title: Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression.
abstract: Klotho is a protein that exerts paracrine and endocrine functions. In chronic kidney disease (CKD), its expression is decreased in several tissues. This decrease probably plays important roles in various complications associated with CKD, in both a fibroblast growth factor-23 (FGF23)-dependent and an FGF23-independent manner. The clinical diagnosis of Klotho deficiency is not easy. The relevance of circulating Klotho levels, if any, needs to be adequately defined. Serum Klotho may not reflect tissue Klotho concentration.
authors.affiliation: UFR de Médecine et de Pharmacie, Unité 1088 de l'Inserm, Université de Picardie Jules Verne, Amiens, France. tilman.drueke@inserm.fr
authors.forename: Tilman B
authors.initials: TB
authors.lastname: Drüeke
authors.forename: Ziad A
authors.initials: ZA
authors.lastname: Massy
mesh_terms: D005260:Female; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase / Q000097:blood*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D000090265:Klotho Proteins; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000175:diagnosis*; D012720:Severity of Illness Index
chemical_list: C000717427:FGF23 protein, human; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins