title: Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.
abstract: Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid decreases the enzymatic activity of CD45 phosphatase significantly more than hydrogen peroxide. Our molecular docking computational analysis suggests that peroxytetradecanoic acid has a higher binding affinity to the catalytic center of CD45 than hydrogen peroxide.
authors.affiliation: Department of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland. alicjakuban@gumed.edu.pl
authors.forename: Alicja
authors.initials: A
authors.lastname: Kuban-Jankowska
authors.forename: Jack A
authors.initials: JA
authors.lastname: Tuszynski
authors.forename: Philip
authors.initials: P
authors.lastname: Winter
authors.forename: Magdalena
authors.initials: M
authors.lastname: Gorska
authors.forename: Narcyz
authors.initials: N
authors.lastname: Knap
authors.forename: Michal
authors.initials: M
authors.lastname: Wozniak
mesh_terms: D002264:Carboxylic Acids / Q000378:metabolism; D020134:Catalytic Domain; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism* / Q000494:pharmacology*; D017493:Leukocyte Common Antigens / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D062105:Molecular Docking Simulation; D019814:Myristic Acid / Q000378:metabolism* / Q000494:pharmacology*; D009227:Myristic Acids / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D002264:Carboxylic Acids; D004791:Enzyme Inhibitors; D009227:Myristic Acids; C581968:peroxytetradecanoic acid; D019814:Myristic Acid; D006861:Hydrogen Peroxide; D017493:Leukocyte Common Antigens