title: The association between gender and outcome of patients with upper tract urothelial cancer.
abstract: The incidence of upper tract urothelial cancer (UTUC) has gradually increased over the past 30 years. Although most reports have shown that UTUC occurs more frequently in men than in women, women have been found to have a worse prognosis than men. In Taiwan, a high incidence of UTUC has been reported, with an unusual minor predominance of female cases. The purpose of this study was to determine the influence of gender on the outcome of patients with UTUC after nephroureterectomy and bladder cuff excision. From January 1990 to December 2007, 301 patients diagnosed with UTUC were admitted at our institution. A retrospective analysis of the effect of gender on the clinical outcome was performed. We compared the 5-year bladder recurrence-free, progression-free, and disease-specific survival rates. While we did not observe any differences between men and women in bladder recurrence-free, progression-free, or disease-specific survival rates, we found that female patients had a significantly higher percentage of contralateral recurrence than the males (5.9% vs. 0.8%, p = 0.019).
authors.affiliation: Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Yii-Her
authors.initials: YH
authors.lastname: Chou
authors.forename: Wei-Chiao
authors.initials: WC
authors.lastname: Chang
authors.forename: Wen-Jeng
authors.initials: WJ
authors.lastname: Wu
authors.forename: Ching-Chia
authors.initials: CC
authors.lastname: Li
authors.forename: Hsin-Chih
authors.initials: HC
authors.lastname: Yeh
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Hou
authors.forename: Ping-Song
authors.initials: PS
authors.lastname: Chou
authors.forename: Mei-Hui
authors.initials: MH
authors.lastname: Lee
authors.forename: Wei-Pin
authors.initials: WP
authors.lastname: Chang
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D012737:Sex Factors; D013624:Taiwan; D014513:Ureter / Q000473:pathology / Q000601:surgery*; D001743:Urinary Bladder / Q000473:pathology / Q000601:surgery*; D014571:Urologic Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery