title: Pharmaceutical and industrial protein engineering: where we are?
abstract: The huge amount of information, the big number of scientists and their efforts, labs, man/hrs, fund, companies all and others factors build the success of the amazing new branch of genetic engineering the 'protein engineering' (PE). It concerns with the modification of protein structure/function(s) or building protein from scratch. The engineered proteins usually have new criteria(s). Engineering proteins can be mediated on the level of genes or proteins. PE fined its way in different important sectors including industrial, pharmaceutical and medicinal ones. Aspects about PE and its applications will be discussed with this review. The concept, tools, and the industrial applications of the protein, engineered proteins and PE will be under focus. In order to get up to date knowledge about the applications of PE in basic protein and molecular biology, several examples are discussed. PE can play a significant role in different industrial and pharmaceutical sectors if used wisely and selectively.
authors.affiliation: Protein Research Department, Genetic Engineering and Biotechnology Research Institute, Mubarak City for Scientific Research and Technology Applications/Microbiology Division, Pharmaceutics Department, College of Pharmacy at King Saud University (KSU) Riyadh, Kingdom of Saudi Arabia. amroamara@web.de
authors.forename: Amro Abd-Al-Fattah
authors.initials: AA
authors.lastname: Amara
mesh_terms: D000818:Animals; D001709:Biotechnology / Q000266:history / Q000639:trends; D030541:Databases, Genetic; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D051188:Knowledge Bases; D016297:Mutagenesis, Site-Directed; D009154:Mutation; D011487:Protein Conformation; D015202:Protein Engineering / Q000266:history / Q000639:trends; D011506:Proteins / Q000009:adverse effects / Q000737:chemistry / Q000235:genetics / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000266:history / Q000639:trends
chemical_list: D011506:Proteins; D011994:Recombinant Proteins