title: [The role of whole brain radiation therapy for brain metastases].
abstract: Brain metastases are the leading cause of intracranial malignancy and a major cause of mortality and morbidity. From 20 to 40% of cancer patients develop brain metastases. The irradiation of the whole brain remains the most commonly undertaken treatment, but should be discussed in relation to other therapeutic alternatives such as stereotactic radiotherapy or the use of new chemotherapy drugs. Its use according to pathology should be discussed. It can lead to a long-term neurocognitive toxicity that should be evaluated more precisely. This literature review aims to highlight the role of whole-brain radiotherapy used alone or in combination with other treatments.
authors.affiliation: Centre de lutte contre le cancer Paul-Strauss, département universitaire de radiothérapie, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Antoni
authors.forename: Georges
authors.initials: G
authors.lastname: Noël
authors.forename: Françoise
authors.initials: F
authors.lastname: Mornex
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary* / Q000601:surgery; D003131:Combined Modality Therapy / Q000379:methods; D016371:Cranial Irradiation / Q000379:methods*; D019583:Dose Fractionation, Radiation; D006801:Humans; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D016634:Radiosurgery / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents
keywords: brain metastasis; whole brain radiation therapy