title: A fresh look at the male-specific region of the human Y chromosome.
abstract: The Chromosome-centric Human Proteome Project (C-HPP) aims to systematically map the entire human proteome with the intent to enhance our understanding of human biology at the cellular level. This project attempts simultaneously to establish a sound basis for the development of diagnostic, prognostic, therapeutic, and preventive medical applications. In Iran, current efforts focus on mapping the proteome of the human Y chromosome. The male-specific region of the Y chromosome (MSY) is unique in many aspects and comprises 95% of the chromosome's length. The MSY continually retains its haploid state and is full of repeated sequences. It is responsible for important biological roles such as sex determination and male fertility. Here, we present the most recent update of MSY protein-encoding genes and their association with various traits and diseases including sex determination and reversal, spermatogenesis and male infertility, cancers such as prostate cancers, sex-specific effects on the brain and behavior, and graft-versus-host disease. We also present information available from RNA sequencing, protein-protein interaction, post-translational modification of MSY protein-coding genes and their implications in biological systems. An overview of Human Y chromosome Proteome Project is presented and a systematic approach is suggested to ensure that at least one of each predicted protein-coding gene's major representative proteins will be characterized in the context of its major anatomical sites of expression, its abundance, and its functional relevance in a biological and/or medical context. There are many technical and biological issues that will need to be overcome in order to accomplish the full scale mapping.
authors.affiliation: Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Jangravi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Alikhani
authors.forename: Babak
authors.initials: B
authors.lastname: Arefnezhad
authors.forename: Mehdi
authors.initials: M
authors.lastname: Sharifi Tabar
authors.forename: Sara
authors.initials: S
authors.lastname: Taleahmad
authors.forename: Razieh
authors.initials: R
authors.lastname: Karamzadeh
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Jadaliha
authors.forename: Seyed Ahmad
authors.initials: SA
authors.lastname: Mousavi
authors.forename: Diba
authors.initials: D
authors.lastname: Ahmadi Rastegar
authors.forename: Pouria
authors.initials: P
authors.lastname: Parsamatin
authors.forename: Haghighat
authors.initials: H
authors.lastname: Vakilian
authors.forename: Shahab
authors.initials: S
authors.lastname: Mirshahvaladi
authors.forename: Marjan
authors.initials: M
authors.lastname: Sabbaghian
authors.forename: Anahita
authors.initials: A
authors.lastname: Mohseni Meybodi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mirzaei
authors.forename: Maryam
authors.initials: M
authors.lastname: Shahhoseini
authors.forename: Marzieh
authors.initials: M
authors.lastname: Ebrahimi
authors.forename: Abbas
authors.initials: A
authors.lastname: Piryaei
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Moosavi-Movahedi
authors.forename: Paul A
authors.initials: PA
authors.lastname: Haynes
authors.forename: Ann K
authors.initials: AK
authors.lastname: Goodchild
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Nasr-Esfahani
authors.forename: Esmaiel
authors.initials: E
authors.lastname: Jabbari
authors.forename: Hossein
authors.initials: H
authors.lastname: Baharvand
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sedighi Gilani
authors.forename: Hamid
authors.initials: H
authors.lastname: Gourabi
authors.forename: Ghasem Hosseini
authors.initials: GH
authors.lastname: Salekdeh
mesh_terms: D002874:Chromosome Mapping; D041322:Chromosomes, Human, Y / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D050174:Genetic Diseases, Y-Linked / Q000235:genetics / Q000503:physiopathology; D016045:Human Genome Project; D006801:Humans; D008297:Male; D060066:Protein Interaction Maps; D020543:Proteome / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012727:Sex Characteristics
chemical_list: D020543:Proteome