title: Hypertrophic olivary degeneration after gamma-knife radiosurgery for pontine metastasis.
abstract: We present a case of a 57-year-old woman who underwent gamma-knife radiosurgery (GKRS) for pontine metastasis. Magnetic resonance (MR) imaging 2.8 months after GKRS showed T₂ hyperintensity and hypertrophy of the left inferior olivary nucleus (ION) without gadolinium enhancement and smaller pontine metastasis. We diagnosed the signal change in the left ION as hypertrophic olivary degeneration (HOD) resulting from damage to the left central tegmental tract. We believe this is the first report to describe HOD after GKRS for pontine metastasis.
authors.affiliation: Division of Radiology, Department of Pathophysiological Therapeutic Science, Faculty of Medicine, Tottori University, Nishi-cho, Yonago, Japan. shino-y@olive.plala.or.jp
authors.forename: Yuki
authors.initials: Y
authors.lastname: Shinohara
authors.forename: Toshibumi
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Fumiko
authors.initials: F
authors.lastname: Kinoshita
authors.forename: Toshihide
authors.initials: T
authors.lastname: Ogawa
mesh_terms: D020295:Brain Stem Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006801:Humans; D006984:Hypertrophy; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009847:Olivary Nucleus / Q000473:pathology*; D016634:Radiosurgery / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D005682:Gadolinium