title: Signalling pathways that inhibit the capacity of precursor cells for myelin repair.
abstract: In demyelinating disorders such as Multiple Sclerosis (MS), targets of injury are myelin and oligodendrocytes, leading to severe neurological dysfunction. Regenerative therapies aimed at promoting oligodendrocyte maturation and remyelination are promising strategies for treatment in demyelinating disorders. Endogenous precursor cells or exogenous transplanted cells are potential sources for remyelinating oligodendrocytes in the central nervous system (CNS). Several signalling pathways have been implicated in regulating the capacity of these cell populations for myelin repair. Here, we review neural precursor cells and oligodendrocyte progenitor cells as potential sources for remyelinating oligodendrocytes and evidence for the functional role of key signalling pathways in inhibiting regeneration from these precursor cell populations.
authors.affiliation: Centre for Neuroscience Research, Department of Anatomy and Neuroscience, University of Melbourne, Melbourne Brain Centre, Kenneth Myer Building, 30 Royal Parade, Parkville, Vic 3010, Australia. hcate@unimelb.edu.au.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Sabo
authors.forename: Holly S
authors.initials: HS
authors.lastname: Cate
mesh_terms: D000818:Animals; D017690:Cell Transplantation / Q000379:methods; D003711:Demyelinating Diseases / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D009103:Multiple Sclerosis / Q000503:physiopathology / Q000628:therapy; D009186:Myelin Sheath / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology; D058953:Neural Stem Cells / Q000502:physiology* / Q000637:transplantation; D009836:Oligodendroglia / Q000502:physiology / Q000637:transplantation; D015398:Signal Transduction