title: [Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants].
abstract: BACKGROUND
  Iron deficiency anemia is the most common nutritional deficiency in children under 2 years, affecting to 34.1% in Argentina. Iron supplementation is the standard treatment. The aim of our study was to evaluate the efficacy and tolerability of two iron containing drugs.
  
  
  METHODS
  Randomized, double-blind, controlled trial, including children aged 6 to 18 months with iron deficiency anemia (hemoglobin < 11 g/dl, transferrine saturation < 20%). Patients were randomly assigned to one of two treatments: iron polymaltose complex (IPC) or ferrous sulphate (FS). Efficacy, tolerance and adverse events occurrence were evaluated.
  
  
  RESULTS
  60 children with iron deficiency anemia were included; 29 in the FS group and 31 in the IPC group. There were no significant differences between groups regarding hemoglobin at baseline (10,09 ± 0,92 vs. 10,26 ± 0,41; p= 0,17) and after 90 days treatment (11,26 ± 0,49 vs. 11,14 ± 0,60; p= 0,21). Also, there were no differences regarding adverse events frequency (FS: 4/29 y IPC: 9/31; p=0,2).
  
  
  CONCLUSIONS
  In our study, there were no differences in efficacy and safety between FS and IPC in the treatment of children with iron deficiency anemia.
authors.affiliation: Servicio Hemato-Oncología, Hospital General de Niños Pedro de Elizalde, Ciudad de Buenos Aires. damaral@intramed.net
authors.forename: Diego
authors.initials: D
authors.lastname: Amaral
authors.forename: Griselda
authors.initials: G
authors.lastname: Galimberti
authors.forename: Soledad
authors.initials: S
authors.lastname: Cuesta
authors.forename: Juana
authors.initials: J
authors.lastname: Pinto
authors.forename: Claudia
authors.initials: C
authors.lastname: Ferrario
authors.forename: Elena
authors.initials: E
authors.lastname: Graciela
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy*; D004311:Double-Blind Method; D005290:Ferric Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D005296:Ferrous Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007223:Infant; D016896:Treatment Outcome
chemical_list: D005290:Ferric Compounds; D005296:Ferrous Compounds; C020748:ferrous sulfate