title: Helminth mediated modulation of Type 1 diabetes (T1D).
abstract: Type 1 diabetes is increasing dramatically in incidence in the developed world. While there may be several reasons for this, improved sanitation and public health measures have altered our interactions with certain infectious agents such as helminths. There is increasing interest in the use of helminths or their products to alleviate inflammatory or allergic conditions. Using rodent models of diabetes, it has been possible to explore the therapeutic potential of both live infections as well as helminth-derived products on the development of autoimmunity. This review provides an overview of the findings from animal models and additionally explores the potential for translation to the clinic.
authors.affiliation: Department of Pathology, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QP, UK.
authors.forename: Paola
authors.initials: P
authors.lastname: Zaccone
authors.forename: Anne
authors.initials: A
authors.lastname: Cooke
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology* / Q000469:parasitology / Q000628:therapy; D015801:Helminth Proteins / Q000235:genetics / Q000276:immunology; D006376:Helminths / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D006801:Humans; D061147:Therapy with Helminths
chemical_list: D015801:Helminth Proteins