title: Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors.
abstract: There were synthesized new types of ribbon type steroidal dimers derived from three types of steroidal skeletons (cholic acid, etienic acid, estrone) using Cu(I) catalyzed 1, 3-dipolar cycloaddition reaction. Steroid parts of the molecular "ribbons" are linked by heterocyclic moiety, namely by 2,6-bis((1H-1,2,3-triazol-1-yl)-methyl)pyridine. Compounds synthesized possess different cytotoxic and hormone receptor modulating activities.
authors.affiliation: Institute of Chemical Technology, CZ-166 28 Prague, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Jurášek
authors.forename: Petr
authors.initials: P
authors.lastname: Džubák
authors.forename: David
authors.initials: D
authors.lastname: Sedlák
authors.forename: Hana
authors.initials: H
authors.lastname: Dvořáková
authors.forename: Marián
authors.initials: M
authors.lastname: Hajdúch
authors.forename: Petr
authors.initials: P
authors.lastname: Bartůněk
authors.forename: Pavel
authors.initials: P
authors.lastname: Drašar
mesh_terms: D000736:Androstenes / Q000737:chemistry*; D002384:Catalysis; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D019826:Cholic Acid / Q000737:chemistry*; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000494:pharmacology; D004970:Estrone / Q000737:chemistry*; D006727:Hormone Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry; D011987:Receptors, Steroid / Q000037:antagonists & inhibitors / Q000378:metabolism; D013256:Steroids / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000736:Androstenes; D003603:Cytotoxins; D006727:Hormone Antagonists; D011725:Pyridines; D011987:Receptors, Steroid; D013256:Steroids; D004970:Estrone; C004251:etienic acid; D019826:Cholic Acid