title: Accumulation of major histocompatibility complex class II(+)CD11c(-) non-lymphoid cells in the spleen during infection with Plasmodium yoelii is lymphocyte-dependent.
abstract: The spleen is the main organ for immune defense during infection with Plasmodium parasites and splenomegaly is one of the major symptoms of such infections. Using a rodent model of Plasmodium yoelii infection, MHC class II(+)CD11c(-) non-T, non-B cells in the spleen were characterized. Although the proportion of conventional dendritic cells was reduced, that of MHC II(+)CD11c(-) non-T, non-B cells increased during the course of infection. The increase in this subpopulation was dependent on the presence of lymphocytes. Experiments using Rag-2(-/-) mice with adoptively transferred normal spleen cells indicated that these cells were non-lymphoid cells; however, their accumulation in the spleen during infection with P. yoelii depended on lymphocytes. Functionally, these MHC II(+)CD11c(-) non-T, non-B cells were able to produce the proinflammatory cytokines alpha tumor necrosis factor and interleukin-6 in response to infected red blood cells, but had only a limited ability to activate antigen-specific CD4(+) T cells. This study revealed a novel interaction between MHC II(+)CD11c(-) non-lymphoid cells and lymphoid cells in the accumulations of these non-lymphoid cells in the spleen during infection with P. yoelii.
authors.affiliation: Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Rika
authors.initials: R
authors.lastname: Kamei
authors.forename: Mana
authors.initials: M
authors.lastname: Miyakoda
authors.forename: Takahiko
authors.initials: T
authors.lastname: Tamura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kimura
authors.forename: Kiri
authors.initials: K
authors.lastname: Honma
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kimura
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Yui
mesh_terms: D000818:Animals; D039521:CD11c Antigen / Q000032:analysis*; D004195:Disease Models, Animal; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D015850:Interleukin-6 / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D008288:Malaria / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010967:Plasmodium yoelii / Q000276:immunology*; D013154:Spleen / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D039521:CD11c Antigen; D000949:Histocompatibility Antigens Class II; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha