title: Particulate matter containing environmentally persistent free radicals and adverse infant respiratory health effects: a review.
abstract: The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are also at significant risk for exposure. Infants are affected differently than adults due to drastic immaturities, both physiologically and immunologically, and it is becoming apparent that they represent a critically understudied population. Highlighting our work funded by the ONES award, in this review we argue the understated importance of utilizing infant models to truly understand the etiology of PM-induced predisposition to severe, persistent lung disease. We also touch upon various mechanisms of PM-mediated respiratory damage, with a focus on the emerging importance of environmentally persistent free radicals (EPFRs) ubiquitously present in combustion-derived PM. In conclusion, we briefly comment on strengths/challenges facing current PM research, while giving perspective on how we may address these challenges in the future.
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
authors.forename: Jordy
authors.initials: J
authors.lastname: Saravia
authors.forename: Greg I
authors.initials: GI
authors.lastname: Lee
authors.forename: Slawo
authors.initials: S
authors.lastname: Lomnicki
authors.forename: Barry
authors.initials: B
authors.lastname: Dellinger
authors.forename: Stephania A
authors.initials: SA
authors.lastname: Cormier
mesh_terms: D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D001249:Asthma / Q000139:chemically induced; D005609:Free Radicals / Q000032:analysis / Q000633:toxicity*; D006801:Humans; D007223:Infant; D007229:Infant Welfare; D008168:Lung / Q000187:drug effects / Q000276:immunology; D008171:Lung Diseases / Q000139:chemically induced / Q000276:immunology; D018384:Oxidative Stress; D052638:Particulate Matter / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D005609:Free Radicals; D052638:Particulate Matter