title: Catalytic Nazarov reaction of aryl vinyl ketones via binary acid strategy.
abstract: We describe herein a viable binary acid strategy for the catalytic Nazarov reaction of aryl vinyl ketones. Simply combining a Lewis acid and a Brønsted acid led to a dramatic enhancement of the catalytic activity in the Nazarov reaction of aryl vinyl β-ketoesters. The obtained optimal binary acid catalyst In(OTf)(3)/diphenyl phosphoric acid (DPP) can be applied to a range of aryl vinyl ketones with good activity. A trend of reactivity has also been summarized on the basis of mapping of the substituents.
authors.affiliation: Department of Chemistry and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, 300071, China.
authors.forename: Zhi-Guo
authors.initials: ZG
authors.lastname: Xi
authors.forename: Lihui
authors.initials: L
authors.lastname: Zhu
authors.forename: Sanzhong
authors.initials: S
authors.lastname: Luo
authors.forename: Jin-Pei
authors.initials: JP
authors.lastname: Cheng
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007659:Ketones; D058116:Lewis Acids; D009943:Organophosphorus Compounds; D014753:Vinyl Compounds