title: Aging: one thing leads to another.
abstract: Mitochondria deteriorate during the aging process, but the underlying mechanisms for the decline of this critical organelle are unknown. A new study indicates that in yeast an age-dependent reduction in vacuolar acidification leads to mitochondrial dysfunction through a surprising mechanism: loss of vacuolar neutral amino acid transport.
authors.affiliation: Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. marion.schmidt@einstein.yu.edu
authors.forename: Marion
authors.initials: M
authors.lastname: Schmidt
authors.forename: Brian K
authors.initials: BK
authors.lastname: Kennedy
mesh_terms: D000375:Aging / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*