title: Selective diagnosis of diabetes using Pt-functionalized WO3 hemitube networks as a sensing layer of acetone in exhaled breath.
abstract: Thin-walled WO(3) hemitubes and catalytic Pt-functionalized WO(3) hemitubes were synthesized via a polymeric fiber-templating route and used as exhaled breath sensing layers for potential diagnosis of halitosis and diabetes through the detection of H(2)S and CH(3)COCH(3), respectively. Pt-functionalized WO(3) hemitubes with wall thickness of 60 nm exhibited superior acetone sensitivity (R(air)/R(gas) = 4.11 at 2 ppm) with negligible H(2)S response, and pristine WO(3) hemitubes showed a 4.90-fold sensitivity toward H(2)S with minimal acetone-sensing characteristics. The detection limit (R(air)/R(gas)) of the fabricated sensors with Pt-functionalized WO(3) hemitubes was 1.31 for acetone of 120 ppb, and pristine WO(3) hemitubes showed a gas response of 1.23 at 120 ppb of H(2)S. Long-term stability tests revealed that the remarkable selectivity has been maintained after aging for 7 months in air. The superior cross-sensitivity and response to H(2)S and acetone gas offer a potential platform for application in diabetes and halitosis diagnosis.
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.
authors.forename: Seon-Jin
authors.initials: SJ
authors.lastname: Choi
authors.forename: Inkun
authors.initials: I
authors.lastname: Lee
authors.forename: Bong-Hoon
authors.initials: BH
authors.lastname: Jang
authors.forename: Doo-Young
authors.initials: DY
authors.lastname: Youn
authors.forename: Won-Hee
authors.initials: WH
authors.lastname: Ryu
authors.forename: Chong Ook
authors.initials: CO
authors.lastname: Park
authors.forename: Il-Doo
authors.initials: ID
authors.lastname: Kim
mesh_terms: D000096:Acetone / Q000737:chemistry*; D001944:Breath Tests / Q000295:instrumentation / Q000379:methods*; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000378:metabolism; D045853:Exhalation / Q000502:physiology; D006801:Humans; D043942:Nanotubes / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D014414:Tungsten / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D010087:Oxides; D000096:Acetone; D010984:Platinum; C511604:tungsten oxide; D014414:Tungsten