title: Survival of cystic fibrosis patients undergoing liver and liver-lung transplantations.
abstract: BACKGROUND
  We evaluated the outcome of combined liver-lung transplantation (L-LTx) in cystic fibrosis (CF) patients with liver transplantation (LTx) for CF liver disease.
  
  
  METHODS
  The United Network for Organ Sharing (UNOS) data were analyzed from October 1987 to August 2009.
  
  
  RESULTS
  Of 294 patients (210 children), 265 (90.1%) received an LTx and 29, an L-LTx. Patient survival was: adult LTx, 80%, 74%, and 67% at 1, 3, and 5 years, and L-LTx, 72%, 61.4%, and 61.4% (P = .7); pediatric LTx, 85%, 82%, and 74% at 1, 3, and 5 years, and L-LTx, 83%, 83%, and 83% (P = .4). Pediatric patients had a slight survival advantage over adults for LTx (P = .08). Graft survival, not affected by immunosuppression regimens, was similar to patient survival.
  
  
  CONCLUSIONS
  The outcome of L-LTx appears similar to LTx in CF providing support for the prospect of a combined transplant.
authors.affiliation: Georgetown Transplant Institute, Washington, DC 20007, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Desai
authors.forename: A
authors.initials: A
authors.lastname: Gruessner
authors.forename: S
authors.initials: S
authors.lastname: Habib
authors.forename: R
authors.initials: R
authors.lastname: Gruessner
authors.forename: K M
authors.initials: KM
authors.lastname: Khan
mesh_terms: D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000401:mortality* / Q000628:therapy*; D016208:Databases, Factual; D005260:Female; D006085:Graft Survival; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications / Q000628:therapy; D016031:Liver Transplantation / Q000379:methods*; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult