title: Experimental infection of pregnant cows with noncytopathogenic bovine viral diarrhoea virus between days 26 and 50 postbreeding.
abstract: The effect of bovine viral diarrhoea virus (BVDV) infection on early pregnant cows between 10 and 24 days after virus inoculation at day 26 of pregnancy was determined. Four cows were inoculated intravenously with either BVDV (treated, n=3) or growth medium (control, n=1). The treated cows were euthanized on either day 10, 17 or 24 post-infection and the control cow was euthanized on day 24 post-infection. The level of serum 2-5A synthetase increased in all of the three treated cows. Progesterone levels decreased to below 1.0 ng/ml between 10 and 22 days after inoculation in two of the three treated cows and the embryos/foetuses of two cows died. Therefore, BVDV may be a cause of early embryonic or feotal loss in early pregnant cows and serum 2-5A synthetase may be useful as an indicator of viral infection in cows.
authors.affiliation: Viral Disease and Epidemiology Research Division, Tohoku Research Station, National Institute of Animal Health, Shichinohe, Kamikita, Aomori 039-2586, Japan. tsuboi@affrc.go.jp
authors.forename: T
authors.initials: T
authors.lastname: Tsuboi
authors.forename: T
authors.initials: T
authors.lastname: Osawa
authors.forename: T-I
authors.initials: TI
authors.lastname: Hirata
authors.forename: K
authors.initials: K
authors.lastname: Kawashima
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Haritani
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000097:blood; D000031:Abortion, Septic / Q000662:veterinary / Q000821:virology; D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000097:blood / Q000473:pathology / Q000821:virology*; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral; D005260:Female; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D011374:Progesterone / Q000097:blood
chemical_list: D011374:Progesterone; D015088:2',5'-Oligoadenylate Synthetase