title: Combined use of ionic liquid and β-CD for enantioseparation of 12 pharmaceuticals using CE.
abstract: In this study, the enantioseparation of zopiclone, repaglinide, chlorphenamine maleate, brompheniramine maleate, dioxopromethazine hydrochloride, promethazine hydrochloride, liarozole, carvedilol, homatropine hydrobromide, homatropine methylbromide, venlafaxine, and sibutramine hydrochloride has been investigated using β-CD in combination with a chiral ionic liquid (IL), 1-ethyl-3-methylimidazolium-L-lactate. The influence of the type of IL and its concentration, BGE pH, and chain length of the IL cations on the resolution are discussed. Finally, the proposed method was successfully applied for the chiral impurity determination of eszopiclone in pharmaceutical tablets after validation with respect to accuracy and precision, linearity range, selectivity, repeatability, LOD and LOQ. It is assessed that the chiral impurity determination in the commercial tables is fewer than 0.1%.
authors.affiliation: Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, P R China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Zuo
authors.forename: Heng
authors.initials: H
authors.lastname: Meng
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Jiang
authors.forename: Shuying
authors.initials: S
authors.lastname: Xu
authors.forename: Xingjie
authors.initials: X
authors.lastname: Guo
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D052578:Ionic Liquids / Q000737:chemistry; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003505:Cyclodextrins; D052578:Ionic Liquids; D004364:Pharmaceutical Preparations