title: Decrease of total antioxidative capacity in developed low cardiac output syndrome.
abstract: BACKGROUND
  It has been known that cardiac surgery induces an oxidative stress. The persistent oxidative stress during reperfusion may lead to depressed myocardial function resulting in low cardiac output syndrome (LCOS) necessitating inotropic or intra-aortic balloon counterpulsation support. Total antioxidant capacity (TAC) is a measurement of oxidative stress in tissues. The purpose of this study was to examine the TAC differences during coronary artery bypass graft (CABG) operation in patients who have developed LCOS and who have not.
  
  
  METHODS
  Seventy-nine patients were enrolled in the study. Central venous blood samples were obtained immediately before surgery, during operation, and at the end of surgery to assess TAC. Clinical data regarding patient demographics and operative outcomes were prospectively collected and entered into our clinical database.
  
  
  RESULTS
  LCOS developed in 8 patients (10.12%). The TAC has decreased sharply in the LCOS patients compared with those who did not develop LCOS (P < 0.001) during operation. In addition, the receiver operating characteristic (ROC) area was 0.879.
  
  
  CONCLUSIONS
  TAC has decreased during operation in a significant proportion of patients undergoing isolated CABG, and this is more prominent and serious and might be an independent variable in patients who have developed LCOS. This may be related to intraoperative misadventure or inadequate myocardial antioxidative protection. Routine measurement of the TAC during operation may provide information for assessment of the LCOS development.
authors.affiliation: Özel Yaşam Hastanesi Life Hospital, Antalya, Turkey. dralper@msn.com
authors.forename: Alper Sami
authors.initials: AS
authors.lastname: Kunt
authors.forename: Mehmet Halit
authors.initials: MH
authors.lastname: Andac
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D002303:Cardiac Output, Low / Q000378:metabolism* / Q000601:surgery; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012372:ROC Curve; D013997:Time Factors
chemical_list: D000975:Antioxidants