title: Timing of the intestinal barrier closure in puppies.
abstract: As puppies are born with very low immunoglobulin concentrations, they rely on passive immune transfer from ingested colostrum to acquire a protective immunity during the first few weeks of life. The purpose of this study was to describe the timing of gut closure in canine neonates. Twenty-two Beagle puppies received 3 ml of standardized canine colostrum at 0, 4, 8, 12, 16 or 24 h after birth using a feeding tube. Blood immunoglobulins G (IgG, M and A) were assayed 0, 4 and 48 h after colostrum ingestion. IgG absorption rate was significantly affected by the time of colostrum administration, and the IgG concentrations in puppies serum 48 h after administration were significantly higher when colostrum was ingested at 0-4 h of age than at 8-12 h or 16-24 h (1.68 ± 0.4, 0.79 ± 0.07 and 0.35 ± 0.08 g/l, respectively; p < 0.001). In the canine species, gut closure seems thus to begin as early as 4-8 h after birth and to be complete at 16-24 h. Consequently, this phenomenon appears to occur earlier in puppies than in most other species.
authors.affiliation: INRA, UMR 1225, IHAP, Toulouse, France. s.chastant@envt.fr
authors.forename: S
authors.initials: S
authors.lastname: Chastant-Maillard
authors.forename: L
authors.initials: L
authors.lastname: Freyburger
authors.forename: E
authors.initials: E
authors.lastname: Marcheteau
authors.forename: S
authors.initials: S
authors.lastname: Thoumire
authors.forename: J F
authors.initials: JF
authors.lastname: Ravier
authors.forename: K
authors.initials: K
authors.lastname: Reynaud
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003126:Colostrum; D004285:Dogs / Q000254:growth & development*; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007408:Intestinal Absorption / Q000502:physiology*; D007422:Intestines / Q000254:growth & development* / Q000502:physiology*; D013997:Time Factors
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M