title: Severe falciparum malaria with dengue coinfection complicated by rhabdomyolysis and acute kidney injury: an unusual case with myoglobinemia, myoglobinuria but normal serum creatine kinase.
abstract: BACKGROUND
  Acute kidney injury (AKI) is a complication of severe malaria, and rhabdomyolysis with myoglobinuria is an uncommon cause. We report an unusual case of severe falciparum malaria with dengue coinfection complicated by AKI due to myoglobinemia and myoglobinuria while maintaining a normal creatine kinase (CK).
  
  
  METHODS
  A 49-year old Indonesian man presented with fever, chills, and rigors with generalized myalgia and was diagnosed with falciparum malaria based on a positive blood smear. This was complicated by rhabdomyolysis with raised serum and urine myoglobin but normal CK. Despite rapid clearance of the parasitemia with intravenous artesunate and aggressive hydration maintaining good urine output, his myoglobinuria and acidosis worsened, progressing to uremia requiring renal replacement therapy. High-flux hemodiafiltration effectively cleared his serum and urine myoglobin with recovery of renal function. Further evaluation revealed evidence of dengue coinfection and past infection with murine typhus.
  
  
  CONCLUSIONS
  In patients with severe falciparum malaria, the absence of raised CK alone does not exclude a diagnosis of rhabdomyolysis. Raised serum and urine myoglobin levels could lead to AKI and should be monitored. In the event of myoglobin-induced AKI requiring dialysis, clinicians may consider using high-flux hemodiafiltration instead of conventional hemodialysis for more effective myoglobin removal. In Southeast Asia, potential endemic coinfections that can also cause or worsen rhabdomyolysis, such as dengue, rickettsiosis and leptospirosis, should be considered.
authors.affiliation: Department of Infectious Diseases, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore.
authors.forename: Kok Pin
authors.initials: KP
authors.lastname: Yong
authors.forename: Ban Hock
authors.initials: BH
authors.lastname: Tan
authors.forename: Chian Yong
authors.initials: CY
authors.lastname: Low
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000175:diagnosis / Q000652:urine*; D060085:Coinfection / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D003402:Creatine Kinase / Q000097:blood / Q000652:urine; D003715:Dengue / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood; D009212:Myoglobinuria / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D012206:Rhabdomyolysis / Q000097:blood / Q000175:diagnosis* / Q000652:urine
chemical_list: D009211:Myoglobin; D003402:Creatine Kinase