title: Rapid immunization scheme for spouses of individuals estabilished as hepatitis B carriers during premarital tests.
abstract: BACKGROUND
  The aim of this study was to monitor the cases identified as hepatitis B carriers during premarital tests, to vaccinate their prospective spouses with a rapid vaccination scheme, and to compare the anti-HBs responses with the traditional vaccination scheme.
  
  
  METHODS
  Blood samples of 1250 couple spouses were tested for HBsAg and anti-HBs. HBsAg positive cases' fiancées which were found HBV negative were administered a rapid three-dose vaccination scheme on days 0, 7, and 21. Forty controls with similar age and gender were also were administered three doses of the same vaccine.
  
  
  RESULTS
  Out of 1250 cases (625 couples), 46 (3.6%) were HBsAg positive, and 40 of them aged between 18 and 39 were admitted to the rapid vaccination program.
  
  
  CONCLUSIONS
  Upon determination of HBsAg positivity in premarital tests, a rapid vaccination program provides early protection, but the 6th and 12th month vaccinations are also required. Anti-HBs response should be monitored.
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Manisa State Hospital, Manisa, Turkey.
authors.forename: Selma
authors.initials: S
authors.lastname: Tosun
authors.forename: Murat
authors.initials: M
authors.lastname: Yücetürk
authors.forename: Aydın Bilal
authors.initials: AB
authors.lastname: Dönmez
authors.forename: Turan
authors.initials: T
authors.lastname: Gündüz
mesh_terms: D000293:Adolescent; D000328:Adult; D002353:Carrier State / Q000276:immunology*; D005260:Female; D006509:Hepatitis B / Q000276:immunology* / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D008297:Male; D011291:Premarital Examinations / Q000379:methods*; D018454:Spouses; D014611:Vaccination / Q000379:methods*; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines