title: Recent advances in olfactory receptor-based biosensors.
abstract: The biological olfactory system can recognize and discriminate thousands of volatile organic compounds (VOCs) with extremely high sensitivity and specificity. The most fundamental elements are olfactory receptors (ORs) in the cilia of olfactory sensory neurons (OSNs), which contribute greatly to the high-performance olfactory system. The excellent properties of ORs are generally recognized in the development of biomimetic OR-based biosensors. Over the past two decades, much work has been done in developing OR-based biosensors due to their promising potential in many applications. In this article, we will outline the latest advances of OR-based biosensors. Two current crucial issues in this field will be discussed, namely, the production methods and immobilization techniques of ORs. We will also elaborate on various OR-based biosensors and their latest developments. Finally, current research trends and future challenges in this field will be discussed.
authors.affiliation: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Du
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Wu
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Liu
authors.forename: Liquan
authors.initials: L
authors.lastname: Huang
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D002923:Cilia / Q000502:physiology; D006801:Humans; D009475:Neurons, Afferent / Q000737:chemistry / Q000502:physiology; D018034:Olfactory Receptor Neurons / Q000737:chemistry / Q000502:physiology; D018035:Receptors, Odorant / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D012680:Sensitivity and Specificity; D012903:Smell
chemical_list: D018035:Receptors, Odorant