title: [Molecular basis of Waldenström macroglobulinemia].
abstract: Waldenström macroglobulinemia is a rare lymphoproliferative disease that is currently classified into lymphomas with incidence of 3 cases per million. This disease comprises about 1-2% of hematological malignancies and is characterized by infiltration of malignant B cells into the bone marrow and presence of monoclonal immunoglobulin IgM in serum. WM is still an incurable disease with median survival of 5 years. Molecular basis of this disease remains unclear even though deletion of 6q, trisomy of chromosomes 4 and 8, deletion of 13q and increased expression of IL-6 seem to be typical for this disease. The most important changes of microRNA are increased expression of miR-155 and decreased expression of miR-9*. This work aims to describe current knowledge about the molecular basis of this disease.
authors.affiliation: Babakova myelomova skupina, Ustav patologicke fyziologie, Kamenice, Brno. sevcik@med.muni.cz
authors.forename: S
authors.initials: S
authors.lastname: Sevčíková
authors.forename: L
authors.initials: L
authors.lastname: Novák
authors.forename: L
authors.initials: L
authors.lastname: Kubiczková
authors.forename: E
authors.initials: E
authors.lastname: Dementyeva
authors.forename: L
authors.initials: L
authors.lastname: Ríhová
authors.forename: R
authors.initials: R
authors.lastname: Hájek
mesh_terms: D002869:Chromosome Aberrations; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics* / Q000378:metabolism*
chemical_list: D035683:MicroRNAs