title: Long-term red blood cell exchange in children with sickle cell disease: manual or automatic?
abstract: Little information is available on erythrocytapheresis in children with sickle cell disease, and no comparison has ever been made with manual exchanges in a long-term blood exchange program. We matched a historical cohort of five patients who received 60 erythrocytapheresis procedures with five who received 124 manual exchanges. Long-term erythrocytapheresis was feasible and well-tolerated even in children of low weight. In a long-term approach, automated exchanges were more efficient in maintaining a low HbS level, and exchanges could be spaced out. This approach appears especially useful in the cases where the HbS level must be maintained below 30%.
authors.affiliation: CHU Bordeaux Hôpital Haut-Lévêque, Service hématologie, Pessac, France. cedric.duclos@chu-bordeaux.fr
authors.forename: C
authors.initials: C
authors.lastname: Duclos
authors.forename: E
authors.initials: E
authors.lastname: Merlin
authors.forename: C
authors.initials: C
authors.lastname: Paillard
authors.forename: I
authors.initials: I
authors.lastname: Thuret
authors.forename: F
authors.initials: F
authors.lastname: Demeocq
authors.forename: G
authors.initials: G
authors.lastname: Michel
authors.forename: J
authors.initials: J
authors.lastname: Kanold
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D017707:Erythrocyte Transfusion; D005260:Female; D006451:Hemoglobin, Sickle / Q000378:metabolism; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D006451:Hemoglobin, Sickle