title: [Palliative radiation therapy for opioid-resistant pain caused by metastatic pancreatic cancer with bone metastasis-a case report].
abstract: OBJECTIVE
  Herein, we report a case in which intractable pain caused by pancreatic cancer with bone metastasis was improved by palliative radiation therapy.
  
  
  METHODS
  A 63-year-old woman was diagnosed with advanced pancreatic cancer with liver and lung metastasis and received systemic chemotherapy of S-1 combined with gemcitabine. Two months after the start of chemotherapy, the patient developed bone metastasis at the 7th cervical vertebra with severe right hand pain. Even after receiving combined modality therapy for the pain caused by bone metastasis, including administration of oxycodone, she continued to experience pain due to the bone metastasis. However, the pain improved considerably after palliative radiation therapy at a dose of 37.5 Gy/15 Fr. The patient remains free of pain due to bone metastasis 5 months after the palliative radiation therapy.
  
  
  CONCLUSIONS
  We believe that palliative radiation therapy still plays an important role in the improvement of opioid-resistant intractable pain caused by bone metastasis.
authors.affiliation: Dept. of Surgery, Kyoundo Hospital, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kawamoto
authors.forename: Seiki
authors.initials: S
authors.lastname: Miura
authors.forename: Tadaomi
authors.initials: T
authors.lastname: Fukada
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000701:Analgesics, Opioid / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy*; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000473:pathology*
chemical_list: D000701:Analgesics, Opioid