title: The potential of carboxypeptidase M as a therapeutic target in cancer.
abstract: BACKGROUND
  In the recent literature, carboxypeptidase M (CPM) emerged as a potential cancer biomarker. CPM modulates receptor signaling of kinins, anaphylatoxins, and chemokines. These CPM substrates affect proliferation, angiogenesis, and apoptosis of cancer cells. What is the evidence that CPM is a drug target for cancer therapy?
  
  
  METHODS
  The literature was searched using PubMed with the search terms "carboxypeptidase M" and/or "chromosome 12q13-15" eventually combined with general terms related to cancer. Information was retrieved from the GEO database and material of gene expression and proteomic studies.
  
  
  CONCLUSIONS
  CPM is a part of the molecular signature of many cancers. There is good evidence that it is useful for the discrimination and stratification of cancer types, possibly in combination with other markers such as EGFR and MDM2. Whether it is also a drug target remains to be determined. Lung, kidney, brain, and the reproductive system contain relatively high levels of CPM, but its functions in those tissues are largely unknown. CPM is expressed on tumor-associated macrophages. To facilitate the investigation of CPM in tumor-associated inflammation and in the other aspects of tumor biology, it is necessary to develop potent and selective CPM inhibitors.
authors.affiliation: University of Antwerp, Pharmaceutical Sciences, Laboratory of Medical Biochemistry, Universiteitsplein 1, Antwerp, B-2610, Belgium.
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Denis
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Lambeir
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D049109:Cell Proliferation; D058851:GPI-Linked Proteins / Q000378:metabolism; D006801:Humans; D008666:Metalloendopeptidases / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology; D009389:Neovascularization, Pathologic
chemical_list: D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; C058479:carboxypeptidase M; D008666:Metalloendopeptidases