title: Mechanisms of diabetic dyslipidemia: relevance for atherogenesis.
abstract: Diabetic dyslipidemia is due to a multiple array of metabolic abnormalities determining a typical phenotype characterized by increased plasma triglycerides, reduced HDL and a preponderance of small, dense LDL. This dyslipidemia, defined as atherogenic dyslipidemia, is thought to be highly responsible for the increased cardiovascular risk in diabetes mellitus. Several lines of evidence indicate that the increased liver production of VLDL is the main underlying defect in atherogenic dyslipidemia. This review will recapitulate the pathophysiological aspects of diabetic dyslipidemia with special focus on the molecular mechanism causing increased liver production of VLDL in diabetic patients. The consequences of atherogenic dyslipidemia on mechanisms of atherogenesis will be also reviewed.
authors.affiliation: Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma Viale del Policlinico, 155- 00161 Rome, Italy. marcelloarca@libero.it
authors.forename: Marcello
authors.initials: M
authors.lastname: Arca
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pigna
authors.forename: Carla
authors.initials: C
authors.lastname: Favoccia
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D050171:Dyslipidemias / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008099:Liver / Q000378:metabolism*; D011379:Prognosis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides