title: Efficacy and safety of doripenem for sepsis with neutropenia in Japanese patients with hematologic diseases.
abstract: Doripenem (DRPM) is one of the carbapenems which has a broad-spectrum and strong activity against Pseudomonas aeruginosa. This observational study was conducted between April 2006 and March 2007 in Japan to evaluate the efficacy and safety of DRPM 0.5 g three times a day for sepsis with neutropenia in patients with hematologic diseases. One hundred-nineteen patients were enrolled from 34 medical institutes, comprising 117 patients for safety evaluation and 104 for efficacy evaluation. Monotherapy of DRPM 0.5 g three times a day (DRPM monotherapy) was evaluated in 73 patients. The response rates of DRPM monotherapy at 72 hours and at Day 7 were 31.5% (23/73) and 67.1% (49/73), respectively. The incidence of adverse reactions including abnormal changes in laboratory values was 23.1%, and hepatic toxicity was most common. All of these adverse events were judged by the investigators as non-serious and tolerable. These results suggest that DRPM is useful for sepsis with neutropenia, though further study may be warranted.
authors.affiliation: Department of Internal Medicine, Teikyo University School of Medicine.
authors.forename: Nobu
authors.initials: N
authors.lastname: Akiyama
authors.forename: Akihisa
authors.initials: A
authors.lastname: Kanamaru
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tamura
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Akio
authors.initials: A
authors.lastname: Urabe
authors.forename: Toru
authors.initials: T
authors.lastname: Masaoka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015780:Carbapenems / Q000009:adverse effects / Q000627:therapeutic use*; D000077726:Doripenem; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy*; D011446:Prospective Studies; D018805:Sepsis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D000077726:Doripenem