title: Comparative study of the healing process when using Vicryl®, Vicryl Rapid®, Vicryl Plus®, and Monocryl® sutures in the rat dermal tissue.
abstract: BACKGROUND
  Various types of sutures are available in the market with different constitutions. However, there is a lack of research to assess and quantify the behavior of these materials.
  This study comes benchmark wires polyglactin 910 (Vicryl®), irradiated polyglactin 910 (Vicryl Rapid®), polyglactin 910 treated with triclosan (Vicryl Plus®), and poliglecaprone 25 (Monocryl®). For this, we used 40 rats that were divided into two groups, underwent two skin incisions longitudinal 2-cm long. In Group A, simple interrupted sutures using irradiated polyglactin 910 on the right and left side of polyglactin 910, and in group B, polyglactin 910 with triclosan on the right and the left poliglecaprone 25 were made. At 2, 7, 14, and 28 days after surgery, the ten animals were killed per period, and the samples were processed for histomorphologic and histometric analysis.
  
  
  CONCLUSIONS
  The results demonstrated that the wire poliglecaprone 25 showed better biological response, with less inflammatory infiltrates and rapid organization of connective tissue.
authors.affiliation: Department of Pathology and Clinical Propedeutics, School of Dentistry of Araçatuba, São Paulo State University- UNESP, São Paulo, Brazil, ellengaetti@gmail.com.
authors.forename: Ellen Cristina
authors.initials: EC
authors.lastname: Gartti-Jardim
authors.forename: Ariane Paredes
authors.initials: AP
authors.lastname: de Souza
authors.forename: Abrahão Cavalcante Gomes de Souza
authors.initials: AC
authors.lastname: Carvalho
authors.forename: Cassiano Costa Silva
authors.initials: CC
authors.lastname: Pereira
authors.forename: Roberta
authors.initials: R
authors.lastname: Okamoto
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Magro Filho
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D020405:Dermis / Q000473:pathology / Q000601:surgery*; D004146:Dioxanes; D008297:Male; D011091:Polyesters; D011098:Polyglactin 910; D051381:Rats; D013537:Sutures; D014260:Triclosan; D014945:Wound Healing / Q000502:physiology*
chemical_list: D020099:Coated Materials, Biocompatible; D004146:Dioxanes; D011091:Polyesters; D011098:Polyglactin 910; C095495:glycolide E-caprolactone copolymer; D014260:Triclosan