title: Signals regulating L-selectin-dependent leucocyte adhesion and transmigration.
abstract: L-selectin is a type I transmembrane cell adhesion molecule that is expressed on the surface of most circulating leukocytes. Studies in L-selectin knockout mice reveal a prominent role for this glycoprotein in health and disease, regulating leucocyte recruitment to peripheral lymph nodes (e.g. naïve T-cells) and sites of acute and chronic inflammation (e.g. monocytes and neutrophils). Clinical trials have revealed L-selectin as a promising target in some acute and chronic inflammatory diseases. Unearthing the intracellular signals that act directly downstream of L-selectin may also expose novel therapeutic targets in a cell type/disease-specific manner. This review will focus on L-selectin-dependent signalling - exploring the different signals that potentially arise from distinct phases of the multi-step adhesion cascade and the contribution of known binding partners of L-selectin in this response.
authors.affiliation: Membrane/Cytoskeleton Signalling Group, Cardiovascular Division, British Heart Foundation, Centre of Research Excellence, King's College London, London SE5 9NU, United Kingdom. aleksandar.ivetic@kcl.ac.uk
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Ivetic
mesh_terms: D000818:Animals; D002147:Calmodulin / Q000235:genetics / Q000378:metabolism*; D002448:Cell Adhesion / Q000235:genetics*; D002465:Cell Movement / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D019041:L-Selectin / Q000235:genetics / Q000378:metabolism*; D007962:Leukocytes / Q000166:cytology / Q000378:metabolism; D051379:Mice; D011493:Protein Kinase C / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D002147:Calmodulin; D019041:L-Selectin; D011493:Protein Kinase C