title: [The role of purine receptors of thrombocytes in regulation of hemostasis].
abstract: The article discusses the role of ADP and ATP and their receptors in regulation of functional state of thrombocytes, maintenance of vessel wall homeostasis and coordination of inflammatory reparative process. The thrombocytes carry three modes of purine receptors: P2X1 (cationic channel activated by ATP) P2Y1 and P2Y12 (associated with G-proteins and activated by ADP). The article considers intracellular mechanisms of implementation of effects of ADP and ATP in thrombocytes6 mechanisms of their desensitization, relationship with metabolism of arachidonic acid and tyrosine kinase and role in regulation of intracellular concentration of Ca2+. The data concerning polymorphism of receptors P2Y is presented. The role of this phenomenon in thrombogenesis disorders, development of pathology of cardio-vascular system and resistance to anti-thrombocyte therapy is discussed.
authors.forename: È F
authors.initials: ÈF
authors.lastname: Barinov
authors.forename: O N
authors.initials: ON
authors.lastname: Sulaeva
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D058474:Receptors, Purinergic P2X1 / Q000235:genetics / Q000378:metabolism*; D058472:Receptors, Purinergic P2Y1 / Q000235:genetics / Q000378:metabolism*; D058925:Receptors, Purinergic P2Y12 / Q000235:genetics / Q000378:metabolism*; D013927:Thrombosis / Q000097:blood / Q000378:metabolism
chemical_list: D058474:Receptors, Purinergic P2X1; D058472:Receptors, Purinergic P2Y1; D058925:Receptors, Purinergic P2Y12; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate