title: The influence of high intensity terahertz radiation on mammalian cell adhesion, proliferation and differentiation.
abstract: Understanding the influence of exposure of biological systems to THz radiation is becoming increasingly important. There is some evidence to suggest that THz radiation can influence important activities within mammalian cells. This study evaluated the influence of the high peak power, low average power THz radiation produced by the ALICE (Daresbury Laboratory, UK) synchrotron source on human epithelial and embryonic stem cells. The cells were maintained under standard tissue culture conditions, during which the THz radiation was delivered directly into the incubator for various exposure times. The influence of the THz radiation on cell morphology, attachment, proliferation and differentiation was evaluated. The study demonstrated that there was no difference in any of these parameters between irradiated and control cell cultures. It is suggested that under these conditions the cells are capable of compensating for any effects caused by exposure to THz radiation with the peak powers levels employed in these studies.
authors.affiliation: Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 3GA, UK. rlw@liverpool.ac.uk
authors.forename: Rachel
authors.initials: R
authors.lastname: Williams
authors.forename: Amy
authors.initials: A
authors.lastname: Schofield
authors.forename: Gareth
authors.initials: G
authors.lastname: Holder
authors.forename: Joan
authors.initials: J
authors.lastname: Downes
authors.forename: David
authors.initials: D
authors.lastname: Edgar
authors.forename: Paul
authors.initials: P
authors.lastname: Harrison
authors.forename: Michele
authors.initials: M
authors.lastname: Siggel-King
authors.forename: Mark
authors.initials: M
authors.lastname: Surman
authors.forename: David
authors.initials: D
authors.lastname: Dunning
authors.forename: Stephen
authors.initials: S
authors.lastname: Hill
authors.forename: David
authors.initials: D
authors.lastname: Holder
authors.forename: Frank
authors.initials: F
authors.lastname: Jackson
authors.forename: James
authors.initials: J
authors.lastname: Jones
authors.forename: Julian
authors.initials: J
authors.lastname: McKenzie
authors.forename: Yuri
authors.initials: Y
authors.lastname: Saveliev
authors.forename: Neil
authors.initials: N
authors.lastname: Thomsen
authors.forename: Peter
authors.initials: P
authors.lastname: Williams
authors.forename: Peter
authors.initials: P
authors.lastname: Weightman
mesh_terms: D002448:Cell Adhesion / Q000528:radiation effects; D002454:Cell Differentiation / Q000528:radiation effects*; D002460:Cell Line; D049109:Cell Proliferation / Q000528:radiation effects; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000528:radiation effects*; D004847:Epithelial Cells / Q000166:cytology* / Q000528:radiation effects*; D006801:Humans; D055053:Terahertz Radiation / Q000009:adverse effects*