title: [Development trends for therapeutic antibody].
abstract: Recent developments for therapeutic antibody have provided new options for cancer treatments. Modification of antibody molecules pursuing improvement of binding efficacy for Fcgamma receptors and enabling efficient recycling of antibody have been performed. Novel constructs of antibody possessing multivalent specificity and conjugated agents have also been developed. Based on exploration of new class of target molecules for therapeutic antibody, antibodies enhancing anti-tumor immunity such as anti-CTLA-4 antibody have appeared. These advancements would achieve more effective and safer therapy for various kinds of cancers.
authors.affiliation: Department of Comprehensive Clinical Oncology, Kyushu University Graduate School of Medical Sciences.
authors.forename: Eishi
authors.initials: E
authors.lastname: Baba
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kusaba
authors.forename: Shuji
authors.initials: S
authors.lastname: Nakano
mesh_terms: D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D060908:CTLA-4 Antigen / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D018796:Immunoconjugates / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology; D017452:Receptors, IgG / Q000187:drug effects* / Q000276:immunology
chemical_list: D000906:Antibodies; D060908:CTLA-4 Antigen; D018796:Immunoconjugates; D017452:Receptors, IgG