title: Clara Cell protein and myeloperoxidase levels in serum of subjects after exposure to fire smoke.
abstract: BACKGROUND
  Fire smoke inhalation is a well-recognized aetiological factor of airway injuries. The objective of this study was evaluation of Clara cell protein (CC16) and myeloperoxidase (MPO) concentrations in serum of patients after exposure to uncontrolled fire smoke.
  
  
  METHODS
  The study group consisted of 40 consecutive patients admitted to the Toxicology Unit after exposure to fire smoke. CC16 and MPO concentrations in their serum samples was measured on the day of admission to hospital and rechecked at the 2nd day and on the day of discharge. Patients also underwent routine toxicological diagnostic procedures applied in case of exposures, such as carboxyhaemoglobin (COHb) levels and blood lactate and urinary thiocyanate concentrations. The same diagnostic tests were performed in the control group consisting of 10 healthy subjects not exposed to fire smoke.
  
  
  RESULTS
  The average concentration of CC16 in the serum of subjects exposed to toxic factors was significantly higher at the day of admission in comparison with the respective values recorded on the 2nd day and on the day of discharge. The mean level of CC16 in the serum of the exposed group was also significantly higher than that in the control group. Tests for MPO concentrations in the serum did not reveal any significant changes in patients exposed to fire smoke.
  
  
  CONCLUSIONS
  As indicated, acute exposure to smoke induces injury at the alveolar level, which results in a transient increase of CC16 in serum of exposed subjects.
authors.affiliation: Toxicology Unit, Nofer Institute of Occupational Medicine, Lodz, Poland. annakrak@imp.lodz.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Krakowiak
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Hałatek
authors.forename: Ewa
authors.initials: E
authors.lastname: Nowakowska-Świrta
authors.forename: Renata
authors.initials: R
authors.lastname: Winnicka
authors.forename: Piotr
authors.initials: P
authors.lastname: Politański
authors.forename: Sylwia
authors.initials: S
authors.lastname: Świderska-Kiełbik
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D005260:Female; D005390:Fires; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress / Q000187:drug effects; D012016:Reference Values; D015208:Smoke Inhalation Injury / Q000097:blood* / Q000175:diagnosis; D014598:Uteroglobin / Q000097:blood*
chemical_list: D015415:Biomarkers; C556389:SCGB1A1 protein, human; D008315:Malondialdehyde; D014598:Uteroglobin