title: Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle.
abstract: The lipoprotein lipase (LPL) gene can be considered a functional candidate gene that regulates fatty acid composition. In this study, genetic associations between fatty acid composition and exonic single nucleotide polymorphisms (SNPs) in the LPL gene were examined using 612 Korean cattle. We investigated the relationship between unsaturated fatty acids and five novel SNPs (c.322G>A, c.329A>T, c.527T>G, c.988C>T and c.1591G>A), and confirmed that three polymorphic SNPs (c.322G>A, c.329A>T and c.1591G>A) were associated with fatty acid composition. Korean cattle with an AA genotype of c.322G>A, c.329A>T, and GA genotype of c.1591G>A had higher levels of monounsaturated fatty acids and carcass traits (P < 0.05). Our findings confirmed that three novel SNPs we identified in the LPL gene can affect fatty acid composition and carcass traits. Therefore, selection for AA and GA genotypes should be recommended to genetically improve beef quality and flavor.
authors.affiliation: School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, South Korea. moocic@hanmail.net
authors.forename: Dongyep
authors.initials: D
authors.lastname: Oh
authors.forename: Boomi
authors.initials: B
authors.lastname: La
authors.forename: Yoonseok
authors.initials: Y
authors.lastname: Lee
authors.forename: Younhwa
authors.initials: Y
authors.lastname: Byun
authors.forename: Jeayoung
authors.initials: J
authors.lastname: Lee
authors.forename: Geunhye
authors.initials: G
authors.lastname: Yeo
authors.forename: Jungsou
authors.initials: J
authors.lastname: Yeo
mesh_terms: D000818:Animals; D002417:Cattle; D005091:Exons; D005227:Fatty Acids / Q000737:chemistry / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D008071:Lipoprotein Lipase / Q000235:genetics*; D008460:Meat; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide
chemical_list: D005227:Fatty Acids; D008071:Lipoprotein Lipase