title: Spectroscopic studies and biological activity of some transition metal complexes of unusual Schiff base.
abstract: Unusual Schiff base ligand, 4-ethanimidoyl-6-[(1E)-N-(2-hydroxy-4-methylphenyl)ethanimidoyl]benzene-1,3-diol, L, was synthesized via catalytic process involving the interaction of some metal ions with a macrocyclic Schiff base (MSB). The transition metal derivatives [ML(H(2)O)(4)](NO(3))(3), M=Cr(III) and Fe(III), [NiL(H(2)O)(4)](NO(3))(2), [ML(H(2)O)(2)](NO(3))(2), M=Zn(II) and Cd(II), [Cl(2)Pd(μ-Cl)(2)PdL], [PtL(Cl)(2)] and [PtL(Cl)(4)] were also synthesized from the corresponding metal species with L. The Schiff bases and complexes were characterized by elemental analysis, mass spectrometry, IR and (1)H NMR spectroscopy. The crystal structure of L was determined by X-ray analysis. The spectroscopic studies revealed a variety of structure arrangements for the complexes. The biological activities of L and metal complexes against the Escherchia coli as Gram-negative bacteria and Staphylococcus aureus as Gram-positive bacteria, and the two fungus Aspergillus flavus and Candida albicans were screened. The cytotoxicity of [PtL(Cl)(2)] complex, a cis-platin analogous, was checked as an antitumor agent on two breast cancer cell lines (MCF7 and T47D) and human liver carcinoma cell line (HepG2).
authors.affiliation: Applied Chemistry Department, Faculty of Applied Science, Taibah University, Almadinah Almunawrah, Saudi Arabia.
authors.forename: Ahmad K
authors.initials: AK
authors.lastname: Abu Al-Nasr
authors.forename: Ramadan M
authors.initials: RM
authors.lastname: Ramadan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D001231:Aspergillus flavus / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D001555:Benzene Derivatives / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008958:Models, Molecular; D009181:Mycoses / Q000188:drug therapy; D012545:Schiff Bases / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D028561:Transition Elements / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001555:Benzene Derivatives; D056831:Coordination Complexes; D012545:Schiff Bases; D028561:Transition Elements