title: Antigen presentation by Langerhans cells.
abstract: Langerhans cells and other skin-resident dendritic cells (DC) are required for the development of cutaneous adaptive immune responses. In vivo experiments using mice with selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that each subset makes a unique contribution to the adaptive response. This review focuses on the functional outcome of antigen presentation by Langerhans cells. Special attention is given to their ability to promote CD4 T cell differentiation in a variety of inflammatory contexts and whether this subset has the capacity to cross-prime CD8 T cells.
authors.affiliation: Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN, United States. botond@umn.edu
authors.forename: Botond Z
authors.initials: BZ
authors.lastname: Igyártó
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Kaplan
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D030801:Animals, Genetically Modified; D017951:Antigen Presentation; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D060833:Cellular Microenvironment; D054884:Host-Pathogen Interactions; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology; D007801:Langerhans Cells / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D012867:Skin / Q000276:immunology*
chemical_list: D020381:Interleukin-17