title: Serine protease and ovarian paracrine factors in regulation of ovulation.
abstract: The controlled target extracellular matrix (ECM) degradation generated by serine protease and regulated by serine protease inhibitor and ovarian paracrine/autocrine factors is an event that affects a wide variety of physiological and pathological processes in the ovary. Evidence cumulated in the past decade clearly showed that the hormone-induced coordinated expression of the tissue-type PA (tPA) produced mainly by granulosa cells and oocyte, and its inhibitor PAI-1 secreted by theca cells in the preovulatory follicles may be responsible for a controlled and directed proteolysis leading to the rupture of selected follicles in the rat, monkey and other mammals. In recent years increasing evidence further demonstrated that oocyte maturation and ovulation may also be modulated by other serine protease and inhibitor, as well as endogenously- produced ovarian paracrine/autocrine factors. Thus, it is important to identify the interrelationship between the serine protease system and the multiple factors, and to know how they regulate the ovarian physiological and pathological processes during oocyte maturation and ovulation.
authors.affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Yi-Xun
authors.initials: YX
authors.lastname: Liu
authors.forename: Xi-Ming
authors.initials: XM
authors.lastname: Liu
authors.forename: Liang-Fang
authors.initials: LF
authors.lastname: Nin
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Su-Ren
authors.initials: SR
authors.lastname: Chen
mesh_terms: D000818:Animals; D066246:ErbB Receptors / Q000096:biosynthesis; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006107:Granulosa Cells / Q000378:metabolism; D008253:Macaca mulatta; D020782:Matrix Metalloproteinases / Q000502:physiology; D051379:Mice; D009865:Oocytes / Q000502:physiology*; D010053:Ovary / Q000378:metabolism; D010060:Ovulation / Q000187:drug effects / Q000502:physiology*; D019899:Paracrine Communication / Q000502:physiology*; D017395:Plasminogen Activator Inhibitor 1 / Q000096:biosynthesis; D010960:Plasminogen Activators / Q000502:physiology; D011374:Progesterone / Q000502:physiology; D051381:Rats; D011980:Receptors, Progesterone / Q000502:physiology; D012697:Serine Endopeptidases / Q000378:metabolism*; D058258:Serpin E2 / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D010959:Tissue Plasminogen Activator / Q000378:metabolism
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D011980:Receptors, Progesterone; D058258:Serpin E2; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D005640:Follicle Stimulating Hormone; D066246:ErbB Receptors; D010960:Plasminogen Activators; D012697:Serine Endopeptidases; D010959:Tissue Plasminogen Activator; D020782:Matrix Metalloproteinases