title: Use of a silicon microsensor for pressure monitoring inside the wound and outcomes on healing.
abstract: OBJECTIVE
  To ascertain the extent to which pressure within a defined neck compartment could be used as predictor for wound healing.
  
  
  METHODS
  Thirty patients with various head and neck malignancies that were treated surgically, were considered prospectively. In the course of surgery a pressure microsensor was implanted into the defined neck compartment and data were collected over the first 48 hours postoperatively. Logistic regression analysis was used to determine the strength of inter fascial pressure (IP) as predictor for wound healing.
  
  
  RESULTS
  Mean IP was 7.45 ± 6.15mm Hg (95%CI 7.13; 7.77).A logistic regression model relating good/disturbed healing outcome revealed that the mean pressure is the key variable, with a major influence on healing outcome. However, this type of model only explains approximately 46% of the total variation in the responses. This implies, that although pressure change contributes significantly in explaining variations in healing, there may be other significant predictors that were not included in the study.
  
  
  CONCLUSIONS
  This study demonstrates the feasibility of IP measurement in the neck, verifies it in a human clinical experiment and highlights its potential in the prediction of wound healing complications.The study seems to suggest that for high probability of good wound healing (> 90%) the IP values should be monitored and maintained below 7mm Hg.At present, there are no comparator studies, as this kind of measurement in the neck area has not been reported yet.
authors.affiliation: University of Pardubice, Pardubice, Czech Republic. jan.mejzlik@upce.cz
authors.forename: J
authors.initials: J
authors.lastname: Mejzlik
mesh_terms: D000328:Adult; D000368:Aged; D005205:Fascia / Q000502:physiology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000503:physiopathology / Q000601:surgery; D016015:Logistic Models; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D011184:Postoperative Period; D011312:Pressure; D011446:Prospective Studies; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*