title: A phosphatidylcholine hyaluronic acid chitin-nanofibrils complex for a fast skin remodeling and a rejuvenating look.
abstract: BACKGROUND
  The reduction of mortality worldwide has led older individuals to seek intervention modalities to improve their appearance and reverse signs of aging.
  
  
  OBJECTIVE
  We formulated a medical device as innovative block-polymer nanoparticles based on phosphatidylcholine, hyaluronan, and chitin nanofibrils entrapping amino acids, vitamins, and melatonin.
  
  
  METHODS
  Viability and collagen synthesis were controlled on fibroblasts ex vivo culture while adenosine triphosphate production was evaluated on keratinocytes culture. Subjective and objective evaluations were performed in vivo on selected volunteer patients.
  
  
  RESULTS
  In accordance with our previous studies, both the in vitro and in vivo obtained results demonstrate the efficacy of the injected block-polymer nanoparticles in reducing skin wrinkling and ameliorating the signs of aging.
authors.affiliation: Department of Applied Cosmetic Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Morganti
authors.forename: Paolo
authors.initials: P
authors.lastname: Palombo
authors.forename: Marco
authors.initials: M
authors.lastname: Palombo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Fabrizi
authors.forename: Antonio
authors.initials: A
authors.lastname: Cardillo
authors.forename: Fabiano
authors.initials: F
authors.lastname: Svolacchia
authors.forename: Luis
authors.initials: L
authors.lastname: Guevara
authors.forename: Paolo
authors.initials: P
authors.lastname: Mezzana
keywords: antiaging agent; biostimulation; photoaging; scar correction; signaling molecules; stretch marks