title: Near-infrared fluorescent detection of glutathione via reaction-promoted assembly of squaraine-analyte adducts.
abstract: The first "off-on" dual-output fluorescent assay based on reaction-promoted self-assembly approach for glutathione recognition in near infrared region over other relative thiols including cysteine and homocysteine was constructed with high selectivity and large Stocks shift (about 220 nm). The fluorescence enhancement is attributed to the intermolecular interaction, which manipulates the squaraine's aggregates and results in FRET for NIR emission. The sensitivity of the sensing ensemble was further improved in buffer solution containing cationic surfactant.
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China. xuyq@nwsuaf.edu.cn
authors.forename: Yongqian
authors.initials: Y
authors.lastname: Xu
authors.forename: Benhao
authors.initials: B
authors.lastname: Li
authors.forename: Pan
authors.initials: P
authors.lastname: Han
authors.forename: Shiguo
authors.initials: S
authors.lastname: Sun
authors.forename: Yi
authors.initials: Y
authors.lastname: Pang
mesh_terms: D003503:Cyclobutanes / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry; D005978:Glutathione / Q000032:analysis* / Q000737:chemistry; D010636:Phenols / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D003503:Cyclobutanes; D005456:Fluorescent Dyes; D010636:Phenols; C480596:squaraine; D005978:Glutathione