title: Methotrexate: underused and ignored?
abstract: For more than a decade, methotrexate has been known to be an effective therapeutic agent in the treatment of steroid-dependent active Crohn's disease. However, international data on medication utilization suggest that this drug is rarely used in clinical practice for an indication of Crohn's disease. This review investigates the potential reasons for the underuse of methotrexate in patients with inflammatory bowel diseases.
authors.affiliation: Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC 27599, USA. hherf @ med.unc.edu
authors.forename: Hans H
authors.initials: HH
authors.lastname: Herfarth
authors.forename: Millie D
authors.initials: MD
authors.lastname: Long
authors.forename: Kim L
authors.initials: KL
authors.lastname: Isaacs
mesh_terms: D001379:Azathioprine / Q000191:economics / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000191:economics; D003424:Crohn Disease / Q000188:drug therapy* / Q000191:economics; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D057240:Patient Preference; D016896:Treatment Outcome
chemical_list: D001379:Azathioprine; D008727:Methotrexate