title: [Effect of sailuotong capsule on intervening cognitive dysfunction of multi-infarct dementia in rats].
abstract: OBJECTIVE
  To study the effect of Sailuotong capsule (Sailuotong) on learning and memory functions of multi-infarct dementia (MID) rats and its mechanism.
  
  
  METHODS
  All SD rats were divided into five groups, namely the sham operation group, the model group, the positive group, the low dosage Sailuotong-treated group and the high dosage Sailuotong-treated group. The multi-infarct dementia model was established by injecting the micro-sphere vascular occlusive agent. On the 10th day after the successful operation, the rats were administered intragastrically with distilled water, memantine hydrochloride (20 mg x kg(-1)) and Sailuotong (16.5 mg x kg(-1) and 33.0 mg x kg(-1)) once a day for 60 days respectively, in order to detect the effect of Sailuotong in different doses on the latent period and route length in Morris water maze and the activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AchE) in brain tissues.
  
  
  RESULTS
  Compared with the sham operation rats, it had been observed that the latent period and route length of MID rats in Morris water maze were significantly increased (P < 0.05 or P < 0.01), and the activity of ChAT in brain tissues was significantly decreased (P < 0.05). After the intervention with Sailuotong for sixty days, the latent period and route length of MID rats in Morris water maze significantly shrank (P < 0.05 or P < 0.01). Additionally, Sailuotong decreased AchE activity, while increasing ChAT activity in brain tissues of MID rats (P < 0.05 or P < 0.01).
  
  
  CONCLUSIONS
  Sailuotong capsule can improve cognitive dysfunction of MID rats to some extent. Its mechanism may be related to its different regulation of activities of ChAT and AchE in brain tissues.
authors.affiliation: Experimental Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Cheng-ren
authors.initials: CR
authors.lastname: Lin
authors.forename: Jian-xun
authors.initials: JX
authors.lastname: Liu
authors.forename: Jian-xun
authors.initials: JX
authors.lastname: Ren
authors.forename: Jun-mei
authors.initials: JM
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Hong-hai
authors.initials: HH
authors.lastname: Li
authors.forename: Wen-ting
authors.initials: WT
authors.lastname: Song
authors.forename: Ming-jiang
authors.initials: MJ
authors.lastname: Yao
authors.forename: Guang-rui
authors.initials: GR
authors.lastname: Wang
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D015161:Dementia, Multi-Infarct / Q000150:complications* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase