title: The evolutionary role of the IL-33/ST2 system in host immune defence.
abstract: Interleukin (IL)-33 is a recently identified pleiotropic cytokine, which can orchestrate complex innate and adaptive immune responses in immunity and disease. It has been characterized as a cytokine of the IL-1 family and affects a wide range of immune cells by signalling through its receptor ST2L. Accumulating evidence suggests a crucial role of IL-33/ST2 in inducing and modifying host immune responses against a variety of pathogens including parasites, bacteria, viruses and fungi as well as sterile insults of both endogenous and exogenous source. In this review, we endeavour to give a comprehensive overview of the current knowledge about the role of IL-33 and its receptor ST2 in host defence against infections.
authors.affiliation: Department of Medicine, Centre for Complement and Inflammation Research, Imperial College London, Hammersmith Campus, Du Cane Road, W12 0NN London, UK. s.sattler@imperial.ac.uk
authors.forename: Susanne
authors.initials: S
authors.lastname: Sattler
authors.forename: Hermelijn H
authors.initials: HH
authors.lastname: Smits
authors.forename: Damo
authors.initials: D
authors.lastname: Xu
authors.forename: Fang-Ping
authors.initials: FP
authors.lastname: Huang
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D005075:Biological Evolution; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology*
chemical_list: C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D007375:Interleukin-1; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins; D011956:Receptors, Cell Surface