title: Genetic, structural and functional imaging biomarkers for early detection of conversion from MCI to AD.
abstract: With the advent of advanced imaging techniques, genotyping, and methods to assess clinical and biological progression, there is a growing need for a unified framework that could exploit information available from multiple sources to aid diagnosis and the identification of early signs of Alzheimer's disease (AD). We propose a modeling strategy using supervised feature extraction to optimally combine high-dimensional imaging modalities with several other low-dimensional disease risk factors. The motivation is to discover new imaging biomarkers and use them in conjunction with other known biomarkers for prognosis of individuals at high risk of developing AD. Our framework also has the ability to assess the relative importance of imaging modalities for predicting AD conversion. We evaluate the proposed methodology on the Alzheimer's Disease Neuroimaging Initiative (ADNI) database to predict conversion of individuals with mild cognitive impairment (MCI) to AD, only using information available at baseline.
authors.affiliation: University of Utah, Salt Lake City, UT, USA. nikhil@cs.utah.edu
authors.forename: Nikhil
authors.initials: N
authors.lastname: Singh
authors.forename: Angela Y
authors.initials: AY
authors.lastname: Wang
authors.forename: Preethi
authors.initials: P
authors.lastname: Sankaranarayanan
authors.forename: P Thomas
authors.initials: PT
authors.lastname: Fletcher
authors.forename: Sarang
authors.initials: S
authors.lastname: Joshi
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000175:diagnosis*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001057:Apolipoproteins E / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D001921:Brain / Q000473:pathology; D060825:Cognitive Dysfunction / Q000175:diagnosis*; D016208:Databases, Factual; D003952:Diagnostic Imaging / Q000379:methods; D018450:Disease Progression; D005838:Genotype; D006801:Humans; D016018:Least-Squares Analysis; D008962:Models, Theoretical; D009474:Neurons / Q000473:pathology; D010446:Peptide Fragments / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000379:methods; D012307:Risk Factors
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D015415:Biomarkers; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)