title: Synthesis and anti-inflammatory activity of new alkyl-substituted phthalimide 1H-1,2,3-triazole derivatives.
abstract: Four new 1,2,3-triazole phthalimide derivatives with a potent anti-inflammatory activity have been synthesized in the good yields by the 1,3-dipolar cycloaddition reaction from N-(azido-alkyl)phthalimides and terminal alkynes. The anti-inflammatory activity was determined by injecting carrageenan through the plantar tissue of the right hind paw of Swiss white mice to produce inflammation. All the compounds 3a-c and 5a-c exhibited an important anti-inflammatory activity; the best activity was found for the compounds 3b and 5c, which showed to be able to decrease by 69% and 56.2% carrageenan-induced edema in mice. These compounds may also offer a future promise as a new anti-inflammatory agent.
authors.affiliation: Laboratório de Química e Metabolismo de Lipídeos e Lipoproteínas, Departamento de Bioquímica, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego s/n, 50670-420 Recife, PE, Brazil.
authors.forename: Shalom Pôrto de Oliveira
authors.initials: SP
authors.lastname: Assis
authors.forename: Moara Targino
authors.initials: MT
authors.lastname: da Silva
authors.forename: Ronaldo Nascimento
authors.initials: RN
authors.lastname: de Oliveira
authors.forename: Vera Lúcia de Menezes
authors.initials: VL
authors.lastname: Lima
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use; D002351:Carrageenan / Q000633:toxicity; D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000639:trends; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D010797:Phthalimides / Q000138:chemical synthesis* / Q000627:therapeutic use; D014230:Triazoles / Q000138:chemical synthesis* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010797:Phthalimides; D014230:Triazoles; D002351:Carrageenan