title: The fibromyalgia family study: a genome-wide linkage scan study.
abstract: OBJECTIVE
  Familial aggregation of fibromyalgia has been increasingly recognized. The goal of this study was to conduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia.
  
  
  METHODS
  We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman-Elston regression approach.
  
  
  RESULTS
  The estimated sibling recurrence risk ratio (λs ) for fibromyalgia was 13.6 (95% confidence interval 10.0-18.5), based on a reported population prevalence of 2%. Genome-wide suggestive evidence of linkage was observed at markers D17S2196 (empirical P [Pe ]=0.00030) and D17S1294 (Pe=0.00035) on chromosome 17p11.2-q11.2.
  
  
  CONCLUSIONS
  The estimated sibling recurrence risk ratio (λs ) observed in this study suggests a strong genetic component of fibromyalgia. This is the first report of genome-wide suggestive linkage of fibromyalgia to the chromosome 17p11.2-q11.2 region. Further investigation of these multicase families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia.
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio 44106, USA. Lesley.Arnold@uc.edu
authors.forename: Lesley M
authors.initials: LM
authors.lastname: Arnold
authors.forename: Jinbo
authors.initials: J
authors.lastname: Fan
authors.forename: I Jon
authors.initials: IJ
authors.lastname: Russell
authors.forename: Muhammad B
authors.initials: MB
authors.lastname: Yunus
authors.forename: Muhammad Asim
authors.initials: MA
authors.lastname: Khan
authors.forename: Irving
authors.initials: I
authors.lastname: Kushner
authors.forename: Jane M
authors.initials: JM
authors.lastname: Olson
authors.forename: Sudha K
authors.initials: SK
authors.lastname: Iyengar
mesh_terms: D000328:Adult; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005260:Female; D005356:Fibromyalgia / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D010641:Phenotype; D035781:Siblings