title: Antinociceptive effects of A1 and A2 type botulinum toxins on carrageenan-induced hyperalgesia in rat.
abstract: We performed a study on the antinociceptive effects of A1 and A2 type (A1LL and A2NTX, respectively) botulinum toxin on carrageenan-induced hyperalgesia in the rat. Both A1LL and A2NTX had antinociceptive effects in the carrageenan-induced inflammatory pain model, reducing the mechanical and thermal hyperalgesia. A2NTX also reduced the increase in c-fos immunoreactivity in L4-L5 spinal segments induced by carrageenan, suggesting that A2NTX inhibits the activation of spinal nociceptive afferent fibers that project to the CNS. Our results indicate that A2NTX may offer a new therapeutic tool to treat inflammatory pain.
authors.affiliation: Research Division for Life Sciences, Kumamoto Health Science University, Izumimachi 325, Kumamoto 861-5598, Japan.
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Shin
authors.forename: Takashi
authors.initials: T
authors.lastname: Yukihira
authors.forename: Yushi
authors.initials: Y
authors.lastname: Ito
authors.forename: Norio
authors.initials: N
authors.lastname: Akaike
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects / Q000503:physiopathology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D019274:Botulinum Toxins, Type A / Q000494:pharmacology*; D002351:Carrageenan; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D006358:Hot Temperature; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D007279:Injections, Subcutaneous; D008297:Male; D009465:Neuromuscular Agents / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D010147:Pain Measurement; D010812:Physical Stimulation; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013127:Spinal Nerves / Q000187:drug effects / Q000503:physiopathology
chemical_list: D000700:Analgesics; D009465:Neuromuscular Agents; D016760:Proto-Oncogene Proteins c-fos; D002351:Carrageenan; D019274:Botulinum Toxins, Type A