title: Docosahexaenoic acid and phosphatidylserine improves the antioxidant activities in vitro and in vivo and cognitive functions of the developing brain.
abstract: Fish oil during early postnatal period may modulate the impact of oxidative stress in the developing brain and thus improve memory and cognitive behaviour. This study investigated the impacts of docosahexaenoic acid (DHA, C22:6, n-3) and/or phosphatidylserine (PS) on antioxidant activities in vitro, and the beneficial effects of feeding with DHA and/or PS on antioxidant activities in brain and liver tissues and on the cognitive functions of the developing brain. Results indicated that DHA and/or PS significantly enhanced antioxidant activities and increased cell viabilities in vitro. Feeding with DHA and/or PS supplementation not only significantly improved escape latency of animals, but it also improved the oxidative parameters in the brain, enhanced glutathione peroxidase activity as well as reduced nitric mono-oxide levels in the liver. DHA and PS may serve to protect cells from oxidative stress and further improve learning and memory ability in vivo.
authors.affiliation: Department of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan. hcchaung@mail.npust.edu.tw
authors.forename: Hso-Chi
authors.initials: HC
authors.lastname: Chaung
authors.forename: Chin-Dong
authors.initials: CD
authors.lastname: Chang
authors.forename: Pi-Hang
authors.initials: PH
authors.lastname: Chen
authors.forename: Chia-Jung
authors.initials: CJ
authors.lastname: Chang
authors.forename: Shyh-Hwa
authors.initials: SH
authors.lastname: Liu
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Chen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D002460:Cell Line; D003071:Cognition / Q000187:drug effects*; D019587:Dietary Supplements / Q000032:analysis; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D010718:Phosphatidylserines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D005395:Fish Oils; D010718:Phosphatidylserines; D004281:Docosahexaenoic Acids