title: Development and application of chiral crown ethers as selectors for chiral separation in high-performance liquid chromatography and nuclear magnetic resonance spectroscopy.
abstract: Chiral crown ethers have been widely used in the resolution of various chiral compounds containing a primary amino group. Covalently bonded chiral stationary phases derived from (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) were developed in our groups and utilized for the resolution for several types of analytes. By use of NMR spectroscopy, chiral discrimination studies were performed for α-amino acids and their esters using 18-C-6-TA. Here, advances in the development and application of chiral stationary phases and chiral solvating agents using 18-C-6-TA for enantiomer resolution are described in relationship to recent chiral recognition mechanism studies.
authors.affiliation: College of Pharmacy, Sunchon National University, Sunchon, Jeonnam, 540-950, Republic of Korea.
authors.forename: Man-Jeong
authors.initials: MJ
authors.lastname: Paik
authors.forename: Jong Seong
authors.initials: JS
authors.lastname: Kang
authors.forename: Bin-Syuan
authors.initials: BS
authors.lastname: Huang
authors.forename: James R
authors.initials: JR
authors.lastname: Carey
authors.forename: Wonjae
authors.initials: W
authors.lastname: Lee
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D043844:Crown Ethers / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D043844:Crown Ethers; C090732:18-crown-6 2,3,11,12-tetracarboxylic acid