title: Protein translocation across the rough endoplasmic reticulum.
abstract: The rough endoplasmic reticulum is a major site of protein biosynthesis in all eukaryotic cells, serving as the entry point for the secretory pathway and as the initial integration site for the majority of cellular integral membrane proteins. The core components of the protein translocation machinery have been identified, and high-resolution structures of the targeting components and the transport channel have been obtained. Research in this area is now focused on obtaining a better understanding of the molecular mechanism of protein translocation and membrane protein integration.
authors.affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.
authors.forename: Elisabet C
authors.initials: EC
authors.lastname: Mandon
authors.forename: Steven F
authors.initials: SF
authors.lastname: Trueman
authors.forename: Reid
authors.initials: R
authors.lastname: Gilmore
mesh_terms: D018870:Endoplasmic Reticulum, Rough / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000502:physiology; D008957:Models, Genetic; D008958:Models, Molecular; D014176:Protein Biosynthesis; D021382:Protein Sorting Signals; D017434:Protein Structure, Tertiary; D021381:Protein Transport / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D021382:Protein Sorting Signals; D012333:RNA, Messenger