title: Predictors of acquired perforating dermatosis in uremic patients on hemodialysis: a case-control study.
abstract: OBJECTIVE
  The purpose of this study was to identify the predictors of acquired perforating dermatosis (APD) in patients on maintenance hemodialysis (HD).
  
  
  METHODS
  A case-control study was performed at our outpatient HD center between January 1, 2000 and March 31, 2011. Patients on HD with APD were matched (1 : 2) for gender and age with controls on HD. Conditional logistic regression was used to identify factors associated with APD.
  
  
  RESULTS
  A total of 19 patients with APD and 38 age and gender matched patients were enrolled in the study. Univariate logistic regression showed that APD was significantly associated with diabetes mellitus (DM), reduced levels of intact parathyroid hormone (iPTH) and albumin (Alb), reduced dialysis adequacy (Kt/V) and urea reduction rate (URR), and elevated levels of high-sensitivity C-reactive protein (hsCRP). Multivariate logistic regression identified reduced iPTH (hazard ratio (HR): 0.983; P = 0.026) and Alb (HR: 0.099; P = 0.047) and elevated hsCRP (HR: 1.210, P = 0.024) as risk factors for APD.
  
  
  CONCLUSIONS
  iPTH, hsCRP, and Alb are predictors for APD in HD patients.
authors.affiliation: Department of Nephrology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, Taiwan.
authors.forename: Cheng-Hao
authors.initials: CH
authors.lastname: Weng
authors.forename: Ching-Chih
authors.initials: CC
authors.lastname: Hu
authors.forename: Shir-Hwa
authors.initials: SH
authors.lastname: Ueng
authors.forename: Chun-Chen
authors.initials: CC
authors.lastname: Yu
authors.forename: Chung-Yee
authors.initials: CY
authors.lastname: Hui
authors.forename: Ja-Liang
authors.initials: JL
authors.lastname: Lin
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Yang
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Hung
authors.forename: Ching-Wei
authors.initials: CW
authors.lastname: Hsu
authors.forename: Tzung-Hai
authors.initials: TH
authors.lastname: Yen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011237:Predictive Value of Tests; D006435:Renal Dialysis / Q000009:adverse effects* / Q000639:trends; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism; D012871:Skin Diseases / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D014511:Uremia / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology
chemical_list: D010281:Parathyroid Hormone; D012709:Serum Albumin