title: Gene trees and species trees: irreconcilable differences.
abstract: BACKGROUND
  Reconciliation is the classical method for inferring a duplication and loss history from a set of extant genes. It is based upon the notion of embedding the gene tree into the species tree, the incongruence between the two indicating evidence for duplication and loss. However, results obtained by this method are highly dependent upon the considered species and gene trees. Thus, painstaking attention has been given to the development of methods for reconstructing accurate gene trees.
  
  
  RESULTS
  This paper highlights the fact that errors in gene trees are not the only reasons for the inference of an erroneous duplication-loss history. More precisely, we prove that, under certain reasonable hypotheses based on the widely accepted link between function and sequence constraints, even a well-supported gene tree yield a reconciliation that does not correspond to the true history. We then provide the theoretical underpinnings for a conservative approach to infer histories given such gene trees. We apply our method to the mammalian interleukin-1 (IL) gene tree, that has been used as a model example to illustrate the role of reconciliation.
authors.affiliation: Département d'Informatique, DIRO, Université de Montréal, H3C 3J7 Canada. swensonk@iro.umontreal.ca
authors.forename: Krister M
authors.initials: KM
authors.lastname: Swenson
authors.forename: Nadia
authors.initials: N
authors.lastname: El-Mabrouk
mesh_terms: D000465:Algorithms; D000818:Animals; D019143:Evolution, Molecular; D020440:Gene Duplication; D005796:Genes; D016678:Genome; D007375:Interleukin-1 / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA
chemical_list: D007375:Interleukin-1