title: [The dose response decrease of lung function associated with the urinary polycyclic aromatic hydrocarbons metabolites in coke oven workers].
abstract: OBJECTIVE
  To analyze the relationship between metabolites of polycyclic aromatic hydrocarbons (PAHs) and lung function in coke oven workers, and to provide scientific basis for further exploring the potential mechanism and developing the preventing strategies of the workers' early lung damage.
  
  
  METHODS
  We measured carbon monoxide, sulfur dioxide, benzene soluble matter, particulate matters, and PAHs at different workplaces of a coke oven plant. Detailed information on demography and occupational health condition of 912 workers were collected. We divided these workers into control group and coke oven group according to their workplaces and the different concentrations of COEs in the environment. We detected 10 urinary PAH metabolites and lung function using gas chromatography-mass spectrometry and spirometric tests, respectively.
  
  
  RESULTS
  FEV(1.0) (91.12 ± 13.31) and FEV(1.0)/FVC (108.61 ± 20.37) of the coke oven group is significantly lower than the control group (94.16 ± 15.57, 113.45 ± 19.70). In the coke oven group, the hydroxyphenanthrene and 1-hydroxypyrene are negatively correlated with FEV(1.0)/FVC (β = -0.136, β = -0.100), Ptrend < 0.05 for all.
  
  
  CONCLUSIONS
  The dose response decrease of lung function is associated with the urinary PAH metabolites in coke oven workers. Indicated that the long exposure to PAHs may cause the early lung damage in coke oven workers, phenanthrene and pyrene may be the main factors.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Die
authors.initials: D
authors.lastname: Hu
authors.forename: Qi-fei
authors.initials: QF
authors.lastname: Deng
authors.forename: Su-li
authors.initials: SL
authors.lastname: Huang
authors.forename: Yun-feng
authors.initials: YF
authors.lastname: He
authors.forename: Huan
authors.initials: H
authors.lastname: Guo
authors.forename: Tang-chun
authors.initials: TC
authors.lastname: Wu
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000652:urine*; D003077:Coke; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis; D010616:Phenanthrenes / Q000652:urine; D011084:Polycyclic Aromatic Hydrocarbons / Q000652:urine*; D011721:Pyrenes / Q000652:urine; D012129:Respiratory Function Tests
chemical_list: D000395:Air Pollutants, Occupational; D003077:Coke; D010616:Phenanthrenes; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; C092102:1-hydroxyphenanthrene; C033146:1-hydroxypyrene