title: Low-resolution structural modeling of protein interactome.
abstract: Structural characterization of protein-protein interactions across the broad spectrum of scales is key to our understanding of life at the molecular level. Low-resolution approach to protein interactions is needed for modeling large interaction networks, given the significant level of uncertainties in large biomolecular systems and the high-throughput nature of the task. Since only a fraction of protein structures in interactome are determined experimentally, protein docking approaches are increasingly focusing on modeled proteins. Current rapid advancement of template-based modeling of protein-protein complexes is following a long standing trend in structure prediction of individual proteins. Protein-protein templates are already available for almost all interactions of structurally characterized proteins, and about one third of such templates are likely correct.
authors.affiliation: Center for Bioinformatics, The University of Kansas, Lawrence, KS 66047, USA. vakser@ku.edu
authors.forename: Ilya A
authors.initials: IA
authors.lastname: Vakser
mesh_terms: D008958:Models, Molecular; D062105:Molecular Docking Simulation; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D020543:Proteome
chemical_list: D011506:Proteins; D020543:Proteome