title: Stevens-Johnson syndrome progressing to toxic epidermal necrolysis with haloperidol and carbamazepine combination.
abstract: Carbamazepine and other anticonvulsants are commoner cause of severe adverse cutaneous drug reactions such as erythema multiforme, toxic epidermal necrolysis (TEN), and Stevens-Johnson syndrome (SJS). We report a case of SJS rapidly progressing to TEN with a combination of haloperidol and carbamazepine in a patient with bipolar affective disorder. The pathophysiological mechanism underlying this reaction is discussed.
authors.affiliation: Army College of Medical Sciences, Delhi Cantt., Delhi, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.forename: Sukanto
authors.initials: S
authors.lastname: Sarkar
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Praharaj
authors.forename: Sayeed
authors.initials: S
authors.lastname: Akhtar
authors.forename: M
authors.initials: M
authors.lastname: Diwakar