title: Multiple gingival metastasis of adenocarcinoma of the lung.
abstract: Metastasis to the gingival soft tissues is an extremely rare phenomenon, and metastasis of multiple lesions (i.e. more than 2 lesions), is even more hard to find. In this study, we have reported a rare case of lung adenocarcinoma, which metastasized to the maxillary (2 lesions) and mandibular gingivae (1 lesion) in a 57 year old male patient. Metastasis was also seen to the vertebrae. The differential diagnosis consisted of acute myelomonocytic leukemia, chronic lymphocytic leukemia, haemangioma, pyogenic granuloma, giant cell granuloma, peripheral fibroma, primary gingival carcinoma and secondary metastasis. Contrast enhanced computed tomography of the lung showed a well-defined mass situated below the right hilum with lower lobe consolidation and pleural effusion on the right side with dorsal spinal metastasis. Excisional biopsy of the lesions was consistent with the diagnosis, and the immunohistochemical analysis was positive for cytokeratin 7, carcinoembryonic antigen (CEA), thyroid transforming factor 1 (TTF1), and negative for vimentin and cytokeratin 20 (CK20).
authors.affiliation: Department of Oral Medicine and Radiology, Kothiwal Dental College and Research Centre, Moradabad, India.
authors.forename: S M
authors.initials: SM
authors.lastname: Ravi Prakash
authors.forename: Sankalp
authors.initials: S
authors.lastname: Verma
authors.forename: Navneet
authors.initials: N
authors.lastname: Gill
authors.forename: Vibha
authors.initials: V
authors.lastname: Malik
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003287:Contrast Media; D004268:DNA-Binding Proteins / Q000032:analysis; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005887:Gingival Neoplasms / Q000556:secondary*; D006801:Humans; D053554:Keratin-20 / Q000032:analysis; D053552:Keratin-7 / Q000032:analysis; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008334:Mandible / Q000473:pathology; D008437:Maxilla / Q000473:pathology; D008875:Middle Aged; D013125:Spinal Neoplasms / Q000556:secondary; D014057:Tomography, X-Ray Computed / Q000379:methods; D014157:Transcription Factors; D014746:Vimentin / Q000032:analysis
chemical_list: D002272:Carcinoembryonic Antigen; D003287:Contrast Media; D004268:DNA-Binding Proteins; D053554:Keratin-20; D053552:Keratin-7; C504003:TTF1 protein, human; D014157:Transcription Factors; D014746:Vimentin