title: Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents.
abstract: A total of 29 novel sulfenamide compounds were synthesized, spectroscopically characterized and evaluated in vitro for antimicrobial activity against various infectious pathogens. Compounds 1b and 2c exhibited potent inhibition against clinical Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentration (MIC) values of 1.56 μg/mL.
authors.affiliation: State-Key Laboratory and Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Shang
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.forename: Zai-Shun
authors.initials: ZS
authors.lastname: Li
authors.forename: Biao
authors.initials: B
authors.lastname: Ren
authors.forename: Zheng-Ming
authors.initials: ZM
authors.lastname: Li
authors.forename: Huan-qin
authors.initials: HQ
authors.lastname: Dai
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Zhang
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013416:Sulfamerazine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; C471392:sulfenamide; D013416:Sulfamerazine