title: Copy number variations of obesity relevant loci associated with body mass index in young Chinese.
abstract: Obesity is one of the most complex human diseases that are widely concerned and studied. More recently, copy number variations (CNVs) emerge as another important genetic marker to influence various human diseases. To elucidate the relationship between obesity and CNVs, this current study selected obesity-related candidate CNVs and analyzed their association with body mass index (BMI). Results showed that a CNV locus, 8q24.3, was significantly different (P=0.0070) in CNV frequency between the obese and healthy controls in a young eastern Chinese cohort, while no statistical significance was observed in other seven candidate loci including well reported 10q11.22 and 16p11.2 loci. The association of 8q24.3 CNVs with BMI of the subjects only showed marginal significance, while the copy number (CN) of 5p15.33 had a significant correlation with the BMI of the subject. These results suggested that 8q24.3 CN gains was associated with obesity, and 5p15.33 might also contribute to obesity pathogenesis, highlighting the importance of these CNVs for obesity risks, as well as providing new evidence for CNVs in the pathology of common diseases.
authors.affiliation: Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Sun
authors.forename: Min
authors.initials: M
authors.lastname: Cao
authors.forename: Juan
authors.initials: J
authors.lastname: Shi
authors.forename: Lijuan
authors.initials: L
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Miao
authors.forename: Jie
authors.initials: J
authors.lastname: Hong
authors.forename: Bin
authors.initials: B
authors.lastname: Cui
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D015992:Body Mass Index; D016022:Case-Control Studies; D056915:DNA Copy Number Variations / Q000502:physiology*; D005260:Female; D056726:Genetic Association Studies; D056426:Genetic Loci / Q000235:genetics*; D006801:Humans; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D055815:Young Adult