title: Urine neutrophil gelatinase-associated lipocalin predicts graft outcome up to 1 year after kidney transplantation.
abstract: BACKGROUND
  Several recent reports demonstrated the usefulness of new biomarkers in early prediction of delayed graft function (DGF) and graft recovery after kidney transplantation (KT). It is unknown, however, whether these biomarkers would predict long-term graft outcome. In this study, we examined whether the biomarkers including neutrophil gelatinase-associated lipocalin (NGAL) and liver-type fatty acid-binding protein (L-FABP) can predict 1-year graft outcome as well as short-term graft function especially in patients with early graft function (EGF).
  
  
  METHODS
  This was a single-center, prospective observational study. Urine samples at 0 hours and 2 and 6 days were obtained and the level of NGAL and L-FABP were measured.
  
  
  RESULTS
  Of the 69 KT recipients enrolled, seven developed DGF, and the remaining 62 patients were finally enrolled as EGF recipients. EGF recipients were additionally divided into immediate graft function (IGF, n = 48) and slow graft function (SGF, n = 14) groups. Urinary NGAL (u-NGAL) level on day 2, but not L-FABP nor serum creatinine, was significantly higher in SGF compared to IGF group. Higher day 2 u-NGAL level was associated with more frequent development of SGF and, in addition, with significantly lower 1-year estimated glomerular filtration rate (eGFR). In multivariate logistic regression analysis, day 2 u-NGAL was a significant, independent factor for predicting poor long-term graft function (1-year eGFR < 60 mL/min/1.73 m(2)).
  
  
  CONCLUSIONS
  This study demonstrates the possibility that u-NGAL might be useful in predicting adverse 1-year outcome as well as short-term graft function even in EGF patients.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Korea University Medical College, Seoul, Korea.
authors.forename: H M
authors.initials: HM
authors.lastname: Choi
authors.forename: K T
authors.initials: KT
authors.lastname: Park
authors.forename: J W
authors.initials: JW
authors.lastname: Lee
authors.forename: E
authors.initials: E
authors.lastname: Cho
authors.forename: S K
authors.initials: SK
authors.lastname: Jo
authors.forename: W Y
authors.initials: WY
authors.lastname: Cho
authors.forename: H K
authors.initials: HK
authors.lastname: Kim
mesh_terms: D000209:Acute-Phase Proteins / Q000652:urine*; D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000652:urine; D001706:Biopsy; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000652:urine*; D012044:Regression Analysis; D051437:Renal Insufficiency / Q000628:therapy* / Q000652:urine*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins