title: Role of microRNAs in breast cancer.
abstract: MicroRNAs (miRNAs) are a class of post-transcriptional gene regulators with critical functions in normal cellular processes as well as disease processes. They are small molecules with 18~23 nucleotides in length. Since their early discovery in 1993, a large number of miRNAs have been characterized and analyzed to understand their pivotal role and their impact in a myriad of biological processes. Substantial research on miRNA highlights the involvement of these tiny RNAs in the etiopathogenesis of a variety of human diseases such as cancer, neuro-degenerative disorders, diabetes, cardiac hypertrophy and respiratory diseases. In this review, we update on recent advances of the emerging role of miRNAs in breast cancer and their clinical implications.
authors.affiliation: Cancer Institute, University of Mississippi Medical Center, Jackson, MS USA.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Singh
authors.forename: Yin-Yuan
authors.initials: YY
authors.lastname: Mo
mesh_terms: D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D014411:Neoplastic Stem Cells / Q000378:metabolism
chemical_list: D035683:MicroRNAs
keywords: breast cancer; chemoresistance; microRNAs