title: [Frequency and linkage disequilibrium of specific HLA-DR and HLA-DQ genes in Chinese Han population].
abstract: This study was aimed to investigate the distribution feature of HLA-DR/DQ gene linkage disequilibrium in Chinese Han population and to improve the accuracy of HLA matching results. Genotyping of HLA-DR and HLA-DQ gene locus was performed using PCR-SSP typing in Chinese Han population receiving kidney transplantation. The results showed that there were 29 new linkage combinations in 1799 patients, in which DR13-DQ5, DR11-DQ8 and DR8-DQ8 were discovered for 11, 8 and 7 times respectively while DR9-DQ8, DR12-DQ6 and DR14-DQ4 were both discovered for 6 times. The linkage disequilibrium parameters of these haplotypes were negative, showing that these linkages were uncommon. It is concluded that this study not only enriches the classical HLA-DR/DQ linkage combinations, but also indicates the national relevance of combination distribution, and it has great importance in improving the accuracy of HLA matching experiments and reducing unnecessary repeated work.
authors.affiliation: Department of Urology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Su-Xia
authors.initials: SX
authors.lastname: Yang
authors.forename: Zhi-Fei
authors.initials: ZF
authors.lastname: Hu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zu
authors.forename: Jin-Shan
authors.initials: JS
authors.lastname: Lu
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Dong
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D016030:Kidney Transplantation; D015810:Linkage Disequilibrium
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens