title: Effect of various classes of pesticides on expression of stress genes in transgenic C. elegans model of Parkinson's disease.
abstract: Neurodegenerative diseases are known to be associated with genetic and environmental factors. The multifactorial Parkinson's disease (PD) is triggered and/or further worsened by exposure to certain pesticides. Existing literature suggests a link between pesticide exposure and increased incidence of PD. We carried out the present study to look into the stress gene expression pattern of transgenic Caenorhabditis elegans (C. elegans) model of PD after exposure to pesticides from different classes. Expression level of sod-1, sod-2, sod-3, hsp-70, hsp-60, and hsp-16.2 stress responsive genes was determined using qPCR. Our findings demonstrate that the expression of stress related genes does not follow a generalized pattern to different toxicants; rather each pesticide class has a specific expression signature.
authors.affiliation: Laboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology, CSIRCentral Drug Research Institute, Lucknow, 226 001, UP, India.
authors.forename: Pooja
authors.initials: P
authors.lastname: Jadiya
authors.forename: Snober S
authors.initials: SS
authors.lastname: Mir
authors.forename: Aamir
authors.initials: A
authors.lastname: Nazir
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000096:biosynthesis* / Q000235:genetics; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism*; D010575:Pesticides / Q000145:classification / Q000633:toxicity*
chemical_list: D029742:Caenorhabditis elegans Proteins; D010575:Pesticides