title: Association of the variant rs2243421 of human DOC-2/DAB2 interactive protein gene (hDAB2IP) with gastric cancer in the Chinese Han population.
abstract: Human DOC-2/DAB2 interactive protein (hDAB2IP) gene is a novel member of the Ras GTPase-activating family and has been demonstrated to be a tumor-suppressor gene that inhibits cell survival and proliferation and induces cell apoptosis. It was reported that the expression level of hDAB2IP in gastric cancer tissue was highly correlated with tumor progression, however, whether hDAB2IP genetic variants are associated with the risk of gastric cancer remains yet unknown. In this case-control study, we conducted a genetic analysis for hDAB2IP variants in 311 patients with gastric cancer and 425 controls from the Chinese Han population. We found that the SNP rs2243421 of hDAB2IP gene with the minor allele C significantly revealed strong association with decreased gastric cancer susceptibility (P=0.007, adjusted odds ratio [OR]=0.734, 95%CI=0.586-0.919). Haplotypes rs2243421 and rs10985332 (HaploType: CC, P=0.012, aOR=0.760) and haplotypes rs2243421 and rs555996 (HaploType: CG, P=0.034, aOR=0.788) represented the decreased risk of gastric cancer, respectively. On the contrary, rs2243421 and rs555996 showed an elevated susceptibility (HaploType: TG, P=0.010, aOR=1.320). Our results for the first time provided new insight into susceptibility factors of hDAB2IP gene variants in carcinogenesis of gastric cancer.
authors.affiliation: Department of Biology, Anhui Medical University, Hefei 230032, China.
authors.forename: Song
authors.initials: S
authors.lastname: Xu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Du
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Fu-Sheng
authors.initials: FS
authors.lastname: Zhou
authors.forename: Marion
authors.initials: M
authors.lastname: Schneider
authors.forename: Xue-Ling
authors.initials: XL
authors.lastname: Ma
authors.forename: Hong-Yuan
authors.initials: HY
authors.lastname: Xu
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics*; D055815:Young Adult; D020703:ras GTPase-Activating Proteins / Q000235:genetics*
chemical_list: D002135:Calcium-Binding Proteins; C462952:DAB2IP protein, human; C091524:DOC2A protein, human; D009419:Nerve Tissue Proteins; D020703:ras GTPase-Activating Proteins