title: Differential Response to Methylphenidate in Inattentive and Combined Subtype ADHD.
abstract: To examine response to methylphenidate (MPH) assessed by direct observation of ecologically valid behaviors in boys with ADHD with high hyperactivity-impulsivity (HI) and those with predominantly inattentive symptoms (ADHD/I).
  
  
  
  Sixty-three boys ages 7 to 13 participated in an ADHD Summer Treatment Program and received a double-blind placebo-controlled assessment of .3 mg/kg of MPH on problem behaviors and individualized behavior goals. Medication effect sizes were calculated for each child for each behavior.
  
  
  
  Children with ADHD/HI ( n = 21) displayed larger MPH effect sizes for interrupting, verbal abuse, and compliance, and marginally greater response for teasing and counselor-directed goals. Children with ADHD/I ( n = 21) displayed small medication effect sizes ( ds < .20) for many behaviors often identified as primary deficits in this group (e.g., attention to activities, peer interaction, class work completion, and accuracy).
  
  
  
  Systematic medication assessment for ADHD/I that quantifies response in ecologically valid areas of functional impairment is essential.
authors.affiliation: 1 Lycoming College, Williamsport, PA, USA.
authors.forename: Susan H
authors.initials: SH
authors.lastname: Beery
authors.affiliation: 2 University of Miami, Coral Gables, FL, USA.
authors.forename: Herbert C
authors.initials: HC
authors.lastname: Quay
authors.affiliation: 3 Florida International University, Miami, FL, USA.
authors.forename: William E
authors.initials: WE
authors.lastname: Pelham
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001288:Attention / Q000187:drug effects; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D001521:Behavior Therapy / Q000379:methods; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D004311:Double-Blind Method; D006801:Humans; D007175:Impulsive Behavior / Q000187:drug effects; D007398:Interpersonal Relations; D008297:Male; D055118:Medication Adherence; D008774:Methylphenidate / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate
keywords: ADHD subtypes; medication treatment; methylphenidate