title: Role of mast cells in gynecological neoplasms.
abstract: Mast cells are of paramount importance in allergic reactions, pathogen immune responses during infection, and angiogenesis, as well as innate and adaptive immune regulation. Beyond all these roles, mast cells are now increasingly being recognized as modulators of tumor biology and fate. Notwithstanding mounting evidence of mast cell accumulation in tumors, their exact role in tumorigenesis and tumor progression is still incompletely understood. Although some evidence suggests that mast cells can promote tumorigenesis, there are some clinical sets as well as experimental tumor models in which mast cells seem to have functions that favor the host. This article focuses on the significant roles of mast cells in the mechanism, early diagnosis, differential diagnosis and evaluation of prognosis of gynecological neoplasms, with particular emphasis on the capacity of these cells to stimulate tumor growth by promoting angiogenesis, and highlight recent findings on the integral roles of mast cells in gynecological neoplasm growth, such as cervical and breast cancer. Information to be presented suggests that mast cells may become useful tools for future anticancer therapies.
authors.affiliation: No. 109 Xueyuan Xi Road, Department of Obstetrics and Gynecology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325027, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Jiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Hua
authors.forename: Qi
authors.initials: Q
authors.lastname: Shen
authors.forename: Shendi
authors.initials: S
authors.lastname: Ding
authors.forename: Wenxiao
authors.initials: W
authors.lastname: Jiang
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zhang
authors.forename: Xueqiong
authors.initials: X
authors.lastname: Zhu
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000473:pathology; D053818:Chymases / Q000378:metabolism; D005260:Female; D005833:Genital Neoplasms, Female / Q000276:immunology* / Q000473:pathology; D031901:Gestational Trophoblastic Disease / Q000276:immunology; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis; D008407:Mast Cells / Q000276:immunology* / Q000502:physiology; D011247:Pregnancy; D002583:Uterine Cervical Neoplasms / Q000209:etiology; D014594:Uterine Neoplasms / Q000175:diagnosis; D014846:Vulvar Neoplasms / Q000276:immunology
chemical_list: C509226:CMA1 protein, human; D053818:Chymases