title: Toward a three-dimensional view of protein networks between species.
abstract: General principles governing biomolecular interactions between species are expected to differ significantly from known principles governing the interactions within species, yet these principles remain poorly understood at the systems level. A key reason for this knowledge gap is the lack of a detailed three-dimensional (3D), atomistic view of biomolecular interaction networks between species. Recent progress in structural biology, systems biology, and computational biology has enabled accurate and large-scale construction of 3D structural models of nodes and edges for protein-protein interaction networks within and between species. The resulting within- and between-species structural interaction networks have provided new biophysical, functional, and evolutionary insights into species interactions and infectious disease. Here, we review the nascent field of between-species structural systems biology, focusing on interactions between host and pathogens such as viruses.
authors.affiliation: Bioinformatics Program, Boston University Boston, MA, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Franzosa
authors.forename: Sara
authors.initials: S
authors.lastname: Garamszegi
authors.forename: Yu
authors.initials: Y
authors.lastname: Xia