title: [A case of Fisher syndrome with multiple cranial neuropathy and abnormal EEG findings].
abstract: A 69-year-old woman was admitted because of unconsciousness and multiple cranial neuropathy. She had suffered diarrhea 2 weeks previously. On examination, she was noted to have total external and internal ophthalmoplegia, bilateral facial palsy, dysphagia, dysarthria, neck weakness, distal motor weakness of all limbs, and ataxia. She had also presented with hyporeflexia and hypoesthesia, but with a bilateral pyramidal tract sign. A study of her cerebrospinal fluid revealed albuminocytologic dissociation, and nerve conduction study revealed demyelination of her peripheral nerves. Moreover, electroencephalography findings were abnormal and anti-GQ1b antibody was positive. We diagnosed Fisher syndrome with Guillain-Barré syndrome and Bickerstaff brainstem encephalitis. We administered intravenous immunoglobulin treatment for 5 days and her symptoms gradually improved. However, her external ophthalmoplegia continued for several months.
authors.affiliation: Department of Geriatric Medicine, Medicine and Bioscience, Graduate School of Medicine, Ehime University.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ochi
authors.forename: Nako
authors.initials: N
authors.lastname: Shinohara
authors.forename: Kenji
authors.initials: K
authors.lastname: Kamogawa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Okada
authors.forename: Tokihisa
authors.initials: T
authors.lastname: Nagai
authors.forename: Keiko
authors.initials: K
authors.lastname: Taguchi
authors.forename: Rie
authors.initials: R
authors.lastname: Takita
authors.forename: Michiya
authors.initials: M
authors.lastname: Igase
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kohara
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
mesh_terms: D000368:Aged; D003389:Cranial Nerve Diseases / Q000150:complications*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D019846:Miller Fisher Syndrome / Q000150:complications* / Q000503:physiopathology*