title: LRP5 and LRP6 in development and disease.
abstract: Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are highly homologous proteins with key functions in canonical Wnt signaling. Alterations in the genes encoding these receptors or their interacting proteins are linked to human diseases, and as such they have been a major focus of drug development efforts to treat several human conditions including osteoporosis, cancer, and metabolic disease. Here, we discuss the links between alterations in LRP5/6 and disease, proteins that interact with them, and insights gained into their function from mouse models. We also highlight current drug development related to LRP5/6 as well as how the recent elucidation of their crystal structures may allow further refinement of our ability to target them for therapeutic benefit.
authors.affiliation: Center for Skeletal Disease Research, Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
authors.forename: Danese M
authors.initials: DM
authors.lastname: Joiner
authors.forename: Jiyuan
authors.initials: J
authors.lastname: Ke
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Zhong
authors.forename: H Eric
authors.initials: HE
authors.lastname: Xu
authors.forename: Bart O
authors.initials: BO
authors.lastname: Williams
mesh_terms: D000818:Animals; D006801:Humans; D060492:Low Density Lipoprotein Receptor-Related Protein-5 / Q000737:chemistry* / Q000378:metabolism*; D060488:Low Density Lipoprotein Receptor-Related Protein-6 / Q000737:chemistry* / Q000378:metabolism*; D008954:Models, Biological; D060449:Wnt Signaling Pathway / Q000502:physiology
chemical_list: D060492:Low Density Lipoprotein Receptor-Related Protein-5; D060488:Low Density Lipoprotein Receptor-Related Protein-6