title: Disseminated superficial actinic porokeratosis.
abstract: Disseminated superficial actinic porokeratosis, which was described in 1966, is characterized by small, atrophic patches with distinctive keratin rims that occur on sun-exposed areas of the extremities, shoulders, and back. The diagnosis is based on the histopathologic finding of a cornoid lamella, absence of a granular layer, and often a thin epidermis. It is associated with exposure to ultraviolet radiation. Gene studies suggest a pathway defect in which several mutations in keratinocyte proliferation and differentiation lead to development of porokeratosis.
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.
authors.forename: Panta
authors.initials: P
authors.lastname: Rouhani
authors.forename: Max
authors.initials: M
authors.lastname: Fischer
authors.forename: Shane
authors.initials: S
authors.lastname: Meehan
authors.forename: Miriam Keltz
authors.initials: MK
authors.lastname: Pomeranz
mesh_terms: D004890:Erythema / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D017499:Porokeratosis / Q000473:pathology*