title: Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency.
abstract: BACKGROUND
  Ascaris lumbricoides-infected patients present lower prevalence of severe atopic dermatitis.
  
  
  METHODS
  Peripheral blood of infected children with atopic dermatitis was assessed by flow cytometry of the frequency of Th1 and Th2 cells through the expression of CXCR3 and CCR4 chemokine receptors, respectively.
  
  
  RESULTS
  Helminth-free patients with atopic dermatitis presented a high frequency of CCR4+Th2 cells. Parasitized patients with atopic dermatitis showed a lower frequency of CXCR3+Th1 cells compared to infected individuals only.
  
  
  CONCLUSIONS
  Ascariasis modifies the blood traffic of Th2 cells in atopic dermatitis patients, while the allergic disease down-regulates the traffic of Th1 cells in parasitized patients.
authors.affiliation: Universidade Federal de Campina Grande, PB.
authors.forename: Maria Teresa Nascimento
authors.initials: MT
authors.lastname: Silva
authors.forename: Vlaudia Assis
authors.initials: VA
authors.lastname: Costa
authors.forename: Teobaldo Gonzaga Realço
authors.initials: TG
authors.lastname: Pereira
authors.forename: Iana Rafaela Fernandes
authors.initials: IR
authors.lastname: Sales
authors.forename: Silvana Ferreira da
authors.initials: SF
authors.lastname: Silva
authors.forename: Maria Amélia Vieira
authors.initials: MA
authors.lastname: Maciel
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Malagueño
authors.forename: Valdênia Maria Oliveira
authors.initials: VM
authors.lastname: Souza
mesh_terms: D000293:Adolescent; D000818:Animals; D001196:Ascariasis / Q000150:complications / Q000276:immunology*; D017164:Ascaris lumbricoides / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications / Q000276:immunology*; D005243:Feces / Q000469:parasitology; D005434:Flow Cytometry; D006801:Humans; D054398:Receptors, CCR4 / Q000276:immunology*; D054367:Receptors, CXCR3 / Q000276:immunology*; D012720:Severity of Illness Index; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D054398:Receptors, CCR4; D054367:Receptors, CXCR3