title: [Association of polymorphic markers of CASP8, BCL2 and BAX genes with aging and longevity].
abstract: We performed the analysis of genotype frequency dynamics of CASP8, BCL2 and BAX genes polymorphic markers between 21 and 109 years in the group of Ethnic Tatars from Bashkortostan. Genotyping was carried out using PCR and PCR-RFLP. We found associations between age and -652(6N)I/D polymorphism of CASP8 gene (rs3834129), 140016C>T polymorphism of BCL2 gene (rs12454712) and 919A>G polymorphism of BAX gene (rs1805419). An increase of genotype frequency of BCL2*C/*C and decrease of genotype frequency of CASP8*I/*D was observed in male of senile age; and also decrease of genotype frequency of BAX*G/*G among long-livers. In female of longevity age, the number of CASP8*I/*D, BCL2*T/*T and BAX*A/*A genotype carriers was higher and number of CASP8*DI/*D, BCL2*C/*C, BAX*A/*G and BAX *G/*G genotype carriers was reduced.
authors.forename: V V
authors.initials: VV
authors.lastname: Erdman
authors.forename: T R
authors.initials: TR
authors.lastname: Nasibullin
authors.forename: I A
authors.initials: IA
authors.lastname: Tuktarova
authors.forename: O E
authors.initials: OE
authors.lastname: Mustafina
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D000483:Alleles; D001486:Bashkiria; D053181:Caspase 8 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D019254:Genes, bcl-2 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D055815:Young Adult; D051028:bcl-2-Associated X Protein / Q000235:genetics*
chemical_list: D051028:bcl-2-Associated X Protein; C505530:CASP8 protein, human; D053181:Caspase 8