title: Compounds from the roots and rhizomes of Valeriana amurensis protect against neurotoxicity in PC12 cells.
abstract: Three new germacrane-type sesquiterpenoids, heishuixiecaoline A-C (compounds 1-3), were isolated along with ten known compounds 4-13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer's disease (AD). The structures of 1-3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1-13 on the neurotoxicity of  PC12 cells induced by amyloid-beta (Aβ(25-25)), respectively. As a result, germacrane-type sesquiterpenoids 1-4 and lignans 5-7 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.
authors.affiliation: Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, No. 24 HePing Road, XiangFang District, Harbin 150040, China. qhwang668@sina.com
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Wang
authors.forename: Changfu
authors.initials: C
authors.lastname: Wang
authors.forename: Yueming
authors.initials: Y
authors.lastname: Zuo
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Wang
authors.forename: Bingyou
authors.initials: B
authors.lastname: Yang
authors.forename: Haixue
authors.initials: H
authors.lastname: Kuang
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000633:toxicity; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016716:PC12 Cells; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D027343:Rhizome / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014632:Valerian / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D017705:Lignans; D018696:Neuroprotective Agents; D012717:Sesquiterpenes