title: Extracellular vesicles in physiological and pathological conditions.
abstract: Body fluids contain surprising numbers of cell-derived vesicles which are now thought to contribute to both physiology and pathology. Tools to improve the detection of vesicles are being developed and clinical applications using vesicles for diagnosis, prognosis, and therapy are under investigation. The increased understanding why cells release vesicles, how vesicles play a role in intercellular communication, and how vesicles may concurrently contribute to cellular homeostasis and host defense, reveals a very complex and sophisticated contribution of vesicles to health and disease.
authors.affiliation: Department of Clinical Chemistry, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Yuana
authors.initials: Y
authors.lastname: Yuana
authors.forename: Auguste
authors.initials: A
authors.lastname: Sturk
authors.forename: Rienk
authors.initials: R
authors.lastname: Nieuwland
mesh_terms: D001777:Blood Coagulation / Q000502:physiology; D001826:Body Fluids / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D003600:Cytosol / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D005089:Exocytosis / Q000502:physiology; D055354:Exosomes / Q000737:chemistry / Q000502:physiology*; D005110:Extracellular Space / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism; D057146:Multivesicular Bodies / Q000737:chemistry / Q000502:physiology*; D018919:Neovascularization, Physiologic