title: Role of simvastatin in prevention of vasospasm and improving functional outcome after aneurysmal sub-arachnoid hemorrhage: a prospective, randomized, double-blind, placebo-controlled pilot trial.
abstract: BACKGROUND
  Vasospasm plays a major role in the morbidity and mortality after aneurysmal subarachnoid hemorrhage (aSAH). The preliminary studies suggest that statins protect against cerebral vasospasm.
  
  
  OBJECTIVE
  The aim of the study was to determine the role of simvastatin in preventing clinical vasospasm and improving functional outcome in patients with aSAH.
  
  
  METHODS
  All patients with aSAH admitted within 96 h of ictus were randomized to receive either Simvastatin or placebo - 80 mg/day for 14 days. Thirty eight patients were recruited in the study- 19 received Simvastatin and 19 placebo. All the patients underwent surgical clipping of the aneurysm. The primary outcome of the study was the development of clinical cerebral vasospasm. The secondary outcomes included Glasgow Outcome Score (GOS), Modified Rankin Scale (MRS) and Barthel Index Score (MBI) at follow-up at 1, 3 and 6 months.
  
  
  RESULTS
  16% of the patients in the simvastatin group had high Middle Cerebral Artery velocities (> 160 cm/sec) on transcranial Doppler on one or more than one day during the study duration as compared to 26% of the patients in the placebo group (p = 0.70). Neurological deterioration occurred in 26% and 42% of the patients in simvastatin group versus placebo group, respectively (p = 0.31). There was an improvement in the functional outcome in the simvastatin group at 1, 3 or 6 months in the follow-up; however, this difference was not statistically significant.
  
  
  CONCLUSIONS
  There was benefit of simvastatin in terms of reduction in clinical vasospasm, mortality or improved functional outcome, however, this was not statistically significant.
authors.affiliation: Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: K
authors.initials: K
authors.lastname: Garg
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: S S
authors.initials: SS
authors.lastname: Kale
authors.forename: P S
authors.initials: PS
authors.lastname: Chandra
authors.forename: A
authors.initials: A
authors.lastname: Suri
authors.forename: M M
authors.initials: MM
authors.lastname: Singh
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: M S
authors.initials: MS
authors.lastname: Sharma
authors.forename: R M
authors.initials: RM
authors.lastname: Pandey
authors.forename: B S
authors.initials: BS
authors.lastname: Sharma
authors.forename: A K
authors.initials: AK
authors.lastname: Mahapatra
mesh_terms: D004311:Double-Blind Method; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D019821:Simvastatin / Q000627:therapeutic use*; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000601:surgery*; D016896:Treatment Outcome; D020301:Vasospasm, Intracranial / Q000150:complications / Q000517:prevention & control*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin