title: Mechanistic modelling of drug release from a polymer matrix using magnetic resonance microimaging.
abstract: In this paper a new model describing drug release from a polymer matrix tablet is presented. The utilization of the model is described as a two step process where, initially, polymer parameters are obtained from a previously published pure polymer dissolution model. The results are then combined with drug parameters obtained from literature data in the new model to predict solvent and drug concentration profiles and polymer and drug release profiles. The modelling approach was applied to the case of a HPMC matrix highly loaded with mannitol (model drug). The results showed that the drug release rate can be successfully predicted, using the suggested modelling approach. However, the model was not able to accurately predict the polymer release profile, possibly due to the sparse amount of usable pure polymer dissolution data. In addition to the case study, a sensitivity analysis of model parameters relevant to drug release was performed. The analysis revealed important information that can be useful in the drug formulation process.
authors.affiliation: Department of Chemical Engineering, LTH, Lund University, P.O. Box 124, Lund SE-221 00, Sweden. erik.kaunisto@chalmers.se
authors.forename: Erik
authors.initials: E
authors.lastname: Kaunisto
authors.forename: Farhad
authors.initials: F
authors.lastname: Tajarobi
authors.forename: Susanna
authors.initials: S
authors.lastname: Abrahmsen-Alami
authors.forename: Anette
authors.initials: A
authors.lastname: Larsson
authors.forename: Bernt
authors.initials: B
authors.lastname: Nilsson
authors.forename: Anders
authors.initials: A
authors.lastname: Axelsson
mesh_terms: D020342:Finite Element Analysis; D065347:Hypromellose Derivatives; D008279:Magnetic Resonance Imaging; D008353:Mannitol / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D008962:Models, Theoretical; D015203:Reproducibility of Results; D013607:Tablets / Q000737:chemistry*
chemical_list: D013607:Tablets; D065347:Hypromellose Derivatives; D008353:Mannitol; D008747:Methylcellulose