title: Immunohistological features in adenomatoid odontogenic tumor: review of the literature and first expression and mutational analysis of β-catenin in this unusual lesion of the jaws.
abstract: OBJECTIVE
  To investigate for the first time the immunohistochemical and mutational status of β-catenin in a mandibular case of adenomatoid odontogenic tumor (AOT) and to review the immunohistochemical expression data of various markers (cytokeratins, metalloproteinases, etc) in such a lesion.
  
  
  METHODS
  A case of follicular-type AOT in a young male patient was analyzed in regard to the immunohistochemical expression of β-catenin and mutations of the β-catenin gene (CTNNB1). Its expression is altered in some odontogenic tumors.
  
  
  RESULTS
  We found a strong cytoplasmic expression of β-catenin, but no molecular anomaly within the exon 3 of CTNNB1. β-catenin is considered to play a role in cell differentiation processes.
  
  
  CONCLUSIONS
  Our results were consistent with previous findings in ameloblastoma and malignant odontogenic tumors. However, β-catenin alterations had not been explored in AOT so far. Further studies are necessary to understand the specific regulation of β-catenin in the AOT pathogenesis.
authors.affiliation: Faculty of Dentistry, Nice-Sophia-Antipolis University, Nice, France. jeanclaudeh7@gmail.com
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Harnet
authors.forename: Florence
authors.initials: F
authors.lastname: Pedeutour
authors.forename: Hélène
authors.initials: H
authors.lastname: Raybaud
authors.forename: Damien
authors.initials: D
authors.lastname: Ambrosetti
authors.forename: Thibault
authors.initials: T
authors.lastname: Fabas
authors.forename: Tommaso
authors.initials: T
authors.lastname: Lombardi
mesh_terms: D000236:Adenoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D015820:Cadherins / Q000096:biosynthesis / Q000235:genetics; D004252:DNA Mutational Analysis; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007633:Keratins / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D008339:Mandibular Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020782:Matrix Metalloproteinases / Q000096:biosynthesis / Q000235:genetics; D009808:Odontogenic Tumors / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D051176:beta Catenin / Q000096:biosynthesis / Q000235:genetics*
chemical_list: C495270:CTNNB1 protein, human; D015820:Cadherins; D016326:Extracellular Matrix Proteins; D051176:beta Catenin; D007633:Keratins; D020782:Matrix Metalloproteinases