title: Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream.
abstract: The accessory olfactory bulb (AOB) is a critical olfactory structure that has been implicated in mediating social behavior. It receives input from the vomeronasal organ and projects to targets in the amygdaloid complex. Its anterior and posterior components (aAOB and pAOB) display molecular, connectional and functional segregation in processing reproductive and defensive and aggressive behaviors, respectively. We observed a dichotomy in the development of the projection neurons of the aAOB and pAOB in mice. We found that they had distinct sites of origin and that different regulatory molecules were required for their specification and migration. aAOB neurons arose locally in the rostral telencephalon, similar to main olfactory bulb neurons. In contrast, pAOB neurons arose caudally, from the neuroepithelium of the diencephalic-telencephalic boundary, from which they migrated rostrally to reach their destination. This unusual origin and migration is conserved in Xenopus, providing an insight into the origin of a key component of this system in evolution.
authors.affiliation: Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Huilgol
authors.forename: Susan
authors.initials: S
authors.lastname: Udin
authors.forename: Tomomi
authors.initials: T
authors.lastname: Shimogori
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Saha
authors.forename: Achira
authors.initials: A
authors.lastname: Roy
authors.forename: Shinichi
authors.initials: S
authors.lastname: Aizawa
authors.forename: Robert F
authors.initials: RF
authors.lastname: Hevner
authors.forename: Gundela
authors.initials: G
authors.lastname: Meyer
authors.forename: Toshio
authors.initials: T
authors.lastname: Ohshima
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Pleasure
authors.forename: Yangu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Shubha
authors.initials: S
authors.lastname: Tole
mesh_terms: D000344:Afferent Pathways / Q000502:physiology*; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D005075:Biological Evolution; D001973:Bromodeoxyuridine / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D051360:Cyclin-Dependent Kinase 5 / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004027:Diencephalon / Q000166:cytology / Q000502:physiology; D018274:Electroporation / Q000379:methods; D004622:Embryo, Mammalian; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D008164:Luminescent Proteins / Q000235:genetics; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008845:Microinjections / Q000379:methods; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D009687:Nuclear Proteins; D009830:Olfactory Bulb / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D009865:Oocytes; D009924:Organ Culture Techniques; D011247:Pregnancy; D013687:Telencephalon / Q000166:cytology / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins; D019147:Vomeronasal Organ / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D014981:Xenopus
chemical_list: D004268:DNA-Binding Proteins; D008164:Luminescent Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C000606368:Trp73 protein, mouse; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins; D051360:Cyclin-Dependent Kinase 5; D001973:Bromodeoxyuridine