title: Cardenolide glycosides from root of Streptocaulon juventas.
abstract: Six cardenolides were isolated from the anti-tumor active fraction of the 75% ethanol extract of Streptocaulon juventas (Asclepiadaceae), mainly found in southwest of China. These were named 1α, 14β-dihydroxy-5β-card-20 (22)-enolide 3-O-[O-β-D-glucopyranosyl-(1→2)-β-D-digitalopyranoside] (1), acovenosigenin A 3-O-[O-β-D-glucopyranosyl-(1→4)-β-D-digitalopyranoside] (2), 16-O-acetyl-hydroxyperiplogenin 3-O-β-D-digitoxopyranoside (3), digitoxigenin 3-O-[O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl-(1→4)-2-O-acetyl-β-D-digitalopyranoside] (4), 16-O-acetyl-hydroxyacovenosigenin (5), 1β, 3β, 14β-trihydroxy-5β-card-16, 20 (22)-dienolide (6), together with 18 known ones, most of which had never been reported in the species beforehand. Their structures were elucidated on the basis of spectroscopic studies and comparison with reference. Eighteen compounds were evaluated for their cytotoxicity against human lung A549 adenocarcinoma cell lines.
authors.affiliation: Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xue
authors.forename: Na
authors.initials: N
authors.lastname: Han
authors.forename: Chun
authors.initials: C
authors.lastname: Ye
authors.forename: Hai-bo
authors.initials: HB
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002298:Cardenolides / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002298:Cardenolides; D006027:Glycosides; D004317:Doxorubicin