title: Improving outcomes after cardiac arrest using NO inhalation.
abstract: Despite advances in cardiopulmonary resuscitation (CPR) methods including therapeutic hypothermia (TH), long-term neurological outcomes and survival after sudden cardiac arrest (CA) remains to be dismal. While nitric oxide (NO) prevents organ injury induced by ischemia and reperfusion (I/R), systemic vasodilation induced by intravenous NO-donor compounds typically precludes its use in post-CA patients in whom blood pressure is often low and unstable. Although developed as a selective pulmonary vasodilator, inhaled NO has systemic benefits in a variety of pre-clinical and clinical studies without causing potentially harmful systemic vasodilation. Breathing NO after CPR may prevent post-CA brain injury and improve long-term outcomes after CA and CPR.
authors.affiliation: Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. fichinose@partners.org
authors.forename: Fumito
authors.initials: F
authors.lastname: Ichinose
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D016887:Cardiopulmonary Resuscitation; D006323:Heart Arrest / Q000628:therapy*; D051379:Mice; D009569:Nitric Oxide / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D009569:Nitric Oxide