title: Prognostic impact of coronary microcirculation abnormalities in systemic sclerosis: a prospective study to evaluate the role of non-invasive tests.
abstract: BACKGROUND
  Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome.
  
  
  METHODS
  Forty-one SSc patients, asymptomatic for coronary artery disease, were tested for coronary flow velocity reserve (CFR) by transthoracic-echo-Doppler with adenosine infusion (A-TTE) and for left ventricular wall motion abnormalities (WMA) by dobutamine stress echocardiography (DSE). Myocardial multi-detector computed tomography (MDCT) enabled the presence of epicardial stenosis, which could interfere with the accuracy of the tests, to be excluded. Patient survival rate was assessed over a 6.7-±3.5-year follow-up.
  
  
  RESULTS
  Nineteen out of 41 (46%) SSc patients had a reduced CFR (≤2.5) and in 16/41 (39%) a WMA was observed during DSE. Furthermore, 13/41 (32%) patients showed pathological CFR and WMA. An inverse correlation between wall motion score index (WMSI) during DSE and CFR value (r=-0.57, P<0.0001) was observed; in addition, CFR was significantly reduced (2.21±0.38) in patients with WMA as compared to those without (2.94±0.60) (P<0.0001). In 12 patients with abnormal DSE, MDCT was used to exclude macrovasculopathy. During a 6.7-±3.5-year follow-up seven patients with abnormal coronary functional tests died of disease-related causes, compared to only one patient with normal tests.
  
  
  CONCLUSIONS
  A-TTE and DSE tests are useful tools to detect non-invasively pre-clinical microcirculation abnormalities in SSc patients; moreover, abnormal CFR and WMA might be related to a worse disease outcome suggesting a prognostic value of these tests, similar to other myocardial diseases.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Vacca
authors.forename: Roberta
authors.initials: R
authors.lastname: Montisci
authors.forename: Pietro
authors.initials: P
authors.lastname: Garau
authors.forename: Paolo
authors.initials: P
authors.lastname: Siotto
authors.forename: Matteo
authors.initials: M
authors.lastname: Piga
authors.forename: Alberto
authors.initials: A
authors.lastname: Cauli
authors.forename: Massimo
authors.initials: M
authors.lastname: Ruscazio
authors.forename: Luigi
authors.initials: L
authors.lastname: Meloni
authors.forename: Sabino
authors.initials: S
authors.lastname: Iliceto
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mathieu
mesh_terms: D000328:Adult; D000368:Aged; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012595:Scleroderma, Systemic / Q000000981:diagnostic imaging*