title: Interleukin-18 induces insulin resistance in the hyperthyroid state.
abstract: We previously reported that serum interleukin-18 (IL-18) levels were significantly increased in hyperthyroid Graves' disease patients. The development of insulin resistance in hyperthyroidism has been documented. We investigated the relationship between IL-18 and insulin resistance in patients with hyperthyroid Graves' disease and in experimental hyperthyroid mice. Then, we examined whether IL-18 induces insulin resistance in mice injected with IL-18 for a week. A significant positive correlation was observed between serum IL-18 levels and parameters such as thyroid functions and homeostasis model assessment for insulin resistance in hyperthyroid Graves' disease. In experimental hyperthyroid mice, IL-18 was significantly elevated. Insulin resistance increased in experimental hyperthyroid mice and IL-18-injected mice. These findings suggest IL-18 to be an important factor inducing insulin resistance in hyperthyroidism.
authors.affiliation: Department of Internal Medicine, Uwajima City Hospital, Uwajima, Ehime 798-8510, Japan. syozo@uwajima-mh.jp
authors.forename: Shozo
authors.initials: S
authors.lastname: Miyauchi
authors.forename: Bunzo
authors.initials: B
authors.lastname: Matsuura
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Ueda
authors.forename: Tohru
authors.initials: T
authors.lastname: Eguchi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tamaru
authors.forename: Shin
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Teruki
authors.initials: T
authors.lastname: Miyake
authors.forename: Shinya
authors.initials: S
authors.lastname: Furukawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D013956:Antithyroid Agents / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006111:Graves Disease / Q000097:blood* / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced / Q000209:etiology* / Q000517:prevention & control; D007274:Injections, Intraperitoneal; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020382:Interleukin-18 / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects; D055815:Young Adult
chemical_list: D013956:Antithyroid Agents; D001786:Blood Glucose; D007328:Insulin; D020382:Interleukin-18; D011994:Recombinant Proteins; D008713:Methimazole