title: Two cases of Mycoplasma pneumoniae pneumonia with A2063G mutation in the 23S rRNA gene in siblings.
abstract: We describe 2 cases of pneumonia caused by the same macrolide-resistant Mycoplasma pneumoniae in siblings. M. pneumoniae was identified using real-time PCR. Direct sequence analysis of the 23S rRNA gene revealed a point mutation in V domain (A2063G) of the 23S rRNA gene.
authors.affiliation: Department of Pediatrics, Wonju Medical Center, Wonju, Korea.
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Hong
authors.forename: Jin Kyong
authors.initials: JK
authors.lastname: Chun
authors.forename: Young
authors.initials: Y
authors.lastname: Uh
authors.forename: Ki Jin
authors.initials: KJ
authors.lastname: Oh
authors.forename: Juwon
authors.initials: J
authors.lastname: Kim
authors.forename: Kap Jun
authors.initials: KJ
authors.lastname: Yoon
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006801:Humans; D018942:Macrolides / Q000494:pharmacology; D008297:Male; D009154:Mutation; D009177:Mycoplasma pneumoniae / Q000235:genetics* / Q000302:isolation & purification; D011019:Pneumonia, Mycoplasma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000382:microbiology; D012338:RNA, Ribosomal, 23S / Q000032:analysis*; D011859:Radiography; D060888:Real-Time Polymerase Chain Reaction; D017423:Sequence Analysis, RNA; D035781:Siblings
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D012338:RNA, Ribosomal, 23S
keywords: 23S rRNA; Macrolide; Mycoplasma pneumoniae; Pneumonia