title: Hemodynamic recovery after hypovolemic shock with lactated Ringer's and keratin resuscitation fluid (KRF), a novel colloid.
abstract: Death after severe hemorrhage remains an important cause of mortality in people under 50 years of age. Keratin resuscitation fluid (KRF) is a novel resuscitation solution made from keratin protein that may restore cardiovascular stability. This postulate was tested in rats that were exsanguinated to 40% of their blood volume. Test groups received either low or high volume resuscitation with either KRF or lactated Ringer's solution. KRF low volume was more effective than LR in recovering cardiac function, blood pressure and blood chemistry. Furthermore, in contrast to LR-treated rats, KRF-treated rats exhibited vital signs that resembled normal controls at 1-week.
authors.affiliation: Wake Forest University School of Medicine, Medical Center Blvd., Winston Salem , NC , USA.
authors.forename: Fiesky A
authors.initials: FA
authors.lastname: Nunez
authors.forename: Michael F
authors.initials: MF
authors.lastname: Callahan
authors.forename: Simon
authors.initials: S
authors.lastname: Trach
authors.forename: Luke R
authors.initials: LR
authors.lastname: Burnett
authors.forename: Victor
authors.initials: V
authors.lastname: Kislukhin
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Smith
authors.forename: Mark
authors.initials: M
authors.lastname: Van Dyke
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000601:surgery; D003102:Colloids / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006439:Hemodynamics; D006801:Humans; D020896:Hypovolemia / Q000601:surgery / Q000628:therapy*; D007552:Isotonic Solutions / Q000008:administration & dosage; D007633:Keratins / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D012151:Resuscitation / Q000379:methods*; D000077325:Ringer's Lactate; D014481:United States
chemical_list: D003102:Colloids; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D007633:Keratins