title: Synthetic studies on CP-225,917 and CP-263,114: access to advanced tetracyclic systems by intramolecular conjugate displacement and [2,3]-Wittig rearrangement.
abstract: An advanced intermediate related to the structures of CP-225,917 and CP-263,114 was constructed by a sequence based on the use of Grob-like fragmentation, intramolecular conjugate displacement, and [2,3]-Wittig rearrangement. A variant of the [2,3]-Wittig rearrangement was developed.
authors.affiliation: Chemistry Department, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
authors.forename: Farzad
authors.initials: F
authors.lastname: Malihi
authors.forename: Derrick L J
authors.initials: DL
authors.lastname: Clive
authors.forename: Che-Chien
authors.initials: CC
authors.lastname: Chang
authors.lastname: Minaruzzaman
mesh_terms: D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008299:Maleic Anhydrides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C104959:CP 225917; C104957:CP 263114; D006576:Heterocyclic Compounds, 4 or More Rings; D008299:Maleic Anhydrides