title: Monitoring the toxic effects of Pb, Cd and Cu on hematological parameters of Wistar rats and potential protective role of lipoic acid and glutathione.
abstract: Heavy metal pollution is a serious environmental and health problem. The negative effects of heavy metals that can enter human body can be reduced by the addition of some supplements. In this study, the effects of lead (Pb), cadmium (Cd) and copper (Cu) on the hematological parameters in Wistar rats in the absence and presence of lipoic acid and glutathione were analyzed. Pb, Cd and Cu intoxication significantly affected the hematological parameters of treated animals. The main effects in the case of Pb and Cd intoxication were decreased values of erythrocytes, hemoglobin and hematocrit (up to 30% and 20% for these two metals, respectively) compared with the control group. Cu intoxication caused decrease in hematocrit, thrombocytes, mean cell volume values (c.a. 15%) and slight decrease in the erythrocyte number, while the value of hemoglobin increased (c.a. 7%). The treatment with lipoic acid and glutathione reduced the toxic effects of these metals in all cases.
authors.affiliation: Faculty of Sciences and Mathematics, University of Niš, Niš, Serbia.
authors.forename: Ruzica
authors.initials: R
authors.lastname: Nikolić
authors.affiliation: Faculty of Sciences and Mathematics, University of Niš, Niš, Serbia nenad.krstic84@yahoo.com.
authors.forename: Nenad
authors.initials: N
authors.lastname: Krstić
authors.affiliation: Faculty of Sciences and Mathematics, University of Niš, Niš, Serbia.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Jovanović
authors.affiliation: Medical Faculty, University Niš, Niš, Serbia.
authors.forename: Gordana
authors.initials: G
authors.lastname: Kocić
authors.affiliation: Medical Faculty, University Niš, Niš, Serbia.
authors.forename: Tatjana P
authors.initials: TP
authors.lastname: Cvetković
authors.affiliation: The National Crime Technical Centre, Ministry of Interior of the Republic of Serbia, Belgrade, Serbia.
authors.forename: Nataša
authors.initials: N
authors.lastname: Radosavljević-Stevanović
mesh_terms: D000818:Animals; D001790:Blood Physiological Phenomena / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects; D002104:Cadmium / Q000633:toxicity*; D003300:Copper / Q000633:toxicity*; D004906:Erythrocyte Count; D005260:Female; D005978:Glutathione / Q000627:therapeutic use*; D006400:Hematocrit; D006454:Hemoglobins / Q000187:drug effects; D007854:Lead / Q000633:toxicity*; D019216:Metals, Heavy / Q000633:toxicity; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012989:Soil Pollutants / Q000633:toxicity; D008063:Thioctic Acid / Q000627:therapeutic use*
chemical_list: D006454:Hemoglobins; D019216:Metals, Heavy; D020011:Protective Agents; D012989:Soil Pollutants; D002104:Cadmium; D007854:Lead; D008063:Thioctic Acid; D003300:Copper; D005978:Glutathione
keywords: Lead; cadmium; copper; glutathione; hematological parameters; lipoic acid