title: Hsp-27 expression in invasive ductal breast carcinoma.
abstract: The aim of this study was to determine the intensity of Hsp27 protein expression in fibrocystic breast changes (FC) and invasive ductal breast carcinoma (IDC) and to examine its impact on patients' clinico-pathological characteristics and overall survival. Immunohistochemical reactions were conducted on archival samples of 20 cases of FC and 101 cases of IDC treated in 1999-2002. Nuclear-cytoplasmic Hsp27 expression was observed in 92 (92.1%) of the examined cases of IDC, and all the cases of FC. Significantly higher Hsp27 expression was observed in G2 (p < 0.01) and G3 cases (p < 0.0001) compared to FC. HER-2 positive cases had higher Hsp27 expression (p = 0.0153), than HER-2 negative cases. Our research showed that Hsp27 could have an impact on tumor malignancy. Moreover, a positive correlation between the expression of Hsp27 and HER-2 positive cases was demonstrated.
authors.affiliation: Department of Histology and Embryology, Medical University, Wroclaw, Poland.
authors.forename: Jedrzej
authors.initials: J
authors.lastname: Grzegrzolka
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kurnol
authors.forename: Pawel
authors.initials: P
authors.lastname: Piotrow
authors.forename: Bartosz
authors.initials: B
authors.lastname: Pula
authors.forename: Christopher
authors.initials: C
authors.lastname: Kobierzycki
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Piotrowska
authors.forename: Karolina
authors.initials: K
authors.lastname: Jablonska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wojnar
authors.forename: Janusz
authors.initials: J
authors.lastname: Rys
authors.forename: Piotr
authors.initials: P
authors.lastname: Dziegiel
authors.forename: Marzena
authors.initials: M
authors.lastname: Podhorska-Okolow
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins; D006801:Humans; D008875:Middle Aged; D018832:Molecular Chaperones; D009361:Neoplasm Invasiveness; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism
chemical_list: D055551:HSP27 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D018719:Erb-b2 Receptor Tyrosine Kinases; C057725:HSPB1 protein, human