title: Decreased serum paraoxonase activity in patients with chronic pancreatitis.
abstract: BACKGROUND
  Recent evidences suggest that oxidative stress is involved in the mechanism of chronic pancreatitis (CP). Paraoxonase 1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of our study is to investigate whether serum PON1 activity is associated with the presence of CP.
  
  
  METHODS
  A total of 186 patients with alcoholic CP and 132 healthy subjects were enrolled in this study. Serum PON1 activity was measured using paraoxon as a substrate.
  
  
  RESULTS
  Serum PON1 activity was significantly decreased in CP patients compared with healthy subjects. Multivariable logistic regression analysis revealed that serum PON1 activity was a determinant of the presence of CP (OR = 0.992, 95% CI = 0.987-0.998; P = 0.006).
  
  
  CONCLUSIONS
  Decreased serum PON1 activity may be considered as a predicting marker of the presence of CP.
authors.affiliation: Department of Thoracic Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, P.R. China.
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.forename: Benrui
authors.initials: B
authors.lastname: Lin
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D050500:Pancreatitis, Chronic / Q000097:blood* / Q000209:etiology* / Q000503:physiopathology; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D043303:Aryldialkylphosphatase