title: Exercise-induced bronchoconstriction in school-age children born extremely preterm.
abstract: BACKGROUND
  School children born preterm often show airway hyperresponsiveness to methacholine or histamine. Less attention has been paid to their airway response to exercise, an important point because of the role of exercise in the child's daily life. The aim of this study was to describe the characteristics of, and potential determinants to, the airway response to exercise in children born extremely preterm.
  
  
  METHODS
  Forty-two nonasthmatic nonatopic children born before 32 wk gestation were compared with 27 healthy nonasthmatic nonatopic term children at age 7. Spirometry and respiratory impedance were measured at baseline and repeated after a single-step 6-min treadmill exercise in a climate-controlled room.
  
  
  RESULTS
  The preterm group showed significant broncho-constriction induced by exercise. Prematurity, but not low baseline lung function, neonatal oxygen supplementation, mechanical ventilation, chronic lung disease, or maternal smoking, was a determinant of exercise-induced bronchoconstriction.
  
  
  CONCLUSIONS
  Children born extremely preterm present significant exercise-induced airway obstruction at age 7. The response has different characteristics from that occurring in asthmatics and is likely to express airway noneosinophilic inflammation.
authors.affiliation: Department of Neonatal Medicine, Regional Maternity Hospital, Nancy, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Hamon
authors.forename: Silvia
authors.initials: S
authors.lastname: Varechova
authors.forename: Rachel
authors.initials: R
authors.lastname: Vieux
authors.forename: Iulia
authors.initials: I
authors.lastname: Ioan
authors.forename: Claude
authors.initials: C
authors.lastname: Bonabel
authors.forename: Cyril
authors.initials: C
authors.lastname: Schweitzer
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Hascoet
authors.forename: François
authors.initials: F
authors.lastname: Marchal
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016084:Bronchoconstriction; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume; D005865:Gestational Age; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D016014:Linear Models; D008168:Lung / Q000254:growth & development*; D008297:Male; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects; D011237:Predictive Value of Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000009:adverse effects; D012307:Risk Factors; D013147:Spirometry; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D014797:Vital Capacity
chemical_list: D014028:Tobacco Smoke Pollution