title: Fasting blood glucose is a novel prognostic indicator for extranodal natural killer/T-cell lymphoma, nasal type.
abstract: BACKGROUND
  Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL) is an aggressive disease with poor prognosis, requiring risk stratification. However, the prognosis of ENKTL is not fully defined and needs supplementation. We hypothesised that fasting blood glucose (FBG) may be a new prognostic factor for ENKTL.
  
  
  METHODS
  We retrospectively analysed 130 patients newly diagnosed with ENKTL.
  
  
  RESULTS
  Both univariate analysis and multivariate analysis revealed that FBG >100 mg dl(-1) was associated with a poor outcome. Patients with FBG >100 mg dl(-1) at diagnosis had more adverse clinical features, achieved lower complete remission rates (P=0.003) and had worse overall survival (P<0.001) and progression-free survival (P<0.001) compared with low-FBG patients. Measurement of FBG was helpful in differentiating between low-risk patients using the International Prognostic Index (IPI) and Prognosis Index for peripheral T-cell lymphoma (PIT) scoring and patients in a different category using the Korean Prognostic Index (KPI) scores with different survival outcomes (P<0.05).
  
  
  CONCLUSIONS
  Our data suggest that measuring FBG levels at diagnosis is a novel, independent predictor of prognosis in ENKTL and helps to distinguish low-risk patients with poor survival, and this holds true in patients considered low-risk by IPI, PIT and KPI.
authors.affiliation: Department of Medical Oncology, Cancer Center, Sun Yat-sen University, 651 Dong Feng RD East, Guangzhou 510060, PR China.
authors.forename: Q
authors.initials: Q
authors.lastname: Cai
authors.forename: X
authors.initials: X
authors.lastname: Luo
authors.forename: Y
authors.initials: Y
authors.lastname: Liang
authors.forename: H
authors.initials: H
authors.lastname: Rao
authors.forename: X
authors.initials: X
authors.lastname: Fang
authors.forename: W
authors.initials: W
authors.lastname: Jiang
authors.forename: T
authors.initials: T
authors.lastname: Lin
authors.forename: T
authors.initials: T
authors.lastname: Lin
authors.forename: H
authors.initials: H
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005215:Fasting; D005260:Female; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000097:blood* / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D001786:Blood Glucose