title: Tetratricopeptide repeat motifs in the world of bacterial pathogens: role in virulence mechanisms.
abstract: The tetratricopeptide repeat (TPR) structural motif is known to occur in a wide variety of proteins present in prokaryotic and eukaryotic organisms. The TPR motif represents an elegant module for the assembly of various multiprotein complexes, and thus, TPR-containing proteins often play roles in vital cell processes. As the TPR profile is well defined, the complete TPR protein repertoire of a bacterium with a known genomic sequence can be predicted. This provides a tremendous opportunity for investigators to identify new TPR-containing proteins and study them in detail. In the past decade, TPR-containing proteins of bacterial pathogens have been reported to be directly related to virulence-associated functions. In this minireview, we summarize the current knowledge of the TPR-containing proteins involved in virulence mechanisms of bacterial pathogens while highlighting the importance of TPR motifs for the proper functioning of class II chaperones of a type III secretion system in the pathogenesis of Yersinia, Pseudomonas, and Shigella.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic. cervenyl@faf.cuni.cz
authors.forename: Lukas
authors.initials: L
authors.lastname: Cerveny
authors.forename: Adela
authors.initials: A
authors.lastname: Straskova
authors.forename: Vera
authors.initials: V
authors.lastname: Dankova
authors.forename: Anetta
authors.initials: A
authors.lastname: Hartlova
authors.forename: Martina
authors.initials: M
authors.lastname: Ceckova
authors.forename: Frantisek
authors.initials: F
authors.lastname: Staud
authors.forename: Jiri
authors.initials: J
authors.lastname: Stulik
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics*; D001419:Bacteria / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D014774:Virulence
chemical_list: D001426:Bacterial Proteins