title: Nanomaterial-based functional scaffolds for amperometric sensing of bioanalytes.
abstract: Functional nanomaterials have emerged as promising candidates in the development of an amperometric sensing platform for the detection and quantification of bioanalytes. The remarkable characteristics of nanomaterials based on metal and metal oxide nanoparticles, carbon nanotubes, and graphene ensure enhanced performance of the sensors in terms of sensitivity, selectivity, detection limit, response time, and multiplexing capability. The electrocatalytic properties of these functional materials can be combined with the biocatalytic activity of redox enzymes to develop integrated biosensing platforms. Highly sensitive and stable miniaturized amperometric sensors have been developed by integrating the nanomaterials and biocatalyst with the transducers. This review provides an update on recent progress in the development of amperometric sensors/biosensors using functional nanomaterials for the sensing of clinically important metabolites such as glucose, cholesterol, lactate, and glutamate, immunosensing of cancer biomarkers, and genosensing.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India.
authors.forename: Ramendra Sundar
authors.initials: RS
authors.lastname: Dey
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Bera
authors.forename: C R
authors.initials: CR
authors.lastname: Raj
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000032:analysis; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D018698:Glutamic Acid / Q000032:analysis; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation / Q000379:methods; D019344:Lactic Acid / Q000032:analysis; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis; D014527:Uric Acid / Q000032:analysis
chemical_list: D001786:Blood Glucose; D014527:Uric Acid; D019344:Lactic Acid; D018698:Glutamic Acid; D002784:Cholesterol