title: [Role of CFH and ARMS2 polymorphisms in retinopathy and coronary artery disease in type 1 diabetes].
abstract: BACKGROUND
  Type 1 diabetes is associated with vascular morbidity. The aim of this study was to evaluate the role of polymorphisms rs1410996 CFH and rs10490924 ARMS2 with proliferative diabetic retinopathy and coronary disease in type 1 diabetes patients.
  
  
  METHODS
  We present a retrospective study that analyses the clinical characteristics and the polymorphisms rs1410996 CFH and rs10490924 ARMS2 of 147 type 1 diabetes patients.
  
  
  RESULTS
  The patients who developed proliferative diabetic retinopathy in the first 20 years carried the rs1410996 CFH polymorphism. The overall risk-allele frequency was significantly higher among patients with coronary artery disease than in those without it (75 vs. 53%, p<0.001).
  
  
  CONCLUSIONS
  rs1410996 CFH polymorphism could be associated with both proliferative diabetic retinopathy and coronary artery disease in type 1 diabetes patients. However, rs10490924 ARMS2 does not seem to be associated either with retinopathy or coronary artery disease.
authors.affiliation: Unidad de Fisiología Humana, Facultad de Medicina, Universidad de Navarra, 31008, Pamplona, Spain. ndiez@unav.es
authors.forename: M
authors.initials: M
authors.lastname: Toni
authors.forename: J
authors.initials: J
authors.lastname: Hermida
authors.forename: E
authors.initials: E
authors.lastname: Toledo
authors.forename: M J
authors.initials: MJ
authors.lastname: Goñi
authors.forename: N
authors.initials: N
authors.lastname: Díez Goñi
mesh_terms: D000328:Adult; D017242:Complement Factor H / Q000235:genetics*; D003324:Coronary Artery Disease / Q000209:etiology / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics*; D003925:Diabetic Angiopathies / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D012189:Retrospective Studies
chemical_list: C514392:ARMS2 protein, human; D011506:Proteins; D017242:Complement Factor H