title: Capture and stimulated release of circulating tumor cells on polymer-grafted silicon nanostructures.
abstract: A platform for capture and release of circulating tumor cells is demonstrated by utilizing polymer grafted silicon nanowires. In this platform, integration of ligand-receptor recognition, nanostructure amplification, and thermal responsive polymers enables a highly efficient and selective capture of cancer cells. Subsequently, these captured cells are released upon a physical stimulation with outstanding cell viability.
authors.affiliation: Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095-1770, USA.
authors.forename: Shuang
authors.initials: S
authors.lastname: Hou
authors.forename: Haichao
authors.initials: H
authors.lastname: Zhao
authors.forename: Libo
authors.initials: L
authors.lastname: Zhao
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Shen
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Wei
authors.forename: Daniel Y
authors.initials: DY
authors.lastname: Suh
authors.forename: Aiko
authors.initials: A
authors.lastname: Nakao
authors.forename: Mitch A
authors.initials: MA
authors.lastname: Garcia
authors.forename: Min
authors.initials: M
authors.lastname: Song
authors.forename: Tom
authors.initials: T
authors.lastname: Lee
authors.forename: Bin
authors.initials: B
authors.lastname: Xiong
authors.forename: Shyh-Chyang
authors.initials: SC
authors.lastname: Luo
authors.forename: Hsian-Rong
authors.initials: HR
authors.lastname: Tseng
authors.forename: Hsiao-hua
authors.initials: HH
authors.lastname: Yu
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000906:Antibodies / Q000737:chemistry / Q000276:immunology; D000951:Antigens, Neoplasm / Q000737:chemistry / Q000276:immunology; D001710:Biotin / Q000737:chemistry / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000276:immunology; D045744:Cell Line, Tumor; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods*; D000071858:Epithelial Cell Adhesion Molecule; D006801:Humans; D061986:MCF-7 Cells; D053770:Nanowires / Q000737:chemistry*; D009360:Neoplastic Cells, Circulating; D011108:Polymers / Q000737:chemistry; D012825:Silicon / Q000737:chemistry*; D019809:Streptavidin / Q000737:chemistry / Q000378:metabolism
chemical_list: D000180:Acrylic Resins; D000906:Antibodies; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D000071858:Epithelial Cell Adhesion Molecule; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D001710:Biotin; D019809:Streptavidin; D012825:Silicon