title: Progressive fiber tract affections after temporal lobe surgery.
abstract: Several studies reported changes in white matter architecture following temporal lobe surgery in patients with temporal lobe epilepsy (TLE) at short intervals after surgery. We investigated 20 patients with left-sided TLE using diffusion-imaging at two time points, that is, at 3-6 months and 12 months after surgery, to investigate postsurgical plasticity. We observed a loss of fiber tract integrity mainly in fiber tracts of the ipsilateral temporal lobe. Our data show that the remodeling of brain connectivity after surgical interventions continues for longer time periods. The functional implications of these plastic changes will have to be explored.
authors.affiliation: Department of Epileptology, University of Bonn Medical Center, Bonn, Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Faber
authors.forename: Jan-Christoph
authors.initials: JC
authors.lastname: Schoene-Bake
authors.forename: Peter
authors.initials: P
authors.lastname: Trautner
authors.forename: Marec
authors.initials: M
authors.lastname: von Lehe
authors.forename: Christian E
authors.initials: CE
authors.lastname: Elger
authors.forename: Bernd
authors.initials: B
authors.lastname: Weber
mesh_terms: D000328:Adult; D016880:Anisotropy; D038481:Anterior Temporal Lobectomy / Q000009:adverse effects*; D003627:Data Interpretation, Statistical; D038524:Diffusion Magnetic Resonance Imaging; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000601:surgery*; D005260:Female; D020712:Fornix, Brain / Q000473:pathology; D006179:Gyrus Cinguli / Q000473:pathology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009434:Neural Pathways / Q000473:pathology*; D009473:Neuronal Plasticity / Q000502:physiology; D011183:Postoperative Complications / Q000473:pathology*; D012686:Septal Nuclei / Q000473:pathology; D013702:Temporal Lobe / Q000601:surgery*