title: Numerical simulation of the inhibitory effect of angiostatin on metastatic tumor angiogenesis and microenvironment.
abstract: The present work formulates and analyzes the inhibitory effect of anti-angiogenic factor angiostatin excreted by the primary tumor on metastatic tumor angiogenesis, blood perfusion, and interstitial fluid flow in the tumor microenvironment by means of a numerical experiment. The simulation results demonstrate that angiostatin has an obvious impact on the morphology, growth rate, and the number of branches of microvascular network inside and outside the metastatic tumor, and angiostatin has the capacity to regulate and inhibit the formation of new blood vessels. Heterogeneous blood perfusion, widespread interstitial hypertension, and low convection within the metastatic tumor have obviously improved under the inhibitory effect of angiostatin, which are consistent with physiological observed facts. The simulation results may provide beneficial information and theoretical models for clinical research of anti-angiogenic therapy strategies.
authors.affiliation: School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. zgp_06@yahoo.com.cn
authors.forename: Gaiping
authors.initials: G
authors.lastname: Zhao
authors.forename: Wentao
authors.initials: W
authors.lastname: Yan
authors.forename: Eryun
authors.initials: E
authors.lastname: Chen
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Yu
authors.forename: Wenjie
authors.initials: W
authors.lastname: Cai
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D043168:Angiostatins / Q000494:pharmacology* / Q000627:therapeutic use; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy
chemical_list: D020533:Angiogenesis Inhibitors; D043168:Angiostatins