title: Lack of replication of seven pancreatic cancer susceptibility loci identified in two Asian populations.
abstract: BACKGROUND
  Two recent genome-wide association studies (GWAS) of pancreatic ductal adenocarcinoma (PDAC), conducted, respectively, in a Japanese and in a Chinese population, identified eight novel loci affecting PDAC risk.
  
  
  METHODS
  We attempted to replicate the novel loci in a series of PDACs and healthy controls of European ancestry in the context of the newly formed PANcreatic Disease ReseArch (PANDoRA) consortium. We genotyped seven single-nucleotide polymorphisms (SNP): rs12413624, rs1547374, rs372883, rs5768709, rs6464375, rs708224, rs9502893 (one SNP identified in the Chinese GWAS is not polymorphic in Caucasians) in 1,299 PDAC cases and 2,884 controls. We also attempted stratified analysis considering the different stages of the disease and addressed the possible involvement of the selected SNPs on the survival of patients.
  
  
  RESULTS
  None of the SNPs were significantly associated with PDAC risk if considering the overall population of the consortium. When stratifying for country of origin, we found that in the Polish subgroup, the G allele of rs372883 was statistically significantly associated with increased risk [OR, 6.40; 95% confidence interval (CI), 2.28-17.91]. However, the sample size of the subgroups was rather small; therefore, this result can be due to chance. None of the SNPs was associated with disease progression or survival.
  
  
  CONCLUSIONS
  None of the SNPs associated with PDAC risk in two Asian populations were convincingly associated with PDAC risk in individuals of European descent.
  
  
  CONCLUSIONS
  This study illustrates the importance of evaluation of PDAC risk markers across ethnic groups.
authors.affiliation: German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Daniele
authors.initials: D
authors.lastname: Campa
authors.forename: Cosmeri
authors.initials: C
authors.lastname: Rizzato
authors.forename: Andrea S
authors.initials: AS
authors.lastname: Bauer
authors.forename: Jens
authors.initials: J
authors.lastname: Werner
authors.forename: Gabriele
authors.initials: G
authors.lastname: Capurso
authors.forename: Eithne
authors.initials: E
authors.lastname: Costello
authors.forename: Renata
authors.initials: R
authors.lastname: Talar-Wojnarowska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Jamroziak
authors.forename: Raffaele
authors.initials: R
authors.lastname: Pezzilli
authors.forename: Maria
authors.initials: M
authors.lastname: Gazouli
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Key
authors.forename: Franco
authors.initials: F
authors.lastname: Bambi
authors.forename: Beatrice
authors.initials: B
authors.lastname: Mohelnikova-Duchonova
authors.forename: Anette
authors.initials: A
authors.lastname: Heller
authors.forename: Stefano
authors.initials: S
authors.lastname: Landi
authors.forename: Ludmila
authors.initials: L
authors.lastname: Vodickova
authors.forename: George
authors.initials: G
authors.lastname: Theodoropoulos
authors.forename: Peter
authors.initials: P
authors.lastname: Bugert
authors.forename: Pavel
authors.initials: P
authors.lastname: Vodicka
authors.forename: Jörg D
authors.initials: JD
authors.lastname: Hoheisel
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Delle Fave
authors.forename: John P
authors.initials: JP
authors.lastname: Neoptolemos
authors.forename: Pavel
authors.initials: P
authors.lastname: Soucek
authors.forename: Markus W
authors.initials: MW
authors.lastname: Büchler
authors.forename: Nathalia
authors.initials: N
authors.lastname: Giese
authors.forename: Federico
authors.initials: F
authors.lastname: Canzian
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000401:mortality; D000328:Adult; D000368:Aged; D001208:Asia / Q000453:epidemiology; D014408:Biomarkers, Tumor / Q000235:genetics*; D021441:Carcinoma, Pancreatic Ductal / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D016022:Case-Control Studies; D005060:Europe / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor