title: Diagnostic nomenclature for foetal alcohol spectrum disorders: the continuing challenge of causality.
abstract: Prenatal alcohol exposure is a risk factor for neurologically based cognitive and adaptive disability. Diagnostic nomenclature for prenatally exposed children with cognitive and adaptive disability who lack features for foetal alcohol syndrome (FAS) or partial FAS includes the terms alcohol-related neurodevelopmental disorder (ARND) and foetal alcohol spectrum disorder(s) (FASD). Although these terms are now widely used, this paper argues that both are problematic. ARND is flawed by unjustifiably turning a risk factor into a causal factor and shrouding the result in terminological ambiguity, while FASD is not appropriate as a clinical label, and its use as a proxy for ARND deflects critical attention from the causal inferencing that is integral to diagnosing children with an alcohol-related teratogenic condition. Existing nomenclature is at odds with logical and evidence-based diagnosing and also has implications for interpretation of epidemiological data. Diagnostic nomenclature that is not tightly linked to causal inference is preferable at the present stage of this field's development.
authors.affiliation: Division of Developmental Pediatrics, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada; Developmental Neurosciences & Child Health, Child & Family Research Institute, Vancouver, BC, Canada; Sunny Hill Health Centre for Children, Vancouver, BC, Canada.
authors.forename: A R
authors.initials: AR
authors.lastname: Miller
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D015984:Causality; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000145:classification / Q000175:diagnosis*; D006801:Humans; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012660:Semantics; D064793:Teratogenesis; D009626:Terminology as Topic
keywords: alcohol-related neurodevelopmental disorder; causality; foetal alcohol spectrum disorder(s); prenatal alcohol exposure; teratogenesis