title: Straightforward synthesis of a double-lasso macrocycle from a nonsymmetrical [c2]daisy chain.
abstract: The straightforward synthesis of a double-lasso macrocycle from a nonsymmetrical [c2]daisy chain, using the copper(I)-catalyzed Huisgen alkyne-azide 1,3-dipolar cycloaddition, is described. The preparation of the nonsymmetrical alkyne azide [c2]daisy chain precursor was realized in situ via the exchange of the monomers contained in both symmetrical alkyne and azide [c2]daisy chains and was followed by mass spectrometry.
authors.affiliation: Supramolecular Machines and Architecture Team, Institut des Biomolécules Max Mousseron, IBMM, UMR 5247 CNRS - UM1-UM2, Université Montpellier 2, Place Eugène Bataillon, case courrier 1706, F-34095 Montpellier Cedex 5, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Romuald
authors.forename: Guillaume
authors.initials: G
authors.lastname: Cazals
authors.forename: Christine
authors.initials: C
authors.lastname: Enjalbal
authors.forename: Frédéric
authors.initials: F
authors.lastname: Coutrot
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013058:Mass Spectrometry
chemical_list: D000480:Alkynes; D001386:Azides; D047028:Macrocyclic Compounds; D003300:Copper