title: [The chemiluminescent detection of activity in peripheral blood neutrophils under allergic diseases of lungs in children with fungous sensibilization].
abstract: The high mobilization activity of neutrophils as a capacity of momentary feed-back reaction to factually any external stimuli, make it possible to use them in various diagnostic systems in vitro. Among them is the automated test system of chemiluminescent detection of functional activity of peripheral blood neutrophils in parallel response to luminol, opsonizing zymosan and different antigens. This approach makes it possible to evaluate the initial and induced activity of phagocytes and its dynamics in case of adding in vitro to test system of one or another allergen. The application of micro technique of chemiluminescent detection of functional activity of peripheral blood neutrophils revealed the stimulating effect of allergens Aaspergillus fumigatus, Alternaria alternata, Cladosporum herbatum, Candida albicans and Penicillinum notatum. This is an additional evidence of high sensitivity of children with allergic diseases of lungs to fungi and hence one more factor of diagnostics and treatment.
authors.forename: A V
authors.initials: AV
authors.lastname: Semenova
authors.forename: T A
authors.initials: TA
authors.lastname: Minenkova
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Mizernitskiĭ
mesh_terms: D000485:Allergens / Q000276:immunology / Q000302:isolation & purification; D001228:Aspergillosis / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D001249:Asthma / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D005658:Fungi / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D008163:Luminescent Measurements; D008165:Luminol / Q000494:pharmacology; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D010586:Phagocytes / Q000276:immunology / Q000378:metabolism; D015054:Zymosan / Q000494:pharmacology
chemical_list: D000485:Allergens; D007073:Immunoglobulin E; D008165:Luminol; D015054:Zymosan