title: Enantioseparations of primary amino compounds by high-performance liquid chromatography using chiral crown ether-based chiral stationary phase.
abstract: Liquid chromatographic resolution of racemic compounds containing a primary amino group has been known to be most successful when chiral crown ether-based chiral stationary phases (CSPs) are used. Among various crown ether-based CSPs, the stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid covalently bonded to silica gel has been successfully applied in the resolution of various racemic compounds containing primary amino groups. In this chapter, the preparation of the CSP based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid covalently bonded to silica gel and examples for the application to the enantioseparation of racemic compounds including α-amino acids, cyclic amines, amino alcohols, and chiral drugs are described.
authors.affiliation: Department of Chemistry and Chemistry, Pusan National University, Busan, South Korea. mhhyun@pusan.ac.kr
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Hyun
mesh_terms: D000588:Amines / Q000032:analysis / Q000737:chemistry; D000596:Amino Acids / Q000032:analysis / Q000737:chemistry; D000605:Amino Alcohols / Q000032:analysis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods*; D043844:Crown Ethers / Q000032:analysis / Q000737:chemistry*; D058428:Silica Gel / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D000596:Amino Acids; D000605:Amino Alcohols; D043844:Crown Ethers; C090732:18-crown-6 2,3,11,12-tetracarboxylic acid; D058428:Silica Gel