title: Identifying risk factors for allogenic blood transfusion in oral and oropharyngeal cancer surgery with free flap reconstruction.
abstract: OBJECTIVE
  Several observational studies in head and neck cancer have reported that allogenic blood transfusion is associated with increased postoperative complications, increased risk of tumor recurrence, and worse prognosis. The aim of this study was to identify preoperative and intraoperative factors predicting blood transfusion in patients undergoing surgery for oral and oropharyngeal cancer.
  
  
  METHODS
  We conducted a retrospective cohort study of patients undergoing tumor resection and free flap reconstruction for locally advanced oral and oropharyngeal squamous cell carcinoma between 2000 and 2008. The primary outcome variable was perioperative exposure to allogenic blood transfusion. Univariate and multivariate logistic regression models were used to determine predictors of blood transfusion.
  
  
  RESULTS
  A cohort of 142 participants was found eligible. In a multivariate model, Charlson score ≥ 1 (OR, 5.2; 95% CI, 1.4 to 19.3; P = .01), preoperative hemoglobin levels ≤ 12 g/dl (OR, 4.4; 95% CI, 1.2 to 16.2; P = .03), bone resection (OR, 5.1; 95% CI, 1.5 to 17.8; P = .01), and osseous free tissue transfer (OR, 8.8; 95% CI, 1.0 to 74.8; P = .046) were independently associated with an increased risk of blood transfusion.
  
  
  CONCLUSIONS
  Our study identified patient- and surgery-related factors predicting a higher risk of exposure to allogenic blood transfusion. This readily available preoperative information could be used to better stratify patients according to their transfusion risk and may thereby guide blood conservation strategies in high-risk patients.
authors.affiliation: Department of Cranio-, Maxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria. christos.perisanidis@meduniwien.ac.at
authors.forename: Christos
authors.initials: C
authors.lastname: Perisanidis
authors.forename: Martina
authors.initials: M
authors.lastname: Mittlböck
authors.forename: Markus
authors.initials: M
authors.lastname: Dettke
authors.forename: Christian
authors.initials: C
authors.lastname: Schopper
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schoppmann
authors.forename: George C
authors.initials: GC
authors.lastname: Kostakis
authors.forename: Günter
authors.initials: G
authors.lastname: Russmüller
authors.forename: Anton
authors.initials: A
authors.lastname: Stift
authors.forename: Anastasios
authors.initials: A
authors.lastname: Kanatas
authors.forename: Rudolf
authors.initials: R
authors.lastname: Seemann
authors.forename: Rolf
authors.initials: R
authors.lastname: Ewers
mesh_terms: D000367:Age Factors; D000428:Alcohol Drinking; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D058752:Free Tissue Flaps; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000601:surgery*; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D061646:Operative Time; D009959:Oropharyngeal Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking; D065227:Transfusion Reaction
chemical_list: D006454:Hemoglobins