title: [Review of chemoradiotherapy followed by surgical resection in locally advanced non-small-cell lung cancer].
abstract: Chemoradiotherapy is recommended for locally advanced non-small-cell lung cancer(NSCLC). However, the overall median survival time remains poor(<20 months). We evaluated the outcome and complications of chemoradiotherapy, followed by surgical resection, in locally advanced NSCLC. Eight patients(7 men and 1 woman; median age, 59.5 years (range, 47-68 years) who underwent chemoradiotherapy followed by surgical resection for locally advanced NSCLC from 2002 to 2011 were retrospectively analyzed. In all cases, chemotherapy consisted of platinum-based combination therapy. Postoperatively, bronchopleural fistula occurred in 1 patient and Horner syndrome was observed in 1 patient. No treatment -related deaths were observed. The median of progression-free survival was 34.2 months. In conclusion, chemoradiotherapy should be the standard of care for locally advanced NSCLC. Trimodality therapy is still experimental but seems to be promising for certain subgroups of patients with locally advanced NSCLC.
authors.affiliation: Dept. of Respiratory Medicine and Medical Oncology, Gifu Municipal Hospital, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Futamura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sawa
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Akane
authors.initials: A
authors.lastname: Horiba
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishiguro
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yoshida
authors.forename: Tatsuomi
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Marui
authors.forename: Eiji
authors.initials: E
authors.lastname: Murakami
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Azuma
authors.forename: Shinji
authors.initials: S
authors.lastname: Murakawa
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Iida
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies