title: [Testosterone-deficiency as a risk factor for hip fracture in eldery men].
abstract: OBJECTIVE
  Progressive loss of bone mineral density weakens the bones and increases the probability of osteoporotic fractures. It is well known that sex steroids play a role in the maintenance of bone density. This fact makes us think there might be a correlation between sex steroid levels and osteoporotic hip fractures.
  
  
  METHODS
  A case-control study was performed. The cases were 54 men who suffered from hip fracture. They were compared with 54 age-matched male control subjects. Levels of total testosterone, sex hormone binding globuline, albumin and oestradiol were measured in all subjects in order to calculate free testosterone and bio-testosterone levels.
  
  
  RESULTS
  Men who suffered from hip fracture had lower serum total testosterone (8.74 nmol/L versus 11.16 nmol/L; p=0.116) and lower free testostenone (155.1pmol/L versus 204.4pmol/L; p=0.02) than control subjects. Bio-testosterone levels were lower in patients with hip fracture (2.69 nmol/L versus 3.89 nmol/L; p=0.002), being the latter the best fracture predictor (OR: 1.58).
  
  
  CONCLUSIONS
  In our study population, men with hip fractures had significantly lower levels of calculated free testosterone and bio-testosterone. These findings suggest that free testosterone and bio-testosterone levels are independent predictors for osteoporotic hip fracture in eldery men.
authors.affiliation: Servicio de Urología, Hospital Universitario de Bellvitge, Barcelona, España. jtorremade@hotmail.com
authors.forename: J
authors.initials: J
authors.lastname: Torremadé-Barreda
authors.forename: J
authors.initials: J
authors.lastname: Rodríguez-Tolrà
authors.forename: I
authors.initials: I
authors.lastname: Román-Romera
authors.forename: A
authors.initials: A
authors.lastname: Padró-Miquel
authors.forename: J
authors.initials: J
authors.lastname: Rius-Moreno
authors.forename: E
authors.initials: E
authors.lastname: Franco-Miranda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D006620:Hip Fractures / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D058866:Osteoporotic Fractures / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D013739:Testosterone / Q000172:deficiency*
chemical_list: D013739:Testosterone