title: Development of a fluorescent chemosensor for the detection of kynurenine.
abstract: Kynurenine, a metabolite of tryptophan, is known to contribute to cancer progression when overproduced. A method for facile fluorescent sensing of kynurenine using sensor 1 has been developed. When bound at low pH, sensor 1 undergoes a very large bathochromic shift because kynurenine extends the conjugation of the fluorophore. This unusual mechanism of activation provides a 390-fold fluorescence enhancement that is very specific to kynurenine and a wavelength of fluorescence that extends into the red.
authors.affiliation: Department of Chemistry, University of Missouri, Columbia, Missouri 65211, USA.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Klockow
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Glass
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007737:Kynurenine / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D014364:Tryptophan / Q000378:metabolism*
chemical_list: D005456:Fluorescent Dyes; D007737:Kynurenine; D014364:Tryptophan