title: [Risk factors associated with stress ulcer bleeding in postoperative rectal cancer patients].
abstract: OBJECTIVE
  To explore the influence factor of stress ulcer bleeding(SUB) in postoperative rectal cancer patients.
  
  
  METHODS
  Clinical data of rectal cancer patients undergoing operation in our hospital were analyzed retrospectively. Patients were  divided into case group and control group according to the postoperative occurrence of SUB. Univariate analysis combined with multivariate analysis were used to evaluate the influence factors.
  
  
  RESULTS
  Chronic diseases incidence of case group was higher than that of control group. Except for renal failure, the incidence of postoperative complications of case group was higher than that of control group. Univariate analysis revealed that age, chronic disease, preoperative, and postoperative complications had statistical significant differences(P<0.05). Multivariate analysis identified that age(OR=2.893, 95%CI:1.118-5.543), drinking history(OR=3.839, 95%CI:1.012-6.654), preoperative chronic disease(OR=4.646, 95%CI:1.872-8.892), intraoperative bleeding volume(OR=5.129, 95%CI:2.829-9.328), occurrence of severe complications after surgery(OR=6.576, 95%CI:4.539-13.278), postoperative application of glucocorticoid(OR=2.978, 95%CI:1.013-4.512), preoperative application of non-steroidal anti-inflammatory drugs(OR=2.126, 95%CI:1.287-7.636) were risk factors for SUB in rectal cancer patients after operation. Postoperative prophylactic use antacids(OR=0.102, 95%CI:0.017-0.196) was protective factor for SUB patients.
  
  
  CONCLUSIONS
  Effective measures should be taken for high-risk patients, in order to improve the prognosis of  patients.
authors.affiliation: Department of Colorectal Surgery, Tianjin Union Medicine Centre, Tianjin, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Shi
authors.forename: Xi-peng
authors.initials: XP
authors.lastname: Zhang
authors.forename: Pei-da
authors.initials: PD
authors.lastname: Zhang
mesh_terms: D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006801:Humans; D015994:Incidence; D009017:Morbidity; D015999:Multivariate Analysis; D011183:Postoperative Complications; D011184:Postoperative Period; D011379:Prognosis; D012004:Rectal Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors; D014456:Ulcer / Q000209:etiology*