title: Impact of genetic targets on prostate cancer therapy.
abstract: Given the global incidence of prostate cancer and its sociological impact, it remains a challenging disease to clinicians and researchers alike. In the last few years several new drugs have been added to the armamentarium of prostate cancer therapy and offers survival benefit to patients with prostate cancer. However, effective drugs are still needed that offer extended survival benefit and alter the natural history of the disease. Recent efforts have focused on better understanding the underlying biology and genetic heterogeneity of the disease and identified novel targets that can be utilized for drug development and therapeutics in the future. In this review we present an overview of the genetic landscape of prostate cancer, novel targets in the prostate cancer therapy and the results of key clinical trials of these novel drugs.
authors.affiliation: Division of Hematology-Oncology, Penn State University, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Sheikh
authors.forename: Junaid
authors.initials: J
authors.lastname: Abdulghani
authors.forename: Suhail
authors.initials: S
authors.lastname: Ali
authors.forename: Raghu
authors.initials: R
authors.lastname: Sinha
authors.forename: Alan
authors.initials: A
authors.lastname: Lipton
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D006801:Humans; D008297:Male; D014411:Neoplastic Stem Cells / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors