title: Prolinethiol ether catalysis in an asymmetric Michael reaction: solvent-free synthesis of functionalized monohaloalkenes.
abstract: The organocatalytic Michael reaction of ketones with γ-monohalonitrodienes catalyzed by chiral prolinethiol ether under solvent-free conditions was developed. The described method represents a novel approach for accessing highly functionalized monohaloalkenes with α, β-stereocenters of up to >99% ee.
authors.affiliation: State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
authors.forename: Ai-Bao
authors.initials: AB
authors.lastname: Xia
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
authors.forename: Dan-Qian
authors.initials: DQ
authors.lastname: Xu
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Du
authors.forename: Zhao-Bo
authors.initials: ZB
authors.lastname: Li
authors.forename: Zhen-Yuan
authors.initials: ZY
authors.lastname: Xu
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D004986:Ether / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D006846:Hydrocarbons, Halogenated; D012997:Solvents; D013438:Sulfhydryl Compounds; D004986:Ether; D011392:Proline