title: Mast cell tumors in cats: clinical update and possible new treatment avenues.
abstract: BACKGROUND
  Feline mast cell tumors (MCTs) are frequently encountered in general practice. MCTs are the most common splenic tumor, second most common skin tumor and third most common intestinal tumor in cats. Treatment and prognosis can vary dramatically with location and histologic classification.
  
  
  OBJECTIVE
  While a cytologic or histologic diagnosis is often easy to obtain, the various histologic classifications, lack of a relevant grading scheme, and disparity in behavior depending on anatomic location make prognostication for cases of feline MCTs confusing. This is quite different from canine MCTs, where there is an established grading system which correlates clinically with prognosis and an accepted standard of care.
  
  
  BACKGROUND
  Due to its prevalence, general practitioners encounter MCTs regularly. In many instances, referral for diagnosis and treatment is not necessary.
  
  
  METHODS
  Historically, there has been limited clinical evidence upon which to determine optimal treatment of MCTs in cats. Most recommendations are based on limited case reports or retrospective studies. With the recent introduction of receptor tyrosine kinase inhibitors to the veterinary market, there has been new research on the use of these drugs in cats, and new treatment options are on the horizon.
authors.affiliation: University of Missouri, Columbia, MO 65211, USA. HenryC@missouri.edu
authors.forename: Carolyn
authors.initials: C
authors.lastname: Henry
authors.forename: Chamisa
authors.initials: C
authors.lastname: Herrera
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002371:Cat Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D002415:Cats; D004285:Dogs; D005260:Female; D012515:Mast-Cell Sarcoma / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D009367:Neoplasm Staging / Q000662:veterinary; D011379:Prognosis; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D016019:Survival Analysis; D016896:Treatment Outcome; D014730:Veterinary Medicine
chemical_list: D000970:Antineoplastic Agents