title: Physiological functions of protein kinase D in vivo.
abstract: The cellular functions of the serine/threonine protein kinase D (PKD) have been extensively studied within the last decade and distinct roles such as fission of vesicles at the Golgi compartment, coordination of cell migration and invasion, and regulation of gene transcription have been correlated with this kinase family. Here, we highlight the current state of in vivo studies on PKD function with a focus on animal models and discuss the molecular basis of the observed phenotypic characteristics associated with this kinase family.
authors.affiliation: Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, Stuttgart, Germany.
authors.forename: Kornelia
authors.initials: K
authors.lastname: Ellwanger
authors.forename: Angelika
authors.initials: A
authors.lastname: Hausser
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D030801:Animals, Genetically Modified; D020134:Catalytic Domain; D048788:Growth and Development; D006801:Humans; D007527:Isoenzymes / Q000502:physiology; D009928:Organ Specificity; D010766:Phosphorylation; D011493:Protein Kinase C / Q000737:chemistry / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
chemical_list: D007527:Isoenzymes; C089212:protein kinase D; D011493:Protein Kinase C