title: Null genotype of GSTT1 contributes to esophageal cancer risk in Asian populations: evidence from a meta-analysis.
abstract: OBJECTIVE
  Glutathione S-transferase T1 (GSTT1), a phase-II enzyme, plays an important role in detoxification of carcinogen electrophiles. Many studies have investigated the association between GSTT1 polymorphism and esophageal cancer risk in Asian populations, but its actual impact is not clear owing to apparent inconsistencies among those studies. Thus, a meta-analysis was performed to explore the effect of GSTT1 polymorphism on the risk of developing esophageal cancer.
  
  
  METHODS
  A literature search of PubMed, Embase, and Wanfang databases up to August 2012 was conducted and 15 eligible papers were finally selected, involving a total of 1,626 esophageal cancer cases and 2,216 controls. We used the pooled odds ratio (OR) with its corresponding 95% confidence interval (95%CI) to estimate the association of GSTT1 polymorphism with esophageal cancer risk. Subgroup analyses and sensitivity analyses were performed to further identify the association.
  
  
  RESULTS
  Meta-analysis of total studies showed the null genotype of GSTT1 was significantly associated with an increased risk of esophageal cancer in Asians (OR=1.26, 95%CI=1.05-1.52, POR=0.015, I2=42.7%). Subgroup analyses by sample size and countries also identified a significant association. Sensitivity analysis further demonstrated a relationship of GSTT1 polymorphism to esophageal cancer risk in Asians.
  
  
  CONCLUSIONS
  The present meta-analysis of available data showed a significant association between the null genotype of GSTT1 and an increased risk of esophageal cancer in Asians, particularly in China.
authors.affiliation: Department of Oncology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Sheng-Ming
authors.initials: SM
authors.lastname: Yi
authors.forename: Gui-Yuan
authors.initials: GY
authors.lastname: Li
mesh_terms: D001208:Asia / Q000453:epidemiology; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase