title: Molecular library synthesis using complex substrates: expanding the framework of triterpenoids.
abstract: The remodeling of a natural product core framework by means of diversity-oriented synthesis (DOS) is a valuable approach to access diverse/biologically relevant chemical space and to overcome the limitations of combinatorial-type compounds. Here we provide proof of principle and a thorough conformational analysis for a general strategy whereby the inherent complexity of a starting material is used to define the regio- and stereochemical outcomes of reactions in chemical library construction. This is in contrast to the traditional DOS logic employing reaction development and catalysis to drive library diversity.
authors.affiliation: Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
authors.forename: Vasily A
authors.initials: VA
authors.lastname: Ignatenko
authors.forename: Yong
authors.initials: Y
authors.lastname: Han
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Tochtrop
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000706:statistics & numerical data; D008968:Molecular Conformation; D054852:Small Molecule Libraries; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D054852:Small Molecule Libraries; D014315:Triterpenes