title: Making healthy stem cells: the new role of TPO.
abstract: Thrombopoietin (TPO) attracts much attention as an effective stimulus for blood cell formation in patients with hematopoietic disorders. In this issue of Cell Stem Cell, de Laval et al. (2013) show that TPO can also promote "healthy" hematopoietic stem cells when administered before radiotherapy to minimize HSC injury and mutagenesis in mice.
authors.affiliation: Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Susumu
authors.initials: S
authors.lastname: Goyama
authors.forename: James C
authors.initials: JC
authors.lastname: Mulloy
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000502:physiology*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D008297:Male; D016296:Mutagenesis / Q000502:physiology*; D013234:Stem Cells / Q000378:metabolism*; D013926:Thrombopoietin / Q000378:metabolism*
chemical_list: D013926:Thrombopoietin