title: 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care.
abstract: This report is of a round-table discussion held in Cardiff in September 2009 for Cesagen, a research centre within the Genomics Network of the UK's Economic and Social Research Council. The meeting was arranged to explore ideas as to the likely future course of human genomics. The achievements of genomics research were reviewed, and the likely constraints on the pace of future progress were explored. New knowledge is transforming biology and our understanding of evolution and human disease. The difficulties we face now concern the interpretation rather than the generation of new sequence data. Our understanding of gene-environment interaction is held back by our current primitive tools for measuring environmental factors, and in addition, there may be fundamental constraints on what can be known about these complex interactions.
authors.affiliation: Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, Wales CF14 4XN, UK. clarkeaj@cardiff.ac.uk
authors.forename: Angus J
authors.initials: AJ
authors.lastname: Clarke
authors.forename: David N
authors.initials: DN
authors.lastname: Cooper
authors.forename: Michael
authors.initials: M
authors.lastname: Krawczak
authors.forename: Chris
authors.initials: C
authors.lastname: Tyler-Smith
authors.forename: Helen M
authors.initials: HM
authors.lastname: Wallace
authors.forename: Andrew O M
authors.initials: AO
authors.lastname: Wilkie
authors.forename: Frances Lucy
authors.initials: FL
authors.lastname: Raymond
authors.forename: Ruth
authors.initials: R
authors.lastname: Chadwick
authors.forename: Nick
authors.initials: N
authors.lastname: Craddock
authors.forename: Ros
authors.initials: R
authors.lastname: John
authors.forename: John
authors.initials: J
authors.lastname: Gallacher
authors.forename: Mathias
authors.initials: M
authors.lastname: Chiano
mesh_terms: D002874:Chromosome Mapping; D057890:Epigenomics / Q000379:methods*; D059647:Gene-Environment Interaction; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005826:Genetics, Medical / Q000379:methods*; D015894:Genome, Human; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D010597:Pharmacogenetics; D010641:Phenotype; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA