title: Family history of autoimmune disease in patients with Aicardi-Goutières syndrome.
abstract: OBJECTIVE
  The purpose of this study was to explore anecdotal evidence for an increase in the prevalence of autoimmune diseases in family members of patients with Aicardi-Goutières syndrome (AGS).
  
  
  METHODS
  Pedigrees of patients and controls were analyzed using chi-square and logistic regression to assess differences in reports of autoimmune disease among family members of cases and controls. Data was collected at Children's National Medical Center in Washington, DC, USA and at the International Aicardi-Goutières Syndrome Association Scientific Headquarters, C. Mondino National Institute of Neurology in Pavia, Italy.
  
  
  RESULTS
  The number of individuals with reported autoimmune disease is significantly related to having a family member with AGS (χ(2) = 6.25, P = 0.01); 10% (35/320) of relatives of patients with AGS had a reported autoimmune disease diagnosis compared to 5% (18/344) of relatives of controls. There was a greater percent of maternal relatives of patients with AGS reporting autoimmune disease (14.6%), compared to controls (6.8%), with the association being statistically significant. The association was not significant for paternal relatives.
  
  
  CONCLUSIONS
  The prevalence of autoimmune disease in relatives of children with AGS is significantly increased compared to controls. More research is needed to better understand this association.
authors.affiliation: Department of Neurology, Children's National Medical Center, Washington, DC 20010, USA.
authors.forename: Johanna L
authors.initials: JL
authors.lastname: Schmidt
authors.forename: Ivana
authors.initials: I
authors.lastname: Olivieri
authors.forename: Jodie M
authors.initials: JM
authors.lastname: Vento
authors.forename: Elisa
authors.initials: E
authors.lastname: Fazzi
authors.forename: Heather
authors.initials: H
authors.lastname: Gordish-Dressman
authors.forename: Simona
authors.initials: S
authors.lastname: Orcesi
authors.forename: Adeline
authors.initials: A
authors.lastname: Vanderver
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology*; D020274:Autoimmune Diseases of the Nervous System / Q000235:genetics* / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D009421:Nervous System Malformations / Q000235:genetics* / Q000276:immunology*; D015995:Prevalence