title: Association between the single-nucleotide polymorphism rs12425791 and ischemic stroke in Chinese populations: new data and meta-analysis.
abstract: BACKGROUND
  Two single-nucleotide polymorphisms rs11833579 and rs12425791 located on chromosome 12p13 were reported to be associated with ischemic stroke in Caucasians. In the present study, we investigated whether the single-nucleotide polymorphism rs12425791 was associated with ischemic stroke in Chinese populations.
  
  
  METHODS
  We carried out a case-control study examining a total of 166 Guangxi Han patients with ischemic stroke and 192 healthy controls. We also performed a meta-analysis of the data from our study and those from published studies to investigate whether an association between rs12425791 and ischemic stroke could be detected in Chinese populations.
  
  
  RESULTS
  There was no statistically significant association between the single-nucleotide polymorphism rs12425791 and ischemic stroke in the Guangxi Han population. Our meta-analysis also found no significant association between rs12425791 and ischemic stroke in Chinese populations [allelic model odds ratio (OR) = 1.01, 95% confidence interval (CI), 0.96-1.07; dominant model OR = 1.01, 95%CI, 0.94-1.10; recessive model OR = 1.00, 95%CI, 0.86-1.17].
  
  
  CONCLUSIONS
  The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in Chinese populations.
authors.affiliation: Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Gu
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Xie
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Guangliang
authors.initials: G
authors.lastname: Wu
authors.forename: Jinjing
authors.initials: J
authors.lastname: Tan
authors.forename: Baoyun
authors.initials: B
authors.lastname: Liang
authors.forename: Weihua
authors.initials: W
authors.lastname: Dou
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
authors.forename: Jinping
authors.initials: J
authors.lastname: Wang
authors.forename: Nong
authors.initials: N
authors.lastname: Tang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002545:Brain Ischemia / Q000150:complications / Q000235:genetics*; D016022:Case-Control Studies; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020521:Stroke / Q000150:complications / Q000235:genetics*