title: Preparation of PNIPAM-g-P (NIPAM-co-St) microspheres and their blood compatibility.
abstract: The poly(N-isopropylacrylamide)-g-poly(N-isopropylacrylamide-co-styrene) microspheres (PNNS-MSs) were prepared by an emulsifier-free emulsion polymerization method. The blood compatibility of PNNS-MSs was characterized by in vitro for coagulation tests, hemolysis assay, plasma recalcification time, complement activation, platelet activation, and cytotoxicity experiments. The results showed that the PNNS-MSs have good blood compatibility and lack cytotoxicity, which may be attributed to the formation of a strong interfacial hydration layer that result from amphiphilic molecular structure of the PNIPAM shell and minimal interaction between PNNS-MSs interfaces and blood components. The PNNS-MSs provide a promising platform of blood circulation system for early illness diagnosis and therapy.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Qinshu
authors.initials: Q
authors.lastname: Zhu
authors.forename: Libin
authors.initials: L
authors.lastname: Chen
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Zhu
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Luan
authors.forename: Chun
authors.initials: C
authors.lastname: Mao
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000925:Anticoagulants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects*; D006461:Hemolysis; D006801:Humans; D008863:Microspheres; D010316:Particle Size; D011817:Rabbits; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D000925:Anticoagulants; D001672:Biocompatible Materials; C582910:poly(N-isopropylacrylamide)-g-poly(N-isopropylacrylamide-co-styrene)