title: Neuropsychiatric predictors of conversion to dementia both in patients with amnestic mild cognitive impairment and those with subcortical vascular MCI.
abstract: OBJECTIVE
  The aim of this study was to investigate whether specific neuropsychiatric domains could predict a conversion to dementia in those patients either with amnestic subtype of mild MCI (aMCI) or subcortical vascular MCI (svMCI).
  
  
  METHODS
  At baseline, all subjects underwent neuropsychological tests, Neuropsychiatric Inventory (NPI), and MRI. We compared the baseline NPI scores between converters (CV) and non-converters (NCV) both in the aMCI and svMCI groups.
  
  
  RESULTS
  The mean follow-up duration was 16.74±8.02 months (range: 4.2-43.9). At the second time point, about 30% of aMCI and svMCI patients converted to dementia with 7.5% of aMCI patients exhibiting improvement to normal cognitive state. In female aMCI patients, those who later improved to normal cognition exhibited higher baseline depression scores than the CV group. However, baseline depression scores were higher in the CV group than the NCV group in svMCI patients, and this difference was significant only in males.
  
  
  CONCLUSIONS
  Our results suggest that depression might serve as a predictive marker of conversion to dementia in patients with svMCI, albeit only in males. On the other hand, patients who later improved to normal cognition showed higher scores of depression at baseline in female aMCI patients, suggesting that longer follow-ups are warranted in female patients with aMCI and depression.
authors.affiliation: Department of Neurology, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, Republic of Korea.
authors.forename: Sook Hui
authors.initials: SH
authors.lastname: Kim
authors.forename: Hyun Seok
authors.initials: HS
authors.lastname: Kang
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hui Jin
authors.initials: HJ
authors.lastname: Ryu
authors.forename: Min young
authors.initials: My
authors.lastname: Kim
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
authors.forename: Seol-Heui
authors.initials: SH
authors.lastname: Han
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000523:psychology*; D017028:Caregivers; D002561:Cerebrovascular Disorders / Q000523:psychology*; D060825:Cognitive Dysfunction / Q000523:psychology*; D003627:Data Interpretation, Statistical; D003704:Dementia / Q000523:psychology*; D003863:Depression / Q000150:complications / Q000523:psychology; D018450:Disease Progression; D004522:Educational Status; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D001523:Mental Disorders / Q000209:etiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D012307:Risk Factors; D012737:Sex Factors
keywords: Amnestic mild cognitive impairment; Neuropsychiatric Inventory; Subcortical vascular mild cognitive impairment