title: Cord blood transplantation in aplastic anemia.
abstract: For patients with inherited BM failure (BMF) or those with acquired BMF who fail immunosuppressive therapy and who lack a suitable alternative donor, the prognosis remains poor. Umbilical cord blood transplantation has extended the availability of hematopoietic stem cell transplantation in the absence of a suitable donor. A recent EBMT study confirmed the feasibility of this treatment and highlighted the fundamental role of the TNC dose (>3.9 × 10(7)/kg TNC/kg) on both engraftment and OS using cord blood as stem cell source in severe aplastic anemia. However, this procedure is still experimental and should be evaluated only through prospective clinical trials.
authors.affiliation: Bone Marrow Transplant Unit, Hôpital Saint Louis-APHP, Université Paris VII, Paris, France. regis.peffaultdelatour@sls.aphp.fr
authors.forename: R
authors.initials: R
authors.lastname: Peffault de Latour
authors.forename: V
authors.initials: V
authors.lastname: Rocha
authors.forename: G
authors.initials: G
authors.lastname: Socié
mesh_terms: D000741:Anemia, Aplastic / Q000601:surgery*; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D019172:Transplantation Conditioning / Q000379:methods