title: [Peculiarity of the laboratory diagnostic of the measles virus infection in previously vaccinated and unvaccinated patients].
abstract: 119 specimens of blood sera collected from measles cases with different vaccination history (aged 4 months to 48 years) on 5th-6th days after rash onset were Investigated using EIA. The obtained results showed that the primary immune response (PIR) was developed in 59 patients; the secondary immune response (SIR) was developed in 60 patients with a significant increase in the specific high avidity IgG (22.34 IU/ml +/- 3.2). The specific IgM were detected in 100% cases studied with capture ELISA in both previously vaccinated and unvaccinated individuals of different age. The specific IgM were detected by indirect ELISA in 100% cases in unvaccinated patients, while IgM positive sera was defined only in 23.3% of individuals with SIR. It was concluded that measles virus infection in previously vaccinated and unvaccinated adults had clinical differences. The role of patients with SIR in virus transmission was discussed.
authors.forename: T A
authors.initials: TA
authors.lastname: Mamaeva
authors.forename: G Iu
authors.initials: GIu
authors.lastname: Lipskaia
authors.forename: M A
authors.initials: MA
authors.lastname: Naumova
authors.forename: S V
authors.initials: SV
authors.lastname: Shul'ga
authors.forename: M
authors.initials: M
authors.lastname: Mulders
authors.forename: D A
authors.initials: DA
authors.lastname: Featherstone
authors.forename: L A
authors.initials: LA
authors.lastname: Zav'ialova
authors.forename: E V
authors.initials: EV
authors.lastname: Chernysheva
authors.forename: E P
authors.initials: EP
authors.lastname: Zamiatina
authors.forename: N N
authors.initials: NN
authors.lastname: Kuznetsova
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007223:Infant; D008457:Measles / Q000097:blood / Q000276:immunology; D008458:Measles Vaccine / Q000276:immunology; D008459:Measles virus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D008875:Middle Aged; D014611:Vaccination
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008458:Measles Vaccine