title: Pharmacologic prophylaxis regimens for acute graft-versus-host disease: past, present and future.
abstract: Abstract Acute graft-versus-host disease (GVHD) has compromised and continues to compromise the benefits associated with allogeneic hematopoietic cell transplant to cure malignant and non-malignant diseases. Pharmacologic interventions to prevent GVHD have emerged as a major objective of research in the immunology and transplant fields. A better understanding of the pathobiology behind the GVHD process has led the way to novel approaches and medications. Here we review the present arsenal of medications used to prevent GVHD, focusing on past experience and the current evidence, and discuss future potential targets.
authors.affiliation: Bone Marrow Transplantation Unit, Rabin Medical Center, Beilinson Hospital and the Sackler School of Medicine, Tel Aviv University, Israel. ronram73@gmail.com
authors.forename: Ron
authors.initials: R
authors.lastname: Ram
authors.forename: Rainer
authors.initials: R
authors.lastname: Storb
mesh_terms: D000208:Acute Disease; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D011292:Premedication
chemical_list: D007166:Immunosuppressive Agents