title: Rapid-screening detection of acetildenafils, sildenafils and avanafil by ion mobility spectrometry.
abstract: Ion mobility spectrometry was used as a rapid screening tool for the detection of acetildenafils, sildenafils and avanafil within adulterated herbal supplement matrices. Acetildenafils show a tendency for partial fragmentation during the desorption/ionization process affording two peaks in the ion mobility spectrum in addition to the intact compound. The fragmentation appears to occur α to the carbonyl group along the CN bond attaching the piperazine moiety, producing a common fragment (K₀=1.0280 cm²V⁻¹s⁻¹) along with the respective piperazine fragment. The sildenafils and avanafil afford one molecular ion peak per compound.
authors.affiliation: US Food and Drug Administration, CDER Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, MO 63101, United States. Daniel.Mans@fda.hhs.gov
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Mans
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Callahan
authors.forename: Jamie D
authors.initials: JD
authors.lastname: Dunn
authors.forename: Connie M
authors.initials: CM
authors.lastname: Gryniewicz-Ruzicka
mesh_terms: D002243:Carbolines / Q000032:analysis / Q000737:chemistry; D002623:Chemistry Techniques, Analytical; D019587:Dietary Supplements / Q000032:analysis*; D005506:Food Contamination; D005513:Food Inspection / Q000379:methods*; D007093:Imidazoles / Q000032:analysis / Q000737:chemistry; D007536:Isomerism; D058986:Phosphodiesterase 5 Inhibitors / Q000032:analysis* / Q000737:chemistry; D010879:Piperazines / Q000032:analysis* / Q000737:chemistry; D011687:Purines / Q000032:analysis / Q000737:chemistry; D011743:Pyrimidines / Q000032:analysis* / Q000737:chemistry; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000032:analysis* / Q000737:chemistry; D000068581:Tadalafil; D053719:Tandem Mass Spectrometry; D014227:Triazines / Q000032:analysis / Q000737:chemistry; D000069058:Vardenafil Dihydrochloride; D014665:Vasodilator Agents / Q000032:analysis* / Q000737:chemistry
chemical_list: D002243:Carbolines; D007093:Imidazoles; D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D011743:Pyrimidines; D013450:Sulfones; D014227:Triazines; D014665:Vasodilator Agents; D000069058:Vardenafil Dihydrochloride; D000068581:Tadalafil; D000068677:Sildenafil Citrate; C553414:avanafil