title: Statins and the risk of interstitial lung disease: a cohort study.
abstract: BACKGROUND
  Case reports have suggested that the use of statins may be associated with an increase in the risk of interstitial lung disease (ILD).
  
  
  METHODS
  Within a large cohort of users of respiratory medications identified in the Quebec health administrative databases during 1990-2005, we carried out a nested case-control analysis of the relationship between statins and the risk of ILD as defined by specialist visits or hospitalisations.
  
  
  RESULTS
  The cohort included over 1.4 million patients, of which 6665 possible or probable cases of ILD were identified during follow-up. These were compared with 26 660 controls matched for age, gender and calendar time. After adjustment for confounders and comorbid conditions, there was no association between current use of statins and risk of ILD (adjusted OR 0.99, 95% CI 0.91 to 1.08). The results were similar when any use of statins within the previous 1 or 2 years was considered or when the analysis was limited to more definite cases.
  
  
  CONCLUSIONS
  This large cohort study did not find an association between statin use and the incidence of ILD.
authors.affiliation: Pulmonary Division, Jewish General Hospital, Montreal, Quebec, Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Saad
authors.forename: Philippe
authors.initials: P
authors.lastname: Camus
authors.forename: Samy
authors.initials: S
authors.lastname: Suissa
authors.forename: Pierre
authors.initials: P
authors.lastname: Ernst
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D015994:Incidence; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors