title: Anti-Müllerian hormone as a marker of ovarian reserve in patients with ovarian malignancies who have undergone fertility-preserving surgery and chemotherapy.
abstract: With proper and careful selection of patients, fertility-preserving surgery may be feasible in patients with ovarian malignancies. However, the loss of follicles by oophorectomy and chemotherapy results in decreased ovarian reserve, which consecutively affects reproductive capacity. We evaluated postoperative levels of serum anti-Müllerian hormone (AMH) in women with ovarian malignancies to assess the impact of the fertility-preserving surgery with or without the administration of chemotherapy on ovarian reserve. In 13 patients who underwent the fertility-preserving surgery with (n = 9) or without (n = 4) the administration of chemotherapy, serum AMH levels were measured and compared with serum AMH levels measured in patients undergone cystectomy for benign ovarian tumors as a control. We found that the mean AMH level in the treatment group measured 0.9 ng/mL, which was significantly lower than that measured in the control group (4.70 ± 3.77 ng/mL). The possibility of decreased ovarian reserve occurring in patients with ovarian malignancies following treatment with fertility-preserving surgery with or without the administration of chemotherapy should be considered for fertility planning.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan. akiwase@med.nagoya-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Iwase
authors.forename: Atsuko
authors.initials: A
authors.lastname: Sugita
authors.forename: Wakana
authors.initials: W
authors.lastname: Hirokawa
authors.forename: Maki
authors.initials: M
authors.lastname: Goto
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nakahara
authors.lastname: Bayasula
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kajiyama
authors.forename: Kiyosumi
authors.initials: K
authors.lastname: Shibata
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Nagatomo
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Kikkawa
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D010535:Laparoscopy; D006080:Ovarian Follicle / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000601:surgery; D010052:Ovariectomy
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone