title: A probabilistic coevolutionary biclustering algorithm for discovering coherent patterns in gene expression dataset.
abstract: BACKGROUND
  Biclustering has been utilized to find functionally important patterns in biological problem. Here a bicluster is a submatrix that consists of a subset of rows and a subset of columns in a matrix, and contains homogeneous patterns. The problem of finding biclusters is still challengeable due to computational complex trying to capture patterns from two-dimensional features.
  
  
  RESULTS
  We propose a Probabilistic COevolutionary Biclustering Algorithm (PCOBA) that can cluster the rows and columns in a matrix simultaneously by utilizing a dynamic adaptation of multiple species and adopting probabilistic learning. In biclustering problems, a coevolutionary search is suitable since it can optimize interdependent subcomponents formed of rows and columns. Furthermore, acquiring statistical information on two populations using probabilistic learning can improve the ability of search towards the optimum value. We evaluated the performance of PCOBA on synthetic dataset and yeast expression profiles. The results demonstrated that PCOBA outperformed previous evolutionary computation methods as well as other biclustering methods.
  
  
  CONCLUSIONS
  Our approach for searching particular biological patterns could be valuable for systematically understanding functional relationships between genes and other biological components at a genome-wide level.
authors.affiliation: Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, 151-742, Korea.
authors.forename: Je-Gun
authors.initials: JG
authors.lastname: Joung
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Soo-Yong
authors.initials: SY
authors.lastname: Shin
authors.forename: Byoung-Tak
authors.initials: BT
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D019143:Evolution, Molecular; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000706:statistics & numerical data*; D020411:Oligonucleotide Array Sequence Analysis / Q000706:statistics & numerical data*; D012441:Saccharomyces cerevisiae / Q000235:genetics