title: [Caloric restriction in primates: how efficient as an anti-aging approach?].
abstract: Caloric restriction (CR) is the only non-genetic intervention known to date to slow the onset of age-related diseases and increase average and maximum lifespan in several species. Its interest is continually growing, particularly for the identification of mechanisms involved in increasing longevity. Unlike studies in invertebrate and rodent models have provided some indication about the mechanisms of the CR, the efficacy of CR as an anti-aging protocol in primates has not yet been fully established. In this review we present the advantages of using non human primates as relevant models to the study of human aging in general and specifically in the context of therapeutic interventions applicable to humans, such as CR. Through the longitudinal findings in the Grey Mouse Lemur (Microcebus murinus), we stress the importance of primate studies in the context of research on aging and their potential to advance the development of molecules which can mimic the beneficial effects of CR, already observed in some species, without imposing a reduced calorie diet.
authors.affiliation: CNRS UMR 7179, mécanismes adaptatifs (des organismes aux communautés), Muséum national d'histoire naturelle, 1, avenue du Petit Château, 91800 Brunoy, France. marchal.julia@gmail.com
authors.forename: Julia
authors.initials: J
authors.lastname: Marchal
authors.forename: Martine
authors.initials: M
authors.lastname: Perret
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
mesh_terms: D000375:Aging / Q000378:metabolism / Q000502:physiology*; D019588:Aging, Premature / Q000628:therapy* / Q000662:veterinary; D000818:Animals; D031204:Caloric Restriction / Q000662:veterinary; D016565:Cheirogaleidae / Q000502:physiology; D006801:Humans; D008136:Longevity / Q000502:physiology; D008251:Macaca / Q000502:physiology; D023421:Models, Animal; D011323:Primates / Q000378:metabolism / Q000502:physiology*