title: Neolignans from leaves of Miliusa mollis.
abstract: From the leaves of Miliusa mollis Pierre (Annonaceae), five new dihydrobenzofuran neolignans, namely miliumollin, 7-methoxymiliumollin, 3'-methoxymiliumollin, 4'-O-methylmiliumollin and miliumollinone, and a new 8-O-4' neolignan named miliusamollin were isolated, and their structures were elucidated through analysis of spectroscopic data. Miliumollin, 3'-methoxymiliumollin, miliumollinone and decurrenal exhibited weak cytotoxicity against KB, MCF7 and NCI-H187 cells. Miliumollinone possessed weak inhibitory effects against herpes simplex virus types 1 and 2. None of the isolates displayed inhibitory activity against avian influenza H5N1 neuraminidase.
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Kanokporn
authors.initials: K
authors.lastname: Sawasdee
authors.forename: Tanawat
authors.initials: T
authors.lastname: Chaowasku
authors.forename: Vimolmas
authors.initials: V
authors.lastname: Lipipun
authors.forename: Thi-Hanh
authors.initials: TH
authors.lastname: Dufat
authors.forename: Sylvie
authors.initials: S
authors.lastname: Michel
authors.forename: Kittisak
authors.initials: K
authors.lastname: Likhitwitayawuid
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D000998:Antiviral Agents / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000302:isolation & purification*; D061986:MCF-7 Cells; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D017705:Lignans