title: Theoretical ground for adsorptive therapy of anthracyclines cardiotoxicity.
abstract: Anthracyclines play an important role in treatment of variety types of cancer due to their high effectiveness and broad spectrum of activity. However, a major limitation of their use is the dose-limiting cardiotoxicity. The inability to predict and prevent anthracycline cardiotoxicity is in part due to the fact that the molecular and cellular mechanisms remain controversial and incompletely understood. This review focuses on the biochemical basis of the anthracyclines toxic cardiac effects and pharmacological measures to their treatment and preventing. We describe the theoretical substantiation of the enterosorption abilities for diminishing of cardiac damage.
authors.affiliation: I.Ya. Horbachevsky Ternopil State Medical University, Ternopil 46001, Ukraine. doctor.oksana@rambler.ru
authors.forename: O O
authors.initials: OO
authors.lastname: Shevchuk
authors.forename: E A
authors.initials: EA
authors.lastname: Posokhova
authors.forename: L A
authors.initials: LA
authors.lastname: Sakhno
authors.forename: V G
authors.initials: VG
authors.lastname: Nikolaev
mesh_terms: D000818:Animals; D018943:Anthracyclines / Q000009:adverse effects* / Q000737:chemistry*; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced / Q000628:therapy*; D006801:Humans
chemical_list: D018943:Anthracyclines