title: Associations of oxidative balance-related exposures with incident, sporadic colorectal adenoma according to antioxidant enzyme genotypes.
abstract: OBJECTIVE
  Previous research found inverse associations between oxidative balance and risk of colorectal adenoma. However, these measures were limited to extrinsic (dietary and lifestyle) exposures and did not account for intrinsic factors, specifically antioxidant enzymes responsible for cellular defense against oxidative stress. We investigated whether the association between an oxidative balance score (OBS) and colorectal adenoma may vary according to polymorphisms in genes that encode three antioxidant enzymes: Manganese superoxide dismutase (SOD2), catalase (CAT), and glutathione-S-transferase P1 (GSTP1).
  
  
  METHODS
  Using data pooled from three colonoscopy-based case-control studies of incident, sporadic colorectal adenoma, we constructed an OBS reflecting pro- and antioxidant exposures. We used multivariable logistic regression to assess whether the association between the OBS and colorectal adenoma differed according to polymorphisms in the genes encoding the antioxidant enzymes.
  
  
  RESULTS
  OBS was inversely associated with colorectal adenoma; adenoma risk was not associated with the genetic polymorphisms, and there was no consistent pattern of effect modification by individual genotypes or combined gene scores.
  
  
  CONCLUSIONS
  Variations in the antioxidant enzyme genes SOD2, CAT, and GSTP1 do not seem to substantially modify associations of environmental exposures related to oxidative balance with risk for sporadic colorectal adenoma.
authors.affiliation: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
authors.forename: Julia
authors.initials: J
authors.lastname: Labadie
authors.forename: Michael
authors.initials: M
authors.lastname: Goodman
authors.forename: Bharat
authors.initials: B
authors.lastname: Thyagarajan
authors.forename: Myron
authors.initials: M
authors.lastname: Gross
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Veronika
authors.initials: V
authors.lastname: Fedirko
authors.forename: Roberd M
authors.initials: RM
authors.lastname: Bostick
mesh_terms: D000236:Adenoma / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000235:genetics; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008910:Minnesota / Q000453:epidemiology; D018384:Oxidative Stress / Q000235:genetics; D011110:Polymorphism, Genetic; D017382:Reactive Oxygen Species; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000235:genetics; D000099156:Superoxide Dismutase 2
chemical_list: D000975:Antioxidants; D002374:Catalase; D051549:Glutathione S-Transferase pi; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2