title: Synthesis of novel therapeutic agents for the treatment of multiple sclerosis: a brief overview.
abstract: Multiple sclerosis (MS) often results in chronic inflammatory and autoimmune disorders, and recent developments in understanding the disease pathogenesis has lead to newer therapeutic options for the treatment of the disease. The development of small molecule drugs with improved efficacy, better tolerability, and oral administration has received a new impetus with the discovery of newer classes of drugs. In this review, we have summarized the hitherto known synthetic strategies of fingolimod, laquinimod, cladribine, and teriflunomide reported in the literature which are the key small molecules and the first oral drug candidates for MS in various stages of clinical development or have been launched in the market.
authors.affiliation: COSMIC Discoveries, Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India.
authors.forename: Naveen
authors.initials: N
authors.lastname: Mulakayala
authors.forename: Pallavi
authors.initials: P
authors.lastname: Rao
authors.forename: Javed
authors.initials: J
authors.lastname: Iqbal
authors.forename: Rakeshwar
authors.initials: R
authors.lastname: Bandichhor
authors.forename: Srinivas
authors.initials: S
authors.lastname: Oruganti
mesh_terms: D017338:Cladribine / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D003437:Crotonates / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D000068876:Fingolimod Hydrochloride; D006801:Humans; D006885:Hydroxybutyrates; D015394:Molecular Structure; D009103:Multiple Sclerosis / Q000188:drug therapy*; D009570:Nitriles; D011409:Propylene Glycols / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D014052:Toluidines / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D003437:Crotonates; D006885:Hydroxybutyrates; D009570:Nitriles; D011409:Propylene Glycols; D015363:Quinolones; D054852:Small Molecule Libraries; D014052:Toluidines; C527525:teriflunomide; D017338:Cladribine; C476223:laquinimod; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine