title: [Factors influencing finasteride medication compliance in outpatients with benign prostatic hyperplasia].
abstract: OBJECTIVE
  To investigate the factors influencing the compliance, discontinuation and switching of finasteride medication in patients with benign prostatic hyperplasia (BPH).
  
  
  METHODS
  We retrospectively analyzed the electronic clinical data of 655 outpatients with BPH treated with finasteride from January 2008 to June 2010. Using the medication possession ratio (MPR), we measured their medication compliance and the rates of discontinuation and switching after an average observation of 12 months. We identified and evaluated the influencing factors by multivariate logistic regression analysis.
  
  
  RESULTS
  The crude rates of medication compliance, discontinuation and switching were 32.4%, 58.0% and 9.6%, respectively. In those aged > or = 60 years, combination therapy of finasteride with alpha-receptor blockers and chronic comorbidities were positively associated with good compliance, while younger age was significantly associated with drug discontinuation or switching. Finasteride monotherapy was significantly associated with discontinuation of the drug.
  
  
  CONCLUSIONS
  Patients aged < 60 years and those receiving monotherapy were less likely to be compliant with newly initiated finasteride medication, and therefore more efforts should be made to increase their medication adherence.
authors.affiliation: Department of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. scalpel@163.com
authors.forename: Yun-Hua
authors.initials: YH
authors.lastname: Lin
authors.forename: Jun-Sheng
authors.initials: JS
authors.lastname: Wang
authors.forename: Yong-Guang
authors.initials: YG
authors.lastname: Jiang
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D018120:Finasteride / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D010045:Outpatients; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D018120:Finasteride