title: Realistic head model design and 3D brain imaging of NIRS signals using audio stimuli on preterm neonates for intra-ventricular hemorrhage diagnosis.
abstract: In this paper we propose an auditory stimulation and near infra-red spectroscopy (NIRS) hemodynamic changes acquisition protocol for preterm neonates. This study is designed to assess the specific characteristics of neurovascular coupling to auditory stimuli in healthy and ill neonate brains. The method could lead to clinical application in intra-ventricular hemorrhage (IVH) diagnosis along with other techniques such as EEG. We propose a realistic head model creation with all useful head structures and brain tissues including the neonate fontanel for more accurate results from NIRS signals modeling. We also design a 3D imaging tool for dynamic mapping and analysis of brain activation onto the cortex surface. Results show significant differences in oxy-hemoglobin between healthy neonates and subjects with IVH.
authors.affiliation: GRAMFC, Inserm U 1105, CHU Amiens, University of Picardie Jules Verne, Amiens, France. marc.fournier@u-picardie.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Fournier
authors.forename: Mahdi
authors.initials: M
authors.lastname: Mahmoudzadeh
authors.forename: Kamran
authors.initials: K
authors.lastname: Kazemi
authors.forename: Guy
authors.initials: G
authors.lastname: Kongolo
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Dehaene-Lambertz
authors.forename: Reinhard
authors.initials: R
authors.lastname: Grebe
authors.forename: Fabrice
authors.initials: F
authors.lastname: Wallois
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D001931:Brain Mapping / Q000379:methods*; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000503:physiopathology*; D003198:Computer Simulation; D006257:Head / Q000503:physiopathology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000503:physiopathology; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared / Q000379:methods*