title: Antiviral and antibacterial polyurethanes of various modalities.
abstract: We have prepared and characterized a new polyurethane-based antimicrobial material, N,N-dodecyl,methyl-polyurethane (Quat-12-PU). It exhibits strong antiviral and antibacterial activities when coated (as an organic solution or an aqueous nanosuspension) onto surfaces and antibacterial activity when electrospun into nanofibers. Quat-12-PU surfaces are able to kill airborne Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria, as well as inactivate the enveloped influenza virus (but not the non-enveloped poliovirus).
authors.affiliation: Department of Bioengineering, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA. daewon.park@ucdenver.edu
authors.forename: Daewon
authors.initials: D
authors.lastname: Park
authors.forename: Alyssa M
authors.initials: AM
authors.lastname: Larson
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Klibanov
authors.forename: Yadong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D057139:Nanofibers / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D011140:Polyurethanes