title: Targeting the Wnt/frizzled signaling pathway after myocardial infarction: a new tool in the therapeutic toolbox?
abstract: Wnt/frizzled signaling in the adult heart is quiescent under normal conditions; however it is reactivated after myocardial infarction (MI). Any intervention at the various levels of this pathway can modulate its signaling. Several studies have targeted Wnt/frizzled signaling after MI with the majority of them indicating that the inhibition of the pathway is beneficial since it improves infarct healing and prevents heart failure. This suggests that blocking the Wnt/frizzled signaling pathway could be a potential novel therapeutic target to prevent the adverse cardiac remodeling after MI.
authors.affiliation: Department of Pharmacology, Cardiovascular Research Institute Maastricht, Maastricht University, 50 Universiteitssingel, 6229ER Maastricht, P.O. Box 616, 6200MD Maastricht, The Netherlands.
authors.forename: Evangelos P
authors.initials: EP
authors.lastname: Daskalopoulos
authors.forename: Kevin C M
authors.initials: KC
authors.lastname: Hermans
authors.forename: Ben J A
authors.initials: BJ
authors.lastname: Janssen
authors.forename: W
authors.initials: W
authors.lastname: Matthijs Blankesteijn
mesh_terms: D000328:Adult; D000818:Animals; D055808:Drug Discovery / Q000639:trends; D051157:Frizzled Receptors / Q000378:metabolism; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D058990:Molecular Targeted Therapy / Q000639:trends*; D009203:Myocardial Infarction / Q000150:complications / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D020257:Ventricular Remodeling / Q000187:drug effects*; D051153:Wnt Proteins / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000187:drug effects*
chemical_list: D051157:Frizzled Receptors; D051153:Wnt Proteins