title: Triterpenoid saponins from Clematis tangutica and their cardioprotective activities.
abstract: Phytochemical investigation of the whole plants of Clematis tangutica led to the isolation of three new triterpenoid saponins (1-3), together with four known saponins (4-7). Their structures were determined by extensive spectral analysis and chemical evidences. Compounds 1-7 were evaluated for their cardioprotective activities in cardiomyocytes anoxia/reoxygenation (A/R) model. The results showed that those saponins exhibited cardioprotective effects by decreasing the levels of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH).
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Wang
authors.forename: Haifeng
authors.initials: H
authors.lastname: Tang
authors.forename: Minchang
authors.initials: M
authors.lastname: Wang
authors.forename: Lanju
authors.initials: L
authors.lastname: Ji
authors.forename: Aidong
authors.initials: A
authors.lastname: Wen
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D039324:Clematis / Q000737:chemistry*; D000860:Hypoxia; D015394:Molecular Structure; D032383:Myocytes, Cardiac / Q000187:drug effects; D010101:Oxygen Consumption; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D012503:Saponins; D014315:Triterpenes