title: Focal magnetic resonance guided focused ultrasound for prostate cancer: Initial North American experience.
abstract: The treatment of low-risk prostate cancer is a common clinical dilemma between standard curative whole gland therapy (and its associated quality of life diminishing side effects) and active surveillance (and its low, but real, risk of progression). The goal of focal therapy in low-risk prostate cancer is to achieve the best balance between cancer control and maintenance of quality of life. Magnetic resonance-guided focused ultrasound (MRgFUS) surgery is a non-invasive thermal ablation method that integrates magnetic resonance imaging for target identification, treatment planning and closed-loop control of thermal deposition and focused ultrasound for thermal ablation of the tumour target. This novel transrectal system allows for tumour localization, targeting and monitoring of tumour target ablation in real time, while simultaneously preserving adjacent normal tissue thereby minimizing the side effects of standard curative surgical or radiation therapy. We report the first North American clinical experience of treatment of localized prostate cancer with focal MR-guided transrectal focused ultrasound (clinicaltrial.gov identifier NCT01226576).
authors.affiliation: Division of Urology, Department of Surgical Oncology, University Health Network, and Department of Surgery, University of Toronto, Toronto, ON;
authors.forename: Uri
authors.initials: U
authors.lastname: Lindner
authors.forename: Sangeet
authors.initials: S
authors.lastname: Ghai
authors.forename: Paula
authors.initials: P
authors.lastname: Spensieri
authors.forename: Eugen
authors.initials: E
authors.lastname: Hlasny
authors.forename: Theodorus H
authors.initials: TH
authors.lastname: Van Der Kwast
authors.forename: Stuart A
authors.initials: SA
authors.lastname: McCluskey
authors.forename: Masoom A
authors.initials: MA
authors.lastname: Haider
authors.forename: Walter
authors.initials: W
authors.lastname: Kucharczyk
authors.forename: John
authors.initials: J
authors.lastname: Trachtenberg