title: Asymmetric trienamine catalysis: new opportunities in amine catalysis.
abstract: Amine catalysis, through HOMO-activating enamine and LUMO-activating iminium-ion formation, is receiving increasing attention among other organocatalytic strategies, for the activation of unmodified carbonyl compounds. Particularly, the HOMO-raising activation concept has been applied to the greatest number of asymmetric transformations through enamine, dienamine, and SOMO-activation strategies. Recently, trienamine catalysis, an extension of amine catalysis, has emerged as a powerful tool for synthetic chemists with a novel activation strategy for polyenals/polyenones. In this review article, we discuss the initial developments of trienamine catalysis for highly asymmetric Diels-Alder reactions with different dienophiles and emerging opportunities for other types of cycloadditions and cascade reactions.
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science-Pilani, Pilani Campus, 333 031 Rajasthan, India. indresh.chemistry@gmail.com
authors.forename: Indresh
authors.initials: I
authors.lastname: Kumar
authors.forename: Panduga
authors.initials: P
authors.lastname: Ramaraju
authors.forename: Nisar A
authors.initials: NA
authors.lastname: Mir
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D061565:Cycloaddition Reaction / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D000588:Amines