title: Neuropeptide Y stimulation as primary target for preventive measures of maladaptative cardiovascular reactions in occupational chronic stress exposure.
abstract: Chronic stress may produce a decrease in central NPY expression and subjects exposed to it may prove hypersensitivity to a novel stressor with dysfunctions in the NPY system and cardiovascular maladaptation to stress, even hypertension. Upregulation of NPY expression may contribute to successful behavioral adaptation to stress by reducing cardiovascular tone and suppressing anxious behaviors. Adaptogens, a new class of metabolic regulators stimulate NPY expression and release. The aim of this study is to increase tolerance and adaptation to stress of hypersensitive to novel stressor, occupational chronic stress exposed subjects with cardiovascular maladaptation to mild new stressor using adaptogens as part of prevention protocol.
  
  
  METHODS
  40 military personnel with known cardiostressor reactional mode and occupational chronic stress exposure were exposed to mild novel stressor: occupational medicine routine evaluation and clinically assessed for maladaptative cardiovascular response prior and before application of 30 day prevention protocol. Employees were randomly split in two groups, one receiving standard prevention protocol (lifestyle counseling) plus adaptogens in multiple dose administration, twice daily and the other receiving only standard prevention protocol.
  
  
  RESULTS
  We found significant statistic differences in all cardiovascular parameters in adaptogen group and only in diastolic blood pressure in control group.
  
  
  CONCLUSIONS
  Adaptogens could be an important factor in successful prevention protocols of chronic occupational stress dysfunctions involving NPY systems.
authors.affiliation: University of Medicine and Pharmacy Grigore T. Popa Iasi School of Medicine.
authors.forename: Mălina
authors.initials: M
authors.lastname: Ciumaşu-Rîmbu
authors.forename: Livia
authors.initials: L
authors.lastname: Popa
authors.forename: Carmen
authors.initials: C
authors.lastname: Vulpoi
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000223:Adaptation, Psychological / Q000187:drug effects*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D016022:Case-Control Studies; D002908:Chronic Disease; D003376:Counseling / Q000379:methods; D028001:Eleutherococcus; D005638:Fruit; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D009478:Neuropeptide Y / Q000097:blood / Q000187:drug effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D018517:Plant Roots; D029771:Rhodiola; D018570:Risk Assessment; D032141:Schisandra; D013313:Stress Disorders, Post-Traumatic / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: C578624:ADAPT 232; D015415:Biomarkers; D009478:Neuropeptide Y; D010936:Plant Extracts