title: Polyurethanes containing zwitterionic sulfobetaines and their molecular chain rearrangement in water.
abstract: Novel polyurethanes with zwitterionic sulfobetaines, termed PUR-APS, were designed and synthesized by chain-extension of biodegradable poly(ε-caprolactone) containing N,N'-bis (2-hydroxyethyl) methylamine ammonium propane sulfonate (PCL-APS) with hexamethylene diisocyanate (HDI). The bulk properties of polymers were characterized by nuclear magnetic resonance spectrum (NMR), Fourier transform infrared spectroscopy (FTIR), gel permeation chromatograph (GPC), and differential scanning calorimetry (DSC). Results showed that the polymers were successfully synthesized. Water contact angles (WCAs) and X-ray photoelectron spectroscopy (XPS) revealed that molecular chains of the polymers rearranged after soaking in water. The amount of protein adsorption, determined by bicinchoninic acid (BCA) assay, was less than 300 ng/cm(2) and decreased after hydration. The blood compatibility of the polymers was evaluated by the degree of hemolytic and activated partial thromboplastic time (APTT) and prothrombin time (PT). Results indicated that PUR-APS polymers had good blood compatibility. Therefore, polyurethanes containing sulfobetaines have a great potential for biomedical application.
authors.affiliation: College of Polymer Science and Engineering of Sichuan University, Sichuan University, Sichuan 610065, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.forename: Mou
authors.initials: M
authors.lastname: Yang
authors.forename: Aijing
authors.initials: A
authors.lastname: Lu
authors.forename: Shuying
authors.initials: S
authors.lastname: Zhai
authors.forename: Yuanwei
authors.initials: Y
authors.lastname: Chen
authors.forename: Xianglin
authors.initials: X
authors.lastname: Luo
mesh_terms: D000327:Adsorption; D000818:Animals; D001622:Betaine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002417:Cattle; D006461:Hemolysis / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D015394:Molecular Structure; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D011091:Polyesters; D011140:Polyurethanes; D014867:Water; C016240:polycaprolactone; D012710:Serum Albumin, Bovine; D001622:Betaine; C483727:sulfobetaine