title: 1H NMR detection of small molecules in human urine with a deep cavitand synthetic receptor.
abstract: A water-soluble deep cavitand recognized alkylammonium salts, including the drug amantadine hydrochloride, in spiked samples of human urine. The signals of the guests are detected by (1)H NMR upfield of 0 ppm and so occur in a spectroscopic window that is outside of the normal region and distinct from the signals of the biofluid components.
authors.affiliation: The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Ryan
authors.forename: Julius
authors.initials: J
authors.lastname: Rebek
mesh_terms: D000547:Amantadine / Q000652:urine*; D004988:Ethers, Cyclic / Q000737:chemistry*; D006801:Humans; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D062165:Receptors, Artificial / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry*
chemical_list: D004988:Ethers, Cyclic; D062165:Receptors, Artificial; D012118:Resorcinols; C442939:cavitand; D006859:Hydrogen; D000547:Amantadine