title: HR-HSBC: Measuring heteronuclear one-bond couplings with enhanced resolution.
abstract: Heteronuclear one-bond couplings have a variety of applications, and their accurate determination is the basis for obtaining specific structural information of mostly small organic compounds. In this context, it is of utmost importance to reduce signal overlap to a minimum, and a number of techniques has been introduced during the last decades. Here, we introduce a modified version of the HR-HMBC (Magn. Reson. Chem. 2010, 48, 179-183) for heteronuclear one-bond coupling measurements with improved resolution because of the J-resolved-like tilt of corresponding multiplet patterns. The pulse sequence is introduced, and its performance is compared with a standard ω(2)-coupled HSQC experiment. Example spectra on glucose and maltose demonstrate that signals can be resolved that overlap otherwise. The approach is discussed in detail.
authors.affiliation: Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, Karlsruhe, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Görling
authors.forename: Stefan
authors.initials: S
authors.lastname: Bräse
authors.forename: Burkhard
authors.initials: B
authors.lastname: Luy
mesh_terms: D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D009930:Organic Chemicals / Q000032:analysis*; D012015:Reference Standards
chemical_list: D009930:Organic Chemicals