title: Age-dependent effects of ELF-MF on oxidative stress in the brain of Mongolian gerbils.
abstract: The aim of study was to investigate the effects of extremely low frequency magnetic field (ELF-MF; 50 Hz; 0.1, 0.25 and 0.5 mT) on oxidative stress in the brain of 3- (adult) and 10-month-old (middle-aged) gerbils. Nitric oxide (NO) level, superoxide (O2(-)) production, superoxide dismutase (SOD) activity, and index of lipid peroxidation (ILP) were measured in the forebrain cortex, striatum, hippocampus, and cerebellum immediately and 3 days after cessation of 7-day exposure. In all gerbils, ELF-MF significantly increased oxidative stress in all tested brain regions. This effect was correlated with the value of magnetic induction and was higher in middle-aged gerbils. Three days after cessation of exposure, the values of examined parameters were closer to control levels. In adult gerbils, the effect of ELF-MF of 0.1 mT on NO level, O2(-) production and SOD activity was almost fully disappeared, and ILP was at the control level regardless of the value of magnetic induction. In middle-aged gerbils, the effect of ELF-MF was still present but to a lesser degree than those observed immediately after cessation of exposure. These findings pointed out the ability of ELF-MF to induce age- and magnetic induction-dependent modification of oxidative stress in the brain.
authors.affiliation: Institute for Medical Research, MMA, Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Selaković
authors.forename: Snežana
authors.initials: S
authors.lastname: Rauš Balind
authors.forename: Lidija
authors.initials: L
authors.lastname: Radenović
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Prolić
authors.forename: Branka
authors.initials: B
authors.lastname: Janać
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005849:Gerbillinae; D015227:Lipid Peroxidation; D060526:Magnetic Fields; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D013997:Time Factors
chemical_list: D013481:Superoxides; D009569:Nitric Oxide; D013482:Superoxide Dismutase