title: Exploration of biosynthetic access to the shared precursor of the fusicoccane diterpenoid family.
abstract: Herein preparative scale access to the shared precursor of the fusicoccane family of diterpenoids through biosynthesis in three different microbial hosts is reported. A method to purify the metabolite in high purity and on a preparative scale was explored.
authors.affiliation: Technische Universität Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Arens
authors.forename: Benedikt
authors.initials: B
authors.lastname: Engels
authors.forename: Stephan
authors.initials: S
authors.lastname: Klopries
authors.forename: Stefan
authors.initials: S
authors.lastname: Jennewein
authors.forename: Christian
authors.initials: C
authors.lastname: Ottmann
authors.forename: Frank
authors.initials: F
authors.lastname: Schulz
mesh_terms: D000528:Alternaria / Q000201:enzymology; D055162:Biocatalysis; D002963:Cladosporium / Q000378:metabolism; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D045782:Hemiterpenes / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry
chemical_list: D004224:Diterpenes; D005656:Fungal Proteins; D045782:Hemiterpenes; D009943:Organophosphorus Compounds; C004809:isopentenyl pyrophosphate; C043060:3,3-dimethylallyl pyrophosphate