title: High rates of undiagnosed leprosy and subclinical infection amongst school children in the Amazon Region.
abstract: Leprosy in children is correlated with community-level factors, including the recent presence of disease and active foci of transmission in the community. We performed clinical and serological examinations of 1,592 randomly selected school children (SC) in a cross-sectional study of eight hyperendemic municipalities in the Brazilian Amazon Region. Sixty-three (4%) SC, with a mean age of 13.3 years (standard deviation = 2.6), were diagnosed with leprosy and 777 (48.8%) were seropositive for anti-phenolic glycolipid-I (PGL-I). Additionally, we evaluated 256 house-hold contacts (HHCs) of the students diagnosed with leprosy; 24 (9.4%) HHC were also diagnosed with leprosy and 107 (41.8%) were seropositive. The seroprevalence of anti-PGL-I was significantly higher amongst girls, students from urban areas and students from public schools (p < 0.0001). Forty-five (71.4%) new cases detected amongst SC were classified as paucibacillary and 59 (93.6%) patients did not demonstrate any degree of physical disability at diagnosis. The results of this study suggest that there is a high rate of undiagnosed leprosy and subclinical infection amongst children in the Amazon Region. The advantages of school surveys in hyperendemic areas include identifying leprosy patients at an early stage when they show no physical disabilities, preventing the spread of the infection in the community and breaking the chain of transmission.
authors.affiliation: Laboratório de Dermato-Imunologia, Universidade Federal do Pará, Marituba, PA, Brasil.
authors.forename: Josafá Gonçalves
authors.initials: JG
authors.lastname: Barreto
authors.forename: Layana de Souza
authors.initials: Lde S
authors.lastname: Guimarães
authors.forename: Marco Andrey Cipriani
authors.initials: MA
authors.lastname: Frade
authors.forename: Patricia Sammarco
authors.initials: PS
authors.lastname: Rosa
authors.forename: Claudio Guedes
authors.initials: CG
authors.lastname: Salgado
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000276:immunology; D000942:Antigens, Bacterial / Q000097:blood; D058345:Asymptomatic Infections / Q000453:epidemiology; D001938:Brazil / Q000453:epidemiology; D002648:Child; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006017:Glycolipids / Q000097:blood; D006801:Humans; D056006:Leprosy, Multibacillary / Q000175:diagnosis* / Q000453:epidemiology; D056005:Leprosy, Paucibacillary / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D009166:Mycobacterium leprae / Q000276:immunology; D016036:Seroepidemiologic Studies; D013334:Students
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D006017:Glycolipids; C045169:phenolic glycolipid I, Mycobacterium leprae