title: Soluble HLA-G molecules and HLA-G 14-base pair polymorphism after allogeneic hematopoietic cell transplantation.
abstract: HLA-G 14-base pair (bp) polymorphism and soluble human leukocyte antigen G were previously reported to be implicated in allogeneic hematopoietic cell transplantation (allo-HSCT) outcome. However, soluble HLA-G blood levels and the 14-bp insertion-deletion polymorphism were separately assessed in the context of allo-HSCT. The aim of the present study was to examine the influence of the 14-bp insertion/deletion polymorphism of the HLA-G gene together with the soluble HLA-G plasma levels on allo-HSCT complications. We investigated the possible impact of HLA-G 14-bp polymorphism together with the pretransplantation and posttransplantation concentration of soluble HLA-G in 59 patients undergoing allo-HSCT. No association was found between the HLA-G 14-bp polymorphism, the soluble HLA-G level and acute graft-versus-host disease (GvHD), disease recurrence, or death. In contrast with previous reports the present data suggest a weak or negligible involvement of both 14-bp polymorphism on HLA-G gene and sHLA-G concentration in posttransplantation complications such as acute or chronic GvHD, relapse, or death.
authors.affiliation: Section of Allogeneic Stem Cell Transplantation, Department of Hematology/Oncology, University of Freiburg, Germany. miguel.waterhouse@uniklinik-freiburg.de
authors.forename: M
authors.initials: M
authors.lastname: Waterhouse
authors.forename: J
authors.initials: J
authors.lastname: Duque-Afonso
authors.forename: R
authors.initials: R
authors.lastname: Wäsch
authors.forename: H
authors.initials: H
authors.lastname: Bertz
authors.forename: J
authors.initials: J
authors.lastname: Finke
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D000368:Aged; D000483:Alleles; D018572:Disease-Free Survival; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005838:Genotype; D006086:Graft vs Host Disease; D059951:HLA-G Antigens / Q000097:blood* / Q000235:genetics*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000601:surgery; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000276:immunology / Q000601:surgery; D011110:Polymorphism, Genetic; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D020413:3' Untranslated Regions; D059951:HLA-G Antigens