title: Plasma Endothelial Microparticles, TNF-a and IL-6 in Kawasaki Disease.
abstract: We studied the levels of endothelial microparticles (EMPs), IL-6, and TNF-a in patients with Kawasaki disease (KD). EMPs were enumerated by flow cytometry, while IL-6 and TNF-a were measured using enzyme-linked immunosorbent assay. EMPs and IL-6 were elevated in KD, the level of TNF-a in KD was not different from disease controls, but higher than healthy controls. EMPs were positively correlated with TNF-a and negatively correlated with albumin. Elevated level of EMPs, a biomarker of endothelial cells damage, concomitant with increased levels of TNF-a and IL-6, is seen in patients with KD.
authors.affiliation: Department of Pediatrics, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, China, 200092.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Tan
authors.forename: Yan
authors.initials: Y
authors.lastname: Yuan
authors.forename: Sun
authors.initials: S
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.forename: Tong-Xin
authors.initials: TX
authors.lastname: Chen
mesh_terms: D016022:Case-Control Studies; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D002675:Child, Preschool; D042783:Endothelial Cells / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000097:blood*; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000453:epidemiology / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha