title: Common variable immunodeficiency and isosporiasis: first report case.
abstract: We report a severe case of diarrhea in a 62-year-old female HIV-negative patient from whom Giardia lamblia and Isospora belli were isolated. Because unusual and opportunistic infections should be considered as criteria for further analysis of immunological status, laboratory investigations led to a diagnosis of common variable immunodeficiency (CVID). This is the first reported case of isosporiasis in a patient with CVID and illustrates the importance of being aware of a possible link, particularly in relation to primary immunodeficiency.
authors.affiliation: Hospital de Clínicas, Universidade Federal de Uberlândia, Uberlândia, MG.
authors.forename: Gisele Barbosa E
authors.initials: GB
authors.lastname: Silva
authors.forename: Karla Pereira
authors.initials: KP
authors.lastname: Fernandes
authors.forename: Gesmar Rodrigues Silva
authors.initials: GR
authors.lastname: Segundo
mesh_terms: D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis; D003967:Diarrhea / Q000469:parasitology; D005243:Feces / Q000469:parasitology; D005260:Female; D005873:Giardiasis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D021865:Isosporiasis / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications* / Q000175:diagnosis; D012720:Severity of Illness Index