title: Controllable release from magnetoliposomes by magnetic stimulation and thermal stimulation.
abstract: Liposomes with superparamagnetic iron oxide nanoparticles embedded in membrane were prepared by the supercritical carbon dioxide (scCO(2)) method. The cargos can be released from liposomes by both triggered agents, temperature and alternating current electromagnetic field (AMF). The release mechanism was explained from the view of microstructure change investigated by fluorescence probe method. The contents could be repetitively released from liposomes controlled by switching on and off the AMF. The results indicated that the release from the liposomes was due to the magnetocaloric effect resulting in the liposome phase transition and the magnetic-impelled motions leading to the improved bilayer permeability, rather than the destruction of the liposome structure.
authors.affiliation: School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Qiu
authors.forename: Xueqin
authors.initials: X
authors.lastname: An
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D013696:Temperature; D050781:Transcranial Magnetic Stimulation
chemical_list: D005290:Ferric Compounds; D008081:Liposomes; D058185:Magnetite Nanoparticles; D002245:Carbon Dioxide; C000499:ferric oxide