title: Topology preserving atlas construction from shape data without correspondence using sparse parameters.
abstract: Statistical analysis of shapes, performed by constructing an atlas composed of an average model of shapes within a population and associated deformation maps, is a fundamental aspect of medical imaging studies. Usual methods for constructing a shape atlas require point correspondences across subjects, which are difficult in practice. By contrast, methods based on currents do not require correspondence. However, existing atlas construction methods using currents suffer from two limitations. First, the template current is not in the form of a topologically correct mesh, which makes direct analysis on shapes difficult. Second, the deformations are parametrized by vectors at the same location as the normals of the template current which often provides a parametrization that is more dense than required. In this paper, we propose a novel method for constructing shape atlases using currents where topology of the template is preserved and deformation parameters are optimized independently of the shape parameters. We use an L1-type prior that enables us to adaptively compute sparse and low dimensional parameterization of deformations. We show an application of our method for comparing anatomical shapes of patients with Down's syndrome and healthy controls, where the sparse parametrization of diffeomorphisms decreases the parameter dimension by one order of magnitude.
authors.affiliation: INRIA / ICM, Pitié Salpêtrière Hospital, Paris, France.
authors.forename: Stanley
authors.initials: S
authors.lastname: Durrleman
authors.forename: Marcel
authors.initials: M
authors.lastname: Prastawa
authors.forename: Julie R
authors.initials: JR
authors.lastname: Korenberg
authors.forename: Sarang
authors.initials: S
authors.lastname: Joshi
authors.forename: Alain
authors.initials: A
authors.lastname: Trouvé
authors.forename: Guido
authors.initials: G
authors.lastname: Gerig
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology*; D003198:Computer Simulation; D004314:Down Syndrome / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008953:Models, Anatomic; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity