title: PIN1-842G/C and -667T/C polymorphisms are not associated with the susceptibility of Alzheimer's disease: pooled analysis of epidemiologic studies.
abstract: Associations between PIN1 gene polymorphisms and Alzheimer's disease (AD) risk remain controversial, possibly because single studies often lack sufficient statistical power. In this study, we performed a meta-analysis to evaluate the association of two commonly studied PIN1 polymorphisms, -842G/C and -667T/C, with the risk of AD. Relevant studies were identified from PubMed, EMBASE, and China National Knowledge Infrastructure up to October 2012. Data were available from a total of 7 case-control studies with 2504 cases and 2322 controls. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to investigate the strength of the association. The results showed no significant association between PIN1-842G/C polymorphism and AD risk in all comparison models (GG vs. GC: OR=0.84, 95%CI=0.61-1.18; GG vs. CC: OR=0.70, 95%CI=0.35-1.41; GC vs. CC: OR=0.81, 95%CI=0.39-1.69; G vs. C: OR=0.89, 95%CI=0.69-1.17; GG vs. GC+CC: OR=0.81, 95%CI=0.56-1.17; GG+GC vs. CC: OR=0.72, 95%CI=0.36-1.45). For the PIN1-667T/C polymorphism, lack of an association was also found. Subgroup analyses by the ethnicity and patients with late-onset AD did not change the results. Conclusively, the present meta-analysis revealed that PIN1 gene polymorphisms (-842G/C and -667T/C) were unlikely to contribute to AD susceptibility.
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cao
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Hai
authors.initials: H
authors.lastname: Ge
authors.forename: Peng-Chao
authors.initials: PC
authors.lastname: Wu
authors.forename: Ping
authors.initials: P
authors.lastname: Qu
authors.forename: Gui-Hai
authors.initials: GH
authors.lastname: Chen
authors.forename: Zong-Liang
authors.initials: ZL
authors.lastname: Gao
mesh_terms: D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide