lastname: Park
authors.forename: Won-Kyong
authors.initials: WK
authors.lastname: Chang
authors.forename: Jong-Koo
authors.initials: JK
authors.lastname: Kang
authors.forename: Seongsoo
authors.initials: S
authors.lastname: Hwang
mesh_terms: D000704:Analysis of Variance; D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001835:Body Weight / Q000187:drug effects; D002417:Cattle; D019976:Cloning, Organism; D004435:Eating / Q000187:drug effects; D005260:Female; D030841:Food, Genetically Modified / Q000633:toxicity*; D006304:Health Status; D008297:Male; D008460:Meat / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018675:Toxicity Tests
chemical_list: D015415:Biomarkers