title: Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension.
abstract: Uric acid (UA) is independently associated with the emergence of hypertension. Nocturnal nondipping pattern of hypertension is associated with a greater risk of cardiovascular, renal, and cerebrovascular complications than dippers. The aim of the present study was to evaluate the relationship between the circadian blood pressure rhythm and UA level in patients with newly diagnosed essential hypertension. The study included 112 essential hypertensive patients and 50 healthy controls. The hypertensive patients were divided into two groups according to the results of 24-hour ambulatory blood pressure monitoring, including 60 dippers (35 men, 25 women; mean age, 52.6±15.8 years) and 52 nondippers (29 men, 23 women; mean age, 55.9±13.2 years). Nondippers had significantly higher serum UA levels than the dippers and controls (5.8±0.8, 5.1±0.9 and 4.2±0.9 mg/dL, respectively; P<.001). Serum high-sensitivity C-reactive protein levels were also significantly higher in the nondipper group than the other groups (P<.001) and significantly correlated with serum UA (r=0.358, P<.001). Multivariate logistic regression analysis revealed an independent positive association between serum UA levels and nondipper pattern (odds ratio, 2.28; 95% confidence interval, 1.33-3.94; P=.003). Serum UA is strongly and independently associated with the nondipper circadian pattern in essential hypertension.
authors.affiliation: Department of Cardiology, Türkiye Yüksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Turak
authors.forename: Fırat
authors.initials: F
authors.lastname: Ozcan
authors.forename: Derya
authors.initials: D
authors.lastname: Tok
authors.forename: Ahmet
authors.initials: A
authors.lastname: Işleyen
authors.forename: Erdoğan
authors.initials: E
authors.lastname: Sökmen
authors.forename: Irfan
authors.initials: I
authors.lastname: Taşoğlu
authors.forename: Sinan
authors.initials: S
authors.lastname: Aydoğdu
authors.forename: Nihat
authors.initials: N
authors.lastname: Sen
authors.forename: Kim
authors.initials: K
authors.lastname: McFann
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Johnson
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
mesh_terms: D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D018660:Blood Pressure Monitoring, Ambulatory; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D002097:C-Reactive Protein