title: Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature.
abstract: Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.
authors.affiliation: Centro de Transplante de Medula Óssea, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil.
authors.forename: Luize
authors.initials: L
authors.lastname: Otero
authors.forename: Daiane Correa
authors.initials: DC
authors.lastname: de Souza
authors.forename: Rita
authors.initials: R
authors.lastname: de Cássia Tavares
authors.forename: Bernadete Evangelho
authors.initials: BE
authors.lastname: Gomes
authors.forename: Telma França
authors.initials: TF
authors.lastname: Padilha
authors.forename: Luiz Fernando
authors.initials: LF
authors.lastname: Bouzas
authors.forename: Teresa
authors.initials: T
authors.lastname: de Souza Fernandez
authors.forename: Eliana
authors.initials: E
authors.lastname: Abdelhay