title: Different prognosis of acute myeloid leukemia harboring monosomal karyotype with total or partial monosomies determined by FISH: retrospective PALG study.
abstract: A monosomal karyotype (MK) was identified by banding techniques (BT) in acute myeloid leukemia (AML). However, BT may be insufficient to determine the actual loss of a complete chromosome, especially in complex karyotypes. We have investigated the effect of monosomy type, total (MK-t) and partial (MK-p), reevaluated by FISH, on prognosis. We have found that complete remission rate and probability of overall survival at 1 year was higher in MK-p (n=27) than MK-t (n=15) group (40% vs. 15.4%, P=0.19 and 30% vs. 9%, P=0.046, respectively). Our results indicate for the first time that monosomy type influences the prognosis of MK-AML.
authors.affiliation: Department of Hematology, Medical University, Lodz, Poland. ewa.wawrzyniak@umed.lodz.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Wawrzyniak
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wierzbowska
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kotkowska
authors.forename: Monika
authors.initials: M
authors.lastname: Siemieniuk-Rys
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Robak
authors.forename: Wanda
authors.initials: W
authors.lastname: Knopinska-Posluszny
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Klonowska
authors.forename: Mariola
authors.initials: M
authors.lastname: Iliszko
authors.forename: Renata
authors.initials: R
authors.lastname: Woroniecka
authors.forename: Barbara
authors.initials: B
authors.lastname: Pienkowska-Grela
authors.forename: Anna
authors.initials: A
authors.lastname: Ejduk
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wach
authors.forename: Ewa
authors.initials: E
authors.lastname: Duszenko
authors.forename: Anna
authors.initials: A
authors.lastname: Jaskowiec
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Jakobczyk
authors.forename: Barbara
authors.initials: B
authors.lastname: Mucha
authors.forename: Joanna
authors.initials: J
authors.lastname: Kosny
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Pluta
authors.forename: Sebastian
authors.initials: S
authors.lastname: Grosicki
authors.forename: Jerzy
authors.initials: J
authors.lastname: Holowiecki
authors.forename: Olga
authors.initials: O
authors.lastname: Haus
mesh_terms: D000328:Adult; D000368:Aged; D002872:Chromosome Deletion; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009006:Monosomy / Q000235:genetics*; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult