title: Prerequisites for the pharmaceutical industry to develop and commercialise helminths and helminth-derived product therapy.
abstract: During the past 10 years, immunologists, epidemiologists and parasitologists have made many new exciting discoveries in the field of helminth-mediated immune regulation. In addition, many animal experiments have shown that certain helminths or products derived from helminths can protect mice from developing allergic or autoimmune disease. Some clinical trials utilising Trichuris suis or Necator americanus for the treatment of allergic disorders and inflammatory bowel disease have been conducted. The outcomes of these trials suggest that they may be used to treat these disorders. However, to date no helminth therapy is routinely being applied to patients and no helminth-derived product therapy has been developed. In order to bring new drugs to the market and shoulder the enormous costs involved in developing such therapies, pharmaceutical companies need to be involved. However, currently the resources from the pharmaceutical industry devoted to this concept are relatively small and there are good reasons why the industry may have been reluctant to invest in developing these types of therapies. In this review article, the hurdles that must be overcome before the pharmaceutical industry might invest in these novel therapies are outlined.
authors.affiliation: Department of Respiratory Diseases Research, Boehringer Ingelheim, Biberach, Germany.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Tilp
authors.forename: Vishal
authors.initials: V
authors.lastname: Kapur
authors.forename: Will
authors.initials: W
authors.lastname: Loging
authors.forename: Klaus J
authors.initials: KJ
authors.lastname: Erb
mesh_terms: D000818:Animals; D004345:Drug Industry / Q000191:economics*; D004358:Drug Therapy / Q000191:economics*; D006376:Helminths / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D051379:Mice; D061147:Therapy with Helminths / Q000191:economics*