title: Prognostic significance of serum miR-17-5p in lung cancer.
abstract: miR-17-5p is abnormally expressed in various tumor types. The aim of this study was to investigate the expression level of miR-17-5p in serum of patients with lung cancer and to determine whether serum miR-17-5p expression is related to the prognosis of patients with lung cancer. RT-qPCR was used to examine expression of miRNA-17-5p in 20 pairs of lung cancer and adjacent normal tissues, and sera from 221 patients with lung cancer and 54 matched controls. The correlation of serum miR-17-5p with clinicopathological factors or prognosis of patients with lung cancer was analyzed. The expression level of miR-17-5p obviously increased in lung cancer tissues (P = 0.004). Furthermore, serum miR-17-5p expression also significantly increased in patients with lung cancer compared with healthy individuals (P = 0.03). The survival analysis showed that serum miR-17-5p expression was closely related to the survival of patients with lung cancer. Patients with high miR-17-5p expression had shorter survival times [hazard ratio (HR) = 1.767, 95 %CI 1.039-3.005, P = 0.035]. A lower expression level of serum miR-17-5p helps extend the survival of patients with lung cancer. Thus, miR-17-5p may be potential biomarker for prediction the prognosis in patients with lung cancer.
authors.affiliation: Department of Oncology, Fuzhou Pulmonary Hospital, Fujian Medical University, Fuzhou 350008, China. chenqun88@hotmail.com
authors.forename: Qun
authors.initials: Q
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Si
authors.forename: Song
authors.initials: S
authors.lastname: Xiao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xie
authors.forename: Jiangping
authors.initials: J
authors.lastname: Lin
authors.forename: Chenhui
authors.initials: C
authors.lastname: Wang
authors.forename: Lizhou
authors.initials: L
authors.lastname: Chen
authors.forename: Qiaolin
authors.initials: Q
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000097:blood* / Q000235:genetics* / Q000401:mortality; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; C524941:MIRN17 microRNA, human; D035683:MicroRNAs