title: Development of mucinous adenocarcinoma in chronic Crohn's disease fistulae without luminal involvement.
abstract: A patient with Crohn's disease who developed mucinous adenocarcinoma in chronic fistulae is reported. Malignancy may complicate chronic nonhealing Crohn's sinus tracts and fistulae, even with no mucosal involvement by carcinoma. Persistent non-remitting perianal induration and pain should alert the physician to the possibility of underlying malignancy. Prompt examination under anesthesia and biopsy or fine-needle aspiration may facilitate diagnosis and therapy of the carcinoma at an early stage.
authors.affiliation: *Division of Gastroenterology, and †Department of Surgery, University of Texas Houston Health Science Center; and Departments of ‡Surgical Oncology and §Radiotherapy, University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: N V
authors.initials: NV
authors.lastname: Inamdar
authors.forename: P
authors.initials: P
authors.lastname: Schwarz
authors.forename: H R
authors.initials: HR
authors.lastname: Bailey
authors.forename: J M
authors.initials: JM
authors.lastname: Skibber
authors.forename: T A
authors.initials: TA
authors.lastname: Rich
authors.forename: J
authors.initials: J
authors.lastname: Sellin