title: [Investigation and analysis of chloride channels distribution over the surface and T-tubule membranes of frog skeletal muscle].
abstract: Two types of muscle fibre integral currents (T1T and T2T) were recorded using narrow-tipped extracellular pipettes in isolated sartorius muscles of frog, Rana temporaria. T1T and T2T responses presumably were generated by currents originating in the muscle fibers sarcolemma (M-band region) or both sarcolemma and T-system (Z-line region), respectively, and differently responded to the selective blockade of C1C chloride channels with anthracene-9-carboxylic acid (9-AC). Eva- luation of the role of prolongation of T1T responses in generation of multiple peaks of the second phase (Na current) of T2T integral currents in muscle fibers are discussed.
authors.forename: I V
authors.initials: IV
authors.lastname: Kubasov
authors.forename: R S
authors.initials: RS
authors.lastname: Arutiunian
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000873:Anthracenes / Q000494:pharmacology; D018118:Chloride Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003470:Culture Media; D004558:Electric Stimulation; D004566:Electrodes; D009119:Muscle Contraction / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D009924:Organ Culture Techniques; D011896:Rana temporaria; D012508:Sarcolemma / Q000187:drug effects / Q000502:physiology*
chemical_list: D000873:Anthracenes; D018118:Chloride Channels; D003470:Culture Media; C010030:9-anthroic acid