title: Guide-star-based computational adaptive optics for broadband interferometric tomography.
abstract: We present a method for the numerical correction of optical aberrations based on indirect sensing of the scattered wavefront from point-like scatterers ("guide stars") within a three-dimensional broadband interferometric tomogram. This method enables the correction of high-order monochromatic and chromatic aberrations utilizing guide stars that are revealed after numerical compensation of defocus and low-order aberrations of the optical system. Guide-star-based aberration correction in a silicone phantom with sparse sub-resolution-sized scatterers demonstrates improvement of resolution and signal-to-noise ratio over a large isotome. Results in highly scattering muscle tissue showed improved resolution of fine structure over an extended volume. Guide-star-based computational adaptive optics expands upon the use of image metrics for numerically optimizing the aberration correction in broadband interferometric tomography, and is analogous to phase-conjugation and time-reversal methods for focusing in turbid media.
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Adie
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Shemonski
authors.forename: Benedikt W
authors.initials: BW
authors.lastname: Graf
authors.forename: Adeel
authors.initials: A
authors.lastname: Ahmad
authors.forename: P
authors.initials: P
authors.lastname: Scott Carney
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Boppart