title: Cobalt derivatives as promising therapeutic agents.
abstract: Inorganic complexes are versatile platforms for the development of potent and selective pharmaceutical agents. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates. Investigations into the mechanism of cobalt therapeutic agents can provide valuable insight into the physicochemical properties that can be harnessed for drug development. This review presents examples of bioactive cobalt complexes with special attention to their mechanisms of action. Specifically, cobalt complexes that elicit biological effects through protein inhibition, modification of drug activity, and bioreductive activation are discussed. Insights gained from these examples reveal features of cobalt that can be rationally tuned to produce therapeutics with high specificity and improved efficacy for the biomolecule or pathway of interest.
authors.affiliation: Department of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, Evanston, IL 60208-3113, United States.
authors.forename: Marie C
authors.initials: MC
authors.lastname: Heffern
authors.forename: Natsuho
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Holbrook
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Eckermann
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Meade
mesh_terms: D003035:Cobalt / Q000737:chemistry* / Q000494:pharmacology*; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D008958:Models, Molecular
chemical_list: D056831:Coordination Complexes; D003035:Cobalt