title: Cutaneous squamous cell carcinoma developing from recessive dystrophic epidermolysis bullosa: a case report and an immunohistochemical study.
abstract: We describe a 49-year-old Japanese woman with cutaneous squamous cell carcinoma (SCC) developing from recessive dystrophic epidermolysis bullosa (RDEB). Interestingly, immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages and numerous Foxp3(+) regulatory T cells (Tregs) around the tumor. Since the contribution of immunosuppressive factors (e.g. TGFβ) to the carcinogenesis of SCC from RDEB was recently reported, our present findings suggest one of the possible contributions of immunosuppressive cells, such as CD163(+) M2 macrophages and Tregs, to the carcinogenesis of SCC from RDEB.
authors.affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Tsukada
authors.forename: Taku
authors.initials: T
authors.lastname: Fujimura
authors.forename: Sadanori
authors.initials: S
authors.lastname: Furudate
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kambayashi
authors.forename: Yukikazu
authors.initials: Y
authors.lastname: Numata
authors.forename: Takahiro
authors.initials: T
authors.lastname: Haga
authors.forename: Akira
authors.initials: A
authors.lastname: Hashimoto
authors.forename: Setsuya
authors.initials: S
authors.lastname: Aiba