title: The association between CD14 gene C-260T polymorphism and coronary heart disease risk: a meta-analysis.
abstract: Monocyte differentiation antigen CD14 is considered an important cell-activating mediator of inflammatory responses that may result in atherosclerosis, coronary heart disease (CHD), thrombus formation, and myocardial infarction (MI). A common C-260T polymorphism in the promoter of the CD14 gene, the trans-membrane receptor of lipopolysaccharides, has been inconsistently associated with CHD. To investigate this inconsistency, we performed a meta-analysis of 28 studies involving a total of 13,335 CHD cases and 7,979 controls for C-260T of the CD14 gene to evaluate the effect of CD14 on genetic susceptibility for CHD. An overall random effects odds ratio of 1.24 (95 % CI: 1.12-1.36, P < 10(-5)) was found for T allele. Significant results were also observed using dominant (OR = 1.34, 95 % CI: 1.17-1.54, P < 10(-4)) or recessive genetic model (OR = 1.25, 95 % CI: 1.10-1.41, P = 0.0004). There was strong evidence of heterogeneity (P < 10(-5)), which largely disappeared after stratification by ethnicity. After stratified by ethnicity, significant results were found in East Asians; whereas no significant associations were found among Caucasians and other ethnic populations in all genetic models. In the stratified analysis according to sample size, CHD endpoints, and HWE status, significantly increased risks for the polymorphism were found in all genetic models. In conclusion, our results indicate that the CD14 C-260T polymorphism is a risk factor of CHD, especially in East Asians. However, additional very large-scale studies are warranted to confirm our results.
authors.affiliation: Department of Cardiology, The 85th Hospital of PLA, 1328 Huashan Road, Shanghai, 200052, People's Republic of China. hong_pu@126.com
authors.forename: Hong
authors.initials: H
authors.lastname: Pu
authors.forename: Jiong
authors.initials: J
authors.lastname: Yin
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Dongming
authors.initials: D
authors.lastname: Zhang
authors.forename: Yanian
authors.initials: Y
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Zhou
authors.forename: Lijuan
authors.initials: L
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
mesh_terms: D003327:Coronary Disease / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D018950:Lipopolysaccharide Receptors