title: Risk factors correlated with risk of insulin resistance using homeostasis model assessment in adolescents in Taiwan.
abstract: The study aims to discover risk factors significantly correlated with insulin resistance among adolescents in Taiwan. A total of 339 study subjects were recruited in this cross-sectional study. A self-administered questionnaire and physical examinations including anthropometrics and biochemistry profiles were collected. Insulin resistance was assessed using homeostasis model assessment for insulin resistance (HOMA-IR). Study subjects had a significantly increased risk of IR for those with abnormal level of body mass index (odds ratio [OR] = 3.54; 95% confidence interval [CI] = 1.81-6.91), body fat (OR = 2.71; 95% CI = 1.25-5.88), and waist circumference (OR = 25.04; 95% CI = 2.93-214.14) when compared with those who have normal values. Furthermore, a significantly joint effect of 10.86-fold risk for HOMA-IR abnormality among body fat, body mass index, and systolic blood pressure was observed. The identification of risk factors significantly correlated with IR will be important to prevent metabolic syndrome-related diseases and complications for adolescents in their future life.
authors.affiliation: Taipei Medical University, Taipei, Taiwan Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: Shiyng-Yu
authors.initials: SY
authors.lastname: Lin
authors.affiliation: Taipei Medical University, Taipei, Taiwan Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: Chien-Tien
authors.initials: CT
authors.lastname: Su
authors.affiliation: Taipei Medical University, Taipei, Taiwan.
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Hsieh
authors.affiliation: Taipei Medical University, Taipei, Taiwan.
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Li
authors.affiliation: Taipei Medical University, Taipei, Taiwan.
authors.forename: Yih-Ru
authors.initials: YR
authors.lastname: Chen
authors.affiliation: Taipei Medical University, Taipei, Taiwan.
authors.forename: Shu-Yun
authors.initials: SY
authors.lastname: Cheng
authors.affiliation: Taipei Medical University, Taipei, Taiwan Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: Chien-Ming
authors.initials: CM
authors.lastname: Hu
authors.affiliation: Taipei Medical University, Taipei, Taiwan.
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Taipei Medical University, Taipei, Taiwan.
authors.forename: Fang-I
authors.initials: FI
authors.lastname: Hsieh
authors.affiliation: Taipei Medical University, Taipei, Taiwan hychiou@tmu.edu.tw.
authors.forename: Hung-Yi
authors.initials: HY
authors.lastname: Chiou
mesh_terms: D000293:Adolescent; D001794:Blood Pressure; D015992:Body Mass Index; D001837:Body Weights and Measures; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D016017:Odds Ratio; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D055105:Waist Circumference
keywords: HOMA-IR; adolescents; insulin resistance; metabolic syndrome; risk factors