title: Jaws features in Type 1 Gaucher disease.
abstract: OBJECTIVE
  Our aims were to present 2 new cases of Gaucher disease involving the jaws and to review the literature.
  
  
  METHODS
  Two new cases and the literature from 1982-2011 were reviewed.
  
  
  RESULTS
  Ten articles describing 35 cases (for a total of 37 with 2 new cases presented) were analyzed. The mandible and maxilla were affected in 97.3% and 24.3% of the reported cases, respectively. Generalized rarefaction of bone (osteopenia) was present in 83.8%, and well-defined radiolucent lesions in 40.5%. The effects on the surrounding structures included loss of cortication of the mandibular canal (56.7%), cortical bone thinning (27%), expansion, root resorption (24.3%), mandibular canal displacement (18.9%), cortical perforation, maxillary sinus obliteration, and tooth displacement (10.8%).
  
  
  CONCLUSIONS
  Two distinct bone abnormalities with separate pathophysiologies, radiographic presentation, and effects on the surrounding structures are suggested: 1) generalized mandibular/maxillary osteopenia and 2) a well-defined radiolucent lesion, which appears only in the mandible. This review refutes 2 accepted assumptions; according to the results, 1) the most common manifestation is generalized osteopenia (and the resulting mandibular canal changes), whereas the well-defined radiolucent lesion is the next most common, and 2) cortical bone thinning/perforations and lamina dura thinning are not uncommon in these patients.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Rabin Medical Center, Beilinson Campus, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: Itai
authors.initials: I
authors.lastname: Zeevi
authors.forename: Yakir
authors.initials: Y
authors.lastname: Anavi
authors.forename: Ilana
authors.initials: I
authors.lastname: Kaplan
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Zadik
mesh_terms: D000328:Adult; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D005776:Gaucher Disease / Q000150:complications*; D006801:Humans; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology*; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D008439:Maxillary Diseases / Q000209:etiology; D014057:Tomography, X-Ray Computed