title: New insights in research about acute ischemic myocardial injury and inflammation.
abstract: Recognition that inflammation may contribute to the pathogenesis of various cardiac diseases has naturally led to the evaluation of the therapeutic potential of a range of anti-inflammatory approaches. Unfortunately, results in most settings have been disappointing. The majority of novel approaches fail despite promising preclinical data, partly attributable to off-target effects. The purpose of this review, focused on inflammation following acute myocardial ischemia, is to give a brief overview of the new insights regarding research on pro-inflammatory signaling cascades that could be targeted for cardioprotective therapeutic developments.
authors.affiliation: CNRS, UMR-5203, Institut de Génomique Fonctionnelle, 141, rue de Cardonille - 34094 Montpellier Cedex 5 - France. anne.vincent@igf.cnrs.fr
authors.forename: Anne
authors.initials: A
authors.lastname: Vincent
authors.forename: Benoit
authors.initials: B
authors.lastname: Lattuca
authors.forename: Nolwenn
authors.initials: N
authors.lastname: Merlet
authors.forename: Catherine
authors.initials: C
authors.lastname: Sportouch-Dukhan
authors.forename: Stephanie
authors.initials: S
authors.lastname: Barrère-Lemaire
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines