title: Multiple disseminated glomuvenous malformations: do we know enough?
abstract: Multiple glomuvenous malformations (GVMs), also known as glomangiomas, are uncommon entities with histological features of both glomus cells proliferation and venous malformation. A 14-year-old boy was admitted to our clinic with multiple dermal blue nodules, disseminated in different segments of the body. The patient's family history was positive for similar lesions; his mother and maternal grandmother had some asymptomatic blue nodules on their body. Histological examination showed a tumor composed of multiple caveronous vessels surrounded by glomus cells, positive for alpha smooth muscle actin, HHF35 (pan-actin), and h-caldesmon. This is a case of multiple GVMs, a rare disease caused by mutations in glomulin gene, with an autosomal dominant pattern of inheritance. The clinical and histopathological features are briefly discussed.
authors.affiliation: Department of Dermatology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Solovan
authors.forename: Elena
authors.initials: E
authors.lastname: Chiticariu
authors.forename: Doina
authors.initials: D
authors.lastname: Beinsan
authors.forename: Sabina
authors.initials: S
authors.lastname: Zurac
authors.forename: Flavia
authors.initials: F
authors.lastname: Baderca
mesh_terms: D000293:Adolescent; D005918:Glomus Tumor / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology