title: Single voxel in vivo proton magnetic resonance spectroscopy of breast lesions: experience in 77 cases.
abstract: OBJECTIVE
  We aimed to determine the value of in vivo single voxel proton magnetic resonance spectroscopy (MRS) in characterizing breast lesions.
  
  
  METHODS
  Breast MRS was performed in 77 patients. Choline resonance peak at 3.2 parts per million (ppm) was defined positive when it was at least two times higher than baseline. MRS findings were compared with the final diagnosis of cases for two different values (3.23 and 3.28 ppm).
  
  
  RESULTS
  Thirty-one malignant and 13 benign lesions had choline peaks. Sensitivity was 84%, specificity was 64%. Positive likelihood ratio (LHR) was 2.32, negative LHR was 0.25. Twenty-two malignant and 5 benign lesions had a peak at 3.23 ppm. Nine malignant and 8 benign lesions had a peak at 3.28 ppm. When 3.23 ppm was accepted as positive; sensitivity, specificity, and positive and negative LHRs were 79%, 82%, 4.4, and 0.26, respectively.
  
  
  CONCLUSIONS
  MRS provides additional parameters on evaluation of breast lesions. However, MRS of breast has some false negative results, thus it is still insufficient in clinical diagnosis.
authors.affiliation: Department of Radiology, Celal Bayar University School of Medicine, Manisa, Turkey. slbasara@yahoo.com
authors.forename: Işıl
authors.initials: I
authors.lastname: Başara
authors.forename: Şebnem
authors.initials: Ş
authors.lastname: Örgüç
authors.forename: Teoman
authors.initials: T
authors.lastname: Coşkun
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002794:Choline; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D002794:Choline