title: Detection of carboxyhemefibrinogen and methemefibrinogen in a patient with thrombosis of a HeartMate II ventricular assist device.
abstract: Ventricular assist device (VAD) thrombosis is a devastating, potentially fatal complication suffered by patients requiring mechanical circulatory support. We present a patient with thrombosis of a HeartMate II VAD with concurrent hemolysis and increased carbon monoxide formation. Using a specialized thrombelastographic assay, we detected marked plasmatic hypercoagulability mediated in part by the formation of carboxyhemefibrinogen.
authors.affiliation: Department of Surgery, The University of Arizona College of Medicine, Tucson, Arizona 85724-5114, USA.
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Smith
authors.forename: Vance G
authors.initials: VG
authors.lastname: Nielsen
mesh_terms: D000368:Aged; D002248:Carbon Monoxide / Q000097:blood; D002263:Carboxyhemoglobin / Q000378:metabolism; D009202:Cardiomyopathies / Q000601:surgery; D005340:Fibrinogen / Q000031:analogs & derivatives* / Q000378:metabolism; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006461:Hemolysis; D006801:Humans; D008297:Male; D008706:Methemoglobin / Q000378:metabolism; D013916:Thrombelastography; D019851:Thrombophilia / Q000097:blood / Q000209:etiology; D013927:Thrombosis / Q000097:blood* / Q000209:etiology*
chemical_list: D002248:Carbon Monoxide; D005340:Fibrinogen; D008706:Methemoglobin; D002263:Carboxyhemoglobin