title: AMIGAS: a multicity, multicomponent cervical cancer prevention trial among Mexican American women.
abstract: BACKGROUND
  Considerable efforts have been undertaken in the United States to reduce cervical cancer incidence and mortality by increasing screening; however, disparities in screening rates continue to exist among certain racial and ethnic minority groups. The objective of the current study was to determine the effectiveness of a lay health worker-delivered intervention-AMIGAS (Ayudando a las Mujeres con Informacion, Guia, y Amor para su Salud [helping women with information, guidance, and love for their health])-to increase Papanicolaou (Pap) test screening among 3 populations of women of Mexican origin.
  
  
  METHODS
  Six hundred thirteen women of Mexican origin in 3 treatment sites were randomized among 4 study arms: the full AMIGAS program with a video and a flip chart (n = 151), the AMIGAS program without the video (n = 154), the AMIGAS program without the flip chart (n = 155), and a usual care control group (n = 153). Six months after enrollment, women were surveyed and reported whether or not they had been screened.
  
  
  RESULTS
  Women in any of the intervention arms were statistically significantly more likely to report being screened than those in the usual care group in both an intent-to-treat analysis and a per-protocol analysis. In the intent-to-treat analysis, 25% of women in the control group and 52% in the full AMIGAS program group reported having had Pap tests (P < .001); in the per-protocol analysis, the percentages were 29% and 62%, respectively (P < .001).
  
  
  CONCLUSIONS
  AMIGAS was effective in increasing Pap test screening among women of Mexican descent when used in a 1-to-1 setting. Future research should compare the 1-on-1 intervention with the group-based intervention.
authors.affiliation: Texas Tech Paul L. Foster School of Medicine, El Paso, TX 79905, USA. theresa.byrd@ttuhsc.edu
authors.forename: Theresa L
authors.initials: TL
authors.lastname: Byrd
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Wilson
authors.forename: Judith Lee
authors.initials: JL
authors.lastname: Smith
authors.forename: Gloria
authors.initials: G
authors.lastname: Coronado
authors.forename: Sally W
authors.initials: SW
authors.lastname: Vernon
authors.forename: Maria Eugenia
authors.initials: ME
authors.lastname: Fernandez-Esquer
authors.forename: Beti
authors.initials: B
authors.lastname: Thompson
authors.forename: Melchor
authors.initials: M
authors.lastname: Ortiz
authors.forename: David
authors.initials: D
authors.lastname: Lairson
authors.forename: Maria E
authors.initials: ME
authors.lastname: Fernandez
mesh_terms: D000328:Adult; D003150:Community Health Workers; D055088:Early Detection of Cancer / Q000009:adverse effects; D005260:Female; D006801:Humans; D017058:Mexican Americans; D065006:Papanicolaou Test; D010342:Patient Acceptance of Health Care / Q000208:ethnology; D010353:Patient Education as Topic; D057566:Self Report; D014481:United States / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000208:ethnology / Q000517:prevention & control* / Q000523:psychology; D014626:Vaginal Smears; D014741:Video Recording; D055815:Young Adult