title: Undercarboxylated osteocalcin does not correlate with insulin resistance as assessed by euglycemic hyperinsulinemic clamp technique in patients with type 2 diabetes mellitus.
abstract: BACKGROUND
  Recent in vitro and in vivo studies have suggested a critical role of osteocalcin (OC), especially the undercarboxylated form (ucOC), in insulin secretion and insulin sensitivity. The objective of this study was to investigate the association between serum ucOC levels and insulin resistance in humans with type 2 diabetes mellitus.
  
  
  RESULTS
  We measured serum ucOC levels in 129 patients with type 2 diabetes. Insulin resistance was assessed using the euglycemic hyperinsulinemic clamp technique. The insulin resistance indices used were the M value, which is the total body glucose disposal rate, and the M/I value, which is the M value adjusted for the steady state plasma insulin level. ucOC levels were not correlated with the M value (ρ = -0.013, p = 0.886) or the M/I value (ρ = 0.001, p = 0.995).
  
  
  CONCLUSIONS
  We found no association between ucOC levels and insulin resistance in patients with type 2 diabetes mellitus.
authors.affiliation: Deaprtment of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. ktmori@med.osaka-cu.ac.jp.
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Mori
authors.forename: Masanori
authors.initials: M
authors.lastname: Emoto
authors.forename: Koka
authors.initials: K
authors.lastname: Motoyama
authors.forename: Eiko
authors.initials: E
authors.lastname: Lee
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Yamada
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Morioka
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Imanishi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shoji
authors.forename: Masaaki
authors.initials: M
authors.lastname: Inaba