title: [Formation of autoimmune reactions in patients with combined course of chronic obstructive pulmonary disease and chronic pancreatitis].
abstract: The article highlights some pathogenetic mechanisms of autoimmune reactions in patients with chronic obstructive pulmonary disease (COPD) and chronic pancreatitis. It is proved that the presence of concomitant chronic pancreatitis exacerbates the syndrome of endogenous intoxication and accompanied by development of phagocytic cells decompensation, which leads to disruption of regulatory mechanisms of both cellular and humoral immune responses. This fact allows us to consider the presence of concomitant chronic pancreatitis in patients with COPD as a prognostically unfavorable factor.
authors.affiliation: Kharkov State Medical University, Ukraine.
authors.forename: N
authors.initials: N
authors.lastname: Zhelezniakova
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology*; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D050500:Pancreatitis, Chronic / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D010586:Phagocytes / Q000276:immunology; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology