title: Calculation of intravascular signal in dynamic contrast enhanced-MRI using adaptive complex independent component analysis.
abstract: Assessing tumor response to therapy is a crucial step in personalized treatments. Pharmacokinetic (PK) modeling provides quantitative information about tumor perfusion and vascular permeability that are associated with prognostic factors. A fundamental step in most PK analyses is calculating the signal that is generated in the tumor vasculature. This signal is usually inseparable from the extravascular extracellular signal. It was shown previously using in vivo and phantom experiments that independent component analysis (ICA) is capable of calculating the intravascular time-intensity curve in dynamic contrast enhanced (DCE)-MRI. A novel adaptive complex independent component analysis (AC-ICA) technique is developed in this study to calculate the intravascular time-intensity curve and separate this signal from the DCE-MR images of tumors. The use of the complex-valued DCE-MRI images rather than the commonly used magnitude images satisfied the fundamental assumption of ICA, i.e., linear mixing of the sources. Using an adaptive cost function in ICA through estimating the probability distribution of the tumor vasculature at each iteration resulted in a more robust and accurate separation algorithm. The AC-ICA algorithm provided a better estimate for the intravascular time-intensity curve than the previous ICA-based method. A simulation study was also developed in this study to realistically simulate DCE-MRI data of a leaky tissue mimicking phantom. The passage of the MR contrast agent through the leaky phantom was modeled with finite element analysis using a diffusion model. Once the distribution of the contrast agent in the imaging field of view was calculated, DCE-MRI data was generated by solving the Bloch equation for each voxel at each time point. The intravascular time-intensity curve calculation results were compared to the previously proposed ICA-based intravascular time-intensity curve calculation method that applied ICA to the magnitude of the DCE-MRI data (Mag-ICA) using both simulated and experimental tissue mimicking phantoms. The AC-ICA demonstrated superior performance compared to the Mag-ICA method. AC-ICA provided more accurate estimate of intravascular time-intensity curve, having smaller error between the calculated and actual intravascular time-intensity curves compared to the Mag-ICA. Furthermore, it showed higher robustness in dealing with datasets with different resolution by providing smaller variation between the results of each datasets and having smaller difference between the intravascular time-intensity curves of various resolutions. Thus, AC-ICA has the potential to be used as the intravascular time-intensity curve calculation method in PK analysis and could lead to more accurate PK analysis for tumors.
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9 Canada. hatef.mehrabian@sri.utoronto.ca
authors.forename: Hatef
authors.initials: H
authors.lastname: Mehrabian
authors.forename: Rajiv
authors.initials: R
authors.lastname: Chopra
authors.forename: Anne L
authors.initials: AL
authors.lastname: Martel
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003287:Contrast Media / Q000493:pharmacokinetics*; D016208:Databases, Factual; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D008954:Models, Biological; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted; D013223:Statistics as Topic
chemical_list: D003287:Contrast Media