title: The chromosome-centric human proteome project: a call to action.
abstract: The grand vision of the human proteome project (HPP) is moving closer to reality with the recent announcement by HUPO of the creation of the HPP consortium in charge of the development of a two-part HPP, one focused on the description of proteomes of biological samples or related to diseases (B/D-HPP) and the other dedicated to a systematic description of proteins as gene products encoded in the human genome (the C-HPP). This new initiative of HUPO seeks to identify and characterize at least one representative protein from every gene, create a protein distribution atlas and a protein pathway or network map. This vision for proteomics can be the roadmap of biological and clinical research for years to come if it delivers on its promises. The Industrial Advisory Board (IAB) to HUPO shares the visions of C-HPP. The IAB will support and critically accompany the overall project goals and the definitions of the critical milestones. The member companies are in a unique position to develop hardware and software, reagents and standards, procedures, and workflows to ensure a reliable source of tools available to the proteomics community worldwide. In collaboration with academia, the IAB member companies can and must develop the tools to reach the ambitious project goals. We offer to partner with and challenge the academic groups leading the C-HPP to define both ambitious and obtainable goals and milestones to make the C-HPP a real and trusted resource for future biology.
authors.affiliation: Thermo Fisher Scientific, Life Science Mass Spectrometry, San Jose, California 95134, United States.
authors.forename: Andreas F R
authors.initials: AF
authors.lastname: Hühmer
authors.forename: Aran
authors.initials: A
authors.lastname: Paulus
authors.forename: LeRoy B
authors.initials: LB
authors.lastname: Martin
authors.forename: Kevin
authors.initials: K
authors.lastname: Millis
authors.forename: Tasha
authors.initials: T
authors.lastname: Agreste
authors.forename: Julian
authors.initials: J
authors.lastname: Saba
authors.forename: Jennie R
authors.initials: JR
authors.lastname: Lill
authors.forename: Steven M
authors.initials: SM
authors.lastname: Fischer
authors.forename: William
authors.initials: W
authors.lastname: Dracup
authors.forename: Paddy
authors.initials: P
authors.lastname: Lavery
mesh_terms: D002877:Chromosomes, Human / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D015894:Genome, Human; D016045:Human Genome Project; D006801:Humans; D011506:Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism; D040901:Proteomics
chemical_list: D011506:Proteins