title: Mesenchymal stem-like cells isolated from human esophageal carcinoma and adjacent non-cancerous tissues.
abstract: Mesenchymal stem cells (MSCs) or MSC-like cells have now been isolated from various sites, including different types of tumor tissues. Whether MSCs or MSC-like cells in different tumor tissues possess differentiated biological characteristics remains unclear, and the correlation between MSCs or MSC-like cells and tumors has been a controversial topic. In the present study, we isolated MSC-like cells from human esophageal carcinoma (hEC-MSCs) and adjacent non-cancerous tissues (hECN-MSCs). Although the two types of MSC-like cells were in different microenvironments and had certain differences, they possessed similar morphological properties and surface antigens, including CD13, CD29, CD44 and CD105. Our results indicated that hEC-MSCs and hECN-MSCs are similar in a number of ways. This may have implications for further research on the esophageal carcinoma microenvironment and its pathological mechanism.
authors.affiliation: School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013;
authors.forename: Jiabo
authors.initials: J
authors.lastname: Hu
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Zhou
authors.forename: Shunbin
authors.initials: S
authors.lastname: Shi
authors.forename: Xiaozhong
authors.initials: X
authors.lastname: Zhu
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Sanqiang
authors.initials: S
authors.lastname: Hu
authors.forename: Hui
authors.initials: H
authors.lastname: Qian
authors.forename: Wenrong
authors.initials: W
authors.lastname: Xu