title: [Nodular lymphoid hyperplasia - a rare case of lymphoproliferative disorder of the lungs].
abstract: Nodular lymphoid hyperplasia (NLH) belongs to a very rare, mild, lymphoproliferative disease of unestablished aetiology  historically included in the group of pseudolymphomas. Its existence was controversial for many years, until modern  techniques of pathomorphological diagnosis approved it as a separate entity of lung disease. It manifests in the form of well  limited nodules localized in the lungs, which are mostly identified accidentally. Clinical symptoms are rare and nonspecific;  the disease usually occupies only one lung. Pathomorphological diagnosis requires immunohistochemical designation of  expressions of numerous antigens in order to exclude malignant lymphoma of the lungs. Surgical resection is used in cases  of larger nodules; the smaller ones require periodic observation, and the prognosis is good. The authors describe the case of  65-year-old woman with pulmonary nodules which were detected accidentally in the right lung. The patient was qualified for  right-sided videothoracoscopy and removal of the lung nodule. In classic HE staining of the histological material, the  presence of lymphoid infiltration of the lungs was revealed, which formed lymph follicles with reactive germinal centres.  In order to differentiate from the malignant lymphatic expansion, immunohistochemical designations were made, which  showed positive expression of CD20 antigen in the B cell zone, positive expression of the CD3 antigen in the T cells zone,  positive expression of CD23 antigen in the lymph follicles, negative expression of bcl-2 in the lymph follicles, and positive  expression of MIB-1 in the germinal centres of lymph follicles. Such a histopathological and immunohistochemical picture  provided the basis for diagnosis of nodular lymphoid hyperplasia of the lung.
authors.affiliation: Oddział Chirurgii Klatki Piersiowej, Centrum Pulmonologii i Torakochirurgii w Bystrej. progozinski81@gmail.com
authors.forename: Paweł
authors.initials: P
authors.lastname: Rogoziński
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Bruliński
authors.forename: Eugeniusz
authors.initials: E
authors.lastname: Malinowski
authors.forename: Piotr
authors.initials: P
authors.lastname: Wandzel
authors.forename: Marek
authors.initials: M
authors.lastname: Kucharzewski
mesh_terms: D000368:Aged; D000941:Antigens / Q000032:analysis; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis / Q000276:immunology / Q000601:surgery; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D055613:Multiple Pulmonary Nodules / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D035583:Rare Diseases
chemical_list: D000941:Antigens