title: Omics Screening for Pharmaceutical Efficacy and Safety in Clinical Practice.
abstract: As molecular techniques have improved, investigators have attempted to improve pharmaceutical efficacy and safety by making trait associations with genomic, epigenomic, transcriptomic, proteomic, and metabolomic polymorphisms. The 'omics era has seen screening assays for pharmaceutical efficacy and safety translated into clinical practice. This manuscript will discuss each 'omic field and the screening assays available to the clinician. While success has been demonstrated in each 'omic field, many challenges remain. Assays need wider availability, predictive values remain low, and costs remain high. In order for clinicians to realize improved efficacy and safety due 'omic screens, development of improved techniques, combining of 'omic assays, and increased clinical utilization is necessary. This is an exciting time for investigators and clinicians that desire improved pharmaceutical therapy.
authors.affiliation: Rocky Mountain Poison and Drug Center, Denver, CO, USA ; University of Colorado School of Medicine, Department of Emergency Medicine Aurora, CO, USA.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Monte
authors.forename: Vasilis
authors.initials: V
authors.lastname: Vasiliou
authors.forename: Kennon J
authors.initials: KJ
authors.lastname: Heard