title: [Evaluation of chemoradiotherapy for Stage II and III( non-T4) esophageal cancer].
abstract: OBJECTIVE
  We retrospectively evaluated the clinical efficacy of chemoradiotherapy for surgically resectable Stage II and III (non-T4) esophageal cancer.
  
  
  METHODS
  93 patients were diagnosed with esophageal cancer of clinical stage II and III(non-T4) from April 2005 to December 2010. Among them, 20 patients who were treated with 5-fluorouracil(5-FU) and cisplatin(CDDP) plus 60 Gy extra beam radiation were enrolled in this study.
  
  
  RESULTS
  13 patients(65%) had a complete response (CR), 3 patients had a partial response (PR), and the overall response rate was 80%. Significant statistical differences in lymph node metastasis ratio and clinical stage before chemoradiotherapy were revealed between CR patients and non-CR patients. No statistical differences were observed between surgically-treated cases and chemoradiotherapy cases in overall five-year survival rate and disease-free survival rate. The five-year survival rate of the CR patients (71.6%) was significantly better than that of the non-CR patients(22.2%)( p=0.04).
  
  
  CONCLUSIONS
  Chemoradiotherapy for Stage II and III esophageal cancer appeared to be by no means inferior to esophagectomy and must be a choice during treatment planning.
authors.affiliation: Dept. of Digestive Tract and General Surgery, Saitama Medical University, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Ishiguro
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kumagai
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kumamoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Baba
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Norihiro
authors.initials: N
authors.lastname: Haga
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ishida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy; D004938:Esophageal Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging