title: A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
abstract: OBJECTIVE
  Crohn's disease is an inflammatory bowel disease induced by multiple genetic and environmental factors. Genome-wide association studies have identified genetic factors that affect the risk for Crohn's disease in European populations, but information from other ethnic groups is scarce. We therefore investigated genetic factors associated with Crohn's disease in the Japanese population.
  
  
  METHODS
  We performed a genome-wide association study with 372 individuals with Crohn's disease (cases) and 3389 controls, all from the Japanese population. To confirm identified associations, we performed a replication study with an independent panel of 1151 Crohn's disease cases and 15,800 controls. We also performed an association analysis using genome-wide genotype imputation in the discovery cohort.
  
  
  RESULTS
  We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10(-59)), TNFSF15 (rs6478106, P = 3.87 × 10(-45)), and STAT3 (rs9891119, P = 2.24 × 10(-14)). We identified 2 new susceptibility loci: on chromosome 4p14 (rs1487630, P = 2.40 × 10(-11); odds ratio, 1.33), and in the SLC25A15-ELF1-WBP4 region on 13q14 (rs7329174 in ELF1, P = 5.12 × 10(-9); odds ratio, 1.27).
  
  
  CONCLUSIONS
  In a genome-wide association study, we identified 2 new susceptibility loci for Crohn's disease in a Japanese population. These findings could increase our understanding of the pathogenesis of Crohn's disease.
authors.affiliation: Laboratory for Genotyping Development, Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Junji
authors.initials: J
authors.lastname: Umeno
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirano
authors.forename: Todd Andrew
authors.initials: TA
authors.lastname: Johnson
authors.forename: Natsuhiko
authors.initials: N
authors.lastname: Kumasaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Morizono
authors.forename: Naoya
authors.initials: N
authors.lastname: Hosono
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Takazoe
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Yamada
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Motoya
authors.forename: Masayo
authors.initials: M
authors.lastname: Hosokawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Arimura
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Shinomura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Matsui
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iida
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Tsunoda
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003424:Crohn Disease / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D055106:Genome-Wide Association Study / Q000379:methods*; D005838:Genotype; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D017678:Sex Distribution