title: Non-benzimidazole containing inhibitors of respiratory syncytial virus.
abstract: Several non-benzimidazole containing inhibitors of respiratory syncytial virus are described. Core template modification, analysis of antiviral activity, physicochemistry and optimisation of properties led to the thiazole-imidazole 13, that showed a good potency and pharmacokinetic profile in the rat.
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer Global R and D, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. David.Pryde@pfizer.com
authors.forename: David C
authors.initials: DC
authors.lastname: Pryde
authors.forename: Thien-Duc
authors.initials: TD
authors.lastname: Tran
authors.forename: Iain
authors.initials: I
authors.lastname: Gardner
authors.forename: Helen
authors.initials: H
authors.lastname: Bright
authors.forename: Paul
authors.initials: P
authors.lastname: Stupple
authors.forename: Sebastien
authors.initials: S
authors.lastname: Galan
authors.forename: Liam
authors.initials: L
authors.lastname: Alsop
authors.forename: Lesa
authors.initials: L
authors.lastname: Watson
authors.forename: Donald S
authors.initials: DS
authors.lastname: Middleton
authors.forename: Satish
authors.initials: S
authors.lastname: Dayal
authors.forename: Michelle
authors.initials: M
authors.lastname: Platts
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Murray
authors.forename: Tanya
authors.initials: T
authors.lastname: Parkinson
authors.forename: Robert
authors.initials: R
authors.lastname: Webster
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D051381:Rats; D012136:Respiratory Syncytial Viruses / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles; D007093:Imidazoles; D013844:Thiazoles; C029899:imidazole; C031000:benzimidazole