title: MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment.
abstract: The management of cardiovascular risk through lifestyle modification and pharmacotherapy is paramount to the prevention of cardiovascular disease. Epidemiological studies have identified obesity, dyslipidemia, diabetes, and hypertension as interrelated factors that negatively affect cardiovascular health. Recently, genetic and pharmacological evidence in model systems has implicated microRNAs as dynamic modifiers of disease pathogenesis. An expanded understanding of the function of microRNAs in gene regulatory networks associated with cardiovascular risk will enable identification of novel genetic mechanisms of disease and inform the development of innovative therapeutic strategies.
authors.affiliation: Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Quiat
authors.forename: Eric N
authors.initials: EN
authors.lastname: Olson
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy*; D048909:Diabetes Complications / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D050171:Dyslipidemias / Q000150:complications / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D012307:Risk Factors
chemical_list: D035683:MicroRNAs