title: The absence of M1 leads to increased establishment of murine gammaherpesvirus 68 latency in IgD-negative B cells.
abstract: The secreted M1 protein of murine gammaherpesvirus 68 (MHV68) promotes effector Vβ4(+) CD8(+) T cell expansion to impact virus control and immune-mediated pathologies in C57BL/6 mice, but not BALB/c mice. We report a striking increase in the number of genome-positive, IgD(-) B cells during chronic infection of both mouse strains. This suggests a novel role for M1 in influencing long-term maintenance in a major latency reservoir irrespective of the degree of Vβ4(+) CD8(+) T cell expansion.
authors.affiliation: Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA. laurie.krug@stonybrook.edu
authors.forename: Laurie T
authors.initials: LT
authors.lastname: Krug
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Evans
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Gargano
authors.forename: Clinton R
authors.initials: CR
authors.lastname: Paden
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Speck
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology*; D007072:Immunoglobulin D / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018144:Rhadinovirus / Q000276:immunology* / Q000472:pathogenicity*; D014764:Viral Proteins / Q000276:immunology / Q000378:metabolism*; D017735:Virus Latency
chemical_list: D007072:Immunoglobulin D; D014764:Viral Proteins