title: The hematopoietic stem cell niche--home for friend and foe?
abstract: The hematopoietic stem cell (HSC) niche is involved in the maintainance and regulation of quiescence, self-renewal and differentiation of hematopoietic stem cells and the fate of their progeny in mammals dealing with the daily stresses to the hematopoietic system. From the discovery that perturbations of the HSC niche can lead to hematopoietic disorders, we have now arrived at the prospect that the HSC niche may play a role in hematological malignancies and that this HSC niche may be a target for therapy. This review attempts to capture the discoveries of the last few years regarding the normal and malignant hematopoietic stem cell niche and possible ways to target this niche.
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. dkrause1@partners.org
authors.forename: Daniela S
authors.initials: DS
authors.lastname: Krause
authors.forename: David T
authors.initials: DT
authors.lastname: Scadden
authors.forename: Frederic I
authors.initials: FI
authors.lastname: Preffer
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000502:physiology; D001854:Bone Marrow Cells / Q000502:physiology; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D005109:Extracellular Matrix / Q000502:physiology; D019337:Hematologic Neoplasms; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000502:physiology; D019089:Stem Cell Factor / Q000378:metabolism; D055153:Stem Cell Niche
chemical_list: D016207:Cytokines; D019089:Stem Cell Factor