title: Chronic inflammatory demyelinating polyradiculoneuropathy in a patient with Crohn's disease.
abstract: Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract that is frequently accompanied by systemic complications. Neuropathologies have not been well investigated as extraintestinal manifestations of CD. We herein report the case of a 36-year-old man with CD who presented with progressive weakness and numbness. A neurological examination and the results of a nerve conduction study and a sural nerve biopsy led to a diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Plasma exchanges were initially effective; however, the effects gradually declined starting 10 days after the plasma exchange (PE). These results suggest that humoral factors may play an important role in CIDP associated with CD.
authors.affiliation: Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan. ohyanuro@tmd.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Ohyagi
authors.forename: Takuya
authors.initials: T
authors.lastname: Ohkubo
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Yagi
authors.forename: Satoru
authors.initials: S
authors.lastname: Ishibashi
authors.forename: Junko
authors.initials: J
authors.lastname: Akiyama
authors.forename: Masakazu
authors.initials: M
authors.lastname: Nagahori
authors.forename: Mamoru
authors.initials: M
authors.lastname: Watanabe
authors.forename: Takanori
authors.initials: T
authors.lastname: Yokota
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Mizusawa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D004576:Electromyography / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D010951:Plasma Exchange / Q000379:methods*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D018570:Risk Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones