title: The role of chromatin insulators in nuclear architecture and genome function.
abstract: Eukaryotic genomes are intricately arranged into highly organized yet dynamic structures that underlie patterns of gene expression and cellular identity. The recent adaptation of novel genomic strategies for assaying nuclear architecture has significantly extended and accelerated our ability to query the nature of genome organization and the players involved. In particular, recent explorations of physical arrangements and chromatin landscapes in higher eukaryotes have demonstrated that chromatin insulators, which mediate functional interactions between regulatory elements, appear to play an important role in these processes. Here we reflect on current findings and our rapidly expanding understanding of insulators and their role in nuclear architecture and genome function.
authors.affiliation: Department of Biology, Emory University, Atlanta, GA 30322, United States.
authors.forename: Kevin
authors.initials: K
authors.lastname: Van Bortle
authors.forename: Victor G
authors.initials: VG
authors.lastname: Corces
mesh_terms: D000818:Animals; D000076246:CCCTC-Binding Factor; D002453:Cell Cycle / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics; D002843:Chromatin / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics; D056890:Eukaryota / Q000166:cytology / Q000235:genetics; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D038101:Insulator Elements / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*
chemical_list: D000076246:CCCTC-Binding Factor; C000619697:CTCF protein, human; D002843:Chromatin; D012097:Repressor Proteins