title: Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms.
abstract: This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc (CD) platform. This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date. The implicit assumptions and limitations of these models are discussed. The fluid meniscus dynamics before bursting is broken up into a multi-stage model and a more accurate version of the burst frequency equation for the capillary valves is proposed. The modified equations are used to evaluate the effects of various CD design parameters such as the hydraulic diameter, the height to width aspect ratio, and the opening wedge angle of the channel on the burst pressure.
authors.affiliation: Medical Informatics and Biological Micro-electro-mechanical Systems (MIMEMS) Specialized Laboratory, Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Tzer Hwai Gilbert
authors.initials: TH
authors.lastname: Thio
authors.forename: Salar
authors.initials: S
authors.lastname: Soroori
authors.forename: Fatimah
authors.initials: F
authors.lastname: Ibrahim
authors.forename: Wisam
authors.initials: W
authors.lastname: Al-Faqheri
authors.forename: Norhayati
authors.initials: N
authors.lastname: Soin
authors.forename: Lawrence
authors.initials: L
authors.lastname: Kulinsky
authors.forename: Marc
authors.initials: M
authors.lastname: Madou
mesh_terms: D000465:Algorithms; D002498:Centrifugation / Q000295:instrumentation; D016250:Compact Disks; D004867:Equipment Design; D057446:Hydrodynamics; D044085:Microfluidics / Q000295:instrumentation*; D008904:Miniaturization; D008962:Models, Theoretical