title: First one-pot organocatalytic synthesis of α-methylene-γ-lactones.
abstract: All in one pot: an organocatalytic highly enantioselective synthesis of α-methylene-γ-lactones has been reported. The reaction between protected 2-hydroxymalonates and MBH carbonates is simply catalysed by chiral Lewis bases affording after acid treatment the corresponding lactones in excellent yields and enantioselectivities.
authors.affiliation: Organic Chemistry, University of Barcelona, Marti I Franques 1-11 08028, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Companyó
authors.forename: Andrea
authors.initials: A
authors.lastname: Mazzanti
authors.forename: Albert
authors.initials: A
authors.lastname: Moyano
authors.forename: Anna
authors.initials: A
authors.lastname: Janecka
authors.forename: Ramon
authors.initials: R
authors.lastname: Rios
mesh_terms: D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D061565:Cycloaddition Reaction; D018922:HL-60 Cells; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D058115:Lewis Bases / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002254:Carbonates; D007783:Lactones; D058115:Lewis Bases; C416683:methylene-lactone