title: Comprehensive study on associations between nine SNPs and glioma risk.
abstract: OBJECTIVE
  Glioma cancer is the most common type of adult brain tumor. Recent genome-wide association studies (GWAS) have identified various new susceptibility regions and here we conducted an extensive analysis of associations between 12 single nucleotide polymorphisms (SNPs) and glioma risk.
  
  
  METHODS
  A total of 197 glioma cases and 197 health controls were selected, and 9 SNPs in 8 genes were analyzed using the Sequenom MassARRAY platform and Sequenom Assay Design 3.1 software.
  
  
  RESULTS
  We found the MAF among selected controls were consistent with the MAF from the NCBI SNP database. Among 9 SNPs in 8 genes, we identified four significant SNP genotypes associated with the risk of glioma, C/C genotype at rs730437 and T/T genotype at rs1468727 in ERGF were protective against glioma, whereas the T/T genotype at rs1799782 in XRCC1 and C/C genotype at rs861539 in XRCC3 conferred elevated risk.
  
  
  CONCLUSIONS
  Our comprehensive analysis of nine SNPs in eight genes suggests that the rs730437 and rs1468727 in ERGF, rs1799782 in XRCC1 gene, and rs861539 in XRCC3 gene are associated with glioma risk. These findings indicate that genetic variants of various genes play a complex role in the development of glioma.
authors.affiliation: Department of Neurosurgery, Affiliated Nanfang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Liu
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Peng
authors.forename: Chang-Wu
authors.initials: CW
authors.lastname: Dou
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Su
authors.forename: Nai-Kang
authors.initials: NK
authors.lastname: Gao
authors.forename: Fu-Ming
authors.initials: FM
authors.lastname: Tian
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005910:Glioma / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D009363:Neoplasm Proteins