title: Mitochondria as a source of reactive oxygen and nitrogen species: from molecular mechanisms to human health.
abstract: Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and damaging pathways in different tissues. In addition, mitochondria are an important target of reactive oxygen and nitrogen species. Here, we discuss basic mechanisms of mitochondrial oxidant generation and removal and the main factors affecting mitochondrial redox balance. We also discuss the interaction between mitochondrial reactive oxygen and nitrogen species, and the involvement of these oxidants in mitochondrial diseases, cancer, neurological, and cardiovascular disorders.
authors.affiliation: Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
authors.forename: Tiago R
authors.initials: TR
authors.lastname: Figueira
authors.forename: Mario H
authors.initials: MH
authors.lastname: Barros
authors.forename: Anamaria A
authors.initials: AA
authors.lastname: Camargo
authors.forename: Roger F
authors.initials: RF
authors.lastname: Castilho
authors.forename: Julio C B
authors.initials: JC
authors.lastname: Ferreira
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Kowaltowski
authors.forename: Francis E
authors.initials: FE
authors.lastname: Sluse
authors.forename: Nadja C
authors.initials: NC
authors.lastname: Souza-Pinto
authors.forename: Anibal E
authors.initials: AE
authors.lastname: Vercesi
mesh_terms: D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D026361:Reactive Nitrogen Species / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species