title: Evidence for the analgesic activity of resveratrol in acute models of nociception in mice.
abstract: The effects of trans-resveratrol (1) were evaluated in acute nociception models induced by capsaicin or glutamate in mice, in an attempt to further characterize its mechanism of action. The oral administration of 1 (50 and 100 mg/kg) reduced significantly the licking behavior elicited by capsaicin (1.6 μg/paw) or glutamate (10 μmol/paw). The co-administration of 1 into the mouse paw (200 μg/site) markedly prevented glutamate-induced licking, without affecting capsaicin responses. In addition, the intrathecal (it) injection of 1 (150 to 600 μg/site) greatly reduced the licking behavior caused by capsaicin, but not glutamate. Similarly, the intracerebroventricular injection of 1 (300 μg/site) caused a potent inhibition of capsaicin-induced nociception, while the glutamate responses remained unaffected. However, the co-administration of 1 (300 μg/site) reduced the biting behavior induced by spinal injection of glutamate (30 μg/site, it), leaving capsaicin (6.4 μg/site)-induced biting unaltered. Notably, the oral administration of 1 (100 mg/kg) inhibited significantly the capsaicin-induced increase of c-Fos and COX-2 labeling in the spinal cord and COX-2 expression in the cortex, but failed to affect c-Fos and COX-2 expression in the glutamate model. This study has explored the effects of 1 in both the capsaicin and glutamate models, extending current knowledge on the analgesic effects of trans-resveratrol.
authors.affiliation: Postgraduate Program in Medicine and Health Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Karen O
authors.initials: KO
authors.lastname: Bazzo
authors.forename: André A
authors.initials: AA
authors.lastname: Souto
authors.forename: Tiago G
authors.initials: TG
authors.lastname: Lopes
authors.forename: Rafael F
authors.initials: RF
authors.lastname: Zanin
authors.forename: Marcus V
authors.initials: MV
authors.lastname: Gomez
authors.forename: Alessandra H
authors.initials: AH
authors.lastname: Souza
authors.forename: Maria M
authors.initials: MM
authors.lastname: Campos
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology; D051546:Cyclooxygenase 2 / Q000032:analysis / Q000235:genetics; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D015394:Molecular Structure; D059225:Nociception / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000235:genetics; D000077185:Resveratrol; D013237:Stereoisomerism; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D016760:Proto-Oncogene Proteins c-fos; D013267:Stilbenes; D018698:Glutamic Acid; D051546:Cyclooxygenase 2; D000077185:Resveratrol; D002211:Capsaicin