title: [Psychotherapeutic and psychosocial interventions and endophenotypes in bipolar disorders].
abstract: Diseases with complex determinism, bipolar disorders, involve at the same time environmental and genetic factors of vulnerability. The characterization of these vulnerabilities would allow a better knowledge of their etiology and envisage the development of therapeutics, more specialized, even preventive. The research in genetic psychiatry allowed to highlight endophenotype candidates associated to bipolar disorders. They are endogenous clinical or biological features, biologically more elementary than phenotypes and more directly bound to the physiological consequences of genes and their polymorphisms. Targeting some of them with specific psychotherapy and psychosocial interventions could reduce the consequences of their expression and so have an action on the course of the disease and also preventive.
authors.affiliation: Pôle Universitaire de Psychiatrie, Hôpital Sainte-Marguerite, Marseille cedex 9, France. nadia.correard@ap-hm.fr
authors.forename: N
authors.initials: N
authors.lastname: Correard
authors.forename: S N
authors.initials: SN
authors.lastname: Elissalde
authors.forename: J-M
authors.initials: JM
authors.lastname: Azorin
authors.forename: E
authors.initials: E
authors.lastname: Fakra
authors.forename: R
authors.initials: R
authors.lastname: Belzeaux
mesh_terms: D001008:Anxiety Disorders / Q000235:genetics / Q000523:psychology / Q000628:therapy; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology / Q000628:therapy*; D002605:Character; D003072:Cognition Disorders / Q000235:genetics / Q000523:psychology / Q000628:therapy; D015928:Cognitive Behavioral Therapy; D058068:Endophenotypes; D005196:Family Therapy; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000523:psychology; D006801:Humans; D007175:Impulsive Behavior / Q000235:genetics / Q000523:psychology / Q000628:therapy; D000075384:Neuroticism; D010353:Patient Education as Topic; D011110:Polymorphism, Genetic / Q000235:genetics; D011379:Prognosis; D011613:Psychotherapy; D012073:Remedial Teaching; D012917:Social Adjustment; D012951:Socialization