title: The buccal mucosa fenestrated graft for Bracka first stage urethroplasty: experimental study in rabbits.
abstract: OBJECTIVE
  To histologically evaluate, in an experimental study in rabbits, the integration process of the buccal mucosa fenestrated graft applied in the corpora cavernosa for Bracka first stage urethroplasty.
  
  
  METHODS
  A urethral defect was surgically created in 16 male rabbits of the New Zealand breed through the excision of the penile urethra. The urethral defect was corrected by applying buccal mucosa fenestrated graft through two cruciform incisions in the distal portions of its longitudinal axis. The animals were sacrificed at 2, 4, 8 and 12 weeks post surgery and their genitals were subjected to clinical and histological assessment.
  
  
  RESULTS
  The buccal mucosa fenestrated graft showed complete uptake in all groups, with keratinization squamous metaplasia and mucosal proliferation of the fenestrated areas. The fenestrated graft area represented an increase in length of 25 % in length in relation to the original standard graft.
  
  
  CONCLUSIONS
  The fenestrated buccal mucosa graft presented total integration to the adjacent epithelia with re-epithelization of the incision areas of the graft (fenestrations) and no significant inflammatory or scarring reactions when compared to other mucosa transplanted areas; therefore its application is viable in cases of extensive urethral defect whenever the donating area might be insufficient.
authors.affiliation: Departament of Urology, Federal University of São Paulo, Rua Maestro Cardim 560, São Paulo, Brazil.
authors.forename: Petrus
authors.initials: P
authors.lastname: Oliva
authors.forename: Rosana
authors.initials: R
authors.lastname: Delcelo
authors.forename: Herick
authors.initials: H
authors.lastname: Bacelar
authors.forename: Atila
authors.initials: A
authors.lastname: Rondon
authors.forename: Ubirajara
authors.initials: U
authors.lastname: Barroso
authors.forename: Valdemar
authors.initials: V
authors.lastname: Ortiz
authors.forename: Antonio
authors.initials: A
authors.lastname: Macedo
mesh_terms: D000818:Animals; D008297:Male; D023421:Models, Animal; D009061:Mouth Mucosa / Q000637:transplantation*; D011817:Rabbits; D015203:Reproducibility of Results; D013997:Time Factors; D016896:Treatment Outcome; D014521:Urethra / Q000473:pathology / Q000601:surgery*; D014525:Urethral Stricture / Q000601:surgery*