title: [Targeted based therapies in metastatic breast cancer: future evolution].
abstract: Research on molecular alteration process mechanisms leading to cancerogenesis permitted the elaboration of many targeted therapies.  Some therapeutic classes appeared recently and are currently being tested, including HER-2 dimerization inhibitors. However, most of these therapies are mostly ineffective with monotherapy. Clinical trials are ongoing, testing their efficiency in association with other molecules of the therapeutic arsenal which is available in oncology. Nevertheless, breast cancer remains a pathology life-threatening, most of the time. Within this review will be introduced the most efficient of these targeted therapies, including their eventual association with other cytotoxic molecules.
authors.affiliation: Service de la Pharmacie à Usage Intérieur, Hôpital Sainte Marguerite, Marseille, France. lbelmondo@hotmail.fr
authors.forename: Laure
authors.initials: L
authors.lastname: Belmondo
authors.forename: Marc
authors.initials: M
authors.lastname: Montana
authors.forename: Christophe
authors.initials: C
authors.lastname: Curti
authors.forename: Maxime
authors.initials: M
authors.lastname: Crozet
authors.forename: Pascal
authors.initials: P
authors.lastname: Rathelot
authors.forename: Christine
authors.initials: C
authors.lastname: Penot-Ragon
authors.forename: Patrice
authors.initials: P
authors.lastname: Vanelle
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000628:therapy*; D002277:Carcinoma / Q000628:therapy*; D005260:Female; D006801:Humans; D008495:Medical Oncology / Q000379:methods / Q000639:trends*; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends*; D009362:Neoplasm Metastasis
chemical_list: D000970:Antineoplastic Agents