title: CC-chemokine CCL15 expression and possible implications for the pathogenesis of IgE-related severe asthma.
abstract: Airway inflammation is accompanied by infiltration of inflammatory cells and an abnormal response of airway smooth muscle. These cells secrete chemokines and express the cell surface chemokine receptors that play an important role in the migration and degranulation of inflammatory cells. Omalizumab is a monoclonal antibody directed against immunoglobulin E, and its blocking of IgE signaling not only reduces inflammatory cell infiltration mediated by the Th2 immune response but also inhibits other immune responses. The chemokine CCL15 is influenced by omalizumab, and the source of CCL15 has been reported to be airway smooth muscle cells and basophils. CCL15 binds to its receptor CCR1, which has been reported to be expressed by various inflammatory cells and also by airway smooth muscle cells. Therefore, CCL15/CCR1 signaling could be a target for the treatment of asthma. We review the role of CCL15 in the pathogenesis of asthma and also discuss the influence of IgE-mediated immunomodulation via CCL15 and its receptor CCR1.
authors.affiliation: Department of Pulmonary Medicine, Maebashi Red Cross Hospital, 3-21-36 Asahi-Cho, Gunma, Maebashi 371-0014, Japan. yasuos@med.gunma-u.ac.jp
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Kunio
authors.initials: K
authors.lastname: Dobashi
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001249:Asthma / Q000209:etiology*; D019742:Chemokines, CC / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D002986:Clinical Trials as Topic; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007371:Interferon-gamma / Q000502:physiology; D019402:Macrophage Inflammatory Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D000069444:Omalizumab; D012333:RNA, Messenger / Q000032:analysis; D054389:Receptors, CCR1 / Q000032:analysis; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D061067:Antibodies, Monoclonal, Humanized; C108814:CCL15 protein, human; C515300:CCR1 protein, human; D019742:Chemokines, CC; D019402:Macrophage Inflammatory Proteins; D012333:RNA, Messenger; D054389:Receptors, CCR1; D014409:Tumor Necrosis Factor-alpha; D000069444:Omalizumab; D007073:Immunoglobulin E; D007371:Interferon-gamma