title: Mathematical modeling of the immune system recognition to mammary carcinoma antigen.
abstract: The definition of artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease. The present paper deals with an improved version of a mathematical model recently analyzed and related to the competition between immune system cells and mammary carcinoma cells under the action of a vaccine (Triplex). The model describes in detail both the humoral and cellular response of the immune system to the tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The control of the tumor cells growth occurs through the definition of different vaccine protocols. The performed numerical simulations of the model are in agreement with in vivo experiments on transgenic mice.
authors.affiliation: Dipartimento di Matematica e Informatica, Università di Catania, Catania, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Bianca
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Chiacchio
authors.forename: Francesco
authors.initials: F
authors.lastname: Pappalardo
authors.forename: Marzio
authors.initials: M
authors.lastname: Pennisi
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology; D003198:Computer Simulation; D007107:Immune System / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic; D018448:Models, Immunological; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D018719:Erb-b2 Receptor Tyrosine Kinases; C055984:mammary carcinoma antigen