title: Fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate cancers from northern China.
abstract: In this study we evaluated the frequency of fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate cancers in patients from northern China in order to explore differences in fusion rates among regions in northern and southern China, other parts of Asia, Europe, and North America. We examined 100 prostate cancer patients, diagnosed by means of prostate biopsy; fluorescence in situ hybridization (FISH) was used to detect the expression of TMPRSS2, ERG, ETV1 and ETV4 in cancer tissue. Differences in gene fusion rates among different ethnics groups were also analyzed. Of the 100 prostate cancer patients, 55 (55%) had the fusion gene. Among the patients with the fusion gene, 46 (83.6%) patients had the TMPRSS2:ERG fusion product, 8 (14.8%) patients had TMPRSS2:ETV1 fusion, 1 (1.6%) patient had TMPRSS2:ETV4.
authors.affiliation: Department of Urology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Jian-Jiang
authors.initials: JJ
authors.lastname: Wang
authors.forename: Yue-Xin
authors.initials: YX
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.forename: Yu-Peng
authors.initials: YP
authors.lastname: Zheng
authors.forename: Lu-Dong
authors.initials: LD
authors.lastname: Qiao
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Shan
authors.initials: S
authors.lastname: Chen
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D002681:China; D050939:Gene Fusion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D015514:Oncogene Proteins, Fusion; C515553:TMPRSS2-ERG fusion protein, human; C529661:TMPRSS2-ETV1 fusion protein, human; C529662:TMPRSS2-ETV4 fusion protein, human