title: Clinical value of multiband mucosectomy for the treatment of squamous intraepithelial neoplasia of the esophagus.
abstract: OBJECTIVE
  To evaluate the clinical value of multiband mucosectomy (MBM) for the treatment of squamous intraepithelial neoplasia of the esophagus.
  
  
  METHODS
  A total of 51 lesions located at esophagus from 43 patients were treated with MBM, among which 11 were diagnosed as middle-grade intraepithelial neoplasia, 25 as high-grade intraepithelial neoplasia, and 15 as early esophageal cancer pathologically. Primary end-points were the rate of complete endoscopic resection and the mean operation time; the second end-points were the postoperative local recurrence rate and acute plus early complications. The histopathological results were compared between pre-MBM biopsy and MBM specimens. All patients were followed up endoscopically.
  
  
  RESULTS
  A total of 52 MBM procedures with 180 resections were performed in 43 patients. The complete endoscopic resection was achieved in 92.3% (95% confidence interval [CI] 81.8-96.9%). The sizes of the lesions ranged from 10 × 8 mm to 25 × 23 mm. The mean operation time is 37 ± 5 min. The operative acute bleeding complication was 7.6% (95% CI 3-18.1%); no perforations occurred. Early complications consisted of delayed bleeding (one patient 1.9%; 95% CI 0.3-10.1%) and slight esophageal stenosis (one patient). The histopathological diagnosis of 26 cases (51%) was consistent between biopsy and MBM samples, while 20 lesions exhibited higher grade dysplasia. The local recurrence rate was 6.9% (3/43) at 1 year, 9.3% (4/43) at 2 years, and 9.3% at 2.5 years. No death occurred during follow-up.
  
  
  CONCLUSIONS
  MBM is a safe and effective technique for the treatment of early esophageal cancer and precancerous lesions.
authors.affiliation: Department of Gastroenterology, Tengzhou Central People's Hospital of Jining Medical College, Shandong province, China.
authors.forename: Xi-Feng
authors.initials: XF
authors.lastname: Jin
authors.forename: Qing-Yan
authors.initials: QY
authors.lastname: Sun
authors.forename: Tong-Hai
authors.initials: TH
authors.lastname: Chai
authors.forename: Shu-hui
authors.initials: SH
authors.lastname: Li
authors.forename: Yan-li
authors.initials: YL
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000473:pathology / Q000601:surgery*; D004945:Esophagoscopy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011183:Postoperative Complications; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome