title: Preparation and in vitro percutaneous penetration of simvastatin ethosome gel.
abstract: To prepare ethosome gel containing simvastatin ethosome and investigate the permeation behavior of simvastatin from ethosome gel. Cumulative permeation quantity in unit area and intradermal retention were the indicators to evaluate the effects of simvastatin in vitro percutaneous permeation behavior. Cumulative permeation quantity in unit area of simvastatin ethosome gel was significantly higher than other agents (P < 0.05), the intradermal retention of simvastatin ethosome gel, simvastatin gel containing 1%, and 3% menthol were significantly higher than simvastatin gel (P < 0.05). Ethosome gel could enhance the skin permeation and accumulation in a depot of simvastatin.
authors.affiliation: Medical college, Qingdao University , Qingdao, P.R. China.
authors.forename: Keyao
authors.initials: K
authors.lastname: An
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Haicheng
authors.initials: H
authors.lastname: Yuan
authors.forename: Zhaoyuan
authors.initials: Z
authors.lastname: Cui
authors.forename: Lisa
authors.initials: L
authors.lastname: Xu
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D003324:Coronary Artery Disease / Q000188:drug therapy*; D016503:Drug Delivery Systems; D005782:Gels / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D019821:Simvastatin / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012867:Skin / Q000378:metabolism*; D053835:Unilamellar Liposomes / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D005782:Gels; D053835:Unilamellar Liposomes; D019821:Simvastatin