title: Preoperative hormonal pattern in patients undergoing radical prostatectomy due to prostate cancer.
abstract: OBJECTIVE
  There is controversial evidence regarding preoperative testosterone (T) levels related to poor prognosis factors after radical prostatectomy (RP). The aim of this manuscript is to determine the relationship between preoperative T levels and final pathologic report together to biochemical recurrence after RP.
  
  
  METHODS
  We prospectively analysed 143 patients submitted to RP from February 2008 to June 2010 in our centre. Pretreatment T and sex hormone-binding globulin levels were determined as part of our clinical protocol. Free calculated (fT) and bioavailable (bioT) T were calculated using Vermeulen's formula. Low T levels were defined as 346 ng/dL or less. A comparative analysis with variables pTNM, positive margins, tumour burden, Gleason score, multifocality and biochemical recurrence (using both PSA>0.4 ng/dL and PSA>0.2 ng/dL as cut-off values) was performed, according to preoperative levels of T.
  
  
  RESULTS
  Variables Gleason score, rate and number of positive margins, tumour burden, tumour multifocality, time to biochemical recurrence and pathological stage were not related to preoperative hormonal levels. Preoperative T<346 ng/dL was not found to be related to PSA recurrence (PSA>0,4 ng/dL log-rank, P=.512), although a trend was observed when PSA>0,2 ng/dL (log-rank, P=.097).
  
  
  CONCLUSIONS
  Preoperative T levels were not related to final pathological report or to biochemical recurrence.
authors.affiliation: Departamento de Urología, Hospital Clínic, Barcelona, España. Electronic address: edu_garcia_cruz@yahoo.com.
authors.forename: E
authors.initials: E
authors.lastname: García-Cruz
authors.forename: R
authors.initials: R
authors.lastname: Castañeda-Argáiz
authors.forename: A
authors.initials: A
authors.lastname: Carrión
authors.forename: J
authors.initials: J
authors.lastname: Alcover
authors.forename: A
authors.initials: A
authors.lastname: Sallent
authors.forename: A
authors.initials: A
authors.lastname: Leibar-Tamayo
authors.forename: J
authors.initials: J
authors.lastname: Romero-Otero
authors.forename: A
authors.initials: A
authors.lastname: Alcaraz
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology / Q000601:surgery; D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009376:Neoplasms, Hormone-Dependent / Q000097:blood* / Q000473:pathology / Q000601:surgery; D011300:Preoperative Care; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone / Q000097:blood*; D047368:Tumor Burden
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D017430:Prostate-Specific Antigen