title: Nontuberculous mycobacterial disease is not a contraindication to lung transplantation in patients with cystic fibrosis: a retrospective analysis in a Danish patient population.
abstract: Whether nontuberculous mycobacterial (NTM) disease is a contraindication to lung transplantation remains controversial. We conducted a nationwide study to evaluate the clinical importance of NTM infection among lung transplant patients with cystic fibrosis (CF) in Denmark and to determine if NTM infection poses a contraindication to lung transplantation. All CF patients with current or prior NTM who had undergone lung transplantation were identified. Out of 52 lung transplant patients with CF 9 (17%) had NTM disease. Five patients had known infection at the time of transplantation. Two of these died of non-NTM-related causes whereas two developed deep Mycobacterium abscessus wound infections and one was transiently culture negative until M abscessus was reactivated. One patient was subsequently cured; the other two remained on therapy with good performance status. The study supports the contention that CF patients with prior or active NTM can undergo lung transplantation although postoperative complications can be expected.
authors.affiliation: Copenhagen CF Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. tavs.qvist@gmail.com
authors.forename: T
authors.initials: T
authors.lastname: Qvist
authors.forename: T
authors.initials: T
authors.lastname: Pressler
authors.forename: V O
authors.initials: VO
authors.lastname: Thomsen
authors.forename: M
authors.initials: M
authors.lastname: Skov
authors.forename: M
authors.initials: M
authors.lastname: Iversen
authors.forename: T L
authors.initials: TL
authors.lastname: Katzenstein
mesh_terms: D000293:Adolescent; D000328:Adult; D001992:Bronchoalveolar Lavage Fluid; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications* / Q000628:therapy*; D003718:Denmark; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications* / Q000175:diagnosis*; D009170:Nontuberculous Mycobacteria; D012189:Retrospective Studies; D013183:Sputum / Q000378:metabolism; D013997:Time Factors; D016896:Treatment Outcome; D014946:Wound Infection; D055815:Young Adult