title: In vitro bactericidal activity of Jinghua Weikang Capsule and its individual herb Chenopodium ambrosioides L. against antibiotic-resistant Helicobacter pylori.
abstract: OBJECTIVE
  To investigate the bactericidal effects of Jinghua Weikang Capsule and its major component Chenopodium ambrosioides L. on antibiotic-resistant Helicobacter pylori.
  
  
  METHODS
  Four clinical antibiotic-resistant H. pylori strains were isolated and incubated in liquid medium containing Jinghua Weikang Capsule or Chenopodium ambrosioides L. By means of time-kill curve method, the average colony counts and bactericidal rate were calculated at time points of 0, 4, 8 and 24 h after the incubation and the time-kill curves were charted.
  
  
  RESULTS
  Both Jinghua Weikang Capsule and Chenopodium ambrosioides L. at a concentration of 0.64 g/L showed obvious bactericidal effect against antibiotic-resistant H. pylori after 4 h of incubation.
  
  
  CONCLUSIONS
  Jinghua Weikang Capsule and Chenopodium ambrosioides L. are considered to be active against antibiotic-resistant H. pylori in vitro.
authors.affiliation: Department of Tradional Chinese Medicine and Integrated Tradional Chinese and Western Medicine, Peking University First Hospital, Beijing, 100034, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Xue-Zhi
authors.initials: XZ
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Cheng
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D027464:Chenopodium ambrosioides; D004352:Drug Resistance, Microbial; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016481:Helicobacter Infections / Q000188:drug therapy / Q000503:physiopathology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D028321:Plant Preparations / Q000494:pharmacology; D012680:Sensitivity and Specificity
chemical_list: D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D028321:Plant Preparations; C527855:jinghua weikang