title: A comparative study of apoptosis in reticular and erosive oral lichen planus.
abstract: The oral lichen planus (OLP) is a chronic inflammatory disease, probably autoimmune, with different clinical forms. The most common types are the reticular and the erosive ones. Apoptosis participates in the destruction of basal keratinocytes, but its role in the perpetuation of the subepithelial lymphocytic infiltrates was not yet investigated. To evaluate the involvement of apoptosis in the epithelium and in subepithelial lymphocytic infiltrates, 15 samples of reticular and erosive OLP and 10 samples of healthy oral mucosa were collected and processed histologically. Apoptosis was quantified in the epithelium and in inflammatory cell infiltrates. TUNEL reaction was used to measure apoptosis in the infiltrates. Erosive OLP showed more intense epithelial apoptosis than reticular OLP and controls. In contrast, apoptosis in the inflammatory cell infiltrates was more frequent in reticular than in erosive OLP. Lymphocytes were the predominant cells within the inflammatory cell infiltrates and were more frequent in erosive OLP than in reticular type. These results suggest that different apoptotic levels are involved in the erosive/reticular switch in OLP, determining different clinical presentations. In conclusion, decreased apoptosis in inflammatory infiltrates may contribute to the persistence of T lymphocytes, worsening the attack to the epithelium in erosive OLP.
authors.affiliation: Department of Oral Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil. jumassote@yahoo.com.br
authors.forename: Juliana M C
authors.initials: JM
authors.lastname: Brant
authors.forename: Maria Cássia F
authors.initials: MC
authors.lastname: Aguiar
authors.forename: Helenice A M
authors.initials: HA
authors.lastname: Grandinetti
authors.forename: Luciana V
authors.initials: LV
authors.lastname: Rodrigues
authors.forename: Anilton C
authors.initials: AC
authors.lastname: Vasconcelos
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D020287:In Situ Nick-End Labeling; D017676:Lichen Planus, Oral / Q000503:physiopathology*; D008214:Lymphocytes / Q000502:physiology*; D009061:Mouth Mucosa / Q000503:physiopathology*