title: A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation.
abstract: BACKGROUND
  Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF.
  
  
  RESULTS
  We included 178 young patients with lone AF and the first episode before the age of 40 years, and a control group of 875 healthy individuals. We analyzed a promoter SNP (-131CG) (rs4950928) in the Chitinase 3-like 1 (CHI3L1) gene encoding YKL-40, which had previously been associated with elevated levels of YKL-40.
  
  
  CONCLUSIONS
  The (-131CG) genotype was not associated with increased risk of AF. Genetically increased YKL-40 levels were not associated to AF.
authors.affiliation: Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. kristofferh@dadlnet.dk
authors.forename: Kristoffer M A
authors.initials: KM
authors.lastname: Henningsen
authors.forename: Morten S
authors.initials: MS
authors.lastname: Olesen
authors.forename: Golnaz
authors.initials: G
authors.lastname: Sajadieh
authors.forename: Stig
authors.initials: S
authors.lastname: Haunsoe
authors.forename: Jesper H
authors.initials: JH
authors.lastname: Svendsen
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D017668:Age of Onset; D001281:Atrial Fibrillation / Q000235:genetics*; D016022:Case-Control Studies; D000071451:Chitinase-3-Like Protein 1; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D054392:Adipokines; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins