title: Lesions to right prefrontal cortex impair real-world planning through premature commitments.
abstract: While it is well accepted that the left prefrontal cortex plays a critical role in planning and problem-solving tasks, very little is known about the role of the right prefrontal cortex. We addressed this issue by testing five neurological patients with focal lesions to right prefrontal cortex on a real-world travel planning task, and compared their performance with the performance of five neurological patients with focal lesions to left prefrontal cortex, five neurological patients with posterior lesions, and five normal controls. Only patients with lesions to right prefrontal cortex generated substandard solutions compared to normal controls. Examination of the underlying cognitive processes and strategies revealed that patients with lesions to right prefrontal cortex approached the task at an excessively precise, concrete level compared to normal controls, and very early locked themselves into substandard solutions relative to the comparison group. In contrast, the behavior of normal controls was characterized by a judicious interplay of concrete and abstract levels/modes of representations. We suggest that damage to the right prefrontal system impairs the encoding and processing of more abstract and vague representations that facilitate lateral transformations, resulting in premature commitment to precise concrete patterns, and hasty albeit substandard conclusions (because the space of possibilities has not been properly explored).
authors.affiliation: York University, Toronto, Canada. vgoel@yorku.ca
authors.forename: Vinod
authors.initials: V
authors.lastname: Goel
authors.forename: Oshin
authors.initials: O
authors.lastname: Vartanian
authors.forename: Angela
authors.initials: A
authors.lastname: Bartolo
authors.forename: Lila
authors.initials: L
authors.lastname: Hakim
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Ferraro
authors.forename: Valeria
authors.initials: V
authors.lastname: Isella
authors.forename: Ildebrando
authors.initials: I
authors.lastname: Appollonio
authors.forename: Silvia
authors.initials: S
authors.lastname: Drei
authors.forename: Paolo
authors.initials: P
authors.lastname: Nichelli
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology; D000368:Aged; D001288:Attention; D003071:Cognition / Q000502:physiology; D003627:Data Interpretation, Statistical; D004522:Educational Status; D056344:Executive Function / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006040:Goals; D006801:Humans; D007361:Intelligence Tests; D002532:Intracranial Aneurysm / Q000473:pathology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000293:injuries* / Q000473:pathology; D011340:Problem Solving / Q000502:physiology*; D020521:Stroke / Q000473:pathology / Q000523:psychology; D055815:Young Adult