title: Estimating the incidence of colorectal cancer in Sub-Saharan Africa: A systematic analysis.
abstract: BACKGROUND
  Nearly two-thirds of annual mortality worldwide is attributable to non-communicable diseases (NCDs), with 70% estimated to occur in low- and middle-income countries (LMIC). Colorectal cancer (CRC) accounts for over 600 000 deaths annually, but data concerning cancer rates in LMIC is very poor. This study analyses the data available to produce an estimate of the incidence of colorectal cancer in Sub-Saharan Africa (SSA).
  
  
  METHODS
  DATA FOR THIS ANALYSIS CAME FROM TWO MAIN SOURCES: a systematic search of Medline, EMBASE and Global Health which found 15 published data sets, and an additional 42 unpublished data sets which were sourced from the IARC and individual cancer registries. Data for case rates by age and sex, as well as population denominators were extracted and analysed to produce an estimate of incidence.
  
  
  RESULTS
  The crude incidence of CRC in SSA for both sexes was found to be 4.04 per 100 000 population (4.38 for men and 3.69 for women). Incidence increased with age with the highest rates in Southern Africa, particularly in South Africa. The rates of CRC in SSA were much lower than those reported for high-income countries.
  
  
  CONCLUSIONS
  Few health services in SSA are equipped to provide timely diagnosis and treatment of cancer in SSA. In addition, data collection systems are weak, meaning that the available statistics may underestimate the burden of disease. In order to improve health care services it is vital that accurate measurements of disease burden are available to policy makers.
authors.affiliation: Centre for Population Health Sciences and Global Health Academy, The University of Edinburgh Medical School, Edinburgh, Scotland, UK.
authors.forename: Alice
authors.initials: A
authors.lastname: Graham
authors.forename: Davies
authors.initials: D
authors.lastname: Adeloye
authors.forename: Liz
authors.initials: L
authors.lastname: Grant
authors.forename: Evropi
authors.initials: E
authors.lastname: Theodoratou
authors.forename: Harry
authors.initials: H
authors.lastname: Campbell