title: The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients.
abstract: OBJECTIVE
  The study is to explore the histopathological features and the molecular marker expression of young women with breast cancers.
  
  
  METHODS
  The pathological data of 367 cases of female breast cancer patients were retrospectively analyzed, focusing on the analysis of young breast cancer incidence trends and the clinical and pathological features.
  
  
  RESULTS
  Compared with elderly breast cancer patients, young women with breast cancers had larger tumor sizes, higher histological grades, and lymph node metastasis rates. The majority of patients were in the PTNM III stage, with the clinical and pathological features of strong invasiveness. The positive expression rate of the BRCA1 protein in the young group was higher than that in the old group. BRCA1 expression was positively correlated with the PTNM stage and axillary lymph node metastasis (P < 0.05).
  
  
  CONCLUSIONS
  The ectopic expression of BRCA1 is associated with the genesis, progression, and prognosis of young breast cancer patients.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1628000054838044.
authors.affiliation: School of Medicine, Shandong University, Jinan 250012, PR China. qinglizhang2012@163.com
authors.forename: Qingli
authors.initials: Q
authors.lastname: Zhang
authors.forename: Qinghui
authors.initials: Q
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Cong
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D019313:BRCA1 Protein / Q000032:analysis* / Q000235:genetics; D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001943:Breast Neoplasms / Q000737:chemistry* / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008207:Lymphatic Metastasis; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D047368:Tumor Burden; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D014408:Biomarkers, Tumor