title: [Successful treatment with lenalidomide plus dexamethasone for multiple myeloma complicated with systemic amyloidosis].
abstract: A 62-year-old woman diagnosed with asymptomatic IgG multiple myeloma in 1998 received distal gastrectomy because of abdominal fullness and was diagnosed with AL amyloidosis in 2009. She was referred to our hospital and further examination revealed amyloid depositions on the tongue, submandibular glands, heart, and gastrointestinal tract. Combination therapy of melphalan with dexamethasone was ineffective. She then received 13 courses of lenalidomide at 15 mg daily with weekly dexamethasone, which resulted in complete response with no detectable M-protein by immunofixation electrophoresis. Reduced-dose lenalidomide with dexamethasone is effective for patients with multiple myeloma complicated with AL amyloidosis.
authors.affiliation: Department of Hematology, Social Insurance Kyoto Hospital, Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Fuchida
authors.forename: Akira
authors.initials: A
authors.lastname: Okano
authors.forename: Mayumi
authors.initials: M
authors.lastname: Hatsuse
authors.forename: Satoshi
authors.initials: S
authors.lastname: Murakami
authors.forename: Harue
authors.initials: H
authors.lastname: Haruyama
authors.forename: Chihiro
authors.initials: C
authors.lastname: Shimazaki
mesh_terms: D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003907:Dexamethasone / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D000077269:Lenalidomide; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D013792:Thalidomide / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D013792:Thalidomide; D003907:Dexamethasone; D000077269:Lenalidomide