title: Current progresses of novel natural products and their derivatives/ analogs as anti-Alzheimer candidates: an update.
abstract: Alzheimer's disease (AD) is one of the most threatening diseases affecting the aged with high incidence. Though AD has been defined for more than 100 years, it is still incurable. The drugs clinically used for the treatment of this disease, such as acetylcholinesterase inhibitors (AChEIs) and N-methyl-D-aspartate (NMDA) receptor antagonist, can only provide a limited therapeutic effect. The need of effective drugs has stimulated the search for new compounds with potential clinical utility. Natural products are rich and unexplored sources for discovering novel leading compounds. Currently, a great number of natural products have been found possessing anti-AD property counteracting different etiological factors of AD. This review will give an update demonstration on the novel anti-AD natural products and their derivatives/analogues, which have been divided into five subgroups according to their different action mechanisms: AChEIs, antioxidants, neuroprotective agents, monoamine oxidase (MAO) inhibitors, and tau hyperphosphorylation inhibitors. We put special emphasis on the findings in the past 5 years. Besides, the drug design strategy as well as the structure-activity relationship of the relevant compounds is also discussed when it is possible.
authors.affiliation: Jiangsu Province Hi-Tech Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Fang
authors.forename: Shaohua
authors.initials: S
authors.lastname: Gou
authors.forename: Xubin
authors.initials: X
authors.lastname: Fang
authors.forename: Lin
authors.initials: L
authors.lastname: Cheng
authors.forename: Christian
authors.initials: C
authors.lastname: Fleck
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D016875:tau Proteins / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001688:Biological Products; D002800:Cholinesterase Inhibitors; D008996:Monoamine Oxidase Inhibitors; D018696:Neuroprotective Agents; D016875:tau Proteins