title: To be or not to be "TALL"?
abstract: Constitutional tall stature can be anticipated from neonatal length (1) and measurement at age 4 and 8 years (2). Mainly of genetic origin (3) it has been shown that tall children and parents have high normal or higher than normal serum hGH and/or IGF-I levels. (4-6). Also in a healthy adult population a significant (p<0.005) association between height and serum IGF-I has been reported (7). These within normal variations in "healthy" individuals should be distinguished from "gigantism" due to excessive GHR-H or hGH secretion (8, 9) and other pathological conditions leading to tall stature (3).
authors.affiliation: Endocrinology & Diabetes Research Unit, WHO Collaborative Center for Diabetes in Youth, Schneider Children's Medical Center, Petach Tikva, Israel. laronz@clalit.org.il
authors.forename: Zvi
authors.initials: Z
authors.lastname: Laron
mesh_terms: D001827:Body Height / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D006130:Growth Disorders / Q000188:drug therapy* / Q000453:epidemiology*; D019382:Human Growth Hormone / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D012945:Social Values
chemical_list: D019382:Human Growth Hormone