title: Propofol infusion syndrome or adrenoleukodystrophy?
abstract: Following a propofol anesthetic, a 5-year-old girl with lower extremity spasticity seized and developed hypertriglyceridemia, hyperkalemia, and metabolic acidosis. A presumed diagnosis of propofol infusion syndrome (PRIS) was made, but further investigation revealed neonatal adrenoleukodystrophy. PRIS should be considered with this constellation of symptoms, but other neurometabolic disorders must always be ruled out.
authors.affiliation: Anesthesiology and Reanimation Clinic, Tepecik Research and Training Hospital, Izmir, Turkey. dr_ykaraman@hotmail.com
authors.forename: Yucel
authors.initials: Y
authors.lastname: Karaman
authors.forename: Aylin
authors.initials: A
authors.lastname: Goktay
authors.forename: Hasan
authors.initials: H
authors.lastname: Agin
authors.forename: Utku
authors.initials: U
authors.lastname: Karaarslan
mesh_terms: D000138:Acidosis / Q000150:complications; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D001784:Blood Gas Analysis; D002547:Cerebral Palsy / Q000150:complications; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D028361:Mitochondrial Diseases / Q000175:diagnosis* / Q000628:therapy; D018901:Peroxisomal Disorders / Q000175:diagnosis* / Q000628:therapy; D015742:Propofol / Q000009:adverse effects*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol