title: Salivary lncRNA as a potential marker for oral squamous cell carcinoma             diagnosis.
abstract: Oral squamous cell carcinoma (OSCC) is a common and lethal malignancy. Thus,             improvement in current knowledge of molecular changes associated with OSCC is             urgently needed to explore novel avenues of diagnostics and treatment of this             disease. While aberrant expression of long non‑coding RNAs (lncRNAs) has been             functionally associated with certain types of cancer, including lung, breast and             prostate carcinomas, their expression pattern and biological relevance in OSCC             is currently unknown. In the present study, the relative abundance of a collection             of lncRNAs in tissue or saliva samples from OSCC patients was investigated. It             was shown that subsets of lncRNAs are expressed across non‑tumor, tumor and metastatic             tissue samples. Some detected lncRNAs were shown to be aberrantly expressed in             cases of oral cancer and metastasis. Moreover, whole saliva contained a detectable             amount of some lncRNAs, which appeared to be potential markers for OSCC. These             findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive             and rapid diagnostic tool for the diagnosis of oral cancer.
authors.affiliation: Department of Oral and Maxicallifacial Surgery, The Affiliated Stomatology Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510055, PR China.
authors.forename: Haikuo
authors.initials: H
authors.lastname: Tang
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Wu
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Su
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D012463:Saliva / Q000378:metabolism*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding