title: Interleukin-2 determinations for monitoring the renal allograft.
abstract: Our results show that worsening of renal function dependent on cyclosporin, or caused by acute renal insufficiency of postrenal origin, can be distinguished from viral infection and rejection reactions by the determination of interleukin-2 (IL-2) in plasma, which functions as an early indicator or follow-up parameter. A definite differentiation between steroid-sensitive rejection reactions and virus infection does not yet seem to be possible by interleukin-2 determination.
authors.affiliation: Abt. für Klin. Hämostaseologie und Transfusionsmedizin der Unikliniken Homburg, Saar.
authors.forename: U T
authors.initials: UT
authors.lastname: Seyfert
authors.forename: W
authors.initials: W
authors.lastname: Gumbel
authors.forename: H
authors.initials: H
authors.lastname: Berger
authors.forename: U
authors.initials: U
authors.lastname: Schmidt
authors.forename: F W
authors.initials: FW
authors.lastname: Albert
mesh_terms: D058186:Acute Kidney Injury; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006084:Graft Rejection / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D007376:Interleukin-2 / Q000097:blood*; D007668:Kidney / Q000503:physiopathology; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D014777:Virus Diseases / Q000175:diagnosis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D016572:Cyclosporine