title: Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects.
abstract: This randomized, double blind, placebo-controlled, 8 week trial assessed the efficacy on metabolic changes produced by a consumption of a combination of bioactive food ingredients (epigallocatechin gallate, capsaicins, piperine and L-carnitine) versus a placebo, as part of a therapeutic 'lifestyle change' diet, in 86 overweight subjects. Forty-one patients (2/14 F/M; age 43.7 ± 8.5; BMI 30.3 ± 3.5 kg/m(2)) were randomized to the supplemented group and 45 (29/16; age 40.7 ± 10.2; BMI 30.0 ± 2.7) to the control group. We observed that consumption of the dietary supplement was associated with a significantly greater decrease in insulin resistance, assessed by homostasis model assessment (p < 0.001), leptin/adiponectin ratio (p < 0.04), respiratory quotient (p < 0.008). LDL-cholesterol levels (p < 0.01). Moreover, statistically significant differences were recorded between the two groups in relation to urinary norepinephrine levels (p < 0.001). Leptin, ghrelin, C-reactive protein decreased and resting energy expenditure increased significantly in the supplemented group (p < 0.05, 0.03, 0.02 and 0,02 respectively), but not in the placebo group; adiponectin decreased significantly in the placebo group (0.001) but not in the supplemented group, although no statistical significance between the groups was elicited. BMI, fat mass (assessed by DXA) and vascular endothelial growth factor significantly decreased, whilst the resting energy expenditure/free fat mass significantly increased in both groups. In general, a greater change was recorded in the supplemented group compared to the placebo, although no statistically significant difference between the two groups was recorded. These results suggest that the combination of bioactive food ingredients studied might be useful for the treatment of obesity-related inflammatory metabolic dysfunctions.
authors.affiliation: Department of Applied Health Sciences, Section of Human Nutrition and Dietetics, Faculty of Medicine, University of Pavia, Azienda di Servizi alla Persona di Pavia, Servizio Endocrino Nutrizionale, Istituto di Riabilitazione "Santa Margherita", Via Emilia 12, Pavia, Italy, mariangela.rondanelli@unipv.it.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Rondanelli
authors.forename: Annalisa
authors.initials: A
authors.lastname: Opizzi
authors.forename: Simone
authors.initials: S
authors.lastname: Perna
authors.forename: Milena
authors.initials: M
authors.lastname: Faliva
authors.forename: Sebastiano Bruno
authors.initials: SB
authors.lastname: Solerte
authors.forename: Marisa
authors.initials: M
authors.lastname: Fioravanti
authors.forename: Catherine
authors.initials: C
authors.lastname: Klersy
authors.forename: Edda
authors.initials: E
authors.lastname: Cava
authors.forename: Cava
authors.initials: C
authors.lastname: Edda
authors.forename: Maddalena
authors.initials: M
authors.lastname: Paolini
authors.forename: Paolini
authors.initials: P
authors.lastname: Maddalena
authors.forename: Luciano
authors.initials: L
authors.lastname: Scavone
authors.forename: Scavone
authors.initials: S
authors.lastname: Luciano
authors.forename: Paola
authors.initials: P
authors.lastname: Ceccarelli
authors.forename: Ceccarelli
authors.initials: C
authors.lastname: Paola
authors.forename: Emanuela
authors.initials: E
authors.lastname: Castellaneta
authors.forename: Castellaneta
authors.initials: C
authors.lastname: Emanuela
authors.forename: Claudia
authors.initials: C
authors.lastname: Savina
authors.forename: Savina
authors.initials: S
authors.lastname: Claudia
authors.forename: Lorenzo Maria
authors.initials: LM
authors.lastname: Donini
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000470:Alkaloids / Q000008:administration & dosage; D052117:Benzodioxoles / Q000008:administration & dosage; D002211:Capsaicin / Q000008:administration & dosage; D002331:Carnitine / Q000008:administration & dosage; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004038:Diet, Reducing; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000178:diet therapy* / Q000378:metabolism; D010880:Piperidines / Q000008:administration & dosage; D053284:Polyunsaturated Alkamides / Q000008:administration & dosage; D013997:Time Factors; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult
chemical_list: D054392:Adipokines; D000470:Alkaloids; D052117:Benzodioxoles; D018836:Inflammation Mediators; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D002392:Catechin; C045651:epigallocatechin gallate; D002211:Capsaicin; D002331:Carnitine; C008922:piperine