title: [Effect of combined administration of bile duct decompression and lactulose in mechanical jaundice].
abstract: OBJECTIVE
  Study the state of intestine microecology in patients with obstructive jaundice after decompression of bile ducts and administration of lactulose.
  
  
  METHODS
  58 patients of different gender and age who were under treatment in the 13th surgical department of City Clinical Hospital No. 7 due to obstructive jaundice were examined. Evaluation of lactulose administration was carried out in a blinded randomized study. The patients were divided into 2 groups of 29 individuals each: (1) patients who had undergone surgery without administration oflactulose (control) and (2) patients who had received immediately after decompression of bile ducts 30 ml of lactulose for 1 week (comparison group). Feces samples were obtained with a weekly interval for bacteriological study for dysbacteriosis.
  
  
  RESULTS
  Based on the results of bacteriological analysis of feces in all the 58 patients with mechanical jaundice disorders of intestine microecology of various severity degrees were detected. In the patient group who had received lactulose for 7 days after the decompression ofbile ducts a tendency for an increase ofpopulation level of bifidobacteria and lactobacilli and a decrease of quantity of opportunistic microorganisms of various taxonomical groups was noted.
  
  
  CONCLUSIONS
  Administration of lactulose to patients at 30 ml dose per day for 7 days positively affected the state of microbiocenosis of colon towards its normalization.
authors.forename: I B
authors.initials: IB
authors.lastname: Rabaev
authors.forename: S A
authors.initials: SA
authors.lastname: Bekbaurov
authors.forename: S V
authors.initials: SV
authors.lastname: Fialkina
mesh_terms: D000328:Adult; D058491:Bacterial Load; D001644:Bifidobacterium / Q000502:physiology; D001652:Bile Ducts / Q000187:drug effects / Q000382:microbiology / Q000473:pathology / Q000601:surgery*; D002779:Cholestasis / Q000382:microbiology / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D003106:Colon / Q000187:drug effects / Q000382:microbiology*; D003131:Combined Modality Therapy; D019299:Decompression, Surgical; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D041781:Jaundice, Obstructive / Q000382:microbiology / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D007778:Lactobacillus / Q000502:physiology; D007792:Lactulose / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D059013:Microbial Consortia / Q000502:physiology; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D007792:Lactulose