title: 5% lidocaine medicated plaster use in children with neuropathic pain from burn sequelae.
abstract: OBJECTIVE
  Neuropathic pain is a challenge in children with burn sequelae. Although relatively infrequent, the intensity and chronicity of neuropathic pain negatively impact functionality and quality of life. The use of 5% lidocaine medicated plaster has not previously been reported in children. We explored the effectiveness and safety of 5% lidocaine medicated plaster to treat neuropathic pain in children with burn sequelae.
  
  
  METHODS
  Three-month prospective, uncontrolled study.
  
  
  METHODS
  Corporation of Aid to Burned Children (COANIQUEM), a nonprofit pediatric burn rehabilitation center in Chile.
  
  
  METHODS
  Fourteen pediatric patients with burn sequelae neuropathic pain.
  
  
  METHODS
  Demographics, burn and pain evolution (type, intensity [using Wong-Baker FACES], and Douleur Neuropathique 4 [DN4]), and patient functionality. Plasma lidocaine levels were measured at 0, 12, 36, and 60 hours after treatment commencement.
  
  
  RESULTS
  Fourteen patients were evaluable for plasma lidocaine levels. Twelve patients were available for clinical assessment (two patients lost to follow-up) [mean (standard deviation)]: age, 11 years 7 months (2 years 6 months); weight, 45 kg (11.9 kg); burn evolution, 5 years 6 months (4 years); time between burn and pain onset, 3 years 6 months (3 years 2 months); time between pain onset and treatment, 5.1 months (4.8 months); lidocaine, between < and ½ plaster; initial pain intensity (FACES), 6.8 (1.6); final pain intensity, 0 in 11/12 patients; DN4, initial-6, final-2.3. All patients reported improved functionality. Plasma lidocaine levels were ≤27.45 ng/mL (>180 times below critical levels). No adverse reactions occurred.
  
  
  CONCLUSIONS
  These are the first published data suggesting that 5% lidocaine medicated plaster improves patient functionality, and is effective and safe for the treatment of neuropathic pain in pediatric patients with burn sequelae.
authors.affiliation: Pain Unit, Department of Rehabilitation, COANIQUEM (Corporation of Aid to Burned Children), Santiago, Chile. morellana@coaniquem.cl
authors.forename: Matias
authors.initials: M
authors.lastname: Orellana Silva
authors.forename: Veronica
authors.initials: V
authors.lastname: Yañez
authors.forename: Gabriela
authors.initials: G
authors.lastname: Hidalgo
authors.forename: Fernando
authors.initials: F
authors.lastname: Valenzuela
authors.forename: Rolando
authors.initials: R
authors.lastname: Saavedra
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000097:blood; D001458:Bandages; D002056:Burns / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine