title: Minimally invasive transdermal delivery of iron-dextran.
abstract: Iron deficiency is one of the most prevalent and serious health issues among people all over the world. Iron-dextran (ID) colloidal solution is one among the very few US Food and Drug Administration (FDA)-approved iron sources for parenteral administration of iron. Parenteral route does not allow frequent administration because of its invasiveness and other associated complications. The main aim of this project was to investigate the plausibility of transdermal delivery of ID facilitated by microneedles, as an alternative to parenteral iron therapy. In vitro permeation studies were carried out using freshly excised hairless rat abdominal skin in a Franz diffusion apparatus. Iron repletion studies were carried out in hairless anemic rat model. The anemic rats were divided into intact skin (control), microneedle pretreated, and intraperitoneal (i.p.) groups depending on the mode of delivery of iron. The hematological parameters were measured intermittently during treatment. There was no improvement in the hematological parameters in case of control group, whereas, in case of microneedle pretreated and i.p. group, there was significant improvement within 2-3 weeks. The results suggest that microneedle-mediated delivery of ID could be developed as a potential treatment method for iron-deficiency anemia.
authors.affiliation: Department of Pharmaceutics, University of Mississippi, University, Mississippi 38677, USA.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Juluri
authors.forename: Naresh
authors.initials: N
authors.lastname: Modepalli
authors.forename: Seongbong
authors.initials: S
authors.lastname: Jo
authors.forename: Michael A
authors.initials: MA
authors.lastname: Repka
authors.forename: H Nanjappa
authors.initials: HN
authors.lastname: Shivakumar
authors.forename: S Narasimha
authors.initials: SN
authors.lastname: Murthy
mesh_terms: D000279:Administration, Cutaneous; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000188:drug therapy*; D000818:Animals; D016503:Drug Delivery Systems / Q000295:instrumentation*; D006397:Hematinics / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007263:Infusions, Parenteral; D007505:Iron-Dextran Complex / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D054772:Rats, Hairless; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption
chemical_list: D006397:Hematinics; D007505:Iron-Dextran Complex