title: A case of acute prochloraz-manganese complex intoxication treated with extracorporeal elimination.
abstract: OBJECTIVE
  We treated a patient with critical manganese intoxication with vigorous extracorporeal elimination. In this article, we describe the clinical characteristics and treatment modalities of the patient.
  
  
  METHODS
  A 65-year-old man was brought to the emergency room (ER) 5.5 h after ingesting prochloraz-manganese complex. He experienced circulatory collapse and went into a coma without self-breathing on arrival at the ER. Mechanical ventilation was initiated and hemoperfusion, hemodialysis and continuous venovenous hemodiafiltration were performed with the help of norepinephrine. MEASUREMENT AND RESULT: The manganese levels on the first, second and fourth hospital days were 34.1, 23.6 and 12.5 µg/l, respectively. He recuperated from the shock state within 7 hospital days. After 4 critical weeks, the patient regained full consciousness.
  
  
  CONCLUSIONS
  Rigorous extracorporeal elimination by hemoperfusion, hemodialysis and continuous venovenous hemodiafiltration was an effective treatment modality for patients with acute manganese intoxication.
authors.affiliation: Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Hyowook
authors.initials: H
authors.lastname: Gil
authors.forename: Sujin
authors.initials: S
authors.lastname: Seok
authors.forename: Jungrak
authors.initials: J
authors.lastname: Hong
authors.forename: Mihye
authors.initials: M
authors.lastname: Jeong
authors.forename: Saeyong
authors.initials: S
authors.lastname: Hong
mesh_terms: D000368:Aged; D006801:Humans; D007093:Imidazoles / Q000506:poisoning*; D008297:Male; D020149:Manganese Poisoning / Q000097:blood / Q000150:complications / Q000628:therapy*; D009784:Occupational Diseases; D006435:Renal Dialysis / Q000379:methods; D012206:Rhabdomyolysis / Q000209:etiology
chemical_list: D007093:Imidazoles; C045362:prochloraz