title: Functional connectivity changes in patients with absence epilepsy studied using resting-state functional MRI.
abstract: Functional connectivity is altered in several mental disorders. We used resting-state functional MRI to examine the alterations in functional connectivity that occur in patients with absence epilepsy. We found an altered functional connectivity within and between functional modules in patients with absence epilepsy. Some brain regions had a greater number of altered connections. The functional connectivity within and between modules in absence epilepsy patients showed an increase in the number of positive connections and a decrease in the number of the negative connections. In particular, the superior frontal gyrus demonstrated both an increased number of connections with other nodes of the frontal default mode network and a decreased number of connections with the limbic system. These findings provide a new perspective and shed light on how the balance of connections within and between modules may contribute to the development of absence epilepsy.
authors.affiliation: Beijing Functional Neurosurgery Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China. victorft369@yahoo.com
authors.forename: Tie
authors.initials: T
authors.lastname: Fang
authors.forename: Fang
authors.initials: F
authors.lastname: Fang
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhu
authors.forename: Guojun
authors.initials: G
authors.lastname: Zhang
authors.forename: Zhuxiang
authors.initials: Z
authors.lastname: Liu
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D002648:Child; D004832:Epilepsy, Absence / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology*; D012146:Rest; D055815:Young Adult