title: Zn-mediated asymmetric allylation of N-tert-butanesulfinyl ketimines: an efficient and practical access to chiral quaternary 3-aminooxindoles.
abstract: Room temperature zinc-mediated diastereoselective allylation or propargylation of isatin-derived N-tert-butanesulfinyl ketimines for synthesis of highly enantiomerically enriched tetrasubstituted 3-aminooxindoles is described.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
authors.forename: Diao
authors.initials: D
authors.lastname: Chen
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Xu
mesh_terms: D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D000078183:Oxindoles; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
chemical_list: D007097:Imines; D007211:Indoles; D009570:Nitriles; D000078183:Oxindoles; C542835:ketimine; C022960:2-oxindole; D015032:Zinc