title: [Expression of Th17 related cell factors and its significance in CRSsNP].
abstract: OBJECTIVE
  To detect the expression of Th17 nuclear factor RORC and cytokines IL-17A and IL-22 and neutrophil marker MPO and their correlations with CRSsNP.
  
  
  METHODS
  RT-PCR was used to detect mRNA expression of RORC, IL-17A and IL-22. Immunohistochemistry was used to assess the IL-17A positive cells in CRSsNP and control. ELISA was used to detect the expression of MPO.
  
  
  RESULTS
  CRSsNP had higher mRNA expression of RORC, IL-17A and IL-22 and increased protein expression of MPO. The mRNA expression of RORC, IL-17A and IL-22 was positively correlated with each other but none of them was correlated with the expression of MPO in CRSsNP and control.
  
  
  CONCLUSIONS
  Both Th17 and neutrophils contribute to the pathogenesis of CRSsNP, however, the neutrophil infiltration may not be recruited by Th17 cytokines.
authors.affiliation: Department of Otorhinolaryngology, Puai Hospital, Wuhan,430034, China.
authors.forename: Baofeng
authors.initials: B
authors.lastname: Wang
authors.forename: Bennong
authors.initials: B
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Cao
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.forename: Yanni
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology; D007378:Interleukins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020556:Neutrophil Infiltration; D009504:Neutrophils / Q000276:immunology*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000276:immunology; D012852:Sinusitis / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*; D000097043:Interleukin-22
chemical_list: D020381:Interleukin-17; D007378:Interleukins; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D000097043:Interleukin-22; C539900:RORC protein, human