title: Continuous flow Sonogashira C-C coupling using a heterogeneous palladium-copper dual reactor.
abstract: We report the development of a heterogeneous catalyst system on continuous flow chemistry. A palladium (Pd) coated tubular reactor was placed in line with copper (Cu) tubing using a continuous flow platform, and a Sonogashira C-C coupling reaction was used to evaluate the performance. The reactions were favorably carried out in the Cu reactor, catalyzed by the traces of leached Pd from the Pd reactor. The leached Pd and Cu were trapped with a metal scavaging resin at the back-end of the continuous flow system, affording a genuine approach toward green chemistry.
authors.affiliation: School of Chemical and Life Sciences, Singapore Polytechnic, 500 Dover Road, Singapore 139651, Singapore.
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Tan
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Sem
authors.forename: Wei-Yuan
authors.initials: WY
authors.lastname: Chong
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Liu
authors.lastname: Hendra
authors.forename: Wei Lek
authors.initials: WL
authors.lastname: Kwan
authors.forename: Chi-Lik Ken
authors.initials: CL
authors.lastname: Lee
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000295:instrumentation* / Q000379:methods; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D010165:Palladium; D003300:Copper