title: Expanded protein expression profile of human placenta using two-dimensional gel electrophoresis.
abstract: Studying proteins expressed in placenta is important to understand its function in pregnancy and fetal growth. Here, we present protein expression profiling from normal human placenta by 2-D gel - MS/MS approach that resulted in identification of 117 unique proteins. Integration with earlier analyses resulted in a profile of 423 non-redundant proteins, 75 of them being new identifications unique to this study including their isoforms. We present a compilation of placental protein expressions identified by proteomic approaches, their functions and known clinical implications. We believe that our dataset would be a useful resource for studies related to placental dysfunction.
authors.affiliation: CSIR - Centre for Cellular and Molecular Biology (CCMB), Uppal Road, Hyderabad 500 007, India.
authors.forename: D
authors.initials: D
authors.lastname: Mushahary
authors.forename: P
authors.initials: P
authors.lastname: Gautam
authors.forename: C S
authors.initials: CS
authors.lastname: Sundaram
authors.forename: R
authors.initials: R
authors.lastname: Sirdeshmukh
mesh_terms: D030562:Databases, Protein; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000302:isolation & purification / Q000378:metabolism*; D040081:Protein Array Analysis / Q000379:methods*; D040901:Proteomics; D053719:Tandem Mass Spectrometry
chemical_list: D011257:Pregnancy Proteins