title: Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.
abstract: In recent years, it has become apparent that there exist several roles for respiratory complex II beyond metabolism. These include: (i) succinate signaling, (ii) reactive oxygen species (ROS) generation, (iii) ischemic preconditioning, (iv) various disease states and aging, and (v) a role in the function of the mitochondrial ATP-sensitive K(+) (mKATP) channel. This review will address the involvement of complex II in each of these areas, with a focus on how complex II regulates or may be involved in the assembly of the mKATP. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease.
authors.affiliation: Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Wojtovich
authors.forename: C Owen
authors.initials: CO
authors.lastname: Smith
authors.forename: Cole M
authors.initials: CM
authors.lastname: Haynes
authors.forename: Keith W
authors.initials: KW
authors.lastname: Nehrke
authors.forename: Paul S
authors.initials: PS
authors.lastname: Brookes
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000235:genetics*; D042963:Electron Transport Complex II / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D010829:Physiological Phenomena / Q000235:genetics; D015221:Potassium Channels / Q000235:genetics* / Q000378:metabolism
chemical_list: D015221:Potassium Channels; C117780:mitochondrial K(ATP) channel; C478189:respiratory complex II; D000255:Adenosine Triphosphate; D042963:Electron Transport Complex II