title: The long-term risk of continuous immunosuppression using thioguanides in inflammatory bowel disease.
abstract: The efficacy of thiopurine treatment in the induction, and especially maintenance, of remission in inflammatory bowel disease is well proven; however, it is associated with side effects in both medium and long-term use. The potential harmful effects may be anticipated and minimised by due diligence prior to commencing these drugs followed by close monitoring of haematological and biochemical parameters once started. Careful clinical examination and history taking are also essential. Affected patients are expected to lead lives that include travel, employment and pregnancy - the implications of continued thiopurine therapy in such patients are discussed.
authors.affiliation: Dr Asghar Qasim Prof. Colm A. O'Moráin Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland.
authors.forename: Anthony
authors.initials: A
authors.lastname: O'Connor
authors.forename: Asghar
authors.initials: A
authors.lastname: Qasim
authors.forename: Colm A
authors.initials: CA
authors.lastname: O'Moráin