title: Himeic acids E-G, new 4-pyridone derivatives from a culture of Aspergillus sp.
abstract: Three new himeic acids E-G were isolated from a marine-derived fungus, Aspergillus sp., and their structures were determined by spectroscopic analysis. Although himeic acid A inhibited the activity of ubiquitin-activating enzyme (E1), the three new derivatives did not.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kuwana
authors.forename: Mitsue
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kato
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
mesh_terms: D001230:Aspergillus / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011728:Pyridones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011753:Pyrones / Q000494:pharmacology; D044764:Ubiquitin-Activating Enzymes / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D005231:Fatty Acids, Unsaturated; D011728:Pyridones; D011753:Pyrones; C500027:himeic acid A; C534143:4-pyridone; D044764:Ubiquitin-Activating Enzymes