title: Circadian rhythms, metabolism, and insulin sensitivity: transcriptional networks in animal models.
abstract: Homeostatic systems have adapted to respond to the diurnal light/dark cycle. Numerous physiological pathways, including metabolism, are coordinated by this 24-h cycle. Animals with mutations in clock genes show abnormal glucose and lipid metabolism, indicating a critical relationship between the circadian clock and metabolism. Energy homeostasis is achieved through circadian regulation of the expression and activity of several key metabolic enzymes. Temporal organization of tissue metabolism is coordinated by reciprocal cross-talk between the core clock mechanism and key metabolic enzymes and transcriptional activators. The aim of this review is to define the role of the circadian clock in the regulation of insulin sensitivity by describing the interconnection between the circadian clock and metabolic pathways.
authors.affiliation: Biological Systems Control Team, Chemical Biology Project, Research and Development Department, Biomedicinal Information Research Center, National of Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koto-ku, Tokyo, 135-0064, Japan. masashi-kitazawa@aist.go.jp
authors.forename: Masashi
authors.initials: M
authors.lastname: Kitazawa
mesh_terms: D000818:Animals; D057906:Circadian Clocks / Q000502:physiology; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology*; D053858:Metabolic Networks and Pathways / Q000502:physiology; D023421:Models, Animal