title: Adjuvant treatment of resected nonsmall cell lung cancer:  state of the art and new potential developments.
abstract: OBJECTIVE
  Approximately 50% of surgically resected early stage lung cancer patients will relapse and die of recurrent disease within 5 years. In order to reduce the risk of relapse and improve survival, efforts have been focused on the use of chemotherapy before or after surgery. The benefit of adjuvant cisplatin-based chemotherapy is widely accepted for patients with resected stage II-IIIA, although its impact on survival is limited. There is, therefore, a need to find other strategies to further improve survival outcomes.
  
  
  RESULTS
  In recent years, there has been a marked increase in the development of novel therapeutic strategies targeting signaling pathways, such as epidermal growth factor receptor, angiogenesis, and immunotherapy in stage IV nonsmall cell lung cancer. The potential contribution of these strategies in the adjuvant setting is now being analyzed in randomized clinical trials.
  
  
  CONCLUSIONS
  At present, the challenge for research in early stage disease is to define subsets of patients who benefit from certain targeting agents and establish how to integrate such agents into the adjuvant setting.
authors.affiliation: Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain. efelip@vhebron.net
authors.forename: Enriqueta
authors.initials: E
authors.lastname: Felip
authors.forename: Alex
authors.initials: A
authors.lastname: Martinez-Marti
authors.forename: Pablo
authors.initials: P
authors.lastname: Martinez
authors.forename: Susana
authors.initials: S
authors.lastname: Cedres
authors.forename: Alejandro
authors.initials: A
authors.lastname: Navarro
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant / Q000379:methods; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D058990:Molecular Targeted Therapy
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D066246:ErbB Receptors