title: Genomic signatures of a global fitness index in a multi-ethnic cohort of women.
abstract: The rates of obesity and sedentary lifestyle are on a dramatic incline, with associated detrimental health effects among women in particular. Although exercise prescriptions are useful for overcoming these problems, success can be hampered by differential responsiveness among individuals in cardiovascular fitness indices (i.e. improvements in strength, lipids, VO(2) max). Genomic factors appear to play an important role in determining this inter-individual variation. We performed microarray analyses on mRNA in whole blood from 60 sedentary women from a multi-ethnic cohort who underwent 12 weeks of exercise, to identify gene subsets that were differentially expressed between individuals who experienced the greatest and least improvements in fitness. We identified 43 transcripts in 39 unique genes (FDR<10%; FC>1.5) whose expression increased the most in "high" versus "low" pre-menopausal female responders. These 39 genes were enriched in six biological pathways, including oxidative phosphorylation (p = 8.08 × 10(-3)). Several of the 39 genes (i.e. TIGD7, UQCRH, PSMA6, WDR12, TFB2M, USP15) have previously reported associations with fitness-related phenotypes. In summary, we identified gene signatures based on mRNA analysis that define responsiveness to exercise in a largely minority-based female cohort. Importantly, this study validates several genes/pathways previously associated with exercise responsiveness and extends these findings with additional novel genes.
authors.affiliation: John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA. erampersaud@med.miami.edu
authors.forename: Evadnie
authors.initials: E
authors.lastname: Rampersaud
authors.forename: Lubov
authors.initials: L
authors.lastname: Nathanson
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Farmer
authors.forename: Karyn
authors.initials: K
authors.lastname: Meshbane
authors.forename: Richard L
authors.initials: RL
authors.lastname: Belton
authors.forename: Amy
authors.initials: A
authors.lastname: Dressen
authors.forename: Michael
authors.initials: M
authors.lastname: Cuccaro
authors.forename: Anthony
authors.initials: A
authors.lastname: Musto
authors.forename: Sylvia
authors.initials: S
authors.lastname: Daunert
authors.forename: Sapna
authors.initials: S
authors.lastname: Deo
authors.forename: Natasha
authors.initials: N
authors.lastname: Hudson
authors.forename: Jeffery M
authors.initials: JM
authors.lastname: Vance
authors.forename: David
authors.initials: D
authors.lastname: Seo
authors.forename: Armando
authors.initials: A
authors.lastname: Mendez
authors.forename: Derek M
authors.initials: DM
authors.lastname: Dykxhoorn
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.forename: Pascal J
authors.initials: PJ
authors.lastname: Goldschmidt-Clermont
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D015444:Exercise; D005081:Exercise Therapy; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D005819:Genetic Markers; D016678:Genome; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D010101:Oxygen Consumption; D010809:Physical Fitness; D057185:Sedentary Behavior; D055815:Young Adult
chemical_list: D005819:Genetic Markers