title: Does post-cardiac surgery magnesium supplementation improve outcome?
abstract: Hypomagnesemia has been linked with increased morbidity and mortality in critically ill patients. Since the condition is common after cardiopulmonary bypass surgery, the objective of this study was to determine whether magnesium supplementation in the immediate postoperative period may improve outcomes of patients undergoing cardiac surgery with cardiopulmonary bypass. This prospective, randomized, double-blind, placebo-controlled study was conducted in a third-level, cardiac surgery intensive care unit (ICU) at a university hospital. Two hundred and sixteen patients undergoing elective cardiac surgery with cardiopulmonary bypass were randomized to receive either an intravenous bolus of 1.5 g of magnesium sulphate followed by an infusion of 12 g of the same salt in 24 h (105 patients), or placebo (111 patients) administered according to the same schedule as the treatment group. No significant differences were found either in the primary end point (hours of intubation) or in the secondary end points (length of inotropic support, new atrial fibrillation, ventricular tachycardia or ventricular fibrillation, length of intensive care unit stay, or ICU or hospital mortality). Hypomagnesemia was present in 12% of patients on admission to the intensive care unit. The magnesium group had a greater need for pacemaker stimulation. In conclusion, under the conditions of the present study, magnesium supplementation after cardiac surgery with cardiopulmonary bypass does not favourably affect clinical outcomes.
authors.affiliation: Department of Critical Care, Hospital Universitari de Bellvitge, Barcelona, Spain. 27683lcc@comb.cat
authors.forename: Maria L
authors.initials: ML
authors.lastname: Carrió
authors.forename: Josep L
authors.initials: JL
authors.lastname: Ventura
authors.forename: Casimiro
authors.initials: C
authors.lastname: Javierre
authors.forename: David
authors.initials: D
authors.lastname: Rodríguez-Castro
authors.forename: Elisabet
authors.initials: E
authors.lastname: Farrero
authors.forename: Herminia
authors.initials: H
authors.lastname: Torrado
authors.forename: Maria B
authors.initials: MB
authors.lastname: Badia
authors.forename: Jorge
authors.initials: J
authors.lastname: Granados
mesh_terms: D000368:Aged; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D053565:Hypercalciuria / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D008278:Magnesium Sulfate / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D008875:Middle Aged; D009397:Nephrocalcinosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D011446:Prospective Studies; D015499:Renal Tubular Transport, Inborn Errors / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D008278:Magnesium Sulfate