title: Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis.
abstract: A direct α-functionalization of simple aldehydes under N-Heterocyclic Carbene (NHC) catalysis and direct generation of ester enolate equivalents from nonfunctionalized aldehydes are disclosed. The catalysis involves selective enolate generation from an oxidatively generated NHC-bounded ester intermediate as a key step. The ester enolate intermediates undergo stereoselective reactions with enones and trifluoromethyl ketones.
authors.affiliation: Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
authors.forename: Junming
authors.initials: J
authors.lastname: Mo
authors.forename: Ruojie
authors.initials: R
authors.lastname: Yang
authors.forename: Xingkuan
authors.initials: X
authors.lastname: Chen
authors.forename: Bhoopendra
authors.initials: B
authors.lastname: Tiwari
authors.forename: Yonggui Robin
authors.initials: YR
authors.lastname: Chi
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000447:Aldehydes; D006571:Heterocyclic Compounds; D007659:Ketones; C030011:carbene; D008697:Methane