title: [Investigation on the source of infection regarding an avian influenza (H5N1) case in Hong Kong that returning from Guangzhou].
abstract: OBJECTIVE
  We conducted an epidemiologic investigation to determine the source of infection on an avian influenza (H5N1) case who returned from Guangzhou, in Hong Kong.
  
  
  METHODS
  Data related to epidemiologic investigation, medical observation on close contacts, Syndromic Surveillance on poultry salesmen, emergency monitoring, detection of the samples, source tracing on potential Avian influenza virus (H5, H7, H9) infected people, situation on environment pollution by avian influenza virus in the markets etc. were gathered. The determination of infection source was through comparing the different genes between the case and positive environmental samples.
  
  
  RESULTS
  The infected case witnessed the procedure of how a live duck was killed, in market A in Guangzhou during May 17(th) to 19(th). The case was diagnosed as respiratory tract infection in 2 Third-grade-Class A hospitals in Guangzhou on May 23(th) and 24(th). The diagnosis was made as Avian influenza cases on May 26(th) after going back to Hong Kong. 23 close contacts and 34 markets poultry salesmen did not show any ILI related symptoms. However, 2 poultry salesmen from the markets nearby the place where the Avian influenza case stayed, were detected having positive H9 avian influenza antibody, with the H9 positive rate as 6.06% (2/33). Among the environmental samples in the 2 markets nearby home of the patient, chopping block was found to have carried H5, with positive rate as 9.8% (5/51) while poultry cage was found to carry H9, with the positive rate as 2.0% (1/51). A H5 positive sample was found with clade 2.3.2.1, same to the case, from a chopping block at the market B where the sources of poultry was the same as market A.
  
  
  CONCLUSIONS
  The source of infection seemed to come from the markets in Guangzhou, that calling for the strengthening of poultry market management, for avian influenza prevention. History related to contact of poultry should be gathered when a diagnosis of respiratory tract infection was made. Timely sampling and testing should be made to improve the sensitivity of diagnosis.
authors.affiliation: Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yuan
authors.forename: Yu-fei
authors.initials: YF
authors.lastname: Liu
authors.forename: Kui-biao
authors.initials: KB
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Chao-jun
authors.initials: CJ
authors.lastname: Xie
authors.forename: Wen-feng
authors.initials: WF
authors.lastname: Cai
authors.forename: Jie-yun
authors.initials: JY
authors.lastname: Pan
authors.forename: Qing-lian
authors.initials: QL
authors.lastname: Liu
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Xiao
authors.forename: Biao
authors.initials: B
authors.lastname: DI
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Liu
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Ma
authors.forename: Yan-hui
authors.initials: YH
authors.lastname: Liu
authors.forename: Zhi-cong
authors.initials: ZC
authors.lastname: Yang
mesh_terms: D000818:Animals; D002675:Child, Preschool; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype; D005585:Influenza in Birds / Q000453:epidemiology; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology*; D008297:Male; D011200:Poultry / Q000821:virology