title: Thyroid in 2012: Advances in thyroid development, hormone action and neoplasia.
abstract: In 2012, we learned that functional thyroid tissue can be generated in vitro, and that thyroid hormones stimulate autophagy. Patients with defects in TRα have been identified, and di-iodothyropropionic acid has been shown to ameliorate MCT8 deficiency. Finally, we found that gene expression profiling can identify benign thyroid nodules.
authors.affiliation: University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, UK. kkc1@medschl.cam.ac.uk
authors.forename: V Krishna K
authors.initials: VK
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D001343:Autophagy; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000235:genetics / Q000628:therapy*; D027501:Monocarboxylic Acid Transporters / Q000235:genetics / Q000378:metabolism; D011988:Receptors, Thyroid Hormone / Q000235:genetics / Q000378:metabolism; D027981:Symporters; D013961:Thyroid Gland / Q000166:cytology* / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*
chemical_list: D027501:Monocarboxylic Acid Transporters; D011988:Receptors, Thyroid Hormone; C090735:SLC16A2 protein, human; D027981:Symporters; D013963:Thyroid Hormones