title: Cytomegalovirus retinitis following intravitreal triamcinolone acetonide in a patient with chronic uveitis on systemic immunosuppression.
abstract: OBJECTIVE
  To report a case of cytomegalovirus (CMV) retinitis in an HIV-negative, iatrogenically immunosuppressed patient with chronic uveitis following intravitreal triamcinolone acetonide (IVTA).
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  A 56-year-old female with chronic idiopathic panuveitis on azathioprine received a single 4-mg IVTA injection for macular edema and presented after 6 months with severe retinitis.
  
  
  RESULTS
  CMV was confirmed by polymerase chain reaction of vitreous fluid. The retinitis responded well to intravitreal ganciclovir, but she developed a rhegmatogenous retinal detachment and underwent vitrectomy with silicone oil tamponade.
  
  
  CONCLUSIONS
  Sight-threatening CMV retinitis may develop in HIV-negative, immunosuppressed individuals after IVTA. Regular fundoscopy for up to 9 months after IVTA is recommended.
authors.affiliation: Department of Ophthalmology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Anthony Grant
authors.initials: AG
authors.lastname: Zaborowski
mesh_terms: D002908:Chronic Disease; D017726:Cytomegalovirus Retinitis / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000379:methods*; D058449:Intravitreal Injections; D008875:Middle Aged; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000009:adverse effects*; D014605:Uveitis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide