title: MR-less surface-based amyloid estimation by subject-specific atlas selection and Bayesian fusion.
abstract: For clinical evaluation, assessing amyloid deposition with PiB-PET is desirable without requiring MR acquisition and associated fusion/segmentation techniques. A useful clinical tool is to estimate PiB-PET against the brain surface, which is however challenging using PET alone because of the lack of structural information. We propose a method to generate such estimate, where multiple atlases are selected and combined with local weights in a Bayesian framework. Qualitative and quantitative comparison with and without MRI are presented. Using PET only, the average error on the brain surface was around 13% compared to MRI-dependant method.
authors.affiliation: Australian e-Health Research Centre, CSIRO, Australia.
authors.forename: Luping
authors.initials: L
authors.lastname: Zhou
authors.forename: Olivier
authors.initials: O
authors.lastname: Salvado
authors.forename: Vincent
authors.initials: V
authors.lastname: Dore
authors.forename: Pierrick
authors.initials: P
authors.lastname: Bourgeat
authors.forename: Parnesh
authors.initials: P
authors.lastname: Raniga
authors.forename: Victor L
authors.initials: VL
authors.lastname: Villemagne
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Rowe
authors.forename: Jurgen
authors.initials: J
authors.lastname: Fripp
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D058227:Amyloidogenic Proteins / Q000378:metabolism*; D000814:Aniline Compounds; D001499:Bayes Theorem; D052160:Benzothiazoles; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D010363:Pattern Recognition, Automated / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D058227:Amyloidogenic Proteins; D000814:Aniline Compounds; D052160:Benzothiazoles; D019275:Radiopharmaceuticals; D013844:Thiazoles