title: A fast protocol for infarct quantification in mice.
abstract: OBJECTIVE
  To demonstrate and validate a late gadolinium enhancement (LGE) imaging protocol, optimized for tissue viability assessment in interventional mouse models of myocardial infarction.
  
  
  METHODS
  The method uses an efficient sampling scheme using multiple slices in a single heartbeat interleaving slice packages between alternate TRs. Sampling multiple slices instead of multiple echoes or multiple k-lines achieves higher SNR efficiency, and images covering the whole heart can be obtained in 3 min. Saturation effects are exploited for an optimum compromise between contrast and speed.
  
  
  RESULTS
  The images obtained show high hyperenhancement with good contrast-to-noise. It is shown that inversion time optimization can be reliably omitted with this scheme, and that measured infarct sizes correlate well with histological measures.
  
  
  CONCLUSIONS
  Our protocol offers a new efficient tool for the measurement of infarct size in mouse models of heart disease.
authors.affiliation: Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Guido
authors.initials: G
authors.lastname: Buonincontri
authors.forename: Carmen
authors.initials: C
authors.lastname: Methner
authors.forename: Thomas
authors.initials: T
authors.lastname: Krieg
authors.forename: T Adrian
authors.initials: TA
authors.lastname: Carpenter
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Sawiak
mesh_terms: D000465:Algorithms; D000818:Animals; D003287:Contrast Media; D005240:Feasibility Studies; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D051379:Mice; D009203:Myocardial Infarction / Q000473:pathology*; D009942:Organometallic Compounds; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol
keywords: TI optimization; ischemia; late gadolinium enhancement (LGE); myocardial infarction