title: Oxidation of aromatic N-heterocyclic compounds to N-oxides by Verticillium sp. GF39 cells.
abstract: Verticillium sp. GF39, catalyzing the oxidation of 1-methylisoquinoline to 1-methylisoquinoline N-oxide, was found to be the highest N-oxide producer. Under the optimized reaction conditions, the whole cells of Verticillium sp. GF39 formed 5 mM 1-methylisoquinoline N-oxide from 1-methylisoquinoline with a molar conversion yield of 100% after a 10-h incubation at 20°C. The whole cells also acted on pyridine, 2-methylpyridine, quinoline and isoquinoline and formed the corresponding N-oxides.
authors.affiliation: Department of Biomolecular Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. mitukura@gifu-u.ac.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Mitsukura
authors.forename: Masafumi
authors.initials: M
authors.lastname: Hayashi
authors.forename: Toyokazu
authors.initials: T
authors.lastname: Yoshida
authors.forename: Toru
authors.initials: T
authors.lastname: Nagasawa
mesh_terms: D003497:Cyclic N-Oxides / Q000737:chemistry / Q000378:metabolism*; D007546:Isoquinolines / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D010847:Picolines / Q000378:metabolism; D011725:Pyridines / Q000378:metabolism; D020172:Verticillium / Q000737:chemistry / Q000378:metabolism*
chemical_list: D003497:Cyclic N-Oxides; D007546:Isoquinolines; D010847:Picolines; D011725:Pyridines; C530793:2-picoline; C023666:pyridine; C103464:1-methylisoquinoline