title: Lipase inhibitory and LDL anti-oxidative triterpenes from Abies sibirica.
abstract: A methanol extract of Abies sibirica Ladeb, a Mongolian medicinal plant, had an inhibitory effect on both lipase activity in mouse plasma and LDL anti-oxidative activity, which are preventative factors for arteriosclerosis. The extract was fractionated by silica gel column chromatography and its active constituents were sought. From lipid soluble fractions, 20 terpenoids including seven hitherto unknown triterpenes were isolated. The latter triterpenes had either a γ-lactone ring with a lactol or a derivative thereof. Their chemical structures were determined by spectroscopic methods. The lipase inhibitory activity and LDL anti-oxidative activity of these compounds were evaluated. Some constituents (either lipase inhibitory or LDL anti-oxidative activities) had moderate inhibitory activities.
authors.affiliation: Department of Pharmacognosy, Tohoku Pharmaceutical University, Aoba-ku, Sendai, Japan.
authors.forename: Mizuho
authors.initials: M
authors.lastname: Handa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Murata
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Erdenechimeg
authors.initials: E
authors.lastname: Selenge
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyase
authors.forename: Javzan
authors.initials: J
authors.lastname: Batkhuu
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshizaki
mesh_terms: D028202:Abies / Q000737:chemistry*; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D008049:Lipase / Q000378:metabolism*; D051379:Mice; D028201:Pinaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D014315:Triterpenes; D008049:Lipase