title: A Staphylococcus xylosus isolate with a new mecC allotype.
abstract: Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.
authors.affiliation: University of Cambridge, Department of Veterinary Medicine, Cambridge, United Kingdom.
authors.forename: Ewan M
authors.initials: EM
authors.lastname: Harrison
authors.forename: Gavin K
authors.initials: GK
authors.lastname: Paterson
authors.forename: Matthew T G
authors.initials: MT
authors.lastname: Holden
authors.forename: Fiona J E
authors.initials: FJ
authors.lastname: Morgan
authors.forename: Anders Rhod
authors.initials: AR
authors.lastname: Larsen
authors.forename: Andreas
authors.initials: A
authors.lastname: Petersen
authors.forename: Sabine
authors.initials: S
authors.lastname: Leroy
authors.forename: Sarne
authors.initials: S
authors.lastname: De Vliegher
authors.forename: Vincent
authors.initials: V
authors.lastname: Perreten
authors.forename: Lawrence K
authors.initials: LK
authors.lastname: Fox
authors.forename: Theo J G M
authors.initials: TJ
authors.lastname: Lam
authors.forename: Otlis C
authors.initials: OC
authors.lastname: Sampimon
authors.forename: Ruth N
authors.initials: RN
authors.lastname: Zadoks
authors.forename: Sharon J
authors.initials: SJ
authors.lastname: Peacock
authors.forename: Julian
authors.initials: J
authors.lastname: Parkhill
authors.forename: Mark A
authors.initials: MA
authors.lastname: Holmes
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D015373:Bacterial Typing Techniques; D002417:Cattle; D056426:Genetic Loci; D016680:Genome, Bacterial; D006801:Humans; D016106:Methicillin Resistance / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics*; D046915:Penicillin-Binding Proteins; D020033:Protein Isoforms / Q000235:genetics; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013210:Staphylococcus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D046915:Penicillin-Binding Proteins; D020033:Protein Isoforms; C414317:SarH1 protein, Staphylococcus aureus; D014157:Transcription Factors; C487789:mecA protein, Staphylococcus aureus