title: [Failure of cotrimoxazole prophylaxis for Pneumocystis jiroveci pneumonia with concomitant use of leucovorin: Case report].
abstract: The concomitant use of leucovorin and cotrimoxazole in PCP can lead to therapeutic failure and increased risk of death due to antagonism. It is important to keep this possible antagonistic interaction in mind even during prophylaxis. This paper presents a case with this failure outcome.
authors.affiliation: Unidad de Infectología, Hospital San Borja Arriarán, Chile. macabonacic@yahoo.com
authors.forename: Macarena
authors.initials: M
authors.lastname: Bonacic
authors.forename: Alfredo
authors.initials: A
authors.lastname: Silva
authors.forename: Marcelo
authors.initials: M
authors.lastname: Wolff
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage*; D008297:Male; D045363:Pneumocystis carinii; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D017211:Treatment Failure; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage*; D014803:Vitamin B Complex / Q000008:administration & dosage*
chemical_list: D000890:Anti-Infective Agents; D014803:Vitamin B Complex; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002955:Leucovorin