title: MicroRNA-21 gene and cancer.
abstract: MicroRNAs (miRNAs) are a class of 18-27-nucleotides single-stranded RNA molecules that regulate gene expression at the post-transcriptional level. It has been demonstrated that miRNAs regulate a variety of physiological functions, including development, cell differentiation, proliferation, and apoptosis. There are growing evidence showed that miRNAs can affect the genesis and development of tumor and play a kind of tumor suppressor or oncogenic function by regulating its targetted gene-related signal pathway. miRNA-21 is one of the early discovered miRNAs in human cells, and the expression of miRNA-21 is significantly upregulated in different kinds of solid tumors. Its abnormal expression levels are closely associated with pathogenesis of cancers. This review summarizes the recent study on the field of miRNA-21 and its association with cancer.
authors.affiliation: Animal Science and Technology College, He Nan University of Science and Technology, Luoyang City 471003, Henan Province, People's Republic of China. huangyong1979111@163.com
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.forename: You Bing
authors.initials: YB
authors.lastname: Yang
authors.forename: Xiao Hui
authors.initials: XH
authors.lastname: Zhang
authors.forename: Xue Li
authors.initials: XL
authors.lastname: Yu
authors.forename: Zhan Bin
authors.initials: ZB
authors.lastname: Wang
authors.forename: Xiang Chao
authors.initials: XC
authors.lastname: Cheng
mesh_terms: D000818:Animals; D006801:Humans; D035683:MicroRNAs; D009369:Neoplasms / Q000235:genetics*
chemical_list: C524940:MIRN21 microRNA, human; D035683:MicroRNAs