title: Enhancements of skin cell proliferations and migrations via 6-dehydrogingerdione.
abstract: Human skin protects the body from mechanical and chemical damages, and skin wound healing is a costly procedure and worldwide issue. A  Zingiber officinale  compound, 6-dehydrogingerdione (6-DG), is presented as a novel biofunctional healing agent for human skin wound repair. The effectiveness on cell growth/migration, growth factor, collagen amount, and enzymatic activity was assessed. 6-DG treatment accelerated cellular proliferation and migration dose-dependently. Enzyme-linked immunosorbent assay (ELISA) showed that 6-DG brought about higher growth factor productions on transforming growth factor-β (TGF-β), platelet-derived growth factor-αβ (PDGF-αβ), and vascular endothelial growth factors (VEGF). Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion. 6-DG also blocked the mitogen-activated protein kinase (MAPK) pathway by suppressing c-Jun protein levels and extracellular signal-regulated kinases (ERK) phosphorylation in fibroblasts. From all of the above, 6-DG has potential to be a novel agent for human skin repair.
authors.affiliation: School of Medical and Health Sciences, Fooyin University, Kaohsiung 831, Taiwan, ROC.
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Chen
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chiu
authors.forename: Chi-Peng
authors.initials: CP
authors.lastname: Wu
authors.forename: Yi-Ting
authors.initials: YT
authors.lastname: Chou
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Wang
mesh_terms: D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D005233:Fatty Alcohols / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D020939:Zingiber officinale / Q000737:chemistry*; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D012867:Skin / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: C555348:6-dehydrogingerdione; D005233:Fatty Alcohols; D010936:Plant Extracts; D010982:Platelet-Derived Growth Factor; D019715:Tissue Inhibitor of Metalloproteinase-1; D016212:Transforming Growth Factor beta; D006139:Guaiacol