title: Oseltamivir analog with boron cluster modulator.
abstract: Synthesis of novel neuraminidase inhibitor -- carborane ester of oseltamivir carboxylic acid is described, and its physicochemical and spectral characteristics is provided. Surprisingly, carborane analog of oseltamivir is of an order of magnitude less active than its precursor, the corresponding ethyl ester, which is the active principle of pharmaceutical preparations used in influenza prophylactics and therapy.
authors.affiliation: Institute of Medical Biology, Polish Academy of Sciences, Łódź, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Adamska
authors.forename: Agnieszka B
authors.initials: AB
authors.lastname: Olejniczak
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zwoliński
authors.forename: Wojciech J
authors.initials: WJ
authors.lastname: Szczepek
authors.forename: Ewelina
authors.initials: E
authors.lastname: Król
authors.forename: Bogusław
authors.initials: B
authors.lastname: Szewczyk
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Grynkiewicz
authors.forename: Zbigniew J
authors.initials: ZJ
authors.lastname: Leśnikowski
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001895:Boron / Q000737:chemistry; D002460:Cell Line; D004285:Dogs; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D053139:Oseltamivir / Q000031:analogs & derivatives*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir; D009439:Neuraminidase; D001895:Boron