title: Age-specific distributions of cytogenetic subgroups of acute myeloid leukemia: data analysis in a Chinese population.
abstract: Although some studies have reported relationships between cytogenetic subgroups, molecular markers and age in acute myeloid leukemia (AML), conclusions based on data from a Chinese population are lacking. In the present study, we evaluated 640 patients with de novo AML. The patients were divided into 8 age groups, i.e. 0-9, 10-19, 20-29, 30-39, 40-49, 50-59, 60-69 and ≥70 years, and were then classified into cytogenetic groups based on normal, balanced and unbalanced karyotypes.
authors.affiliation: Cancer Center, The First Hospital, Jilin University, Changchun, China.
authors.forename: Long
authors.initials: L
authors.lastname: Su
authors.forename: Sujun
authors.initials: S
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Yehui
authors.initials: Y
authors.lastname: Tan
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Ziling
authors.initials: Z
authors.lastname: Liu
authors.forename: Ou
authors.initials: O
authors.lastname: Bai
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Cheng
authors.initials: C
authors.lastname: Yao
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Song
authors.forename: Guanjun
authors.initials: G
authors.lastname: Wang
mesh_terms: D059786:Abnormal Karyotype; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism*; D000090243:Nucleophosmin; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D051941:fms-Like Tyrosine Kinase 3 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; D000090243:Nucleophosmin; C497970:FLT3 protein, human; D019009:Proto-Oncogene Proteins c-kit; D051941:fms-Like Tyrosine Kinase 3