title: Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates.
abstract: The size of a nanomedicine strongly correlates with its biodistribution, tissue penetration, and cell uptake. However, there is limited understanding how the size of nanomedicine impacts the overall antitumor efficacy. We designed and synthesized camptothecin-silica nanoconjugates (Cpt-NCs) with monodisperse particle sizes of 50 and 200 nm, two representative sizes commonly used in drug delivery, and evaluated their antitumor efficacy in murine tumor models. Our studies revealed that the 50 nm Cpt-NC showed higher anticancer efficacy than the larger analogue, due presumably to its faster cellular internalization and more efficient tumor accumulation and penetration. Our findings suggest that nanomedicine with smaller sizes holds great promise for improved cancer therapy.
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, Illinois 61801, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Tang
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Gabrielson
authors.forename: Fatih M
authors.initials: FM
authors.lastname: Uckun
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Fan
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000818:Animals; D002166:Camptothecin / Q000737:chemistry*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D006367:HeLa Cells; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D018613:Microscopy, Confocal; D058726:Nanoconjugates / Q000008:administration & dosage / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D058726:Nanoconjugates; D012822:Silicon Dioxide; D002166:Camptothecin