title: BAG6/BAT3: emerging roles in quality control for nascent polypeptides.
abstract: BAG6 (also known as BAT3/Scythe) is a ubiquitin-like protein that is thought to participate in a variety of seemingly unrelated physiological and pathological processes, such as apoptosis, antigen presentation and the T-cell response. Recent studies have shown that BAG6 is essential for the quality control of aggregation-prone polypeptide biogenesis. It forms part of a complex that determines the fate of newly synthesized client proteins for membrane insertion, ubiquitin-mediated degradation and/or aggregate formation. A biologically relevant transmembrane protein family has recently been shown to be a major client of BAG6, suggesting that many of the known diverse BAG6 functions can be interpreted by BAG6-mediated control of membrane protein biogenesis. In this review, we summarize the current understanding of the physiological roles of BAG6 with a particular focus on quality control for nascent chain polypeptides.
authors.affiliation: Department of Biological Sciences, Laboratory of Cell Biology and Biochemistry, Tokyo Metropolitan University, Tokyo, Japan. hkawa@tmu.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawahara
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Minami
authors.forename: Naoto
authors.initials: N
authors.lastname: Yokota
mesh_terms: D000818:Animals; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism
chemical_list: C092009:BAG6 protein, human; D018832:Molecular Chaperones; D010455:Peptides; D046988:Proteasome Endopeptidase Complex