title: Nanoparticle-based immunoassays in the biomedical field.
abstract: Recent research has looked to develop innovative, powerful and novel biofunctionalized nanoparticles, controlling and tailoring their properties in a very predictable manner to meet the needs of clinic immunoassays in the biomedical field. This minireview briefly summarizes recent advances covering the last 3 years, exploiting nanoparticle-based electrochemical, optical, mass-sensitive, colorimetric and immunodipstick assays. The enormous signal enhancement associated with the use of nanoparticles and formation of nanoparticle-antibody-antigen assemblies provide the basis for sensitive detection of disease-related proteins or biomarkers. Rather than being exhaustive, this minireview focuses on selected examples to illustrate novel concepts and promising applications. Finally, a small amount of speculation of possible future developments in nanoparticle-based immunoassays is provided.
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Department of Chemistry, Fuzhou University, 350108 Fuzhou, PR China. dianping.tang@fzu.edu.cn
authors.forename: Dianping
authors.initials: D
authors.lastname: Tang
authors.forename: Yuling
authors.initials: Y
authors.lastname: Cui
authors.forename: Guonan
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods* / Q000639:trends; D003124:Colorimetry / Q000379:methods / Q000639:trends; D055664:Electrochemical Techniques / Q000379:methods / Q000639:trends; D006801:Humans; D007118:Immunoassay / Q000379:methods* / Q000639:trends; D053758:Nanoparticles / Q000737:chemistry*