title: Screening of pharmacologic adulterant classes in herbal formulations using voltammetry of microparticles.
abstract: A solid state electrochemical method for screening different families of adulterant chemicals illegally added to commercial phytotherapuetic formulations is described. The proposed method, based on the voltammetry of microparticles approach, permits a fast and sensitive way to distinguish between anorexics (amfepramone, fenproporex, sibutramine), benzozodiazepinic anxiolytics (clonazepam, flurazepam, alprazolam, midazolam, medazepam, chlordiazepoxide, diazepam), antidepressants (bupropione, fluoxetine, sertraline, paroxetine), diuretics (hydrochlorothiazide, furosemide, chlortalidone, amiloride, spironolactone), and hypoglycemics (glimepiride, chlorpropamide, glibenclamide) based on characteristic voltammetric signals recorded on solid micro- or nanosamples attached to graphite electrodes immersed into aqueous electrolytes.
authors.affiliation: Departament de Química Analítica, Universitat de València, Dr. Moliner, 50, 46100 Burjassot (València), Spain. antonio.domenech@uv.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Doménech-Carbó
authors.forename: Mariele
authors.initials: M
authors.lastname: Martini
authors.forename: Leandro Machado
authors.initials: LM
authors.lastname: de Carvalho
authors.forename: Carine
authors.initials: C
authors.lastname: Viana
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Doménech-Carbó
authors.forename: Miguel
authors.initials: M
authors.lastname: Silva
mesh_terms: D002626:Chemistry, Pharmaceutical; D004340:Drug Contamination; D004353:Drug Evaluation, Preclinical / Q000379:methods; D055664:Electrochemical Techniques; D008863:Microspheres; D028321:Plant Preparations / Q000032:analysis* / Q000737:chemistry
chemical_list: D028321:Plant Preparations