title: Molecular mechanism underlying anti-inflammatory and  anti-allergic activities of phytochemicals: an update.
abstract: The resort worldwide to edible medicinal plants for medical care has increased significantly during the last few years. Currently, there is a renewed interest in the search for new phytochemicals that could be developed as useful anti-inflammatory and anti-allergic agents to reduce the risk of many diseases. The activation of nuclear transcription factor-kappa B (NF-κB) has now been linked to a variety of inflammatory diseases, while data from numerous studies underline the importance of phytochemicals in inhibiting the pathway that activates this transcription factor. Moreover, the incidence of type I allergic disorders has been increasing worldwide, particularly, the hypersensitivity to food. Thus, a good number of plant products with anti-inflammatory and anti-allergic activity have been documented, but very few of these compounds have reached clinical use and there is scant scientific evidence that could explain their mode of action. Therefore, this paper intends to review the most salient recent reports on the anti-inflammatory and anti-allergic properties of phytochemicals and the molecular mechanisms underlying these properties.
authors.affiliation: Laboratory of Research on Local Animal Products, Ibn-Khaldoun University of Tiaret, Tiaret 14000, Algeria.
authors.forename: Yuva
authors.initials: Y
authors.lastname: Bellik
authors.forename: Laïd
authors.initials: L
authors.lastname: Boukraâ
authors.forename: Hasan A
authors.initials: HA
authors.lastname: Alzahrani
authors.forename: Balkees A
authors.initials: BA
authors.lastname: Bakhotmah
authors.forename: Fatiha
authors.initials: F
authors.lastname: Abdellah
authors.forename: Si M
authors.initials: SM
authors.lastname: Hammoudi
authors.forename: Mokrane
authors.initials: M
authors.lastname: Iguer-Ouada
mesh_terms: D018926:Anti-Allergic Agents / Q000737:chemistry / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D016328:NF-kappa B; D010936:Plant Extracts