title: A model of smart G-quadruplex ligand.
abstract: An unprecedented strategy to control the quadruplex- vs duplex-DNA selectivity of a ligand is reported. We designed a compound whose structure can rearrange when it interacts with a G-quadruplex, thereby controlling its affinity. Thus, the first "smart G-quadruplex ligand" is reported, since this ligand experiences a structural change in the presence of quadruplexes but not in the presence of duplexes, ensuring a high level of quadruplex selectivity.
authors.affiliation: Institut de Chimie Moléculaire de l' Université de Bourgogne, CNRS UMR6302, 9, Avenue Alain Savary, 21000 Dijon, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Haudecoeur
authors.forename: Loic
authors.initials: L
authors.lastname: Stefan
authors.forename: Franck
authors.initials: F
authors.lastname: Denat
authors.forename: David
authors.initials: D
authors.lastname: Monchaud
mesh_terms: D004305:Dose-Response Relationship, Drug; D054856:G-Quadruplexes; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D054852:Small Molecule Libraries
chemical_list: D008024:Ligands; D054852:Small Molecule Libraries