title: [Effect of Pongamia pinnata root flavonoids on the quality of ulcer healing and expression of EGF and TGF-alpha in the rat model of gastric ulcer induced by acetic acid].
abstract: OBJECTIVE
  To observe the effects and mechanisms of Pongamia pinnata root flavonoids (PRF) on the experimental gastric ulcer induced by acetic acid and to study the mechanism of PRF on the quality of ulcer healing.
  
  
  METHODS
  The models were established by acetic acid erosion, the quality of ulcer healing of PRF on the model of gastric ulcer were observed. The contents of epidermal growth factor (EGF) in serum were determined by radioimmunoassay. The expression of EGF and transforming growth factor-alpha (TGF-alpha) were detected by immunohistochemistry (SP).
  
  
  RESULTS
  PRF significantly inhibited ulcerative formation induced by acetic acid (P < 0.05, P < 0.01). PRF could significantly increase the EGF and TGF-alpha (P < 0.05, P < 0.01) expression of para-ulcer mucosa tissue and improve the EGF contents in blood serum (P < 0.05, P < 0.01).
  
  
  CONCLUSIONS
  PRF increases the contents of EGF in serum and the expression of EGF and TGF-alpha in the tissue around gastric ulcer which might be one of possible mechanisms that PRF improves quality of ulcer healing.
authors.affiliation: Department of Physiology, School of Medicine, Hubei Institute for Nationalities, Enshi 445000, China. liukeyunqiqi@yahoo.com.cn
authors.forename: Ke-Yun
authors.initials: KY
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xian-Zhen
authors.initials: XZ
authors.lastname: Huang
mesh_terms: D019342:Acetic Acid; D000818:Animals; D004815:Epidermal Growth Factor / Q000097:blood*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000378:metabolism*; D008297:Male; D033641:Millettia / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D016211:Transforming Growth Factor alpha / Q000378:metabolism*
chemical_list: D005419:Flavonoids; D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor; D019342:Acetic Acid