title: Concurrent pulmonary Aspergillus fumigatus and mucor infection in a cardiac transplant recipient: a case report.
abstract: Invasive fungal infections are a significant complication of solid organ transplantation. Here we report the first case of concurrent invasive pulmonary fungal infection caused by Aspergillus fumigatus and Mucor species in a heart transplant recipient. Polymicrobial mold infection is rare but should be considered in solid organ transplant recipients who fail to respond to initial antifungal therapy targeting a single organism. It is also of interest that in addition to potent immunosuppression and prolonged voriconazole therapy, possible airway fungal colonization following hurricane Katrina cleaning efforts might have contributed to this dual invasive mold infection.
authors.affiliation: Department of Internal Medicine, Mayo Clinic, Scottsdale, Arizona 85054, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Webb
authors.forename: J E
authors.initials: JE
authors.lastname: Blair
authors.forename: S
authors.initials: S
authors.lastname: Kusne
authors.forename: R L
authors.initials: RL
authors.lastname: Scott
authors.forename: D E
authors.initials: DE
authors.lastname: Steidley
authors.forename: F A
authors.initials: FA
authors.lastname: Arabia
authors.forename: H R
authors.initials: HR
authors.lastname: Vikram
mesh_terms: D000391:Air Microbiology; D000935:Antifungal Agents / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000601:surgery*; D055867:Cyclonic Storms; D004781:Environmental Exposure; D016027:Heart Transplantation / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D055744:Invasive Pulmonary Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D011743:Pyrimidines / Q000627:therapeutic use; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole