title: [Targeting cancer antigen (MAGE-A4, NY-ESO -1) for immunotherapy].
abstract: Cancer/testis (CT) antigen is a group of antigens that are expressed in a wide variety of malignant tumors but not in normal adult tissues except for testis. Since CT antigens are immunogenic and highly restricted to tumors, they are considered as ideal targets for cancer immunotherapy. Many clinical studies targeting CT antigens have been tested. Here we review the history and the recent progress of clinical studies targeting MAGE family and NY-ESO-1 including our trials.
authors.affiliation: Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine.
authors.forename: Naoko
authors.initials: N
authors.lastname: Imai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ikeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiku
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*; D009363:Neoplasm Proteins / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D013737:Testis / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; C104948:CTAG1B protein, human; C095204:MAGEA4 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins