title: Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.
abstract: Magnetisation transfer ratio (MTR) can reveal the degree of proton exchange between free water and macromolecules and was suggested to be pathological informative. We aimed to investigate changes in optic nerve MTR over 12 months following acute optic neuritis (ON) and to determine whether MTR measurements can predict clinical and paraclinical outcomes at 6 and 12 months. Thirty-seven patients with acute ON were studied within 2 weeks of presentation and at 1, 3, 6 and 12 months. Assessments included optic nerve MTR, retinal nerve fibre layer (RNFL) thickness, multifocal visual evoked potential (mfVEP) amplitude and latency and high (100%) and low (2.5%) contrast letter acuity. Eleven healthy controls were scanned twice four weeks apart for comparison with patients. Patient unaffected optic nerve MTR did not significantly differ from controls at any time-point. Compared to the unaffected nerve, affected optic nerve MTR was significantly reduced at 3 months (mean percentage interocular difference = -9.24%, p = 0.01), 6 months (mean = -12.48%, p<0.0001) and 12 months (mean = -7.61%, p = 0.003). Greater reduction in MTR at 3 months in patients was associated with subsequent loss of high contrast letter acuity at 6 (ρ = 0.60, p = 0.0003) and 12 (ρ = 0.44, p = 0.009) months, low contrast letter acuity at 6 (ρ = 0.35, p = 0.047) months, and RNFL thinning at 12 (ρ = 0.35, p = 0.044) months. Stratification of individual patient MTR time courses based on flux over 12 months (stable, putative remyelination and putative degeneration) predicted RNFL thinning at 12 months (F(2,32) = 3.59, p = 0.02). In conclusion, these findings indicate that MTR flux after acute ON is predictive of axonal degeneration and visual disability outcomes.
authors.affiliation: The Centre for Neuroscience Research, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Yejun
authors.initials: Y
authors.lastname: Wang
authors.forename: Anneke
authors.initials: A
authors.lastname: van der Walt
authors.forename: Mark
authors.initials: M
authors.lastname: Paine
authors.forename: Alexander
authors.initials: A
authors.lastname: Klistorner
authors.forename: Helmut
authors.initials: H
authors.lastname: Butzkueven
authors.forename: Gary F
authors.initials: GF
authors.lastname: Egan
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Kilpatrick
authors.forename: Scott C
authors.initials: SC
authors.lastname: Kolbe
mesh_terms: D000208:Acute Disease; D000328:Adult; D001369:Axons / Q000473:pathology; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009900:Optic Nerve / Q000503:physiopathology; D009902:Optic Neuritis / Q000175:diagnosis* / Q000503:physiopathology*; D011379:Prognosis; D015203:Reproducibility of Results; D014785:Vision, Ocular