title: Alleviation of doxorubicin-induced nephrotoxicity and hepatotoxicity by chrysin in Wistar rats.
abstract: Abstract Objective: Doxorubicin (DXR) is an anticancer drug used in the treatment of many human malignancies. However, its clinical use is limited because of several side effects like cardiotoxicity, nephrotoxicity and hepatotoxicity. In the present study, we investigated the protective efficacy of chrysin against DXR-induced oxidative stress, nephro- and hepatotoxicity in male Wistar rats using biochemical and histopathological approaches.
  
  
  METHODS
  Wistar rats were subjected to concomitant pre- and post-phylactic oral treatment of chrysin (40 and 80 mg/kg b.wt.) against nephro- and hepatotoxicity induced by single i.p. injection of DXR (40 mg/kg b.wt). Nephrotoxicity and hepatotoxicity were assessed by measuring the level of serum creatinine, BUN, AST, ALT and LDH. The level of antioxidant armory of kidney and liver tissue was also measured.
  
  
  RESULTS
  Treatment with chrysin significantly decreased the levels of serum toxicity markers and additionally elevated antioxidant defense enzyme levels. Histopathological changes further confirmed the biochemical results showing that DXR caused significant structural damage to kidney and liver tissue architecture which were reversed with chrysin.
  
  
  CONCLUSIONS
  The results suggest that chrysin attenuated nephro and hepatic damage induced by DXR.
authors.affiliation: Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, India.
authors.forename: Summya
authors.initials: S
authors.lastname: Rashid
authors.forename: Nemat
authors.initials: N
authors.lastname: Ali
authors.forename: Sana
authors.initials: S
authors.lastname: Nafees
authors.forename: Shiekh Tanveer
authors.initials: ST
authors.lastname: Ahmad
authors.forename: Wani
authors.initials: W
authors.lastname: Arjumand
authors.forename: Syed Kazim
authors.initials: SK
authors.lastname: Hasan
authors.forename: Sarwat
authors.initials: S
authors.lastname: Sultana
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D004317:Doxorubicin / Q000633:toxicity*; D005419:Flavonoids / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017208:Rats, Wistar
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; C043561:chrysin; D008315:Malondialdehyde; D004317:Doxorubicin