title: [Effect of phenformin hydrochloride on pharmacokinetics of puerarin in rats].
abstract: OBJECTIVE
  To study the effect of phenformin hydrochloride that may be illegally added in traditional Chinese medicine preparations on the pharmacokinetics of puerarin in rats.
  
  
  METHODS
  Rats were randomly divided into the single pueraria group and the phenformin hydrochloride combined with pueraria group. After oral administration in the two groups, their bloods were sampled at different time points to determine the drug concentration of puerarin in rat blood and calculate pharmacokinetic parameters.
  
  
  RESULTS
  After oral administration with pueraria extracts and phenformin hydrochloride combined with pueraria extracts, the two groups showed main pharmacokinetic parameters as follows: Cmax were (2.39 +/- 1.01), (1.03 +/- 0.35) mg x L(-1), respectively; Tmax were (0.50 +/- 0.09), (1.5 +/- 0.5) h, respectively; Ke were (0.153 +/- 0.028), (0.172 +/- 0.042) h(-1), respectively; t(1/2) were (4.65 +/- 0.86), (4.20 +/- 0.81) h, respectively; AUC(0-t), were (5.73 +/- 2.60), (5.45 +/- 1.81) mg x h x L(-1), respectively; AUC(0-infinity) were (6.72 +/- 2.89), (6.26 +/- 1.88) mg x h x L(-1), respectively. Compared with the single puerarin group, the Cmax was significantly decreased (P < 0.05) and the Tmax was markedly longer (P < 0.01) than the hydrochloride combined with pueraria group.
  
  
  CONCLUSIONS
  Phenformin hydrochloride can slow down the absorption process of puerarin and change the pharmacokinetic process of puerarin to some extent.
authors.affiliation: School of pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Deng
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Mei
authors.initials: M
authors.lastname: Cui
authors.forename: Zhi-li
authors.initials: ZL
authors.lastname: Xiong
authors.forename: Fa-mei
authors.initials: FM
authors.lastname: Li
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004347:Drug Interactions; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007529:Isoflavones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D010629:Phenformin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D007004:Hypoglycemic Agents; D007529:Isoflavones; D014665:Vasodilator Agents; D010629:Phenformin; C033607:puerarin