title: Protein kinase Cγ antibodies and paraneoplastic cerebellar degeneration.
abstract: Onconeural antibodies are diagnostic markers for paraneoplastic neurological syndromes and indicate the underlying tumor type. Recently, a new antibody against protein-kinase Cγ (PKCγ) was detected in a patient with paraneoplastic cerebellar degeneration (PCD). We report here a second patient. A 70-year-old woman presented with cerebellar ataxia, dysdiadochokinesia, and dysarthria. Her serum showed immunoreactivity against the cytoplasm, dendrites and axons of Purkinje cells in tissue-based screening, later confirmed by immunoblot and phage plaques as anti-PKCγ. Tumor search revealed an adenocarcinoma of hepatobiliary origin. Detection of PKCγ antibodies should be considered in PCD and adenocarcinoma without typical onconeural antibodies.
authors.affiliation: Service of Neurology, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; Institut d´Investigació Biomèdica August Pi i Suyer (IDIBAPS), Barcelona, Spain.
authors.forename: Romana
authors.initials: R
authors.lastname: Höftberger
authors.forename: Gabor G
authors.initials: GG
authors.lastname: Kovacs
authors.forename: Lidia
authors.initials: L
authors.lastname: Sabater
authors.forename: Peter
authors.initials: P
authors.lastname: Nagy
authors.forename: Gergely
authors.initials: G
authors.lastname: Racz
authors.forename: Rosa
authors.initials: R
authors.lastname: Miquel
authors.forename: Josep
authors.initials: J
authors.lastname: Dalmau
authors.forename: Francesc
authors.initials: F
authors.lastname: Graus
mesh_terms: D000368:Aged; D000818:Animals; D000906:Antibodies / Q000097:blood*; D005260:Female; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D053554:Keratin-20 / Q000378:metabolism; D020362:Paraneoplastic Cerebellar Degeneration / Q000097:blood* / Q000276:immunology / Q000473:pathology; D011493:Protein Kinase C / Q000276:immunology*; D011689:Purkinje Cells / Q000378:metabolism; D051381:Rats
chemical_list: D000906:Antibodies; D053554:Keratin-20; C087857:protein kinase C gamma; D011493:Protein Kinase C