title: Modulating CD27 signaling to treat cancer.
abstract: CD27 signaling can either improve T-cell function or lead to T-cell dysfunction, depending on the duration and conditions of receptor ligation. Recent studies have shown that modulating the CD70-CD27 interaction is an attractive strategy to treat solid tumors and also to directly target leukemia stem cells.
authors.affiliation: Tumor Immunology; Department of Clinical Research; University of Bern; Bern, Switzerland.
authors.forename: Carsten
authors.initials: C
authors.lastname: Riether
authors.forename: Christian
authors.initials: C
authors.lastname: Schürch
authors.forename: Adrian F
authors.initials: AF
authors.lastname: Ochsenbein