title: Downstream hepatic arterial blood pressure changes caused by deployment of the surefire antireflux expandable tip.
abstract: OBJECTIVE
  The purpose of this work was to evaluate blood pressure changes caused by deployment of the Surefire antireflux expandable tip. The pressure measurements are relevant because they imply changes in hepatoenteric arterial blood flow within this liver compartment during hepatic artery delivery of cytotoxic agents.
  
  
  METHODS
  After positioning the Surefire antireflux system in the targeted hepatic artery, blood pressure was obtained initially with the tip collapsed (or through a femoral artery sheath), then again after the tip was expanded before chemoembolization or yttrium 90 ((90)Y) radioembolization.
  
  
  RESULTS
  Eighteen patients with liver malignancy underwent 29 procedures in 29 hepatic arteries (3 common hepatic, 22 lobar, 4 segmental). Systolic, diastolic, and mean blood pressure were all decreased by a mean of 29 mm Hg (p = 0.000004), 14 mm Hg (p = 0.0000004), and 22 mm Hg (p = 0.00000001), respectively.
  
  
  CONCLUSIONS
  When the Surefire expandable tip is deployed to prevent retrograde reflux of agents, it also results in a significant decrease in blood pressure in the antegrade distribution, potentially resulting in hepatopedal blood flow in vessels that are difficult to embolize, such as the supraduodenal arteries.
authors.affiliation: Department of Radiology 8756, UCSD Medical Center, University of California, San Diego Health Sciences, 200 West Arbor Drive, San Diego, CA, 92103-8756, USA, scrose@ucsd.edu.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Rose
authors.forename: Steven G
authors.initials: SG
authors.lastname: Kikolski
authors.forename: James E
authors.initials: JE
authors.lastname: Chomas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D001795:Blood Pressure Determination / Q000379:methods; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D005260:Female; D006499:Hepatic Artery / Q000503:physiopathology*; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged