title: Current role of CT and whole body MRI in multiple myeloma.
abstract: Radiology of bone lacunae can help differentiate between smouldering and symptomatic myeloma. CT seems to be more apt for this purpose than a standard X-ray but appropriate principles must be applied when performing and reading it. Lesions visible in an MRI above all allow myelomas to be monitored during treatment. Because of the radiation dose, whole body CT must be performed with a slice thickness of 2mm, increments of 1.5 and intensity of 40mAs. It should be read associating the reading of the axial slices with reading the mean coronal and sagittal projections of a thickness of 2cm. Whole body MRI must associate T1-weighted sagittal, STIR coronal and b-800 diffusion-weighted axial sequences. Changes in the disease correlate with changes in the diffusion, STIR and T1-weighted images interpreted together. While whole body CT has a place in clinical routine, the indication for whole body MRI still needs to be clarified and has yet to take its place in research protocols.
authors.affiliation: Radiology and Medical Imaging Department, Rennes University Hospitals, Hôpital Sud, BP 90347, 35203 Rennes cedex 2, France. Electronic address: regis.duvauferrier@chu-rennes.fr.
authors.forename: R
authors.initials: R
authors.lastname: Duvauferrier
authors.affiliation: Internal Medicine Department, Rennes University Hospitals, Hôpital Sud, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: M
authors.initials: M
authors.lastname: Valence
authors.affiliation: Internal Medicine Department, Rennes University Hospitals, Hôpital Sud, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: S
authors.initials: S
authors.lastname: Patrat-Delon
authors.affiliation: Radiology and Medical Imaging Department, Rennes University Hospitals, Hôpital Sud, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: E
authors.initials: E
authors.lastname: Brillet
authors.affiliation: Radiology and Medical Imaging Department, Rennes University Hospitals, Hôpital Sud, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: E
authors.initials: E
authors.lastname: Niederberger
authors.affiliation: Radiology and Medical Imaging Department, Rennes University Hospitals, Hôpital Sud, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: A
authors.initials: A
authors.lastname: Marchand
authors.affiliation: Radiology and Medical Imaging Department, Rennes University Hospitals, Hôpital Sud, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: M
authors.initials: M
authors.lastname: Rescan
authors.affiliation: Radiology and Medical Imaging Department, Rennes University Hospitals, Hôpital Sud, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: R
authors.initials: R
authors.lastname: Guillin
authors.affiliation: Internal Medicine Department, Rennes University Hospitals, Hôpital Sud, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: O
authors.initials: O
authors.lastname: Decaux
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000175:diagnosis; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D049268:Positron-Emission Tomography; D011829:Radiation Dosage; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
chemical_list: D019788:Fluorodeoxyglucose F18