title: [Fluoropyrimidines with oxaliplatin(L-OHP) as an adjuvant chemotherapy for Stage III colon cancer].
abstract: As an adjuvant treatment for Dukes B2 and C colon cancer, adding oxaliplatin (L-OHP) to a regimen of fluorouracil and Leucovorin improved disease-free survival in Western countries. In Japan, however, adjuvant chemotherapy with L-OHP is not commonly used to treat Stage III colon cancer. We report the present condition of adjuvant treatment for colon cancer in our hospital. Between September 2009 and December 2011, 66 patients with Stage III colon cancer were enrolled after curative surgery. The details of adjuvant therapy with fluoropyrimidines with and without L-OHP were explained to the patients. After the explanation, 33.3% of the patients(IIIa: 18.9%, IIIb: 55.5%) selected L-OHP chemotherapy. Regardless of the side effects, adjuvant chemotherapy including L-OHP is expected to protect against cancer recurrence in patients with Stage IIIb colon cancer.
authors.affiliation: Dept. of Surgery, Minoh City Hospital Gastrointestinal Research Center, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miyake
authors.forename: Kimimasa
authors.initials: K
authors.lastname: Ikeda
authors.forename: Hideki
authors.initials: H
authors.lastname: Osawa
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Nagase
authors.forename: Minako
authors.initials: M
authors.lastname: Hoshi
authors.forename: Takashi
authors.initials: T
authors.lastname: Doi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Makari
authors.forename: Satoshi
authors.initials: S
authors.lastname: Oshima
authors.forename: Shohei
authors.initials: S
authors.lastname: Iijima
authors.forename: Eiji
authors.initials: E
authors.lastname: Kurokawa
authors.forename: Nobuteru
authors.initials: N
authors.lastname: Kikkawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects; D000077150:Oxaliplatin
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D005472:Fluorouracil