title: BACE1 influences debris clearance and axonal regeneration in injured peripheral nerve.
abstract: During 3 years, my research activities in Jack Griffin's laboratory focused on the influence of β-amyloid precursor protein cleaving enzyme 1 (BACE1) on the degeneration/regeneration of sciatic nerve of mice. Here, potential mechanisms of how BACE1 enzymatic activity influences these processes are discussed.
authors.affiliation: Department of Neurology, Johns Hopkins School of Medicine, 855 N. Wolfe St., Baltimore, MD 21205, USA. mfarah2@jhmi.edu
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: Farah
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism*; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism*; D051379:Mice; D009416:Nerve Regeneration / Q000502:physiology*; D010525:Peripheral Nerves / Q000378:metabolism*; D010587:Phagocytosis / Q000502:physiology*
chemical_list: D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse