title: The increased incidence of Mycoplasma pneumoniae in France in 2011 was polyclonal, mainly involving M. pneumoniae type 1 strains.
abstract: An increased incidence of Mycoplasma pneumoniae infections was reported in 2011 in two cities in France, Bordeaux and Caen. Two complementary molecular typing methods, PCR-RFLP on adhesin P1 and multilocus variable number tandem repeat analysis (MLVA), were used to determine whether this phenomenon was clonal. In 2011, the percentage of M. pneumoniae-positive patients doubled in both cities compared with 2010. Macrolide resistance remained stable at 8.3% of patients. Eighteen MLVA types were identified among 94 M. pneumoniae-positive specimens, demonstrating that the phenomenon was multiclonal. Types P, J, U, X and E were the most frequent and 81.6% of the strains were adhesin P1 type 1.
authors.affiliation: University of Bordeaux, USC Infections Humaines à Mycoplasmes et Chlamydiae, 33076, Bordeaux, France. sabine.pereyre@u-bordeaux2.fr
authors.forename: S
authors.initials: S
authors.lastname: Pereyre
authors.forename: A
authors.initials: A
authors.lastname: Touati
authors.forename: J
authors.initials: J
authors.lastname: Petitjean-Lecherbonnier
authors.forename: A
authors.initials: A
authors.lastname: Charron
authors.forename: A
authors.initials: A
authors.lastname: Vabret
authors.forename: C
authors.initials: C
authors.lastname: Bébéar
mesh_terms: D018829:Adhesins, Bacterial / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D005602:France / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D018942:Macrolides / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D017720:Molecular Epidemiology; D058889:Molecular Typing; D009177:Mycoplasma pneumoniae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D011019:Pneumonia, Mycoplasma / Q000453:epidemiology* / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D055815:Young Adult
chemical_list: D018829:Adhesins, Bacterial; D000900:Anti-Bacterial Agents; D018942:Macrolides