title: Repigmentation of poliosis after epithelial grafting for vitiligo.
abstract: BACKGROUND
  Vitiligo is a disease of color loss from skin and possibly also from hair. The presence of white hair follicles is known to be a bad prognostic sign.
  
  
  OBJECTIVE
  To evaluate the possibility of repigmentation of white hair follicles after epithelial grafting.
  
  
  METHODS
  Patients with recalcitrant vitiligo with loss of hair pigment were treated using Chinese cupping blisters or ultrathin Thiersch grafting after de-epithelialization of vitiliginous patches by dermabrasion. Phototherapy was used afterward to enhance success.
  
  
  RESULTS
  Repigmentation of the skin surface was obtained with as little as 1 to 2 months of phototherapy, as expected, and further follow-up of cases revealed the re-coloring of hair follicles after 4 to 11 months.
  
  
  CONCLUSIONS
  Re-coloring of poliosis with vitiligo is possible but was unexpected because of the difference in mechanism and signaling required between hair bulb melanization and the surface skin. One likely mechanism to explain this change is that melanocyte stem cells are stimulated and migrate to supply hair bulbs with new mature melanocytes. Epithelial grafting of vitiligo with poliosis in hairy areas should be a treatment of choice when white hair tufts cause cosmetic disfigurement.
authors.affiliation: Department of Dermatology and Venereology, Faculty of Medicine, Minia University, Minia, Egypt. sherifu@rocketmail.com
authors.forename: Sherif S
authors.initials: SS
authors.lastname: Awad
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003869:Dermabrasion; D004848:Epithelium / Q000637:transplantation*; D005260:Female; D006200:Hair Color; D006201:Hair Diseases / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008297:Male; D010789:Phototherapy; D012880:Skin Pigmentation; D014820:Vitiligo / Q000150:complications / Q000601:surgery*