title: Prevalence and genetic variation of porcine circovirus type 2 in Taiwan from 2001 to 2011.
abstract: Porcine circovirus type 2 (PCV2) is the major causative agent of postweaning multisystemic wasting syndrome (PMWS) in Taiwanese pig farms. We analyzed the complete genomes of 571 Taiwanese PCV2 isolates in Taiwan from 2001 to 2011 and divided the isolates into 2 distinct genotypes (PCV2a and PCV2b) with 6 clusters (1A, 1B, 1C, 2B, 2D, and 2E). Of the 571 Taiwanese PCV2 isolates, 22.9% (131/571) belonged to PCV2a and 77.1% (440/571) to PCV2b. In this study, PCV2a isolates were the most common in 2001, and then PCV2b isolates became predominate thereafter and widely distributed in pig farms since 2003. Sequence comparisons among the 571 isolates indicated that 89.6-100% had nucleotide identity for complete genome and 87.3-100% for open reading frames 2 (ORF2). The results suggest that a higher genetic variation and shift occurred among PCV2 isolates collected from 2001 to 2011 in Taiwan.
authors.affiliation: Animal Health Research Institute, Council of Agriculture, Executive Yuan, No. 376, Chung-Cheng Rd., Tansui, New Taipei City 251, Taiwan, ROC.
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.forename: Victor Fei
authors.initials: VF
authors.lastname: Pang
authors.forename: Fan
authors.initials: F
authors.lastname: Lee
authors.forename: Tien-Shine
authors.initials: TS
authors.lastname: Huang
authors.forename: Shu-Hwae
authors.initials: SH
authors.lastname: Lee
authors.forename: Yu-Ju
authors.initials: YJ
authors.lastname: Lin
authors.forename: Yeou-Liang
authors.initials: YL
authors.lastname: Lin
authors.forename: Shiow-Suey
authors.initials: SS
authors.lastname: Lai
authors.forename: Chian-Ren
authors.initials: CR
authors.lastname: Jeng
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018173:Circoviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000235:genetics* / Q000302:isolation & purification; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D014644:Genetic Variation / Q000235:genetics; D016679:Genome, Viral / Q000235:genetics; D005838:Genotype; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000662:veterinary; D015995:Prevalence; D012641:Selection, Genetic / Q000235:genetics; D013552:Swine / Q000821:virology; D013553:Swine Diseases / Q000453:epidemiology / Q000821:virology*; D013624:Taiwan / Q000453:epidemiology
chemical_list: D004279:DNA, Viral