title: Ginseng in the treatment of fatigue in multiple sclerosis: a randomized, placebo-controlled, double-blind pilot study.
abstract: BACKGROUND
  Fatigue is one of the common complaints of multiple sclerosis (MS) patients, and its treatment is relatively unclear. Ginseng is one of the herbal medicines possessing antifatigue properties, and its administration in MS for such a purpose has been scarcely evaluated. The purpose of this study was to evaluate the efficacy and safety of ginseng in the treatment of fatigue and the quality of life of MS patients.
  
  
  METHODS
  Eligible female MS patients were randomized in a double-blind manner, to receive 250-mg ginseng or placebo twice daily over 3 months. Outcome measures included the Modified Fatigue Impact Scale (MFIS) and the Iranian version of the Multiple Sclerosis Quality Of Life Questionnaire (MSQOL-54). The questionnaires were used after randomization, and again at the end of the study.
  
  
  RESULTS
  Of 60 patients who were enrolled in the study, 52 (86%) subjects completed the trial with good drug tolerance. Statistical analysis showed better effects for ginseng than the placebo as regards MFIS (p = 0.046) and MSQOL (p ≤ 0.0001) after 3 months. No serious adverse events were observed during follow-up.
  
  
  CONCLUSIONS
  This study indicates that 3-month ginseng treatment can reduce fatigue and has a significant positive effect on quality of life. Ginseng is probably a good candidate for the relief of MS-related fatigue. Further studies are needed to shed light on the efficacy of ginseng in this field.
authors.affiliation: Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Etemadifar
authors.forename: Farnaz
authors.initials: F
authors.lastname: Sayahi
authors.forename: Seyed-Hossein
authors.initials: SH
authors.lastname: Abtahi
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Shemshaki
authors.forename: Gholam-Ali
authors.initials: GA
authors.lastname: Dorooshi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Goodarzi
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Akbari
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Fereidan-Esfahani
mesh_terms: D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D005221:Fatigue / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications*; D005894:Panax / Q000009:adverse effects; D010865:Pilot Projects; D011788:Quality of Life
chemical_list: D004365:Drugs, Chinese Herbal