title: Genetic variability in platelet integrin α2β1 density: possible contributor to Plasmodium vivax-induced severe thrombocytopenia.
abstract: Understanding the pathogenesis of Plasmodium vivax malaria is challenging. We hypothesized that susceptibility to P. vivax-induced thrombocytopenia could be associated with polymorphisms on relevant platelet membrane integrins: integrin α2 (C807T), and integrin β3 (T1565C). Although β3 polymorphism was not related with P. vivax malaria, α2 807T carriers, which show high levels of integrin α2β1, had a higher probability for severe thrombocytopenia than wild-type carriers. This evidence of the association of integrin polymorphism and P. vivax morbidity was further demonstrated by a moderate but significant correlation between clinical disease and surface levels of the integrin α2β1.
authors.affiliation: Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil. fernanda@cpqrr.fiocruz.br
authors.forename: Fernanda M F
authors.initials: FM
authors.lastname: Campos
authors.forename: Marina L S
authors.initials: ML
authors.lastname: Santos
authors.forename: Flora S
authors.initials: FS
authors.lastname: Kano
authors.forename: Cor J F
authors.initials: CJ
authors.lastname: Fontes
authors.forename: Marcus V G
authors.initials: MV
authors.lastname: Lacerda
authors.forename: Cristiana F A
authors.initials: CF
authors.lastname: Brito
authors.forename: Luzia H
authors.initials: LH
authors.lastname: Carvalho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006801:Humans; D039421:Integrin alpha2 / Q000235:genetics / Q000378:metabolism; D038982:Integrin alpha2beta1 / Q000235:genetics* / Q000378:metabolism; D039661:Integrin beta3 / Q000235:genetics / Q000378:metabolism; D016780:Malaria, Vivax / Q000235:genetics* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010966:Plasmodium vivax / Q000472:pathogenicity*; D011110:Polymorphism, Genetic; D013921:Thrombocytopenia / Q000469:parasitology*; D055815:Young Adult
chemical_list: D039421:Integrin alpha2; D038982:Integrin alpha2beta1; D039661:Integrin beta3