title: Comparison of transdermal electromotive administration of verapamil and dexamethasone versus intra-lesional injection for Peyronie's disease.
abstract: To compare the efficacy of transdermal electromotive administration and intra-lesional injection of verapamil plus dexamethasone for the treatment of Peyronie's disease. Patients with Peyronie's disease of less than 2-year duration were randomized into two groups of transdermal electromotive administration and intra-lesional injection of verapamil plus dexamethasone. During the 6-week therapy period, a single weekly dose of 10 mg verapamil and 4 mg dexamethasone solution was administered to 30 patients in each group either by transdermal electromotive method or via the conventional injection method by a syringe connected to a 25 G needle. Evaluations of plaque length, width, and volume, penile curvature, erectile dysfunction and penile deviations were carried out before and after 1 and 3 months of the interventions. Erectile pain was reduced in the electromotive group from a mean of 5.1-1.0 in scale of 10 and from 5.4 to 3.6 in the injection group (p = 0.006). Regarding plaque length, plaque width, penile curvature plaque volume and erectile dysfunction, the electromotive administration group showed better results which, however, were not statistically significant. (p > 0.05). Transdermal electromotive drug administration yielded comparable results as against current conventional intra-lesional injection technique and fared better in controlling erectile pain.
authors.affiliation: Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: A R
authors.initials: AR
authors.lastname: Mehrsai
authors.forename: F
authors.initials: F
authors.lastname: Namdari
authors.forename: A
authors.initials: A
authors.lastname: Salavati
authors.forename: S
authors.initials: S
authors.lastname: Dehghani
authors.forename: F
authors.initials: F
authors.lastname: Allameh
authors.forename: G
authors.initials: G
authors.lastname: Pourmand
mesh_terms: D000279:Administration, Cutaneous; D000704:Analysis of Variance; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D007478:Iontophoresis; D007492:Iran; D008297:Male; D010411:Penile Induration / Q000175:diagnosis / Q000188:drug therapy*; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014700:Verapamil / Q000008:administration & dosage*
chemical_list: D002121:Calcium Channel Blockers; D005938:Glucocorticoids; D003907:Dexamethasone; D014700:Verapamil