title: Short interfering RNA and the central nervous system: development of nonviral delivery systems.
abstract: The development of gene silencing therapies for neurological diseases has placed great importance on the delivery of short interfering RNA (siRNA) to the central nervous system (CNS). However, delivery of siRNA to neurons, glia and brain capillary endothelial cells (BCECs) has not been well established. This editorial describes different approaches that are being used to efficiently deliver siRNA to the CNS via intravenous, intracerebroventricular, or intranasal administration.
authors.affiliation: Tokyo Medical and Dental University, Graduate School, Department of Neurology and Neurological Science, Tokyo 113-8519, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Nishina
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Mizusawa
authors.forename: Takanori
authors.initials: T
authors.lastname: Yokota
mesh_terms: D000281:Administration, Intranasal; D061605:Administration, Intravenous; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D016503:Drug Delivery Systems; D006801:Humans; D057967:Infusions, Intraventricular; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000235:genetics
chemical_list: D034741:RNA, Small Interfering