title: Defining "poor mobilizer" in pediatric patients who need an autologous peripheral blood progenitor cell transplantation.
abstract: The definition of poor mobilizers is not clear in pediatric patients undergoing autologous peripheral blood hematopoietic progenitor cell (HPC) mobilization. Most studies conducted in children define those variables related to the collection of HPC after leukapheresis, but the information regarding exclusively the mobilization process is scarce. In our experience, most children (92.2%) reach the target CD34(+) cell dose for autologous peripheral blood progenitor cell transplantation if CD34(+) cell count was higher than 10/μL. No differences were observed between those with >20 CD34(+) cells/μL and 11-20 CD34(+) cells/μL. In this study, we analyzed the variables that influence CD34(+) cell count; we found that prior use of radiotherapy was the main variable related to poor mobilization. Patients diagnosed with Ewing sarcoma, treated with radiotherapy and mobilized with standard doses of granulocyte colony-stimulating factor (G-CSF) were also at a high risk of mobilization failure. In these patients, we should consider mobilization with high dose G-CSF and be prepared with new mobilization agents to avoid delay on their course of chemotherapy.
authors.affiliation: Servicio de Hemato-Oncología, Hospital Infantil Universitario Niño Jesús, Madrid, Spain. jsevilla.hnjs@salud.madrid.org
authors.forename: Julián
authors.initials: J
authors.lastname: Sevilla
authors.forename: María
authors.initials: M
authors.lastname: Guillén
authors.forename: Ana
authors.initials: A
authors.lastname: Castillo
authors.forename: Marta
authors.initials: M
authors.lastname: Prudencio
authors.forename: Marta
authors.initials: M
authors.lastname: González-Vicent
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Lassaletta
authors.forename: María
authors.initials: M
authors.lastname: Cormenzana
authors.forename: Manuel
authors.initials: M
authors.lastname: Ramírez
authors.forename: Antonio
authors.initials: A
authors.lastname: Pérez-Martínez
authors.forename: Luis
authors.initials: L
authors.lastname: Madero
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Díaz-Pérez
mesh_terms: D000293:Adolescent; D018952:Antigens, CD34 / Q000378:metabolism; D002648:Child; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D018952:Antigens, CD34; D016179:Granulocyte Colony-Stimulating Factor