title: [Expression of A-kinase anchor protein 95, cyclin E2, and connexin 43 in lung cancer tissue, clinical significance of their expression, and their expression correlation].
abstract: OBJECTIVE
  To study the expression of A-kinase anchor protein 95 (AKAP95), cyclin E(2), and connexin 43 (Cx43) in lung cancer tissue, the clinical significance of their expression, and the expression correlation among the three proteins.
  
  
  METHODS
  Fifty-one samples of lung cancer tissue were examined by immunohistochemistry to measure the expression of AKAP95, cyclin E2, and Cx43.
  
  
  RESULTS
  The positive rate of AKAP95 expression in lung cancer tissue was significantly higher than that in paracancerous tissue (82.35% vs 33.33%, P < 0.05); AKAP95 expression was associated with the cell differentiation and histopathological type of lung cancer (P < 0.05). The positive rate of cyclin E(2) expression in lung cancer tissue was significantly higher than that in paracancerous tissue (43.14% vs 13.33%, P < 0.05); cyclin E(2) expression was associated with the lymph node metastasis and histopathological type of lung cancer (P < 0.05). The positive rate of Cx43 expression in lung cancer tissue was lower than that in paracancerous tissue (60.78% vs 80.00%); Cx43 expression was associated with the cell differentiation, lymph node metastasis, and histopathological type of lung cancer (P < 0.05). There was correlation between each two of AKAP95 expression, cyclin E(2) expression, and Cx43 expression in lung cancer tissue.
  
  
  CONCLUSIONS
  High expression of AKAP95 and cyclin E(2) plays an important role in the occurrence and development of lung cancer. AKAP95 expression is associated with the cell differentiation and histopathological type of lung cancer, and cyclin E2 expression is associated with lymph node metastasis and histopathological type. There is correlation between each two of AKAP95 expression, cyclin E(2) expression, and Cx43 expression in lung cancer tissue.
authors.affiliation: Department of Medical Oncology, The Second Hospital of Xiamen Affiliated to Fujian Medical University, Xiamen 361036, China.
authors.forename: Yi-de
authors.initials: YD
authors.lastname: Chen
authors.forename: Xiao-xuan
authors.initials: XX
authors.lastname: Chen
authors.forename: Li-na
authors.initials: LN
authors.lastname: Shen
authors.forename: Feng-chao
authors.initials: FC
authors.lastname: Liang
authors.forename: Ye
authors.initials: Y
authors.lastname: Ding
authors.forename: Xiu-yi
authors.initials: XY
authors.lastname: Yu
authors.forename: Mao-qiang
authors.initials: MQ
authors.lastname: Xue
authors.forename: Yong-xing
authors.initials: YX
authors.lastname: Zhang
mesh_terms: D054758:A Kinase Anchor Proteins / Q000378:metabolism*; D000328:Adult; D000368:Aged; D018031:Connexin 43 / Q000378:metabolism*; D016213:Cyclins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged
chemical_list: D054758:A Kinase Anchor Proteins; C485099:AKAP8 protein, human; C503688:CCNE2 protein, human; D018031:Connexin 43; D016213:Cyclins