title: Hypernatremia and intracranial pressure: more questions than answers.
abstract: The observational literature suggests that hypernatremia is associated with worse outcomes in patients with traumatic brain injury. In a previous issue of Critical Care, Wells and colleagues add to this literature by failing to show an association between hypernatremia and reduced intracranial pressure. However, we must bear in mind many limitations of observational methods before eliminating hyperosmolar therapy from our armamentarium.
authors.forename: Donald E G
authors.initials: DE
authors.lastname: Griesdale
authors.forename: Mypinder S
authors.initials: MS
authors.lastname: Sekhon
authors.forename: William R
authors.initials: WR
authors.lastname: Henderson
mesh_terms: D006259:Craniocerebral Trauma / Q000097:blood*; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D006801:Humans; D006955:Hypernatremia / Q000097:blood*; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D012964:Sodium / Q000097:blood*
chemical_list: D012462:Saline Solution, Hypertonic; D012964:Sodium