title: Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.
abstract: Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.
authors.affiliation: Center for Imaging Science, Institute for Computational Medicine and Department of Applied Mathematics and Statistics, Johns Hopkins University, WSE, Baltimore, Maryland.
authors.forename: Laurent
authors.initials: L
authors.lastname: Younes
authors.forename: J Tilak
authors.initials: JT
authors.lastname: Ratnanather
authors.forename: Timothy
authors.initials: T
authors.lastname: Brown
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Aylward
authors.forename: Peg
authors.initials: P
authors.lastname: Nopoulos
authors.forename: Hans
authors.initials: H
authors.lastname: Johnson
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Magnotta
authors.forename: Jane S
authors.initials: JS
authors.lastname: Paulsen
authors.forename: Russell L
authors.initials: RL
authors.lastname: Margolis
authors.forename: Roger L
authors.initials: RL
authors.lastname: Albin
authors.forename: Michael I
authors.initials: MI
authors.lastname: Miller
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Ross
mesh_terms: D000328:Adult; D001284:Atrophy / Q000473:pathology; D001479:Basal Ganglia / Q000473:pathology*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D062706:Prodromal Symptoms
keywords: diffeomorphic mapping; pallidus atrophy; striatal atrophy; surface registration; surface-based morphometry