title: Cell-penetrating peptides (CPPs) as a vector for the delivery of siRNAs into cells.
abstract: "Cell-penetrating peptides (CPPs)" is an inclusive term describing relatively small peptides (6-30 amino acid residues) having membrane translocation activity. Due to their efficacy in cellular internalisation and the accompanying low cytotoxicity, CPPs are regarded as promising vectors for intracellular delivery of various membrane-impermeable bioactive molecules. This review provides an overview of the current approaches and describes the potential of CPP-based siRNA delivery systems, specifically those using arginine-rich CPPs.
authors.affiliation: Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
authors.forename: Ikuhiko
authors.initials: I
authors.lastname: Nakase
authors.forename: Gen
authors.initials: G
authors.lastname: Tanaka
authors.forename: Shiroh
authors.initials: S
authors.lastname: Futaki
mesh_terms: D000595:Amino Acid Sequence; D001120:Arginine / Q000737:chemistry / Q000235:genetics; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D057846:Cell-Penetrating Peptides / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D005822:Genetic Vectors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D034741:RNA, Small Interfering / Q000235:genetics*; D015203:Reproducibility of Results; D014162:Transfection / Q000379:methods*
chemical_list: D057846:Cell-Penetrating Peptides; D034741:RNA, Small Interfering; D001120:Arginine