title: Facile sonochemical synthesis of novel pyrazolyne derivates at ambient conditions.
abstract: Claisen-Schmidt condensation reaction of 4-acetamidoacetophenone with aromatic aldehydes under ultrasonic irradiation affords acetylaminochalcones (yields: 71-90%) which also under ultrasonic irradiation and in the presence of sodium acetate and acetic acid aqueous undergo facile and clean cyclocondensation with hydrazine to afford 3-(4-acetamidophenyl)-5-(aryl)-1-H-pyrazolines. The pyrazolines were obtained in good to excellent yields (81-89%), and were characterized by conventional spectral data. The work-up is simple and the results obtained indicate that, unlike classical heating, ultrasonic irradiation results in higher yields, shorter reaction times (1.5-2.3 h) and milder conditions.
authors.affiliation: Grupo de Investigación en Compuestos Heterocíclicos, Programa de Química, Facultad de Ciencias Básicas, Universidad del Atlántico, Km 7 Antigua vía Puerto Colombia, Barranquilla-Atlántico, Colombia. dencypacheco@mail.uniatlantico.edu.co
authors.forename: Dency José
authors.initials: DJ
authors.lastname: Pacheco
authors.forename: Luis
authors.initials: L
authors.lastname: Prent
authors.forename: Jorge
authors.initials: J
authors.lastname: Trilleras
authors.forename: Jairo
authors.initials: J
authors.lastname: Quiroga
mesh_terms: D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013010:Sonication
chemical_list: D011720:Pyrazoles