title: Infant pertussis and household transmission in Korea.
abstract: A recent resurgence of pertussis has raised public health concerns even in developed countries with high vaccination coverage. The aim of this study was to describe the clinical characteristics of infant pertussis, and to determine the relative importance of household transmission in Korea. The multicenter study was prospectively conducted from January 2009 to September 2011. We identified the demographic and clinical data from these patients and performed the diagnostic tests for pertussis in their household contacts. Twenty-one patients with confirmed pertussis were included in the analysis. All infections occurred in infants younger than 6 months of age (mean age, 2.5 months) who had not completed the primary DTaP vaccination except for one patient. Infants without immunization history had a significant higher lymphocytosis and longer duration of hospital stay compared to those with immunization. All were diagnosed with PCR (100%), however, culture tests showed the lowest sensitivity (42.9%). Presumed source of infection in household contacts was documented in 85.7%, mainly parents (52.6%). Pertussis had a major morbidity in young infants who were not fully immunized. Household members were responsible for pertussis transmission of infants in whom a source could be identified. The control of pertussis through booster vaccination with Tdap in family who is taking care of young infants is necessary in Korea.
authors.affiliation: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Sook Kyung
authors.initials: SK
authors.lastname: Yum
authors.forename: Ui Yoon
authors.initials: UY
authors.lastname: Choi
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Jin Han
authors.initials: JH
authors.lastname: Kang
mesh_terms: D001886:Bordetella pertussis / Q000235:genetics; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000276:immunology; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007223:Infant; D007902:Length of Stay; D008218:Lymphocytosis / Q000209:etiology; D008297:Male; D010290:Parents; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D056910:Republic of Korea; D014917:Whooping Cough / Q000175:diagnosis / Q000276:immunology / Q000635:transmission*
chemical_list: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines