title: Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10.
abstract: Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).
authors.affiliation: Animal Genomics Laboratory, School of Agriculture and Food Science, University College Dublin, Dublin, Ireland; Section of Veterinary Clinical Sciences, School of Veterinary Medicine, University College Dublin, Dublin, Ireland.
authors.forename: N
authors.initials: N
authors.lastname: Orr
authors.forename: E W
authors.initials: EW
authors.lastname: Hill
authors.forename: J
authors.initials: J
authors.lastname: Gu
authors.forename: P
authors.initials: P
authors.lastname: Govindarajan
authors.forename: J
authors.initials: J
authors.lastname: Conroy
authors.forename: E M
authors.initials: EM
authors.lastname: van Grevenhof
authors.forename: B J
authors.initials: BJ
authors.lastname: Ducro
authors.forename: J A M
authors.initials: JA
authors.lastname: van Arendonk
authors.forename: J H
authors.initials: JH
authors.lastname: Knaap
authors.forename: P R
authors.initials: PR
authors.lastname: van Weeren
authors.forename: D E
authors.initials: DE
authors.lastname: Machugh
authors.forename: S
authors.initials: S
authors.lastname: Ennis
authors.forename: P A J
authors.initials: PA
authors.lastname: Brama
mesh_terms: D000818:Animals; D001947:Breeding; D002874:Chromosome Mapping / Q000662:veterinary; D033481:Chromosomes, Mammalian / Q000235:genetics*; D005260:Female; D056426:Genetic Loci / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods / Q000662:veterinary*; D005838:Genotype; D006239:Haplotypes; D006734:Horse Diseases / Q000000981:diagnostic imaging / Q000235:genetics*; D006736:Horses; D007592:Joint Diseases / Q000000981:diagnostic imaging / Q000235:genetics / Q000662:veterinary*; D008297:Male; D055034:Osteochondrosis / Q000000981:diagnostic imaging / Q000235:genetics / Q000662:veterinary*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011859:Radiography
keywords: Equus caballus; Orthopaedic disease; SNP