title: Evolutionary game based control for biological systems with applications in drug delivery.
abstract: Control engineering and analysis of biological systems have become increasingly important for systems and synthetic biology. Unfortunately, no widely accepted control framework is currently available for these systems, especially at the cell and molecular levels. This is partially due to the lack of appropriate mathematical models to describe the unique dynamics of biological systems, and the lack of implementation techniques, such as ultra-fast and ultra-small devices and corresponding control algorithms. This paper proposes a control framework for biological systems subject to dynamics that exhibit adaptive behavior under evolutionary pressures. The control framework was formulated based on evolutionary game based modeling, which integrates both the internal dynamics and the population dynamics. In the proposed control framework, the adaptive behavior was characterized as an internal dynamic, and the external environment was regarded as an external control input. The proposed open-interface control framework can be integrated with additional control algorithms for control of biological systems. To demonstrate the effectiveness of the proposed framework, an optimal control strategy was developed and validated for drug delivery using the pathogen Giardia lamblia as a test case. In principle, the proposed control framework can be applied to any biological system exhibiting adaptive behavior under evolutionary pressures.
authors.affiliation: Department of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996-2210, USA.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
authors.forename: Scott C
authors.initials: SC
authors.lastname: Lenaghan
authors.forename: Mingjun
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000220:Adaptation, Biological / Q000502:physiology; D000465:Algorithms; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology; D005075:Biological Evolution; D058448:Biota; D003198:Computer Simulation; D016503:Drug Delivery Systems / Q000379:methods*; D005716:Game Theory; D016829:Giardia lamblia / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D006801:Humans; D008954:Models, Biological; D011157:Population Dynamics / Q000706:statistics & numerical data; D049490:Systems Biology / Q000379:methods
chemical_list: D000981:Antiprotozoal Agents