title: Maternal hypertensive disorders in pregnancy and self-reported cognitive impairment of the offspring 70 years later: the Helsinki Birth Cohort Study.
abstract: OBJECTIVE
  We tested whether maternal hypertensive disorders during pregnancy predict self-reported cognitive impairment, which is one of the earliest behavioral markers of dementia, of the offspring 70 years later.
  
  
  METHODS
  We included 876 participants of the Helsinki Birth Cohort Study 1934-44 who were born after normotensive, preeclamptic, or hypertensive pregnancies that were defined by the use of the mother's blood pressure and urinary protein measurements at maternity clinics and birth hospitals. The participants completed a psychological questionnaire that included questions on cognitive failures and dysexecutive functioning at an average age of 69.3 ± 3.1 (SD) years.
  
  
  RESULTS
  In comparison with the offspring who were born after normotensive pregnancies, the offspring who were born after preeclamptic pregnancies reported more frequent complaints of cognitive failures, distractibility, and false triggering. Further, among women we found maternal hypertension without proteinuria that was associated with more frequent complaints of cognitive failures, forgetfulness, and false triggering.
  
  
  CONCLUSIONS
  Hypertensive disorders during pregnancy are associated with more frequent subjective complaints of cognitive failures of the offspring in old age.
authors.affiliation: Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.
authors.forename: Soile
authors.initials: S
authors.lastname: Tuovinen
authors.forename: Johan G
authors.initials: JG
authors.lastname: Eriksson
authors.forename: Eero
authors.initials: E
authors.lastname: Kajantie
authors.forename: Jari
authors.initials: J
authors.lastname: Lahti
authors.forename: Anu-Katriina
authors.initials: AK
authors.lastname: Pesonen
authors.forename: Kati
authors.initials: K
authors.lastname: Heinonen
authors.forename: Clive
authors.initials: C
authors.lastname: Osmond
authors.forename: David J P
authors.initials: DJ
authors.lastname: Barker
authors.forename: Katri
authors.initials: K
authors.lastname: Räikkönen
mesh_terms: D000368:Aged; D001724:Birth Weight / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology; D015331:Cohort Studies; D005260:Female; D005387:Finland; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*; D012307:Risk Factors; D057566:Self Report