title: Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA.
abstract: There is increasing interest in the use of edited proton magnetic resonance spectroscopy for the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a number of spectroscopy groups met to discuss the acquisition, analysis and interpretation of GABA-edited MR spectra. This paper aims to set out the issues discussed at this meeting, reporting areas of consensus around parameters and procedures in the field and highlighting those areas where differences remain. It is hoped that this paper can fulfill two needs, providing a summary of the current 'state-of-the-art' in the field of GABA-edited MRS at 3T using MEGA-PRESS and a basic guide to help researchers new to the field to avoid some of the pitfalls inherent in the acquisition and processing of edited MRS for GABA.
authors.affiliation: Bangor Imaging Unit, School of Psychology, Bangor University, Bangor, LL57 2AS, UK. Electronic address: p.mullins@bangor.ac.uk.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Mullins
authors.affiliation: CUBRIC, School of Psychology, Cardiff University, Cardiff, CF10 3AT, UK; School of Biosciences, Cardiff University, Cardiff, CF10 3AT, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: McGonigle
authors.affiliation: University Children's Hospital, Steinwiesstrasse 75, 8032 Zürich, Switzerland; Center for Integrative Human Physiology (ZIHP), University of Zürich, Switzerland.
authors.forename: Ruth L
authors.initials: RL
authors.lastname: O'Gorman
authors.affiliation: Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA; F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 North Broadway Street, Room G-25, Baltimore, MD 21205, USA.
authors.forename: Nicolaas A J
authors.initials: NA
authors.lastname: Puts
authors.affiliation: Biomedical Imaging Institute, School of Cancer and Enabling Sciences, Manchester University, Stopford Building, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Rishma
authors.initials: R
authors.lastname: Vidyasagar
authors.affiliation: CUBRIC, School of Psychology, Cardiff University, Cardiff, CF10 3AT, UK.
authors.forename: C John
authors.initials: CJ
authors.lastname: Evans
authors.affiliation: Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA; F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 North Broadway Street, Room G-25, Baltimore, MD 21205, USA.
authors.forename: Richard A E
authors.initials: RA
authors.lastname: Edden
mesh_terms: D000465:Algorithms; D001921:Brain / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid