title: Acute indoramin poisoning: a review of 55 cases reported to the Paris Poison Centre from 1986 t o 2010.
abstract: Authors report a retrospective study of all cases of indoramin-only poisoning notified to the Paris poison Centre from 1986 to 2010. Fifty five cases of indoramin self-poisoning were included: 40 adults and 15 children. The mean supposed ingested dose was about 701 mg±464 mg. ECG showed a prolonged QTc interval (equal to or greater than 0.50 s) in 30% of patients. The lowest observed dose for prolonged QTc was 625 mg. This series includes two cases of seizures occurring around two hours after ingestion of 900 and 2 250 mg of indoramin. A review of the literature showed cardiac disorders, with a delayed mechanism of action up until 18 hours after ingestion. Therefore, rapid medical resuscitation and prolonged cardiac monitoring for at least 24 hours after ingestion of 625 mg are recommended.
authors.affiliation: Hopital Fernand Widal, Paris, France. antoine.villa@lrb.aphp.fr
authors.forename: Antoine F
authors.initials: AF
authors.lastname: Villa
authors.forename: Huan
authors.initials: H
authors.lastname: Tran Hong
authors.forename: Hwee Min
authors.initials: HM
authors.lastname: Lee
authors.forename: Dominique
authors.initials: D
authors.lastname: Chataigner
authors.forename: Robert
authors.initials: R
authors.lastname: Garnier
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000506:poisoning; D002648:Child; D002675:Child, Preschool; D062787:Drug Overdose / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007217:Indoramin / Q000506:poisoning*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010297:Paris / Q000453:epidemiology; D011039:Poison Control Centers / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents; D007217:Indoramin