title: No association between ovarian cancer susceptibility variants and breast cancer risk among Chinese women.
abstract: BACKGROUND
  As breast and ovarian cancers may have similar etiologies, this study aimed to evaluate the hypothesis that breast cancer shares common genetic susceptibility variants with ovarian cancer.
  
  
  METHODS
  Ten genetic variants in nine loci were previously identified to be associated with ovarian cancer risk among Caucasian women; an additional 353 variants in high-linkage disequilibrium (r(2) ≥ 0.6) among Han Chinese were identified. Data were available from the Affymetrix Genome-Wide Array (6.0) or MACH imputation for 25 and 78 common genetic variants [minor allele frequency (MAF) ≥0.05], respectively. Associations with breast cancer risk were evaluated by additive logistic regression models among 2,918 breast cancer cases and 2,324 controls.
  
  
  RESULTS
  No associations with breast cancer risk were evident for 103 ovarian cancer susceptibility variants in five loci. Four loci were not evaluated, as they included only rare variants (MAF < 0.05).
  
  
  CONCLUSIONS
  Ovarian cancer susceptibility variants identified in Caucasian women were not associated with breast cancer risk among 5,242 Chinese women.
  
  
  CONCLUSIONS
  These findings suggest that breast and ovarian cancer may not share common susceptibility variants among Chinese women.
authors.affiliation: Alicia Beeghly-Fadiel, Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, 2525 West End Avenue, 838-A, Nashville, TN 37203, USA.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Ma
authors.forename: Qiuyin
authors.initials: Q
authors.lastname: Cai
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Delahanty
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Ben
authors.initials: B
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Jirong
authors.initials: J
authors.lastname: Long
authors.forename: Alicia
authors.initials: A
authors.lastname: Beeghly-Fadiel
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D015201:Meta-Analysis as Topic; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000209:etiology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor