title: Correlation of Fc-γ RIIA polymorphisms with latent Epstein-Barr virus infection and latent membrane protein 1 expression in patients with low grade B-cell lymphomas.
abstract: Fc-γ RIIA (CD32), a member of the family of Fc-γ receptors, participates in the phagocytosis of bound to antibody antigens. The effectiveness of this function varies for its several haplotypes, and it participates in the pathogenesis of viral infections, according to recent studies. The genetic locus of Fc-γ RIIA consists of two allelic genes: 131-Arg (R131) and 131-His (H131). Our aim was to correlate Fc-γ RIIA polymorphisms, by studying the prevalence of each allele using PCR-RFLPs (polymerase chain reaction-restriction fragment length polymorphisms), with latent Epstein-Barr virus (EBV) infection and the expression of latent membrane protein 1 (LMP1) in 40 patients with leukemic low grade B-cell lymphomas. R131 was found in 84.2% of EBV-positive patients, but only in 28.5% of EBV-negative patients (p = 0.001). A similar correlation was found for R131 and LMP1 expression (84.6% vs. 28.5%) (p = 0.002). Our results support the hypothesis that Fc-γ RIIA polymorphisms are a genetic risk factor for latent EBV infection and the expression of its oncogenic latency proteins.
authors.affiliation: 1st Department of Internal Medicine, Hematology Unit, Laikon General Hospital, National and Kapodistrian University of Athens, Greece. pandiamantopoulos@gmail.com
authors.forename: Panagiotis T
authors.initials: PT
authors.lastname: Diamantopoulos
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Kalotychou
authors.forename: Katerina
authors.initials: K
authors.lastname: Polonyfi
authors.forename: Maria
authors.initials: M
authors.lastname: Sofotasiou
authors.forename: Amalia
authors.initials: A
authors.lastname: Anastasopoulou
authors.forename: Athanassios
authors.initials: A
authors.lastname: Galanopoulos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Spanakis
authors.forename: Theodoros
authors.initials: T
authors.lastname: Vassilakopoulos
authors.forename: Maria
authors.initials: M
authors.lastname: Angelopoulou
authors.forename: Maria
authors.initials: M
authors.lastname: Siakantaris
authors.forename: Eleni
authors.initials: E
authors.lastname: Variami
authors.forename: Christos
authors.initials: C
authors.lastname: Poziopoulos
authors.forename: Evangelos
authors.initials: E
authors.lastname: Terpos
authors.forename: Panagoula
authors.initials: P
authors.lastname: Kollia
authors.forename: Nora-Athina
authors.initials: NA
authors.lastname: Viniou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D014763:Viral Matrix Proteins / Q000235:genetics*
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; C080568:Fc gamma receptor IIA; D017452:Receptors, IgG; D014763:Viral Matrix Proteins