title: FDG-PET in the evaluation of myeloma in 2012.
abstract: Multiple myeloma (MM) is a malignant haematological disease characterised by clonal proliferation of malignant plasma cells in the bone marrow. MM is expressed by diffuse infiltration of the bone marrow, focal bone lesions and extra-medullary lesions. Conventional staging follows the Salmon and Durie classification, which was recently revised (Salmon and Durie plus) to include MRI and FDG-PET examinations. FDG-PET is being evaluated for initial staging and therapeutic monitoring and its place still needs to be validated, particularly in comparison with MRI of the pelvis and spine, the reference examination for diagnosis, which is systematically combined with X-rays of the skeleton. Certain recent data in the literature suggest that FDG-PET provides better staging of the disease at the time of diagnosis than MRI, and that the examination has considerable prognostic value when it normalises after the initial courses of chemotherapy and at the end of treatment. As for the evaluation of lymphomas, the interpretation criteria should be standardised.
authors.affiliation: Nuclear Medicine Department, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France; CRCNA, Inserm UMR 892, Nantes cedex 1, France.
authors.forename: C
authors.initials: C
authors.lastname: Bodet-Milin
authors.affiliation: Nuclear Medicine Department, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
authors.forename: T
authors.initials: T
authors.lastname: Eugène
authors.affiliation: Nuclear Medicine Department, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
authors.forename: C
authors.initials: C
authors.lastname: Bailly
authors.affiliation: Nuclear Medicine Department, ICO-Site Gauducheau, Saint-Herblain, France.
authors.forename: M
authors.initials: M
authors.lastname: Lacombe
authors.affiliation: CRCNA, Inserm UMR 892, Nantes cedex 1, France; Radiology Department, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
authors.forename: E
authors.initials: E
authors.lastname: Frampas
authors.affiliation: Radiology Department, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
authors.forename: B
authors.initials: B
authors.lastname: Dupas
authors.affiliation: Haematology Department, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
authors.forename: P
authors.initials: P
authors.lastname: Moreau
authors.affiliation: Nuclear Medicine Department, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France; CRCNA, Inserm UMR 892, Nantes cedex 1, France; Nuclear Medicine Department, ICO-Site Gauducheau, Saint-Herblain, France. Electronic address: francoise.bodere@chu-nantes.fr.
authors.forename: F
authors.initials: F
authors.lastname: Kraeber-Bodéré
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D009101:Multiple Myeloma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D010954:Plasmacytoma / Q000175:diagnosis / Q000473:pathology; D049268:Positron-Emission Tomography; D012680:Sensitivity and Specificity
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: FDG; Multiple myeloma; PET/CT; Solitary plasmacytoma; Therapeutic evaluation