title: Cell-penetrating peptides: from cell cultures to in vivo applications.
abstract: The field of gene therapy is starting to move towards clinical applications but is currently limited by the lack of efficient delivery systems. Cell-penetrating peptides provide a means of cellular delivery for gene therapy applications as well as delivery of traditional drugs. Using cell-penetrating peptides a range of different cargoes have been successfully delivered into a number of cell types, in vitro as well as in vivo. In this review we discuss uptake mechanisms of different cell-penetrating peptides, with or without cargo. The transition from in vitro to in vivo applications and strategies to increase the bioavailability of cell-penetrating peptides are also discussed.
authors.affiliation: Department of Neurochemistry, Stockholm University, Svante Arrhenius väg 21A, SE-10691 Stockholm, Sweden.
authors.forename: Jakob
authors.initials: J
authors.lastname: Regberg
authors.forename: Jonas N K
authors.initials: JN
authors.lastname: Eriksson
authors.forename: Ulo
authors.initials: U
authors.lastname: Langel
mesh_terms: D001682:Biological Availability; D057846:Cell-Penetrating Peptides / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D053758:Nanoparticles; D051116:Receptors, Scavenger / Q000378:metabolism*
chemical_list: D057846:Cell-Penetrating Peptides; D051116:Receptors, Scavenger