title: An experimental study on the application of radionuclide imaging in repairing bone defects.
abstract: OBJECTIVE
  In order to study the ability of nano-hydroxyapatite artificial bone in repair of large segmental bone defect and to evaluate the value of radionuclide bone imaging in monitoring the bone's repairing in the bone defect.
  
  
  METHODS
  The animal model of bone defect was made on the bilateral radius of 24 (New repaired with HA artificial bone) with 12 rabbits in each group. The ability of bone defect repair was evaluated by using radionuclide bone imaging at 2， 4， 8 and 12 weeks postoperatively.
  
  
  RESULTS
  The counts of regions of interest (ROI) measure and the target to non-target ratios (T/NT) of the two groups indicate that the experimental group stimulated more bone formation than that of the control group. The differences of the bone reconstruction ability were statistically significant （P ＜ 0.05）.
  
  
  CONCLUSIONS
  The nano-HA artificial has good bone conduction, it can be used for the treatment of bone defects. Radionuclide imaging may be an effective and first choice method for the early monitoring of the bone's reconstruction.
authors.affiliation: Department of Sports Medicine, Shenzhen Second People's Hospital , Shenzhen , P.R. China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhu
authors.forename: Daping
authors.initials: D
authors.lastname: Wang
authors.forename: Liangquan
authors.initials: L
authors.lastname: Peng
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhang
authors.forename: Yangkan
authors.initials: Y
authors.lastname: Ou
authors.forename: Wenzhe
authors.initials: W
authors.lastname: Fen
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Yun
authors.initials: Y
authors.lastname: Han
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000175:diagnosis* / Q000628:therapy*; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D017886:Durapatite / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D023421:Models, Animal; D011817:Rabbits; D011877:Radionuclide Imaging; D011884:Radius / Q000000981:diagnostic imaging* / Q000601:surgery; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends
chemical_list: D018786:Bone Substitutes; C509317:nano-hydroxyapatite-collagen; D003094:Collagen; D017886:Durapatite