title: Assessment of the antineoplastic potential of chalcones in animal models.
abstract: One part of chemical space that is endowed with interesting biological properties is the area of the chalcones. With this review, we provide a comprehensive overview of the numerous in vivo animal studies on the antineoplastic potential of both natural and synthetic members of this flavonoid subclass (covering: up to mid-2011). The thus far identified modes of action of these compounds are also discussed. We hope that this overview may stimulate deeper investigations into the biochemical mechanisms by which chalcones exert their antineoplastic action. As a result, in the foreseeable future, chalcones may prove suitable lead molecules or early drug candidates for the prevention or treatment of various neoplastic diseases.
authors.affiliation: Research Group SynBioC, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
authors.forename: B I
authors.initials: BI
authors.lastname: Roman
authors.forename: T S A
authors.initials: TS
authors.lastname: Heugebaert
authors.forename: M E
authors.initials: ME
authors.lastname: Bracke
authors.forename: C V
authors.initials: CV
authors.lastname: Stevens
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006569:Hesperidin / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D047188:Chalcones; C035032:sofalcone; C033022:hesperidin methylchalcone; D006569:Hesperidin