title: In acute promyelocytic leukemia (APL) low BAALC gene expression identifies a patient group with favorable overall survival and improved relapse free survival.
abstract: We evaluated the prognostic value of BAALC expression in 86 patients with acute promyelocytic leukemia (APL). At 10 years, the overall survival (OS) was 66% in all patients and 75% in patients who achieved a complete remission (CR). Patients in the BAALC(low) group showed an OS of 87% as compared to 60% in the BAALC(high) group (p=0.019). This difference was more pronounced in treatment responders (92% vs. 70%; p=0.035). In multivariate analyses low BAALC expression retained its prognostic relevance. In conclusion, BAALC expression analysis might be useful in further risk stratification in APL patients.
authors.affiliation: Department of Hematology and Oncology, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany. florian.nolte@medma.uni-heidelberg.de
authors.forename: Florian
authors.initials: F
authors.lastname: Nolte
authors.forename: Anna
authors.initials: A
authors.lastname: Hecht
authors.forename: Mark
authors.initials: M
authors.lastname: Reinwald
authors.forename: Daniel
authors.initials: D
authors.lastname: Nowak
authors.forename: Verena
authors.initials: V
authors.lastname: Nowak
authors.forename: Benjamin
authors.initials: B
authors.lastname: Hanfstein
authors.forename: Andreas
authors.initials: A
authors.lastname: Faldum
authors.forename: Thomas
authors.initials: T
authors.lastname: Büchner
authors.forename: Karsten
authors.initials: K
authors.lastname: Spiekermann
authors.forename: Cristina
authors.initials: C
authors.lastname: Sauerland
authors.forename: Wolf-Karsten
authors.initials: WK
authors.lastname: Hofmann
authors.forename: Eva
authors.initials: E
authors.lastname: Lengfelder
mesh_terms: D000328:Adult; D000368:Aged; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D015870:Gene Expression; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D012008:Recurrence; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013534:Survival
chemical_list: C442828:BAALC protein, human; D017931:DNA Primers; D009363:Neoplasm Proteins