title: [Description of the hemodynamic and respiratory effects of hemoperfusion treatment with polymyxin B in patients with abdominal septic shock].
abstract: The objective of this study is to describe the hemodynamic effects, inotropic and vasoactive drug dependence, and to analyze the PO2/FiO2 ratio in 13 patients with septic shock of abdominal origin after hemoperfusion treatment with polymyxin-B. Treatment with polymyxin hemoperfusion therapy is indicated for patients with severe sepsis/septic shock of abdominal origin who do not respond adequately to conventional therapy. Two complete cycles with polymyxin cartridge were performed on 11 of the 13 patients, and a single cycle on the other O2. After treatment, the mean airway pressure (MAP) was increased (P=.003), the need for norepinephrine decreased (P=.003), and the PO2/FiO2 ratio increased (P=.02). The use of polymyxin hemoperfusion in patients with septic shock of intra-abdominal origin can significantly improve hemodynamic and respiratory functions.
authors.affiliation: Servicio de Anestesiología y Reanimación, Hospital Universitario La Princesa, Madrid, España. r_navarro_suay@yahoo.es
authors.forename: R
authors.initials: R
authors.lastname: Navarro
authors.forename: M
authors.initials: M
authors.lastname: Guerrero
authors.forename: M
authors.initials: M
authors.lastname: González
authors.forename: L
authors.initials: L
authors.lastname: Quecedo
authors.forename: A
authors.initials: A
authors.lastname: García
authors.forename: F
authors.initials: F
authors.lastname: Ramasco
mesh_terms: D000005:Abdomen; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006439:Hemodynamics / Q000187:drug effects*; D006464:Hemoperfusion; D006801:Humans; D008875:Middle Aged; D011112:Polymyxin B / Q000627:therapeutic use*; D012119:Respiration / Q000187:drug effects*; D012189:Retrospective Studies; D012772:Shock, Septic / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D011112:Polymyxin B