title: Kiss your tail goodbye: the role of PARN, Nocturnin, and Angel deadenylases in mRNA biology.
abstract: PARN, Nocturnin and Angel are three of the multiple deadenylases that have been described in eukaryotic cells. While each of these enzymes appear to target poly(A) tails for shortening and influence RNA gene expression levels and quality control, the enzymes differ in terms of enzymatic mechanisms, regulation and biological impact. The goal of this review is to provide an in depth biochemical and biological perspective of the PARN, Nocturnin and Angel deadenylases. Understanding the shared and unique roles of these enzymes in cell biology will provide important insights into numerous aspects of the post-transcriptional control of gene expression. This article is part of a Special Issue entitled: RNA Decay mechanisms.
authors.affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Godwin
authors.forename: Shihoko
authors.initials: S
authors.lastname: Kojima
authors.forename: Carla B
authors.initials: CB
authors.lastname: Green
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Wilusz
mesh_terms: D000595:Amino Acid Sequence; D005095:Exoribonucleases / Q000737:chemistry / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics*; D011061:Poly A / Q000737:chemistry / Q000235:genetics; D017433:Protein Structure, Secondary; D020871:RNA Stability / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*
chemical_list: D005095:Exoribonucleases; D009687:Nuclear Proteins; D011061:Poly A; D012333:RNA, Messenger; D014157:Transcription Factors; C102804:nocturnin