title: Obesity and appetite-related hormones.
abstract: OBJECTIVE
  Alterations of hormones involved in food intake can lead to obesity and related-diseases. The aim of the present study was to measure plasma levels of appetite-related hormones: insulin, leptin, adiponectin, acylated ghrelin, and cortisol in connection with eating behaviors among obese and non-obese women.
  
  
  METHODS
  The present study was performed in 53 non-obese and 33 obese Thai women (BMI < 23 and > or = 25 kg/m2 respectively), aged 25 to 45 years. Saliva and fasting blood samples were collected for hormone measurements. Subjects 'eating behavior was evaluated using Thai version of the Three-factor eating questionnaire (TFEQ) and their stress status was assessed by the Thai stress test (TST).
  
  
  RESULTS
  In comparison to non-obese individuals, obese women showed higher disinhibition eating, plasma glucose, insulin, HOMA insulin resistance index, leptin, and triglyceride levels but lesser plasma adiponectin and HDLC. Lower adiponectin was directly associated with higher disinhibition eating. Plasma leptin related positively to fat mass and insulin resistance but negatively to acylated ghrelin level. The trend towards increased acylated ghrelin after adjusted for age, obesity and eating behaviors was shown in stress women.
  
  
  CONCLUSIONS
  Increased insulin resistance, high leptin, and reduced adiponectin accompanied with disinhibition eating have been detected in obese women.
authors.affiliation: Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. supornpim.che@mahidol.ac.th
authors.forename: Supornpim
authors.initials: S
authors.lastname: Chearskul
authors.forename: Suwattanee
authors.initials: S
authors.lastname: Kooptiwut
authors.forename: Sudaporn
authors.initials: S
authors.lastname: Pummoung
authors.forename: Siriporn
authors.initials: S
authors.lastname: Vongsaiyat
authors.forename: Malika
authors.initials: M
authors.lastname: Churintaraphan
authors.forename: Namoiy
authors.initials: N
authors.lastname: Semprasert
authors.forename: Smarn
authors.initials: S
authors.lastname: Onreabroi
authors.forename: Sucheera
authors.initials: S
authors.lastname: Phattharayuttawat
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000704:Analysis of Variance; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D005247:Feeding Behavior; D005260:Female; D054439:Ghrelin / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D011863:Radioimmunoassay; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D013785:Thailand; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D014280:Triglycerides; D006854:Hydrocortisone