title: Homozygosity mapping of depressive disorder in a large family from Pakistan: significant linkage on chromosome 6 and 9.
abstract: A large family with a high prevalence of recurrent major depression and high average inbreeding coefficient was ascertained from rural Pakistan. Subjects were interviewed and diagnosed by a trained psychiatrist, 370 microsatellite markers were genotyped and the program FEstim was used for homozygosity mapping. Significant linkage was found on Chromosome 9 and Chromosome 6 after fine mapping. These regions on Chromosome 6 and 9 may harbor genes which predispose to depression.
authors.affiliation: Tees, Esk, and Wear Valleys, NHS Foundation Trust and School of Medicine and Health, University of Durham, Durham, UK. mayub@nhs.net
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ayub
authors.forename: Muhammad
authors.initials: M
authors.lastname: Irfan
authors.forename: Alan
authors.initials: A
authors.lastname: Maclean
authors.forename: Farooq
authors.initials: F
authors.lastname: Naeem
authors.forename: Douglas
authors.initials: D
authors.lastname: Blackwood
mesh_terms: D000328:Adult; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003866:Depressive Disorder / Q000235:genetics*; D005190:Family; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010154:Pakistan