title: [Drug releasing characteristics evaluation to multi-drug delivery system of tongmai pellets].
abstract: OBJECTIVE
  To establish the drug release method of multi-drug delivery system of tongmai pellets.
  
  
  METHODS
  The drug releasing characteristics were researched by HPLC and UV spectrophotometric method. The drug releasing characteristics of the multi-drug delivery system of tongmai pellets between single unit and multiple drug delivery system were evaluated by HPLC.
  
  
  RESULTS
  The four pellets release unit isoflavones pellets, tanshinone pellets, Sal pellets, chuanxiong acid by ultraviolet spectrophotometry and HPLC method of dissolution obtained similar curves, and the similarity factor f2 were 63.31, 81.59, 70.93, 68.08. The release unit after the formation of multiple drug delivery system had no influence on single unit.
  
  
  CONCLUSIONS
  Initial construction of multiple drug delivery system tongmai pellets improved the dissolution of insoluble components, the overall performance of the combination of rapid release and sustained release characteristics, in line with the design requirements.
authors.affiliation: Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. xiaoyu9456@sina.com
authors.forename: Dan-hong
authors.initials: DH
authors.lastname: Yu
authors.forename: Yang
authors.initials: Y
authors.lastname: Huang
authors.forename: Xiao-bin
authors.initials: XB
authors.lastname: Jia
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D004304:Dosage Forms; D016503:Drug Delivery Systems; D008516:Medicine, Chinese Traditional; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D004304:Dosage Forms; D004364:Pharmaceutical Preparations