title: Etiologic factors associated with oral squamous cell carcinoma in non-smokers and non-alcoholic drinkers: a brief approach.
abstract: Oral squamous cell carcinoma (OSCC) is the fifth most common type of cancer in the world. The effect of some etiological factors is well established in the literature, such as consumption of tobacco and alcohol. However, approximately 15 to 20% of all oral cancer cases occur in patients without the traditional risk factors, reflecting in numerous cases of OSCC in non-smokers and non-alcoholic drinkers. Also, several studies have suggested a possible association between human papillomavirus and OSCC. Under these aspects, the purpose of this study is to address cases of oral cancer in non-smokers and non-drinkers focusing on the role of HPV, thus contributing to improve the diagnosis and monitoring of OSCC. A computer database search was performed using the Pubmed database. The search key words were: epidemiology, oral squamous cell carcinoma, risk factors and human papillomavirus. It is important to assess patients without the potential risk factors, since this knowledge may help identifying other features associated with the occurrence of oral cancer, enabling an appropriate clinical management and monitoring.
authors.affiliation: Departament of Social Medicine, Federal University of Pelotas, RS, Brazil. fabivfer@yahoo.com.br
authors.forename: Fabiana
authors.initials: F
authors.lastname: Vargas-Ferreira
authors.forename: Fernanda
authors.initials: F
authors.lastname: Nedel
authors.forename: Adriana
authors.initials: A
authors.lastname: Etges
authors.forename: Ana Paula Neutzling
authors.initials: AP
authors.lastname: Gomes
authors.forename: Cristiane
authors.initials: C
authors.lastname: Furuse
authors.forename: Sandra Beatriz Chaves
authors.initials: SB
authors.lastname: Tarquinio
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000209:etiology*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects