title: Successful management of a possible antibiotic-related acquired factor V inhibitor: a case report and review of the literature.
abstract: Acquired factor inhibitors are rare. We report a case of an elderly male who presented with a bleeding diathesis associated with an elevated prothrombin time and an activated partial thromboplastin time. Work-up revealed undetectable factor V activity and a factor V inhibitor level of >50 Bethesda units. The inhibitor may have been triggered by antibiotics. With a multimodality approach using steroids, platelet transfusions, intravenous immunoglobulin, factor VIII inhibitor bypass activity agent and cyclophosphamide, we successfully eliminated the inhibitor and controlled the bleeding.
authors.affiliation: Baystate Medical Center, Western Campus of Tuft’s University, School of Medicine, Springfield, MA 01107, USA. pooja.motwani@baystatehealth.org
authors.forename: Pooja
authors.initials: P
authors.lastname: Motwani
authors.forename: Leslie
authors.initials: L
authors.lastname: Howard
authors.forename: Syed S
authors.initials: SS
authors.lastname: Ali
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D005165:Factor V / Q000037:antagonists & inhibitors*; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced / Q000628:therapy; D006801:Humans; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D019774:Blood Coagulation Factor Inhibitors; D005165:Factor V