title: Within-person variation in the postprandial lipemic response of healthy adults.
abstract: BACKGROUND
  The response to dietary fat plays a key role in metabolic health. Although this can vary widely between individuals, variation within an individual and the associated contribution of phenotypic and genotypic factors to this variation are less defined.
  
  
  OBJECTIVE
  The objectives were to quantify within-person variation in triacylglycerol response by means of a novel variation score (S(v)) and to explore the phenotypic and genotypic factors associated with this score.
  
  
  METHODS
  Two consecutive 5-h oral-lipid-tolerance tests (OLTTs) were conducted in 51 healthy adults aged 18-60 y with a BMI (in kg/m²) of 18.5 to 49.8. Detailed body composition, physical function, biochemistry, and genotype data were gathered.
  
  
  RESULTS
  The postprandial triacylglycerol response profile did not differ (P = 0.64) across OLTTs for the group; nor did average concentrations of functional markers apolipoprotein C2 (P = 0.73) and apolipoprotein C3 (P = 0.74). S(v) was low in most (82%) of the adults and was significantly (P < 0.05) associated with age, fasting triacylglycerol, triacylglycerol AUC, and fasting nonessential fatty acids. Significant associations were also observed between S(v) and single nucleotide polymorphisms in 7 genes (APOA1, IL1α, IL1β, TLR4, TCF7L2, CCK1Rec, and STAT3) after correction for phenotypic differences.
  
  
  CONCLUSIONS
  This work showed that the within-person variability in postprandial lipemic response is low in most healthy adults. It also showed that variability in this response is associated with a defined set of phenotypic and genotypic characteristics.
authors.affiliation: Institute of Food and Health, University College Dublin Belfield, Dublin, Ireland. miriam.ryan@ucd.ie
authors.forename: Miriam F
authors.initials: MF
authors.lastname: Ryan
authors.forename: Colm M
authors.initials: CM
authors.lastname: O'Grada
authors.forename: Colm O
authors.initials: CO
authors.lastname: Grada
authors.forename: Ciara
authors.initials: C
authors.lastname: Morris
authors.forename: Ricardo
authors.initials: R
authors.lastname: Segurado
authors.forename: Marianne C
authors.initials: MC
authors.lastname: Walsh
authors.forename: Eileen R
authors.initials: ER
authors.lastname: Gibney
authors.forename: Lorraine
authors.initials: L
authors.lastname: Brennan
authors.forename: Helen M
authors.initials: HM
authors.lastname: Roche
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Gibney
mesh_terms: D000293:Adolescent; D000328:Adult; D016632:Apolipoprotein A-I / Q000235:genetics / Q000378:metabolism; D015331:Cohort Studies; D059305:Diet, High-Fat / Q000009:adverse effects*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D007378:Interleukins / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D007494:Ireland; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D019518:Postprandial Period; D054389:Receptors, CCR1 / Q000235:genetics / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000378:metabolism; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; C515300:CCR1 protein, human; D007378:Interleukins; D054389:Receptors, CCR1; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C544894:TCF7L2 protein, human; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D058118:Transcription Factor 7-Like 2 Protein