title: Soft tissue angiofibroma: report of 2 cases of a recently described tumor.
abstract: Several soft tissue tumors are characterized by fibrous stroma with a conspicuous vascular component including cellular angiofibroma, nasopharyngeal angiofibroma, and solitary fibrous tumor. Recently, a distinctive fibroblastic tumor composed of bland spindle cells and a complex vascular network has been characterized morphologically and shown to harbor a recurrent t(5;8) translocation with AHRR-NCOA2 gene fusion. We report our recent experience with 2 examples of this benign tumor, the diagnosis for one of which was supported by fluorescence in situ hybridization for NCOA2 rearrangement. Identification of this tumor is important to prevent misdiagnosis as a low-grade sarcoma.
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. medgar@emory.edu
authors.forename: Mark A
authors.initials: MA
authors.lastname: Edgar
authors.forename: Scott R
authors.initials: SR
authors.lastname: Lauer
authors.forename: Julia A
authors.initials: JA
authors.lastname: Bridge
authors.forename: Monica
authors.initials: M
authors.lastname: Rizzo
mesh_terms: D000368:Aged; D018322:Angiofibroma / Q000235:genetics / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000235:genetics*; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D051958:Nuclear Receptor Coactivator 2 / Q000235:genetics*; D016612:Paraffin Embedding; D012509:Sarcoma / Q000235:genetics / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000473:pathology*; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; C498001:NCOA2 protein, human; D051958:Nuclear Receptor Coactivator 2