title: Nonhealing ulcer: acroangiodermatitis of mali.
abstract: An 18-year-old male presented with a nonhealing wound on left lower limb, pain and swelling over multiple joints, weight loss, and yellowish discoloration of eyes and urine for the past 4 years. On examination, the patient had pallor, icterus, and generalized lymphadenopathy with a nonhealing unhealthy ulcer over left medial malleolus. He had deformed joints with hepatomegaly and splenomegaly. His laboratory investigations were positive for antinuclear antibody (ANA) and anticardiolipin antibody (ACLA). Synovial fluid analysis showed inflammatory findings. Biopsy of margin of the ulcer showed findings consistent with Acroangiodermatitis of Mali. The patient was treated with disease-modifying antirheumatic drugs (DMARDs) and aspirin for juvenile idiopathic arthritis and secondary antiphospholipid antibody syndrome (APS), respectively. The ulcer was managed conservatively with systemic antibiotics and topical steroids along with limb elevation and compression elastic stockings. The patient's symptoms improved significantly, and he is in our followup.
authors.affiliation: Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi 221005, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Varyani
authors.forename: Anubhav
authors.initials: A
authors.lastname: Thukral
authors.forename: Nilesh
authors.initials: N
authors.lastname: Kumar
authors.forename: Kailash Kumar
authors.initials: KK
authors.lastname: Gupta
authors.forename: Ravi
authors.initials: R
authors.lastname: Tandon
authors.forename: Kamlakar
authors.initials: K
authors.lastname: Tripathi