title: Will SNPs be useful predictors of normal tissue radiosensitivity in the future?
abstract: The ability to predict individual risk of radiation-induced normal tissue complications is a long sought goal in radiobiology. The last decade saw increasing interest in identifying associations between single nucleotide polymorphisms (SNPs) and normal tissue complication risk. Nevertheless, it remains controversial whether SNPs will be useful predictors of normal tissue radiosensitivity. This paper provides a summary of a scientific debate held at the 31st ESTRO conference in which four scientists argued in favor or against the motion that SNPs will be useful predictors of normal tissue radiosensitivity in the future.
authors.affiliation: Aarhus University Hospital, Denmark. nicolaj@oncology.dk
authors.forename: Christian Nicolaj
authors.initials: CN
authors.lastname: Andreassen
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Dikomey
authors.forename: Matthew
authors.initials: M
authors.lastname: Parliament
authors.forename: Catharine Mary Louise
authors.initials: CM
authors.lastname: West
mesh_terms: D002470:Cell Survival / Q000235:genetics; D003226:Congresses as Topic; D004268:DNA-Binding Proteins / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D015201:Meta-Analysis as Topic; D010597:Pharmacogenetics / Q000639:trends; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D011836:Radiation Tolerance / Q000235:genetics*; D011853:Radiobiology / Q000639:trends; D012306:Risk; D012680:Sensitivity and Specificity
chemical_list: D004268:DNA-Binding Proteins; D005819:Genetic Markers