title: Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions.
abstract: Salvia officinalis L. can be found worldwide and its leaves are commonly used as ingredient in food industry. Sage essential oil is applied in the treatment of a range of diseases and has been shown to possess different biological activities. The objectives of our research were to study the effects of environment on crop, chemical composition and anticancer activity on S. officinalis essential oil. Sage was cultivated at eighteen experimental sites in south-central Italy (Molise) in different growing environments. The essential oils (S1-S18), extracted by hydrodistillation, were analyzed by GC and CG/MS. Results show that the main components were α-thujone, camphor, borneol, γ-muurolene and sclareol for all the samples, but the percentages of these compounds varied depending on environmental factors such as altitude, water availability and pedo-climatic conditions. The growth-inhibitory and proapoptotic effects of the eighteen sage essential oils were evaluated in three human melanoma cell lines, A375, M14, and A2058.
authors.affiliation: Department of Drug Sciences, Section of Biochemistry, University of Catania, V.le A. Doria 6, 95125 Catania, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Russo
authors.forename: Carmen
authors.initials: C
authors.lastname: Formisano
authors.forename: Daniela
authors.initials: D
authors.lastname: Rigano
authors.forename: Felice
authors.initials: F
authors.lastname: Senatore
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Delfine
authors.forename: Venera
authors.initials: V
authors.lastname: Cardile
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosselli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bruno
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002849:Chromatography, Gas; D006801:Humans; D013058:Mass Spectrometry; D009822:Oils, Volatile / Q000032:analysis* / Q000494:pharmacology; D027543:Salvia officinalis / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009822:Oils, Volatile