title: Minor fluctuations in renal function may alter therapeutic drug concentrations substantially during high-dose, continuous-infusion beta-lactam therapy for multi-drug-resistant Gram-negative bacilli.
authors.forename: Cheguevara I
authors.initials: CI
authors.lastname: Afaneh
authors.forename: Vanessa P
authors.initials: VP
authors.lastname: Ho
authors.forename: Peter
authors.initials: P
authors.lastname: McWhorter
authors.forename: David P
authors.initials: DP
authors.lastname: Nicolau
authors.forename: Philip S
authors.initials: PS
authors.lastname: Barie
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood*; D016903:Drug Monitoring; D024901:Drug Resistance, Multiple, Bacterial; D005919:Glomerular Filtration Rate; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007677:Kidney Function Tests; D008297:Male; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000008:administration & dosage* / Q000097:blood*
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D000077731:Meropenem