title: Copper-catalyzed oxidative cross-coupling of H-phosphonates and amides to N-acylphosphoramidates.
abstract: A simple combination of copper(II) acetate (Cu(OAc)(2)) and an appropriate base could promote oxidative cross-coupling of H-phosphonates and amides using air as a terminal oxidant. The substrate scope was broad with respect to both dialkyl H-phosphonates and nitrogen nucleophiles (including oxazolidinone, lactam, pyrrolidinone, urea, indole, and sulfonamide derivatives), giving the corresponding P-N coupling products in moderate to high yields.
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-8656, Japan.
authors.forename: Xiongjie
authors.initials: X
authors.lastname: Jin
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Noritaka
authors.initials: N
authors.lastname: Mizuno
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry*; D058451:Oxidative Coupling
chemical_list: D000577:Amides; D063065:Organophosphonates; D003300:Copper