title: Apathy and white matter integrity in Alzheimer's disease: a whole brain analysis with tract-based spatial statistics.
abstract: The aim of this study was to investigate the microstructural alterations of white matter (WM) in Alzheimer's disease (AD) patients with apathy and to observe the relationships with the severity of apathy. Sixty drug-naïve subjects took part in this study (30 apathetic and 30 nonapathetic subjects with AD). The loss of integrity in WM was compared in AD patients with and without apathy through measurement of fractional anisotropy (FA) using by tract-based spatial statistics (TBSS). In addition, we explored the correlation pattern between FA values and the severity of apathy in AD patients with apathy. The apathy group had significantly reduced FA values (p(corrected)<0.05) in the genu of the corpus callosum compared to the nonapathy group. The severity of apathy was negatively correlated with FA values of the left anterior and posterior cingulum, right superior longitudinal fasciculus, splenium, body and genu of the corpus callosum and bilateral uncinate fasciculusin the apathy group (p(corrected)<0.05). This study was the first to explore FA values in whole brain WM in AD patients with apathy. The findings of these microstructural alterations of WM may be the key to the understanding of underlying neurobiological mechanism and clinical significances of apathy in AD.
authors.affiliation: Department of Psychiatry, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Changtae
authors.initials: C
authors.lastname: Hahn
authors.forename: Hyun-Kook
authors.initials: HK
authors.lastname: Lim
authors.forename: Wang Yeon
authors.initials: WY
authors.lastname: Won
authors.forename: Kook Jin
authors.initials: KJ
authors.lastname: Ahn
authors.forename: Won-Sang
authors.initials: WS
authors.lastname: Jung
authors.forename: Chang Uk
authors.initials: CU
authors.lastname: Lee
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D016880:Anisotropy; D057565:Apathy; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D003337:Corpus Callosum / Q000378:metabolism / Q000503:physiopathology*; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D015233:Models, Statistical; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D015203:Reproducibility of Results