title: Intra-operative use of 5-Fluorouracil in pterygium surgery: a comparative study.
abstract: OBJECTIVE
  Evaluate the efficacy and safety of intraoperative application of 5-Fluorourail in pterygium surgery and the recurrent pterigyum postoperative.
  
  
  METHODS
  240 eyes of 120 patients with bilateral primary pterygium were operated. One hundred twenty eyes had 5-FLU (25 mg/ml) applied intraoperatively on a sponge for five minutes. One hundred twenty contralateral eyes served as controls.
  
  
  RESULTS
  After a follow-up of 90 days, 7 (5.83%) recurrences of the eyes which had 5-FLU applied intraoperatively were observed. In the control eyes, 25 (25.5%) recurrences were observed. Complications such as keratitis and lid edema were common in both groups.
  
  
  CONCLUSIONS
  This study suggests that antifibroproliferative therapy with intraoperative sponge 5-FLU is effective and safe. Its use may be a useful adjunct in primary pterygium surgery.
authors.affiliation: Reference Centre of Ophthalmology, Setor Universitário Campus I, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Salustiano Correa E Silva
authors.forename: Marcos
authors.initials: M
authors.lastname: de Pereira Avila
authors.forename: Alan Ricardo
authors.initials: AR
authors.lastname: Rassi
authors.forename: Luciana
authors.initials: L
authors.lastname: Ximenes
authors.forename: Diomario Salustiano
authors.initials: DS
authors.lastname: da Silva
authors.forename: Alcio Coutinho
authors.initials: AC
authors.lastname: de Paula
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000933:Antifibrinolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011625:Pterygium / Q000188:drug therapy / Q000517:prevention & control / Q000601:surgery*; D055502:Secondary Prevention
chemical_list: D000933:Antifibrinolytic Agents; D005472:Fluorouracil