title: HIV status awareness, partnership dissolution and HIV transmission in generalized epidemics.
abstract: OBJECTIVE
  HIV status aware couples with at least one HIV positive partner are characterized by high separation and divorce rates. This phenomenon is often described as a corollary of couples HIV Testing and Counseling (HTC) that ought to be minimized. In this contribution, we demonstrate the implications of partnership dissolution in serodiscordant couples for the propagation of HIV.
  
  
  METHODS
  We develop a compartmental model to study epidemic outcomes of elevated partnership dissolution rates in serodiscordant couples and parameterize it with estimates from population-based data (Rakai, Uganda).
  
  
  RESULTS
  Via its effect on partnership dissolution, every percentage point increase in HIV status awareness reduces HIV incidence in monogamous populations by 0.27 percent for women and 0.63 percent for men. These effects are even larger when the assumption of monogamy can be relaxed, but are moderated by other behavior changes (e.g., increased condom use) in HIV status aware serodiscordant partnerships. When these behavior changes are taken into account, each percentage point increase in HIV status awareness reduces HIV incidence by 0.13 and 0.32 percent for women and men, respectively (assuming monogamy). The partnership dissolution effect exists because it decreases the fraction of serodiscordant couples in the population and prolongs the time that individuals spend outside partnerships.
  
  
  CONCLUSIONS
  Our model predicts that elevated partnership dissolution rates in HIV status aware serodiscordant couples reduce the spread of HIV. As a consequence, the full impact of couples HTC for HIV prevention is probably larger than recognized to date. Particularly high partnership dissolution rates in female positive serodiscordant couples contribute to the gender imbalance in HIV infections.
authors.affiliation: Office of Population Research, Princeton University, Princeton, New Jersey, United States of America. georges.reniers@lshtm.ac.uk
authors.forename: Georges
authors.initials: G
authors.lastname: Reniers
authors.forename: Benjamin
authors.initials: B
authors.lastname: Armbruster
mesh_terms: D004243:Divorce / Q000706:statistics & numerical data; D058872:Epidemics; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008393:Marriage / Q000706:statistics & numerical data; D015233:Models, Statistical; D012747:Sexual Partners