title: Association of rs699 (M235T) polymorphism in the AGT gene with power but not endurance athlete status.
abstract: Thus far, genetic studies of the renin-angiotensin system (RAS) with respect to athletic performance or athlete status have mainly focused on the angiotensin-converting enzyme gene and its insertion/deletion polymorphism. The aim of this study was to investigate the functional rs699 (M235T) polymorphism in angiotensinogen (AGT), the second most important gene of the RAS, for association with athletic status and level of performance. The study included 123 endurance athletes and 100 power-oriented athletes, who were classified as elite or sub-elite according to competitive achievements at the international level, and 354 unrelated sedentary control subjects. The M235T genotype and allele distributions differed significantly between power and endurance athletes (p < 0.0001 and p < 0.0002, genotypes and alleles, respectively) and between power athletes and control subjects (p < 0.0001 and p < 0.0002, genotypes and alleles, respectively). The frequency of the CC genotype in the power athlete group was 2.2 times higher and 3.1 times higher than in the control and endurance groups, respectively. No difference was found in M235T allele distribution between elite and sub-elite athletes, either in power- or endurance-oriented athletes. We conclude that the CC genotype of the M235T polymorphism is overrepresented in Polish power athletes, suggesting that the AGT M235T variant is associated with power athletes' status.
authors.affiliation: 1Department of Sport Education, Academy of Physical Education and Sport, Gdańsk, Poland 2Department Physical Culture and Health Promotion, University of Szczecin, Szczecin, Poland 3Department of Physical Education and Sport, West Pomeranian Technological Univeristy, Szczecin, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Zarębska
authors.forename: Stanisław
authors.initials: S
authors.lastname: Sawczyn
authors.forename: Mariusz
authors.initials: M
authors.lastname: Kaczmarczyk
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Ficek
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Maciejewska-Karłowska
authors.forename: Marek
authors.initials: M
authors.lastname: Sawczuk
authors.forename: Agata
authors.initials: A
authors.lastname: Leońska-Duniec
authors.forename: Jerzy
authors.initials: J
authors.lastname: Eider
authors.forename: Agata
authors.initials: A
authors.lastname: Grenda
authors.forename: Paweł
authors.initials: P
authors.lastname: Cięszczyk
mesh_terms: D000328:Adult; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D056352:Athletes; D054874:Athletic Performance / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000235:genetics*; D011044:Poland; D011110:Polymorphism, Genetic
chemical_list: C534931:AGT protein, human; D000808:Angiotensinogen