title: New sesquiterpenes and phenolic compound from Ficus foveolata.
abstract: Two new eudesmane-type sesquiterpenes, named foveolide A (1) and foveoeudesmenone (2), one new sesquiterpenoid dimer, foveolide B (3) and a new phenolic compound, foveospirolide (4), were isolated along with six known compounds, including 4(15)-eudesmene-1β, 6α-diol (5), 4(15)-eudesmene-1β, 5α-diol (6), friedelin, taraxerol, betulin and ethyl rosmarinate, from the stems of Ficus foveolata. The structures of these new compounds were characterized by spectroscopic methods (IR, MS and NMR). Compound 1 exhibited moderate cytotoxicity against SW620, HepG2, BT474 and KATO-III cancer cell lines, whereas compound 3 was specifically cytotoxic toward SW620 cell line.
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Pathom
authors.initials: P
authors.lastname: Somwong
authors.forename: Rutt
authors.initials: R
authors.lastname: Suttisri
authors.forename: Anumart
authors.initials: A
authors.lastname: Buakeaw
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D030681:Ficus / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane