title: A new synthesis pathway for colloidal silica spheres coated with crystalline titanium oxide and its comparative cyto- and genotoxic study with titanium oxide nanoparticles in rat osteosarcoma (UMR106) cells.
abstract: Spherical particles with an amorphous core of silica and a crystalline shell of titanium oxide (SiO(2)@TiO(2)) formed in a three-step procedure, being the last step a mild chemical treatment. SiO(2)@TiO(2) had a shell with pores (micro and mesopores) permeating between TiO(2) nanocrystals (anatase) and a solid core of amorphous silica. The spheres had an outstanding specific surface area (300 m(2) g(-1)). A cyto- and genotoxic study of SiO(2)@TiO(2) and titanium oxide nanoparticles (TiO(2)-NP) on UMR106 cells with 24h exposure showed that SiO(2)@TiO(2) colloidal particles were less toxic than TiO(2)-NP.
authors.affiliation: CEQUINOR and Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas, UNLP. 47 y 115 (1900) La Plata, Argentina.
authors.forename: A L
authors.initials: AL
authors.lastname: Di Virgilio
authors.forename: I
authors.initials: I
authors.lastname: Maisuls
authors.forename: F
authors.initials: F
authors.lastname: Kleitz
authors.forename: P M
authors.initials: PM
authors.lastname: Arnal
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry / Q000633:toxicity*; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010316:Particle Size; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry / Q000633:toxicity*; D014025:Titanium / Q000737:chemistry / Q000633:toxicity*
chemical_list: D003603:Cytotoxins; D009153:Mutagens; D017382:Reactive Oxygen Species; C009495:titanium dioxide; D012822:Silicon Dioxide; D014025:Titanium