title: [Mechanism underlying the anterograde transport of the influenza A virus transmembrane proteins and genome in host cytoplasm].
abstract: Influenza virus assembly requires the completion of viral protein and vRNP transport to the assembly site at the plasma membrane. Therefore, efficient regulation of intracellular transport of the viral proteins and vRNPs to the surface of the host cell is especially important for virus morphogenesis. Influenza A virus uses the machineries of host cells to transport its own components including ribonucleoproteins (vRNPs) and three transmembrane proteins hemagglutinin (HA), neuraminidase (NA) and matrix 2 protein (M2). It has been shown that newly synthesized vRNPs are associated with active form of Rab11 and accumulate at recycling endosomes adjacent to the microtubule organizing center (MTOC) following nuclear export. Subsequently, they are transported along the microtubule network toward the plasma membranes in cargo vesicles. The viral transmembrane proteins are translated on the rough endoplasmic reticulum and transported to the virus assembly site at the plasma membrane. It has been found that several host factors such as ARHGAP21 and GTPase Cdc42 are involved in regulation of intracellular trafficking of influenza A virus transmembrane proteins including NA. In this review, we will highlight the current knowledge about anterograde transport and its regulation of the influenza A virus transmembrane proteins and genome in the host cytoplasm.
authors.affiliation: Department of Veterinary Medicine, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Chi
authors.forename: Song
authors.initials: S
authors.lastname: Wang
authors.forename: Yifan
authors.initials: Y
authors.lastname: Huang
authors.forename: Jilong
authors.initials: J
authors.lastname: Chen
mesh_terms: D003593:Cytoplasm / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000378:metabolism; D020690:GTPase-Activating Proteins / Q000378:metabolism; D016679:Genome, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000378:metabolism*; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D009439:Neuraminidase / Q000378:metabolism*; D021381:Protein Transport; D012261:Ribonucleoproteins / Q000378:metabolism*; D014763:Viral Matrix Proteins / Q000378:metabolism*; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D000086082:Viroporin Proteins
chemical_list: D020558:GTP Phosphohydrolases; D020690:GTPase-Activating Proteins; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D009439:Neuraminidase; D012261:Ribonucleoproteins; D014763:Viral Matrix Proteins; D020764:cdc42 GTP-Binding Protein; C459590:ARHGAP21 protein, human; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins; C483468:hemagglutinin, human influenza A virus