title: [Changes in EEG parameters in sleep and wakefulness in adult patients with drug-resistant localization-related epilepsy].
abstract: A study included 113 patients with localization-related epilepsy treated with antiepileptic drugs: 53 patients with drug-resistant (uncontrolled) form of the disease and 60 patients with controlled epileptic seizures. A comparison group included 53 patients with rare seizures not taking antiepileptic drugs. In the group of patients with uncontrolled localization-related epilepsy, the EEG monitoring of the sleep-wake cycle revealed more frequent regional interictal epileptiform discharges and increased α- and Β-activities during sleep compared to wakefulness. In patients with controlled seizures, there were the circadian changes in intra- and inter-hemispheric coherent relations in θ- и Β-bands. These relations remained stable when the sleep phase was changed to the wake phase.
authors.forename: O V
authors.initials: OV
authors.lastname: Grebeniuk
authors.forename: V M
authors.initials: VM
authors.lastname: Alifirova
authors.forename: M V
authors.initials: MV
authors.lastname: Svetlik
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D001611:Beta Rhythm; D002540:Cerebral Cortex / Q000503:physiopathology; D002940:Circadian Rhythm; D004351:Drug Resistance; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012894:Sleep Stages; D013826:Theta Rhythm; D014851:Wakefulness; D055815:Young Adult
chemical_list: D000927:Anticonvulsants