title: Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects.
abstract: OBJECTIVE
  To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital.
  
  
  METHODS
  The SNP rs7903146 of TCF7L2 was genotyped by allele-specific PCR in 113 patients with known T2D and in 139 non-diabetic controls in Brasilia, Brazil.
  
  
  RESULTS
  We found that the T allele of the SNP rs7903146 of TCF7L2 was significantly associated with T2D risk (odds ratio of 3.92 for genotype TT in the recessive genetic model, p = 0.004 and 1.5 for T allele, p = 0.032).
  
  
  CONCLUSIONS
  These results reinforce previous findings on the consistent association of this genetic factor and the risk of T2D in populations of diverse ethnic backgrounds.
authors.affiliation: Instituto e Laboratório Sabin de Análises Clínicas, Unidade de Biologia Molecular, Brasília, DF, Brazil. gbarra@gmail.com
authors.forename: Gustavo Barcelos
authors.initials: GB
authors.lastname: Barra
authors.forename: Ludmila Alves Sanches
authors.initials: LA
authors.lastname: Dutra
authors.forename: Sílvia Conde
authors.initials: SC
authors.lastname: Watanabe
authors.forename: Patrícia Godoy Garcia
authors.initials: PG
authors.lastname: Costa
authors.forename: Patrícia Sales Marques da
authors.initials: PS
authors.lastname: Cruz
authors.forename: Monalisa Ferreira
authors.initials: MF
authors.lastname: Azevedo
authors.forename: Angélica Amorim
authors.initials: AA
authors.lastname: Amato
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*
chemical_list: D058118:Transcription Factor 7-Like 2 Protein