title: Protective effect of cyanidin 3-O-glucoside on beta-amyloid peptide-induced cognitive impairment in rats.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder that results in cognitive impairment. It has been proposed that deposits of beta-amyloid (Aβ) form the cores of the plaque and, subsequently, induce the activation of GSK-3β and the hyperphosphorylation of tau, resulting in cognitive impairment. Oxidative stress has been proposed to be an important factor in the pathogenesis of AD. Cyanidin 3-O-glucoside (Cy3G) is a neuroprotective antioxidant. However, the effects of Cy3G on cognition are unclear. In this paper, we show that Cy3G is protective against the Aβ-induced impairment of learning and memory, but has no effect on normal learning and memory. Moreover, we found that Gy3G attenuated the Aβ-induced tau hyperphosphorylation and GSK-3β hyperactivation observed in AD. Taken together, these results demonstrated that Cy3G can rescue the cognitive impairments that are induced by Aβ via the modulation of GSK-3β/tau, suggesting a potential therapeutic role of Cy3G in AD.
authors.affiliation: Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. qinlina1978@126.com
authors.forename: Lina
authors.initials: L
authors.lastname: Qin
authors.forename: Jianlong
authors.initials: J
authors.lastname: Zhang
authors.forename: Mali
authors.initials: M
authors.lastname: Qin
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D003072:Cognition Disorders / Q000517:prevention & control*; D005960:Glucosides / Q000494:pharmacology* / Q000627:therapeutic use; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D010446:Peptide Fragments / Q000378:metabolism* / Q000633:toxicity; D010766:Phosphorylation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D000872:Anthocyanins; D000975:Antioxidants; D005960:Glucosides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); C462279:cyanidin-3-O-beta-glucopyranoside; D016875:tau Proteins; D000071679:Glycogen Synthase Kinase 3 beta; C000605508:Gsk3b protein, rat; D038362:Glycogen Synthase Kinase 3