title: Primary ovarian adenosarcoma with elevated Ca-125 levels and normal ascitic fluid cytology: a case report and review of literature.
abstract: OBJECTIVE
  Ovarian adenosarcoma is a very rare tumour for which treatment options vary. We will consider the option of optimal cytoreductive surgery followed by adjuvant chemotherapy consisting of ifosamide (mesna) and adriamycin to prevent systemic metastasis, and will observe the role of serial CA-125 levels as a follow-up marker.
  
  
  METHODS
  We report a case of ovarian adenosarcoma in a 38-year-old woman presenting with abdominal pain, distention due to massive ascites. She had undergone total abdominal hysterectomy 8 months previously for abnormal uterine bleeding. She underwent paracentesis followed by optimal cytoreductive surgery. A post-operative histopathologic diagnosis of primary adenosarcoma was confirmed. She was assigned a stage III C cancer. She received five cycles of ifosamise (mesna) and adriamycin and is on follow-up with serial CA-125 levels. There is no evidence of recurrence clinically, biochemically, or radiologically for more than 12 months.
  
  
  CONCLUSIONS
  Multimodality treatment comprising optimal cytoreductive surgery followed by ifosamide (mesna) and adriamycin-based chemotherapy may be an option for treatment of these aggressive tumours. Follow-up with serial CA-125 values in advanced stage adenosarcoma of the ovary is a novel observation which needs to be researched.
authors.affiliation: Department of Gynaecologic Oncology, Kidwai Memorial Institute of Oncology, Dr. M.H. Mari Gowda Road, Bengaluru 560029, Karnataka, India.
authors.forename: Pn
authors.initials: P
authors.lastname: Shakuntala
authors.forename: K
authors.initials: K
authors.lastname: Umadevi
authors.forename: A
authors.initials: A
authors.lastname: Usha
authors.forename: N
authors.initials: N
authors.lastname: Abhilasha
authors.forename: Ud
authors.initials: U
authors.lastname: Bafna
keywords: CA-125; adenosarcoma ovary; ascitic fluid cytology; chemotherapy