title: Renal impairment in children with posterior urethral valves.
abstract: BACKGROUND
  Posterior urethral valves (PUV) are a common cause of end-stage renal failure in childhood. Our aim was to describe a cohort of patients with PUV and to investigate the predictors of renal impairment.
  
  
  METHODS
  We performed a retrospective chart review of children with PUV who were followed at King Abdulaziz University hospital between 2002 and 2011.
  
  
  RESULTS
  The cohort comprised 68 boys. There was a significant difference in the duration of follow-up (p = 0.024), nadir serum creatinine (p < 0.001), and last known serum creatinine level (p = 0.001) between the patients with and without renal impairment. The duration of follow-up appeared to be a significant predictor for serum creatinine doubling (p = 0.003; odds ratio, 1.8). There was no difference in the age of presentation, age at the time of the study, and first or last serum creatinine between children who initially had vesicostomy and children who had ablation.
  
  
  CONCLUSIONS
  Ablation of PUV or vesicostomy did not influence kidney function in our study cohort. Children with a normal nadir serum creatinine who presented early had a better outcome.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia. jkari@doctors.org.uk
authors.forename: Jameela Abdulaziz
authors.initials: JA
authors.lastname: Kari
authors.forename: Sherif
authors.initials: S
authors.lastname: El-Desoky
authors.forename: Youssef M K
authors.initials: YM
authors.lastname: Farag
authors.forename: Youssef
authors.initials: Y
authors.lastname: Farag
authors.forename: Hisham
authors.initials: H
authors.lastname: Mosli
authors.forename: Abdul-Malik
authors.initials: AM
authors.lastname: Altyieb
authors.forename: Ahmad
authors.initials: A
authors.lastname: Al Sayad
authors.forename: Othman
authors.initials: O
authors.lastname: Radawi
authors.forename: Hosam
authors.initials: H
authors.lastname: Ghabra
authors.forename: Faten
authors.initials: F
authors.lastname: Basnawi
authors.forename: Ohood
authors.initials: O
authors.lastname: Bahrawi
authors.forename: Ajay
authors.initials: A
authors.lastname: Singh
authors.forename: Hassan
authors.initials: H
authors.lastname: Farsi
mesh_terms: D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D003559:Cystostomy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D051437:Renal Insufficiency / Q000209:etiology*; D012189:Retrospective Studies; D014521:Urethra / Q000002:abnormalities*
chemical_list: D003404:Creatinine