title: Midluteal serum progesterone concentration does not predict the outcome of pregnancy in women with unexplained recurrent miscarriage.
abstract: This retrospective observational study was performed to determine the predictive value of midluteal serum progesterone measurement on the subsequent pregnancy outcome in women with unexplained recurrent miscarriage after referral. This study involved women with unexplained recurrent miscarriage attending the recurrent miscarriage clinic between January 1992 and March 2011. A total of 132 women with unexplained recurrent miscarriage who conceived again within 12 months of midluteal serum progesterone measurement were analysed. Midluteal serum progesterone concentrations were compared between miscarriage and live birth groups. Also live birth rates were compared between higher and lower progesterone groups. Among 132 women studied, the serum progesterone concentrations (mean ± SE) in the live birth group (n=86) and miscarriage group (n=46) were 42.3 ± 2.4 nmol/l and 42.5 ± 3.2 nmol/l, respectively. In addition, using three different progesterone cut-off values (20, 30 and 40 nmol/l), the live birth and miscarriage rates were also not significantly different. The conclusion is that midluteal serum progesterone measurement does not predict the outcome of a subsequent pregnancy in women with unexplained recurrent miscarriage. This retrospective observational study was performed to determine the predictive value of midluteal serum progesterone measurement on the subsequent pregnancy outcome in women with unexplained recurrent miscarriage after referral. This study involved women with unexplained recurrent miscarriage attending the recurrent miscarriage clinic between January 1992 and March 2011. A total of 132 women with unexplained recurrent miscarriage who conceived again within 12 months of midluteal serum progesterone measurement were analysed. Midluteal serum progesterone values were compared between miscarriage and live birth groups. Also live birth rates were compared between higher and lower progesterone groups. Among 132 women studied, the serum progesterone concentration in the live birth group (n=86) and miscarriage group (n=46) were (mean ± SE) 42.3 ± 2.4 nmol/l and 42.5 ± 3.2 nmol/l, respectively. In addition, using three different progesterone cut-off values (20, 30 and 40 nmol/l), the live birth and miscarriage rates were also not significantly different. The conclusion is that midluteal serum progesterone measurement does not predict the outcome of a subsequent pregnancy in women with unexplained recurrent miscarriage.
authors.affiliation: Centre for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China. yyy306@126.com
authors.forename: Junhao
authors.initials: J
authors.lastname: Yan
authors.forename: Fenghua
authors.initials: F
authors.lastname: Liu
authors.forename: Xi
authors.initials: X
authors.lastname: Yuan
authors.forename: Sotirios H
authors.initials: SH
authors.lastname: Saravelos
authors.forename: Karen
authors.initials: K
authors.lastname: Cocksedge
authors.forename: Tin-Chiu
authors.initials: TC
authors.lastname: Li
mesh_terms: D000026:Abortion, Habitual / Q000097:blood*; D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D008183:Luteal Phase / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000097:blood*; D012189:Retrospective Studies
chemical_list: D011374:Progesterone