title: Synthesis, in vitro antibacterial and antifungal activity of some n-acetylated and non-acetylated pyrazolines.
abstract: Fourteen new N-acetylated and non-acetylated pyrazoline derivatives were synthesized by reacting chalcones with hydrazine in the presence of absolute ethanol however reaction was carried out in the presence of glacial acetic acid to afford N-acetylated pyrazolines. The chemical structures of the synthesized pyrazolines were confirmed by FTIR, (1)HNMR, (13)CNMR and mass spectroscopic data. The pyrazolines (1-14) were screened for antibacterial activity against ten bacterial strains using seven Gram-positive and three Gram-negative bacteria and antifungal activity against Aspergillus flavus, Aspergillus niger and Aspergillus pterus. Pyrazolines (1-14) found to exhibit good to excellent antimicrobial activities compared to the levofloxacin and fluconazole used as standard drugs.
authors.affiliation: Chemistry Department, Quaid-i-azam University, Islamabad, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Baseer
authors.forename: Farzana Latif
authors.initials: FL
authors.lastname: Ansari
authors.forename: Zaman
authors.initials: Z
authors.lastname: Ashraf
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D000107:Acetylation; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D047188:Chalcones / Q000737:chemistry; D015725:Fluconazole / Q000494:pharmacology; D006834:Hydrazines / Q000737:chemistry; D064704:Levofloxacin; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D015242:Ofloxacin / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D047188:Chalcones; D006834:Hydrazines; D011720:Pyrazoles; C029424:hydrazine; D064704:Levofloxacin; D015725:Fluconazole; D015242:Ofloxacin; D019342:Acetic Acid