title: Common sequence variants in CD36 gene and the levels of triglyceride and high-density lipoprotein cholesterol among ethnic Chinese in Taiwan.
abstract: BACKGROUND
  Evidence of the genetic association between CD36 candidate gene and the risk of metabolic syndrome and its components has been inconsistent. This case-control study assessed the haplotype-tagged SNPs from CD36 on the risk of metabolic syndrome and components.
  
  
  RESULTS
  We recruited 1,000 cases and age, gender-matched controls were randomly selected from the participants with metabolic syndrome defined by International Diabetes Federation. Overall, the haplotype tagged SNPs of CD36 gene were not related to the risk of metabolic syndrome. For individuals with normal lipid levels, several SNPs were significantly associated with the triglycerides and HDL-cholesterol levels: Subjects with rs3211848 homozygote had a higher triglyceride level (99.16 ± 2.61 mg/dL), compared with non-carriers (89.27 ± 1.45 mg/dL, P = 0.001). In addition, compared with non-carriers, individuals with rs1054516 heterozygous and homozygous genotypes had a significantly lower HDL-cholesterol (46.6 ± 0.46 mg/dL for non-carrier, 44.6 ± 0.36 mg/dL for heterozygous, and 44.3 ± 0.56 mg/dL for homozygous, P = 0.0008).
  
  
  CONCLUSIONS
  The CD36 gene variants were significantly associated with triglycerides and HDL-cholesterol concentrations among ethnic Chinese in Taiwan.
authors.affiliation: Institute of Epidemiology & Preventive Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Kuo-Liong
authors.initials: KL
authors.lastname: Chien
authors.forename: Hsiu-Ching
authors.initials: HC
authors.lastname: Hsu
authors.forename: Pi-Hua
authors.initials: PH
authors.lastname: Liu
authors.forename: Hung-Ju
authors.initials: HJ
authors.lastname: Lin
authors.forename: Ming-Fong
authors.initials: MF
authors.lastname: Chen
mesh_terms: D044466:Asian People / Q000235:genetics; D018955:CD36 Antigens / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D056726:Genetic Association Studies; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan; D014280:Triglycerides / Q000097:blood / Q000235:genetics
chemical_list: D018955:CD36 Antigens; D008076:Cholesterol, HDL; D014280:Triglycerides