title: Renal vasculitis in 2012: reclassification and the introduction of biologicals.
abstract: 2012 saw the classification of the systemic vasculitides revised. Genetic studies showed that granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are different diseases with aberrant immune responses to different autoantigens. B-cell depletion with rituximab also acquired a primary role in the treatment of GPA and MPA, as well as in cryoglobulinaemic vasculitis.
authors.affiliation: Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. c.g.m.kallenberg@umcg.nl
authors.forename: Cees G M
authors.initials: CG
authors.lastname: Kallenberg
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D001691:Biological Therapy / Q000639:trends*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007674:Kidney Diseases / Q000145:classification / Q000188:drug therapy / Q000276:immunology; D055953:Microscopic Polyangiitis / Q000145:classification / Q000188:drug therapy / Q000276:immunology; D000069283:Rituximab; D056647:Systemic Vasculitis / Q000145:classification / Q000188:drug therapy / Q000276:immunology
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab