title: Synthesis and in vitro antimicrobial evaluation of pyrazolyl-quinazolin-4(3H)-ones.
abstract: A new series of 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl -3-[(1-phenyl-5-substituted phenyl)-5-hydro-1H-pyrazol-3-yl-amino]-6,8-dibromoquinazolin-4(3H)-ones C1-13 have been synthesized by the reaction of 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-substituted phenyl chromene amido-6,8-dibromo-quinazolin-4(3H)-ones with phenylhydrazine in the presence of glacial acetic acid. The chalcones B1-13 have been synthesized by the condensation of 2-[2-(2, 6-dichloro phenyl)amino]phenylmethyl-3-acetamido-6,8-dibromoquinazolin-4(3H)-one A with different substituted aromatic aldehydes. The structures of newly synthesized compounds have been confirmed on the basis of their elemental analysis and spectral data: IR, 'H NMR, (13)C NMR. All the compounds have been screened for antibacterial and antifungal activity.
authors.affiliation: Department of Chemistry, Veer Narmad South Gujarat University, Surat-395007, India. drnavin@satyam.net.in
authors.forename: Navin B
authors.initials: NB
authors.lastname: Patel
authors.forename: Asif R
authors.initials: AR
authors.lastname: Shaikh
authors.forename: Gaman G
authors.initials: GG
authors.lastname: Barat
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D052999:Quinazolinones