title: Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate.
abstract: Low-dose methotrexate (MTX) is part of the mainstay of rheumatoid arthritis treatment. Hepatotoxicity is among the most feared side effects of low-dose MTX and is associated with increased morbidity. At present, histological evaluation of liver biopsies is the gold standard to retrospectively diagnose MTX-induced liver damage. Genetic markers present an interesting opportunity to preemptively identify patients at risk for MTX-induced hepatotoxicity. Here, we will review the literature on candidate genetic markers for the risk of MTX-induced hepatotoxicity. These candidate genetic markers include polymorphisms in the gene encoding the enzyme MTHFR.
authors.affiliation: Department of Clinical Pharmacy, San Cecilio University Hospital Granada, Spain.
authors.forename: Cristina Lucía
authors.initials: CL
authors.lastname: Dávila-Fajardo
authors.forename: Jesse J
authors.initials: JJ
authors.lastname: Swen
authors.forename: José
authors.initials: J
authors.lastname: Cabeza Barrera
authors.forename: Henk-Jan
authors.initials: HJ
authors.lastname: Guchelaar
mesh_terms: D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000235:genetics*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000235:genetics*; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate