title: [Blue rubber bleb naevus syndrome].
abstract: Blue rubber bleb nevus syndrome (Bean syndrome) is a rare disease characterized by the presence of multiple vascular malformation of rubber-like consistence. This disease is of a genetic origin and most often is caused by sporadic mutation, however, exist reports on autosomal dominant type of heritance. Nevi are most frequently met in the skin and alimentary tract but may be present in all organs and tissues. The most frequent symptom of Bean syndrome is anaemia due to ferrum deficiency, which is a result of chronic hemorrhagia from vascular malformations in the alimentary tract. Vascular anomalies on the skin are usually asymptomatic. Other symptoms are less frequent and depend on the localisation of vascular changes and therefore patients with Bean syndrome require meticulous analysis of reported multiple - specialistic medical care.
authors.affiliation: Medical University of Wroclaw, Poland. katarzyna.akutko@gmail.com
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Akutko
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Krzesiek
authors.forename: Barbara
authors.initials: B
authors.lastname: Iwańczak
mesh_terms: D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D006801:Humans; D018329:Nevus, Blue / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*