title: STIM1 and Orai in cardiac hypertrophy and vascular proliferative diseases.
abstract: Cardiac hypertrophy and vascular proliferative diseases are associated with major alterations in calcium homeostasis and calcium signaling. The recent discovery of STIM and Orai has generated great enthusiasm concerning the role of these proteins in the cardiovascular system. We will review the major results concerning the existence and the role of these proteins in the cardiovascular system in normal and pathological situations and their implication in cardiovascular remodeling.
authors.affiliation: Inserm UMRS 956, Faculte de Médecine Pitie-salpetriere, Paris, France. anne-marie.lompre@upmc.fr
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Lompre
authors.forename: Ludovic
authors.initials: L
authors.lastname: Benard
authors.forename: Ypuakim
authors.initials: Y
authors.lastname: Saliba
authors.forename: Fleur
authors.initials: F
authors.lastname: Aubart
authors.forename: Jeremy
authors.initials: J
authors.lastname: Fauconnier
authors.forename: Jean-Sebastien
authors.initials: JS
authors.lastname: Hulot
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D006332:Cardiomegaly / Q000378:metabolism* / Q000473:pathology; D006706:Homeostasis; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D002118:Calcium