title: Nesfatin-1: its role in the diagnosis and treatment of obesity and some psychiatric disorders.
abstract: We discovered a new anorexigenic protein, nesfatin/nucleobindin-2 (NUCB2), which includes an EF-hand, calcium-binding motif. Nesfatin/NUCB2 is converted to nesfatin-1, which may be a physiologically active form in the body. Centrally and systemically administered nesfatin-1 inhibits appetite and body weight gain in rodents. The mid-segment of nesfatin-1 appears to be important in the inhibition of food intake. Intranasal administration of the mid-segment inhibits appetite. Nesfatin-1 may also be involved in the regulation of gastrointestinal function and insulin secretion. We have summarized the recent progress in the research of nesfatin-1.
authors.affiliation: Department of Health and Nutrition, Faculty of Health and Welfare, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan. shimizu-h@takasaki-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001066:Appetite; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D005247:Feeding Behavior; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis* / Q000378:metabolism / Q000523:psychology / Q000628:therapy*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*; D000080866:Nucleobindins; D009765:Obesity / Q000175:diagnosis* / Q000378:metabolism / Q000523:psychology / Q000628:therapy*
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins