title: Preliminary pharmacokinetic study of repeated doses of rifampin and rifapentine in guinea pigs.
abstract: Substitution of rifapentine (RFP) for rifampin (RIF) in the standard antituberculous regimen reduces the time required to cure chronic tuberculosis (TB) infection in mice, but not in guinea pigs. In order to gain insight into these discrepant findings, we conducted a steady-state pharmacokinetic (PK) study in healthy guinea pigs to study the metabolism and autoinduction of RIF and RFP. Both RFP and RIF 25-desacetyl metabolites (desRFP and desRIF, respectively), were detected at low concentrations in the serum of guinea pigs. The metabolite concentrations in guinea pigs are much lower than those seen in humans at steady state.
authors.affiliation: Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Noton K
authors.initials: NK
authors.lastname: Dutta
authors.forename: Abdullah
authors.initials: A
authors.lastname: Alsultan
authors.forename: Charles A
authors.initials: CA
authors.lastname: Peloquin
authors.forename: Petros C
authors.initials: PC
authors.lastname: Karakousis
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D004334:Drug Administration Schedule; D005260:Female; D006168:Guinea Pigs; D058507:Host Specificity; D006801:Humans; D051379:Mice; D012293:Rifampin / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000995:Antitubercular Agents; D012293:Rifampin; C018421:rifapentine