title: [Toxical research of Kudiezi injection in safety re-evaluation].
abstract: OBJECTIVE
  To explore the toxic effect on mouse administrated Kudiezi injection multy times a day, and on rats repeat administrated for many days.
  
  
  METHODS
  Mouse tail intravenous injection of Kudiezi, 0.04 mL x g(-1), 3 times a day, rats tail intravenous injection of Kudiezi, 20, 10, 4 mL x kg(-1), once a day, for 6 weeks.
  
  
  RESULTS
  There is no abnormal to the mouses administrated many times a day. The rats administrated large doses of drug for many days have certain effects on hematology, blood biochemistry. Some animals appear liver, kidney lesions mild, injection local appear haemorrhage, edema and inflammatory reaction.
  
  
  CONCLUSIONS
  The mouse which was intravenous injection in the dose of 180 times Kudiezi injection as much as people used, revealed no toxicity reaction. Repeated large-dose administration, rats caused by lesions of the main target organs may be for kidney, liver. But the recovery result on liver, kidney toxicity was reversible, no delayed toxicity. At the same time, large doses of long-term administration of local have a certain irritation. Tips the medication should be under the guidance of doctors, and pay attention to replace the injection site. This research will provide safety basis for the clinical use of Kudiezi injection.
authors.affiliation: Shenyang Shuangding Pharmaceutical Co., Ltd., Shenyang 110179, China. Zhiqiang3390@yahoo.com.cn
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Zhan
authors.forename: Yan-Peng
authors.initials: YP
authors.lastname: Chang
authors.forename: Xiu-Ying
authors.initials: XY
authors.lastname: Wang
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Li
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Yan
authors.forename: Han-Lian
authors.initials: HL
authors.lastname: Wei
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004358:Drug Therapy; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal