title: Phytochemicals: countering risk factors and pathological responses associated with ischaemia reperfusion injury.
abstract: Plant derived non-nutritive molecules, known as phytochemicals, have been investigated for their ability to provide protection against inflammation. Emerging studies of several vasculopathies (e.g. atherosclerosis, hypertension) provide novel data to support these anti-inflammatory effects and offer evidence for involvement of host pathways. Fundamental mechanisms of action are common amongst these compounds, and furthermore, the administration of these phytochemicals activates host defence pathways innately present to protect cells from oxidative stress. This review will elucidate the real benefit of therapeutic intervention with these phytochemicals for vasculopathies, and associated ischaemia reperfusion injury in both the heart and brain.
authors.affiliation: Division of Brain Sciences, Imperial College London, United Kingdom.
authors.forename: Scarlett
authors.initials: S
authors.lastname: Gillespie
authors.forename: Felicity N E
authors.initials: FN
authors.lastname: Gavins
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism; D008517:Phytotherapy; D010944:Plants / Q000737:chemistry; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism; D012307:Risk Factors
chemical_list: D000893:Anti-Inflammatory Agents