title: Antigen shedding into the circulation contributes to tumor immune escape.
abstract: Tumors employ various mechanisms to escape elimination by the immune system. In addition to the local induction of immunosuppressive cell types such as regulatory T cells or myeloid derived suppressor cells, tumor antigen shedding into the circulation may suppress antitumor CD8(+) T-cell function via tolerogenic liver sinusoidal endothelial cells.
authors.affiliation: Institutes of Molecular Medicine and Experimental Immunology; University of Bonn; Bonn, Germany.
authors.forename: Bastian
authors.initials: B
authors.lastname: Höchst
authors.forename: Linda
authors.initials: L
authors.lastname: Diehl