title: Evaluation of mucoadhesive potential of gum cordia, an anionic polysaccharide.
abstract: The study involves mucoadhesive evaluation by formulating buccal discs using fluconazole as the model drug. The effect of compression pressure and gum cordia/lactose ratio on the ex vivo bioadhesion time and in vitro release of fluconazole was optimized using central composite experimental design. It was observed that the response ex vivo bioadhesion time was affected significantly by the proportion of gum cordia in the buccal discs while the in vitro release of fluconazole from the buccal discs was influenced significantly by the compression pressure. The optimized batch of buccal discs comprised of gum cordia/lactose - 0.66, fluconazole - 20 mg and was compressed at the pressure of 6600 kg. Further, it provided the ex vivo bioadhesion of 22 h and in vitro release of 80% in 24h. In conclusion, gum cordia is a promising bucoadhesive polymer.
authors.affiliation: Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, India.
authors.forename: Munish
authors.initials: M
authors.lastname: Ahuja
authors.forename: Suresh
authors.initials: S
authors.lastname: Kumar
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000268:Adhesiveness; D000278:Administration, Buccal; D000838:Anions / Q000737:chemistry; D031213:Cordia / Q000737:chemistry*; D015725:Fluconazole / Q000008:administration & dosage / Q000737:chemistry; D007785:Lactose / Q000008:administration & dosage / Q000737:chemistry; D009061:Mouth Mucosa; D010936:Plant Extracts; D053149:Plant Gums / Q000737:chemistry*; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry*; D015203:Reproducibility of Results
chemical_list: D000838:Anions; D010936:Plant Extracts; D053149:Plant Gums; D011134:Polysaccharides; D015725:Fluconazole; D007785:Lactose