title: Platelet hyperreactivity: report of a case with catastrophic arterial thrombosis in a child.
abstract: Platelet hyperreactivity is an important but under-recognized cause of idiopathic arterial thrombosis. We describe a case of arterial thrombosis in a previously healthy 12-year-old girl after minor trauma to the knee, resulting in lower extremity amputation. Family history was positive for arterial and venous thrombosis, but an extensive work-up for the usual inherited thrombophilia risk factors was negative. The patient was eventually diagnosed with platelet hyperreactivity and remains on life-long antiplatelet therapy.Consideration of platelet hyperreactivity in the evaluation of unusual arterial thrombotic events allows for targeted therapy, potential avoidance of future events, and timely screening of family members.
authors.affiliation: Department of Pathology, The Ohio State University, Columbus, OH, USA.
authors.forename: Elizabeth F
authors.initials: EF
authors.lastname: Plocharczyk
authors.forename: Sarah H
authors.initials: SH
authors.lastname: O'Brien
authors.forename: Jill L
authors.initials: JL
authors.lastname: Crumbacher
authors.forename: Samir B
authors.initials: SB
authors.lastname: Kahwash
mesh_terms: D000671:Amputation, Surgical; D001792:Blood Platelets / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply / Q000473:pathology / Q000601:surgery; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012307:Risk Factors; D019851:Thrombophilia / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013927:Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery
chemical_list: D010975:Platelet Aggregation Inhibitors