title: XPC 939A>C and 499C>T polymorphisms and skin cancer risk: a meta-analysis.
abstract: The xeroderma pigmentosum complementation group C gene (XPC) has been identified as important for repairing UV-related DNA damage. Some subtle changes in this gene may impair repair efficiency and influence susceptibility to human cancers, including skin cancer. Two polymorphisms in XPC, 939A>C (rs2228001) and 499C>T (rs2228000), are considered to have possible associations with the risk of skin cancer, but the reported results have been inconsistent. Here we performed a meta-analysis of the available evidence regarding the relationship between these two polymorphisms and the risk of skin cancer. All relevant studies were searched using PubMed, Embase and Web of Science before February 2012. A total of 8 case-control studies were included in this analysis, and no convincing associations between the two polymorphisms and risk of skin cancer were observed in any of the genetic models. Stratified analyses by skin cancer type also did not detect significant associations in any subgroup. This meta-analysis suggested that the XPC 939A>C and 499C>T polymorphisms may have little involvement in susceptibility to skin cancer.
authors.affiliation: Department of Burns and Plastic Surgery, Taizhou People's Hospital, Taizhou, China. jg0408@163.com
authors.forename: Geng
authors.initials: G
authors.lastname: Ji
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lin
authors.forename: Song-Yu
authors.initials: SY
authors.lastname: Cao
authors.forename: Luo-Zhu
authors.initials: LZ
authors.lastname: Li
authors.forename: Xin-Long
authors.initials: XL
authors.lastname: Chen
authors.forename: Bu-Mei
authors.initials: BM
authors.lastname: Sun
authors.forename: Chuan-Jun
authors.initials: CJ
authors.lastname: Chen
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Ma
mesh_terms: D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology*
chemical_list: D004268:DNA-Binding Proteins; C086984:XPC protein, human