title: Copper- and iron-catalyzed decarboxylative tri- and difluoromethylation of α,β-unsaturated carboxylic acids with CF3SO2Na and (CF2HSO2)2Zn via a radical process.
abstract: A copper-catalyzed decarboxylative trifluoromethylation of various α,β-unsaturated carboxylic acids by using a stable and inexpensive solid, sodium trifluoromethanesulfinate (CF(3)SO(2)Na, Langlois reagent), was developed. In addition, an iron-catalyzed difluoromethylation of aryl-substituted acrylic acids by using zinc difluoromethanesulfinate (DFMS, (CF(2)HSO(2))(2)Zn, Baran reagent) via a similar radical process was also achieved.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou Gansu 730000, PR China.
authors.forename: Zejiang
authors.initials: Z
authors.lastname: Li
authors.forename: Zili
authors.initials: Z
authors.lastname: Cui
authors.forename: Zhong-Quan
authors.initials: ZQ
authors.lastname: Liu
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry
chemical_list: D000475:Alkenes; D002264:Carboxylic Acids; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D003300:Copper; D007501:Iron; D015032:Zinc