title: Simultaneous lymph node involvement by Castleman disease and Kaposi sarcoma.
abstract: Both multicentric Castleman disease and Kaposi sarcoma are more frequently observed in HIV infected patients. The coexistence of these Human herpesvirus 8 related lesions, in the same tissue, has been observed, but literature reports are scant. On the other hand, the expression of HHV-8-LANA-1 is easily demonstrable by immunohistochemistry. This has been shown to be a powerful tool for the diagnosis of these entities. The aim of this report is to communicate our experience with a case of multicentric Castleman disease occurring in the setting of HIV infection, which demonstrated microscopic Kaposi sarcoma in the same lymph node during the pathological work-up.
authors.affiliation: Instituto de Pesquisa Clínica Evandro Chagas (IPE), Fiocruz Rio de Janeiro (RJ), Brazil.
authors.forename: Luciana Wernersbach
authors.initials: LW
authors.lastname: Pinto
authors.forename: Estevão Portela
authors.initials: EP
authors.lastname: Nunes
keywords: Adult; Case reports; Giant lymph node hyperplasia; Herpesviridae infections; Herpesvirus 8, human; Human; Male; Sarcoma, Kaposi; Virus latency