title: Phenylethanoid glycosides from the stems of Callicarpa peii (hemostatic drug).
abstract: Two new trisaccharide intermediates of phenylethanoid glycosides, peiioside A(1)/A(2) (1a/1b) and peiioside B (2), were isolated from the n-BuOH fraction of MeOH extract of the stems of Callicarpa peii H.T. Chang, together with five biogenetic relevant known compounds 3-7. The structures of compounds 1 and 2 were elucidated by extensive spectroscopic methods (especially 2D-NMR techniques) and acid-catalyzed hydrolysis as O-α-l-rhamnopyranosyl-(1″→3')-O-[β-d-apiofuranosyl-(1‴→6')] -4'-O-[(E)-caffeoyl]-d-glucopyranoside] (1a/1b), 3,4-dihydroxy-β-phenylethoxy-O-[β-d-apiofuranosyl-(1‴→6')-α-l-rhamnopyranosyl-(1″→3')-O-β-d-glucopyranoside] (2), respectively. On the basis of the isolated compounds, a presumable biogenetic pathway of the biologically interesting phenylethanoid glycosides about forsythoside B (3) and acteoside (4) isolated from this species was proposed. Isolation of five related intermediates (1-2, 5-7) provided further support for the biogenetic path. This is the first report about phytochemical research on C. peii and the biogenetic hypothesis of forsythoside B and acteoside.
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
authors.forename: Ai-Zhi
authors.initials: AZ
authors.lastname: Wu
authors.forename: Ya-Jing
authors.initials: YJ
authors.lastname: Zhai
authors.forename: Zhong-Xiang
authors.initials: ZX
authors.lastname: Zhao
authors.forename: Cui-Xian
authors.initials: CX
authors.lastname: Zhang
authors.forename: Chao-Zhan
authors.initials: CZ
authors.lastname: Lin
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Zhu
mesh_terms: D000818:Animals; D032408:Callicarpa / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D006490:Hemostatics / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure
chemical_list: D006027:Glycosides; D006490:Hemostatics; C582259:peiioside A; C582260:peiioside B