title: The application of super paramagnetic iron oxide-labeled mesenchymal stem cells in cell-based therapy.
abstract: Mesenchymal stem cell (MSC)-based therapy has great potential for tissue regeneration. However, being able to monitor the in vivo behavior of implanted MSCs and understand the fate of these cells is necessary for further development of successful therapies and requires an effective, non-invasive and non-toxic technique for cell tracking. Super paramagnetic iron oxide (SPIO) is an idea label and tracer of MSCs. MRI can be used to follow SPIO-labeled MSCs and has been proposed as a gold standard for monitoring the in vivo biodistribution and migration of implanted SPIO-labeled MSCs. This review discusses the biological effects of SPIO labeling on MSCs and the therapeutic applications of local or systemic delivery of these labeled cells.
authors.affiliation: Department of Orthopaedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.
authors.forename: Yiying
authors.initials: Y
authors.lastname: Qi
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Huang
authors.forename: Weiqi
authors.initials: W
authors.lastname: Yan
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D058948:Cell Tracking / Q000379:methods; D064987:Cell- and Tissue-Based Therapy; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D013194:Staining and Labeling
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide