title: Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids.
abstract: The anthraquinone-sialic acid hybrids designed effectively degraded not only non-drug-resistant neuraminidase but also drug-resistant neuraminidase, which is an important target of anti-influenza therapy. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions. Moreover, the hybrids efficiently inhibited neuraminidase activities upon photo-irradiation.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Aoki
authors.forename: Shuho
authors.initials: S
authors.lastname: Tanimoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takahashi
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Toshima
mesh_terms: D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology; D004279:DNA, Viral / Q000187:drug effects / Q000528:radiation effects; D024882:Drug Resistance, Viral / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000201:enzymology*; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D009439:Neuraminidase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010782:Photolysis; D012794:Sialic Acids / Q000737:chemistry* / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D000880:Anthraquinones; D004279:DNA, Viral; D012794:Sialic Acids; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid