title: [Morphological characteristics of stromal fibroblasts and limphocites in colon and breast cancer].
abstract: Stromal substance, lymphocytes (populations and subpopulations) and different mature fibroblasts were studied in the colon and breast cancers by the histology, electron microscopy, and immunocytochemistry and electron radioautographic methods.   In cancer stroma marked decrease the total number of T and B cells, in addition to a disturbance of the relations between populations and subpopulations, witch leads to the imbalance of the immune response to tumor growth.  In the colon and breast cancer  the disturbance of the specific function of fibroblasts and the violation of their cytodifferentiation occur. The above is confirmed by the electronradioautography study of DNA, RNA and aminoacid mixture synthesis. Perversion of the specific function appears by the decrease the number of sulfated glycosaminoglycans and increase the number of nonsulfated fraction. We believe that the change of the cancer stromal chemical substance composition is also one of the basic precondition of local immune response damage, which in turn promotes cancer cells invasion.
authors.affiliation: Tbilisi I. Javakhishvili State University, A.N. Natishvili, Institute of Morphology, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Gvamichava
authors.forename: I
authors.initials: I
authors.lastname: Gachechiladze
authors.forename: T
authors.initials: T
authors.lastname: Machavariani
authors.forename: L
authors.initials: L
authors.lastname: Gogiashvili
mesh_terms: D001345:Autoradiography; D001402:B-Lymphocytes / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D017154:Stromal Cells / Q000473:pathology*; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology