title: [Renal cell carcinoma: A 12-year retrospective study of epidemiologic, therapeutic and follow-up data].
abstract: OBJECTIVE
  To describe the evolution of epidemiology and management of renal cell carcinoma and their impact on overall and progression-free survivals.
  
  
  METHODS
  We reviewed the files of consecutive patients with renal cell carcinoma in our center between January 2000 and December 2011. Patients with confirmed diagnosis on histology who underwent radical nephrectomy, partial nephrectomy or thermoablation were included. Benign tumors were excluded. Epidemiologic and therapeutic data during the period of study were compared. Overall and progression-free survivals divided in three periods were compared by Kaplan-Meier curves.
  
  
  RESULTS
  Four hundred and forty-nine patients were included with a median age of 60 years old [21; 89], and median follow-up of 39 months. Tumor histology was clear cell carcinoma in 75.9% of cases. During the period of study, patients with ASA score upper than 3 increased from 20.4% to 47.8%, tumor size decreased from 58.4mm to 49.5mm and incidental tumor discovery increased from 59.1% to 71.6%. Nephron-sparing surgery increased from 19.7% to 44%. Overall survival and progression-free survival was not different during this period (P=0.071 and P=0.582).
  
  
  CONCLUSIONS
  The increase in early incidental discovery of renal cell carcinoma allowed nephron-sparing surgery in spite of patients with more comorbidities, with stable overall and progression-free survivals in our series.
authors.affiliation: Service d'urologie et transplantation rénale, CHU Grenoble, BP 217, 38043 Grenoble cedex 9, France. varnoux@chu-grenoble.fr
authors.forename: V
authors.initials: V
authors.lastname: Arnoux
authors.forename: J-A
authors.initials: JA
authors.lastname: Long
authors.forename: J
authors.initials: J
authors.lastname: Jund
authors.forename: G
authors.initials: G
authors.lastname: Fiard
authors.forename: N
authors.initials: N
authors.lastname: Terrier
authors.forename: C
authors.initials: C
authors.lastname: Thuillier
authors.forename: B
authors.initials: B
authors.lastname: Boillot
authors.forename: J-J
authors.initials: JJ
authors.lastname: Rambeaud
authors.forename: J-L
authors.initials: JL
authors.lastname: Descotes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D033162:Incidental Findings; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome