title: Small-molecule lipid-bilayer anion transporters for biological applications.
abstract: The development of small-molecule lipid-bilayer anion transporters for potential future use in channel replacement therapy for the treatment of diseases caused by dysregulation of anion transport (such as cystic fibrosis), and in treating cancer by perturbing chemical gradients within cells, thus triggering apoptosis, is an area of intense current interest. This Minireview looks at recent developments in the design of small-molecule transmembrane anion transporters and focuses on the progress so far in employing these compounds in biological systems.
authors.affiliation: Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Busschaert
authors.forename: Philip A
authors.initials: PA
authors.lastname: Gale
mesh_terms: D000838:Anions / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D003550:Cystic Fibrosis / Q000188:drug therapy; D006801:Humans; D017136:Ion Transport; D008051:Lipid Bilayers / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D011353:Prodigiosin / Q000031:analogs & derivatives / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D000838:Anions; D000970:Antineoplastic Agents; D008051:Lipid Bilayers; D011353:Prodigiosin