title: Aluminum may mediate Alzheimer's disease through liver toxicity, with aberrant hepatic synthesis of ceruloplasmin and ATPase7B, the resultant excess free copper causing brain oxidation, beta-amyloid aggregation and Alzheimer disease.
authors.forename: Steven
authors.initials: S
authors.lastname: Brenner
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000535:Aluminum / Q000633:toxicity*; D000544:Alzheimer Disease / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002570:Ceruloplasmin / Q000096:biosynthesis*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008962:Models, Theoretical; D010084:Oxidation-Reduction
chemical_list: D016229:Amyloid beta-Peptides; D000535:Aluminum; D002570:Ceruloplasmin; D000251:Adenosine Triphosphatases