title: [Anti-motion sickness efficacy of the extracted mixture of Chinese medical herbs and its influence on the blood level of hormones].
abstract: OBJECTIVE
  To investigate the anti-motion sickness efficacy and influence on the blood level of some hormones of a Chinese prescription composed of 10 herbs such as spina date seed.
  
  
  METHODS
  According to the report by Cramptom and Lucot, SD rats and Beagle dogs were rotated around a horizontal axis, and the rat behavior of pica for Kaolin and the latency to vomit in dog were observed. In addition, guinea pigs were rotated around a vertical axis, and the nystagmus was recorded. Blood levels of corticosterone, adrenocorticotrophic hormone (ACTH), corticotropin releasing hormone (CRH) and arginine vasopressin (AVP) in rats were measured with radioimmunoassay. The influences of the extracted mixture of herbs on these variables were simultaneously investigated.
  
  
  RESULTS
  Compared with control group, oral administration of the extracted mixture of herbs: (1) significantly inhibited the rat behavior of pica for Kaolin and prolonged the latency to vomit in dog dose-dependently; (2) decreased the frequency of nystagmus and mean slow phase speed in rat; (3) reduced the elevation of corticosterone, ACTH, CRH and AVP in rat blood induced by rotatory stimulation; and (4) these effects of the extracted mixture of herbs were almost identical to dimenhydrinate.
  
  
  CONCLUSIONS
  (1) The extracted mixture of Chinese Medicinal Herbs we used could inhibit motion sickness effectively. (2) This drug could reduce the blood levels of hormones of hypothalamic-pituitary-adrenocortical axis and AVP elevated by provocative rotatory stimulation.
authors.affiliation: Institute of Nautical Medicine, Nantong University, Nantong 226001, China.
authors.forename: Hua-Xiang
authors.initials: HX
authors.lastname: Shen
authors.forename: Zheng-Lin
authors.initials: ZL
authors.lastname: Jiang
authors.forename: Gen-Shan
authors.initials: GS
authors.lastname: Dong
authors.forename: Hong-Qi
authors.initials: HQ
authors.lastname: Yang
authors.forename: Rui
authors.initials: R
authors.lastname: Jiang
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Yin
authors.forename: Miao-Miao
authors.initials: MM
authors.lastname: Chen
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D003345:Corticosterone / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000097:blood; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009041:Motion Sickness / Q000097:blood* / Q000188:drug therapy*; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D001127:Arginine Vasopressin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone