title: Breast cancer stem cells: we've got them surrounded.
abstract: Breast cancer stem cells are regulated by cell intrinsic pathways as well as by elements in the tumor microenvironment. New evidence suggests that an important interaction between the interleukin (IL)-8 receptor CXCR1/2 and HER2 is involved in this regulation. Simultaneous targeting of these pathways provides a novel therapeutic approach.
authors.affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. hkorkaya@med.umich.edu
authors.forename: Hasan
authors.initials: H
authors.lastname: Korkaya
authors.forename: Max S
authors.initials: MS
authors.lastname: Wicha
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D023062:Receptors, Interleukin-8A / Q000378:metabolism*; D023063:Receptors, Interleukin-8B / Q000378:metabolism*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B