title: [A case of gastric endocrine cell carcinoma that responded to chemotherapy with CPT-11+CDDP].
abstract: A 57-year-old male patient was referred to our department with a diagnosis of #3 lymph node recurrence of early gastric cancer after treatment of endoscopic submucosal dissection (ESD). The pathological diagnosis of the ESD specimen was neuroendocrine cell carcinoma of the stomach with positive immunohistochemical staining of chromogranin A. The diameter of the tumor was 10 mm and the depth of invasion was pSM2. Distal partial gastrectomy with standard lymph node dissection (D2) was performed. The pathological findings were negative for malignancy in the resected stomach and positive in 2 of the #3 lymph nodes. Adjuvant chemotherapy of S-1 was administered, but a recurrence in the paraaortic lymph nodes was revealed by follow up X-ray computed tomography (X-CT) 3 months later. The case was considered as a S-1 failure, and the chemotherapy was changed to the irinotecan(CPT-11) +cisplatin(CDDP). A clinical complete response (CR) was obtained after two courses and maintained for up to twenty months.
authors.affiliation: Dept. of Surgical Oncology, Kanazawa Medical University, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kinami
authors.forename: Emi
authors.initials: E
authors.lastname: Morioka
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kaida
authors.forename: Yukako
authors.initials: Y
authors.lastname: Ohno
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Tomita
authors.forename: Miki
authors.initials: M
authors.lastname: Noguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Funaki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Omote
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nakano
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Ueda
authors.forename: Takeo
authors.initials: T
authors.lastname: Kosaka
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004701:Endocrine Gland Neoplasms / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D000077146:Irinotecan; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin