title: Usefulness of cardiovascular magnetic resonance imaging for the evaluation of valve opening and closing kinetics in aortic stenosis.
abstract: OBJECTIVE
  The aims of this study were : (i) to determine the feasibility and reproducibility of the measurement of valve kinetic parameters by cardiovascular magnetic resonance (CMR) and (ii) to examine the association between these parameters and markers of a poor prognosis in patients with aortic stenosis (AS).
  
  
  RESULTS
  Eight healthy control subjects and 71 patients with AS (0.60 cm(2) ≤ EOA ≤ 1.90 cm(2)) underwent transthoracic echocardiography (TTE) and CMR. The valve opening slope (OS) and closing slope (CS) were calculated from instantaneous effective orifice area (EOA) curves obtained by CMR. Intra- and inter-observer variability were 4.8 ± 3.9 and 5.0 ± 4.1%, respectively, for OS, 3.8 ± 2.9 and 4.0 ± 3.1% for CS. OS was significantly related to the plasma level of NT-pro-brain natriuretic peptide (BNP) (r = -0.36, P = 0.002), whereas the EOA or gradient were not.
  
  
  CONCLUSIONS
  This study demonstrates the excellent feasibility and reproducibility of CMR for the measurement of valve kinetic parameters in patients with AS. Larger studies are needed to confirm the incremental prognostic value of these new CMR parameters of aortic valve kinetics in patients with severe AS.
authors.affiliation: Québec Heart and Lung Institute, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, 2725 Chemin Sainte-Foy, Quebec, Canada G1V-4G5.
authors.forename: Julio
authors.initials: J
authors.lastname: Garcia
authors.forename: Philippe
authors.initials: P
authors.lastname: Pibarot
authors.forename: Romain
authors.initials: R
authors.lastname: Capoulade
authors.forename: Florent
authors.initials: F
authors.lastname: Le Ven
authors.forename: Lyes
authors.initials: L
authors.lastname: Kadem
authors.forename: Eric
authors.initials: E
authors.lastname: Larose
mesh_terms: D000328:Adult; D000368:Aged; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D016022:Case-Control Studies; D004452:Echocardiography; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results
keywords: Aortic stenosis; Aortic valve; Cardiovascular magnetic resonance; Echocardiography; Valve kinetics