title: Addition of cyclic ureas and 1-methyl-2-oxazolidone to pyridynes: a new approach to pyridodiazepines, pyridodiazocines, and pyridooxazepines.
abstract: Reactions of pyridynes with cyclic urea and 1-methyl-2-oxazolidone were demonstrated. 3,4-Pyridyne and 2,3-pyridyne were reacted with N,N-dimethylimidazolidone, N,N-dimethylpropylene urea, and 1-methyl-2-oxazolidone to give the corresponding pyridodiazepines, pyridodiazocines, and pyridooxazepines, respectively.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. nozomi-s@pharm.hokudai.ac.jp
authors.forename: Nozomi
authors.initials: N
authors.lastname: Saito
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Sayako
authors.initials: S
authors.lastname: Shibano
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ide
authors.forename: Masabumi
authors.initials: M
authors.lastname: Minami
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sato
mesh_terms: D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D001392:Azocines / Q000138:chemical synthesis* / Q000737:chemistry; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010077:Oxazepines / Q000138:chemical synthesis* / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D023303:Oxazolidinones / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D014508:Urea / Q000737:chemistry*
chemical_list: C581024:1-methyl-2-oxazolidone; D001381:Azepines; D001392:Azocines; D001555:Benzene Derivatives; D010077:Oxazepines; D010080:Oxazoles; D023303:Oxazolidinones; D011725:Pyridines; C524146:benzyne; D014508:Urea