title: Burkitt lymphoma arising from lymphoplasmacytic lymphoma following acquisition of MYC translocation and loss of the ETV6 tumor suppressor gene.
abstract: Lymphoplasmacytic lymphoma is a mature B-cell lymphoma with variable plasmacytic differentiation that displays an indolent clinical course. Its transformation to a high-grade B-cell lymphoma may occur uncommonly. Although acquisition of a MYC translocation could result in transformation of a low-grade lymphoma into diffuse large B-cell lymphoma, Burkitt lymphoma, or B-lymphoblastic leukemia, to our knowledge the latter 2 transformations have not been well documented in lymphoplasmacytic lymphoma. We report the case of a 70-year-old woman with a 9-year history of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia who presented with rapid enlargement of a left neck mass and pancytopenia, which was diagnosed as Burkitt lymphoma with extensive bone marrow involvement. A series of histopathologic, molecular, and cytogenetic evaluations proved a cytogenetic evolution including t(8;14)(q24;q32)/MYC-IgH and identical clonal B-cell gene rearrangements from the 2 distinct lymphomas, confirming stage 4 aggressive Burkitt lymphoma arising from lymphoplasmacytic lymphoma.
authors.affiliation: Department of Hematopathology & Laboratory Medicine, Moffitt Cancer Center, Tampa, Florida 33612, USA.
authors.forename: Deniz
authors.initials: D
authors.lastname: Peker
authors.forename: Brian
authors.initials: B
authors.lastname: Quigley
authors.forename: Dahui
authors.initials: D
authors.lastname: Qin
authors.forename: Peter
authors.initials: P
authors.lastname: Papenhausen
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000368:Aged; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000473:pathology*; D020732:Cytogenetic Analysis; D005260:Female; D017353:Gene Deletion; D015322:Gene Rearrangement, B-Lymphocyte; D016147:Genes, Tumor Suppressor; D016259:Genes, myc; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D013997:Time Factors; D014178:Translocation, Genetic; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics* / Q000473:pathology*; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D000097764:ETS Translocation Variant 6 Protein