title: Chromogenic and fluorogenic sensing of biological thiols in aqueous solutions using BODIPY-based reagents.
abstract: Judicious design of BODIPY dyes carrying nitroethenyl substituents in conjugation with the BODIPY core yields dyes that respond to biological thiols by both absorbance and emission changes. Incorporation of solubilizing ethyleneglycol units ensures water solubility. The result is bright signaling of biologically relevant thiols in the longer wavelength region of the visible spectrum and in aqueous solutions.
authors.affiliation: UNAM-National Nanotechnology Research Center, Bilkent University, 06800 Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Isik
authors.forename: Tugba
authors.initials: T
authors.lastname: Ozdemir
authors.forename: Ilke Simsek
authors.initials: IS
authors.lastname: Turan
authors.forename: Safacan
authors.initials: S
authors.lastname: Kolemen
authors.forename: Engin U
authors.initials: EU
authors.lastname: Akkaya
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D012996:Solutions; D013438:Sulfhydryl Compounds / Q000032:analysis*; D014867:Water / Q000737:chemistry
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D012996:Solutions; D013438:Sulfhydryl Compounds; D014867:Water