title: [The clinical characteristics of 169 cases of severe fever with thrombocytopenia syndrome].
abstract: OBJECTIVE
  To analyze the clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) so as to improve the recognition of the emerging infectious disease.
  
  
  METHODS
  A retrospective analysis was performed upon clinical manifestations, laboratory test results and prognostic features of 169 patients with SFTS admitted to the 154 Hospital, Chinese People's Liberation Army from October 2010 to May 2011. The patients were divided into moderate disease group and severe disease group according to the prognosis. The differences between two groups were compared to explore the prognostic indicator of severe type.
  
  
  RESULTS
  All patients with SFTS inhabited in hilly ground with history of field work. The main clinical symptoms were severe fever (98.8%, 167/169), headache (52.1%, 88/169), muscle soreness (95.9%, 162/169), nausea (73.4%, 124/169), vomiting (67.5%, 114/169), coughing (61.5%, 104/169), etc. Superficial lymph node enlargement with haphalgesia was observed in 45.0% (76/169) patients. Petechia or ecchymosis was observed in 36.7% (62/169) patients. Critical patients were mainly aged > 60 years, associated with nerve and circulatory system syndrome, prominent hemoptysis, dyspnea, and nearly 73.3% (22/30) of severe thrombocytopenia. Serum levels of aspartate aminotransferase, creatinine and urea nitrogen were significantly higher in severe disease group than those in moderate disease group [235 (47 - 1750) U/L vs 88 (14 - 2000) U/L, 997(281 - 2601) U/L vs 399 (26 - 2633) U/L, 101 (62 - 291) µmol/L vs 70 (26 - 205) µmol/L, 7.0 (2.2 - 20.0) mmol/L vs 4.8 (1.4 - 18.5) mmol/L, all P values < 0.001].
  
  
  CONCLUSIONS
  Nerves system syndrome, transaminase and urea nitrogen are risk factors of prognosis of severe SFTS to whom deserves paying attention.
authors.affiliation: Department of Infectious Diseases, the 154 Hospital, Chinese People's Liberation Army, Henan Province, Xinyang 464000, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Cui
authors.forename: Zhen-dong
authors.initials: ZD
authors.lastname: Yang
authors.forename: Bing-jun
authors.initials: BJ
authors.lastname: Wang
authors.forename: Xue-juan
authors.initials: XJ
authors.lastname: Fan
authors.forename: Chun
authors.initials: C
authors.lastname: Yuan
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005334:Fever / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000150:complications*