title: First evidence for functional vomeronasal 2 receptor genes in primates.
abstract: Two classes of vomeronasal receptor genes, V1R and V2R, occur in vertebrates. Whereas, V1R loci are found in a wide variety of mammals, including primates, intact V2R genes have thus far only been described in rodents and marsupials. In primates, the V2R repertoire has been considered degenerate. Here, we identify for the first time two intact V2R loci in a strepsirrhine primate, the grey mouse lemur (Microcebus murinus), and demonstrate their expression in the vomeronasal organ. Putatively functional orthologues are present in two other strepsirrhines, whereas, both loci are pseudogenes in a range of anthropoid species. The functional significance of the loci is unknown, but positive selection on one of them is consistent with an adaptive role in pheromone detection. Finally, conservation of V2R loci in strepsirrhines is notable, given their high diversity and role in MUP and MHC detection in rodents.
authors.affiliation: Institute of Zoology, University of Veterinary Medicine, Hanover, Germany. philipp.hohenbrink@tiho-hannover.de
authors.forename: Philipp
authors.initials: P
authors.lastname: Hohenbrink
authors.forename: Nicholas I
authors.initials: NI
authors.lastname: Mundy
authors.forename: Elke
authors.initials: E
authors.lastname: Zimmermann
authors.forename: Ute
authors.initials: U
authors.lastname: Radespiel
mesh_terms: D000818:Animals; D016565:Cheirogaleidae / Q000235:genetics / Q000378:metabolism; D018076:DNA, Complementary / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011323:Primates / Q000235:genetics* / Q000378:metabolism*; D012313:RNA / Q000235:genetics; D043563:Receptors, Pheromone / Q000235:genetics* / Q000378:metabolism*; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D019147:Vomeronasal Organ / Q000378:metabolism
chemical_list: D018076:DNA, Complementary; D043563:Receptors, Pheromone; D012313:RNA