title: [Expression of MICA/B protein in esophageal cancer and its clinical significance].
abstract: OBJECTIVE
  To explore the expression of MICA/B in human esophageal cancer, and to analyze its correlation with clinicopathological features.
  
  
  METHODS
  The expression of MICA/B in 40 cases of esophagus carcinoma and corresponding normal esophageal mucosa tissues were examined by immunohistochemistry.
  
  
  RESULTS
  The positive rate of expression of MICA/B protein in the esophageal carcinoma was 75.0% (30/40), and that in the corresponding normal esophageal mucosa was 0 (0/40). Up-regulation of MICA/B expression was found in the esophageal carcinomas. The expression of MICA/B was related with histological grade of the esophageal carcinoma (P = 0.012).
  
  
  CONCLUSIONS
  MICA/B protein plays an important role in the esophageal carcinogenesis, and my become a useful molecular marker for the diagnosis of esophageal carcinoma.
authors.affiliation: Department of Oncology, The People's Hospital of Zhengzhou, Zhengzhou 450003, China. mjzhuan@163.com
authors.forename: Jia-zhuan
authors.initials: JZ
authors.lastname: Mei
authors.forename: Ji-zhi
authors.initials: JZ
authors.lastname: Zhao
authors.forename: Guang-ying
authors.initials: GY
authors.lastname: Yang
authors.forename: Fang-fang
authors.initials: FF
authors.lastname: Gao
authors.forename: Gui-ju
authors.initials: GJ
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; C098080:MICB antigen