title: Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity.
abstract: Combined coordination of Zn(II) and Cu(I) or Cu(II) to the amyloid-β peptide has been investigated using XANES, EPR and NMR spectroscopies. While Zn(II) does alter Cu(II) binding to Aβ, this has no effect on (Aβ)Cu induced ROS production and associated cell toxicity.
authors.affiliation: CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, F-31077 Toulouse, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Alies
authors.forename: Isabelle
authors.initials: I
authors.lastname: Sasaki
authors.forename: Olivier
authors.initials: O
authors.lastname: Proux
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Sayen
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Guillon
authors.forename: Peter
authors.initials: P
authors.lastname: Faller
authors.forename: Christelle
authors.initials: C
authors.lastname: Hureau
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000633:toxicity; D003300:Copper / Q000737:chemistry*; D006801:Humans; D010446:Peptide Fragments / Q000737:chemistry*; D011485:Protein Binding; D017382:Reactive Oxygen Species / Q000378:metabolism; D015032:Zinc / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D056831:Coordination Complexes; D010446:Peptide Fragments; D017382:Reactive Oxygen Species; C078592:amyloid beta-protein (1-40); D003300:Copper; D015032:Zinc