title: Preparation of magnetic molecularly imprinted polymers for bisphenol A and its analogues and their application to the assay of bisphenol A in river water.
abstract: Magnetic molecularly imprinted polymers (M-MIPs) for bisphenol A (BPA) and its structural analogues have been prepared by a multi-step swelling and polymerization method using uniformly-sized magnetic particles as a shape template. Binding experiments and Scatchard analyses revealed that two classes of binding sites were formed on M-MIP(BPA). The retention and molecular-recognition properties of M-MIPs for BPA and its structural analogues were evaluated using a mixture of phosphate buffer and acetonitrile or a mixture of water and acetonitrile as a mobile phase by LC. M-MIPs for BPA and [²H₁₆]BPA (BPA-d₁₆), M-MIP(BPA) and M-MIP(BPA-d16), showed almost the same imprinting factors for BPA, while M-MIP for bisphenol B (2,2-bis(4-hydroxyphenyl)butane, BPB), M-MIP(BPB), gave the moderate imprinting factor for BPA. Furthermore, M-MIP(BPB) was applied for the selective extraction and determination of BPA in environmental water samples. The concentration of BPA in river water samples was determined to be 68 ng/L.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo 663-8179, Japan.
authors.forename: Yuma
authors.initials: Y
authors.lastname: Hiratsuka
authors.forename: Noriko
authors.initials: N
authors.lastname: Funaya
authors.forename: Hisami
authors.initials: H
authors.lastname: Matsunaga
authors.forename: Jun
authors.initials: J
authors.lastname: Haginaka
mesh_terms: D001559:Benzhydryl Compounds / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D052244:Endocrine Disruptors / Q000032:analysis* / Q000737:chemistry; D004784:Environmental Monitoring / Q000379:methods*; D004968:Estrogens, Non-Steroidal / Q000032:analysis* / Q000737:chemistry; D005618:Fresh Water / Q000737:chemistry*; D007564:Japan; D007700:Kinetics; D060328:Magnetic Phenomena; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D054802:Molecular Imprinting; D010636:Phenols / Q000032:analysis* / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D045483:Rivers; D013499:Surface Properties; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000737:chemistry; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D011108:Polymers; D014874:Water Pollutants, Chemical; C006780:bisphenol A; D000098826:Bisphenol A Compounds