title: Birth-death skyline plot reveals temporal changes of epidemic spread in HIV and hepatitis C virus (HCV).
abstract: Phylogenetic trees can be used to infer the processes that generated them. Here, we introduce a model, the bayesian birth-death skyline plot, which explicitly estimates the rate of transmission, recovery, and sampling and thus allows inference of the effective reproductive number directly from genetic data. Our method allows these parameters to vary through time in a piecewise fashion and is implemented within the BEAST2 software framework. The method is a powerful alternative to the existing coalescent skyline plot, providing insight into the differing roles of incidence and prevalence in an epidemic. We apply this method to data from the United Kingdom HIV-1 epidemic and Egyptian hepatitis C virus (HCV) epidemic. The analysis reveals temporal changes of the effective reproductive number that highlight the effect of past public health interventions.
authors.affiliation: Department of Environmental Systems Science, Eidgenössische Technische Hochschule Zürich, 8092 Zürich, Switzerland. tanja.stadler@env.ethz.ch
authors.forename: Tanja
authors.initials: T
authors.lastname: Stadler
authors.forename: Denise
authors.initials: D
authors.lastname: Kühnert
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bonhoeffer
authors.forename: Alexei J
authors.initials: AJ
authors.lastname: Drummond
mesh_terms: D001499:Bayes Theorem; D004534:Egypt / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission; D015497:HIV-1 / Q000235:genetics*; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000453:epidemiology* / Q000635:transmission; D015994:Incidence; D008957:Models, Genetic; D010802:Phylogeny; D015995:Prevalence; D012984:Software; D006113:United Kingdom / Q000453:epidemiology