title: Mechanisms of cardioprotection by isoflurane against I/R injury.
abstract: Myocardial infarction is responsible for most cardiovascular mortality as well as the pathogenesis of myocardial damage during and after infarction. Efforts are underway to modulate the development of ischemia-reperfusion (I-R) injury. Recently, the protective effect of isoflurane against myocardial I-R injury emerged as a possibility. Nitric oxide, nitric oxide synthases, factors related to energy metabolism, adenosine triphosphate-sensitive potassium channels, phosphatidylinositol-3-kinase and hypoxia-inducible factor1-alpha have been shown to participate in the mechanisms of cardioprotection elicited by isoflurane against I-R injury. In this review, we focus on the mechanisms of cardioprotection offered by isoflurane against I-R injury.
authors.affiliation: Department of Cardiology, First Hospital, Shanxi Medical University, Taiyuan Shanxi,030001, P. R. China. xiaoelang@yeah.net
authors.forename: Xiao-E
authors.initials: XE
authors.lastname: Lang
authors.forename: Xiong
authors.initials: X
authors.lastname: Wang
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Jin
mesh_terms: D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology; D007530:Isoflurane / Q000627:therapeutic use*; D054086:KATP Channels / Q000502:physiology; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D015221:Potassium Channels / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D043682:Receptor, Adenosine A1 / Q000502:physiology
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D054086:KATP Channels; D015221:Potassium Channels; D043682:Receptor, Adenosine A1; D007530:Isoflurane; C496319:NOS2 protein, human; C496314:NOS3 protein, human; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D011493:Protein Kinase C