title: [Mechanism of action for immunotherapy drugs].
abstract: Cancer therapy utilizing cellular immunity has been developed using various reagents including stimulus for innate immunity, cytokines, vaccines, autologous cells and gene-vectors. Recently, mono-clonal antibodies have been added to the list as well. These reagents of modalities have been developed base on the findings in the basic research in cellular immunology which has been proven to have potent activities to suppress the tumor growth in either in vitro or in vivo. This review describes the characteristics of the reagents of modalities focusing on their mechanisms of action.
authors.affiliation: Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Tahara
mesh_terms: D000970:Antineoplastic Agents / Q000276:immunology / Q000627:therapeutic use*; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D019496:Cancer Vaccines; D016207:Cytokines