title: Polymorphisms in regulators of xenobiotic transport and metabolism genes PXR and CAR do not affect multiple myeloma risk: a case-control study in the context of the IMMEnSE consortium.
abstract: The exposure to pesticides and toxic compounds in xenobiotic transport and metabolism genes has been shown to affect risk of developing multiple myeloma (MM). Therefore, we hypothesized that genetic variations in xenobiotic transport and metabolism regulator genes PXR (NR1I2) and CAR (NR1I3) could determine a difference in MM susceptibility. Ten tagging single-nucleotide polymorphisms (SNPs) for PXR and seven for the CAR genes were selected and genotyped in 627 MM cases and 883 controls collected in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortium. None of the 17 SNPs investigated showed significant association with MM risk either alone or when combined in haplotypes. Significant SNP-SNP interactions were not found, neither with 58 previously genotyped polymorphisms in ABC transporters. We can therefore exclude that common genetic variants in the xenobiotic transport and metabolism regulator genes PXR and CAR affect MM risk.
authors.affiliation: Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martino
authors.forename: Juan
authors.initials: J
authors.lastname: Sainz
authors.forename: Rui
authors.initials: R
authors.lastname: Manuel Reis
authors.forename: Victor
authors.initials: V
authors.lastname: Moreno
authors.forename: Gabriele
authors.initials: G
authors.lastname: Buda
authors.forename: Fabienne
authors.initials: F
authors.lastname: Lesueur
authors.forename: Herlander
authors.initials: H
authors.lastname: Marques
authors.forename: Ramón
authors.initials: R
authors.lastname: García-Sanz
authors.forename: Rafael
authors.initials: R
authors.lastname: Ríos
authors.forename: Angelika
authors.initials: A
authors.lastname: Stein
authors.forename: Charles
authors.initials: C
authors.lastname: Dumontet
authors.forename: Federica
authors.initials: F
authors.lastname: Gemignani
authors.forename: Anna
authors.initials: A
authors.lastname: Maria Rossi
authors.forename: Stefano
authors.initials: S
authors.lastname: Landi
authors.forename: Manuel
authors.initials: M
authors.lastname: Jurado
authors.forename: Mario
authors.initials: M
authors.lastname: Petrini
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Jamroziak
authors.forename: Daniele
authors.initials: D
authors.lastname: Campa
authors.forename: Federico
authors.initials: F
authors.lastname: Canzian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D000090702:Constitutive Androstane Receptor; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D011987:Receptors, Steroid / Q000235:genetics / Q000378:metabolism*; D012307:Risk Factors; D015262:Xenobiotics / Q000378:metabolism; D055815:Young Adult
chemical_list: D000090702:Constitutive Androstane Receptor; C000625852:NR1I2 protein, human; C000716327:NR1I3 protein, human; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D015262:Xenobiotics