title: [The role of interleukin 1-beta in pathogenesis and treatment of recurrent suppurative rhinosinusitis].
abstract: The objective of the present work was to study specific immunogenetic characteristics of 1-beta interleukin (IL 1-beta) production and estimate the possibility of using recombinant IL 1-beta for the treatment of recurrent suppurative rhinosinusitis. It was shown that the low production of IL 1-beta attributable to the combination of genotypes +3953>T *C/*C and -511C>T *C/*TAND *t/*t is associated with a relapse of suppurative rhinosinusitis. The patients presenting with this disorder are in need of dispensary examination and repeated administration of recombinant IL 1 beta (betaleukin) during the period of exacerbation of suppurative rhinosinusitis.
authors.forename: N A
authors.initials: NA
authors.lastname: Aref'eva
authors.forename: L F
authors.initials: LF
authors.lastname: Aznabaeva
authors.forename: E R
authors.initials: ER
authors.lastname: Sharipova
mesh_terms: D002908:Chronic Disease; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use*; D011379:Prognosis; D011994:Recombinant Proteins; D012008:Recurrence; D012220:Rhinitis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D012852:Sinusitis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D013492:Suppuration / Q000188:drug therapy / Q000378:metabolism
chemical_list: D053583:Interleukin-1beta; D011994:Recombinant Proteins