title: Bubble CPAP versus ventilator CPAP in preterm neonates with early onset respiratory distress--a randomized controlled trial.
abstract: Bubble continuous positive airway pressure (BCPAP) is a low cost nasal CPAP delivery system with potential benefits to developing nations.
  
  
  OBJECTIVE
  To compare the efficacy and safety of BCPAP with ventilator-derived CPAP (VCPAP) in preterm neonates with respiratory distress.
  
  
  METHODS
  In a randomized controlled trial, preterm neonates with Silverman-Anderson score ≥ 4 and oxygen requirement >30% within first 6 h of life were randomly allocated to BCPAP or VCPAP. Proportion of neonates with success or failure was compared.
  
  
  RESULTS
  In all, 47 of 57 (82.5%) neonates from BCPAP group and 36 of 57 (63.2%) neonates from the VCPAP group completed CPAP successfully (p = 0.03). Neonates who failed CPAP had higher Silverman-Anderson score (p < 0.01), lower arterial to alveolar oxygenation ratio (p < 0.05) and needed surfactant more frequently (p < 0.01).
  
  
  CONCLUSIONS
  BCPAP has higher success rate than VCPAP for managing preterm neonates with early onset respiratory distress, with comparable safety.
authors.affiliation: Division of Neonatology, Department of Pediatrics, KEM Hospital, Pune 411011, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Tagare
authors.forename: Sandeep
authors.initials: S
authors.lastname: Kadam
authors.forename: Umesh
authors.initials: U
authors.lastname: Vaidya
authors.forename: Anand
authors.initials: A
authors.lastname: Pandit
authors.forename: Sanjay
authors.initials: S
authors.lastname: Patole
mesh_terms: D045422:Continuous Positive Airway Pressure / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010102:Oxygen Inhalation Therapy / Q000191:economics / Q000295:instrumentation*; D012127:Respiratory Distress Syndrome, Newborn / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome; D015300:Ventilator Weaning