title: [A case of primary neuroendocrine carcinoma of the bile duct].
abstract: A 74-year-old man presented to a physician with a chief complaint of jaundice. He was diagnosed with bile duct carcinoma and admitted to our hospital. Laboratory data revealed abnormally elevated levels of total bilirubin, serum hepatic transaminase, and CA19-9. Endoscopic retrograde cholangiopancreatography revealed neoplastic stenosis from the hilus hepatis to the common bile duct. Abdominal computed tomography (CT) revealed an enhancing tumor in the hilus hepatis bile duct, and positron emission tomography-CT (PET-CT) revealed abnormal fluorodeoxyglucose accumulation in the tumor. Under a diagnosis of hilar cholangiocarcinoma, the patient underwent an extended right hepatectomy and left hepatico -jejunostomy. Immunohistochemically, the tumor cells were positive for neuroendocrine markers such as chromogranin A, synaptophysin, and CD56. The tumor was diagnosed as primary neuroendocrine carcinoma of the bile duct. The patient exhibited multiple liver metastasis 6 months after the operation. Transcatheter arterial chemoembolization (TACE) was performed for the liver metastasis. Although TACE exerted a cytoreductive effect temporarily, multiple liver abscesses developed. The patient died of liver failure 16 months after the operation. We report this rare case of primary neuroendocrine carcinoma of the bile duct.
authors.affiliation: Dept. of Surgery, Kansai Rosai Hospital, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Hamanaka
authors.forename: Shin
authors.initials: S
authors.lastname: Nakahira
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Mukai
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kanemura
authors.forename: Chieko
authors.initials: C
authors.lastname: Uchiyama
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Okishiro
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeno
authors.forename: Rei
authors.initials: R
authors.lastname: Suzuki
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Chiyomi
authors.initials: C
authors.lastname: Egawa
authors.forename: Ken
authors.initials: K
authors.lastname: Nakata
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Miki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kato
authors.forename: Teruaki
authors.initials: T
authors.lastname: Nagano
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nakatsuka
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Tamura
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications / Q000628:therapy*; D018278:Carcinoma, Neuroendocrine / Q000150:complications / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D017809:Fatal Outcome; D006801:Humans; D007565:Jaundice / Q000209:etiology; D008297:Male