title: Multi-marker network in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: when and what to measure.
abstract: BACKGROUND
  Data on the correlations between biomarkers to suggest cost-effective multi-marker (MM) panels predictive for ST-elevation myocardial infarction (STEMI) patients are lacking. We sought to explore the relationship between cardiac troponin I (cTnI), C-reactive protein (CRP), B-type natriuretic peptide (BNP), and chromogranin A (CgA) accounting for biomarkers' profiles detected within 48h from successful primary percutaneous coronary intervention (PPCI).
  
  
  METHODS
  In 73 STEMI patients cTnI, CRP, BNP, and CgA were measured before PPCI and 6, 24, and 48h later. STATIS methods generalizing Principal Component Analysis on three-way data sets were employed to extract information about: 1) similarities between patients, 2) contribution of each time of sampling and 3) correlations between biomarkers' profiles.
  
  
  RESULTS
  STEMI patients who underwent successful PPCI emerged to have a homogeneous profile tailored on biomarkers' evaluation within 48h. Their measurements at 24h contributed the most variability and information both to patients' and to biomarkers' profiles. BNP and cTnI were highly correlated and explained the 40.1% of the total variance, whereas CgA resulted independent and explained the 26.3% of the total variance.
  
  
  CONCLUSIONS
  Markers' measurements at 24h after PPCI contributed most information to the definition of patients' profile. BNP and cTnI resulted interchangeable in a MM panel for reporting about the extent of necrosis.
authors.affiliation: Cattedra di Biochimica Clinica e Biologia Molecolare Clinica, Dipartimento di Scienze Biomediche e Cliniche Luigi Sacco, Università degli Studi, Milano, Italy. ferraro.simona@hsacco.it
authors.forename: Simona
authors.initials: S
authors.lastname: Ferraro
authors.forename: Ilaria
authors.initials: I
authors.lastname: Ardoino
authors.forename: Niccolò
authors.initials: N
authors.lastname: Bassani
authors.forename: Matteo
authors.initials: M
authors.lastname: Santagostino
authors.forename: Lidia
authors.initials: L
authors.lastname: Rossi
authors.forename: Elia
authors.initials: E
authors.lastname: Biganzoli
authors.forename: Angelo S
authors.initials: AS
authors.lastname: Bongo
authors.forename: Mauro
authors.initials: M
authors.lastname: Panteghini
mesh_terms: D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis / Q000379:methods*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000503:physiopathology / Q000601:surgery*; D062645:Percutaneous Coronary Intervention; D025341:Principal Component Analysis; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D015415:Biomarkers