title: Anticancer and antimicrobial activity of mangrove derived fungi Hypocrea lixii VB1.
abstract: OBJECTIVE
  Mangrove is one of the oldest living tree species and its leaves are among the most extensively studied botanicals in use today. Scientific research throughout the world has found evidence to support the fact that its foliar extracts have great potential against human microbial pathogens. This study highlights the isolation of foliar fungi from Rhizophora mucronata, Avicenna officialis and Avicenna marina.
  
  
  METHODS
  It was isolated in Sabouroud's Dextrose Agar and mass cultivation was done in Sabouroud's Dextrose broth.
  
  
  RESULTS
  The ethyl acetate extract showed maximum antibacterial activity which inturn checked for different concentration against bacterial pathogens and anticancer activity for Hep2 and MCF7 cell line in vitro. The DNA was isolated from the fungi and the ITS region of 5.8 s RNA was sequenced and assigned to new species as they are separated from the type strains phylogenetic neighbors by sequence similarities.
  
  
  CONCLUSIONS
  This preliminary screening of fungal endophytes revealed their potential to yield potent bioactive compounds for drug discovery programmes.
authors.affiliation: Department of Biotechnology, Sathyabama University, Chennai-600 119, India. bvbhimba@yahoo.co.in
authors.forename: B Valentin
authors.initials: BV
authors.lastname: Bhimba
authors.forename: D A
authors.initials: DA
authors.lastname: Agnel Defora Franco
authors.forename: Jibi Merin
authors.initials: JM
authors.lastname: Mathew
authors.forename: Geena Mary
authors.initials: GM
authors.lastname: Jose
authors.forename: Elsa Lycias
authors.initials: EL
authors.lastname: Joel
authors.forename: M
authors.initials: M
authors.lastname: Thangaraj
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D032407:Avicennia / Q000382:microbiology*; D001483:Base Sequence; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004271:DNA, Fungal; D060026:Endophytes; D006801:Humans; D035901:Hypocrea / Q000235:genetics; D061986:MCF-7 Cells; D009369:Neoplasms / Q000188:drug therapy*; D010802:Phylogeny; D008517:Phytotherapy; D019244:RNA, Satellite; D043982:Rhizophoraceae / Q000382:microbiology*; D013045:Species Specificity
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D004271:DNA, Fungal; D019244:RNA, Satellite