title: Ovarian imaging by magnetic resonance in adolescent girls with polycystic ovary syndrome and age-matched controls.
abstract: OBJECTIVE
  To compare ovarian morphology in adolescent girls with and without polycystic ovary syndrome (PCOS) using magnetic resonance imaging (MRI).
  
  
  METHODS
  In 21 adolescent girls (age 12-18 years) without and 19 adolescents with PCOS (diagnosis based on excessive hair growth and irregular menstrual cycles) ovarian volume, antral follicle count (AFC) per ovary, and follicle size were evaluated. MRI was performed at 1.5 T or 3 T and axial or angled-axial single-shot echo-train spin echo images of 6 mm slice thickness were acquired. In a subset of subjects, 2-mm images were also obtained. PCOS and non-PCOS groups were compared using mixed affects regression.
  
  
  RESULTS
  Mean AFC per ovary and ovarian volume were substantially greater in PCOS subjects compared to non-PCOS subjects. Mean follicle size was similar between groups. Follicles exceeding 10 mm were seen in 2/19 PCOS subjects versus 9/21 non-PCOS subjects. Consistently higher follicle counts were detected in images obtained at 2 mm compared to 6-mm slice thickness.
  
  
  CONCLUSIONS
  In adolescence, MRI of the ovary reveals distinct differences between girls with and without PCOS. MRI may help evaluate young patients in whom transvaginal ultrasound is contraindicated.
authors.affiliation: Department of Radiology, University of California, San Diego, La Jolla, California 92093, USA.
authors.forename: Michele
authors.initials: M
authors.lastname: Brown
authors.forename: Alice S
authors.initials: AS
authors.lastname: Park
authors.forename: Rana F
authors.initials: RF
authors.lastname: Shayya
authors.forename: Tanya
authors.initials: T
authors.lastname: Wolfson
authors.forename: H Irene
authors.initials: HI
authors.lastname: Su
authors.forename: R Jeffrey
authors.initials: RJ
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000465:Algorithms; D002648:Child; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010053:Ovary / Q000473:pathology*; D011085:Polycystic Ovary Syndrome / Q000473:pathology*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: magnetic resonance; ovarian follicles; polycystic ovary syndrome