title: Reproductive decision-making in young female carriers of a BRCA mutation.
abstract: OBJECTIVE
  How do young women, who were identified as carrying a BRCA gene mutation before they had children, approach reproductive decision-making and what are their attitudes towards reproductive genetic testing?
  
  
  CONCLUSIONS
  Reproductive decision-making within the context of cancer risk is complex and influenced by personal experiences of cancer. Younger women were not concerned with reproductive decision-making at the time of their genetic test; however, the impact on subsequent reproductive decision-making was considerable and left them with unanticipated dilemmas, such as having children who would be at risk of inheriting cancer predisposition, timing risk-reducing surgery and changing perceptions of responsibility.
  
  
  BACKGROUND
  Individuals carrying gene mutations predisposing to hereditary breast/ovarian cancer have concerns about passing on the gene mutation to children.
  
  
  METHODS
  Qualitative methodology and thematic analysis.
  
  
  METHODS
  Data were collected through semi-structured interviews with 25 women aged 18-45 who had received a positive result for a BRCA1 or BRCA2 gene mutation while childless.
  
  
  RESULTS
  Analysis revealed four central themes: (i) the impact of cancer on reproductive decision-making; (ii) motivation for genetic testing; (iii) risk management and timing of planning children; and (iv) optimism for future medical advancements.
  
  
  CONCLUSIONS
  This study explores the views of female BRCA carriers. Further research should explore the views of couples, men, and include samples with greater ethnic and social diversity.
  
  
  CONCLUSIONS
  This evidence highlights the need for reproductive decision-making to be addressed at the time of pretest genetic counselling. More information should be provided on reproductive options as well as counselling/support to guide women's reproductive decision-making and prenatal testing options at the time they undertake genetic testing.
  
  
  BACKGROUND
  This research was supported by Cancer Research UK (Number C1226 A7920) and NIHR support to the Biomedical Research Centre at The Institute of Cancer Research and RMH. The authors have no conflicts of interest to declare.
  
  
  BACKGROUND
  Not applicable.
authors.affiliation: Nightingale Centre and Genesis Prevention Centre, University Hospital of South Manchester, Manchester, UK.
authors.forename: L S
authors.initials: LS
authors.lastname: Donnelly
authors.forename: M
authors.initials: M
authors.lastname: Watson
authors.forename: C
authors.initials: C
authors.lastname: Moynihan
authors.forename: E
authors.initials: E
authors.lastname: Bancroft
authors.forename: D G R
authors.initials: DG
authors.lastname: Evans
authors.forename: R
authors.initials: R
authors.lastname: Eeles
authors.forename: S
authors.initials: S
authors.lastname: Lavery
authors.forename: E
authors.initials: E
authors.lastname: Ormondroyd
mesh_terms: D000293:Adolescent; D000328:Adult; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics / Q000523:psychology; D003657:Decision Making; D005260:Female; D020022:Genetic Predisposition to Disease / Q000523:psychology*; D005820:Genetic Testing; D006579:Heterozygote; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics / Q000523:psychology; D043762:Reproductive Behavior / Q000523:psychology*
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human