title: A severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant.
abstract: A patient with severe capillary leakage syndrome caused by a Puumala hantavirus infection was treated with a single dose of icatibant, a bradykinin receptor antagonist, with a dramatic positive response. We suggest that this drug should be tested in a larger number of patients with severe hantavirus infection.
authors.affiliation: Department of Internal Medicine, Tampere University Hospital, Tampere, Finland. jaakko.antonen@pshp.fi
authors.forename: Jaakko
authors.initials: J
authors.lastname: Antonen
authors.forename: Ilona
authors.initials: I
authors.lastname: Leppänen
authors.forename: Jyrki
authors.initials: J
authors.lastname: Tenhunen
authors.forename: Pertti
authors.initials: P
authors.lastname: Arvola
authors.forename: Satu
authors.initials: S
authors.lastname: Mäkelä
authors.forename: Antti
authors.initials: A
authors.lastname: Vaheri
authors.forename: Jukka
authors.initials: J
authors.lastname: Mustonen
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D065168:Bradykinin Receptor Antagonists; D019559:Capillary Leak Syndrome / Q000188:drug therapy / Q000821:virology; D018778:Hantavirus Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D065168:Bradykinin Receptor Antagonists; C065679:icatibant; D001920:Bradykinin