title: SaBer DBS: a fully programmable, rechargeable, bilateral, charge-balanced preclinical microstimulator for long-term neural stimulation.
abstract: To effectively study the mechanisms by which deep brain stimulation (DBS) produces its therapeutic benefit and to evaluate new therapeutic indications, it is vital to administer DBS over an extended period of time in awake, freely behaving animals. To date multiple preclinical stimulators have been designed and described. However, these stimulators have failed to incorporate some of the design criteria necessary to provide a system analogous to those used clinically. Here we define these design criteria and propose an improved and complete preclinical DBS system. This system is fully programmable in frequency, pulse-width and current amplitude, has a rechargeable battery and delivers biphasic, charge-balanced output to two independent electrodes. The system has been optimized for either implantation or for use externally via attachment to rodent jackets.
authors.affiliation: Departments of Neuroscience, Psychiatry and Psychology will suffice, PA 15260, USA. sam.ewing@gmail.com
authors.forename: Samuel G
authors.initials: SG
authors.lastname: Ewing
authors.forename: Bernd
authors.initials: B
authors.lastname: Porr
authors.forename: John
authors.initials: J
authors.lastname: Riddell
authors.forename: Christine
authors.initials: C
authors.lastname: Winter
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Grace
mesh_terms: D000818:Animals; D046690:Deep Brain Stimulation / Q000295:instrumentation*; D004195:Disease Models, Animal; D051381:Rats