title: Herpes simplex virus encephalitis: toll-free access to the brain.
abstract: Herpes simplex encephalitis (HSE) is a devastating infection of the central nervous system (CNS). Lafaille et al. (2012) show that susceptibility to HSE is due to mutations in Toll-like receptor response pathways that directly reduce the intrinsic resistance of neurons and other cells in the CNS to HSV infection.
authors.affiliation: Geisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, One Medical Center Drive, Lebanon, NH 03756, USA. david.a.leib@dartmouth.edu
authors.forename: David A
authors.initials: DA
authors.lastname: Leib
mesh_terms: D001921:Brain; D002490:Central Nervous System / Q000473:pathology*; D004660:Encephalitis; D018259:Herpesvirus 1, Human / Q000276:immunology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D018139:Simplexvirus; D051196:Toll-Like Receptor 3 / Q000172:deficiency*
chemical_list: D051196:Toll-Like Receptor 3