title: Burdock fermented by Aspergillus awamori elevates cecal Bifidobacterium, and reduces fecal deoxycholic acid and adipose tissue weight in rats fed a high-fat diet.
abstract: This study investigated the effects of dietary supplementation with burdock powder and Aspergillus awamori-fermented burdock powder at 5% on the intestinal luminal environment and body fat in rats fed a high-fat (HF) diet. Food intake and growth were unaffected by dietary manipulation. Consumption of the burdock and fermented burdock diets significantly elevated fecal IgA and mucins (indices of intestinal immune and barrier functions) and reduced fecal lithocholic acid (a risk factor for colon cancer) (p<0.05). The fermented burdock diet markedly elevated cecal Bifidobacterium and organic acids, including lactate, acetate, propionate, and butyrate, and reduced fecal deoxycholic acid (a risk factor for colon cancer) and perirenal adipose tissue weight (p<0.05), but the burdock diet did not. These results suggest that consumption of fermented burdock improves the intestinal luminal environment and suppresses obesity in rats fed a HF diet.
authors.affiliation: Faculty of Human Life Sciences, Fuji Women's University, Ishikari, Japan. yokazaki@fujijoshi.ac.jp
authors.forename: Yukako
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Novita Vivi
authors.initials: NV
authors.lastname: Sitanggang
authors.forename: Satoko
authors.initials: S
authors.lastname: Sato
authors.forename: Nanae
authors.initials: N
authors.lastname: Ohnishi
authors.forename: Junji
authors.initials: J
authors.lastname: Inoue
authors.forename: Takafumi
authors.initials: T
authors.lastname: Iguchi
authors.forename: Toshiro
authors.initials: T
authors.lastname: Watanabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tomotake
authors.forename: Kazuki
authors.initials: K
authors.lastname: Harada
authors.forename: Norihisa
authors.initials: N
authors.lastname: Kato
mesh_terms: D019342:Acetic Acid / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D031170:Arctium / Q000737:chemistry*; D001230:Aspergillus / Q000378:metabolism*; D001644:Bifidobacterium / Q000254:growth & development / Q000378:metabolism; D020148:Butyric Acid / Q000378:metabolism; D002432:Cecum / Q000737:chemistry* / Q000382:microbiology; D003840:Deoxycholic Acid / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D019587:Dietary Supplements; D004435:Eating / Q000187:drug effects; D005243:Feces / Q000737:chemistry; D005285:Fermentation; D007070:Immunoglobulin A / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D009077:Mucins / Q000378:metabolism; D009765:Obesity / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D011208:Powders / Q000008:administration & dosage*; D011422:Propionates / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007070:Immunoglobulin A; D009077:Mucins; D011208:Powders; D011422:Propionates; D003840:Deoxycholic Acid; D020148:Butyric Acid; D019344:Lactic Acid; C029658:propionic acid; D019342:Acetic Acid