title: Functional impairment in progressive supranuclear palsy.
abstract: OBJECTIVE
  The current study sought to describe the functional profiles of patients with early-stage progressive supranuclear palsy (PSP) in a large prospective, multisite study.
  
  
  METHODS
  Using data from 202 individuals meeting criteria for clinically definite or probable PSP, 3 functional scales were examined. Functional scores were then compared to measures of motor, cognition, and psychiatric symptoms.
  
  
  RESULTS
  Functional disability was high in early-stage PSP, with 100% of patients having less than perfect scores on all functional scales. Whereas functional scores tended not to be related to cognition or psychiatric symptoms, they were strongly related to motoric ratings.
  
  
  CONCLUSIONS
  Both clinically and in research settings, the definition of functional intactness/impairment has important implications. Future studies should examine if functional impairment is this high in PSP or if new scales of functional abilities need to be developed for this condition.
authors.affiliation: Department of Neurology, University of Utah, Salt Lake City, USA. kevin.duff@hsc.utah.edu
authors.forename: Kevin
authors.initials: K
authors.lastname: Duff
authors.forename: Adam
authors.initials: A
authors.lastname: Gerstenecker
authors.forename: Irene
authors.initials: I
authors.lastname: Litvan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000502:physiology; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000209:etiology*; D008875:Middle Aged; D019957:Motor Skills Disorders / Q000209:etiology* / Q000503:physiopathology*; D011446:Prospective Studies; D012720:Severity of Illness Index; D013494:Supranuclear Palsy, Progressive / Q000150:complications* / Q000503:physiopathology*