title: ANRIL: molecular mechanisms and implications in human health.
abstract: ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions. ANRIL has been shown to regulate its neighbor tumor suppressors CDKN2A/B by epigenetic mechanisms and thereby regulate cell proliferation and senescence. However, the clear role of ANRIL in the pathogenesis of these conditions is yet to be understood. Here, we review the recent findings on ANRIL molecular characterization and function, with a particular focus on its implications in human disease.
authors.affiliation: Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 B6, Yamadaoka, Suita, Osaka 565-0871, Japan. ohishi@geriat.med.osaka-u.ac.jp.
authors.forename: Ada
authors.initials: A
authors.lastname: Congrains
authors.forename: Kei
authors.initials: K
authors.lastname: Kamide
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ohishi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Rakugi
mesh_terms: D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D011683:Purine-Nucleoside Phosphorylase / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: C561518:CDKN2B antisense RNA, human; C493966:CDKN2B protein, human; D050762:Cyclin-Dependent Kinase Inhibitor p15; D019941:Cyclin-Dependent Kinase Inhibitor p16; D062085:RNA, Long Noncoding; D011683:Purine-Nucleoside Phosphorylase; C021784:5'-methylthioadenosine phosphorylase