title: Renal replacement therapy with net fluid removal lowers intra-abdominal pressure and volumetric indices in critically ill patients.
abstract: BACKGROUND
  Little is known about the effects of renal replacement therapy (RRT) with fluid removal on intra-abdominal pressure (IAP). The global end-diastolic volume index (GEDVI) and extravascular lung water index (EVLWI) can easily be measured bedside by transpulmonary thermodilution (TPTD). The aim of this study is to evaluate the changes in IAP, GEDVI and EVLWI in critically ill patients receiving slow extended daily dialysis (SLEDD) or continuous venovenous haemofiltration (CVVH) with the intention of net fluid removal.
  
  
  METHODS
  We performed a retrospective cohort study in ICU patients who were treated with SLEDD or CVVH and in whom IAP was also measured, and RRT sessions were excluded when the dose of vasoactive medication needed to be changed between the pre- and post-dialysis TPTD measurements and when net fluid loss did not exceed 500 ml. The TPTD measurements were performed within 2 h before and after SLEDD; in case of CVVH, before and after an interval of 12 h.
  
  
  RESULTS
  We studied 25 consecutive dialysis sessions in nine patients with acute renal failure and cardiogenic or non-cardiogenic pulmonary oedema. The GEDVI and EVLWI values before dialysis were 877 ml/m² and 14 ml/kg, respectively. Average net ultrafiltration per session was 3.6 l, with a net fluid loss 1.9 l. The GEDVI decreased significantly during dialysis, but not more than 47.8 ml/m² (p = 0.008), as also did the EVLWI with 1 ml/kg (p = 0.03). The IAP decreased significantly from 12 to 10.5 mmHg (p < 0.0001).
  
  
  CONCLUSIONS
  Net fluid removal by SLEDD or CVVH in the range observed in this study decreased IAP, GEDVI and EVLWI in critically ill patients although EVLWI reduction was modest.
authors.affiliation: Department of Intensive Care, Ziekenhuisnetwerk Antwerpen (ZNA) Stuivenberg, Lange Beeldekensstraat 267, Antwerp, B-2060, Belgium. manu.malbrain@skynet.be.
authors.forename: Inneke
authors.initials: I
authors.lastname: De Laet
authors.forename: Dries
authors.initials: D
authors.lastname: Deeren
authors.forename: Karen
authors.initials: K
authors.lastname: Schoonheydt
authors.forename: Niels
authors.initials: N
authors.lastname: Van Regenmortel
authors.forename: Hilde
authors.initials: H
authors.lastname: Dits
authors.forename: Manu Lng
authors.initials: ML
authors.lastname: Malbrain