title: A child with three episodes of reversible splenial lesion.
abstract: In this study, we report the case of an 8-year-old girl who had three episodes of reversible splenial lesion of the corpus callosum (SCC) in 2 years. Vomiting, hypoglycemia, and fever were followed by altered consciousness and diminished muscle tone. In each episode, the clinical manifestations and abnormalities detected during magnetic resonance imaging resolved in 2 weeks. Transient alteration of vision and spike discharges revealed by interictal electroencephalogram implied the SCC lesions were related to epileptic activities. At follow-up, the patient had not presented with SCC lesions or altered consciousness for more than 4 years after undergoing carbamazepine treatment. Our case is the first report of a patient who presented with three episodes of reversible splenial lesion.
authors.affiliation: Division of Neurology, Kanagawa Children's Medical Center, Yokohama, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kouga
authors.forename: Mizue
authors.initials: M
authors.lastname: Iai
authors.forename: Sumimasa
authors.initials: S
authors.lastname: Yamashita
authors.forename: Noriko
authors.initials: N
authors.lastname: Aida
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Takanashi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Osaka
mesh_terms: D001927:Brain Diseases / Q000150:complications / Q000473:pathology*; D002648:Child; D003244:Consciousness Disorders / Q000209:etiology; D003337:Corpus Callosum / Q000473:pathology*; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D008279:Magnetic Resonance Imaging