title: Cardiac consequences of anti-inflammatory drugs in experimental models.
abstract: Although heart failure is predominantly caused by cardiovascular conditions such as hypertension, coronary heart disease and valvular heart disease, it can also be caused by adverse drug reactions. Several medications have been shown to have cardiotoxic effects. Among those therapeutic agents, anti-inflammatory drugs, including exogenous glucocorticoids, nonsteroidal anti-inflammatory drugs and biologics, which are used to treat a broad range of diseases that are associated with inflammatory processes, are widely prescribed in clinical practice. In this review, we discuss insights from experimental models on the beneficial and cardiotoxic effects of anti-inflammatory drugs.
authors.affiliation: Montreal Heart Institute, Research Center, 5000 Belanger Est, Montreal, QC, Canada. nolwenn.merlet@gmail.com
authors.forename: Nolwenn
authors.initials: N
authors.lastname: Merlet
authors.forename: David
authors.initials: D
authors.lastname: Busseuil
authors.forename: Éric
authors.initials: É
authors.lastname: Rhéaume
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Tardif
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D004195:Disease Models, Animal; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D051379:Mice; D032342:Muscle Cells / Q000187:drug effects; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids