title: [Use of intravenous humana immunoglobulin in rheumatic diseases].
abstract: BACKGROUND
  Preparations of intravenous immunoglobulin (IVIG) are used as treatment in different diseases such primary and secondary immunodeficiencies, autoimmune diseases, systemic inflammatory diseases, infectious diseases and allergic diseases among others.
  
  
  OBJECTIVE
  to present 13 of our cases with the use of IVIG in different rheumatic diseases.
  
  
  METHODS
  we retrospectively studied 13 patients (10 women and 3 men), mean age 29 years with different rheumatic diseases, that underwent conventional treatments without positive response. They received IVIG pulses, trying to improve or induce remission of their previous clinical situation. 6/13 patients met criteria for systemic lupus erythematosus (SLE), 2/13 had primary antiphospholipid syndrome (APL)one had polydermatomyositis (PDM), 1 juvenile arthritis, 1 panarteritis nodosa (cutaneous PAN), one Evans syndrome, and one with autoimmune uveitis.
  
  
  RESULTS
  7 of them had a positive response to therapy with IGEV evaluated by clinical and biochemical parameters. They remained with conventional treatments. One patient received a new IG EV pulse after 24 months, because of panniculitis reactivation. Clinical and biochemical response was poor in 4 of them, and 2 patients died.
  
  
  CONCLUSIONS
  IVIg may be usefull in autoimmune rheumatic diseases when conventional therapies have failed. The therapeutic success is also limited. Only the 55 percent of our patients had a positive clinical response.
authors.affiliation: Servicio de Reumatologia, UHMI 1, Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba Santa Rosa 1564, 5000 Córdoba Argentina. edemussano@yahoo.com.ar
authors.forename: Eduardo D
authors.initials: ED
authors.lastname: Mussano
authors.forename: Laura B
authors.initials: LB
authors.lastname: Onetti
authors.forename: Isaac I
authors.initials: II
authors.lastname: Cadile
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Onetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012216:Rheumatic Diseases / Q000276:immunology / Q000628:therapy*; D055815:Young Adult
chemical_list: D016756:Immunoglobulins, Intravenous