title: [Research advances in CKLF-like MARVEL transmembrane domain containing member 5].
abstract: CKLF-like MARVEL transmembrane domain containing member(CMTM)is a novel generic family firstly reported by Peking University Center for Human Disease Genomics. CMTM5 belongs to this family and has exhibited tumor-inhibiting activities. It can encode proteins approaching to the transmembrane 4 superfamily(TM4SF). CMTM5 is broadly expressed in normal adult and fetal human tissues, but is undetectable or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM5 may inhibit the proliferation, migration, and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear, CMTM5 may be involved in various signaling pathways governing the occurrence and development of tumors. CMTM5 may be a new target in the gene therapies for tumors, while further studies on CMTM5 and its anti-tumor mechanisms are warranted.
authors.affiliation: Department of Urology, Peking University People's Hospital, Beijing, China.
authors.forename: Ye-qing
authors.initials: YQ
authors.lastname: Yuan
authors.forename: Yun-bei
authors.initials: YB
authors.lastname: Xiao
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Liu
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Wang
mesh_terms: D018925:Chemokines / Q000235:genetics / Q000378:metabolism; D006801:Humans; D062792:MARVEL Domain-Containing Proteins / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: C525020:CMTM5 protein, human; D018925:Chemokines; D062792:MARVEL Domain-Containing Proteins; D025521:Tumor Suppressor Proteins