title: Silicone hydrogel lens-solution interaction and inflammation.
abstract: Daily wear of silicone hydrogel (SiHy) lenses using marketed lens care solutions results in varied levels of anterior eye inflammation. There are several pathways that may lead to corneal and conjunctival inflammation that include mechanical, allergic, and pathogen driven stimuli. The hypotheses and evidence for these various models of inflammation will be discussed in the context of SiHy lens designs and materials and lens care solution components.
authors.affiliation: Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom. nicolecarnt@gmail.com
authors.forename: Nicole
authors.initials: N
authors.lastname: Carnt
authors.forename: Fiona
authors.initials: F
authors.lastname: Stapleton
mesh_terms: D018639:Contact Lens Solutions / Q000009:adverse effects* / Q000032:analysis*; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D019793:Fluorescein; D006801:Humans; D020100:Hydrogels / Q000009:adverse effects*; D007634:Keratitis / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D012828:Silicones
chemical_list: D018639:Contact Lens Solutions; D020100:Hydrogels; D012828:Silicones; D019793:Fluorescein