title: Recurrent fevers.
abstract: An 11-year-old girl had four episodes of fever in a year, lasting 7-10 days and associated with headache and neck stiffness. She had a long history of recurrent urticaria, usually preceding the fevers. There was also a history of vague pains in her knees and in the small joints of her hands. Her serum C-reactive protein was moderately raised at 41 g/L (normal <8). Her rheumatologist felt the association of recurrent fevers that lasted 7 or more days with headaches, arthralgia and recurrent urticaria suggested one of the periodic fever syndromes. Genetic testing confirmed she had a gene mutation consistent with one of tumour necrosis factor receptor-associated periodic syndrome.
authors.affiliation: The Children's Hospital at Westmead, Westmead, New South Wales, Australia. davidi@chw.edu.au
authors.forename: David
authors.initials: D
authors.lastname: Isaacs
authors.forename: Alison
authors.initials: A
authors.lastname: Kesson
authors.forename: David
authors.initials: D
authors.lastname: Lester-Smith
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Chaitow
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D056660:Hereditary Autoinflammatory Diseases / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D009154:Mutation; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics*
chemical_list: D018124:Receptors, Tumor Necrosis Factor