title: Ironic case of hepatic dysfunction following the global withdrawal of sitaxentan.
abstract: A patient with pulmonary arterial hypertension secondary to systemic sclerosis was successfully treated with sitaxentan prior to its worldwide withdrawal (because of hepatotoxicity concerns), but then ironically experienced acute hepatic dysfunction during substitute bosentan therapy, and was eventually stabilised on a phosphodiesterase-5 inhibitor.
authors.affiliation: Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia.
authors.forename: G W
authors.initials: GW
authors.lastname: Don
authors.forename: F
authors.initials: F
authors.lastname: Joseph
authors.forename: D S
authors.initials: DS
authors.lastname: Celermajer
authors.forename: T J
authors.initials: TJ
authors.lastname: Corte
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects; D000077300:Bosentan; D065128:Endothelin Receptor Antagonists; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D007555:Isoxazoles / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008875:Middle Aged; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use; D011687:Purines / Q000627:therapeutic use; D056737:Safety-Based Drug Withdrawals; D012595:Scleroderma, Systemic / Q000150:complications; D000068677:Sildenafil Citrate; D013449:Sulfonamides / Q000009:adverse effects; D013450:Sulfones / Q000627:therapeutic use; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D065128:Endothelin Receptor Antagonists; D007555:Isoxazoles; D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D013449:Sulfonamides; D013450:Sulfones; D013876:Thiophenes; D000068677:Sildenafil Citrate; C106276:sitaxsentan; D000077300:Bosentan