title: Survival pattern and prognostic factors of patients with squamous cell carcinoma of the tongue: a retrospective analysis of 210 cases.
abstract: OBJECTIVE
  The aim of this article was to retrospectively analyze squamous cell carcinoma (SCC) of the tongue to determine the tumor characteristics, treatment, and prognostic factors that may influence the survival of patients with this disease.
  
  
  METHODS
  A total number of 210 patients with SCC of the tongue, who were treated at the First Teaching Hospital of Xinjiang Medical University from January 1997 to December 2007, were retrospectively analyzed to calculate the survival rates and determine the predictors of survival. Tumor characteristics and treatment patterns were investigated for locoregional recurrence, as well as the 3- and 5-year overall and disease-specific survival after primary treatment.
  
  
  RESULTS
  Patients who had undergone only the operation had a longer survival than those who had undergone the operation and radiotherapy or had been treated using RT/CRT alone (OR = 3.5, 95% CI = 1.1 to 11.3, P = .033). The 5-year overall survival, disease-specific survival, and locoregional relapse free survival rates were 44.4%, 47.7%, and 40.0%, respectively. Cox's multivariate analyses showed that the tumor invasion depth, perineural invasion, resection margin, treatment, and clinical stages were independent prognostic factors for 5-year survival (P < .05).
  
  
  CONCLUSIONS
  Deep invasion (>9 mm) was the predominant independent prognostic factor for locoregional control and survival after the diagnosis of oral tongue SCC. To achieve higher survival rates, surgery should be considered, even for advanced tongue cancer patients with deep tumor invasion depth.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.
authors.forename: Wang
authors.initials: W
authors.lastname: Ling
authors.forename: Ainiwaer
authors.initials: A
authors.lastname: Mijiti
authors.forename: Adili
authors.initials: A
authors.lastname: Moming
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002681:China / Q000453:epidemiology; D003390:Cranial Nerve Neoplasms / Q000556:secondary; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D055815:Young Adult