title: Linkage replication for chromosomal region 13q32 in schizophrenia: evidence from a Brazilian pilot study on early onset schizophrenia families.
abstract: We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN® software. We found suggestive evidence for linkage on two chromosomal regions, 13q32 and 11p15.4. A LOD score of 2.71 was observed at 13q32 with a one LOD interval extending from 60.63-92.35 cM. From simulations, this LOD score gave a genome-wide empirical corrected p = 0.33, after accounting for all markers tested. Similarly 11p15.4 showed the same maximum LOD of 2.71 and a narrower one LOD interval of 4-14 cM. Of these, 13q32 has been reported to be linked to schizophrenia by multiple different studies. Thus, our study provides additional supporting evidence for an aetiological role of variants at 13q32 in schizophrenia.
authors.affiliation: Interdisciplinary Lab of Clinical Neurosciences (LiNC), and Schizophrenia Program (PROESQ), Department of Psychiatry, Universidade Federal de Sao Paulo (UNIFESP), São Paulo, Brazil. aryararipe@yahoo.com.br
authors.forename: Ary
authors.initials: A
authors.lastname: Gadelha
authors.forename: Vanessa Kiyomi
authors.initials: VK
authors.lastname: Ota
authors.forename: Jose Paya
authors.initials: JP
authors.lastname: Cano
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Melaragno
authors.forename: Marilia A C
authors.initials: MA
authors.lastname: Smith
authors.forename: Jair
authors.initials: J
authors.lastname: de Jesus Mari
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Bressan
authors.forename: Sintia Iole
authors.initials: SI
authors.lastname: Belangero
authors.forename: Gerome
authors.initials: G
authors.lastname: Breen
mesh_terms: D000293:Adolescent; D001938:Brazil; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D010865:Pilot Projects; D012559:Schizophrenia / Q000235:genetics*; D018709:Statistics, Nonparametric; D055815:Young Adult