title: [Correlation between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease].
abstract: OBJECTIVE
  To discuss the occurrence correlation between obstructive sleep apnea hypopnea syndrome (OSAHS) and gastroesophageal reflux disease (GERD).
  
  
  METHODS
  Forty-three patients suspected of laryngopharyngeal reflux disease underwent combined multichannel intraluminal impedance and esophageal manometry (MII-EM), twenty-four-hour esophageal and pharyngeal pH and impedance monitoring and PSG. Subjects were grouped according to the detections. The difference of the measurement between groups were Compared. The possible relationship between the two diseases was analyzed.
  
  
  RESULTS
  Fourteen of all the subjects can be diagnosed to have GERD (32.6%). Twenty-six can be diagnosed to have OSAHS (60.5%). There were 10 patients had OSAHS and GERD simultaneously, which took over 38.5% of the OSAHS group, and 71.4% of the GERD group. BMI (P = 0.000) and lower esophageal sphincter (LES) residual pressure (P = 0.021) were significantly different among the four groups OSAHS, GERD, OSAHS and GERD, and control (non-OSAHS and non-GERD), but no linear relationship between LES residual pressure and prevalence or severity of the two diseases was found. In OSAHS group, AHI were positively correlated with the following indictors: the DeMeester score (r = 0.45), acid exposure of the distal esophagus (r = 0.491). There seems to be no Linear correlation among reflux indicators, sleep indicators, and esophageal functional indicators in GERD group. Linear correlation was not found among reflux indicators, sleep indicators, and esophageal functional indicators in OSAHS and GERD group (P > 0.05).
  
  
  CONCLUSIONS
  The incidence and the severity of GERD and OSAHS were related to each other. Reflux events may aggravate OSAHS. The two diseases may have some relationship on the esophageal function, especially on the regulation of the LES pressure.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otorhinolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing 100730, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Qu
authors.forename: Jing-ying
authors.initials: JY
authors.lastname: Ye
authors.forename: Li
authors.initials: L
authors.lastname: Zheng
authors.forename: Yu-huan
authors.initials: YH
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D017097:Electric Impedance; D004947:Esophagus / Q000503:physiopathology*; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D006801:Humans; D008365:Manometry; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*; D013270:Stomach / Q000503:physiopathology; D055815:Young Adult