title: A general solid phase method for the synthesis of depsipeptides.
abstract: Herein we describe the synthesis of depsipeptide sequences in which the backbone is composed of alternating esters and amides. Our methodology is based on the synthesis and protection of a depsidipeptide block, which is used as the growing unit for manual SPPS. We have explored Fmoc/OBzl and Fmoc/tBu SPPS strategies, and found the latter to be most compatible with our methodology.
authors.affiliation: The University of Texas at Austin, Department of Biomedical Engineering, 107 W Dean Keeton Street, Austin, TX 78712, USA. m.nguyen@utexas.edu
authors.forename: Mary M
authors.initials: MM
authors.lastname: Nguyen
authors.forename: Nicole
authors.initials: N
authors.lastname: Ong
authors.forename: Laura
authors.initials: L
authors.lastname: Suggs
mesh_terms: D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019151:Peptide Library; D060327:Solid-Phase Synthesis Techniques
chemical_list: D047630:Depsipeptides; D019151:Peptide Library