title: Platelet-function testing in patients undergoing neurovascular procedures: caught between a rock and a hard place.
abstract: In the context of neurointerventional procedures, clopidogrel hyper-responsiveness has been associated with hemorrhage; on the other hand, clopidogrel resistance has been associated with thromboembolism. This might seem to make a compelling argument in favor of routine platelet testing. Our reading of the literature leads us to conclude that routine platelet testing in neurointerventional procedures is not, unfortunately, ready for prime time.
authors.affiliation: St Vincent’s Hospital Melbourne, Fitzroy, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Comin
authors.forename: D F
authors.initials: DF
authors.lastname: Kallmes
mesh_terms: D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology*; D000077144:Clopidogrel; D004351:Drug Resistance; D057510:Endovascular Procedures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects*; D015607:Stents / Q000009:adverse effects*; D013923:Thromboembolism / Q000209:etiology*; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine