title: IRB decision-making with imperfect knowledge: a framework for evidence-based research ethics review.
abstract: Here we describe the five steps of evidence-based practice as applied to research ethics review and apply these steps to three exemplar dilemmas: incentive payments in substance abuse research; informed consent for biobanking; and placebo-controlled trials involving pregnant women in order to demonstrate the potential of empirical data to inform and improve IRB decision-making.
authors.affiliation: Neiswanger Institute for Bioethics, Health Sciences Division, Loyola University Chicago, USA.
authors.forename: Emily E
authors.initials: EE
authors.lastname: Anderson
authors.forename: James M
authors.initials: JM
authors.lastname: DuBois
mesh_terms: D018070:Biological Specimen Banks / Q000941:ethics; D003657:Decision Making; D028744:Ethics Committees, Research / Q000331:legislation & jurisprudence; D055317:Evidence-Based Practice; D005260:Female; D006805:Human Experimentation / Q000941:ethics*; D006801:Humans; D007258:Informed Consent; D010919:Placebos; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000517:prevention & control; D011361:Professional Competence; D011640:Public Policy; D060926:Remuneration; D012107:Research Design; D019966:Substance-Related Disorders / Q000534:rehabilitation; D014019:Tissue Donors; D035501:Uncertainty; D014481:United States; D054556:Venous Thromboembolism / Q000517:prevention & control
chemical_list: D010919:Placebos