title: Measles in Bolivia: A 'honeymoon period'.
abstract: BACKGROUND
  Although measles is a highly infectious disease, the live measles vaccine provides protection for over 20 years, and immunity may be lifelong. This study assessed measles seroprevalence in schoolchildren in the Cochabamba region of Bolivia.
  
  
  METHODS
  A seroepidemiological survey of measles immunity in 5-16-year-old schoolchildren (n=441) living in the Cochabamba region of Bolivia was performed in March and April of 2010. Representative regional samples of school children from 14 schools were obtained. A parent-administered questionnaire collected sociodemographic and socio-economic status, and serum samples were tested for measles antibodies using an enzyme-linked fluorescent antibody test. The measles prevalence and corresponding 95% confidence intervals (CI) were calculated. A descriptive and bivariate analysis was performed using the ANOVA or the Kruskal-Wallis test according to whether the data were distributed normally (Kolmogorov-Smirnov test p-value<0.05) plus the chi-square test or Fisher's exact test as needed.
  
  
  RESULTS
  The global seroprevalence of measles was 69.61% (95% CI 65.32-73.90) and was higher in adolescents (84.16%, 95% CI 77.04-91.28) and Spanish speakers (74.74%, 95% CI 68.56-80.92). The seroprevalence did not differ according to socio-economic status, living area, or number of family members in the household.
  
  
  CONCLUSIONS
  This study found a high prevalence of measles susceptibility in Bolivian children. Thus, herd immunity may not have been established, and some outbreak could occur. Authorities should redress this situation before endemic measles transmission occurs nationally and regionally, and there is an urgent need to conduct more seroprevalence studies in the region.
authors.affiliation: Bellvitge Biomedical Research Institute IDIBELL, International Health Centre and Travel Medicine Clinic, Preventive Medicine Department, University Hospital of Bellvitge, Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907 Catalonia, Spain. cmasuet@bellvitgehospital.cat
authors.forename: Cristina
authors.initials: C
authors.lastname: Masuet-Aumatell
authors.forename: Josep Ma
authors.initials: JM
authors.lastname: Ramon-Torrell
authors.forename: Aurora
authors.initials: A
authors.lastname: Casanova-Rituerto
authors.forename: Marta
authors.initials: M
authors.lastname: Banqué Navarro
authors.forename: María Del Rosario
authors.initials: Mdel R
authors.lastname: Dávalos Gamboa
authors.forename: Sandra Lucía
authors.initials: SL
authors.lastname: Montaño Rodríguez
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D001838:Bolivia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006801:Humans; D032521:Immunity, Herd / Q000276:immunology; D008297:Male; D008457:Measles / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
chemical_list: D000914:Antibodies, Viral