title: Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines.
abstract: Herpesviridae is a large family of DNA viruses divided into three subfamilies: Alpha-, Beta- and Gammaherpesvirinae. The process of herpesvirus transmission is mediated by a range of proteins, one of which is glycoprotein L (gL). Based on our analysis of the solved structures of HSV2 and EBV gH/gL complexes, we propose that Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and Betaherpesvirinae UL130 originate from chemokines. Herpes simplex virus type 2 gL and human cytomegalovirus homolog (UL130) adopt a novel C chemokine-like fold, while Epstein-Barr virus gL mimics a CC chemokine structure. Hence, it is possible that gL interface with specific chemokine receptors during the transmission of Herpesviridae. We conclude that the further understanding of the function of viral chemokine-like proteins in Herpesviridae infection may lead to development of novel prophylactic and therapeutic treatment.
authors.affiliation: Laboratory of Bioinformatics and Biostatistics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, WK Roentgena 5, Warsaw, Poland. lucjan@bioinfo.pl
authors.forename: Maja
authors.initials: M
authors.lastname: Malkowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kokoszynska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Dymecka
authors.forename: Leszek
authors.initials: L
authors.lastname: Rychlewski
authors.forename: Lucjan S
authors.initials: LS
authors.lastname: Wyrwicz
mesh_terms: D018138:Alphaherpesvirinae / Q000737:chemistry* / Q000235:genetics; D000595:Amino Acid Sequence; D018141:Betaherpesvirinae / Q000737:chemistry* / Q000235:genetics; D018925:Chemokines / Q000737:chemistry* / Q000235:genetics; D019143:Evolution, Molecular; D018142:Gammaherpesvirinae / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D016415:Sequence Alignment; D014759:Viral Envelope Proteins / Q000737:chemistry* / Q000235:genetics
chemical_list: D018925:Chemokines; D014759:Viral Envelope Proteins