title: The overexpression of the trypanosomatid-exclusive TcRBP19 RNA-binding protein affects cellular infection by Trypanosoma cruzi.
abstract: To characterise the trypanosomatid-exclusive RNA-binding protein TcRBP19, we analysed the phenotypic changes caused by its overexpression. Although no evident changes were observed when TcRBP19 was ectopically expressed in epimastigotes, the metacyclogenesis process was affected. Notably, TcRBP19 overexpression also led to a decrease in the number of infected mammalian cells. These findings suggest that TcRBP19 may be involved in the life cycle progression of the Trypanosoma cruzi parasite.
authors.affiliation: Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Montevideo, Uruguay.
authors.forename: Leticia
authors.initials: L
authors.lastname: Pérez-Díaz
authors.forename: Alejandro
authors.initials: A
authors.lastname: Correa
authors.forename: Mariana P
authors.initials: MP
authors.lastname: Moretão
authors.forename: Samuel
authors.initials: S
authors.lastname: Goldenberg
authors.forename: Bruno
authors.initials: B
authors.lastname: Dallagiovanna
authors.forename: Beatriz
authors.initials: B
authors.lastname: Garat
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D008018:Life Cycle Stages; D015800:Protozoan Proteins / Q000502:physiology*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D014349:Trypanosoma cruzi / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism
chemical_list: D015800:Protozoan Proteins; C581870:RBP19 protein, Trypanosoma cruzi; D016601:RNA-Binding Proteins