title: HLA-B27 and clinical features of acute anterior uveitis in Cuba.
abstract: BACKGROUND
  There are few data about the epidemiology of acute anterior uveitis (AAU) from Latin America. In Cuba, the genetic admixture of the population could modify the HLA-B27-AAU association. In this study, the authors compared the distribution of the HLA-B27 allele in patients and controls and described some clinical outcomes.
  
  
  METHODS
  The clinical features of patients were collected from their medical records. HLA-B27 genotyping was performed using the polymerase chain reaction. HLA-B27 allele distribution was compared between patients and controls.
  
  
  RESULTS
  HLA-B27 allele was present in 55.4% of the patients and 0.87% of the controls. AAU HLA-B27 positivity was associated with males, frequent episodes, and a systemic disease. There is no difference in ocular complications between HLA-B27-positive and -negative patients.
  
  
  CONCLUSIONS
  Results from this study are similar to data described in other countries. HLA-B27 allele distribution in controls is lower than other reports in Caucasian populations.
authors.affiliation: Department of Molecular Genetics, Hermanos Ameijeiras Hospital, Havana, Cuba.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Torres
authors.forename: Sandra
authors.initials: S
authors.lastname: Borges
authors.forename: Adriana
authors.initials: A
authors.lastname: Artiles
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000483:Alleles; D003462:Cuba / Q000453:epidemiology; D004247:DNA / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015796:HLA-B27 Antigen / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D014606:Uveitis, Anterior / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology
chemical_list: D015796:HLA-B27 Antigen; D004247:DNA