title: VEGF levels and the angiogenic potential of the microenvironment can affect surgical strategy for colorectal liver metastasis.
abstract: The hypotheses emerging from basic research on colorectal liver metastases must be tested in clinical situations for the adaptation of current treatment strategies. Pre-metastatic niches have been shown to exist in human colorectal synchronous metastases, with the liver parenchyma adjacent to the synchronous liver metastases providing a favorable, angiogenic environment for metastatic tumor growth. The role of the VEGF signaling pathway in liver regeneration and tumor growth remains unclear, but the use of antiangiogenic agents in combination with surgical treatment is almost certainly beneficial.
authors.affiliation: INSERM U965 Angiogenesis and Translational Research; Paris-Diderot Paris 7 University, Hôpital Lariboisière, Paris, France.
authors.forename: Clarisse
authors.initials: C
authors.lastname: Eveno
authors.forename: Marc
authors.initials: M
authors.lastname: Pocard
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002465:Cell Movement; D002986:Clinical Trials as Topic; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D003131:Combined Modality Therapy; D042783:Endothelial Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D051798:Inhibitor of Differentiation Protein 1 / Q000235:genetics / Q000378:metabolism; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery*; D008115:Liver Regeneration; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology*; D011183:Postoperative Complications / Q000188:drug therapy / Q000473:pathology; D015398:Signal Transduction; D059016:Tumor Microenvironment; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; C497453:ID1 protein, human; D051798:Inhibitor of Differentiation Protein 1; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2