title: New insights in the topology of the biosynthesis of 5-aminolevulinic acid.
abstract: The formation of 5-aminolevulinic acid (ALA) at the beginning of the pathway is the rate limiting step of tetrapyrrole biosynthesis and target of multiple timely and spatially organized control mechanisms. Recent discovery of a glutamyl-tRNA reductase-binding protein (GluTRBP), reveals a new insight in the topology of regulation of plant ALA biosynthesis.
authors.affiliation: Humboldt-Universität zu Berlin; Institute of Biology; Department of Plant Physiology; Berlin, Germany; Oak Ridge National Laboratory, Biosciences Division, Plant Systems Biology, Oak Ridge, TN USA.
authors.forename: Olaf
authors.initials: O
authors.lastname: Czarnecki
authors.affiliation: Humboldt-Universität zu Berlin; Institute of Biology; Department of Plant Physiology; Berlin, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Grimm
mesh_terms: D000622:Aminolevulinic Acid / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant / Q000502:physiology; D010940:Plant Proteins / Q000378:metabolism*
chemical_list: D010940:Plant Proteins; D000622:Aminolevulinic Acid
keywords: ALA synthesis; GSAT; GluTR; GluTRBP