title: Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model.
abstract: Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare malignant tumor with no effective treatment. This study demonstrates the efficacy of BNCT with the use of human CCS-bearing nude mice. Groups A and C were administered saline, and groups B and D were injected with p-borono-L-phenylalanine-fructose complex. Groups C and D were then irradiated with thermal neutrons. The tumors in only group D disappeared, demonstrating that BNCT is a potentially new option for the treatment of human CCS.
authors.affiliation: Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi, Japan. fujitaku@hp.pref.hyogo.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Tooru
authors.initials: T
authors.lastname: Andoh
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sudo
authors.forename: Ikuo
authors.initials: I
authors.lastname: Fujita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moritake
authors.forename: Tohru
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Toshiko
authors.initials: T
authors.lastname: Sakuma
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Akisue
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawabata
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kirihata
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Fukumori
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kurosaka
authors.forename: Hideki
authors.initials: H
authors.lastname: Ichikawa
mesh_terms: D000818:Animals; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D045744:Cell Line, Tumor; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D018227:Sarcoma, Clear Cell / Q000532:radiotherapy*; D012983:Soft Tissue Neoplasms / Q000532:radiotherapy*; D023041:Xenograft Model Antitumor Assays