title: [Correlation between long-term proton pump ingibitor use, homocysteine and lipoproteins serum concentrations in patients with comorbidity of ischemic heart disease and acid peptic disease].
abstract: Present article is devoted to the study of the correlation between vitamin B12 serum level, hyperhomocysteinaemia and dyslipidemia. During research there were discovered that the lowest vitamin B12 serum level and the highest homocysteine serum level have been registrated in associated pathology (ischemic heart disease and acid peptic disease according to long-term proton pump inhibitor use) patients. It was shown evident correlation between that changes and dyslipidemia. Тhe complex therapy that includes parenteral B12 supplementation leads to more effective correction of hyperhomocysteinaemia and dyslipidemia in patients with comorbidity of ischemic heart disease and acid peptic disease with long-term use of proton pump inhibitors.
authors.affiliation: Medical Institute of Sumy State University, Department of Family Medicine, Sumy, Ukraine.
authors.forename: A
authors.initials: A
authors.lastname: Zharkova
authors.forename: V
authors.initials: V
authors.lastname: Orlovsky
mesh_terms: D002784:Cholesterol / Q000097:blood; D015897:Comorbidity; D050171:Dyslipidemias / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000188:drug therapy*; D007263:Infusions, Parenteral; D008077:Lipoproteins, LDL / Q000097:blood; D017202:Myocardial Ischemia / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D010437:Peptic Ulcer / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology*; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000139:chemically induced
chemical_list: D008077:Lipoproteins, LDL; D054328:Proton Pump Inhibitors; D006710:Homocysteine; D002784:Cholesterol; D014805:Vitamin B 12