title: Poikilodermatous mycosis fungoides.
abstract: Poikilodermatous mycosis fungoides (MF) is a variant of MF, formerly referred to as poikiloderma vasculare atrophicans. The lesions are classically characterized by large plaques of hypopigmentation and hyperpigmentation with atrophy and telangiectases. The plaques may be asymptomatic or mildly pruritic and typically involve the major flexural areas and trunk. Poikilodermatous MF has an early stage (IA-IIA) at diagnosis and a male predominance. Poikilodermatous MF shows an atypical T-cell infiltrate in the papillary dermis with evidence of epidermotropism, epidermal atrophy, dilated blood vessels in the dermis, melanophages, and melanin incontinence. Recent studies suggest a predominance of a CD8+, CD4- immunophenotype. Treatment modalities are similar to classic MF with phototherapy being the most common first-line therapy. Poikilodermatous MF has an excellent prognosis.
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.
authors.forename: Bradley
authors.initials: B
authors.lastname: Bloom
authors.forename: Shari
authors.initials: S
authors.lastname: Marchbein
authors.forename: Max
authors.initials: M
authors.lastname: Fischer
authors.forename: Hideko
authors.initials: H
authors.lastname: Kamino
authors.forename: Rishi
authors.initials: R
authors.lastname: Patel
authors.forename: Jo-Ann
authors.initials: JA
authors.lastname: Latkowski
mesh_terms: D004890:Erythema / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008214:Lymphocytes / Q000473:pathology; D009182:Mycosis Fungoides / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D013684:Telangiectasis / Q000209:etiology / Q000473:pathology; D055815:Young Adult
chemical_list: D007770:L-Lactate Dehydrogenase