title: Histiocytic necrotizing lymphadenitis in children: a clinical and immunohistochemical comparative study with adult patients.
abstract: OBJECTIVE
  Limited information is available regarding the characteristics of histiocytic necrotizing lymphadenitis (HNL) in children. This study compares the clinical and laboratory features as well as the immunohistochemical findings of HNL in children with those of adults.
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  Thirty patients who underwent a biopsy of a cervical lymph node and were histologically proven to have HNL were enrolled in this study. There were 13 children and 17 adults. CD68, CD163 and myeloperoxidase expression were analyzed by immunohistochemical staining.
  
  
  RESULTS
  Children had more bilateral lymphadenopathy (P=0.045) and a higher expression of CD68 (P=0.043) than did the adult patients. However, there was no significant difference between the groups in the following variables: patient gender, presence of fever, size and necrosis of enlarged lymph node, multiplicity of lymphadenopathy, WBC count, ESR, CRP, recurrence, and expression of myeloperoxidase and CD163.
  
  
  CONCLUSIONS
  The clinical and immunohistological characteristics of HNL in pediatric patients are similar to those of adults. Bilateral involvement of lymph nodes and a high expression of CD68 were the only features significantly associated with children with HNL.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Seo
authors.forename: Jun-Myung
authors.initials: JM
authors.lastname: Kang
authors.forename: HeeJeong
authors.initials: H
authors.lastname: Lee
authors.forename: WeonSun
authors.initials: W
authors.lastname: Lee
authors.forename: Se-Hwan
authors.initials: SH
authors.lastname: Hwang
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Joo
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001706:Biopsy; D002648:Child; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D012189:Retrospective Studies; D055815:Young Adult; D000098902:CD163 Antigen; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009195:Peroxidase; D011956:Receptors, Cell Surface; D000098902:CD163 Antigen; C067980:CD68 antigen, human; D000097382:CD68 Molecule