title: Nutritional and chemical composition and antiviral activity of cultivated seaweed Sargassum naozhouense Tseng et Lu.
abstract: Sargassum naozhouense is a brown seaweed used in folk medicine and applied for thousands of years in Zhanjiang, Guangdong province, China. This study is the first time to investigate its chemical composition and antiviral activity. On the dry weight basis, this seaweed was constituted of ca. 35.18% ash, 11.20% protein, 1.06% lipid and 47.73% total carbohydrate, and the main carbohydrate was water-soluble polysaccharide. The protein analysis indicated the presence of essential amino acids, which accounted for 36.35% of the protein. The most abundant fatty acids were C14:0, C16:0, C18:1 and C20:4. The ash fraction analysis indicated that essential minerals and trace elements, such as Fe, Zn and Cu, were present in the seaweed. IR analysis revealed that polysaccharides from cultivated S. naozhouense may be alginates and fucoidan. The polysaccharides possessed strong antiviral activity against HSV-1 in vitro with EC(50) of 8.92 μg/mL. These results demonstrated cultivated S. naozhouense has a potential for its use in functional foods and antiviral new drugs.
authors.affiliation: Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. py00_2006@126.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Peng
authors.forename: Enyi
authors.initials: E
authors.lastname: Xie
authors.forename: Kai
authors.initials: K
authors.lastname: Zheng
authors.forename: Mangaladoss
authors.initials: M
authors.lastname: Fredimoses
authors.forename: Xianwen
authors.initials: X
authors.lastname: Yang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Zhou
authors.forename: Yifei
authors.initials: Y
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Xiuping
authors.initials: X
authors.lastname: Lin
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D002681:China; D002522:Chlorocebus aethiops; D005227:Fatty Acids / Q000737:chemistry; D008903:Minerals / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D011134:Polysaccharides / Q000737:chemistry; D044647:Sargassum / Q000737:chemistry*; D012624:Seaweed / Q000737:chemistry*; D014709:Vero Cells
chemical_list: D000596:Amino Acids; D000998:Antiviral Agents; D005227:Fatty Acids; D008903:Minerals; D010936:Plant Extracts; D011134:Polysaccharides