title: Gas-phase ion/ion reactions of peptides and proteins: acid/base, redox, and covalent chemistries.
abstract: Gas-phase ion/ion reactions are emerging as useful and flexible means for the manipulation and characterization of peptide and protein biopolymers. Acid/base-like chemical reactions (i.e., proton transfer reactions) and reduction/oxidation (redox) reactions (i.e., electron transfer reactions) represent relatively mature classes of gas-phase chemical reactions. Even so, especially in regards to redox chemistry, the widespread utility of these two types of chemistries is undergoing rapid growth and development. Additionally, a relatively new class of gas-phase ion/ion transformations is emerging which involves the selective formation of functional-group-specific covalent bonds. This feature details our current work and perspective on the developments and current capabilities of these three areas of ion/ion chemistry with an eye towards possible future directions of the field.
authors.affiliation: Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN 47907-2084, USA.
authors.forename: Boone M
authors.initials: BM
authors.lastname: Prentice
authors.forename: Scott A
authors.initials: SA
authors.lastname: McLuckey
mesh_terms: D005740:Gases / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D011522:Protons
chemical_list: D005740:Gases; D007477:Ions; D010455:Peptides; D011506:Proteins; D011522:Protons