title: The longevity of sirtuins.
abstract: Controversy has recently arisen over the role of sirtuins in metazoan aging. In this issue of Cell Reports, Banerjee et al. demonstrate that Drosophila Sir2 is necessary for life span extension in response to dietary restriction and that its overexpression in the fat body increases the life span.
authors.affiliation: Glenn Laboratories for the Molecular Biology of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. david_sinclair@hms.harvard.edu
authors.forename: David
authors.initials: D
authors.lastname: Sinclair
authors.forename: Eric
authors.initials: E
authors.lastname: Verdin
mesh_terms: D000818:Animals; D004032:Diet; D029721:Drosophila Proteins / Q000378:metabolism*; D005216:Fat Body / Q000378:metabolism*; D006655:Histone Deacetylases / Q000378:metabolism*; D008136:Longevity / Q000502:physiology*; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; C447899:Sirt2 protein, Drosophila; D037761:Sirtuins; D006655:Histone Deacetylases