title: [Our experiences of anal squamous cell carcinoma treated by chemoradiotherapy].
abstract: We reviewed the clinical records of 6 cases with anal squamous cell carcinoma to evaluate the clinical effectiveness of chemoradiotherapy (CRT). The radiotherapy consisted of 40 Gy delivered to the pelvis and bilateral inguinal lesion, and a perianal booster dose of 20 Gy, in fractions of 2.0 Gy per day, 5 days per week. 5-FU and mitomycin C were administrated 3 times every 4 weeks as standard chemotherapy. On the first day of radiation therapy, 750 mg/m2 of 5-FU in the form of a continuous 24-hour infusion for 5 days was given. On the first day of chemotherapy, 10 mg/m2 of mitomycin C was also given as a single bolus infusion. One aged patient with a T3 tumor was administrated oral S-1 during radiotherapy. Four patients had a T2 tumor, 1 had a T1 tumor, and 1 had a T3 tumor. One patient had metastases in the Virchow lymph node that originated from synchronous vaginal cancer. No patient had hematogenous metastases. Grade 2 adverse effects occurred in 3 patients, and Grade 3 in 1 patient, during CRT, but the completion of CRT was achieved in all 6 patients. All patients had complete response (CR) in the anal lesion after CRT. Only the patient with a T3 tumor who was administrated S- 1 showed signs of recurrence in the anal lesion. CRT is expected to be a safe and effective treatment for improving the prognosis of anal squamous carcinoma.
authors.affiliation: Dept. of Surgery, Fujita Health University, Japan.
authors.forename: Harunobu
authors.initials: H
authors.lastname: Sato
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Koide
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuoka
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Honda
authors.forename: Miho
authors.initials: M
authors.lastname: Shiota
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Endo
authors.forename: Shinji
authors.initials: S
authors.lastname: Matsuoka
authors.forename: Kohei
authors.initials: K
authors.lastname: Hatta
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mizuno
authors.forename: Koutarou
authors.initials: K
authors.lastname: Maeda
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D001005:Anus Neoplasms / Q000473:pathology / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging