title: Donepezil abolishes anticholinergic activity in a patient with amnesia.
abstract: We report the case of a 74-year-old woman who presented with amnesia and positive serum anticholinergic activity (SAA), which disappeared after treatment with the cholinesterase inhibitor donepezil for 1 year. Her only other regular medications were topical glaucoma preparations. We suggest that mental stress, mild cognitive impairment and Alzheimer's disease pathology combined to generate SAA in this patient. We also consider that SAA may have subsequently become negative because of upregulation of acetylcholine production by donepezil, and because the patient's other medications and physical condition (including glaucoma) remained unchanged during the 1-year period.
authors.affiliation: Department of Psychiatry, Showa University Northern Yokohama Hospital, Yokohama, Japan.
authors.forename: Kimiko
authors.initials: K
authors.lastname: Konishi
authors.forename: Koji
authors.initials: K
authors.lastname: Hori
authors.forename: Hiroi
authors.initials: H
authors.lastname: Tomioka
authors.forename: Genshin
authors.initials: G
authors.lastname: Minegishi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tani
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Ryo
authors.initials: R
authors.lastname: Akita
authors.forename: Sachiko
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Tomonori
authors.initials: T
authors.lastname: Oshio
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Hachisu
mesh_terms: D000368:Aged; D000647:Amnesia / Q000175:diagnosis / Q000188:drug therapy*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000188:drug therapy*; D000077265:Donepezil; D005260:Female; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D018697:Nootropic Agents / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil