title: Angled- or straight-tipped hydrophilic guidewire in biliary cannulation: a prospective, randomized, controlled trial.
abstract: BACKGROUND
  Deep biliary cannulation is the key for successful endoscopic retrograde cholangiopancreatography (ERCP) procedures. Guidewire-assisted cannulation is associated both with a higher success rate and a reduced risk of post-ERCP pancreatitis compared with standard catheter cannulation. However, to our knowledge there are no prospective, randomized studies comparing the use of different guidewires in biliary cannulation. The goal of this study was to compare the performance of an angled-tipped guidewire (AGW) with a straight-tipped guidewire (SGW) in achieving successful deep biliary cannulation.
  
  
  METHODS
  Patients with intended biliary cannulation of an intact papilla were prospectively randomized to angled- or straight-tipped hydrophilic guidewire arms in a tertiary, referral, university hospital setting. Randomized cannulation method was applied either until successful cannulation of the bile duct or until 2 min had passed. Crossover was not included in the study protocol. The main outcome measurements were the cannulation success rate and duration of cannulation.
  
  
  RESULTS
  Of the 239 consecutive patients, 155 patients were randomized: in the final analysis 70 patients were included in the AGW arm and 83 patients in the SGW arm. Cannulation time [median; seconds (s)] was shorter with the AGW compared with the SGW (20 vs. 63 s, p = 0.01). There was no difference in the cannulation success rate or the complication rate between the two study groups.
  
  
  CONCLUSIONS
  AGW may facilitate biliary cannulation in ERCP.
authors.affiliation: Department of Surgery, Turku University Hospital, Kiinamyllynkatu 4-8, 20521, Turku, Finland. hanna.vihervaara@tyks.fi
authors.forename: Hanna
authors.initials: H
authors.lastname: Vihervaara
authors.forename: Juha M
authors.initials: JM
authors.lastname: Grönroos
authors.forename: Mari
authors.initials: M
authors.lastname: Koivisto
authors.forename: Risto
authors.initials: R
authors.lastname: Gullichsen
authors.forename: Paulina
authors.initials: P
authors.lastname: Salminen
mesh_terms: D000368:Aged; D001652:Bile Ducts; D002404:Catheterization / Q000295:instrumentation*; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies