title: Evaluation and management of vertebral compression fractures.
abstract: Compression fractures affect many individuals worldwide. An estimated 1.5 million vertebral compression fractures occur every year in the US. They are common in elderly populations, and 25% of postmenopausal women are affected by a compression fracture during their lifetime. Although these fractures rarely require hospital admission, they have the potential to cause significant disability and morbidity, often causing incapacitating back pain for many months. This review provides information on the pathogenesis and pathophysiology of compression fractures, as well as clinical manifestations and treatment options. Among the available treatment options, kyphoplasty and percutaneous vertebroplasty are two minimally invasive techniques to alleviate pain and correct the sagittal imbalance of the spine.
authors.affiliation: University of California Irvine Medical Center in Orange, CA, USA. danielaa@uci.edu
authors.forename: Daniela
authors.initials: D
authors.lastname: Alexandru
authors.forename: William
authors.initials: W
authors.lastname: So
mesh_terms: D000367:Age Factors; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D050815:Fractures, Compression / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D005598:Fractures, Spontaneous / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D058498:Kyphoplasty / Q000379:methods; D008297:Male; D058866:Osteoporotic Fractures / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors; D016103:Spinal Fractures / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D014057:Tomography, X-Ray Computed / Q000379:methods; D054854:Vertebroplasty / Q000379:methods
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates