title: Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case-control study.
abstract: BACKGROUND
  The oxidative stress mechanism is of particular interest in the pathogenesis of glioma, given the high rate of oxygen metabolism in the brain. Potential links between polymorphisms of antioxidant genes and glioma risk are currently unknown. We therefore investigated the association between polymorphisms in antioxidant genes and glioma risk.
  
  
  METHODS
  We examined 16 single nucleotide polymorphisms (SNPs) of 9 antioxidant genes (GPX1, CAT, PON1, NQO1, SOD2/MnSOD, SOD3, and NOS1*2*3) in 384 glioma and 384 control cases in a Chinese hospital-based case-control study. Genotypes were determined using the OpenArray platform, which employs the chip-based Taq-Man genotyping technology. The adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using unconditional logistic regression.
  
  
  RESULTS
  Using single-locus analysis, we identified four SNPs (SOD2 V16A, SOD3 T58A, GPX1 -46 C/T, and NOS1 3'-UTR) that were significantly associated with the risk of glioma development. To assess the cumulative effects, we performed a combined unfavourable genotype analysis. Compared with the reference group that exhibited no unfavourable genotypes, the medium- and high-risk groups exhibited a 1.86-fold (95% CI, 1.30-2.67) and a 4.86-fold (95% CI, 1.33-17.71) increased risk of glioma, respectively (P-value for the trend < 0.001).
  
  
  CONCLUSIONS
  These data suggest that genetic variations in oxidative stress genes might contribute to the aetiology of glioma.
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. zhaopeng@njmu.edu.cn
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Zhao
authors.forename: Peng
authors.initials: P
authors.lastname: Zou
authors.forename: Ailin
authors.initials: A
authors.lastname: Lu
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Kang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Fu
authors.forename: Yongping
authors.initials: Y
authors.lastname: You
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000975:Antioxidants; D044466:Asian People / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D000975:Antioxidants