title: Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice.
abstract: Animal models of viral respiratory disease often use weight loss as a marker of disease severity; however, this may relate to dehydration and malnutrition that would be corrected clinically. We tested whether parenteral fluid therapy improved weight loss from influenza infection. BALB/c and C57BL/6 mice were infected with A/X31 (H3N2) influenza and randomized to intraperitoneal fluid therapy. Blood glucose was also measured post-viral infection on day 3 and 6 in BALB/c mice and on day 6 in C57BL/6 mice. Parenteral fluids did not alter weight loss or the immunological response to infection, and glucose levels were not abnormal.
authors.affiliation: Department of Leukocyte Biology, Imperial College London, London, UK; Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, UK; Wellcome Department of Imaging Neuroscience, University College, London, UK.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Sanders
authors.forename: Alexandra
authors.initials: A
authors.lastname: Godlee
authors.forename: John C
authors.initials: JC
authors.lastname: Goulding
authors.forename: Daqing
authors.initials: D
authors.lastname: Ma
authors.forename: Mervyn
authors.initials: M
authors.lastname: Maze
authors.forename: Tracy
authors.initials: T
authors.lastname: Hussell
mesh_terms: D000818:Animals; D001786:Blood Glucose; D004195:Disease Models, Animal; D005260:Female; D005440:Fluid Therapy; D007263:Infusions, Parenteral; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D018410:Pneumonia, Bacterial / Q000276:immunology* / Q000473:pathology*; D015431:Weight Loss
chemical_list: D001786:Blood Glucose
keywords: Glucose; influenza; rehydration