title: Clopidogrel has no effect on mortality from hip fracture.
abstract: Over 76,000 patients in the UK sustain a proximal femoral fracture. Clopidogrel is currently the world's second best selling drug. There has been much recent controversy surrounding the optimal time for surgical intervention in this medically challenging group of patients. This consecutive series of 1225 patients from our unit over six years included thirty patients concurrently taking clopidogrel whilst sustaining a hip fracture. Our study demonstrated no significant difference in ASA grade, intra-operative blood loss or subsequent transfusion, post-operative wound complication, or mortality to one year in those taking clopidogrel. The authors therefore advocate timely surgical intervention as rapidly as circumstances allow.
authors.affiliation: Trauma and Orthopaedics, East of England Multi-Professional Deanery, Capital Park, Fulbourn, Cambridge, United Kingdom. drwordsworth@doctors.net.uk.
authors.forename: D R
authors.initials: DR
authors.lastname: Wordsworth
authors.forename: T
authors.initials: T
authors.lastname: Halsey
authors.forename: R
authors.initials: R
authors.lastname: Griffiths
authors.forename: M J
authors.initials: MJ
authors.lastname: Parker
mesh_terms: D054058:Acute Coronary Syndrome / Q000401:mortality* / Q000517:prevention & control; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000401:mortality*; D001241:Aspirin / Q000627:therapeutic use; D016063:Blood Loss, Surgical / Q000517:prevention & control; D001803:Blood Transfusion; D000077144:Clopidogrel; D005260:Female; D006620:Hip Fractures / Q000401:mortality* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D012720:Severity of Illness Index; D020521:Stroke / Q000401:mortality* / Q000517:prevention & control; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin