title: Effect of early postnatal neutropenia in very low birth weight infants born to mothers with pregnancy-induced hypertension.
abstract: OBJECTIVE
  In this study, we aimed to investigate the perinatal clinical conditions of very low birth weight (VLBW) infants born to mothers with pregnancy-induced hypertension (PIH) focusing on the effects of early postnatal neutropenia.
  
  
  METHODS
  We reviewed the medical records of 191 VLBW infants who were born at Konyang University Hospital, between March 2003 and May 2011. We retrospectively analyzed the clinical characteristics of the infants and their mothers and compared the incidence of perinatal diseases and mortality of the infants according to the presence or absence of maternal PIH and neutropenia on the first postnatal day.
  
  
  RESULTS
  Infants born to mothers with PIH showed an increased incidence of neutropenia on the first postnatal day (47.4%), cesarean delivery, and intrauterine growth restriction. When the infants born to mothers with PIH showed neutropenia on the first postnatal day, their incidence of respiratory distress syndrome (RDS) was increased (P=0.031); however, the difference was not found to be significant through logistic regression analysis. In all the VLBW infants, neutropenia on the first postnatal day was correlated with the development of RDS. The incidence of the other perinatal diseases involving sepsis and mortality did not significantly differ according to the presence or absence of neutropenia in infants born to mothers with PIH.
  
  
  CONCLUSIONS
  In VLBW infants born to mothers with PIH, the incidence of neutropenia on the first postnatal day was increased and it was not significantly correlated with the development of perinatal diseases involving RDS, sepsis, and mortality.
authors.affiliation: Department of Pediatrics, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Yang Hee
authors.initials: YH
authors.lastname: Park
authors.forename: Gyung Min
authors.initials: GM
authors.lastname: Lee
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Yoon
authors.forename: Enn Jung
authors.initials: EJ
authors.lastname: Cheon
authors.forename: Kyung Ok
authors.initials: KO
authors.lastname: Ko
authors.forename: Yung Hyuk
authors.initials: YH
authors.lastname: Lee
authors.forename: Jae Woo
authors.initials: JW
authors.lastname: Lim
keywords: Neutropenia; Perinatal diseases; Pregnancy-induced hypertension; Preterm infants; Very low birth weight