title: Secondary prevention after minor stroke and TIA - usual care and development of a support program.
abstract: BACKGROUND
  Effective methods of secondary prevention after stroke or TIA are available but adherence to recommended evidence-based treatments is often poor. The study aimed to determine the quality of secondary prevention in usual care and to develop a stepwise modeled support program.
  
  
  METHODS
  Two consecutive cohorts of patients with acute minor stroke or TIA undergoing usual outpatient care versus a secondary prevention program were compared. Risk factor control and medication adherence were assessed in 6-month follow-ups (6M-FU). Usual care consisted of detailed information concerning vascular risk factor targets given at discharge and regular outpatient care by primary care physicians. The stepwise modeled support program additionally employed up to four outpatient appointments. A combination of educational and behavioral strategies was employed.
  
  
  RESULTS
  168 patients in the observational cohort who stated their openness to participate in a prevention program (mean age 64.7 y, admission blood pressure (BP): 155/84 mmHg) and 173 patients participating in the support program (mean age 67.6 y, BP: 161/84 mmHg) were assessed at 6 months. Proportions of patients with BP according to guidelines were 50% in usual-care and 77% in the support program (p<0.01). LDL<100 mg/dl was measured in 62 versus 71% (p = 0.12). Proportions of patients who stopped smoking were 50 versus 79% (p<0.01). 72 versus 89% of patients with atrial fibrillation were on oral anticoagulation (p = 0.09).
  
  
  CONCLUSIONS
  Risk factor control remains unsatisfactory in usual care. Targets of secondary prevention were met more often within the supported cohort. Effects on (cerebro-)vascular recurrence rates are going to be assessed in a multicenter randomized trial.
authors.affiliation: Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany. stefanie.leistner@charite.de
authors.forename: Stefanie
authors.initials: S
authors.lastname: Leistner
authors.forename: Steffen
authors.initials: S
authors.lastname: Benik
authors.forename: Inga
authors.initials: I
authors.lastname: Laumeier
authors.forename: Annerose
authors.initials: A
authors.lastname: Ziegler
authors.forename: Gabriele
authors.initials: G
authors.lastname: Nieweler
authors.forename: Christian H
authors.initials: CH
authors.lastname: Nolte
authors.forename: Peter U
authors.initials: PU
authors.lastname: Heuschmann
authors.forename: Heinrich J
authors.initials: HJ
authors.lastname: Audebert
mesh_terms: D000368:Aged; D000553:Ambulatory Care / Q000379:methods*; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000517:prevention & control* / Q000628:therapy*; D008297:Male; D011787:Quality of Health Care; D012307:Risk Factors; D055502:Secondary Prevention / Q000379:methods*; D020521:Stroke / Q000517:prevention & control* / Q000628:therapy*