title: Efficacy and safety of the ketogenic diet in Chinese children.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of the ketogenic diet (KD) treatment of refractory childhood epilepsy in China and determine which children are more likely to respond.
  
  
  METHODS
  Between 2004 and 2011, we prospectively enrolled 317 children with refractory epilepsy for the KD treatment in Shenzhen Children's Hospital and followed up for at least a year. Outcome was measured by seizure frequencies before and after the diet, change in anticonvulsant use and adverse effects. We also evaluated influences of different variables (starting age, duration of epilepsy and underlying conditions) on the outcome.
  
  
  RESULTS
  Intent-to-treat analysis showed that after 3, 6 and 12 months, 62.8%, 42.0% and 24.3% remained on the diet, 35.0%, 26.2% and 18.6% showed >50% seizure reduction, including 20.8%, 13.6% and 10.7% seizure free, respectively. Starting age may influence efficacy. The ≥10 age group showed worse response than the <10 age group, though the difference was statistically significant (p=0.039) at 3 month only. Other variables such as duration of epilepsy at the start of the diet, seizure types and aetiologies showed no significant influence on efficacy. Frequently reported complications included GI disturbance, food refusal and hypoproteinaemia.
  
  
  CONCLUSIONS
  The KD is a safe and efficacious therapy for intractable childhood epilepsy in Chinese children. The influence of age on efficacy is worth further investigation.
authors.affiliation: Department of Paediatric Neurology, Shenzhen Children's Hospital, Shenzhen, China.
authors.forename: Chenqu
authors.initials: C
authors.lastname: Suo
authors.forename: Jianxiang
authors.initials: J
authors.lastname: Liao
authors.forename: Xinguo
authors.initials: X
authors.lastname: Lu
authors.forename: Kewei
authors.initials: K
authors.lastname: Fang
authors.forename: Yan
authors.initials: Y
authors.lastname: Hu
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Dezhi
authors.initials: D
authors.lastname: Cao
authors.forename: Tieshuan
authors.initials: T
authors.lastname: Huang
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.forename: Chengrong
authors.initials: C
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D002681:China; D003131:Combined Modality Therapy / Q000009:adverse effects; D055423:Diet, Ketogenic / Q000009:adverse effects*; D004827:Epilepsy / Q000178:diet therapy* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D019233:Retreatment; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants