title: Early days in drug discovery by crystallography - personal recollections.
abstract: The influences of Lawrence Bragg and Max Perutz are evident in the contemporary emphasis on 'structural enablement' in drug discovery. On this occasion of the centenary of Bragg's equation, his role in supporting the earliest structural studies of biological materials at the Cavendish Laboratory is remembered. The 1962 Nobel Prizes for the structures of DNA and proteins marked the golden anniversary of the von Laue and Bragg discoveries.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. pcolman@wehi.edu.au
authors.forename: Peter M
authors.initials: PM
authors.lastname: Colman
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D003461:Crystallography / Q000266:history* / Q000379:methods; D004247:DNA / Q000737:chemistry; D055808:Drug Discovery / Q000266:history* / Q000379:methods; D049673:History, 20th Century; D006801:Humans; D009980:Influenza A virus / Q000201:enzymology; D007251:Influenza, Human / Q000188:drug therapy / Q000821:virology; D008958:Models, Molecular; D009439:Neuraminidase / Q000737:chemistry / Q000378:metabolism; D009613:Nobel Prize; D011506:Proteins / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D011506:Proteins; D004247:DNA; D009439:Neuraminidase