title: [The comparative evaluation of the diagnostic value of methods of detection of antibodies to citrullinized proteins under rheumatoid arthritis].
abstract: The hyper production of large specter of autoantibodies, primarily rheumatoid factors and antibodies to citrullinized proteins, is a characteristic sign of rheumatoid arthritis. The detection of these antibodies plays an important role in diagnosing the disease, especially on its early stages. The study compared the diagnostic accuracy of different methods of detection of antibodies to citrullinized proteins under rheumatoid arthritis. The examined sample included 144 patients aged 33-58 years with reliable diagnosis of rheumatoid arthritis. The patients with systemic lupus erythematous, osteoarthritis, psoriatic arthritis, OVERLAP syndrome, ankylosing spondylitis and conditionally healthy donors consisted the comparative group. To detect antibodies to citrullinized proteins the methods of enzyme immunoassay, electrochemiluminescence, immunochromatography were applied. The study demonstrated that all the methods of detection of antibodies to citrullinized proteins have adequate diagnostic value to be implemented both in a routine clinical diagnostic practice and on the stage of screening of patients.
authors.forename: A A
authors.initials: AA
authors.lastname: Novikov
authors.forename: M V
authors.initials: MV
authors.lastname: Cherkasova
authors.forename: E N
authors.initials: EN
authors.lastname: Aleksandrova
authors.forename: T V
authors.initials: TV
authors.lastname: Popkova
authors.forename: E L
authors.initials: EL
authors.lastname: Luchikhina
authors.forename: N S
authors.initials: NS
authors.lastname: Rytikova
authors.forename: E L
authors.initials: EL
authors.lastname: Nasonov
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000175:diagnosis*; D001323:Autoantibodies; D002956:Citrulline / Q000737:chemistry / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000737:chemistry / Q000276:immunology / Q000302:isolation & purification; D012217:Rheumatoid Factor / Q000097:blood
chemical_list: D001323:Autoantibodies; D011506:Proteins; D002956:Citrulline; D012217:Rheumatoid Factor