title: Nano-crystalline diamond-coated titanium dental implants - a histomorphometric study in adult domestic pigs.
abstract: Promising biomaterial characteristics of diamond-coatings in biomedicine have been described in the literature. However, there is a lack of knowledge about implant osseointegration of this surface modification compared to the currently used sandblasted acid-etched Ti-Al6-V4 implants. The aim of this study was to investigate the osseointegration of microwave plasma-chemical-vapour deposition (MWP-CVD) diamond-coated Ti-Al6-V4 dental implants after healing periods of 2 and 5 months. Twenty-four MWP-CVD diamond-coated and 24 un-coated dental titanium-alloy implants (Ankylos(®)) were placed in the frontal skull of eight adult domestic pigs. To evaluate the effects of the nano-structured surfaces on bone formation, a histomorphometric analysis was performed after 2 and 5 months of implant healing. Histomorphometry analysed the bone-to-implant contact (BIC). No significant difference in BIC for the diamond-coated implants in comparison to reference implants could be observed for both healing periods. Scanning electron microscopy revealed an adequate interface between the bone and the diamond surface. No delamination or particle-dissociation due to shearing forces could be detected. In this study, diamond-coated dental titanium-alloy implants and sandblasted acid-etched implants showed a comparable degree of osseointegration.
authors.affiliation: Department of Cranio-Maxillofacial and Oral Surgery, University Hospital of Zurich, Switzerland. Philipp.Metzler@usz.ch
authors.forename: Philipp
authors.initials: P
authors.lastname: Metzler
authors.forename: Cornelius
authors.initials: C
authors.lastname: von Wilmowsky
authors.forename: Bernd
authors.initials: B
authors.lastname: Stadlinger
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Zemann
authors.forename: Karl Andreas
authors.initials: KA
authors.lastname: Schlegel
authors.forename: Stephan
authors.initials: S
authors.lastname: Rosiwal
authors.forename: Stephan
authors.initials: S
authors.lastname: Rupprecht
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D000497:Alloys; D000537:Aluminum Oxide / Q000737:chemistry; D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003722:Dental Alloys / Q000737:chemistry*; D045662:Dental Etching / Q000379:methods; D015921:Dental Implants; D017267:Dental Prosthesis Design; D018130:Diamond / Q000737:chemistry*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008855:Microscopy, Electron, Scanning; D008872:Microwaves; D053758:Nanoparticles / Q000737:chemistry*; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D058626:Plasma Gases / Q000737:chemistry; D011897:Random Allocation; D013314:Stress, Mechanical; D013499:Surface Properties; D013552:Swine; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D014835:Volatilization
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; D003722:Dental Alloys; D015921:Dental Implants; D058626:Plasma Gases; C031462:titanium alloy (TiAl6V4); D018130:Diamond; D014025:Titanium; D000537:Aluminum Oxide