title: Different indications, warnings and precautions, and contraindications for the same drug--an international comparison of prescribing information for commonly used psychiatric drugs.
abstract: OBJECTIVE
  We aim to derive an internationally applicable data set to improve prescription safety of psychiatric drugs.
  
  
  METHODS
  We performed an in-depth analysis of the concordance of prescribing information of 10 key psychiatric drugs across four major drug markets with regard to indications, warnings and precautions, and contraindications.
  
  
  RESULTS
  The individual prescribing information covered on average 71.4 ± 30.3% of all named indications, 59.5 ± 17.1% of all potential warnings and precautions and 70.1 ± 24.4% of all applicable contraindications.
  
  
  CONCLUSIONS
  This substantial variation in key prescribing information across countries highlights the need for a better international cooperation and standardization of prescribing information.
authors.affiliation: Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Pfistermeister
authors.forename: Christian
authors.initials: C
authors.lastname: Schenk
authors.forename: Johannes
authors.initials: J
authors.lastname: Kornhuber
authors.forename: Thomas
authors.initials: T
authors.lastname: Bürkle
authors.forename: Martin F
authors.initials: MF
authors.lastname: Fromm
authors.forename: Renke
authors.initials: R
authors.lastname: Maas
mesh_terms: D032921:Consensus; D000075202:Contraindications; D003299:Cooperative Behavior; D004348:Drug Labeling / Q000592:standards; D004363:Drug Utilization; D005060:Europe; D019983:Guideline Adherence; D006801:Humans; D007391:International Cooperation; D061214:Patient Safety; D017891:Pharmacoepidemiology; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000592:standards; D011619:Psychotropic Drugs / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D014481:United States
chemical_list: D011619:Psychotropic Drugs