title: Investigating mechanisms of myopia in mice.
abstract: Genetic and environmental factors have been shown to control visually-guided eye growth and influence myopia development. However, investigations into the intersection of these two factors in controlling refractive development have been limited by the lack of a genetically modifiable animal model. Technological advances have now made it possible to assess refractive state and ocular biometry in the small mouse eye and therefore to exploit the many genetic mouse mutants to investigate mechanisms of visually-guided eye growth. This review considers the benefits and challenges of studying refractive development in mice, compares the results of refractive error and ocular biometry from wild-type strains and genetic models in normal laboratory visual environments or with disrupted visual input, and discusses some of the remaining challenges in interpreting data from the mouse to validate and standardize methods between labs.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA. mpardue@emory.edu
authors.forename: Machelle T
authors.initials: MT
authors.lastname: Pardue
authors.forename: Richard A
authors.initials: RA
authors.lastname: Stone
authors.forename: P Michael
authors.initials: PM
authors.lastname: Iuvone
mesh_terms: D000818:Animals; D058452:Axial Length, Eye / Q000473:pathology; D001699:Biometry / Q000379:methods; D004195:Disease Models, Animal; D005123:Eye / Q000254:growth & development; D051379:Mice; D009216:Myopia / Q000503:physiopathology*; D012029:Refraction, Ocular / Q000502:physiology; D014785:Vision, Ocular
keywords: D; Egr-1; LCI; MRI; Mfrp; OCT; QTL; SD-OCT; WT; axial length; c/d; cycles per degree; diopter; early growth response protein; emmetropia; form deprivation; low coherence interferometer; magnetic resonance imaging; membrane frizzled response protein; mouse; myopia; optical coherence interferometry; quantitative trait locus; refractive development; spectral domain-optical coherence interferometry; wild type