title: Prospective memory performance in patients with drug-naïve, first-episode psychosis.
abstract: Schizophrenia is associated with an impairment of prospective memory (PM) which refers to the ability to remember to carry out an intended action in the future. However, most of these studies were limited to chronic samples. The current study examined the event-based PM and time-based PM using a dual-task paradigm in 22 drug-naïve, first-episode psychosis (FEP) patients and 23 healthy controls. Results indicated that FEP patients performed significantly poorer than healthy controls in both event-based and time-based PM. However, the significant difference in time-based PM disappeared after controlling for working memory. Correlation analysis indicated that both types of PM did not correlate with positive symptoms or negative symptoms, duration of illness, or duration of untreated psychosis. However, time-based PM was correlated with the general psychopathology subscale of the PANSS. Taken together, these findings suggest that PM deficits are present in drug-naïve FEP patients; impairment of event-based PM appears to occur independently, whereas time-based PM impairment may be, in part, a secondary consequence of a working memory deficit.
authors.affiliation: Schizophrenia Program, Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Kaiming
authors.initials: K
authors.lastname: Zhuo
authors.forename: Yun
authors.initials: Y
authors.lastname: Lu
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Yang
authors.forename: Xiaoduo
authors.initials: X
authors.lastname: Fan
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Song
authors.forename: Liwei
authors.initials: L
authors.lastname: Liao
authors.forename: Chenfeng
authors.initials: C
authors.lastname: Ji
authors.forename: Dianming
authors.initials: D
authors.lastname: Zhu
authors.forename: Shunying
authors.initials: S
authors.lastname: Yu
authors.forename: Chao
authors.initials: C
authors.lastname: Yan
authors.forename: Raymond C K
authors.initials: RC
authors.lastname: Chan
authors.forename: Donald C
authors.initials: DC
authors.lastname: Goff
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Xu
authors.forename: Dengtang
authors.initials: D
authors.lastname: Liu
mesh_terms: D006801:Humans; D008569:Memory Disorders / Q000503:physiopathology* / Q000523:psychology; D061212:Memory, Episodic; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013997:Time Factors