title: Pediatric giant cell fibroma: an unusual case report.
abstract: Giant cell fibroma (GCF) is a lesion of oral mucosa which is commonly found on gingiva. The prevalence of GCF is high in Caucasians in the first three decades. It represents 2% to 5% of all fibrous lesions. This report describes a case of GCF on the tongue in a 12 year old Dravidian  child. The cause of the lesion could not be determined. Excisional biopsy was performed to establish definitive diagnosis. Microscopically, numerous stellate shaped multi-nucleated giant cells and dense bundles of collagen fibres with a whorled pattern were observed. These collagen fibres  were positive for Massons trichrome stain. Immunohistochemical analysis showed stellate cells positive for vimentin and negative for alpha smooth muscle actin suggesting fibroblast phenotype. No recurrence was observed. Pediatric dentists must have a thorough knowledge of this uncommon lesion  which can be diagnosed only based on histopathological features.
authors.affiliation: Department of Pediatric Dentistry, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.
authors.forename: K S
authors.initials: KS
authors.lastname: Uloopi
authors.forename: Chandrappa
authors.initials: C
authors.lastname: Vinay
authors.forename: Alluru
authors.initials: A
authors.lastname: Deepika
authors.forename: Rayala Chandra
authors.initials: RC
authors.lastname: Sekhar
authors.forename: Dhanapal
authors.initials: D
authors.lastname: Raghu
authors.forename: Tatapudi
authors.initials: T
authors.lastname: Ramesh
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D024022:Fibrillar Collagens; D005350:Fibroma / Q000473:pathology* / Q000601:surgery; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D007194:India; D014062:Tongue Neoplasms / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000032:analysis
chemical_list: D024022:Fibrillar Collagens; D014746:Vimentin