title: Magnetic resonance imaging and spectroscopy of the murine cardiovascular system.
abstract: Magnetic resonance imaging (MRI) has emerged as a powerful and reliable tool to noninvasively study the cardiovascular system in clinical practice. Because transgenic mouse models have assumed a critical role in cardiovascular research, technological advances in MRI have been extended to mice over the last decade. These have provided critical insights into cardiac and vascular morphology, function, and physiology/pathophysiology in many murine models of heart disease. Furthermore, magnetic resonance spectroscopy (MRS) has allowed the nondestructive study of myocardial metabolism in both isolated hearts and in intact mice. This article reviews the current techniques and important pathophysiological insights from the application of MRI/MRS technology to murine models of cardiovascular disease.
authors.affiliation: Division of Cardiology, Department of Medicine, and Division of Magnetic Resonance Research, Department of Radiology, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
authors.forename: Ashwin
authors.initials: A
authors.lastname: Akki
authors.forename: Ashish
authors.initials: A
authors.lastname: Gupta
authors.forename: Robert G
authors.initials: RG
authors.lastname: Weiss
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000473:pathology* / Q000503:physiopathology*; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000033:anatomy & histology / Q000473:pathology*; D004195:Disease Models, Animal; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D051379:Mice