title: Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels.
abstract: PTX3 is a long pentraxin of the innate immune system produced by different cell types (mononuclear phagocytes, dendritic cells, fibroblasts and endothelial cells) at the inflammatory site. It appears to have a cardiovascular protective function by acting on the immune-inflammatory balance in the cardiovascular system. PTX3 plasma concentration is an independent predictor of mortality in patients with acute myocardial infarction (AMI) but the influence of PTX3 genetic variants on PTX3 plasma concentration has been investigated very little and there is no information on the association between PTX3 variations and AMI. Subjects of European origin (3245, 1751 AMI survivors and 1494 controls) were genotyped for three common PTX3 polymorphisms (SNPs) (rs2305619, rs3816527, rs1840680). Genotype and allele frequencies of the three SNPs and the haplotype frequencies were compared for the two groups. None of the genotypes, alleles or haplotypes were significantly associated with the risk of AMI. However, analysis adjusted for age and sex indicated that the three PTX3 SNPs and the corresponding haplotypes were significantly associated with different PTX3 plasma levels. There was also a significant association between PTX3 plasma concentrations and the risk of all-cause mortality at three years in AMI patients (OR 1.10, 95% CI: 1.01-1.20, p = 0.02). Our study showed that PTX3 plasma levels are influenced by three PTX3 polymorphisms. Genetically determined high PTX3 levels do not influence the risk of AMI, suggesting that the PTX3 concentration itself is unlikely to be even a modest causal factor for AMI. Analysis also confirmed that PTX3 is a prognostic marker after AMI.
authors.affiliation: Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Barbati
authors.forename: Claudia
authors.initials: C
authors.lastname: Specchia
authors.forename: Massimo
authors.initials: M
authors.lastname: Villella
authors.forename: Marco Luciano
authors.initials: ML
authors.lastname: Rossi
authors.forename: Simona
authors.initials: S
authors.lastname: Barlera
authors.forename: Barbara
authors.initials: B
authors.lastname: Bottazzi
authors.forename: Luisa
authors.initials: L
authors.lastname: Crociati
authors.forename: Carmela
authors.initials: C
authors.lastname: d'Arienzo
authors.forename: Raffaele
authors.initials: R
authors.lastname: Fanelli
authors.forename: Cecilia
authors.initials: C
authors.lastname: Garlanda
authors.forename: Francesca
authors.initials: F
authors.lastname: Gori
authors.forename: Ruggiero
authors.initials: R
authors.lastname: Mango
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Merla
authors.forename: Enrico B
authors.initials: EB
authors.lastname: Nicolis
authors.forename: Silvia
authors.initials: S
authors.lastname: Pietri
authors.forename: Patrizia
authors.initials: P
authors.lastname: Presbitero
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sudo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Villella
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Franzosi
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000378:metabolism; D001774:Blood Chemical Analysis; D002097:C-Reactive Protein / Q000032:analysis* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000235:genetics*; D009994:Osmolar Concentration; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012307:Risk Factors; D000683:Serum Amyloid P-Component / Q000032:analysis* / Q000235:genetics*; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins