title: Real-time PCR quantification of Methanobrevibacter oralis in periodontitis.
abstract: A real-time PCR assay developed to quantify Methanobrevibacter oralis indicated that its inoculum significantly correlated with periodontitis severity (P = 0.003), despite a nonsignificant difference in prevalence between controls (3/10) and patients (12/22) (P = 0.2, Fisher test). The M. oralis load can be used as a biomarker for periodontitis.
authors.affiliation: Aix Marseille Université, URMITE, UMR63 CNRS 7278, IRD 198, Inserm 1095, Marseille, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Bringuier
authors.forename: Saber
authors.initials: S
authors.lastname: Khelaifia
authors.forename: Hervé
authors.initials: H
authors.lastname: Richet
authors.forename: Gérard
authors.initials: G
authors.lastname: Aboudharam
authors.forename: Michel
authors.initials: M
authors.lastname: Drancourt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058491:Bacterial Load / Q000379:methods*; D015415:Biomarkers; D005260:Female; D006801:Humans; D008297:Male; D041581:Methanobrevibacter / Q000302:isolation & purification*; D008875:Middle Aged; D010518:Periodontitis / Q000382:microbiology* / Q000473:pathology; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods*; D012720:Severity of Illness Index; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers