title: Giant-cell-rich pseudotumour in Paget's disease.
abstract: Paget's disease (PD) of the bone is a disorder of bone remodelling that may be polyostotic or monostotic. Although development of a sarcoma in PD is well-recognised, it is less well recognised that pseudosarcomas in bone and soft tissue can also arise in this condition. In this report we document the case of a large giant-cell-rich pseudotumour that developed in the tibia and overlying soft tissues in a case of polyostotic PD. Bone and soft tissues were highly vascular and contained abundant haemorrhage with focal areas of new bone formation and a diffuse infiltrate of osteoclastic giant cells. The lesion has not recurred or produced metastases 3 years after removal. Clinicians should be aware that a benign giant-cell-rich pseudotumour can develop in PD and that it needs to be distinguished from other giant-cell-rich tumours.
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford, OX3 7LD, UK.
authors.forename: N M
authors.initials: NM
authors.lastname: Gamage
authors.forename: T G
authors.initials: TG
authors.lastname: Kashima
authors.forename: M A
authors.initials: MA
authors.lastname: McNally
authors.forename: C L M H
authors.initials: CL
authors.lastname: Gibbons
authors.forename: R
authors.initials: R
authors.lastname: Smith
authors.forename: S J
authors.initials: SJ
authors.lastname: Ostlere
authors.forename: N A
authors.initials: NA
authors.lastname: Athanasou
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D005870:Giant Cell Tumors / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D015726:Giant Cells / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007866:Leg / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008297:Male; D010001:Osteitis Deformans / Q000150:complications*; D011859:Radiography; D012983:Soft Tissue Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome