title: TGFβ1, an epidermal controller of skin dendritic cell homeostasis.
abstract: Transforming growth factor-β1 (TGFβ1) is generally regarded as an anti-inflammatory cytokine. However, previous studies suggest that TGFβ1 can promote immune responses under certain conditions. In this issue, Mohammed et al. report that epidermal keratinocyte-derived TGFβ1 alone can alter homeostasis of multiple cutaneous dendritic cell (DC) subsets, which may enhance skin inflammation. These findings may provide a better understanding of the pathogenesis of inflammatory skin disorders such as psoriasis, although how keratinocyte-derived TGFβ1 regulates cutaneous DCs under physiological and inflammatory conditions should be further addressed.
authors.affiliation: Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kitoh
authors.forename: Takashi
authors.initials: T
authors.lastname: Nomura
authors.forename: Kenji
authors.initials: K
authors.lastname: Kabashima
mesh_terms: D000818:Animals; D003877:Dermatitis, Contact / Q000378:metabolism*; D005260:Female; D015603:Keratinocytes / Q000378:metabolism*; D007801:Langerhans Cells / Q000378:metabolism*; D008297:Male; D053773:Transforming Growth Factor beta1 / Q000096:biosynthesis*
chemical_list: D053773:Transforming Growth Factor beta1