title: [The biological activity of the irritant dibenz-[b,f] - [1,4]-oxazepine (substance CR) persisting during a long period at the environmental objects].
abstract: The objective of the present study was to determine the biological activity of the irritant dibenz-[B,F]-[1,4]-oxazepine (substance CR) contained in the environmental samples in case of their "closed" storage during different periods of time. The experiments were carried out using male and female rabbits of the Chinchilla strain with the initial body mass of 3000-4000 g. The animals were administered an aqueous alcoholic extract from the tissue samples of the rabbit eye coat as described in the "Methodological guidelines on the medico-biological assessment of the safety of personal protection devices". The results of experiments indicate that extracts from tissue samples elicit irritation in the eyes of the laboratory animals even after their storage as long as 600 days. This observation suggests that substance CR retains the ability to cause irritation during a prolonged period.
authors.forename: A V
authors.initials: AV
authors.lastname: Kovalev
authors.forename: S I
authors.initials: SI
authors.lastname: Tolmachev
authors.forename: L A
authors.initials: LA
authors.lastname: Mukovskiĭ
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Khrustaleva
mesh_terms: D000818:Animals; D003989:Dibenzoxazepines / Q000737:chemistry / Q000633:toxicity*; D004355:Drug Stability; D004785:Environmental Pollutants / Q000737:chemistry / Q000633:toxicity*; D005123:Eye / Q000187:drug effects*; D005260:Female; D007509:Irritants / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D011817:Rabbits; D013665:Tear Gases / Q000737:chemistry / Q000633:toxicity*; D013784:Textiles; D013997:Time Factors
chemical_list: D003989:Dibenzoxazepines; D004785:Environmental Pollutants; D007509:Irritants; D013665:Tear Gases; C036433:dibenz(b,f)(1,4)oxazepine