title: A pharmacodynamic comparison study of different botulinum toxin type A preparations.
abstract: BACKGROUND
  Because more botulinum toxin (BoNT) preparations have become available worldwide, there is a clinical need to compare the pharmacologic profiles of these products.
  
  
  OBJECTIVE
  We compared three different preparations: onabotulinumtoxinA (ona-BoNT/A), abobotulinumtoxinA (abo-BoNT/A), and Neuronox (neu-BoNT/A), in a mouse model using a digit abduction scoring (DAS) assay.
  
  
  METHODS
  The efficacy, duration of effect, and safety margin of each preparation was determined after delivering a single injection to the right gastrocnemius (0-240 U/kg body weight of neu-BoNT/A or ona-BoNT/A; 0-600 Speywood Units/kg body weight of abo-BoNT/A).
  
  
  RESULTS
  Neu-BoNT/A (intramuscular (IM) median effective dose (ED(50) ) 11.2 ± 2.7 U/kg) and ona-BoNT/A (IM ED(50)  11.9 ± 2.4 U/kg) had similar effects in terms of muscle weakness at significantly lower doses than abo-BoNT/A (IM ED(50)  41.2 ± 2.4 U/kg; p < .001). The safety margin (ratio between IM ED(50)  and IM median lethal dose (LD(50) )) of neu-BoNT/A (10.7 ± 2.6 U/kg) was also similar to that of ona-BoNT/A (10.3 ± 1.3 U/kg) but significantly higher than that of abo-BoNT/A (5.9 ± 0.4 U/kg; p < .02). Neu-BoNT/A and ona-BoNT/A also produced comparable patterns of DAS response and body weight recovery by day 29.
  
  
  CONCLUSIONS
  Neu-BoNT/A and ona-BoNT/A may be interchangeable based on a simple dose ratio.
authors.affiliation: Microbial Toxin Research Institute, Medytox Inc., Chungbuk, Korea.
authors.forename: Sung-Beom
authors.initials: SB
authors.lastname: Kim
authors.forename: Bhupal
authors.initials: B
authors.lastname: Ban
authors.forename: Keun-Suk
authors.initials: KS
authors.lastname: Jung
authors.forename: Gi-Hyeok
authors.initials: GH
authors.lastname: Yang
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D019274:Botulinum Toxins, Type A / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D008813:Mice, Inbred ICR; D018908:Muscle Weakness / Q000139:chemically induced; D018482:Muscle, Skeletal / Q000187:drug effects; D009498:Neurotoxins / Q000494:pharmacology*
chemical_list: D009498:Neurotoxins; D019274:Botulinum Toxins, Type A; C542869:abobotulinumtoxinA