title: [Frequency of opportunistic infections in children with immune neutropenia and their mothers].
abstract: OBJECTIVE
  Determine the frequency of opportunistic infections among children with immune neutropenia and their mothers.
  
  
  METHODS
  66 mothers and 66 children with immune neutropenia diagnosis were examined for the presence of herpes (HV) and pneumocystic infection. Opportunistic infections markers (IgM, IgG, early and late antigens, virus reproduction) were determined by enzyme immunoassay, immunofluorescence reaction and rapid culture method (vero, u937, human fibroblasts).
  
  
  RESULTS
  Pneumocystosis was the most active infection in the group. Among mothers 26 (39.3%) cases of pneumocystic infection in acute form were detected, among children - 18 (27.3%) cases. Infection occurred only in acute form during primary infection; there were no cases of its reactivation, which is an indication of recent pneumocystosis infection. Analysis of data on detection of acute and recent herpes infections showed that HV infection markers were determined in a relatively large number of mothers and their children: herpes simplex virus - 21.2%, Epstein-Barr virus - 12.0%, cytomegalovirus - 15.0%, Human herpesvirus 6 - 10.6%, Pneumocystis carinii - 21.2%. The data provided give evidence on a possible family pattern of the infection.
  
  
  CONCLUSIONS
  A necessity of examination of mothers and their children suffering from immune neutropenia was shown because the specified opportunistic infections can form intra-family foci. The presence of acute form of infection in mother may be one of the conditions of development of this infection in the child.
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Kalugina
authors.forename: N V
authors.initials: NV
authors.lastname: Karazhas
authors.forename: T N
authors.initials: TN
authors.lastname: Rybalkina
authors.forename: R E
authors.initials: RE
authors.lastname: Bosh'ian
authors.forename: E A
authors.initials: EA
authors.lastname: Mamedova
authors.forename: T V
authors.initials: TV
authors.lastname: Polovtseva
authors.forename: N A
authors.initials: NA
authors.lastname: Finogenova
mesh_terms: D000208:Acute Disease; D000818:Animals; D000946:Antigens, Fungal / Q000097:blood*; D000956:Antigens, Viral / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D002522:Chlorocebus aethiops; D005260:Female; D005347:Fibroblasts / Q000382:microbiology / Q000821:virology; D006564:Herpesviridae / Q000276:immunology; D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D015994:Incidence; D007223:Infant; D009503:Neutropenia / Q000453:epidemiology* / Q000276:immunology* / Q000382:microbiology / Q000821:virology; D009894:Opportunistic Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000821:virology; D045363:Pneumocystis carinii / Q000276:immunology; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D012426:Russia / Q000453:epidemiology; D014709:Vero Cells
chemical_list: D000946:Antigens, Fungal; D000956:Antigens, Viral; D015415:Biomarkers; D007074:Immunoglobulin G; D007075:Immunoglobulin M