title: [Detailed methodological recommendations for the treatment of Clostridium difficile-associated diarrhea with faecal transplantation].
abstract: The incidence of Clostridium difficile associated enteral disease shows dramatic increase worldwide, with appallingly high treatment costs, mortality figures, recurrence rates and treatment refractoriness. It is not surprising, that there is significant interest in the development and introduction of alternative therapeutic strategies. Among these only stool transplantation (or faecal bacteriotherapy) is gaining international acceptance due to its excellent cure rate (≈92%), low recurrence rate (≈6%), safety and cost-effectiveness. Unfortunately faecal transplantation is not available for most patients, although based on promising international results, its introduction into the routine clinical practice is well justified and widely expected. The authors would like to facilitate this process, by presenting a detailed faecal transplantation protocol prepared in their Institution based on the available literature and clinical rationality. Officially accepted national methodological guidelines will need to be issued in the future, founded on the expert opinion of relevant professional societies and upcoming advances in this field.
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Belgyógyászati Intézet, Intenzív Terápiás Osztály Debrecen Nagyerdei. ngergely@hotmail.com
authors.forename: Gergely György
authors.initials: GG
authors.lastname: Nagy
authors.forename: Csaba
authors.initials: C
authors.lastname: Várvölgyi
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Balogh
authors.forename: Piroska
authors.initials: P
authors.lastname: Orosi
authors.forename: György
authors.initials: G
authors.lastname: Paragh
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016360:Clostridioides difficile / Q000302:isolation & purification; D003967:Diarrhea / Q000382:microbiology*; D004761:Enterocolitis, Pseudomembranous / Q000150:complications / Q000628:therapy*; D005243:Feces; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D013242:Sterilization; D014184:Transplantation, Homologous / Q000295:instrumentation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents