title: Prevalence of oral lesions of autoimmune etiology in patients with primary Sjogren's syndrome.
abstract: OBJECTIVE
  The primary objective of this study was to determine the prevalence of oral lesions of autoimmune etiology (OLAIE) in a cohort of patients with primary Sjögren's syndrome (pSS).
  
  
  METHODS
  A multi-center retrospective cohort study was conducted at the oral medicine practices of Carolinas Medical Center (CMC), Baylor College of Dentistry (BCD), and the University of Florida (UF). Each site performed a chart review of patients with well-characterized pSS. Clinical variables such as OLAIE, traumatic lesions, and medical conditions were compiled at each site. The association between clinical variables and the presence of OLAIE was then assessed for significance.
  
  
  RESULTS
  We evaluated 155 patients diagnosed with pSS. Nineteen patients with pSS (12.3%) had an OLAIE. CMC reported 11 (21.2%) patients with OLAIE, while BCD and UF reported 4 (7.3%) and 4 (8.3%), respectively. Eleven of the 19 (58%) patients with OLAIE had lichen planus, 6 (32%) had aphthous stomatitis, 1 (5%) had chronic ulcerative stomatitis, and 1 (5%) had lesions of systemic connective tissue disease by immunofluorescence.
  
  
  CONCLUSIONS
  The results of our analysis suggest that patients with pSS have a 12% prevalence of OLAIE with a wide range (7.3-21.2%) found between practices. This difference is likely related to the different screening protocols for oral dryness between sites.
authors.affiliation: Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA. kmanook@uw.edu
authors.forename: K
authors.initials: K
authors.lastname: Likar-Manookin
authors.forename: C
authors.initials: C
authors.lastname: Stewart
authors.forename: I
authors.initials: I
authors.lastname: Al-Hashimi
authors.forename: W
authors.initials: W
authors.lastname: Curtis
authors.forename: K
authors.initials: K
authors.lastname: Berg
authors.forename: K
authors.initials: K
authors.lastname: Cherian
authors.forename: P B
authors.initials: PB
authors.lastname: Lockhart
authors.forename: M T
authors.initials: MT
authors.lastname: Brennan
mesh_terms: D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000276:immunology; D002180:Candidiasis, Oral / Q000453:epidemiology; D002908:Chronic Disease; D015331:Cohort Studies; D003240:Connective Tissue Diseases / Q000453:epidemiology / Q000276:immunology; D005260:Female; D005431:Florida / Q000453:epidemiology; D005892:Gingivitis, Necrotizing Ulcerative / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D017676:Lichen Planus, Oral / Q000453:epidemiology / Q000276:immunology; D062027:Linear IgA Bullous Dermatosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000293:injuries; D009059:Mouth Diseases / Q000453:epidemiology* / Q000276:immunology; D009657:North Carolina / Q000453:epidemiology; D010391:Pemphigoid, Bullous / Q000453:epidemiology; D010392:Pemphigus / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000453:epidemiology*; D013281:Stomatitis, Aphthous / Q000453:epidemiology / Q000276:immunology; D013781:Texas / Q000453:epidemiology
keywords: Sjogren's Syndrome; lichen planus; medicine; pathology