title: Chemical biology based on target-selective degradation of proteins and carbohydrates using light-activatable organic molecules.
abstract: Proteins and carbohydrates play crucial roles in a wide range of biological processes, including serious diseases. The development of novel and innovative methods for selective control of specific proteins and carbohydrates functions has attracted much attention in the field of chemical biology. In this account article, the development of novel chemical tools, which can degrade target proteins and carbohydrates by irradiation with a specific wavelength of light under mild conditions without any additives, is introduced. This novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of proteins and carbohydrates but also novel therapeutic drugs targeting proteins and carbohydrates.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan. toshima@applc.keio.ac.jp
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Toshima
mesh_terms: D050260:Carbohydrate Metabolism / Q000528:radiation effects; D002241:Carbohydrates / Q000737:chemistry*; D008027:Light; D008956:Models, Chemical; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D059748:Proteolysis / Q000528:radiation effects
chemical_list: D002241:Carbohydrates; D009930:Organic Chemicals; D011506:Proteins