title: Intrathecal hydromorphone for cesarean delivery: in search of improved postoperative pain management: a case report.
abstract: Currently, morphine and fentanyl are the most commonly used intrathecal opioids for the postoperative pain management of patients who underwent cesarean delivery. Unfortunately, the analgesic benefits of these 2 drugs tend to fall into different extremes based on lipid solubility. Intrathecal hydromorphone may provide more consistent analgesia because its lipid solubility falls between that of the other 2 opioids. A 22-year-old woman with a 39-week intrauterine pregnancy, gravida 2, para 1, came in for a scheduled second-time cesarean delivery. Her preoperative history included a morphine allergy discovered when administered intrathecally during her first cesarean delivery. Thus, in this case, preservative-free hydromorphone, 100 microg, was administered intrathecally as the opioid replacement for the spinal anesthetic. Intrathecal hydromorphone was found to have provided superior pain relief with fewer side effects in this patient, who received intrathecal morphine for the same surgery 2 years earlier. This case report supports an emerging hypothesis that intrathecal hydromorphone is not only safe but possibly more effective than other intrathecal opioids for pain management after cesarean delivery. The purpose of this case report is to encourage the development of more research regarding this use of intrathecal hydromorphone.
authors.affiliation: Bayfront Medical Center, St Petersburg, Florida, USA. erauch@health.usf.edu
authors.forename: Erik
authors.initials: E
authors.lastname: Rauch
mesh_terms: D016362:Analgesia, Obstetrical / Q000379:methods*; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D002585:Cesarean Section; D005260:Female; D006801:Humans; D004091:Hydromorphone / Q000008:administration & dosage*; D007278:Injections, Spinal; D009719:Nurse Anesthetists; D010149:Postoperative Pain / Q000188:drug therapy*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D004091:Hydromorphone