title: Bilateral pre- and postcentral gyrus volume positively correlates with T2-SNR of putamen in healthy adults.
abstract: BACKGROUND
  The aim of the present study was to investigate the correlation between local gray matter volume and signal-to-noise ratio on T2-weighted imaging (T2-SNR) of putamen in healthy adults using two tools: voxel-based morphometry (VBM) treating age as a confounding covariate to control for age-related gray matter volume changes and high spatial resolution T1-weighted imaging acquired with a 3.0-T magnetic resonance (3T-MR) scanner.
  
  
  METHODS
  Contiguous sagittal T1-weighted images and axial T2-weighted images of the brain were obtained from 1,380 healthy participants. T2-SNR of putamen was defined as A/B, where A is the mean T2-weighted signal intensity (T2-SI) in the right and left sides of putamen, and B is the background noise. The software Statistical Parametric Mapping 5 was used for image segmentation. The association between T2-SNR of putamen and gray matter volume was assessed with VBM, treating age as a confounding covariate.
  
  
  RESULTS
  A significant positive correlation was obtained between T2-SNR of putamen and bilateral pre- and postcentral gyrus volume.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first VBM study to show an age-independent relationship between T2-SNR of putamen and bilateral pre- and postcentral gyrus volumes in healthy adults.
authors.affiliation: Department of Radiological Technology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. car6_pa2_rw@yahoo.co.jp
authors.forename: Masami
authors.initials: M
authors.lastname: Goto
authors.forename: Osamu
authors.initials: O
authors.lastname: Abe
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.forename: Tosiaki
authors.initials: T
authors.lastname: Miyati
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Takao
authors.forename: Naoto
authors.initials: N
authors.lastname: Hayashi
authors.forename: Harushi
authors.initials: H
authors.lastname: Mori
authors.forename: Akira
authors.initials: A
authors.lastname: Kunimatsu
authors.forename: Kenji
authors.initials: K
authors.lastname: Ino
authors.forename: Keiichi
authors.initials: K
authors.lastname: Yano
authors.forename: Kuni
authors.initials: K
authors.lastname: Ohtomo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000166:cytology*; D009929:Organ Size / Q000502:physiology; D010296:Parietal Lobe / Q000033:anatomy & histology*; D011699:Putamen / Q000033:anatomy & histology* / Q000502:physiology*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic