title: A highly enantioselective Darzens reaction between diazoacetamides and aldehydes catalyzed by a (+)-pinanediol-Ti(O(i)Pr)(4) system.
abstract: A highly efficient enantioselective Darzens reaction of aldehydes with diazoacetamides catalyzed by a (+)-pinanediol-Ti(O(i)Pr)(4) system has been developed. The cis-glycidic amides were obtained in high yields and with moderate to excellent enantioselectivity (up to 99%).
authors.affiliation: School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Daming
authors.initials: D
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Guangyang
authors.initials: G
authors.lastname: Xu
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Sun
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D001880:Boranes / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
chemical_list: D000081:Acetamides; D000447:Aldehydes; D001391:Azo Compounds; D001880:Boranes; D009942:Organometallic Compounds; C119165:2,3-pinanediol; D014025:Titanium