title: Hsp10: anatomic distribution, functions, and involvement in human disease.
abstract: There is growing evidence that molecular chaperones/heat shock proteins are involved in the pathogenesis of a number of human diseases, known as chaperonopathies. A better molecular understanding of the pathogenetic mechanisms is essential for addressing new strategies in diagnostics, therapeutics and clinical management of chaperonopathies, including those in which Hsp10 is involved. This chaperonin has been studied for a long time as a member of the mitochondrial protein-folding machine. However, although in normal cells Hsp10 is mainly localized in the mitochondrial matrix, it has also been found during and after stress in other subcellular compartments, such as cytosol, vesicles and secretory granules, alone or in combination with other proteins. In these extramitochondrial locales, Hsp10 plays an active role in cell signalling. For example, cancer cells often show altered levels of Hsp10, compared to normal cells. Hsp10 may also be found in the extracellular space and in the bloodstream, with a possible immunomodulatory activity. This minireview focuses on some studies to date on the involvement of Hsp10 in human disease pathogenesis.
authors.affiliation: Department of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: David
authors.forename: Fabio
authors.initials: F
authors.lastname: Bucchieri
authors.forename: Simona
authors.initials: S
authors.lastname: Corrao
authors.forename: Anna M
authors.initials: AM
authors.lastname: Czarnecka
authors.forename: Claudia
authors.initials: C
authors.lastname: Campanella
authors.forename: Felicia
authors.initials: F
authors.lastname: Farina
authors.forename: Giovanni
authors.initials: G
authors.lastname: Peri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tomasello
authors.forename: Carmelo
authors.initials: C
authors.lastname: Sciumè
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Modica
authors.forename: Giampiero
authors.initials: G
authors.lastname: La Rocca
authors.forename: Rita
authors.initials: R
authors.lastname: Anzalone
authors.forename: Mario
authors.initials: M
authors.lastname: Giuffrè
authors.forename: Everly
authors.initials: E
authors.lastname: Conway De Macario
authors.forename: Alberto J L
authors.initials: AJ
authors.lastname: Macario
authors.forename: Francesco
authors.initials: F
authors.lastname: Cappello
authors.forename: Giovanni
authors.initials: G
authors.lastname: Zummo
mesh_terms: D000375:Aging / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000378:metabolism*; D018835:Chaperonin 10 / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*
chemical_list: D018835:Chaperonin 10