title: Epilepsy in 2012: Advances in epilepsy shed light on key questions.
abstract: Research on epilepsies in 2012 has substantially advanced our knowledge of these often devastating conditions. From important discoveries that revealed causative factors and the molecular basis of disease, to major implications for surgical decision-making, these studies set the scene for future advances in the field.
authors.affiliation: Florey Institute of Neuroscience and Mental Health and Department of Medicine, University of Melbourne, Austin Health, Burgundy Street, Victoria 3084, Melbourne, Australia. scheffer@unimelb.edu.au
authors.forename: Ingrid E
authors.initials: IE
authors.lastname: Scheffer
authors.forename: Saul A
authors.initials: SA
authors.lastname: Mullen
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004827:Epilepsy / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D009154:Mutation / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D009493:Neurosurgery / Q000639:trends; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000502:physiology
chemical_list: D000927:Anticonvulsants; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C569370:PRRT2 protein, human; C491754:AKT3 protein, human; D051057:Proto-Oncogene Proteins c-akt