title: Protective function of an unconventional γδ T cell subset against malaria infection in apoptosis inhibitor deficient mice.
abstract: Various subsets of T-cell receptor (TCR) γδ⁺ T cells expressing distinct TCR-Vγ chains are found in many different anatomical locations. These TCR γδ⁺ T cells perform multiple functions as an essential part of the immune system. In particular, protection against malaria infection by TCR γδ⁺ T cells is of special interest. In the present study, we confirmed that the Vγ7⁺ γδ T cells, which are an unconventional subset usually localized within the intestine, are recruited to the liver and spleen at the late stage of malaria infection, and contribute to protection against malaria infection via a multifunctional approach in apoptosis inhibitor-deficient mice.
authors.affiliation: Transdisciplinary Research Organization for Subtropics and Island Studies, University of the Ryukyus, Okinawa, Japan. changchu@comb.u-ryukyu.ac.jp
authors.forename: Changchun
authors.initials: C
authors.lastname: Li
authors.forename: Kaiissar
authors.initials: K
authors.lastname: Mannoor
authors.forename: Masashi
authors.initials: M
authors.lastname: Inafuku
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Yuba
authors.initials: Y
authors.lastname: Inamine
authors.forename: Toru
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Hisami
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D017209:Apoptosis; D002465:Cell Movement; D004912:Erythrocytes / Q000469:parasitology; D051034:Inhibitor of Apoptosis Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D008288:Malaria / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018512:Parasitemia; D010967:Plasmodium yoelii / Q000276:immunology* / Q000472:pathogenicity; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta