title: Advanced research on risk factors of type 2 diabetes.
abstract: The prevalence of type 2 diabetes is increasing globally and poses a heavy burden on public health and socioeconomic development of all nations. Type 2 diabetes is a multifactorial disease and due to a combination of environmental and genetic risk factors. Many environmental risk factors contribute to the pathogenesis of type 2 diabetes, including lifestyles such as sedentary behaviour, diet, smoking and alcohol consumption, internal environmental factors such as inflammatory factors, adipocytokines and hepatocyte factors, external environmental factors such as environmental endocrine disruptors. This review summarizes current research efforts concentrated on the contributors for accelerated type 2 diabetes epidemic. It also provides a novel prospect for future researches.
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China.
authors.forename: Yufang
authors.initials: Y
authors.lastname: Bi
authors.forename: Tiange
authors.initials: T
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.forename: Mian
authors.initials: M
authors.lastname: Li
authors.forename: Jieli
authors.initials: J
authors.lastname: Lu
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhu
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000209:etiology*; D004032:Diet / Q000009:adverse effects; D006801:Humans; D015995:Prevalence; D012307:Risk Factors; D057185:Sedentary Behavior; D012907:Smoking / Q000009:adverse effects