title: Inhibition of HIV-1 replication by a tricyclic coumarin GUT-70 in acutely and chronically infected cells.
abstract: The anti-HIV-1 activity of GUT-70, a natural product derived from the stem bark of Chlophyllum brasiliense, was evaluated. GUT-70 inhibited HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB. Our results strengthen the idea that NF-κB pathway is one of the potential targets to control HIV-1 replication and that GUT-70 could serve as a lead compound to develop novel therapeutic agents against HIV-1 infection.
authors.affiliation: Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Kudo
authors.forename: Manabu
authors.initials: M
authors.lastname: Taura
authors.forename: Kouki
authors.initials: K
authors.lastname: Matsuda
authors.forename: Masako
authors.initials: M
authors.lastname: Shimamoto
authors.forename: Ryusho
authors.initials: R
authors.lastname: Kariya
authors.forename: Hiroki
authors.initials: H
authors.lastname: Goto
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Hattori
authors.forename: Shinya
authors.initials: S
authors.lastname: Kimura
authors.forename: Seiji
authors.initials: S
authors.lastname: Okada
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D014779:Virus Replication / Q000187:drug effects*; D000097782:NF-kappaB-Inducing Kinase
chemical_list: D000998:Antiviral Agents; D003374:Coumarins; D017346:Protein Serine-Threonine Kinases; D000097782:NF-kappaB-Inducing Kinase; C493688:GUT-70