title: Mixed mucin-producing and squamous differentiated tumor of the uterine cervix: a report of a case as adenosquamous carcinoma in situ.
abstract: We report a non-invasive mixed mucin-producing and squamous differentiated tumor of the uterine cervix. This tumor was composed of two cell types: mucin-producing cells and non-mucin-producing cells. These cells were intimately mixed with each other, and showed intraepithelial spreading. The mucin-producing cells showed signet-ring or columnar shapes, and were localized to the lower-to-upper epithelial layer. The non-mucin-producing cells had eosinophilic cytoplasms with a monotonous appearance through the epithelium. Mitosis was sometimes observed in both cell types. Immunohistochemically, both cell types were positive for p16(INK4A) . The non-mucin-producing cells were positive for p63 and 34βE12, suggesting squamous differentiation. Although most mucin-producing cells were p63(-) , a few of them were p63(+)  and many 34βE12 immunoreactive cells were found in the mucin-producing cells. This tumor was adenosquamous carcinoma in situ.
authors.affiliation: Department of Pathology Second Department of Pathology, Showa University, Tokyo, Japan. yomareko@cmed.showa-u.ac.jp
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Ohta
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kunimura
authors.forename: Mutsuko
authors.initials: M
authors.lastname: Omatsu
authors.forename: Akira
authors.initials: A
authors.lastname: Shiokawa
authors.forename: Miki
authors.initials: M
authors.lastname: Kushima
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Ota
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000378:metabolism / Q000473:pathology*; D018196:Carcinoma, Adenosquamous / Q000378:metabolism / Q000473:pathology*; D002584:Cervix Uteri / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D009077:Mucins / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D009077:Mucins