title: Statistical optimization and fabrication of a press coated pulsatile dosage form to treat nocturnal acid breakthrough.
abstract: OBJECTIVE
  Present work focuses on the use of mimosa seed gum to develop a drug delivery system making combined use of floating and pulsatile principles, for the chrono-prevention of nocturnal acid breakthrough.
  
  
  METHODS
  The desired aim was achieved by fabricating a floating delivery system bearing time - lagged coating of Mimosa pudica seed polymer for the programmed release of Famotidine. Response Surface Methodology was the statistical tool that was employed for experiment designing, mathematical model generation and optimization study. A 3(2) full factorial design was used in designing the experiment.% weight ratio of mimosa gum to hydroxy propyl methyl cellulose in the coating combination and the coating weight were the independent variables, whereas the lag time and the cumulative % drug release in 360 minutes were the observed responses.
  
  
  RESULTS
  Results revealed that both the coating composition and the coating weight significantly affected the release of drug from the dosage form.
  
  
  CONCLUSIONS
  The optimized formulation prepared according to the computer generated software, Design-Expert(®) deciphered response which were in close proximity with the experimental responses, thus confirming the robustness as well as accuracy of the predicted model for the utilization of natural polymer like mimosa seed gum for the chronotherapeutic treatment of nocturnal acid breakthrough.
authors.affiliation: Meerut Institute of Engineering and Technology, NH-58, Baghpat Bypass, Meerut-250005, Uttar Pradesh, India. 0606850055vaibhav@gmail.com
authors.forename: Vaibhav
authors.initials: V
authors.lastname: Agarwal
authors.forename: Mayank
authors.initials: M
authors.lastname: Bansal
mesh_terms: D000863:Antacids / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D015738:Famotidine / Q000008:administration & dosage / Q000737:chemistry*; D031298:Mimosa; D053149:Plant Gums / Q000008:administration & dosage / Q000737:chemistry*; D012639:Seeds
chemical_list: D000863:Antacids; D003692:Delayed-Action Preparations; D053149:Plant Gums; D015738:Famotidine