title: Higher protein diet for weight management in young overweight women: a 12-month randomized controlled trial.
abstract: Clinical research on weight management in young women is limited. This randomized controlled trial compared the efficacy of two iso-energetically restricted (5600 kJ) diets [higher protein (HP): 32% protein, 41% carbohydrate, 25% fat or higher carbohydrate (HC): 20, 58, 21%, respectively] in 71 (HP: n = 36; HC: n = 35) young healthy women (18-25 years; body mass index ≥ 27.5 kg/m2) for weight (kg; percent weight loss), body composition, metabolic and iron changes assessed at baseline, 6 and 12 months.
  
  
  METHODS
  mean (95% CI). In HP completers at 6 months, percent weight loss was higher [HP: 9.3 (5.6-13.1); HC: 5.1 (2.3-7.9)%; p = 0.06]; although, this did not reach statistical significance. Absolute weight [HP: 8.9 (5.3-12.5); HC: 4.6 (2.2-7.0) kg; p = 0.034] and fat loss [HP: 8.0 (4.4-11.5); HC: 3.4 (1.3-5.6) kg; p = 0.022] were significantly greater. No significant between-diet differences were observed at 12 months. Biochemistry remained within normal ranges with HP showing superior preservation of ferritin at 6 months [HP: 53 (40-66); HC: 46 (30-61) µg/l; p = 0.029]. Both diets supported clinically meaningful weight loss with HP tending to be more effective in the medium-term.
authors.affiliation: Discipline of Exercise and Sport Science, Faculty of Health Sciences, The University of Sydney, Sydney, Australia.
authors.forename: H J
authors.initials: HJ
authors.lastname: Griffin
authors.forename: H L
authors.initials: HL
authors.lastname: Cheng
authors.forename: H T
authors.initials: HT
authors.lastname: O'Connor
authors.forename: K B
authors.initials: KB
authors.lastname: Rooney
authors.forename: P
authors.initials: P
authors.lastname: Petocz
authors.forename: K S
authors.initials: KS
authors.lastname: Steinbeck
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D004038:Diet, Reducing / Q000379:methods*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005247:Feeding Behavior; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D050177:Overweight / Q000097:blood / Q000517:prevention & control*; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D005293:Ferritins