title: Treatment of Rickettsia spp. infections: a review.
abstract: Human rickettsioses caused by intracellular bacteria of the genus Rickettsia are distributed worldwide and are transmitted by arthropod vectors such as ticks, fleas, mites and lice. They have a wide range of manifestations from benign to life-threatening diseases. Mortality rates of up to 30% have been reported for some rickettsioses. Here, the authors will review in vitro and human studies of the various compounds that have been used for the treatment of Rickettsia spp. infections. The authors will also provide recommendations for the treatment of spotted fever and typhus group rickettsioses.
authors.affiliation: Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, Aix-Marseille Université, UMR CNRS 7278, IRD 198, INSERM U1095, Faculté de Médecine, Marseille, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Botelho-Nevers
authors.forename: Cristina
authors.initials: C
authors.lastname: Socolovschi
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
authors.forename: Philippe
authors.initials: P
authors.lastname: Parola
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004318:Doxycycline / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D016239:MEDLINE; D012281:Rickettsia; D012282:Rickettsia Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D017282:Tick-Borne Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D016896:Treatment Outcome; D014437:Typhus, Endemic Flea-Borne / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D014438:Typhus, Epidemic Louse-Borne / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline