title: Selenium in bone health: roles in antioxidant protection and cell proliferation.
abstract: Selenium (Se) is an essential trace element for humans and animals, and several findings suggest that dietary Se intake may be necessary for bone health. Such findings may relate to roles of Se in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Elucidation of the mechanisms by which Se supports these cellular processes can lead to a better understanding of the role of this nutrient in normal bone metabolism. This article reviews the current knowledge concerning the molecular functions of Se relevant to bone health.
authors.affiliation: Grand Forks Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Grand Forks, ND 58202, USA. huawei.zeng@ars.usda.gov
authors.forename: Huawei
authors.initials: H
authors.lastname: Zeng
authors.forename: Jay J
authors.initials: JJ
authors.lastname: Cao
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Combs
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D016723:Bone Remodeling / Q000187:drug effects* / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D012643:Selenium / Q000494:pharmacology*; D018036:Selenium Compounds / Q000494:pharmacology; D051140:Selenoproteins / Q000502:physiology
chemical_list: D000975:Antioxidants; D018036:Selenium Compounds; D051140:Selenoproteins; D012643:Selenium