title: Clinical and pathological analysis on traditional Chinese medicine syndromes in children with immunoglobulin A nephropathy.
abstract: OBJECTIVE
  To evaluate the common Traditional Chinese Medicine (TCM) syndromes and analyze their relationship to clinical and pathological manifestations in children with IgA nephropathy.
  
  
  METHODS
  Forty five children diagnosed as having primary IgA nephropathy by renal biopsy for the first time were enrolled in this trial, and their TCM syndromes were evaluated and the distribution of TCM syndromes was observed. All the sick children were growed? according to clinical manifestations and pathological damages, and the differences in TCM syndromes were compared between the groups.
  
  
  RESULTS
  The first 5 TCM symptoms were common cold, hyperhidrosis, red dry throat, dark yellow urine and lassitude. In the acute nephritis group, edema and aching pain in loin and knees were significant (P=0.021 and P=0.000). In the severe pathological damage group, edema was obvious (P= 0.004), and 24 h urinary protein was positively correlated with edema (P=0.015) while negatively with common cold (P=0,007). The score of mesangial cell proliferation was correlated with edema, red dry throat and common cold (P=0.006, 0.013 and 0.029 respectively). The score of segmental pathological change was positively correlated with edema (P=0.039).
  
  
  CONCLUSIONS
  Common cold, hyperhidrosis, red dry throat, dark yellow urine, lassitude and other symptoms of qi deficiency of the spleen and lung mainly seen in children with IgA nephropathy may bear a close relationship to clinical manifestations and pathological damages.
authors.affiliation: Traditional Chinese Medicine Department, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Shi
authors.forename: Nan
authors.initials: N
authors.lastname: Zhou
authors.forename: Chunju
authors.initials: C
authors.lastname: Zhou
authors.forename: Ying
authors.initials: Y
authors.lastname: Shen
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005922:Glomerulonephritis, IGA / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*