title: [Changes of adhesion molecules and adenosine in divers post 480 heliox saturation diving].
abstract: OBJECTIVE
  To investigate the changes of adhesion molecules, cyclic adenosine monophosphate(cAMP) and cyclic guanosine monophosphate (cGMP) in divers post 480 heliox saturation diving.
  
  
  METHODS
  Four divers were compressed within 96 hours to depths of 480 m with heliox-oxygen and held at the designated depth for 49 hours, excursion to 493 m during their saturation stay, then decompressed within 302 hours to the surface. The blood samples were collected before compression and post decompression, the expression level of intercellular adhesion molecule-1(ICAM-1), E-selectin, P-selectin, cAMP, cGMP were detected with ELISA analysis box.
  
  
  RESULTS
  Compared with the levels of CAMs before compression, the levels of ICAM-1, E-selectin, P-selectin and cGMP in the serum were changed post decompression (P > 0.05). The levels of cAMP were significantly elevated post decompression (629.91 +/- 75.01) nmol/L vs (66.72 +/- 83.15) (P < 0.05).
  
  
  CONCLUSIONS
  The decompression schedule in this heliox saturation diving is safe, the decompression sickness pathology in this diving has not been induced. But the stress response of divers are enhanced by this great depth saturation diving.
authors.affiliation: Chinese People's Liberation Army Naval Medical Research Institute, Shanghai 200433, China.
authors.forename: Xiao-Chen
authors.initials: XC
authors.lastname: Bao
authors.forename: Yi-Quna
authors.initials: YQ
authors.lastname: Fang
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Miao
authors.initials: M
authors.lastname: Meng
authors.forename: Wei-Bing
authors.initials: WB
authors.lastname: Xiao
mesh_terms: D000242:Cyclic AMP / Q000097:blood*; D004242:Diving / Q000502:physiology*; D019040:E-Selectin / Q000097:blood*; D006371:Helium; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D010100:Oxygen; D019007:P-Selectin / Q000097:blood*
chemical_list: D019040:E-Selectin; D019007:P-Selectin; D018799:Intercellular Adhesion Molecule-1; D006371:Helium; C038949:heliox; D000242:Cyclic AMP; D010100:Oxygen