title: Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction.
abstract: Hydrogen sulfide (H(2)S) has historically been considered to be a toxic gas, an environmental and occupational hazard. However, with the discovery of its presence and enzymatic production through precursors of L-cysteine and homocysteine in mammalian tissues, H(2)S has recently received much interest as a physiological signaling molecule. H(2)S is a gaseous messenger molecule that has been implicated in various physiological and pathological processes in mammals, including vascular relaxation, angiogenesis, and the function of ion channels, ischemia/reperfusion (I/R), and heart injury. H(2)S is an endogenous neuromodulator and present studies show that physiological concentrations of H(2)S enhance NMDA receptor-mediated responses and aid in the induction of hippocampal long-term potentiation. Moreover, in the field of neuronal protection, physiological concentrations of H(2)S in mitochondria have many favorable effects on cytoprotection.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Jun-tao
authors.initials: JT
authors.lastname: Kan
authors.forename: Ze-yu
authors.initials: ZY
authors.lastname: Cheng
authors.forename: Jie-fang
authors.initials: JF
authors.lastname: Chen
authors.forename: Ya-qi
authors.initials: YQ
authors.lastname: Shen
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.forename: Yi-zhun
authors.initials: YZ
authors.lastname: Zhu
mesh_terms: D000818:Animals; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology*; D028361:Mitochondrial Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008954:Models, Biological
chemical_list: D006862:Hydrogen Sulfide