title: [(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity.
abstract: The antischistosomal effect of two [(η(6)-praziquantel)Cr(CO)(3)] derivatives was investigated. The compounds (see figure: Cr purple, N blue, O red) were prepared in a one-step procedure from commercially available praziquantel. Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and only a minor cytotoxic effect on selected mammalian cell lines.
authors.affiliation: Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
authors.forename: Malay
authors.initials: M
authors.lastname: Patra
authors.forename: Katrin
authors.initials: K
authors.lastname: Ingram
authors.forename: Vanessa
authors.initials: V
authors.lastname: Pierroz
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferrari
authors.forename: Bernhard
authors.initials: B
authors.lastname: Spingler
authors.forename: Robin B
authors.initials: RB
authors.lastname: Gasser
authors.forename: Jennifer
authors.initials: J
authors.lastname: Keiser
authors.forename: Gilles
authors.initials: G
authors.lastname: Gasser
mesh_terms: D000818:Animals; D002857:Chromium / Q000737:chemistry* / Q000494:pharmacology*; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D011223:Praziquantel / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000187:drug effects*; D012556:Schistosomicides / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use*; D013237:Stereoisomerism
chemical_list: C582971:(eta(6)-praziquantel)Cr(CO)3; D056831:Coordination Complexes; D012556:Schistosomicides; D002857:Chromium; D011223:Praziquantel