title: MIC values of voriconazole are predictive of treatment results in murine infections by Aspergillus terreus species complex.
abstract: We evaluated the efficacy of voriconazole against nine strains of Aspergillus terreus with different MICs (0.12 to 4 μg/ml) by using a murine model. Markers of efficacy included survival, tissue burden, galactomannan antigenemia, and drug serum levels. Voriconazole was especially effective in prolonging survival and reducing the fungal load in infections by strains that showed MICs that were less than or equal to the epidemiological cutoff value (1 μg/ml). In vitro data might be useful for predicting the outcome of A. terreus infections.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Valentina
authors.initials: V
authors.lastname: Salas
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Pastor
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.forename: Enrique
authors.initials: E
authors.lastname: Calvo
authors.forename: Emilio
authors.initials: E
authors.lastname: Mayayo
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology / Q000401:mortality; D001230:Aspergillus / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D025141:Drug Resistance, Fungal / Q000187:drug effects; D005690:Galactose / Q000031:analogs & derivatives; D008297:Male; D008351:Mannans / Q000037:antagonists & inhibitors / Q000276:immunology; D051379:Mice; D008826:Microbial Sensitivity Tests; D011379:Prognosis; D011743:Pyrimidines / Q000494:pharmacology*; D016019:Survival Analysis; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D008351:Mannans; D011743:Pyrimidines; D014230:Triazoles; C012990:galactomannan; D000666:Amphotericin B; D065819:Voriconazole; D005690:Galactose