title: Increased vertebral morphometric fracture in patients with postsurgical hypoparathyroidism despite normal bone mineral density.
abstract: BACKGROUND
  The mechanism behind parathyroid hormone (PTH) activation of bone remodeling is intimately dependent on the time of exposure of bone cells to hormone levels. Sustained high PTH levels trigger catabolism, while transitory elevations induce anabolism. The effects of hypoparathyroidism (PhPT) on bone are unknown. The objective was to study the impact of PhPT on bone mineral density (BMD), on the frequency of subclinical vertebral fracture and on mandible morphometry.
  
  
  METHODS
  The study comprised thirty-three postmenopausal women, 17 controls (CG) and 16 with PhPT (PhPTG) matched for age, weight and height. Bone mineral density (BMD) of lumbar spine, total hip and 1/3 radius, radiographic evaluation of vertebral morphometry, panoramic radiography of the mandible, and biochemical evaluation of mineral metabolism and bone remodeling were evaluated in both groups.
  
  
  RESULTS
  There were no significant differences in lumbar spine or total hip BMD between groups. There was marked heterogeneity of lumbar spine BMD in PhPTG (high = 4, normal = 9, osteopenia = 1, and osteoporosis = 2 patients). BMD was decreased in the 1/3 radius in PhPTG P < 0.005). The PhPTG group exhibited an increased frequency of morphometric vertebral fractures and decreased mandible cortical thickness.
  
  
  CONCLUSIONS
  The study suggests that vertebral fragility occurs in PhPT despite normal or even high BMD. The current results encourage further studies to evaluate the use of panoramic radiography in the identification of osteometabolic disorders, such as PhPT and the development of a more physiological treatment for PhPT.
authors.affiliation: Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. fjpaula@fmrp.usp.br.
authors.forename: Maira L
authors.initials: ML
authors.lastname: Mendonça
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Pereira
authors.forename: Marcello H
authors.initials: MH
authors.lastname: Nogueira-Barbosa
authors.forename: Lucas M
authors.initials: LM
authors.lastname: Monsignore
authors.forename: Sara R
authors.initials: SR
authors.lastname: Teixeira
authors.forename: Plauto Ca
authors.initials: PC
authors.lastname: Watanabe
authors.forename: Lea Mz
authors.initials: LM
authors.lastname: Maciel
authors.forename: Francisco Ja
authors.initials: FJ
authors.lastname: de Paula