title: Self-reported side effects of breast cancer treatment: a cross-sectional study of incidence, associations, and the influence of exercise.
abstract: OBJECTIVE
  Side effects as a result of breast cancer treatment may have a lasting detrimental impact on quality of life. Exercise has been shown to be an effective intervention in post-treatment care. This study aimed to gain a better understanding of breast cancer treatment-related side effects through identifying potential patient characteristic associations, including current levels of exercise.
  
  
  METHODS
  Four hundred and thirty-two breast cancer patients completed an online survey covering their treatment and demographic background, current exercise levels, and self-reported treatment side effects. Side effects were considered in a binary logistic regression against age, surgery, currently undergoing treatment, and exercise levels to ascertain significant relationships (p < 0.05) and associative values (Odds Ratio).
  
  
  RESULTS
  Lumpectomy patients were less likely to report aching muscles (OR 0.61, 95 % CI 0.39-0.96), hot flushes (OR 0.60, 95 % CI 0.38-0.96), and weight gain (OR 0.59, 95 % CI 0.38-0.92) than mastectomy patients. Women currently undergoing treatment were more likely to report hot flushes (OR 3.77, 95 % CI 2.34-6.08), aching muscles (OR 1.62, 95 % CI 1.02-2.57), and weight gain (OR 1.89, 95 % CI 1.19-2.99) than women finished treatment. Sedentary women were more likely to experience shoulder limitations (OR 1.77, 95 % CI 1.14-2.77), muscular chest wall pain (OR 1.69, 95 % CI 1.07-2.65), weight gain (OR 2.29, 95 % CI 1.44-3.64), lymphedema (OR 1.68, 95 % CI 1.04-2.71), and breathlessness (OR 2.30 95 % CI 1.35-3.92) than their physically active counterparts.
  
  
  CONCLUSIONS
  Patient characteristics may inform interventions to improve care post-breast cancer treatment. Sufficient levels of exercise were consistently associated fewer side effects and should be encouraged.
authors.affiliation: Biomechanics Research Laboratory, School of Health Sciences, University of Wollongong, Wollongong, NSW 2522, Australia. sg490@uowmail.edu.au
authors.forename: Sheridan A
authors.initials: SA
authors.lastname: Gho
authors.forename: Julie R
authors.initials: JR
authors.lastname: Steele
authors.forename: Sandra C
authors.initials: SC
authors.lastname: Jones
authors.forename: Bridget J
authors.initials: BJ
authors.lastname: Munro
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000523:psychology* / Q000628:therapy*; D003430:Cross-Sectional Studies; D003625:Data Collection; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology / Q000523:psychology; D015444:Exercise / Q000523:psychology*; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D015412:Mastectomy, Segmental / Q000009:adverse effects; D008875:Middle Aged; D011788:Quality of Life; D011878:Radiotherapy / Q000009:adverse effects; D057566:Self Report; D055815:Young Adult