title: Worsening left ventricular apical peak strain early after right ventricular pacing.
abstract: We aimed to determine the effect of short-term right ventricle pacing (RV) on left ventricle (LV) mechanics using speckle tracking analysis. Conventional echocardiography and two-dimensional strain imaging was studied in 38 patients, mean age 81.6 ± 7.0, that had undergone pacemaker placement and were greater than 90% ventricularly paced. Mean duration of 24 months of RV pacing resulted in a significant decline in: LV apical diastolic rotational velocities (-59.0 ± -38.9 °/s to -28.0 ± -11.5 °/s, p 0.02), peak strain in the LV apical septal wall (-15.6 ± 8.5 to -13.5 ± 7.6, p 0.02), peak strain in LV apical lateral wall (-13.4 ± 8.9 to -11.4 ± 7.3, p 0.02). Thus, with only 24 months of RV pacing, there was a significant decline in peak strain of the LV apex and in apical diastolic rotational velocity that could account for eventual decline in left ventricular function.
authors.affiliation: Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259-5499, USA.
authors.forename: Nishath
authors.initials: N
authors.lastname: Quader
authors.forename: Uzma
authors.initials: U
authors.lastname: Jalal
authors.forename: Serag
authors.initials: S
authors.lastname: Raslan
authors.forename: Komandoor
authors.initials: K
authors.lastname: Srivathsan
authors.forename: Susan
authors.initials: S
authors.lastname: Wilansky
authors.forename: Samuel
authors.initials: S
authors.lastname: Unzek
authors.forename: Krishnaswamy
authors.initials: K
authors.lastname: Chandrasekran
authors.forename: Farouk
authors.initials: F
authors.lastname: Mookadam
mesh_terms: D000369:Aged, 80 and over; D002304:Cardiac Pacing, Artificial / Q000009:adverse effects*; D004452:Echocardiography / Q000379:methods*; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000517:prevention & control*