title: Research challenges in endocrine aspects of canine ovarian cycles.
abstract: Significant deficiencies exist in understanding factors controlling the nature and timing of critical endocrine changes in canine ovarian cycles. The following merit further study: changes in steroid clearance and binding; mathematically modelling periovulatory hormone rate of change interactions; luteal gonadotropin dependence; endogenous circannual cycles underlying the ovarian cycle; importance of periovulatory follicular steroid dynamics on granulosa and oocytes; in vitro capacity of anoestrous ovarian tissue to demonstrate roles of individual gonadotropins and steroid precursors to increase oestradiol production; factors affecting secretion and activation of the canine female sex pheromone.
authors.affiliation: Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
authors.forename: P W
authors.initials: PW
authors.lastname: Concannon
mesh_terms: D000818:Animals; D004285:Dogs / Q000502:physiology*; D030762:Estrous Cycle / Q000502:physiology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood* / Q000378:metabolism*; D010053:Ovary / Q000502:physiology*
chemical_list: D012739:Gonadal Steroid Hormones