title: New insights into associated co-morbidities in patients with cutaneous T-cell lymphoma (mycosis fungoides).
abstract: Studies of associated cancer in patients with mycosis fungoides (MF) have focused primarily on secondary cancers in North American and European populations. This study investigated the association between MF and malignancies, anxiety and depression in the Israeli population. Data on Israeli patients with MF and age- and gender-matched controls were collected from a database of population- based cohort (683 patients; 1,700 controls) and an institution- based cohort (343 patients; 846 controls) and analysed by univariate and multivariate methods. MF was significantly associated with Hodgkin's lymphoma in both cohorts (multivariate odds ratio (OR) 7.83, univariate OR ∞, respectively); acute leukaemia (multivariate OR 10.1, first cohort) and lung cancer (multivariate OR 10.15, second cohort). MF was significantly associated with anxiety and depression (multivariate OR 1.59, OR 1.51, respectively in first cohort). The current study provides support to the associations between MF and other cancers: Hodgkin's lymphoma, acute leukaemia and lung cancer. The study also emphasizes the association between MF and anxiety and depression.
authors.affiliation: Department of Dermatology, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel. hodake@post.tau.ac.il
authors.forename: Emmilia
authors.initials: E
authors.lastname: Hodak
authors.forename: Stuart
authors.initials: S
authors.lastname: Lessin
authors.forename: Rivka
authors.initials: R
authors.lastname: Friedland
authors.forename: Tamar
authors.initials: T
authors.lastname: Freud
authors.forename: Michael
authors.initials: M
authors.lastname: David
authors.forename: Lev
authors.initials: L
authors.lastname: Pavlovsky
authors.forename: Jonathan
authors.initials: J
authors.lastname: Shapiro
authors.forename: Arnon D
authors.initials: AD
authors.lastname: Cohen
mesh_terms: D001007:Anxiety / Q000453:epidemiology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007938:Leukemia / Q000453:epidemiology; D016015:Logistic Models; D008175:Lung Neoplasms / Q000453:epidemiology; D008297:Male; D015999:Multivariate Analysis; D009182:Mycosis Fungoides / Q000453:epidemiology*; D016017:Odds Ratio; D012878:Skin Neoplasms / Q000453:epidemiology*