title: Baseline E(2) levels are higher in BRCA2 mutation carriers: a potential target for prevention?
abstract: OBJECTIVE
  BRCA gene mutations and elevated serum estradiol (E(2)) are well-known risk factors for breast cancer. The aim of this study was to investigate the association between BRCA gene mutations and serum E(2) level.
  
  
  METHODS
  We measured baseline (menstrual cycle day 2-3) E(2) levels of 96 women with breast cancer who underwent BRCA testing.
  
  
  RESULTS
  The mean age, parity, and age at menarche did not differ between women with and without BRCA1/2 mutations. Basal serum E(2) level was significantly higher in women with BRCA2 mutations compared to women with BRCA1 mutations or without BRCA mutations (71.7 ± 41.6 vs. 45.5 ± 20.7 vs. 38.5 ± 12.6 pg/ml in BRCA2 mutation carriers, BRCA1 mutation carriers, and non-carriers, respectively, p value = 0.03). Women with BRCA2 mutations had 3.1 times as great risk for high basal E(2) level (>48 pg/ml) as women without BRCA mutations after adjusting for age and BMI (95 % confidence interval: 1.3, 7.6). BRCA mutation carriers with high serum E(2) level were significantly younger than the carriers with low serum E(2) level (31.4 ± 3.1 vs. 34.7 ± 4.9 years, p = 0.04).
  
  
  CONCLUSIONS
  In this pilot study, we found an association between high basal serum E(2) levels and BRCA2 mutations. Our results suggest that increased production of E(2) may have a role in the pathogenesis of BRCA2-mutation-related breast cancer.
authors.affiliation: Department of Obstetrics & Gynecology, New York Medical College and Institute for Fertility Preservation, Rye, NY, USA.
authors.forename: Jayeon
authors.initials: J
authors.lastname: Kim
authors.forename: Kutluk
authors.initials: K
authors.lastname: Oktay
mesh_terms: D000328:Adult; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000097:blood* / Q000235:genetics* / Q000517:prevention & control; D004958:Estradiol / Q000097:blood* / Q000378:metabolism; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood; D010865:Pilot Projects; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D024682:BRCA2 Protein; D004958:Estradiol