title: Inhaled ciprofloxacin for chronic airways infections caused by Pseudomonas aeruginosa.
abstract: Chronic infection of the airways with Pseudomonas aeruginosa represents a therapeutic challenge. Currently existing approaches are particularly based on systemic approaches and this increases the risk of strain resistance selection and is frequently associated with side effects. Therefore, local delivery of antibiotics may reduce these risks and may provide sustained sterilization of the respiratory tract. In fact, this approach was found to be effective with inhaled tobramycin in cystic fibrosis. Inhaled ciprofloxacin (dry powder inhaled formulation or liposomal inhaled formulation) is currently being investigated in chronic infections of the airways in cystic fibrosis, non-cystic fibrosis bronchiectasis and chronic obstructive pulmonary disease, and the initial clinical data are encouraging. This paper presents a perspective on the potential role of inhaled ciprofloxacin in such infections.
authors.affiliation: Department of Medicine II - Pulmonary Disease, University of Medicine & Pharmacy Gr.T. Popa Iasi, Pulmonary Disease University Hospital, 30 Dr I Cihac Str, 700115 Iasi, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro
authors.forename: Sabina
authors.initials: S
authors.lastname: Antonela Antoniu
mesh_terms: D000280:Administration, Inhalation; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D008081:Liposomes; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000472:pathogenicity; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D008081:Liposomes; D002939:Ciprofloxacin