title: (68)Ga-DotaTATE PET-CT followed by Peptide Receptor Radiotherapy in combination with capecitabine in two patients with Merkel Cell Carcinoma.
abstract: Herein, we report about two Caucasian patients with the histopathological diagnosis of Merkel cell carcinoma suffering from extensive lymph node metastases. The extent of the disease was diagnosed by Ga-68-DotaTATE-PET-CT. Both patients had rapid disease progression, one of them despite a three months course of sunitinibe followed by four chemotherapy cycles of cisplatin and etoposide. Both patients were sent for peptide receptor radiotherapy with 90Y-DotaTATE or 177Lu-DotaTATE in combination with capecitabine. Additional external beam radiotherapy of the cervical and inguinal lymph nodes was given to the patient with progressive disease despite chemotherapy. Temporary partial response in both patients was achieved. Despite extensive therapeutic efforts, fatal outcome could not be prevented 10 and 14 months after first clinical symptoms.
authors.affiliation: Department of Nuclear Medicine, University Hospital of Cologne Germany.
authors.forename: Matthias C
authors.initials: MC
authors.lastname: Schmidt
authors.forename: Klara
authors.initials: K
authors.lastname: Uhrhan
authors.forename: Birgid
authors.initials: B
authors.lastname: Markiefka
authors.forename: Laura
authors.initials: L
authors.lastname: Hasselbring
authors.forename: Max
authors.initials: M
authors.lastname: Schlaak
authors.forename: Birgit
authors.initials: B
authors.lastname: Cremer
authors.forename: Sabine
authors.initials: S
authors.lastname: Kunze
authors.forename: Richard P
authors.initials: RP
authors.lastname: Baum
authors.forename: Markus
authors.initials: M
authors.lastname: Dietlein
keywords: 177Lu-DotaTATE; 68Ga-DotaTATE; 90Y-DotaTATE; Merkel cell carcinoma (MCC); PET-CT; Peptide Receptor Radiotherapy (PRRT); Theranostic