title: Effects of early endometriosis on IVF-ET outcomes.
abstract: There have been very few reports on the outcomes of in vitro fertilization and embryo transfer (IVF-ET) in women with stage I/II endometriosis. The objective of this study was to investigate IVF-ET outcomes in women with early-stage endometriosis. We enrolled 35 women less than 40 years with unexplained infertility who underwent IVF-ET into the study. We compared 18 women with stage I/II endometriosis according to the revised American Society for Reproductive Medicine classification for endometriosis, who underwent 39 IVF-ET cycles (En (+) group) with 17 women without endometriosis who underwent 41 IVF-ET cycles (En (-) group). Higher requirements of total gonadotropin, a lower percentage of high-quality embryos of all fertilized eggs (9.0% vs. 16.3%), a relatively lower pregnancy rate (33.3% vs. 41.5%), and a lower live birth rate (25.6% vs. 34.1%) were observed in the En (+) group. Although no significant effect on IVF-ET outcome was observed, ovarian response may be decreased in women with stage I/II endometriosis. Considering the decreased number of high-quality embryos in the En (+) group, stage I/II endometriosis may have detrimental effects on embryo quality.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan. f041252@eve.u-ryukyu.ac.jp
authors.forename: Keiko
authors.initials: K
authors.lastname: Mekaru
authors.forename: Chiaki
authors.initials: C
authors.lastname: Yagi
authors.forename: Kozue
authors.initials: K
authors.lastname: Asato
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Masamoto
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sakumoto
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Aoki
mesh_terms: D000328:Adult; D004624:Embryo Transfer / Q000706:statistics & numerical data*; D004715:Endometriosis / Q000150:complications* / Q000473:pathology; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000628:therapy; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome