title: [CCR5, CCR2, apoe, p53, ITGB3 and HFE gene polymorphism in Western Siberia long-livers].
abstract: In order to estimate the distribution of some polymorphisms for the CCR5, CCR2, apoE, p53, ITGB3, and HFE genes in Russian long-livers from Western Siberia, a sample of 271 individuals (range 90-105 years) was examined. It was demonstrated that carriage of the delta32 polymorphism for the CCR5 gene, V64/polymorphism for the CCR2 gene, e2/e3/e4 for the apoE gene, L33P for the ITGB3 gene, as well as H63D and S65C polymorphisms for the HFE gene does not influence on predisposition to the longevity; carriage of the 282 Y allele for the HFE gene negatively influences on the longevity; carriage of the heterozygous genotype for the R72P polymorphism for the p53 gene correlates with the longevity of elderly people.
authors.forename: D E
authors.initials: DE
authors.lastname: Ivanoshchuk
authors.forename: S V
authors.initials: SV
authors.lastname: Mikhaĭlova
authors.forename: I V
authors.initials: IV
authors.lastname: Kulikov
authors.forename: V N
authors.initials: VN
authors.lastname: Maksimov
authors.forename: M I
authors.initials: MI
authors.lastname: Voevoda
authors.forename: A G
authors.initials: AG
authors.lastname: Romashchenko
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005787:Gene Frequency; D016158:Genes, p53 / Q000235:genetics*; D005838:Genotype; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D008136:Longevity / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*; D012800:Siberia
chemical_list: D001057:Apolipoproteins E; C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; C061248:ITGB3 protein, human; D039661:Integrin beta3; D008565:Membrane Proteins; D019713:Receptors, CCR5; D004247:DNA