title: Designing a peptide-based vaccine against Porphyromonas gingivalis.
abstract: Using proteome databases and exploiting the concept that a rare sequence is a potential epitope, epitopic sequences derived from Porphyromonas gingivalis fimA type I protein were examined for pentapeptide sequence similarity score to the human proteome. We obtained data showing that most of the linear bacterial determinants are (or are formed by) peptide fragment(s) absent (or rarely found) in the human proteins. These results seem to confirm the hypothesis that low-sequence similarity may contribute to shape the epitope repertoire and provides a potential tool for designing new immunotherapeutic approaches to apply in Porphyromonas gingivalis infected periodontitis.
authors.affiliation: Department of Odontostomatological, Orthodontics and Surgical Disciplines, Second University of Naples SUN, Naples, Italy.
authors.forename: Alberta
authors.initials: A
authors.lastname: Lucchese
authors.forename: Agostino
authors.initials: A
authors.lastname: Guida
authors.forename: Giovanni
authors.initials: G
authors.lastname: Capone
authors.forename: Massimo
authors.initials: M
authors.lastname: Petruzzi
authors.forename: Dorina
authors.initials: D
authors.lastname: Lauritano
authors.forename: Rosario
authors.initials: R
authors.lastname: Serpico
mesh_terms: D000595:Amino Acid Sequence; D001428:Bacterial Vaccines / Q000737:chemistry* / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D036781:Fimbriae Proteins / Q000737:chemistry* / Q000276:immunology*; D006801:Humans; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology; D016966:Porphyromonas gingivalis / Q000276:immunology*; D020543:Proteome / Q000276:immunology; D022223:Vaccines, Subunit / Q000737:chemistry / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D000939:Epitopes; D010446:Peptide Fragments; D020543:Proteome; D022223:Vaccines, Subunit; C063055:fimbrillin; D036781:Fimbriae Proteins