title: Similarity-based appearance-prior for fitting a subdivision mesh in gene expression images.
abstract: Automated segmentation of multi-part anatomical objects in images is a challenging task. In this paper, we propose a similarity-based appearance-prior to fit a compartmental geometric atlas of the mouse brain in gene expression images. A subdivision mesh which is used to model the geometry is deformed using a Markov random field (MRF) framework. The proposed appearance-prior is computed as a function of the similarity between local patches at corresponding atlas locations from two images. In addition, we introduce a similarity-saliency score to select the mesh points that are relevant for the computation of the proposed prior. Our method significantly improves the accuracy of the atlas fitting, especially in the regions that are influenced by the selected similarity-salient points, and outperforms the previous subdivision mesh fitting methods for gene expression images.
authors.affiliation: Computational Biomedicine Lab, University of Houston, Houston, TX, USA.
authors.forename: Yen H
authors.initials: YH
authors.lastname: Le
authors.forename: Uday
authors.initials: U
authors.lastname: Kurkure
authors.forename: Nikos
authors.initials: N
authors.lastname: Paragios
authors.forename: Tao
authors.initials: T
authors.lastname: Ju
authors.forename: James P
authors.initials: JP
authors.lastname: Carson
authors.forename: Ioannis A
authors.initials: IA
authors.lastname: Kakadiaris
mesh_terms: D000465:Algorithms; D000818:Animals; D001185:Artificial Intelligence; D001331:Automation; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008390:Markov Chains; D051379:Mice; D015233:Models, Statistical; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012984:Software