title: Short communication: nuclear JAK3 and its involvement in CD4 activation in HIV-infected patients.
abstract: The subcellular localization of JAK3 was examined by quantitative image analysis. For the first time, JAK3 was found to be located in the nuclei of primary CD4 lymphocytes. A comparable quantity of JAK3 was recovered in CD4 lymphocytes from healthy donors and HIV-infected patients. By contrast, far more phosphorylated JAK3 (pJAK3) was found in the nuclei of CD4 lymphocytes from HIV-infected patients than from healthy donors. The correlation detected between the quantity of pJAK3 in the nuclei of CD4 lymphocytes and the increase in HLA-DR at their surface suggests that pJAK3 may play a role in the deleterious immune activation characterizing HIV-infected patients.
authors.affiliation: Unité d'Immunogénétique Cellulaire, Département Infection et Epidémiologie et Département d'Immunologie, Institut Pasteur, Paris, France. ivanlandires@yahoo.es
authors.forename: Ivan
authors.initials: I
authors.lastname: Landires
authors.forename: Virginia
authors.initials: V
authors.lastname: Núñez-Samudio
authors.forename: Jacques
authors.initials: J
authors.lastname: Thèze
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D002467:Cell Nucleus / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D053616:Janus Kinase 3 / Q000502:physiology*; D008213:Lymphocyte Activation / Q000276:immunology / Q000502:physiology*
chemical_list: C507933:JAK3 protein, human; D053616:Janus Kinase 3