title: [Four cases of meningeal metastasis originating from breast cancer].
abstract: Carcinomatous meningitis due to breast cancer is comparatively rare in Japan. Here, we report 4 cases of carcinomatous meningitis due to breast cancer. Meningeal metastasis was present in only 1 of the 4 cases, and the other 3 cases were associated with brain metastasis. Meningeal metastasis frequently causes symptoms associated with intracranial hypertension. Gadolinium-enhanced magnetic resonance imaging and cerebrospinal fluid cytology were useful for the diagnosis of meningeal metastasis. Multidisciplinary therapy, such as radiation and chemotherapy, was performed. Two of the 4 patients were treated with combined intrathecal administration of methotrexate and whole brain radiation. The quality of life was improved by multidisciplinary therapy.
authors.affiliation: Dept. of Surgical Oncology, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kashiwagi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Asano
authors.forename: Mao
authors.initials: M
authors.lastname: Watanabe
authors.forename: Tamami
authors.initials: T
authors.lastname: Morisaki
authors.forename: Naoki
authors.initials: N
authors.lastname: Aomatsu
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakamura
authors.forename: Hidemi
authors.initials: H
authors.lastname: Kawajiri
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takashima
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Onoda
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Kenichi
authors.initials: K
authors.lastname: Wakasa
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary / Q000628:therapy; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000556:secondary / Q000628:therapy*; D008875:Middle Aged; D009367:Neoplasm Staging; D016896:Treatment Outcome