title: Synthesis, characterization, biological evaluation and QSAR of some Schiff base esters: promising new antitumor, antioxidant and anti-inflammatory agents.
abstract: We report the synthesis, characterization, biological evaluation and quantitative structure-activity relationship of some Schiff base esters as promising new antitumor, antioxidant and anti-inflammatory agents. The Schiff base esters were synthesized by two synthetic routes using variably substituted hydroxy benzaldehydes with para amino phenol in appreciable yields. All the newly synthesized esters have been characterized by (1)H-NMR,(.13)C-NMR, FT-IR techniques and elemental analysis. The synthesized esters were examined for antioxidant, antitumor and anti-inflammatory potentials through different bioassays and quantitative structure-activity relationship was studied. Bioassays showed encouraging results and indicated that some of these title compounds may have potential for further pharmacological investigations.
authors.affiliation: Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Asma
authors.initials: A
authors.lastname: Noureen
authors.forename: Samreen
authors.initials: S
authors.lastname: Saleem
authors.forename: Tabinda
authors.initials: T
authors.lastname: Fatima
authors.forename: Humaira Masood
authors.initials: HM
authors.lastname: Siddiqi
authors.forename: Bushra
authors.initials: B
authors.lastname: Mirza
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D002351:Carrageenan; D004249:DNA Damage; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D004952:Esters / Q000138:chemical synthesis* / Q000494:pharmacology*; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects; D010941:Plant Tumors / Q000382:microbiology; D021281:Quantitative Structure-Activity Relationship; D051381:Rats; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology*; D011198:Solanum tuberosum / Q000187:drug effects / Q000382:microbiology; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D004952:Esters; D012545:Schiff Bases; D002351:Carrageenan