title: What is the optimal mode of mechanical support in transplanted patients with acute graft failure?
abstract: A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: is extracorporeal membrane oxygenation (ECMO) superior to dedicated ventricular assist device (VAD) in patients with acutely failing allograft following transplantation. Altogether, 162 papers were found using the reported search, of which 8 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Two studies provide data only for ECMO-treated patients, in three, the authors describe their experiences with Levitronix CentriMag and three studies directly compare the outcomes of ECMO and VAD support. The survival ranges from 40 to 74% in patients rescued with ECMO compared with 33-60% in patients supported with dedicated VAD. We conclude that there is insufficient evidence to prefer ECMO over VAD and the optimal modality of mechanical circulatory support (MCS) following heart transplantation should be determined by the surgeon and institutional experience and dependent on the extent and severity of myocardial dysfunction and the presence or absence of associated respiratory insufficiency.
authors.affiliation: Department of Cardiac Surgery, Institute for Clinical and Experimental Medicine, Videnska, Prague, Czech Republic. maub@ikem.cz
authors.forename: Marian
authors.initials: M
authors.lastname: Urban
authors.forename: Ondrej
authors.initials: O
authors.lastname: Szarszoi
authors.forename: Jan
authors.initials: J
authors.lastname: Pirk
authors.forename: Ivan
authors.initials: I
authors.lastname: Netuka
mesh_terms: D019985:Benchmarking; D019317:Evidence-Based Medicine; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects / Q000401:mortality; D016027:Heart Transplantation / Q000009:adverse effects* / Q000401:mortality; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D012131:Respiratory Insufficiency / Q000209:etiology; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D018754:Ventricular Dysfunction / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right