title: Prenatal diagnosis of a fetus with a ring chromosome 20 characterized by array-CGH.
abstract: OBJECTIVE
  a fetus with a ring chromosome 20 is presented.
  
  
  METHODS
  at 16 weeks' gestation, ultrasound examination evidenced no apparent structural malformation. Amniocentesis was performed for maternal anxiety.
  
  
  RESULTS
  chromosome analysis identified a ring chromosome 20 and array-CGH demonstrated that the ring including micro-deletion of the short arm in 20p13, that was extended for about 632.2 kb and a micro-deletion of the long arm in 20q13.33 region.
  
  
  CONCLUSIONS
  this is the first case of a ring chromosome 20 diagnosed prenatally. This reinforces the importance of offering amniocentesis with a-CGH to make more accurate prenatal diagnosis.
authors.affiliation: Department of Prenatal Diagnosis, Artemisia Fetal-Maternal Medical Center, Rome, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Cignini
authors.forename: Nella
authors.initials: N
authors.lastname: Dugo
authors.forename: Claudio
authors.initials: C
authors.lastname: Giorlandino
authors.forename: Rosaria
authors.initials: R
authors.lastname: Gauci
authors.forename: Anna
authors.initials: A
authors.lastname: Spata
authors.forename: Stella
authors.initials: S
authors.lastname: Capriglione
authors.forename: Ester Valentina
authors.initials: EV
authors.lastname: Cafà