title: Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation.
abstract: The cullin-RING ubiquitin ligase, CRL1(SKP2), directing the degradation of the tumor suppressor p27, is a well validated drug target in a wide variety of human cancers. In this issue of Chemistry & Biology, Wu and colleagues describe first-in-class small molecule inhibitors of CRL1(SKP2)-mediated degradation of p27.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Rico-Bautista
authors.forename: Dieter A
authors.initials: DA
authors.lastname: Wolf