title: Computational and experimental investigation of molecular imprinted polymers for selective extraction of dimethoate and its metabolite omethoate from olive oil.
abstract: This work presents the development of molecularly imprinted polymers (MIPs) for the selective extraction of dimethoate from olive oil. Computational simulations allowed selecting itaconic acid as the monomer showing the highest affinity towards dimethoate. Experimental validation confirmed modelling predictions and showed that the polymer based on IA as functional monomer and omethoate as template molecule displays the highest selectivity for the structurally similar pesticides dimethoate, omethoate and monocrotophos. Molecularly imprinted solid phase extraction (MISPE) method was developed and applied to the clean-up of olive oil extracts. It was found that the most suitable solvents for loading, washing and elution step were respectively hexane, hexane-dichloromethane (85:15%) and methanol. The developed MIPSE was successfully applied to extraction of dimethoate from olive oil, with recovery rates up to 94%. The limits of detection and quantification of the described method were respectively 0.012 and 0.05 μg g(-1).
authors.affiliation: Université de Perpignan Via Domitia, IMAGES EA4218, 52 Av. Paul Alduy, F-66860 Perpignan cedex, France.
authors.forename: Idriss
authors.initials: I
authors.lastname: Bakas
authors.forename: Najwa Ben
authors.initials: NB
authors.lastname: Oujji
authors.forename: Ewa
authors.initials: E
authors.lastname: Moczko
authors.forename: Georges
authors.initials: G
authors.lastname: Istamboulie
authors.forename: Sergey
authors.initials: S
authors.lastname: Piletsky
authors.forename: Elena
authors.initials: E
authors.lastname: Piletska
authors.forename: Elhabib
authors.initials: E
authors.lastname: Ait-Addi
authors.forename: Ihya
authors.initials: I
authors.lastname: Ait-Ichou
authors.forename: Thierry
authors.initials: T
authors.lastname: Noguer
authors.forename: Régis
authors.initials: R
authors.lastname: Rouillon
mesh_terms: D004117:Dimethoate / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification*; D057230:Limit of Detection; D054802:Molecular Imprinting / Q000379:methods*; D000069463:Olive Oil; D010575:Pesticides / Q000737:chemistry / Q000302:isolation & purification*; D010938:Plant Oils / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D052616:Solid Phase Extraction / Q000379:methods*
chemical_list: D000069463:Olive Oil; D010575:Pesticides; D010938:Plant Oils; D011108:Polymers; C002302:dimethoxon; D004117:Dimethoate