title: Comparison of coronary plaque subtypes in male and female patients using 320-row MDCTA.
abstract: OBJECTIVE
  Determine plaque subtype and volume difference in male and female patients with obstructive and non-obstructive CAD using 320-row MDCTA.
  
  
  METHODS
  128 patients with suspected CAD underwent MDCTA. All studies were divided into two groups based on disease severity. 0-70% stenosis (non-obstructive CAD) & >70% (obstructive). All were compared for plaque quantity and subtypes by gender. Main arteries, RCA, LM, LAD and LCX were analyzed using Vitrea 5.2 software to quantify fatty, fibrous and calcified plaque. Thresholds for coronary plaque quantification (volume in mm(3)) were preset at 35 ± 12 HU for fatty, 90 ± 24 HU for fibrous and >130 HU for calcified/mixed plaque and analyzed using STATA software.
  
  
  RESULTS
  Total plaque burden in 118 patients [65M: 53F] was significantly higher in all arteries in males compared to females with non-obstructive disease. Total plaque volume for males vs. females was: RCA: 10.10 ± 5.02 mm(3) vs. 6.89 ± 2.75 mm(3), respectively, p = 0.001; LAD: 7.21 ± 3.38 mm(3) vs. 5.89 ± 1.93 mm(3), respectively, p = 0.04; LCX: 9.13 ± 3.27 mm(3) vs. 7.16 ± 1.73 mm(3), respectively, p = 0.002; LM 15.13 ± 4.51 mm(3) vs. 11.85 ± 4.03 mm(3), respectively, p = 0.001. In sub-analyses, males had significantly more fibrous and fatty plaque in LM, LAD & LCX than females. However in the RCA, only fibrous plaque was significantly greater in males. Calcified plaque volume was not significantly different in both genders. Only 8% of patients had obstructive CAD (>70% stenosis); there was no significant difference in plaque volume or subtypes.
  
  
  CONCLUSIONS
  In patients with non-obstructive CAD, males were found to have significantly higher total coronary plaque volume with predominance of fibrous and fatty subtypes compared to females of the same age and BMI. There was no significant difference in plaque subtype or volume in patients with obstructive disease.
authors.affiliation: Emory University Hospital, Midtown, GA, USA; Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room L347, Boston, MA 02215, USA. fkhosa@bidmc.harvard.edu
authors.forename: Faisal
authors.initials: F
authors.lastname: Khosa
authors.forename: Atif N
authors.initials: AN
authors.lastname: Khan
authors.forename: Khurram
authors.initials: K
authors.lastname: Nasir
authors.forename: Arash
authors.initials: A
authors.lastname: Bedayat
authors.forename: Zehra
authors.initials: Z
authors.lastname: Malik
authors.forename: Ali F
authors.initials: AF
authors.lastname: Jon
authors.forename: Ahmad R
authors.initials: AR
authors.lastname: Cheema
authors.forename: Melvin E
authors.initials: ME
authors.lastname: Clouse
authors.forename: Francine K
authors.initials: FK
authors.lastname: Welty
mesh_terms: D000368:Aged; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000473:pathology; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging / Q000473:pathology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods