title: Children's Oncology Group's 2013 blueprint for research: cancer control and supportive care.
abstract: In cancer control research, the objective is to reduce overall morbidity and mortality by decreasing acute and delayed treatment-related toxicities in all children with cancer. To date, the Children's Oncology Group (COG) has focused on infection, neurocognition, quality of life (QoL), and nutrition/antiemetics. COG is conducting randomized controlled trials (RCTs) to determine prophylaxis strategies that will reduce infections in high-risk populations. Two RCTs are determining if modafinil or computerized cognitive training improve cognitive functioning in pediatric brain tumor patients. QoL is being assessed in acute leukemia patients. Improved supportive care outcomes will only occur when the most effective interventions are established.
authors.affiliation: Department of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. lillian.sung@sickkids.ca
authors.forename: Lillian
authors.initials: L
authors.lastname: Sung
authors.forename: Theo
authors.initials: T
authors.lastname: Zaoutis
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: Ullrich
authors.forename: Donna
authors.initials: D
authors.lastname: Johnston
authors.forename: Lee
authors.initials: L
authors.lastname: Dupuis
authors.forename: Elena
authors.initials: E
authors.lastname: Ladas
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002986:Clinical Trials as Topic; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control; D003695:Delivery of Health Care; D006801:Humans; D007239:Infections / Q000209:etiology; D009369:Neoplasms / Q000150:complications* / Q000628:therapy; D011788:Quality of Life; D011878:Radiotherapy / Q000009:adverse effects*; D012106:Research
chemical_list: D000970:Antineoplastic Agents