title: Transfer of extracellular vesicles during immune cell-cell interactions.
abstract: The transfer of molecules between cells during cognate immune cell interactions has been reported, and recently a novel mechanism of transfer of proteins and genetic material such as small RNA between T cells and antigen-presenting cells (APCs) has been described, involving exchange of extracellular vesicles (EVs) during the formation of the immunological synapse (IS). EVs, a term that encompasses exosomes and microvesicles, has been implicated in cell-cell communication during immune responses associated with tumors, pathogens, allergies, and autoimmune diseases. This review focuses on EV transfer as a mechanism for the exchange of molecules during immune cell-cell interactions.
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gutiérrez-Vázquez
authors.forename: Carolina
authors.initials: C
authors.lastname: Villarroya-Beltri
authors.forename: María
authors.initials: M
authors.lastname: Mittelbrunn
authors.forename: Francisco
authors.initials: F
authors.lastname: Sánchez-Madrid
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D054992:Immunological Synapses / Q000276:immunology*; D011506:Proteins / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D022142:Secretory Vesicles / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D011506:Proteins; D034741:RNA, Small Interfering