title: Phyto-power dietary supplement potently inhibits dimethylnitrosamine-induced liver fibrosis in rats.
abstract: Curcumin has been extensively studied for its therapeutic effects in a variety of disorders. Fermented soy consumption is associated with a low incidence rate of chronic diseases in many Asian countries. The aim of this study was to investigate the potential underlying mechanisms of the effect of a phyto-power dietary supplement on liver fibrosis. Sprague-Dawley rats were intraperitoneally injected with dimethylnitrosamine (DMN; 10 mg kg(-1)) three times a week for four consecutive weeks. A phyto-power dietary supplement (50 or 100 mg kg(-1)) was administered by oral gavage daily for four weeks. Liver morphology, function, and fibrotic status were examined in DMN induced hepatic fibrogenesis. However, a phyto-power dietary supplement alleviated liver damage as indicated by histopathological examination of the α-smooth muscle actin (α-SMA) and collagen I, accompanied by the concomitant reduction of transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase 2 (MMP2). These data indicate that the phyto-power dietary supplement may inhibit the TGF-β1/Smad signaling and relieve liver damage in experimental fibrosis.
authors.affiliation: Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan.
authors.forename: Ming-Fen
authors.initials: MF
authors.lastname: Lee
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Tsai
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Sun
authors.forename: Ling-Lung
authors.initials: LL
authors.lastname: Chien
authors.forename: An-Chin
authors.initials: AC
authors.lastname: Cheng
authors.forename: Nianhan Jia-Lin
authors.initials: NJ
authors.lastname: Ma
authors.forename: Chi-Tang
authors.initials: CT
authors.lastname: Ho
authors.forename: Min-Hsiung
authors.initials: MH
authors.lastname: Pan
mesh_terms: D000199:Actins / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D003094:Collagen / Q000378:metabolism; D003474:Curcumin / Q000494:pharmacology*; D019587:Dietary Supplements; D004128:Dimethylnitrosamine / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D051899:Smad2 Protein / Q000378:metabolism; D051900:Smad3 Protein / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D000199:Actins; D003094:Collagen; D003474:Curcumin; D004128:Dimethylnitrosamine; D020778:Matrix Metalloproteinase 2; D051899:Smad2 Protein; D051900:Smad3 Protein; D053773:Transforming Growth Factor beta1; C497784:Smad2 protein, rat; C497787:Smad3 protein, rat; C498862:Acta2 protein, rat; C522363:Mmp2 protein, rat