title: Voxel-based imaging of translocator protein 18 kDa (TSPO) in high-resolution PET.
abstract: In vivo imaging of translocator protein 18 kDa (TSPO) has received significant attention as potential biomarker of microglia activation. Several radioligands have been designed with improved properties. Our group recently developed an (18)F-labeled TSPO ligand, [(18)F]-FEPPA, and confirmed its reliability with a 2-tissue compartment model. Here, we extended, in a group of healthy subjects, its suitability for use in voxel-based analysis with the newly proposed graphical analysis approach, Relative-Equilibrium-Gjedde-Patlak (REGP) plot. The REGP plot successfully replicated the total distribution volumes estimated by the 2-tissue compartment model. We also showed its proof-of-concept in a patient with possible meningioma showing increased [(18)F]-FEPPA total distribution volume.
authors.affiliation: Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Ko
authors.forename: Yuko
authors.initials: Y
authors.lastname: Koshimori
authors.forename: Romina
authors.initials: R
authors.lastname: Mizrahi
authors.forename: Pablo
authors.initials: P
authors.lastname: Rusjan
authors.forename: Alan A
authors.initials: AA
authors.lastname: Wilson
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Lang
authors.forename: Sylvain
authors.initials: S
authors.lastname: Houle
authors.forename: Antonio P
authors.initials: AP
authors.lastname: Strafella
mesh_terms: D000368:Aged; D000813:Anilides / Q000008:administration & dosage*; D015415:Biomarkers / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008579:Meningioma / Q000000981:diagnostic imaging / Q000378:metabolism; D017628:Microglia / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D011725:Pyridines / Q000008:administration & dosage*; D011859:Radiography; D018079:Receptors, GABA / Q000378:metabolism*
chemical_list: D000813:Anilides; D015415:Biomarkers; C530438:N-(2-((N-(4-phenoxypyridin-3-yl)acetamido)methyl)phenoxy)ethyl fluoride; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D011725:Pyridines; D018079:Receptors, GABA; C499229:TSPO protein, human