title: Cell-based vasculogenic studies in preclinical models of chronic myocardial ischaemia and hibernation.
abstract: BACKGROUND
  Coronary artery disease commonly leads to myocardial ischaemia and hibernation. Relevant preclinical models of these conditions are essential to evaluate new therapeutic options such as cell-based vasculogenic therapies.
  
  
  METHODS
  In this article, the authors first review basic concepts of myocardial ischaemia/hibernation and relevant techniques to assess myocardial viability. Then, preclinical models of chronic myocardial ischaemia and hibernation, induced by devices such as ameroid constrictors, Delrin stenosis, hydraulic occluders, and coils/stents are described. Lastly, the authors discuss cell-based vasculogenic therapy, and summarise studies conducted in large animal models of chronic myocardial ischaemia and hibernation.
  
  
  CONCLUSIONS
  Approximately one-third of patients with viable myocardium do not undergo revascularisation; however, this population is at high risk for cardiac events and would surely benefit from effective cell-based therapy. Because of the modest benefits in clinical studies, preclinical models accurately representing clinical myocardial ischemia/hibernation are necessary to better understand and appropriately direct regenerative therapy research.
authors.affiliation: University of Ottawa Heart Institute, Division of Cardiac Surgery, 40 Ruskin Street, Suite 3403, Ottawa, Ontario, K1Y 4W7, Canada.
authors.forename: Céline
authors.initials: C
authors.lastname: Giordano
authors.forename: Drew
authors.initials: D
authors.lastname: Kuraitis
authors.forename: Rob S B
authors.initials: RS
authors.lastname: Beanlands
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Suuronen
authors.forename: Marc
authors.initials: M
authors.lastname: Ruel
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D006801:Humans; D017202:Myocardial Ischemia / Q000473:pathology*; D017682:Myocardial Stunning / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology*