title: Highly water-soluble, near-infrared emissive BODIPY polymeric dye bearing RGD peptide residues for cancer imaging.
abstract: Near-infrared emissive BODIPY polymeric dye bearing cancer-homing cyclic arginine-glycine-aspartic acid (RGD) peptide residues (polymer B) was prepared by post-polymerization functionalization of BODIPY polymeric dye bearing bromo groups through tetra(ethylene glycol) tethered spacers (polymer A) with thiol-functionalized RGD cancer-homing peptide through thioether bonds under a mild basic condition. Polymer B possesses excellent water solubility, good photostability, biocompatibility and resistance to nonspecific interactions to normal endothelial cells, and can efficiently detect breast tumor cells through specific cooperative binding of cancer-homing RGD peptides to αvβ3 integrins of cancer cells while its parent polymer A without RGD residues fails to target cancer cells.
authors.affiliation: Department of Chemistry, Michigan Technological University, Houghton, MI 49931, United States.
authors.forename: Shilei
authors.initials: S
authors.lastname: Zhu
authors.forename: Jingtuo
authors.initials: J
authors.lastname: Zhang
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Janjanam
authors.forename: Jianheng
authors.initials: J
authors.lastname: Bi
authors.forename: Giri
authors.initials: G
authors.lastname: Vegesna
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Tiwari
authors.forename: Fen-Tair
authors.initials: FT
authors.lastname: Luo
authors.forename: Jianjun
authors.initials: J
authors.lastname: Wei
authors.forename: Haiying
authors.initials: H
authors.lastname: Liu
mesh_terms: D001896:Boron Compounds / Q000737:chemistry / Q000378:metabolism; D001940:Breast / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism; D061848:Optical Imaging; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D039302:Integrin alphaVbeta3; D009842:Oligopeptides; D011108:Polymers; D014867:Water; C047981:arginyl-glycyl-aspartic acid