title: [Outcome of renal transplantation in patients with autosomal dominant polycystic kidney disease].
abstract: BACKGROUND
  Patients with autosomal dominant polycystic kidney disease (ADPKD) have a better survival in chronic dialysis than patients with other etiologies of renal failure. It has been suggested that extra-renal manifestations of ADPKD may increase the odds of complications and mortality, if these patients are transplanted.
  
  
  OBJECTIVE
  To determine whether survival and complications in transplanted patients with ADPKD are different from kidney graft recipients with other etiologies of renal failure.
  
  
  METHODS
  Four hundred six patients with kidney transplantation were followed in three hospitals between 1976 and 2011 and 19 were carriers of ADPKD. The latter were matched by type of donor, gender, age and date of kidney transplant, with 38 graft recipients with other etiologies of renal failure.
  
  
  RESULTS
  Graft and patient 1, 5, 10 and 15 years survival were similar in both groups. Hospitalizations due to viral infections and sepsis were more common in patients with ADPKD. There were no differences in the rate of acute rejection, delayed graft function, cancer, gastrointestinal disorders and hospitalizations due to cardiovascular diseases. The frequency of graft loss due to death with a functioning kidney was similar between both groups.
  
  
  CONCLUSIONS
  Patient and graft survival in transplanted patients with ADPKD were similar to patients with other etiologies of renal failure. The rate and type of complications were similar between groups with the exception of hospitalizations due to sepsis and viral infections, which were more common in ADPKD patients.
authors.affiliation: Sección Nefrología, Servicio de Medicina Interna, Hospital Dr. Gustavo Fricke, Viña del Mar, Chile. jvegastieb@gmail.com
authors.forename: Jorge
authors.initials: J
authors.lastname: Vega
authors.forename: Daniel
authors.initials: D
authors.lastname: Lira
authors.forename: Simón
authors.initials: S
authors.lastname: Medel
authors.forename: Pablo
authors.initials: P
authors.lastname: Betancour
authors.forename: Helmuth
authors.initials: H
authors.lastname: Goecke
authors.forename: Alejandra
authors.initials: A
authors.lastname: Carrasco
mesh_terms: D000328:Adult; D005260:Female; D006085:Graft Survival; D006760:Hospitalization; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000401:mortality* / Q000601:surgery; D011183:Postoperative Complications; D015995:Prevalence; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents