title: Recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index.
abstract: Astroblastoma is a rare primary glial tumor of children and young adults. Radiologically astroblastoma presents as a large well-circumscribed supratentorial, solid-cystic heterogeneous mass. Histology shows perivascular pseudorosettes with hyalinization. Only a single case has been reported with signet-ring-like cell morphology. Signet-ring morphology in primary central nervous system tumors is exceedingly rare. Complete surgical resection is the recommended treatment. Prognosis of astroblastoma depends on the extent of resection and histology. The proliferative index may be a useful tool to define prognosis. We present a case of 10-year-old girl having recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index.
authors.affiliation: Department of Pathology, P.D.U. Government Medical College and Hospital, Rajkot, Gujrat, India. eagleeyenasit@gmail.com
authors.forename: Jitendra Gordhanbhai
authors.initials: JG
authors.lastname: Nasit
authors.forename: Priti
authors.initials: P
authors.lastname: Trivedi
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D049109:Cell Proliferation; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008940:Mitotic Index; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D018302:Neoplasms, Neuroepithelial / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor