title: Fabrication of hollow and porous structured GdVO4:Dy3+ nanospheres as anticancer drug carrier and MRI contrast agent.
abstract: Hollow and porous structured GdVO(4):Dy(3+) spheres were fabricated via a facile self-sacrificing templated method. The large cavity allows them to be used as potential hosts for therapeutic drugs, and the porous feature of the shell allows guest molecules to easily pass through the void space and surrounding environment. The samples show strong yellow-green emission of Dy(3+) (485 nm, (4)F(9/2) → (6)H(15/2); 575 nm, (4)F(9/2) → (6)H(13/2)) under UV excitation. The emission intensity of GdVO(4):Dy(3+) was weakened after encapsulation of anticancer drug (doxorubicin hydrochloride, DOX) and gradually restored with the cumulative released time of DOX. These hollow spheres were nontoxic to HeLa cells, while DOX-loaded samples led to apparent cytotoxicity as a result of the sustained release of DOX. ICP measurement indicates that free toxic Gd ions can hardly dissolate from the matrix. The endocytosis process of DOX-loaded hollow spheres is observed using confocal laser scanning microscopy (CLSM). Furthermore, GdVO(4):Dy(3+) hollow spheres can be used for T(1)-weighted magnetic resonance (MR) imaging. These results implicate that the luminescent GdVO(4):Dy(3+) spheres with hollow and porous structure are promising platforms for drug storage/release and MR imaging.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Kang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yang
authors.forename: Ping'an
authors.initials: P
authors.lastname: Ma
authors.forename: Yunlu
authors.initials: Y
authors.lastname: Dai
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Shang
authors.forename: Dongling
authors.initials: D
authors.lastname: Geng
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000138:chemical synthesis*; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis*; D004339:Drug Compounding; D004419:Dysprosium / Q000737:chemistry*; D004705:Endocytosis; D005682:Gadolinium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D018613:Microscopy, Confocal; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D014638:Vanadates / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D004337:Drug Carriers; D004419:Dysprosium; D014638:Vanadates; D004317:Doxorubicin; D005682:Gadolinium