title: Mondia whitei (Periplocaceae) prevents and Guibourtia tessmannii (Caesalpiniaceae) facilitates fictive ejaculation in spinal male rats.
abstract: BACKGROUND
  Mondia whitei and Guibourtia tessmannii are used in Cameroon traditional medicine as aphrodisiacs. The present study was undertaken to evaluate the pro-ejaculatory effects of the aqueous and organic solvent extracts of these plants in spinal male rats.
  
  
  METHODS
  In spinal cord transected and urethane-anesthetized rats, two electrodes where inserted into the bulbospongiosus muscles and the ejaculatory motor pattern was recorded on a polygraph after urethral and penile stimulations, intravenous injection of saline (0.1 ml/100 g), dopamine (0.1 μM/kg), aqueous and organic solvent plant extracts (20 mg/kg).
  
  
  RESULTS
  In all spinal rats, urethral and penile stimulations always induced the ejaculatory motor pattern. Aqueous or hexane extract of Mondia whitei (20 mg/kg) prevented the expression of the ejaculatory motor pattern. The pro-ejaculatory effects of dopamine (0.1 μM/kg) were not abolished in spinal rats pre-treated with Mondia whitei extracts. Aqueous and methanolic stem bark extracts of Guibourtia tessmannii (20 mg/kg) induced fictive ejaculation characterized by rhythmic contractions of the bulbospongiosus muscles followed sometimes with expulsion of seminal plugs. In rats pre-treated with haloperidol (0.26 μM/kg), no ejaculatory motor pattern was recorded after intravenous injection of Guibourtia tessmannii extracts (20 mg/kg).
  
  
  CONCLUSIONS
  These results show that Mondia whitei possesses preventive effects on the expression of fictive ejaculation in spinal male rats, which is not mediated through dopaminergic pathway; on the contrary, the pro-ejaculatory activities of Guibourtia tessmannii require the integrity of dopaminergic system to exert its effects. The present findings further justify the ethno-medicinal claims of Mondia whitei and Guibourtia tessmannii.
authors.affiliation: Animal Physiology and Phytopharmacology Laboratory, University of Dschang, Cameroon. pwatcho@yahoo.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Watcho
authors.forename: Patrick Brice Deeh
authors.initials: PB
authors.lastname: Defo
authors.forename: Modeste
authors.initials: M
authors.lastname: Wankeu-Nya
authors.forename: Miguel
authors.initials: M
authors.lastname: Carro-Juarez
authors.forename: Telesphore Benoît
authors.initials: TB
authors.lastname: Nguelefack
authors.forename: Albert
authors.initials: A
authors.lastname: Kamanyi
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism* / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004542:Ejaculation / Q000187:drug effects* / Q000502:physiology; D007887:Fabaceae; D006220:Haloperidol / Q000494:pharmacology; D019684:Magnoliopsida; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D061686:Premature Ejaculation / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
chemical_list: D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D010936:Plant Extracts; D006220:Haloperidol; D004298:Dopamine