title: Continuous-flow encapsulation of ketoprofen in copolymer microbeads via co-axial microfluidic device: influence of operating and material parameters on drug carrier properties.
abstract: Microchannels based microfluidic systems are able to obtain monodispersed microparticles but are limited by cost, time and channel clogging. We succeeded in on the fly encapsulation of high ketoprofen contents in acrylate-based copolymer microbeads by environment friendly UV induced free radical polymerization in off-the-shelf co-axial microfluidic device. FTIR shows complete polymerization of acrylate monomers and interaction between carboxylic group of ketoprofen and ester group of monomers. DSC and XRD confirm amorphous nature of drug in microbeads. Different comonomer content formulations show limited drug release at low pH, a helpful properties to avoid gastric irritating effect of ketoprofen associated with conventional dosage forms. At pH 6.8 microbeads release higher content of drug by a non-Fickian diffusion mechanism. Their drug release rate depends upon the weight content of ethyl acrylate in the formulation as well as their size, increasing by increasing the former and decreasing the later.
authors.affiliation: Université de Strasbourg, Faculté de Pharmacie, Laboratoire de Conception et Application de Molécules Bioactives - CNRS 7199, Equipe de Pharmacie Biogalénique, 74 route du Rhin, F-67400 Illkirch, France.
authors.forename: Ikram Ullah
authors.initials: IU
authors.lastname: Khan
authors.forename: Christophe A
authors.initials: CA
authors.lastname: Serra
authors.forename: Nicolas
authors.initials: N
authors.lastname: Anton
authors.forename: Thierry
authors.initials: T
authors.lastname: Vandamme
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005609:Free Radicals / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007660:Ketoprofen / Q000008:administration & dosage* / Q000737:chemistry; D044085:Microfluidics; D008863:Microspheres; D058105:Polymerization; D017550:Spectroscopy, Fourier Transform Infrared; D014466:Ultraviolet Rays; D014961:X-Ray Diffraction
chemical_list: D000179:Acrylates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005609:Free Radicals; D007660:Ketoprofen