title: Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung.
abstract: BACKGROUND
  Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patients. However, such information is still lacking in some developing countries.
  
  
  METHODS
  We investigated the frequency of EGFR mutations among Bangladeshi patients with adenocarcinoma of the lung. Fine-needle aspiration tissue samples were collected from 61 Bangladeshi patients. Polymerase chain reaction-single-strand conformation polymorphism was performed on extracted DNA for mutational analysis of EGFR exons 19 and 21.
  
  
  RESULTS
  EGFR mutations were found in 14 of 61 (23.0 %) Bangladeshi patients. There was no significant difference in EGFR mutation rate with regard to patient's age, sex, smoking history, clinical stage of lung cancer, subtypes of adenocarcinoma, and tumor differentiation.
  
  
  CONCLUSIONS
  The present study revealed that the EGFR mutation rate in Bangladeshi patients with adenocarcinoma of the lung was higher than in African-American, Arabian, and white Caucasian patients, and was lower than in East Asia.
authors.affiliation: Department of Thoracic Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
authors.forename: Shakibur
authors.initials: S
authors.lastname: Rahman
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kondo
authors.forename: Kazue
authors.initials: K
authors.lastname: Yoneda
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Takuwa
authors.forename: Masaki
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Hayato
authors.initials: H
authors.lastname: Orui
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Okumura
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Tanaka
authors.forename: Kanako
authors.initials: K
authors.lastname: Kumamoto
authors.forename: Mohammad Golam
authors.initials: MG
authors.lastname: Mostafa
authors.forename: Golam Mohiuddin Akbar
authors.initials: GM
authors.lastname: Chowdhury
authors.forename: Akramul
authors.initials: A
authors.lastname: Haque
authors.forename: Seiki
authors.initials: S
authors.lastname: Hasegawa
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001459:Bangladesh; D044963:Biopsy, Fine-Needle; D004252:DNA Mutational Analysis; D066246:ErbB Receptors / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D012907:Smoking
chemical_list: D066246:ErbB Receptors