title: Nutrient restriction and radiation therapy for cancer treatment: when less is more.
abstract: Calorie restriction (CR), or a diet modification aiming to reduce the total intake of calories by 20%-40%, has been shown to increase longevity across multiple species. Recently, there has been growing interest in investigating the potential role of CR as a treatment intervention for age-related diseases, such as cancer, because an increasing body of literature has demonstrated a metabolic component to both carcinogenesis and tumor progression. In fact, many of the molecular pathways that are altered with CR are also known to be altered in cancer. Therefore, manipulation of these pathways using CR can render cancer cells, and most notably breast cancer cells, more susceptible to standard cytotoxic treatment with radiation and chemotherapy. In this review article we demonstrate the laboratory and clinical evidence that exists for CR and show compelling evidence through the molecular pathways CR induces about how it may be used as a treatment in tandem with radiation therapy to improve our rates of disease control.
authors.affiliation: Department of Radiation Oncology, Thomas Jefferson University, Kimmel Cancer Center, Bodine Center for Cancer Treatment, 111 S. 11th Street, G-301G, Philadelphia, Pennsylvania 19107, USA.
authors.forename: Colin E
authors.initials: CE
authors.lastname: Champ
authors.forename: Renato
authors.initials: R
authors.lastname: Baserga
authors.forename: Mark V
authors.initials: MV
authors.lastname: Mishra
authors.forename: Lianjin
authors.initials: L
authors.lastname: Jin
authors.forename: Federica
authors.initials: F
authors.lastname: Sotgia
authors.forename: Michael P
authors.initials: MP
authors.lastname: Lisanti
authors.forename: Richard G
authors.initials: RG
authors.lastname: Pestell
authors.forename: Adam P
authors.initials: AP
authors.lastname: Dicker
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Simone
mesh_terms: D031204:Caloric Restriction / Q000379:methods*; D002986:Clinical Trials as Topic; D004435:Eating / Q000502:physiology; D002149:Energy Intake / Q000502:physiology; D006801:Humans; D008136:Longevity / Q000502:physiology; D053858:Metabolic Networks and Pathways / Q000235:genetics / Q000502:physiology; D009369:Neoplasms / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology / Q000532:radiotherapy*