title: Herpes simplex virus type 2 infection among females in Enugu, Enugu State.
abstract: BACKGROUND
  Herpes simplex virus type 2 infecion is life long with manifestation in a small proportion of those infected. It has presented public health concern because of its progressively increasing prevalence which some authorities say is of epidemic proportion in developing countries. Herpes simplex virus type 2 has recently been found to have synergistic effect with human immunodeficiency virus (HIV) and co-infection of the two presents more severe burden to the immunity of the victim. This leads to much morbidity and mortality with negative economic impact. In this study, we set out to determine antibody prevalence of HSV-2 in women attending skin and ante natal care [ANC] clinics in University of Nigeria Teaching Hospital [UNTH] and Enugu State University Teaching Hospital [ESUTH].
  
  
  METHODS
  180 female patients/clients attending skin and ANC clinics in UNTH and ESUTH were enrolled in this descriptive study. Sociodemographic data and medical history were collected using a questionnaire. They were also examined for signs of HSV 2 manifestation, other STIs and WHO staging if HIV positive. Samples were also taken for serology, Gram staining and CD4 T-lymphocyte count.
  
  
  RESULTS
  The prevalence of HSV 2 was found to be 77.8% (n=137) and 14.6% (n=20) had clinical diagnosis of HSV-2.The HIV and HSV-2 co-infection rate was 5.11% (n=9) and out of 11 that were HIV positive, 9 (81.82%) were HSV-2 antibody positive. The HIV prevalence in this study was 6.3%.
  
  
  CONCLUSIONS
  Herpes simplex virus type 2 infection is common among females in Enugu, Enugu State and is commoner among those with HIV infection.
authors.affiliation: College of Medicine, University of Nigeria, Enugu Campus.
authors.forename: U R
authors.initials: UR
authors.lastname: Ojinmah
authors.forename: E N
authors.initials: EN
authors.lastname: Nnoruka
authors.forename: G A O
authors.initials: GA
authors.lastname: Ozoh
authors.forename: C L
authors.initials: CL
authors.lastname: Onyekonwu
authors.forename: E N
authors.initials: EN
authors.lastname: Aguwa
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D015897:Comorbidity; D005260:Female; D015658:HIV Infections / Q000453:epidemiology; D006561:Herpes Simplex / Q000453:epidemiology* / Q000276:immunology; D018258:Herpesvirus 2, Human / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D013587:Syphilis / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral