title: A two-photon fluorescent probe for amyloid-β plaques in living mice.
abstract: We report a small molecule two-photon probe (SAD1) that shows a significant TP action cross section (170 GM), binds to Aβ plaques specifically, readily enters the brain through the BBB, and can directly 3D monitor the individual Aβ plaque in living transgenic mice at more than 380 μm depths.
authors.affiliation: Division of Energy Systems Research, Ajou University, Suwon, 443-749, Korea.
authors.forename: Cheol Ho
authors.initials: CH
authors.lastname: Heo
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Kim
authors.forename: Hyung Joong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Baik
authors.forename: Hyundong
authors.initials: H
authors.lastname: Song
authors.forename: Yong Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Jeewoo
authors.initials: J
authors.lastname: Lee
authors.forename: Inhee
authors.initials: I
authors.lastname: Mook-jung
authors.forename: Hwan Myung
authors.initials: HM
authors.lastname: Kim
mesh_terms: D015081:2-Naphthylamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D052160:Benzothiazoles / Q000737:chemistry* / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism*; D021621:Imaging, Three-Dimensional; D051379:Mice; D008970:Molecular Weight; D009281:Naphthalenes / Q000737:chemistry* / Q000378:metabolism*; D017785:Photons; D058225:Plaque, Amyloid / Q000378:metabolism* / Q000473:pathology; D012995:Solubility
chemical_list: C582777:6-(6-hydroxybenzo(d)thiazol-2'-yl)-2-(N,N-dimethylamino)naphthalene; D052160:Benzothiazoles; D005456:Fluorescent Dyes; D009281:Naphthalenes; C031721:naphthalene; D015081:2-Naphthylamine