title: Dual action spirobicycloimidazolidine-2,4-diones: antidiabetic agents and inhibitors of aldose reductase-an enzyme involved in diabetic complications.
abstract: The desired 3-(arylsulfonyl)spiroimidazolidine-2,4-diones were synthesized by reacting spiroiminoimidazolidine-2,4-dione with arylsulfonyl chlorides. Spiroimidazolidine-2,4-dione was in turn synthesized from norcamphor. Structures of the synthesized molecules were established by modern spectroscopic techniques. The synthesized compounds were screened for in vivo antidiabetic activity and aldose reductase inhibition. Compounds 2a, 2b and 2g exhibited excellent dual activity, compound 2a being most prominent. These results reveal that the synthesized compounds may serve as the molecule of choice to treat diabetes and diabetic complications using a single medication.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Zafar
authors.initials: Z
authors.lastname: Iqbal
authors.forename: Sher
authors.initials: S
authors.lastname: Ali
authors.forename: Jamshed
authors.initials: J
authors.lastname: Iqbal
authors.forename: Qamar
authors.initials: Q
authors.lastname: Abbas
authors.forename: Irfan Zia
authors.initials: IZ
authors.lastname: Qureshi
authors.forename: Shahid
authors.initials: S
authors.lastname: Hameed
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D048909:Diabetes Complications / Q000201:enzymology*; D003920:Diabetes Mellitus / Q000188:drug therapy*; D003921:Diabetes Mellitus, Experimental; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50
chemical_list: D001786:Blood Glucose; D006827:Hydantoins; D007004:Hypoglycemic Agents; D000449:Aldehyde Reductase