title: Plasmonic photothermal therapy increases the tumor mass penetration of HPMA copolymers.
abstract: Effective drug delivery to tumors requires both transport through the vasculature and tumor interstitium. Previously, it was shown that gold nanorod (GNR) mediated plasmonic photothermal therapy (PPTT) is capable of increasing the overall accumulation of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers in prostate tumors. In the present study, it is demonstrated that PPTT is also capable of increasing the distribution of these conjugates in tumors. Gadolinium labeled HPMA copolymers were administered to mice bearing prostate tumors immediately before treatment of the right tumor with PPTT. The left tumor served as internal, untreated control. Magnetic resonance imaging (MRI) of both tumors showed that PPTT was capable of improving the tumor mass penetration of HPMA copolymers. Thermal enhancement of delivery, roughly 1.5-fold, to both the tumor center and periphery was observed. Confocal microscopy of fluorescently labeled copolymers corroborates these findings in that PPTT is capable of delivering more HPMA copolymers to the tumor's center and periphery. These results further demonstrate that PPTT is a useful tool to improve the delivery of polymer-drug conjugates.
authors.affiliation: Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Gormley
authors.forename: Nate
authors.initials: N
authors.lastname: Larson
authors.forename: Afsheen
authors.initials: A
authors.lastname: Banisadr
authors.forename: Ryan
authors.initials: R
authors.lastname: Robinson
authors.forename: Nick
authors.initials: N
authors.lastname: Frazier
authors.forename: Abhijit
authors.initials: A
authors.lastname: Ray
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Ghandehari
mesh_terms: D000465:Algorithms; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002627:Chemistry, Physical; D016503:Drug Delivery Systems; D005260:Female; D006979:Hyperthermia, Induced / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008689:Methacrylates / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D008856:Microscopy, Fluorescence; D053758:Nanoparticles; D009369:Neoplasms / Q000378:metabolism*; D010316:Particle Size
chemical_list: D000970:Antineoplastic Agents; D008689:Methacrylates; C032802:hydroxypropyl methacrylate