title: Experimental comparison of the effects of locally administered zoledronic acid and alendronate on the rate of mandibular distraction osteogenesis in dogs.
abstract: OBJECTIVE
  The objective of this study was the evaluation of effects of locally administered zoledronic acid and alendronate on rate of osteogenesis in distracted mandible of dogs.
  
  
  METHODS
  Following mandibular corticotomy, bone segments were maintained in a neutral position by distractor for 7 days then distraction was initiated at a rate of 0.5 mm twice a day for 10 days to achieve a total distraction of 10 mm, followed by a consolidation period. Animals were divided into 3 equal groups according to the injected drug (saline solution [control], zoledronic acid, alendronate). The dogs were killed 2, 6, and 10 weeks following distraction and samples were collected for radiographic examination, assessment of bone mineral density, and histopathological evaluation.
  
  
  RESULTS
  Radiographs and histopathological results pointed out that bone formation and maturation of experimental groups were faster than those of the control group.
  
  
  CONCLUSIONS
  Local administration of zoledronic acid and alendronate proved to be effective in shortening the consolidation period.
authors.affiliation: Lecturer, Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Assiut), Al-Azhar University, Egypt.
authors.forename: Abdel Aziz
authors.initials: AA
authors.lastname: Baiomy
authors.affiliation: Lecturer, Pathology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt. Electronic address: Moh_nassan@yahoo.com.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Nassan
authors.affiliation: Professor of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Cairo), Al-Azhar University, Egypt.
authors.forename: Elsaeed M
authors.initials: EM
authors.lastname: Abdellatif
authors.affiliation: Professor and Head of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Assiut), Al-Azhar University, Egypt.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Abdel Fattah
authors.affiliation: Lecturer, Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Cairo), Al-Azhar University, Egypt.
authors.forename: Ahmed A H
authors.initials: AA
authors.lastname: El-Fekey
authors.affiliation: Professor, Surgery Department, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Zagazig University, Egypt.
authors.forename: Abdel Bassit M
authors.initials: AB
authors.lastname: Abdel Aal
mesh_terms: D015502:Absorptiometry, Photon; D019386:Alendronate / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D015519:Bone Density; D004164:Diphosphonates / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D008334:Mandible / Q000000981:diagnostic imaging / Q000601:surgery*; D010012:Osteogenesis / Q000187:drug effects*; D019857:Osteogenesis, Distraction / Q000379:methods*; D010027:Osteotomy; D011897:Random Allocation; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D019386:Alendronate