title: [Exposure of recurrent pterygium and normal Tenon's capsule fibroblasts to triamcinolone].
abstract: OBJECTIVE
  To evaluate the proliferation rate of recurrent pterygium and normal Tenon's capsule fibroblasts after exposure to triamcinolone.
  
  
  METHODS
  Explants of recurrent pterygia and normal Tenon's capsule of the same carrier were cultured. The fibroblasts were cultured and subcultured until the third passage and subsequently exposed to triamcinolone. The cell proliferation rate was evaluated 3, 6, 12 and 18 days after the exposure.
  
  
  RESULTS
  Fibroblasts exposed to triamcinolone had significantly lower proliferation rate (P <0.05) compared to those not exposed, when the evaluation was performed 3, 6 and 12 days later. In the 18th day after exposure, there was a return in the proliferation rate, with statistical significance, only in the pterygium fibroblasts.
  
  
  CONCLUSIONS
  Both the fibroblasts from normal Tenon's capsule as from recurrent pterygia showed significantly lower proliferation rate after exposure to triamcinolone. After 18 days from the exposition, pterygium fibroblasts recovered the proliferation. The results suggested the triamcinolone might be useful as adjuvant in pterygium treatment.
authors.affiliation: Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista Júlio Mesquita Filho - UNESP - Botucatu (SP), Brasil.
authors.forename: Magda Massae Hata
authors.initials: MM
authors.lastname: Viveiros
authors.forename: Dalton
authors.initials: D
authors.lastname: Kitakawa
authors.forename: Clodomir S C de
authors.initials: CS
authors.lastname: Carvalho
authors.forename: João
authors.initials: J
authors.lastname: Candeias
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Padovani
authors.forename: Silvana Artioli
authors.initials: SA
authors.lastname: Schellini
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D018929:Cell Culture Techniques; D049109:Cell Proliferation / Q000187:drug effects*; D004311:Double-Blind Method; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D011446:Prospective Studies; D011625:Pterygium / Q000473:pathology* / Q000601:surgery; D012008:Recurrence; D058475:Tenon Capsule / Q000166:cytology* / Q000187:drug effects; D013997:Time Factors; D014221:Triamcinolone / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D014221:Triamcinolone