title: Chemoselective acylation of (hydroxyalkyl)phenols catalyzed by Candida antarctica lipase B.
abstract: Acylation of (hydroxyalkyl)phenols with vinyl esters by lipase B from Candida antarctica proceeded smoothly in a highly chemoselective manner, affording their alkyl esters exclusively or at least predominantly. The enzyme therefore discriminates between an alcoholic hydroxyl from a phenolic hydroxyl in addition to having versatile catalytic abilities for organic synthesis.
authors.affiliation: Department of Chemistry, Faculty of Science and Engineering, Konan University, Higashinada-ku, Kobe 658-8501, Japan. miyazawa@konan-u.ac.jp
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Masato
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Danjo
mesh_terms: D000215:Acylation; D002175:Candida / Q000201:enzymology*; D005656:Fungal Proteins / Q000378:metabolism*; D008049:Lipase / Q000378:metabolism*; D010636:Phenols / Q000378:metabolism*; D014753:Vinyl Compounds / Q000378:metabolism
chemical_list: D005656:Fungal Proteins; D010636:Phenols; D014753:Vinyl Compounds; D008049:Lipase; C431349:lipase B, Candida antarctica; C011566:vinyl acetate