title: Genistein and daidzein: different molecular effects on prostate cancer.
abstract: Diet is believed to play an important role in cancer. It has been revealed by epidemiological studies that Asian populations, who consume phytoestrogens in large amounts, have a lower incidence of prostate cancer in comparison with the Western world, where consumption of soy is lower. Genistein and daidzein, the soy phytoestrogens most widely studied, are believed to be potent anticancer agents and have been shown to possess anticancer properties. It has been shown that these compounds inhibit the growth of cancer cells through the modulation of genes controlling cell-cycle progression. Genistein inhibits the activation of the kappa light polypeptide gene enhancer in B-cells (NF-κB), signaling pathway, which is implicated in the balance between cell survival and programmed cell death (apoptosis). Antioxidant and antiangiogenesis properties of genistein have been also described. Soy isoflavones are also implicated in reversion of epigenetic events observed in prostate cancer. Significant advances have been made for understanding how soy isoflavones are implicated in protection against prostate cancer. However, more studies are needed to better-understand and elucidate all pathways mobilized by genistein and daidzein, in order to fully exploit their anticancer properties.
authors.affiliation: Department of Oncogenetics, Jean Perrin Center, 58 rue Montalembert, 63000 Clermont-Ferrand Cedex 01, France. Yves-Jean.BIGNON@cjp.fr
authors.forename: Mawussi
authors.initials: M
authors.lastname: Adjakly
authors.forename: Marjolaine
authors.initials: M
authors.lastname: Ngollo
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Boiteux
authors.forename: Yves-Jean
authors.initials: YJ
authors.lastname: Bignon
authors.forename: Laurent
authors.initials: L
authors.lastname: Guy
authors.forename: Dominique
authors.initials: D
authors.lastname: Bernard-Gallon
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D057890:Epigenomics; D005247:Feeding Behavior; D019833:Genistein / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D048789:Phytoestrogens / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000178:diet therapy / Q000453:epidemiology; D013025:Glycine max / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D007529:Isoflavones; D016328:NF-kappa B; D048789:Phytoestrogens; C004742:daidzein; D019833:Genistein