title: Analysis of fetal and maternal results from fetal genetic invasive procedures: an exploratory study at a University Hospital.
abstract: OBJECTIVE
  To characterize the indications of pregnant women who sought the Fetal Medicine Services of the Hospital das Clínicas, at the Medical School of the Universidade de São Paulo for performing invasive diagnostic procedures, and to evaluate the results of fetal karyotypes and their pregnancies.
  
  
  METHODS
  A retrospective and observational study on pregnant women who underwent chorionic villus sampling (CVS), amniocentesis, and cordocentesis in the period from February, 2005 to December, 2009. Other diagnostic or therapeutic procedures were not included. The result of pregnancy was obtained by consulting patient electronic records, medical records, and/or telephone call.
  
  
  RESULTS
  713 procedures were performed (113 CVS, 340 amniocenteses, and 260 cordocenteses). The main indication for performing invasive procedures was the presence of structural changes in fetuses, followed by increased values of nuchal translucency, and advanced maternal age. Fetal karyotype was altered in 186 cases (26.1%). The 18 trisomy was the commonest aneuploidy followed by the 21 trisomy, X monosomy, and 13 trisomy. There were 4.9% cases of miscarriage, 25.7% cases of stillborn infants, and 13% cases of neonatal deaths. Eight pregnant women opted for legally induced abortion. 99% of pregnant women whose fetuses did not present abnormalities and presented normal fetal karyotype had infants who were born alive.
authors.affiliation: Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Mario
authors.initials: M
authors.lastname: Kohatsu
authors.forename: Mário Henrique Burlacchini de
authors.initials: MH
authors.lastname: Carvalho
authors.forename: Rossana Pulcineli
authors.initials: RP
authors.lastname: Vieira Francisco
authors.forename: Antônio Gomes de
authors.initials: AG
authors.lastname: Amorim Filho
authors.forename: Marcelo
authors.initials: M
authors.lastname: Zugaib
mesh_terms: D000293:Adolescent; D000328:Adult; D000649:Amniocentesis / Q000592:standards; D015193:Chorionic Villi Sampling / Q000592:standards; D017218:Cordocentesis / Q000592:standards; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000235:genetics*; D005333:Fetus / Q000002:abnormalities*; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D008423:Maternal Age; D008875:Middle Aged; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D050497:Stillbirth; D055815:Young Adult