title: SAR studies on β-cell K(ATP) channel openers.
abstract: Recently Balaban has introduced a J-type G index for modeling those properties/activities where not only the "shape" but also size of the graph influences the property/activity of organic compounds acting as drugs. Here, for the first time G index has been used for modeling the pancreatic β-cell K(ATP) channel openers viz R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(substituted phenylaminocarbonylamino)-2H-1-benzopyrans. Modeling technology used in this paper has established that the referred activity is excellently modeled by using G as one of the correlating descriptors. The results are critically discussed using Ridge statistics.
authors.affiliation: Department of SHM, Amrapali Institute of Technology & Sciences, Shiksha Nagar, Lamachaur, Haldwani, 263139, Uttara Khand, India.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Singh
authors.forename: Basheerulla
authors.initials: B
authors.lastname: Shaik
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Agrawal
authors.forename: P V
authors.initials: PV
authors.lastname: Khadikar
mesh_terms: D001578:Benzopyrans / Q000737:chemistry; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008962:Models, Theoretical; D015221:Potassium Channels / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D001578:Benzopyrans; D015221:Potassium Channels