title: Body size phenotypes and low muscle mass: the Korean sarcopenic obesity study (KSOS).
abstract: BACKGROUND
  Unique subsets of body size phenotypes seem to be more prone or more resistant to the development of obesity-associated metabolic disorders, although the underlying mechanism is not yet clearly understood.
  
  
  OBJECTIVE
  We investigated the prevalence and risk of low muscle mass in subjects who are classified as either metabolically healthy normal weight (MHNW), metabolically abnormal but normal weight (MANW), metabolically healthy obese (MHO), or metabolically abnormal obese (MAO). Subjects were classified based on body mass index and presence of metabolic syndrome.
  
  
  METHODS
  Thigh muscle cross-sectional area was evaluated using computed tomography as an index of muscle mass in 492 apparently healthy adults enrolled in the Korean Sarcopenic Obesity Study (KSOS), an ongoing prospective observational cohort study. Low muscle mass was defined as thigh muscle cross-sectional area divided by weight (percent) of <1 SD below the mean values of young adults in both sexes.
  
  
  RESULTS
  The prevalence rates of low muscle mass in MHNW, MANW, MHO, and MAO subjects were 6.2%, 17.8%, 23.2%, and 33.7%, respectively. In a multiple logistic regression analysis, men with the MANW phenotype showed a remarkably increased risk of low muscle mass (odds ratio = 11.30, 95% confidence interval, 1.73-73.28) compared with those with MHNW. Furthermore, in both men and women, MHO or MAO subjects had higher odds ratios of low muscle mass compared with MHNW subjects.
  
  
  CONCLUSIONS
  The present study suggests that low muscle mass may be associated with different metabolic consequences according to body size phenotype.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, 80 Guro-Dong, Guro-Gu, Seoul 152-050, Korea.
authors.forename: Tae Nyun
authors.initials: TN
authors.lastname: Kim
authors.forename: Man Sik
authors.initials: MS
authors.lastname: Park
authors.forename: Sae Jeong
authors.initials: SJ
authors.lastname: Yang
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Yoo
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Kang
authors.forename: Wook
authors.initials: W
authors.lastname: Song
authors.forename: Ji A
authors.initials: JA
authors.lastname: Seo
authors.forename: Sin Gon
authors.initials: SG
authors.lastname: Kim
authors.forename: Nan Hee
authors.initials: NH
authors.lastname: Kim
authors.forename: Sei Hyun
authors.initials: SH
authors.lastname: Baik
authors.forename: Dong Seop
authors.initials: DS
authors.lastname: Choi
authors.forename: Kyung Mook
authors.initials: KM
authors.lastname: Choi
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001823:Body Composition; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism; D010641:Phenotype; D015995:Prevalence; D011446:Prospective Studies; D056910:Republic of Korea; D055948:Sarcopenia / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism