title: Full-length transcriptome-based H-InvDB throws a new light on chromosome-centric proteomics.
abstract: H-Invitational Database (H-InvDB;  http://hinv.jp/ ) is an integrated database of all human genes and transcripts that started in an international collaborative research project for establishing a functional annotation database of human full-length cDNAs. Because H-InvDB contains an abundance of information for human transcripts, including not only well-characterized protein-coding transcripts but also those without experimental evidence at the protein level, this will be a useful information resource for identifying novel and uncharacterized human proteins (so-called missing proteins). By extending predicted protein data in H-InvDB, we developed the H-Inv Extended Protein Database (H-EPD;  http://hinv.jp/hinv/h-epd/ ). From now on, we plan to carry out a database-driven proteome research that makes full use of H-EPD to promote discoveries in the current and future C-HPP. Furthermore, we will push forward with the integration of genome, transcriptome, and proteome databases using a unique tool for connecting distributed databases and would like to develop a knowledge discovery system by incorporating data mining tools.
authors.affiliation: Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan. t.imanishi@aist.go.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Imanishi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nagai
authors.forename: Takuya
authors.initials: T
authors.lastname: Habara
authors.forename: Chisato
authors.initials: C
authors.lastname: Yamasaki
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Takeda
authors.forename: Sayaka
authors.initials: S
authors.lastname: Mikami
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Bando
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Tojo
authors.forename: Toshihide
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D018076:DNA, Complementary / Q000235:genetics / Q000378:metabolism; D016208:Databases, Factual; D015870:Gene Expression; D020869:Gene Expression Profiling; D015894:Genome, Human; D016045:Human Genome Project; D006801:Humans; D013058:Mass Spectrometry; D011506:Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism; D020543:Proteome
chemical_list: D018076:DNA, Complementary; D011506:Proteins; D020543:Proteome