title: An optimal control problem arising from a dengue disease transmission model.
abstract: An optimal control problem for a host-vector Dengue transmission model is discussed here. In the model, treatments with mosquito repellent are given to adults and children and those who undergo treatment are classified in treated compartments. With this classification, the model consists of 11 dynamic equations. The basic reproductive ratio that represents the epidemic indicator is obtained from the largest eigenvalue of the next generation matrix. The optimal control problem is designed with four control parameters, namely the treatment rates for children and adult compartments, and the drop-out rates from both compartments. The cost functional accounts for the total number of the infected persons, the cost of the treatment, and the cost related to reducing the drop-out rates. Numerical results for the optimal controls and the related dynamics are shown for the case of epidemic prevention and outbreak reduction strategies.
authors.affiliation: Department of Mathematics, Institut Teknologi Bandung, Bandung 40132, Indonesia.
authors.forename: Dipo
authors.initials: D
authors.lastname: Aldila
authors.forename: Thomas
authors.initials: T
authors.lastname: Götz
authors.forename: Edy
authors.initials: E
authors.lastname: Soewono
mesh_terms: D000328:Adult; D000330:Aedes / Q000821:virology*; D000465:Algorithms; D000818:Animals; D050936:Basic Reproduction Number; D002648:Child; D003715:Dengue / Q000191:economics / Q000453:epidemiology* / Q000517:prevention & control* / Q000635:transmission; D003716:Dengue Virus / Q000502:physiology*; D004196:Disease Outbreaks; D006801:Humans; D007303:Insect Vectors / Q000821:virology*; D008954:Models, Biological; D009032:Mosquito Control / Q000191:economics; D009716:Numerical Analysis, Computer-Assisted