title: Antifungal prophylaxis in the haematological patient: a practical approach.
abstract: Antifungal prophylaxis in the haematological patient is currently regarded as the gold standard in situations with a high risk of infection, such as acute leukaemias, myelodysplastic syndromes and autologous or allogenic hematopoietic stem cell transplantation. Over the years, different scientific societies have established a series of recommendations on antifungal prophylaxis based on prospective studies performed with different drugs. However, the prescription of each one of the agents must be personalised, adapted to the characteristics of each patient and to possible interactions with concomitant medication.
authors.affiliation: Hospital Clínico Universitario Salamanca, Spain. lvazlo@usal.es
authors.forename: Lourdes
authors.initials: L
authors.lastname: Vázquez
authors.forename: Enric
authors.initials: E
authors.lastname: Carreras
authors.forename: David
authors.initials: D
authors.lastname: Serrano
authors.forename: Isidro
authors.initials: I
authors.lastname: Jarque
authors.forename: José
authors.initials: J
authors.lastname: Mensa
authors.forename: José
authors.initials: J
authors.lastname: Barberán
mesh_terms: D000465:Algorithms; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D001682:Biological Availability; D003663:Decision Trees; D004347:Drug Interactions; D054714:Echinocandins / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000150:complications* / Q000188:drug therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D008107:Liver Diseases / Q000150:complications; D009181:Mycoses / Q000209:etiology / Q000517:prevention & control*; D009190:Myelodysplastic Syndromes / Q000150:complications*; D011183:Postoperative Complications / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*; D017410:Practice Guidelines as Topic; D011292:Premedication; D014230:Triazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D054714:Echinocandins; D007166:Immunosuppressive Agents; D014230:Triazoles; C068538:liposomal amphotericin B; D000666:Amphotericin B