title: Superfamily 1 helicases .
abstract: Superfamily 1 helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along, and concomitant unwinding of, DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and, accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination and repair as well as many aspects of RNA metabolism. This review discusses our current understanding of the structure, function and mechanism of Superfamily 1 helicases.
authors.affiliation: DNA-Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol, UK.
authors.forename: Neville Surain
authors.initials: NS
authors.lastname: Gilhooly
authors.forename: Emma Jane
authors.initials: EJ
authors.lastname: Gwynn
authors.forename: Mark Simon
authors.initials: MS
authors.lastname: Dillingham
mesh_terms: D004265:DNA Helicases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D020365:RNA Helicases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D004265:DNA Helicases; D020365:RNA Helicases