title: Tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein.
abstract: A widely used reducing agent tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein. This discovery clarifies the reactivity of cisplatin towards Sp1 zinc finger protein and implies that the reactions of platinum drugs could be largely influenced by small molecules with a strong trans effect.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui, China.
authors.forename: Siming
authors.initials: S
authors.lastname: Chen
authors.forename: Huan
authors.initials: H
authors.lastname: Jiang
authors.forename: Kaiju
authors.initials: K
authors.lastname: Wei
authors.forename: Yangzhong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D002945:Cisplatin / Q000737:chemistry*; D007536:Isomerism; D010084:Oxidation-Reduction; D010720:Phosphines / Q000737:chemistry*; D016329:Sp1 Transcription Factor / Q000737:chemistry* / Q000378:metabolism
chemical_list: D010720:Phosphines; D016329:Sp1 Transcription Factor; C044646:phosphine; D002945:Cisplatin