title: Evaluation of hemodynamic changes by use of phase-contrast MRI for patients with interstitial pneumonia, with special focus on blood flow reduction after breath-holding and bronchopulmonary shunt flow.
abstract: OBJECTIVE
  The purpose of this study was to determine the effects of interstitial pneumonia on pulmonary, systemic, and bronchopulmonary shunt flow.
  
  
  METHODS
  Phase-contrast flow measurements in the ascending aorta and pulmonary trunk were performed during free breathing and inspiratory breath-holding by use of a 1.5 T MR scanner. The study population comprised 11 patients with interstitial pneumonia and 15 healthy volunteers. Absolute blood flow, bronchopulmonary shunt flow, and difference in flow between normal breathing and breath-holding were compared between the groups.
  
  
  RESULTS
  Both pulmonary and systemic blood flow during both breathing patterns in patients were significantly reduced compared with the volunteers (p < 0.05). However, bronchopulmonary shunt flow and reduction of systemic and pulmonary artery flow did not differ between groups.
  
  
  CONCLUSIONS
  Interstitial pneumonia reduces both pulmonary and systemic blood flow, but it does not affect the amount of flow reduction during breath-holding. The bronchopulmonary shunt was not increased in interstitial pneumonia patients, probably because of stiffness of the bronchial arteries.
authors.affiliation: Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, 207, Uehara, Nishighara-cho, Nakagami-Gun, Okinawa 903-0215, Japan. nanae7a50@hotmail.com
authors.forename: Nanae
authors.initials: N
authors.lastname: Tsuchiya
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ayukawa
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Murayama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D062485:Breath Holding; D016022:Case-Control Studies; D003287:Contrast Media; D005260:Female; D006439:Hemodynamics; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011652:Pulmonary Circulation; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media