title: Cognitive inhibition and quality of life in schizophrenia: a pilot study.
abstract: OBJECTIVE
  To compare cognitive inhibition and quality of life in patients with schizophrenia and healthy controls.
  
  
  METHODS
  Ten patients with schizophrenia were compared to 10 healthy controls, matched for age, sex, and educational level. Cognitive inhibition was examined by: 1) access to relevant information (Reading with distraction task), 2) suppression of no longer relevant information (Trail Making Test), and 3) restraint of cognitive resources to relevant information (Stroop Test, Hayling Sentence Completion Test, Go/No-Go Test). Montgomery Asberg Depression Rating Scale, Positive and Negative Syndrome Scale, and Schizophrenia-Quality of Life scale (S-QoL) were also used.
  
  
  RESULTS
  Patients with schizophrenia showed a significant impairment in the suppression function of cognitive inhibition only, in comparison to the control group. Their access and restraint functions of cognitive inhibition were preserved. No relationship between quality of life and cognitive inhibition was found in patients with schizophrenia.
  
  
  CONCLUSIONS
  During the stabilization phase of schizophrenia, the ability to inhibit neutral information access to working memory, and to restrain and suppress irrelevant information may not impair the patient's capacity to respond adequately to stressful situations, and thus would do not impact their quality of life.
authors.affiliation: Secteur 5, CESAME, CHS, Ste Gemmes sur Loire, 27 route de Bouchemaine, 49 050 Les Ponts-de-cé, France.
authors.forename: J
authors.initials: J
authors.lastname: Gigaux
authors.forename: D
authors.initials: D
authors.lastname: Le Gall
authors.forename: F
authors.initials: F
authors.lastname: Jollant
authors.forename: J P
authors.initials: JP
authors.lastname: Lhuillier
authors.forename: S
authors.initials: S
authors.lastname: Richard-Devantoy
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010865:Pilot Projects; D011788:Quality of Life / Q000523:psychology*; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology