title: Highly stereoselective synthesis of (Z)- and (E)-chloro-substituted-α-methylene-γ-butyrolactone by possibly controlling cis- and trans-chloropalladation.
abstract: A palladium-catalyzed selective synthesis of cis- or trans-chloro-substituted-α-methylene-γ-butyrolactones from single substrate (propiolic acid) has been realized by controlling cis- or trans-chloropalladation. This method is highly effective for building C-Cl, C-O, and C-C bonds into a one-pot procedure because of its good atom and step efficiency.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dong
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Guo
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Yu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000480:Alkynes / Q000737:chemistry / Q000378:metabolism; D002384:Catalysis; D007783:Lactones / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry / Q000378:metabolism*; D011422:Propionates / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D007783:Lactones; D011422:Propionates; C014096:alpha-methylene gamma-butyrolactone; D010165:Palladium; D015107:4-Butyrolactone; C011537:propiolic acid