title: Rotenoid derivatives from Derris trifoliata with nitric oxide production inhibitory activity.
abstract: Study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) collected in Singapore led to the isolation and identification of three known and two new rotenoid derivatives. The new derivatives, named derrisfolin A (1) and B (2), inhibited nitric oxide production in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma and lipopolysaccharide.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
authors.forename: Tomiyasu
authors.initials: T
authors.lastname: Murata
authors.forename: Hugh T-W
authors.initials: HT
authors.lastname: Tan
authors.forename: Norio
authors.initials: N
authors.lastname: Kaneda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
authors.forename: Masataka
authors.initials: M
authors.lastname: Itoigawa
mesh_terms: D000818:Animals; D002460:Cell Line; D029866:Derris / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D012402:Rotenone / Q000031:analogs & derivatives*
chemical_list: D012402:Rotenone; D009569:Nitric Oxide