title: Composition and evaluation of the anti-inflammatory and anticancer activities of the essential oil from Annona sylvatica A. St.-Hil.
abstract: The essential oil from the leaves of Annona sylvatica (EOAS) was extracted by hydrodistillation, and the analysis was performed by gas chromatography-mass spectrometry. The main compounds identified in the EOAS were sesquiterpenes, such as hinesol, z-caryophyllene, β-maaliene, γ-gurjunene, silphiperfol-5-en-3-ol, ledol, cubecol-1-epi, and muurola-3,5-diene. Oral administration of the EOAS (20 and 200 mg/kg) and subcutaneous injection of dexamethasone (0.5 mg/kg, reference drug) significantly inhibited carrageenan- and complete Freund's adjuvant-induced mouse paw edema. The anticancer activity the EOAS showed growth inhibitory activity on all cell lines when administered in a high concentration. The EOAS inhibited the growth of human cancer cell lines with GI(50) values in the range of 36.04-45.37 μg/mL on all of the cell lines tested. This work describes for the first time the anti-inflammatory and anticancer effects of the essential oil of A. sylvatica and its composition. Considering that drugs currently available for the treatment of inflammatory and cancer conditions show undesirable side-effects, the present results may have clinical relevance and open new possibilities for the development of novel anti-inflammatory and anticancer drugs.
authors.affiliation: Facultie of Agricultural Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil. aneliseformagio@ufgd.edu.br
authors.forename: Anelise S N
authors.initials: AS
authors.lastname: Formagio
authors.forename: Maria do Carmo
authors.initials: Mdo C
authors.lastname: Vieira
authors.forename: Luiz A C
authors.initials: LA
authors.lastname: Dos Santos
authors.forename: Claúdia A L
authors.initials: CA
authors.lastname: Cardoso
authors.forename: Mary Anny
authors.initials: MA
authors.lastname: Foglio
authors.forename: João Ernesto
authors.initials: JE
authors.lastname: de Carvalho
authors.forename: Magaiver
authors.initials: M
authors.lastname: Andrade-Silva
authors.forename: Cândida A L
authors.initials: CA
authors.lastname: Kassuya
mesh_terms: D000818:Animals; D031041:Annona / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004487:Edema / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D009822:Oils, Volatile / Q000008:administration & dosage / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D009822:Oils, Volatile; D010936:Plant Extracts; D012717:Sesquiterpenes