title: Expression of CXCR4 is an independent prognostic factor for overall survival and progression-free survival in patients with myelodysplastic syndrome.
abstract: CXCR4 is the receptor of stromal cell-derived factor (SDF-1) and is expressed in many types of cancer cells. It also plays an important role in metastasis of malignant disease. In this study, we detected the expression of CXCR4 in 81 patients with myelodysplastic syndrome (MDS) by flow cytometry. We categorized MDS patients into the high-expression group and low-expression group according to CXCR4 mean florescence intensity ration thresholds. We showed that the high-expression group had a shorter overall survival time and shorter relapse-free survival time compared with those of the low-expression group (21.6 ± 1.9 vs. 46.0 ± 1.6 months, 17.0 ± 1.9 vs. 42.5 ± 2.1 months, respectively, P < 0.05), and Cox regression showed that CXCR4 was an independent prognostic factor. We conclude that the expression of CXCR4 is a useful prognostic factor for patients with MDS.
authors.affiliation: Department of Hematology, Tianjin Cancer Hospital and Institute, Tianjin Medical University, Tianjin 300060, People's Republic of China. yizhuozhang111@163.com
authors.forename: Yizhuo
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Guo
authors.forename: Haifeng
authors.initials: H
authors.lastname: Zhao
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhao
authors.forename: Xiaoxiong
authors.initials: X
authors.lastname: Wu
authors.forename: Weipeng
authors.initials: W
authors.lastname: Zhao
authors.forename: Yafei
authors.initials: Y
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Xia
authors.forename: Wanming
authors.initials: W
authors.lastname: Da
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000378:metabolism* / Q000401:mortality*; D011379:Prognosis; D016016:Proportional Hazards Models; D019718:Receptors, CXCR4 / Q000032:analysis / Q000096:biosynthesis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; C527276:CXCR4 protein, human; D019718:Receptors, CXCR4