title: Preferential solvation of thiophene and furan-2-carboxaldehyde phenylhydrazone derivatives in DMSO-water and DMSO-n-octanol mixtures.
abstract: The preferential solvation of thiophene- and furan-2-carboxaldehyde phenylhydrazone derivatives in DMSO-water and DMSO-n-octanol mixtures has been studied using visible absorption spectroscopy with a previous characterization of the electronic transitions by Time-Dependent Density Functional Theory (TDDFT) and solvatochromic study in several solvents with different hydrogen-bond donor capacity. The results indicate that the phenylhydrazones are preferentially solvated by clusters of DMSO-water existing in the solvent mixture and the dielectric enrichment as preferential solvation mechanism was discarded. A relation between local DMSO concentration with nitro groups and the electronegativity of the heteroatom of the five-membered ring was found. For DMSO-1-octanol mixtures, the results showed no preferential solvation.
authors.affiliation: Laboratorio de Caracterización Molecular y Biomolecular, Departamento de Investigación en Tecnología de Materiales y del Ambiente, Instituto Venezolano de Investigaciones Científicas, Avenida 74 con calle 14A, Maracaibo, Edo. Zulia, Bolivarian Republic of Venezuela. yalvaradofec@yahoo.com
authors.forename: Ysaías J
authors.initials: YJ
authors.lastname: Alvarado
authors.forename: Alfonso
authors.initials: A
authors.lastname: Ballestas-Barrientos
authors.forename: Néstor
authors.initials: N
authors.lastname: Cubillán
authors.forename: Miguel
authors.initials: M
authors.lastname: Morales-Toyo
authors.forename: Jelem
authors.initials: J
authors.lastname: Restrepo
authors.forename: Gladys
authors.initials: G
authors.lastname: Ferrer-Amado
mesh_terms: D020003:1-Octanol / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D004583:Electrons; D005663:Furans / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D012996:Solutions; D012997:Solvents / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013876:Thiophenes / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D005663:Furans; D006835:Hydrazones; D012996:Solutions; D012997:Solvents; D013876:Thiophenes; C012483:phenylhydrazone; D014867:Water; D020003:1-Octanol; C039281:furan; D004121:Dimethyl Sulfoxide