title: Melanoma and other malignant skin cancers in psoriatic patients treated with phototherapy. Role of the p16 protein in psoriasis.
abstract: Recently, the potential risk of malignant cancer development in psoriatic patients has been highlighted. However, the relationship between the therapeutic schemes in psoriasis and possible neoplastic transformation has not been so far clearly explained. Phototherapy is considered a very effective therapeutic method in psoriasis, however, the pathogenesis of some malignancies may be associated with the exposure to UV radiation. p16 protein belongs to the defense mechanisms that protect cells from damage and mutagenic factors, such as UV radiation. In recent years, the altered expression of the p16 protein in the diseases not related to malignant transformation, including psoriasis, has been observed. These new observations suggest participation of the p16 protein in the mechanisms of psoriatic plaque formation.
authors.affiliation: Non-Public Health Care Centre Med-Laser, Lublin, Poland. anna.szponar@wp.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Szponar-Bojda
authors.forename: Aldona
authors.initials: A
authors.lastname: Pietrzak
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Sobczynska-Tomaszewska
authors.forename: Adam
authors.initials: A
authors.lastname: Borzecki
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kurylcio
authors.forename: Wojciech
authors.initials: W
authors.lastname: Polkowski
authors.forename: Anna
authors.initials: A
authors.lastname: Poluha
authors.forename: Grazyna
authors.initials: G
authors.lastname: Chodorowska
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000473:pathology; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D006801:Humans; D008545:Melanoma / Q000209:etiology* / Q000473:pathology; D011701:PUVA Therapy / Q000009:adverse effects*; D011565:Psoriasis / Q000150:complications* / Q000378:metabolism / Q000628:therapy*; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16