title: [Radiation-induced modification of human somatic cell chromosome sensitivity to the testing mutagenic exposure of bleomycin in vitro in lung cancer patients in delayed terms following Chernobyl accident].
abstract: By using modified "G2-bleomycin sensitivity assay" above background level of cytogenetic effect considered as a marker of hidden chromosome instability (HCI) has been investigated in 3 groups--liquidators of Chernobyl accident (occupational group 1), patients with lung cancer who denied conscious contact--with ionizing radiation (group of comparison), liquidators with lung cancer (occupational group 2). Significant interindividual variations of cytogenetic effects induced with bleomycin and the lack of positive correlation between background and above background frequencies of chromosome aberrations have been shown in all observed groups. It had been established that occupational group 2 was the most burdened group by expression of the above background cytogenetic effect and, accordingly, number of persons with HCI. The data obtained permit to suggest the existence of the association between radiation-induced increase of individual sensitivity to testing mutagenic exposure and the realization of cancer in persons exposed to ionizing radiation. The results show acceptability of "G2-bleomycin sensitivity assay" under the cytogenetic examination of irradiated contingents for determining HCI as one of informative markers of predisposition to oncopathology.
authors.forename: M A
authors.initials: MA
authors.lastname: Pilinskaia
authors.forename: S S
authors.initials: SS
authors.lastname: Dybskiĭ
authors.forename: E B
authors.initials: EB
authors.lastname: Dybskaia
authors.forename: L I
authors.initials: LI
authors.lastname: Shvaĭko
mesh_terms: D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000494:pharmacology*; D016022:Case-Control Studies; D002478:Cells, Cultured; D047852:Chernobyl Nuclear Accident; D043171:Chromosomal Instability / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects*; D020732:Cytogenetic Analysis; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000494:pharmacology*; D009381:Neoplasms, Radiation-Induced / Q000235:genetics* / Q000473:pathology; D009784:Occupational Diseases / Q000235:genetics* / Q000473:pathology; D012303:Ring Chromosomes; D013997:Time Factors; D055815:Young Adult
chemical_list: D009153:Mutagens; D001761:Bleomycin