title: [Beta-glucan as a natural anticancer agent].
abstract: Beta-glucans participate in the processes of repair, metabolism and detoxification, and affect the overall health of the body counteract the pathological conditions of reactive oxygen and nitrogen and the processes in which they participate. Reactive oxygen species (ROS) and nitrogen (RNS) play an important role in the pathogenesis of many diseases. Production of ROS is an integral part of aerobic metabolism of cells. Physiological concentrations of ROS play an important role in proper functioning of many cellular processes, and their overproduction occurs during induced oxidative stress. Very closely associated with oxidative stress is nitrosative stress. Nitric oxide (NO) reacts with molecular oxygen, superoxide anion radical and metal cations to give more reactive oxygen species. Reactive oxygen and nitrogen react with proteins to cause impairment of their function by oxidation or nitrosylation of amino acid residues, which can direct the path of apoptotic cells. In addition, nitric oxide enhances the effect induced by cyclooxygenase and becomes a mediator of inflammation.
authors.affiliation: Wroclaw University of Environmental and Life Scinces, Poland, Department of Food Storage and Technology.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Jurczyńska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Saczko
authors.forename: Julita
authors.initials: J
authors.lastname: Kulbacka
authors.forename: Joanna
authors.initials: J
authors.lastname: Kawa-Rygielska
authors.forename: Józef
authors.initials: J
authors.lastname: Błazewicz
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000517:prevention & control*; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D026361:Reactive Nitrogen Species / Q000096:biosynthesis*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013481:Superoxides; D047071:beta-Glucans / Q000378:metabolism*
chemical_list: D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D047071:beta-Glucans; D013481:Superoxides; D009569:Nitric Oxide