title: Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl)methyl)-1H-indole, a new alkaloid from a deep-sea-derived actinomycete Serinicoccus profundi sp. nov.
abstract: One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of  96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).
authors.affiliation: Luxembourg Public Research Center for Health (CRP-SANTE), 84 Val Fleuri, Luxembourg L-1526, Luxembourg. xianwen.yang@crp-sante.lu
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.forename: Gai-Yun
authors.initials: GY
authors.lastname: Zhang
authors.forename: Jian-Xi
authors.initials: JX
authors.lastname: Ying
authors.forename: Bing
authors.initials: B
authors.lastname: Yang
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Zhou
authors.forename: Andre
authors.initials: A
authors.lastname: Steinmetz
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Liu
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
mesh_terms: D000192:Actinomycetales / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D002460:Cell Line; D045744:Cell Line, Tumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008826:Microbial Sensitivity Tests / Q000379:methods; D009792:Oceans and Seas; D012623:Seawater / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D026121:Indole Alkaloids