title: NO inhibitory guaianolide-derived terpenoids from Artemisia argyi.
abstract: An unusual dimeric guaianolide, artemilinin A (1) and a sesquiterpene-monoterpene lactone, isoartemisolide (2), were isolated from the leaves of Artemisia argyi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR), and the absolute configurations were determined by CD spectra and quantum chemical ECD calculation. Furthermore, in in vitro assay, compound 2 exhibited pronounced inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC50 value of 4.00μM.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.forename: Ke-wu
authors.initials: KW
authors.lastname: Zeng
authors.forename: Jing-rong
authors.initials: JR
authors.lastname: Cui
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Peng-fei
authors.initials: PF
authors.lastname: Tu
mesh_terms: D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D002460:Cell Line; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D018515:Plant Leaves / Q000737:chemistry; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D007783:Lactones; D054830:Sesterterpenes; C583381:isoartemisolide; D009569:Nitric Oxide