title: Coordinated reset has sustained aftereffects in Parkinsonian monkeys.
abstract: Coordinated reset neuromodulation consists of the application of consecutive brief high-frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long-lasting aftereffects on motor function in parkinsonian nonhuman primates. Long-lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients.
authors.affiliation: Institute for Medicine and Neurosciences, Research Center Jülich, Jülich, Germany.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Tass
authors.forename: Li
authors.initials: L
authors.lastname: Qin
authors.forename: Christian
authors.initials: C
authors.lastname: Hauptmann
authors.forename: Sandra
authors.initials: S
authors.lastname: Dovero
authors.forename: Erwan
authors.initials: E
authors.lastname: Bezard
authors.forename: Thomas
authors.initials: T
authors.lastname: Boraud
authors.forename: Wassilios G
authors.initials: WG
authors.lastname: Meissner
mesh_terms: D000818:Animals; D018592:Cross-Over Studies; D004195:Disease Models, Animal; D018450:Disease Progression; D004599:Electric Stimulation Therapy / Q000379:methods; D020267:MPTP Poisoning / Q000150:complications*; D008253:Macaca mulatta; D011597:Psychomotor Performance / Q000502:physiology*; D020531:Subthalamic Nucleus / Q000502:physiology; D016896:Treatment Outcome