title: Strategies for expanding the UK pool of potential intestinal transplant donors.
abstract: BACKGROUND
  The pool of suitable donors and listed recipients for intestinal transplantation is small, resulting in difficulties in donor-to-recipient matching and significant mortality on the waiting list. This study aims to help define the pool of potential donors for intestinal transplantation and propose methods for an increased utilization of donor bowels in the United Kingdom.
  
  
  METHODS
  Data on bowel offering from 657 donors after brain stem death (DBD) and on 46 patients on the active intestinal transplant list over 12 months from 14 April 2011 were obtained from the UK Transplant Registry.
  
  
  RESULTS
  Family consent for bowel donation was lower than for the other transplantable organs. Only 57% of bowels from DBD donors with consent and meeting the bowel offering criteria were offered for transplantation. A lack of suitable recipients was the most common reason cited for not offering. Only 10% of offered bowels were accepted and transplanted by centers. Donor size discrepancy and human leukocyte antigen incompatibility were common reasons for declining offers of the bowel. There was a scarcity of young and small donors compared with the number of young and small patients requiring a transplant. Two patients who were on the active list during the time period died.
  
  
  CONCLUSIONS
  An increased awareness of bowel donation is needed to improve the low offering rate of bowels from DBD donors. A more robust UK bowel allocation system and a formalized European-wide intestinal donor organ sharing program should lead to an increased utilization of available donor bowels and a lower waiting list mortality rate.
authors.affiliation: Statistics and Clinical Audit, NHS Blood and Transplant, Bristol, UK.
authors.forename: Sally N
authors.initials: SN
authors.lastname: Rushton
authors.forename: Alex J
authors.initials: AJ
authors.lastname: Hudson
authors.forename: Dave
authors.initials: D
authors.lastname: Collett
authors.forename: James M
authors.initials: JM
authors.lastname: Neuberger
authors.forename: Darius F
authors.initials: DF
authors.lastname: Mirza
mesh_terms: D000017:ABO Blood-Group System; D000368:Aged; D015992:Body Mass Index; D006801:Humans; D007422:Intestines / Q000637:transplantation*; D008875:Middle Aged; D014019:Tissue Donors; D006113:United Kingdom
chemical_list: D000017:ABO Blood-Group System