title: Softwares and methods for estimating genetic ancestry in human populations.
abstract: The estimation of genetic ancestry in human populations has important applications in medical genetic studies. Genetic ancestry is used to control for population stratification in genetic association studies, and is used to understand the genetic basis for ethnic differences in disease susceptibility. In this review, we present an overview of genetic ancestry estimation in human disease studies, followed by a review of popular softwares and methods used for this estimation.
authors.affiliation: Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Liu
authors.forename: Toru
authors.initials: T
authors.lastname: Nyunoya
authors.forename: Shuguang
authors.initials: S
authors.lastname: Leng
authors.forename: Steven A
authors.initials: SA
authors.lastname: Belinsky
authors.forename: Yohannes
authors.initials: Y
authors.lastname: Tesfaigzi
authors.forename: Shannon
authors.initials: S
authors.lastname: Bruse
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005828:Genetics, Population / Q000379:methods*; D015894:Genome, Human; D006801:Humans; D015810:Linkage Disequilibrium; D008390:Markov Chains; D010375:Pedigree; D025341:Principal Component Analysis; D012984:Software