title: Antimicrobial, antioxidant and anti-inflammatory activity of young shoots of the smoke tree, Cotinus coggygria Scop.
abstract: In this study, we investigated the antimicrobial activity of the young shoots of the smoke tree, Cotinus coggygria Scop., Anacardiaceae. The acetone extract and the derived ethyl acetate fraction effectively inhibited the growth of Gram-positive and Gram-negative bacteria (MIC 25-200 µg/ml), while the chloroform fraction showed pronounced activity against the yeast Candida albicans (MIC 3.12 µg/ml). The ethyl acetate fraction exhibited a significant ferric-reducing ability (10.7 mmol Fe(2+) /g extract), a very high DPPH radical scavenging activity (SC50  = 1.7 µg/ml) and inhibition of lipid peroxidation (IC50  = 41.8 µg/ml). High amounts of total phenolics (929.8 mg/g), tannins (833.8 mg/g) and flavonoids (35.5 mg/g) were determined in the ethyl acetate fraction, which also exerted significant anti-inflammatory (76.7%) and cytotoxic effects (IC50  = 15.6 µg/ml).
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, 11221, Belgrade, Serbia.
authors.forename: Mirjana
authors.initials: M
authors.lastname: Marčetić
authors.forename: Dragana
authors.initials: D
authors.lastname: Božić
authors.forename: Marina
authors.initials: M
authors.lastname: Milenković
authors.forename: Nevenka
authors.initials: N
authors.lastname: Malešević
authors.forename: Siniša
authors.initials: S
authors.lastname: Radulović
authors.forename: Nada
authors.initials: N
authors.lastname: Kovačević
mesh_terms: D027926:Anacardiaceae / Q000737:chemistry*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018520:Plant Shoots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013634:Tannins / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D013634:Tannins
keywords: Cotinus coggygria; anti-inflammatory activity; antimicrobial activity; antioxidant activity; young shoots