title: [Non-CPAP therapies in obstructive sleep apnoea: an overview].
abstract: Optimal treatment of the obstructive sleep apnoea syndrome (OSAS) requires an individually designed and interdisciplinary approach. Continuous positive airway pressure (CPAP) is accepted as the first line therapy for patients with OSAS. However, non-CPAP therapies may be indicated as supportive therapeutical approach in CPAP failure or as an alternative approach in CPAP intolerance. Overall, the level of evidence for the majority of non-CPAP therapies is low. Mandibular advancement devices as a medical non-CPAP treatment have proven to reduce respiratory disturbances to a level which may be sufficient in mild to moderate sleep apnoea. Apnoea triggered neurostimulation of upper airway muscles is an innovative approach that has shown promising results in preclinical studies. Surgical treatment has previously been performed as single level surgery of the nasal, the oropharyngeal or hypopharyngeal level. However, only tonsillectomy in the presence of tonsillar hypertrophy and maxillomandibular advancement are recommended in carefully selected cases. Due to low success rates for single level surgery, multilevel surgery has been proposed as the surgical approach for the future.
authors.affiliation: Heinrich-Heine Universität Düsseldorf, Medizinische Fakultät, Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum Düsseldorf.
authors.forename: S
authors.initials: S
authors.lastname: Keymel
authors.forename: M
authors.initials: M
authors.lastname: Kelm
authors.forename: W J
authors.initials: WJ
authors.lastname: Randerath
mesh_terms: D045422:Continuous Positive Airway Pressure; D004599:Electric Stimulation Therapy / Q000379:methods*; D006801:Humans; D019186:Mandibular Advancement / Q000379:methods*; D020181:Sleep Apnea, Obstructive / Q000628:therapy*; D014068:Tonsillectomy / Q000379:methods*; D016896:Treatment Outcome