title: Repurposing of yunnan baiyao as an alternative therapy for minor recurrent aphthous stomatitis.
abstract: The study was designed to evaluate the efficacy and safety of an herbal extract of Yunnan Baiyao formulated in toothpaste as an alternative therapy for minor RAS. A randomized, double-blind, placebo-controlled clinical trial (from March 2010 to March 2011) was conducted on a cohort of 227 minor RAS patients. The toothpaste containing Yunnan Baiyao was used twice daily as part of the patient's routine oral hygiene for 5 days. An assessment of ulcerative size and pain was recorded on day 0 (baseline), day 3, and day 5. Any noted adverse reactions were recorded. All data were analyzed using the SAS software 8.0. As a result, the toothpaste containing Yunnan Baiyao began to present noticeable effectiveness on ulcer healing (ulcer size) by day 3 (27.5% versus 15.8%, P < 0.05), which further improved by day 5 when compared to the placebo (66.4% versus 50.0%, P = 0.01). A significant difference in alleviating pain was noted on day 5 for those who used the toothpaste containing Yunnan Baiyao (66.4% versus 51.8%, P < 0.05). No side effects were noted as a result of the Yunnan Baiyao. Therefore, Yunnan Baiyao may provide an alternative therapy for minor ulcers by promoting healing.
authors.affiliation: Department of Oral Medicine, School and Hospital of Stomatology, Peking University, Beijing 100081, China.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Guan
authors.forename: Ruiyang
authors.initials: R
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Hua
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Yan