title: Can multiple lifestyle behaviours be improved in people with familial hypercholesterolemia? Results of a parallel randomised controlled trial.
abstract: OBJECTIVE
  To evaluate the efficacy of an individualised tailored lifestyle intervention on physical activity, dietary intake, smoking and compliance to statin therapy in people with Familial Hypercholesterolemia (FH).
  
  
  METHODS
  Adults with FH (n = 340) were randomly assigned to a usual care control group or an intervention group. The intervention consisted of web-based tailored lifestyle advice and face-to-face counselling. Physical activity, fat, fruit and vegetable intake, smoking and compliance to statin therapy were self-reported at baseline and after 12 months. Regression analyses were conducted to examine between-group differences. Intervention reach, dose and fidelity were assessed.
  
  
  RESULTS
  In both groups, non-significant improvements in all lifestyle behaviours were found. Post-hoc analyses showed a significant decrease in saturated fat intake among women in the intervention group (β = -1.03; CI -1.98/-0.03). In the intervention group, 95% received a log on account, of which 49% logged on and completed one module. Nearly all participants received face-to-face counselling and on average, 4.2 telephone booster calls. Intervention fidelity was low.
  
  
  CONCLUSIONS
  Individually tailored feedback is not superior to no intervention regarding changes in multiple lifestyle behaviours in people with FH. A higher received dose of computer-tailored interventions should be achieved by uplifting the website and reducing the burden of screening questionnaires. Counsellor training should be more extensive.
  
  
  BACKGROUND
  Dutch Trial Register NTR1899.
authors.affiliation: Department of Public and Occupational Health, EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands.
authors.forename: Karen
authors.initials: K
authors.lastname: Broekhuizen
authors.forename: Mireille N M
authors.initials: MN
authors.lastname: van Poppel
authors.forename: Lando L
authors.initials: LL
authors.lastname: Koppes
authors.forename: Iris
authors.initials: I
authors.lastname: Kindt
authors.forename: Johannes
authors.initials: J
authors.lastname: Brug
authors.forename: Willem
authors.initials: W
authors.lastname: van Mechelen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003376:Counseling; D004032:Diet / Q000523:psychology*; D015444:Exercise / Q000523:psychology*; D005260:Female; D005638:Fruit; D015438:Health Behavior; D006293:Health Promotion / Q000379:methods; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy / Q000523:psychology*; D008019:Life Style; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014675:Vegetables
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors