title: Biocompatible nanocomposite for PET/MRI hybrid imaging.
abstract: A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid) linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2'-(7-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ligand for subsequent (68)Ga incorporation. A cell-based cytotoxicity assay has been employed to verify the in vitro cell viability of human pancreatic cancer cells exposed to this nanosystem. Finally, in vivo positron emission tomography-computerized tomography biodistribution studies in healthy animals were performed.
authors.affiliation: Department of Industrial Chemistry Toso Montanari. University of Bologna, Italy.
authors.forename: Erica
authors.initials: E
authors.lastname: Locatelli
authors.forename: Larraitz
authors.initials: L
authors.lastname: Gil
authors.forename: Liron Limor
authors.initials: LL
authors.lastname: Israel
authors.forename: Lorena
authors.initials: L
authors.lastname: Passoni
authors.forename: Maria
authors.initials: M
authors.lastname: Naddaka
authors.forename: Andrea
authors.initials: A
authors.lastname: Pucci
authors.forename: Torsten
authors.initials: T
authors.lastname: Reese
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gomez-Vallejo
authors.forename: Paolo
authors.initials: P
authors.lastname: Milani
authors.forename: Michela
authors.initials: M
authors.lastname: Matteoli
authors.forename: Jordi
authors.initials: J
authors.lastname: Llop
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Lellouche
authors.forename: Mauro Comes
authors.initials: MC
authors.lastname: Franchini
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis; D003287:Contrast Media / Q000138:chemical synthesis; D005710:Gallium Radioisotopes / Q000737:chemistry; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D049329:Nanostructures / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D005710:Gallium Radioisotopes; D058185:Magnetite Nanoparticles; D019275:Radiopharmaceuticals