title: Outbreak of multidrug-resistant CTX-M-15-producing Enterobacter cloacae in a neonatal intensive care unit.
abstract: Newborns are rarely infected by extended-spectrum β-lactamase (ESBL)-producing members of the Enterobacteriaceae. In a neonatal intensive care unit, 14 newborns were infected or colonized by CTX-M-15-producing Enterobacter cloacae. All seven infected patients had underlying medical conditions, and five of them were treated successfully with meropenem, whilst one untreated patient died. Paediatric infections caused by multidrug-resistant ESBL-producing Enterobacter cloacae constitute a critical clinical and epidemiological issue.
authors.affiliation: Antibiotic Laboratory, Department of Bacteriology, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Oteo
authors.affiliation: Department of Medicine, Universidad Complutense, Madrid, Spain.|Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Emilia
authors.initials: E
authors.lastname: Cercenado
authors.affiliation: Antibiotic Laboratory, Department of Bacteriology, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Vindel
authors.affiliation: Antibiotic Laboratory, Department of Bacteriology, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Bautista
authors.affiliation: Antibiotic Laboratory, Department of Bacteriology, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Fernández-Romero
authors.affiliation: Antibiotic Laboratory, Department of Bacteriology, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Saéz
authors.affiliation: Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Padilla
authors.affiliation: Neonatal Intensive Care Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Zamora
authors.affiliation: Consejo Superior de Investigaciones Científicas, Madrid, Spain.|Antibiotic Laboratory, Department of Bacteriology, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Campos
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D016000:Cluster Analysis; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D058889:Molecular Typing; D013845:Thienamycins / Q000627:therapeutic use; D016896:Treatment Outcome; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases; D000077731:Meropenem