title: Tri- and diorganotin(IV) complexes of biologically important orotic acid: synthesis, spectroscopic studies, in vitro anti-cancer, DNA fragmentation, enzyme assays and in vivo anti-inflammatory activities.
abstract: Tri-and diorganotin(IV) orotates of general formula, R(n)Sn(H(2)Or)(m) [n = 3/2, m = 1/2, R = Me, n-Bu, n-Oct and Ph; H(2)Or(-) = monoanion of orotic acid (H(3)Or)] (n-Bu(2)Sn(HOr) as an exception) have been synthesized. On the basis of various spectroscopic studies it is revealed that R(3)Sn(H(2)Or) and R(2)Sn(H(2)Or)(2) exhibit distorted trigonal-bipyramidal and distorted octahedral geometry, respectively, and n-Bu(2)Sn(HOr) shows both five and six coordination geometry around tin. In vitro anti-cancer screening against MCF-7 (mammary), HEK-293 (kidney), PC-3 (prostate), HCT-15 (colon) and HepG-2 (liver) cancer cell lines suggest that the n-Oct(2)Sn(H(2)Or)(2) is the most active complex among all of the studied complexes. DNA fragmentation and antioxidant enzyme assays suggest that cytotoxic effect of the complexes is selectively mediated through the induction of apoptosis. They also exhibit low toxicity and good anti-inflammatory activity (in vivo).
authors.affiliation: Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India. malanfcy@iitr.ernet.in
authors.forename: Mala
authors.initials: M
authors.lastname: Nath
authors.forename: Monika
authors.initials: M
authors.lastname: Vats
authors.forename: Partha
authors.initials: P
authors.lastname: Roy
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D053938:DNA Fragmentation / Q000187:drug effects*; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D051379:Mice; D015394:Molecular Structure; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009963:Orotic Acid / Q000737:chemistry*; D014001:Tin / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D009947:Organotin Compounds; D009963:Orotic Acid; D014001:Tin