title: The therapeutic effect of mitochondria-targeted antioxidant SkQ1 and Cistanche deserticola is associated with increased levels of tryptophan and kynurenine in the rat lens.
abstract: Supplementation of senescence-accelerated OXYS rats with the mitochondria-targeted antioxidant SkQ1 and with the powder from Cistanche deserticola results in the deceleration of the cataract development and even in the improvement of lens transparency. The therapeutic effect of these preparations correlates with a significant elevation of tryptophan and kynurenine levels in the lens. This finding is attributed to a deceleration of the tryptophan and kynurenine oxidation due to antioxidant-assisted reduction of oxidative stress in the lens.
authors.affiliation: International Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk State University, Novosibirsk, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Snytnikova
authors.forename: Yu P
authors.initials: YP
authors.lastname: Tsentalovich
authors.forename: N A
authors.initials: NA
authors.lastname: Stefanova
authors.forename: A Zh
authors.initials: AZh
authors.lastname: Fursova
authors.forename: R
authors.initials: R
authors.lastname: Kaptein
authors.forename: R Z
authors.initials: RZ
authors.lastname: Sagdeev
authors.forename: N G
authors.initials: NG
authors.lastname: Kolosova
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002386:Cataract / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control; D031671:Cistanche; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007737:Kynurenine / Q000378:metabolism*; D007908:Lens, Crystalline / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008928:Mitochondria / Q000187:drug effects*; D010971:Plastoquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome; D014364:Tryptophan / Q000378:metabolism*
chemical_list: C532038:10-(6'-plastoquinonyl)decyltriphenylphosphonium; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D007737:Kynurenine; D014364:Tryptophan; D010971:Plastoquinone