title: The seed and the soil: optimizing stem cells and their environment for tissue regeneration.
abstract: The potential for stem cells to serve as cellular building blocks for reconstruction of complex defects has prompted significant enthusiasm in the field of regenerative medicine. Clinical application, however, is still limited, as implantation of cells into hostile wound environments may greatly hinder their tissue forming capacity. To circumvent this obstacle, novel approaches have been developed to manipulate both the stem cell itself and its surrounding environmental niche. By understanding this paradigm of seed and soil optimization, innovative strategies may thus be developed to harness the true promise of stem cells for tissue regeneration.
authors.affiliation: Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Jeong S
authors.initials: JS
authors.lastname: Hyun
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Montoro
authors.forename: David D
authors.initials: DD
authors.lastname: Lo
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Flynn
authors.forename: Victor
authors.initials: V
authors.lastname: Wong
authors.forename: Michael Thomas
authors.initials: MT
authors.lastname: Chung
authors.forename: Michael T
authors.initials: MT
authors.lastname: Longaker
authors.forename: Derrick C
authors.initials: DC
authors.lastname: Wan
mesh_terms: D002470:Cell Survival; D006801:Humans; D018919:Neovascularization, Physiologic; D012038:Regeneration / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*; D023822:Tissue Engineering; D054457:Tissue Scaffolds