title: Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient.
abstract: We report a female patient with rheumatoid arthritis which was refractory to methotrexate, leflunomide, and anti-TNF therapy. She was treated with anti-IL-6 tocilizumab (TCZ), with an early appearance of sterile pustules on erythematous swollen skin of trunk, back, and abdominal area. The lesions were consistent with the diagnosis of acute drug-related generalized exanthematous pustulosis (AGEP). This adverse event was controlled with medical treatment without requiring removal of TCZ.
authors.affiliation: Rheumatology Unit, Valle del Lili Foundation, ICESI University, Cali, Colombia.
authors.forename: J H
authors.initials: JH
authors.lastname: Izquierdo
authors.forename: F
authors.initials: F
authors.lastname: Bonilla-Abadía
authors.forename: C D
authors.initials: CD
authors.lastname: Ochoa
authors.forename: A
authors.initials: A
authors.lastname: Agualimpia
authors.forename: G J
authors.initials: GJ
authors.lastname: Tobón
authors.forename: C A
authors.initials: CA
authors.lastname: Cañas