title: Cilia, calcium and the basis of left-right asymmetry.
abstract: The clockwise rotation of cilia in the developing mammalian embryo drives a leftward flow of liquid; this genetically regulated biophysical force specifies left-right asymmetry of the mammalian body. How leftward flow is interpreted and information propagated to other tissues is the subject of debate. Four recent papers have shed fresh light on the possible mechanisms.
authors.affiliation: Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK. d.norris@har.mrc.ac.uk
authors.forename: Dominic P
authors.initials: DP
authors.lastname: Norris
mesh_terms: D000818:Animals; D019521:Body Patterning; D002118:Calcium / Q000378:metabolism*; D002450:Cell Communication; D002923:Cilia / Q000378:metabolism*; D008322:Mammals / Q000196:embryology; D008954:Models, Biological; D015398:Signal Transduction
chemical_list: D002118:Calcium