title: Importance of detecting multidrug resistance proteins in acute leukemia prognosis and therapy.
abstract: Multidrug resistance (MDR) is a multifactorial phenomenon and the role of these proteins in generating the MDR phenotype is controversial. With this in mind, this review compiled the current data on the role of ABCB1, ABCC1, and LRP proteins in the prognosis of hematologic neoplasms and their influence on the choice of therapy. Literature showed that the detection of these proteins, mainly ABCB1, is important in the AL prognosis. However, there is controversy regarding the methodology used for their detection. In summary, the expression and activity profiles of ABCB1, ABCC1, and LRP, proteins capable of promoting the efflux of a variety of chemotherapeutic agents from the cell cytoplasm represent one of the greatest causes of failure in AL treatment.
authors.affiliation: Programa de Pós-graduação em Farmácia, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis - SC, Brazil.
authors.forename: Ana Carolina Rabello
authors.initials: AC
authors.lastname: de Moraes
authors.forename: Caroline Klein
authors.initials: CK
authors.lastname: Maranho
authors.forename: Gabriela Schneider
authors.initials: GS
authors.lastname: Rauber
authors.forename: Maria Cláudia
authors.initials: MC
authors.lastname: Santos-Silva
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000032:analysis* / Q000378:metabolism; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis / Q000378:metabolism; D000208:Acute Disease; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000378:metabolism; D045744:Cell Line, Tumor; D006801:Humans; D007938:Leukemia / Q000378:metabolism* / Q000473:pathology; D008954:Models, Biological; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000032:analysis / Q000378:metabolism; D011379:Prognosis; D020394:Vault Ribonucleoprotein Particles / Q000032:analysis / Q000378:metabolism; D000099187:Major Vault Protein
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D014408:Biomarkers, Tumor; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein; C513055:ABCB1 protein, human; C421109:multidrug resistance-associated protein 1