title: Oxytocin inhibits pentylentetrazol-induced seizures in the rat.
abstract: We aimed to reveal the anti-convulsant effects of oxytocin (OT) in pentylenetetrazol (PTZ)-induced seizures in rats. Thirty rats were randomly divided into 5 equal groups. Using stereotaxy, we implanted electroencephologram (EEG) electrodes in the left nucleus of the posterior thalamus. After 2 days, the first and second groups were used as the control and PTZ (35 mg/kg) groups, respectively. We administered 40, 80 and 160 nmol/kg OT+35 mg/kg PTZ to the rats, constituting the third, fourth, and fifth groups, respectively, for 5 days. At the end of 5 days, we recorded EEGs via bipolar EEG electrodes. After 12h, all groups except the first received 70 mg/kg PTZ and we determined the dose-response ratio. Racine's Convulsion Scale was used to evaluate seizures. The spike-wave complex percentage in the EEG was determined as 0% for the first group, 38.6%±7.2 for the second group, 36.4%±5.6 for the third group, 4.3%±1.8 for the fifth group and 4.1%±1.1 for the fifth group. The fourth and fifth groups had significantly decreased spike-wave complex percentages compared to the second group (p<0.0001). OT may prevent PTZ-induced epilepsy on an EEG. OT may also be considered for use in the treatment of epilepsy in the future.
authors.affiliation: Ege University Faculty of Medicine, Department of Physiology, Izmir, Turkey.
authors.forename: Oytun
authors.initials: O
authors.lastname: Erbas
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yılmaz
authors.forename: Huseyin Anil
authors.initials: HA
authors.lastname: Korkmaz
authors.forename: Saylav
authors.initials: S
authors.lastname: Bora
authors.forename: Vedat
authors.initials: V
authors.lastname: Evren
authors.forename: Gonul
authors.initials: G
authors.lastname: Peker
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D010121:Oxytocin / Q000008:administration & dosage*; D010433:Pentylenetetrazole / Q000633:toxicity; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
chemical_list: D010121:Oxytocin; D010433:Pentylenetetrazole