title: Enhancing long-term weight loss maintenance: 2 year results from the Keep It Off randomized controlled trial.
abstract: OBJECTIVE
  The Keep It Off trial evaluated the efficacy of a phone-based weight loss maintenance intervention among adults who had recently lost weight in Minnesota (2007-2010).
  
  
  METHODS
  419 adults who had recently lost ≥ 10% of their body weight were randomized to the "Guided" or "Self-Directed" intervention. Guided participants received a 10 session workbook, 10 biweekly, eight monthly and six bimonthly phone coaching calls, bimonthly weight graphs and tailored letters based on self-reported weights. Self-Directed participants received the workbook and two calls. Primary outcomes are weight change and maintenance (regain of <2.5% of baseline body weight).
  
  
  RESULTS
  Mixed model repeated-measures analysis examining weight change revealed a significant time by treatment group interaction (p<0.0085). Guided participants regained significantly less weight than the Self-Directed participants at 12 and 24 months. The odds of 24 month maintenance were 1.37 (95% CI: 0.97-2.03) times greater in the Guided than in the Self-Directed group. When maintenance rates were compared across all follow-ups, there was a consistently higher maintenance rate for Guided participants (HR 1.31, 95% CI: 1.12-1.54).
  
  
  CONCLUSIONS
  A sustained, supportive phone- and mail-based intervention promotes weight loss maintenance relative to a brief intervention for participants who have recently lost weight.
authors.affiliation: HealthPartners Institute for Education and Research, Minneapolis, MN, USA. Nancy.E.Sherwood@HealthPartners.com
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Sherwood
authors.forename: A Lauren
authors.initials: AL
authors.lastname: Crain
authors.forename: Brian C
authors.initials: BC
authors.lastname: Martinson
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Anderson
authors.forename: Marcia G
authors.initials: MG
authors.lastname: Hayes
authors.forename: Julie D
authors.initials: JD
authors.lastname: Anderson
authors.forename: Meghan M
authors.initials: MM
authors.lastname: Senso
authors.forename: Robert W
authors.initials: RW
authors.lastname: Jeffery
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000628:therapy*; D055502:Secondary Prevention; D016896:Treatment Outcome; D015431:Weight Loss; D061217:Weight Reduction Programs