title: Reduction of dependence to cannabinoids by GLT-1 activating property of the beta-lactam antibiotic.
abstract: Since GLT-1 transporters play the key role in terminating synaptic transmission of glutamate, drugs stimulating GLT-1 expression are expected to offer neuroprotection. Of these, beta-lactam antibiotics have been suggested to contribute to various central nervous system disorders, including development of tolerance and dependence to opioids, and tolerance to cannabinoids. Opioids and cannabinoids share many pharmacological properties. All together, it can be hypothesized that beta-lactam antibiotics may reduce the development of dependence to cannabinoids through activating GLT-1.
authors.affiliation: Department of Medical Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey. aulugol@trakya.edu.tr
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ulugol
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002186:Cannabinoids / Q000009:adverse effects*; D027342:Excitatory Amino Acid Transporter 2 / Q000378:metabolism*; D007769:Lactams / Q000494:pharmacology*; D013375:Substance Withdrawal Syndrome
chemical_list: D000900:Anti-Bacterial Agents; D002186:Cannabinoids; D027342:Excitatory Amino Acid Transporter 2; D007769:Lactams