title: [Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging].
abstract: The decrease of lymphocyte interferon gamma expression during aging is one of the main mechanisms leading to the immunodeficiency state in the elderly. Cell penetrating geroprotective peptide Ala-Glu-Asp-Gly has the capability to activate the proliferation of lymphocytes in thymus during its aging. The nucleotide sequence which is complementary contacted with peptide Ala-Glu-Asp-Gly was found in promoter region of interferon gamma gene. Thus, the immune protection of this peptide can be explained by its activation of the interferon gamma production in T-cells.
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.forename: B I
authors.initials: BI
authors.lastname: Kuznik
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007371:Interferon-gamma / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D009842:Oligopeptides / Q000276:immunology* / Q000378:metabolism
chemical_list: D009842:Oligopeptides; D007371:Interferon-gamma; C421253:alanyl-glutamyl-aspartyl-glycine