title: Efficacy of a novel moist cool air device in office workers with dry eye disease.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of new moist cool air device (MCAD) for ocular symptoms, tear film stability and ocular surface status in office workers with dry eye disease (DED).
  
  
  METHODS
  In this prospective single-centre clinical trial, 40 eyes of 20 patients with DED were recruited and randomly divided into two groups (group with MCAD exposure and group without MCAD). All subjects are visual display terminals (VDTs) workers spending at least 4 h/day in front of VDTs. Patients using MCAD underwent moist air applications for 4 h/day for a total of five working weekdays during VDT works at their offices. The other group of patients performed their VDT work without moist cool air device exposure. The change in symptoms of ocular surface (OS) dryness, fatigue and discomfort was evaluated using visual analogue scale (VAS) scores. Changes in visual function, tear functions and ocular surface status were evaluated using best-corrected visual acuity (BCVA), the functional visual acuity (FVA) test, blink rate, BUT measurements, strip meniscometry (SM), tear evaporation rate, fluorescein staining and rose bengal staining scores. Tear film lipid layer interferometry was also performed to assess the status of the lipid layer over the tear film. In addition, adverse events were recorded.
  
  
  RESULTS
  In group with MCAD, symptoms of OS dryness during VDTs work, and FVA and BUT were significantly improved. SM and tear evaporation rate were significantly improved. There were no statistically significant differences on lipid layer stability and corneal staining scores in both groups. Blink rate was significantly increased in group without MCAD. No adverse events were reported during this trial.
  
  
  CONCLUSIONS
  Moist cool air device use provided symptomatic relief of ocular dryness and improvement on tear stability in office workers with DED. This new device seems to be a safe and promising alternative in the treatment of DED.
authors.affiliation: Department of Ophthalmology, School of Medicine, Keio University, Tokyo, JapanMinami-Aoyama Eye Clinic, Tokyo, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hirayama
authors.forename: Dogru
authors.initials: D
authors.lastname: Murat
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Takashi
authors.initials: T
authors.lastname: Kojima
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawakita
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000328:Adult; D000388:Air; D001248:Asthenopia / Q000503:physiopathology / Q000628:therapy*; D001767:Blinking / Q000502:physiology; D016288:Computer Terminals; D015352:Dry Eye Syndromes / Q000503:physiopathology / Q000628:therapy*; D004867:Equipment Design; D005260:Female; D006801:Humans; D006813:Humidity; D007368:Interferometry; D008297:Male; D009330:Nebulizers and Vaporizers; D011446:Prospective Studies; D013666:Tears / Q000502:physiology; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
keywords: dry eye; new moist air device; office worker; visual terminal displays