title: Schisphenlignans A-E: five new dibenzocyclooctadiene lignans from Schisandra sphenanthera.
abstract: Five new dibenzocyclooctadiene lignans, schisphenlignans A-E (1-5), together with eight known ones, were isolated from the stems of Schisandra sphenanthera. The structures of 1-5 were elucidated based on the analysis of their NMR, MS and circular dichroism (CD) spectra. Some isolates were tested for their acute activities on insulin sensitivity in 3T3-L1 differentiated adipocytes, but none of them showed significant bioactivity with 10 µM administration of the tested compounds.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Cheng-Qin
authors.initials: CQ
authors.lastname: Liang
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shi
authors.forename: Shan-Zhai
authors.initials: SZ
authors.lastname: Shang
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.forename: Rui
authors.initials: R
authors.lastname: Zhan
authors.forename: Wen-Yong
authors.initials: WY
authors.lastname: Xiong
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Zhang
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D034242:Cyclooctanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D018547:Plant Stems / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*
chemical_list: D034242:Cyclooctanes; D007328:Insulin; D017705:Lignans; C511097:dibenzocyclooctadiene