title: [Skeletal aging].
abstract: Skeletal aging means aging of calcified bone matrix. Although calcification is an essential part of bone formation and its strength, in case of calcium deficiency, calcium is mobilized from bone at the expense of skeletal integrity. The quality as well as quantity of bone matrix is maintained through remodeling activity collaboratively performed by osteoclasts, osteoblasts and osteocytes, and remodeling disorder results in compromised bone strength. Energy homeostasis and vascular system are also closely linked with bone metabolism.
authors.affiliation: National Center for Geriatrics and Gerontology, Japan.
authors.forename: Kyoji
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000375:Aging; D000818:Animals; D001857:Bone Matrix / Q000378:metabolism; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism*; D002113:Calcification, Physiologic / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D006801:Humans
chemical_list: D002118:Calcium