title: [Analysis of clinical prognostic factor for 99 patients with metastases of proximal femur].
abstract: OBJECTIVE
  To identify the clinical features and independent predictors of survival in patients with metastases of proximal femur.
  
  
  METHODS
  In the  study, 99 patients with proximal femoral metastatic lesions from 2003 to 2011 were analyzed retrospectively. The median age of patients was 56 years old  (15-87 years old), and the most common diagnosis was lung cancer, followed by breast cancer. The overall survival rate after bone metastases was  calculated using the Kaplan-Meier method. The prognostic factors were identified by univariate analysis using a Log-rank test and by multivariate  analysis using Cox proportional hazards regression models.
  
  
  RESULTS
  The 0.5-, 1- and 2-year survival rates were 55.7%, 24.3% and 7.7%,  respectively, with an average survival time of 10.34 months for patients with metastases of proximal femur. In univariate analysis, the number of bone  lesions, viscera metastases, and sensitivity to hormone therapy of primary tumor were correlated with prognosis. By multivariate analysis using Cox  regression, the dependence to hormone therapy of primary tumor was the only independent prognostic factor.
  
  
  CONCLUSIONS
  Patients with femoral  metastatic lesions can be operated safely and with acceptable complication rates. The prognostic factor analysis will help us to determine the appropriate  surgical treatment for proximal femoral metastases.
authors.affiliation: Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Ran
authors.initials: R
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D005266:Femoral Neoplasms / Q000401:mortality* / Q000556:secondary* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult