title: Anticoagulant prevention in patients with atrial fibrillation: alternatives to vitamin K antagonists.
abstract: Patients with nonvalvular atrial fibrillation (AF) and risk factors for stroke need anticoagulation to avoid thromboembolic complications. Vitamin K antagonists (VKAs) are an established pharmacological group the use of which is recommended by guidelines. However, VKAs (like warfarin) have major disadvantages, such as a variable dose-effect relationship, drug and food interactions, the need for regular blood testing and dose titration, and, finally, a substantial risk of bleeding. New oral anticoagulants are intended to replace warfarin, being at least as safe and effective, and lacking some of the disadvantages of VKAs. Clinical data for dabigatran, rivaroxaban, apixaban and edoxaban, and other new drugs, are discussed in this article with special focus on their use in nonvalvular AF.
authors.affiliation: Department of Cardiology and Electrotherapy, Second Chair of Cardiology, Medical University of Gdansk, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kozlowski
authors.forename: Szymon
authors.initials: S
authors.lastname: Budrejko
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Raczak
authors.forename: Jacek
authors.initials: J
authors.lastname: Rysz
authors.forename: Maciej
authors.initials: M
authors.lastname: Banach
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy*; D015195:Drug Design; D016903:Drug Monitoring / Q000379:methods; D006470:Hemorrhage / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control; D014812:Vitamin K / Q000037:antagonists & inhibitors; D014859:Warfarin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014812:Vitamin K; D014859:Warfarin