title: Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial.
abstract: Low seminal plasma concentrations of coenzyme Q10 (CoQ10) have been correlated with impaired sperm parameters, but the exact mechanism remains of dominating interest. This randomised, placebo-controlled study examined the effect of CoQ10 on catalase, superoxide dismutase (SOD) and F2 -isoprostanes in seminal plasma in infertile men and their relation with CoQ10 concentration. Sixty infertile men with idiopathic oligoasthenoteratozoospermia (OAT) were randomised to receive 200 mg d(-1) of CoQ10 or placebo for 3 months. 47 persons of them completed the study. Semen analysis, anthropometric measurements, diet and physical activity assessment were performed for subjects before and after treatment. Independent and paired t-test, chi-square test and ancova were compared outcomes of supplementation between two groups. CoQ10 levels increased from 44.74 ± 36.47 to 68.17 ± 42.41 ng ml(-1) following supplementation in CoQ10 (P < 0.001). CoQ10 group had higher catalase and SOD activity than the placebo group. There was a significant positive correlation between CoQ10 concentration and normal sperm morphology (P = 0.037), catalase (P = 0.041) and SOD (P < 0.001). Significant difference was shown between the mean of changes in seminal plasma 8-isoprostane in two groups (P = 0.003) after supplementation. Three-month supplementation with CoQ10 in OAT infertile men can attenuate oxidative stress in seminal plasma and improve semen parameters and antioxidant enzymes activity.
authors.affiliation: Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Nadjarzadeh
authors.forename: F
authors.initials: F
authors.lastname: Shidfar
authors.forename: N
authors.initials: N
authors.lastname: Amirjannati
authors.forename: M R
authors.initials: MR
authors.lastname: Vafa
authors.forename: S A
authors.initials: SA
authors.lastname: Motevalian
authors.forename: M R
authors.initials: MR
authors.lastname: Gohari
authors.forename: S A
authors.initials: SA
authors.lastname: Nazeri Kakhki
authors.forename: M M
authors.initials: MM
authors.lastname: Akhondi
authors.forename: M R
authors.initials: MR
authors.lastname: Sadeghi
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D015237:Dinoprost / Q000031:analogs & derivatives / Q000378:metabolism; D004311:Double-Blind Method; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D012661:Semen / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D014451:Ubiquinone; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D002374:Catalase; D013482:Superoxide Dismutase; C024989:coenzyme Q10
keywords: Antioxidant enzymes; isoprostane; male infertility; oxidative stress; ubiquinone