title: Effects of Helicobacter pylori infection on MUC5AC protein expression in gastric cancer.
abstract: OBJECTIVE
  To investigate the effects of the expression of the MUC5AC protein in gastric cancer depending on the Helicobacter pylori (Hp) infection status.
  
  
  METHODS
  The MUC5AC protein and mRNA were detected using western blot and real-time PCR protocols in gastric cancer tissue and stratified for Hp infection. Gastric mucus membranes near the cancer site serve as the control group.
  
  
  RESULTS
  The expression of MUC5AC protein and mRNA is significantly decreased in gastric cancer tissue (p < 0.05). The decrease was more significant in the Hp-infected group than in the Hp-uninfected group (p < 0.05).
  
  
  CONCLUSIONS
  The infection of Hp is correlated with a decrease in MUC5AC protein amount in gastric cancer tissue. The current result suggests that there may be a potential necessary link between Hp, MUC5AC and gastric cancer.
authors.affiliation: Department of Gastroenterology, The First People's Hospital of Yuhang District, Hangzhou 311100, Zhejiang Province, China. shidingyuhang@163.com
authors.forename: Ding
authors.initials: D
authors.lastname: Shi
authors.forename: Xin-min
authors.initials: XM
authors.lastname: Qiu
authors.forename: Yin-feng
authors.initials: YF
authors.lastname: Bao
mesh_terms: D016481:Helicobacter Infections / Q000378:metabolism* / Q000382:microbiology*; D016480:Helicobacter pylori; D006801:Humans; D055271:Mucin 5AC / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000382:microbiology*
chemical_list: C524678:MUC5AC protein, human; D055271:Mucin 5AC; D012333:RNA, Messenger