title: Toll-like receptor 9 in plasmacytoid dendritic cells fails to detect parvoviruses.
abstract: Toll-like receptor 9 (TLR9) recognizes genomes of double-stranded DNA (dsDNA) viruses in the endosome to stimulate plasmacytoid dendritic cells (pDCs). However, how and if viruses with single-stranded DNA (ssDNA) genomes are detected by pDCs remain unclear. Here we have shown that despite the ability of purified genomic DNA to stimulate TLR9 and despite the ability to enter TLR9 endosomes, ssDNA viruses of the Parvoviridae family failed to elicit an interferon (IFN) response in pDCs.
authors.affiliation: Department of Immunobiology, Yale University, New Haven, CT, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Mattei
authors.forename: Susan F
authors.initials: SF
authors.lastname: Cotmore
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Peter
authors.initials: P
authors.lastname: Tattersall
authors.forename: Akiko
authors.initials: A
authors.lastname: Iwasaki
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology*; D057131:Immune Evasion; D007372:Interferons / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D017992:Parvovirus / Q000276:immunology*; D051217:Toll-Like Receptor 9 / Q000276:immunology*
chemical_list: D051217:Toll-Like Receptor 9; D007372:Interferons