title: [Global improvement in agitated depression treated with the alliance therapy of acupuncture and seroxat and the observation of the quality of life].
abstract: OBJECTIVE
  To compare the differences in the efficacy on agitated depression among the alliance therapy of acupuncture and seroxat, the alliance therapy of electroacupuncture and seroxat and the simple application of seroxat.
  
  
  METHODS
  One hundred and two cases were randomized into a medication group, a conventional acupuncture + medication group and an electroacupuncture + medication group, 34 cases in each one. In the medication group, seroxat was prescribed for oral administration, once per day. In the conventional acupuncture + medication group, seroxat was applied in combination with the conventional acupuncture therapy, in which, Baihui (GV 20) and Yintang (EX-HN 3) were taken as the main acupoints. In the electroacupuncture + medication group, seroxat was applied in combination with electroacupuncture, in which, on the basic therapeutic program as the conventional acupuncture + medication group, the electric stimulation was attached to Baihui (GV 20) and Yintang (EX-HN 3). Acupuncture was applied once every two days, the treatment of 6 weeks made one session and one session treatment was required in the research. Before and after treatment, the clinical global impression (CGI) and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) were adopted for the assessment in each group.
  
  
  RESULTS
  (1) CGI comparison: the severity of illness (SI) after treatment was all alleviated significantly for the patients in three groups as compared with that before treatment (all P < 0.001), but the difference was not significant statistically among groups (P > 0.05). The global improvement (GI) was different significantly among three groups (P < 0.05), in which GI in the electroacupuncture + medication group was the best, that in the conventional acupuncture + medication group was taken second place. The total improvement rates were 100.0% (29/29), 96.9% (31/32) and 93.5% (29/31) separately. The difference in the efficacy index (EI) was not significant statistically among three groups (P > 0.05). Concerning to the adverse events, there were 1 case (mild insomnia) in the medication group, 1 case (moderate anorexia) in the conventional acupuncture + medication group and 2 cases (mild insomnia and dry mouth) in the electroacupuncture + medication group. (2) WHOQOL-BREF comparison: compared with those before treatment, all the indices in the electroacupuncture + medication group were increased significantly after treatment (all P < 0.01); except the indices in the physiological field, all the other indices were improved in the conventional acupuncture + medication group after treatment (P < 0.01, P < 0.05); the scores only in the physiological field and social field were higher significantly than those before treatment in the medication group (P < 0.01, P < 0.05). After treatment, the statistically significant difference was displayed only in the psychological field among three groups (P < 0.05), in which, the improvement in the electroacupuncture + medication group was the best, that in the conventional acupuncture + medication group was taken second place and that in the medication group was the worst.
  
  
  CONCLUSIONS
  Either the alliance therapy of acupuncture and medication or the simple oral administration of seroxat improves the overall efficacy and the quality of life in the patients with agitated depression. The efficacy of the alliance therapy of acupuncture and medication is superior to the simple oral administration of seroxat and the efficacy of electroacupuncture is superior to the conventional acupuncture therapy.
authors.affiliation: College of TCM, Southern Medical University, Guangzhou 510515, Guangdong Province, China. 178391100@qq.com
authors.forename: Wei-Rong
authors.initials: WR
authors.lastname: Lin
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.forename: Jun-Qi
authors.initials: JQ
authors.lastname: Chen
authors.forename: Sheng-Xu
authors.initials: SX
authors.lastname: Wang
mesh_terms: D015670:Acupuncture Therapy; D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003863:Depression / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000627:therapeutic use*; D011788:Quality of Life; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D017374:Paroxetine