title: Children's Oncology Group's 2013 blueprint for research: rare tumors.
abstract: In the US, approximately 2,000 children are diagnosed with rare cancers each year, with 5-year survival ranging from <20% for children with advanced carcinomas to >95% for children with intraocular retinoblastoma or localized germ cell tumors. During the last years, 12 clinical studies have been successfully completed in children with retinoblastoma, liver tumors, germ cell tumors, and infrequent malignancies, including therapeutic, epidemiologic, and biologic studies. Current efforts are centered in the development of large international collaborations to consolidate evidence-based definitions and risk stratifications that will support international Phase 3 clinical trials in germ cell tumors, hepatoblastoma, and other rare cancers.
authors.affiliation: Dana-Farber/Children's Hospital Cancer Center, Harvard Medical School, Boston, MA 02115, USA. carlos_rodriguez-galindo@dfci.harvard.edu
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodriguez-Galindo
authors.forename: Mark
authors.initials: M
authors.lastname: Krailo
authors.forename: Lindsay
authors.initials: L
authors.lastname: Frazier
authors.forename: Murali
authors.initials: M
authors.lastname: Chintagumpala
authors.forename: James
authors.initials: J
authors.lastname: Amatruda
authors.forename: Howard
authors.initials: H
authors.lastname: Katzenstein
authors.forename: Marcio
authors.initials: M
authors.lastname: Malogolowkin
authors.forename: Logan
authors.initials: L
authors.lastname: Spector
authors.forename: Farzana
authors.initials: F
authors.lastname: Pashankar
authors.forename: Rebecka
authors.initials: R
authors.lastname: Meyers
authors.forename: Gail
authors.initials: G
authors.lastname: Tomlinson
mesh_terms: D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000453:epidemiology* / Q000628:therapy*; D035583:Rare Diseases / Q000453:epidemiology* / Q000628:therapy*; D012106:Research