title: 'Third wave' cognitive therapy versus mentalization-based therapy for major depressive disorder. A protocol for a randomised clinical trial.
abstract: BACKGROUND
  Most interventions for depression have shown small or no effects. 'Third wave' cognitive therapy and mentalization-based therapy have both gained some ground as treatments of psychological problems. No randomised trial has compared the effects of these two interventions for patients with major depression.
  
  
  METHODS
  We plan a randomised, parallel group, assessor-blinded superiority clinical trial. During two years we will include 84 consecutive adult participants diagnosed with major depressive disorder. The participants will be randomised to either 'third wave' cognitive therapy versus mentalization-based therapy. The primary outcome will be the Hamilton Rating Scale for Depression at cessation of treatment at 18 weeks. Secondary outcomes will be the proportion of patients with remission, Symptom Checklist 90 Revised, Beck's Depression Inventory, and The World Health Organisation-Five Well-being Index 1999.
  
  
  CONCLUSIONS
  Interventions for depression have until now shown relatively small effects. Our trial results will provide knowledge about the effects of two modern psychotherapeutic interventions.
  
  
  BACKGROUND
  ClinicalTrials: NCT01070134.
authors.affiliation: Psychiatric Research Unit, Copenhagen University Hospital and Region Zealand, Roskilde, Denmark. janusjakobsen@mac.com
authors.forename: Janus Christian
authors.initials: JC
authors.lastname: Jakobsen
authors.forename: Christian
authors.initials: C
authors.lastname: Gluud
authors.forename: Mickey
authors.initials: M
authors.lastname: Kongerslev
authors.forename: Kirsten Aaskov
authors.initials: KA
authors.lastname: Larsen
authors.forename: Per
authors.initials: P
authors.lastname: Sørensen
authors.forename: Per
authors.initials: P
authors.lastname: Winkel
authors.forename: Theis
authors.initials: T
authors.lastname: Lange
authors.forename: Ulf
authors.initials: U
authors.lastname: Søgaard
authors.forename: Erik
authors.initials: E
authors.lastname: Simonsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002985:Clinical Protocols / Q000592:standards; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003865:Major Depressive Disorder / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012107:Research Design; D016037:Single-Blind Method; D056345:Theory of Mind / Q000502:physiology*; D016896:Treatment Outcome; D055815:Young Adult