title: Simultaneous presentation in the neck and abdomen of malignant peripheral nerve sheath tumors involving two different nerve tracts.
abstract: Neurofibromatosis-1 (NF-1) is a relatively common autosomal dominant disease and it is caused by mutation of the NF-1 tumor suppressor gene; hence, the individuals affected have increased risk for developing familial cancer. Abdominal cavity neurofibromas are common but the simultaneous occurrence of a malignant peripheral nerve sheath tumor (MPNST) in the chest and in the abdomen is rare. Here, we present a patient with MPNST (spindle cell sarcoma) affecting simultaneously the vagus nerve in the head and neck region, mediastinum, pleura as well as celiac plexus branches near the stomach.
authors.affiliation: Department of Internal Medicine, Mount Sinai School of Medicine/Queens Hospital Center, 62-86 164th Street, Jamaica, NY 11432, USA. siderasp@hotmail.com
authors.forename: Panagiotis A
authors.initials: PA
authors.lastname: Sideras
authors.forename: Felipe
authors.initials: F
authors.lastname: Castorena
authors.forename: Jaswinder
authors.initials: J
authors.lastname: Singh
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002100:Cachexia; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006738:Hospices; D006801:Humans; D007813:Laparotomy; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D009434:Neural Pathways / Q000473:pathology*; D009456:Neurofibromatosis 1 / Q000473:pathology; D019635:Neurosurgical Procedures / Q000379:methods; D010524:Peripheral Nervous System Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D014057:Tomography, X-Ray Computed