title: Dramatic reduction of proteinuria in diabetic nephropathy by the use of spironolactone.
abstract: The addition of spironolactone to the combination of an ACE inhibitor, and ARB, and a direct renin inhibitor brought about dramatic and sustained reversal of 4-plus proteinuria in a patient with diabetes mellitus and hypertension. Spironolactone may be a valuable addition to the therapeutic armamentarium for such patients, with the caveat that the spironolactone dose should be increased gradually and with frequent monitoring of the serum potassium level.
authors.forename: Harry W
authors.initials: HW
authors.lastname: Floyd
mesh_terms: D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000652:urine; D004232:Diuretics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000188:drug therapy*; D013148:Spironolactone / Q000627:therapeutic use*
chemical_list: D004232:Diuretics; D013148:Spironolactone