title: Lymphoproliferative disorder that resembles heptosplenic lymphoma during maintenance treatment for T-cell acute lymphoblastic leukemia.
abstract: A 6-year-old male presented with a testicular mass, hepatosplenomegaly, and a pleural effusion while undergoing maintenance chemotherapy for treatment of T-cell acute lymphoblastic leukemia (T-ALL). He was subsequently diagnosed with a lymphoproliferative disorder that resembled hepatosplenic lymphoma (HSL). While the extranodal presentation and the protracted yet aggressive clinical course are consistent with HSL, the findings of monosomy 8 and polymorphic cell populations are unique and have not been previously described in this type of lymphoma.
authors.affiliation: Division of Pathology and Laboratory Medicine, Stony Brook University Medical Center, Stony Brook, New York.
authors.forename: Youjun
authors.initials: Y
authors.lastname: Hu
authors.forename: Tahmeena
authors.initials: T
authors.lastname: Ahmed
authors.forename: Ann-Leslie
authors.initials: AL
authors.lastname: Zaslav
authors.forename: Marc
authors.initials: M
authors.lastname: Golightly
authors.forename: Silvia G
authors.initials: SG
authors.lastname: Spitzer
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Raetz
authors.forename: Edward L
authors.initials: EL
authors.lastname: Chan
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D008113:Liver Neoplasms / Q000473:pathology; D008223:Lymphoma / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000473:pathology*; D060046:Maintenance Chemotherapy; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000473:pathology*; D013160:Splenic Neoplasms / Q000473:pathology