title: Hypertension-misattributed kidney disease in African Americans.
abstract: Lipkowitz et al. extend the African American Study of Kidney Disease and Hypertension to the level of genetic epidemiology, in a case-control study design. Analysis of genotypes at the APOL1 kidney disease risk region supports a paradigm shift in which genetic risk is proximate to both kidney disease and hypertension. The findings mandate urgency in clarifying mechanisms whereby APOL1 region risk variants interact with environmental triggers to cause progressive kidney disease accompanied by dangerous hypertension.
authors.affiliation: Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Rambam Health Care Campus, Haifa, Israel. skorecki@tx.technion.ac.il
authors.forename: Karl L
authors.initials: KL
authors.lastname: Skorecki
authors.forename: Walter G
authors.initials: WG
authors.lastname: Wasser
mesh_terms: D001741:Black or African American / Q000208:ethnology* / Q000235:genetics*; D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000235:genetics*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D006977:Hypertension, Renal / Q000208:ethnology* / Q000235:genetics*; D007668:Kidney / Q000503:physiopathology*; D008075:Lipoproteins, HDL / Q000235:genetics*; D008297:Male; D009393:Nephritis / Q000208:ethnology* / Q000235:genetics*
chemical_list: C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D008075:Lipoproteins, HDL