title: [Melasma and aspects of pigmentary disorders in Asians].
abstract: Pigmentary changes in Asians are larger problems and more important features of aging than wrinkles. Melasma is a commonly observed epidermal hypermelanosis of the face in Asians. The altered dermal structures and impaired basement membrane are thought to have an influence on the development of epidermal hyperpigmentation of melasma. Dermal hyperpigmentary diseases are particularly common in Asians. Acquired bilateral melanosis of the neck is a characteristic dermal melanotic condition primarily of the neck in peri-menopausal women. It is characterized by marked accumulation of dermal pigment with perivascular lymphocytic infiltration. The cases seem to represent a continuum of Riehl's melanosis. Subclinical injury or inflammation may play a role as possible causative factors for the development of the pigmentation.
authors.affiliation: Service de Dermatologie, Ajou University School of Medicine, Suwon, Corée. hykang@ajou.ac.kr
authors.forename: H Y
authors.initials: HY
authors.lastname: Kang
mesh_terms: D044466:Asian People / Q000235:genetics; D001485:Basement Membrane / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D017495:Hyperpigmentation / Q000175:diagnosis / Q000208:ethnology* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D019746:Intramolecular Oxidoreductases / Q000235:genetics; D020778:Matrix Metalloproteinase 2 / Q000235:genetics; D008543:Melanins / Q000096:biosynthesis; D008548:Melanosis / Q000175:diagnosis / Q000208:ethnology* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D008562:Membrane Glycoproteins / Q000235:genetics; D051739:Microphthalmia-Associated Transcription Factor / Q000235:genetics; D009333:Neck; D010088:Oxidoreductases / Q000235:genetics; D047648:Perimenopause / Q000502:physiology; D056910:Republic of Korea; D012307:Risk Factors; D012867:Skin / Q000473:pathology
chemical_list: C497234:MITF protein, human; D008543:Melanins; D008562:Membrane Glycoproteins; D051739:Microphthalmia-Associated Transcription Factor; D010088:Oxidoreductases; C489799:TYRP1 protein, human; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D019746:Intramolecular Oxidoreductases; C042501:dopachrome isomerase