title: The effects of a long-term physical activity intervention on serum uric acid in older adults at risk for physical disability.
abstract: Observational studies show a relationship between elevated serum uric acid (UA) and better physical performance and muscle function. The purpose of this paper was to determine whether regular participation in an exercise intervention, known to improve physical functioning, would result in increased serum UA. For this study, 424 older adults at risk for physical disability were randomized to participate in either a 12-mo moderate-intensity physical activity (PA) or a successful aging (SA) health education intervention. UA was measured at baseline, 6, and 12 mo (n = 368, 341, and 332, respectively). Baseline UA levels were 6.03 ± 1.52 mg/dl and 5.94 ± 1.55 mg/dl in the PA and SA groups, respectively. The adjusted mean UA at month 12 was 4.8% (0.24 mg/dl) higher in the PA compared with the SA group (p = .028). Compared with a health education intervention, a 1-yr PA intervention results in a modest increase in systemic concentration of UA in older adults at risk for mobility disability.
authors.affiliation: Dept. of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Beavers
authors.forename: Fang-Chi
authors.initials: FC
authors.lastname: Hsu
authors.forename: Monica C
authors.initials: MC
authors.lastname: Serra
authors.forename: Veronica
authors.initials: V
authors.lastname: Yank
authors.forename: Marco
authors.initials: M
authors.lastname: Pahor
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Nicklas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D001837:Body Weights and Measures; D015444:Exercise / Q000502:physiology / Q000523:psychology; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D015577:Geriatric Assessment; D015438:Health Behavior; D006266:Health Education / Q000379:methods; D006801:Humans; D057187:Independent Living / Q000523:psychology; D008297:Male; D051346:Mobility Limitation; D008991:Monitoring, Physiologic; D009043:Motor Activity / Q000502:physiology*; D017063:Outcome Assessment, Health Care; D057185:Sedentary Behavior; D014527:Uric Acid / Q000378:metabolism*
chemical_list: D014527:Uric Acid