title: Genetic single-nucleotide polymorphisms of inflammation-related factors associated with risk of lung cancer.
abstract: This study was to investigate the association of inflammation-related factors with the risk of lung cancer. All subjects were unrelated ethnic Han Chinese in Liaoning province. Our study conducted a hospital-based case-control study, the case group consisted of 193 histologically diagnosed lung cancer patients, and 211 controls were selected from cancer-free patients at the same. 5 single-nucleotide polymorphisms (TGFβ1 +869T/C, IL6 -634C/G, TGFβ1 -509C/T, IL1β -511C/T, and IL1α -899C/T) in inflammatory genes (IL1, IL6, TGF) were analyzed by Taqman real-time PCR method. All statistical analyses were performed with statistical product and service solutions v13.0. The genotype distribution frequency of IL6 -634C/G exists significant difference between case and control group. Individuals carrying -634GG and CG genotype had a higher risk of lung cancer. The risk allele was G in IL6 -634C/G.
authors.affiliation: Department of Radiation Oncology, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, 110001 Shenyang, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Bai
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.forename: Hetong
authors.initials: H
authors.lastname: Wang
authors.forename: Hongxin
authors.initials: H
authors.lastname: Su
authors.forename: Junhua
authors.initials: J
authors.lastname: Zhao
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D007375:Interleukin-1 / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D008175:Lung Neoplasms / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D015291:Transforming Growth Factors / Q000235:genetics
chemical_list: C508600:IL6 protein, human; D007375:Interleukin-1; D015850:Interleukin-6; D015291:Transforming Growth Factors