title: A new spatane diterpenoid from the cultured soft coral Sinularia leptoclados.
abstract: A new spatane diterpenoid, leptoclalin A (1), along with two previously reported known norcembranoid diterpenes (2 and 3), were isolated from a cultured soft coral Sinularia leptoclados. The structures were determined by extensive spectroscopic analyses and by comparison with the spectral data of related known compounds. Metabolite 1 is rarely found in spatane skeletons reported from soft corals. In addition, compound 1 exhibited weak cytotoxicity towards human tumor cell lines T-47 D and K-562.
authors.affiliation: Department of Superintendent, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan. a088186@mail.tsmh.org.tw
authors.forename: Tsung-Chang
authors.initials: TC
authors.lastname: Tsai
authors.forename: Yu-Jen
authors.initials: YJ
authors.lastname: Wu
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Wei-Tung
authors.initials: WT
authors.lastname: Lin
authors.forename: Yun-Sheng
authors.initials: YS
authors.lastname: Lin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D004224:Diterpenes