title: [Protection effect of Corn Shuang on hyperlipidemic rats vascular wall].
abstract: OBJECTIVE
  To study the protection of Corn Shuang on hyperlipidemic rats vascular wall and its mechanism of action.
  
  
  METHODS
  Thirty Wistar rats were randomly divided into control group, model group and test group (n = 10). Feeding rats according to the experiment requirement, after 15 weeks,the content of lipids, superoxide dismutase (SOD), serum glutathione peroxidase (GSH-Px), malondialdehyde (MDA), nitric oxide (NO) and nitric oxide synthase (NOS) were measured in each group rats serum, morphological changes of rat aortic wall tissue were observed by light microscopy.
  
  
  RESULTS
  The concentration of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and MDA increased significantly in model group (P < 0.01), the concentration of high density lipoprotein (HDL-C), SOD, GSH-Px, NO and NOS decreased significantly (P < 0.01); Corn Shuang could reduce the concentration of TC, TG, LDL-C and MDA in hyperlipidemia rats serum (P < 0.01), promote the content of HDL-C, SOD, GSH-Px, NO and NOS (P < 0.01); Aortic wall showed typical atherosclerotic lesion in model group; Corn shuang could improve significantly damages of artery wall.
  
  
  CONCLUSIONS
  Corn Shuang had obvious protective effect on the vessel wall, its mechanism might be related to regulation of blood lipid, antioxidant, maintenance of NO metabolism.
authors.affiliation: Medical School of Hubei Instiute for Nationalities, Enshi 445000, China. tanwenbotanqian@163.com
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Tan
authors.forename: Fu-Ming
authors.initials: FM
authors.lastname: Yang
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood*; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D019001:Nitric Oxide Synthase / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D014280:Triglycerides / Q000097:blood; D003313:Zea mays
chemical_list: D008055:Lipids; D008077:Lipoproteins, LDL; D014280:Triglycerides; D008315:Malondialdehyde; D002784:Cholesterol; D005979:Glutathione Peroxidase; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase