title: [Relationship between pesticide exposure and adverse pregnancy outcomes among famers: a meta-analysis].
abstract: OBJECTIVE
  To analyze the relationship between pesticide exposure and adverse pregnancy outcomes in famers.
  
  
  METHODS
  A search was conducted to collect the articles about the relationship between pesticide exposure and adverse pregnancy outcomes published worldwide from 1990 to February 2012. Meta-analysis was performed on the collected articles using RevMan 4.2 software.
  
  
  RESULTS
  Twelve articles were collected. Compared with the controls, the pesticide-exposed famers showed a combined odds ratio (OR) for spontaneous abortion of 1.52 (95%CI: 1.04 ∼ 2.21; P = 0.03), a combined OR for premature birth of 1.33 (95%CI: 1.09 ∼ 1.61; P = 0.005), a combined OR for dead fetus of 1.22 (95%CI: 1.16 ∼ 1.29; P < 0.01), a combined OR for stillbirth of 1.90 (95%CI: 0.58 ∼ 6.28; P = 0.29), a combined OR for birth defect of 2.02 (95%CI: 0.84 - 4.69; P = 0.12), a combined OR for low birth weight of 1.62 (95%CI: 0.60 ∼ 4.39; P = 0.34), a combined OR for neonatal death of 2.18 (95%CI: 0.54 ∼ 8.88; P = 0.28), and a combined OR for delayed conception of 1.43 (95%CI: 0.93 ∼ 2.18; P = 0.1). Pesticide exposure increased the risks for spontaneous abortion, premature birth, and dead fetus, but was not significantly associated with stillbirth, birth defect, low birth weight, neonatal death, and delayed conception.
  
  
  CONCLUSIONS
  Pesticide exposure can cause adverse pregnancy outcomes in farmers, increasing the risks of spontaneous abortion, premature birth, and dead fetus.
authors.affiliation: The department of Public Health, Weifang Medical University, Weifang Shandong Province 261053, China.
authors.forename: Shao-mei
authors.initials: SM
authors.lastname: Yan
authors.forename: Qing-feng
authors.initials: QF
authors.lastname: Zhai
authors.forename: Jie
authors.initials: J
authors.lastname: Xing
authors.forename: Wang-wei
authors.initials: WW
authors.lastname: Li
authors.forename: Xiang-chun
authors.initials: XC
authors.lastname: Gao
authors.forename: Yu-gang
authors.initials: YG
authors.lastname: Qiu
mesh_terms: D000383:Agriculture; D005260:Female; D006801:Humans; D018811:Maternal Exposure; D010575:Pesticides / Q000009:adverse effects*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012424:Rural Population
chemical_list: D010575:Pesticides