title: The miRNAs in the pathgenesis of osteosarcoma.
abstract: Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. MicroRNAs (miRNAs) are non-coding small RNAs, usually 18-25 nucleotides in length, which repress translation and cleave mRNA by base-pairing to the 3 untranslated region of the target genes. miRNAs have demonstrated far-reaching effects on the cellular biology of development and cancer. Their role in osteosarcomagenesis remains largely unexplored. A number of reports have investigated the role of microRNAs in osteosarcoma. This review summeizes the recent research progress of miRNA in the osteosarcome.
authors.affiliation: Department of Orthopedics, Changhai Hospital of Second Military Medical University, Shanghai 200433, China.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Liang
authors.forename: Bo
authors.initials: B
authors.lastname: Gao
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.forename: Shuogui
authors.initials: S
authors.lastname: Xu
authors.forename: Yu
authors.initials: Y
authors.lastname: Qian
authors.forename: Qingge
authors.initials: Q
authors.lastname: Fu
mesh_terms: D001859:Bone Neoplasms / Q000235:genetics*; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000627:therapeutic use; D009361:Neoplasm Invasiveness / Q000235:genetics; D009857:Oncogenes / Q000502:physiology; D012516:Osteosarcoma / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors
chemical_list: D035683:MicroRNAs; C544302:Mirn140 microRNA, human; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53