title: Group A rotavirus universal mass vaccination: how and to what extent will selective pressure influence prevalence of rotavirus genotypes?
abstract: Two human group A rotavirus (RVA) vaccines are available and highly effective in preventing severe gastroenteritis caused by all commonly circulating human RVA genotypes. The effect of universal mass vaccination on the RVA genotype distribution is discussed based on the knowledge of complete RVA genotype constellations, data from clinical efficacy trials and effectiveness studies, and genotype surveillance data from countries with universal mass vaccination programs. The theoretically predicted relative enrichment of RVA strains with the G2P[4] DS-1-like genotype constellation in regions with high coverage by Rotarix(®) (GlaxoSmithKline Biologicals, Rixensart, Belgium) seems to become apparent. A G3P[8] genotype increase, which was noted in several regions with a high coverage of RotaTeq(®) (Merck and Co., Inc., NJ, USA), is more difficult to explain based on the theoretical considerations.
authors.affiliation: Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
authors.forename: Jelle
authors.initials: J
authors.lastname: Matthijnssens
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakagomi
authors.forename: Carl D
authors.initials: CD
authors.lastname: Kirkwood
authors.forename: Max
authors.initials: M
authors.lastname: Ciarlet
authors.forename: Ulrich
authors.initials: U
authors.lastname: Desselberger
authors.forename: Marc
authors.initials: M
authors.lastname: Van Ranst
mesh_terms: D005838:Genotype; D006801:Humans; D032541:Mass Vaccination / Q000379:methods*; D017720:Molecular Epidemiology; D012401:Rotavirus / Q000145:classification* / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D012641:Selection, Genetic
chemical_list: D022243:Rotavirus Vaccines