title: [Mechanism of Nampt gene expression regulation].
abstract: Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B cell colony-enhancing factor (PBEF) or visfatin, is a crucial rate-limiting enzyme of NAD biosynthetic pathway. It may affect the metabolism, inflammatory response, cell proliferation, differentiation, and apoptosis, especially the aging and other physiological progresses through regulating NAD biosynthesis and nonenzyme routes in the organisms and cells. This review mainly focuses on recent progresses in the expression modulation and feedback regulation of Nampt gene.
authors.affiliation: College of Life, Anhui Normal University, Wuhu 241000, China. hhhrrr_hr@126.com
authors.forename: Rui
authors.initials: R
authors.lastname: Huang
authors.forename: Zi-Ru
authors.initials: ZR
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Gang
authors.initials: G
authors.lastname: Zhang
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Lu
mesh_terms: D000818:Animals; D025461:Feedback, Physiological; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008322:Mammals / Q000235:genetics* / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D054409:Nicotinamide Phosphoribosyltransferase / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D014157:Transcription Factors; D009243:NAD; D054409:Nicotinamide Phosphoribosyltransferase