title: Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L.
abstract: Five new triterpenoid saponins, named as sibiricasaponins A-E (1-5), were isolated and identified from the aerial parts of Polygala sibirica L., together with nine known triterpenoid saponins (6-14). The chemical structures of the five new triterpenoid saponins (1-5) were elucidated as 3β,19α-dihydroxyurso-12-ene-23,28-dioic acid 3-O-β-d-glucuronopyranoside (1), pomolic acid 3-O-(3-O-sulfo)-α-l-arabinopyranoside (2), pomolic acid 3-O-(4-O-sulfo)-β-d-xylopyranoside (3), pomolic acid 3-O-(2-O-acetyl-3-O-sulfo)-α-l-arabinopyranoside (4), and 3-O-β-d-glucopyranosyl medicagenic acid 28-O-β-d-galactopyranosyl (1→4)-β-d-xylopyranosyl (1→4)-α-l-rhamnopyranosyl (1→2)-(4-O-acetyl)-[β-d-apiofuranosyl (1→3)]-β-d-fucopyranosyl ester (5), respectively, on the basis of spectroscopic data and physicochemical evidences. These isolated compounds (1-14) were evaluated for their anti-ischemic effects on oxygen/glucose deprivation (OGD) model in vitro, and only compound 7 showed a weak anti-ischemia effect, with EC(50) value of 46.7μM.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors.forename: Yue-Lin
authors.initials: YL
authors.lastname: Song
authors.forename: Ke-Wu
authors.initials: KW
authors.lastname: Zeng
authors.forename: Tian-Xing
authors.initials: TX
authors.lastname: Shi
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Tu
mesh_terms: D000818:Animals; D002470:Cell Survival; D005947:Glucose / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism; D015394:Molecular Structure; D010100:Oxygen / Q000378:metabolism; D016716:PC12 Cells; D035261:Plant Components, Aerial / Q000737:chemistry*; D031801:Polygala / Q000737:chemistry*; D051381:Rats; D012503:Saponins / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D012503:Saponins; D014315:Triterpenes; D005947:Glucose; D010100:Oxygen