title: Subarachnoid Hemorrhage International Trialists data repository (SAHIT).
abstract: The outcome of patients with aneurysmal subarachnoid hemorrhage (SAH) has improved slowly over the past 25 years. This improvement may be due to early aneurysm repair by endovascular or open means, use of nimodipine, and better critical care management. Despite this improvement, mortality remains at about 40%, and many survivors have permanent neurologic, cognitive, and neuropsychologic deficits. Randomized clinical trials have tested pharmacologic therapies, but few have been successful. There are numerous explanations for the failure of these trials, including ineffective interventions, inadequate sample size, treatment side effects, and insensitive or inappropriate outcome measures. Outcome often is evaluated on a good-bad dichotomous scale that was developed for traumatic brain injury 40 years ago. To address these issues, we established the Subarachnoid Hemorrhage International Trialists (SAHIT) data repository. The primary aim of the SAHIT data repository is to provide a unique resource for prognostic analysis and for studies aimed at optimizing the design and analysis of phase III trials in aneurysmal SAH. With this aim in mind, we convened a multinational investigator meeting to explore merging individual patient data from multiple clinical trials and observational databases of patients with SAH and to create an agreement under which such a group of investigators could submit data and collaborate. We welcome collaboration with other investigators.
authors.affiliation: St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. macdonaldlo@smh.ca
authors.forename: R Loch
authors.initials: RL
authors.lastname: Macdonald
authors.forename: Michael D
authors.initials: MD
authors.lastname: Cusimano
authors.forename: Nima
authors.initials: N
authors.lastname: Etminan
authors.forename: Daniel
authors.initials: D
authors.lastname: Hanggi
authors.forename: David
authors.initials: D
authors.lastname: Hasan
authors.forename: Don
authors.initials: D
authors.lastname: Ilodigwe
authors.forename: Blessing
authors.initials: B
authors.lastname: Jaja
authors.forename: Hector
authors.initials: H
authors.lastname: Lantigua
authors.forename: Peter
authors.initials: P
authors.lastname: Le Roux
authors.forename: Benjamin
authors.initials: B
authors.lastname: Lo
authors.forename: Ada
authors.initials: A
authors.lastname: Louffat-Olivares
authors.forename: Stephan
authors.initials: S
authors.lastname: Mayer
authors.forename: Andrew
authors.initials: A
authors.lastname: Molyneux
authors.forename: Audrey
authors.initials: A
authors.lastname: Quinn
authors.forename: Tom A
authors.initials: TA
authors.lastname: Schweizer
authors.forename: Thomas
authors.initials: T
authors.lastname: Schenk
authors.forename: Julian
authors.initials: J
authors.lastname: Spears
authors.forename: Michael
authors.initials: M
authors.lastname: Todd
authors.forename: James
authors.initials: J
authors.lastname: Torner
authors.forename: Mervyn D I
authors.initials: MD
authors.lastname: Vergouwen
authors.forename: George K C
authors.initials: GK
authors.lastname: Wong
mesh_terms: D003299:Cooperative Behavior; D016208:Databases, Factual; D007391:International Cooperation; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D013345:Subarachnoid Hemorrhage / Q000628:therapy*; D016896:Treatment Outcome