title: Microbial production of poly(hydroxybutyrate) from C₁ carbon sources.
abstract: Polyhydroxybutyrate (PHB) is an attractive substitute for petrochemical plastic due to its similar properties, biocompatibility, and biodegradability. The cost of scaled-up PHB production inhibits its widespread usage. Intensive researches are growing to reduce costs and improve thermomechanical, physical, and processing properties of this green biopolymer. Among cheap substrates which are used for reducing total cost of PHB production, some C₁ carbon sources, e.g., methane, methanol, and CO₂ have received a great deal of attention due to their serious role in greenhouse problem. This article reviews the fundamentals of strategies for reducing PHA production and moves on to the applications of several cheap substrates with a special emphasis on methane, methanol, and CO₂. Also, some explanation for involved microorganisms including the hydrogen-oxidizing bacteria and methanotrophs, their history, culture condition, and nutritional requirements are given. After description of some important strains among the hydrogen-oxidizing and methanotrophic producers of PHB, the article is focused on limitations, threats, and opportunities for application and their future trends.
authors.affiliation: Department of Food Technology Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Science, P.O. Box 19395-4741, Tehran, Iran. k.khosravi@nnftri.ac.ir
authors.forename: Kianoush
authors.initials: K
authors.lastname: Khosravi-Darani
authors.forename: Zahra-Beigom
authors.initials: ZB
authors.lastname: Mokhtari
authors.forename: Tomohito
authors.initials: T
authors.lastname: Amai
authors.forename: Kenji
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D002244:Carbon / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000378:metabolism*; D007218:Industrial Microbiology / Q000639:trends
chemical_list: D006885:Hydroxybutyrates; D002244:Carbon