title: [Psammomatous melanotic schwannoma as indicator of a Carney complex].
abstract: Within a few months a 31-year-old female patient was diagnosed with a psammomatous melanotic schwannoma, an atrial myxoma and microfollicular adenomas in both thyroid lobes. Therefore, sufficient diagnostic criteria of a Carney complex were fulfilled. The Carney complex is an inherited autosomal dominant disorder with highly variable phenotypes, which was initially described by Carney in 1985 as a complex of myxomas, spotty skin pigmentation and endocrine overactivity. Pathologists should consider this differential diagnosis in reports when confronted with a psammomatous melanotic schwannoma.
authors.affiliation: Institut für Pathologie, Universitätsklinikum Freiburg, Freiburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Seidl
authors.forename: G
authors.initials: G
authors.lastname: Zolnhofer
authors.forename: S
authors.initials: S
authors.lastname: Gunser
authors.forename: J
authors.initials: J
authors.lastname: Ennker
authors.forename: W
authors.initials: W
authors.lastname: Schäfer
authors.forename: L
authors.initials: L
authors.lastname: Tietze
mesh_terms: D000236:Adenoma / Q000235:genetics / Q000473:pathology*; D000328:Adult; D056733:Carney Complex / Q000235:genetics / Q000473:pathology*; D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit / Q000235:genetics; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000473:pathology; D006325:Heart Atria / Q000473:pathology; D006338:Heart Neoplasms / Q000235:genetics / Q000473:pathology*; D006801:Humans; D009232:Myxoma / Q000235:genetics / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D009442:Neurilemmoma / Q000235:genetics / Q000473:pathology*; D010641:Phenotype; D015398:Signal Transduction / Q000235:genetics; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology*
chemical_list: D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit