title: Association between the GRM7 rs3792452 polymorphism and attention deficit hyperacitiveity disorder in a Korean sample.
abstract: BACKGROUND
  The purpose of this study was to investigate the association between the ionotropic and glutamate receptors, N-methyl D-asparate 2A (GRIN2A) and 2B (GRIN2B), and the metabotropic glutamate receptor mGluR7 (GRM7) gene polymorphisms and attention-deficit hyperactivity disorder (ADHD) in Korean population.
  
  
  METHODS
  We conducted a case-control analysis of 202 ADHD subjects and 159 controls, performed a transmission disequilibrium test (TDT) on 149 trios, and compared scores from the continuous performance test (CPT), the Children's Depression Inventory (CDI), and the State-Trait Anxiety Inventory for Children (STAIC) according to the genotype of the glutamate receptor genes.
  
  
  RESULTS
  There were no significant differences in the genotype or allele frequencies of the GRIN2A rs8049651, GRIN2B rs2284411, or GRM7 rs37952452 polymorphisms between the ADHD and control groups. For 148 ADHD trios, the TDT analysis also showed no preferential transmission of the GRIN2A rs8049651 or GRIN2B rs2284411 polymorphisms. However, the TDT analysis of the GRM7 rs3792452 polymorphism showed biased transmission of the G allele (χ2 = 4.67, p = 0.031). In the ADHD probands, the subjects with GG genotype in the GRM7 rs37952452 polymorphism had higher mean T-scores for omission errors on the CPT than did those with the GA or AA genotype (t = 3.38, p = 0.001). In addition, the ADHD subjects who were homozygous for the G allele in the GRM7 rs37952452 polymorphism had higher STAIC-T (t = 5.52, p < 0.001) and STAIC-S (t = 2.74, p = 0.007) scores than did those with the GA or AA genotype.
  
  
  CONCLUSIONS
  These results provide preliminary evidence of an association between the GRM7 rs37952452 polymorphism and selective attention deficit and anxiety found within the Korean ADHD population.
authors.affiliation: Department of Child and Adolescent Psychiatry, Seoul National University Hospital, Seoul, Korea.
authors.forename: Subin
authors.initials: S
authors.lastname: Park
authors.forename: Sun-Woo
authors.initials: SW
authors.lastname: Jung
authors.forename: Boong-Nyun
authors.initials: BN
authors.lastname: Kim
authors.forename: Soo-Churl
authors.initials: SC
authors.lastname: Cho
authors.forename: Min-Sup
authors.initials: MS
authors.lastname: Shin
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Hee Jeong
authors.initials: HJ
authors.lastname: Yoo
authors.forename: Dae-Yeon
authors.initials: DY
authors.lastname: Cho
authors.forename: Un-Sun
authors.initials: US
authors.lastname: Chung
authors.forename: Jung-Woo
authors.initials: JW
authors.lastname: Son
authors.forename: Hyo-Won
authors.initials: HW
authors.lastname: Kim
mesh_terms: D000342:Affective Symptoms / Q000150:complications / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D002648:Child; D003627:Data Interpretation, Statistical; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D018698:Glutamic Acid / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D060888:Real-Time Polymerase Chain Reaction; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014888:Wechsler Scales
chemical_list: D018094:Receptors, Metabotropic Glutamate; C102719:metabotropic glutamate receptor 7; D018698:Glutamic Acid