title: Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones.
abstract: The discovery and development of essential drugs for Chagas disease is a major concern worldwide. New substituted 1,4-naphthoquinones were synthesized and tested against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. These products exhibited substantial activity against T. cruzi, especially 2-((8E,11Z)-heptadeca-8,11-dienyl)-3-hydroxynaphthalene-1,4-dione (9) with IC(50) of 7.8 μM.
authors.affiliation: Chemistry Sector (LP4), Center of Exact Sciences and Technology, Federal University of Mato Grosso do Sul, 79070-900 Campo Grande, MS, Brazil.
authors.forename: Adriano
authors.initials: A
authors.lastname: Olímpio da Silva
authors.forename: Rosangela
authors.initials: R
authors.lastname: da Silva Lopes
authors.forename: Ricardo
authors.initials: R
authors.lastname: Vieira de Lima
authors.forename: Camila
authors.initials: C
authors.lastname: Santos Suniga Tozatti
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Marques
authors.forename: Sérgio
authors.initials: S
authors.lastname: de Albuquerque
authors.forename: Adilson
authors.initials: A
authors.lastname: Beatriz
authors.forename: Dênis
authors.initials: D
authors.lastname: Pires de Lima
mesh_terms: D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D009285:Naphthoquinones; C035342:1,4-naphthoquinone