title: LIM-domain-only proteins in cancer.
abstract: LIM-domain proteins are a large family of proteins that are emerging as key molecules in a wide variety of human cancers. In particular, all members of the human LIM-domain-only (LMO) proteins, LMO1-4, which are required for many developmental processes, are implicated in the onset or the progression of several cancers, including T cell leukaemia, breast cancer and neuroblastoma. These small proteins contain two protein-interacting LIM domains but little additional sequence, and they seem to function by nucleating the formation of new transcriptional complexes and/or by disrupting existing transcriptional complexes to modulate gene expression programmes. Through these activities, the LMO proteins have important cellular roles in processes that are relevant to cancer such as self-renewal, cell cycle regulation and metastasis. These functions highlight the therapeutic potential of targeting these proteins in cancer.
authors.affiliation: School of Molecular Bioscience, The University of Sydney, New South Wales 2006, Australia. jacqui.matthews@ sydney.edu.au
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Matthews
authors.forename: Krystal
authors.initials: K
authors.lastname: Lester
authors.forename: Soumya
authors.initials: S
authors.lastname: Joseph
authors.forename: David J
authors.initials: DJ
authors.lastname: Curtis
mesh_terms: D000818:Animals; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D060588:LIM Domain Proteins / Q000235:genetics* / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D054730:Protein Interaction Domains and Motifs
chemical_list: D060588:LIM Domain Proteins