title: [Animal experimentation of reimplantation of hypertonic saline-induced devitalized bone].
abstract: OBJECTIVE
  To observe the healing process and the change of biomechanical properties of  hypertonic saline-induced devitalized bone segment, so as to provide fundamental theory for clinical treatment.
  
  
  METHODS
  A model of New Zealand rabbit ulnar segments devitalized by hypertonic saline  was established and then reimplanted in situ. The ulnar specimens were taken for examination of X-rays, light microscope and three-point-bend test at  the end of 3, 6, 12, and 24 weeks postoperatively.
  
  
  RESULTS
  The devitalized bone healed at the end of 12 weeks in the X-ray film. The histological  examination showed that osteoblast multiplied and secreted osteoid gradually. The maximal breaking load of the devitalized bone continuously increased  and reached the top at the end of 24 weeks [control group (206.25±16.64) N vs. devitalized group (196.88±8.24) N, P>0.05].
  
  
  CONCLUSIONS
  The  devitalized bone healed through intramembranous and endochondral ossification, and the endochondral ossification predominated; the biomechanical  strength of devitalized bone continually increased as time lasted.
authors.affiliation: Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, China.
authors.forename: Chang-liang
authors.initials: CL
authors.lastname: Peng
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D005260:Female; D008297:Male; D011817:Rabbits; D012092:Replantation / Q000379:methods*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D014182:Transplantation, Autologous; D014457:Ulna / Q000187:drug effects* / Q000637:transplantation*
chemical_list: D012462:Saline Solution, Hypertonic