title: Design of the efficacy of prednisone in the treatment of ocular myasthenia (EPITOME) trial.
abstract: Efficacy of Prednisone in the Treatment of Ocular Myasthenia (EPITOME) is a multicenter, randomized, double blind, placebo-controlled trial that is being conducted under the auspices of the Muscle Study Group. EPITOME is the first randomized control trial in patients with ocular myasthenia and aims to evaluate the efficacy and tolerability of prednisone over a period of four months in patients with newly diagnosed ocular myasthenia whose symptoms have failed to remit in response to a trial of cholinesterase inhibitor therapy.
authors.affiliation: Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA. mbenatar@med.miami.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Benatar
authors.forename: Donald B
authors.initials: DB
authors.lastname: Sanders
authors.forename: Gil I
authors.initials: GI
authors.lastname: Wolfe
authors.forename: Michael P
authors.initials: MP
authors.lastname: McDermott
authors.forename: Rabi
authors.initials: R
authors.lastname: Tawil
mesh_terms: D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D004311:Double-Blind Method; D005128:Eye Diseases / Q000188:drug therapy*; D006801:Humans; D009157:Myasthenia Gravis / Q000188:drug therapy*; D010919:Placebos; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D002800:Cholinesterase Inhibitors; D010919:Placebos; D011241:Prednisone