title: State-of-the-art treatment alternatives for base of skull meningiomas: complementing and controversial indications for neurosurgery, stereotactic and robotic based radiosurgery or modern fractionated radiation techniques.
abstract: For skull base meningiomas, several treatment paradigms are available: Observation with serial imaging, surgical resection, stereotactic radiosurgery, radiation therapy or some combination of both. The choice depends on several factors. In this review we evaluate different treatment options, the outcome of modern irradiation techniques as well as the clinical results available, and establish recommendations for the treatment of patients with skull-base meningiomas.
authors.affiliation: Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. Stephanie.Combs@med.uni-heidelberg.de
authors.forename: Stephanie E
authors.initials: SE
authors.lastname: Combs
authors.forename: Ute
authors.initials: U
authors.lastname: Ganswindt
authors.forename: Robert L
authors.initials: RL
authors.lastname: Foote
authors.forename: Douglas
authors.initials: D
authors.lastname: Kondziolka
authors.forename: Jörg-Christian
authors.initials: JC
authors.lastname: Tonn
mesh_terms: D019583:Dose Fractionation, Radiation; D006801:Humans; D008579:Meningioma / Q000532:radiotherapy* / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods; D012371:Robotics / Q000379:methods; D019292:Skull Base Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D016896:Treatment Outcome