title: Effect of anger on endothelial-derived vasoactive factors in spontaneously hypertensive rats.
abstract: OBJECTIVE
  We tested whether anger affects the balance between endothelium-derived vasodilators and vasoconstrictors in spontaneously hypertensive rats (SHRs).
  
  
  METHODS
  Five endothelium-produced vasoactive factors (nitric oxide, prostacyclin, urotensin, endothelin and thromboxane B2) were measured in an established SHR behavioural model of anger, in "non-angry" SHR rats, and in control Wistar-Kyoto rats.
  
  
  RESULTS
  All angry SHR rats showed the typical angry behaviour and angry SHR rats had significantly higher blood pressure and heart rate than control rats. Angry rats had significantly lower levels of two vasodilators, nitric oxide and prostacyclin, and significantly higher levels of two vasoconstrictors, endothelin and thromboxane B2 than either non-angry SHR or control rats. Levels of a third vasoconstrictor, urotensin, were significantly lower in angry SHR than in non-angry SHR or control rats.
  
  
  CONCLUSIONS
  Our results suggest that anger causes an imbalance of endothelium-produced vasodilating and vasoconstricting substances. This may have implications for the development and/or progression of hypertension.
authors.affiliation: Shandong University School of Medicine, Jinan 250011, Shandong Province, China. xytsdzydfy@126.com
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Xue
authors.forename: Xiu-Feng
authors.initials: XF
authors.lastname: Mei
authors.forename: Wen-Ge
authors.initials: WG
authors.lastname: Su
authors.forename: Yun-Lun
authors.initials: YL
authors.lastname: Li
authors.forename: Xian-Qing
authors.initials: XQ
authors.lastname: Meng
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000786:Anger; D000818:Animals; D001522:Behavior, Animal; D001794:Blood Pressure; D016232:Endothelins / Q000097:blood; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D011464:Epoprostenol / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D051381:Rats; D011918:Rats, Inbred SHR; D013929:Thromboxane B2 / Q000097:blood; D014579:Urotensins / Q000097:blood; D014662:Vasoconstrictor Agents / Q000097:blood*
chemical_list: D016232:Endothelins; D014579:Urotensins; D014662:Vasoconstrictor Agents; D009569:Nitric Oxide; D013929:Thromboxane B2; D011464:Epoprostenol