title: Synthesis, crystal structure and antidiabetic activity of substituted (E)-3-(Benzo [d]thiazol-2-ylamino) phenylprop-2-en-1-one.
abstract: A novel series of substituted (E)-3-(Benzo [d]thiazol-2-ylamino)phenylprop-2-en-1-onewere synthesized starting from 2-aminobenzothiazole and 1-aryl-3,3-bis- (methylsulfanyl)-2-propen-1-onesin the presence of a catalytic amount of sodium hydride in THF. The synthesised compounds' structures were confirmed by IR, Mass spectrometry, (1)H NMR, (13)C NMR and HRMS spectral data. These compounds were evaluated for their antidiabetic activity, and most of the derivatives of (E)-3-(Benzo [d]thiazol-2-ylamino)phenylprop-2-en-1-one displayed significant antidiabetic activity.
authors.affiliation: Department of Organic Chemistry, North Maharashtra University, Jalgaon 425001, India.
authors.forename: Vijay S
authors.initials: VS
authors.lastname: Patil
authors.forename: Kamalakar P
authors.initials: KP
authors.lastname: Nandre
authors.forename: Sougata
authors.initials: S
authors.lastname: Ghosh
authors.forename: Vaidya Jayathirtha
authors.initials: VJ
authors.lastname: Rao
authors.forename: Balu A
authors.initials: BA
authors.lastname: Chopade
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Sridhar
authors.forename: Sheshanath V
authors.initials: SV
authors.lastname: Bhosale
authors.forename: Sidhanath V
authors.initials: SV
authors.lastname: Bhosale
mesh_terms: D000681:Amylases / Q000037:antagonists & inhibitors; D000818:Animals; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004789:Enzyme Activation / Q000187:drug effects; D005959:Glucosidases / Q000037:antagonists & inhibitors; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D011427:Propiophenones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013552:Swine
chemical_list: D052160:Benzothiazoles; D007004:Hypoglycemic Agents; D011427:Propiophenones; D000681:Amylases; D005959:Glucosidases