title: Prognostic impact of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with internal tandem duplication of FLT3.
abstract: The FLT3 gene with internal tandem duplication (ITD) is a poor prognostic factor in patients with acute myeloid leukemia (AML), and the efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) for AML patients with FLT3-ITD is controversial. We examined 122 AML patients; 34 patients had FLT3-ITD and 39 patients received allogeneic HSCT. The median overall survival (OS) of patients with wtFLT3/nonHSCT, wtFLT3/HSCT, FLT3-ITD/nonHSCT and FLT3-ITD/HSCT was 40.7 months, 53.4 months, 9.8 months and not reached, respectively (p=0.006). Compared to the wtFLT3/nonHSCT patients, the hazard ratio (95% CI) of OS for wtFLT3/HSCT, FLT3-ITD/nonHSCT and FLT3-ITD/HSCT was 1.39 (0.61-3.18), 3.57 (1.58-8.10) and 0.40 (0.11-1.59), respectively, after adjustment of age, sex, WBC, LDH, karyotype, NPM, and FAB classification. This result indicated that patients with FLT3-ITD/nonHSCT had a significantly worse outcome, but allogeneic HSCT improved the prognosis for patients with FLT3-ITD.
authors.affiliation: Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Po-Han
authors.initials: PH
authors.lastname: Lin
authors.forename: Ching-Chan
authors.initials: CC
authors.lastname: Lin
authors.forename: Hwai-I
authors.initials: HI
authors.lastname: Yang
authors.forename: Long-Yuan
authors.initials: LY
authors.lastname: Li
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Bai
authors.forename: Chang-Fang
authors.initials: CF
authors.lastname: Chiu
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: Liao
authors.forename: Chen-Yuan
authors.initials: CY
authors.lastname: Lin
authors.forename: Ching-Yun
authors.initials: CY
authors.lastname: Hsieh
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Lin
authors.forename: Cheng-Mao
authors.initials: CM
authors.lastname: Ho
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Yang
authors.forename: Ching-Tien
authors.initials: CT
authors.lastname: Peng
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
authors.forename: Su-Peng
authors.initials: SP
authors.lastname: Yeh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D020440:Gene Duplication / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D020080:Tandem Repeat Sequences; D014184:Transplantation, Homologous; D055815:Young Adult; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3