title: Peripheral neuropathy defined by monofilament insensitivity and diabetes status: NHANES 1999-2004.
abstract: OBJECTIVE
  To determine whether diabetes status, including prediabetes, is associated with increased risk of peripheral neuropathy as defined by monofilament insensitivity.
  
  
  METHODS
  This study used data from the 1999-2004 National Health and Nutrition Examination Survey (n = 7,818). Peripheral neuropathy was defined as one or more insensate sites detected by a Semmes-Weinstein 10-g monofilament. Generalized linear models were used to directly estimate relative risks (RRs) for the association of diabetes status and peripheral neuropathy.
  
  
  RESULTS
  After adjustment compared with no diabetes, prediabetes [RR 1.11 (95% CI 0.92-1.34)] and undiagnosed diabetes [1.08 (0.73-1.61)] were associated with modest increases in risk of peripheral neuropathy, and diabetes was associated with a 74% higher risk of peripheral neuropathy [1.74 (1.50-2.01)].
  
  
  CONCLUSIONS
  Diabetes is associated with increased risk of peripheral neuropathy defined by monofilament insensitivity, but prediabetes and undiagnosed diabetes may be associated with only a modest increase in risk.
authors.affiliation: Health Services Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA. jkaton@uw.edu
authors.forename: Jodie G
authors.initials: JG
authors.lastname: Katon
authors.forename: Gayle E
authors.initials: GE
authors.lastname: Reiber
authors.forename: Karin M
authors.initials: KM
authors.lastname: Nelson
mesh_terms: D003625:Data Collection; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D009749:Nutrition Surveys; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D011236:Prediabetic State / Q000150:complications / Q000453:epidemiology
chemical_list: D006442:Glycated Hemoglobin