title: Fluorous supported modular synthesis of heparan sulfate oligosaccharides.
abstract: The modular synthesis of heparan sulfate fragments is greatly facilitated by employing an anomeric aminopentyl linker protected by a benzyloxycarbonyl group modified by a perfluorodecyl tag, which made it possible to purify highly polar intermediates by fluorous solid phase extraction. This tagging methodology made it also possible to perform repeated glycosylations to drive reactions to completion.
authors.affiliation: Complex Carbohydrate Research Center, The University of Georgia, 315 Riverbend Road, Athens, Georgia 30602, USA.
authors.forename: Chengli
authors.initials: C
authors.lastname: Zong
authors.forename: Andre
authors.initials: A
authors.lastname: Venot
authors.forename: Omkar
authors.initials: O
authors.lastname: Dhamale
authors.forename: Geert-Jan
authors.initials: GJ
authors.lastname: Boons
mesh_terms: D006031:Glycosylation; D006497:Heparan Sulfate / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D052616:Solid Phase Extraction
chemical_list: D006497:Heparan Sulfate; D007202:Indicators and Reagents; D009844:Oligosaccharides