title: Glycofullerenes inhibit viral infection.
abstract: Water-soluble glycofullerenes based on a hexakis-adduct of [60]fullerene with an octahedral addition pattern are very attractive compounds providing a spherical presentation of carbohydrates. These tools have been recently described and they have been used to interact with lectins in a multivalent manner. Here, we present the use of these glycofullerenes, including new members with 36 mannoses, as compounds able to inhibit a DC-SIGN-dependent cell infection by pseudotyped viral particles. The results obtained in these experiments demonstrate for the first time that these glycoconjugates are adequate to inhibit efficiently an infection process, and therefore, they can be considered as very promising and interesting tools to interfere in biological events where lectins such as DC-SIGN are involved.
authors.affiliation: Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC-Universidad de Sevilla, Av. Américo Vespucio 49, Seville, Spain.
authors.forename: Joanna
authors.initials: J
authors.lastname: Luczkowiak
authors.forename: Antonio
authors.initials: A
authors.lastname: Muñoz
authors.forename: Macarena
authors.initials: M
authors.lastname: Sánchez-Navarro
authors.forename: Renato
authors.initials: R
authors.lastname: Ribeiro-Viana
authors.forename: Anthony
authors.initials: A
authors.lastname: Ginieis
authors.forename: Beatriz M
authors.initials: BM
authors.lastname: Illescas
authors.forename: Nazario
authors.initials: N
authors.lastname: Martín
authors.forename: Rafael
authors.initials: R
authors.lastname: Delgado
authors.forename: Javier
authors.initials: J
authors.lastname: Rojo
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D002241:Carbohydrates / Q000737:chemistry; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000378:metabolism*; D045744:Cell Line, Tumor; D029043:Ebolavirus / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology*; D006001:Glycoconjugates; D057809:HEK293 Cells; D006801:Humans; D019169:Jurkat Cells; D037102:Lectins; D037181:Lectins, C-Type / Q000737:chemistry / Q000378:metabolism*; D008358:Mannose / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*; D014771:Virion / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D000998:Antiviral Agents; D002241:Carbohydrates; D015815:Cell Adhesion Molecules; D037741:Fullerenes; D006001:Glycoconjugates; D037102:Lectins; D037181:Lectins, C-Type; D008358:Mannose; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin