title: A case of slowly progressive type 1 diabetes with insulin independence maintained for 10 years with α-glucosidase inhibitor monotherapy.
abstract: Slowly Progressive Type 1 Diabetes (SPT1D) is characterized by the absence of insulin dependence at the onset of diabetes and persistent detection of islet cell autoantibodies. These patients with high titers of glutamic acid decarboxylase autoantibodies (GADA) are known to progress to insulin dependence within several years. Low-dose insulin injections have been reported to prevent or delay the decline of insulin secretion in SPT1D patients. We experienced the case of an SPT1D patient with preserved endogenous insulin secretion and good glycemic control achieved with α-glucosidase inhibitor (α-GI) treatment alone for 10 years despite having continuously elevated GADA titers. The details of this case suggest that α-GI treatment might have preventive effects on SPT1D progression.
authors.affiliation: Department of Diabetes and Metabolism, Tohoku University Hospital, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Munakata
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamada
authors.forename: Kazuma
authors.initials: K
authors.lastname: Takahashi
authors.forename: Sohei
authors.initials: S
authors.lastname: Tsukita
authors.forename: Kei
authors.initials: K
authors.lastname: Takahashi
authors.forename: Shojiro
authors.initials: S
authors.lastname: Sawada
authors.forename: Junta
authors.initials: J
authors.lastname: Imai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ishigaki
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Oka
authors.forename: Hideki
authors.initials: H
authors.lastname: Katagiri
mesh_terms: D020909:Acarbose / Q000627:therapeutic use*; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D018450:Disease Progression; D005260:Female; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D020909:Acarbose