title: The myotomal basement membrane: insight into laminin-111 function and its control by Sonic hedgehog signaling.
abstract: The importance of laminin-containing basement membranes (BM) for adult muscle function is well established, in particular due to the severe phenotype of congenital muscular dystrophies in patients with mutations disrupting the BM-muscle cell interaction. Developing muscles in the embryo are also dependent on an intact BM. However, the processes controlled by BM-muscle cell interactions in the embryo are only beginning to be elucidated. In this review, we focus on the myotomal BM to illustrate the critical role of laminin-111 in BM assembly and function at the surface of embryonic muscle cells. The myotomal BM provides also an interesting paradigm to study the complex interplay between laminins-containing BM and growth factor-mediated signaling and activity.
authors.affiliation: Department of Biomedical Science, University of Sheffield, Sheffield, UK. a.g.borycki@sheffield.ac.uk
authors.forename: Anne-Gaëlle
authors.initials: AG
authors.lastname: Borycki
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000166:cytology / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D049030:Dystroglycans / Q000378:metabolism; D004622:Embryo, Mammalian / Q000166:cytology / Q000378:metabolism; D005109:Extracellular Matrix / Q000235:genetics / Q000378:metabolism; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism*; D007797:Laminin / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism; D051787:Myogenic Regulatory Factor 5 / Q000235:genetics / Q000378:metabolism; D021381:Protein Transport; D015398:Signal Transduction; D019170:Somites / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; C486538:Dmrt2 protein, mouse; D053823:Hedgehog Proteins; D007797:Laminin; C497418:Myf5 protein, mouse; D051787:Myogenic Regulatory Factor 5; C465570:Shh protein, mouse; D014157:Transcription Factors; D049030:Dystroglycans; C084098:laminin A