title: Contributions of aminoacyl-tRNA synthetase-interacting multifunctional protein-3 to mammalian translation initiation.
abstract: Aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) stabilizes and protects mammalian methionyl-tRNA synthetase (MRS) and eukaryotic initiation factor 2 subunit gamma (eIF2γ), factors involved in the formation and the delivery of Met-tRNA(i)Met respectively, through the binding interactions. Due to the protections that MRS and eIF2γ are provided from the interactions with AIMP3, cellular levels of MRS and eIF2γ may be able to be maintained high enough for their canonical and/or non-canonical functions.
authors.affiliation: Department of Life Science, Gachon University, San 65, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, 461-701, Kyeonggi-Do, Korea.
authors.forename: Min Jeong
authors.initials: MJ
authors.lastname: Ku
authors.forename: Sang Yeol
authors.initials: SY
authors.lastname: Lee
mesh_terms: D002460:Cell Line; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008718:Methionine-tRNA Ligase / Q000235:genetics / Q000378:metabolism; D010442:Peptide Chain Initiation, Translational; D010445:Peptide Elongation Factors / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D012358:RNA, Transfer, Met / Q000235:genetics / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C529799:EEF1E1 protein, human; D015852:Eukaryotic Initiation Factor-2; D010445:Peptide Elongation Factors; D012358:RNA, Transfer, Met; D025521:Tumor Suppressor Proteins; D008718:Methionine-tRNA Ligase