title: Nucleotide embargo by SAMHD1: a strategy to block retroviral infection.
abstract: SAMHD1 (sterile alpha motif and histidine/aspartic acid (HD) domain-containing protein 1) has been identified as a novel HIV-1 restriction factor in myeloid cells and resting CD4+ T lymphocytes. SAMHD1 restriction is antagonized by the lentiviral protein Vpx. Here, we comment on the latest knowledge of SAMHD1 biology, focusing on how it regulates the pool of intracellular nucleotides to control HIV replication. We discuss how HIV restriction by SAMHD1 and viral counter-restriction mechanisms may suggest new strategies for therapeutic intervention.
authors.affiliation: IrsiCaixa, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pauls
authors.forename: Ester
authors.initials: E
authors.lastname: Ballana
authors.forename: José A
authors.initials: JA
authors.lastname: Esté
mesh_terms: D015497:HIV-1 / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism*; D009711:Nucleotides / Q000378:metabolism*; D000076106:SAM Domain and HD Domain-Containing Protein 1; D054334:Viral Regulatory and Accessory Proteins / Q000378:metabolism*; D037521:Virulence Factors / Q000378:metabolism; D014779:Virus Replication
chemical_list: D009711:Nucleotides; D054334:Viral Regulatory and Accessory Proteins; D037521:Virulence Factors; D000076106:SAM Domain and HD Domain-Containing Protein 1; C484280:SAMHD1 protein, human; D020559:Monomeric GTP-Binding Proteins