title: Associations between the genotypes and phenotype of CYP3A and the lipid response to simvastatin in Chinese patients with hypercholesterolemia.
abstract: OBJECTIVE
  This study examined the associations between the CYP3A4*1G, CYP3A4*22, CYP3A5*3 and PPARA rs4823613 A>G polymorphisms and the phenotypes of CYP3A estimated by the ratio of 6β-hydroxycortisol:cortisol in urine, and the low-density lipoprotein cholesterol response to simvastatin in Chinese patients with hypercholesterolemia.
  
  
  METHODS
  Lipid profiles were determined off treatment and after 6 weeks of treatment with simvastatin 40 mg in 273 patients.
  
  
  RESULTS
  There was no significant association between the ratio of 6β-hydroxycortisol:cortisol and the low-density lipoprotein cholesterol response to simvastatin in the study subjects (r = 0.052; p = 0.455). The genetic polymorphisms examined had no significant association with this measure of CYP3A phenotype or the lipid-lowering responses to simvastatin.
  
  
  CONCLUSIONS
  The results of this study suggest that genetic polymorphisms in CYP3A or other regulatory genes, or the CYP3A activity itself, is unlikely to have a significant effect on the lipid-lowering responses to simvastatin in Chinese patients.
authors.affiliation: Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR.
authors.forename: Miao
authors.initials: M
authors.lastname: Hu
authors.forename: Valiant Wl
authors.initials: VW
authors.lastname: Mak
authors.forename: Yajie
authors.initials: Y
authors.lastname: Xiao
authors.forename: Brian
authors.initials: B
authors.lastname: Tomlinson
mesh_terms: D044466:Asian People; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D051544:Cytochrome P-450 CYP3A / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005838:Genotype; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000652:urine; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000201:enzymology* / Q000235:genetics; D050356:Lipid Metabolism / Q000187:drug effects / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D019821:Simvastatin / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D014280:Triglycerides; C001380:6 beta-hydroxycortisol; D019821:Simvastatin; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; D006854:Hydrocortisone