title: [Gastric non-Hodgkin lymphoma associated with heavy metal exposures].
abstract: Primary extranodal Non-Hodgkin lymphoma (NHL) is a non epithelial tumours that accounts for 40% of cases of NHL. Spread of nodal lymphomas to the gastrointestinal tract (GIT) is the most common location. Within the GIT is the stomach the most affected organ (60%). We report the case of 52-year- old man , mining company worker for over 10 years, which is derived to the Service of Gastroenterology with history of epigastric pain, nausea, vomiting and weight loss. Upper gastrointestinal endoscopic examination revealed an ulcerated lesion on greater curve of stomach and histopathological examination and subsequent immunohistochemical analysis showed diffuse large B cell gastric NHL. Also, the patient had multiple organ involvement in relation to chronic exposure to heavy metals, which was found in the mineralograma, with the highest concentration of uranium, thallium, arsenic, lead and mercury. The literature has described the association of chronic occupational exposure to uranium and arsenic with NHL presenting gastrointestinal involvement. Therefore, gastric commitment can not be considered as an isolated injury, but rather part of systemic involvement associated with elevated concentrations of metals. Mining is a key driver of income for Peru; however, there are no reports to date of the association of gastrointestinal NHL commitment regarding occupational exposure to heavy metals.
authors.affiliation: Médico Gastroenterólogo del Hospital Nacional Arzobispo Loayza.
authors.forename: Jorge
authors.initials: J
authors.lastname: Garavito Rentería
authors.forename: William Javier
authors.initials: WJ
authors.lastname: Araujo Banchón
authors.forename: María Pía
authors.initials: MP
authors.lastname: Quesada Ríos
authors.forename: Diego
authors.initials: D
authors.lastname: Ponce de León
mesh_terms: D002274:Carcinogens, Environmental / Q000009:adverse effects*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000139:chemically induced / Q000175:diagnosis*; D008297:Male; D019216:Metals, Heavy / Q000009:adverse effects*; D008875:Middle Aged; D008906:Mining; D009784:Occupational Diseases / Q000139:chemically induced / Q000175:diagnosis*; D016273:Occupational Exposure / Q000009:adverse effects*; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000175:diagnosis*
chemical_list: D002274:Carcinogens, Environmental; D019216:Metals, Heavy