title: Asymmetric vinylogous aldol reaction via H-bond-directing dienamine catalysis.
abstract: The enantioselective direct vinylogous aldol reaction of 3-methyl 2-cyclohexen-1-one with α-keto esters has been developed. The key to success was the design of a bifunctional primary amine-thiourea catalyst that can combine H-bond-directing activation and dienamine catalysis. The simultaneous dual activation of the two reacting partners results in high reactivity while securing high levels of stereocontrol.
authors.affiliation: ICIQ - Institute of Chemical Research of Catalonia, Av. Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Bastida
authors.forename: Yankai
authors.initials: Y
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: Tian
authors.forename: Eduardo
authors.initials: E
authors.lastname: Escudero-Adán
authors.forename: Paolo
authors.initials: P
authors.lastname: Melchiorre