title: Descriptive epidemiology of rotavirus infection in a community in North India.
abstract: In India, rotavirus infections cause the death of 98621 children each year. In urban neighbourhoods in Delhi, children were followed up for 1 year to estimate the incidence of rotavirus gastroenteritis and common genotypes. Infants aged f1 week were enrolled in cohort 1 and infants aged 12 months (up to +14 days) in cohort 2. Fourteen percent (30/210) gastroenteritis episodes were positive for rotavirus. Incidence rates of rotavirus gastroenteritis episodes in the first and second year were 0.18 [95% confidence interval (CI) 0.10–0.27] and 0.14 (95% CI 0.07–0.21) episodes/child-year, respectively. The incidence rate of severe rotavirus gastroenteritis in the first year of life was 0.05 (95% CI 0.01–0.10) episodes/child-year. There were no cases in the second year. The common genotypes detected were G1P[8] (27%) and G9P[4] (23%). That severe rotavirus gastroenteritis is common in the first year of life is relevant for planning efficacy trials.
authors.affiliation: Centre for Health Research and Development, Society for Applied Studies, New Delhi, India.
authors.forename: T R
authors.initials: TR
authors.lastname: Chandola
authors.forename: S
authors.initials: S
authors.lastname: Taneja
authors.forename: N
authors.initials: N
authors.lastname: Goyal
authors.forename: S S
authors.initials: SS
authors.lastname: Rathore
authors.forename: M B
authors.initials: MB
authors.lastname: Appaiahgari
authors.forename: A
authors.initials: A
authors.lastname: Mishra
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Vrati
authors.forename: N
authors.initials: N
authors.lastname: Bhandari
mesh_terms: D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005500:Follow-Up Studies; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D007443:Intussusception / Q000453:epidemiology / Q000821:virology; D012401:Rotavirus / Q000235:genetics / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology; D012621:Seasons; D012720:Severity of Illness Index