title: Vinylogous reactivity of enol diazoacetates with donor-acceptor substituted hydrazones. Synthesis of substituted pyrazole derivatives.
abstract: A regiospecific synthesis of multifunctional pyrazoleshas been developed from a cascade process triggered by Rh(II)-catalyzed dinitrogen extrusion from enol diazoacetates with vinylogous nucleophilic addition followed by Lewis acid catalyzed cyclization and aromatization.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
authors.forename: Xinfang
authors.initials: X
authors.lastname: Xu
authors.forename: Peter Y
authors.initials: PY
authors.lastname: Zavalij
authors.forename: Wenhao
authors.initials: W
authors.lastname: Hu
authors.forename: Michael P
authors.initials: MP
authors.lastname: Doyle
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006835:Hydrazones / Q000737:chemistry*; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001391:Azo Compounds; D006835:Hydrazones; D011720:Pyrazoles; C031280:pyrazole