title: The importance of imaging and physiology measurements in assessing the delivery of peripherally targeted aerosolized drugs.
abstract: Considerable recent effort has been directed towards developing new aerosol formulations and delivery devices that can target drugs to the lung periphery. In order to determine the efficacy of targeted drug therapy, it is essential that the peripheral lung region be adequately assessed. Imaging of the airways structure and pathology has greatly advanced in the last decade and this rate of growth is accelerating as new technologies become available. Lung imaging continues to play an important role in the study of the peripheral airways and, when combined with state-of-the-art lung function measurements and computational modeling, can be a powerful tool for investigating the effects of inhaled medication. This article focuses on recent strategies in imaging and physiological measurements of the lungs that allow the assessment of inhaled medication delivered to the periphery and discusses how these methods may help to further optimize and refine future aerosol delivery technology.
authors.affiliation: Airways Disease Section, National Heart and Lung Institute, Imperial College London & Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK.
authors.forename: Martyn F
authors.initials: MF
authors.lastname: Biddiscombe
authors.forename: Omar S
authors.initials: OS
authors.lastname: Usmani
mesh_terms: D000336:Aerosols; D001944:Breath Tests; D016503:Drug Delivery Systems; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D011877:Radionuclide Imaging; D012129:Respiratory Function Tests; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D000336:Aerosols