title: Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery.
abstract: A stable drug carrier has been prepared by covalently coating magnetic nanoparticles (MNPs) with PEO-PPO-PEO block copolymer Pluronic P85. The particles were characterized by TEM, XRD, DLS, VSM, FTIR, and TGA. A typical product has a 15 nm magnetite core and a 100 nm hydrodynamic diameter with a narrow size distribution and is superparamagnetic with large saturation magnetization (57.102 emu/g) at room temperature. The covalently-coated Pluronic-MNPs (MagPluronics) were proven to be stable in different conditions, such as aqueous solution, 0.2 M PBS solution, and pH 13.5 solution, which would be significant for biological applications. Furthermore, MagPluronics also possess temperature-responsive property acquired from the Pluronic copolymer layer on their surface, which can cause conformational change of Pluronics and improve load and delivery efficiency of the particles. The temperature-controlled loading and releasing of hydrophobic model drug curcumin were tested with these particles. A loading efficiency of 81.3% and a sustained release of more than 4 days were achieved in simulated human body condition. It indicates that the covalently-coated MagPluronics are stable carriers with good drug-loading capacity and controlled-release property.
authors.affiliation: Laboratory of Separation Science and Engineering, State Key Laboratory of Biochemical Engineering, Chinese Academy of Sciences, Beijing 100190, China. wangning061091@gmail.com
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Yueping
authors.initials: Y
authors.lastname: Guan
authors.forename: Liangrong
authors.initials: L
authors.lastname: Yang
authors.forename: Lianwei
authors.initials: L
authors.lastname: Jia
authors.forename: Xuetuan
authors.initials: X
authors.lastname: Wei
authors.forename: Huizhou
authors.initials: H
authors.lastname: Liu
authors.forename: Chen
authors.initials: C
authors.lastname: Guo
mesh_terms: D016503:Drug Delivery Systems; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011060:Poloxalene / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D013499:Surface Properties
chemical_list: C116176:PEO-PPO-PEO; D011409:Propylene Glycols; C422648:pluronic block copolymer p85; D011092:Polyethylene Glycols; D011060:Poloxalene