title: Regulatory issues in management of chemicals in OECD member countries.
abstract: The chemical risk assessment is determinant for the approval of any kind of chemical. Each aspect of chemical is taken into consideration for the new chemical legislation registration, evaluation, and authorization of chemicals (REACH). However, some improvements can be made in order to select and authorize a chemical. QSAR techniques have been used for the study of several kind of toxicological properties in order to realize a deeper study concerning to risk assessment. For this reason, this work is focused into present a review of chemical legislation policies in the European Union (EU) and in Russia, and changes in chemicals regulations to meet the requirement of REACH. Also, we reported the used of several approaches and chemo- bioinformatics tools applied to QSAR methodologies for the several parameters relative to toxicity and how they can be used for regulatory purposes in risk assessment.
authors.affiliation: Faculty of Technology and Production Management, Moscow State University of Food Production, Volokolamskoe shosse 11, 125080 Moscow, Russia. k_valeriya@msn.com
authors.forename: Valeria V
authors.initials: VV
authors.lastname: Kleandrova
authors.forename: Alejandro
authors.initials: A
authors.lastname: Speck-Planche
mesh_terms: D019295:Computational Biology / Q000331:legislation & jurisprudence* / Q000379:methods; D004781:Environmental Exposure / Q000592:standards*; D005062:European Union; D033161:Government Regulation; D015386:Hazardous Substances / Q000145:classification* / Q000592:standards; D021281:Quantitative Structure-Activity Relationship; D018570:Risk Assessment / Q000331:legislation & jurisprudence* / Q000379:methods; D012426:Russia
chemical_list: D015386:Hazardous Substances