title: Exertional acidotic responses in idiopathic pulmonary fibrosis: the mechanisms of exertional dyspnea.
abstract: To understand the mechanism of exertional dyspnea, we postulated that, despite hyperoxia during exercise, patients with idiopathic pulmonary fibrosis (IPF) might not regulate exertional acidosis by ventilatory compensation to stop exercise. The exercise responses during 30% O(2) or compressed air (CA) were examined in 13 patients with IPF. The PaO(2), PaCO(2), and HCO(3)(-) levels were higher during exercise with hyperoxia than with CA. At peak exercise, hyperoxia reduced the plasma lactate level. The dyspnea-ratio (%) of the ΔV(O(2)) (peak minus resting oxygen uptake) curve reached a break point that occurred at a similar exercise point with hyperoxia and CA, preceded by a break point in the breathing frequency-ratio of the ΔV(O(2)). Accordingly, the dyspnea score and pH each reached similar levels with hyperoxia and CA to stop exercise. Regardless of breathing CA or 30% O(2), IPF patients did not regulate exertional acidosis by ventilatory compensation to stop exercise, resulting in reaching a specific pH.
authors.affiliation: Department of Internal Medicine, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan. mikisuke@toneyama.go.jp
authors.forename: Keisuke
authors.initials: K
authors.lastname: Miki
authors.forename: Ryoji
authors.initials: R
authors.lastname: Maekura
authors.forename: Mari
authors.initials: M
authors.lastname: Miki
authors.forename: Seigo
authors.initials: S
authors.lastname: Kitada
authors.forename: Kenji
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Tateishi
authors.forename: Masahide
authors.initials: M
authors.lastname: Mori
mesh_terms: D000138:Acidosis / Q000503:physiopathology*; D000368:Aged; D004417:Dyspnea / Q000209:etiology / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000150:complications / Q000503:physiopathology*; D008297:Male; D012129:Respiratory Function Tests