title: [A patient with unresectable progressive advanced rectal cancer maintained in a state of remission by using combination therapy].
abstract: We report the case of a patient with unresectable progressive advanced rectal cancer, who has been able to maintain a good quality of life because of combination therapy, including chemoradiotherapy. A 52-year-old woman was diagnosed with progressive locally advanced rectal cancer and invasion of the adnexa of the uterus and the left ureter. No distant metastasis was detected. Colostomy was performed, followed by chemoradiotherapy combined with S-1; then, mFOLFOX6 +bevacizumab (BV) therapy was administered. Aggravation of bilateral hydronephrosis was detected upon completion of 2 courses of treatment, and therefore, percutaneous nephrostomy of the right kidney was performed. After the patient underwent 20 courses of treatment, imaging showed a reduction in the size of the lesion, and the CEA level returned to normal. Later, remission was sustained by sLV5FU2+BV therapy and oral administration of S-1. As a result, we were able to remove the nephrostomy tube from the right kidney in February 2011. Four years after initiation of the treatment, the patient has shown no indication of recurrence.
authors.affiliation: Dept. of Surgery, Shuuwa General Hospital, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kuwabara
authors.forename: Yohei
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Hironobu
authors.initials: H
authors.lastname: Baba
authors.forename: Akito
authors.initials: A
authors.lastname: Mitsuoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sanada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Baba
authors.forename: Narihide
authors.initials: N
authors.lastname: Goseki
authors.forename: Masanori
authors.initials: M
authors.lastname: Hodotsuka
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Sano
mesh_terms: D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000473:pathology / Q000628:therapy*; D012074:Remission Induction