title: [Microarchitecture assessment of human trabecular bone: description of methods].
abstract: Trabecular bone microarchitecture changes in relation to mechanical stress, effects of age, osteoporosis and anti-osteoporotic drugs. In vivo, these anomalies can be evaluated using textural parameters on high resolution radiographs and images of DXA. It is possible to extract morphological and topological parameters: apparent on MRI images and 3D with a dedicated device called High resolution peripheral quantitative computed tomography (HR-pQCT) with a resolution close to the size of the trabeculae. In vitro, it is possible to obtain on bone samples a 2D analysis by histomorphometry and a 3D analysis from 10 µm images obtained by synchrotron radiation or conventional micro-CT.
authors.affiliation: Laboratoire de biomécanique et biomatériaux ostéo-articulaires (B2OA), UMR 7052 CNRS, Université Paris Diderot-PRES Sorbonne Paris Cité, 10, avenue de Verdun, 75010 Paris, France. christine.chappard@inserm.fr
authors.forename: Christine
authors.initials: C
authors.lastname: Chappard
mesh_terms: D015502:Absorptiometry, Photon; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000648:ultrastructure*; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D011884:Radius / Q000000981:diagnostic imaging; D013977:Tibia / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods; D055114:X-Ray Microtomography / Q000379:methods