title: Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase.
abstract: This study showed the potential of resveratrol to inhibit the expression and activity of interferon-γ (IFN-γ)-induced indoleamine 2,3-dioxygenase (IDO) in bone marrow-derived dendritic cells (BMDCs). The mechanism of suppression was associated with the activity of Janus kinase/signal transducers and activators of transcription (JAK/STAT) and protein kinase Cδ (PKCδ). In addition, resveratrol-mediated IDO suppression in IFN-γ-stimulated BMDCs appears to play a pivotal role in anti-tumor activity through the regulation of CD8(+) T cell polarization and cytotoxic T lymphocyte (CTL) activity. Systemic administration of resveratrol suppressed tumor growth in EG7 thymoma-bearing mice in an IDO-dependent manner. Taken together, resveratrol not only regulates immune response through the regulation of IDO in a JAK/STAT1- and PKCδ-dependent manner, but also modulates the IDO-mediated immune tolerance in EG7 thymoma.
authors.affiliation: Department of Microbiology and Immunology, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam-do 626-870, South Korea.
authors.forename: Kyung Tae
authors.initials: KT
authors.lastname: Noh
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Chae
authors.forename: Sung Hak
authors.initials: SH
authors.lastname: Chun
authors.forename: In Duk
authors.initials: ID
authors.lastname: Jung
authors.forename: Hyun Kyu
authors.initials: HK
authors.lastname: Kang
authors.forename: Yeong-Min
authors.initials: YM
authors.lastname: Park
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D045744:Cell Line, Tumor; D003713:Dendritic Cells / Q000276:immunology*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000037:antagonists & inhibitors*; D053612:Janus Kinases / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D000077185:Resveratrol; D050794:STAT1 Transcription Factor / Q000378:metabolism; D013267:Stilbenes / Q000008:administration & dosage*; D019139:Tumor Escape / Q000187:drug effects*
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D050794:STAT1 Transcription Factor; D013267:Stilbenes; D053612:Janus Kinases; D051057:Proto-Oncogene Proteins c-akt; D000077185:Resveratrol