title: Effect of plastoquinone derivative 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) on estrous cycle and 17β-estradiol level in rats.
abstract: Administration of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to female Wistar rats with regular estrous cycle once a day for two weeks at doses of 25 nmol/kg (but not 250 nmol/kg) leads to increase in proestrus duration by reducing the phase of diestrus and metestrus. Neither dose caused significant changes in serum 17β-estradiol level for any stage of the cycle. However, relative elongation of the proestrus stage leads to an increase in average per cycle estradiol levels by 20%.
authors.affiliation: Research Institute of Biology of Southern Federal University, pr. Stachki 194/1, 344090 Rostov-on-Don, Russia. vladimirchi@yandex.ru
authors.forename: V A
authors.initials: VA
authors.lastname: Chistyakov
authors.forename: S V
authors.initials: SV
authors.lastname: Dem'yanenko
authors.forename: A A
authors.initials: AA
authors.lastname: Alexandrova
authors.forename: L V
authors.initials: LV
authors.lastname: Gutnikova
authors.forename: V N
authors.initials: VN
authors.lastname: Prokof'ev
authors.forename: O N
authors.initials: ON
authors.lastname: Kosheleva
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood*; D030762:Estrous Cycle / Q000187:drug effects*; D005260:Female; D010971:Plastoquinone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: C532038:10-(6'-plastoquinonyl)decyltriphenylphosphonium; D004958:Estradiol; D010971:Plastoquinone