title: Immune responses to West Nile virus infection in the central nervous system.
abstract: West Nile virus (WNV) continues to cause outbreaks of severe neuroinvasive disease in humans and other vertebrate animals in the United States, Europe, and other regions of the world. This review discusses our understanding of the interactions between virus and host that occur in the central nervous system (CNS), the outcome of which can be protection, viral pathogenesis, or immunopathogenesis. We will focus on defining the current state of knowledge of WNV entry, tropism, and host immune response in the CNS, all of which affect the balance between injury and successful clearance.
authors.affiliation: Departments of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. hyelimcho@wustl.edu
authors.forename: Hyelim
authors.initials: H
authors.lastname: Cho
authors.forename: Michael S
authors.initials: MS
authors.lastname: Diamond
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000276:immunology* / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D056189:Viral Tropism; D053586:Virus Internalization; D014901:West Nile Fever / Q000453:epidemiology / Q000662:veterinary; D014902:West Nile virus / Q000276:immunology* / Q000472:pathogenicity*