title: Eco-friendly synthesis of size-controllable amine-functionalized graphene quantum dots with antimycoplasma properties.
abstract: Size-controllable amine-functionalized graphene quantum dots (GQDs) are prepared by an eco-friendly method with graphene oxide sheets, ammonia and hydrogen peroxide as starting materials. Using a Sephadex G-25 gel column for fine separation, for the first time we obtain GQDs with either single or double layers. By atomic force microscopy characterization, we confirm that hydrogen peroxide and ammonia play a synergistic role on graphene oxide (GO), in which the former cuts the GO into small pieces and the latter passivates the active surface to give amine-modified GQDs. Due to the low cytotoxicity and excellent biocompatibility of the obtained amine-functionalized GQDs, besides the multiwavelength imaging properties of GQDs, for the first time we find that this kind of GQD exhibits good antimycoplasma properties. Given the superior antimycoplasma effect of the GQDs and their eco-friendly mass production with low cost, these new GQDs may offer opportunities for the development of new antimycoplasma agents, thus extending their widespread application in biomedicine.
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.forename: Daiqin
authors.initials: D
authors.lastname: Chen
authors.forename: Ruimin
authors.initials: R
authors.lastname: Li
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Zhang
authors.forename: Shumu
authors.initials: S
authors.lastname: Li
authors.forename: Junpeng
authors.initials: J
authors.lastname: Zheng
authors.forename: Naiyan
authors.initials: N
authors.lastname: Huang
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu
authors.forename: Chunru
authors.initials: C
authors.lastname: Wang
authors.forename: Chunying
authors.initials: C
authors.lastname: Shu
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology*; D055772:Green Chemistry Technology; D006367:HeLa Cells; D006801:Humans; D008422:Materials Testing; D009174:Mycoplasma / Q000187:drug effects / Q000502:physiology*; D045663:Quantum Dots
chemical_list: D000588:Amines; D000900:Anti-Bacterial Agents; D006108:Graphite