title: [Comparative study of IL-4, IFN-gamma gene methylation for the epigenetics of allergic rhinitis in Xinjiang Uygur, Han people].
abstract: OBJECTIVE
  To investigate the differences of IL-4, IFN-gamma gene promoter methylation of allergic rhinitis patients between Uygur and Han people of Xinjiang.
  
  
  METHODS
  Methylation-specific PCR (MSP) detected IL-4, IFN-gamma gene methylation of each of 50 patients with allergic rhinitis in Uygur and Han.
  
  
  RESULTS
  Complete IL-4 gene promoter methylation rate was 44% (22/50) and 48% (24/50) in Uygur and Han AR patients, un-methylation was 26% (13/50) and 22% (11/50), coexistence rate of methylation and un-methylation was 30% (15/50) and 30% (15/50). Complete IFN-gamma gene promoter methylation rate was 12% (6/50) and 16% (8/50) in Uygur and Han AR patients, un-methylation was 8% (4/50) and 10% (5/50), coexistence rate of methylation and unmethylated was 80% (40/50) and 74% (37/50). Distribution of IL-4 gene methylation between Han and Uygur AR patients had no statistically significant (P > 0.05). Distribution of IFN-gamma gene methylation between Han and Uygur AR patients had no statistically significant (P > 0.05).
  
  
  CONCLUSIONS
  There is no difference of IL-4, IFN-gamma gene methylation in patients between the Han and Uygur.
authors.affiliation: Department of Otorhinolaryngology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 230001, China.
authors.forename: Zhongzhang
authors.initials: Z
authors.lastname: Lou
authors.forename: Huiwu
authors.initials: H
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Jiang
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Ni Re
authors.initials: NR
authors.lastname: Mu
authors.forename: He Ta Er
authors.initials: HT
authors.lastname: Mu
authors.forename: Li
authors.initials: L
authors.lastname: Gao
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D008297:Male; D011401:Promoter Regions, Genetic; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology / Q000235:genetics*
chemical_list: D015847:Interleukin-4; D007371:Interferon-gamma