title: Fatal hyperammonemic brain injury from valproic Acid exposure.
abstract: BACKGROUND
  Hyperammonemia is known to cause neuronal injury, and can result from valproic acid exposure. Prompt reduction of elevated ammonia levels may prevent permanent neurological injury. We report a case of fatal hyperammonemic brain injury in a woman exposed to valproic acid.
  
  
  METHODS
  A 38-year-old woman with schizoaffective disorder and recent increase in valproic acid dosage presented with somnolence and confusion and rapidly progressed to obtundation. Brain MRI showed diffuse bilateral restricted diffusion in nearly the entire cerebral cortex. She had normal liver function tests but serum ammonia level was severely elevated at 288 μmol/l. Genetic testing showed no mutation in urea cycle enzymes. Despite successful elimination of ammonia with hemodialysis she developed fatal cerebral edema.
  
  
  CONCLUSIONS
  Cerebral edema secondary to hyperammonemia is potentially reversible if recognized early. Ammonia excretion can be facilitated by initiation of hemodialysis and administration of scavenging agents (sodium phenylacetate and sodium benzoate). Severe hyperammonemia can result from valproic acid exposure even in the absence of hepatotoxicity or inborn errors of metabolism. It is important to check serum ammonia in any patient with encephalopathy who has had recent valproic acid exposure.
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass., USA.
authors.forename: Danny
authors.initials: D
authors.lastname: Bega
authors.forename: Henrikas
authors.initials: H
authors.lastname: Vaitkevicius
authors.forename: Torrey A
authors.initials: TA
authors.lastname: Boland
authors.forename: Michael
authors.initials: M
authors.lastname: Murray
authors.forename: Sherry H-Y
authors.initials: SH
authors.lastname: Chou
keywords: Cerebral edema; Hyperammonemia; Valproic acid