title: Warthin's tumor associated with IgG4-related disease.
abstract: Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. Several inflammatory conditions associated with IgG4-RD have been reported. Warthin's tumor is a benign parotid gland tumor consisting of oncocytic epithelial cells and lymphoid stroma containing lymphoid follicles with reactive germinal centers. This is the first report describing a case of Warthin's tumor with possible involvement of IgG4-RD. The patient was a 71-year-old man presenting with swollen right parotid and bilateral submandibular glands. He had a history of a Warthin's tumor of the left parotid gland, autoimmune pancreatitis, and an inflammatory abdominal aortic aneurysm. Laboratory tests revealed a high serum IgG4 level. Histological examination of the resected parotid gland showed a Warthin's tumor and a nodule showing severe lymphocytic infiltration containing many IgG4-positive plasma cells. This case shows the possible involvement of Warthin's tumor with IgG4-RD.
authors.affiliation: Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Aga
authors.forename: Satoru
authors.initials: S
authors.lastname: Kondo
authors.forename: Kazunori
authors.initials: K
authors.lastname: Yamada
authors.forename: Seiko
authors.initials: S
authors.lastname: Sawada-Kitamura
authors.forename: Sayaka
authors.initials: S
authors.lastname: Yagi-Nakanishi
authors.forename: Kazuhira
authors.initials: K
authors.lastname: Endo
authors.forename: Naohiro
authors.initials: N
authors.lastname: Wakisaka
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Murono
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kawano
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Yoshizaki
mesh_terms: D000235:Adenolymphoma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000276:immunology; D007074:Immunoglobulin G; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000150:complications* / Q000276:immunology / Q000473:pathology; D010195:Pancreatitis / Q000150:complications / Q000276:immunology; D010307:Parotid Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology
chemical_list: D007074:Immunoglobulin G