title: A molecular insight of CTLA-4 in food allergy.
abstract: Food allergy is an immune provocation induced by certain food in susceptible individuals. Most of the food allergic manifestations are evident in the individual having impaired oral tolerance. In spite of worldwide prevalence, there is no permanent cure of food allergy. Food allergic reactions are complex immunological events that comprises of several immune molecules like IgE, IL-4, IL-13 and T-cells, therefore, researchers are trying to pick the correct molecule to find out pivotal therapeutic solutions. Being a key regulatory molecule in suppressing T-cells functional activities, cytotoxic T-cell lymphocyte antigen-4 (CTLA-4) or cluster of differentiation-152 (CD-152) has contributed a novel and revolutionary dimension toward therapeutic research of several diseases. This review focuses on different immunological and mechanistic perspectives of CTLA-4 in correlation with food allergy.
authors.affiliation: Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg Post Box No. 80, Lucknow 226001, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Kumar
authors.forename: Alok Kumar
authors.initials: AK
authors.lastname: Verma
authors.forename: Mukul
authors.initials: M
authors.lastname: Das
authors.forename: Premendra D
authors.initials: PD
authors.lastname: Dwivedi
mesh_terms: D000818:Animals; D060908:CTLA-4 Antigen / Q000276:immunology*; D005512:Food Hypersensitivity / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D018793:Interleukin-13 / Q000276:immunology*; D015847:Interleukin-4 / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; C508598:IL4 protein, human; D018793:Interleukin-13; D015847:Interleukin-4; D007073:Immunoglobulin E