title: [(1)H-MRS study of auditory cortex in patients with presbycusis].
abstract: OBJECTIVE
  To study the metabolic changes of auditory cortex in patients with presbycusis by using proton magnetic resonance spectroscopy ((1)H-MRS).
  
  
  METHODS
  Ten normal hearing volunteers (youth group), 10 normal hearing of elderly (aged group) and 8 patients with presbycusis (presbycusis group) were checked with proton magnetic resonance spectroscopy. N-acetylaspartic acid (NAA), creatine (Cr), choline (Cho), γ-aminobutyric acid (GABA), glutamic acid (Glu) compound were measured. The differences between the groups were semi-quantitatively analyzed.
  
  
  RESULTS
  When compared with youth group, reduced NAA/Cr, increased Cho/Cr were found in the aged group and presbycusis group (P < 0.05). GABA/Cr ratio and Glu/Cr ratio were significant difference between presbycusis group and youth group (P < 0.05). There were no significant difference in the GABA/Cr and Glu/Cr ratios in the bilateral auditory cortex between the youth group and the aged group (P > 0.05). When compared with aged group, the metabolic changes of auditory cortex in patients with presbycusis were remarkable (P < 0.05).
  
  
  CONCLUSIONS
  (1)H-MRS is a noninvasive technique that can provide useful information concerning the metabolic changes of auditory cortex in human. In comparison to the aged group and the youth group, the changes of NAA, GABA, Cho and Glu is found in auditory cortex in patients with presbycusis.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Fuzhou General Hospital of People's Liberation Army, Fuzhou , China. fzchxming@sina.com
authors.forename: Xian-ming
authors.initials: XM
authors.lastname: Chen
authors.forename: Xiao-qing
authors.initials: XQ
authors.lastname: Dou
authors.forename: Yong-hui
authors.initials: YH
authors.lastname: Liang
authors.forename: Li-wei
authors.initials: LW
authors.lastname: Zhang
authors.forename: Bi-qiang
authors.initials: BQ
authors.lastname: Luo
authors.forename: Yi-hong
authors.initials: YH
authors.lastname: Deng
mesh_terms: D000328:Adult; D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001303:Auditory Cortex / Q000378:metabolism*; D016022:Case-Control Studies; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011304:Presbycusis / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline