title: Risk assessment of clinical reactions to legumes in peanut-allergic children.
abstract: Peanut-allergic children might be at risk for reactions to other legumes. However, it is not always possible to perform multiple oral food challenges in children. On the basis of patient case history, in vitro diagnostic tests, and eventually food challenges, we aimed at developing an algorithm for risk assessment of possible clinical reactions to other legumes (soybean, lupine, fresh, and blanched green pea). Seventy-five consecutive patients with a positive oral food challenge to peanut were included in the study. All tests were run as part of the routine allergy examination. A high proportion of patients and/or caretakers refused the administered legume oral food challenges. Obtained diagnoses from histamine release did not correlate significantly to the outcome of the algorithm. Interestingly, threshold from peanut challenges did not correlate with the risk assessment.The algorithm presented in this study can be used when advising peanut-allergic children and their caretakers about what other legumes to avoid in the diet.
authors.affiliation: From the *Department of Agricultural Sciences, Faculty of Life Sciences, University of Copenhagen, Copenhagen; ∥Laboratory of Medical Allergology, Allergy Clinic, National University Hospital, Copenhagen; ‡Allergy Centre, Odense University Hospital, Odense; and §RefLab ApS, National University Hospital, Copenhagen, Denmark.
authors.forename: Louise Bjerremann
authors.initials: LB
authors.lastname: Jensen
authors.forename: Milene
authors.initials: M
authors.lastname: Andersen
authors.forename: Per Stahl
authors.initials: PS
authors.lastname: Skov
authors.forename: Lars K
authors.initials: LK
authors.lastname: Poulsen
authors.forename: Carsten
authors.initials: C
authors.lastname: Bindslev-Jensen