title: The treatment of bovine sarcoptic mange (Sarcoptes scabiei var. bovis) using eprinomectin extended-release injection.
abstract: The efficacy of eprinomectin in an extended-release injection (ERI) formulation was evaluated in cattle harbouring induced infestations of Sarcoptes scabiei var. bovis (sarcoptic mange) in three studies conducted in Germany (two studies) and Austria (one study). A total of 44 cattle were included in the studies, 12 in one study and 16 in each of the other two studies. Approximately eight weeks following initial induced infestation, cattle in each study were formed into replicates of two animals each on the basis of pre-treatment bodyweights. Within replicates the animals were randomly allocated to one of two treatments: ERI vehicle (control) or Eprinomectin 5% (w/v) ERI (1.0 mg eprinomectin/kg). Treatments were administered at 1 mL/50 kg bodyweight by subcutaneous injection in front of the shoulder once on day 0. The number of live mites in skin scrapings was determined prior to treatment and at weekly intervals for eight weeks after treatment. Severity of skin lesions was evaluated and scored when skin scrapings were taken. In all studies, animals were weighed before infestation and again prior to and at 56 days after treatment. Mite counts for treated cattle were significantly (p<0.05) lower than counts for controls from Day 7 onwards. Cattle treated with Eprinomectin ERI were Sarcoptes mite-free from seven, 21 or 28 days post-treatment to the end of the study in the three studies, and lesions regressed accordingly. Mean weight gain over the post-treatment period was significantly higher for treated cattle than for controls in two studies. All animals accepted the treatment well.
authors.affiliation: Merial GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101 Rohrdorf, Germany. martin.visser@merial.com
authors.forename: M
authors.initials: M
authors.lastname: Visser
authors.forename: M
authors.initials: M
authors.lastname: Löwenstein
authors.forename: S
authors.initials: S
authors.lastname: Yoon
authors.forename: S
authors.initials: S
authors.lastname: Rehbein
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001733:Bites and Stings; D002417:Cattle; D005260:Female; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D011897:Random Allocation; D012520:Sarcoptes scabiei / Q000502:physiology; D012532:Scabies / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin; C101434:eprinomectin