title: Giant condyloma of the cervix: an uncommon entity associated with low-risk human papilloma virus infection.
abstract: "Giant Condylomas" of the cervix are very uncommon, and have not been fully characterized in the English literature. We report 4 cases of cervical giant condyloma seen in our practice. Patients were predominantly young and presented with a cervical lesion producing bleeding or a mass effect. Biopsy/excision revealed a uniformly bland, exophytic squamous epithelial proliferation with viral cytopathic changes and absence of stromal invasion. Human papilloma virus types 6 and 11 were detected in all cases. Follow-up was uneventful without recurrence or spread. Giant condylomas of the cervix as defined in this report signify a benign albeit extensive variant of low-risk human papilloma virus infection. This term is proposed as a specific descriptor for such lesions and should be considered in the setting of any large well-differentiated exophytic cervical squamous lesion in young or immunosuppressed women. The term "giant condyloma of Buschke and Loewenstein" should be discontinued given the lack of specificity.
authors.affiliation: Department of Pathology, Women's and Perinatal Pathology Division, Brigham and Women's Hospital-Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Carlos
authors.initials: C
authors.lastname: Parra-Herran
authors.forename: Michael
authors.initials: M
authors.lastname: Herfs
authors.forename: Manuel
authors.initials: M
authors.lastname: Doria
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Crum
authors.forename: Marisa R
authors.initials: MR
authors.lastname: Nucci
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D062688:Buschke-Lowenstein Tumor / Q000473:pathology* / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D052140:Human papillomavirus 11 / Q000302:isolation & purification; D052163:Human papillomavirus 6 / Q000302:isolation & purification; D006801:Humans; D008279:Magnetic Resonance Imaging; D008679:Metaplasia / Q000175:diagnosis; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D017697:Premenopause; D002577:Uterine Cervical Diseases / Q000175:diagnosis; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000821:virology