title: Chemical constituents from Andrographis echioides and their anti-inflammatory activity.
abstract: Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds,  (1-2) and (6-19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan. tswu@mail.ncku.edu.tw.
authors.forename: De-Yang
authors.initials: DY
authors.lastname: Shen
authors.forename: Shin-Hun
authors.initials: SH
authors.lastname: Juang
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: Guan-Jhong
authors.initials: GJ
authors.lastname: Huang
authors.forename: Yu-Yi
authors.initials: YY
authors.lastname: Chan
authors.forename: Amooru G
authors.initials: AG
authors.lastname: Damu
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002853:Chromatography, Liquid; D044950:Flavanones / Q000494:pharmacology; D047309:Flavones / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000473:pathology; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D066244:Proton Magnetic Resonance Spectroscopy; D053719:Tandem Mass Spectrometry
chemical_list: D000893:Anti-Inflammatory Agents; D044950:Flavanones; D047309:Flavones; D008070:Lipopolysaccharides; D009569:Nitric Oxide