title: Oralair(®): a causal treatment for grass pollen-induced allergic rhinoconjunctivitis.
abstract: Grass pollen-induced allergic rhinoconjunctivitis is a common disease, comprising more than just the classic symptoms of nasal obstruction, sneezing, rhinorrhea and itchy, watery eyes. Sufferers deal with severe impairments in daily life. Allergic rhinoconjunctivitis is also considered an important risk factor in the development of asthma. Allergen avoidance, medication for symptomatic treatment and allergen-specific immunotherapy are cornerstones in therapeutic management, but immunotherapy is the only available treatment that is able to affect the natural course of allergy. In recent decades, clinical trials have investigated the efficacy and safety of subcutaneous immunotherapy. To date, efforts have been made to develop more convenient routes of administration. Substantial improvement may be achieved through the application of sublingual tablets. This article discusses the development process of immunotherapy and the clinical background of the Oralair(®) (Stallergènes, Hauts-de-Seine, France) five-grass pollen tablet. Furthermore, it outlines this tablet's efficacy and safety properties.
authors.affiliation: Schumpeter School of Business & Economics, University of Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany. koeberle@uni-wuppertal.de
authors.forename: Juliane
authors.initials: J
authors.lastname: Köberlein
authors.forename: Ralph
authors.initials: R
authors.lastname: Mösges
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003233:Conjunctivitis, Allergic / Q000209:etiology / Q000276:immunology / Q000628:therapy; D003888:Desensitization, Immunologic / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D006109:Poaceae / Q000276:immunology*; D011058:Pollen / Q000276:immunology*; D016032:Randomized Controlled Trials as Topic; D006255:Rhinitis, Allergic, Seasonal / Q000209:etiology / Q000276:immunology / Q000628:therapy; D013607:Tablets / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D013607:Tablets