title: Leflunomide-induced DRESS syndrome with renal involvement and vasculitis.
abstract: DRESS or drug reaction (or rash) with eosinophilia and systemic symptoms belongs to the severe cutaneous adverse reaction group and is characterized by hematological abnormalities and visceral organ involvement. Although most often related with anticonvulsant and sulfonamide use, it is reported with numerous other drugs. We report an unusual case of DRESS syndrome due to Leflunomide, also complicated by renal involvement in the form of granulomatous interstitial nephritis and vasculitis. On a review of the literature, eight similar cases were found, and these are discussed.
authors.affiliation: Department of Internal Medicine (Rheumatology Unit), Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Benzeeta
authors.initials: B
authors.lastname: Pinto
authors.forename: Varun
authors.initials: V
authors.lastname: Dhir
authors.forename: Sabari
authors.initials: S
authors.lastname: Krishnan
authors.forename: Ritambhra
authors.initials: R
authors.lastname: Nada
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects; D001706:Biopsy; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology*; D004802:Eosinophilia / Q000378:metabolism; D004890:Erythema / Q000209:etiology; D005076:Exanthema / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects*; D007674:Kidney Diseases / Q000139:chemically induced*; D000077339:Leflunomide; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000150:complications; D013997:Time Factors; D016896:Treatment Outcome; D014652:Vascular Diseases / Q000139:chemically induced*
chemical_list: D018501:Antirheumatic Agents; D007555:Isoxazoles; D000077339:Leflunomide