title: Advances in nanotechnology for the management of coronary artery disease.
abstract: Nanotechnology holds tremendous potential to advance the current treatment of coronary artery disease. Nanotechnology may assist medical therapies by providing a safe and efficacious delivery platform for a variety of drugs aimed at modulating lipid disorders, decreasing inflammation and angiogenesis within atherosclerotic plaques, and preventing plaque thrombosis. Nanotechnology may improve coronary stent applications by promoting endothelial recovery on a stent surface utilizing bio-mimetic nanofibrous scaffolds, and also by preventing in-stent restenosis using nanoparticle-based delivery of drugs that are decoupled from stents. Additionally, nanotechnology may enhance tissue-engineered graft materials for application in coronary artery bypass grafting by facilitating cellular infiltration and remodeling of a graft matrix.
authors.affiliation: Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: June-Wha
authors.initials: JW
authors.lastname: Rhee
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Wu
mesh_terms: D001807:Blood Vessel Prosthesis; D003324:Coronary Artery Disease / Q000628:therapy*; D016503:Drug Delivery Systems; D006801:Humans; D036103:Nanotechnology / Q000379:methods*; D062645:Percutaneous Coronary Intervention / Q000379:methods; D015607:Stents