title: FTO first intron rs1558902 variant and platelets count in white middle-aged women: prague pre- and post-menopausal females (3PMFs) study.
abstract: The polymorphisms within the FTO gene play an important role in the genetic determination of body weight and body mass index and have been associated with cardiovascular disease, but the causal mechanism is still a matter of debate. The possible effect on the platelet count as a marker of hemocoagulation status as a possible cardiovascular risk factor was suggested in Japanese population. We have analyzed both rs1558902 FTO polymorphism (T > A) and platelet counts in the Prague Pre and Post Menopausal Females (3PMFs) study, including those of 669 women (mean age, 55.7 ± 2.7 years). The frequencies of the FTO genotypes were similar to other populations (TT, 30.4%; TA, 48.1%; and AA, 21.5%). We have not detected a significant association between the FTO rs1558902 variant and platelet counts in white women (TT, 242 ± 55 × 10; TA, 246 ± 67 × 10; and AA, 247 ± 55 × 10; F[2.642] = 0.30, P = 0.75). At least in white persons, platelet count seems not to be a link between the FTO variation and risk of cardiovascular disease.
authors.affiliation: Institute for Clinical and Experimental Medicine, Videnska, Prague, Czech Republic. jahb@ikem.cz
authors.forename: Jaroslav A
authors.initials: JA
authors.lastname: Hubacek
authors.forename: Dana
authors.initials: D
authors.lastname: Dlouha
authors.forename: Vera
authors.initials: V
authors.lastname: Lanska
authors.forename: Petr
authors.initials: P
authors.lastname: Stavek
authors.forename: Libuse
authors.initials: L
authors.lastname: Pagacova
authors.forename: Ivana
authors.initials: I
authors.lastname: Kralova-Lesna
authors.forename: Jan
authors.initials: J
authors.lastname: Pitha
mesh_terms: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D001792:Blood Platelets; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics*; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D010976:Platelet Count; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause / Q000235:genetics*; D017697:Premenopause / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human