title: [Advance in studies on mechanism of active anti-tumor compounds from sponge].
abstract: With the decrease in land resources, marine resources open a new path for drug development, among which sponge is one of important marine biological resources. In recent years, many anti-tumor active compounds in new structures have been extracted and isolated from sponges. Targeted anti-tumor drugs from sponge become a new trend during the development of innovative drugs of marine resources. This essay summarizes the anti-tumor mechanism of sponge's active compounds and its related synthetics on the basis of its various anti-tumor targets including cytoskeleton (microtubule and actin), protein kinases (cyclin dependent kinase and aurora kinase), DNA synthesis and relevant enzymeso, growth microenvironment for tumor tissues and the immune system. Additionally, it also briefs relevant clinical studies.
authors.affiliation: Clinical Pharmacology Center, Third Xiangya Hospital of Central South University, Changsha 410013, China. yangfeng0711@126.com
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
authors.forename: Zhi-jun
authors.initials: ZJ
authors.lastname: Huang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D003599:Cytoskeleton / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007155:Immunologic Factors; D011480:Protease Inhibitors