title: [A case of advanced rectal cancer with bladder carcinoma salvaged from myocardial infarction during operation, showing tumor regression by XELOX treatment, good quality of life].
abstract: We report a case of advanced rectal cancer with bladder carcinoma. The patient was a 81-year-old man who complained of abdominal bloating. A colonoscopy showed that he had advanced lower rectal cancer. CT scan revealed many lymph node metastases around the tumor, and also a bladder tumor. He experienced myocardial infarction during the operation but was relieved by PCI. During the operation, sigmoid colostomy was performed. The curative operation was declined and chemotherapy was selected. Capecitabine(2, 000mg/m / 2, biweekly)plus oxaliplatin(130mg/m2, day 1)was selected. At first, he complained of peripheral vein pain. The speed of oxaliplatin infusion was slowed and the pain was relieved. He had Grade 3 platelet decrease, but the number improved after 3 weeks. The tumor marker decreased after 3 courses, 6 courses after CT scan revealed that the tumor and lymph node metastases had evidently decreased. Capecitabine plus oxaliplatin(XELOX)was considered to be a useful chemotherapy against advanced rectal cancer, even for older patients or high risk groups.
authors.affiliation: Dept. of Surgery, Shinsei Hospital, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Okumura
authors.forename: Souichiro
authors.initials: S
authors.lastname: Tani
authors.forename: Yoji
authors.initials: Y
authors.lastname: Shiogai
authors.forename: Masashi
authors.initials: M
authors.lastname: Kodama
authors.forename: Eiji
authors.initials: E
authors.lastname: Mekata
authors.forename: Toru
authors.initials: T
authors.lastname: Tani
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D000069287:Capecitabine; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D007431:Intraoperative Complications / Q000628:therapy*; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology* / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy*; D010071:Oxaloacetates; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D016879:Salvage Therapy; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
chemical_list: D010071:Oxaloacetates; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil