title: Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones.
abstract: A series of novel pyrazole integrated benzophenones (9a-j) have been designed, synthesized from 1-methyl-5-(2,4,6-trimethoxy-phenyl)-1H-pyrazole 6. The structures of the regioisomers 6 and 7 were determined by 2D (1)H-(1)H COSY, (1)H-(13)C HSQC and (1)H-(13)C HMBC experiments. The newly synthesized compounds (9a-j) were evaluated for in vivo anti-inflammatory activity by carrageenan paw edema in rats and in vitro COX-1/COX-2 inhibition and antioxidant potential. Among the synthesized compounds, compounds 9b, 9d and 9f, were found to be active anti-inflammatory agents in addition to having potent antioxidant activity.
authors.affiliation: Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, Maharashtra, India. bandgar_bp@yahoo.com
authors.forename: Babasaheb P
authors.initials: BP
authors.lastname: Bandgar
authors.forename: Hemant V
authors.initials: HV
authors.lastname: Chavan
authors.forename: Laxman K
authors.initials: LK
authors.lastname: Adsul
authors.forename: Vishnu N
authors.initials: VN
authors.lastname: Thakare
authors.forename: Sadanand N
authors.initials: SN
authors.lastname: Shringare
authors.forename: Rafik
authors.initials: R
authors.lastname: Shaikh
authors.forename: Rajesh N
authors.initials: RN
authors.lastname: Gacche
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001577:Benzophenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D015195:Drug Design; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001577:Benzophenones; D004791:Enzyme Inhibitors; D011720:Pyrazoles; C031280:pyrazole