title: Vasopressin eliminates the expression of familiar odor bias in neonatal female mice through V1aR.
abstract: V1aR has a well established role in the neural regulation of adult mammalian social behavior. The role of V1aR in developmentally emerging social behavior is less well understood. We mapped V1aR at post-natal day 8 (P8) and demonstrate developmentally-specific expression in the neocortex and hippocampus. We tested the ability of male and female C57BL/6J mice to show orienting bias to a familiar odor at this age. We demonstrate that females, but not males, show an orienting bias for odors previously paired with the mother, which is eliminated by V1aR signaling.
authors.affiliation: Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. liz.hammock@vanderbilt.edu
authors.forename: Elizabeth A D
authors.initials: EA
authors.lastname: Hammock
authors.forename: Caitlin S
authors.initials: CS
authors.lastname: Law
authors.forename: Pat
authors.initials: P
authors.lastname: Levitt
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002630:Chemotactic Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009812:Odorants; D055696:Olfactory Perception / Q000187:drug effects* / Q000235:genetics; D021641:Recognition, Psychology / Q000187:drug effects*; D012727:Sex Characteristics; D014667:Vasopressins / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D002630:Chemotactic Factors; C485895:V1ra1 protein, mouse; D014667:Vasopressins