title: [Present status of research in bone marrow-derived mesenchymal stem cells for promoting the healing of diabetic ulcer].
abstract: The delayed healing of diabetic ulcer has been haunting the surgeons and researchers for a long time. Although we have been researching and exploring the effective therapies for many years, the progress has been limited. Bone marrow-derived mesenchymal stem cells (BMSCs) have gradually won worldwide attention for their characteristics of differentiating into tissue repair cells and secreting multiple cytokines as well as growth factors. In recent years, the role of BMSCs in the treatment of diabetic ulcer has been drawing more and more attention. This article reviewed the advancement in the research of BMSCs in promoting the healing of diabetic ulcer. Through a discussion of the treatment of diabetic ulcer, the related research in BMSCs, as well as its role in diabetic ulcer treatment, the mechanism of BMSCs in promoting healing of diabetic ulcers is discussed. We expect through further research, unified criteria for the quality of BMSCs, application approach and dosage of BMSCs could be established.
authors.affiliation: Center of Plastic Surgery and Burns, 309th Hospital of Chinese PLA, Beijing 100091, China.
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Zheng
authors.forename: Chi-Yu
authors.initials: CY
authors.lastname: Jia
mesh_terms: D001854:Bone Marrow Cells; D048909:Diabetes Complications / Q000628:therapy*; D006801:Humans; D059630:Mesenchymal Stem Cells; D014456:Ulcer / Q000628:therapy*; D014945:Wound Healing