title: Calcified myocardial necrosis in pediatric patients after cardiopulmonary resuscitation.
abstract: We report three autopsy cases of wide-spread myocardial necrosis with calcification in pediatric patients after temporary generalized hypoxia and initially successful cardiopulmonary resuscitation, but subsequent in-hospital death. Autopsy and histological workup in all three cases showed multiple circumscribed calcified and necrotic areas in progressive stages of organization within the myocardium. We conclude that these macro- and microscopic autopsy features appear to be related to reperfusion injuries in children as a consequence of hypoxic-ischemic changes occurring in the peri- and postresuscitation period.
authors.affiliation: Institute of Legal Medicine and Forensic Sciences, Charité, Universitätsmedizin Berlin, Turmstr. 21, Building N, 10559, Berlin, Germany, claas.buschmann@charite.de.
authors.forename: Claas T
authors.initials: CT
authors.lastname: Buschmann
authors.forename: Werner
authors.initials: W
authors.lastname: Stenzel
authors.forename: Hubert
authors.initials: H
authors.lastname: Martin
authors.forename: Frank L
authors.initials: FL
authors.lastname: Heppner
authors.forename: Saskia S
authors.initials: SS
authors.lastname: Guddat
authors.forename: Michael
authors.initials: M
authors.lastname: Tsokos
mesh_terms: D000367:Age Factors; D001344:Autopsy; D002114:Calcinosis / Q000473:pathology*; D016887:Cardiopulmonary Resuscitation; D002423:Cause of Death; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006323:Heart Arrest / Q000473:pathology* / Q000628:therapy; D006801:Humans; D000860:Hypoxia / Q000473:pathology* / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis