title: Comparison of the cross-antibody response induced in sheep by inactivated bovine viral diarrhoea virus 1 and Hobi-like pestivirus.
abstract: Hobi-like pestivirus, a new tentative species within genus Pestivirus, was firstly detected in foetal bovine serum batches and later associated to respiratory distress and reproductive failures in cattle. In the present study, the cross-antibody response between bovine viral diarrhoea virus 1 (BVDV-1) and the emerging pestivirus was evaluated in the sheep model. Ten sheep were immunised against BVDV-1 or Hobi-like pestivirus using inactivated preparations and the induced antibody responses were evaluated against the homologous and heterologous viruses. The results showed that heterologous antibody titres were significantly lower than the homologous ones, thus suggesting the need to develop specific vaccines against the emerging pestiviral species.
authors.affiliation: Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy. nicola.decaro@uniba.it
authors.forename: Nicola
authors.initials: N
authors.lastname: Decaro
authors.forename: Viviana
authors.initials: V
authors.lastname: Mari
authors.forename: Rossana
authors.initials: R
authors.lastname: Sciarretta
authors.forename: Maria Stella
authors.initials: MS
authors.lastname: Lucente
authors.forename: Michele
authors.initials: M
authors.lastname: Camero
authors.forename: Michele
authors.initials: M
authors.lastname: Losurdo
authors.forename: Vittorio
authors.initials: V
authors.lastname: Larocca
authors.forename: Valeriana
authors.initials: V
authors.lastname: Colao
authors.forename: Nicola
authors.initials: N
authors.lastname: Cavaliere
authors.forename: Angela
authors.initials: A
authors.lastname: Lovero
authors.forename: Eleonora
authors.initials: E
authors.lastname: Lorusso
authors.forename: Canio
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D030241:Diarrhea Virus 1, Bovine Viral / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D009500:Neutralization Tests / Q000662:veterinary; D010576:Pestivirus / Q000276:immunology*; D018182:Pestivirus Infections / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D012756:Sheep / Q000276:immunology / Q000821:virology; D012757:Sheep Diseases / Q000276:immunology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral