title: Complement and mannose-binding lectin 2 polymorphism in meningococcal disease.
abstract: BACKGROUND
  Meningococcal disease is a leading cause of death due to infection in children. Differences in susceptibility and disease progression between children are unknown. The complement system plays a key role in the innate immunity against N. meningitides and could explain that differences in the response of individuals. The aim of this study was to evaluate the occurrence of complement system deficiencies and MBL2 polymorphism in patients with previous meningococcal disease.
  
  
  METHODS
  We evaluated 40 children with confirmed previous diagnosis of any form of meningococcal disease and performed quantification analysis of the complement system; C3, C4, and CH50, as well the analysis of the polymorphism of the MBL2 gene.
  
  
  RESULTS
  The major deficiency was found for C4 (27.5%) followed by C3 and CH50 (2.5%). Genotyping of MBL2 showed 21 cases of homozygous wild type allele named AA, (55.3%), 14 cases heterozygous, AO (36.8%), and 3 homozygous variant alleles, OO, (7.9%).
  
  
  CONCLUSIONS
  Complement deficiency and polymorphism in the MBL2 gene are possible explanations for the development of meningococcal disease in some patients. Evaluation of complement could be suggested for individuals affected by this serious disease.
authors.affiliation: Federal University of Pernambuco (UFPE), Brazil. albertodebarroslima@bol.com.br
authors.forename: Alberto
authors.initials: A
authors.lastname: Lima Filho
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Carmo
authors.forename: Maria
authors.initials: M
authors.lastname: Cavalcanti
authors.forename: Luydson
authors.initials: L
authors.lastname: Vasconcelos
authors.forename: Patricia
authors.initials: P
authors.lastname: Moura
authors.forename: Almerinda
authors.initials: A
authors.lastname: Silva
authors.forename: Emanuel
authors.initials: E
authors.lastname: Sarinho
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008585:Meningitis, Meningococcal / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D037601:Mannose-Binding Lectin; D003165:Complement System Proteins