title: [Meta-analysis of dapoxetine on demand in the treatment of premature ejaculation].
abstract: OBJECTIVE
  To assess the efficacy of dapoxetine on demand for premature ejaculation and provide evidence for clinical decision-making.
  
  
  METHODS
  We searched PubMed, Embase, BIOSIS Previews, Cochrane Library, CNKI Database and Wanfang Database for literature on dapoxetine on demand for premature ejaculation. We performed meta-analysis on the identified publications and evaluated its therapeutic efficacy based on the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGI), and composite PRO criteria for clinical benefit (CCCB).
  
  
  RESULTS
  Four relevant studies were included involving 6 081 cases of premature ejaculation. Compared with the placebo controls, the patients treated with dapoxetine on demand showed significant improvement in IELT (WMD = 1.39, 95% CI [1.23, 1.55], P < 0.000 01), PGI (OR = 2.59, 95% CI [2.21, 3.04], P < 0. 000 01), and CCCB (OR = 2.59, 95% CI [1.98, 3.39], P < 0.000 01). There were significant differences between the 60 mg and 30 mg dapoxetine groups in IELT (WMD = 0.46, 95% CI [0.19, 0.74], P = 0.001 0) and PGI (OR = 1.32, 95% CI [1.06, 1.64], P = 0.01), but not in CCCB (OR = 1.39, 95% CI [0.90, 2.15], P = 0.13).
  
  
  CONCLUSIONS
  Dapoxetine on demand can prolong IELT and improve PGI and CCCB, either at the dose of 60 mg or 30 mg, and has an even better efficacy in prolonging IELT and improving PGI at 60 mg.
authors.affiliation: Department of Urology, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong 510515, China. luoyhny@163.com
authors.forename: Yi-Hong
authors.initials: YH
authors.lastname: Luo
authors.forename: Qi
authors.initials: Q
authors.lastname: Hou
authors.forename: Shao-Bin
authors.initials: SB
authors.lastname: Zheng
mesh_terms: D001596:Benzylamines / Q000627:therapeutic use*; D004542:Ejaculation; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use*; D061686:Premature Ejaculation / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D001596:Benzylamines; D009281:Naphthalenes; C080598:dapoxetine