title: Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO2 as drift gas.
abstract: The use of CO(2) as a massive and polarizable drift gas is shown to greatly improve peak-to-peak resolution (R(p-p) ), as compared with N(2) , for the separation of disaccharides in a Synapt G2 traveling wave ion mobility cell. Near or baseline R(p-p) was achieved for three pairs of sodiated molecules of disaccharide isomers, that is, cellobiose and sucrose (R(p-p)  = 0.76), maltose and sucrose (R(p-p)  = 1.04), and maltose and lactose (R(p-p)  = 0.74). Ion mobility mass spectrometry using CO(2) as the drift gas offers therefore an attractive alternative for fast and efficient separation of isomeric disaccharides.
authors.affiliation: ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas, UNICAMP 13083-970, Campinas, SP, Brazil.
authors.forename: Maíra
authors.initials: M
authors.lastname: Fasciotti
authors.forename: Gustavo B
authors.initials: GB
authors.lastname: Sanvido
authors.forename: Vanessa G
authors.initials: VG
authors.lastname: Santos
authors.forename: Priscila M
authors.initials: PM
authors.lastname: Lalli
authors.forename: Michael
authors.initials: M
authors.lastname: McCullagh
authors.forename: Gilberto F
authors.initials: GF
authors.lastname: de Sá
authors.forename: Romeu J
authors.initials: RJ
authors.lastname: Daroda
authors.forename: Martin G
authors.initials: MG
authors.lastname: Peter
authors.forename: Marcos N
authors.initials: MN
authors.lastname: Eberlin
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry*; D004187:Disaccharides / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D013058:Mass Spectrometry / Q000379:methods*
chemical_list: D004187:Disaccharides; D002245:Carbon Dioxide