title: Physical exercise down-regulated locomotor side effects induced by haloperidol treatment in Wistar rats.
abstract: Extra-pyramidal symptoms (EPS) such as akinesia, dystonia, gait alteration and tremors are observed when dopamine D2-receptors are blocked by pharmacological agents such as haloperidol. These alterations produce a Parkinson disease-like state (PLS). Physical exercise has been proven to improve gait and locomotor symptoms in Parkinson's disease; we sought to elucidate the effects of physical exercise on PLS induced by chronic administration of haloperidol in rats. We used 48 rats distributed into four groups: Control, Exercise, Haloperidol, and Hal+Exe. All the animals received a daily injection of saline or haloperidol for 30 days, and the exercise groups underwent a daily 30-minute exercise protocol for 20 days. The animals were subjected to the ink-paw test, bar test and open-field test throughout the training period. The haloperidol-induced akinesia increased throughout the days of injections, but exercise was shown to alleviate it. The assessment showed shortened stride length and increased stance width with the use of haloperidol, which were significantly alleviated by exercise. These results indicate that exercise could be an interesting approach towards reducing unwanted EPS caused by haloperidol.
authors.affiliation: Laboratório de Biologia Celular e Tecidual, Departamento de Ciências Morfofisiológicas, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil. pedropoa@gmail.com
authors.forename: Pedro Porto Alegre
authors.initials: PP
authors.lastname: Baptista
authors.forename: Priscylla Nunes
authors.initials: PN
authors.lastname: de Senna
authors.forename: Mariana Fontoura
authors.initials: MF
authors.lastname: Paim
authors.forename: Lisiani
authors.initials: L
authors.lastname: Saur
authors.forename: Martina
authors.initials: M
authors.lastname: Blank
authors.forename: Patricia
authors.initials: P
authors.lastname: do Nascimento
authors.forename: Jocemar
authors.initials: J
authors.lastname: Ilha
authors.forename: Mônica Ryff Moreira
authors.initials: MR
authors.lastname: Vianna
authors.forename: Régis Gemerasca
authors.initials: RG
authors.lastname: Mestriner
authors.forename: Matilde
authors.initials: M
authors.lastname: Achaval
authors.forename: Léder Leal
authors.initials: LL
authors.lastname: Xavier
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D018492:Dopamine Antagonists / Q000009:adverse effects*; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D006220:Haloperidol / Q000009:adverse effects*; D007794:Lameness, Animal / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy*; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018492:Dopamine Antagonists; D006220:Haloperidol