title: A 14-membered macrolide and isocoumarin derivatives from the cultured lichen mycobionts of Graphis vestitoides.
abstract: Spore-derived mycobionts of the crustose lichen Graphis vestitoides collected in Vietnam were cultivated on a malt-yeast extract medium supplemented with 10% sucrose. The investigation of their metabolites resulted in isolation of a novel 14-membered macrolide and a new isocoumarin, together with five known isocoumarin derivatives. Their structures were determined by spectroscopic and chemical means. This is the first instance of isolation of a 14-membered macrolide from a lichen mycobiont.
authors.affiliation: Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan.
authors.forename: Duy Hoang
authors.initials: DH
authors.lastname: Le
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Takenaka
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hamada
authors.forename: Hiromi
authors.initials: H
authors.lastname: Miyawaki
authors.forename: Takao
authors.initials: T
authors.lastname: Tanahashi
mesh_terms: D049934:Isocoumarins / Q000737:chemistry*; D008011:Lichens / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods; D014744:Vietnam
chemical_list: D049934:Isocoumarins; D018942:Macrolides