title: [Normal and abnormal skin color].
abstract: The varieties of normal skin color in humans range from people of "no color" (pale white) to "people of color" (light brown, dark brown, and black). Skin color is a blend resulting from the skin chromophores red (oxyhaemoglobin), blue (deoxygenated haemoglobin), yellow-orange (carotene, an exogenous pigment), and brown (melanin). Melanin, however, is the major component of skin color ; it is the presence or absence of melanin in the melanosomes in melanocytes and melanin in keratinocytes that is responsible for epidermal pigmentation, and the presence of melanin in macrophages or melanocytes in the dermis that is responsible for dermal pigmentation. Two groups of pigmentary disorders are commonly distinguished: the disorders of the quantitative and qualitative distribution of normal pigment and the abnormal presence of exogenous or endogenous pigments in the skin. The first group includes hyperpigmentations, which clinically manifest by darkening of the skin color, and leukodermia, which is characterized by lightening of the skin. Hypermelanosis corresponds to an overload of melanin or an abnormal distribution of melanin in the skin. Depending on the color, melanodermia (brown/black) and ceruloderma (blue/grey) are distinguished. Melanodermia correspond to epidermal hypermelanocytosis (an increased number of melanocytes) or epidermal hypermelanosis (an increase in the quantity of melanin in the epidermis with no modification of the number of melanocytes). Ceruloderma correspond to dermal hypermelanocytosis (abnormal presence in the dermis of cells synthesizing melanins) ; leakage in the dermis of epidermal melanin also exists, a form of dermal hypermelanosis called pigmentary incontinence. Finally, dyschromia can be related to the abnormal presence in the skin of a pigment of exogenous or endogenous origin.
authors.affiliation: Service de Dermatologie, Hôpital Archet- 2, BP 3079, 06202 Nice cedex 3, France. jean-paul.ortonne@unice.fr
authors.forename: J-P
authors.initials: JP
authors.lastname: Ortonne
mesh_terms: D020405:Dermis / Q000503:physiopathology; D003937:Diagnosis, Differential; D004817:Epidermis / Q000503:physiopathology; D005153:Facial Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D017495:Hyperpigmentation / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D015603:Keratinocytes / Q000502:physiology; D017492:Keratosis, Seborrheic / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D007911:Lentigo / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000502:physiology; D020460:Melanosomes / Q000502:physiology; D009507:Nevus of Ota / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D010787:Photosensitivity Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D010859:Pigmentation Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D012867:Skin / Q000503:physiopathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology
chemical_list: D008543:Melanins