title: Control of multiple arthropod vector infestations with subolesin/akirin vaccines.
abstract: Diseases transmitted by arthropod vectors such as mosquitoes, ticks and sand flies greatly impact human and animal health and thus their control is important for the eradication of vector-borne diseases (VBD). Vaccination is an environmentally friendly alternative for vector control that allows control of several VBD by targeting their common vector. Recent results have suggested that subolesin/akirin (SUB/AKR) is good candidate antigens for the control of arthropod vector infestations. Here we describe the comparative effect of vaccination with SUB, AKR and Q38 and Q41 chimeras containing SUB/AKR conserved protective epitopes on tick, mosquitoes and sand flies vector mortality, molting, oviposition and/or fertility. We demonstrated that SUB vaccination had the highest efficacy (E) across all vector species (54-92%), Q41 vaccination had the highest vaccine E in mosquitoes (99%) by reducing female survival and fertility, and Q38 vaccination had the highest effect on reducing mosquito (28%) and sand fly (26%) oviposition. The effect of vaccination on different developmental processes in several important arthropod vectors encourages the development of SUB/AKR universal vaccines for the control of multiple vector infestations and reduction of VBD.
authors.affiliation: Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ronda de Toledo s/n, 13005 Ciudad Real, Spain.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Moreno-Cid
authors.forename: José M
authors.initials: JM
authors.lastname: Pérez de la Lastra
authors.forename: Margarita
authors.initials: M
authors.lastname: Villar
authors.forename: Maribel
authors.initials: M
authors.lastname: Jiménez
authors.forename: Rocío
authors.initials: R
authors.lastname: Pinal
authors.forename: Agustín
authors.initials: A
authors.lastname: Estrada-Peña
authors.forename: Ricardo
authors.initials: R
authors.lastname: Molina
authors.forename: Javier
authors.initials: J
authors.lastname: Lucientes
authors.forename: Christian
authors.initials: C
authors.lastname: Gortázar
authors.forename: José
authors.initials: J
authors.lastname: de la Fuente
mesh_terms: D000818:Animals; D060829:Arthropod Proteins / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D001179:Arthropod Vectors / Q000502:physiology; D009033:Culicidae / Q000502:physiology; D005260:Female; D005298:Fertility; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010058:Oviposition; D011576:Psychodidae / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D017422:Sequence Analysis, DNA; D016019:Survival Analysis; D013984:Tick Infestations / Q000276:immunology / Q000517:prevention & control*; D013987:Ticks / Q000502:physiology; D014611:Vaccination / Q000379:methods*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology
chemical_list: D060829:Arthropod Proteins; D011993:Recombinant Fusion Proteins; D014614:Vaccines, Synthetic