title: Expression of cyclin E in stage III colorectal carcinoma.
abstract: Carcinogenesis is characterized by an abnormal regulation of the cell cycle. Regulators of the cell cycle such as cyclin E play an important role in neoplasia and may be correlated with prognosis. The clinical significance of the expression of cyclin E in stage III colorectal carcinoma has not yet been investigated. The expression of cyclin E was evaluated in 49 patients. Using a multivariate analysis, the expression of cyclin E in the tumor at diagnosis was compared with various clinicopathological variables, including age, gender, tumor site, tumor size, tumor differentiation and lymph node involvement. There were more node-positive cases in the cyclin E-negative group than in the cyclin E-positive group (P=0.003). However, there was no correlation between the degree of cyclin E expression and the clinical data. In conclusion, our data suggest that overexpression of cyclin E does not predict the clinical outcome in colorectal cancer stage III. Negative cyclin E staining may be associated with lymph node involvement.
authors.affiliation: Departments of Pathology ; Sackler School of Medicine, Tel-Aviv University, Ramat-Aviv,  Israel.
authors.forename: Lea
authors.initials: L
authors.lastname: Rath-Wolfson
authors.forename: Michael
authors.initials: M
authors.lastname: Bergman
authors.forename: Yaacov
authors.initials: Y
authors.lastname: Ori
authors.forename: Alex
authors.initials: A
authors.lastname: Goldman
authors.forename: Edward
authors.initials: E
authors.lastname: Ram
authors.forename: Rumelia
authors.initials: R
authors.lastname: Koren
authors.forename: Hertzel
authors.initials: H
authors.lastname: Salman