title: Preparation of magnetic gelatin nanoparticles and investigating the possible use as chemotherapeutic agent.
abstract: Iron oxide nanoparticles coated with gelatin trough two-step desolvation method and characterized. SEM analyse showed that the nanoparticles are spherical and TEM image showed that the iron oxide nanoparticles encapsulated with gelatin. Also FTIR, TG and magnetization analyses exhibited that iron oxide nanoparticles encapsulated as well. Drug loading by adsorption studied under various conditions as different temperature, contact time and initial cisplatin concentration. Also, Langmuir, Freundlich and Dubinin-Raduskevich adsorption isotherm curves were constracted and constants were calculated. In vitro drug release was performed at pH 5 and 7.4 and hyperthermic drug release investigated at 42°C and compared with non-hyperthermic drug release.
authors.affiliation: Department of Biochemistry, Faculty of Science, Ege University, Izmir, Turkey. yilmaz.habibe@hotmail.com
authors.forename: Habibe
authors.initials: H
authors.lastname: Yılmaz
authors.forename: Senay Hamarat
authors.initials: SH
authors.lastname: Sanlıer
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D002945:Cisplatin / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis*; D004339:Drug Compounding; D005290:Ferric Compounds / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008854:Microscopy, Electron; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013816:Thermodynamics
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D005780:Gelatin; D002945:Cisplatin