title: An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases.
abstract: The endoplasmic reticulum (ER) is the major site of calcium storage and protein folding. It has a unique oxidizing-folding environment due to the predominant disulfide bond formation during the process of protein folding. Alterations in the oxidative environment of the ER and also intra-ER Ca2+ cause the production of ER stress-induced reactive oxygen species (ROS). Protein disulfide isomerases, endoplasmic reticulum oxidoreductin-1, reduced glutathione and mitochondrial electron transport chain proteins also play crucial roles in ER stress-induced production of ROS. In this article, we discuss ER stress-associated ROS and related diseases, and the current understanding of the signaling transduction involved in ER stress.
authors.affiliation: Department of Pharmacology, School of Medicine, Chonbuk National Univeristy, Jeonju 561-180, South Korea. hrkim@wonkwang.ac.kr.
authors.forename: Bidur
authors.initials: B
authors.lastname: Bhandary
authors.forename: Anu
authors.initials: A
authors.lastname: Marahatta
authors.forename: Hyung-Ryong
authors.initials: HR
authors.lastname: Kim
authors.forename: Han-Jung
authors.initials: HJ
authors.lastname: Chae
mesh_terms: D000818:Animals; D004194:Disease; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D008954:Models, Biological; D017382:Reactive Oxygen Species / Q000378:metabolism; D056811:Unfolded Protein Response
chemical_list: D017382:Reactive Oxygen Species