title: Sarcoma of the ewing family in pregnancy: a case report of intrauterine fetal death after induction of chemotherapy.
abstract: Ewing's sarcoma is an ultra-orphan disease (2/1,000,000/year) which requires a multimodal therapy approach in high-volume centers. Treatment consists of pre-operative therapy followed by surgery and post-operative combination of chemo-radiotherapy. Experience with diagnosis and therapy of Ewing's sarcoma in pregnancy is very limited. We herein report the case of an atypical Ewing's sarcoma detected in the second trimester of gestation. Neoadjuvant chemotherapy was initiated and resulted in substantial tumor shrinkage and intrauterine fetal death. The rare nature of this condition underlines once more the need for a multidisciplinary team to improve the quality of care for this highly special patient collective.
authors.affiliation: Comprehensive Cancer Center - Musculoskeletal Tumors, GIST, Bone and Soft Tissue Sarcoma Program, Clinical Division of Oncology, Department of Internal Medicine I, Sarcoma Platform Austria, Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Schur
authors.forename: J
authors.initials: J
authors.lastname: Wild
authors.forename: G
authors.initials: G
authors.lastname: Amann
authors.forename: W
authors.initials: W
authors.lastname: Köstler
authors.forename: M
authors.initials: M
authors.lastname: Langer
authors.forename: T
authors.initials: T
authors.lastname: Brodowicz
keywords: Ewing's sarcoma; Intrauterine fetal death; Multidisciplinary team approach; Neoadjuvant chemotherapy; Pregnancy