title: Structural aspects of gut peptides with therapeutic potential for type 2 diabetes.
abstract: Gut hormones represent a niche subset of pharmacologically active agents that are rapidly gaining importance in medicine. Due to their exceptional specificity for their receptors, these hormones along with their analogues have attracted considerable pharmaceutical interest for the treatment of human disorders including type 2 diabetes. With the recent advances in the structural biology, a significant amount of structural information for these hormones is now available. This Minireview presents an overview of the structural aspects of these hormones, which have roles in physiological processes such as insulin secretion, as well as a discussion on the relevant structural modifications used to improve these hormones for the treatment of type 2 diabetes.
authors.affiliation: School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. Chandralal.Hewage@ucd.ie
authors.forename: Chandralal M
authors.initials: CM
authors.lastname: Hewage
authors.forename: Kalyana C
authors.initials: KC
authors.lastname: Venneti
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005749:Gastric Inhibitory Polypeptide / Q000737:chemistry / Q000627:therapeutic use; D005768:Gastrointestinal Hormones / Q000737:chemistry / Q000627:therapeutic use*; D005934:Glucagon / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D052216:Glucagon-Like Peptide 1 / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000737:chemistry / Q000627:therapeutic use; D014660:Vasoactive Intestinal Peptide / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D005768:Gastrointestinal Hormones; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D014660:Vasoactive Intestinal Peptide; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1; D005934:Glucagon