title: Relationship of human rectal aberrant crypt foci and formation of colorectal polyp: One-year following up after polypectomy.
abstract: OBJECTIVE
  To clarify the relationship of human rectal aberrant crypt foci and formation of colorectal polyp.
  
  
  METHODS
  Eighty-nine subjects were recruited from the population of Japanese individuals who underwent polypectomy at Yokohama City University Hospital. All patients had baseline adenomas removed at year 0 colonoscopy. Aberrant crypt foci (ACF) were defined as lesions in which the crypts were more darkly stained with methylene blue than normal crypts and had larger diameters, often with oval or slit-like lumens and a thicker epithelial lining.
  
  
  RESULTS
  A total of 366 ACFs were identified in 89 patients; all had baseline adenomas removed at the first examination (year 0) colonoscopy and returned for the second (year 1). ACF in the lower rectum were assessed at year 0 and study group were divided into two groups depend on ACF numbers, 0-3 or over 3. All participants were examined in the number and maximum size of adenoma. There was no statistical difference in number and maximum size of ACF at year 0, however, maximum size of adenoma was larger in over 3 group than 0-3 group at year 1.
  
  
  CONCLUSIONS
  The number of ACF may be a predictive factor of relatively large adenoma incidence in the pilot phase study.
authors.affiliation: Hirokazu Takahashi, Eiji Yamada, Hidenori Ohkubo, Eiji Sakai, Takuma Higurashi, Takashi Uchiyama, Kunihiro Hosono, Hiroki Endo, Atsushi Nakajima, Gastroenterology Division, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Eiji
authors.initials: E
authors.lastname: Yamada
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ohkubo
authors.forename: Eiji
authors.initials: E
authors.lastname: Sakai
authors.forename: Takuma
authors.initials: T
authors.lastname: Higurashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Hosono
authors.forename: Hiroki
authors.initials: H
authors.lastname: Endo
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
keywords: Aberrant crypt foci; Adiponectin; Colorectal carcinogenesis; Visceral fat