title: Rare and recurrent chromosomal abnormalities and their clinical relevance in pediatric acute leukemia of south Indian population.
abstract: OBJECTIVE
  This cytogenetic study detects a wide variety of common, rare and novel chromosomal abnormalities in patients with hematological disorders, providing valuable diagnostic and prognostic information.
  
  
  METHODS
  We addressed the utility of the cytogenetic technique in 50 patients of pediatric acute leukemia prospectively.
  
  
  RESULTS
  Successful cultures were found in 44 patients (88%) and abnormal karyotypes in 22 (44%). The common abnormalities like hyperdiploidy, del(6q), t(1;19)(q23;p13), t(4;11)(q22;q23), t(9;22)(q34;q11), rare t(2;7)(q23;p11) and t(4;12)(q21;p13) and a novel translocation t(7;9)(q22;q21) were observed in acute lymphoblastic leukemia. In acute myeloid leukemia, t(8;21)(q22;q22), del(16)(q22), t(15;17)(q22;q21) and t(9;11)(p22;q23) were commonly seen.
  
  
  CONCLUSIONS
  Chromosomal abnormalities of this small group of patients are compared with the relevant literature with respect to the incidence rate and prognosis.
authors.affiliation: Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India.
authors.forename: Seyed Hashem Mir
authors.initials: SH
authors.lastname: Mazloumi
authors.forename: Prasanna
authors.initials: P
authors.lastname: Kumari
authors.forename: D S
authors.initials: DS
authors.lastname: Madhumathi
authors.forename: L
authors.initials: L
authors.lastname: Appaji