title: Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130.
abstract: MicroRNAs (miRNAs) are essential for regulating normal embryonic development and carcinogenesis. Here we report that miR-17-5p, an oncofoetal miRNA, is a key regulator of colorectal cancer progression. We show that miR-17-5p is an oncogenic miRNA that regulates tumorigenesis and progression by targeting the gene encoding P130 and subsequently activating the Wnt/β-catenin pathway. Using specimens from two large cohorts of colorectal cancer patients, we found that patients whose tumours had high miR-17-5p expression had shorter overall survival rates but showed a better response to adjuvant chemotherapy than did patients whose tumours had low miRNA expression. We also observed a strong inverse correlation between miR-17-5p and P130 expression. The current findings suggest that miR-17-5p is a crucial determinant of colorectal cancer progression.
authors.affiliation: Department of General Surgery, Tenth People's Hospital affiliated to Tongji University, 301 Yanchang Road, Shanghai 200072, China.
authors.forename: Yanlei
authors.initials: Y
authors.lastname: Ma
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Huizhen
authors.initials: H
authors.lastname: Zhang
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Yang
authors.forename: Chenzhang
authors.initials: C
authors.lastname: Shi
authors.forename: Yang
authors.initials: Y
authors.lastname: Xia
authors.forename: Jiayuan
authors.initials: J
authors.lastname: Peng
authors.forename: Weijie
authors.initials: W
authors.lastname: Liu
authors.forename: Zhe
authors.initials: Z
authors.lastname: Yang
authors.forename: Huanlong
authors.initials: H
authors.lastname: Qin
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000503:physiopathology; D050719:Crk-Associated Substrate Protein / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D015536:Down-Regulation / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000096:biosynthesis / Q000502:physiology*; D009374:Neoplasms, Experimental / Q000235:genetics / Q000503:physiopathology; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D016019:Survival Analysis; D060449:Wnt Signaling Pathway / Q000502:physiology
chemical_list: D050719:Crk-Associated Substrate Protein; C524941:MIRN17 microRNA, human; D035683:MicroRNAs