title: The tissue-specific "ferromagnetic attack" on hyperactivation of ATP synthesis by magnesium-25 in mitochondria.
abstract: A (25)Mg(2+)-operated hyper-activation of ATP synthesis has been investigated in mitochondria (Mt) isolated from iron-rich and iron-poor rat tissues: spleen, liver, skeletal muscle, myocardium, kidneys, brain. Both magnetic ((25)Mg) and non-magnetic ((24)Mg) magnesium isotopes were separately administered to estimate the degree of the ATP production related to the magnetic isotope effect (MIE) of (25)Mg(2+)as a function of the amount of Mt-endogenous iron ions. A strong but negative (r = -0.88) correlation between the (25)Mg-MIE degree and the Mt[Fe(2+)] values was found. The physical and biophysical mechanisms behind these phenomena, as well as the possible impact of these data on further biochemical and pharmacological studies involving (25)Mg-promoted nuclear spin selectivity in mitochondrial function, are under discussion.
authors.affiliation: Department of Life Sciences, Moscow Region Pedagogical University, Orekhovo-Zouyevo, Moscow Provivce, Russia.
authors.forename: Oleg A
authors.initials: OA
authors.lastname: Shatalov
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Svistunov
authors.forename: Yuri K
authors.initials: YK
authors.lastname: Napolov
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Bukhvostov
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Kuznetsov
authors.forename: Renad N
authors.initials: RN
authors.lastname: Alyautdin
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis* / Q000378:metabolism; D000818:Animals; D007554:Isotopes; D008274:Magnesium / Q000502:physiology*; D059346:Magnets; D008297:Male; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D009928:Organ Specificity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007554:Isotopes; D000255:Adenosine Triphosphate; D008274:Magnesium