title: A definite case of (L)-carbocisteine-induced pneumonia with CATCH22 syndrome.
abstract: A 32-year-old male with CATCH22 syndrome presented with a high fever and productive cough after taking drugs for acute bronchitis, including (L)-carbocisteine. Chest radiography revealed ground-glass opacities in the bilateral lung fields. He had a history of similar pneumonia. Under the assumption of drug-induced pneumonia, or bacterial or viral pneumonia, all drugs including (L)-carbocisteine were discontinued, and antibiotics were started. A drug-induced lymphocyte stimulation test was positive only for (L)-carbocisteine. The only drug in common between this and the previous episode of pneumonia was (L)-carbocisteine. We thus concluded that this was a definite case of (L)-carbocisteine-induced pneumonia in a patient with CATCH22 syndrome.
authors.affiliation: Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan. kudoken19800411@yahoo.co.jp
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Kudo
authors.forename: Eiki
authors.initials: E
authors.lastname: Ichihara
authors.forename: Akiko
authors.initials: A
authors.lastname: Hisamoto
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Hotta
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Miyahara
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tanimoto
authors.forename: Sadaharu
authors.initials: S
authors.lastname: Akagi
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kato
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kiura
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002233:Carbocysteine / Q000009:adverse effects* / Q000627:therapeutic use; D003371:Cough / Q000188:drug therapy / Q000503:physiopathology; D004062:DiGeorge Syndrome / Q000150:complications* / Q000175:diagnosis; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000503:physiopathology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011014:Pneumonia / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy*; D013902:Radiography, Thoracic / Q000379:methods; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002233:Carbocysteine