title: [Studying change of regional cerebral blood flow after superficial temporal artery-middle cerebral artery anastomosis during acute stage in patients with Moyamoya disease].
abstract: OBJECTIVE
  To explore the changes of regional cerebral blood flow at the site of anastomosis of superficial temporal artery-middle cerebral artery (STA-MCA) to guide the preventive treatment of symptomatic hyperperfusion.
  
  
  METHODS
  A total of 35 patients with Moyamoya disease were recruited from Beijing Tiantan Hospital. There were 22 males and 13 females with an average age of 29 years (range: 5 - 55). And there were 10 children. Regional cortical blood flow (rCBF) was measured by Laser Doppler flowmeter (LDF) before, after and at Day 1, 2, 3, 4, 5 and 6 postoperation of STA-MCA anastomosis. The probe of LDF was implanted adjacent to the area of anastomosis for 144 hours to record the values of rCBF.
  
  
  RESULTS
  The baseline LDF values of cortical rCBF near the area of anastomosis were (69 ± 24) PU before anastomosis, (66 ± 74) PU immediately after anastomosis, (123 ± 23) PU at the conscious time after anesthesia postoperation, (297 ± 17) PU at Day 1 postoperation. And the LDF values of the following 5 days were (302 ± 31), (317 ± 26), (272 ± 46), (363 ± 54) and (367 ± 24) PU respectively.
  
  
  CONCLUSIONS
  As a safe and effective treatment for Moyamoya disease, STA-MCA anastomosis has great risks for symptomatic hyperperfusion. The highest risk time for hyperperfusion is identified after STA-MCA.
authors.affiliation: Department of Neurosurgery, Tibet Autonomous Region Second People's Hospital, Lhasa, China.
authors.forename: Dunzhu
authors.initials: D
authors.lastname: Gesang
authors.forename: Ji-zong
authors.initials: JZ
authors.lastname: Zhao
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: Yuan-li
authors.initials: YL
authors.lastname: Zhao
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000714:Anastomosis, Surgical; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000601:surgery; D009072:Moyamoya Disease / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D012039:Regional Blood Flow; D013699:Temporal Arteries / Q000601:surgery; D016896:Treatment Outcome; D014463:Ultrasonography; D055815:Young Adult