title: Assessment of quality of life in patients with non-operated pancreatic cancer after videothoracoscopic splanchnicectomy.
abstract: BACKGROUND
  Pancreatic tumours are a crucial medical issue. The majority of patients report sick in the late stage of carcinoma clinical advancement, which considerably limits the possibility of surgical treatment. Pancreatic cancer patients with no other alternative but palliative treatment constitute a large group.
  
  
  OBJECTIVE
  To assess pain intensity levels and quality of life of pancreatic cancer patients after videothoracoscopic splanchnicectomy.
  
  
  METHODS
  Between 2001 January and 2010 November in the Department of Thorax, General Surgery and Oncology of the Medical University of Lodz 262 patients with pancreatic tumours were hospitalized. In 121 cases grade 3 and grade 4 tumours were observed. Hundred and twenty-one videothoracoscopic procedures of sympathetic trunk and ganglion excision were performed in 89 patients.
  
  
  RESULTS
  Before the procedure the pain intensity level according to VAS was 5.66 (3.9-7.2; SD 1.24) in the trial group and 5.46 (4.1-7.1; SD 1.15) in the control group. The quality of life average assessment in both groups did not differ statistically (p = 1.07) and was 46.3 (32-66; SD 0.92) in patients before the operation and in the control group 50.3 (41-63; SD 0.75). On the 7(th) postoperative day the pain intensity on average was 2.33 (1.2-3.9; SD 0.78) and 4.57 (3.6-5.5; SD 0.69) respectively. One week after the procedure the quality of patients' life was estimated at 64.1 (39-83; SD 1.38) and in the control group at 52.2 (42-65; SD 0.71); the differences are significant (p < 0.05). Thirty days after the procedure 12 patients did not take any painkillers (13.5%), and in the others a considerable decrease of the taken drugs was observed. On average, the pain intensity was estimated at 1.78 (0.6-3.6; SD 0.68). The quality of life, on the other hand, improved considerably in relation to the state prior to the procedure, but increased insignificantly in relation to the state on the 7(th) postoperative day to 70.9 (52-88; SD 1.14).
  
  
  CONCLUSIONS
  Splanchnicectomy is a safe method of cancer pain treatment in patients with advanced pancreatic tumours. Videothoracoscopic excision of visceral nerve thoracic section contributes to the statistically significant decrease of cancer pain intensity and considerably improves the quality of patients' lives.
authors.affiliation: Department of Thorax, General Surgery and Oncology, Medical University, Lodz, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Smigielski
authors.forename: Lukasz
authors.initials: L
authors.lastname: Piskorz
authors.forename: Marcin
authors.initials: M
authors.lastname: Wawrzycki
authors.forename: Leszek
authors.initials: L
authors.lastname: Kutwin
authors.forename: Piotr
authors.initials: P
authors.lastname: Misiak
authors.forename: Marian
authors.initials: M
authors.lastname: Brocki