title: Hypertonic saline and desmopressin: a simple strategy for safe correction of severe hyponatremia.
abstract: BACKGROUND
  Prompt correction of severe hyponatremia is important, but correction also must be limited to avoid iatrogenic osmotic demyelination. Expert opinion recommends that serum sodium level not be increased by more than 10-12 mEq/L in any 24-hour period and/or 18 mEq/L in any 48-hour period. However, inadvertent overcorrection is common, usually caused by the unexpected emergence of a water diuresis.
  
  
  METHODS
  Quality improvement report.
  
  
  METHODS
  All 25 patients admitted to a community teaching hospital between October 1, 2008, and September 30, 2011, who were treated for serum sodium level <120 mEq/L with concurrently administered desmopressin and hypertonic saline solution.
  
  
  METHODS
  Concurrently administered desmopressin (1-2 µg parenterally every 6-8 hours) and hypertonic saline with weight-based doses adjusted to increase the serum sodium concentration by 6 mEq/L, avoiding inadvertent overcorrection of severe hyponatremia.
  
  
  RESULTS
  Rate of correction of hyponatremia, predictability of response to the combination, adverse events related to therapy.
  
  
  METHODS
  Rate of correction of hyponatremia at 4, 24, and 48 hours; administered dose of 3% saline solution, salt tablets, and potassium; predicted increase in serum sodium level.
  
  
  RESULTS
  Mean changes in serum sodium levels during the first and second 24 hours of therapy were 5.8 ± 2.8 (SD) and 4.5 ± 2.2 mEq/L, respectively, without correction by >12 mEq/L in 24 hours or >18 mEq/L in 48 hours and without a decrease during therapy. There was no significant difference between actual and predicted increases during the first 24 hours. There was no adverse effect associated with therapy.
  
  
  CONCLUSIONS
  Without concurrent controls, we cannot be certain that outcomes are improved. Balance studies were not performed.
  
  
  CONCLUSIONS
  Combined 3% saline solution and desmopressin appears to be a valid strategy for correcting severe hyponatremia, but studies comparing the regimen with other therapeutic strategies are needed.
authors.affiliation: Rochester General Hospital, Rochester, NY, USA.
authors.forename: Lonika
authors.initials: L
authors.lastname: Sood
authors.forename: Richard H
authors.initials: RH
authors.lastname: Sterns
authors.forename: John K
authors.initials: JK
authors.lastname: Hix
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Silver
authors.forename: Linlin
authors.initials: L
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000628:therapy*; D007177:Inappropriate ADH Syndrome; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*
chemical_list: D012462:Saline Solution, Hypertonic; D003894:Deamino Arginine Vasopressin