title: Modular 'click-in-emulsion' bone-targeted nanogels.
abstract: A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Heller
authors.forename: Yair
authors.initials: Y
authors.lastname: Levi
authors.forename: Jeisa M
authors.initials: JM
authors.lastname: Pelet
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Doloff
authors.forename: Jasmine
authors.initials: J
authors.lastname: Wallas
authors.forename: George W
authors.initials: GW
authors.lastname: Pratt
authors.forename: Shan
authors.initials: S
authors.lastname: Jiang
authors.forename: Gaurav
authors.initials: G
authors.lastname: Sahay
authors.forename: Avi
authors.initials: A
authors.lastname: Schroeder
authors.forename: Josh E
authors.initials: JE
authors.lastname: Schroeder
authors.forename: Yieu
authors.initials: Y
authors.lastname: Chyan
authors.forename: Christopher
authors.initials: C
authors.lastname: Zurenko
authors.forename: William
authors.initials: W
authors.lastname: Querbes
authors.forename: Miguel
authors.initials: M
authors.lastname: Manzano
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Kohane
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Anderson