title: The dietary acrylamide intake adversely affects the serum trace element status.
abstract: Acrylamide is an organic chemical which occurs in foods widespreadly consumed in diets worldwide. The purpose of this study was to evaluate the serum trace element levels (Fe, Cu, Zn, Mn, Cr, Se, Co, Ni, V, As, Mg, P, Li, K, Al) in Wistar rats exposed to acrylamide. Acrylamide was administered to the treatment groups at 2 and 5 mg/kg body weight (bw)/day via drinking water for 90 days. Inductively coupled plasma mass spectrometry was used for the determination of serum trace element concentrations. Serum Zn, Se, Co, V and Mg concentrations of 5 mg/kg bw/day acrylamide-treated male rats were lower, whereas serum As concentration was higher than the same parameters of the controls rats. Similarly, serum Zn, Se, Co, V and Mg concentrations were decreased in 5 mg/kg bw/day acrylamide-treated female rats compared with control rats. On the other hand, there were no significant differences between serum Fe, Cu, Mn, Cr, Ni, P, Li, K and Al concentrations of all groups. The results from this study provide evidence that dietary acrylamide intake adversely affects the serum trace elements status.
authors.affiliation: Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. fhumeyray@hotmail.com
authors.forename: Fatma Hümeyra
authors.initials: FH
authors.lastname: Yerlikaya
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Yener
mesh_terms: D020106:Acrylamide / Q000008:administration & dosage / Q000633:toxicity*; D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D003035:Cobalt / Q000097:blood; D004032:Diet; D005260:Female; D008274:Magnesium / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D013058:Mass Spectrometry / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors; D014131:Trace Elements / Q000097:blood*; D014639:Vanadium / Q000097:blood; D015032:Zinc / Q000097:blood
chemical_list: D014131:Trace Elements; D014639:Vanadium; D020106:Acrylamide; D003035:Cobalt; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D012643:Selenium; D008274:Magnesium; D015032:Zinc