title: Influence of hematoma location on acute mortality after intracerebral hemorrhage.
abstract: OBJECTIVE
  This study aimed to identify predictors of acute mortality after intracerebral hemorrhage (ICH), including voxel-wise analysis of hematoma location.
  
  
  METHODS
  In 282 consecutive patients with acute ICH, clinical and radiological predictors of acute mortality were identified. Voxel-based lesion-symptom mapping examined spatial correlates of acute mortality, contrasting results in basal ganglia ICH and lobar ICH.
  
  
  RESULTS
  Acute mortality was 47.9%. In bivariate analyses, one clinical (serum glucose) and two radiological (hematoma volume and intraventricular extension) measures significantly predicted mortality. The relationship was strongest for hematoma volume. Multivariable modeling identified four significant predictors of mortality (ICH volume, intraventricular extension, serum glucose, and serum hemoglobin), although this model only minimally improved the predictive value provided by ICH volume alone. Voxel-wise analysis found that for patients with lobar ICH, brain regions where acute hematoma was significantly associated with higher acute mortality included inferior parietal lobule and posterior insula; for patients with basal ganglia ICH, a large region extending from cortex to brainstem.
  
  
  CONCLUSIONS
  For patients with lobar ICH, acute mortality is related to both hematoma size and location, with findings potentially useful for therapeutic decision making. The current findings also underscore differences between the syndromes of acute deep and lobar ICH.
authors.affiliation: Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Ji-Yong
authors.initials: JY
authors.lastname: Lee
authors.forename: Caroline
authors.initials: C
authors.lastname: King
authors.forename: Dana
authors.initials: D
authors.lastname: Stradling
authors.forename: Michael
authors.initials: M
authors.lastname: Warren
authors.forename: Dennis
authors.initials: D
authors.lastname: Nguyen
authors.forename: Johnny
authors.initials: J
authors.lastname: Lee
authors.forename: Mark A
authors.initials: MA
authors.lastname: Riola
authors.forename: Ricardo
authors.initials: R
authors.lastname: Montoya
authors.forename: Dipika
authors.initials: D
authors.lastname: Patel
authors.forename: Vu H
authors.initials: VH
authors.lastname: Le
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Welbourne
authors.forename: Steven C
authors.initials: SC
authors.lastname: Cramer
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D002140:California / Q000453:epidemiology; D002533:Cerebral Angiography / Q000706:statistics & numerical data*; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging* / Q000401:mortality*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*
keywords: Intracerebral hemorrhage; acute; intraventricular hemorrhage; mortality