title: The effects of subchronic d-serine on left-right discrimination learning, social interaction, and exploratory activity in APPswe/PS1 mice.
abstract: Glutamatergic neurotransmission is crucially involved in memory and cognition and severely affected patients with Alzheimer's disease. Modulation of NMDA receptors with agonists may reverse their late-stage symptoms. The effects of subchronic treatment of the NMDA receptor agonist, d-serine, were evaluated in APPswe/PS1 mutant mice harboring Aβ plaques in brain, regarding spatial discrimination learning, open-field activity, and social interaction in a three-chambered apparatus. d-serine (50mg/kg, i.p.) was superior to placebo in mutant mice during the reversal phase of left-right discrimination learning without affecting acquisition. The drug caused weaker effects in counteracting open-field hyperactivity and low social interaction with an unfamiliar stimulus mouse. These results indicate a favorable action of an NMDA receptor agonist on reversal learning in transgenic mice with amyloid pathology.
authors.affiliation: Department of Molecular Medicine, Laval University, Québec, Canada. Mohammed.Filali@crchul.ulaval.ca
authors.forename: Mohammed
authors.initials: M
authors.lastname: Filali
authors.forename: Robert
authors.initials: R
authors.lastname: Lalonde
mesh_terms: D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051379:Mice; D012694:Serine / Q000008:administration & dosage / Q000494:pharmacology*; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
chemical_list: D012694:Serine