title: Red blood cell deformability is very slightly decreased in erythropoietin deficient mice.
abstract: The present study compared the hemorheological properties between Epo-TAgh mice (a model of erythropoietin deficient mice) and wild-type (WT) control mice. Blood viscosity was determined at several shear rates using a cone-plate viscometer at native and adjusted hematocrit (i.e. 40%). Red blood cell (RBC) deformability was measured by ecktacytometry at several shear stresses and RBC aggregation properties by backscattered technique at adjusted hematocrit (i.e. 40%). Epo-TAgh mice had severe anemia (very low hematocrit), decreased blood viscosity at native hematocrit and slightly reduced RBC deformability at high shear stresses in comparison with WT mice. Blood viscosity at adjusted hematocrit (i.e. 40%) was not different between WT and Epo-TAgh mice. RBC aggregation did not differ between the two mice models. These findings suggest a role of erythropoietin in the regulation of RBC deformability.
authors.affiliation: Université Paris 13, Sorbonne Paris Cité, Laboratoire «Réponses cellulaires et fonctionnelles à l'hypoxie» EA2363, Bobigny, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Pichon
authors.affiliation: UMR Inserm S 665, Université des Antilles et de la Guyane/Université Paris Diderot, Hôpital Ricou, CHU de Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe.
authors.forename: Yann
authors.initials: Y
authors.lastname: Lamarre
authors.affiliation: Université Paris 13, Sorbonne Paris Cité, Laboratoire «Réponses cellulaires et fonctionnelles à l'hypoxie» EA2363, Bobigny, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Voituron
authors.affiliation: Université Paris 13, Sorbonne Paris Cité, Laboratoire «Réponses cellulaires et fonctionnelles à l'hypoxie» EA2363, Bobigny, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Marchant
authors.affiliation: Inserm U970, Centre de Recherche Cardiovasculaire, Hôpital Européen Georges Pompidou, Université Paris 5, Paris, France.
authors.forename: José
authors.initials: J
authors.lastname: Vilar
authors.affiliation: Université Paris 13, Sorbonne Paris Cité, Laboratoire «Réponses cellulaires et fonctionnelles à l'hypoxie» EA2363, Bobigny, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Richalet
authors.affiliation: UMR Inserm S 665, Université des Antilles et de la Guyane/Université Paris Diderot, Hôpital Ricou, CHU de Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe.
authors.forename: Philippe
authors.initials: P
authors.lastname: Connes
mesh_terms: D000818:Animals; D001809:Blood Viscosity; D004907:Erythrocyte Deformability / Q000502:physiology*; D004912:Erythrocytes / Q000502:physiology*; D004921:Erythropoietin / Q000172:deficiency*; D006400:Hematocrit; D018056:Hemorheology; D051379:Mice
chemical_list: D004921:Erythropoietin
keywords: Erythropoietin; anemia; hemorheology