title: Cardiovascular effects of anti-diabetic medications in type 2 diabetes mellitus.
abstract: Over the past several years, there have been a significant number of new agents developed for the treatment of type 2 diabetes. Our goal in this article is to review the cardiovascular effects (risks and benefits) of these oral and non-insulin injectable agents. We review six major categories of diabetic therapies: biguanides, sulfonylureas, alpha-glucosidase inhibitors, thiazolidinediones, GLP-1 agonists, and DPP-IV inhibitors. In order to achieve a personalized regimen that aims for optimal outcomes, we must take into consideration each drug's side effects, patients' cardiovascular risk factors, and their individual health profile.
authors.affiliation: Center for Diabetes Research and Treatment, University of California, Irvine, 92697, USA. samars@uci.edu
authors.forename: Samar
authors.initials: S
authors.lastname: Singh
authors.forename: Jyoti
authors.initials: J
authors.lastname: Bhat
authors.forename: Ping H
authors.initials: PH
authors.lastname: Wang
mesh_terms: D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D007004:Hypoglycemic Agents