title: Derivative (5;19)(p10;q10): a rare but recurrent whole-arm translocation in acute myeloid leukemia.
abstract: A previous study of cases of myelodysplastic syndrome harboring der(5;19)(p10;q10) found that they displayed common characteristics including predominance in elderly men, dysplasia involving three hematopoietic lineages and CD7 expression in blasts. However, the whole-arm translocation der(5;19)(p10;q10) has not been fully analyzed because of its rarity. In this study we used flow cytometry to evaluate the immunophenotype of two patients' bone marrow mononuclear cells. Both patients had involved der(5;19)(p10;q10) in their karyotype analyzed by standard G-banding technique. Both patients had the CD7+ and CD41+ phenotype, and the CD41 positivity suggested that the myeloid neoplasms involving der(5;19)(p10;q10) were of megakaryoblastic origin. The der(5;19)(p10;q10) abnormality is associated with unique characteristics of the immunophenotype. We address the clinical, immunophenotypic and morphological aspects of hematological malignancy involving der(5;19)(p10;q10), along with a review of the literature.
authors.affiliation: Department of Hematology, Seichokai Fuchu Hospital, Izumi, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Manabe
authors.forename: Teruhito
authors.initials: T
authors.lastname: Takakuwa
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nakano
authors.forename: Naonori
authors.initials: N
authors.lastname: Harada
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Okamoto
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Aoyama
authors.forename: Takeo
authors.initials: T
authors.lastname: Kumura
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Ohta
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Furukawa
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Matsuda
authors.forename: Atsuko
authors.initials: A
authors.lastname: Mugitani
mesh_terms: D000368:Aged; D002888:Chromosomes, Human, Pair 19; D002895:Chromosomes, Human, Pair 5; D020732:Cytogenetic Analysis; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
keywords: CD41; acute myeloid leukemia; der(5;19)(p10;q10); megakaryoblast; whole-arm translocation