title: Prenatal dolichocephaly: sign of trouble? -A variant of Miller-Dieker syndrome.
abstract: Neuroimaging and molecular cytogenetics were used to ascertain the cause of disability in a case. The case was diagnosed to be a variant of Miller-Dieker syndrome (MDS). Retrospective analysis showed a prenatal scan reporting dolichocephaly. We evaluated dolichocephaly, the name associated with a nonsynostotic cause to be a physiological variant having no prognostic value, to that of a similar synostotic or secondary to a neurological disorder cause, with prognostic significance. The report confirmed early craniosynostosis in cases suspected with a neurological disorder and also on an important criterion in molecular testing strategy in cases suspected with MDS.
authors.affiliation: National Institute for Empowerment of Persons with Multiple Disabilities, Physical Medicine & Rehabilitation, ECR, Muttukadu, Kovalam Post, Chennai, India.
authors.forename: Tomy
authors.initials: T
authors.lastname: Kochuvareed Mampilly
authors.forename: George
authors.initials: G
authors.lastname: Tomy Mampilly
authors.forename: Neeradha
authors.initials: N
authors.lastname: Chandramohan
authors.forename: Murugan
authors.initials: M
authors.lastname: Velayutham
authors.forename: Jayesh
authors.initials: J
authors.lastname: Sheth
authors.forename: Frenny
authors.initials: F
authors.lastname: Sheth
authors.forename: Vijayalakshmy
authors.initials: V
authors.lastname: Janaki
mesh_terms: D001837:Body Weights and Measures; D054221:Classical Lissencephalies and Subcortical Band Heterotopias / Q000175:diagnosis*; D005260:Female; D006257:Head / Q000002:abnormalities*; D006801:Humans; D011247:Pregnancy; D016216:Ultrasonography, Prenatal