title: Comparison of standardized uptake values obtained from two- and three-dimensional modes of fluorine-18 fluorodeoxyglucose PET-CT in oncological cases.
abstract: OBJECTIVE
  We investigated the usability of standardized uptake values (SUV) obtained from both two- and three-dimensional (2D and 3D) positron-emission tomography and computed tomography (PET-CT) imaging, and compared the images obtained from these techniques in terms of image quality, lesion detectability, and the presence of artifacts.
  
  
  METHODS
  Image data from 100 patients, who had undergone two PET imagings obtained in 2D and 3D mode after a low dose CT, were evaluated prospectively. Subjective analysis of 2D and 3D images was performed by two readers evaluating the following criteria: overall image quality, detectability of each identified lesion, and the presence of artifacts. The lesions recognized by the readers were also analyzed quantitatively by measuring SUV values.
  
  
  RESULTS
  There was a significant difference between the SUVs obtained in 2D and 3D modes. Regardless if the first scan was performed in 2D or 3D mode, the values obtained from 3D imaging were significantly lower than those obtained from 2D imaging (mean SUV(max) was 10.48±7.57 for 2D, and 9.66±6.93 for 3D, P < 0.001). Visual analysis did not reveal significant differences regarding lesion detectability between two modes.
  
  
  CONCLUSIONS
  In oncological PET-CT applications, SUV values are significantly lower in 3D compared with 2D mode. Thus when serial scanning is needed to evaluate response to therapy in the same patient, the imaging modality should be taken into account and performed with the same method to avoid misinterpretation. Additionally, 3D PET-CT imaging can be used instead of 2D PET-CT due to its shorter scanning time without loss of lesion detectability.
authors.affiliation: Clinic of of Nuclear Medicine, Hatay Antakya State Hospital, Hatay, Turkey. beyzakocabas2002@yahoo.com
authors.forename: Beyza
authors.initials: B
authors.lastname: Kocabaş
authors.forename: Ali Fuat
authors.initials: AF
authors.lastname: Yapar
authors.forename: Mehmet
authors.initials: M
authors.lastname: Reyhan
authors.forename: Ayşe
authors.initials: A
authors.lastname: Aktaş
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aydin
authors.forename: Esra Arzu
authors.initials: EA
authors.lastname: Gençoğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D002648:Child; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis*; D015588:Observer Variation; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18