title: Combined effects of antenatal receipt of influenza vaccine by mothers and pneumococcal conjugate vaccine receipt by infants: results from a randomized, blinded, controlled trial.
abstract: A 2 × 2 factorial trial was performed to determine the efficacy of antennal influenza vaccination of mothers plus pneumococcal conjugate vaccination of their infants against respiratory illness during early infancy. The efficacy of trivalent inactivated influenza vaccine (TIV; delivered to mothers) plus 7-valent pneumococcal vaccine (PCV7; delivered to infants) was higher than the efficacy of TIV alone or PCV7 alone. During the period of the study in which influenza was circulating, the efficacy of TIV plus PCV7 was 72.4% (95% confidence interval, 30.2%-89.1%) against febrile respiratory illness and 66.4% (95% CI, 14.3%-86.9%) against medically attended acute respiratory illness.
authors.affiliation: Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA. somer@emory.edu
authors.forename: Saad B
authors.initials: SB
authors.lastname: Omer
authors.forename: Khalequ
authors.initials: K
authors.lastname: Zaman
authors.forename: Eliza
authors.initials: E
authors.lastname: Roy
authors.forename: Shams E
authors.initials: SE
authors.lastname: Arifeen
authors.forename: Rubhana
authors.initials: R
authors.lastname: Raqib
authors.forename: Laila
authors.initials: L
authors.lastname: Noory
authors.forename: Katherine
authors.initials: K
authors.lastname: Seib
authors.forename: Robert F
authors.initials: RF
authors.lastname: Breiman
authors.forename: Mark C
authors.initials: MC
authors.lastname: Steinhoff
mesh_terms: D001459:Bangladesh; D016001:Confidence Intervals; D004311:Double-Blind Method; D005260:Female; D018073:Haemophilus Vaccines / Q000627:therapeutic use; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000627:therapeutic use*; D007251:Influenza, Human / Q000517:prevention & control; D011008:Pneumococcal Infections / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012141:Respiratory Tract Infections / Q000382:microbiology / Q000517:prevention & control* / Q000821:virology; D012621:Seasons; D016896:Treatment Outcome; D014611:Vaccination
chemical_list: C414006:23-valent pneumococcal capsular polysaccharide vaccine; D018073:Haemophilus Vaccines; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D007252:Influenza Vaccines; D022242:Pneumococcal Vaccines