title: Risk factors and clinical analysis for invasive fungal infection in neonatal intensive care unit patients.
abstract: OBJECTIVE
  In this study, we seek to determine independent risk factors of invasive fungal infection (IFI) in neonatal infants.
  
  
  METHODS
  The medical charts of 5135 neonatal intensive care unit admissions in the past 7 years between January 2004 and December 2010 were reviewed and 45 neonates were found with IFI. Two controls, matched by gestational age, birth weight category, admission date, ward, hospital stay, and admission age, were selected for each case.
  
  
  RESULTS
  Candida parapsilosis was the leading causative pathogen of IFI and was isolated in 33.3% of the patients. The mortality rate of the case group was 8.9% versus 1.1% in controls (p < 0.05). Multivariable logistic regression modeling defined intubation > 6 days (71.1%), use of peripherally inserted central venous catheter (68.8%), use of third-generation cephalosporin (53.3%), any prior abdominal surgeries (20.0%), and neutropenia during first week of life < 1.5 · 109/L (20.0%) as exposures significantly associated with case status.
  
  
  CONCLUSIONS
  The predominant factors identified with IFI were third-generation cephalosporin use, peripherally inserted central venous catheter use, intubation > 6 days, any prior abdominal surgery, and neutropenia during first week of life < 1.5 · 109/L.
authors.affiliation: Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, PR China.
authors.forename: Yingfang
authors.initials: Y
authors.lastname: Yu
authors.forename: Lizhong
authors.initials: L
authors.lastname: Du
authors.forename: Tianming
authors.initials: T
authors.lastname: Yuan
authors.forename: Jiyan
authors.initials: J
authors.lastname: Zheng
authors.forename: An
authors.initials: A
authors.lastname: Chen
authors.forename: Lihua
authors.initials: L
authors.lastname: Chen
authors.forename: Liping
authors.initials: L
authors.lastname: Shi
mesh_terms: D000005:Abdomen / Q000601:surgery; D058387:Candidemia / Q000382:microbiology* / Q000401:mortality; D016022:Case-Control Studies; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002511:Cephalosporins / Q000009:adverse effects; D003428:Cross Infection / Q000382:microbiology* / Q000401:mortality; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000382:microbiology* / Q000401:mortality; D015931:Intensive Care, Neonatal; D007442:Intubation, Intratracheal / Q000009:adverse effects; D016015:Logistic Models; D016921:Meningitis, Fungal / Q000382:microbiology*; D015999:Multivariate Analysis; D009503:Neutropenia / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014552:Urinary Tract Infections / Q000382:microbiology
chemical_list: D002511:Cephalosporins