title: TAFI gene polymorphisms in patients with cerebral venous thrombosis.
abstract: Gene polymorphisms of thrombin activatable fibrinolysis inhibition (TAFI) factor have been investigated in various studies in terms of etiology (recurrence) and treatment (fibrinolytic effect) of thrombus formation. Cerebral venous thrombosis (CVT) is a life-threatening disease observed in young persons. Fifty-nine patients with CVT and 100 healthy control subjects were enrolled in the case/control study. The association between TAFI gene polymorphisms -438G>A, +505A>G and +1040C>T and cerebral venous thrombosis was investigated. It was found that frequencies of polymorphic genotype and allele were not different in patients than in control group and that they were not significant for cerebral venous thrombosis.
authors.affiliation: Meram Medical Faculty, Neurology, Necmettin Erbakan University, Konya, Turkey. osmanserhattokgoz@gmail.com
authors.forename: Serhat
authors.initials: S
authors.lastname: Tokgoz
authors.forename: Ayse Gul
authors.initials: AG
authors.lastname: Zamani
authors.forename: Hatice Gul
authors.initials: HG
authors.lastname: Durakbasi-Dursun
authors.forename: Osman
authors.initials: O
authors.lastname: Yilmaz
authors.forename: Nurhan
authors.initials: N
authors.lastname: Ilhan
authors.forename: Sennur
authors.initials: S
authors.lastname: Demirel
authors.forename: Mithat
authors.initials: M
authors.lastname: Tavli
authors.forename: Alper
authors.initials: A
authors.lastname: Sinan
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002550:Cerebral Veins / Q000503:physiopathology*; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D051548:Histone Acetyltransferases / Q000235:genetics*; D006801:Humans; D020767:Intracranial Thrombosis / Q000235:genetics* / Q000473:pathology*; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D035381:TATA-Binding Protein Associated Factors / Q000235:genetics*; D014057:Tomography, X-Ray Computed; D035362:Transcription Factor TFIID / Q000235:genetics*; D055815:Young Adult
chemical_list: D035381:TATA-Binding Protein Associated Factors; D035362:Transcription Factor TFIID; D051548:Histone Acetyltransferases; C069001:TATA-binding protein associated factor 250 kDa