title: The effect of chronic alcohol intoxication and smoking on the output of salivary immunoglobulin A.
abstract: The effect of chronic alcohol intoxication and smoking on the output of salivary immunoglobulin A (IgA) was studied in 37 volunteers: 17 male smoking patients after chronic alcohol intoxication (AS) and 20 control non-smoking male social drinkers (CNS). The DMFT index (decayed, missing, or filled teeth), gingival index and papilla bleeding index (PBI) were assessed. Concentration of IgA in saliva was determined by ELISA. Salivary flow (SF) and IgA output were significantly decreased in AS compared to CNS. There were no significant correlations between the amount of alcohol/cigarettes as well as the duration of alcohol intoxication/smoking, and SF or IgA output, nor between IgA level and SF. Gingival index was significantly higher in AS than in CNS, and was inversely correlated with IgA salivary level. The worsened periodontal state in smoking alcohol-dependent persons may result from diminished IgA protection of the oral tissues due to its decreased output.
authors.affiliation: Department of Psychiatry, Medical University of Białystok, Poland. napoleonwas@yahoo.com
authors.forename: Napoleon
authors.initials: N
authors.lastname: Waszkiewicz
authors.forename: Anna
authors.initials: A
authors.lastname: Zalewska
authors.forename: Slawomir Dariusz
authors.initials: SD
authors.lastname: Szajda
authors.forename: Magdalena
authors.initials: M
authors.lastname: Waszkiewicz
authors.forename: Agata
authors.initials: A
authors.lastname: Szulc
authors.forename: Alina
authors.initials: A
authors.lastname: Kepka
authors.forename: Beata
authors.initials: B
authors.lastname: Konarzewska
authors.forename: Alina
authors.initials: A
authors.lastname: Minarowska
authors.forename: Beata
authors.initials: B
authors.lastname: Zalewska-Szajda
authors.forename: Dorota
authors.initials: D
authors.lastname: Wilamowska
authors.forename: Danuta
authors.initials: D
authors.lastname: Waszkiel
authors.forename: Jerzy Robert
authors.initials: JR
authors.lastname: Ladny
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zwierz
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D016022:Case-Control Studies; D004245:DMF Index; D003771:Dental Papilla / Q000473:pathology; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D012463:Saliva / Q000378:metabolism*; D012907:Smoking / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D007071:Immunoglobulin A, Secretory