title: The effect of a physiological concentration of caffeine on the endurance of maximally and submaximally stimulated mouse soleus muscle.
abstract: The use of caffeine as an ergogenic aid to promote endurance has been widely studied, with human literature showing the greatest benefit during submaximal muscle activities. Recent evidence suggests that the acute treatment of skeletal muscle with physiological concentrations of caffeine (70 μM maximum) will directly potentiate force production. The aims of the present study are: firstly, to assess the effects of a physiological concentration (70 μM) of caffeine on endurance in maximally activated mouse soleus (relatively slow) muscle; and secondly, to examine whether endurance changes when muscle is activated submaximally during caffeine treatment. Maximally stimulated soleus muscle treated with 70 μM caffeine resulted in a significant (17.6 %) decrease in endurance. In contrast, at a submaximal stimulation frequency, caffeine treatment significantly prolonged endurance (by 19.2 %). Findings are activation-dependent such that, during high frequency stimulation, caffeine accelerates fatigue, whereas, during low frequency stimulation, caffeine delays fatigue.
authors.affiliation: Faculty of Health and Life Sciences, James Starley Building, Coventry University, Priory Street, Coventry CV1 5FB, UK. tallisj2@uni.coventry.ac.uk
authors.forename: Jason
authors.initials: J
authors.lastname: Tallis
authors.forename: Rob S
authors.initials: RS
authors.lastname: James
authors.forename: Val M
authors.initials: VM
authors.lastname: Cox
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Duncan
mesh_terms: D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D007537:Isometric Contraction / Q000187:drug effects*; D051379:Mice; D018763:Muscle Fatigue / Q000187:drug effects; D053580:Muscle Strength / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D010807:Physical Endurance / Q000187:drug effects*; D020127:Recovery of Function; D013997:Time Factors
chemical_list: D002110:Caffeine