title: Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation.
abstract: Circulatory antigens transit through the small intestine via the fenestrated capillaries in the lamina propria prior to entering into the draining lymphatics. But whether or how this process controls mucosal immune responses remains unknown. Here we demonstrate that dendritic cells (DCs) of the lamina propria can sample and process both circulatory and luminal antigens. Surprisingly, antigen cross-presentation by resident CX3CR1(+) DCs induced differentiation of precursor cells into CD8(+) T cells that expressed interleukin-10 (IL-10), IL-13, and IL-9 and could migrate into adjacent compartments. We conclude that lamina propria CX3CR1(+) DCs facilitate the surveillance of circulatory antigens and act as a conduit for the processing of self- and intestinally absorbed antigens, leading to the induction of CD8(+) T cells, that partake in the control of T cell activation during mucosal immune responses.
authors.affiliation: Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Chang
authors.forename: Joo-Hye
authors.initials: JH
authors.lastname: Song
authors.forename: Bayasi
authors.initials: B
authors.lastname: Guleng
authors.forename: Carmen Alonso
authors.initials: CA
authors.lastname: Cotoner
authors.forename: Seiji
authors.initials: S
authors.lastname: Arihiro
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Hao-Sen
authors.initials: HS
authors.lastname: Chiang
authors.forename: Michael
authors.initials: M
authors.lastname: O'Keeffe
authors.forename: Gongxian
authors.initials: G
authors.lastname: Liao
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Karp
authors.forename: Mi-Na
authors.initials: MN
authors.lastname: Kweon
authors.forename: Arlene H
authors.initials: AH
authors.lastname: Sharpe
authors.forename: Atul
authors.initials: A
authors.lastname: Bhan
authors.forename: Cox
authors.initials: C
authors.lastname: Terhorst
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Reinecker
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000941:Antigens / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D000073883:CX3C Chemokine Receptor 1; D002454:Cell Differentiation / Q000276:immunology; D045142:Cross-Priming / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D004751:Enteritis / Q000276:immunology / Q000517:prevention & control; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D007421:Intestine, Small / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D019707:Receptors, Chemokine / Q000276:immunology / Q000378:metabolism
chemical_list: D000941:Antigens; D000073883:CX3C Chemokine Receptor 1; C471885:Cx3cr1 protein, mouse; D018984:Epitopes, T-Lymphocyte; D019707:Receptors, Chemokine