title: [Neuropharmacological potential of sigma1-receptors: new therapeutic possibilities].
abstract: Sigma1-receptors are an independent class of intracellular receptors which are implicated in the regulation of cell bioenergetics that suggest their involvement in different neuropsychiatric diseases. Sigma1-receptors regulate different ion channels, including calcium channels, NMDA-receptors, and are involved in the neurotransmitter release, neurogenesis and synaptogenesis. These receptors recognize with a different affinity a variety of ligands of different structural classes with different therapeutic applications. High affinity to sigma1-receptors may play an important role in the mechanism of action of some antidepressants, in particular fluvoxamine.
authors.forename: O V
authors.initials: OV
authors.lastname: Vorob'eva
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology; D016666:Fluvoxamine / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007858:Learning; D008024:Ligands; D019964:Mood Disorders / Q000503:physiopathology; D017480:Receptors, sigma / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D000097605:Sigma-1 Receptor
chemical_list: D000928:Antidepressive Agents; D016666:Fluvoxamine; D008024:Ligands; D017480:Receptors, sigma; D000097605:Sigma-1 Receptor