title: 30-normedicagenic acid glycosides from Chenopodium foliosum.
abstract: Two new glycosides of 30-normedicagenic acid, namely 3-O-[beta-D-glucuronopyranosyl methyl ester]-2beta,3beta-dihydroxy-30-noroleane-12,20(29)-diene-23,28-dioic acid 28-O-beta-D-glucopyranosyl ester, and 3-O-beta-D-glucopyranosyl-2beta,3beta-dihydroxy-30-noroleane- 12,20(29)-diene-23,28-dioic acid, together with the known 3-O-beta-glucopyranosyl-2beta,3beta-dihydroxy-30-noroleane-12,20(29)-diene-23 ,28-dioic acid 28-O-beta-glucopyranosyl ester, and 3-O-beta-glucuronopyranosyl-2beta,3beta-dihydroxy-30-noroleane-12,20(29)-diene-23,28-dioic acid 28-O-beta-glucopyranosyl ester were isolated from the aerial parts of Chenopodium foliosum Asch. The structures of the compounds were determined by means of spectroscopic methods (1D and 2D NMR, UV, IR) and HRMS-ESI. The compounds were tested for cytotoxicity on three leukemic cell lines (BV-173, SKW-3, HL-60). In addition, the saponins showed moderate stimulatory effects on interleukin-2 production in PHA/PMA stimulated Jurkat E6.1 cells.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria. pnedialkov@gmail.com
authors.forename: Paraskev T
authors.initials: PT
authors.lastname: Nedialkov
authors.forename: Zlatina
authors.initials: Z
authors.lastname: Kokanova-Nedialkova
authors.forename: Daniel
authors.initials: D
authors.lastname: Bücherl
authors.forename: Georgi
authors.initials: G
authors.lastname: Momekov
authors.forename: Jörg
authors.initials: J
authors.lastname: Heilmann
authors.forename: Stefan
authors.initials: S
authors.lastname: Nikolov
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D027462:Chenopodium / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D019169:Jurkat Cells; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D007376:Interleukin-2; D012503:Saponins; D014315:Triterpenes; C005982:medicagenic acid