title: [A case of advanced rectal cancer treated effectively with intersphincteric resection and preoperative chemotherapy].
abstract: An approximately 50-year-old man with rectal cancer(RbP)[ cT3(cA), cN3, cM0, and cStage IIIb] who desired anus preservation was administered mFOLFOX6 therapy. This treatment decreased the size of both the tumor and the lymph node, and intersphincteric resection (ISR) was performed. Histopathology demonstrated tumor invasion beyond the muscularis propria, and the histological effectiveness was Grade 2. Because computed tomography showed an abscess in the dissection area, we performed postoperative drainage and the patient recovered. Therapy with mFOLFOX6 was repeated after the patient was discharged from hospital. Increased adoption of anus-preserving surgery is expected via successful control of local recurrence and distant metastasis by neoadjuvant chemotherapy.
authors.affiliation: Dept. of Surgery, Aomori Prefectural Central Hospital, Japan.
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Kimura
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Nishikawa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yachi
authors.forename: Yurie
authors.initials: Y
authors.lastname: Ito
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Kudo
authors.forename: Norihito
authors.initials: N
authors.lastname: Kubo
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Tokura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Umehara
authors.forename: Michihiro
authors.initials: M
authors.lastname: Kurushima
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Morita
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil