title: Digestive tract neural control and gastrointestinal disorders in cerebral palsy.
abstract: OBJECTIVE
  To examine the neural control of digestive tract and describe the main gastrointestinal disorders in cerebral palsy (CP), with attention to the importance of early diagnosis to an efficient interdisciplinary treatment.
  
  
  METHODS
  Systematic review of literature from 1997 to 2012 from Medline, Lilacs, Scielo, and Cochrane Library databases. The study included 70 papers, such as relevant reviews, observational studies, controlled trials, and prevalence studies. Qualitative studies were excluded. The keywords used were: cerebral palsy, dysphagia, gastroesophageal reflux disease, constipation, recurrent respiratory infections, and gastrostomy.
  
  
  RESULTS
  The appropriate control of the digestive system depends on the healthy functioning and integrity of the neural system. Since CP patients have structural abnormalities of the central and peripheral nervous system, they are more likely to develop eating disorders. These range from neurological immaturity to interference in the mood and capacity of caregivers. The disease has, therefore, a multifactorial etiology. The most prevalent digestive tract disorders are dysphagia, gastroesophageal reflux disease, and constipation, with consequent recurrent respiratory infections and deleterious impact on nutritional status.
  
  
  CONCLUSIONS
  Patients with CP can have neurological abnormalities of digestive system control; therefore, digestive problems are common. The issues raised in the present study are essential for professionals within the interdisciplinary teams that treat patients with CP, concerning the importance of comprehensive anamnesis and clinical examination, such as detailed investigation of gastrointestinal disorders. Early detection of these digestive problems may lead to more efficient rehabilitation measures in order to improve patients' quality of life.
authors.affiliation: Programa de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Salvador, BA, Brazil. lregazzoni@neuromodulationlab.org
authors.forename: Liubiana A
authors.initials: LA
authors.lastname: Araújo
authors.forename: Luciana R
authors.initials: LR
authors.lastname: Silva
authors.forename: Fabiana A A
authors.initials: FA
authors.lastname: Mendes
mesh_terms: D017028:Caregivers; D002547:Cerebral Palsy / Q000150:complications / Q000503:physiopathology*; D003248:Constipation / Q000209:etiology / Q000503:physiopathology; D003680:Deglutition Disorders / Q000209:etiology / Q000503:physiopathology; D001068:Feeding and Eating Disorders / Q000209:etiology / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000503:physiopathology; D005767:Gastrointestinal Diseases / Q000503:physiopathology*; D006801:Humans; D009748:Nutrition Disorders / Q000209:etiology / Q000503:physiopathology; D010348:Patient Care Team; D011788:Quality of Life