title: Exploiting specific interactions toward next-generation polymeric drug transporters.
abstract: A generic method describes advanced tailoring of polymer drug carriers based on polymer-block-peptides. Combinatorial means are used to select suitable peptide segments to specifically complex small-molecule drugs. The resulting specific drug formulation agents render insoluble drugs water-soluble and enable precise adjustment of drug-release profiles beyond established block-copolymer carriers. While proof of principle is shown on chlorin as a partially approved drug for photodynamic cancer therapy, the concept is universal and applies to a broad spectrum of difficult drugs.
authors.affiliation: Laboratory for Organic Synthesis of Functional Systems, Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, D-12489 Berlin, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wieczorek
authors.forename: Eberhard
authors.initials: E
authors.lastname: Krause
authors.forename: Steffen
authors.initials: S
authors.lastname: Hackbarth
authors.forename: Beate
authors.initials: B
authors.lastname: Röder
authors.forename: Anna K H
authors.initials: AK
authors.lastname: Hirsch
authors.forename: Hans G
authors.initials: HG
authors.lastname: Börner
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D008652:Mesoporphyrins / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D010778:Photochemotherapy; D011108:Polymers / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008652:Mesoporphyrins; D010455:Peptides; D011108:Polymers; C072269:temoporfin