title: Undressing the fungal cell wall/cell membrane--the antifungal drug targets.
abstract: Being external, the fungal cell wall plays a crucial role in the fungal life. By covering the underneath cell, it offers mechanical strength and acts as a barrier, thus protecting the fungus from the hostile environment. Chemically, this cell wall is composed of different polysaccharides. Because of their specific composition, the fungal cell wall and its underlying plasma membrane are unique targets for the development of drugs against pathogenic fungal species. The objective of this review is to consolidate the current knowledge on the antifungal drugs targeting the cell wall and plasma membrane, mainly of Aspergillus and Candida species - the most prevalent fungal pathogens, and also to present challenges and questions conditioning the development of new antifungal drugs targeting the cell wall.
authors.affiliation: Unité des Aspergillus, Institut Pasteur, Paris, France.
authors.forename: Rui
authors.initials: R
authors.lastname: Tada
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Latgé
authors.forename: Vishukumar
authors.initials: V
authors.lastname: Aimanianda
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology; D001230:Aspergillus / Q000166:cytology / Q000187:drug effects*; D002175:Candida / Q000166:cytology / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002473:Cell Wall / Q000187:drug effects / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D058990:Molecular Targeted Therapy; D011134:Polysaccharides / Q000502:physiology
chemical_list: D000935:Antifungal Agents; D011134:Polysaccharides