title: Serotonin 5-HT1A receptor in infancy-onset aggression: comparison with genetically defined aggression in adult rats.
abstract: Antisocial aggressive behavior in adolescents represents growing clinical and social problem. Previously the implication of 5-HT1A receptor in the regulation of fear-induced aggression was shown. Here, the involvement of 5-HT1A receptor in infancy-onset genetically defined aggression was studied on Norway rats selectively bred for high level or for the lack of aggression toward man. The aggressive behavior and the expression of 5-HT1A receptor gene, 5-HT1A receptor density and functional activity were determined in infant (15-day-old) and adult rats. Considerable differences in aggressive response to man between infant rats of aggressive (A) and nonaggressive (NA) strains were found. In contrast to infant NA rats, A infants elicited marked aggressive response to handling, although its expression was less than in adult A rats. 5-HT1A receptor agonist 8-OH-DPAT (0.2 and 0.5mg/kg) decreased aggressive behavior in both A infant and adult rats. The desensitization of 5-HT1A receptors in the brain of A infant and adult rats was revealed. In contrast to decreased 5-HT1A gene expression in the midbrain of A adult rats, the 5-HT1A gene expression in the midbrain of infant rats did not differ between A and NA strains. There was no difference in 5-HT1A receptor density in infant rats. The data showed (1) the implication of 5-HT1A receptor in genetically defined infancy-onset fear-induced aggression, (2) the desensitization of 5-HT1A receptors as essential factor in infancy-onset aggression, and (3) the increased complexity of 5-HT-ergic control of aggressive behavior in adult rats with the involvement of 5-HT1A gene and the density of 5-HT1A receptors.
authors.affiliation: Department of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia. naumenko2002@bionet.nsc.ru
authors.forename: Vladimir S
authors.initials: VS
authors.lastname: Naumenko
authors.forename: Rimma V
authors.initials: RV
authors.lastname: Kozhemyakina
authors.forename: Irina F
authors.initials: IF
authors.lastname: Plyusnina
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kulikov
authors.forename: Nina K
authors.initials: NK
authors.lastname: Popova
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000008:administration & dosage / Q000494:pharmacology; D000374:Aggression / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D005239:Fear / Q000502:physiology; D051381:Rats; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism* / Q000502:physiology; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D017366:Serotonin Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin