title: Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
abstract: OBJECTIVE
  Alcohol intake may adversely affect the concentrations of endogenous sex hormones, and thus increase the risk of endometrial cancer. However, epidemiologic studies have provided conflicting results. Therefore, we investigated the association between alcohol intake and endometrial cancer risk a large, multicenter, prospective study.
  
  
  METHODS
  From 1992 through 2010, 301,051 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were followed for incident endometrial cancer (n = 1382). Baseline alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models.
  
  
  RESULTS
  The multivariable HRs (and 95% CIs) compared with light drinkers (0.1-6 g/d) were 1.03 (0.88-1.20) for 0 g of alcohol per day at baseline, 1.01 (0.86-1.17) for 6.1-12 g/d, 1.03 (0.87-1.22) for 12.1-24 g/d, 1.07 (0.87-1.38) for 24.1-36 g/d, and 0.85 (0.61-1.18) for more than 36 g/d (p(trend) = 0.77). No association was observed among former drinkers (OR, 1.28; 95% CI, 0.98-1.68 compared with light drinkers). Null associations were also found between alcohol consumption at age 20 years, lifetime pattern of alcohol drinking, and baseline alcohol intake from specific alcoholic beverages and endometrial cancer risk.
  
  
  CONCLUSIONS
  Our findings suggest no association between alcohol intake and endometrial cancer risk.
authors.affiliation: International Agency for Research on Cancer (IARC-WHO), Lyon, France. nep.iarc.fr
authors.forename: Veronika
authors.initials: V
authors.lastname: Fedirko
authors.forename: Mazda
authors.initials: M
authors.lastname: Jenab
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Carine
authors.initials: C
authors.lastname: Biessy
authors.forename: Naomi E
authors.initials: NE
authors.lastname: Allen
authors.forename: Laure
authors.initials: L
authors.lastname: Dossus
authors.forename: N Charlotte
authors.initials: NC
authors.lastname: Onland-Moret
authors.forename: Madlen
authors.initials: M
authors.lastname: Schütze
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Louise
authors.initials: L
authors.lastname: Hansen
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chabbert-Buffet
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Annekatrin
authors.initials: A
authors.lastname: Lukanova
authors.forename: Manuela M
authors.initials: MM
authors.lastname: Bergmann
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Erifili
authors.initials: E
authors.lastname: Oustoglou
authors.forename: Antonia
authors.initials: A
authors.lastname: Barbitsioti
authors.forename: Calogero
authors.initials: C
authors.lastname: Saieva
authors.forename: Giovanna
authors.initials: G
authors.lastname: Tagliabue
authors.forename: Rocco
authors.initials: R
authors.lastname: Galasso
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacerdote
authors.forename: Petra H
authors.initials: PH
authors.lastname: Peeters
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Elisabete
authors.initials: E
authors.lastname: Weiderpass
authors.forename: Inger Torhild
authors.initials: IT
authors.lastname: Gram
authors.forename: Soledad
authors.initials: S
authors.lastname: Sanchez
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Duell
authors.forename: Esther
authors.initials: E
authors.lastname: Molina-Montes
authors.forename: Larraitz
authors.initials: L
authors.lastname: Arriola
authors.forename: Maria-Dolores
authors.initials: MD
authors.lastname: Chirlaque
authors.forename: Eva
authors.initials: E
authors.lastname: Ardanaz
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Eva
authors.initials: E
authors.lastname: Lundin
authors.forename: Annika
authors.initials: A
authors.lastname: Idahl
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Dora
authors.initials: D
authors.lastname: Romaguera-Bosch
authors.forename: Petra A
authors.initials: PA
authors.lastname: Wark
authors.forename: Teresa
authors.initials: T
authors.lastname: Norat
authors.forename: Isabelle
authors.initials: I
authors.lastname: Romieu
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000453:epidemiology; D000434:Alcoholic Beverages / Q000009:adverse effects; D016001:Confidence Intervals; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000209:etiology; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008019:Life Style; D008875:Middle Aged; D016017:Odds Ratio; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires