title: An IL-6 link between obesity and cancer.
abstract: Obesity is a growing epidemic all over the world that by virtue of inducation of a chronic, low-grade, and systemic inflammation leads to an increased risk of a number of diseases, including cancer. IL-6 an important cytokine in the increased risk to cancer in obese patients mainly because of its pro-inflammatory activity. Some data suggest that IL-6 might increase the risk of certain cancers such as those that originate from breast, liver, prostate, colon, and esophagus. A better understanding of the regulation and role of IL-6 in obesity-associated cancer is required to develop effective therapeutic approaches.
authors.affiliation: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Dr, San Antonio, TX-78245, USA. ghoshs3@uthscsa.edu
authors.forename: Sagar
authors.initials: S
authors.lastname: Ghosh
authors.forename: Keith
authors.initials: K
authors.lastname: Ashcraft
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000378:metabolism
chemical_list: D015850:Interleukin-6