title: Role of active surveillance in the management of localized prostate cancer.
abstract: Active surveillance is an increasingly recognized treatment option for men with low-risk prostate cancer. Despite encouraging evidence for oncologic efficacy and reduction in morbidity, several barriers contribute to the underuse of this management strategy. Consistent selection criteria as well as identification and validation of triggers for subsequent intervention are essential. Incorporation of novel biomarkers as well as advanced imaging techniques may improve surveillance strategies by better defining eligibility as well as improving prompt detection of disease progression.
authors.affiliation: Department of Urology, University of California-San Francisco, CA 94143-1695, USA. pcarroll@urology.ucsf.edu
authors.forename: Allison S
authors.initials: AS
authors.lastname: Glass
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Cooperberg
authors.forename: Maxwell V
authors.initials: MV
authors.lastname: Meng
authors.forename: Peter R
authors.initials: PR
authors.lastname: Carroll
mesh_terms: D014408:Biomarkers, Tumor; D019468:Disease Management; D018450:Disease Progression; D055088:Early Detection of Cancer; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D012306:Risk; D057832:Watchful Waiting
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen