title: A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.
abstract: Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era veterans. Hospital Anxiety and Depression Scale (HADS) scores improved by 30.4% in the paroxetine group. Paroxetine may have promise for subthreshold PTSD.
authors.affiliation: VA Mid-Atlantic Mental Illness, Research and Clinical Center, Durham, NC, USA.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Naylor
authors.forename: Trygve R
authors.initials: TR
authors.lastname: Dolber
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Strauss
authors.forename: Jason D
authors.initials: JD
authors.lastname: Kilts
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Strauman
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Bradford
authors.forename: Steven T
authors.initials: ST
authors.lastname: Szabo
authors.forename: Nagy A
authors.initials: NA
authors.lastname: Youssef
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Connor
authors.forename: Jonathan R T
authors.initials: JR
authors.lastname: Davidson
authors.forename: Christine E
authors.initials: CE
authors.lastname: Marx
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000627:therapeutic use*; D010865:Pilot Projects; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy*; D016896:Treatment Outcome; D014728:Veterans / Q000523:psychology*
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors