title: [Aerosolized iloprost therapy for pulmonary hypertensive crisis in 4 patients with idiopathic pulmonary arterial hypertension].
abstract: OBJECTIVE
  To summary the efficacy and safety of aerosolized iloprost in patients with pulmonary hypertensive crisis.
  
  
  METHODS
  On the basis of conventional therapy, aerosolized iloprost (10 µg per time for 10 - 15 min in 2 hours interval, 8 times per day) was administered to four patients with idiopathic pulmonary arterial hypertension and pulmonary hypertensive crisis. Blood pressure, heart rate, systemic artery oxygen saturation, systolic pulmonary arterial pressure (sPAP) measured by echocardiography and the adverse events were analyzed.
  
  
  RESULTS
  After aerosolized iloprost therapy, sPAP was significantly decreased and systemic artery oxygen saturation was improved. Adverse events (nausea, vomiting, diarrhea, dry cough) were observed in two patients, and the iloprost use was stopped in one patient due to severe vomiting and diarrhea.
  
  
  CONCLUSIONS
  Aerosolized iloprost could significantly reduce the sPAP and improve the systemic artery oxygen saturation in patients with pulmonary hypertension crisis.
authors.affiliation: The Affiliated Tongren Hospital of the Capital Medical University, Beijing, China.
authors.forename: Ke-wu
authors.initials: KW
authors.lastname: Deng
authors.forename: Yu-jie
authors.initials: YJ
authors.lastname: Zhou
authors.forename: Xi-qi
authors.initials: XQ
authors.lastname: Xu
authors.forename: Ming-ying
authors.initials: MY
authors.lastname: Wu
authors.forename: Guo-hong
authors.initials: GH
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Bian
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Chun-bo
authors.initials: CB
authors.lastname: Wang
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001794:Blood Pressure; D002648:Child; D065627:Familial Primary Pulmonary Hypertension; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D016285:Iloprost / Q000008:administration & dosage* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D016285:Iloprost