title: Recombinant protein polymers in biomaterials.
abstract: Naturally occurring protein-based materials have been found that function as critical components in biomechanical response, fibers and adhesives. A relatively small but growing number of recombinant protein-based materials that mimic the desired features of their natural sources, such as collagens, elastins and silks, are considered as an alternative to conventional synthetic polymers. Advances in genetic engineering have facilitated the synthesis of repetitive protein polymers with precise control of molecular weights which are designed by using synthetic genes encoding tandem repeats of oligopeptide originating from a modular domain of natural proteins. Many repeat sequences as protein polymer building blocks adopt a well-defined secondary structure and undergo self-assembly to result in physically cross-linked networks or with chemical cross-linking so that further form three-dimensional architectures similar to natural counterparts. In this review, recombinant protein polymers currently developed will be presented that have emerged as promising class of next generation biomaterials.
authors.affiliation: Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. wkim2@bidmc.harvard.edu
authors.forename: Wookhyun
authors.initials: W
authors.lastname: Kim
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis; D003094:Collagen / Q000737:chemistry; D004549:Elastin / Q000737:chemistry; D020724:Elastomers; D019476:Insect Proteins / Q000737:chemistry; D015202:Protein Engineering / Q000379:methods; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry; D011994:Recombinant Proteins; D020449:Repetitive Sequences, Amino Acid; D047011:Silk / Q000737:chemistry; D013112:Spiders
chemical_list: D001672:Biocompatible Materials; D020724:Elastomers; D019476:Insect Proteins; D011506:Proteins; D011994:Recombinant Proteins; D047011:Silk; C037403:adhesive protein, mussel; C030951:resilin; D003094:Collagen; D004549:Elastin