title: Safety and efficacy of intradermal injection of botulinum toxin for the treatment of oily skin.
abstract: OBJECTIVE
  To evaluate the safety and efficacy of intradermal injection of abobotulinumtoxinA for the treatment of oily skin.
  
  
  METHODS
  Twenty-five patients with oily skin were treated in the forehead region with intradermal injections of botulinum toxin. Baseline and post-treatment sebum production was measured using a sebometer. Photographs were taken. Patients were also asked to rate their satisfaction with the treatment in terms of improvement in their oily skin.
  
  
  RESULTS
  Treatment with botulinum toxin resulted in significantly lower sebum production at 1 week and 1, 2, and 3 months after injection (p < .001, t-test). Twenty-one patients (91%) reported that they were satisfied (50-75% improvement) with intradermal botulinum toxin as a treatment for oily skin. [Correction added after online publication 7-Jan-2013: the number of satisfied patients has been updated]
  
  
  CONCLUSIONS
  Intradermal injection of botulinum toxin significantly reduced sebum production in the forehead region, with a high degree of patient satisfaction. Intradermal botulinum toxin may be an effective treatment to reduce sebum production in patients with oily skin. Larger, randomized, blinded, placebo-controlled studies are warranted.
authors.affiliation: Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY 10022, USA.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Rose
authors.forename: David J
authors.initials: DJ
authors.lastname: Goldberg
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005546:Forehead; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012629:Sebum / Q000378:metabolism*; D012867:Skin / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D019274:Botulinum Toxins, Type A; C542869:abobotulinumtoxinA