title: Gastrostomy tube placement by endoscopy versus radiologic methods in patients with ALS: a retrospective study of complications and outcome.
abstract: Gastrostomy tube placement for malnutrition and weight loss stabilization occurs in many patients with ALS. We sought to compare the outcome and complications of gastrostomy tube placement by endoscopic (PEG) and multiple radiologic (RIG) methods in ALS patients. A retrospective analysis was conducted on all ALS patients evaluated at Northwestern University who received gastrostomy tubes between January 2009 and March 2012. One hundred and eight gastrostomy tube attempts were made on a total of 100 different patients. Failed gastrostomy tube placement occurred in 15.7% of PEGs and 1.9% of RIGs. Post-procedure aspiration was recognized after 10.5% PEG and 0 RIG attempts. Multivariate analysis revealed a linear increase in risk of post-procedure aspiration for every increase in ALSFRS swallow score. No statistically significant differences in failure or complications were observed when comparing two different methods of RIG (push-type vs. pull-type). Our findings support gastrostomy tube placement by radiographic methods in ALS patients. Gastrostomy tube placement by RIG was more often successful and less often associated with aspiration. Our findings add to the growing body of literature that argues for early gastrostomy tube placement in young patients with prominent bulbar involvement.
authors.affiliation: Department of Neurology, Division of Neuromuscular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. jallen1@nmff.org
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Allen
authors.forename: Richard
authors.initials: R
authors.lastname: Chen
authors.forename: Senda
authors.initials: S
authors.lastname: Ajroud-Driss
authors.forename: Robert L
authors.initials: RL
authors.lastname: Sufit
authors.forename: Scott
authors.initials: S
authors.lastname: Heller
authors.forename: Teepu
authors.initials: T
authors.lastname: Siddique
authors.forename: Lisa
authors.initials: L
authors.lastname: Wolfe
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000601:surgery*; D016145:Endoscopy, Digestive System / Q000009:adverse effects*; D005260:Female; D005774:Gastrostomy / Q000009:adverse effects* / Q000295:instrumentation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D011859:Radiography; D012189:Retrospective Studies; D016896:Treatment Outcome