title: Natural history of irritable bowel syndrome.
abstract: BACKGROUND
  Chronic diarrhea and functional abdominal pain (FAP) in childhood could be an early manifestation of adult irritable bowel syndrome (IBS). The aim of this study was to investigate the presence of chronic functional digestive symptoms in childhood, interviewing adult patients diagnosed with IBS, in an attempt to establish a relationship between them.
  
  
  METHODS
  By means of a questionnaire, the history of colic, chronic diarrhea, functional abdominal pain, constipation and migraine in childhood, was analyzed in patients diagnosed with IBS according to the current Rome III criteria, and in control patients without known chronic digestive disorders. Fisher's exact test was used for comparison of frequencies.
  
  
  RESULTS
  The IBS study group was made up of 40 patients (24 women; average age, 33.03 years), and the control group by 40 adults (22 women; average age, 29.62 years). IBS-diagnosed adults spoke about a significantly higher prevalence of chronic diarrhea (32.5/7.5%; odds ratio [OR], 7.01; 95% confidence interval [CI]: 26.84-1.80), and FAP (37.5/15%; OR, 4.30; 95%CI: 12.67-1.43) in their childhood, than the control group. There were no differences in the presence of other childhood functional symptoms. Interestingly, the present patients, when asked about the onset of symptoms that led to the diagnosis of IBS, referred to them mostly beginning in adulthood, not linking their current diagnosis of IBS with their background in childhood.
  
  
  CONCLUSIONS
  In a proportion of adults with IBS the natural history of their symptoms probably began during their childhood.
authors.affiliation: University Clinic Hospital, Valladolid University, Valladolid, Spain. jmmarugan@telefonica.net
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Marugán-Miguelsanz
authors.forename: Mercedes
authors.initials: M
authors.lastname: Ontoria
authors.forename: Benito
authors.initials: B
authors.lastname: Velayos
authors.forename: Maria Carmen
authors.initials: MC
authors.lastname: Torres-Hinojal
authors.forename: Paz
authors.initials: P
authors.lastname: Redondo
authors.forename: Luis
authors.initials: L
authors.lastname: Fernández-Salazar
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003248:Constipation / Q000453:epidemiology / Q000209:etiology*; D003967:Diarrhea / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires; D055815:Young Adult