title: Cell migration: cooperation between myosin II isoforms in durotaxis.
abstract: A new study reveals that non-muscle myosin II plays a central role in the durotaxis of mesenchymal stem cells, with the two major isoforms, II-A and II-B, being cooperatively required for this cell movement, and serine phosphorylation of the II-A isoform playing a negative role.
authors.affiliation: Ramón y Cajal Program, Universidad Autonoma de Madrid School of Medicine, Servicio de Inmunología, Hospital Universitario de la Princesa, Madrid, Spain. miguel.vicente@uam.es
authors.forename: Miguel
authors.initials: M
authors.lastname: Vicente-Manzanares
authors.forename: Miguel
authors.initials: M
authors.lastname: Vicente Manzanares
mesh_terms: D002465:Cell Movement; D016764:Cell Polarity; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D024507:Nonmuscle Myosin Type IIA / Q000378:metabolism*; D024501:Nonmuscle Myosin Type IIB / Q000378:metabolism*
chemical_list: D024507:Nonmuscle Myosin Type IIA; D024501:Nonmuscle Myosin Type IIB