title: LRSAM1, an E3 Ubiquitin ligase with a sense for bacteria.
abstract: Antimicrobial autophagy is a host cellular process that captures and delivers intracellular parasites to lysosomes following their targeting as cargo via ubiquitination. Huett et al. (2012) show that the LRR- and RING-domain-containing E3 ubiquitin ligase LRSAM1 recognizes various bacteria and generates a ubiquitin signal that initiates the autophagic cascade.
authors.affiliation: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. jcelli@niaid.nih.gov
authors.forename: Jean
authors.initials: J
authors.lastname: Celli
mesh_terms: D001419:Bacteria; D006801:Humans; D012486:Salmonella typhimurium / Q000276:immunology*; D025801:Ubiquitin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases