title: Pregnancy disorders appear to modify the risk for retinopathy of prematurity associated with neonatal hyperoxemia and bacteremia.
abstract: OBJECTIVE
  To explore (1) whether extremely low gestational age newborns exposed to inflammation-associated pregnancy disorders differ in retinopathy of prematurity (ROP) risk from infants exposed to placenta dysfunction-associated disorders, and (2) whether ROP risk associated with postnatal hyperoxemia and bacteremia differs among infants exposed to these disorders.
  
  
  METHODS
  Pregnancy disorders resulting in preterm birth include inflammation-associated: preterm labor, prelabor premature rupture of membranes (pPROM), cervical insufficiency, and abruption and placenta dysfunction-associated: preeclampsia and fetal indication. The risk of severe ROP associated with pregnancy disorders was evaluated by multivariable analyses in strata defined by potential effect modifiers, postnatal hyperoxemia and bacteremia.
  
  
  RESULTS
  Compared to preterm labor, infants delivered after pPROM were at reduced risk of plus disease (Odds ratio = 0.4, 95% confidence interval: 0.2-0.8) and prethreshold/threshold ROP (0.5, 0.3-0.8). Infants delivered after abruption had reduced risk of zone I ROP (0.2, 0.1-0.8) and prethreshold/threshold ROP (0.3, 0.1-0.7). In stratified analyses, infants born after placenta dysfunction had higher risks of severe ROP associated with subsequent postnatal hyperoxemia and bacteremia than infants born after inflammation-associated pregnancy disorders.
  
  
  CONCLUSIONS
  Infants exposed to placenta dysfunction have an increased risk of severe ROP following postnatal hyperoxemia and bacteremia compared to infants exposed to inflammation-associated pregnancy disorders.
authors.affiliation: Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, MA 02111, USA . Jlee9@tuftsmedicalcenter.org
authors.forename: Jennifer W
authors.initials: JW
authors.lastname: Lee
authors.forename: Thomas
authors.initials: T
authors.lastname: McElrath
authors.forename: Minghua
authors.initials: M
authors.lastname: Chen
authors.forename: David K
authors.initials: DK
authors.lastname: Wallace
authors.forename: Elizabeth N
authors.initials: EN
authors.lastname: Allred
authors.forename: Alan
authors.initials: A
authors.lastname: Leviton
authors.forename: Olaf
authors.initials: O
authors.lastname: Dammann
mesh_terms: D016470:Bacteremia / Q000453:epidemiology*; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D018496:Hyperoxia / Q000453:epidemiology*; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D012178:Retinopathy of Prematurity / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology