title: [Relationship between rs1057141 and rs1135216 polymorphisms of TAP1 gene and allergic rhinitis in Xinjiang Han people].
abstract: OBJECTIVE
  To investigate the association between transporter associated with antigen processing 1 (TAP1) rs1057141 and rs1135216 gene polymorphisms and predisposition to allergic rhinitis (AR) in Xinjiang Han people.
  
  
  METHODS
  A case control study was conducted. The region of the TAP1 * rs1057141 and rs1135216 was studied in 150 Xinjiang Han people with allergic rhinitis and 150 normal controls by using SNaPshot system, and these data were compared with other ethics groups in the world according to the NCBI gene bank.
  
  
  RESULTS
  The genotypes distribution of the group were in the Hardy-Weinberg equilibrium(P>0.05). The frequencies of three genotypes(G/G, G/A, A/A) of TAP1 * rs1057141 were 4.00%, 30.00%, 66.00% in controls and 2.70%, 33.30%, 64.00% in AR groups , which showed no difference (P>0.05). The frequencies of three genotypes (G/G,G/A,A/A) of TAP1 * rs1135216 were 2.0%, 28.7%, 69.3% in controls and 1.30%, 27.30%, 71.40% in AR groups, which showed no difference either (P>0.05). According to the NCBI database, there was difference between Xinjiang Han people and other ethnics in the world.
  
  
  CONCLUSIONS
  Lacking association was found between the mutation of TAP1 * rs1057141, rs1135216 gene G allele and allergic rhinitis in the Xinjiang Han people. Maybe TAP1 * rs1057141, rs1135216 were not susceptibility genes to AR. And apparent differences existed in TAP1 gene polymorphisms between Xinjiang Han people and other ethnic groups in the world.
authors.affiliation: Department of Otorhinolaryngology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
authors.forename: Qingyong
authors.initials: Q
authors.lastname: Chen
authors.forename: Zhilian
authors.initials: Z
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology / Q000235:genetics*
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; C073119:TAP1 protein, human