title: Torching the Haystack: modelling fast-fail strategies in drug development.
abstract: By quickly clearing the development pipeline of failing or marginal products, fast-fail strategies release resources to focus on more promising molecules. The Quick-Kill model of drug development demonstrates that fast-fail strategies will: (1) reduce the expected time to market; (2) reduce expected R&D costs; and (3) increase R&D productivity. This paper outlines the model and demonstrates the impact of fast-fail strategies. The model is illustrated with costs and risks data from pharmaceutical and biopharmaceutical companies.
authors.affiliation: Institute of Cellular Medicine, University of Newcastle upon Tyne, United Kingdom. dennis.lendrem@newcastle.ac.uk
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Lendrem
authors.forename: B Clare
authors.initials: BC
authors.lastname: Lendrem
mesh_terms: D035843:Biomedical Research / Q000191:economics*; D003365:Costs and Cost Analysis; D055808:Drug Discovery / Q000191:economics*; D004345:Drug Industry / Q000191:economics*; D017598:Efficiency, Organizational; D008962:Models, Theoretical