title: Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth.
abstract: A neurofibromatosis type 1 (NF1)-based bioassay-guided phytochemical investigation on Zanthoxylum armatum collected in Nepal led to the isolation of new timuramides A-D (1-4) and six known sanshools (5-10). The structures of all compounds were established by using modern spectroscopic techniques, including 1D and 2D NMR analysis and comparison with previously reported data. Most of the compounds inhibited growth of an Nf1- and p53-deficient mouse glioma cell line at noncytotoxic concentrations.
authors.affiliation: Molecular Targets Laboratory, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.
authors.forename: Krishna P
authors.initials: KP
authors.lastname: Devkota
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wilson
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Henrich
authors.forename: James B
authors.initials: JB
authors.lastname: McMahon
authors.forename: Karlyne M
authors.initials: KM
authors.lastname: Reilly
authors.forename: John A
authors.initials: JA
authors.lastname: Beutler
mesh_terms: D000818:Animals; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009390:Nepal; D009456:Neurofibromatosis 1 / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D006877:Hydroxamic Acids; D016159:Tumor Suppressor Protein p53