title: Hyaluronic acid concentrations in synovial fluid of dogs with different stages of osteoarthritis.
abstract: To compare hyaluronic acid (HA) concentrations measured in synovial fluid (SF) of joints with different stages of canine secondary osteoarthritis (OA), clinical-orthopedic, radiographic, macroscopic intra-operative and SF findings of 49 joints were assessed. The sum of single findings was correlated to HA concentrations measured by a commercially available ELISA. Joints were categorized into three OA-groups: non-osteoarthritic, mildly osteoarthritic, and severely osteoarthritic. A significant negative correlation was found between severity of OA and HA concentrations (r=-0.696; P<0.001). Median values of HA concentrations decreased with increasing severity of the disease. Statistically significant differences in HA concentrations were observed between the OA-groups (P<0.001). Due to overlapping values between groups, it was concluded that synovial HA concentrations may only indicate a trend of osteoarthritic disease activity, but is not suitable for staging the disease.
authors.affiliation: Small Animal Clinic, Faculty of Veterinary Medicine, Freie Universität Berlin, Oertzenweg 19 b, 14163 Berlin, Germany. hanna.plickert@vetmeduni.ac.at
authors.forename: H D
authors.initials: HD
authors.lastname: Plickert
authors.forename: A
authors.initials: A
authors.lastname: Bondzio
authors.forename: R
authors.initials: R
authors.lastname: Einspanier
authors.forename: A
authors.initials: A
authors.lastname: Tichy
authors.forename: L
authors.initials: L
authors.lastname: Brunnberg
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006820:Hyaluronic Acid / Q000032:analysis*; D007596:Joints / Q000473:pathology; D008297:Male; D010003:Osteoarthritis / Q000473:pathology / Q000662:veterinary*; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000737:chemistry*
chemical_list: D006820:Hyaluronic Acid