title: Retinal angiomatous proliferation occurring after radiotherapy.
abstract: OBJECTIVE
  To describe two cases of retinal angiomatous proliferation (RAP)-like lesion following radiation therapy for primary tumor.
  
  
  METHODS
  Retrospective evaluation of two patients with previous irradiation treatment for a pleomorphic adenoma of the lacrimal gland and a vocal cord carcinoma, respectively. Visual acuity (VA), fluorescein angiography and optical coherence tomography were performed and demonstrated a RAP-like lesion in both cases. Treatment with intravitreal injections of Ranibizumab was performed with a follow-up of 19 and 10 months, respectively.
  
  
  RESULTS
  Both the patients had a positive response to the treatment with improvement in VA and reduction of intraretinal fluid.
  
  
  CONCLUSIONS
  RAP-like lesions can develop following radiation treatment for a primary tumor. In patients presenting with idiopathic RAP, a history of prior radiotherapy should be considered.
authors.affiliation: Southampton Eye Unit, University Hospital Southampton, Southampton, UK.
authors.forename: G
authors.initials: G
authors.lastname: De Salvo
authors.forename: S R
authors.initials: SR
authors.lastname: Hannan
authors.forename: N
authors.initials: N
authors.lastname: James
authors.forename: A J
authors.initials: AJ
authors.lastname: Lotery
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology / Q000532:radiotherapy; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D005134:Eye Neoplasms / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000473:pathology / Q000532:radiotherapy; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D011832:Radiation Injuries / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D000069579:Ranibizumab; D012160:Retina / Q000528:radiation effects*; D015861:Retinal Neovascularization / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014827:Vocal Cords / Q000528:radiation effects
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D000069579:Ranibizumab