title: A comparative evaluation of the efficacy of two novel desensitising dentifrices.
abstract: A comparison of the desensitising efficacy of two commercially available dentifrices with different modes of action was conducted in a randomised, examiner-blind, two-arm, parallel group, 8-week, longitudinal clinical study. Dentifrice A, (Sensodyne Multi Action Iso-Active), contained 50000 ppm KNO(3) and 1450 ppm fluoride as NaF. Dentifrice B, Colgate Sensitive Pro-Relief, contained a combination of 80000 ppm arginine, bicarbonate, calcium carbonate, and 1450 ppm fluorine as NaMFP. Subjects (N = 110), stratified into two groups (N = 55), brushed twice-daily for 60 s, over an 8-week period. Sensitivity status, compliance, and safety were determined at 1, 2, 4, and 8 weeks. A fixed-effects ANCOVA statistical model was applied to the Intent-To-Treat population using a two-sided 5% significance level. After 8 weeks, the treatment groups using Dentifrice A and Dentifrice B exhibited mean reductions from baseline of 49% and 45% in air sensitivity visual analogue scale (VAS) score, 61% (both) in examiner-based Schiff Sensitivity score, and clinically significant reductions in tactile pain threshold; all reductions were statistically significant (P < 0.0001). Both treatment groups also exhibited significant reductions across all sensitivity measures at 1, 2, and 4 weeks (P ≤ 0.0059, Dentifrice A; P ≤ 0.0137, Dentifrice B).
authors.affiliation: GlaxoSmithKline Consumer Healthcare, Surrey Weybridge, KT13 0DE, UK.
authors.forename: Ashley P
authors.initials: AP
authors.lastname: Barlow
authors.forename: Jane
authors.initials: J
authors.lastname: He
authors.forename: Cindy
authors.initials: C
authors.lastname: Tian
authors.forename: Peter
authors.initials: P
authors.lastname: Jeffery
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Mason
authors.forename: Bao-Jun
authors.initials: BJ
authors.lastname: Tai
authors.forename: Han
authors.initials: H
authors.lastname: Jiang
authors.forename: Gareth D
authors.initials: GD
authors.lastname: Rees
authors.forename: Min Quan
authors.initials: MQ
authors.lastname: Du