title: Physiological effect of a probiotic on skin.
abstract: OBJECTIVE
  Normal human skin can produce a range of antimicrobial chemicals that play an important part in eliminating potential cutaneous pathogens. Lactobacillus plantarum is a gram-positive bacteria that produces antimicrobial peptides, which when applied to the skin can act like an anti-inflammatory as well as enhance the antimicrobial properties of the skin. Clinical studies were conducted to determine the effect of lactobacillus extract on improvement of skin barrier and reduction of erythema from chemical irritant, skin microflora, and acne. Results show that lactobacillus extract was effective in reducing skin erythema, repairing skin barrier, and reducing skin microflora, thereby exhibiting an effective reduction in acne lesion size and erythema at 5%, but not at 1%.
  
  
  CONCLUSIONS
  Based on the results of these studies, lactobacillus extract (5%) can be used to treat mild acne lesions.
authors.affiliation: Estee Lauder Companies, New York, NY 10153, USA. nmuizzud@estee.com
authors.forename: Neelam
authors.initials: N
authors.lastname: Muizzuddin
authors.forename: Wanda
authors.initials: W
authors.lastname: Maher
authors.forename: Michael
authors.initials: M
authors.lastname: Sullivan
authors.forename: Steven
authors.initials: S
authors.lastname: Schnittger
authors.forename: Thomas
authors.initials: T
authors.lastname: Mammone
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000279:Administration, Cutaneous; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D058491:Bacterial Load; D001692:Biological Transport / Q000187:drug effects; D045424:Complex Mixtures / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D048191:Lactiplantibacillus plantarum / Q000737:chemistry*; D008297:Male; D019936:Probiotics / Q000737:chemistry*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D012882:Skin Tests; D014260:Triclosan / Q000494:pharmacology; D014867:Water / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D045424:Complex Mixtures; D014867:Water; D014260:Triclosan