title: Assessment of the cytotoxic and anti-viral potential of aqueous extracts from different parts of Acacia nilotica (Linn) Delile against Peste des petits ruminants virus.
abstract: Peste des petits ruminants virus (PPRV); a negative sense single stranded RNA enveloped virus that causes Peste des petits ruminants (PPR), is dramatically affecting the health status of ruminants all around the world resulting in extensive economical losses in livestock sector. Acacia nilotica (Linn) Delile; a tannin-rich medicinal plant distributed throughout subcontinent, is traditionally used as food for ruminants and possesses anti-viral potential against different RNA viruses. In the current study, aqueous extracts from the bark, leaves and pods of A. nilotica (Linn) Delile indica were evaluated for their cytotoxicity and anti-viral activities against PPRV by adopting MTT colorimetric assay and anti-viral assay using Vero cell line. Aqueous extract from the leaves presented significantly better (P<0.05) anti-PPRV activities in comparison to pods extract. On the contrary, bark extract did not show any anti-viral activity. The data presented in the study could pave a way toward the discovery of novel anti-viral chemicals in the plants against PPRV and other viral diseases.
authors.affiliation: Department of Pharmacology & Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
authors.forename: Rizwana
authors.initials: R
authors.lastname: Raheel
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.forename: Sohail
authors.initials: S
authors.lastname: Ejaz
authors.forename: Aqeel
authors.initials: A
authors.lastname: Javeed
authors.forename: Imran
authors.initials: I
authors.lastname: Altaf
mesh_terms: D000045:Acacia; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D015169:Colony Count, Microbial; D018107:Peste-des-petits-ruminants virus / Q000187:drug effects* / Q000254:growth & development; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D012639:Seeds; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts