title: Matrix metalloproteinase-12 is associated with overall survival in Chinese patients with gastric cancer.
abstract: OBJECTIVE
  Matrix metalloproteinase-12 (MMP-12) plays an important role in invasion and metastasis of human solid tumor cells. This study aimed to investigate the association of MMP-12 with overall survival in human gastric cancer.
  
  
  METHODS
  Gastric cancer and adjacent normal tissue specimens were collected from 165 patients who had not received neoadjuvant chemotherapy. MMP-12 expression was determined by immunohistochemical staining, and the results were analyzed statistically in relation to the overall survival of the patients.
  
  
  RESULTS
  MMP-12 expression was increased in gastric cancer compared with that observed in normal tissues. Increased MMP-12 expression was associated with tumor invasion, lymph node metastasis, distant metastasis, and TNM stage. No correlations were detected between MMP-12 expression and age, sex, differentiation status, tumor site, or Lauren classification. Moreover, patients with MMP-12 positive gastric cancer tended to have worse overall survival compared with those patients without MMP-12 expression.
  
  
  CONCLUSIONS
  The study results showed that increased expression of MMP-12 was associated with tumor progression in gastric cancer. It also provided the first evidence for MMP-12 expression in gastric cancer as an independent prognostic factor.
authors.affiliation: Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China. zhengjy3699@yahoo.com.cn
authors.forename: Jianyong
authors.initials: J
authors.lastname: Zheng
authors.forename: Dake
authors.initials: D
authors.lastname: Chu
authors.forename: Desheng
authors.initials: D
authors.lastname: Wang
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xiaoyin
authors.initials: X
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Ji
authors.forename: Haihong
authors.initials: H
authors.lastname: Zhao
authors.forename: Guosheng
authors.initials: G
authors.lastname: Wu
authors.forename: Jianjun
authors.initials: J
authors.lastname: Du
authors.forename: Qingchuan
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002681:China / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D053508:Matrix Metalloproteinase 12 / Q000032:analysis*; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D053508:Matrix Metalloproteinase 12