title: Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model.
abstract: In the present study, the attenuation of type ІІ diabetes by dieckol, a phlorotannin derivative isolated from brown seaweed, Ecklonia cava was investigated in C57BL/KsJ-db/db, a type ІІ diabetes mouse model. Dieckol was administered intraperitoneal injection at doses of 10 and 20 mg/kg body weight diabetes mice for 14 days. The blood glucose level, serum insulin level and body weight were significantly reduced in the dieckol administered group, compared to that of the saline administered group. Furthermore, reduced thiobarbituric acid reactive substraces (TBARS), as well as increased activities of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-px) in liver tissues were observed in the dieckol administered group. In addition, increased levels of the phosphorylation of AMPK and Akt were observed in the muscle tissues of the dieckol administered group in a Western blotting analysis. According to the findings of this study, it could be suggested that, dieckol can be developed as a therapeutic agent for type ІІ diabetes.
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Min-Cheol
authors.initials: MC
authors.lastname: Kang
authors.forename: W A J P
authors.initials: WA
authors.lastname: Wijesinghe
authors.forename: Seung-Hong
authors.initials: SH
authors.lastname: Lee
authors.forename: Sung-Myung
authors.initials: SM
authors.lastname: Kang
authors.forename: Seok-Chun
authors.initials: SC
authors.lastname: Ko
authors.forename: Xiudong
authors.initials: X
authors.lastname: Yang
authors.forename: Nalae
authors.initials: N
authors.lastname: Kang
authors.forename: Byong-Tae
authors.initials: BT
authors.lastname: Jeon
authors.forename: Jaell
authors.initials: J
authors.lastname: Kim
authors.forename: Dae-Ho
authors.initials: DH
authors.lastname: Lee
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage* / Q000302:isolation & purification; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004195:Disease Models, Animal; D005979:Glutathione Peroxidase / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D007328:Insulin / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D000459:Phaeophyceae / Q000737:chemistry*; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D012624:Seaweed / Q000737:chemistry*; D015398:Signal Transduction; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D001572:Benzofurans; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; C503840:dieckol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D051057:Proto-Oncogene Proteins c-akt; D055372:AMP-Activated Protein Kinases