title: TnpPred: A Web Service for the Robust Prediction of Prokaryotic Transposases.
abstract: Transposases (Tnps) are enzymes that participate in the movement of insertion sequences (ISs) within and between genomes. Genes that encode Tnps are amongst the most abundant and widely distributed genes in nature. However, they are difficult to predict bioinformatically and given the increasing availability of prokaryotic genomes and metagenomes, it is incumbent to develop rapid, high quality automatic annotation of ISs. This need prompted us to develop a web service, termed TnpPred for Tnp discovery. It provides better sensitivity and specificity for Tnp predictions than given by currently available programs as determined by ROC analysis. TnpPred should be useful for improving genome annotation. The TnpPred web service is freely available for noncommercial use.
authors.affiliation: Center for Bioinformatics and Genome Biology, Fundación Ciencia para la Vida Y Facultad de Ciencias Biologicas, Universidad Andres Bello, Santiago, Chile ; Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Riadi
authors.forename: Cristobal
authors.initials: C
authors.lastname: Medina-Moenne
authors.forename: David S
authors.initials: DS
authors.lastname: Holmes