title: Probing highly selective H/D exchange processes with a ruthenium complex through neutron diffraction and multinuclear NMR studies.
abstract: Deuterium labeling is a powerful way to gain mechanistic information in biology and chemistry. However, selectivity is hard to control experimentally, and labeled sites can be difficult to assign both in solution and in the solid state. Here we show that very selective high-deuterium contents can be achieved for the polyhydride ruthenium phosphine complex [RuH2(H2)2(PCyp3)2] (1) (PCyp3 = P(C5H9)3). The selectivity of the H/D exchange process is demonstrated by multinuclear NMR and neutron diffraction analyses. It has also been investigated through density functional theory (DFT) calculations. The reactions are performed under mild conditions at room temperature, and the extent of deuterium incorporation, involving selective C-H bond activation within the cyclopentyl rings of the phosphine ligands, can easily be tuned (solvent effects, D2 pressure). It is shown that D2 gas can inhibit the C-H/C-D exchange process.
authors.affiliation: CNRS , LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse Cedex 4, France. grellier@lcc-toulouse.fr
authors.forename: Mary
authors.initials: M
authors.lastname: Grellier
authors.forename: Sax A
authors.initials: SA
authors.lastname: Mason
authors.forename: Alberto
authors.initials: A
authors.lastname: Albinati
authors.forename: Silvia C
authors.initials: SC
authors.lastname: Capelli
authors.forename: Silvia
authors.initials: S
authors.lastname: Rizzato
authors.forename: Christian
authors.initials: C
authors.lastname: Bijani
authors.forename: Yannick
authors.initials: Y
authors.lastname: Coppel
authors.forename: Sylviane
authors.initials: S
authors.lastname: Sabo-Etienne