title: [Preliminary study of real-time three-dimensional dobutamine stress echocardiography for coronary artery disease assessment].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of real-time three-dimensional dobutamine stress echocardiography for coronary artery disease assessment.
  
  
  METHODS
  A total of 14 patients suspected of coronary artery disease (CAD) underwent real-time three-dimensional dobutamine stress echocardiography. The initial infusion rate of dobutamine was 5 µg×kg⁻¹ ×min⁻¹, followed by 10 µg×kg⁻¹×min⁻¹ and peak infusion 20 µg×kg⁻¹×min⁻¹ in 3 min stages. At baseline state, stress stages and after the study, the real-time three-dimensional (RT3D) images were captured and assessed by wall motion score index (WMSI) and regional ejection fraction (rEF). And the parameters of these two modalities versus coronary angiography (CAG) were compared and analyzed. Adverse reactions were also observed.
  
  
  RESULTS
  All patients completed the stress study uneventfully. As compared with CAG, these two modalities showed no significant difference (P > 0.05) and satisfactory agreement (κ values of 0.704 and 0.759 respectively). The diagnostic parameters of these modalities were: sensitivity (78% vs 89%), specificity (92% vs 88%), positive predictive value (PPV) (88% vs 84%), negative predictive value (NPV) (85% vs 91%) and overall accuracy (86% vs 88%).
  
  
  CONCLUSIONS
  Real-time three-dimensional dobutamine stress echocardiography is an effective, rapid and safe technique of assessing coronary artery disease. It is worthy of wider clinical applications.
authors.affiliation: Department of Cardiology, Hainan Branch of Chinese PLA General Hospital, Sanya 572000, China. yongxu301@163.com
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.forename: Jun-song
authors.initials: JS
authors.lastname: Liu
authors.forename: Guang
authors.initials: G
authors.lastname: Zhi
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Shu-lin
authors.initials: SL
authors.lastname: Ou
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhou
authors.forename: Guang-hui
authors.initials: GH
authors.lastname: Chen
mesh_terms: D000328:Adult; D017023:Coronary Angiography / Q000379:methods; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004280:Dobutamine; D025401:Echocardiography, Stress / Q000379:methods*; D019560:Echocardiography, Three-Dimensional; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity
chemical_list: D004280:Dobutamine