title: [The role of TGF-beta activation on different pathological phenotypes in chronic rhinosinusitis].
abstract: Transforming growth factor-beta (TGF-beta) as a main switch has a crucial role in chronic rhinosinusitis (CRS) subtypes. The physiological functions of the secreted inactive TGF-beta are precisely regulated by suppressing factors, such as latency-associated peptide (LAP), latent TGF-beta-binding protein (LTBP) and fibrillin, as well as activating factors, such as integrins, proteases and thrombospondin-1. With progress in understanding the factors responsible for regulating TGF-beta functions, it has been revealed that the dysregulation of TGF-beta activation is closely associated with lung fibrosis and chronic obstructive pulmonary disease. Since the imbalance between TGF beta-regulating factors may be one of the main reasons for different phenotypes of CRS, we reviewed the advancement in the research of TGF-beta activation and its role in CRS pathogenesis, to provide insight into the CRS investigation in human.
authors.forename: Jinyin
authors.initials: J
authors.lastname: Xiang
authors.forename: Ji
authors.initials: J
authors.lastname: Shen
authors.forename: Suling
authors.initials: S
authors.lastname: Hong
mesh_terms: D002908:Chronic Disease; D006801:Humans; D053779:Latent TGF-beta Binding Proteins / Q000378:metabolism; D011485:Protein Binding; D012220:Rhinitis / Q000378:metabolism / Q000473:pathology*; D012852:Sinusitis / Q000378:metabolism / Q000473:pathology*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D053779:Latent TGF-beta Binding Proteins; D016212:Transforming Growth Factor beta