title: Fabrication and characterization of plasma-polymerized poly(ethylene glycol) film with superior biocompatibility.
abstract: A newly fabricated plasma-polymerized poly(ethylene glycol) (PP-PEG) film shows extremely low toxicity, low fouling, good durability, and chemical similarity to typical PEG polymers, enabling live cell patterning as well as various bioapplications using bioincompatible materials. The PP-PEG film can be overlaid on any materials via the capacitively coupled plasma chemical vapor deposition (CCP-CVD) method using nontoxic PEG200 as a precursor. The biocompatibility of the PP-PEG-coated surface is confirmed by whole blood flow experiments where no thrombi and less serum protein adsorption are observed when compared with bare glass, polyethylene (PE), and polyethylene terephthalate (PET) surfaces. Furthermore, unlike bare PE films, less fibrosis and inflammation are observed when the PP-PEG-coated PE film is implanted into subcutaneous pockets of mice groin areas. The cell-repellent property of PP-PEG is also verified via patterning of mammalian cells, such as fibroblasts and hippocampal neurons. These results show that our PP-PEG film, generated by the CCP-CVD method, is a biocompatible material that can be considered for broad applications in biomedical and functional materials fields.
authors.affiliation: Center for Nano-Bio Convergence, World Class Laboratory, Korea Research Institute of Standards and Science, Daejeon, 305-340, Korea.
authors.forename: Changrok
authors.initials: C
authors.lastname: Choi
authors.forename: Inseong
authors.initials: I
authors.lastname: Hwang
authors.forename: Young-Lai
authors.initials: YL
authors.lastname: Cho
authors.forename: Sang Y
authors.initials: SY
authors.lastname: Han
authors.forename: Dong H
authors.initials: DH
authors.lastname: Jo
authors.forename: Donggeun
authors.initials: D
authors.lastname: Jung
authors.forename: Dae W
authors.initials: DW
authors.lastname: Moon
authors.forename: Eun J
authors.initials: EJ
authors.lastname: Kim
authors.forename: Chang S
authors.initials: CS
authors.lastname: Jeon
authors.forename: Jeong H
authors.initials: JH
authors.lastname: Kim
authors.forename: Taek D
authors.initials: TD
authors.lastname: Chung
authors.forename: Tae G
authors.initials: TG
authors.lastname: Lee
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000166:cytology; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D051379:Mice; D008810:Mice, Inbred C57BL; D011092:Polyethylene Glycols / Q000737:chemistry*; D058105:Polymerization; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D011092:Polyethylene Glycols