title: Rapid microwave assisted synthesis and antimicrobial bioevaluation of novel steroidal chalcones.
abstract: A novel class of chalconoyl pregnenolones has been prepared via Claisen-Schmidt condensation under microwave activation and solvent free reaction conditions. The compounds were screened for antimicrobial activity against two bacterial strains Bacillus subtilis and Escherichia coli and two fungal strains Aspergillus niger and Candida albicans. Some of the compounds exhibited significant inhibitory activity against the microbial strains. Presence of the α,β-unsaturated carbonyl moiety in the synthesized compounds was found to be essential for the activity as manipulation of the same through epoxidation of the double bond diminished the activity.
authors.affiliation: Natural Products Chemistry Division, CSIR North East Institute of Science & Technology, Jorhat, Assam, India. dwipen_kakati@yahoo.co.in
authors.forename: Dwipen
authors.initials: D
authors.lastname: Kakati
authors.forename: Rupak K
authors.initials: RK
authors.lastname: Sarma
authors.forename: Ratul
authors.initials: R
authors.lastname: Saikia
authors.forename: Nabin C
authors.initials: NC
authors.lastname: Barua
authors.forename: Jadab C
authors.initials: JC
authors.lastname: Sarma
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects / Q000254:growth & development; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D047188:Chalcones / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D011284:Pregnenolone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D047188:Chalcones; D011284:Pregnenolone