title: Integrated optical- and acoustic-resolution photoacoustic microscopy based on an optical fiber bundle.
abstract: Photoacoustic microscopy (PAM), whose spatial resolution and maximum imaging depth are both scalable, has made great progress in recent years. However, each PAM system currently achieves only one resolution with an associated maximum imaging depth. Here, we present an integrated optical-resolution (OR) and acoustic-resolution (AR) PAM system implemented by delivering light via an optical fiber bundle. A single fiber core is used to deliver light for OR illumination in order to achieve a small spot size and hence high lateral resolution, whereas all the fiber cores are used to deliver more energy for AR illumination. Most other components are shared by the OR and AR imaging. The lateral resolution can be seamlessly switched between 2.2 and 40 μm as the maximum imaging depth is switched between 1.3 and 3.0 mm. The system enables automatically coregistered higher-resolution OR and deeper AR photoacoustic imaging.
authors.affiliation: Optical Imaging Laboratory, Department of Biomedical Engineering.|Preston M. Green Department of Electrical and Systems Engineering, Washington University in St. Louis, One Brookings Drive, St. Louis, Missouri 63130, USA.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Xing
authors.affiliation: Optical Imaging Laboratory, Department of Biomedical Engineering.
authors.forename: Lidai
authors.initials: L
authors.lastname: Wang
authors.affiliation: Optical Imaging Laboratory, Department of Biomedical Engineering.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Maslov
authors.affiliation: Optical Imaging Laboratory, Department of Biomedical Engineering.|Preston M. Green Department of Electrical and Systems Engineering, Washington University in St. Louis, One Brookings Drive, St. Louis, Missouri 63130, USA.
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
mesh_terms: D054459:Elasticity Imaging Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D007089:Image Enhancement / Q000295:instrumentation*; D008029:Lighting / Q000295:instrumentation*; D061088:Photoacoustic Techniques / Q000295:instrumentation*; D013382:Subtraction Technique / Q000295:instrumentation*; D018511:Systems Integration