title: Determinants of renal function at hospital discharge of patients treated with renal replacement therapy in the intensive care unit.
abstract: OBJECTIVE
  Identification of risk factors for impaired renal function at hospital discharge in critically ill patients with acute kidney injury (AKI) requiring renal replacement therapy (RRT).
  
  
  METHODS
  A single-center retrospective cohort study was performed evaluating demographic and clinical parameters as potential risk factors for a modest to severely impaired renal function at hospital discharge in patients with AKI requiring RRT in the intensive care unit.
  
  
  RESULTS
  Of the 353 patients in our cohort, 90 (25.5%) patients had pre-existing chronic kidney disease (CKD). An estimated glomerular filtration rate (eGFR) ≤60 mL min(-1) 1.73 m(-2) at hospital discharge occurred in 64.0% of which 63.7% without known renal impairment before hospital admission and 8.2% of all cases left the hospital dialysis-dependent. Multivariable logistic regression showed that age (OR = 1.051, P < .001), serum creatinine concentration at start of RRT (OR = 1.004, P < .001) and administration of iodine-containing contrast fluid (OR = 0.830, P = .045) were associated with an eGFR ≤60 mL min(-1) 1.73 m(-2). Furthermore, a medical history of CKD (OR = 5.865, P < .001) was associated with dialysis dependence.
  
  
  CONCLUSIONS
  Elderly and patients with pre-existing CKD are at a high risk for modest to severely impaired renal function at hospital discharge after AKI requiring RRT.
authors.affiliation: Department of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Gijs
authors.initials: G
authors.lastname: Fortrie
authors.forename: Susanne
authors.initials: S
authors.lastname: Stads
authors.forename: Hilde R H
authors.initials: HR
authors.lastname: de Geus
authors.forename: A B Johan
authors.initials: AB
authors.lastname: Groeneveld
authors.forename: Robert
authors.initials: R
authors.lastname: Zietse
authors.forename: Michiel G H
authors.initials: MG
authors.lastname: Betjes
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology / Q000401:mortality / Q000628:therapy*; D000328:Adult; D000367:Age Factors; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006305:Health Status Indicators; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge / Q000706:statistics & numerical data*; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D017582:Renal Replacement Therapy / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors
chemical_list: D003404:Creatinine