title: Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments.
abstract: The protein NLRP3 has emerged as a central regulator in the inflammatory process, being implicated directly in hereditary cryopyrinopathies, and indirectly in diseases such as gout, Type 2 diabetes and atherosclerosis. NLRP3 is an important regulator of caspase-1, the enzyme that processes the immature form of IL-1β into the active protein. The control of NLRP3 has therefore become a focus of research with evidence for redox regulation, ubiquitination and regulation by miRNA-223, kinases and calcium all emerging as controllers of NLRP3. As our knowledge expands the prospect for precise pharmacological targeting of NLRP3 will improve and could lead to substantial clinical utility.
authors.affiliation: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
authors.forename: Moritz
authors.initials: M
authors.lastname: Haneklaus
authors.forename: Luke A J
authors.initials: LA
authors.lastname: O'Neill
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Coll
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D056587:Cryopyrin-Associated Periodic Syndromes / Q000235:genetics* / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D056747:Immunomodulation; D058847:Inflammasomes / Q000276:immunology / Q000378:metabolism*; D007249:Inflammation / Q000235:genetics; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology*; D058990:Molecular Targeted Therapy; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011110:Polymorphism, Genetic
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D035683:MicroRNAs; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C525067:MIR223, human; C453881:NLRP3 protein, human