title: Clinical outcome of early glottic carcinoma in Serbia.
abstract: OBJECTIVE
  Proposed methods for treating early glottic carcinoma are cordectomy through laryngofissure, laser cordectomy, and radiotherapy. The aim of the study was to conduct comprehensive study to evaluate oncological and functional results of different treatment modalities for Tis and T1 glottic carcinoma, identify prognostic factors for the outcome of treatment and decide where we stand in applying worldwide standards of early glottic carcinoma treatment.
  
  
  METHODS
  Prospective study was conducted on 221 patients treated with Tis and T1 glottic carcinoma from 1998 to 2003 (72 patients were treated endoscopically with CO2 laser, 75 patients with cordectomy through laryngofissure and 74 with radiotherapy), with follow-up period from 38 to 107 months. Important demographic and clinical variables were analyzed. Voice quality after the treatment was assessed using multidimensional voice analysis.
  
  
  RESULTS
  Comparing oncological results of three modalities of treatment, there were no significant differences. Functional results of treatment were better after laser cordectomy and primary radiotherapy than following the open cordectomy. Five-year survival rate was almost identical in all three groups of patients, and important prognostic factors for survival were age and histological grade of the tumor.
  
  
  CONCLUSIONS
  Considering that the choice of treatment in our country is also greatly influenced by other paramedical factors, such as distance from treatment facility, reliability of follow-up, significant time delay of radiotherapy because of small number of radiology centers and strong patients' surgeon and treatment preference, we consider endoscopic laser surgery highly efficient and preferred choice of treatment for early glottic carcinoma.
authors.affiliation: Medical Faculty Belgrade, University of Belgrade, Serbia.
authors.forename: Jovica
authors.initials: J
authors.lastname: Milovanovic
authors.forename: Vojko
authors.initials: V
authors.lastname: Djukic
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Milovanovic
authors.forename: Ana
authors.initials: A
authors.lastname: Jotic
authors.forename: Bojan
authors.initials: B
authors.lastname: Banko
authors.forename: Snezana
authors.initials: S
authors.lastname: Jesic
authors.forename: Borivoj
authors.initials: B
authors.lastname: Babic
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Trivic
authors.forename: Vera
authors.initials: V
authors.lastname: Artiko
authors.forename: Milorad
authors.initials: M
authors.lastname: Petrovic
authors.forename: Predrag
authors.initials: P
authors.lastname: Stankovic
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000401:mortality / Q000628:therapy*; D018572:Disease-Free Survival; D061345:Early Medical Intervention; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000628:therapy*; D007825:Laryngectomy; D053685:Laser Therapy; D054020:Lasers, Gas / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D064887:Observational Studies as Topic; D011446:Prospective Studies; D011878:Radiotherapy; D055771:Serbia; D016896:Treatment Outcome; D014833:Voice Quality