title: A genomic approach to the cryptic secondary metabolome of the anaerobic world.
abstract: A total of 211 complete and published genomes from anaerobic bacteria are analysed for the presence of secondary metabolite biosynthesis gene clusters, in particular those tentatively coding for polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). We investigate the distribution of these gene clusters according to bacterial phylogeny and, if known, correlate these to the type of metabolic pathways they encode. The potential of anaerobes as secondary metabolite producers is highlighted.
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstr. 11a, Jena, 07745, Germany.
authors.forename: Anne-Catrin
authors.initials: AC
authors.lastname: Letzel
authors.forename: Sacha J
authors.initials: SJ
authors.lastname: Pidot
authors.forename: Christian
authors.initials: C
authors.lastname: Hertweck
mesh_terms: D001419:Bacteria / Q000737:chemistry / Q000235:genetics; D001688:Biological Products; D006801:Humans; D055442:Metabolome; D015394:Molecular Structure; D010453:Peptide Synthases / Q000235:genetics / Q000378:metabolism; D048630:Polyketide Synthases / Q000235:genetics / Q000378:metabolism
chemical_list: D001688:Biological Products; D048630:Polyketide Synthases; D010453:Peptide Synthases