title: Marked toxicity of Albizia bernieri extracts on embryo-larval development in the medaka fish (Oryzias latipes).
abstract: Previous phytochemical studies have shown that the plants of the Albizia genus (Fabaceae) contain bioactive saponins, lignans, spermine alkaloids, flavonoids, glycosides phenols and pyridoxine derivatives. Their extracts sometimes display medical properties, but can have also toxic effects. The purpose of our study was to determine the in vivo toxicity of Albizia bernieri seeds in the experimental model of the medaka fish embryo, which is recommended for use in toxicity studies. Our results show clearly that incubating the embryos or larvae of the medaka fish in a medium containing A. bernieri extracts caused a dose-dependent reduction in embryo or larvae survival. Embryos exposed to an extract of A. bernieri displayed cerebral lesions, such as cell lysis and the emergence of lysosomes in the glial tissue. We conclude that when comparing with data obtained with different plant extracts tested on medaka development in our laboratory, A. bernieri displays an unusually high toxicity. Focussing on the cerebral target as well as the fish behaviour could bring more specific informations.
authors.affiliation: UMR 7245 CNRS-MNHN Molécules de Communication et Adaptation des Micro-organismes, Muséum National d'Histoire Naturelle, 12 rue Buffon, F-75231 Paris Cedex 05, France.
authors.forename: Lovarintsoa
authors.initials: L
authors.lastname: Randriamampianina
authors.forename: Anne
authors.initials: A
authors.lastname: Offroy
authors.forename: Lengo
authors.initials: L
authors.lastname: Mambu
authors.forename: Ranjana
authors.initials: R
authors.lastname: Randrianarivo
authors.forename: Danielle
authors.initials: D
authors.lastname: Rakoto
authors.forename: Victor
authors.initials: V
authors.lastname: Jeannoda
authors.forename: Chakib
authors.initials: C
authors.lastname: Djediat
authors.forename: Simone
authors.initials: S
authors.lastname: Puiseux Dao
authors.forename: Marc
authors.initials: M
authors.lastname: Edery
mesh_terms: D031289:Albizzia / Q000737:chemistry*; D000818:Animals; D054022:Cerebrum / Q000187:drug effects / Q000196:embryology / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D020964:Embryo Loss / Q000139:chemically induced; D004625:Embryo, Nonmammalian / Q000187:drug effects* / Q000196:embryology; D005260:Female; D007814:Larva / Q000187:drug effects* / Q000254:growth & development; D009990:Oryzias / Q000502:physiology*; D010936:Plant Extracts / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D010936:Plant Extracts