title: Preoperative regional cerebral blood flow and postoperative clinical improvement in patients with Parkinson's disease undergoing subthalamic nucleus deep brain stimulation.
abstract: Preoperative regional cerebral blood flow (rCBF) was measured in 92 patients with Parkinson's disease (PD) by iodine-123 N-isopropyl-p-iodoamphetamine single-photon emission computed tomography. Quantitative mapping of rCBF was performed using the stereotactic extraction estimation method. The clinical features of the patients were assessed according to the Unified Parkinson Disease Rating Scale (UPDRS). The correlation between rCBF and improvement in the UPDRS score following surgery was examined. rCBF in the fusiform gyrus, superior and inferior parietal gyri, middle occipital gyrus, superior frontal gyrus, and middle temporal gyrus of the Talairach Daemon Level 3 was significantly correlated with UPDRS part II (off stage) and III (on stage) scores (p < 0.05). rCBF in the middle temporal gyrus (p = 0.00147), medial frontal gyrus (p = 0.00713), and cerebellum (p = 0.048) of the Talairach Daemon Level 3 was significantly greater in 47 patients with >60% improvement of UPDRS part III (off stage) score than in 37 patients with 40-60% improvement. The cutoff value of rCBF, which indicated that >40% improvement in the surgical outcome could be expected, was 38.8 ± 6.2 ml/100 g/min in the frontal lobe. This study indicated that rCBF in patients with PD might be related to their clinical features, suggesting that quantitative mapping of rCBF may be useful for predicting surgical outcome.
authors.affiliation: Department of Neurosurgery, Nagoya University, Graduate School of Medicine, Nagoya, Aichi.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Nagai
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Kajita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Maesawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakatsubo
authors.forename: Kota
authors.initials: K
authors.lastname: Yoshida
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kato
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Wakabayashi
mesh_terms: D000368:Aged; D001345:Autoradiography; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D020367:Iofetamine; D007564:Japan; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D011183:Postoperative Complications / Q000175:diagnosis* / Q000503:physiopathology*; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow / Q000502:physiology*; D020531:Subthalamic Nucleus / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D020367:Iofetamine