title: Progesterone treatment before experimental hypoxia-ischemia enhances the expression of glucose transporter proteins GLUT1 and GLUT3 in neonatal rats.
abstract: Progesterone is an efficient candidate for treating stroke and traumatic brain damage. The current study was designed to investigate the effects of progesterone on glucose transporter proteins (GLUT1 and GLUT3) during hypoxic-ischemic injury in a neonatal rat model. We demonstrated strong staining for GLUT1 in the walls of blood vessels and GLUT3 immunoreactivity in hippocampal neurons after hypoxiaischemia. Hypoxia-ischemia elevated GLUT1 and GLUT3 at both the mRNA and protein levels in the hippocampus, and pre-treatment with progesterone (8 mg/kg) further enhanced their accumulation until 24 h after hypoxic-ischemic injury. These results showed that progesterone treatment induced the accumulation of both GLUT1 and GLUT3 transporters, and an energy-compensation mechanism may be involved in the neuroprotective effect of progesterone during hypoxic-ischemic injury after cerebral ischemic attacks.
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, 453003, China.
authors.forename: Xinjuan
authors.initials: X
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Han
authors.forename: Ruanling
authors.initials: R
authors.lastname: Hou
authors.forename: Linyu
authors.initials: L
authors.lastname: Wei
authors.forename: Guohong
authors.initials: G
authors.lastname: Wang
authors.forename: Chaokun
authors.initials: C
authors.lastname: Li
authors.forename: Dongliang
authors.initials: D
authors.lastname: Li
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005947:Glucose / Q000378:metabolism; D051272:Glucose Transporter Type 1 / Q000187:drug effects* / Q000378:metabolism; D051274:Glucose Transporter Type 3 / Q000187:drug effects* / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy*
chemical_list: D051272:Glucose Transporter Type 1; D051274:Glucose Transporter Type 3; D011374:Progesterone; D005947:Glucose