title: Cycloaromatization approach to polysubstituted indolizines from 2-acetylpyrroles: decoration of the pyridine unit.
abstract: A new synthetic route to indolizines with various substituents on the pyridine moiety was developed by utilizing a facile cycloaromatization of 2-acetylpyrrole derivatives. Without isolation, the resulting intermediates were allowed to react with various electrophiles to afford a range of indolizines. In particular, Suzuki-Miyaura cross-coupling of O-triflates with (hetero)arylboronic acids permitted introduction of diverse substituents at the C8 position of an indolizine skeleton.
authors.affiliation: College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea.
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Ikyon
authors.initials: I
authors.lastname: Kim
mesh_terms: D002384:Catalysis; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007212:Indolizines; D011725:Pyridines; D011758:Pyrroles; C051267:2-acetylpyrrole