title: Association between history of abortion and nonalcoholic fatty liver disease in middle-aged and elderly Chinese women.
abstract: OBJECTIVE
  To evaluate the possible relationship between self-reported history of abortion and nonalcoholic fatty liver disease (NAFLD) in middle-aged and elderly Chinese women.
  
  
  METHODS
  A cross-sectional study was performed in 5911 women aged 40 years or older in Jiading District, Shanghai, China. Reproductive histories, including miscarriage and induced abortion, were collected using a validated questionnaire by trained physicians. Abdominal B-mode ultrasound evaluation and serum liver enzymes levels were used in the diagnosis of NAFLD.
  
  
  RESULTS
  The percentage reporting history of abortion in women with NAFLD was higher than in those without NAFLD (72.4% vs. 69.3%, age-adjusted P = .001). Compared with women without a history of abortion, the fully adjusted odds ratio (OR) for NAFLD in those with a history of abortion was increased by 28% (OR, 1.28 and 95% confidence interval [CI], 1.06-1.55). Histories of miscarriage and induced abortion were also associated with increased risk of prevalent NAFLD in fully adjusted models (OR, 1.84 and 95% CI, 1.24-2.72; OR, 1.23 and 95% CI, 1.02-1.50, respectively).
  
  
  CONCLUSIONS
  Both miscarriage and induced abortion are associated with prevalent NAFLD in middle-aged and elderly Chinese women.
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Jieli
authors.initials: J
authors.lastname: Lu
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.forename: Mian
authors.initials: M
authors.lastname: Li
authors.forename: Tiange
authors.initials: T
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Baihui
authors.initials: B
authors.lastname: Xu
authors.forename: Jichao
authors.initials: J
authors.lastname: Sun
authors.forename: Meng
authors.initials: M
authors.lastname: Dai
authors.forename: Yufang
authors.initials: Y
authors.lastname: Bi
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
mesh_terms: D000028:Abortion, Induced / Q000706:statistics & numerical data*; D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D015984:Causality; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D011159:Population Surveillance; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires