title: Effect of topiramate on weight gain in patients receiving atypical antipsychotic agents.
abstract: BACKGROUND
  Clinical antipsychotic trials of intervention effectiveness showed that atypical antipsychotics (AAPs) were associated with significant weight gain and glucose intolerance. A few trials have shown topiramate to reduce weight gain in patients receiving AAPs, although this benefit has not been present in all trials.
  
  
  OBJECTIVE
  This study aimed to determine topiramate therapy's impact on weight gain in patients receiving AAPs.
  
  
  METHODS
  A systematic literature search of MEDLINE (1948 to July 8, 2011) and Cochrane CENTRAL (4th Quarter 2011) was conducted.
  
  
  METHODS
  Eight trials (n = 336 participants) met our inclusion criteria: randomized controlled trial, evaluated topiramate in patients taking AAPs, and reported weight change during the treatment course.
  
  
  METHODS
  Two investigators (S.M. and C.I.C.) used a standardized data abstraction tool to independently collect data, with disagreement resolved through discussion. The difference between the mean weight in the topiramate and control groups was calculated as the weighted mean difference with accompanying 95% confidence interval. A random effect model was used for all analyses.
  
  
  RESULTS
  Upon meta-analysis, we found that patients receiving topiramate lost weight or had attenuated weight gain compared to control patients (weighted mean difference, -2.83 kg; 95% confidence interval, -4.62 to -1.03).
  
  
  CONCLUSIONS
  Our meta-analysis shows that using topiramate can prevent or reduce weight gain associated with AAPs.
authors.affiliation: Department of Preventive Medicine, Griffin Hospital, Derby, CT, USA.
authors.forename: Shamail
authors.initials: S
authors.lastname: Mahmood
authors.forename: Ian
authors.initials: I
authors.lastname: Booker
authors.forename: Judy
authors.initials: J
authors.lastname: Huang
authors.forename: Craig I
authors.initials: CI
authors.lastname: Coleman
mesh_terms: D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D000077236:Topiramate; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D019440:Anti-Obesity Agents; D014150:Antipsychotic Agents; D000077236:Topiramate; D005632:Fructose