title: TGM2 and implications for human disease: role of alternative splicing.
abstract: Alternative splicing is an important mechanism for modulating gene function that accounts for a considerable proportion of proteomic complexity in higher eukaryotes. Alternative splicing is often tightly regulated in a cell-type- or developmental-stage- specific manner and can cause a single gene to have multiple functions. Human Tissue transglutaminase (TGM2) is a multifunctional enzyme with transglutaminase crosslinking (TGase), G protein signaling and kinase activities that are postulated to play a role in many disease states. TGM2 mRNA is regulated by alternative splicing, producing C-terminal truncated forms of TGM2 that are predicted to have distinct biochemical properties and biological functions. In this review, we will discuss how alternatively spliced forms of TGM2 could modulate its roles in cancer, neurodegeneration, inflammation and wound healing.
authors.affiliation: Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA.
authors.forename: Thung-S
authors.initials: TS
authors.lastname: Lai
authors.forename: Charles S
authors.initials: CS
authors.lastname: Greenberg
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D015551:Autoimmunity / Q000502:physiology; D002118:Calcium / Q000494:pharmacology; D002448:Cell Adhesion / Q000502:physiology; D058750:Epithelial-Mesenchymal Transition; D019204:GTP-Binding Proteins; D006160:Guanosine Triphosphate / Q000494:pharmacology; D006801:Humans; D008958:Models, Molecular; D019636:Neurodegenerative Diseases / Q000503:physiopathology; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology
chemical_list: C000717608:TGM2 protein, human; D006160:Guanosine Triphosphate; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins; D002118:Calcium