title: A new mild method for the C-acylation of ketone enolates. A convenient synthesis of β-keto-esters, -thionoesters, and -thioesters.
abstract: A new method for ketone enolate C-acylation is described which utilizes alkyl pentafluorophenylcarbonates, thiocarbonates, and thionocarbonates as the reactive acylating agents, and MgBr(2)·Et(2)O, DMAP, and i-Pr(2)NEt as the reagents for enolization. A wide range of ketones have been observed to undergo clean C-acylation via this protocol.
authors.affiliation: The School of Chemistry and Chemical Engineering, and the CCRCB, Queen's University Belfast, Stranmillis Road, Belfast BT9 5AG, Northern Ireland, UK. k.j.hale@qub.ac.uk
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Hale
authors.forename: Milosz
authors.initials: M
authors.lastname: Grabski
authors.forename: Jakub T
authors.initials: JT
authors.lastname: Flasz