title: Rare presentation of Rosai-Dorfman disease mimicking a cervical intramedullary spinal cord tumor.
abstract: BACKGROUND
  Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy, is a rare, benign, lymphoproliferative disorder that commonly manifests as a massive painless cervical lymphadenopathy with associated fever and weight loss. Central nervous system involvement is extremely rare, and cervical spinal cord manifestation has not been reported.
  
  
  METHODS
  A 76-year-old man presented with a 10-week history of right hemiparesis. Magnetic resonance imaging identified an enhancing cervical intramedullary lesion consistent with a primary spinal cord tumor.
  
  
  RESULTS
  Histopathology revealed intramedullary histiocytosis.
  
  
  CONCLUSIONS
  This cervical presentation of Rosai-Dorfman disease with central nervous system involvement suggests variation in the clinical manifestations of the disease, necessitating greater surgical awareness.
authors.affiliation: Neurosurgical Department, Wollongong Hospital, University of Wollongong, Wollongong, New South Wales, Australia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Molla
authors.affiliation: Anatomical Pathology Department, Liverpool Hospital, Liverpool, New South Wales, Australia.
authors.forename: Tamadur
authors.initials: T
authors.lastname: Mahasneh
authors.affiliation: Private Neurosurgical Practice, New South Wales, Australia.
authors.forename: Sue-Ellen
authors.initials: SE
authors.lastname: Holmes
authors.affiliation: Neurosurgical Department, Wollongong Hospital, University of Wollongong, Wollongong, New South Wales, Australia. Electronic address: braindoc@tpg.com.au.
authors.forename: Darweesh
authors.initials: D
authors.lastname: Al-Khawaja
mesh_terms: D000368:Aged; D001706:Biopsy; D002574:Cervical Vertebrae; D003937:Diagnosis, Differential; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000473:pathology
keywords: Lymphadenopathy; Rosai-Dorfman disease; Sinus histiocytosis; Spinal cord