title: Ocular physiology and comfort in neophyte subjects fitted with daily disposable silicone hydrogel contact lenses.
abstract: OBJECTIVE
  To evaluate the performance of a silicone hydrogel daily disposable lens in neophyte subjects over 12 months.
  
  
  METHODS
  Seventy four subjects with no previous contact lens experience were randomised to wear narafilcon A (1 DAY ACUVUE(®) TruEye™) lenses (LW group) or to wear no contact lenses (NLW group) for 12 months. Biomicroscopy (performed by a masked investigator), visual acuity and subjective response scores were recorded at an initial visit and six follow-up visits, in addition to lens fit and surface evaluation for the LW group. Comfort was recorded with SMS messaging.
  
  
  RESULTS
  Fifteen of the LW group discontinued before the end of the study, compared with six of the NLW group. Measured visual acuity was about half a line better for the NLW group as these subjects were provided with their full sphero-cylindrical over-refraction, compared to the LW group in their best spherical corrected contact lenses; subjective scores for vision were similar for the two groups. Bulbar conjunctival hyperaemia, limbal hyperaemia, corneal staining, conjunctival staining and papillary conjunctivitis were clinically equivalent for the two groups whereas conjunctival staining was higher in the LW group. Comfort scores assessed by SMS were equivalent for the LW and NLW groups; there was a measurable improvement in comfort during the first month of wear for the LW group.
  
  
  CONCLUSIONS
  This work has demonstrated that modern soft lenses (narafilcon A daily disposable silicone hydrogel lenses) offer an excellent, comfortable form of vision correction, and are able to exhibit minimal alterations to ocular physiology.
authors.affiliation: Eurolens Research, The University of Manchester, Manchester, United Kingdom. philip.morgan@manchester.ac.uk
authors.forename: Philip B
authors.initials: PB
authors.lastname: Morgan
authors.forename: Paul
authors.initials: P
authors.lastname: Chamberlain
authors.forename: Kurt
authors.initials: K
authors.lastname: Moody
authors.forename: Carole
authors.initials: C
authors.lastname: Maldonado-Codina
mesh_terms: D000328:Adult; D003263:Contact Lenses, Hydrophilic; D004209:Disposable Equipment; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D020100:Hydrogels; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011474:Prosthesis Design; D012030:Refractive Errors / Q000175:diagnosis / Q000503:physiopathology* / Q000534:rehabilitation*; D012828:Silicones; D016896:Treatment Outcome; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D020100:Hydrogels; D012828:Silicones