title: Dosimetric accuracy of a deterministic radiation transport based (192)Ir brachytherapy treatment planning system. Part III. Comparison to Monte Carlo simulation in voxelized anatomical computational models.
abstract: OBJECTIVE
  To compare TG43-based and Acuros deterministic radiation transport-based calculations of the BrachyVision treatment planning system (TPS) with corresponding Monte Carlo (MC) simulation results in heterogeneous patient geometries, in order to validate Acuros and quantify the accuracy improvement it marks relative to TG43.
  
  
  METHODS
  Dosimetric comparisons in the form of isodose lines, percentage dose difference maps, and dose volume histogram results were performed for two voxelized mathematical models resembling an esophageal and a breast brachytherapy patient, as well as an actual breast brachytherapy patient model. The mathematical models were converted to digital imaging and communications in medicine (DICOM) image series for input to the TPS. The MCNP5 v.1.40 general-purpose simulation code input files for each model were prepared using information derived from the corresponding DICOM RT exports from the TPS.
  
  
  RESULTS
  Comparisons of MC and TG43 results in all models showed significant differences, as reported previously in the literature and expected from the inability of the TG43 based algorithm to account for heterogeneities and model specific scatter conditions. A close agreement was observed between MC and Acuros results in all models except for a limited number of points that lay in the penumbra of perfectly shaped structures in the esophageal model, or at distances very close to the catheters in all models.
  
  
  CONCLUSIONS
  Acuros marks a significant dosimetry improvement relative to TG43. The assessment of the clinical significance of this accuracy improvement requires further work. Mathematical patient equivalent models and models prepared from actual patient CT series are useful complementary tools in the methodology outlined in this series of works for the benchmarking of any advanced dose calculation algorithm beyond TG43.
authors.affiliation: Medical School, University of Athens, Athens, Greece. kzourari@med.uoa.gr
authors.forename: K
authors.initials: K
authors.lastname: Zourari
authors.forename: E
authors.initials: E
authors.lastname: Pantelis
authors.forename: A
authors.initials: A
authors.lastname: Moutsatsos
authors.forename: L
authors.initials: L
authors.lastname: Sakelliou
authors.forename: E
authors.initials: E
authors.lastname: Georgiou
authors.forename: P
authors.initials: P
authors.lastname: Karaiskos
authors.forename: P
authors.initials: P
authors.lastname: Papagiannis
mesh_terms: D000465:Algorithms; D001918:Brachytherapy / Q000379:methods*; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy; D003198:Computer Simulation; D004938:Esophageal Neoplasms / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008953:Models, Anatomic; D009010:Monte Carlo Method; D011874:Radiometry; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*
chemical_list: D007496:Iridium Radioisotopes