title: Low-grade and high-grade serous Mullerian carcinoma: review and analysis of publicly available gene expression profiles.
abstract: OBJECTIVE
  Mullerian low grade serous carcinoma (LGSC) and high grade serous carcinoma (HGSC) have distinct molecular profiles, clinical behavior and treatment response. Our objective was to study the biological profiles of these carcinomas.
  
  
  METHODS
  This study examines publicly available gene expression profiles of LGSC and HGSC to identify differentially expressed genes and key pathways involved in carcinogenesis and chemotherapy response.
  
  
  RESULTS
  Our analysis supports the hypothesis that serous mullerian carcinoma develop through two different pathways yielding two distinct malignancies, namely LGSC and HGSC. Furthermore, genes potentially involved in chemotherapeutic resistance of LGSC were identified. Suppressing the levels of these genes/proteins may increase clinical response to standard chemotherapy in patients with LGSC.
  
  
  CONCLUSIONS
  In summary, this review shows the molecular profile of LGSC and HGSC through multi-center analysis of gene expression profiles of these tumors. The gene signatures of these neoplasms may potentially be used to develop disease-specific, targeted therapy for LGSC and HGSC.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. tmay1@partners.org
authors.forename: Taymaa
authors.initials: T
authors.lastname: May
authors.forename: Melina
authors.initials: M
authors.lastname: Shoni
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Crum
authors.forename: Wa
authors.initials: W
authors.lastname: Xian
authors.forename: Vinod
authors.initials: V
authors.lastname: Vathipadiekal
authors.forename: Michael
authors.initials: M
authors.lastname: Birrer
authors.forename: Barry
authors.initials: B
authors.lastname: Rosen
authors.forename: Alicia
authors.initials: A
authors.lastname: Tone
authors.forename: K Joan
authors.initials: KJ
authors.lastname: Murphy
mesh_terms: D018284:Cystadenocarcinoma, Serous / Q000235:genetics* / Q000473:pathology; D005185:Fallopian Tube Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D018200:Mixed Tumor, Mullerian / Q000235:genetics* / Q000473:pathology; D060787:Neoplasm Grading; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D059467:Transcriptome