title: Physicochemical properties and controlled drug release of microcapsules prepared by simple coacervation.
abstract: Ternary phase diagrams of gelatin-water-methanol, gelatin-water-ethanol, and gelatin-water-propanol systems were prepared to evaluate optimal coacervation. The results of their evaluation suggested that the optimal coacervation region expands with the hydrophobicity of the added poor solvent (methanol, ethanol, 1-propanol, and 2-propanol). Microcapsules prepared based on the optimal coacervation region differed in controlled drug release among poor solvents used even when the concentration of gelatin, a membrane component, is the same. Compared with microcapsules prepared using the gelatin-water-ethanol system, those prepared using the gelatin-water-propanol system showed a 34% decrease in the drug release rate 24h after the initiation of the drug release test. These results suggested that microcapsules prepared using gelatin-water-various lower alcohol systems can readily control drug release and can be a useful drug delivery system (DDS).
authors.affiliation: Department of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Shimokawa
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Saegusa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Wada
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Ishii
mesh_terms: D000433:1-Propanol / Q000737:chemistry; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D000431:Ethanol / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D000432:Methanol / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D002214:Capsules; D004364:Pharmaceutical Preparations; D014867:Water; D000431:Ethanol; D005780:Gelatin; D000433:1-Propanol; D000432:Methanol