title: Metabolic effects of Roux-en-Y gastric bypass in obese adolescents and young adults.
abstract: Weight loss surgery is an increasingly common treatment option for obese adolescents, but data are limited regarding the metabolic effects of surgical weight loss procedures. We performed a retrospective review of the electronic medical record to determine metabolic outcomes for 24 adolescents and young adults ages 15 to 22 years undergoing Roux-en-Y gastric bypass from 2009 to 2011 as well as 24 age-, sex-, and BMI-matched controls. During a median follow-up of 6 months after Roux-en-Y gastric bypass, fasting glucose, hemoglobin A1c, low-density lipoprotein, triglyceride, and high-sensitivity C-reactive protein decreased significantly. Changes in these measures were not significantly associated with age or extent of weight loss.
authors.affiliation: Pediatric Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Manasi
authors.initials: M
authors.lastname: Sinha
authors.forename: Takara L
authors.initials: TL
authors.lastname: Stanley
authors.forename: Jessica
authors.initials: J
authors.lastname: Webb
authors.forename: Christina
authors.initials: C
authors.lastname: Scirica
authors.forename: Kathleen
authors.initials: K
authors.lastname: Corey
authors.forename: Janey
authors.initials: J
authors.lastname: Pratt
authors.forename: Paul A
authors.initials: PA
authors.lastname: Boepple
authors.forename: Alison
authors.initials: A
authors.lastname: Hoppin
authors.forename: Madhusmita
authors.initials: M
authors.lastname: Misra
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D015390:Gastric Bypass; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood* / Q000601:surgery; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D002097:C-Reactive Protein; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D008055:Lipids; D014280:Triglycerides