title: A polymer-(tandem drugs) conjugate for enhanced cancer treatment.
abstract: A novel strategy for combination chemotherapy (platinum and demethylcantharidin) via a polymer-(tandem drugs) conjugate for enhanced cancer treatment is demonstrated. Cisplatin can be released inside cell by reduction to attack DNA, while DMC will be hydrolyzed subsequently to block DNA-damage-induced defense mechanisms by serine/threonine phosphatase PP2A inhibition. Synergistic effect of the polymer-(tandem drugs) conjugate causes complete suppression of H22 liver tumor xenografts without recurrence.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
authors.forename: Dongfang
authors.initials: D
authors.lastname: Zhou
authors.forename: Haihua
authors.initials: H
authors.lastname: Xiao
authors.forename: Fanbo
authors.initials: F
authors.lastname: Meng
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Li
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Li
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
authors.forename: Yubin
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000737:chemistry*; D002193:Cantharidin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D045744:Cell Line, Tumor; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D051379:Mice; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry*; D010984:Platinum / Q000008:administration & dosage* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D053769:Nanocapsules; D011108:Polymers; C464435:demethylcantharidin; D010984:Platinum; D002193:Cantharidin