title: Preliminary study of the distribution and accumulation of GSH/Cys metabolites of hepatotoxic microcystins-RR in common carp from a lake with protracted cyanobacterial bloom (Lake Taihu, China).
abstract: Tissue distributions and seasonal dynamics of glutathione and cysteine S-conjugates of microcystin-RR in feral fish from Lake Taihu were studied. High MC-RR-Cys was found in tissues, Mean MC-RR-Cys in kidney (0.253 μg g(-1) DW) was 4 times of that in liver (0.063 μg g(-1) DW). Ratios of MC-RR-Cys/MC-RR in liver/kidney reached as high as 5.3/39.8, respectively, meanwhile, kidney showed low accumulation of MC-RR and higher formation efficiency of MC-RR-Cys than liver (7.51× to liver), this suggested that MC-RR-Cys were significantly accumulated with the depletion of MC-RR, and it was selectively biotransformed to MC-RR-Cys in kidney for further excretion.
authors.affiliation: Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7th, Wuhan, 430072, People's Republic of China.
authors.forename: Laiyan
authors.initials: L
authors.lastname: Wu
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Tao
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Zhimei
authors.initials: Z
authors.lastname: Ma
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
mesh_terms: D000818:Animals; D002347:Carps / Q000378:metabolism*; D002681:China; D000458:Cyanobacteria / Q000254:growth & development*; D003545:Cysteine / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods; D005978:Glutathione / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D060106:Lakes / Q000737:chemistry / Q000382:microbiology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008387:Marine Toxins; D052998:Microcystins / Q000378:metabolism / Q000493:pharmacokinetics* / Q000633:toxicity; D012621:Seasons; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D008387:Marine Toxins; D052998:Microcystins; D014874:Water Pollutants, Chemical; C063855:microcystin RR; D005978:Glutathione; D003545:Cysteine