title: The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.
abstract: THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring during late postembryonic stages.
authors.affiliation: Department of Molecular Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla, Sevilla, Spain.
authors.forename: Maikel
authors.initials: M
authors.lastname: Castellano-Pozo
authors.forename: Tatiana
authors.initials: T
authors.lastname: García-Muse
authors.forename: Andrés
authors.initials: A
authors.lastname: Aguilera
mesh_terms: D000818:Animals; D049628:Body Size; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D059447:Cell Cycle Checkpoints; D004249:DNA Damage; D004261:DNA Replication; D008938:Mitosis; D046912:Multiprotein Complexes / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D046912:Multiprotein Complexes; C577830:THOC-2 protein, C elegans; D014157:Transcription Factors