title: The polymorphism -1131T>C in apolipoprotein A5 gene is associated with dyslipidemia in Brazilian subjects.
abstract: BACKGROUND
  Polymorphisms in apolipoprotein A5 gene (APOA5) have been associated with higher triglyceride levels in many populations. The aim of the study was to determine the allelic and genotypic distribution of the APOA5 -1131T>C polymorphism and to identify the association of the genetic variant and the risk for dyslipidemia.
  
  
  METHODS
  We genotyped 109 dyslipidemic subjects and 107 controls. The total cholesterol, triglycerides and HDL-c were determined enzymatically. Comparison of means among groups was calculated by ANOVA. Significant differences among groups were evaluated by Student-Newman-Keuls test.
  
  
  RESULTS
  The minor allele C was more frequent in dyslipidemic subjects than controls (p=0.019) and confers an increased individual risk for dyslipidemia (OR=1.726, CI 95%=1.095-2.721). The genotype analysis by gender showed that this allele was more frequent in dyslipidemic males (p=0.037; OR=2.050, CI 95%=1.042-4.023). When participants were analyzed according to genotypes TT and TC/CC, C-carriers presented higher cholesterol and triglycerides levels than TT homozygous (p=0.046 and 0.049, respectively).
  
  
  CONCLUSIONS
  The allele C confers higher total cholesterol and triglycerides levels in dyslipidemic adults. The APOA5 -1131T>C polymorphism is associated with dyslipidemia in male subjects.
authors.affiliation: Setor de Patologia Clínica, Colégio Técnico, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Cláudia N
authors.initials: CN
authors.lastname: Ferreira
authors.forename: Maria G
authors.initials: MG
authors.lastname: Carvalho
authors.forename: Ana P
authors.initials: AP
authors.lastname: Fernandes
authors.forename: Izabela R
authors.initials: IR
authors.lastname: Santos
authors.forename: Kathryna F
authors.initials: KF
authors.lastname: Rodrigues
authors.forename: Angela M Q
authors.initials: AM
authors.lastname: Lana
authors.forename: Cristina R
authors.initials: CR
authors.lastname: Almeida
authors.forename: Andréia A
authors.initials: AA
authors.lastname: Loures-Vale
authors.forename: Karina B
authors.initials: KB
authors.lastname: Gomes
authors.forename: Marinez O
authors.initials: MO
authors.lastname: Sousa
mesh_terms: D000328:Adult; D000483:Alleles; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000235:genetics* / Q000378:metabolism; D001938:Brazil; D002318:Cardiovascular Diseases / Q000235:genetics; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D014280:Triglycerides; D002784:Cholesterol