title: Quantification of dynamic contrast-enhanced ultrasound in HCC: prediction of response to a new combination therapy of sorafenib and panobinostat in advanced hepatocellular carcinoma.
abstract: Here, we report the case of a patient, who showed an antitumour response to a new combination therapy of sorafenib and the histon deacetylase inhibitor panobinostat (LBH-589). D-CEUS (Dynamic contrast-enhanced ultrasonography) was able to predict response to the new therapy regime and may be an interesting tool in the early evaluation of response to therapy. It might be especially useful to differentiate between responders and non-responders of new-targeted pharmaceuticals like multikinase inhibitors in hepatocellular carcinomas.
authors.affiliation: Department of Medicine 1, University of Erlangen, Erlangen, Germany.
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Knieling
authors.forename: Maximilian J
authors.initials: MJ
authors.lastname: Waldner
authors.forename: Ruediger S
authors.initials: RS
authors.lastname: Goertz
authors.forename: Deike
authors.initials: D
authors.lastname: Strobel
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D003287:Contrast Media; D017809:Fatal Outcome; D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage; D007211:Indoles / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077767:Panobinostat; D010671:Phenylurea Compounds / Q000008:administration & dosage; D000077157:Sorafenib; D014463:Ultrasonography / Q000379:methods
chemical_list: D003287:Contrast Media; D006877:Hydroxamic Acids; D007211:Indoles; D010671:Phenylurea Compounds; D009536:Niacinamide; D000077767:Panobinostat; D000077157:Sorafenib