title: [A case of recurrent gastric cancer successfully treated by a combination of CPT-11 and CDDP as the third-line chemotherapy].
abstract: We report a case of recurrent gastric cancer successfully treated by a combination of CPT-11 and CDDP as the third- line chemotherapy. A 78-year-old man with advanced gastric cancer underwent a curative distal gastrectomy. Three years later, the tumor marker level began to rise and computed tomography (CT) revealed lymph node metastasis invading the pancreas resulting in pancreatic duct dilatation. S-1 treatment was initiated but was discontinued because of a systemic exanthem. Paclitaxel was administrated as secondary chemotherapy. But, after 2 courses, a further increase in the tumor marker level and portal vein invasion were observed. Combination therapy of CPT-11 and CDDP was administered as the third-line chemotherapy. After 3 courses, the tumor marker level normalized, tumor size decreased, and the invasion was eliminated. Third-line chemotherapy against recurrent gastric cancer should be considered if patient performance status (PS) is maintained.
authors.affiliation: Dept. of Surgery, Chiba Kaihin Municipal Hospital, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Tonooka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Wakatsuki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kataoka
authors.forename: Kotaro
authors.initials: K
authors.lastname: Miyazawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Oeda
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008207:Lymphatic Metastasis; D008297:Male; D012008:Recurrence; D016879:Salvage Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin