title: Postoperative analgesia in children after propofol versus sevoflurane anesthesia.
abstract: OBJECTIVE
  Postoperative analgesia remains a problem, especially in pediatric patients. We hypothesize that patients anesthetized with sevoflurane have more postoperative pain than with propofol.
  
  
  METHODS
  Randomized, prospective, double-blind study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  The subjects were 88 premedicated children, aged 3-6 years, and American Society of Anesthesiologists (ASA) Physical Status I or II.
  
  
  METHODS
  Subjectsunderwent hernia repair surgery.
  
  
  METHODS
  Anesthesia was maintained with propofol (group P, N = 46) or sevoflurane (group S, N = 42) and fentanyl was administered during surgery. All children before surgical incision received 40 mg/kg paracetamol, rectally. Prior to wound closure, the margins were infiltrated with 0.5% bupivacaine.
  
  
  METHODS
  The primary outcome was pain score assessed by Faces Pain Scale (FPS) 2 hours postoperatively. The secondary outcomes included recovery time and adverse events within the first 2 hours.
  
  
  RESULTS
  Group S had a significantly higher proportion of patients who exhibited postoperative pain than group P (24.3% vs 4.5%, respectively; P < 0.05). FPS score in group P was 1.2 ± 0.6, compared with 3.4 ± 1.5 in group S (P < 0.001). Mean recovery time in group S was significantly shorter than the corresponding mean for group P (10.1 ± 1.3 vs 16.5 ± 5.4 minutes, respectively; P < 0.001).
  
  
  CONCLUSIONS
  In children, anesthesia maintenance with propofol was associated with a significantly lower incidence of postoperative pain than with sevoflurane.
authors.affiliation: Department of Anesthesiology and Reanimation, University Clinical Centre of Kosova, Prishtina, Kosovo. antigona.hasani@gmail.com
authors.forename: Antigona
authors.initials: A
authors.lastname: Hasani
authors.forename: Agreta
authors.initials: A
authors.lastname: Gecaj-Gashi
authors.forename: Sadik
authors.initials: S
authors.lastname: Llullaku
authors.forename: Hysni
authors.initials: H
authors.lastname: Jashari
mesh_terms: D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000379:methods; D018681:Anesthetics, General / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use; D059685:Herniorrhaphy / Q000379:methods; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D015742:Propofol / Q000627:therapeutic use*; D000077149:Sevoflurane
chemical_list: D018681:Anesthetics, General; D008738:Methyl Ethers; D000077149:Sevoflurane; D005283:Fentanyl; D015742:Propofol