title: Non-Hodgkin lymphoma and GIST: molecular pathways and clinical expressions.
abstract: We report the case of a 64-year-old woman with a gastrointestinal stromal tumor and a diffuse large cell lymphoma. For this case, we conducted a literature review in an attempt to correlate these two neoplasms on a molecular basis. Diffuse large cell lymphoma is a subtype of non-Hodgkin lymphomas. The etiologic factor of these lymphomas is considered to be the mutations or allelic losses of the TP53 tumor suppressor gene and the overexpression of the bcl-2 oncogene. Gastrointestinal stromal tumors are mesenchymal tumors, which are typically defined by the expression of c-KIT (CD117) and CD34 genes in the tumor cells. Although there are references to dispersants in the literature about patients with both non-Hodgkin lymphoma and gastrointestinal stromal tumors, there is no common molecular pathway between these two diseases. In conclusion, there is no indication that these two neoplasms are relevant on a molecular basis.
authors.affiliation: 1st University Surgery Department, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
authors.forename: Michael
authors.initials: M
authors.lastname: Karanikas
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Machairiotis
authors.forename: Paul
authors.initials: P
authors.lastname: Zarogoulidis
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Stylianaki
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Corcoutsakis
authors.forename: Alexandros
authors.initials: A
authors.lastname: Mitrakas
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Touzopoulos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Lyratzopoulos
authors.forename: George
authors.initials: G
authors.lastname: Kouklakis
authors.forename: Manolis
authors.initials: M
authors.lastname: Spanoudakis
authors.forename: Alexandros
authors.initials: A
authors.lastname: Polychronidis