title: Popcorn-shaped magnetic core-plasmonic shell multifunctional nanoparticles for the targeted magnetic separation and enrichment, label-free SERS imaging, and photothermal destruction of multidrug-resistant bacteria.
abstract: Over the last few years, one of the most important and complex problems facing our society is treating infectious diseases caused by multidrug-resistant bacteria (MDRB), by using current market-existing antibiotics. Driven by this need, we report for the first time the development of the multifunctional popcorn-shaped iron magnetic core-gold plasmonic shell nanotechnology-driven approach for targeted magnetic separation and enrichment, label-free surface-enhanced Raman spectroscopy (SERS) detection, and the selective photothermal destruction of MDR Salmonella DT104. Due to the presence of the "lightning-rod effect", the core-shell popcorn-shaped gold-nanoparticle tips provided a huge field of SERS enhancement. The experimental data show that the M3038 antibody-conjugated nanoparticles can be used for targeted separation and SERS imaging of MDR Salmonella DT104. A targeted photothermal-lysis experiment, by using 670 nm light at 1.5 W cm(-2) for 10 min, results in selective and irreparable cellular-damage to MDR Salmonella. We discuss the possible mechanism and operating principle for the targeted separation, label-free SERS imaging, and photothermal destruction of MDRB by using the popcorn-shaped magnetic/plasmonic nanotechnology.
authors.affiliation: Department of Chemistry, Jackson State University, Jackson, MS, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Fan
authors.forename: Dulal
authors.initials: D
authors.lastname: Senapati
authors.forename: Sadia Afrin
authors.initials: SA
authors.lastname: Khan
authors.forename: Anant Kumar
authors.initials: AK
authors.lastname: Singh
authors.forename: Ashton
authors.initials: A
authors.lastname: Hamme
authors.forename: Brian
authors.initials: B
authors.lastname: Yust
authors.forename: Dhiraj
authors.initials: D
authors.lastname: Sardar
authors.forename: Paresh Chandra
authors.initials: PC
authors.lastname: Ray
mesh_terms: D024901:Drug Resistance, Multiple, Bacterial / Q000528:radiation effects*; D006046:Gold / Q000737:chemistry*; D006358:Hot Temperature; D057927:Hydrophobic and Hydrophilic Interactions; D007501:Iron / Q000737:chemistry*; D008027:Light; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D012475:Salmonella / Q000737:chemistry* / Q000187:drug effects*; D013059:Spectrum Analysis, Raman; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D006046:Gold; D007501:Iron