title: Thrombolysis for stroke caused by infective endocarditis: an illustrative case and review of the literature.
abstract: Infective endocarditis represents a classical contra-indication to thrombolysis for acute ischemic stroke due to a potential increased risk of intracranial hemorrhage. However, some case reports have suggested safety and potential efficacy of intravenous or intra-arterial thrombolysis in stroke related to infective endocarditis. We present a case of ischemic stroke related to infective endocarditis who was treated with intravenous tissue plasminogen activator within the first 3 h of symptoms onset and subsequently developed symptomatic multifocal intracerebral hemorrhages, and summarize currently available data on this issue.
authors.affiliation: Stroke Unit, Neurology Department, Neurological Hospital, Lyon, 59, boulevard Pinel, 69677 Bron Cedex, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Ong
authors.forename: Laura
authors.initials: L
authors.lastname: Mechtouff
authors.forename: Emilien
authors.initials: E
authors.lastname: Bernard
authors.forename: Tae-Hee
authors.initials: TH
authors.lastname: Cho
authors.forename: Lansana Laho
authors.initials: LL
authors.lastname: Diallo
authors.forename: Norbert
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: Laurent
authors.initials: L
authors.lastname: Derex
mesh_terms: D000368:Aged; D000818:Animals; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000209:etiology; D059345:Cerebral Small Vessel Diseases; D004697:Endocarditis, Bacterial / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020521:Stroke / Q000150:complications / Q000209:etiology* / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects*