title: SULT1A1 genetic polymorphisms and the association between smoking and oral cancer in a case-control study in Brazil.
abstract: BACKGROUND
  Oral cancer is a public health problem worldwide, being tobacco and alcohol consumption their main risk factors. Sulfotransferase (SULT) 1A1 (encoded by SULT1A1) is involved in procarcinogens metabolism, such as polycyclic aromatic hydrocarbons (PAHs) present in tobacco smoke.
  
  
  OBJECTIVE
  The aim of this study was to explore the magnitude of association between SULT1A1 gene Arg(213)His polymorphism and oral cancer, and to explore the interaction between such polymorphism and smoking.
  
  
  METHODS
  A hospital-based case-control study was carried out in Rio de Janeiro, Brazil, during 1999-2002. Epidemiological data and biological samples were obtained from 202 oral cancer patients and 196 sex and age-frequency matched controls without cancer antecedents.
  
  
  RESULTS
  No association was observed between Arg(213)His SULT1A1 polymorphism and oral cancer risk in overall analysis (OR = 1.06, 95% CI = 0.71-1.57). The magnitude of association between cigarette smoking and oral cancer was higher in individuals with a SULT1A1(*)1 isoform (wild type, genotype Arg/Arg) (OR = 10.19, 95% CI = 3.90-26.61) than in those with at least one SULT1A1(*)2 allele (genotypes Arg/His + His/His) (OR = 4.50, 95% CI =2.09-9.69).
  
  
  CONCLUSIONS
  Our results suggest that Arg(213)His SULT1A1 polymorphism may modulate the association between smoking and oral cancer. However, this association needs to be replicated in other studies: due to modest number of cases and controls, the role of chance in the observed association cannot be ruled out.
authors.affiliation: National School of Public Health/FIOCRUZ Rio de Janeiro, Brazil.
authors.forename: Sabrina S
authors.initials: SS
authors.lastname: Santos
authors.forename: Rosalina J
authors.initials: RJ
authors.lastname: Koifman
authors.forename: Rafaela M
authors.initials: RM
authors.lastname: Ferreira
authors.forename: Lilian F
authors.initials: LF
authors.lastname: Diniz
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Sergio
authors.initials: S
authors.lastname: Koifman