title: EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma.
abstract: Eukaryotic translation initiation factor 4E (eIF4E) is involved in integration and amplification of many carcinogenesis signals in tumors. However, it remains unclear whether eIF4E over-expresses in NPC and whether it is associated with the development of NPC. Here, we analyzed the expression state of eIF4E, c-Myc, and MMP9 in 24 nasopharyngitises and 64 nasopharyngeal carcinomas (NPC) tissues and studied the influences of eIF4E on the proliferation and cell cycle in NPC cell lines. The results indicate that eIF4E might over-express in NPC and the over-expression of eIF4E promotes NPC growth and cell cycle progression through enhancing the translational expression of c-Myc and MMP9. The finding certainly adds new knowledge in the understanding of the carcinogenesis of NPC and provides a potential molecular target for the NPC therapy and prevention.
authors.affiliation: Cancer Institute of Guangdong Medical College, No. 1 Xincheng Road, Dongguan, Guangdong Province, 523808, People's Republic of China.
authors.forename: Mengyan
authors.initials: M
authors.lastname: Wu
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Di
authors.forename: Haixian
authors.initials: H
authors.lastname: Kang
authors.forename: Hua
authors.initials: H
authors.lastname: Zeng
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.forename: Kangrong
authors.initials: K
authors.lastname: Cai
authors.forename: Tianyun
authors.initials: T
authors.lastname: Pang
authors.forename: Sen
authors.initials: S
authors.lastname: Wang
authors.forename: Yunhong
authors.initials: Y
authors.lastname: Yao
authors.forename: Xinrong
authors.initials: X
authors.lastname: Hu
mesh_terms: D015153:Blotting, Western; D002277:Carcinoma; D002453:Cell Cycle / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D039561:Eukaryotic Initiation Factor-4E / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis; D034741:RNA, Small Interfering; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014162:Transfection; D015854:Up-Regulation
chemical_list: D039561:Eukaryotic Initiation Factor-4E; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D034741:RNA, Small Interfering; D020780:Matrix Metalloproteinase 9