title: Hepatitis C virus infection and type 2 diabetes mellitus in Mexican patients.
abstract: OBJECTIVE
  to measure the frequency of type 2 diabetes mellitus (T2DM) in patients with confirmed HCV infection.
  
  
  METHODS
  we studied 125 adults reactive to anti-HCV antibodies (62.4 % women, mean age 46.8 years) who received confirmatory RT-PCR testing for viremia (63.2 % HCV-RNA-positive).
  
  
  RESULTS
  twenty-two patients had T2DM (17.6 %, 95 % confidence interval: 11.8-25.3 %; mean National prevalence: 14.4 %), more frequent among patients with detectable viremia than in negative cases (23.3 % vs. 9.6 %, respectively; p = 0.04), and among those with advanced liver disease, than in compensated patients (28.9 % vs. 11.3 %, respectively; p = 0.01). Fourteen (17.7 %) patients received interferon-based treatment and 6 (42.8 %) had sustained virology response. None of the 6 responders had T2DM, but 2 of the 8 (25 %) non-responders had diabetes. T2DM patients were older than those without diabetes (57.7 vs. 44.5 years, p < 0.001), and after multivariate analysis, only age was significantly associated with diagnosis of T2DM.
  
  
  CONCLUSIONS
  T2DM was highly prevalent among patients with chronic HCV infection. Age was the most important determining factor.
authors.affiliation: Division of Internal Medicine, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México. erwinchiquete@runbox.com.mx
authors.forename: Erwin
authors.initials: E
authors.lastname: Chiquete
authors.forename: Ana
authors.initials: A
authors.lastname: Ochoa-Guzmán
authors.forename: Leopoldo
authors.initials: L
authors.lastname: García-Lamas
authors.forename: Francisco
authors.initials: F
authors.lastname: Anaya-Gómez
authors.forename: Juan I
authors.initials: JI
authors.lastname: Gutiérrez-Manjarrez
authors.forename: Laura V
authors.initials: LV
authors.lastname: Sánchez-Orozco
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Godínez-Gutiérrez
authors.forename: Montserrat
authors.initials: M
authors.lastname: Maldonado
authors.forename: Sonia
authors.initials: S
authors.lastname: Román
authors.forename: Arturo
authors.initials: A
authors.lastname: Panduro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult