title: [Recent advances in pathogenesis and pathophysiology in the antiphospholipid syndrome].
abstract: Antiphospholipid syndrome (APS) is an autoimmune disorder defined by the presence of antiphospholipid antibodies in plasma of patients with vascular thrombosis and/or pregnancy morbidity. APS is considered the major cause of brain infarction in young adults and is a generally accepted cause of recurrent pregnancy loss. Antiphospholipid antibodies are a heterogeneous group of autoantibodies strongly related to the clinical manifestations of APS and with a widely recognized pathogenic role in thrombosis. In this article, recent clinical and pathophysiological advances in APS are discussed.
authors.affiliation: Department of Medicine II, Hokkaido University Graduate School of Medicine.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Horita
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D015551:Autoimmunity; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D016328:NF-kappa B; D019007:P-Selectin; D011247:Pregnancy; D011248:Pregnancy Complications; D018570:Risk Assessment; D015398:Signal Transduction; D013925:Thromboplastin; D013927:Thrombosis / Q000209:etiology; D048051:p38 Mitogen-Activated Protein Kinases
chemical_list: D017152:Antibodies, Antiphospholipid; D015415:Biomarkers; D016328:NF-kappa B; D019007:P-Selectin; D013925:Thromboplastin; D048051:p38 Mitogen-Activated Protein Kinases