title: Life course association of maternal smoking during pregnancy and offspring's height: data from the 1993 Pelotas (Brazil) birth cohort.
abstract: OBJECTIVE
  To evaluate the effect of (1) maternal smoking during pregnancy; and (2) partner smoking on offspring's height in infancy, childhood, and adolescence.
  
  
  METHODS
  All hospital live births from 1993 (5,249) were identified, and these infants were followed up at several ages. Height for age, expressed as z-scores using the World Health Organization growth curves, was measured at all follow-up visits. Maternal smoking during pregnancy was collected retrospectively at birth and analyzed as number of cigarettes/day smoked categorized in four categories (never smoked, <10, 10-19, and ≥ 20 cigarettes/day). Partner smoking was analyzed as a dichotomous variable (No/Yes). Unadjusted and adjusted analyses were performed by use of linear regression.
  
  
  RESULTS
  The prevalence of self-reported maternal smoking during pregnancy was 33.5%. In the crude analysis, the number of cigarettes/day smoked by the mother during pregnancy negatively affected offspring's height in infancy, childhood, and adolescence. After adjustment for confounders and mediators, this association remained statistically significant, although the magnitude of the regression coefficients was reduced. Paternal smoking was not associated with offspring's height in the adjusted analyses.
  
  
  CONCLUSIONS
  In addition to the well-known harmful effects of smoking, maternal smoking during pregnancy negatively affects offspring's height. Public health policies aimed at continuing to reduce the prevalence of maternal smoking during pregnancy must be encouraged.
authors.affiliation: Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil. jeovanymm@yahoo.es
authors.forename: Jeovany
authors.initials: J
authors.lastname: Martínez-Mesa
authors.forename: Ana M B
authors.initials: AM
authors.lastname: Menezes
authors.forename: David A
authors.initials: DA
authors.lastname: González
authors.forename: Bernardo L
authors.initials: BL
authors.lastname: Horta
authors.forename: Alicia
authors.initials: A
authors.lastname: Matijasevich
authors.forename: Denise P
authors.initials: DP
authors.lastname: Gigante
authors.forename: Pedro C
authors.initials: PC
authors.lastname: Hallal
mesh_terms: D000293:Adolescent; D001827:Body Height; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012907:Smoking / Q000009:adverse effects*