title: The effect of commonly used sutures on inflammation inducing pathogens - an in vitro study.
abstract: BACKGROUND
  Sutures are a vital part of nearly every surgical procedure designed to close and stabilize wound margins consequently allowing undisturbed wound healing.
  
  
  OBJECTIVE
  The aim of this study was to evaluate in vitro antimicrobial effect of 4 commonly used sutures.
  
  
  METHODS
  The Direct Contact Test was used to evaluate the antibacterial properties of 4 types of sutures: 2 absorbable and 2 non-absorbable braided sutures, immediately or after aging for 2 or 7 days. The tested bacteria were: Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa. Three-way ANOVA, two-way ANOVA, one-way ANOVA and Tukey multiple comparison were used for statistical analysis.
  
  
  RESULTS
  The absorbable Vicryl Plus exhibited a bactericidal effect against the Staphylococcus strains, which was unaffected by aging. With P. aeruginosa, there was only an initial delay in bacterial growth. All other tested sutures did not have antibacterial effects against any of the tested bacteria (p < 0.001).
  
  
  CONCLUSIONS
  Vicryl Plus had sustained bactericidal effect against the Staphylococcus strains but not against P. aeruginosa. None of the other sutures presented any antibacterial properties.
authors.affiliation: Department of Oral Rehabilitation, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.
authors.forename: Shlomo
authors.initials: S
authors.lastname: Matalon
authors.forename: Avital
authors.initials: A
authors.lastname: Kozlovsky
authors.forename: Anda
authors.initials: A
authors.lastname: Kfir
authors.forename: Shifra
authors.initials: S
authors.lastname: Levartovsky
authors.forename: Yardena
authors.initials: Y
authors.lastname: Mazor
authors.forename: Hagay
authors.initials: H
authors.lastname: Slutzky
mesh_terms: D020341:Absorbable Implants; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001431:Bacteriological Techniques; D001672:Biocompatible Materials / Q000494:pharmacology*; D006801:Humans; D008422:Materials Testing; D011091:Polyesters / Q000494:pharmacology; D011098:Polyglactin 910 / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D047011:Silk / Q000494:pharmacology; D012965:Sodium Chloride / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development; D013537:Sutures / Q000382:microbiology*; D013696:Temperature; D013997:Time Factors; D014260:Triclosan / Q000494:pharmacology
chemical_list: D000891:Anti-Infective Agents, Local; D001672:Biocompatible Materials; D011091:Polyesters; D047011:Silk; D011098:Polyglactin 910; D012965:Sodium Chloride; D014260:Triclosan
keywords: Absorbable sutures; Antibacterial; Non-absorbable braided sutures; Triclosan