title: Expression of the coxsackie and adenovirus receptor in human lung cancers.
abstract: The aim of this study is to elucidate the relation between expression of coxsackie and adenovirus receptor (CAR) and formation of lung cancer. We investigated the expression of CAR by immunohistochemistry, Western blot and real-time RT-PCR in 120 lung cancers. We found that CAR expression in tumor tissues was significantly higher than that in normal lung tissues. CAR expression had a correlation with the histological grade of lung squamous cell carcinoma; however, there was no relationship between the CAR expression and the other clinical pathological features. In vitro, silencing or overexpression of CAR could significantly inhibit or promote colony formation, cell adhesion, and invasion in A549 cells. Our findings demonstrated that CAR may play an essential role in the formation of lung cancer.
authors.affiliation: Department of Health and Environment, Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control for Environment and Food Safety, No. 1, Dali Road, Tianjin, 300050, People's Republic of China.
authors.forename: Zhaoli
authors.initials: Z
authors.lastname: Chen
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Jingran
authors.initials: J
authors.lastname: Sun
authors.forename: Ankang
authors.initials: A
authors.lastname: Gu
authors.forename: Min
authors.initials: M
authors.lastname: Jin
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Shen
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Qiu
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Xinwei
authors.initials: X
authors.lastname: Wang
authors.forename: Zhongli
authors.initials: Z
authors.lastname: Zhan
authors.forename: Jun-Wen
authors.initials: JW
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D034622:RNA Interference; D034741:RNA, Small Interfering
chemical_list: D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D034741:RNA, Small Interfering