title: [Losmapimod: a novel drug against cardiovascular diseases?].
abstract: Losmapimod is a promising new agent against cardiovascular diseases. This drug works by inhibiting p38 MAP kinases, which play an important role in the development of atherosclerosis and heart failure caused by ischemic conditions. Preclinical data from in vitro and in vivo studies suggest a protective role of pharmacological p38 inhibition with regard to the development of cardiovascular diseases. This article evaluates the therapeutic potential of this new pharmacological approach and discusses the current clinical data on Losmapimod.
authors.affiliation: Abteilung Pharmakologie, Universitätsmedizin Göttingen, Göttingen.
authors.forename: M
authors.initials: M
authors.lastname: Dewenter
authors.forename: C
authors.initials: C
authors.lastname: Vettel
authors.forename: A
authors.initials: A
authors.lastname: El-Armouche
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy*; D003521:Cyclopropanes / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D011725:Pyridines / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: C543534:6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-N-(2,2-dimethylprpyl)-3-pyridinecarboxamide; D003521:Cyclopropanes; D047428:Protein Kinase Inhibitors; D011725:Pyridines