title: The association between cystatin C and incident type 2 diabetes is related to central adiposity.
abstract: BACKGROUND
  Cystatin C has recently been shown to be associated with incident type 2 diabetes. This study aims to validate this association and to study the impact of baseline adiposity.
  
  
  METHODS
  We investigated the 3-year diabetes incidence in 2849 participants from the French Data of an Epidemiological Study on the Insulin Resistance syndrome study, without overt kidney disease. Odds ratios (ORs) associated with cystatin C were adjusted for classical diabetes risk factors and interactions between cystatin C and these risk factors were studied.
  
  
  RESULTS
  Baseline serum cystatin C was significantly associated with incident diabetes on univariate analysis (OR/1 SD of log cystatin C: 1.74; 95% confidence interval [CI] 1.33-2.28; P=0.0001) and after adjustment for age and gender (OR 1.55; 95% CI 1.15-2.10; P=0.0039). This association was independent of serum creatinine-derived measures of baseline renal function and independent of fasting plasma glucose and HbA1c. When body mass index (BMI), waist circumference or baseline insulin resistance index were used as covariates, there was an interaction with cystatin C level. Cystatin C was associated only with incident diabetes for people with BMI, waist circumference or insulin resistance index≥median value with OR (95% CIs), respectively: 1.35 (0.98-1.84, P=0.0625); 1.39 (1.01-1.91, P=0.0441) and 1.41 (1.02-1.94, P=0.0398).
  
  
  CONCLUSIONS
  Cystatin C was associated with 3-year incident diabetes but only in people with central adiposity or insulin resistance. This should be considered in further studies assessing the clinical relevance of its prognostic value.
authors.affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Vic., Australia. anned.reutens@bakeridi.edu.au
authors.forename: Anne T
authors.initials: AT
authors.lastname: Reutens
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bonnet
authors.forename: Olivier
authors.initials: O
authors.lastname: Lantieri
authors.forename: Ronan
authors.initials: R
authors.lastname: Roussel
authors.forename: Beverley
authors.initials: B
authors.lastname: Balkau
mesh_terms: D050154:Adiposity; D000886:Anthropometry; D015415:Biomarkers / Q000378:metabolism; D015331:Cohort Studies; D055316:Cystatin C / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D005919:Glomerular Filtration Rate; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D007677:Kidney Function Tests; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D055316:Cystatin C
keywords: adiposity; cystatin C; diabetes; epidemiology; incidence