title: Hypothalamic histaminergic and orexinergic modulation on cerebellar and vestibular motor control.
abstract: Somatic-nonsomatic integration is critical for generation and execution of an appropriate and coordinated behavioral response to changes in internal and external environments. However, the underlying neural substrates and mechanisms are still enigmatic. Intriguingly, the central histaminergic and orexinergic systems originating from the hypothalamus, a high autonomic regulatory center, innervate almost the whole brain including various subcortical motor structures, particularly the cerebellum and vestibular nuclei. Here, we suggest that the hypothalamic histaminergic and orexinergic system bridging the nonsomatic center to somatic motor structures may actively modulate the cerebellar and vestibular nuclear neurons and subsequently participate in motor control and somatic-nonsomatic integration.
authors.affiliation: Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing, China.
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.forename: Qian-Xing
authors.initials: QX
authors.lastname: Zhuang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Jing-Ning
authors.initials: JN
authors.lastname: Zhu
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D006632:Histamine / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D009434:Neural Pathways / Q000502:physiology / Q000503:physiopathology; D009474:Neurons / Q000502:physiology*; D009479:Neuropeptides / Q000378:metabolism*; D000068797:Orexins; D014722:Vestibule, Labyrinth / Q000502:physiology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins; D006632:Histamine