title: Synthesis of perylene bisimide-centered glycodendrimer and its interactions with concanavalin A.
abstract: A novel glycodendrimer based on 18 peripheral α-D-mannoses functionalized perylene bisimide derivative PBI-18-Man was synthesized and its selectively binding interactions for Con A were investigated by CD spectra and turbidity assay, which exhibited strong binding affinity for Con A with the binding constant of 1.3×10(8) M(-1) (7.2×10(6) M(-1) for monomeric mannose, valency corrected), 3 orders of magnitude higher affinity than the monovalent mannose ligand. Furthermore, the inhibitory activity for Con A was studied by ELLA experiment, showed 2 times inhibitor activity than the reference compound (α-MMP).
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, PR China. kerangwang@hbu.edu.cn
authors.forename: Ke-Rang
authors.initials: KR
authors.lastname: Wang
authors.forename: Yue-Qing
authors.initials: YQ
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: An
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhang
authors.forename: Jin-Chao
authors.initials: JC
authors.lastname: Zhang
authors.forename: Xiao-Liu
authors.initials: XL
authors.lastname: Li
mesh_terms: D001681:Biological Assay; D002942:Circular Dichroism; D003208:Concanavalin A / Q000737:chemistry / Q000378:metabolism*; D050091:Dendrimers; D007094:Imides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D010569:Perylene / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding
chemical_list: D050091:Dendrimers; D007094:Imides; C581679:PBI-18-Man; C510697:perylene bisimide; D003208:Concanavalin A; D010569:Perylene