title: Characterization of flavonoids and naphthopyranones in methanol extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSn and their mutagenic activity.
abstract: A HPLC-ESI-IT-MSn method, based on high-performance liquid chromatography coupled to electrospray negative ionization multistage ion trap mass spectrometry, was developed for rapid identification of 24 flavonoid and naphthopyranone compounds. The methanol extracts of the capitulae and scapes of P. chiquitensis exhibited mutagenic activity in the Salmonella/microsome assay, against strain TA97a.
authors.affiliation: Department of Organic Chemistry, Institute of Chemistry, UNESP-Sao Paulo State University, Araraquara CEP 14800-900, Sao Paulo, Brazil.
authors.forename: Fabiana Volpe
authors.initials: FV
authors.lastname: Zanutto
authors.forename: Paula Karina
authors.initials: PK
authors.lastname: Boldrin
authors.forename: Eliana Aparecida
authors.initials: EA
authors.lastname: Varanda
authors.forename: Samara
authors.initials: S
authors.lastname: Fernandes de Souza
authors.forename: Paulo Takeo
authors.initials: PT
authors.lastname: Sano
authors.forename: Wagner
authors.initials: W
authors.lastname: Vilegas
authors.forename: Lourdes
authors.initials: L
authors.lastname: Campaner dos Santos
mesh_terms: D002851:Chromatography, High Pressure Liquid; D039262:Eriocaulaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D009153:Mutagens / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D012475:Salmonella / Q000187:drug effects / Q000254:growth & development; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry
chemical_list: D005419:Flavonoids; D009153:Mutagens; D010936:Plant Extracts