title: [Relationship of toll-like receptors 2 and 4 genes polymorphisms with allergic diseases with increased levels of specific IgE].
abstract: The aim of the research was to identify the role of genes polymorphisms encoding TLR2 (NP_003255.2) and TLR4 (NP_612564.1) in the increase of the specific IgE production level and development of allergic diseases. Genetic typing of genome specific regions was performed by polymerase chain reaction method using specific oligonucleotide primers. The obtained results display that the most significant causative allergens are epidermal and household allergens (epidermis of cat, dog and horse, D. farinae, D. pteronyssinus). The relationship of polymorphisms TLR2 (rs5743708) and TLR4 (rs4986790) with increased production of specific IgE in patients with allergic diseases was also observed.
authors.forename: N L
authors.initials: NL
authors.lastname: Kutsenko
authors.forename: O V
authors.initials: OV
authors.lastname: Izmaĭlova
authors.forename: L È
authors.initials: LÈ
authors.lastname: Vesnina
authors.forename: I P
authors.initials: IP
authors.lastname: Kaĭdashev
mesh_terms: D000485:Allergens / Q000276:immunology; D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics* / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*
chemical_list: D000485:Allergens; C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D007073:Immunoglobulin E