title: Pitfalls of drug development: lessons learned from trials of denufosol in cystic fibrosis.
authors.affiliation: Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. rmoss@stanford.edu
authors.forename: Richard B
authors.initials: RB
authors.lastname: Moss
mesh_terms: D000293:Adolescent; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003550:Cystic Fibrosis / Q000188:drug therapy*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism; D003845:Deoxycytosine Nucleotides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D018450:Disease Progression; D015195:Drug Design; D004345:Drug Industry; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D012107:Research Design; D013183:Sputum / Q000378:metabolism; D013997:Time Factors; D016896:Treatment Outcome; D014529:Uridine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: C505032:CFTR protein, human; D003845:Deoxycytosine Nucleotides; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; C465279:denufosol tetrasodium; D014529:Uridine