title: Pseudolarenone, an unusual nortriterpenoid lactone with a fused 5/11/5/6/5 ring system featuring an unprecedented bicyclo[8.2.1]tridecane core from Pseudolarix amabilis.
abstract: A phytochemical investigation of the cone of Pseudolarix amabilis led to the isolation of pseudolarenone (), a structurally novel pentacyclic (5/11/5/6/5) nortriterpenoid lactone with an unprecedented carbon skeleton featuring a unique bicyclo[8.2.1]tridecane core. Its structure and absolute configurations were elucidated by spectroscopic analysis and single crystal X-ray diffraction (CuK(α)).
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: De-Yun
authors.initials: DY
authors.lastname: Kong
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Ka-Li
authors.initials: KL
authors.lastname: Fu
authors.forename: Rong-Cai
authors.initials: RC
authors.lastname: Yue
authors.forename: Zhu-Zhen
authors.initials: ZZ
authors.lastname: Han
authors.forename: Hu
authors.initials: H
authors.lastname: Yuan
authors.forename: Qing-Xin
authors.initials: QX
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Shan
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Li
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000378:metabolism; D028201:Pinaceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D000473:Alkanes; D001643:Bridged Bicyclo Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; D007783:Lactones; D013141:Spiro Compounds; D014315:Triterpenes; D009569:Nitric Oxide; C094074:tridecane