title: [Chromogranin A and neuroendocrine tumors].
abstract: Chromogranin A (CgA) is the most abundant granin in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). As a tumor marker is moderately sensitive and nonspecific. Despite the limitations of testing methods, which require careful interpretation, especially in the case of gastrinomas, patients treated with somatostatin analogues, and poorly differentiated tumors, it is the best tumor marker in GEP-NETs and may be of value in other tumors with neuroendocrine differentiation. CgA may be used as a marker in blood or tissue samples through immunohistochemical techniques. CgA levels correlate with tumor burden and extension and may be used for diagnosis and monitoring of GEP-NETs, especially midgut carcinoids and endocrine pancreatic tumors. It is also useful as a prognostic marker for detection of recurrence and monitoring of response to different treatments.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico San Carlos, Madrid, España. joseangeldiaz@mixmail.com
authors.forename: José Ángel
authors.initials: JÁ
authors.lastname: Díaz Pérez
authors.forename: Maria
authors.initials: M
authors.lastname: Currás Freixes
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D018276:Carcinoma, Medullary / Q000097:blood; D053379:Chromogranin A / Q000097:blood* / Q000502:physiology; D002864:Chromogranins / Q000145:classification / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D015408:Gastrinoma / Q000097:blood / Q000737:chemistry / Q000628:therapy; D005770:Gastrointestinal Neoplasms / Q000097:blood / Q000737:chemistry* / Q000628:therapy; D006801:Humans; D015592:Immunoradiometric Assay; D009363:Neoplasm Proteins / Q000097:blood*; D018358:Neuroendocrine Tumors / Q000097:blood / Q000737:chemistry* / Q000628:therapy; D009474:Neurons / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000097:blood / Q000737:chemistry* / Q000628:therapy; D010673:Pheochromocytoma / Q000097:blood; D011379:Prognosis; D011863:Radioimmunoassay; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000097:blood; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins; D009363:Neoplasm Proteins