title: Effects of propofol on left ventricular mechanoenergetics in the excised cross-circulated canine heart.
abstract: Although propofol is commonly used for general anesthesia, its direct effects on left ventricular (LV) contractility and energetics remain unknown. Accordingly, we studied the effects of intracoronary propofol on excised cross-circulated canine hearts using the framework of the Emax (a contractility index)-PVA (systolic pressure-volume area, a measure of total mechanical energy)-V(O2) (myocardial oxygen consumption per beat) relationship. We obtained 1) the V(O2)-PVA relationship of isovolumic contractions with varied LV volumes at a constant Emax, 2) the V(O2)-PVA relationship with varied LV volumes at a constant intracoronary concentration of propofol, and 3) the V(O2)-PVA relationship under increased intracoronary concentrations of either propofol or CaCl(2) at a constant LV volume to assess the cardiac mechanoenergetic effects of propofol. We found that propofol decreased Emax dose-dependently. The slope of the linear V(O2)-PVA relationship (oxygen cost of PVA) remained unchanged by propofol. The PVA-independent V(O2)-Emax relationship (oxygen cost of Emax) was the same for propofol and Ca(2+). In conclusion, propofol showed a direct negative inotropic effect on LV. At its clinical concentrations, decreases in contractility by propofol were relatively small. Propofol shows mechanoenergetic effects on the LV that are similar to those of Ca(2+) blockers or ß-antagonists-i.e., it exerts negative inotropic effects without changing the oxygen costs of Emax and PVA.
authors.affiliation: Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Waso
authors.initials: W
authors.lastname: Fujinaka
authors.forename: Juichiro
authors.initials: J
authors.lastname: Shimizu
authors.forename: Gentaro
authors.initials: G
authors.lastname: Iribe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imaoka
authors.forename: Yu
authors.initials: Y
authors.lastname: Oshima
authors.forename: Takahiko
authors.initials: T
authors.lastname: Kiyooka
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Morita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mohri
mesh_terms: D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D003427:Cross Circulation; D004285:Dogs; D004734:Energy Metabolism / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D015742:Propofol / Q000494:pharmacology*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol