title: Computational modeling of epidermal cell fate determination systems.
abstract: Cell fate decisions are of primary importance for plant development. Their simple 'either-or' outcome and dynamic nature has attracted the attention of computational modelers. Recent efforts have focused on modeling the determination of several epidermal cell types in the root and shoot of Arabidopsis where many molecular components have been defined. Results of integrated modeling and molecular biology experimentation in these systems have highlighted the importance of competitive positive and negative factors and interconnected feedback loops in generating flexible yet robust mechanisms for establishing distinct gene expression programs in neighboring cells. These models have proven useful in judging hypotheses and guiding future research.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109, USA.
authors.forename: Kook Hui
authors.initials: KH
authors.lastname: Ryu
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Zheng
authors.forename: Ling
authors.initials: L
authors.lastname: Huang
authors.forename: John
authors.initials: J
authors.lastname: Schiefelbein
mesh_terms: D017360:Arabidopsis / Q000166:cytology / Q000235:genetics / Q000254:growth & development*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D019521:Body Patterning; D002454:Cell Differentiation; D003198:Computer Simulation; D005246:Feedback; D018507:Gene Expression Regulation, Developmental; D018506:Gene Expression Regulation, Plant; D008954:Models, Biological; D019441:Plant Epidermis / Q000166:cytology / Q000235:genetics / Q000254:growth & development*; D018517:Plant Roots / Q000166:cytology / Q000235:genetics / Q000254:growth & development; D018547:Plant Stems / Q000166:cytology / Q000235:genetics / Q000254:growth & development; D054046:Plant Stomata / Q000166:cytology / Q000235:genetics / Q000254:growth & development
chemical_list: D029681:Arabidopsis Proteins