title: Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition             of NF-κB-dependent MMP-9 expression.
abstract: Cell invasion is required for neoplastic metastasis. Matrix metalloproteinase-9             (MMP-9), which degrades the extracellular matrix, is a major component in the             process of cancer cell invasion. Sulfuretin is one of the major flavonoids isolated             from Rhus verniciflua. Sulfuretin has been used to reduce oxidative stress, platelet             aggregation, the inflammatory response and mutagenesis. However, the effect of             sulfuretin on breast cancer metastasis is unknown. In this study, we investigated             the inhibitory effect of sulfuretin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced             MMP-9 expression and cell invasion in MCF-7 cells. Sulfuretin inhibited TPA-induced             transcriptional activation of nuclear factor-κB (NF-κB). We demonstrated that             sulfuretin mediated the inhibition of TPA-induced MMP-9 expression and that cell             invasion in MCF-7 cells involved suppression of the NF-κB pathway. Therefore,             inhibiting MMP-9 expression by sulfuretin may have therapeutic potential for controlling             breast cancer invasiveness.
authors.affiliation: Center for Metabolic Function Regulation, Wonkwang University                     School of Medicine, Iksan 570-749, Republic of Korea.
authors.forename: Jeong-Mi
authors.initials: JM
authors.lastname: Kim
authors.forename: Eun-Mi
authors.initials: EM
authors.lastname: Noh
authors.forename: Kang-Beom
authors.initials: KB
authors.lastname: Kwon
authors.forename: Jong-Suk
authors.initials: JS
authors.lastname: Kim
authors.forename: Yong-Ouk
authors.initials: YO
authors.lastname: You
authors.forename: Jin-Ki
authors.initials: JK
authors.lastname: Hwang
authors.forename: Bo-Mi
authors.initials: BM
authors.lastname: Hwang
authors.forename: Min Seuk
authors.initials: MS
authors.lastname: Kim
authors.forename: Seung-Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Sung-Hoo
authors.initials: SH
authors.lastname: Jung
authors.forename: Hyun-Jo
authors.initials: HJ
authors.lastname: Youn
authors.forename: Eun-Yong
authors.initials: EY
authors.lastname: Chung
authors.forename: Young-Rae
authors.initials: YR
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001572:Benzofurans / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000494:pharmacology; D006801:Humans; D020935:MAP Kinase Signaling System; D061986:MCF-7 Cells; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009361:Neoplasm Invasiveness; D011485:Protein Binding; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D018808:Transcription Factor AP-1 / Q000378:metabolism; D015533:Transcriptional Activation / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; D005419:Flavonoids; D016328:NF-kappa B; D018808:Transcription Factor AP-1; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9; C054989:sulfuretin; D013755:Tetradecanoylphorbol Acetate