title: New clinical pathways for keratoconus.
abstract: Pre-2000, the clinical management of keratoconus centred on rigid contact lens fitting when spectacle corrected acuity was no longer adequate, and transplantation where contact lens wear failed. Over the last decade, outcome data have accumulated for new interventions including corneal collagen crosslinking, intracorneal ring implantation, topographic phototherapeutic keratectomy, and phakic intraocular lens implantation. We review the current evidence base for these interventions and their place in new management pathways for keratoconus under two key headings: corneal shape stabilisation and visual rehabilitation.
authors.affiliation: Moorfields Eye Hospital, London, UK. dan.gore@moorfields.nhs.uk
authors.forename: D M
authors.initials: DM
authors.lastname: Gore
authors.forename: A J
authors.initials: AJ
authors.lastname: Shortt
authors.forename: B D
authors.initials: BD
authors.lastname: Allan
mesh_terms: D003094:Collagen / Q000378:metabolism*; D003131:Combined Modality Therapy; D003315:Cornea / Q000378:metabolism; D003319:Corneal Stroma / Q000378:metabolism / Q000601:surgery*; D019091:Critical Pathways; D003432:Cross-Linking Reagents / Q000627:therapeutic use*; D006801:Humans; D007640:Keratoconus / Q000503:physiopathology / Q000628:therapy*; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D014786:Vision Disorders / Q000534:rehabilitation
chemical_list: D003432:Cross-Linking Reagents; D003094:Collagen