title: [Research of preparation craft of Danshen phenolic acid fast release unit in multi-drug delivery system of Tongmai micro-pellets].
abstract: OBJECTIVE
  To prepare Danshen phenolic acid fast release micro-pellets and study its preparation craft.
  
  
  METHODS
  The factors which could impact yield, extrude shaping, dissolution of Danshen phenolic acid micro-pellets such as wetting agent, drug loading dose, adjuvant, lactose dose, disintegrant, CMS-Na dose and wetting agent dose was investigated. The optimum preparation craft of Danshen phenolic acid fast release micro-pellets was screened out by orhogonal design.
  
  
  RESULTS
  Formula of Danshen phenolic acid fast release micro-pellets was calculated as volume dose 50 g. The formula was as follows: principal agent 22.5 g, lactose 5 g, CMS-Na 2 g, MCC 20.5 g, 27 mL 30% ethanol as wetting agent. Extrusion-spheronization was applied. The optimum conditions were screened out as follows: extrusion frequency (25 Hz), spheronization machine frequency (50 Hz), spheronization time (4 min).
  
  
  CONCLUSIONS
  The process was scientific and rational. The preparation is stable settles basis for multi-drug delivery system of Tongmai micro-pellets.
authors.affiliation: Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. jeromechen@126.com
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
authors.forename: Yang
authors.initials: Y
authors.lastname: Huang
mesh_terms: D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000737:chemistry*; D002482:Cellulose / Q000008:administration & dosage; D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D005079:Excipients / Q000008:administration & dosage / Q000737:chemistry; D062385:Hydroxybenzoates / Q000008:administration & dosage*; D007785:Lactose / Q000008:administration & dosage; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D002317:Cardiovascular Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005079:Excipients; D062385:Hydroxybenzoates; D002482:Cellulose; C017616:phenolic acid; D007785:Lactose