title: An efficient organocatalytic enantioselective Michael addition of aryl methyl ketones with 2-furanones: highly functionalized chiral 3,4-substituted lactones.
abstract: The efficient asymmetric Michael addition reactions of aryl methyl ketones with 2-furanones were catalyzed by a simple and commercially available chiral 1,2-diphenyl-1,2-ethanediamine and p-TSA·H(2)O as cocatalyst with good yields (up to 95%) and excellent enantioselectivities (up to >99% ee). A bi-functional catalytic mechanism for the reaction was proposed.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Junfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhou
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.forename: Zemei
authors.initials: Z
authors.lastname: Ge
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Runtao
authors.initials: R
authors.lastname: Li
mesh_terms: D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D005663:Furans; D007659:Ketones; D007783:Lactones