title: Synthesis and characterization of selected methyl 5-methoxy-2-methyl-1-benzofuran-3-carboxylate derivatives with potential antimicrobial activity.
abstract: Halogen and aminoalkyl derivatives of methyl 5-methoxy-2-methyl-1-benzofuran-3-carboxylate were prepared using 5-hydroxy-2-methyl-3-benzofuranocarboxylic acid as starting material. (1)H-NMR spectra were obtained for all of the synthesized structures, and for compounds 1 and 2 X-ray crystal structures were obtained too. All derivatives were tested for antimicrobial activity against a selection of Gram-positive cocci, Gram-negative rods and yeasts.
authors.affiliation: Department of Medical Chemistry, Medical University of Warsaw, Poland. mariola.krawiecka@wum.edu.pl
authors.forename: Mariola
authors.initials: M
authors.lastname: Krawiecka
authors.forename: Bozena
authors.initials: B
authors.lastname: Kuran
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kossakowski
authors.forename: Irena
authors.initials: I
authors.lastname: Wolska
authors.forename: Marta
authors.initials: M
authors.lastname: Kierzkowska
authors.forename: Grazyna
authors.initials: G
authors.lastname: Młynarczyk
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D001572:Benzofurans