title: An organocatalytic asymmetric double Michael cascade reaction of unsaturated ketones and unsaturated pyrazolones: highly efficient synthesis of spiropyrazolone derivatives.
abstract: The first organocatalytic double Michael cascade reaction between unsaturated ketones and unsaturated pyrazolones has been developed which provides spiropyrazolone core structures containing two interval or three consecutive stereogenic centers with excellent diastereo- (>20:1) and enantioselectivities (up to 99% ee). Moreover, a pair of enantiomers and can be achieved via different catalysts.
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Life Sciences, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
authors.forename: Jinyan
authors.initials: J
authors.lastname: Liang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Chen
authors.forename: Luping
authors.initials: L
authors.lastname: Liu
authors.forename: Xianxing
authors.initials: X
authors.lastname: Jiang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D047069:Pyrazolones / Q000138:chemical synthesis* / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D007659:Ketones; D047069:Pyrazolones; D013141:Spiro Compounds