title: Clinical outcomes of urothelial carcinoma of the prostate detected in radical cystectomy specimens.
abstract: BACKGROUND
  To evaluate the clinical outcomes of urothelial carcinoma of the prostate (UCP).
  
  
  METHODS
  This retrospective study included a total of 46 patients with UCP detected in radical cystectomy specimens from 1990 to 2006. All patients were stratified by patterns for extension of UC from the bladder and invasion of the prostatic stroma. The overall survival rates of patients were determined by pathological variables of radical cystectomy specimens.
  
  
  RESULTS
  Of the 46 patients with UCP, 34 (74 %) and 12 (26 %) had prostatic stromal and no stromal involvement, respectively. Of 34 patients with UC having prostatic stromal involvement, 22 had contiguous involvement from bladder cancer. Twenty-four patients (52.1 %) had non-contiguous UCP, and of these, 12 (50 %) had UC of the prostatic stroma. UCP patients with prostatic stromal invasion showed a significantly worse prognosis than those without stromal invasion (P = 0.0108). There was no significant difference in survival between patients with contiguous and non-contiguous involvement (P = 0.0877). Patients with non-contiguous UCP (prostatic urethral cancer) showed poor prognosis if the UC invaded into the prostatic stroma and lymph node metastasis was present. Multivariate analysis revealed that these 2 variables were factors that significantly affected the clinical outcome of these patients.
  
  
  CONCLUSIONS
  Patients having UCP with stromal invasion of the prostatic urethra showed much worse prognosis than those without stromal invasion regardless of extension patterns from UC of the bladder. In prostatic urethral cancer, prostatic stromal invasion and lymph node metastasis were significant prognostic factors.
authors.affiliation: Department of Urology, Sapporo Medical University School of Medicine, S1, W16, Chuo-ku, Sapporo, 060-8543, Japan, kichi@sapmed.ac.jp.
authors.forename: Koji
authors.initials: K
authors.lastname: Ichihara
authors.forename: Naoya
authors.initials: N
authors.lastname: Masumori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kitamura
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Taiji
authors.initials: T
authors.lastname: Tsukamoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015653:Cystectomy; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014523:Urethral Neoplasms / Q000473:pathology / Q000601:surgery*; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*