title: [Aryl hydrocarbon receptor interacting protein gene and familial isolated pituitary adenomas].
abstract: Familial isolated pituitary adenoma (FIPA) is an autosomal dominant disease, characterized by low penetrance, early-onset disease, more invasive tumor growth, as well as somatotroph and lactotroph adenomas in most cases. It has been indicated that the aryl hydrocarbon receptor interacting protein (AIP) gene is a tumor suppressor gene. Many heterozygous mutations have been discovered in AIP in about 20% of FIPA families. However, the exact molecular mechanism by which its disfunction promotes tumorigenesis of pituitary is unclear.
authors.affiliation: Department of Neurosurgery, PUMC Hospital, CAMS and PUMC, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Cai
authors.forename: Yi-dan
authors.initials: YD
authors.lastname: Zhang
authors.forename: Cong-xin
authors.initials: CX
authors.lastname: Dai
authors.forename: Xiao-hai
authors.initials: XH
authors.lastname: Liu
authors.forename: Ya-kun
authors.initials: YK
authors.lastname: Yang
authors.forename: Yong
authors.initials: Y
authors.lastname: Yao
authors.forename: Ren-zhi
authors.initials: RZ
authors.lastname: Wang
mesh_terms: D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D009154:Mutation; D010911:Pituitary Neoplasms / Q000235:genetics*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C103265:aryl hydrocarbon receptor-interacting protein