title: Assessment of GE food safety using '-omics' techniques and long-term animal feeding studies.
abstract: Despite the fact that a thorough, lengthy and costly evaluation of genetically engineered (GE) crop plants (including compositional analysis and toxicological tests) is imposed before marketing some European citizens remain sceptical of the safety of GE food and feed. In this context, are additional tests necessary? If so, what can we learn from them? To address these questions, we examined data from 60 recent high-throughput '-omics' comparisons between GE and non-GE crop lines and 17 recent long-term animal feeding studies (longer than the classical 90-day subchronic toxicological tests), as well as 16 multigenerational studies on animals. The '-omics' comparisons revealed that the genetic modification has less impact on plant gene expression and composition than that of conventional plant breeding. Moreover, environmental factors (such as field location, sampling time, or agricultural practices) have a greater impact than transgenesis. None of these '-omics' profiling studies has raised new safety concerns about GE varieties; neither did the long-term and multigenerational studies on animals. Therefore, there is no need to perform such long-term studies in a case-by-case approach, unless reasonable doubt still exists after conducting a 90-day feeding test. In addition, plant compositional analysis and '-omics' profiling do not indicate that toxicological tests should be mandatory. We discuss what complementary fundamental studies should be performed and how to choose the most efficient experimental design to assess risks associated with new GE traits. The possible need to update the current regulatory framework is discussed.
authors.affiliation: AgroParisTech, Chair of Evolutionary Genetics and Plant Breeding, 16, rue Claude-Bernard, 75005 Paris, France. agnes.ricroch@agroparistech.fr
authors.forename: Agnès E
authors.initials: AE
authors.lastname: Ricroch
mesh_terms: D000821:Animal Feed / Q000009:adverse effects; D000818:Animals; D059022:Food Safety / Q000379:methods*; D030841:Food, Genetically Modified / Q000009:adverse effects* / Q000592:standards*; D020869:Gene Expression Profiling; D006801:Humans; D030821:Plants, Genetically Modified / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D018675:Toxicity Tests / Q000662:veterinary