title: Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones.
abstract: An organocatalytic enantioselective addition reaction of cyclic ketoimines with phosphites has been developed for the first time. The process, catalyzed by Soós' quinine thiourea, affords synthetically and medicinally interesting enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities.
authors.affiliation: Department of Chemistry and Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA.
authors.forename: Hexin
authors.initials: H
authors.lastname: Xie
authors.forename: Aiguo
authors.initials: A
authors.lastname: Song
authors.forename: Xinshuai
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaobei
authors.initials: X
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Chunquan
authors.initials: C
authors.lastname: Sheng
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D054879:Halogenation; D008958:Models, Molecular; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry; D011803:Quinine / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D052999:Quinazolinones; D011803:Quinine; D013890:Thiourea