title: HLA-G 3' untranslated region 14-base pair deletion: association with poor survival in an HIV-1-infected Zimbabwean population.
abstract: We aimed to evaluate whether the HLA-G 14-base pair (bp) polymorphism (rs16375) has an impact on human immunodeficiency virus HIV progression and survival in an antiretroviral therapy-naive Zimbabwean cohort (n = 312). Rs16375 was genotyped using a competitive allele-specific polymerase chain reaction system; CD4 cell counts and HIV RNA were measured with flow cytometry and commercially available polymerase chain reaction; survival was followed up for 4.3 years. The homozygous HLA-G -14-bp genotype is associated with higher viral load (P = .004), lower CD4 cell count (P = .01), and increased mortality (hazard ratio, 1.9; 95% confidence interval, 1.033-3.522; P = .04) compared with HLA-G +14-bp carriers.
authors.affiliation: Department of Clinical Immunology, Copenhagen University Hospital Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark. margit.h.larsen@rh.regionh.dk
authors.forename: Margit Hørup
authors.initials: MH
authors.lastname: Larsen
authors.forename: Rutendo
authors.initials: R
authors.lastname: Zinyama
authors.forename: Per
authors.initials: P
authors.lastname: Kallestrup
authors.forename: Jan
authors.initials: J
authors.lastname: Gerstoft
authors.forename: Exnevia
authors.initials: E
authors.lastname: Gomo
authors.forename: Lise Wegner
authors.initials: LW
authors.lastname: Thørner
authors.forename: Trine Baldorf
authors.initials: TB
authors.lastname: Berg
authors.forename: Christian
authors.initials: C
authors.lastname: Erikstrup
authors.forename: Henrik
authors.initials: H
authors.lastname: Ullum
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000328:Adult; D001483:Base Sequence; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology*; D059951:HLA-G Antigens / Q000235:genetics*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D011110:Polymorphism, Genetic; D016016:Proportional Hazards Models; D012367:RNA, Viral / Q000097:blood*; D012424:Rural Population; D017384:Sequence Deletion; D015996:Survival Rate; D019562:Viral Load; D015030:Zimbabwe
chemical_list: D020413:3' Untranslated Regions; D059951:HLA-G Antigens; D012367:RNA, Viral