title: [Effects of smoking on the concentrations of urinary 10 metabolites of polycyclic aromatic hydrocarbons in coke oven workers].
abstract: OBJECTIVE
  To explore the effects of smoking on urinary 10 metabolites of polycyclic aromatic hydrocarbons (PAHs) in the coke oven workers.
  
  
  METHODS
  Occupational health examination was performed on 1401 coke oven workers in one coking plant, their urine were collected respectively. The concentrations of the ten monohydroxy polycyclic aromatic hydrocarbons in urine were detected by gas chromatography/mass spectrometry. The 1401 workers were divided into four groups, namely control, adjunct workplaces, bottom and side, top group according to their workplaces and the different concentrations of PAHs in the environment. The concentrations of the ten monohydroxy polycyclic aromatic hydrocarbons between smokers and nonsmokers in each workplace group were compared using analysis of covariance, respectively.
  
  
  RESULTS
  The levels of concentrations of the sixteen polycyclic aromatic hydrocarbons we detected at control were significantly higher than those at other areas (P < 0.05). Comparing the ten monohydroxy polycyclic aromatic hydrocarbons levels between smokers and nonsmokers, the levels of 1-hydroxynaphthalene and 2-hydroxynaphthalene among smokers were higher than nonsmokers with statistically significance in control, adjunct workplaces, bottom and side and top groups (P < 0.05). However, the levels of 1-hydroxypyrene had no statistically significant differences between the four areas.
  
  
  CONCLUSIONS
  Urinary 1-hydroxynaphthalene and 2-hydroxynaphthalene may be used as biomarkers for the impact of smoking on monohydroxy polycyclic aromatic hydrocarbons in the coke oven workers.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Yun-feng
authors.initials: YF
authors.lastname: He
authors.forename: Wang-zhen
authors.initials: WZ
authors.lastname: Zhang
authors.forename: Dan
authors.initials: D
authors.lastname: Kuang
authors.forename: Hua-xin
authors.initials: HX
authors.lastname: Deng
authors.forename: Xiao-hai
authors.initials: XH
authors.lastname: Li
authors.forename: Da-feng
authors.initials: DF
authors.lastname: Lin
authors.forename: Qi-fei
authors.initials: QF
authors.lastname: Deng
authors.forename: Kun
authors.initials: K
authors.lastname: Huang
authors.forename: Tang-chun
authors.initials: TC
authors.lastname: Wu
mesh_terms: D000395:Air Pollutants, Occupational / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D003077:Coke; D006801:Humans; D008297:Male; D009284:Naphthols / Q000652:urine; D016273:Occupational Exposure / Q000032:analysis*; D011084:Polycyclic Aromatic Hydrocarbons / Q000652:urine*; D011721:Pyrenes / Q000652:urine; D012907:Smoking / Q000652:urine*
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D003077:Coke; D009284:Naphthols; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; C029350:1-naphthol; C033146:1-hydroxypyrene; C028405:2-naphthol