title: Efficacy of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis.
abstract: OBJECTIVE
  The aim of this study was to investigate the effectiveness of triamcinolone acetonide (TA) and salvianolic acid B (SA-B) intralesional combined injection in the treatment of oral submucous fibrosis (OSF).
  
  
  METHODS
  A randomized clinical trial was performed. TA, SA-B, and TA combined with SA-B were consecutively applied intralesionally weekly for 20 weeks. Mouth opening and burning sensation improvement as determined by a 100-mm visual analog scale were evaluated at weeks 10, 20, and 44.
  
  
  RESULTS
  Forty-two subjects fulfilled the study without obvious adverse reactions. The net gain in mouth opening was 2.00 ± 1.21 mm in the TA group, 3.48 ± 2.23 mm in the SA-B group, and 5.50 ± 1.80 mm in the TA + SA-B group at week 44. The burning sensation improved by 3.05 ± 0.76 in the TA group, 4.96 ± 0.97 in the SA-B group, and 6.11 ± 0.93 in the TA + SA-B group by the end of the study.
  
  
  CONCLUSIONS
  TA + SA-B intralesional injections improved mouth open and burning sensation in these OSF patients.
authors.affiliation: Department of Stomatology, First People's Hospital of Chenzhou, Chenzhou, Hunan, China. jxw0927@yahoo.com.cn
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Jiang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shou-Kang
authors.initials: SK
authors.lastname: Yang
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Lu
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Sun
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001572:Benzofurans / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects; D009914:Oral Submucous Fibrosis / Q000188:drug therapy*; D010147:Pain Measurement; D010292:Paresthesia / Q000188:drug therapy; D027561:Salvia miltiorrhiza; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use*; D053630:Depsides
chemical_list: D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005938:Glucocorticoids; D014222:Triamcinolone Acetonide; C076944:salvianolic acid B; D053630:Depsides