title: Tumor-infiltrating B cells and T cells: Working together to promote patient survival.
abstract: We recently reported a novel cooperative relationship between tumor-infiltrating B cells and CD8(+) T cells in ovarian cancer, leading to increased patient survival. Here, we discuss the mechanisms whereby B cells might enhance cellular immunity, including serving as antigen-presenting cells, organizing tertiary lymphoid structures and secreting polarizing cytokines. The enhancement of both B and T-cell responses may result in more potent and sustained antitumor immunity.
authors.affiliation: Trev and Joyce Deeley Research Centre; BC Cancer Agency; Victoria, BC Canada ; Department of Medical Genetics; University of British Columbia; Vancouver, BC Canada.
authors.forename: Julie S
authors.initials: JS
authors.lastname: Nielsen
authors.forename: Brad H
authors.initials: BH
authors.lastname: Nelson