title: Bifunctional nanoparticles constructed using one-pot encapsulation of a fluorescent polymer and magnetic (Fe3O4) nanoparticles in a silica shell.
abstract: Integration of biocompatible silica with a fluorescent polymer (PDDF) and superparamagnetic iron oxide nanoparticles (Fe3 O4 ) to form uniform core-shell nanostructures has the great potential to form particles for use in multimodal bioimaging applications. Core-shell nanoparticles (PDDF/Fe3 O4 @SiO2 ) exhibit fluorescent and magnetic properties that are favorable for their use in magnetic separation and guiding applications, as well as optical and magnetic resonance (MR) imaging capabilities. With the biological analysis in an in vitro intracellular permeation and cytotoxicity test, chemical conjugation of the surface using folic acid (FA) molecules can provide the nanoparticles with cell-targeting properties, localizing the nanoparticles to folate receptors (FRs) on target KB cells that over-express the FRs.
authors.affiliation: BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahangno, Yuseong-gu, Daejeon 305-806, Korea.
authors.forename: Chang-Soo
authors.initials: CS
authors.lastname: Lee
authors.forename: Hee Hyun
authors.initials: HH
authors.lastname: Chang
authors.forename: Pan-Kee
authors.initials: PK
authors.lastname: Bae
authors.forename: Juyeon
authors.initials: J
authors.lastname: Jung
authors.forename: Bong Hyun
authors.initials: BH
authors.lastname: Chung
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004339:Drug Compounding; D016503:Drug Delivery Systems; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D005449:Fluorenes / Q000737:chemistry*; D058975:Folate Receptor 1 / Q000378:metabolism; D005492:Folic Acid / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007624:KB Cells; D058185:Magnetite Nanoparticles / Q000737:chemistry; D057054:Molecular Imaging / Q000379:methods; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D005449:Fluorenes; D058975:Folate Receptor 1; D058185:Magnetite Nanoparticles; D011108:Polymers; D012822:Silicon Dioxide; D005492:Folic Acid; D052203:Ferrosoferric Oxide