title: Gene expression profile analysis of lymphomas.
abstract: Through the genome-wide characterization of a cell type's transcriptome, gene expression profile analysis provides a potent tool for analyzing the pathogenesis of lymphomas and has had a major impact on the understanding of lymphoid neoplasia. The analysis of gene expression patterns of lymphomas and normal lymphocytes permits (1) the definition of molecular subtypes of lymphoma; (2) the identification of the normal cellular counterpart of a lymphoma subtype; (3) the identification of diagnostic markers and therapeutic targets; and (4) the identification of signaling pathways affected by the oncogenic transformation. This chapter presents an approach to accomplish these goals.
authors.affiliation: Institute for Cancer Genetics, Columbia University, New York, NY, USA.
authors.forename: Katia
authors.initials: K
authors.lastname: Basso
authors.forename: Ulf
authors.initials: U
authors.lastname: Klein
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D057225:Data Mining; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D008223:Lymphoma / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification
chemical_list: D014408:Biomarkers, Tumor; D018076:DNA, Complementary; D012333:RNA, Messenger