title: RanBPM, a scaffolding protein for gametogenesis.
abstract: RanBPM is a multimodular scaffold protein that interacts with a great variety of molecules including nuclear, cytoplasmic, and membrane proteins. By building multiprotein complexes, RanBPM is thought to regulate various signaling pathways, especially in the immune and nervous system. However, the diversity of these interactions does not facilitate the identification of its precise mechanism of action, and therefore the physiological role of RanBPM still remains unclear. Recently, RanBPM has been shown to be critical for the fertility of both genders in mouse. Although mechanistically it is still unclear how RanBPM affects gametogenesis, the data collected so far suggest that it is a key player in this process. Here, we examine the RanBPM sterility phenotype in the context of other genetic mutations affecting mouse gametogenesis to investigate whether this scaffold protein affects the function of other known proteins whose deficiency results in similar sterility phenotypes.
authors.affiliation: Neural Development Section, Mouse Cancer Genetics Program, Center for Cancer Research, NCI, Frederick, Maryland, USA. puverels@gmail.com
authors.forename: Sandrine
authors.initials: S
authors.lastname: Puverel
authors.forename: Lino
authors.initials: L
authors.lastname: Tessarollo
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000172:deficiency / Q000378:metabolism*; D000818:Animals; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000172:deficiency / Q000378:metabolism*; D005718:Gametogenesis; D005854:Germ Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008540:Meiosis; D009687:Nuclear Proteins / Q000737:chemistry / Q000172:deficiency / Q000378:metabolism*; D010641:Phenotype; D012098:Reproduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D003598:Cytoskeletal Proteins; D009687:Nuclear Proteins; C116005:Ran binding protein 9