title: Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.
abstract: Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines.
authors.affiliation: Department of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India. sashidhar123@gmail.com
authors.forename: Koneni V
authors.initials: KV
authors.lastname: Sashidhara
authors.forename: Srinivasa Rao
authors.initials: SR
authors.lastname: Avula
authors.forename: Komal
authors.initials: K
authors.lastname: Sharma
authors.forename: Gopala Reddy
authors.initials: GR
authors.lastname: Palnati
authors.forename: Surendar Reddy
authors.initials: SR
authors.lastname: Bathula
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013871:Thiones / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D011743:Pyrimidines; D013871:Thiones; C400223:monastrol; C030123:coumarin