title: Practical considerations in the development and refinement of subcallosal cingulate white matter deep brain stimulation for treatment-resistant depression.
abstract: BACKGROUND
  Deep brain stimulation has been investigated in the past decade as a viable intervention for treatment-resistant depression.
  
  
  METHODS
  Several anatomic targets have been tested, with the most extensive published experience found for the subcallosal cingulate (SCC) white matter.
  
  
  RESULTS
  This article reviews the current state of clinical research of SCC deep brain stimulation for treatment-resistant depression, including an overview of the rationale for targeting SCC, practical considerations for subject recruitment and evaluation, surgical planning, and stimulation parameters.
  
  
  CONCLUSIONS
  Clinical management of patients in the initial and long-term naturalistic phases of treatment, including the potential role for psychotherapeutic rehabilitation, is discussed.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: privapo@emory.edu.
authors.forename: Patricio
authors.initials: P
authors.lastname: Riva-Posse
authors.forename: Paul E
authors.initials: PE
authors.lastname: Holtzheimer
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Garlow
authors.forename: Helen S
authors.initials: HS
authors.lastname: Mayberg
mesh_terms: D003337:Corpus Callosum / Q000601:surgery*; D046690:Deep Brain Stimulation / Q000379:methods*; D061218:Depressive Disorder, Treatment-Resistant / Q000523:psychology* / Q000534:rehabilitation / Q000601:surgery*; D005500:Follow-Up Studies; D006179:Gyrus Cinguli / Q000601:surgery*; D006801:Humans; D008134:Long-Term Care; D011613:Psychotherapy