title: 16(th) IHIW: anti-HLA alloantibodies of the of IgA isotype in re-transplant candidates.
abstract: In this multicentre study, sera from 803 retransplant candidates, including 775 kidney transplant recipients, were analysed with regard to the presence and specificity of anti-HLA alloantibodies of the IgA isotype using a modified microsphere-based platform. Of the kidney recipients, nearly one-third (n = 237, 31%) had IgA alloantibodies. Mostly, these antibodies were found in sera that also harboured IgG alloantibodies that could be found in a total of 572 (74%) of patients. Interestingly, IgA anti-HLA antibodies were preferentially targeting HLA class I antigens in contrast to those of the IgG isotype, which targeted mostly both HLA class I and II antigens. Donor specificity of the IgA alloantibodies could be established for over half of the 237 patients with IgA alloantibodies (n = 124, 52%). A further 58 patients had specificities against HLA-C or HLA-DP, for which no information regarding donor typing was available. In summary, these data showed in a large cohort of retransplant candidates that IgA alloantibodies occur in about one-third of patients, about half of these antibodies being donor specific.
authors.affiliation: Deptartment of Internal Medicine 3, University Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: M-L
authors.initials: ML
authors.lastname: Arnold
authors.forename: F M
authors.initials: FM
authors.lastname: Heinemann
authors.forename: P
authors.initials: P
authors.lastname: Horn
authors.forename: M
authors.initials: M
authors.lastname: Ziemann
authors.forename: N
authors.initials: N
authors.lastname: Lachmann
authors.forename: A
authors.initials: A
authors.lastname: Mühlbacher
authors.forename: A
authors.initials: A
authors.lastname: Dick
authors.forename: A
authors.initials: A
authors.lastname: Ender
authors.forename: D
authors.initials: D
authors.lastname: Thammanichanond
authors.forename: G F
authors.initials: GF
authors.lastname: Fischer
authors.forename: S
authors.initials: S
authors.lastname: Schaub
authors.forename: M
authors.initials: M
authors.lastname: Hallensleben
authors.forename: J
authors.initials: J
authors.lastname: Mytilineos
authors.forename: W E
authors.initials: WE
authors.lastname: Hitzler
authors.forename: C
authors.initials: C
authors.lastname: Seidl
authors.forename: I I N
authors.initials: II
authors.lastname: Doxiadis
authors.forename: B M
authors.initials: BM
authors.lastname: Spriewald
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000888:Antibodies, Anti-Idiotypic / Q000235:genetics / Q000276:immunology; D000918:Antibody Specificity; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D015395:Histocompatibility Antigens Class I; D006650:Histocompatibility Testing; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000235:genetics; D007074:Immunoglobulin G / Q000097:blood / Q000235:genetics; D007223:Infant; D007518:Isoantibodies / Q000235:genetics / Q000276:immunology; D016030:Kidney Transplantation; D008875:Middle Aged; D014019:Tissue Donors
chemical_list: D000888:Antibodies, Anti-Idiotypic; D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007518:Isoantibodies