title: T-cell infiltration correlates with CXCL10 expression in ganglia of cynomolgus macaques with reactivated simian varicella virus.
abstract: Ganglia of monkeys with reactivated simian varicella virus (SVV) contained more CD8 than CD4 T cells around neurons. The abundance of CD8 T cells was greater less than 2 months after reactivation than that at later times and correlated with that of CXCL10 RNA but not with those of SVV protein or open reading frame 61 (ORF61) antisense RNA. CXCL10 RNA colocalized with T-cell clusters. After SVV reactivation, transient T-cell infiltration, possibly mediated by CXCL10, parallels varicella zoster virus (VZV) reactivation in humans.
authors.affiliation: Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Werner J D
authors.initials: WJ
authors.lastname: Ouwendijk
authors.forename: Allison
authors.initials: A
authors.lastname: Abendroth
authors.forename: Vicki
authors.initials: V
authors.lastname: Traina-Dorge
authors.forename: Sarah
authors.initials: S
authors.lastname: Getu
authors.forename: Megan
authors.initials: M
authors.lastname: Steain
authors.forename: Mary
authors.initials: M
authors.lastname: Wellish
authors.forename: Arno C
authors.initials: AC
authors.lastname: Andeweg
authors.forename: Albert D M E
authors.initials: AD
authors.lastname: Osterhaus
authors.forename: Don
authors.initials: D
authors.lastname: Gilden
authors.forename: Georges M G M
authors.initials: GM
authors.lastname: Verjans
authors.forename: Ravi
authors.initials: R
authors.lastname: Mahalingam
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000378:metabolism*; D004279:DNA, Viral / Q000235:genetics; D005724:Ganglia / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D006566:Herpesviridae Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology*; D008252:Macaca fascicularis; D009474:Neurons / Q000276:immunology* / Q000821:virology; D016366:Open Reading Frames; D016372:RNA, Antisense / Q000096:biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018140:Varicellovirus / Q000235:genetics / Q000276:immunology* / Q000378:metabolism* / Q000502:physiology*; D019562:Viral Load; D014775:Virus Activation; D017735:Virus Latency / Q000235:genetics
chemical_list: D054357:Chemokine CXCL10; D004279:DNA, Viral; D016372:RNA, Antisense; D012333:RNA, Messenger