title: Common causes of anaphylaxis in children: the first report of anaphylaxis registry in iran.
abstract: BACKGROUND
  : Anaphylaxis is an acute, systemic, and potentially fatal allergic reaction. Many things can cause anaphylaxis potentially but some agents are more common like some foods (milk, egg, soy, wheat, peanut, tree nut, shellfish, and fish), insect stings, medications, latex, and food-dependent exercise-induced anaphylaxis. The goal of this study is to show the common causes of anaphylaxis among the children with anaphylaxis history who were referred to the Immunology, Asthma and Allergy Research Institute (IAARI) during a 4-year period (2005-2009).
  
  
  METHODS
  : During those 4 years, we registered all children (<14 years old) with a history of anaphylactic reaction. To prove the cause of anaphylaxis, we performed skin prick tests with suspected agents according to their history and measured specific IgE against them by the ImmunoCAP test. Recognition of common allergens was based on having a positive history for 1 allergen and positive skin prick test or specific IgE for that at the same time, or having positive results from both tests when the allergen was unclear. Idiopathic anaphylaxis was a reaction when any known allergen and positive tests were not obtained.
  
  
  RESULTS
  : One hundred ninety-three nonfatal anaphylactic attacks among 63 children were recognized. In total, the most current cause of anaphylaxis in children was food (89.7%). Milk (49.3%) and wheat (26.1%) were the most common. Other foods were egg (8.7%), nuts (2.8%), and spices (2.8%). Six children (8.7%) were sensitive to multiple food allergens like milk, egg, and wheat. Five (7.1%) of 63 patients had anaphylactic attack because of stinging. Wasp was the trigger in 3 (4.3%) of them and honeybee was the cause in 1 (1.4%). The last one was because of unknown hymenoptera. There were 2 idiopathic cases of all 63 patients.
  
  
  CONCLUSIONS
  : Food allergens, especially milk and wheat, are the most common cause of anaphylaxis in children. Because anaphylaxis can be fatal, it is advisable to recognize its causes in different communities to prevent recurrent attacks.
authors.affiliation: Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
authors.forename: Saeideh
authors.initials: S
authors.lastname: Barzegar
authors.forename: Akramian
authors.initials: A
authors.lastname: Rosita
authors.forename: Zahra
authors.initials: Z
authors.lastname: Pourpak
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Bemanian
authors.forename: Raheleh
authors.initials: R
authors.lastname: Shokouhi
authors.forename: Mahboubeh
authors.initials: M
authors.lastname: Mansouri
authors.forename: Taher
authors.initials: T
authors.lastname: Cheraghi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Chavoshzadeh
authors.forename: Iraj
authors.initials: I
authors.lastname: Mohammadzadeh
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Fazlollahi
authors.forename: Bahram
authors.initials: B
authors.lastname: Mirsaeedghazi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Nabavi
authors.forename: Masoud
authors.initials: M
authors.lastname: Movahedi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Gharagozlo
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Farahmand
authors.forename: Mostafa
authors.initials: M
authors.lastname: Moin