title: Clinical-radiological study on the role of biostimulating materials in iatrogenic furcation lesions.
abstract: Root perforation is an unwanted incident which may occur at any stage of endodontic treatment and can adversely affect tooth prognosis.
  
  
  OBJECTIVE
  To compare the recovery rate after treatment of root perforations in the interradicular area of the molars, using two different materials: MTA and ceramic nanoparticles mineral cement DiaRoot BioAggregate, by a clinical-radiological and statistical analysis over a period of up to 24 months.
  
  
  METHODS
  The study was conducted on 28 molars from patients of both sexes, mean age 33.29 +/- 6.2DS, with iatrogenic perforation of pulp chamber floor. The teeth were divided into 2 groups according to the applied material: group 1--gray MTA (ProRoot MTA, Dentsply, Tulsa Dental), and group 2--BioAggregate (Diadent Group International, Vancouver). Patients included in the study were monitored and assessed by radiological examinations at 6, 12 and 18 months.
  
  
  RESULTS
  Pulp chamber floor perforations are significantly associated with tooth location (chi2 = 35.60, r = 0.67, p = 0.00359, 95% CI). Both when the perforation was repaired with MTA and BioAggregate, the clinical improvement was significant (chi2 = 17.608, r = 0.58, p = 0.0035, 95% CI).
  
  
  CONCLUSIONS
  Based on the results of this study, both MTA and BioAggregate are excellent materials for root perforation repair.
authors.affiliation: Discipline of Endodontics, University of Medicine and Pharmacy, Grigore T. Popa--Iasi School of Dental Medicine.
authors.forename: Liana
authors.initials: L
authors.lastname: Aminov
authors.forename: Mihaela
authors.initials: M
authors.lastname: Moscalu
authors.forename: Anca
authors.initials: A
authors.lastname: Melian
authors.forename: Mihaela
authors.initials: M
authors.lastname: Salceanu
authors.forename: T
authors.initials: T
authors.lastname: Hamburda
authors.forename: Maria
authors.initials: M
authors.lastname: Vataman
mesh_terms: D000328:Adult; D000465:Algorithms; D017607:Aluminum Compounds / Q000008:administration & dosage*; D017610:Calcium Compounds / Q000008:administration & dosage*; D002126:Calcium Hydroxide / Q000008:administration & dosage*; D003786:Dental Pulp Cavity / Q000000981:diagnostic imaging / Q000293:injuries*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006882:Hydroxyapatites / Q000008:administration & dosage*; D008297:Male; D008963:Molar / Q000000981:diagnostic imaging / Q000293:injuries*; D010087:Oxides / Q000008:administration & dosage*; D011859:Radiography; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D017640:Silicates / Q000008:administration & dosage*; D014092:Tooth Root / Q000000981:diagnostic imaging / Q000293:injuries*; D016896:Treatment Outcome
chemical_list: D017607:Aluminum Compounds; C557009:BioAggregate; D017610:Calcium Compounds; D004338:Drug Combinations; D006882:Hydroxyapatites; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; D002126:Calcium Hydroxide