title: Incidence and survival of patients with small intestinal neuroendocrine tumours in a Danish NET center.
abstract: BACKGROUND
  Small intestinal neuroendocrine tumours (NETs) have increased in incidence during the past decades. In recent years, new promising treatment modalities have been introduced. The aim of the present study was to characterize and compare patients with small intestinal NET seen in the periods 1994-2003 (group 1) and 2004-2011 (group 2) to demonstrate changes in incidence and survival in the two time periods.
  
  
  METHODS
  There were 52 NET patients in group 1 and 109 patients in group 2.
  
  
  RESULTS
  The incidence of small intestinal NET was 0.3/100.000/year in period 1 and 0.7/100.000/year in period 2. There was no difference in median chromogranin A levels (8709 versus 2381 pmol/L, P = 0.107), presence of liver metastases (56% versus 44%), clinical symptoms (flushing/diarrhea), or Ki67 index (2% versus 2%), between the two time periods. The 5-year survival rate in the two time periods was similar, 64.7%, and 77.0%, respectively, (P = 0.23).
  
  
  CONCLUSIONS
  We observed an increase in the incidence of small intestinal NET during the period from January 1994 to December 2011, but we were not able to demonstrate an improved survival during the same time period.
authors.affiliation: Department of Medicine V Hepatology and Gastroenterology, Aarhus University Hospital, 8000 Aarhus, Denmark. lisebrehmhoej@hotmail.com
authors.forename: Lise Brehm
authors.initials: LB
authors.lastname: Hoej
authors.forename: Karen Marie
authors.initials: KM
authors.lastname: Nykjær
authors.forename: Henning
authors.initials: H
authors.lastname: Gronbaek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007414:Intestinal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality*; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends