title: Synthesis of imidazo[1,2-a]pyridines: "water-mediated" hydroamination and silver-catalyzed aminooxygenation.
abstract: Aqueous syntheses of methylimidazo[1,2-a]pyridines without any deliberate addition of catalyst are reported. Imidazo[1,2-a]pyrazine and imidazo[2,1-a]isoquinoline were also obtained in good yields under similar conditions. With acetonitrile as solvent, Ag-catalyzed intramolecular aminooxygenation produced imidazo[1,2-a]pyridine-3-carbaldehydes in moderate to good yields.
authors.affiliation: Central Salt & Marine Chemicals Research Institute, Council of Scientific & Industrial Research, G.B. Marg, Bhavnagar-364 002, Gujarat, India.
authors.forename: Darapaneni
authors.initials: D
authors.lastname: Chandra Mohan
authors.forename: Sadu
authors.initials: S
authors.lastname: Nageswara Rao
authors.forename: Subbarayappa
authors.initials: S
authors.lastname: Adimurthy
mesh_terms: D002384:Catalysis; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014867:Water
chemical_list: D007093:Imidazoles; D007546:Isoquinolines; D011719:Pyrazines; D011725:Pyridines; C556838:imidazo(1,2-a)pyrazine; C582691:imidazo(2,1-a)isoquinoline; D014867:Water; D012834:Silver