title: Pharmacokinetic analysis of oral doxycycline in rhesus macaques.
abstract: BACKGROUND
  Following administration of an antibiotic, the concentration in blood changes over time and is dependent on the type of antibiotic, the route and species of the individual. The most relevant pharmacodynamic property of a bacteriostatic antibiotic such as doxycycline is the minimum inhibitory concentration (MIC), whereas pharmacokinetics may include rates of absorption and elimination from blood.
  
  
  METHODS
  We determined serum concentrations of doxycycline following administration of 5 mg/kg in two macaques.
  
  
  RESULTS
  The area under the concentration-time curve over 24 hours (AUC0-24 ) following two doses was extrapolated from the curve over 12 hours following a single dose, with the purpose of calculating the AUC0-24 :MIC.
  
  
  CONCLUSIONS
  Other than a somewhat faster rate of elimination, the PK-PD values for doxycycline in macaques appears similar to those determined for humans. This information will be valuable for treating disease in macaques and for research in bacterial infection models that use macaques.
authors.affiliation: Division of Bacteriology & Parasitology, Tulane National Primate Research Center, Covington, LA 70433, USA. members@tulane.edu
authors.forename: Monica E
authors.initials: ME
authors.lastname: Embers
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Hasenkampf
authors.forename: Dale G
authors.initials: DG
authors.lastname: Embers
authors.forename: Lara A
authors.initials: LA
authors.lastname: Doyle
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001424:Bacterial Infections / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008253:Macaca mulatta / Q000378:metabolism*; D008297:Male; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline