title: Myocardial protection during off pump coronary artery bypass surgery: a comparison of inhalational anesthesia with sevoflurane or desflurane and total intravenous anesthesia.
abstract: OBJECTIVE
  The objective of the study was to evaluate the myocardial protective effect of volatile agents-sevoflurane and desflurane versus total intravenous anesthesia (TIVA) with propofol in offpump coronary artery bypass surgery (OPCAB) by measuring cardiac troponin-T (cTnT) as a marker of myocardial cell death.
  
  
  METHODS
  The study was conducted on 139 patients scheduled to undergo elective OPCAB surgery. The patients were randomly allocated to receive anesthesia with sevoflurane, desflurane or TIVA with propofol. The cTnT levels were measured preoperatively, at arrival in postoperative intensive care unit, at 8, 24, 48 and 96 hours thereafter.
  
  
  RESULTS
  The changes in cTnT levels at all time intervals were comparable in the three groups.
  
  
  CONCLUSIONS
  The study did not reveal any difference in myocardial protection after OPCAB with either sevoflurane or desflurane or TIVA using propofol as assessed by measuring serial cTnT values.
authors.affiliation: Department of Anesthesiology, Fortis Hospital, Bannerghatta Road, Bangalore, Karnataka 560 052, India.
authors.forename: Sharadaprasad
authors.initials: S
authors.lastname: Suryaprakash
authors.forename: Murali
authors.initials: M
authors.lastname: Chakravarthy
authors.forename: Geetha
authors.initials: G
authors.lastname: Muniraju
authors.forename: Saurabh
authors.initials: S
authors.lastname: Pandey
authors.forename: Swapnil
authors.initials: S
authors.lastname: Pandey
authors.forename: Sona
authors.initials: S
authors.lastname: Mitra
authors.forename: Benak
authors.initials: B
authors.lastname: Shivalingappa
authors.forename: Stany
authors.initials: S
authors.lastname: Chittiappa
authors.forename: Jayaprakash
authors.initials: J
authors.lastname: Krishnamoorthy
mesh_terms: D000368:Aged; D000769:Anesthesia, Inhalation / Q000379:methods*; D000771:Anesthesia, Intravenous / Q000379:methods*; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D009202:Cardiomyopathies / Q000473:pathology / Q000517:prevention & control*; D016923:Cell Death / Q000187:drug effects; D047549:Coronary Artery Bypass, Off-Pump / Q000379:methods*; D000077335:Desflurane; D048909:Diabetes Complications; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007530:Isoflurane / Q000031:analogs & derivatives*; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D015742:Propofol; D011446:Prospective Studies; D000077149:Sevoflurane; D020107:Troponin T / Q000097:blood
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D020107:Troponin T; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane; D015742:Propofol