title: [A case of interstitial lung disease associated with gemcitabine treatment in a patient with locally advanced pancreatic cancer following proton beam radiotherapy].
abstract: A 69-year-old woman who had locally advanced pancreatic cancer underwent proton beam radiotherapy(67.5 GyE/25 Fr) concurrent with gemcitabine chemotherapy (GEM 800 mg/m2 day 1, 8) at Hyogo Ion Beam Medical Center, followed by GEM chemotherapy (1,000 mg/m2 day 1, 8, 15/28 day)at Kobe University Hospital. She visited our hospital because she was suffering from dyspnea 212 days after first administration of GEM. A chest computed tomography revealed that infiltrations were spreading in the bilateral lung fields. A bronchoscopy showed diffuse alveolar hemorrhage. We diagnosed GEM related interstitial lung disease with diffuse alveolar hemorrhage. We introduced steroid pulse therapy (methylprednisolone 1 g/day) for 3 days followed by oral prednisolone (40 mg/day), which was tapered gradually. She recovered and was discharged on the 24th day after admission.
authors.affiliation: Dept. of Surgery, Kobe University Graduate School of Medicine, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Tanaka
authors.forename: Ippei
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Shinzeki
authors.forename: Hirochika
authors.initials: H
authors.lastname: Toyama
authors.forename: Sadaki
authors.initials: S
authors.lastname: Asari
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Goto
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Shirakawa
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamashita
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Sawa
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Ueno
authors.forename: Masanori
authors.initials: M
authors.lastname: Takahashi
authors.forename: Shinobu
authors.initials: S
authors.lastname: Tsuchida
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kido
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ajiki
authors.forename: Takumi
authors.initials: T
authors.lastname: Fukumoto
authors.forename: Yonson
authors.initials: Y
authors.lastname: Ku
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D061766:Proton Therapy / Q000009:adverse effects*; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine