title: [Clinical re-evaluation of effects of two different "cocktail therapy" to prevent from phlebitis induced by Chansu injection].
abstract: OBJECTIVE
  To re-evaluate the effects of different "cocktail therapy" to prevent from phlebitis induced by Chansu injection.
  
  
  METHODS
  Patients treated with Chansu injection were divided randomLy into 4 groups with 90 per group, control group, phentolaminum group, the magnesium sulfate group-phentolaminum group, and anisodamine-phentolaminum group. Patients in the control group only received the routine nursing treatment, and patients in the various experiment group received different interventions. The comparison was made in the morbidity and the starting time of occurrence of phlebitis, the severity of pain, duration of pain.
  
  
  RESULTS
  The morbidity of phlebitis was 8%, 8%, 6%, respectively. The starting time of phlebitis occurrence was (22 +/- 4), (27 +/- 5), (28 +/- 7) h, respectively. The NRS of pain was (4.75 +/- 1.51), (3.27 +/- 1.02), (2.71 +/- 1.63), respectively. The duration time of pain was (4.25 +/- 1.36), (2.51 +/- 1.05), (2.19 +/- 1.13) d respectively. In control group, the morbidity of phlebitis, the starting time of occurrence of phlebitis, the severity of pain, duration of pain was 30%, (16 +/- 4) h, (6.34 +/- 1.21), (5.47 +/- 1.07) d, respectively. As compared with the control group, a significance difference was found between every group in three test groups and control group respectively (P<0.05).
  
  
  CONCLUSIONS
  The morbidity and the starting time of occurrence of phlebitis, the severity of pain, duration of pain was significantly reduced respectively by two different "cocktail therapy".
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. drzhyubin@sina.com
authors.forename: Yu-Bin
authors.initials: YB
authors.lastname: Zhao
authors.forename: Zhe
authors.initials: Z
authors.lastname: Hao
authors.forename: Hong-Dan
authors.initials: HD
authors.lastname: Zhang
authors.forename: Yan-Ming
authors.initials: YM
authors.lastname: Xie
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001001:Anura; D002018:Bufanolides / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010646:Phentolamine / Q000627:therapeutic use; D010689:Phlebitis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D012991:Solanaceous Alkaloids / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D002018:Bufanolides; D012991:Solanaceous Alkaloids; C095591:chan su; C003922:anisodamine; D008278:Magnesium Sulfate; D010646:Phentolamine