title: Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis.
abstract: BACKGROUND
  A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis.
  
  
  METHODS
  A case-control study was conducted among 30 patients and 90 controls.
  
  
  RESULTS
  Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease.
  
  
  CONCLUSIONS
  Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.
authors.affiliation: Laboratório de Pesquisa Clínica em Doenças Febris Agudas, Instituto de Pesquisa Clinica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ. elizabeth.neves@ipec.fiocruz.br
authors.forename: Elizabeth de Souza
authors.initials: Ede S
authors.lastname: Neves
authors.forename: André Luis Land
authors.initials: AL
authors.lastname: Curi
authors.forename: Maira Cavalcanti de
authors.initials: MC
authors.lastname: Albuquerque
authors.forename: Cassius Schnel
authors.initials: CS
authors.lastname: Palhano-Silva
authors.forename: Laura Berriel da
authors.initials: LB
authors.lastname: Silva
authors.forename: Wendy Fernandes
authors.initials: WF
authors.lastname: Bueno
authors.forename: Maria Regina Dos Reis
authors.initials: MR
authors.lastname: Amendoeira
authors.forename: Maria da Gloria
authors.initials: Mda G
authors.lastname: Bonecini-Almeida
authors.forename: Octavio
authors.initials: O
authors.lastname: Fernandes
mesh_terms: D000208:Acute Disease; D000328:Adult; D016022:Case-Control Studies; D002825:Chorioretinitis / Q000235:genetics / Q000469:parasitology*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012720:Severity of Illness Index; D014123:Toxoplasmosis / Q000235:genetics*; D014126:Toxoplasmosis, Ocular / Q000235:genetics
chemical_list: D007371:Interferon-gamma