title: Clinical application of exhaled nitric oxide measurement in pediatric lung diseases.
abstract: Fractional exhaled nitric oxide (FeNO) is a non invasive method for assessing the inflammatory status of children with airway disease. Different ways to measure FeNO levels are currently available. The possibility of measuring FeNO levels in an office setting even in young children, and the commercial availability of portable devices, support the routine use of FeNO determination in the daily pediatric practice. Although many confounding factors may affect its measurement, FeNO is now widely used in the management of children with asthma, and seems to provide significantly higher diagnostic accuracy than lung function or bronchial challenge tests. The role of FeNO in airway infection (e.g. viral bronchiolitis and common acquired pneumonia), in bronchiectasis, or in cases with diffuse lung disease is less clear. This review focuses on the most recent advances and the current clinical applications of FeNO measurement in pediatric lung disease.
authors.affiliation: Department of Pediatrics, Federico II University, Naples, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Manna
authors.forename: Carlo
authors.initials: C
authors.lastname: Caffarelli
authors.forename: Margherita
authors.initials: M
authors.lastname: Varini
authors.forename: Carlotta
authors.initials: C
authors.lastname: Povesi Dascola
authors.forename: Silvia
authors.initials: S
authors.lastname: Montella
authors.forename: Marco
authors.initials: M
authors.lastname: Maglione
authors.forename: Francesco
authors.initials: F
authors.lastname: Sperlì
authors.forename: Francesca
authors.initials: F
authors.lastname: Santamaria
mesh_terms: D001249:Asthma / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D005541:Forced Expiratory Volume; D006801:Humans; D008171:Lung Diseases / Q000503:physiopathology; D009569:Nitric Oxide / Q000032:analysis*; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide