title: Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero.
abstract: Rapid growth in infancy considerably increases the risk of obesity and metabolic disorders in adulthood especially among neonates born small. To investigate the mechanism involved, we developed an animal model of undernourishment in utero by maternal caloric restriction, in which the Z scores of body weight at weaning (19.5 days) positively correlated with parameters of obesity, metabolic disorders, and remodeling of subcutaneous adipose tissue, such as numbers of macrophages in adipose tissue, the ratio of inflammatory M1 to anti-inflammatory M2 macrophages, estimated by gene expression of specific antigens, and the relative ratio of small adipocytes less than 30 μm in diameter, on a high-fat diet at 17 weeks of age. To our knowledge, this is the first report of a possible connection between infantile body weight and adipose tissue remodeling in obesity after undernourishment in utero.
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: Yukiko Kobayashi
authors.initials: YK
authors.lastname: Kohmura
authors.forename: Naohiro
authors.initials: N
authors.lastname: Kanayama
authors.forename: Keiko
authors.initials: K
authors.lastname: Muramatsu
authors.forename: Naoaki
authors.initials: N
authors.lastname: Tamura
authors.forename: Chizuko
authors.initials: C
authors.lastname: Yaguchi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Uchida
authors.forename: Kazunao
authors.initials: K
authors.lastname: Suzuki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sugihara
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Aoe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sasaki
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Suganami
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Itoh
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000502:physiology*; D005260:Female; D008297:Male; D044342:Malnutrition / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D050151:Subcutaneous Fat / Q000378:metabolism* / Q000473:pathology; D014886:Weaning
keywords: developmental origins of health and disease (DOHaD); high-fat diet; low birth weight; macrophage; obesity; pregnancy