title: Fluevirosines A-C: a biogenesis inspired example in the discovery of new bioactive scaffolds from Flueggea virosa.
abstract: Biogenesis inspired chemical investigation of a Chinese folk medicine, Flueggea virosa, returned three unprecedented C,C-linked trimeric Securinega alkaloids, fluevirosines A-C (1-3). Their absolute structures were characterized on the basis of spectroscopic data and computational analysis. Compounds 2 and 3 showed inhibition against the splicing of XBP1 mRNA.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Chuan-Rui
authors.initials: CR
authors.lastname: Zhang
authors.forename: Kong-Kai
authors.initials: KK
authors.lastname: Zhu
authors.forename: An-Hui
authors.initials: AH
authors.lastname: Gao
authors.forename: Cheng
authors.initials: C
authors.lastname: Luo
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019665:Euphorbiaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012333:RNA, Messenger / Q000187:drug effects*
chemical_list: D000470:Alkaloids; D012333:RNA, Messenger; C580949:fluevirosine A; C580951:fluevirosine B; C580950:fluevirosine C