title: [Therapeutic results of the treatment brain tumors using radiosurgery and stereotactic radiotherapy].
abstract: BACKGROUND
  We reviewed the results of treatment of patients treated with stereotactic radiation methods in our department.
  
  
  METHODS
  Patients with primary brain tumor or brain metastases underwent CT and MR examination. Then they were treated on X knife in the Clinic of Radiation Oncology in Masaryk Memorial Cancer Institute Brno.
  
  
  RESULTS
  A total of 101 patients with primary brain tumors underwent stereotactic treatment. These were mainly meningeomas, high-grade gliomas and low-grade gliomas. In 37% of cases patients underwent reiradiation. Stereotactic radiosurgery was applied with a median dose of 18 Gy. Hypofrakcionated stereotactic radiotherapy was applied at a doses of mostly 5 × 5 Gy. Total toxicity of treatment was low: 8% acute G1, late toxicity in 1% of cases. In the whole group achieved partial remission 10 patients (9,9%). One patient had complete remission (0,99%). It was a diagnosis of pituitary adenoma. In 69 patients stable disease was observed (68,3%) and 12 patients had progression (11,88%). Median follow up the entire group was 22,4 months. A statistically significant difference in survival was found in the comparison of different diagnosis, patients who received prior radiotherapy and patients without previous irradiation. Another significant difference in survival was observed compared to patients treated with stereotactic treatment or stereotactic radiosurgery and the size of the tumor volume larger / smaller 10 cm3. In the group with brain metastases there were 56 patients. In 10% of cases preceded radiotherapy neurosurgical performance. Twenty four patients underwent cranial irradiation entire dose of 30 Gy. Median stereotactic radiosurgery dose was 20 Gy, the application of stereotactic treatment were mostly of 5 × 5 Gy. G1 acute toxicity occurred in 2 patients (3.8%), grade G2 in one patient (1.9%). Late toxicity was observed in 2 patients (one G1 and one G3). Complete remission was achieved in 4 patients (7.1%), partial remission in 27 patients (48.2%), stable disease in 9 (16.1%) and progression was observed in 5 patients (8.9%). Median follow-up the entire group was 13.3 months. There was no statistically significant difference in survival with respect to gender, age, KI, irradiation of the whole brain or type of treatment used. Patients who have undergone neurosurgery prior to irradiation had no difference in survival compared to patients without surgery, but the time to progression was significantly longer (p = 0.016).
  
  
  CONCLUSIONS
  Stereotactic radiation methods are part of modern radiotherapy. Their indication is necessary to consider with regard to the benefit of the patient. Quality equipment radiotherapy department and trained personnel are the condition for their correct using.
authors.affiliation: Klinika radiacni onkologie LF MU a MOU Brno. dolezelova@mou.cz
authors.forename: H
authors.initials: H
authors.lastname: Doleželová
authors.forename: L
authors.initials: L
authors.lastname: Hynková
authors.forename: P
authors.initials: P
authors.lastname: Pospíšil
authors.forename: T
authors.initials: T
authors.lastname: Kazda
authors.forename: P
authors.initials: P
authors.lastname: Slampa
authors.forename: I
authors.initials: I
authors.lastname: Coupková
authors.forename: I
authors.initials: I
authors.lastname: Siková
authors.forename: P
authors.initials: P
authors.lastname: Fardus
authors.forename: T
authors.initials: T
authors.lastname: Svoboda
authors.forename: J
authors.initials: J
authors.lastname: Garčic
authors.forename: M
authors.initials: M
authors.lastname: Vrzal
authors.forename: I
authors.initials: I
authors.lastname: Selingerová
authors.forename: I
authors.initials: I
authors.lastname: Horová
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery