title: Hemodynamic assessment of pre- and post-operative aortic coarctation from MRI.
abstract: Coarctation of the aorta (CoA), is a congenital defect characterized by a severe narrowing of the aorta, usually distal to the aortic arch. The treatment options include surgical repair, stent implantation, and balloon angioplasty. In order to evaluate the physiological significance of the pre-operative coarctation and to assess the post-operative results, the hemodynamic analysis is usually performed by measuring the pressure gradient (deltaP) across the coarctation site via invasive cardiac catheterization. The measure of success is reduction of the (deltaP > 20 mmHg) systolic blood pressure gradient. In this paper, we propose a non-invasive method based on Computational Fluid Dynamics and MR imaging to estimate the pre- and post-operative hemodynamics for both native and recurrent coarctation patients. High correlation of our results and catheter measurements is shown on corresponding pre- and post-operative examination of 5 CoA patients.
authors.affiliation: Technical University of Munich, Germany.
authors.forename: Kristóf
authors.initials: K
authors.lastname: Ralovich
authors.forename: Lucian
authors.initials: L
authors.lastname: Itu
authors.forename: Viorel
authors.initials: V
authors.lastname: Mihalef
authors.forename: Puneet
authors.initials: P
authors.lastname: Sharma
authors.forename: Razvan
authors.initials: R
authors.lastname: Ionasec
authors.forename: Dime
authors.initials: D
authors.lastname: Vitanovski
authors.forename: Waldemar
authors.initials: W
authors.lastname: Krawtschuk
authors.forename: Allen
authors.initials: A
authors.lastname: Everett
authors.forename: Richard
authors.initials: R
authors.lastname: Ringel
authors.forename: Nassir
authors.initials: N
authors.lastname: Navab
authors.forename: Dorin
authors.initials: D
authors.lastname: Comaniciu
mesh_terms: D001011:Aorta / Q000473:pathology / Q000503:physiopathology*; D001017:Aortic Coarctation / Q000473:pathology / Q000503:physiopathology*; D001783:Blood Flow Velocity; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity