title: [Effect of perioperative glucose-insulin-potassium infusions on the prognosis in patients undergoing coronary artery bypass grafting: a meta-analysis].
abstract: OBJECTIVE
  To assess the effect of perioperative glucose-insulin-potassium (GIK) infusions on the prognosis in patients undergoing coronary artery bypass grafting.
  
  
  METHODS
  Electronic databases including Cochrane library (Issue 3, 2011), Pubmed, EMbase, Highwire, CBM and CNKI were searched. A meta-analysis of all randomized controlled trials (RCTs) comparing GIK with control in coronary artery bypass grafting was performed. Study selection and meta-analysis were conducted which according to the Cochrane Handbook for systematic reviews. Date were extracted from these trials by 3 reviewers independently and analyzed by RevMan5.0 software.
  
  
  RESULTS
  A total of 9 RCTs including 1029 patients were assessed in this study. GIK infusion was associated with significantly fewer perioperative myocardial infarctions (RR = 0.59, 95%CI: 0.38 - 0.91, P = 0.02), less inotropic support requirement (RR = 0.44, 95%CI: 0.35 - 0.56, P < 0.01), and increase the incidence of postoperative atrial fibrillation (RR = 1.23, 95%CI: 1.05 - 1.43, P = 0.009).
  
  
  CONCLUSIONS
  GIK significantly reduces myocardial injury and improves cardiac function in patients undergoing coronary artery bypass grafting, but also increases the incidence of postoperative atrial fibrillation.
authors.affiliation: Department of Anesthesiology, The First Teaching Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Liang
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
authors.forename: Chun-ling
authors.initials: CL
authors.lastname: Chen
authors.forename: Hai
authors.initials: H
authors.lastname: Guo
mesh_terms: D001026:Coronary Artery Bypass; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D009203:Myocardial Infarction / Q000517:prevention & control; D011184:Postoperative Period; D011188:Potassium / Q000008:administration & dosage*; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic
chemical_list: D007328:Insulin; D005947:Glucose; D011188:Potassium