title: Electrochemical study of the anticancer drug daunorubicin at a water/oil interface: drug lipophilicity and quantification.
abstract: In this work, the ion transfer mechanism of the anticancer drug daunorubicin (DNR) at a liquid/liquid interface has been studied for the first time. This study was carried out using electrochemical techniques, namely cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The lipophilicity of DNR was investigated at the water/1,6-dichlorohexane (DCH) interface, and the results obtained were presented in the form of an ionic partition diagram. The partition coefficients of both neutral and ionic forms of the drug were determined. The analytical parameter for the detection of DNR was also investigated in this work. An electrochemical DNR sensor is proposed by means of simple ion transfer at the water/DCH interface, using DPV as the quantification technique. Experimental conditions for the analytical determination of DNR were established, and a detection limit of 0.80 μM was obtained.
authors.affiliation: Faculdade de Ciências da Universidade do Porto, Departamento de Química e Bioquímica, Centro de Investigação em Química, Linha 4, Rua do Campo Alegre 687, 4169-007 Porto, Portugal.
authors.forename: José A
authors.initials: JA
authors.lastname: Ribeiro
authors.forename: F
authors.initials: F
authors.lastname: Silva
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Pereira
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000378:metabolism; D003630:Daunorubicin / Q000737:chemistry* / Q000378:metabolism; D055664:Electrochemical Techniques / Q000379:methods*; D006801:Humans; D009821:Oils / Q000737:chemistry* / Q000378:metabolism; D014867:Water / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000903:Antibiotics, Antineoplastic; D009821:Oils; D014867:Water; D003630:Daunorubicin