title: [Clinical application of protein-to-creatinine ratio in spot urine samples for preeclampsia].
abstract: OBJECTIVE
  To evaluate the clinical application of protein-to-creatinine ratio (P/Cr) in spot urine samples so as to check whether it can replace urine protein excretion in 24 h collections for the diagnosis and screening of preeclampsia.
  
  
  METHODS
  The investigators selected 100 cases of pregnant women with preeclampsia and 36 cases of normal pregnant women examined at Sir Run Run Shaw Hospital over the last two years. The correlations between P/Cr in first morning urine samples and urinary protein excretion in 24 h collections were analyzed. The cutoff values of P/Cr in first morning urine samples for screening preeclampsia of 0.3 g and 5 g in urinary protein excretion in 24 h collections were determined by a receiver operating characteristics (ROC) curve.
  
  
  RESULTS
  A highly significant correlation existed between P/Cr in first morning urine samples and urinary protein excretion in 24 h collections. By the ROC curve analysis, the P/Cr of 0.34 g/g and 2.08 g/g in first morning urine samples represented the most appropriate threshold for detecting the urinary protein excretion of 0.3 g and 5 g in 24 h collections.
  
  
  CONCLUSIONS
  The P/Cr in spot urine samples can replace urinary protein excretion in 24 h collections. It is a simple and reliable tool of diagnosis and follow-up for preeclampsia.
authors.affiliation: Department of Obstetrics & Gynecology, Sir Run Run Shaw Hospital, Hangzhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Kuang
authors.forename: Feng-bing
authors.initials: FB
authors.lastname: Liang
authors.forename: Cui-yu
authors.initials: CY
authors.lastname: Yang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000652:urine*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000652:urine; D011507:Proteinuria / Q000652:urine*; D055815:Young Adult
chemical_list: D003404:Creatinine