title: Enantioseparations by capillary electrophoresis using cyclodextrins as chiral selectors.
abstract: Due to their commercial availability, cyclodextrins are the most frequently used chiral selectors in capillary electrophoresis as documented by the numerous publications in the field. A variety of migration modes can be realized depending on the characteristics of the cyclodextrins and the analytes. The basic considerations regarding the development of a chiral CE method employing cyclodextrins as chiral selectors are briefly discussed. The presented examples illustrate the separation modes of an acidic and a basic analyte with native and charged cyclodextrin derivatives as a function of the pH of the background electrolyte and the cyclodextrin concentration.
authors.affiliation: Department of Pharmaceutical/Medicinal Chemistry, Friedrich Schiller University Jena, Jena, Germany. gerhard.scriba@uni-jena.de
authors.forename: Gerhard K E
authors.initials: GK
authors.lastname: Scriba
authors.forename: Pavel
authors.initials: P
authors.lastname: Jáč
mesh_terms: D003505:Cyclodextrins / Q000032:analysis* / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D058428:Silica Gel; D013237:Stereoisomerism
chemical_list: D003505:Cyclodextrins; D058428:Silica Gel