title: [Melatonin as a regulator of metabolism].
abstract: High prevalence of metabolic syndrome (MS) necessitates elucidation of its causes. Disturbed melatonin synthesis is supposed to be one of them. This work was aimed at studying melatonin (M) secretion in MS and its influence on the main symptoms of MS. It was shown that melatonin production decreases at 4 a.m. and increases in the afternoon when it is correlated with waist circumference, insulin and LDLP levels (+0.28, -0.30, -0.44). M secretion in the morning correlates with blood glucose level and mean daily AP (-0.37, -0.22). Correlation of M secretion at 4 a.m., in the afternoon and at night with MS parameters was described by coefficients R equaling 0.79, 0.75 and 0.74 respectively. It is concluded that the intragroup risk of MS development is 2.9 and increases when M secretion is disturbed.
authors.forename: I S
authors.initials: IS
authors.lastname: Dzherieva
authors.forename: N I
authors.initials: NI
authors.lastname: Volkova
authors.forename: S I
authors.initials: SI
authors.lastname: Rapoport
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008550:Melatonin / Q000096:biosynthesis / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000209:etiology / Q000503:physiopathology*; D008875:Middle Aged; D012306:Risk; D013997:Time Factors; D055105:Waist Circumference / Q000502:physiology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008077:Lipoproteins, LDL; D008550:Melatonin