title: Anti-adhesion methods as novel therapeutics for bacterial infections.
abstract: Anti-adhesion therapies for bacterial infections offer an alternative to antibiotics, with those therapies bacteria are not killed but are prevented from causing harm to a host by inhibiting adherence to host cells and tissues, a prerequisite for the majority of infectious diseases. The mechanisms of these potential therapeutic agents include inhibition of adhesins and their host receptors, vaccination with adhesins or analogs, use of probiotics and dietary supplements that interfere with receptor-adhesin interactions, subminimal inhibitory concentrations of antibiotics and manipulation of hydrophobic interactions. Once developed, these drugs will contribute to the arsenal for fighting infectious disease in the future, potentially subverting antibiotic resistance.
authors.affiliation: Department of Infection & Immunity, K Floor, Royal Hallamshire Hospital, Sheffield School of Medicine & Biomedical Science, University of Sheffield, Sheffield, S10 3JF, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Cozens
authors.forename: Robert C
authors.initials: RC
authors.lastname: Read
mesh_terms: D018829:Adhesins, Bacterial / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001422:Bacterial Adhesion / Q000187:drug effects* / Q000276:immunology; D001424:Bacterial Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D006801:Humans; D009844:Oligosaccharides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D018829:Adhesins, Bacterial; D000900:Anti-Bacterial Agents; D001428:Bacterial Vaccines; D009844:Oligosaccharides