title: One pot solvent free synthesis and in vitro antitubercular screening of 3-Aracylphthalides against Mycobacterium tuberculosis.
abstract: One pot synthesis of 3-Aracylphthalide was accomplished in good yield by reacting 2-carboxy benzaldehyde with various aromatic methyl ketones in presence of methane sulphonic acid. Various phthalides thus obtained were characterized with spectral techniques. These phthalides were subjected to in vitro antitubercular screening against Mycobacterium tuberculosis H37Ra (MTB) by using XRMA protocol. Among the phthalides screened, four exhibited half maximal inhibitory concentration (IC(50)) in the range of 0.81-1.24 μg/ml thereby providing potential lead compounds for future drug discovery studies.
authors.affiliation: Post Graduate & Research Centre, Department of Chemistry, MES Abasaheb Garware College, Pune, India.
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Limaye
authors.forename: Virendra B
authors.initials: VB
authors.lastname: Kumbhar
authors.forename: Arun D
authors.initials: AD
authors.lastname: Natu
authors.forename: Madhusudan V
authors.initials: MV
authors.lastname: Paradkar
authors.forename: Varsha S
authors.initials: VS
authors.lastname: Honmore
authors.forename: Rubia R
authors.initials: RR
authors.lastname: Chauhan
authors.forename: Suwarna P
authors.initials: SP
authors.lastname: Gample
authors.forename: Dhiman
authors.initials: D
authors.lastname: Sarkar
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D012997:Solvents
chemical_list: D000995:Antitubercular Agents; D001572:Benzofurans; D012997:Solvents