title: Clinical features and course of bacterial meningitis in children.
abstract: OBJECTIVE
  To analyze the clinical features and course of and to define the risk factors for bacterial meningitis in children.
  
  
  METHODS
  Retrospective study of 100 cases of bacterial meningitis in patients aged 0-18 years admitted to the Iasi Infectious Diseases Hospital between 2005 and 2010.
  
  
  RESULTS
  We found a clear prevalence in male children (58%) from rural area (67%), with the highest incidence in the age group 2-5 years. A significant percentage of patients (43%) had previous hospitalization, condition which is known as predisposing factor for bacterial meningitis, the most common being ear infections (20%) and height and weight deficit (9%). 71% of patients were admitted within the first 48 h. The most common onset clinical manifestations were fever (84%), vomiting (70%), signs of meningeal irritation (59%), somnolence (23%), loss of appetite (19%), and coma in 5% of patients. In 36% of cases CSF was opalescent with moderate pleocytosis (35%); in 29% of patients CSF albumin level ranged between 0.7-1.0 g, the majority presenting normal glycorahia (71%). In only 21% of cases the microbial agent was identified (pneumococcal and meningococcal etiology, 8% and 6%, respectively). The course was generally favorable, and mortality rate was low (5%). Complications occurred in 3% of patients consisting in hydrocephalus and brain abscess.
  
  
  CONCLUSIONS
  Bacterial meningitis remains a disease with potentially severe course. Clinical onset, most commonly atypical in children, requires differential diagnosis at the time of admission in order to initiate the most appropriate antibiotic therapy.
authors.affiliation: University of Medicine and Pharmacy Grigore T. Popa-Iaşi School of Medicine.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Juganariu
authors.forename: Egidia
authors.initials: E
authors.lastname: Miftode
authors.forename: Danuţ
authors.initials: D
authors.lastname: Teodor
authors.forename: Daniela
authors.initials: D
authors.lastname: Leca
authors.forename: Carmen-Mihaela
authors.initials: CM
authors.lastname: Dorobăţ
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D000855:Anorexia / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D003128:Coma / Q000382:microbiology; D004427:Ear Diseases / Q000453:epidemiology; D005260:Female; D005334:Fever / Q000382:microbiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D044342:Malnutrition / Q000453:epidemiology; D008580:Meningism / Q000382:microbiology; D016920:Meningitis, Bacterial / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D011203:Poverty; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D017678:Sex Distribution; D015996:Survival Rate; D014839:Vomiting / Q000382:microbiology