title: Catalytic enantioselective cyclization and C3-fluorination of polyenes.
abstract: (Xylyl-phanephos)Pt(2+) in combination with XeF(2) mediates the consecutive diastereoselective cation-olefin cyclization/fluorination of polyene substrates. Isolated yields were typically in the 60-69% range while enantioselectivities reached as high as 87%. The data are consistent with a stereoretentive fluorination of a P(2)Pt-alkyl cation intermediate.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, CB # 3290, Chapel Hill, North Carolina 27599, USA.
authors.forename: Nikki A
authors.initials: NA
authors.lastname: Cochrane
authors.forename: Ha
authors.initials: H
authors.lastname: Nguyen
authors.forename: Michel R
authors.initials: MR
authors.lastname: Gagne
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D054879:Halogenation; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D011090:Polyenes