title: Dissecting the hydrophobic effect on the molecular level: the role of water, enthalpy, and entropy in ligand binding to thermolysin.
authors.affiliation: Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, 35032 Marburg, Germany.
authors.forename: Adam
authors.initials: A
authors.lastname: Biela
authors.forename: Nader N
authors.initials: NN
authors.lastname: Nasief
authors.forename: Michael
authors.initials: M
authors.lastname: Betz
authors.forename: Andreas
authors.initials: A
authors.lastname: Heine
authors.forename: David
authors.initials: D
authors.lastname: Hangauer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Klebe
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D019277:Entropy; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D008024:Ligands; D017434:Protein Structure, Tertiary; D013820:Thermolysin / Q000737:chemistry / Q000378:metabolism*; D014867:Water / Q000737:chemistry*
chemical_list: D008024:Ligands; D014867:Water; D013820:Thermolysin