title: Effectiveness of first-line antiretroviral therapy and acquired drug resistance among HIV-1-infected children in India.
abstract: Analysis of treatment response among HIV-infected children in India on first-line antiretroviral treatment for >2 years revealed that 85% were virologically suppressed. Of those with virologic failure, only 17% manifested immunologic failure, whereas majority had resistance-associated mutations. The presence of resistance highlights the need for virologic monitoring of children receiving antiretroviral treatment to optimize treatment success and preserve future treatment options.
authors.affiliation: Department of Paediatrics, St. John's Medical College and Hospital, Bangalore, India. anitashet@gmail.com
authors.forename: Anita
authors.initials: A
authors.lastname: Shet
authors.forename: Ujjwal
authors.initials: U
authors.lastname: Neogi
authors.forename: Pravat Nalini
authors.initials: PN
authors.lastname: Sahoo
authors.forename: Ayesha
authors.initials: A
authors.lastname: De Costa
mesh_terms: D000293:Adolescent; D044966:Anti-Retroviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D009154:Mutation; D016896:Treatment Outcome; D019562:Viral Load / Q000187:drug effects
chemical_list: D044966:Anti-Retroviral Agents