title: Small ruminant lentivirus genotype B and E interaction: evidences on the role of Roccaverano strain on reducing proviral load of the challenging CAEV strain.
abstract: Live attenuated vaccines provide the most consistent protective immunity in experimental models of lentivirus infections. In this study we tested the hypothesis that animals infected with a naturally attenuated small ruminant lentivirus field strain of genotype E may control a challenge infection with a virulent strain of the caprine arthritis encephalitis virus (CAEV-CO). Within genotype E, Roccaverano strain has been described as attenuated since decreased arthritic pathological indexes were recorded in Roccaverano-infected animals compared to animals of the same breed infected with genotype B strains. Moreover, under natural conditions, animals double-infected with genotypes B and E appear less prone to develop SRLV-related disease, leading to a putative protective role of Roccaverano strain. Here we present evidence that goats experimentally infected with the avirulent genotype E SRLV-Roccaverano strain control the proviral load of a pathogenic challenge virus (CAEV-CO strain) more efficiently than naïve animals and appear to limit the spread of histological lesions to the contralateral joints.
authors.affiliation: Department of Veterinary Science, University of Torino, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Bertolotti
authors.forename: Ramsés
authors.initials: R
authors.lastname: Reina
authors.forename: Maurizio
authors.initials: M
authors.lastname: Mazzei
authors.forename: Silvia
authors.initials: S
authors.lastname: Preziuso
authors.forename: Michele
authors.initials: M
authors.lastname: Camero
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Carrozza
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cavalli
authors.forename: Magda
authors.initials: M
authors.lastname: Juganaru
authors.forename: Margherita
authors.initials: M
authors.lastname: Profiti
authors.forename: Daniele
authors.initials: D
authors.lastname: De Meneghi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Perona
authors.forename: Giacomo
authors.initials: G
authors.lastname: Renzoni
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Tursi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bertoni
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosati
mesh_terms: D000818:Animals; D016088:Arthritis-Encephalitis Virus, Caprine / Q000235:genetics / Q000502:physiology*; D002460:Cell Line; D049109:Cell Proliferation; D005838:Genotype; D015511:Goat Diseases / Q000276:immunology / Q000473:pathology / Q000517:prevention & control* / Q000821:virology*; D006041:Goats; D016086:Lentivirus / Q000235:genetics / Q000276:immunology*; D016180:Lentivirus Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D011533:Proviruses / Q000502:physiology; D012418:Ruminants; D013601:T-Lymphocytes / Q000166:cytology; D019562:Viral Load