title: Alkyl esters of gallic acid as anticancer agents: a review.
abstract: The current review presents the antitumoral properties of gallic acid and its ester derivatives. Numerous studies have indicated that the alkyl esters are more effective against tumor cell lines than gallic acid, and that this activity is related to their hydrophobic moiety. All related studies have shown that the antitumor activity is interconnected to the induction of apoptosis by different mechanisms and it depends on the cell type. The results presented in this review may help to emphasize that these compounds could be promising as a new alternative for the treatment of cancer, either alone or in combination with other antitumor drugs to potentiate their effects.
authors.affiliation: Curso de Farmácia, Universidade do Oeste de Santa Catarina, Videira, SC 89560-000, Brazil.
authors.forename: Claudriana
authors.initials: C
authors.lastname: Locatelli
authors.forename: Fabíola Branco
authors.initials: FB
authors.lastname: Filippin-Monteiro
authors.forename: Tânia Beatriz
authors.initials: TB
authors.lastname: Creczynski-Pasa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005707:Gallic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004952:Esters; D005707:Gallic Acid