title: A simple and sensitive spectrofluorimetric method for the determination of furosemide using zinc(II)-1,4-bis(imidazol-1-ylmethyl)benzene complexes.
abstract: A novel spectrofluorometric method for the determination of furosemide (FUR) is described. The method is based on enhancement of fluorescence emission of FUR in the presence of zinc (II) complexes of 1,4-bis(imidazol-1-ylmethyl)benzene. Under optimum conditions, the enhanced fluorescence intensity is linearly related to the concentration of FUR. The proposed method has been successfully applied to the determination of FUR in pharmaceutical preparations. The possible mechanism of this reaction is discussed briefly based on data from fluorescence spectroscopy, UV-vis absorption and infrared spectroscopy.
authors.affiliation: Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, People's Republic of China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Liu
authors.forename: Huijuan
authors.initials: H
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Yuanfang
authors.initials: Y
authors.lastname: Li
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D005665:Furosemide / Q000032:analysis*; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods*; D013607:Tablets
chemical_list: D056831:Coordination Complexes; D007093:Imidazoles; D013607:Tablets; D005665:Furosemide
keywords: 1,4-bis(imidazol-1-ylmethyl)benzene (bix); FUR; fluorescence increasing; spectrofluorometry