title: Asymmetric organocatalytic allylic alkylation of Reissert compounds: a facile access to chiral 1,1-disubstituted 1,2-dihydroisoquinolines.
abstract: The first asymmetric organocatalytic allylic alkylation of 1,2-dihydro-Reissert compounds and Morita-Baylis-Hillman (MBH) carbonates has been developed, which provided a novel protocol to construct enantioenriched functionalized 1,2-dihydroisoquinolines bearing vicinal quaternary and tertiary chiral centers at C-1 position (up to 94% ee, dr > 20 : 1).
authors.affiliation: Department of Organic Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
authors.forename: Tian-You
authors.initials: TY
authors.lastname: Qin
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Liao
authors.forename: Yan-Jing
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Sean Xiao-An
authors.initials: SX
authors.lastname: Zhang
mesh_terms: D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D007546:Isoquinolines / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D002254:Carbonates; D007546:Isoquinolines