title: T cell-based gene therapy of cancer.
abstract: Adoptive immunotherapy using gene engineered T cells is a promising and rapidly evolving field, and the ability to engineer T cells to manifest desired phenotypes and functions has become a practical reality. In this review, we describe and summarize current thought about gene engineering of T cells. We focus on the identified requirements for the successful application of T cell based immunotherapy and discuss gene-therapy based strategies that address these requirements and have the potential to enhance the successful implementation of this promising approach to treat cancer.
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa., USA.
authors.forename: Saar
authors.initials: S
authors.lastname: Gill
authors.forename: Michael
authors.initials: M
authors.lastname: Kalos
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D015316:Genetic Therapy; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000276:immunology / Q000628:therapy*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D057170:Translational Research, Biomedical
chemical_list: D000951:Antigens, Neoplasm