title: Familial risk of early and late onset cancer: nationwide prospective cohort study.
abstract: OBJECTIVE
  To determine whether familial risk of cancer is limited to early onset cases.
  
  
  METHODS
  Nationwide prospective cohort study.
  
  
  METHODS
  Nationwide Swedish Family-Cancer Database.
  
  
  METHODS
  All Swedes born after 1931 and their biological parents, totalling >12.2 million individuals, including >1.1 million cases of first primary cancer.
  
  
  METHODS
  Familial risks of the concordant cancers by age at diagnosis.
  
  
  RESULTS
  The highest familial risk was seen for offspring whose parents were diagnosed at an early age. Familial risks were significantly increased for colorectal, lung, breast, prostate, and urinary bladder cancer and melanoma, skin squamous cell carcinoma, and non-Hodgkin's lymphoma, even when parents were diagnosed at age 70-79 or 80-89. When parents were diagnosed at more advanced ages (≥ 90), the risk of concordant cancer in offspring was still significantly increased for skin squamous cell carcinoma (hazard ratio 1.9, 95% confidence interval 1.4 to 2.7), colorectal (1.6, 1.2 to 2.0), breast (1.3, 1.0 to 1.6), and prostate cancer (1.3, 1.1 to 1.6). For offspring with a cancer diagnosed at ages 60-76 whose parents were affected at age <50, familial risks were not significantly increased for nearly all cancers.
  
  
  CONCLUSIONS
  Though the highest familial risks of cancer are seen in offspring whose parents received a diagnosis of a concordant cancer at earlier ages, increased risks exist even in cancers of advanced ages. Familial cancers might not be early onset in people whose family members were affected at older ages and so familial cancers might have distinct early and late onset components.
authors.affiliation: Division of Molecular Genetic Epidemiology, German Cancer Research Centre, 69120 Heidelberg, Germany. E.Kharazmi@dkfz.de
authors.forename: E
authors.initials: E
authors.lastname: Kharazmi
authors.forename: M
authors.initials: M
authors.lastname: Fallah
authors.forename: K
authors.initials: K
authors.lastname: Sundquist
authors.forename: K
authors.initials: K
authors.lastname: Hemminki
mesh_terms: D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology