title: The clinical ramifications of polycystic ovarian morphology in oocyte donors.
abstract: OBJECTIVE
  To determine the relationship between Polycystic Ovary (PCO) morphology and In Vitro Fertilization (IVF) outcome in oocyte donation cycles.
  
  
  METHODS
  Cross sectional study
  
  
  METHODS
  Private IVF clinic
  
  
  METHODS
  164 consecutive ovum donors and their recipients were reviewed, 149 were included in the study where 113 patients had normal ovarian morphology and 36 patients had PCO morphology.
  
  
  METHODS
  All donors underwent ovarian stimulation in conjunction with GnRH agonist or antagonist in standard fashion.
  
  
  METHODS
  Baseline donor characteristics were recorded, as well as details of IVF stimulation and embryo data. Recipient data on pregnancy and miscarriage were also collected.
  
  
  RESULTS
  Patients with PCO ovaries had significantly higher peak estradiol levels and required less gonadotropins during IVF stimulation. In addition, the baseline characteristics between donor groups did not differ except for ovarian morphology. The number of oocytes retrieved and indicators of embryo quality did not differ between the two groups, and there was no significant difference between pregnancy and miscarriage rates in the recipients.
  
  
  CONCLUSIONS
  Oocyte donors with PCO morphology have equivalent pregnancy rates and do not need to be excluded as potential donors.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California-Los Angeles, CA, USA. michele.cho@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Cho
authors.forename: G
authors.initials: G
authors.lastname: Ambartsumyan
authors.forename: H
authors.initials: H
authors.lastname: Danzer
authors.forename: K
authors.initials: K
authors.lastname: Brennan
authors.forename: M
authors.initials: M
authors.lastname: Surrey
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000008:administration & dosage / Q000819:agonists / Q000037:antagonists & inhibitors; D006801:Humans; D008875:Middle Aged; D018587:Oocyte Donation; D009865:Oocytes / Q000166:cytology / Q000254:growth & development*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000473:pathology / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D006062:Gonadotropins