title: Differentiation of stem cells into insulin-producing cells: current status and challenges.
abstract: Diabetes mellitus is one of the most serious public health challenges of the twenty-first century. Allogenic islet transplantation is an efficient therapy for type 1 diabetes. However, immune rejection, side effects of immunosuppressive treatment as well as lack of sufficient donor organs limits its potential. In recent years, several promising approaches for generation of new pancreatic β cells have been developed. This review provides an overview of current status of pancreatic and extra-pancreatic stem cells differentiation into insulin-producing cells and the possible application of these cells for diabetes treatment. The PubMed database was searched for English language articles published between 2001 and 2012, using the keyword combinations: diabetes mellitus, differentiation, insulin-producing cells, stem cells.
authors.affiliation: Department of Tissue Engineering, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Karlowicza 24, 85-092 Bydgoszcz, Poland. marta.pokrywczynska@interia.pl
authors.forename: Marta
authors.initials: M
authors.lastname: Pokrywczynska
authors.forename: Sandra
authors.initials: S
authors.lastname: Krzyzanowska
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Jundzill
authors.forename: Jan
authors.initials: J
authors.lastname: Adamowicz
authors.forename: Tomasz
authors.initials: T
authors.lastname: Drewa
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000166:cytology*; D016381:Islets of Langerhans Transplantation; D013234:Stem Cells / Q000166:cytology*
chemical_list: D007328:Insulin