title: Towards a clinical use of miRNAs in pancreatic cancer biopsies.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, despite advances in imaging, surgery and a greater understanding of its molecular biology. Patient outcomes remain poor due to an inability to detect disease early and resistance to anticancer treatments. miRNAs are promised to become ideal cancer biomarkers, as they are tumor and tissue specific and also incredibly stable molecules. So far, large profiling studies of the PDAC miRNome have identified the 'usual suspects' known to be deregulated in solid tumors, such as oncomiR-21, as well as others that could be more robust for differentiating malignant from benign pancreatic disease. However, many of these are yet to be validated clinically. The paper under evaluation provides further evidence for the use of miRNAs as diagnostic biomarkers for PDAC. We have reviewed the use of miRNAs as diagnostic analytes for detecting PDAC in biopsies.
authors.affiliation: HPB Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK. a.frampton@imperial.ac.uk
authors.forename: Adam E
authors.initials: AE
authors.lastname: Frampton
authors.forename: Tamara M H
authors.initials: TM
authors.lastname: Gall
authors.forename: Leandro
authors.initials: L
authors.lastname: Castellano
authors.forename: Justin
authors.initials: J
authors.lastname: Stebbing
authors.forename: Long R
authors.initials: LR
authors.lastname: Jiao
authors.forename: Jonathan
authors.initials: J
authors.lastname: Krell