title: Expression of the CXCL12/SDF-1 chemokine receptor CXCR7 in human brain tumours.
abstract: OBJECTIVE
  Receptor 7 (CXCR7) has recently been characterized as a novel receptor for CXCL12/SDF-1 (stromal cell derived factor-1). Given the demonstrated importance of CXCL12/SDF-1 in angiogenesis and tumour metastasis, we hypothesized that CXCR7 may also play a role in tumour pathogenesis. Located in the limited space of the intracranial cavity, any brain tumours can be inherently serious and life-threatening. However, the expression of CXCR7 in pituitary adenoma, neurilemmoma or hemangioblastoma remains to be elucidated. Therefore, we aimed to determine the potential contribution of CXCR7 in the development of brain tumours.
  
  
  METHODS
  In this study we examined and quantified the mRNA expression of CXCR7 in four different human brain tumours - 27 patients with neurilemmoma (8 patients), pituitary adenoma (7 patients), hemangioblastoma (6 patients), or meningioma (6 patients) undergoing surgical resection in the West China Hospital of Sichuan University. There were 15 females and 12 males aged from 28 to 70 years old. Total RNA was isolated and mRNA was measured by quantitative real-time RT-PCR. One-way analysis of variance (ANOVA) was performed using SPSS 11.0 statistical software to compare the mRNA levels of CXCR7 among four groups.
  
  
  RESULTS
  We found that CXCR7 mRNA was detected in all tumour samples. Quantitative results showed that the levels of CXCR7 mRNA in brain tissues from patients with neurilemmoma or meningioma were significantly higher than those with pituitary adenoma or hemangioblastoma.
  
  
  CONCLUSIONS
  The results suggest that the CXCR7 may play a role in progression, metastasis and angiogenesis of brain tumours.
authors.affiliation: West China Medical School, Sichuan University, Chengdu, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Tang
authors.forename: Qing-Jie
authors.initials: QJ
authors.lastname: Xia
authors.forename: Jian-Bin
authors.initials: JB
authors.lastname: Chen
authors.forename: Ming-Rong
authors.initials: MR
authors.lastname: Xi
authors.forename: Ding
authors.initials: D
authors.lastname: Lei
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008579:Meningioma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009442:Neurilemmoma / Q000235:genetics* / Q000473:pathology; D010911:Pituitary Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D054387:Receptors, CXCR / Q000235:genetics*
chemical_list: C501896:ACKR3 protein, human; D014408:Biomarkers, Tumor; D054387:Receptors, CXCR