title: Monosomal karyotype in acute myeloid leukemia defines a distinct subgroup within the adverse cytogenetic risk category.
abstract: Monosomal karyotype (MK) has recently been reported to identify a distinct subset of acute myeloid leukemia (AML) with adverse prognosis. We retrospectively evaluated the frequency of MK in a large cohort of 549 unselected AML cases diagnosed in our department over a period of 13 years and explored potential associations with clinicobiological features and outcome. MK was found in 62 of 549 cases (11.3%), with all but one assigned to the unfavorable cytogenetic risk category; 57 of these 62 MK cases had a complex karyotype. Comparison with a subgroup of AML cases, who had unfavorable karyotypic profiles yet without MK (non-MK) and who were treated uniformly with similar, "3+7"-based regimens, revealed significant (P < 0.05) associations between MK and advanced age, low white blood cell count at diagnosis, and inferior overall survival (6.5 vs. 15 months for non-MK cases). In conclusion, MK defines a sizeable subset of patients with unfavorable cytogenetics who exhibit a distinct clinical profile, even in direct comparison with other unfavorable karyotypes.
authors.affiliation: Hematology Department and Hematopoietic Cell Transplantation (HCT) Unit, G. Papanicolaou Hospital, Thessaloniki, Greece.
authors.forename: Georgia
authors.initials: G
authors.lastname: Voutiadou
authors.forename: George
authors.initials: G
authors.lastname: Papaioannou
authors.forename: Maria
authors.initials: M
authors.lastname: Gaitatzi
authors.forename: Chrysavgi
authors.initials: C
authors.lastname: Lalayanni
authors.forename: Antonia
authors.initials: A
authors.lastname: Syrigou
authors.forename: Chrysanthi
authors.initials: C
authors.lastname: Vadikoliou
authors.forename: Riad
authors.initials: R
authors.lastname: Saloum
authors.forename: Achilles
authors.initials: A
authors.lastname: Anagnostopoulos
authors.forename: Anastasia
authors.initials: A
authors.lastname: Athanasiadou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003582:Cytogenetics; D005260:Female; D006801:Humans; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000145:classification* / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009006:Monosomy / Q000175:diagnosis; D011379:Prognosis; D012189:Retrospective Studies; D012306:Risk; D016019:Survival Analysis; D055815:Young Adult