title: Sumo paralogs: redundancy and divergencies.
abstract: Although sharing a common conjugation pathway, SUMO1, SUMO2/3 and SUMO4 seem to play preferential roles in the cell. Recently, many regulatory mechanisms contributing to SUMO paralogs specific modification have emerged. SUMO enzymes can discriminate between SUMO paralogs at both conjugation and deconjugation levels. Moreover, many substrates possess characteristics that promote their preference for different SUMO family members. A better knowledge of the mechanisms promoting SUMO specific modification will improve our understanding of the functions of SUMO paralogs in distinct cellular pathways.
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology at the IFOM-IEO Campus, Milan, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Citro
authors.forename: Susanna
authors.initials: S
authors.lastname: Chiocca
mesh_terms: D006801:Humans; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D025841:Small Ubiquitin-Related Modifier Proteins