title: Pleurodesis with a 50% glucose solution in patients with spontaneous pneumothorax in whom an operation is contraindicated.
abstract: OBJECTIVE
  Pleurodesis continues to play a central role in the management of pneumothorax. In our institute, a 50% glucose solution is used for pleurodesis. We retrospectively analysed the treatment effects of pleurodesis in patients with spontaneous pneumothorax in whom an operation was contraindicated because of underlying disease.
  
  
  METHODS
  13 patients (18 cases) with spontaneous pneumothorax were treated with pleurodesis with a 50% glucose solution. After local anesthesia of parietal pleura, 200 to500 mL of a 50% glucose solution was instilled into the pleural space. Pleurodesis was repeated two or three times, until the air leakage stopped.
  
  
  RESULTS
  Air leakage stopped in all cases and there were no treatment-related deaths.Overall survival rates at 1, 2, and 3 years after treatment were 83%, 74%, and 49%, respectively. Post-treatment recurrence was observed in six cases. Four cases of recurrence were treated with pleurodesis with a 50% glucose solution. All cases of recurrence occurred within 3 months after pleurodesis.
  
  
  CONCLUSIONS
  Pleurodesis with a 50% glucose solution is effective and safe in patients with pneumothorax. This procedure can be performed in patients with recurrent pneumothorax as well as patients with a first episode of pneumothorax in whom prolonged air leakage is predicted.
authors.affiliation: Department of Thoracic Surgery, Bell Land General Hospital, Sakai, Osaka, Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Tsukioka
authors.forename: Kiyotoshi
authors.initials: K
authors.lastname: Inoue
authors.forename: Hiroko
authors.initials: H
authors.lastname: Oka
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Mizuguchi
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Morita
authors.forename: Noritoshi
authors.initials: N
authors.lastname: Nishiyama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000772:Anesthesia, Local; D000075202:Contraindications; D018572:Disease-Free Survival; D005260:Female; D005947:Glucose / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D018700:Pleurodesis / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D011030:Pneumothorax / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D012008:Recurrence; D012189:Retrospective Studies; D012996:Solutions; D015996:Survival Rate; D019616:Thoracic Surgical Procedures; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D012996:Solutions; D005947:Glucose