title: The effect of emulsifying wax on the physical properties of CTAB-based solid lipid nanoparticles (SLN).
abstract: The objective of this study was to investigate the effect of cetyl alcohol (CA) and Tween® 60 (polysorbate), the primary components of emulsifying wax, on the size, zeta potential and stability of cetyltrimethyl ammonium bromide (CTAB)-based solid lipid nanoparticles (SLN) by D-optimal mixture design. A binary CTAB/polysorbate surfactant blend did not offer an advantage over a simple CTAB-stabilized SLN. This led to the conclusion that emulsifying wax could be readily substituted with CA in simple SLNs based on binary CTAB/CA blends. Polysorbate, however, may be added as a co-emulsifier to adjust the physical properties of the nanoparticles, as dictated by the formulator.
authors.affiliation: College of Pharmacy, Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe , Monroe, LA , USA.
authors.forename: Akhtar
authors.initials: A
authors.lastname: Siddiqui
authors.forename: Alaadin
authors.initials: A
authors.lastname: Alayoubi
authors.forename: Sami
authors.initials: S
authors.lastname: Nazzal
mesh_terms: D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry*; D045703:Emulsifying Agents / Q000737:chemistry*; D005233:Fatty Alcohols / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D014885:Waxes / Q000737:chemistry*
chemical_list: D002593:Cetrimonium Compounds; D045703:Emulsifying Agents; D005233:Fatty Alcohols; D008055:Lipids; D011136:Polysorbates; D013501:Surface-Active Agents; D014885:Waxes; C005031:cetyl alcohol; D000077286:Cetrimonium