title: The impact of structure on oxidatively generated DNA damage products resulting from the C3'-thymidinyl radical.
abstract: What's the damage? Trapping the C3'-thymidinyl radical in biologically significant architectures delivers both the repaired oligomer and 1-(2'-deoxy-β-D-threo-pentofuranosyl)thymidine-containing substrates. The stereoselectivity of the reduction was found to be dependent upon the DNA structure.
authors.affiliation: Department of Chemistry, The University of Toledo, 2801 W. Bancroft St., Toledo, OH 43606-3390, USA.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Amato
authors.forename: Amanda C
authors.initials: AC
authors.lastname: Bryant-Friedrich
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D004249:DNA Damage; D005609:Free Radicals / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013936:Thymidine / Q000737:chemistry*
chemical_list: D005609:Free Radicals; D004247:DNA; D013936:Thymidine