title: Does Helicobacter pylori infection increase incidence of dementia? The Personnes Agées QUID Study.
abstract: OBJECTIVE
  To determine whether Helicobacter pylori infection was associated with dementia and risk of developing dementia in a longitudinal population-based cohort of elderly adults living in the community.
  
  
  METHODS
  Prospective community-based cohort study.
  
  
  METHODS
  The population-based Personnes Agées QUID (PAQUID) Study.
  
  
  METHODS
  Six hundred three noninstitutionalized individuals aged 65 and older living in the southwest of France followed from 1989 to 2008.
  
  
  METHODS
  A descriptive and comparative analysis including dementia prevalence, according to H. pylori status (serology), was made at baseline. Cox proportional hazard models were used to study the risk of developing dementia according to H. pylori status assessed on sera samples from elderly adults initially free of dementia and followed for 20 years. A neurologist diagnosed dementia according to Diagnostic and Statistical Manual of Mental Disorders Third Edition criteria.
  
  
  RESULTS
  At baseline, 391 (64.8%) subjects (348 women, mean age 73.9 ± 6.5) were seropositive for H. pylori. Dementia prevalence was higher in the infected group (5.4% vs 1.4%, P = .02). After 20 years of follow-up, 148 incident cases of dementia were diagnosed. After controlling for age, sex, educational level, apolipoprotein E4 status, cardiovascular risk factors, and Mini-Mental State Examination score, H. pylori infection was determined to be a risk factor for developing dementia (hazard ratio = 1.46, P = .04).
  
  
  CONCLUSIONS
  This longitudinal population-based study provides additional epidemiological support to the hypothesis of an association between dementia and H. pylori infection, which may enhance neurodegeneration.
authors.affiliation: INSERM, U853, F-33000, Bordeaux, France. claire.roubaud@chu-bordeaux.fr
authors.forename: Claire
authors.initials: C
authors.lastname: Roubaud Baudron
authors.forename: Luc
authors.initials: L
authors.lastname: Letenneur
authors.forename: Anthony
authors.initials: A
authors.lastname: Langlais
authors.forename: Alice
authors.initials: A
authors.lastname: Buissonnière
authors.forename: Francis
authors.initials: F
authors.lastname: Mégraud
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
authors.forename: Nathalie
authors.initials: N
authors.lastname: Salles
mesh_terms: D000367:Age Factors; D000368:Aged; D003704:Dementia / Q000453:epidemiology* / Q000209:etiology; D018450:Disease Progression; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D013997:Time Factors