title: Effect of return to overuse activity following an isolated supraspinatus tendon tear on adjacent intact tendons and glenoid cartilage in a rat model.
abstract: Rotator cuff tears are common conditions that can alter shoulder mechanics and may lead to damage of intact joint tissues. These injuries are of particular concern in populations who perform tasks requiring repetitive overhead activity (e.g., athletes and laborers) and who are likely to return to aggressive pre-injury activity levels despite limited understanding of the potentially damaging effects on the remaining tissues. Therefore, we investigated the effect of returning to overuse activity following a supraspinatus tear on shoulder function and the mechanical properties of the remaining intact tendons and glenoid cartilage. Forty rats underwent 4 weeks of overuse activity to create a tendinopathic condition followed by detachment of the supraspinatus tendon and were then randomized into two groups: continued overuse or cage activity. Ambulatory measurements were performed throughout the 8 weeks prior to euthaniasia, and properties of the adjacent tendons and cartilage were evaluated. Results demonstrated that shoulder function was not compromised in the return to overuse group. However, alterations of the glenoid cartilage and biceps tendon properties occurred. Our results help define the contributory roles of common mechanical injury mechanisms and provide a framework by which physicians could better prescribe long-term treatment strategies for patients.
authors.affiliation: McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 424 Stemmler Hall 36th Street and Hamilton Walk, Philadelphia, PA, USA.
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Reuther
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Thomas
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Sarver
authors.forename: Jennica J
authors.initials: JJ
authors.lastname: Tucker
authors.forename: Chang-Soo
authors.initials: CS
authors.lastname: Lee
authors.forename: Chancellor F
authors.initials: CF
authors.lastname: Gray
authors.forename: David L
authors.initials: DL
authors.lastname: Glaser
authors.forename: Louis J
authors.initials: LJ
authors.lastname: Soslowsky
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena / Q000502:physiology; D012090:Cumulative Trauma Disorders / Q000503:physiopathology*; D004195:Disease Models, Animal; D004548:Elasticity / Q000502:physiology; D061165:Glenoid Cavity / Q000503:physiopathology*; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017006:Rotator Cuff / Q000503:physiopathology*; D000070636:Rotator Cuff Injuries; D012420:Running / Q000502:physiology; D012785:Shoulder Joint / Q000503:physiopathology*; D013708:Tendon Injuries / Q000503:physiopathology*