title: Occlusal disharmony leads to learning deficits associated with decreased cellular proliferation in the hippocampal dentate gyrus of SAMP8 mice.
abstract: Occlusal disharmony is associated with increased plasma corticosterone levels, learning deficits, and morphologic alterations in the hippocampus via chronic stress. Here, we investigated the occlusal disharmony-induced impairment of hippocampal function. We first examined the effects of raising the bite on newborn cell proliferation in the hippocampal dentate gyrus (DG) in senescence-accelerated prone mice. Raising the bite significantly decreased cell proliferation in the hippocampal DG in an age-dependent manner. Immediately after raising the bite, cell proliferation decreased abruptly in the aged mice, then gradually increased, but did not recover to control levels within 2wk. Further, learning-induced cell proliferation was impaired in aged bite-raised mice. These findings suggest that occlusal disharmony induced by raising the bite impaired cell proliferation in the hippocampal DG, leading to learning deficits.
authors.affiliation: Department of Prosthodontics, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Mori
authors.forename: Tasuku
authors.initials: T
authors.lastname: Katayama
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Miyake
authors.forename: Shuu
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Kin-Ya
authors.initials: KY
authors.lastname: Kubo
mesh_terms: D000375:Aging; D000818:Animals; D049109:Cell Proliferation; D018891:Dentate Gyrus / Q000166:cytology*; D007858:Learning; D008297:Male; D018782:Maze Learning; D008568:Memory; D051379:Mice; D014716:Vertical Dimension