title: Treatment for Uterine Fibroids: Searching for Effective Drug Therapies.
abstract: Uterine fibroids are common reproductive-age benign tumors that contribute to severe morbidity and infertility. Cumulative incidence is 4 times higher in Africian-Americans compared to Caucasians and constitutes a major health disparity challenge. Fibroids are the leading indication for hysterectomy and their management averages $21 billion annually in the US. No long term minimally invasive therapies exist. Thus, promising drug therapies, their chemistry, pharmacology, and clinical efficacy, focusing first on innovative drug delivery approaches, are reviewed.
authors.affiliation: Department of Chemistry, North Carolina Central University, 3105 M. Townes Science Building, 1801 Concord Street, Durham, NC 27707, United States ; Departments of Obstetrics and Gynecology and Pathology, Duke University School of Medicine, 242 Sands Building, Box 103206, Durham, NC 27710, United States.
authors.forename: Darlene K
authors.initials: DK
authors.lastname: Taylor
authors.forename: Phyllis C
authors.initials: PC
authors.lastname: Leppert