title: Yeast cell wall supplementation alters aspects of the physiological and acute phase responses of crossbred heifers to an endotoxin challenge.
abstract: A study was conducted to determine the effect of feeding yeast cell wall (YCW) products on the physiological and acute phase responses of crossbred, newly-received feedlot heifers to an endotoxin challenge. Heifers (n = 24; 219 ± 2.4 kg) were separated into treatment groups receiving either a control diet (n = 8), YCW-A (2.5 g/heifer/d; n = 8) or YCW-C (2.5 g/heifer/d; n = 8) and were fed for 52 d. On d 37 heifers were challenged i.v. with LPS (0.5 µg/kg body mass) and blood samples were collected from -2 h to 8 h and again at 24 h relative to LPS challenge. There was an increase in vaginal temperature in all heifers post-LPS, with YCW-C maintaining a lower vaginal temperature post-LPS than control and YCW-A heifers. Sickness behavior scores increased post-LPS in all heifers, but were not affected by treatment. Cortisol concentrations were greatest in control heifers post-LPS compared with YCW-A or YCW-C heifers. Concentrations of IFN-γ and TNF-α increased post-LPS, but were not affected by treatment. Serum IL-6 concentrations increased post-LPS and were greater in control heifers than YCW-A and YCW-C heifers. These data indicate that YCW supplementation can decrease the physiological and acute phase responses of newly-received heifers following an endotoxin challenge.
authors.affiliation: USDA-ARS Livestock Issues Research Unit, Lubbock, TX 79403, USA
authors.forename: Nicole C
authors.initials: NC
authors.lastname: Burdick Sanchez
authors.forename: Tanner R
authors.initials: TR
authors.lastname: Young
authors.forename: Jeffery A
authors.initials: JA
authors.lastname: Carroll
authors.forename: Jimmie R
authors.initials: JR
authors.lastname: Corley
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Rathmann
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Johnson
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology* / Q000517:prevention & control; D061605:Administration, Intravenous; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001947:Breeding; D002417:Cattle; D002473:Cell Wall / Q000276:immunology*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D019587:Dietary Supplements; D004731:Endotoxins / Q000276:immunology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006854:Hydrocortisone / Q000097:blood; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000276:immunology*; D012441:Saccharomyces cerevisiae / Q000276:immunology*
chemical_list: D016207:Cytokines; D004731:Endotoxins; D015850:Interleukin-6; D008070:Lipopolysaccharides; D006854:Hydrocortisone
keywords: Acute phase response; LPS; cattle; cortisol; cytokines; yeast cell wall