title: Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial.
abstract: BACKGROUND
  The inability of the normal adult population to perform adequate tooth brushing has led to the search for chemotherapeutic agents in order to improve plaque control. This 6 month, single center, randomized controlled clinical trial was conducted to assess the clinical and microbiological effects of a dentifrice containing only amine fluoride (AF) as the active ingredient on gingivitis.
  
  
  METHODS
  NINETY SUBJECTS DIAGNOSED WITH CHRONIC GENERALIZED GINGIVITIS WERE SELECTED AND RANDOMLY DIVIDED IN THREE GROUPS: Group 1 - placebo toothpaste, Group 2 - AF containing toothpaste, and Group 3 - triclosan containing toothpaste with polymer and fluoride. Clinical evaluation was undertaken using the gingival index of Loe and Silness and the plaque index and microbiological counts were assessed at baseline, 6 weeks, 12 weeks, and 24 weeks. A subjective evaluation was also undertaken by a questionnaire.
  
  
  RESULTS
  AF containing toothpaste showed significant improvement in gingival and plaque index scores as well as microbiologic counts compared with placebo dentifrice. These improvements were comparable to triclosan containing toothpaste.
  
  
  CONCLUSIONS
  AF containing toothpaste may be a useful formulation for chemical plaque control agent and improvement in plaque and gingival status and add to the list of various therapeutic agents used for maintenance of gingival health.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Fort, Bangalore, Karnataka, India.
authors.forename: A R
authors.initials: AR
authors.lastname: Pradeep
authors.forename: Esha
authors.initials: E
authors.lastname: Agarwal
authors.forename: Pavan
authors.initials: P
authors.lastname: Bajaj
authors.forename: Savitha B
authors.initials: SB
authors.lastname: Naik
authors.forename: Minal
authors.initials: M
authors.lastname: Kumari
authors.forename: C N
authors.initials: CN
authors.lastname: Guruprasad
keywords: Antiinflammatory agent; antiplaque agent; clinical trial; gingivitis