title: Goblet cell carcinoid in a patient with neurofibromatosis type 1: a rare combination.
abstract: Neuroendocrine tumors are rare tumors primarily located in the gastrointestinal tract. Goblet cell carcinoid is a rare subgroup of neuroendocrine tumors located in the appendix. Neurofibromatosis type 1 is an autosomal dominant disorder caused by a mutation in the NF1 gene. Patients with neurofibromatosis type 1 have an increased incidence of typical neuroendocrine tumors, but it is unknown if this is the case with goblet cell carcinoids. We describe a patient with both neurofibromatosis type 1 and goblet cell carcinoid, that according to literature would occur in 0.00017 per million per year. This may suggest a previously unknown association between neurofibromatosis type 1 and goblet cell carcinoids.
authors.affiliation: Department of Medicine, Hepatology and Gastroenterology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Denmark.
authors.forename: Tine
authors.initials: T
authors.lastname: Gregersen
authors.forename: Nanna
authors.initials: N
authors.lastname: Holt
authors.forename: Henning
authors.initials: H
authors.lastname: Gronbaek
authors.forename: Ida
authors.initials: I
authors.lastname: Vogel
authors.forename: Lars J
authors.initials: LJ
authors.lastname: Jørgensen
authors.forename: Klaus
authors.initials: K
authors.lastname: Krogh