title: Enantioselective synthesis of 2-arylbicyclo[1.1.0]butane carboxylates.
abstract: The rhodium-catalyzed reaction of 2-diazo-5-arylpent-4-enoates can be controlled by the appropriate choice of catalyst and catalyst loading to form either 2-arylbicyclo[1.1.0]butane carboxylates or cyclohexene derivatives. Both products are produced in a highly diastereoselective manner, with 2-arylbicyclo[1.1.0]butane carboxylates preferentially formed under low catalyst loadings. When the reaction is catalyzed by Rh(2)(R-BTPCP)(4), the 2-arylbicyclo[1.1.0]butane carboxylates are generated with high levels of asymmetric induction (70-94% ee).
authors.affiliation: Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
authors.forename: Changming
authors.initials: C
authors.lastname: Qin
authors.forename: Huw M L
authors.initials: HM
authors.lastname: Davies