title: Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment.
abstract: We identified novel mechanisms whereby TIM-3 suppresses innate immunity as induced by nucleic acids. Interaction of TIM-3 with HMGB1 inhibits the recruitment of nucleic acids to the endosomal compartment of dendritic cells, impairing the transduction of innate immune signals. Thus, TIM-3 is an effective target for enhancing the immunogenicity of nucleic acids in the context of cancer therapy.
authors.affiliation: Research Center for Infection-Associated Cancer; Institute for Genetic Medicine; Hokkaido University; Sapporo, Japan.
authors.forename: Masahisa
authors.initials: M
authors.lastname: Jinushi