title: [Prognostic analysis of 280 patients with T4a gastric cancer who underwent curative resection].
abstract: OBJECTIVE
  To evaluate the predicators of survival and recurrence after curative resection for gastric cancer patients with serosal invasion.
  
  
  METHODS
  Clinical and follow-up data of 280 patients with T4a gastric cancer(according to the 7th UICC TNM Classification for gastric cancer) who underwent curative resection for gastric cancer between January 1997 and December 2003 were analyzed retrospectively.
  
  
  RESULTS
  Five-year survival rate of these 280 patients was 50.0% and 158 patients (56.4%) presented with recurrence after surgery. The 3-year disease-free survival rate was 57.5%. The number of lymph node metastasis and metastatic lymph node ratio(MLR) were identified as the independent predicators for overall survival(P<0.05). The extent of lymph node metastasis was identified as the independent predicators for disease free survival (P<0.05). The extent of lymph node metastasis, the number of lymph node metastasis, and MLR were identified as the independent predicators for recurrence after surgery(P<0.05).
  
  
  CONCLUSIONS
  The number of lymph node metastases, extent of lymph node metastasis and MLR are independent predictors of overall survival and recurrence in T4a gastric cancer patients after curative resection.
authors.affiliation: Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
authors.forename: Wei-feng
authors.initials: WF
authors.lastname: Gao
authors.forename: Han
authors.initials: H
authors.lastname: Liang
authors.forename: Jing-yu
authors.initials: JY
authors.lastname: Deng
authors.forename: Dian-chang
authors.initials: DC
authors.lastname: Wang
authors.forename: Ru-peng
authors.initials: RP
authors.lastname: Zhang
mesh_terms: D018572:Disease-Free Survival; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000601:surgery; D015996:Survival Rate