title: [Study of aniline's penetration capability through rats' complete skin in vitro and normal lab gloves].
abstract: OBJECTIVE
  To study the permeability of intact mouse abdominal skin to aniline and the protective capability of two typical lab gloves against aniline.
  
  
  METHODS
  A Franz diffusion cell was used to perform in vitro transdermal absorption test and glove permeation test for aniline (0.102 mg/ml and 0.010 mg/ml). The permeabilities of intact mouse abdominal skin and gloves to aniline were measured by high performance liquid chromatography-diode array detection.
  
  
  RESULTS
  The transdermal penetration of the two concentrations of aniline followed zero order kinetics within 12 h, exhibiting total aniline permeabilities within 24 h of 51.71% and 48.31%, respectively. The absorption liquid had an aniline concentration of at least 18 µg/L. The medical disposable latex glove could not stop the penetration of 0.010 mg/ml aniline, but the industrial natural latex glove could.
  
  
  CONCLUSIONS
  The penetration of 0.102 mg/ml and 0.010 mg/ml aniline through the mouse abdominal skin follows zero order kinetics within 12 h. The medical disposable latex glove cannot stop the penetration of 0.010 mg/ml aniline, but the industrial natural latex glove can.
authors.affiliation: Department of New drug Research and Development in Guangzhou University of Traditional Chinese Medicine, Guangzhou 510006, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Feng
authors.forename: Bai-yin
authors.initials: BY
authors.lastname: He
authors.forename: Xue-lan
authors.initials: XL
authors.lastname: Ye
authors.forename: Chang-qing
authors.initials: CQ
authors.lastname: Liu
authors.forename: You-liang
authors.initials: YL
authors.lastname: Xie
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Lai
authors.forename: Ying-jun
authors.initials: YJ
authors.lastname: Zhou
mesh_terms: D000814:Aniline Compounds / Q000493:pharmacokinetics* / Q000633:toxicity*; D000818:Animals; D017575:Gloves, Protective; D051379:Mice; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D000814:Aniline Compounds; C023650:aniline