title: Curcumin reverses glomerular hemodynamic alterations and oxidant stress in 5/6 nephrectomized rats.
abstract: The administration of curcumin before and throughout the study attenuates oxidant stress and glomerular hemodynamic alterations induced by 5/6 nephrectomy (5/6NX). The purpose of this work was to study if curcumin is able to reverse established glomerular hemodynamic alterations (e.g. hyperfiltration and glomerular hypertension) and oxidant stress in rats with 5/6NX. Curcumin (120 mg/kg) was given to rats with established renal injury (30 days after surgery) and continued for 30 days (days 31-60 of the study). All rats were studied on day 60 after surgery. Curcumin was able (a) to reverse 5/6NX-induced glomerular hypertension and hyperfiltration, (b) to induce cell proliferation and nuclear translocation of Nrf2 and (c) to reverse 5/6NX-induced oxidant stress and decrease in antioxidant enzymes. These beneficial effects of curcumin were associated with the ability of this antioxidant to reverse renal structural alterations, proteinuria, hypertension, interstitial fibrosis, fibrotic glomeruli, tubular atrophy and mesangial expansion. It has been shown for the first time that curcumin is able to reverse established oxidants stress glomerular hypertension and hyperfiltration in rats with 5/6NX. These novel findings may play a key role in the attenuation of proteinuria and progression of renal damage in rats with 5/6NX. These data suggest that curcumin may be useful to reverse established hemodynamic alterations and renal injury in patients with chronic renal failure.
authors.affiliation: Renal Pathophysiology Laboratory, Department of Nephrology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. ediliatapia@hotmail.com
authors.forename: Edilia
authors.initials: E
authors.lastname: Tapia
authors.forename: Zyanya Lucía
authors.initials: ZL
authors.lastname: Zatarain-Barrón
authors.forename: Rogelio
authors.initials: R
authors.lastname: Hernández-Pando
authors.forename: Guillermo
authors.initials: G
authors.lastname: Zarco-Márquez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Molina-Jijón
authors.forename: Magdalena
authors.initials: M
authors.lastname: Cristóbal-García
authors.forename: José
authors.initials: J
authors.lastname: Santamaría
authors.forename: José
authors.initials: J
authors.lastname: Pedraza-Chaverri
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002467:Cell Nucleus / Q000378:metabolism; D003474:Curcumin / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006439:Hemodynamics / Q000187:drug effects; D007150:Immunohistochemistry; D007674:Kidney Diseases / Q000188:drug therapy*; D007678:Kidney Glomerulus / Q000187:drug effects*; D008297:Male; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D009392:Nephrectomy; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D011507:Proteinuria / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D051267:NF-E2-Related Factor 2; C495637:Nfe2l2 protein, rat; D003474:Curcumin