title: Comparison of the pharmacokinetics of three concentrations of insulin aspart during continuous subcutaneous insulin infusion (CSII) in a pig model.
abstract: OBJECTIVE
  The aim of the study was to investigate the pharmacokinetic properties of insulin aspart (IAsp) in three different concentrations given as a continuous subcutaneous insulin infusion (CSII).
  
  
  METHODS
  A randomized cross-over study was performed in pigs, where IAsp U200, U100 or U20 was given for 8 h with the same total dose. Six pigs were included and blood was sampled during the CSII and 3 h after.
  
  
  RESULTS
  The half-life (t(1/2) ) was 24.3 (range 17.3-41.3), 28.8 (range 19.6-54.3) and 23.6 (range 17.4-36.8) min for U200, U100 and U20, respectively. The area under the curve per dose (AUC/D) was determined to be 51.2 ± 19.5, 52.3 ± 12.5 and 51.6 ± 6.7 pm × min/kg for U200, U100 and U20, respectively. The steady state plasma concentration (C(ss) ) was 57.5 ± 27.1, 54.3 ± 10.3 and 55.1 ± 8.0 pm (mean ± SD) for U200, U100 and U20, respectively. Time to steady state (T(ss) ) was 110 ± 36, 98 ± 48 and 90 ± 27 min for U200, U100 and U20, respectively.
  
  
  CONCLUSIONS
  In conclusion, no significant difference was found in t(1/2) , AUC/D, C(ss)  or T(ss)  between the three IAsp concentrations when given at a basal rate in CSII.
authors.affiliation: Insulin Pharmacology, Histology and Delivery, Novo Nordisk A/S, Måløv, Denmark.
authors.forename: Signe Beck
authors.initials: SB
authors.lastname: Petersen
authors.forename: Flemming Seier
authors.initials: FS
authors.lastname: Nielsen
authors.forename: Ulla
authors.initials: U
authors.lastname: Ribel
authors.forename: Jeppe
authors.initials: J
authors.lastname: Sturis
authors.forename: Ole
authors.initials: O
authors.lastname: Skyggebjerg
mesh_terms: D000818:Animals; D019540:Area Under Curve; D018592:Cross-Over Studies; D005260:Female; D006207:Half-Life; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D055104:Infusions, Subcutaneous; D061267:Insulin Aspart / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D007332:Insulin Infusion Systems; D011897:Random Allocation; D013552:Swine
chemical_list: D007004:Hypoglycemic Agents; D061267:Insulin Aspart