title: [Epithelial-bacterial interactions as a basis of microbiocenosis formation].
abstract: OBJECTIVE
  Evaluate significance of epithelial-bacterial interactions for the formation and/or support of microbiocenoses.
  
  
  METHODS
  Effect of vaginal epitheliocytes on growth properties of lactobacilli strains obtained from the same biotope from 16 women with vaginal normocenosis was studied. During intravaginal probiotic therapy in 24 women with vaginal dysbiosis probability of colonization of vagina by probiotic strain was evaluated depending on the result of effect of vaginal epitheliocytes on its growth properties.
  
  
  RESULTS
  Exometabolites of epitheliocytes in normocenosis were shown to render stimulating effect on the growth of autostrain of dominant microflora, that probably is the basis of formation and/or support of microbiocenosis. Stimulating effect of exometabolites of vaginal epitheliocytes of patients on growth properties of probiotic strain was revealed to be the prerequisite for successful probiotic therapy.
  
  
  CONCLUSIONS
  The data obtained allow to examine epithelial-bacterial interactions as a basis of formation of microbiocenoses. Evaluation of these interactions may be used for individual selection of probiotic strains.
authors.forename: E A
authors.initials: EA
authors.lastname: Kremleva
authors.forename: S V
authors.initials: SV
authors.lastname: Cherkasov
authors.forename: O V
authors.initials: OV
authors.lastname: Bukharin
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D058491:Bacterial Load; D002452:Cell Count; D002478:Cells, Cultured; D017077:Culture Media, Conditioned / Q000494:pharmacology; D016207:Cytokines / Q000096:biosynthesis / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism / Q000382:microbiology*; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects* / Q000502:physiology; D019936:Probiotics / Q000008:administration & dosage; D013559:Symbiosis / Q000502:physiology*; D014621:Vagina / Q000382:microbiology* / Q000502:physiology
chemical_list: D017077:Culture Media, Conditioned; D016207:Cytokines