title: Wound healing activity of aqueous extracts of leaves and roots of Coleus aromaticus in rats.
abstract: Present study was aimed to evaluate the wound healing activity of aqueous extract of leaves and roots of Coleus aromaticus using excisional wound model in albino rats. The aqueous extracts were prepared using maceration method and were applied as 5% and 10% ointment. The wound healing activity of these extracts was compared with a standard drug povidone-iodine ointment. The healing tissue was also tested for tensile strength, hydroxyproline content and protein content. The histopathological examination of healing tissue was also performed. Ten percent ointment of aqueous extract of root showed complete epithelization after 12 days (p <0.01) and 5% ointment of leaf extract showed complete healing after 16 days (p <0.01).
authors.affiliation: Department of Pharmacology, G.R. Medical College, Gwalior, India. drakjgrmc@yahoo.com
authors.forename: Anand K
authors.initials: AK
authors.lastname: Jain
authors.forename: Ashish
authors.initials: A
authors.lastname: Dixit
authors.forename: Swaroop C
authors.initials: SC
authors.lastname: Mehta
mesh_terms: D000818:Animals; D031330:Coleus; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts