title: Children's Oncology Group's 2013 blueprint for research: acute myeloid leukemia.
abstract: For the 365 children diagnosed with acute myeloid leukemia in the US annually, 5-year survival for patients on COG trials with low, intermediate, and high risk disease is 83%, 62%, and 23%, respectively. Recent advances include improved therapeutic stratification, improved survival with dose intensification, and further elucidation of the heterogeneity specific to childhood AML. These discoveries now guide current strategy incorporating targeted agents to pathways specific to childhood AML as well as evaluating methods to increase the sensitivity of the leukemic stem cell, first in Phase II feasibility trials followed by Phase III efficacy trials of the most promising agents. Acute myeloid leukemia in children, though with similar subgroups to adults, remains uniquely different based upon quite different prevalence of subtypes as well as overall response to therapy. The Children's Oncology Group's research agenda builds upon earlier efforts to better elucidate the leukemogenic steps distinct to childhood AML in order to more scientifically develop and test novel therapeutic approaches to the treatment and ultimate cure for children with this disorder. Pediatr Blood Cancer 2013; 60: 964-971. © 2012 Wiley Periodicals, Inc.
authors.affiliation: Children's Mercy Hospitals & Clinics, Kansas City, MO 64108, USA. agamis@cmh.edu
authors.forename: Alan S
authors.initials: AS
authors.lastname: Gamis
authors.forename: Todd A
authors.initials: TA
authors.lastname: Alonzo
authors.forename: John P
authors.initials: JP
authors.lastname: Perentesis
authors.forename: Soheil
authors.initials: S
authors.lastname: Meshinchi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D012106:Research
chemical_list: D000970:Antineoplastic Agents