title: Polydopamine-coated magnetic nanoparticles for enrichment and direct detection of small molecule pollutants coupled with MALDI-TOF-MS.
abstract: Polydopamine-coated Fe(3)O(4) nanoparticles (Fe(3)O(4)@PDA NPs) were synthesized and applied as matrix for the detection of pollutants by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). The synthesis of Fe(3)O(4)@PDA NPs was accomplished in 30 min by in situ polymerization of dopamine without any toxic reagent. Using Fe(3)O(4)@PDA NPs as matrix of MALDI-TOF, eleven small molecule pollutants (molecular weight from 251.6 to 499.3), including Benzo(a)pyrene (BaP), three perfluorinated compounds (PFCs), and seven antibiotics, were successfully detected in either positive or negative reflection mode without background interference. Furthermore, the Fe(3)O(4)@PDA NPs can also enrich trace amounts of hydrophobic target, such as BaP, from solution to nanoparticles surface. Then the Fe(3)O(4)@PDA-BaP can be isolated through magnetic sedimentation step and directly spotted on the stainless steel plate for MALDI measurement. With Fe(3)O(4)@PDA NPs as adsorbent and matrix, we also realized the analysis of BaP in tap water and lake water samples. Thus, a magnetic solid-phase extraction (MSPE)-MALDI-TOF-MS method was established for the measurement of BaP.
authors.affiliation: The State Key Laboratory of Environmental Chemistry and Ecotoxicology of the Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
authors.forename: Yu-rong
authors.initials: YR
authors.lastname: Ma
authors.forename: Xiao-le
authors.initials: XL
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Zeng
authors.forename: Dong
authors.initials: D
authors.lastname: Cao
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhou
authors.forename: Wen-hui
authors.initials: WH
authors.lastname: Li
authors.forename: Hongyun
authors.initials: H
authors.lastname: Niu
authors.forename: Ya-qi
authors.initials: YQ
authors.lastname: Cai
mesh_terms: D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D005618:Fresh Water / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D060106:Lakes / Q000737:chemistry; D008280:Magnetics; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000295:instrumentation* / Q000379:methods; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D007211:Indoles; D011108:Polymers; D014874:Water Pollutants, Chemical; C568283:polydopamine