title: Growth hormone therapy and craniofacial bones: a comprehensive review.
abstract: Growth hormone (GH) has significant effects on linear bone growth, bone mass and bone metabolism. The primary role of GH supplementation in children with GH deficiency, those born small for gestational age or with other types of disorders in somatic development is to increase linear growth. However, GH therapy seems to elicit varying responses in the craniofacial region. Whereas the effects of GH administration on somatic development are well documented, comparatively little is known of its effects on the craniofacial region. The purpose of this review was to search the literature and compile results from both animal and human studies related to the impact of GH on craniofacial growth.
authors.affiliation: info@orthosmile.gr
authors.forename: G
authors.initials: G
authors.lastname: Litsas
mesh_terms: D000367:Age Factors; D001846:Bone Development / Q000187:drug effects; D005147:Facial Bones / Q000187:drug effects* / Q000254:growth & development; D019382:Human Growth Hormone / Q000172:deficiency / Q000627:therapeutic use*; D006801:Humans; D008445:Maxillofacial Development / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D012886:Skull / Q000187:drug effects* / Q000254:growth & development
chemical_list: D019382:Human Growth Hormone
keywords: craniofacial growth; growth hormone; growth hormone deficiency