title: Pancreas transplantation and reversal of diabetic nephropathy lesions.
abstract: Pancreas transplantation is the only available treatment that has restored long-term (10 or more years) normoglycemia without the risks of severe hypoglycemia, allowing testing of the reversibility of diabetic nephropathy lesions. The authors studied renal structure before and 5 and 10 years after pancreas transplantation in nonuremic patients with long-term type 1 diabetes, with established diabetic nephropathy lesions at baseline. Diabetic glomerular lesions were not significantly changed at 5 years but were dramatically improved after 10 years, with most patients' glomerular structure returning to normal at the 10-year follow-up. These studies also showed that tubulointerstitial remodeling was also possible.
authors.affiliation: Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55454, USA. mauer002@umn.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Mauer
authors.forename: Paola
authors.initials: P
authors.lastname: Fioretto
mesh_terms: D000328:Adult; D001706:Biopsy; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000601:surgery; D003928:Diabetic Nephropathies / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006085:Graft Survival; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D016035:Pancreas Transplantation / Q000379:methods*; D013995:Time; D016896:Treatment Outcome
chemical_list: D006442:Glycated Hemoglobin