title: Cortisol and ghrelin concentrations following a cold pressor stress test in overweight individuals with and without night eating.
abstract: OBJECTIVE
  To explore appetite-related hormones following stress in overweight individuals, and their relationship with night eating (NE) status.
  
  
  METHODS
  We measured plasma cortisol and ghrelin concentrations, and recorded ratings of stress and hunger in response to a physiological laboratory stressor (cold pressor test, CPT), in overweight women with (n=11; NE) and without (n=17; non-NE) NE.
  
  
  RESULTS
  Following the CPT, cortisol (P<0.001) and ghrelin (P<0.05) levels increased, as did stress and hunger ratings (all P<0.001), across all subjects (NE and non-NE). NE exhibited higher baseline cortisol (P<0.05) levels than non-NE. NE also had greater cortisol area under the curve (AUC) than non-NE (P=0.019), but not when controlling for baseline cortisol levels. Ghrelin baseline and AUC did not differ between groups. NE showed higher AUC stress (P<0.05), even when controlling for baseline stress.
  
  
  CONCLUSIONS
  Overweight individuals showed increased cortisol, ghrelin, stress and hunger following a laboratory stressor, and there was some evidence for greater increases in cortisol and subjective stress among NE. The greater AUC cortisol level in NE was due to higher baseline levels, but the group difference in stress was in direct response to the stressor. Our results support a role for cortisol and stress in NE.
authors.affiliation: New York Obesity Nutrition Research Center, Department of Medicine, St Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA. ag58@columbia.edu
authors.forename: A
authors.initials: A
authors.lastname: Geliebter
authors.forename: S
authors.initials: S
authors.lastname: Carnell
authors.forename: M E
authors.initials: ME
authors.lastname: Gluck
mesh_terms: D000328:Adult; D019540:Area Under Curve; D015992:Body Mass Index; D003080:Cold Temperature; D004435:Eating / Q000523:psychology; D005247:Feeding Behavior; D005260:Female; D054439:Ghrelin / Q000378:metabolism*; D006801:Humans; D006815:Hunger; D006854:Hydrocortisone / Q000378:metabolism*; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D012893:Sleep Wake Disorders / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D013312:Stress, Physiological; D013315:Stress, Psychological; D013997:Time Factors; D014481:United States / Q000453:epidemiology
chemical_list: D054439:Ghrelin; D006854:Hydrocortisone