title: The biology/disease-driven human proteome project (B/D-HPP): enabling protein research for the life sciences community.
abstract: The biology and disease oriented branch of the Human Proteome Project (B/D-HPP) was established by the Human Proteome Organization (HUPO) with the main goal of supporting the broad application of state-of the-art measurements of proteins and proteomes by life scientists studying the molecular mechanisms of biological processes and human disease. This will be accomplished through the generation of research and informational resources that will support the routine and definitive measurement of the process or disease relevant proteins. The B/D-HPP is highly complementary to the C-HPP and will provide datasets and biological characterization useful to the C-HPP teams. In this manuscript we describe the goals, the plans, and the current status of the of the B/D-HPP.
authors.affiliation: Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. aebersold@imsb.biol.ethz.ch
authors.forename: Ruedi
authors.initials: R
authors.lastname: Aebersold
authors.forename: Gary D
authors.initials: GD
authors.lastname: Bader
authors.forename: Aled M
authors.initials: AM
authors.lastname: Edwards
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: van Eyk
authors.forename: Martin
authors.initials: M
authors.lastname: Kussmann
authors.forename: Jun
authors.initials: J
authors.lastname: Qin
authors.forename: Gilbert S
authors.initials: GS
authors.lastname: Omenn
mesh_terms: D001690:Biological Science Disciplines; D004194:Disease / Q000145:classification / Q000235:genetics*; D015870:Gene Expression; D015894:Genome, Human; D016045:Human Genome Project; D006801:Humans; D013058:Mass Spectrometry; D020543:Proteome / Q000235:genetics / Q000378:metabolism
chemical_list: D020543:Proteome