title: [Teratogenicity of 3, 4 two furazan-based oxidation furazan in rats].
abstract: OBJECTIVE
  To study the teratogenicity of new high-energy compounds, 3, 4 two furazan-based oxidation furazan (DNTF) and the impact on human health, occupational exposure limits were provided for the following research.
  
  
  METHODS
  Pregnant SD rats were randomly divided into five groups by Standard teratogenicity test, including three dose groups (5.0, 15.8, 50.0 mg/kg), the negative control (vegetable oil), and the positive control group (CP 10.0 mg/kg). Each 10 to 15 rats were in one group. Gavage was consecutive for rats during pregnancy 7 ∼ 12 d and then sacrifice after 20 d.
  
  
  RESULTS
  There were no significantly difference between the three dose groups and negative controls in the pregnancy rate, the weight of pregnant rats, fetal weight, fetal growth, fetal malformation rate and internal organs,
  
  
  CONCLUSIONS
  There were no maternal toxicity, embryo toxicity and teratogenicity for rats when DNTF in the range 5.0 ∼ 50.0 mg/kg.
authors.affiliation: 521 Institute of China North Industries Group, Xi'an 710065, China.
authors.forename: Yu-ling
authors.initials: YL
authors.lastname: Wang
authors.forename: Wen-xia
authors.initials: WX
authors.lastname: DU
authors.forename: Yuan-han
authors.initials: YH
authors.lastname: Sun
authors.forename: Feng
authors.initials: F
authors.lastname: Xie
authors.forename: Ya-fei
authors.initials: YF
authors.lastname: Xing
authors.forename: Yu
authors.initials: Y
authors.lastname: Qing
authors.forename: Jiang-ping
authors.initials: JP
authors.lastname: Li
mesh_terms: D000818:Animals; D005260:Female; D009583:Nitrofurazone / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013723:Teratogens
chemical_list: D013723:Teratogens; D009583:Nitrofurazone