title: Polymorphism of ACE gene as the genetic predisposition of coronary artery disease in Eastern India.
abstract: OBJECTIVE
  A case control study was designed to assess whether the prevalence of ACE gene polymorphism has any role in the development of CAD.
  
  
  METHODS
  The study included unrelated 217 cases with CAD and 255 healthy controls. PCR was done using primers followed by agarose gel electrophoresis for study of different ACE gene polymorphisms. Multiple logistic regression analysis was carried out to find association between studied genotypes and lifestyle as well as biochemical risk factors.
  
  
  RESULTS
  Both DD [OR: 2.16; 95%CI: (60.60-67.40)] and ID [OR: 1.48; 95%CI: (93.28-97.72)] genotypes of the ACE gene showed significant associations in the development of CAD. Coexistence of diabetes and hypertension found to be risk modifier of the disease. Tobacco intake in various forms elevates the risk of the disease among the cases with risk genotypes.
  
  
  CONCLUSIONS
  ID and DD genotypes of ACE gene came out to be predisposing factors for the CAD cases in our study population.
authors.affiliation: Institute of Haematology and Transfusion Medicine, Medical College, Kolkata, West Bengal, India.
authors.forename: Soujatya
authors.initials: S
authors.lastname: Dhar
authors.forename: Saumitra
authors.initials: S
authors.lastname: Ray
authors.forename: Anjanlal
authors.initials: A
authors.lastname: Dutta
authors.forename: Bani
authors.initials: B
authors.lastname: Sengupta
authors.forename: Sila
authors.initials: S
authors.lastname: Chakrabarti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D003920:Diabetes Mellitus / Q000453:epidemiology; D004587:Electrophoresis, Agar Gel; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007194:India / Q000453:epidemiology; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D007703:Peptidyl-Dipeptidase A