title: Loss of mismatch repair protein expression in breast carcinoma in patients with Lynch Syndrome: report of two cases.
abstract: Lynch Syndrome, an autosomal dominantly inherited cancer predisposition syndrome is not typically associated with development of breast cancer. We present two cases of loss of mismatch protein expression in breast cancer cases in patients with Lynch Syndrome and discuss the literature surrounding the subject.
authors.affiliation: Department of Clinical Genetics, St Georges University of London, London, UK. abeggs@sgul.ac.uk
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Beggs
authors.forename: George
authors.initials: G
authors.lastname: Kousparos
authors.forename: Shirley V
authors.initials: SV
authors.lastname: Hodgson
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000328:Adult; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics* / Q000601:surgery; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein; C501486:MLH1 protein, human; D009687:Nuclear Proteins; C497172:MSH2 protein, human; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein