title: Group-wise consistent parcellation of gyri via adaptive multi-view spectral clustering of fiber shapes.
abstract: In-vivo parcellation of the cerebral cortex via non-invasive neuroimaging data has been in active research for years. A variety of model-driven and/or data-driven computational approaches have been proposed to parcellate the cortex. However, two fundamental common issues in these parcellation methodologies are the features or attributes used to define boundaries between cortical regions and the establishment of correspondences of the parcellated regions across different brains. This paper uses a novel DTI-derived fiber shape feature for the parcellation of cortical gyrus into fine-granularity segments. The gyral parcellation is formulated and solved as a surface vertex clustering problem, in which fiber shape feature similarity is used to define the distances between vertices. Then, we designed and applied a novel multi-view spectral clustering algorithm to group the vertices into group-wise consistent gyral segments across different brains. The experimental results showed that the precentral and postcentral gyrus, as two test-beds, can be consistently parcellated into 10 segments on both hemispheres across different subjects. Evaluation studies using benchmark task-based fMRI and cortical landmarks demonstrated the effectiveness and validity of the proposed methods.
authors.affiliation: Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA, USA.
authors.forename: Hanbo
authors.initials: H
authors.lastname: Chen
authors.forename: Xiao
authors.initials: X
authors.lastname: Cai
authors.forename: Dajiang
authors.initials: D
authors.lastname: Zhu
authors.forename: Feiping
authors.initials: F
authors.lastname: Nie
authors.forename: Tianming
authors.initials: T
authors.lastname: Liu
authors.forename: Heng
authors.initials: H
authors.lastname: Huang
mesh_terms: D000465:Algorithms; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009415:Nerve Net / Q000033:anatomy & histology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity