title: Cine-ASL: a steady-pulsed arterial spin labeling method for myocardial perfusion mapping in mice. Part II. Theoretical model and sensitivity optimization.
abstract: In small rodent myocardial perfusion studies, the most widely used method is based on Look-Locker measurements of the magnetization recovery after FAIR preparation, which bears limitations regarding acquisition efficiency due to the pulsed arterial spin labeling nature of the sequence. To improve efficiency, this two-article set proposes a new steady-pulsed arterial spin labeling scheme using a cine readout incorporating one tagging pulse per heart cycle. In this part, we derive a theoretical description of the magnetization time evolution in such a scheme. The combination of steady-pulsed labeling and cine readout drives tissue magnetization into a stationary regime that explicitly depends on perfusion. In comparison with dedicated experiments on the mouse heart, the model is discussed and validated for perfusion quantification. The model predicts that in this regime, signal is independent of irregular dynamics occurring during acquisition, such as heart rate variations or arterial input function. Optimization of the sequence offers the possibility to increase the signal to noise ratio by efficient signal averaging. The sensitivity of this new method is shown to be more than three times larger than previously used techniques.
authors.affiliation: Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS N°7339, Faculté de Médecine, Aix-Marseille Université, Marseille, France.
authors.forename: Thibaut
authors.initials: T
authors.lastname: Capron
authors.forename: Thomas
authors.initials: T
authors.lastname: Troalen
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Cozzone
authors.forename: Monique
authors.initials: M
authors.lastname: Bernard
authors.forename: Frank
authors.initials: F
authors.lastname: Kober
mesh_terms: D000465:Algorithms; D000818:Animals; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D003198:Computer Simulation; D003326:Coronary Circulation / Q000502:physiology*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D008955:Models, Cardiovascular; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D013113:Spin Labels
chemical_list: D013113:Spin Labels
keywords: arterial spin labeling; blood flow; heart; mouse; myocardial perfusion; pseudo-continuous; steady-state