title: Bilateral necrobiotic xanthogranuloma of the eyelids followed by a diagnosis of multiple myeloma 20 years later.
abstract: A uniquely indolent case of necrobiotic xanthogranuloma with bilateral, periorbital involvement was presented. This patient presented with cutaneous eyelid lesions of 20 years' duration. Although symptomless, the patient underwent testing for hematologic malignancy, which led to a diagnosis of multiple myeloma. A review of the literature revealed that this is the longest interval between the onset of the skin manifestations and the diagnosis of the systemic malignancy in this rare disease.
authors.affiliation: Departments of *Ophthalmology, †Pathology, and ‡Medicine (Hematology), University of Ottawa, The Ottawa Hospital, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
authors.forename: Kay
authors.initials: K
authors.lastname: Lam
authors.forename: Seymour
authors.initials: S
authors.lastname: Brownstein
authors.forename: David R
authors.initials: DR
authors.lastname: Jordan
authors.forename: Richard
authors.initials: R
authors.lastname: van der Jagt
authors.forename: André
authors.initials: A
authors.lastname: Jastrzebski
authors.forename: Michel A
authors.initials: MA
authors.lastname: Dionne
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D005141:Eyelid Diseases / Q000175:diagnosis* / Q000378:metabolism; D017809:Fatal Outcome; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D009101:Multiple Myeloma / Q000097:blood / Q000175:diagnosis*; D058252:Necrobiotic Xanthogranuloma / Q000175:diagnosis* / Q000378:metabolism; D010265:Paraproteinemias / Q000175:diagnosis
chemical_list: D015703:Antigens, CD; D007074:Immunoglobulin G