title: AZA Wildlife Contraception Center programme for wild felids and canids.
abstract: North American zoos began using melengestrol acetate (MGA) implants to control reproduction in wild felids in the mid-1970s. Research linking MGA and other progestin-based contraceptives to uterine and mammary pathology in canids as well as felids resulted in a shift to GnRH agonist implants (Suprelorin(®): deslorelin, Peptech Animal Health, Australia). However, a recent study revealed an association between Suprelorin(®) and uterine pathology in canids, but that pathology was not found in canids treated with oral megestrol acetate (MA) for 2 weeks around the time of implant insertion to prevent the initial agonist stimulation phase. Thus, the AZA Wildlife Contraception Center (WCC) currently recommends Suprelorin(®) plus the 2-week MA regimen for wild canids and felids. WCC research is now focusing on factors affecting Suprelorin(®) reversibility.
authors.affiliation: Saint Louis Zoo, Saint Louis, MO, USA. asa@stlzoo.org
authors.forename: C
authors.initials: C
authors.lastname: Asa
authors.forename: S
authors.initials: S
authors.lastname: Boutelle
authors.forename: K
authors.initials: K
authors.lastname: Bauman
mesh_terms: D000818:Animals; D000835:Animals, Wild; D000836:Animals, Zoo; D046028:Canidae / Q000502:physiology*; D003270:Contraceptive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004343:Drug Implants; D056727:Endangered Species; D045989:Felidae / Q000502:physiology*; D005260:Female; D019290:Megestrol Acetate / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D017410:Practice Guidelines as Topic; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D003270:Contraceptive Agents; D004343:Drug Implants; D017329:Triptorelin Pamoate; D019290:Megestrol Acetate; C066438:deslorelin