title: [Analysis of prognostic factors in patients with lymph node-negative rectal cancer].
abstract: OBJECTIVE
  To investigate the risk factors for the prognosis in patients with node-negative rectal cancer.
  
  
  METHODS
  Clinicopathological  characteristics of 117 patients with lymph node-negative rectal carcinoma undergoing curative rectectomy from January 2005 to December 2008 were  retrospectively analyzed.
  
  
  RESULTS
  The overall 5-year survival rate was 91.5%. The univariate analysis revealed that tumor size(χ(2)=8.422,P=0.004),  invasive depth(T staging, χ(2)=9.448,P=0.024), cell differentiation(χ(2)=26.571,P=0.000), pathologic type(χ(2)=4.712,P=0.030) and preoperative level of  carcinoembryonic antigen(χ(2)=4.131,P=0.042) had significant effects on the survival. In multivariate analysis, the independent prognostic factors for these  patients were tumor size (Wald=5.286,P=0.022), cell differentiation (Wald=7.172, P=0.007) and invasive depth (T staging, Wald=5.741, P=0.017).
  
  
  CONCLUSIONS
  For node-negative rectal cancer patients, tumor size, poor differentiation and invasive depth are important markers to evaluate their  prognosis.
authors.affiliation: Department of General Surgery, Peking University First Hospital, Beijing, China.
authors.forename: Ying-chao
authors.initials: YC
authors.lastname: Wu
authors.forename: Shen
authors.initials: S
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Yu-cun
authors.initials: YC
authors.lastname: Liu
authors.forename: Yuan-lian
authors.initials: YL
authors.lastname: Wan
authors.forename: Shan-jun
authors.initials: SJ
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology*; D012189:Retrospective Studies; D015996:Survival Rate