title: [A case of drug resistant recurrent gastrointestinal stromal tumor treated surgically by resection, partial hepatectomy and diaphragmectomy].
abstract: This 69-year-old man underwent a partial jejunectomy for gastrointestinal stromal tumor(GIST) at the age of 60, and subsequently hepatectomy of segment 5, 6, 7 for liver metastasis of GIST a year later. An irregular mass close to the cutting stump of the liver, and a mass that showed enhanced-effect at segment 4 was discovered 28 months after hepatectomy. In order to treat this second recurrence, we administered imatinib and sunitinib sequentially. The tumor subsequently became drug-resistant, so we removed it surgically together with the liver and a portion of right diaphragm, and a tumor in segment 4. The patient shows no recurrent sign 4 months after surgery. This case suggests that surgical resection should be considered for partially drug resistant GIST.
authors.affiliation: Dept. of Surgical Oncology, Kanazawa Medical University, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Ueda
authors.forename: Emi
authors.initials: E
authors.lastname: Morioka
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kaida
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Tomita
authors.forename: Toshio
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Yukako
authors.initials: Y
authors.lastname: Ohno
authors.forename: Miki
authors.initials: M
authors.lastname: Noguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Funaki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kinami
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Omote
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nakano
authors.forename: Takeo
authors.initials: T
authors.lastname: Kosaka
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Minato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takamura
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001549:Benzamides; D003131:Combined Modality Therapy; D003964:Diaphragm / Q000601:surgery*; D019008:Drug Resistance, Neoplasm; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000601:surgery*; D006498:Hepatectomy; D006801:Humans; D000068877:Imatinib Mesylate; D007211:Indoles / Q000008:administration & dosage; D007580:Jejunal Neoplasms / Q000188:drug therapy / Q000601:surgery*; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008297:Male; D010534:Peritoneal Neoplasms / Q000556:secondary / Q000601:surgery*; D010879:Piperazines / Q000008:administration & dosage; D011743:Pyrimidines / Q000008:administration & dosage; D011758:Pyrroles / Q000008:administration & dosage; D012008:Recurrence; D000077210:Sunitinib
chemical_list: D001549:Benzamides; D007211:Indoles; D010879:Piperazines; D011743:Pyrimidines; D011758:Pyrroles; D000068877:Imatinib Mesylate; D000077210:Sunitinib