title: Vitamin D and type 2 diabetes mellitus (D2).
abstract: Based on increasing evidence from animal and human studies, vitamin D deficiency is now regarded as a potential risk factor for Type 2 diabetes mellitus (T2DM). Vitamin D is involved in the pathogenesis of pancreatic β-cell dysfunction, insulin resistance, and systemic inflammation, conditions that contribute to the development of T2DM. Vitamin D can affect the progress of this disease directly through the activation of its own receptor, and indirectly via the regulation of calcium homeostasis. Observational studies have revealed the association between vitamin D deficiency and incident T2DM. More double-blind randomized control studies that investigate the effects of vitamin D supplementation on insulin sensitivity, insulin secretion, and the occurrence of T2DM are needed.
authors.affiliation: Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xuan
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Zhao
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Liu
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology*; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000503:physiopathology*; D014815:Vitamins / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D018167:Receptors, Calcitriol; D014815:Vitamins; D014807:Vitamin D; D002118:Calcium
keywords: Type 2 diabetes mellitus; insulin resistance; vitamin D; 胰岛素抵抗，2型糖尿病，维生素 D