title: Indacaterol improves daily physical activity in patients with chronic obstructive pulmonary disease.
abstract: BACKGROUND
  The current mainstay of therapy for chronic obstructive pulmonary disease (COPD) is long-acting bronchodilators. To date, the effect of indacaterol, a β2-agonist, on activities of daily living in COPD patients is not well understood. The aim of this study was to evaluate the efficacy of indacaterol with regard to activities of daily living in patients with COPD.
  
  
  METHODS
  In this nonrandomized open-label study, 23 patients with COPD were instructed to carry an accelerometer for 4 weeks without indacaterol therapy and then for another period of 4 weeks while receiving indacaterol therapy.
  
  
  RESULTS
  The number of steps, duration of moderate or greater physical activity, and energy expenditure were significantly increased after treatment with indacaterol compared with baseline data in all patients with COPD; the metabolic equivalent of task was also significantly enhanced after treatment with indacaterol.
  
  
  CONCLUSIONS
  This study provides early evidence that indacaterol improves daily physical activity in patients with COPD.
authors.affiliation: Respiratory Center, Matsusaka Municipal Hospital, Tonomachi.
authors.forename: Osamu
authors.initials: O
authors.lastname: Hataji
authors.forename: Masahiro
authors.initials: M
authors.lastname: Naito
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ito
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Watanabe
authors.forename: Esteban C
authors.initials: EC
authors.lastname: Gabazza
authors.forename: Osamu
authors.initials: O
authors.lastname: Taguchi
mesh_terms: D061725:Accelerometry; D058666:Adrenergic beta-2 Receptor Agonists / Q000627:therapeutic use*; D000368:Aged; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D015363:Quinolones / Q000627:therapeutic use*
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D001993:Bronchodilator Agents; D007189:Indans; D015363:Quinolones; C510790:indacaterol
keywords: chronic obstructive pulmonary disease; indacaterol; long-acting β2-agonist; physical activity