title: [Association of interferon-γ gene polymorphism and risk of cervical HPV infection].
abstract: OBJECTIVE
  To investigate the association of interferon (IFN) γ gene polymorphisms and risk and prognosis of HPV cervical infection.
  
  
  METHODS
  PCR-ASP was used for detecting IFN-γ rs2430561 polymorphism in 179 HPV positive patients and 328 HPV negative normal controls.
  
  
  RESULTS
  The frequency of A allele of 63.7% (228/358) was significantly higher than the frequency of T allele of 36.3% (130/358) in HPV positive group (P = 0.045). The frequencies were 41.3% (74/179) in AA genotype and 14.0% (25/179) in TT genotype, women carrying AA genotype increased the risk of HPV infection compare with those with TT genotype (OR = 1.784, 95% CI: 1.031 - 3.088, P = 0.039). During follow-up, the rate of HPV positive again in AA genotype was 83.8% (62/74), while TT genotype was 20.0% (5/25). In the analysis of Kaplan-Meier, the cumulative HPV negative rates of AA, TA and TT genotype exhibited significantly different (P = 0.008). The cumulative HPV negative rate of AA genotype was the lowest (1.1% - 5.9%).
  
  
  CONCLUSIONS
  IFN-γ rs2430561 polymorphisms confer the susceptibility to HPV infection. Women with AA genotype exhibited higher risk of infection and inclined to be continuous status and recurrence after HPV infection.
authors.affiliation: Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110004, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Yan-ming
authors.initials: YM
authors.lastname: Lu
authors.forename: Shi-zhuo
authors.initials: SZ
authors.lastname: Wang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Xiao
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Heng
authors.initials: H
authors.lastname: Wei
authors.forename: Duo
authors.initials: D
authors.lastname: Yin
authors.forename: Ling
authors.initials: L
authors.lastname: Ouyang
authors.forename: Shu-lan
authors.initials: SL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D002577:Uterine Cervical Diseases / Q000235:genetics* / Q000821:virology*
chemical_list: D007371:Interferon-gamma