title: A finite difference method for estimating second order parameter sensitivities of discrete stochastic chemical reaction networks.
abstract: We present an efficient finite difference method for the approximation of second derivatives, with respect to system parameters, of expectations for a class of discrete stochastic chemical reaction networks. The method uses a coupling of the perturbed processes that yields a much lower variance than existing methods, thereby drastically lowering the computational complexity required to solve a given problem. Further, the method is simple to implement and will also prove useful in any setting in which continuous time Markov chains are used to model dynamics, such as population processes. We expect the new method to be useful in the context of optimization algorithms that require knowledge of the Hessian.
authors.affiliation: Department of Mathematics, University of Wisconsin, Madison, Wisconsin 53706, USA. skubak@math.wisc.edu
authors.forename: Elizabeth Skubak
authors.initials: ES
authors.lastname: Wolf
authors.forename: David F
authors.initials: DF
authors.lastname: Anderson
mesh_terms: D000465:Algorithms; D005786:Gene Expression Regulation; D008390:Markov Chains; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013269:Stochastic Processes; D013997:Time Factors
chemical_list: D011506:Proteins; D012333:RNA, Messenger