title: Bloodless lung transplantation in Jehovah's Witnesses: impact on perioperative parameters and outcome compared with a matched control group.
abstract: BACKGROUND
  Jehovah's Witnesses (JW) refuse to receive blood products due to their religious beliefs. Bloodless transplantation programs have made the successful transplantation of solid organs like heart, liver, kidney, and pancreas in JW feasible. In this study we present the third and fourth case of a successful bloodless lung transplantation and analyze perioperative parameters and outcome with a strictly selected matched control group (CG).
  
  
  METHODS
  Two JW patients suffering from idiopathic pulmonary fibrosis had single lung transplantation in the transfusion-free program. Ten of 113 patients (8.8%) undergoing lung transplantation fulfilled the matching criteria and served as CG. Perioperative parameters including blood loss and transfusions were collected from the charts. Regarding outcome parameters arterial blood gas, lung function testing, length of stay, and survival were analyzed.
  
  
  RESULTS
  Concerning perioperative parameters no significant differences could be found between both groups except for the creatinine level, which was significantly lower in the JW group on postoperative day 0 (P = .037), and the hemoglobin and hematocrit levels, which were significantly higher in the JW group on postoperative day 3 (P = .032 and P = .041, respectively). The analysis of the outcome parameters revealed significantly higher postoperative lung functional testing values forced expiratory volume after 1 second (FEV1) and forced vital capacity (FVC) in the JW group compared with the CG (P = .037 and P = .036, respectively).
  
  
  CONCLUSIONS
  Bloodless lung transplantation is feasible in carefully selected JW recipients. Comparing JW to CG, no statistically significant difference in the perioperative course and a trend towards a favorable postoperative lung function outcome were detected.
authors.affiliation: Methodist Hospital, DeBakey Heart & Vascular Center, Department of Cardiovascular Surgery, Houston, Texas 77030, USA.
authors.forename: S
authors.initials: S
authors.lastname: Partovi
authors.forename: B A
authors.initials: BA
authors.lastname: Bruckner
authors.forename: D
authors.initials: D
authors.lastname: Staub
authors.forename: G
authors.initials: G
authors.lastname: Ortiz
authors.forename: S A
authors.initials: SA
authors.lastname: Scheinin
authors.forename: H
authors.initials: H
authors.lastname: Seethamraju
authors.forename: M
authors.initials: M
authors.lastname: Loebe
mesh_terms: D000368:Aged; D001294:Attitude to Health; D001803:Blood Transfusion; D016022:Case-Control Studies; D003422:Critical Care; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000601:surgery*; D033221:Jehovah's Witnesses; D007902:Length of Stay; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000378:metabolism; D010342:Patient Acceptance of Health Care; D059035:Perioperative Period; D013997:Time Factors; D016896:Treatment Outcome; D014797:Vital Capacity
chemical_list: D010100:Oxygen