title: Role of nitric oxide-detoxifying enzymes in the virulence of Pseudomonas aeruginosa against the silkworm, Bombyx mori.
abstract: Pseudomonas aeruginosa has two nitric oxide (NO)-detoxification enzymes, NO reductase and flavohemoglobin, which catalyze the reduction and oxygenation of NO respectively. In this study, the NO reductase-deficient mutant showed decreased virulence against the silkworm Bombyx mori, but the flavohemoglobin-deficient mutant did not, indicating that NO-reduction is important to the full virulence of P. aeruginosa against B. mori.
authors.affiliation: Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan. aharai@mail.ecc.u-tokyo.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Iiyama
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D012831:Bombyx / Q000276:immunology / Q000382:microbiology*; D015964:Gene Expression Regulation, Bacterial; D006420:Hemeproteins / Q000235:genetics / Q000378:metabolism; D007814:Larva / Q000276:immunology / Q000382:microbiology*; D009569:Nitric Oxide / Q000378:metabolism*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000201:enzymology* / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D006420:Hemeproteins; C086193:flavohemoprotein, Bacteria; D009569:Nitric Oxide; D010088:Oxidoreductases; C034747:nitric-oxide reductase