title: [Medical termination of pregnancy in a patient with severe cystic fibrosis. Possible effect of the antiglucocorticoid action of mifepristone on the respiratory disease].
abstract: Better management of patients with cystic fibrosis has resulted in an increased rate of pregnancy, especially in mild forms. In case of severe respiratory impairment, physiological changes occurring during pregnancy can be life threatening. Medical termination of pregnancy may be necessary. We report a case of severe cystic fibrosis requiring a termination of pregnancy due to significant maternal risk at 17 weeks of gestation. Mifepristone used for induction of labor has a well-known antiglucocorticoid action. We discuss here its potential effect on the onset of an acute pulmonary failure in this patient with long-term corticosteroid therapy.
authors.affiliation: Maternité régionale de Nancy, 10, rue du Docteur-Heydenreich, 54000 Nancy, France.
authors.forename: P
authors.initials: P
authors.lastname: Guerci
authors.forename: F
authors.initials: F
authors.lastname: Vial
authors.forename: J
authors.initials: J
authors.lastname: Raft
authors.forename: U Mc
authors.initials: UM
authors.lastname: Nelis
authors.forename: S
authors.initials: S
authors.lastname: Mory
authors.forename: O
authors.initials: O
authors.lastname: Morel
authors.forename: H
authors.initials: H
authors.lastname: Bouaziz
mesh_terms: D000021:Abortifacient Agents, Steroidal / Q000009:adverse effects*; D000028:Abortion, Induced / Q000379:methods*; D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000628:therapy*; D015735:Mifepristone / Q000009:adverse effects*; D016343:Monitoring, Intraoperative; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*
chemical_list: D000021:Abortifacient Agents, Steroidal; D015735:Mifepristone