title: Efficacy and safety of low-dose peginterferon alpha-2a plus ribavirin on chronic hepatitis C.
abstract: Background. The purpose of this study was to assess the efficacy and safety of low-dose peg-IFN α-2a plus ribavirin on the treatment of patients with chronic hepatitis C virus (HCV) infection. Patients and Methods. A total of 243 HCV patients treated with different doses of peg-IFN α-2a plus ribavirin were stratified into three groups. End-of-treatment response (ETR) and sustained viral response (SVR) were evaluated for efficacy. Adverse events and laboratory abnormalities were conducted for safety. Results. ETR and SVR in group I were obtained in 83.9% and 68.9% of the patients, separately, which was similar to groups II (84.1% and 68.3%) and III (81.7% and 66.7%). The received peg-IFN α-2a dose was not the independent factor-related SVR in our population (OR, 1.31; 95% CI, 0.94-1.81; P = 0.106). The frequency of no adverse events reported in group III (24.7%) was significantly higher than that in group I (11.5%) and group II (12.7%) (P = 0.036). Conclusions. The peg-IFN α-2a 90 μg/week plus ribavirin is as effective as, and better tolerated than, peg-IFN α-2a standard dose with ribavirin in the treatment of chronic hepatitis C. This low-dose combination achieves high SVR rates and may be cost-saving.
authors.affiliation: Institute of Infectious Diseases, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China.
authors.forename: Zehui
authors.initials: Z
authors.lastname: Yan
authors.forename: Ke
authors.initials: K
authors.lastname: Fan
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Mao
authors.forename: Guohong
authors.initials: G
authors.lastname: Deng
authors.forename: Yuming
authors.initials: Y
authors.lastname: Wang