title: Prevention of diabetes: a strategic approach for individual patients.
abstract: The 'diabetes epidemic' is an important health and socioeconomic problem worldwide. Type 2 diabetes is a chronic disease with gradual deterioration in glucose metabolism which causes multiple systemic complications. Therefore, early intervention in the prediabetic stage is a valuable approach to reduce diabetes development and related complications. Many clinical trials have suggested that lifestyle intervention, including moderate-intensity exercise and diet control, and pharmacologic intervention using metformin, α-glucosidase inhibitors, thiazolidinediones, anti-obesity drugs and incretin mimics, are effective in preventing diabetes development. However, an individualized approach with careful consideration of the patient's risk status and health economics is needed to perform a successful intervention programmes. In this review, we will summarize the known evidence on treatment- and cost-effectiveness of drug and lifestyle treatment. Additionally, we will propose a strategic approach algorithm that is applicable to clinical practice.
authors.affiliation: Department of Endocrinology & Metabolism, Seoul St. Mary's Hospital, The Catholic University of Korea School of Medicine, Seoul, Korea.
authors.forename: Jeong-Ah
authors.initials: JA
authors.lastname: Shin
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Hun-Sung
authors.initials: HS
authors.lastname: Kim
authors.forename: Yoon-Hee
authors.initials: YH
authors.lastname: Choi
authors.forename: Jae-Hyoung
authors.initials: JH
authors.lastname: Cho
authors.forename: Kun-Ho
authors.initials: KH
authors.lastname: Yoon
mesh_terms: D003362:Cost-Benefit Analysis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000191:economics / Q000517:prevention & control*; D015444:Exercise; D006801:Humans; D007004:Hypoglycemic Agents / Q000191:economics / Q000627:therapeutic use*; D008019:Life Style; D011236:Prediabetic State / Q000188:drug therapy* / Q000191:economics; D011322:Primary Prevention
chemical_list: D007004:Hypoglycemic Agents