title: Bone research in 2012: the ups and downs of bone in health and rheumatic disease.
abstract: In 2012, several new concepts emerged that widen our view of the regulation of bone mass in health and disease. Three key studies outline these discoveries, which affect our understanding of the skeletal system, particularly its physiological function and the changes it undergoes during inflammatory disease.
authors.affiliation: Department of Internal Medicine 3, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Harre
authors.forename: Georg
authors.initials: G
authors.lastname: Schett
mesh_terms: D001862:Bone Resorption / Q000503:physiopathology*; D001842:Bone and Bones / Q000502:physiology* / Q000503:physiopathology*; D002454:Cell Differentiation / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D053759:Interleukin-23 / Q000502:physiology; D010010:Osteoclasts / Q000166:cytology; D010012:Osteogenesis / Q000502:physiology*; D012216:Rheumatic Diseases / Q000503:physiopathology*; D040121:Semaphorin-3A / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D053759:Interleukin-23; D040121:Semaphorin-3A