title: [Long-term remission of Langerhans cell sarcoma by AIM regimen combined with involved-field irradiation].
abstract: A 67-year-old woman presented with a right inguinal mass in May 2006. CT scan showed lymph node involvement from the right inguinal to the common iliac and (18)F-FDG-PET revealed uptake in those areas. Biopsy results indicated Langerhans cell sarcoma (LCS). Interestingly, tumor cells expressed a high MIB1 index of 30%. We administered doxorubicin, ifosfamide, and mesna (AIM) chemotherapy, which were reported to effectively treat soft tissue sarcoma. After 5 courses of AIM therapy and involved-field radiation for residual diseases and a relapsed lesion on her right cervical node, she has remained in complete remission for more than 4 years. LCS is an intractable malignant disease and the optimal therapeutic strategy remains unclear. The AIM regimen combined with radiation therapy may be an effective treatment option for this disease.
authors.affiliation: Department of Hematology, Nagano Red Cross Hospital, Japan.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Shimizu
authors.forename: Wataru
authors.initials: W
authors.lastname: Takeda
authors.forename: Takehiko
authors.initials: T
authors.lastname: Kirihara
authors.forename: Keijiro
authors.initials: K
authors.lastname: Sato
authors.forename: Yuko
authors.initials: Y
authors.lastname: Fujikawa
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Ueki
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sumi
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ueno
authors.forename: Naoaki
authors.initials: N
authors.lastname: Ichikawa
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Masahide
authors.initials: M
authors.lastname: Watanabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Uehara
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D054752:Langerhans Cell Sarcoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D015080:Mesna / Q000008:administration & dosage; D011854:Radiochemistry; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004317:Doxorubicin; D015080:Mesna; D007069:Ifosfamide