title: Fatty acid composition of serum lipids in patients with type 2 diabetes.
abstract: BACKGROUND
  Serum fatty acid content mainly reflects dietary fat intake. It is not known whether alterations of serum fatty acid compositions predict type 2 diabetes risk.
  
  
  METHODS
  We evaluated fatty acid contents in serum of the 76 normal and 98 diabetic adults taking part in a cross sectional study, using a gas chromatography method.
  
  
  RESULTS
  The contents of total saturated (SFAs) and monounsaturated fatty acids (MUFAs) of the diabetic subjects were significantly higher when compared to the controls (p = 0.006, p = 0.02 respectively). Serum linoleic and polyunsaturated fatty acid (PUFAs) contents of subjects with diabetes were significantly lower than the control group (p = 0.02). There was a negative correlation (p = 0.001, r = -0.429) between serum PUFAs contents and cholesterol/HDL-C ratio in the control group, whereas this correlation in people with diabetes was not significant (p = 0.12). The correlation between serum TG (triglyceride) and SFAs contents of the diabetic patients was significantly positive (p = 0.01, r = 0.252). A significant negative correlation (p = 0.001, r = -0.421) was found between PUFA contents and serum TG levels of people with diabetes; however, the same correlation for the control group was not significant (p = 0.56).
  
  
  CONCLUSIONS
  Diabetes incidence was significantly and positively associated with the proportions of serum palmitic, total saturated and monounsaturated fatty acid contents. Our findings with the use of this biomarker suggest that the dietary fat profile, particularly that of saturated and monounsaturated fatty acids, may contribute to the etiology of diabetes. It seems that patients with type 2 diabetes can have good control on lipid parameters with a higher intake of polyunsaturated fatty acids than saturated fatty acids.
authors.affiliation: Biochemistry Department of Medicine Faculty, Tehran University of Medical Sciences, Hemmat Highway, Tehran, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Korani
authors.forename: Mohsen
authors.initials: M
authors.lastname: Firoozrai
authors.forename: Jafar
authors.initials: J
authors.lastname: Maleki
authors.forename: Faranak
authors.initials: F
authors.lastname: Ghahramanpour
authors.forename: Iraj
authors.initials: I
authors.lastname: Heidari
authors.forename: Soudabeh
authors.initials: S
authors.lastname: Fallah
authors.forename: Morteza
authors.initials: M
authors.lastname: Seifi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000032:analysis*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000737:chemistry; D008297:Male; D008875:Middle Aged
chemical_list: D005231:Fatty Acids, Unsaturated; D008055:Lipids