title: A new daidzein derivative from endophytic Streptomyces sp. YIM 65408.
abstract: A new daidzein derivative, 1″-O-methyl-8-hydroxymethyl-daidzein (1) was isolated from Streptomyces sp. YIM 65408 in soybean powder containing medium. The structure was elucidated on the basis of extensive 1D and 2D NMR as well as HR-ESI-MS spectroscopic analyses. The radical-scavenging activity and cytotoxicity of compound 1 were also investigated, and 1 was found to be more active than daidzein in the 2,2-diphenyl-1-picrylhydrazyl method with IC50 at 0.60 mmol/L, but no cytotoxicity of 1 against HL-60, SMMC-7721, A-549, MCF-7 and SW480 cell lines was shown. The possible biosynthesis pathway from daidzein (2) to compound 1 was proposed.
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University , Kunming , 650091 , P.R. China.
authors.forename: Yabin
authors.initials: Y
authors.lastname: Yang
authors.forename: Xueqiong
authors.initials: X
authors.lastname: Yang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Zhou
authors.forename: Jucheng
authors.initials: J
authors.lastname: Zhang
authors.forename: Lihua
authors.initials: L
authors.lastname: Xu
authors.forename: Zhongtao
authors.initials: Z
authors.lastname: Ding
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013025:Glycine max / Q000382:microbiology; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D007529:Isoflavones; C004742:daidzein