title: Review on the angiotensin-I-converting enzyme (ACE) inhibitor peptides from marine proteins.
abstract: Hypertension is now a major problem threatening people health in the world. Angiotensin-I-converting enzyme (ACE) plays an important physiological role in regulation of blood pressure via conversion of angiotensin I to angiotensin II. Inhibition of ACE may have an antihypertensive effect as a consequence of a decrease in blood pressure. A number of terrestrial-derived peptides have been reviewed about their in vitro and in vivo ACE-inhibitory activities. Marine organisms are potentially an untapped source of drugs and value-added food production. The aim of this review is to discuss the marine-derived ACE-inhibitory peptides from sources, production, structure aspects, and their future prospects as functional food or novel therapeutic drug candidates.
authors.affiliation: School of Biological Science and Technology, Central South University, Changsha 410013, China. helenhe@csu.edu.cn
authors.forename: Hai-Lun
authors.initials: HL
authors.lastname: He
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Chang-Bei
authors.initials: CB
authors.lastname: Ma
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D010455:Peptides