title: CD133+ cancer stem cells in lung cancer.
abstract: Lung cancer is the most preventable cancer worldwide but has a poor prognosis. Recent advances in the study of lung cancer stem cell (CSC) populations has led to a growing recognition of the central importance of cells with stem cell-like properties in lung tumorigenesis. High number of CD133+ cells is associated with the maintenance, metastasis and drug-resistance of lung cancer. CD133 serves as a stemness biomarker for CD133+ CSCs, which have been found in lung cancer tissues. This article reviews the major studies supporting the existence and importance of CD133+ CSCs in the maintenance, metastasis and drug resistance of lung cancer. Continued research in the field of CD133+ CSCs biology is vital, as ongoing efforts promise to yield new prognostic and therapeutic targets.
authors.affiliation: Department of Oncology Part II, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, Xuhui District, Shanghai City, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Zhen Ye
authors.initials: ZY
authors.lastname: Xu
authors.forename: Li Fang
authors.initials: LF
authors.lastname: Wang
authors.forename: Wan
authors.initials: W
authors.lastname: Su
mesh_terms: D000071916:AC133 Antigen; D000230:Adenocarcinoma / Q000473:pathology; D015703:Antigens, CD / Q000502:physiology*; D014408:Biomarkers, Tumor; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D035683:MicroRNAs / Q000502:physiology; D009362:Neoplasm Metastasis / Q000517:prevention & control; D014411:Neoplastic Stem Cells / Q000473:pathology*; D050814:Octamer Transcription Factor-3 / Q000235:genetics; D010455:Peptides / Q000502:physiology*; D011379:Prognosis; D055752:Small Cell Lung Carcinoma / Q000473:pathology
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D006023:Glycoproteins; C541010:MIRN145 microRNA, human; D035683:MicroRNAs; D050814:Octamer Transcription Factor-3; C000606023:PROM1 protein, human; D010455:Peptides