title: The influence of bone marrow aspirates and concentrates on the early volume stability of maxillary sinus grafts with deproteinized bovine bone mineral - first results of a RCT.
abstract: OBJECTIVE
  The aim of the study was to investigate whether bone marrow aspirates (BMA) and concentrates (BMAC) influence the grafts' stability when added to deproteinized bovine bone mineral (DBBM) within the first 6 months after maxillary sinus augmentation.
  
  
  METHODS
  26 CT data of 13 patients undergoing bilateral maxillary sinus augmentation in a split-mouth design were evaluated using the Voxim software by comparing the graft volumes 2 weeks after the sinus lift procedure with CT data obtained 6 months later. DBBM with (N = 6) or without tibial BMA (N = 6) and DBBM with (N = 7) and without adding iliac BMAC (N = 7) were used as grafts. Absolute and percentage changes in the graft volumes were evaluated, and the nonparametric Mann-Whitney U-test and the nonparametric Wilcoxon test were performed to determine significant differences between the graft volumes within each single split-mouth group and between the two groups.
  
  
  RESULTS
  Overall, the volumes decreased between 15% and 21%. All single groups showed statistically significant decreases over 6 months of healing. The time-dependent changes in volumes between the different groups were not statistically significant (P = 0.818).
  
  
  CONCLUSIONS
  An evident decrease in graft volume over the first 6 months of healing has to be expected irrespectively of graft composite. Neither BMA nor BMAC seem to have an evident impact. Overaugmentation seems recommendable in two-stage maxillary sinus surgery.
authors.affiliation: Department of Oral Surgery, Oral Radiology and Oral Medicine, School of Dentistry, University of Basel, Basel, Switzerland; Department of Oral Surgery and Radiology, School of Dentistry, Medical University of Graz, Graz, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Kühl
authors.forename: M
authors.initials: M
authors.lastname: Payer
authors.forename: R
authors.initials: R
authors.lastname: Kirmeier
authors.forename: A
authors.initials: A
authors.lastname: Wildburger
authors.forename: W
authors.initials: W
authors.lastname: Wegscheider
authors.forename: N
authors.initials: N
authors.lastname: Jakse
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000379:methods*; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D006801:Humans; D007085:Ilium / Q000637:transplantation; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000601:surgery; D008875:Middle Aged; D011446:Prospective Studies; D011857:Radiographic Image Interpretation, Computer-Assisted; D059546:Sinus Floor Augmentation / Q000379:methods*; D013977:Tibia / Q000637:transplantation; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: bone replacement materials; maxillary sinus floor augmentation; volume stability