title: Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients.
abstract: Analyzing medical records of 979 patients with severe sepsis or septic shock provided some evidence that the use of low-dose aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) was associated with decreased hospital mortality. However, the benefit was abolished when aspirin and NSAIDs were given together.
authors.forename: Maik
authors.initials: M
authors.lastname: Sossdorf
authors.forename: Gordon P
authors.initials: GP
authors.lastname: Otto
authors.forename: Janina
authors.initials: J
authors.lastname: Boettel
authors.forename: Johannes
authors.initials: J
authors.lastname: Winning
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lösche
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D000077144:Clopidogrel; D004305:Dose-Response Relationship, Drug; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy* / Q000401:mortality*; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin