title: Familial leiomyomatosis cutis affecting nine family members in two successive generations including four cases of Reed's syndrome.
abstract: Reed's syndrome or familial leiomyomatosis cutis et uteri is an autosomal dominant disorder, characterized by multiple cutaneous and uterine leiomyomas. We report here a case of a 53-year-old woman who presented to us with multiple painful nodules over different parts of her body. Based on the histopathological examination, imaging, and past medical records, a diagnosis of Reed's syndrome was made. Three of her sisters had similar disease. Subsequently, it was found that a total of nine members of their family in two successive generations were affected with cutaneous leiomyomas. The present case series has been reported for its interesting clinical presentations and rarity.
authors.affiliation: Department of Dermatology, Venereology, and Leprosy, North Bengal Medical College, Darjeeling, West Bengal, India.
authors.forename: Rajesh Kumar
authors.initials: RK
authors.lastname: Mandal
authors.forename: Sankha
authors.initials: S
authors.lastname: Koley
authors.forename: Sabyasachi
authors.initials: S
authors.lastname: Banerjee
authors.forename: Sankar Prasad
authors.initials: SP
authors.lastname: Kabiraj
authors.forename: Sudip Kumar
authors.initials: SK
authors.lastname: Ghosh
authors.forename: Piyush
authors.initials: P
authors.lastname: Kumar
mesh_terms: D005260:Female; D005649:Fumarate Hydratase / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D018231:Leiomyomatosis / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary; D010375:Pedigree; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology*
chemical_list: D005649:Fumarate Hydratase