title: Airway distension during lung inflation in healthy and allergic-sensitised mice in vivo.
abstract: We evaluated the airway distention during lung inflation of varying size in healthy and allergic-sensitised mice in vivo. Computed tomography (CT) images of healthy and ovalbumin-treated mice were acquired using a synchrotron in vivo CT system when lung pressures was 0 and 20 cmH(2)O, and the morphometric distension (diameter, length, and volume) and the compliance of airway segments (to as small as ~150 μm internal diameter) were calculated. With respect to airway size, in healthy mice, the changes in airway diameter and compliance were larger in the small-airway group. In contrast, in allergic-sensitised mice, there were no significant differences in the changes in airway distension or compliance. Airway wall thickness in allergic-sensitised mice increased significantly in all airway groups, but the change was much larger in the small than in the large-airway group. Compared with healthy airways, the changes in diameter and airway compliance of the allergic-sensitised mice were significantly smaller in the small-airway group.
authors.affiliation: The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-15, Yamadaoka, Suita, Osaka 565-0871, Japan. sera@me.es.osaka-u.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Sera
authors.forename: Hideo
authors.initials: H
authors.lastname: Yokota
authors.forename: Kentaro
authors.initials: K
authors.lastname: Uesugi
authors.forename: Naoto
authors.initials: N
authors.lastname: Yagi
mesh_terms: D000818:Animals; D008168:Lung / Q000000981:diagnostic imaging*; D008170:Lung Compliance; D008297:Male; D051379:Mice; D012130:Respiratory Hypersensitivity / Q000000981:diagnostic imaging*; D012143:Respiratory Physiological Phenomena; D014057:Tomography, X-Ray Computed