title: Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.
abstract: This study investigates the potential role of 17 chosen polymorphisms in 15 candidate genes and the risk of myocardial infarction in patients under 45 years of age. The study consists of 271 patients with myocardial infarction and 141 controls. The analysis of genetic polymorphisms was performed using the PCR-RFLP method. Of the chosen polymorphisms, two (Leu125Val PECAM1 and A1/A2 FVII) are related to myocardial infarction and two (C677T MTHFR and 5A/6A MMP3) to advanced stenosis in arterial vessels (> 75%). We also found that the frequency of some combinations among the analyzed genes and environmental factors varied between the patient and control groups.
authors.affiliation: Department of Medical Biotechnology, Medical University of Lodz, Zeligowskiego 7/9, 90-725, Lodz, Poland. agata.sakowicz@gmail.com
authors.forename: Agata
authors.initials: A
authors.lastname: Sakowicz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Fendler
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Lelonek
authors.forename: Bartosz
authors.initials: B
authors.lastname: Sakowicz
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Pietrucha
mesh_terms: D000328:Adult; D000367:Age Factors; D050197:Atherosclerosis / Q000209:etiology / Q000235:genetics; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000235:genetics; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000235:genetics
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3