title: Sepsis: update in the management.
abstract: Sepsis and septic shock are syndromes that overlap between several disciplines and subspecialties. Emerging evidence suggests that sepsis may be associated with short- and long-term adverse outcomes, even when the syndrome does not appear to be severe and is not managed in the intensive care unit. Hence, all practicing clinicians need to be familiar with the fundamental principles of diagnosis and management of sepsis. In this review, we have summarized the key components in the management of sepsis/septic shock, including early recognition, early resuscitation, principles of antibiotic therapy, organ support, and role of adjunctive therapies.
authors.affiliation: Department of Critical Care Medicine, Apollo Hospitals, Chennai, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Venkataraman
authors.forename: John A
authors.initials: JA
authors.lastname: Kellum
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D003131:Combined Modality Therapy; D042241:Early Diagnosis; D005440:Fluid Therapy; D006801:Humans; D012151:Resuscitation / Q000379:methods; D018805:Sepsis / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D012772:Shock, Septic / Q000175:diagnosis / Q000628:therapy
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D015415:Biomarkers