title: Registration of brainstem surfaces in adolescent idiopathic scoliosis using discrete Ricci flow.
abstract: Adolescent Idiopathic Scoliosis (AIS) characterized by the 3D spine deformity affects about 4% schoolchildren worldwide. Several studies have demonstrated the malfunctioning of postural balance, proprioception, and equilibrium control in patients with AIS. Since these functions are closely related to structures in and around the brainstem, the morphometry of the brainstem surface is of utmost importance. In this paper, we propose an effective method to accurately compute the registration between brainstem surfaces. Four consistent features, which describe the global geometry of the brainstem, are automatically extracted to guide the surface registration. Using the discrete Ricci flow method, brainstem surfaces are parameterized conformally onto the quadrilaterally-faced hexahedron, through which the brainstem registration can be obtained. Our registration algorithm can guarantee the exact landmark correspondence between brainstem surfaces. With the obtained registration, a shape energy can be defined to measure the local shape difference between different brainstem surfaces. We have tested our algorithms on 30 real brainstem surfaces extracted from MRIs of 15 normal subjects and 15 AIS patients. Experimental results show the efficacy of the proposed algorithm to register brainstem surfaces, which matches landmark features consistently. The computed registration can be used for the morphometry of brainstems.
authors.affiliation: School of Computer Engineering, Nanyang Technological University, Singapore.
authors.forename: Minqi
authors.initials: M
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.forename: Shi
authors.initials: S
authors.lastname: Lin
authors.forename: Defeng
authors.initials: D
authors.lastname: Wang
authors.forename: Lok Ming
authors.initials: LM
authors.lastname: Lui
mesh_terms: D000293:Adolescent; D000465:Algorithms; D001933:Brain Stem / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012600:Scoliosis / Q000473:pathology*; D012680:Sensitivity and Specificity; D013382:Subtraction Technique