title: Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex.
abstract: Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into mitochondrial mRNAs by the RNA editing core complex (RECC). The characterization of constituent subunits of the mitochondrial RNA-binding complex 1 (MRB1) implies that it too is vital to the editing process. The recently elucidated MRB1 architecture will be instrumental in putting functional data from individual subunits into context. Our model depicts two functions for MRB1: mediating multi-round kRNA editing by coordinating the exchange of multiple gRNAs required by RECC to edit lengthy regions of mRNAs, and then linking kRNA editing with other RNA processing events.
authors.affiliation: Institute of Parasitology, Biology Center, Czech Academy of Sciences, Faculty of Science, University of South Bohemia, České Budějovice (Budweis) 370 05, Czech Republic.
authors.forename: Hassan
authors.initials: H
authors.lastname: Hashimi
authors.forename: Sara L
authors.initials: SL
authors.lastname: Zimmer
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Ammerman
authors.forename: Laurie K
authors.initials: LK
authors.lastname: Read
authors.forename: Julius
authors.initials: J
authors.lastname: Lukeš
mesh_terms: D016830:Kinetoplastida / Q000235:genetics* / Q000378:metabolism*; D015800:Protozoan Proteins / Q000378:metabolism*; D017393:RNA Editing; D017394:RNA, Guide, Kinetoplastida / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D016053:RNA, Protozoan / Q000235:genetics* / Q000378:metabolism*; D014346:Trypanosoma brucei brucei / Q000235:genetics / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
chemical_list: D015800:Protozoan Proteins; D012333:RNA, Messenger; D016053:RNA, Protozoan; D014529:Uridine; D017394:RNA, Guide, Kinetoplastida