title: Targeting DNA damage response: threshold, chromatin landscape and beyond.
abstract: Cells are continually exposed to DNA assaults from exogenous and endogenous sources. To maintain genomic integrity, cells have evolved a highly conserved mechanism for repairing DNA lesions and, in particular, DNA double strand breaks (DSBs). Emerging evidence indicates that DNA repair/signaling machinery acts in an integrated fashion with chromatin structure at damaged sites. This review focuses on the interplay between histone modifications and the chromatin-mediated response to DNA damage.
authors.affiliation: Department of Biology, University of Rome Tor Vergata, via della Ricerca Scientifica, I-00133 Rome, Italy. Stefania.Gonfloni@uniroma2.it
authors.forename: Stefania
authors.initials: S
authors.lastname: Gonfloni
mesh_terms: D002843:Chromatin / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D006657:Histones / Q000378:metabolism
chemical_list: D002843:Chromatin; D006657:Histones