title: Children's Oncology Group's 2013 blueprint for research: renal tumors.
abstract: Renal malignancies are among the most prevalent pediatric cancers. The most common is favorable histology Wilms tumor (FHWT), which has 5-year overall survival exceeding 90%. Other pediatric renal malignancies, including anaplastic Wilms tumor, clear cell sarcoma, malignant rhabdoid tumor, and renal cell carcinoma, have less favorable outcomes. Recent clinical trials have identified gain of chromosome 1q as a prognostic marker for FHWT. Upcoming studies will evaluate therapy adjustments based on this and other novel biomarkers. For high-risk renal tumors, new treatment regimens will incorporate biological therapies. A research blueprint, viewed from the perspective of the Children's Oncology Group, is presented.
authors.affiliation: Division of Oncology, Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC 20010, USA. jdome@childrensnational.org
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Dome
authors.forename: Conrad V
authors.initials: CV
authors.lastname: Fernandez
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Mullen
authors.forename: John A
authors.initials: JA
authors.lastname: Kalapurakal
authors.forename: James I
authors.initials: JI
authors.lastname: Geller
authors.forename: Vicki
authors.initials: V
authors.lastname: Huff
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Gratias
authors.forename: David B
authors.initials: DB
authors.lastname: Dix
authors.forename: Peter F
authors.initials: PF
authors.lastname: Ehrlich
authors.forename: Geetika
authors.initials: G
authors.lastname: Khanna
authors.forename: Marcio H
authors.initials: MH
authors.lastname: Malogolowkin
authors.forename: James R
authors.initials: JR
authors.lastname: Anderson
authors.forename: Arlene
authors.initials: A
authors.lastname: Naranjo
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Perlman
mesh_terms: D017024:Chemotherapy, Adjuvant; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy*; D009392:Nephrectomy; D012106:Research