title: An efficient method for sterically demanding Suzuki-Miyaura coupling reactions.
abstract: An efficient method for sterically demanding Suzuki-Miyaura coupling reactions has been developed with two catalysts, Pd/BI-DIME (see scheme) and Pd/phenanthrene-based ligand. The Pd/BI-DIME catalyst facilitates the syntheses of extremely hindered biaryls bearing ortho-isopropyl substituents. The other catalyst is efficient for the synthesis of functionalized tetra-ortho-substituted biaryls at low catalyst loadings.
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PR China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.forename: Chengxi
authors.initials: C
authors.lastname: Li
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
authors.forename: Wenjun
authors.initials: W
authors.lastname: Tang
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; D001896:Boron Compounds; D003432:Cross-Linking Reagents; D010616:Phenanthrenes; D010165:Palladium