title: [SKF index as a new non-invasive parameter for the evaluation of the biological age for healthy and sick people].
abstract: We have conducted a study on a large group of healthy and sick subjects and have demonstrated that a new index of coagulativety (SKF), based on measurement of the laser speckle signal from the finger root, correlates with chronological age ranging from 1 to 85 years old. The kinds of non-invasive measurements were obtained during two measurement sessions: one with the application of over-systolic occlusion and another without application of the occlusion. The very significant correlation with age was noted both during the stasis stage and during the non-occluding stage. We observed a higher SKF index in sick subjects, correlating directly with severity of illness. We speculated that the observed phenomena are caused by temporarily fluctuations in local blood viscosity associated with interactions of the Red Blood Cells and endothelial cells.
authors.forename: I A
authors.initials: IA
authors.lastname: Faĭn
authors.forename: B I
authors.initials: BI
authors.lastname: Kuznik
authors.forename: A V
authors.initials: AV
authors.lastname: Kaminskiĭ
authors.forename: L
authors.initials: L
authors.lastname: Shenkman
authors.forename: E M
authors.initials: EM
authors.lastname: Kustovskaia
authors.forename: O G
authors.initials: OG
authors.lastname: Maksimova
mesh_terms: D000375:Aging / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology*; D001809:Blood Viscosity / Q000502:physiology*; D003935:Diagnostic Techniques, Cardiovascular; D006801:Humans; D012016:Reference Values; D012720:Severity of Illness Index