title: A simple competition assay to probe pentacopper(I)-thiolato cluster ligand exchange.
abstract: Two pentanuclear copper(I) thiolato clusters of the formula [Cu(5)(L)(3)](-) (L = pyridine-2,6-dimethanethiolate (L1), (1); 4-methylpyridine-2,6-dimethanethiolate (L2), (2)) were synthesized utilizing a single-step procedure, and their structures were characterized by X-ray crystallography. The aforementioned pentanuclear complexes possess an interesting propeller-like Cu(5)S(6) core where all Cu centers are three-coordinate. Electrospray ionization mass spectrometry (ESI-MS) investigation of the pentanuclear copper(I) thiolato clusters with added hetero-ligands demonstrated interesting ligand exchange behavior. The product distribution resulting from ligand exchange not only depended on the quantity of added ligand, but also was sensitive to the coordination ability of the ligand. The ESI-MS method used in this study can serve as a useful tool for probing exchange behavior in coordination metal complexes that cannot otherwise be determined by NMR.
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Yi-Hsun
authors.initials: YH
authors.lastname: Chen
authors.forename: Troy T Y
authors.initials: TT
authors.lastname: Lin
authors.forename: Hsuan-Ying
authors.initials: HY
authors.lastname: Chen
authors.forename: Chai-Lin
authors.initials: CL
authors.lastname: Kao
authors.forename: Hsing-Yin
authors.initials: HY
authors.lastname: Chen
authors.forename: Sodio C N
authors.initials: SC
authors.lastname: Hsu
authors.forename: James R
authors.initials: JR
authors.lastname: Carey
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
mesh_terms: D003300:Copper / Q000737:chemistry / Q000378:metabolism*; D018360:Crystallography, X-Ray; D008024:Ligands; D015335:Molecular Probes / Q000737:chemistry*; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013816:Thermodynamics
chemical_list: D008024:Ligands; D015335:Molecular Probes; D003300:Copper