title: Copeptin and cardiovascular disease: a review of a novel neurohormone.
abstract: Neurohormones (NHs) in the cascade of the arginine vasopressin (AVP) system have drawn particular attention in the recent years. Copeptin, the C-terminal portion of provasopressin, is a novel NH of the AVP system, and is known to be co-released with AVP from hypothalamus (neurohypophysis). As a surrogate marker of the AVP system, copeptin has gradually replaced AVP in several clinical studies largely due to its structural and methodological advantages. Copeptin has been regarded as a marker of non-specific stress response, and has also been suggested to have clinical implications in a variety of non-cardiovascular (pneumonia, sepsis, etc.) and cardiovascular conditions (heart failure and acute coronary syndromes (ACSs, etc.)). However, current data on relation of copeptin with other cardiovascular conditions ( arrhythmias, etc.) are still insufficient. The present review primarily focuses on general features of copeptin, its general clinical implications, and specifically aims to cover its potential clinical value in a variety of cardiovascular conditions.
authors.affiliation: Trakya University, Cardiology Department, Edirne, Turkey. kyalta@gmail.com
authors.forename: Kenan
authors.initials: K
authors.lastname: Yalta
authors.forename: Tulin
authors.initials: T
authors.lastname: Yalta
authors.forename: Nasir
authors.initials: N
authors.lastname: Sivri
authors.forename: Ertan
authors.initials: E
authors.lastname: Yetkin
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis*; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D018377:Neurotransmitter Agents / Q000097:blood*
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; D018377:Neurotransmitter Agents; C048197:copeptins
keywords: Arginine vasopressin; Cardiovascular disease; Clinical implication; Copeptin