title: Asymmetric synthesis of α-alkylidene-β-hydroxy-γ-butyrolactones via enantioselective tandem Michael-aldol reaction.
abstract: A simple and efficient method for the asymmetric synthesis of α-alkylidene-β-hydroxy-γ-butyrolactones and related natural products was developed on the basis of the catalytic asymmetric tandem Michael-aldol reaction and simple transformations. The synthetic utility of this method was illustrated by the facile synthesis of trisubstituted γ-butyrolactone natural products.
authors.affiliation: Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Sung Il
authors.initials: SI
authors.lastname: Lee
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Jang
authors.forename: Geum-Sook
authors.initials: GS
authors.lastname: Hwang
authors.forename: Do Hyun
authors.initials: DH
authors.lastname: Ryu
mesh_terms: D015107:4-Butyrolactone / Q000138:chemical synthesis* / Q000737:chemistry; D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D001688:Biological Products; D015107:4-Butyrolactone