title: Trends in the frequency of HLA DR-DQ haplotypes among children and adolescents with type 1 diabetes mellitus in the Southeast Region of Turkey.
abstract: OBJECTIVE
  The aim of this study was to determine the frequency of HLA DR-DQ haplotypes in children with type 1 diabetes mellitus (T1DM) in the Southeast Region of Turkey.
  
  
  METHODS
  Eighty children and adolescents with T1DM and eighty control subjects participated in the study. HLA-DR, DQ was typed using polymerase chain reaction and sequence-specific priming technique.
  
  
  RESULTS
  HLA DRB1*03 allele was significantly more common in patients than in control subjects. HLA DRB1*11, HLA DRB1*13 and HLA DRB1*14 allele frequencies were significantly lower in patients than in controls. DQB1*02 allele was more common in patients, whereas DQB1*03 allele was more frequent in control subjects. HLA DRB1*03-DQB1*02 haplotype was more frequently observed among patients.
  
  
  CONCLUSIONS
  These results confirm the similar potential trends in the frequency distribution of HLA susceptibility genes with T1DM previously observed in Turkey and in other Caucasian populations.
authors.affiliation: Gaziantep University, Department of Pediatric Endocrinology and Metabolisms, Gaziantep, Turkey. mkeskin@gantep.edu.tr
authors.forename: Mehmet
authors.initials: M
authors.lastname: Keskin
authors.forename: Ayşe
authors.initials: A
authors.lastname: Aygün
authors.forename: Sacide
authors.initials: S
authors.lastname: Pehlivan
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Keskin
authors.forename: Yılmaz
authors.initials: Y
authors.lastname: Kor
authors.forename: Ayşe
authors.initials: A
authors.lastname: Balat
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Coşkun
mesh_terms: D000293:Adolescent; D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D059866:HLA-DQ beta-Chains / Q000097:blood / Q000235:genetics / Q000378:metabolism; D006684:HLA-DR Antigens / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D059811:HLA-DRB1 Chains / Q000097:blood / Q000235:genetics / Q000378:metabolism; D006239:Haplotypes; D006785:Hospitals, University; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D014421:Turkey
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains