title: MicroRNAs in androgen-dependent PCa.
abstract: Prostate cancer (PCa) is the most commonly diagnosed cancer among men in Western countries and is one of the leading causes of cancer deaths. The growth and progression of PCa is related to androgen levels. In cancer, nicroRNAs (miRs) function as either oncogenes or tumor suppressor genes. In androgen-dependent PCa, miRs play a role in the growth, development, progression, and metastasis of the disease, and are also involved in the response to therapy and therefore affect the prognosis. In this review, we focus on the role played by miRs concerning the mechanisms of androgen-dependent PCa.
authors.affiliation: Department of Neonatology, Fengxian Branch of Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 201499, China.
authors.forename: Kai-Chang
authors.initials: KC
authors.lastname: Zhu
authors.forename: Jia-ju
authors.initials: JJ
authors.lastname: Lu
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Xu
authors.forename: Jian-mei
authors.initials: JM
authors.lastname: Sun
mesh_terms: D000728:Androgens / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology / Q000627:therapeutic use; D009362:Neoplasm Metastasis / Q000235:genetics; D009376:Neoplasms, Hormone-Dependent / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D011944:Receptors, Androgen / Q000235:genetics / Q000502:physiology
chemical_list: D000728:Androgens; D035683:MicroRNAs; D011944:Receptors, Androgen; C531888:MIRN125 microRNA, human; C533895:MIRN141 microRNA, human; C534425:MIR205, human; C524940:MIRN21 microRNA, human; C487931:mirnlet7 microRNA, human