title: Hypericum perforatum extract therapy for chickens experimentally infected with infectious bursal disease virus and its influence on immunity.
abstract: Hypericum perforatum extract (HPE) has been proved a drug effective to many viral diseases. The purpose of this paper was to investigate the therapeutic efficacy and immuno-enhancement of HPE for chickens which were already challenged with infectious bursal disease virus (IBDV BC-6/85). Chickens infected with IBDV were treated with HPE for 5 consecutive days, the observation of immune organ indexes and pathological changes index, determination of IFN-α and detection of IBDV with RT-PCR were employed to assess in vivo whether or not HPE had the certain therapeutic efficacy on infectious bursal disease (IBD), and if HPE was able to improve the immunologic function. The results showed that 1330 and 667.9 mg/kg body weight (BW) per day of HPE had significant therapeutic efficacy and improvement immunologic functions for chickens infected experimentally with IBDV.
authors.affiliation: Key Laboratory of New Animal Drug Project, Gansu Province, Lanzhou Institute of Animal Science and Veterinary Pharmaceutics Science, Chinese Academy of Agricultural Sciences, Lanzhou 730050, P.R. China. shangrf1974@163.com
authors.forename: Ruofeng
authors.initials: R
authors.lastname: Shang
authors.forename: Cheng
authors.initials: C
authors.lastname: He
authors.forename: Jiongran
authors.initials: J
authors.lastname: Chen
authors.forename: Xiuying
authors.initials: X
authors.lastname: Pu
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Lanying
authors.initials: L
authors.lastname: Hua
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Jianping
authors.initials: J
authors.lastname: Liang
mesh_terms: D000818:Animals; D018175:Birnaviridae Infections / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D002060:Bursa of Fabricius / Q000821:virology; D002645:Chickens; D020902:Hypericum / Q000737:chemistry*; D007153:Immunologic Deficiency Syndromes; D007243:Infectious bursal disease virus; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000188:drug therapy* / Q000821:virology; D000081207:Primary Immunodeficiency Diseases; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013154:Spleen / Q000002:abnormalities / Q000187:drug effects / Q000502:physiology
chemical_list: D010936:Plant Extracts