title: Assessing the preferred solution conformation of an interacting sense-antisense (complementary) peptide pair.
abstract: Sense peptides and corresponding antisense peptides, are capable of making specific interactions. Such interactions may result from inter-peptide side-chain/side-chain contacts or because peptides adopt mutually complementary three-dimensional shapes. Using a combined (1)H NMR spectroscopy/molecular modeling approach to study the interactions between one sense peptide and its corresponding antisense peptide, data are produced that provide clear support for the former hypothesis.
authors.affiliation: Imperial College Genetic Therapies Centre, Department of Chemistry, Flowers Building, Armstrong Road, Imperial College London, London SW7 2AZ, UK.
authors.forename: James R
authors.initials: JR
authors.lastname: Pullen
authors.forename: John
authors.initials: J
authors.lastname: Dalmaris
authors.forename: Stefano A
authors.initials: SA
authors.lastname: Serapian
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Miller
mesh_terms: D016375:Antisense Elements (Genetics) / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation; D010455:Peptides / Q000737:chemistry*
chemical_list: D016375:Antisense Elements (Genetics); D010455:Peptides