title: Optimal range of triglyceride values to estimate serum low density lipoprotein cholesterol concentration in Korean adults: the Korea National Health and Nutrition Examination Survey, 2009.
abstract: The aims of this study were to investigate the validity of Friedewald's formula and to propose a range of triglyceride values over which the formula can be used without significant error. This was a cross-sectional analysis of 1,929 subjects (946 males and 983 females) aged 20 yr and older using data of the Korea National Health and Nutrition Examination Survey in 2009. Estimated total number was considered to be 10,633,655 (5,846,384 males and 4,787,271 females). Calculated and directly-measured low density lipoprotein cholesterol (LDL-C) values were highly correlated (r = 0.96); however, significant differences were observed between the directly-measured and calculated LDL-C concentrations. Subjects in the underestimated group (10.5%) had higher dysmetabolic profiles than those in the overestimated group (11.4%). Although serum triglyceride level showed the greatest independent association with differences between the calculated and directly-measured LDL-C concentrations, no statistically significant differences were noted when triglyceride concentration was between 36 and 298 mg/dL (93.2%). In conclusion, Friedewald's formula accurately estimates directly-measured serum LDL-C concentration in Korean adults. However, the formula can be applied to subjects with serum triglyceride concentrations from 36 to 298 mg/dL without significant error.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea. khmcilyong@naver.com
authors.forename: You-Cheol
authors.initials: YC
authors.lastname: Hwang
authors.forename: Hong-Yup
authors.initials: HY
authors.lastname: Ahn
authors.forename: In-Kyung
authors.initials: IK
authors.lastname: Jeong
authors.forename: Kyu Jeung
authors.initials: KJ
authors.lastname: Ahn
authors.forename: Ho Yeon
authors.initials: HY
authors.lastname: Chung
mesh_terms: D000328:Adult; D044466:Asian People; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood* / Q000592:standards; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D012016:Reference Values; D012044:Regression Analysis; D056910:Republic of Korea; D014280:Triglycerides / Q000097:blood* / Q000592:standards
chemical_list: D008078:Cholesterol, LDL; D014280:Triglycerides