title: The marriage of cytology and cytogenetics.
abstract: The past 20 years have witnessed extraordinary advances in the field of cytogenetics, with the discovery that a multitude of neoplasms is characterized by identifiable chromosomal changes. The ability of Cytogenetics to aid in the identification and precise classification of a variety of neoplasms has not gone unnoticed by Cytology. In particular, Cytology has recognized Cytogenetics as a welcome companion in the evaluation of soft tissue tumors, lymphomas, renal and urothelial tumors, and mesothelioma. This relationship requires a good understanding of the proper handling of specimens for optimal evaluation by Cytogenetics. The marriage of Cytology and Cytogenetics will likely grow stronger as more solid tumors (eg, salivary gland neoplasms) are discovered that harbor characteristic chromosomal abnormalities.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. pdalcin@partners.org
authors.forename: Paola
authors.initials: P
authors.lastname: Dal Cin
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Qian
authors.forename: Edmund S
authors.initials: ES
authors.lastname: Cibas
mesh_terms: D003581:Cytodiagnosis; D003582:Cytogenetics; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics*