title: Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.
abstract: Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non peptidic PAD4 inhibitors incorporating primary/secondary guanidine moieties.
authors.affiliation: Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.
authors.forename: Murat
authors.initials: M
authors.lastname: Bozdag
authors.forename: Tobias
authors.initials: T
authors.lastname: Dreker
authors.forename: Christophe
authors.initials: C
authors.lastname: Henry
authors.forename: Paolo
authors.initials: P
authors.lastname: Tosco
authors.forename: Maura
authors.initials: M
authors.lastname: Vallaro
authors.forename: Roberta
authors.initials: R
authors.lastname: Fruttero
authors.forename: Andrea
authors.initials: A
authors.lastname: Scozzafava
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Carta
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006147:Guanine / Q000737:chemistry; D006801:Humans; D006867:Hydrolases / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D015394:Molecular Structure; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases
chemical_list: D004791:Enzyme Inhibitors; D006147:Guanine; D006867:Hydrolases; C000629235:PADI4 protein, human; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases