title: Interrupted oxygen pre-breathing and decompression outcomes in swine.
abstract: BACKGROUND
  Rescue from a disabled submarine may result in substantial risk for severe decompression sickness (DCS) among survivors. Oxygen prebreathe (OPB) before rapid decompression has been shown to significantly reduce risk or delay onset for severe DCS in animals. However, the duration of this benefit remains unknown and might even be lost if a delay between the prebreathe period to initiation of recompression therapy allows for nitrogen reaccumulation.
  
  
  METHODS
  We hypothesized that the benefit of OPB would be lost following subsequent periods of air interruption in a 70-kg swine saturation model. Following OPB of 45 or 60 min with varying periods (30, 45, 60 min) of air interruption, 61 swine exposed to 2.7 ATA for 22 h were rapidly decompressed. Swine without OPB served as negative controls and swine treated with 45 min of OPB without air interruption served as positive controls.
  
  
  RESULTS
  Comparing experimental groups for Type II DCS incidence showed OPB120/60 being the only experimental group (11%) statistically different than the negative control group OPB0 (80%). Log rank tests comparing Type II DCS free survival only showed statistically significant differences for OPB45/60 compared to positive control group OPB45, while, more importantly, demonstrating a significant difference for OPB120/60 compared to that approximated for OPB45, indicating a significant reversal of the air interruption effects with longer OPB on Type II DCS disease free survival.
  
  
  CONCLUSIONS
  Based on these findings we concluded that the protective effects of OPB against severe DCS are reduced with increasing periods of air interruption.
authors.affiliation: Fort Belvoir Community Hospital, Family Medicine Residency, Fort Belvoir, VA, USA.
authors.forename: Seth Y
authors.initials: SY
authors.lastname: Flagg
authors.forename: David P
authors.initials: DP
authors.lastname: Regis
authors.forename: Kyle
authors.initials: K
authors.lastname: Petersen
authors.forename: Richard T
authors.initials: RT
authors.lastname: Mahon
mesh_terms: D000818:Animals; D003664:Decompression / Q000379:methods*; D003665:Decompression Sickness / Q000401:mortality / Q000517:prevention & control*; D018572:Disease-Free Survival; D008297:Male; D010100:Oxygen / Q000008:administration & dosage; D013366:Submarine Medicine; D013552:Swine; D013997:Time Factors
chemical_list: D010100:Oxygen