title: Case-control study of cutaneous human papillomavirus infection in Basal cell carcinoma of the skin.
abstract: Genus-β human papillomavirus (HPV) DNA has been detected in basal cell carcinoma (BCC) tumors, but most epidemiologic studies have not observed associations between genus-β HPV seropositivity and BCC. A clinic-based case-control study was conducted to investigate cutaneous HPV infection in BCC. BCC cases (n=224) were recruited from a dermatology clinic, and controls (n=300) were patients who were screened negative for skin cancer. Antibodies against cutaneous HPV types in genera α, β, γ, mu, and nu were measured, and tumors from a subset of BCC cases (n=195) were tested for HPV DNA. Overall associations were observed between BCC and seropositivity for HPV types in genus-α (odds ratio (OR)=1.61; 95% confidence interval (CI)=1.11-2.35), γ (OR=1.78; 95% CI=1.22-2.60), and mu (OR=1.56; 95% CI=1.06-2.30). BCC cases with β-HPV DNA in their tumors were more likely to be β-HPV seropositive than controls (OR=1.76; 95% CI=1.03-3.01), with type-specific associations observed for HPV8 and HPV23, whereas no association was observed between β-HPV seropositivity and β-HPV DNA-negative BCC. No concordance between seropositivity and tumor DNA status was observed for HPV types in genera α and γ. In conclusion, the combined serology and tumor DNA results suggest that β HPV types may have a role in BCC. Additional studies of BCC that assess HPV types in multiple genera are needed.
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33647, USA.
authors.forename: Michelle R
authors.initials: MR
authors.lastname: Iannacone
authors.forename: Tarik
authors.initials: T
authors.lastname: Gheit
authors.forename: Tim
authors.initials: T
authors.lastname: Waterboer
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
authors.forename: Jane L
authors.initials: JL
authors.lastname: Messina
authors.forename: Neil A
authors.initials: NA
authors.lastname: Fenske
authors.forename: Basil S
authors.initials: BS
authors.lastname: Cherpelis
authors.forename: Vernon K
authors.initials: VK
authors.lastname: Sondak
authors.forename: Richard G
authors.initials: RG
authors.lastname: Roetzheim
authors.forename: Sandra
authors.initials: S
authors.lastname: Ferrer-Gil
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Michael
authors.forename: Sandrine
authors.initials: S
authors.lastname: McKay-Chopin
authors.forename: Michael
authors.initials: M
authors.lastname: Pawlita
authors.forename: Massimo
authors.initials: M
authors.lastname: Tommasino
authors.forename: Dana E
authors.initials: DE
authors.lastname: Rollison
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D052685:Alphapapillomavirus / Q000235:genetics / Q000302:isolation & purification*; D052686:Betapapillomavirus / Q000235:genetics / Q000302:isolation & purification*; D002280:Basal Cell Carcinoma / Q000453:epidemiology / Q000821:virology*; D016022:Case-Control Studies; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D052689:Gammapapillomavirus / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D052692:Mupapillomavirus / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D016036:Seroepidemiologic Studies; D012878:Skin Neoplasms / Q000453:epidemiology / Q000821:virology*; D055815:Young Adult
chemical_list: D004279:DNA, Viral