title: Dipeptide cis-cyclo(Leucyl-Tyrosyl) produced by sponge associated Penicillium sp. F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis.
abstract: Infections associated to microbial biofilms are involved in 80% of human infections and became a challenge concerning public health. Infections related to Staphylococcus epidermidis biofilms are presently commonly associated to medical devices, increasing treatment costs for this type of infection. Alternatives to eliminate this kind of disease have been employed in screening programs using diverse marine-derived fungi source of bioactive compounds capable to combat biofilm formation. In this work was isolated the dipeptide cis-cyclo(Leucyl-Tyrosyl) from a sponge associated Penicillium sp. possessing a remarkable inhibition up to 85% of biofilm formation without interfering with bacterial growth, confirmed by scanning electron microscopy. This is the first demonstration that cis-cyclo(Leucyl-Tyrosyl) is able to specifically inhibit biofilm formation adding another aspect to the broad spectrum of bioactivities of cyclic dipeptides.
authors.affiliation: Faculdade de Farmácia, Departamento de Produção de Matéria-Prima, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000 Porto Alegre, Brazil.
authors.forename: Marina
authors.initials: M
authors.lastname: Scopel
authors.forename: Wolf-Rainer
authors.initials: WR
authors.lastname: Abraham
authors.forename: Amélia T
authors.initials: AT
authors.lastname: Henriques
authors.forename: Alexandre J
authors.initials: AJ
authors.lastname: Macedo
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011161:Porifera / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D010456:Peptides, Cyclic; C562328:cyclo(leucyl-tyrosyl)