title: Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform.
abstract: The focus of nanoparticle design over the years has evolved toward more complex nanoscopic core-shell architecture using a single delivery system to combine multiple functionalities within nanoparticles. Core-shell-type lipid-polymer hybrid nanoparticles (CSLPHNs), which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes, have emerged as a robust and promising delivery platform. In CSLPHNs, a biodegradable polymeric core is surrounded by a shell composed of layer(s) of phospholipids. The hybrid architecture can provide advantages such as controllable particle size, surface functionality, high drug loading, entrapment of multiple therapeutic agents, tunable drug release profile, and good serum stability. This review focuses on current research trends on CSLPHNs including classification, advantages, methods of preparation, physicochemical characteristics, surface modifications, and immunocompatibility. Additionally, the review deals with applications for cancer chemotherapy, vaccines, and gene therapeutics.
  
  
  BACKGROUND
  This comprehensive review covers the current applications of core-shell-type lipid-polymer hybrid nanoparticles, which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes to enable an efficient drug delivery system.
authors.affiliation: Plough Center for Sterile Drug Delivery Systems, Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
authors.forename: Bivash
authors.initials: B
authors.lastname: Mandal
authors.forename: Himanshu
authors.initials: H
authors.lastname: Bhattacharjee
authors.forename: Nivesh
authors.initials: N
authors.lastname: Mittal
authors.forename: Hongkee
authors.initials: H
authors.lastname: Sah
authors.forename: Pavan
authors.initials: P
authors.lastname: Balabathula
authors.forename: Laura A
authors.initials: LA
authors.lastname: Thoma
authors.forename: George C
authors.initials: GC
authors.lastname: Wood
mesh_terms: D016503:Drug Delivery Systems; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles; D011108:Polymers / Q000737:chemistry*
chemical_list: D008055:Lipids; D011108:Polymers