title: High grade prostate intraepithelial neoplasia (PIN) is a PSA-independent risk factor for prostate cancer in African American men: results from a pilot study.
abstract: African American men (AAM) demonstrate increased prostate cancer incidence and mortality rates. We investigated known prostate cancer risk factors in AAM. Prostate specific antigen (PSA) and diagnosis of high grade prostatic intraepithelial neoplasia (PIN) were significant prostate cancer predictors. However, even including AAM with low PSA (<4ng/ml), those with PIN had significantly elevated risk, compared to men without PIN (83.3% vs. 6.9%, p<0.0001). In AAM diagnosed with PIN, PSA level was no longer significant (83.3% vs. 92.3%, p=0.593 respectively). Our results suggest that a history of PIN is highly predictive of prostate cancer in AAM, and help provide PSA-independent venues for screening.
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa FL33612, USA.
authors.forename: Ganna
authors.initials: G
authors.lastname: Chornokur
authors.forename: Gang
authors.initials: G
authors.lastname: Han
authors.forename: Richard
authors.initials: R
authors.lastname: Tanner
authors.forename: Hui-Yi
authors.initials: HY
authors.lastname: Lin
authors.forename: B Lee
authors.initials: BL
authors.lastname: Green
authors.forename: Julio
authors.initials: J
authors.lastname: Pow-Sang
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Phelan
mesh_terms: D044383:Black People; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011230:Precancerous Conditions / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000473:pathology*; D001741:Black or African American
chemical_list: D017430:Prostate-Specific Antigen