title: Hypoadiponectinemia: a useful marker of dyslipidemia in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  Adiponectin plays a role in obesity, lipid metabolism, and anti-inflammation. Women with polycystic ovary syndrome (PCOS) are also at risk for dyslipidemia. Therefore, we investigated the association between adiponectin levels and the lipid profile including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs) in women with PCOS and contemplated what role adiponectin might play in dyslipidemia with PCOS.
  
  
  METHODS
  We recruited 118 young Taiwanese women with PCOS. The women enrolled were not taking any medication and those with other systemic diseases of nonovarian origin, which could have affected the hypothalamic-pituitary-ovarian axis, were excluded. The serum lipid profile, metabolic and hormonal parameters, and adiponectin were measured. The lipid profile and adiponectin were analyzed and adjusted for age, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and sex hormone-binding globulin (SHBG).
  
  
  RESULTS
  In a simple linear regression, adiponectin was significantly inversely related to LDL-C and TGs, but positively related to HDL-C (all p < 0.001) after logarithmic transformation. In the multiple linear regression, adiponectin was significantly related to HDL-C (p < 0.001) independent of age, BMI, HOMA-IR, and SHBG after logarithmic transformation. Using a logistic regression, the odds ratio was 0.088 between the association of increased adiponectin and abnormal HDL-C (≤ 50 mg/dL).
  
  
  CONCLUSIONS
  We demonstrated that adiponectin is an independent biomarker that is positively and evidently related to HDL-C and TGs in women with PCOS. Hypoadiponectinemia may be a useful marker of dyslipidemia in women with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chih-Yuan
authors.initials: CY
authors.lastname: Chang
authors.forename: Mei-Jou
authors.initials: MJ
authors.lastname: Chen
authors.forename: Wei-Shiung
authors.initials: WS
authors.lastname: Yang
authors.forename: Ching-Ying
authors.initials: CY
authors.lastname: Yeh
authors.forename: Hong-Nerng
authors.initials: HN
authors.lastname: Ho
authors.forename: Shee-Uan
authors.initials: SU
authors.lastname: Chen
authors.forename: Yu-Shih
authors.initials: YS
authors.lastname: Yang
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000172:deficiency; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D016014:Linear Models; D016015:Logistic Models; D008661:Metabolism, Inborn Errors / Q000097:blood* / Q000150:complications; D008954:Models, Biological; D016017:Odds Ratio; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013624:Taiwan; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides