title: Histological analysis of the effect of accelerated portland cement as a bone graft substitute on experimentally-created three-walled intrabony defects in dogs.
abstract: OBJECTIVE
  Recent literature shows that accelerated Portland cement (APC) is a non-toxic material that may have potential to promote bone healing. The objective of this study was to histologically evaluate periodontal healing focusing on new bone regeneration following implantation of APC into intra-bony defects in dogs.
  
  
  METHODS
  Three-wall intra-bony periodontal defects were surgically created at the mesial aspect of the first molar in both sides of mandible in six dogs. One side was randomly filled with the material and other received a flap operation only. The animals were euthanized eight weeks post-surgery when block sections of the defect sites were collected and prepared for qualitative histological analysis.
  
  
  RESULTS
  Compared to control group, stimulation of growth of new bone tissue in the cavity con-taining APC was significantly prominent in three of six cases, showing osteoid formation with osteoblastic rimming and new bone trabeculla. New bone formation was observed just close to cavity containing APC. Connective tissue proliferation and downgrowth of epithelium were signif-icantly less than those of control group.
  
  
  CONCLUSIONS
  Our results are encouraging for the use of APC as a bone substitute, but more comprehensive study are necessary before warranting clinical use.
authors.affiliation: Assistant Professor, Department of Periodontology, School of Dental Medicine, Shiraz University of Medical Sciences, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Dokami
authors.forename: Saeed
authors.initials: S
authors.lastname: Raoofi
authors.forename: Mohamad Javad
authors.initials: MJ
authors.lastname: Ashraf
authors.forename: Hooman
authors.initials: H
authors.lastname: Khorshidi
keywords: Accelerated Portland cement; bone substitutes; osteogenesis