title: Mixed neuroendocrine tumor of the common bile duct.
abstract: BACKGROUND
  Mixed adenoendocrine tumors of the extrahepatic bile ducts are exceedingly rare and most of those who are rarely diagnosed are adenocarcinomas. Neuroendorine tumors accounts for only 0.2-2%.
  
  
  METHODS
  We report a case of mixed adenoneuroendo-carcinoma of the common bile duct in an 82-year-old male.
  
  
  CONCLUSIONS
  Clinical experience suggests that the neuroendocrine component of mixed tumors behave more aggressively than the regular biliary adenocarcinoma component. This clinical behavior may have an important role in the management of this clinical entity.
authors.affiliation: Division of Surgical Oncology, Department of General Surgery, Rambam Health Care Center, Haifa, Israel.
authors.forename: Revital
authors.initials: R
authors.lastname: Linder
authors.forename: Tatiana
authors.initials: T
authors.lastname: Dorfman
authors.forename: Offir
authors.initials: O
authors.lastname: Ben-Ishay
authors.forename: Eli
authors.initials: E
authors.lastname: Kakiashvili
authors.forename: Eugene
authors.initials: E
authors.lastname: Velodavsky
authors.forename: Yoram
authors.initials: Y
authors.lastname: Kluger
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery; D000369:Aged, 80 and over; D053379:Chromogranin A / Q000032:analysis; D003135:Common Bile Duct / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018198:Mixed Tumor, Malignant / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D016708:Synaptophysin / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D053379:Chromogranin A; D016708:Synaptophysin