title: HAART: a risk factor for development of porphyria cutanea tarda?
abstract: Porphyria cutanea tarda (PCT) is caused by inherited or acquired partial deficiency of the uroporphyrinogen-decarboxylase (Uro-D) enzyme activity. It is the most common form of porphyria. The main triggering factors to the development of porphyria cutanea tarda are alcohol, hepatitis C virus and human immunodeficiency virus. There are several reports of PCT associated with drugs, among them, antiretroviral therapy. We describe three HIV-positive patients, which showed photosensitivity as well as the emergence of tense blisters on sun-exposed areas during the use of highly active antiretroviral therapy (HAART) and discuss the possibility of PCT after the use of these drugs by those patients.
authors.affiliation: Instituto de Dermatologia Prof. Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ. f9filho@gmail.com
authors.forename: Fred
authors.initials: F
authors.lastname: Bernardes Filho
authors.forename: Maria Victória Pinto Quaresma
authors.initials: MV
authors.lastname: Santos
authors.forename: Felipe Nazareth de Matos Pinto de
authors.initials: FN
authors.lastname: Carvalho
authors.forename: Carlos Gustavo Carneiro de
authors.initials: CG
authors.lastname: Castro
authors.forename: Elisabete
authors.initials: E
authors.lastname: Dobao
authors.forename: Marcelo Rosandiski
authors.initials: MR
authors.lastname: Lyra
authors.forename: Vinícius de
authors.initials: Vd
authors.lastname: Menezes
authors.forename: José Augusto da Costa
authors.initials: JA
authors.lastname: Nery
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017119:Porphyria Cutanea Tarda / Q000139:chemically induced* / Q000175:diagnosis; D012307:Risk Factors