title: [Functional morphology of the vagus nerve nuclei changes in the medulla oblongata (N. Ambiguus, N. Dorsalis), induced by influenza a (H(3)N(I)) in experiment].
abstract: Morphological changes of the brain cortex IV-V layers, the structures of n. ambiguus, n. dorsalis and n. vagus ganglia on the model of influenza virus A strains (H3NI) MLD50 in number 50 microns intranasal inoculation in mice aged 6-8 weeks were studied.  For assessment of virus-induced pathology 2 series of experiments were carried out. Electron microscopy, morphometric and histological methods, including by Nissl stain were used. LD dose, daily loss of body weight with access to the so-called "endpoint" determined previously. Experimental period from 48 hours to 12 days.  It is shown that in n.vagus stem structures in the medulla oblongata (n. dorsalis, n. ambiguus) have the mosaic and the polymorphic nature of the changes - signs of influenza virus cytotropic effect, such as swelling, vacuolation, chromatolysis, less pyknosis and hyperchromatosis. In the period of the greatest weight loss and expressed «endpoint» irreversible changes in the stem structures associated with n. vagus - apoptotic nuclei and neurons massive edema, lipofuscin accumulation have taken place.  Results of the study suggest that the parasympathetic nervous system (n. vagus) may be one of the possible route of influenza A virus (H3NI) genomic structures transnerval invasion in the central nervous system during experimental infection.
authors.affiliation: Iv. Javakhishvili Tbilisi State University, A.N. Natishvili Institute of Morphology, Georgia.
authors.forename: L
authors.initials: L
authors.lastname: Gogiashvili
authors.forename: T
authors.initials: T
authors.lastname: Abashidze
authors.forename: Z
authors.initials: Z
authors.lastname: Tsagareli
authors.forename: M
authors.initials: M
authors.lastname: Dgebuadze
authors.forename: T
authors.initials: T
authors.lastname: Kvachadze
mesh_terms: D000818:Animals; D017209:Apoptosis; D002467:Cell Nucleus / Q000473:pathology; D009980:Influenza A virus / Q000472:pathogenicity*; D008526:Medulla Oblongata / Q000473:pathology* / Q000821:virology*; D051379:Mice; D009474:Neurons / Q000473:pathology; D009976:Orthomyxoviridae Infections / Q000209:etiology* / Q000473:pathology; D014630:Vagus Nerve / Q000473:pathology* / Q000821:virology*; D015431:Weight Loss