title: Parallel processing of environmental recognition and locomotion in the mouse striatum.
abstract: Information processing in behaving animals has been the target of many studies in the striatum; however, its dynamics and complexity remain to a large extent unknown. Here, we chronically recorded neuronal populations in dorsal striatum as mice were exposed to a novel environment, a paradigm which enables the dissociation of locomotion and environmental recognition. The findings indicate that non-overlapping populations of striatal projection neurons-the medium spiny neurons-reliably encode locomotion and environmental identity, whereas two subpopulations of short-spike interneurons encode distinct information: the fast spiking interneurons preferentially encode locomotion whereas the second type of interneurons preferentially encodes environmental identity. The three neuronal subgroups used cell-type specific coding schemes. This study provides evidence for the existence of parallel processing circuits within the sensorimotor region of the striatum.
authors.affiliation: Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel.
authors.forename: Hagar G
authors.initials: HG
authors.lastname: Yamin
authors.forename: Edward A
authors.initials: EA
authors.lastname: Stern
authors.forename: Dana
authors.initials: D
authors.lastname: Cohen
mesh_terms: D000465:Algorithms; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003627:Data Interpretation, Statistical; D004567:Electrodes, Implanted; D055724:Electrophysiological Phenomena; D004777:Environment; D005260:Female; D007395:Interneurons / Q000502:physiology; D016018:Least-Squares Analysis; D008124:Locomotion / Q000502:physiology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D017072:Neostriatum / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000145:classification / Q000502:physiology / Q000648:ultrastructure; D016012:Poisson Distribution; D021641:Recognition, Psychology / Q000502:physiology*; D060388:Support Vector Machine