title: Nucleophilic addition of benzimidazoles to alkynyl bromides/palladium-catalyzed intramolecular C-H vinylation: synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines.
abstract: An efficient "one-pot" route for the synthesis of benzo[4,5]imidazo[2,1-a] isoquinolines has been developed via nucleophilic addition of 2-aryl benzimidazoles to alkynyl bromides and subsequent palladium-catalyzed intramolecular C-H vinylation.
authors.affiliation: Department of Chemistry and Chemical Engineering, College of Science, Northeast Forestry University, Harbin, 150040, P. R. China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Peng
authors.forename: Guoning
authors.initials: G
authors.lastname: Shang
authors.forename: Chunxia
authors.initials: C
authors.lastname: Chen
authors.forename: Zhongshuo
authors.initials: Z
authors.lastname: Miao
authors.forename: Bin
authors.initials: B
authors.lastname: Li
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006860:Hydrogen Bonding; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001562:Benzimidazoles; D001965:Bromides; D007546:Isoquinolines; D014753:Vinyl Compounds; D010165:Palladium