title: Reprogramming cellular events by poly(ADP-ribose)-binding proteins.
abstract: Poly(ADP-ribosyl)ation is a posttranslational modification catalyzed by the poly(ADP-ribose) polymerases (PARPs). These enzymes covalently modify glutamic, aspartic and lysine amino acid side chains of acceptor proteins by the sequential addition of ADP-ribose (ADPr) units. The poly(ADP-ribose) (pADPr) polymers formed alter the physico-chemical characteristics of the substrate with functional consequences on its biological activities. Recently, non-covalent binding to pADPr has emerged as a key mechanism to modulate and coordinate several intracellular pathways including the DNA damage response, protein stability and cell death. In this review, we describe the basis of non-covalent binding to pADPr that has led to the emerging concept of pADPr-responsive signaling pathways. This review emphasizes the structural elements and the modular strategies developed by pADPr-binding proteins to exert a fine-tuned control of a variety of pathways. Poly(ADP-ribosyl)ation reactions are highly regulated processes, both spatially and temporally, for which at least four specialized pADPr-binding modules accommodate different pADPr structures and reprogram protein functions. In this review, we highlight the role of well-characterized and newly discovered pADPr-binding modules in a diverse set of physiological functions.
authors.affiliation: Centre de recherche du CHUQ - Pavillon CHUL - Cancer Axis, Laval University, Québec, QC, Canada G1V 4G2.|Genome Stability Laboratory, Laval University Cancer Research Center, Hôtel-Dieu de Québec, Québec, QC, Canada G1R 2J6.
authors.forename: Jana
authors.initials: J
authors.lastname: Krietsch
authors.affiliation: Centre de recherche du CHUQ - Pavillon CHUL - Cancer Axis, Laval University, Québec, QC, Canada G1V 4G2.|Department of Molecular Biology, Cellular Biochemistry and Pathology, Faculty of Medicine, Laval University, Québec, QC, Canada G1V 0A6.
authors.forename: Michèle
authors.initials: M
authors.lastname: Rouleau
authors.affiliation: Centre de recherche du CHUQ - Pavillon CHUL - Cancer Axis, Laval University, Québec, QC, Canada G1V 4G2.
authors.forename: Émilie
authors.initials: É
authors.lastname: Pic
authors.affiliation: Centre de recherche du CHUQ - Pavillon CHUL - Cancer Axis, Laval University, Québec, QC, Canada G1V 4G2.
authors.forename: Chantal
authors.initials: C
authors.lastname: Ethier
authors.affiliation: Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Ted M
authors.initials: TM
authors.lastname: Dawson
authors.affiliation: Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Valina L
authors.initials: VL
authors.lastname: Dawson
authors.affiliation: Genome Stability Laboratory, Laval University Cancer Research Center, Hôtel-Dieu de Québec, Québec, QC, Canada G1R 2J6.|Department of Molecular Biology, Cellular Biochemistry and Pathology, Faculty of Medicine, Laval University, Québec, QC, Canada G1V 0A6.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Masson
authors.affiliation: Centre de recherche du CHUQ - Pavillon CHUL - Cancer Axis, Laval University, Québec, QC, Canada G1V 4G2.|Department of Molecular Biology, Cellular Biochemistry and Pathology, Faculty of Medicine, Laval University, Québec, QC, Canada G1V 0A6.
authors.forename: Guy G
authors.initials: GG
authors.lastname: Poirier
authors.affiliation: Centre de recherche du CHUQ - Pavillon CHUL - Cancer Axis, Laval University, Québec, QC, Canada G1V 4G2.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Gagné
mesh_terms: D000818:Animals; D001665:Binding Sites; D004249:DNA Damage; D006801:Humans; D011064:Poly Adenosine Diphosphate Ribose / Q000737:chemistry / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D016335:Zinc Fingers
chemical_list: D011506:Proteins; C024857:poly(ADP)-ribosylated proteins; D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases