title: A digital atlas of the dog brain.
abstract: There is a long history and a growing interest in the canine as a subject of study in neuroscience research and in translational neurology. In the last few years, anatomical and functional magnetic resonance imaging (MRI) studies of awake and anesthetized dogs have been reported. Such efforts can be enhanced by a population atlas of canine brain anatomy to implement group analyses. Here we present a canine brain atlas derived as the diffeomorphic average of a population of fifteen mesaticephalic dogs. The atlas includes: 1) A brain template derived from in-vivo, T1-weighted imaging at 1 mm isotropic resolution at 3 Tesla (with and without the soft tissues of the head); 2) A co-registered, high-resolution (0.33 mm isotropic) template created from imaging of ex-vivo brains at 7 Tesla; 3) A surface representation of the gray matter/white matter boundary of the high-resolution atlas (including labeling of gyral and sulcal features). The properties of the atlas are considered in relation to historical nomenclature and the evolutionary taxonomy of the Canini tribe. The atlas is available for download (https://cfn.upenn.edu/aguirre/wiki/public:data_plosone_2012_datta).
authors.affiliation: Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Ritobrato
authors.initials: R
authors.lastname: Datta
authors.forename: Jongho
authors.initials: J
authors.lastname: Lee
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Duda
authors.forename: Brian B
authors.initials: BB
authors.lastname: Avants
authors.forename: Charles H
authors.initials: CH
authors.lastname: Vite
authors.forename: Ben
authors.initials: B
authors.lastname: Tseng
authors.forename: James C
authors.initials: JC
authors.lastname: Gee
authors.forename: Gustavo D
authors.initials: GD
authors.lastname: Aguirre
authors.forename: Geoffrey K
authors.initials: GK
authors.lastname: Aguirre
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D004285:Dogs; D008279:Magnetic Resonance Imaging