title: Ceramic nanocarriers: versatile nanosystem for protein and peptide delivery.
abstract: BACKGROUND
  Proteins and peptides have been established to be the potential drug candidate for various human diseases. But, delivery of these therapeutic protein and peptides is still a challenge due to their several unfavorable properties. Nanotechnology is expanding as a promising tool for the efficient delivery of proteins and peptides. Among numerous nano-based carriers, ceramic nanoparticles have proven themselves as a unique carrier for protein and peptide delivery as they provide a more stable, bioavailable, readily manufacturable, and acceptable proteins and polypeptide formulation.
  
  
  METHODS
  This article provides an overview of the various aspects of ceramic nanoparticles including their classification, methods of preparation, latest advances, and applications as protein and peptide delivery carriers.
  
  
  CONCLUSIONS
  Ceramic nanocarriers seem to have potential for preserving structural integrity of proteins and peptides, thereby promoting a better therapeutic effect. This approach thus provides pharmaceutical scientists with a new hope for the delivery of proteins and peptides. Still, considerable study on ceramic nanocarrier is necessary with respect to pharmacokinetics, toxicology, and animal studies to confirm their efficiency as well as safety and to establish their clinical usefulness and scale-up to industrial level.
authors.affiliation: University Institute of Pharmacy, Pharmaceutical Biotechnology, Pt. Ravishankar Shukla University, Raipur (C.G.), India.
authors.forename: Deependra
authors.initials: D
authors.lastname: Singh
authors.forename: Pooja
authors.initials: P
authors.lastname: Dubey
authors.forename: Madhulika
authors.initials: M
authors.lastname: Pradhan
authors.forename: Manju Rawat
authors.initials: MR
authors.lastname: Singh
mesh_terms: D000818:Animals; D002516:Ceramics / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D010455:Peptides / Q000008:administration & dosage*; D004364:Pharmaceutical Preparations; D011506:Proteins / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D010455:Peptides; D004364:Pharmaceutical Preparations; D011506:Proteins