title: Preparation and evaluations in vitro of oxaliplatin polylactic acid nanoparticles.
abstract: The oxaliplatin nanoparticles were prepared with polylactic acid matrix, orthogonal test was applied to optimize the prescriptions, and the qualities of oxaliplatin nanoparticles were characterized by the shape, particle size, encapsulation efficiency (EE), and drug loading (DL). Oxaliplatin nanoparticle was prepared by solution replacement method. The formation of 0.25% Tween80, DMF-water 1:8 (v/v), oxaliplatin-polylactic acid 1:5 (w/w), and 20 mg/ml polylactic acid showed the suitable EE (17.4 ± 0.47%), DL (3.52 ± 0.07%). We observed the shape of oxaliplatin nanoparticles through SEM. The average size of the particles was 120.5 ± 8.7 nm, which was detected by N5 submicron particle size analyzer.
authors.affiliation: Faculty of Pharmacy, Medical College of Qingdao University, Qingdao, P.R. China.
authors.forename: Zhaoyuan
authors.initials: Z
authors.lastname: Cui
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Ju
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Wen
authors.initials: W
authors.lastname: Gao
authors.forename: Haitian
authors.initials: H
authors.lastname: Wei
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000737:chemistry*; D000077150:Oxaliplatin; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D009944:Organoplatinum Compounds; D011091:Polyesters; D011108:Polymers; D012997:Solvents; D000077150:Oxaliplatin; D019344:Lactic Acid; C033616:poly(lactide)