title: Obesity and bone.
abstract: Recent studies indicate that fractures in obese postmenopausal women and older men contribute significantly to the overall fracture burden. The effect of obesity is to some extent site-dependent, the risk being increased for some fractures and decreased for others, possibly related to different patterns of falling and the presence or absence of soft tissue padding. Risk factors for fracture in obese individuals appear to be similar to those in the nonobese population, although falls may be particularly important in the obese. There is some evidence that the morbidity associated with fractures in obese individuals is greater than in the nonobese; however, a recent study indicates that the mortality associated with fracture is lower in obese and overweight people than in those of normal weight. The evidence base for strategies to prevent fractures in obese individuals is weak and is an important area for future research.
authors.affiliation: Department of Medicine, Addenbrooke's Hospital, Box 157, Level 5, Hills Road, Cambridge CB2 0QQ, UK. jec1001@cam.ac.uk
authors.forename: Juliet
authors.initials: J
authors.lastname: Compston
mesh_terms: D000367:Age Factors; D015992:Body Mass Index; D019468:Disease Management; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000503:physiopathology; D058866:Osteoporotic Fractures / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D012307:Risk Factors