title: Methoxyethylammonium monosubstituted β-cyclodextrin as the chiral selector for enantioseparation in capillary electrophoresis.
abstract: Methoxyethylamine monosubstituted β-cyclodextrin, mono-6(A)-(2-methoxyethyl-1-ammonium)-6(A)-β-cyclodextrin chloride (MEtAMCD), is synthesized and analytically characterized. Bearing a methoxy group in cyclodextrin rim, MEtAMCD exhibits outstanding enantioselectivities toward ampholytic and acidic racemates in capillary electrophoresis. Driven by inclusion complexation, electrostatic interactions and/or hydrogen bonding, the enantioseparation of MEtAMCD is found to be strongly dependent on various separation parameters including buffer pH, cyclodextrin concentration, applied voltage, separation temperature and organic solvent additives. MEtAMCD demonstrates as a versatile cationic chiral selector for the studied 26 acidic and ampholytic enantiomers.
authors.affiliation: Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing 210094, China.
authors.forename: Shuye
authors.initials: S
authors.lastname: Wang
authors.forename: Yun
authors.initials: Y
authors.lastname: Dai
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Jian
authors.initials: J
authors.lastname: Tang
authors.forename: Weihua
authors.initials: W
authors.lastname: Tang
mesh_terms: D019075:Electrophoresis, Capillary / Q000379:methods*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D055672:Static Electricity; D013237:Stereoisomerism; D053719:Tandem Mass Spectrometry; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D047392:beta-Cyclodextrins; C031215:betadex