title: [Studies on the risks of cardia neoplasm among immediate relatives of the patients in Shanxi province].
abstract: OBJECTIVE
  To analyze the different risks of cardia neoplasms in the immediate relatives of the cardia cancer patients, through a case-control study.
  
  
  METHODS
  A case-control study was adopted on 772 cases and 772 controls, and relative risk (RR) were measured to compare the results from paternal or matrilineal groups.
  
  
  RESULTS
  (1) Risk of the 1st grade kinship to the male cardia-cancer-patient group was obviously higher than that of the control group with RR = 2.61 (95%CI: 1.44 - 4.73, P < 0.01). (2) The risks of both paternal (P < 0.05) and matrilineal (P < 0.05) in the male cardia-cancer-patients were obviously higher than that of the control groups while the risk of those male cardia-cancer-patients in the paternal was higher than that of the control group (P < 0.05), so as the case for female patients in the matrilineal group (P < 0.05). (3) Data from the 1st grade kinship of cardia-cancer-patient group showed that parents and siblings had a higher risk than the control group (P < 0.05). (4) No significant genetic differences were found between the paternal of either the cancer group or the control group (P > 0.05), but statistical difference was observed that the risk of someone being the matrilineal of the cancer group was higher than that of the control group (P < 0.05).
  
  
  CONCLUSIONS
  The risks of cardia-cancer were higher in the 1st grade kinship, which including parents, brothers, sisters, maternal grandmother, mother, and maternal aunt. It was suggested that prevention programs should be focused on both earlier detection and treatment of the patients. New strategy for cancer prevention also need to be further developed.
authors.affiliation: Shanxi Provincial Tumor Hospital, Taiyuan, China. zmkt_z@yeah.net
authors.forename: Guo-ping
authors.initials: GP
authors.lastname: Wang
authors.forename: Xiao-you
authors.initials: XY
authors.lastname: Han
authors.forename: Ti
authors.initials: T
authors.lastname: Ding
authors.forename: Wen
authors.initials: W
authors.lastname: Su
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Li
authors.forename: Ze-feng
authors.initials: ZF
authors.lastname: Gao
mesh_terms: D000368:Aged; D002299:Cardia / Q000473:pathology*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010290:Parents; D015995:Prevalence; D012307:Risk Factors; D035781:Siblings; D013274:Stomach Neoplasms / Q000453:epidemiology*