title: Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation.
abstract: There is much evidence that neuropeptide substance P is involved in neurogenic inflammation and is an important neurotransmitter and neurmodulator compound. In addition, substance P plays an important role in inflammation and immunity. Macrophages can be activated by substance P which provokes the release of inflammatory compounds such as interleukins, chemokines and growth factors. Substance P is involved in the mechanism of pain through the trigeminal nerve which runs through the head, temporal and sinus cavity. Substance P also activates mast cells to release inflammatory mediators such as arachindonic acid compound, cytokines/chemokines and histamine. The release of these chemical mediators is crucial for inflammatory response. Among these mediators there are prostoglandins and leukotrines. Here we review the impact of substance P on inflammatory compounds.
authors.forename: M
authors.initials: M
authors.lastname: Nicoletti
authors.forename: G
authors.initials: G
authors.lastname: Neri
authors.forename: G
authors.initials: G
authors.lastname: Maccauro
authors.forename: D
authors.initials: D
authors.lastname: Tripodi
authors.forename: G
authors.initials: G
authors.lastname: Varvara
authors.forename: A
authors.initials: A
authors.lastname: Saggini
authors.forename: G
authors.initials: G
authors.lastname: Potalivo
authors.forename: M L
authors.initials: ML
authors.lastname: Castellani
authors.forename: M
authors.initials: M
authors.lastname: Fulcheri
authors.forename: M
authors.initials: M
authors.lastname: Rosati
authors.forename: E
authors.initials: E
authors.lastname: Toniato
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.forename: P
authors.initials: P
authors.lastname: Antinolfi
authors.forename: G
authors.initials: G
authors.lastname: Cerulli
authors.forename: F
authors.initials: F
authors.lastname: Pandolfi
authors.forename: R
authors.initials: R
authors.lastname: Galzio
authors.forename: P
authors.initials: P
authors.lastname: Conti
authors.forename: T C
authors.initials: TC
authors.lastname: Theoharides
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000096:biosynthesis* / Q000276:immunology; D002199:Capillary Permeability; D015232:Dinoprostone / Q000502:physiology; D006801:Humans; D018040:Receptors, Neurokinin-1 / Q000502:physiology; D013373:Substance P / Q000502:physiology*
chemical_list: D018040:Receptors, Neurokinin-1; D016718:Arachidonic Acid; D013373:Substance P; D015232:Dinoprostone