title: Contribution of donor and recipient characteristics to short- and long-term pancreas graft survival.
abstract: BACKGROUND
  Many donor and recipient factors are known to affect pancreas graft survival. However, their relative importance in explaining differences in graft survival is unknown. Purpose of this study was to retrospectively evaluate the impact of donor and recipient factors on pancreas graft survival, and compare their contribution in explaining graft survival differences.
  
  
  METHODS
  Patient records of all 170 pancreas transplantations (158 Simultaneous Pancreas-Kidney; 12 Pancreas-after-kidney) in the period 1997-2008 were reviewed retrospectively to assess recipient factors before/during transplantation, and to assess graft survival. Eurotransplant reports were reviewed to assess donor factors.
  
  
  RESULTS
  Death-censored 1-year graft survival was 88.4% and 82.3% at 3 years. Several factors significantly influenced graft survival: female recipient gender (Hazard Ratio (HR) 2.81[1.10-7.14]), enteric graft drainage (HR 2.85[1.15-7.05]), and donor-recipient match on BMI (HR 2.46[1.01-6.02]). None of the donor factors significantly affected survival. Similar results were found for 1-year survival, except for enteric graft drainage and donor-recipient BMI matching. In total, donor factors explained 3.6% and recipient factors 10.0% of the variance in graft survival. Donor factors were more important for 1-year survival (3.1%), but still less important than recipient factors which explained 6.4%.
  
  
  CONCLUSIONS
  Recipient factors are more important in explaining differences in pancreas graft survival than donor factors.
authors.affiliation: Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Denise E
authors.initials: DE
authors.lastname: Hilling
authors.forename: Andrzej G
authors.initials: AG
authors.lastname: Baranski
authors.forename: Ada
authors.initials: A
authors.lastname: Haasnoot
authors.forename: Paul J M
authors.initials: PJ
authors.lastname: van der Boog
authors.forename: Onno T
authors.initials: OT
authors.lastname: Terpstra
authors.forename: Perla J
authors.initials: PJ
authors.lastname: Marang-van de Mheen
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D046148:Donor Selection; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D016035:Pancreas Transplantation; D019990:Perioperative Care; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012737:Sex Factors; D014019:Tissue Donors / Q000706:statistics & numerical data; D016896:Treatment Outcome