title: Transcriptional and epigenetic regulation of human microRNAs.
abstract: MicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular cancers. Transcriptional regulation, post-transcriptional regulation, as well as genetic alterations, are the three major mechanisms controlling the spatial and temporal expression of miRNAs. Emerging evidence now indicates that transcriptional and epigenetic regulations play major roles in miRNA expression. This review summarizes the current knowledge and discusses the future challenges.
authors.affiliation: Brain Tumour Centre and Division of Neurosurgery, Department of Surgery, Chinese University of Hong Kong, Hong Kong.
authors.forename: Zifeng
authors.initials: Z
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Yao
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhu
authors.forename: Zan
authors.initials: Z
authors.lastname: Shen
authors.forename: Gang
authors.initials: G
authors.lastname: Lu
authors.forename: Wai Sang
authors.initials: WS
authors.lastname: Poon
authors.forename: Dan
authors.initials: D
authors.lastname: Xie
authors.forename: Marie Chia-mi
authors.initials: MC
authors.lastname: Lin
authors.forename: Hsiang-fu
authors.initials: HF
authors.lastname: Kung
mesh_terms: D057890:Epigenomics; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs