title: The rotavirus experience in Mexico: discovery to control.
abstract: The recent introduction of a rotavirus vaccine program in Mexico to control rotavirus disease, a common killer of children worldwide, has dramatically reduced the number of Mexican children dying and being hospitalized because of diarrhea. The successful introduction of a rotavirus vaccine program was preceded by several decades of focused research efforts to document the burden of disease and to generate the knowledge base to develop and deploy a vaccine. The postlicensure experience from Mexico demonstrates that evaluating the impact and safety of the vaccination program is vitally necessary for sustaining it. All in all, the immensely successful Mexico experience with control of rotavirus disease, if copied, could yield tremendously favorable results for children and parents worldwide.
authors.affiliation: National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. aul3@cdc.gov
authors.forename: Manish M
authors.initials: MM
authors.lastname: Patel
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
authors.forename: Mathuram
authors.initials: M
authors.lastname: Santosham
authors.forename: Vesta
authors.initials: V
authors.lastname: Richardson
mesh_terms: D002675:Child, Preschool; D006801:Humans; D017589:Immunization Programs / Q000379:methods; D007223:Infant; D008800:Mexico; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage*; D014611:Vaccination / Q000379:methods; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: C492457:RIX4414 vaccine; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated