title: Antifungal activity of 10 Guadeloupean plants.
abstract: Screening of the antifungal activities of ten Guadeloupean plants was undertaken to find new extracts and formulations against superficial mycoses such as onychomycosis, athlete's foot, Pityriasis versicolor, as well as the deep fungal infection Pneumocystis pneumonia. For the first time, the CMI of these plant extracts [cyclohexane, ethanol and ethanol/water (1:1, v/v)] was determined against five dermatophytes, five Candida species, Scytalidium dimidiatum, a Malassezia sp. strain and Pneumocystis carinii. Cytotoxicity tests of the most active extracts were also performed on an HaCat keratinocyte cell line. Results suggest that the extracts of Bursera simaruba, Cedrela odorata, Enterolobium cyclocarpum and Pluchea carolinensis have interesting activities and could be good candidates for developing antifungal formulations.
authors.affiliation: UDSL, EA4481 GRIIOT, Laboratoire de Pharmacognosie, Université Lille Nord de France F-59000 Lille, Faculté de Pharmacie, France; APLAMEDAROM, Association des Plantes Médicinales et Aromatiques de Guadeloupe, Mompierre, 97111, Morne-à-l'eau, Guadeloupe, France.
authors.forename: Murielle
authors.initials: M
authors.lastname: Biabiany
authors.forename: Vincent
authors.initials: V
authors.lastname: Roumy
authors.forename: Thierry
authors.initials: T
authors.lastname: Hennebelle
authors.forename: Nadine
authors.initials: N
authors.lastname: François
authors.forename: Boualem
authors.initials: B
authors.lastname: Sendid
authors.forename: Muriel
authors.initials: M
authors.lastname: Pottier
authors.forename: El Moukhtar
authors.initials: el M
authors.lastname: Aliouat
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rouaud
authors.forename: Françoise
authors.initials: F
authors.lastname: Lohézic-Le Dévéhat
authors.forename: Henry
authors.initials: H
authors.lastname: Joseph
authors.forename: Paul
authors.initials: P
authors.lastname: Bourgeois
authors.forename: Sevser
authors.initials: S
authors.lastname: Sahpaz
authors.forename: François
authors.initials: F
authors.lastname: Bailleul
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D019659:Asteraceae / Q000737:chemistry; D031233:Bursera / Q000737:chemistry; D002175:Candida / Q000187:drug effects; D031587:Cedrela / Q000737:chemistry; D002460:Cell Line; D007887:Fabaceae / Q000737:chemistry; D019430:Guadeloupe; D006801:Humans; D008290:Malassezia / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D045363:Pneumocystis carinii / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts
keywords: Bursera; Cedrela; Enterolobium; Pluchea; Pneumocystis; antifungal extract