title: The polymorphisms of the MBL2 and MIF genes associated with Pediatric Cochlear Implant Patients.
abstract: OBJECTIVE
  Mannose-binding lectin and macrophage migration inhibitory factor gene polymorphisms are associated with several acute/chronic autoimmune or inflammatory diseases. The aim of this study was to investigate if there was any association between mannose-binding lectin 2 (MBL2) and macrophage migration inhibitory factor (MIF) gene polymorphisms and profound congenital sensorineural hearing loss in children who underwent cochlear implantation.
  
  
  METHODS
  A total of 62 patients with congenital hearing loss and 80 age- and sex-matched healthy controls were evaluated for codon 54 A/B polymorphisms in MBL2 and the-173 G/C polymorphism in MIF by using the polymerase chain reaction and restriction fragment length polymorphism method.
  
  
  RESULTS
  The frequency of the BB genotype of MBL2 and MIF -173 GC genotype were statistically significantly higher in the patient group than in the controls (p=0.0127, p=0.0408, respectively).
  
  
  CONCLUSIONS
  In this study, we found that a subject who is homozygous for the variant allele B of codon 54 of the MBL2and heterozygous for variant allele C of -173 MIF has a risk factor for sensorineural hearing loss.
authors.affiliation: Gaziantep University, Faculty of Medicine, Department of Otolaryngology, 27060. Sahinbey, Gaziantep, Turkey. baysalelif@yahoo.com
authors.forename: Elif
authors.initials: E
authors.lastname: Baysal
authors.forename: Sibel
authors.initials: S
authors.lastname: Oguzkan-Balci
authors.forename: Orhan
authors.initials: O
authors.lastname: Tunc
authors.forename: Fatih
authors.initials: F
authors.lastname: Celenk
authors.forename: Murat
authors.initials: M
authors.lastname: Deniz
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Kanlikama
authors.forename: Merve
authors.initials: M
authors.lastname: Kahraman
authors.forename: Sacide
authors.initials: S
authors.lastname: Pehlivan
mesh_terms: D002648:Child; D002675:Child, Preschool; D003054:Cochlear Implants; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D006801:Humans; D007223:Infant; D019746:Intramolecular Oxidoreductases / Q000235:genetics*; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics*; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C445619:MBL2 protein, human; D008263:Macrophage Migration-Inhibitory Factors; D037601:Mannose-Binding Lectin; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human