title: The effects of cranberry juice on serum glucose, apoB, apoA-I, Lp(a), and Paraoxonase-1 activity in type 2 diabetic male patients.
abstract: BACKGROUND
  Type 2 diabetic patients are faced with a higher risk of dyslipidemia and cardiovascular disorders. This study was undertaken to assess the effect of consumption of 1 cup cranberry juice by type 2 diabetic patients on serum paraoxonase-1 (PON-1) activity, apoA-1, apoB, glucose, and Lp(a).
  
  
  METHODS
  In a double-blind randomized clinical trial, 58 type 2 diabetic male patients were randomly divided to receive 1 cup cranberry juice (CJ) or placebo drink daily for 12 weeks. Fasting blood were obtained at beginning and at the end of study (12(th) week). Serum glucose and PON-1 activity were measured by enzymatic and colorimetric methods, respectively. ApoB, apoA-I, and Lp(a) were determined immunoturbidimetrically. The data were analyzed by SPSS version 16.
  
  
  RESULTS
  There were significant decrease in serum glucose and apoB (P>0.05 and P>0.01, respectively) and significant increase in serum apoA-1 and PON-1 activity (P>0.05 and P<0.01, respectively) at the end of study in CJ group compared with control group. In CJ group at the end of study, there were significant decrease in serum glucose and apoB (P<0.01 and P<0.01, respectively) and significant increase in serum apo A-1 and PON-1 activity (P<0.01 and P<0.01, respectively) compared with initial values. In CJ group, there was no significant change in Lp(a) at the end of study compared with initial values and also compared with control group.
  
  
  CONCLUSIONS
  1 cup CJ for 12 weeks is effective in reducing serum glucose and apoB and increasing apoA-1 and PON-1 activity, so may have favorite effects on reducing CVD risk factors in type 2 diabetic male patients.
authors.affiliation: Department of nutrition, School of Health, Tehran University of Medical Sciences, Iran.
authors.forename: Farzad
authors.initials: F
authors.lastname: Shidfar
authors.forename: Iraj
authors.initials: I
authors.lastname: Heydari
authors.forename: Seyed Javed
authors.initials: SJ
authors.lastname: Hajimiresmaiel
authors.forename: Sharieh
authors.initials: S
authors.lastname: Hosseini
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Shidfar
authors.forename: Fariba
authors.initials: F
authors.lastname: Amiri