title: Feline degenerative joint disease: a genomic and proteomic approach.
abstract: The underlying disease mechanisms for feline degenerative joint disease (DJD) are mostly unidentified. Today, most of what is published on mammalian arthritis is based on human clinical findings or on mammalian models of human arthritis. However, DJD is a common occurrence in the millions of domestic felines worldwide. To get a better understanding of the changes in biological pathways that are associated with feline DJD, this study employed a custom-designed feline GeneChip, and the institution's unique access to large sample populations to investigate genes and proteins from whole blood and serum that may be up- or down-regulated in DJD cats. The GeneChip results centered around three main pathways that were affected in DJD cats: immune function, apoptosis and oxidative phosphorylation. By identifying these key disease-associated pathways it will then be possible to better understand disease pathogenesis and diagnose it more easily, and to better target it with pharmaceutical and nutritional intervention.
authors.affiliation: Hill's Pet Nutrition Center, Topeka, KS, USA.
authors.forename: Xiangming
authors.initials: X
authors.lastname: Gao
authors.forename: Junyu
authors.initials: J
authors.lastname: Lee
authors.forename: Sukhaswami
authors.initials: S
authors.lastname: Malladi
authors.forename: Lynda
authors.initials: L
authors.lastname: Melendez
authors.forename: B Duncan X
authors.initials: BD
authors.lastname: Lascelles
authors.forename: Samer
authors.initials: S
authors.lastname: Al-Murrani
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D002415:Cats; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D023281:Genomics; D010003:Osteoarthritis / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D040901:Proteomics