title: Antiproliferative oleanane saponins from Dizygotheca elegantissima.
abstract: Four new oleanane saponins (1-4), together with three known saponins, were isolated from the aerial parts of Dizygotheca elegantissima R. Vig. & Guillaumin. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all isolated compounds was evaluated.
authors.affiliation: Dipartimento di Chimica, Università degli Studi della Basilicata, Viale dell'Ateneo Lucano, 85100 Potenza, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Vassallo
authors.forename: Mariasabina
authors.initials: M
authors.lastname: Pesca
authors.forename: Letizia
authors.initials: L
authors.lastname: Ambrosio
authors.forename: Nicola
authors.initials: N
authors.lastname: Malafronte
authors.forename: Nadia Dekdouk
authors.initials: ND
authors.lastname: Melle
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Dal Piaz
authors.forename: Lorella
authors.initials: L
authors.lastname: Severino
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027481:Araliaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D009828:Oleanolic Acid