title: Bioconjugation on cube-octameric silsesquioxanes.
abstract: Small, compact, and highly symmetric cube-octameric silsesquioxanes have recently attracted increased attention as scaffolds for tailor-made bioconjugates. The expanded arsenal of effective conjugation methods (CuAAC, TEC, oxime ligation) allows one to decorate these nanoparticles bearing up to eight addressable organic substituents, with a wide range of biorelevant ligands, among them carbohydrates, peptides, miniproteins, reporter molecules, and rare-earth chelates. Low toxicity of COSS-based molecules combined with solubility in aqueous systems and half-life sufficient for in vivo studies make these structures attractive targets for a number of applications, among them drug delivery, tumor diagnostics and therapy.
authors.affiliation: Clemens-Schöpf Institute of Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Petersenstr. 22, 64287 Darmstadt, Germany. SFabritz@Biochemie-TUD.de
authors.forename: Sebastian
authors.initials: S
authors.lastname: Fabritz
authors.forename: Sebastian
authors.initials: S
authors.lastname: Hörner
authors.forename: Olga
authors.initials: O
authors.lastname: Avrutina
authors.forename: Harald
authors.initials: H
authors.lastname: Kolmar
mesh_terms: D000818:Animals; D002241:Carbohydrates / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D012825:Silicon / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D012833:Siloxanes / Q000737:chemistry
chemical_list: D002241:Carbohydrates; D004337:Drug Carriers; D009942:Organometallic Compounds; D010455:Peptides; D012833:Siloxanes; D012822:Silicon Dioxide; D012825:Silicon