title: Apoptosis in cancer--an update.
abstract: Apoptosis is programmed cell death which is essential for development and survival of living organisms. It is a sequentially regulated suicidal programme where cells activate certain enzymes which dissolute their own nuclear component and various protein component of nucleus and cytoplasm. Disturbance of this regulatory pathway may lead to various diseases like autoimmune diseases, neurodegenerative diseases and cancers. The potential mechanisms of apoptosis and its role in cancer are discussed. The ability of apoptosis to modulate the life or death of a cell is also recognized for its immense therapeutic potential. Understanding the mechanisms from this review will give us better insight to the pathogenesis of various diseases including cancer and will open new horizons to therapeutic approaches.
authors.affiliation: Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath University, Chennai, India.
authors.forename: S Leena
authors.initials: SL
authors.lastname: Sankari
authors.forename: K M K
authors.initials: KM
authors.lastname: Masthan
authors.forename: N Aravindha
authors.initials: NA
authors.lastname: Babu
authors.forename: Tathagata
authors.initials: T
authors.lastname: Bhattacharjee
authors.forename: M
authors.initials: M
authors.lastname: Elumalai
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents