title: Investigation of Zr(IV) and 89Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging.
abstract: Single crystal X-ray diffraction shows that Zr(iv) forms an octa-coordinated complex with 4 bidentate hydroxamates whose solution structures were investigated by utilizing density functional theory at the level of B3LYP/DGDZVP. Stability constants obtained by potentiometry were in accordance with the tendency observed when radiolabeling with (89)Zr.
authors.affiliation: Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, NCI, NIH, Bethesda, Maryland 20892, USA.
authors.forename: François
authors.initials: F
authors.lastname: Guérard
authors.forename: Yong-Sok
authors.initials: YS
authors.lastname: Lee
authors.forename: Raphaël
authors.initials: R
authors.lastname: Tripier
authors.forename: Lawrence P
authors.initials: LP
authors.lastname: Szajek
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Deschamps
authors.forename: Martin W
authors.initials: MW
authors.lastname: Brechbiel
mesh_terms: D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003676:Deferoxamine / Q000737:chemistry; D006877:Hydroxamic Acids / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D049268:Positron-Emission Tomography; D011789:Quantum Theory; D011868:Radioisotopes / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D056831:Coordination Complexes; D006877:Hydroxamic Acids; D011868:Radioisotopes; D015040:Zirconium; D003676:Deferoxamine