title: TRP channels: diagnostic markers and therapeutic targets for breast cancer?
abstract: Breast cancer is the most frequently occurring cancer in women and has the highest rate of mortality. Ion channels such as the transient receptor potential (TRP) channels could play a critical role in the development and progression of cancer. Although these channels are frequently and abundantly expressed in many tumors, their expression, activity, and roles in the context of breast cancer remain poorly understood. This review summarizes our current knowledge regarding TRP channels expressed in human breast tissue, primary human breast epithelial cells, and cell lines, the functional role of TRP channels during breast cancer cell growth and migration, as well as their relationship with clinical and pathological features.
authors.affiliation: University of Picardie Jules Verne, UFR Sciences, EA4667 Laboratory of Cell and Molecular Physiology, SFR CAP-SANTE, Amiens, France. ha-sciences@u-picardie.fr
authors.forename: Halima
authors.initials: H
authors.lastname: Ouadid-Ahidouch
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dhennin-Duthille
authors.forename: Mathieu
authors.initials: M
authors.lastname: Gautier
authors.forename: Henri
authors.initials: H
authors.lastname: Sevestre
authors.forename: Ahmed
authors.initials: A
authors.lastname: Ahidouch
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008321:Mammary Glands, Animal / Q000378:metabolism; D042361:Mammary Glands, Human / Q000378:metabolism; D058990:Molecular Targeted Therapy; D050051:Transient Receptor Potential Channels / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D050051:Transient Receptor Potential Channels