title: Antimicrobial activity and surface properties of an acrylic resin containing a biocide polymer.
abstract: OBJECTIVE
  To evaluate the antimicrobial activity and surface properties of an acrylic resin containing the biocide polymer poly (2-tert-butylaminoethyl) methacrylate (PTBAEMA).
  
  
  BACKGROUND
  Several approaches have been proposed to prevent oral infections, including the incorporation of antimicrobial agents to acrylic resins.
  
  
  METHODS
  Specimens of an acrylic resin (Lucitone 550) were divided into two groups: 0% (control) and 10% PTBAEMA. Antimicrobial activity was assessed by adherence assay of one of the microorganisms, Staphylococcus aureus, Streptococcus mutans and Candida albicans. Surface topography was characterised by atomic force microscopy and wettability properties determined by contact angle measurements.
  
  
  RESULTS
  Data of viable cells (log (CFU + 1)/ml) for S. aureus (control: 7.9 ± 0.8; 10%: 3.8 ± 3.3) and S. mutans (control: 7.5 ± 0.7; 10%: 5.1 ± 2.7) showed a significant decrease with 10% of PTBAEMA (Mann-Whitney, p < 0.05). For C. albicans (control: 6.6 ± 0.2; 10%: 6.6 ± 0.4), there was no significant difference between control and 10% of PTBAEMA (Kruskal-Wallis, p > 0.05). Incorporating 10% PTBAEMA increased surface roughness and decreased contact angles.
  
  
  CONCLUSIONS
  Incorporating 10% PTBAEMA into acrylic resins increases wettability and roughness of acrylic resin surface; and decreases the adhesion of S. mutans and S. aureus on acrylic surface, but did not exhibit antimicrobial effect against C. albicans.
authors.affiliation: Department of Dental Materials and Prosthodontics, Araraquara Dental School, Univ Estadual Paulista - UNESP, Araraquara, São Paulo, Brazil.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Compagnoni
authors.forename: Ana C
authors.initials: AC
authors.lastname: Pero
authors.forename: Stella M M
authors.initials: SM
authors.lastname: Ramos
authors.forename: Juliê
authors.initials: J
authors.lastname: Marra
authors.forename: André G
authors.initials: AG
authors.lastname: Paleari
authors.forename: Larissa S
authors.initials: LS
authors.lastname: Rodriguez
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D058491:Bacterial Load / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D015169:Colony Count, Microbial; D003764:Dental Materials / Q000737:chemistry*; D004202:Disinfectants / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry* / Q000494:pharmacology; D050296:Microbial Viability / Q000187:drug effects; D018625:Microscopy, Atomic Force; D013211:Staphylococcus aureus / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects; D013499:Surface Properties; D017155:Wettability
chemical_list: D000180:Acrylic Resins; D000890:Anti-Infective Agents; D003764:Dental Materials; D004202:Disinfectants; D008689:Methacrylates; C522816:poly(2-(tert-butylamino)ethyl methacrylate); C040291:Lucitone
keywords: acrylic resins; antimicrobial; roughness; wetting