title: Underdiagnosis of chikungunya virus infections in symptomatic dutch travelers returning from the Indian ocean area.
abstract: A putative underdiagnosis of clinical chikungunya virus infection in Dutch travelers to the Indian Ocean area was addressed by retrospective screening of all sera for which requested dengue virus serology was negative in the period 2007 to 2010. Evidence for a recent infection was observed in 6.5% of 107 patients, indicating a substantial underdiagnosis and the need for increased awareness among physicians.
authors.affiliation: Netherlands Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. Chantal.Reusken@RIVM.nl
authors.forename: Chantal B E M
authors.initials: CB
authors.lastname: Reusken
authors.forename: Jacinta
authors.initials: J
authors.lastname: Bakker
authors.forename: Johan H J
authors.initials: JH
authors.lastname: Reimerink
authors.forename: Hana
authors.initials: H
authors.lastname: Zelena
authors.forename: Marion G P
authors.initials: MG
authors.lastname: Koopmans
mesh_terms: D018354:Alphavirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D065632:Chikungunya Fever; D002646:Chikungunya virus / Q000302:isolation & purification*; D003716:Dengue Virus / Q000302:isolation & purification*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D006801:Humans; D019156:Indian Ocean / Q000453:epidemiology; D009426:Netherlands / Q000453:epidemiology; D012189:Retrospective Studies; D012698:Serologic Tests / Q000379:methods*; D019595:Severe Dengue / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D014195:Travel / Q000706:statistics & numerical data