title: [Magnetic resonance spectroscopy-guided stereotactic biopsy for brain lesion].
abstract: OBJECTIVE
  To study the clinical value of magnetic resonance spectroscopy (MRS) image in stereotactic biopsy for brain lesion.
  
  
  METHODS
  From April 2008 to April 2010, 126 cases (72 male and 54 female, aged from 10 to 82 years, mean 45 years) of brain lesion which were difficult to diagnose were divided into two groups by random number table, 62 cases were executed for MRI-guided frameless stereotactic biopsy (MRI group), 64 cases were executed for MRI and MRS-guided frameless stereotactic biopsy (MRS group). Operation used MRI and Three-dimensional MRS image to locate, and used frameless CAS-R-2 robots to carry out the positioning operating.
  
  
  RESULTS
  No surgery-related deaths and infections. Pathological diagnosis was 106 cases of brain tumors, 6 cases of inflammatory disease, 4 cases of tumor-like demyelinating disease and multiple sclerosis, 3 cases of neurodegenerative disease, 7 cases failed to obtain positive pathological diagnosis. The total rate of positive diagnosis was 94.4%, the positive rate in MRS-guided stereotactic biopsy group was 98.4% (63/64), the positive rate of conventional MRI-guided biopsy group was 90.3% (56/62), and there was statistically significant difference between the two groups (χ(2) = 3.92, P = 0.047). Four cases presented with postoperative complications, the complication rate was 3.2% (4/126); the complications were cerebral hemorrhage associated with aphasia, epilepsy, subcutaneous hematoma, gastrointestinal bleeding, which were improved after treatment.
  
  
  CONCLUSIONS
  MRS-guided stereotactic biopsy group has a higher positive rate than MRI-guided stereotactic biopsy group, indicating that this method can improve the positive rate of diagnosis, and thus will help to formulate treatment plan for brain lesion.
authors.affiliation: Neurosurgery Center of People's Liberation Army, Navy General Hospital, Beijing, China.
authors.forename: Wang-sheng
authors.initials: WS
authors.lastname: Lu
authors.forename: Kui-hong
authors.initials: KH
authors.lastname: Zheng
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.forename: Bo
authors.initials: B
authors.lastname: Jia
authors.forename: Wei-gang
authors.initials: WG
authors.lastname: Ni
authors.forename: Chun-lan
authors.initials: CL
authors.lastname: Yang
authors.forename: Zeng-min
authors.initials: ZM
authors.lastname: Tian
authors.forename: Ya-ming
authors.initials: YM
authors.lastname: Wang
authors.forename: Zhi-chao
authors.initials: ZC
authors.lastname: Li
authors.forename: Yan-jie
authors.initials: YJ
authors.lastname: Sun
authors.forename: Jian-ning
authors.initials: JN
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods*; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D055815:Young Adult