title: Testing the effectiveness of intravitreal ranibizumab during 12 months of follow-up in venous occlusion treatment.
abstract: OBJECTIVE
  To determine the effectiveness and safety of treatment of intravitreal Ranibizumab for Central Retinal Vein Occlusion.
  
  
  METHODS
  This non-randomized observational clinical study was comprised of a round of therapy with three IVI. Twenty eyes affected by CRVO were recruited. The average age was 65.06 +/- 15 years and criterion for inclusion: age >18 years, best Corrected Visual Acuity (BCVA) from 5 to 40 letters and macular edema with thickness greater than 275 micrometer. The criteria used for reinjection were: CMT> 150 micrometer, ETDRS <10 letters and LogMAR <0.2. The statistical analysis for continuous variables (ETDRS, logMar and CMT) was conducted calculating median and range (min-max), since these variables, due to sample size, were not normally distributed.Time trends of these variables were plotted with boxplot and differences. Events between T0 and T12 were assessed using the analysis of variance (ANOVA) for repeated measurements and the F test (Pillai's trace). The statistical significance was set at p <=0.05.
  
  
  RESULTS
  All of the patients showed improvement. In fact, the ETDRS went from a median of 20.00 to 28.50, LogMAR went from a median of 0.75 to 0.55 and the values for CMT went from a median of 556.00 micrometer to 390.00 micrometer. The drug reaches maximum effectiveness after two months of therapy, with T2 remaining constant from the third injection at T3 until the end of 12 months at T12.
  
  
  CONCLUSIONS
  The results produced by our study indicate that Ranibizumab is a valid treatment for CRVO.
authors.affiliation: Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Italy. elena.pacella@uniroma1.it
authors.forename: E
authors.initials: E
authors.lastname: Pacella
authors.forename: F
authors.initials: F
authors.lastname: Pacella
authors.forename: G
authors.initials: G
authors.lastname: La Torre
authors.forename: D
authors.initials: D
authors.lastname: Impallara
authors.forename: K
authors.initials: K
authors.lastname: Malarska
authors.forename: C
authors.initials: C
authors.lastname: Brillante
authors.forename: P
authors.initials: P
authors.lastname: Turchetti
authors.forename: M
authors.initials: M
authors.lastname: De Giusti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D000069579:Ranibizumab; D012170:Retinal Vein Occlusion / Q000150:complications / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000069579:Ranibizumab