title: A new protocol to determine the solubility of drugs into polymer matrixes.
abstract: In this paper we present a new protocol to determine faster the solubility of drugs into polymer matrixes. The originality of the method lies in the fact that the equilibrium saturated states are reached by demixing of supersaturated amorphous solid solutions and not by dissolution of crystalline drug into the amorphous polymer matrix as for usual methods. The equilibrium saturated states are thus much faster to reach due to the extra molecular mobility resulting from the strong plasticizing effect associated with the supersaturation conditions. The method is validated using the indomethacin/polyvinylpyrrolidone mixture whose solubility diagram was previously determined by usual techniques. The supersaturated states have been directly obtained in the solid state by comilling, and the investigations have been performed by differential scanning calorimetry and powder X-ray diffraction.
authors.affiliation: Université de Lille Nord de France, F-59000 Lille, USTL UMET (Unité Matériaux et Transformations), UMR CNRS 8207, F-59650 Villeneuve d'Ascq, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Mahieu
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Willart
authors.forename: Emeline
authors.initials: E
authors.lastname: Dudognon
authors.forename: Florence
authors.initials: F
authors.lastname: Danède
authors.forename: Marc
authors.initials: M
authors.lastname: Descamps
mesh_terms: D002151:Calorimetry; D007213:Indomethacin / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D014961:X-Ray Diffraction
chemical_list: D011108:Polymers; D011205:Povidone; D007213:Indomethacin