title: A prospective longitudinal study on rotation thromboelastometry in women with uncomplicated pregnancies and postpartum.
abstract: BACKGROUND
  Rotation thromboelastometry (ROTEM) is an easy, fast and complete method of measuring coagulation.
  
  
  OBJECTIVE
  Our goal was to obtain longitudinal values on ROTEM in uncomplicated pregnancies and in the puerperium.
  
  
  METHODS
  Healthy women, who visited our outpatient clinic for antenatal checks and who accomplished an uncomplicated pregnancy were tested three times during pregnancy and one time postpartum. Intrinsic and extrinsic pathway tests were carried out.
  
  
  RESULTS
  In total, 62 women were analysed, and 298 measurements were taken. With increasing gestational age, there are significant changes towards hypercoagulability.
  
  
  CONCLUSIONS
  This study provides a better knowledge about physiological changes in ROTEM measurements during pregnancy. These normative data may serve as assistance for future studies and interventions.
authors.affiliation: Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands. leonie_flach@hotmail.com
authors.forename: Leonie E
authors.initials: LE
authors.lastname: van Rheenen-Flach
authors.forename: Sonja
authors.initials: S
authors.lastname: Zweegman
authors.forename: Fleur
authors.initials: F
authors.lastname: Boersma
authors.forename: Joris E
authors.initials: JE
authors.lastname: Lenglet
authors.forename: Jos W R
authors.initials: JW
authors.lastname: Twisk
authors.forename: Antoinette C
authors.initials: AC
authors.lastname: Bolte
mesh_terms: D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D011181:Postnatal Care; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011264:Pregnancy Trimesters / Q000097:blood; D011295:Prenatal Care; D011446:Prospective Studies; D012016:Reference Values; D013916:Thrombelastography / Q000379:methods; D055815:Young Adult