title: Tobacco habits in nocturnal frontal lobe epilepsy.
abstract: The beneficial effect of nicotine has been reported in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) patients, but not tested in sporadic cases. Recently, a nicotine defect in the arousal pathway has been hypothesized even in sporadic NFLE patients and their relatives. This case-control family study was designed to test whether NFLE subjects were more likely to use tobacco than controls, as an indirect marker of cholinergic arousal system dysregulation. At least four relatives were included for each NFLE proband and control. Each subject was questioned about tobacco habits; 434 individuals were recruited. Moreover, we compared NFLE patients with age- and sex-matched controls to determine whether they are more likely to use tobacco. We found a slightly higher trend of tobacco use in NFLE probands compared to that in control subjects; we did not find any significant difference in the distribution of tobacco use among NFLE group compared to that in the control group.
authors.affiliation: IRCCS Istituto delle Scienze Neurologiche Bologna, and Dipartimento di ScienzeBiomediche e NeuroMotorie, Alma Mater Studiorum Università di Bologna, Bologna, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Naldi
authors.forename: Francesca
authors.initials: F
authors.lastname: Bisulli
authors.forename: Luca
authors.initials: L
authors.lastname: Vignatelli
authors.forename: Laura
authors.initials: L
authors.lastname: Licchetta
authors.forename: Francesca
authors.initials: F
authors.lastname: Pittau
authors.forename: Lidia
authors.initials: L
authors.lastname: Di Vito
authors.forename: Barbara
authors.initials: B
authors.lastname: Mostacci
authors.forename: Veronica
authors.initials: V
authors.lastname: Menghi
authors.forename: Federica
authors.initials: F
authors.lastname: Provini
authors.forename: Pasquale
authors.initials: P
authors.lastname: Montagna
authors.forename: Paolo
authors.initials: P
authors.lastname: Tinuper
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology*; D005260:Female; D006184:Habits; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D017286:Polysomnography; D011978:Receptors, Nicotinic / Q000235:genetics; D012189:Retrospective Studies; D014029:Tobacco Use Disorder / Q000453:epidemiology* / Q000523:psychology; D014741:Video Recording; D055815:Young Adult
chemical_list: D011978:Receptors, Nicotinic