title: Association of neurotropic viruses in HIV-infected individuals who died of secondary complications of tuberculosis, cryptococcosis, or toxoplasmosis in South India.
abstract: The frequencies of 10 opportunistic DNA viruses were determined by multiplex real-time PCR in paired cerebrospinal fluid (CSF) and brain tissue of HIV-infected individuals. In the CSF, viruses were detectable in 45/55 cases: JC virus (JCV) in 62%, Epstein-Barr virus (EBV) in 44%, cytomegalovirus (CMV) in 25%, varicella-zoster virus (VZV) in 3.6%, herpes simplex virus 1 (HSV-1) in 1.8%, and human herpesvirus 6 (HHV-6) in 1.8% of cases. A single virus was detectable in 20 cases, 19 cases had coinfection with two viruses, and 6 cases were positive for three viruses. JCV was detectable in the CSF of 62% of cases and in 42% of brain tissues, with higher loads in progressive multifocal leukoencephalopathy (PML) (P < 0.05).
authors.affiliation: Department of Clinical Virology, Christian Medical College, Vellore, India. kannangair@cmcvellore.ac.in
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kannangai
authors.forename: Jaiprasath
authors.initials: J
authors.lastname: Sachithanandham
authors.forename: Anita
authors.initials: A
authors.lastname: Mahadevan
authors.forename: Asha Mary
authors.initials: AM
authors.lastname: Abraham
authors.forename: Gopalan
authors.initials: G
authors.lastname: Sridharan
authors.forename: Anita
authors.initials: A
authors.lastname: Desai
authors.forename: Vasanthapuram
authors.initials: V
authors.lastname: Ravi
authors.forename: Susarla Krishna
authors.initials: SK
authors.lastname: Shankar
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000401:mortality* / Q000821:virology; D001921:Brain / Q000821:virology; D002555:Cerebrospinal Fluid / Q000821:virology; D003453:Cryptococcosis / Q000150:complications / Q000401:mortality*; D004266:DNA Virus Infections / Q000453:epidemiology* / Q000821:virology; D004267:DNA Viruses / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007194:India / Q000453:epidemiology; D060885:Multiplex Polymerase Chain Reaction; D015995:Prevalence; D014123:Toxoplasmosis / Q000150:complications / Q000401:mortality*; D014376:Tuberculosis / Q000150:complications / Q000401:mortality*