title: Characterization of the deficit syndrome in drug-naive schizophrenia patients: the role of spontaneous movement disorders and neurological soft signs.
abstract: This study aimed to characterize the deficit syndrome in drug-naive schizophrenia patients and to examine the relationship between deficit features and primary neurological abnormalities. Drug-naive schizophrenia patients (n = 102) were examined at baseline for demographics, premorbid functioning, duration of untreated illness (DUI), psychopathology, neurological signs, and deficit symptoms, and reassessed at 1-year follow-up. Neurological abnormalities were examined before inception of antipsychotic medication and included four domains of spontaneous movement disorders (SMD) and four domains of neurological soft signs (NSS). Patients fulfilling the deficit syndrome criteria at the two assessments (n = 20) were compared with nondeficit patients (n = 82) across demographic, clinical, and neurological variables. Deficit and nondeficit groups showed similar demographic characteristics and levels of psychotic, disorganization, and depressive symptoms. Compared with nondeficit patients, deficit patients showed poorer premorbid adjustment, higher premorbid deterioration, a lengthier DUI, and much poorer functional outcome. Relative to the nondeficit patients, those with the deficit syndrome showed higher levels of SMD--excepting akathisia--and NSS. This association pattern was also evident for deficit and neurological ratings in the whole sample of schizophrenia patients. Parkinsonism, motor sequencing, and release signs were all independently related to the deficit syndrome. These findings confirm that the deficit/nondeficit categorization is replicable and reliable in first-admission patients and raise the possibility that premorbid deterioration, deficit symptoms, and neurological abnormalities represent a triad of manifestations that share common underlying neurobiological mechanisms. More specifically, the data are consistent with a neurodevelopmental model of deficit symptoms involving basal ganglia dysfunction.
authors.affiliation: To whom correspondence should be addressed; Psychiatry Section B, Complejo Hospitalario de Navarra, Irunlarrea 3, 31008 Pamplona, Spain; tel: +34 848 422488, fax: +34 848 429924, e-mail: victor.peralta.martin@cfnavarra.es.
authors.forename: Victor
authors.initials: V
authors.lastname: Peralta
authors.forename: Lucía
authors.initials: L
authors.lastname: Moreno-Izco
authors.forename: Ana
authors.initials: A
authors.lastname: Sanchez-Torres
authors.forename: Elena
authors.initials: E
authors.lastname: García de Jalón
authors.forename: Maria S
authors.initials: MS
authors.lastname: Campos
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Cuesta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015897:Comorbidity; D003863:Depression / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000145:classification / Q000453:epidemiology / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000145:classification / Q000453:epidemiology / Q000503:physiopathology*; D015995:Prevalence; D062706:Prodromal Symptoms; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000145:classification / Q000453:epidemiology / Q000503:physiopathology*; D012720:Severity of Illness Index; D013577:Syndrome; D055815:Young Adult