title: Peripheral administration of D-cycloserine rescues memory consolidation following bacterial endotoxin exposure.
abstract: In the current study, the partial NMDA receptor agonist D-cycloserine (DCS) rescued memory consolidation following systemic bacterial endotoxin exposure. DCS failed, however, to restore hippocampal BDNF mRNA levels that were diminished following a systemic administration of LPS, and did not alter NR1 or NR2C NMDA receptor subunit expression. These results extend prior research into the role of DCS in neural-immune interactions, and indicate that the detrimental effects of peripheral LPS administration on consolidation of contextual fear memory may be ameliorated with DCS treatment, though the mechanisms underlying these effects are currently unclear.
authors.affiliation: Department of Psychology, Texas Christian University, Fort Worth, TX 76129, USA.
authors.forename: Dinko
authors.initials: D
authors.lastname: Kranjac
authors.forename: Kyle M
authors.initials: KM
authors.lastname: Koster
authors.forename: Marielle S
authors.initials: MS
authors.lastname: Kahn
authors.forename: Micah J
authors.initials: MJ
authors.lastname: Eimerbrink
authors.forename: Brent M
authors.initials: BM
authors.lastname: Womble
authors.forename: Brenton G
authors.initials: BG
authors.lastname: Cooper
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Chumley
authors.forename: Gary W
authors.initials: GW
authors.lastname: Boehm
mesh_terms: D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D003523:Cycloserine / Q000494:pharmacology / Q000627:therapeutic use*; D004926:Escherichia coli / Q000187:drug effects; D005239:Fear / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009483:Neuropsychological Tests; D012333:RNA, Messenger / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000096:biosynthesis
chemical_list: D000963:Antimetabolites; D008070:Lipopolysaccharides; C409466:NR1 NMDA receptor; C432823:NR2C NMDA receptor; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D003523:Cycloserine