title: Chlorella sorokiniana-Induced Activation and Maturation of Human Monocyte-Derived Dendritic Cells through NF-κB and PI3K/MAPK Pathways.
abstract: Chlorella sorokiniana (CS) is a unicellular green alga. The extracts of Chlorella have been used as treatments for relieving hypertension and modulating immune response. The detailed mechanisms are not clear yet. In this study, we sought to study the molecular mechanisms for the polysaccharide fraction of CS-induced immune response. We pulsed dendritic cells (DCs) with CS and found that CS could maturate DCs. CS-maturated DC could activate naïve T cells and stimulate T-cell proliferation and IFN-γ secretion. Furthermore, CS activated PI3K and MAPKs signaling pathways in DCs by interacting with TLR4 receptor. These CS-activated signaling pathways could further activate NF-κB and induce IL-12 production in DCs. This study provides molecular mechanisms for CS-induced DCs activation and immune response.
authors.affiliation: Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 31040, Taiwan.
authors.forename: Nien-Tzu
authors.initials: NT
authors.lastname: Chou
authors.forename: Chieh-Fang
authors.initials: CF
authors.lastname: Cheng
authors.forename: Hsin-Chieh
authors.initials: HC
authors.lastname: Wu
authors.forename: Chin-Pen
authors.initials: CP
authors.lastname: Lai
authors.forename: Li-Tsen
authors.initials: LT
authors.lastname: Lin
authors.forename: I-Horng
authors.initials: IH
authors.lastname: Pan
authors.forename: Ching-Huai
authors.initials: CH
authors.lastname: Ko