title: Assessing the maxillary sinus mucosa of rabbits in the presence of biodegradable implants.
abstract: In an attempt to improve the quality of life of patients with vitreous humor disease, ophthalmologists began offering steroid-eluting biodegradable implants to their patients. These implants can be used as an alternative treatment for CRS and this is why this experimental study was carried out on rabbit maxillary sinuses.
  
  
  OBJECTIVE
  This study aims to assess the histology of the mucosa of the maxillary sinuses of rabbits after the placement of a prednisolone-eluting biodegradable implant.
  
  
  METHODS
  Eighteen rabbits were randomly divided into two groups: group 1 - subjects had drug-eluting implants placed on their left maxillary sinuses; group 2 - subjects had non-drug-eluting implants placed on their left maxillary sinuses. The right maxillary sinuses served as the controls. After seven, 14, and 28 days three rabbits in each group were randomly picked to have their tissue inflammatory response assessed.
  
  
  RESULTS
  Levels of mucosal inflammation were not significantly different between the groups with and without drug-eluting implants and the control group, or when the groups with drug-eluting implants and non-drug-eluting implants were compared.
  
  
  CONCLUSIONS
  Signs of toxicity or mucosal inflammation were not observed in the maxillary sinuses of rabbits given prednisolone-eluting implants or non-drug-eluting implants.
authors.affiliation: Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes no. 3900, Ribeirão Preto - SP, Brazil. mcecilia@hcrp.fmrp.usp.br
authors.forename: André Coura
authors.initials: AC
authors.lastname: Perez
authors.forename: Armando da Silva
authors.initials: Ada S
authors.lastname: Cunha Junior
authors.forename: Sílvia Ligório
authors.initials: SL
authors.lastname: Fialho
authors.forename: Lívia Mara
authors.initials: LM
authors.lastname: Silva
authors.forename: João Vicente
authors.initials: JV
authors.lastname: Dorgam
authors.forename: Adriana de Andrade Batista
authors.initials: Ade A
authors.lastname: Murashima
authors.forename: Alfredo Ribeiro
authors.initials: AR
authors.lastname: Silva
authors.forename: Maria
authors.initials: M
authors.lastname: Rossato
authors.forename: Wilma Terezinha
authors.initials: WT
authors.lastname: Anselmo-Lima
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D008443:Maxillary Sinus / Q000473:pathology / Q000601:surgery*; D009297:Nasal Mucosa / Q000473:pathology / Q000601:surgery*; D011239:Prednisolone / Q000008:administration & dosage*; D011817:Rabbits; D011897:Random Allocation; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone