title: Lighting up GPCRs with a fluorescent multiprobe dubbed "Snifit".
abstract: Shedding light on GPCRs: A milestone in analyzing GPCRs, GABA-Snifit, reported by the Johnsson lab, integrates the advantages of both protein tags and fluorescent ligands. This cutting-edge technology opens up an avenue to the generation of GPCR-based fluorescent sensors, thus accelerating further study of GPCRs.
authors.affiliation: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, 44 Wenhua Rd W, Jinan, Shandong 250012, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Ma
authors.forename: Lupei
authors.initials: L
authors.lastname: Du
authors.forename: Minyong
authors.initials: M
authors.lastname: Li
mesh_terms: D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008024:Ligands; D015335:Molecular Probes / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000737:chemistry; D005680:gamma-Aminobutyric Acid / Q000737:chemistry* / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D008024:Ligands; D015335:Molecular Probes; D043562:Receptors, G-Protein-Coupled; D011993:Recombinant Fusion Proteins; D005680:gamma-Aminobutyric Acid