title: [Approaches to the improvement of treatment efficacy in patients with acute severe asaleptin intoxication complicated by acute respiratory insufficiency of mixed genesis].
abstract: We studied the development of metabolic disorders related to tissue hypoxia in 54 patients with acute severe asaleptin intoxication complicated by acute respiratory insfficiency of mixed genesis. We also estimated the role of a substrate antihypoxant cytoflavin in the correction of these disorders and clinical features of acute intoxication. Cyroflavin was shown to accelerate normalization of metabolic disorders which in turn improves clinical symptoms of severe forms of acute asaleptin intoxication.
authors.forename: V V
authors.initials: VV
authors.lastname: Shilov
authors.forename: A Yu
authors.initials: AY
authors.lastname: Andriaov
authors.forename: A T
authors.initials: AT
authors.lastname: Loladze
authors.forename: B V
authors.initials: BV
authors.lastname: Batotsyrenov
mesh_terms: D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000506:poisoning*; D003024:Clozapine / Q000506:poisoning*; D004338:Drug Combinations; D005260:Female; D005486:Flavin Mononucleotide / Q000494:pharmacology; D006801:Humans; D000860:Hypoxia / Q000473:pathology; D007290:Inosine Diphosphate / Q000494:pharmacology; D008297:Male; D008659:Metabolic Diseases / Q000188:drug therapy / Q000503:physiopathology; D008875:Middle Aged; D009536:Niacinamide / Q000494:pharmacology; D012131:Respiratory Insufficiency / Q000503:physiopathology*; D012720:Severity of Illness Index; D013386:Succinates / Q000494:pharmacology; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D004338:Drug Combinations; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D003024:Clozapine