title: Simple strategy to functionalize polymeric substrates via surface-initiated ATRP for biomedical applications.
abstract: The functionalization of polymer surfaces via surface-initiated atom transfer radical polymerization (ATRP) is of crucial importance to prepare various functional materials. It is generally complicated to conduct ATRP on different organic material surfaces. In this work, a facile photoinduced one-step method was first developed for the covalent immobilization of ATRP initiators on the C-H group-containing substrates such as biaxially oriented polypropylene (BOPP). The C-H bonds of precise location of inert polymer surfaces were readily transferred to bromoalkyl initiator, followed by ATRP of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and glycidyl methacrylate (GMA), respectively, to produce the resultant patterned BOPP-g-P(DMAEMA) and BOPP-g-P(GMA) films. The epoxy groups of the P(GMA) microdomains can be aminated for covalently coupling IgG, while the P(DMAEMA) microdomains were used for immobilizing IgG via electronic interactions. The resultant IgG-coupled microdomains could interact with the corresponding target proteins, anti-IgG.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Ministry of Education College of Materials Science & Engineering, Beijing University of Chemical Technology, Beijing, China 100029.
authors.forename: C Y
authors.initials: CY
authors.lastname: Li
authors.forename: F J
authors.initials: FJ
authors.lastname: Xu
authors.forename: W T
authors.initials: WT
authors.lastname: Yang
mesh_terms: D000937:Antigen-Antibody Reactions; D007074:Immunoglobulin G / Q000737:chemistry* / Q000276:immunology; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D007074:Immunoglobulin G; D011108:Polymers