title: Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential.
abstract: Histone-modifying enzymes have recently been shown to play a central role in the regulation of both normal and malignant hematopoiesis. Post-translational modifications of histones and non-histone proteins underlies a regulatory complexity affecting numerous processes including transcriptional regulation, RNA processing and DNA damage response. Insights into the functions of these enzymes as well as their role in the epigenetic alterations found in leukemia will guide the development of novel therapeutic approaches. This review discusses examples of the proteins that have been implicated in the pathogenesis of leukemia, that may serve as potential therapeutic targets.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Ly P
authors.initials: LP
authors.lastname: Vu
authors.forename: Luisa
authors.initials: L
authors.lastname: Luciani
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Nimer
mesh_terms: D000818:Animals; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006655:Histone Deacetylases / Q000378:metabolism*; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism; D008745:Methylation; D010766:Phosphorylation; D054730:Protein Interaction Domains and Motifs; D011496:Protein Methyltransferases / Q000378:metabolism*
chemical_list: D006657:Histones; D011496:Protein Methyltransferases; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases