title: Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality.
abstract: BACKGROUND
  To update and refine systematic literature review on the association between outpatient statins use and mortality in patients with infectious disease.
  
  
  METHODS
  We searched articles published before September 31, 2012, on the association between statins and infectious disease-related mortality through electronic databases. Eligible articles were analyzed in Review Manager 5.1. We conducted stratification analysis by study design, infection types, clinical outcomes and study locations.
  
  
  RESULTS
  The pooled odds ratio (OR) for death (statins use vs. no use) across the 41 included studies was 0.71 (95% confidence interval: 0.64, 0.78). The corresponding pooled ORs were 0.58 (0.38, 0.90), 0.66 (0.57, 0.75), 0.71 (0.57, 0.89) and 0.83 (0.67, 1.04) for the case-control study, retrospective cohort studies, prospective cohort studies and RCTs; 0.40 (0.20, 0.78), 0.61 (0.41, 0.90), 0.69 (0.62, 0.78) and 0.86 (0.68, 1.09) for bacteremia, sepsis, pneumonia and other infections; 0.62 (0.534, 0.72), 0.68 (0.53, 0.89), 0.71 (0.61, 0.83) and 0.86 (0.70, 1.07) for 30-day, 90-day, in-hospital and long-term (>1 year) mortality, respectively.
  
  
  CONCLUSIONS
  Outpatient statins use is associated with a lower risk of death in patients with infectious disease in observational studies, but in a less extent in clinical trials. This association also varies considerably by infection types and clinical outcomes.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Key Laboratory of Tropical Diseases Control Research, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong Province, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ma
authors.forename: Xiaozhong
authors.initials: X
authors.lastname: Wen
authors.forename: Jing
authors.initials: J
authors.lastname: Peng
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Guo
authors.forename: Jiahai
authors.initials: J
authors.lastname: Lu
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007239:Infections / Q000188:drug therapy / Q000401:mortality*; D012196:Review Literature as Topic; D015996:Survival Rate
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors