title: Short communication: antibody responses to human immunodeficiency virus envelope from infections with multiple subtypes utilize the 1F7-idiotypic repertoire.
abstract: A common idiotype of anti-HIV antibodies (Abs), designated as 1F7, was recently observed on anti-HIV broadly neutralizing Abs (BnAbs). The presence of the 1F7-idiotype on BnAbs suggests that continuous selection of 1F7-idiotypic Abs may allow these clones to achieve the somatic hypermutation necessary for broad neutralization. As the selection of type-specific BnAbs occurs in the setting of infections with a wide array of HIV subtypes, we investigated Abs from subjects infected with diverse subtypes for the selection of 1F7-idiotypic Abs. We observed the 1F7-idiotype on antiviral Abs in infections with various HIV subtypes. Furthermore, gp140-specific 1F7-idiotypic Abs recognized the gp140 antigens from several HIV subtypes. These results demonstrate that the 1F7-idiotype is a common characteristic of Abs from infections with diverse HIV subtypes, and suggests that early cross-reactivity of 1F7-idiotypic clones may act in conjunction with somatic hypermutation to produce BnAbs.
authors.affiliation: Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Parsons
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Center
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Routy
authors.forename: Danielle
authors.initials: D
authors.lastname: Rouleau
authors.forename: Roger
authors.initials: R
authors.lastname: Leblanc
authors.forename: Mark A
authors.initials: MA
authors.lastname: Wainberg
authors.forename: Cécile L
authors.initials: CL
authors.lastname: Tremblay
authors.forename: Marcel D
authors.initials: MD
authors.lastname: Zannou
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Kent
authors.forename: Michael D
authors.initials: MD
authors.lastname: Grant
authors.forename: Nicole F
authors.initials: NF
authors.lastname: Bernard
mesh_terms: D000917:Antibody Formation / Q000276:immunology*; D015483:HIV Antibodies / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology
chemical_list: D015483:HIV Antibodies; D007130:Immunoglobulin Idiotypes; D014759:Viral Envelope Proteins