title: In-a-dish: induced pluripotent stem cells as a novel model for human diseases.
abstract: Human pluripotent stem cells bring promise in regenerative medicine due to their self-renewing ability and the potential to become any cell type in the body. Moreover, pluripotent stem cells can produce specialized cell types that are affected in certain diseases, generating a new way to study cellular and molecular mechanisms involved in the disease pathology under the controlled conditions of a scientific laboratory. Thus, induced pluripotent stem cells (iPSC) are already being used to gain insights into the biological mechanisms of several human disorders. Here we review the use of iPSC as a novel tool for disease modeling in the lab.
authors.affiliation: Stem Cell Laboratory, Surgery Department, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil. patriciacbbbraga@usp.br
authors.forename: P C B
authors.initials: PC
authors.lastname: Beltrão-Braga
authors.forename: G C
authors.initials: GC
authors.lastname: Pignatari
authors.forename: F B
authors.initials: FB
authors.lastname: Russo
authors.forename: I R
authors.initials: IR
authors.lastname: Fernandes
authors.forename: A R
authors.initials: AR
authors.lastname: Muotri
mesh_terms: D002454:Cell Differentiation; D049109:Cell Proliferation; D053595:Embryonic Stem Cells / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D009422:Nervous System Diseases / Q000473:pathology*; D010641:Phenotype; D039904:Pluripotent Stem Cells / Q000473:pathology*