title: A simple Indian diabetes risk score could help identify nondiabetic individuals at high risk of non-alcoholic fatty liver disease (CURES-117).
abstract: OBJECTIVE
  We aim to determine whether a simple Indian diabetes risk score (IDRS) is associated with individuals with non-alcoholic fatty liver disease (NAFLD) among nondiabetic Asian Indians.
  
  
  METHODS
  Nondiabetic participants (n = 409) were selected from the Chennai Urban Rural Epidemiology Study. Mean age was 40 ± 11.9 years, mean body mass index was 23.2 ± 3.9 kg/m(2), and 224 (54.8%) were women. The IDRS was classified as high (≥60), medium (30-50), and low (<30) risk. Non-alcoholic fatty liver disease was assessed by high-resolution β mode ultrasonography. To determine the factors associated with NAFLD, a univariate analysis was first done and a stepwise logistic regression analysis was done based on the factors associated with NAFLD. Biochemical and anthropometric measurements were obtained using standardized procedures.
  
  
  RESULTS
  The overall prevalence of NAFLD was 24.7% (101/409 participants), and it was significantly higher among those with a high (30.4%) and medium IDRS (21%) compared with the low IDRS group (15.8%; trend chi square; p = .022). In stepwise logistic regression, IDRS was associated with NAFLD with an adjusted odds ratio of 1.78 (95% confidence interval 1.04-3.06), even after adjusting for potential confounders.
  
  
  CONCLUSIONS
  The IDRS can be used as the initial step to screen individuals at high risk of NAFLD in the community.
authors.affiliation: Madras Diabetes Research Foundation, Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, International Diabetes Federation Centre for Education, Gopalapuram, Chennai, India.
authors.forename: Viknesh Prabu
authors.initials: VP
authors.lastname: Anbalagan
authors.forename: Vijayachandrika
authors.initials: V
authors.lastname: Venkataraman
authors.forename: Mamilla
authors.initials: M
authors.lastname: Vamsi
authors.forename: Mohan
authors.initials: M
authors.lastname: Deepa
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Mohan
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000453:epidemiology; D015444:Exercise; D005234:Fatty Liver / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity; D010375:Pedigree; D015995:Prevalence; D012307:Risk Factors; D055105:Waist Circumference