title: In vitro antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans.
abstract: OBJECTIVE
  To determine and compare antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans.
  
  
  METHODS
  Two tissue conditioners Viscogel and GC Soft combined with nystatin, miconazole and fluconazole were tested against Candida albicans using agar core inhibition diameter assay. One-way analysis of variance followed by Tukey's post-hoc test was used to test the intergroup difference. p-value < 0.05 was considered statistically significant.
  
  
  RESULTS
  Maximum inhibition was seen in the fluconazole groups followed by miconazole and the least inhibition was seen in case of nystatin group.
  
  
  CONCLUSIONS
  Tissue conditioners when mixed with antifungal agents showed satisfactory inhibition of Candida albicans.
  
  
  CONCLUSIONS
  Incorporation of antifungal drugs into tissue conditioners shows good inhibition of C. albicans and can be recommended for clinical use.
authors.affiliation: Department of Prosthodontics, ACPM Dental College, Dhule, Maharashtra, India. nbchop@gmail.com
authors.forename: Narendra
authors.initials: N
authors.lastname: Chopde
authors.forename: Amol
authors.initials: A
authors.lastname: Pharande
authors.forename: Mayur N
authors.initials: MN
authors.lastname: Khade
authors.forename: Yogesh R
authors.initials: YR
authors.lastname: Khadtare
authors.forename: Sanket S
authors.initials: SS
authors.lastname: Shah
authors.forename: Abhishek
authors.initials: A
authors.lastname: Apratim
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D015169:Colony Count, Microbial; D003819:Denture Bases; D003822:Denture Liners; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D008768:Methylmethacrylates / Q000737:chemistry; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D009761:Nystatin / Q000494:pharmacology*; D010795:Phthalic Acids / Q000737:chemistry; D014016:Tissue Conditioning, Dental / Q000295:instrumentation*
chemical_list: D000935:Antifungal Agents; D008689:Methacrylates; D008768:Methylmethacrylates; D010795:Phthalic Acids; C073909:GC Soft-Liner; D009761:Nystatin; D008825:Miconazole; D015725:Fluconazole; C009931:poly(ethylmethacrylate)