title: The 2011-12 pilot European Sentinel Registry of Transcatheter Aortic Valve Implantation: in-hospital results in 4,571 patients.
abstract: OBJECTIVE
  The aim of this prospective multinational registry is to assess and identify predictors of in-hospital outcome and complications of contemporary TAVI practice.
  
  
  RESULTS
  The Transcatheter Valve Treatment Sentinel Pilot Registry is a prospective independent consecutive collection of individual patient data entered into a web-based case record form (CRF) or transferred from compatible national registries. A total of 4,571 patients underwent TAVI between January 2011 and May 2012 in 137 centres of 10 European countries. Average age was 81.4±7.1 years with equal representation of the two sexes. Logistic EuroSCORE (20.2±13.3), access site (femoral approach: 74.2%), type of anaesthesia and duration of hospital stay (9.3±8.1 days) showed wide variations among the participating countries. In-hospital mortality (7.4%), stroke (1.8%), myocardial infarction (0.9%), major vascular complications (3.1%) were similar in the SAPIEN XT and CoreValve (p=0.15). Mortality was lower in transfemoral (5.9%) than in transapical (12.8%) and other access routes (9.7%; p<0.01). Advanced age, high logistic EuroSCORE, pre-procedural ≥grade 2 mitral regurgitation and deployment failure predicted higher mortality at multivariate analysis.
  
  
  CONCLUSIONS
  Increased operator experience and the refinement of valve types and delivery catheters may explain the lower rate of mortality, stroke and vascular complications than in historical studies and registries.
authors.affiliation: Royal Brompton Hospital, London, United Kingdom. c.dimario@rbht.nhs.uk
authors.forename: Carlo
authors.initials: C
authors.lastname: Di Mario
authors.forename: Helene
authors.initials: H
authors.lastname: Eltchaninoff
authors.forename: Neil
authors.initials: N
authors.lastname: Moat
authors.forename: Javier
authors.initials: J
authors.lastname: Goicolea
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Ussia
authors.forename: Petr
authors.initials: P
authors.lastname: Kala
authors.forename: Peter
authors.initials: P
authors.lastname: Wenaweser
authors.forename: Marian
authors.initials: M
authors.lastname: Zembala
authors.forename: Georg
authors.initials: G
authors.lastname: Nickenig
authors.forename: Eduardo
authors.initials: E
authors.lastname: Alegria Barrero
authors.forename: Thomas
authors.initials: T
authors.lastname: Snow
authors.forename: Bernard
authors.initials: B
authors.lastname: Iung
authors.forename: Pepe
authors.initials: P
authors.lastname: Zamorano
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schuler
authors.forename: Roberto
authors.initials: R
authors.lastname: Corti
authors.forename: Ottavio
authors.initials: O
authors.lastname: Alfieri
authors.forename: Bernard
authors.initials: B
authors.lastname: Prendergast
authors.forename: Peter
authors.initials: P
authors.lastname: Ludman
authors.forename: Stephan
authors.initials: S
authors.lastname: Windecker
authors.forename: Manel
authors.initials: M
authors.lastname: Sabate
authors.forename: Martine
authors.initials: M
authors.lastname: Gilard
authors.forename: Adam
authors.initials: A
authors.lastname: Witowski
authors.forename: Haim
authors.initials: H
authors.lastname: Danenberg
authors.forename: Erwin
authors.initials: E
authors.lastname: Schroeder
authors.forename: Francesco
authors.initials: F
authors.lastname: Romeo
authors.forename: Carlos
authors.initials: C
authors.lastname: Macaya
authors.forename: Genevieve
authors.initials: G
authors.lastname: Derumeaux
authors.forename: Aldo
authors.initials: A
authors.lastname: Maggioni
authors.forename: Luigi
authors.initials: L
authors.lastname: Tavazzi
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods* / Q000401:mortality; D062906:Cardiac Catheters; D016009:Chi-Square Distribution; D002983:Clinical Competence; D015897:Comorbidity; D004867:Equipment Design; D005060:Europe; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods* / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D018579:Patient Selection; D010865:Pilot Projects; D011446:Prospective Studies; D011474:Prosthesis Design; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome