title: Optical malignancy parameters for monitoring progression of breast cancer neoadjuvant chemotherapy.
abstract: We introduce and demonstrate use of a novel, diffuse optical tomography (DOT) based breast cancer signature for monitoring progression of neoadjuvant chemotherapy. This signature, called probability of malignancy, is obtained by statistical image analysis of total hemoglobin concentration, blood oxygen saturation, and scattering coefficient distributions in the breast tomograms of a training-set population with biopsy-confirmed breast cancers. A pilot clinical investigation adapts this statistical image analysis approach for chemotherapy monitoring of three patients. Though preliminary, the study shows how to use the malignancy parameter for separating responders from partial-responders and demonstrates the potential utility of the methodology compared to traditional DOT quantification schemes.
authors.affiliation: Dept. of Physics and Astronomy, University of Pennsylvania, 209 S. 33rd St., Philadelphia, PA 19104  USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Busch
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rosen
authors.forename: Wensheng
authors.initials: W
authors.lastname: Guo
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Michael D
authors.initials: MD
authors.lastname: Feldman
authors.forename: Carolyn
authors.initials: C
authors.lastname: Mies
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Czerniecki
authors.forename: Julia
authors.initials: J
authors.lastname: Tchou
authors.forename: Angela
authors.initials: A
authors.lastname: Demichele
authors.forename: Mitchell D
authors.initials: MD
authors.lastname: Schnall
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
keywords: (170.1610) Clinical applications; (170.3830) Mammography; (170.3880) Medical and biological imaging; (170.6510) Spectroscopy, tissue diagnostics