title: Biodentine used as a pulp-capping agent in primary pig teeth.
abstract: OBJECTIVE
  The purpose of this study was to assess and compare, in primary pig teeth, the pulp response after a pulpotomy using either Biodentine (a new tricalcium-silicate cement), white mineral trioxide aggregate (WMTA), or formocresol (FC) and repeat the same after direct pulp  capping using either Biodentine, WMTA, or calcium hydroxide.
  
  
  METHODS
  A total of 180 primary teeth from 9 healthy 4-month-old female pigs were divided into 3 experimental periods (7, 28, and 90 days) for each material used for the pulpotomy and direct pulp capping treatments. Seven,  28, and 90 days later, the animals were euthanized and the specimens were prepared for histological examination and evaluation. The data collected from the histological examinations were statistically analyzed using Kruskal-Wallis and Dunn multiple comparison tests.
  
  
  RESULTS
  In pulpotomy  groups, there was a significant difference between Biodentine and WMTA vs FC in terms of inflammatory cell response and hard tissue formation. In direct pulp capping groups, there was only a significant difference between Biodentine and calcium hydroxide in terms of hard tissue formation in  a 7-day period.
  
  
  CONCLUSIONS
  Biodentine and white mineral trioxide aggregate are both suitable, biocompatible materials for pulp capping in primary teeth of pigs.
authors.affiliation: Queen Fabiola Children's University Hospital, Department of Pediatric Dentistry, Free University of Brussels, Brussels, Belgium. shayegan_amir@hotmail.com
authors.forename: Amir
authors.initials: A
authors.lastname: Shayegan
authors.forename: Cédric
authors.initials: C
authors.lastname: Jurysta
authors.forename: Ramin
authors.initials: R
authors.lastname: Atash
authors.forename: Michel
authors.initials: M
authors.lastname: Petein
authors.forename: Astrid Vanden
authors.initials: AV
authors.lastname: Abbeele
mesh_terms: D017607:Aluminum Compounds / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D017610:Calcium Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D002126:Calcium Hydroxide / Q000494:pharmacology / Q000627:therapeutic use; D003782:Dental Pulp / Q000187:drug effects*; D003785:Dental Pulp Capping / Q000379:methods*; D003809:Dentin, Secondary / Q000378:metabolism; D004338:Drug Combinations; D005260:Female; D005566:Formocresols / Q000494:pharmacology / Q000627:therapeutic use; D010087:Oxides / Q000494:pharmacology / Q000627:therapeutic use; D057872:Pulp Capping and Pulpectomy Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011672:Pulpotomy / Q000379:methods; D012387:Root Canal Filling Materials / Q000494:pharmacology / Q000627:therapeutic use; D017640:Silicates / Q000494:pharmacology / Q000627:therapeutic use*; D034421:Sus scrofa; D014094:Tooth, Deciduous
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D005566:Formocresols; D010087:Oxides; D057872:Pulp Capping and Pulpectomy Agents; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; C031025:formocresol; C506393:tricalcium silicate; D002126:Calcium Hydroxide