title: [Diffusion tensor imaging analyses of white matter in healthy siblings of schizophrenics].
abstract: OBJECTIVE
  To explore the diffusion tensor imaging (DTI) features of white matter in healthy siblings of schizophrenics.
  
  
  METHODS
  Twenty healthy siblings of schizophrenics and 45 healthy controls without a family history of mental disorder. They responded to advertised recruitment during December 2009 and March 2012. All participants underwent diffusion weighted magnetic resonance images with a single-shot echo planar imaging (EPI) sequence aligned to straight axial plane. The fractional anisotropy (FA) images of two groups underwent two-sample t-test with SPM5 software.
  
  
  RESULTS
  The healthy siblings of schizophrenics demonstrated a significant decrease of regional white matter FA values in right anterior cingulated (MNI: x = 9, y = 43, z = 4; cluster = 106).
  
  
  CONCLUSIONS
  Reduced white matter integrity in right anterior cingulated may be a risk actor of schizophrenia.
authors.affiliation: Department of Radiology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Kang
authors.forename: Qin-ling
authors.initials: QL
authors.lastname: Wei
authors.forename: Yan-xia
authors.initials: YX
authors.lastname: Tang
authors.forename: Lei-jun
authors.initials: LJ
authors.lastname: Li
authors.forename: Liang-rong
authors.initials: LR
authors.lastname: Zheng
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Guo
authors.forename: Jin-bei
authors.initials: JB
authors.lastname: Zhang
authors.forename: Jing-ping
authors.initials: JP
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D016022:Case-Control Studies; D038524:Diffusion Magnetic Resonance Imaging; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D012559:Schizophrenia; D035781:Siblings; D055815:Young Adult