title: Retinal oximetry using ultrahigh-resolution optical coherence tomography.
abstract: BACKGROUND
  The purpose of this study was to investigate the repeatability of retinal oximetry using slit-lamp adapted ultrahigh-resolution optical coherence tomography (SL-UHR-OCT).
  
  
  METHODS
  SL-UHR-OCT was developed and fringe patterns were obtained for a major retinal artery and a major retinal vein. A-scans at the central wavelengths of 805 nm and 855 nm were analyzed for calculating optical density ratios (ODRs), from which the percentage oxygen saturation was calculated. Measurements were made on two occasions for each person. Repeatability and coefficients of repeatability were calculated.
  
  
  RESULTS
  The mean ODRs of the artery were 0.79 ± 0.86 and 0.88 ± 0.97 in sessions 1 and 2, respectively. The mean ODRs of the vein were -0.08 ± 0.69 and 0.14 ± 0.77 between the two sessions, and were significantly lower than that of the artery (P < 0.05). The coefficients of repeatability were 1.44 and 1.81 for the artery and vein, respectively. The mean oxygen saturation of the major retinal artery was 94% ± 45% and 98% ± 51% in sessions 1 and 2, respectively, and the mean oxygen saturation of the major retinal vein was 48% ± 36% and 60% ± 40% between sessions.
  
  
  CONCLUSIONS
  Optical coherence tomographic oximetry for evaluating retinal oxygen saturation was subject to variation, although the averaged measurements in repeated sessions were matched. Further work on reducing variation will be needed.
authors.affiliation: Hangzhou First People's Hospital, Hangzhou, China ; Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Ye
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Meixiao
authors.initials: M
authors.lastname: Shen
authors.forename: Byron L
authors.initials: BL
authors.lastname: Lam
authors.forename: Delia Cabrera
authors.initials: DC
authors.lastname: Debuc
authors.forename: Lili
authors.initials: L
authors.lastname: Ge
authors.forename: Mitra
authors.initials: M
authors.lastname: Sehi
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wang