title: Diastereoselective intramolecular carbamoylketene/alkene [2 + 2] cycloaddition: enantioselective access to pyrrolidinoindoline alkaloids.
abstract: A novel and highly diastereoselective intramolecular carbamoylketene/alkene [2 + 2] cycloaddition has been developed, and the methodology was successfully applied to the enantioselective syntheses of (-)-esermethole and Takayama's intermediate for (+)-psychotrimine.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Araki
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Ozawa
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yokoe
authors.forename: Makoto
authors.initials: M
authors.lastname: Kanematsu
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Kozo
authors.initials: K
authors.lastname: Shishido
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010830:Physostigmine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D026121:Indole Alkaloids; D011758:Pyrroles; C518152:esermethole; C503380:psychotrimine; D010830:Physostigmine