title: Losing stem cells in the aged skeletal muscle niche.
abstract: Why stem cell numbers decline with age is a major question in regenerative biology and medicine. Skeletal muscle has emerged as a powerful paradigm to address this issue. Recently, genetic and cell marking strategies were used to uncover a new and causal relationship between muscle stem cells and differentiated fibers that constitute their niche and provoke their loss.
authors.affiliation: Stem Cells and Development, Department of Developmental & Stem Cell Biology, CNRS URA 2578, Pasteur Institute, 25 rue du Dr. Roux, 75015, Paris, France. shaht@pasteur.fr
authors.forename: Shahragim
authors.initials: S
authors.lastname: Tajbakhsh
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002453:Cell Cycle; D032342:Muscle Cells / Q000166:cytology*; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology*; D055153:Stem Cell Niche / Q000502:physiology*