title: Regulation network analysis in the esophageal squamous cell carcinoma.
abstract: BACKGROUND
  The incidence of esophageal squamous cell carcinoma (ESCC) has high regional selectivity. The molecular mechanisms of ESCC are complex and involve multiple oncogenes, tumor suppressor genes, receptor tyrosine kinases, cytoplasmic enzymes, and tumor interstitial elements.
  
  
  OBJECTIVE
  Here we used bioinformatics to obtain some important genes and pathways involved in ESCC.
  
  
  METHODS
  In this article, we did Affymetrix microarray data collection from three big databases, and then selected all the differentially expressed genes (DEGs) according to some principles. On this basis, we carried out regulation network analysis and pathway enrichment analysis, obtaining ESCC related regulation network analysis, after which we selected significant pathways on regulation network and established TF-pathway regulation network.
  
  
  RESULTS
  In the transcription factors (TFs) regulation network we found SP1, E2F1, USF2 and SP3 form a local network which suggested that these TFs might play a more important role in ESCC. Some key pathways were also identified, such as P53 signaling pathway, melanoma and prostate cancer pathways.
  
  
  CONCLUSIONS
  The identification of crucial molecular pathways involved in ESCC would ultimately improve therapeutic effects and facilitate the development of new treatment strategies.
authors.affiliation: Department of Thoracic Surgery, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: J
authors.initials: J
authors.lastname: Xiang
authors.forename: W
authors.initials: W
authors.lastname: Zang
authors.forename: J
authors.initials: J
authors.lastname: Che
authors.forename: K
authors.initials: K
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Hang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics*; D019295:Computational Biology; D004938:Esophageal Neoplasms / Q000209:etiology / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics
chemical_list: D014157:Transcription Factors