title: [The clinical influence of double or multiple primary cancers on the prognosis of patients with gastric cancer].
abstract: BACKGROUND
  An aging population and advances in diagnostic technology have led to an increase in the incidence of double or multiple primary cancers(DMPC) in patients with gastric cancer(GC). This study was designed to evaluate the clinical influence of DMPC on the prognosis of patients with GC.
  
  
  METHODS
  Between 1997 and 2009, 1,086 patients underwent curative gastrectomy for GC in our hospital.
  
  
  RESULTS
  1) 1,086 patients were analyzed, and of these 166 patients (15%) had DMPC and the remaining 920 patients had no DMPC. GC patients with DMPC had a significantly higher age (p <0.0001) and higher incidence of differentiated cancer(p=0.0045) than those without DMPC. 2) Multivariate analysis showed the presence of DMPC was an independent prognostic factor for overall survival. It was particularly noteworthy that the prognosis of GC patients with hematological cancer, hepato-biliary pancreatic cancer and esophageal cancer was extremely poor. In contrast, those with colorectal cancer and urological cancer had a comparatively better prognosis. The number of DMPC had little influence on the prognosis of GC patients. 3) In a survival associated with GC, the presence of DMPC had no influence on the prognosis of GC patients.
  
  
  CONCLUSIONS
  The types of DMPC had more clinical influence on the prognosis of GC patients than the number of DMPC with respect to overall survival.
authors.affiliation: Dept. of Surgery, Kyoto Prefectural University of Medicine, Japan.
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Shuhei
authors.initials: S
authors.lastname: Komatsu
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ichikawa
authors.forename: Kazuma
authors.initials: K
authors.lastname: Okamoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shiozaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Murayama
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kuriu
authors.forename: Hisashi
authors.initials: H
authors.lastname: Ikoma
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Toshiya
authors.initials: T
authors.lastname: Ochiai
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Kokuba
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000401:mortality*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality*