title: Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles.
abstract: OBJECTIVE
  To evaluate the ability of manganese perovskite nanoparticles (lanthanum-strontium manganite) to heat the tumor tissue in vivo under action of external alternating magnetic field.
  
  
  METHODS
  The magnetic fluid on the basis of nanoparticles of perovskite manganite was tested in the heating experiments using of alternating magnetic field of frequency 300 kHz and amplitude 7.7 kA/m. Guerin carcinoma was transplanted into the muscle of rat. Magnetic fluid was injected intramuscularly or intratumorally. Temperature was measured by copper-constantan thermocouple.
  
  
  RESULTS
  Temperature of magnetic fluid was increased by 56 °C for 10 min of alternating magnetic field action. Administration of magnetic fluid into the muscle followed by alternating magnetic field resulted in the elevation of muscle temperature by 8 °C after 30 min post injection. Temperature of the tumor injected with magnetic fluid and treated by alternating magnetic field was increased by 13.6 °C on the 30 min of combined influence.
  
  
  CONCLUSIONS
  In vivo study with rat tissue has demonstrated that magnetic fluid of manganite perovskite injected in the tumor increases the tumor temperature under an alternating magnetic field. Obtained results emphasize that magnetic fluid of manganite perovskite can be considered as effective inducer of tumor hyperthermia.
authors.affiliation: RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine.
authors.forename: L
authors.initials: L
authors.lastname: Bubnovskaya
authors.forename: A
authors.initials: A
authors.lastname: Belous
authors.forename: A
authors.initials: A
authors.lastname: Solopan
authors.forename: A
authors.initials: A
authors.lastname: Podoltsev
authors.forename: I
authors.initials: I
authors.lastname: Kondratenko
authors.forename: A
authors.initials: A
authors.lastname: Kovelskaya
authors.forename: T
authors.initials: T
authors.lastname: Sergienko
authors.forename: S
authors.initials: S
authors.lastname: Osinsky
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017610:Calcium Compounds / Q000494:pharmacology; D005260:Female; D006979:Hyperthermia, Induced / Q000379:methods*; D007811:Lanthanum / Q000494:pharmacology; D055909:Magnetic Field Therapy / Q000379:methods; D008345:Manganese / Q000494:pharmacology; D017895:Manganese Compounds / Q000494:pharmacology*; D053758:Nanoparticles; D009374:Neoplasms, Experimental / Q000628:therapy*; D010087:Oxides / Q000494:pharmacology; D051381:Rats; D013324:Strontium / Q000494:pharmacology; D014025:Titanium / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D017610:Calcium Compounds; D017895:Manganese Compounds; D010087:Oxides; C494384:manganite; C059910:perovskite; D008345:Manganese; D007811:Lanthanum; D014025:Titanium; D013324:Strontium