title: Strain-based regional nonlinear cardiac material properties estimation from medical images.
abstract: Model personalization is essential for model-based surgical planning and treatment assessment. As alteration in material elasticity is a fundamental cause to various cardiac pathologies, estimation of material properties is important to model personalization. Although the myocardium is heterogeneous, hyperelastic, and orthotropic, existing image-based estimation frameworks treat the tissue as either heterogeneous but linear, or hyperelastic but homogeneous. In view of these, we present a physiology-based framework for estimating regional, hyperelastic, and orthotropic material properties. A cardiac physiological model is adopted to describe the macroscopic cardiac physiology. By using a strain-based objective function which properly reflects the change of material constants, the regional material properties of a hyperelastic and orthotropic constitutive law are estimated using derivative-free optimization. Experiments were performed on synthetic and real data to show the characteristics of the framework.
authors.affiliation: Computational Biomedicine Laboratory, Rochester Institute of Technology, Rochester, USA. chun.lok.wong@rit.edu
authors.forename: Ken C L
authors.initials: KC
authors.lastname: Wong
authors.forename: Jatin
authors.initials: J
authors.lastname: Relan
authors.forename: Linwei
authors.initials: L
authors.lastname: Wang
authors.forename: Maxime
authors.initials: M
authors.lastname: Sermesant
authors.forename: Hervé
authors.initials: H
authors.lastname: Delingette
authors.forename: Nicholas
authors.initials: N
authors.lastname: Ayache
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Shi
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena; D003198:Computer Simulation; D003952:Diagnostic Imaging / Q000379:methods; D006321:Heart / Q000502:physiology; D006331:Heart Diseases / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008953:Models, Anatomic; D015233:Models, Statistical; D009206:Myocardium / Q000473:pathology*; D011312:Pressure; D015203:Reproducibility of Results; D012984:Software; D013314:Stress, Mechanical; D013599:Systole