title: [Usefulness of subarachnoid phenol-glycerin block therapy for enabling cancer patients with refractory anal pain to proceed to home-based care].
abstract: In recent years, the number of cancer patients and their families desiring palliative home-based care in Japan has increased. Subarachnoid phenol-glycerin block therapy is offered to relieve refractory anal pain in cancer patients, and to reduce the side effects of systemic administration of opioids, such as drowsiness. The effects of phenol-glycerin, which is a medicine used for neurodegenerative diseases, lasted for 1 week to 3 months. Eight patients with this manipulation showed a significant improvement in their pain level, calculated by the numerical rating scale(NRS). Five of these patients could proceed to homebased care. It is important to establish common guidelines for the management of phenol-glycerin. The participation of pharmacists in the palliative care team will contribute to further growth of home-based care.
authors.affiliation: Dept. of Pharmacy, The Jikei University School of Medicine.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Hayashi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Inoue
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Sakuyama
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Tanifuji
authors.forename: Kunio
authors.initials: K
authors.lastname: Moriya
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawakubo
mesh_terms: D000368:Aged; D001004:Anus Diseases / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005990:Glycerol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006699:Home Care Services; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000628:therapy; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology; D013346:Subarachnoid Space / Q000187:drug effects
chemical_list: C018631:phenolglycerin; D005990:Glycerol