title: [Effects of human umbilical cord mesenchymal stem cells in the treatment of paraquat-induced lung injury].
abstract: OBJECTIVE
  To evaluate the clinical effect and safety of human umbilical cord mesenchymal stem cells (HUCMSCs) in the treatment of lung injury caused by acute paraquat poisoning.
  
  
  METHODS
  Thirteen patients with lung injury caused by acute paraquat poisoning, who were admitted to Guangzhou No. 12 People's Hospital from December 2008 to December 2012, were divided into HUCMSC group (n = 5) and control group (n = 8). All patients received conventional treatment, while the HUCMSC group was treated with HUCMSCs as an addition. Sequential Organ Failure Assessment (SOFA) system, which was created by the Infection Section of European Society of Intensive Care Medicine, and Acute Physiology and Chronic Health Evaluation II were used to acquire the SOFA scores of patients. The lung injury was evaluated with lung injury score (LIS). The two groups were compared with respect to maximum SOFA scores at 1, 3, 5, 7, 14, and 15 days after paraquat poisoning.
  
  
  RESULTS
  The HUCMSC group showed significantly lower maximum SOFA scores than the control group at 15d after poisoning (1.80 ± 2.05 vs 13.50 ± 7.59, P < 0.05). The LISs of the HUCMSC group after treatment (0.45 ± 0.27) were significantly lower than those of the HUCMSC group before treatment (1.15 ± 0.34) and those of the control group after treatment (2.94 ± 1.20) (P < 0.01). In the HUCMSC group, all patients survived, and they complained no discomfort and showed normal liver, kidney, and lung functions in reexamination; one patient showed incompletely absorbed shadow in the posterior segment of the left lower lobe of the lung during lung CT scan, and no abnormal findings were seen in other patients. In the control group, one patient survived, and others died. No adverse reactions, such as chill and fever, were presented in the HUCMSC group.
  
  
  CONCLUSIONS
  HUCMSCs show promise for clinical application in the treatment of lung injury caused by acute paraquat poisoning.
authors.affiliation: Guangzhou 12th Municipal People's Hospital, Guangzhou 510620, China.
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Jia-yu
authors.initials: JY
authors.lastname: Chen
authors.forename: Geng-xin
authors.initials: GX
authors.lastname: Ye
authors.forename: Yi-ming
authors.initials: YM
authors.lastname: Liu
authors.forename: Lin-zhen
authors.initials: LZ
authors.lastname: Chen
authors.forename: Yun-xian
authors.initials: YX
authors.lastname: Chen
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Xue-yun
authors.initials: XY
authors.lastname: Zhong
mesh_terms: D055371:Acute Lung Injury; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D055370:Lung Injury / Q000139:chemically induced / Q000628:therapy; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D010269:Paraquat / Q000506:poisoning; D011654:Pulmonary Edema / Q000628:therapy*; D016896:Treatment Outcome; D014470:Umbilical Cord / Q000166:cytology; D055815:Young Adult
chemical_list: D010269:Paraquat