title: Respiratory muscle function in interstitial lung disease.
abstract: Interstitial lung diseases limit daily activities, impair quality of life and result in (exertional) dyspnoea. This has mainly been attributed to a decline in lung function and impaired gas exchange. However, the contribution of respiratory muscle dysfunction to these limitations remains to be conclusively investigated. Interstitial lung disease patients and matched controls performed body plethysmography, a standardised 6-min walk test, volitional tests (respiratory drive (P0.1), global maximal inspiratory mouth occlusion pressure (PImax), sniff nasal pressure (SnPna) and inspiratory muscle load) and nonvolitional tests on respiratory muscle function and strength (twitch mouth and transdiaphragmatic pressure during bilateral magnetic phrenic nerve stimulation (TwPmo and TwPdi)). 25 patients and 24 controls were included in the study. PImax and SnPna remained unaltered (both p>0.05), whereas P0.1 and the load on the inspiratory muscles were higher (both p<0.05) in interstitial lung disease patients compared with controls. TwPmo and TwPdi were lower in interstitial lung disease patients (mean±sd TwPmo 0.86±0.4 versus 1.32±0.4, p<0.001; TwPdi 1.34±0.6 versus 1.88±0.5, p=0.022). Diaphragmatic force generation seems to be impaired in this cohort of interstitial lung disease patients while global respiratory muscle strength remains preserved. Central respiratory drive and the load imposed on the inspiratory muscles are increased. Whether impaired respiratory muscle function impacts morbidity and mortality in interstitial lung disease patients needs to be investigated in future studies.
authors.affiliation: Dept of Pneumology, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Walterspacher
authors.forename: Daniel
authors.initials: D
authors.lastname: Schlager
authors.forename: David J
authors.initials: DJ
authors.lastname: Walker
authors.forename: Joachim
authors.initials: J
authors.lastname: Müller-Quernheim
authors.forename: Wolfram
authors.initials: W
authors.lastname: Windisch
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Kabitz
mesh_terms: D000368:Aged; D000886:Anthropometry; D015415:Biomarkers / Q000378:metabolism; D002248:Carbon Monoxide / Q000737:chemistry; D016022:Case-Control Studies; D003964:Diaphragm / Q000503:physiopathology; D005080:Exercise Test; D005260:Female; D006801:Humans; D001239:Inhalation; D017563:Lung Diseases, Interstitial / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010991:Plethysmography; D012129:Respiratory Function Tests; D012132:Respiratory Muscles / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D002248:Carbon Monoxide