title: Thyrotoxic periodic paralysis with Graves' disease leading to the discovery of a hidden nonclassic 11β hydroxylase deficiency.
abstract: 11β hydroxylase deficiency (OHD) is one of the main causes of congenital adrenal hyperplasia. There have been only a few reported cases of nonclassic 11β OHD, a milder form of the disease. It is difficult to detect occult nonclassic 11β OHD because patients present with no or mild symptoms. We herein present a case of thyrotoxic periodic paralysis (TPP) with Graves' disease leading to the discovery of a hidden nonclassic 11β OHD. In this case, increased levels of thyroid hormone seem to have induced symptoms of occult nonclassic 11β OHD and aggravated TPP.
authors.affiliation: Department of Endocrinology and Metabolism, Chosun University Hospital, Republic of Korea.
authors.forename: Jin Hwa
authors.initials: JH
authors.lastname: Kim
authors.forename: Geon
authors.initials: G
authors.lastname: Park
authors.forename: Sang Yong
authors.initials: SY
authors.lastname: Kim
authors.forename: Hak Yeon
authors.initials: HY
authors.lastname: Bae
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006111:Graves Disease / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D020514:Hypokalemic Periodic Paralysis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D009154:Mutation; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011188:Potassium / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D018570:Risk Assessment; D012720:Severity of Illness Index; D013252:Steroid 11-beta-Hydroxylase / Q000235:genetics / Q000378:metabolism*; D013971:Thyrotoxicosis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D008713:Methimazole; D011433:Propranolol; D013252:Steroid 11-beta-Hydroxylase; D011188:Potassium