title: Transient Myeloproliferative Disorder and Down Syndrome: Is there a link?
abstract: An extremely premature male neonate presented with an unusual multisystem dysfunction within the first 24 to 48 hours of life. The unfolding of clinical events and investigations revealed a transient myeloproliferative disorder (TMD). TMD was the main indication for karyotyping of this premature infant without clinical symptoms of Down syndrome. The awareness of TMD in a newborn warrants karyotype analysis to look for trisomy 21 and a close surveillance because of its potential progression to true leukaemia.
authors.affiliation: Departments of Child Health and.
authors.forename: Zenaida S
authors.initials: ZS
authors.lastname: Reyes
authors.forename: Wafa
authors.initials: W
authors.lastname: Bashir
authors.forename: Anil
authors.initials: A
authors.lastname: Pathare
keywords: Acute myelogenous leukemia (AML); Case report; Down syndrome; Extreme premature; GATA1; Oman; Transient myeloproliferative disorder