title: Gastric neuroendocrine tumors in our institutions according to the WHO 2010 classification.
abstract: In 2010, World Health Organization classified gastric neuroendocrine tumor (NET) as follows: NET grade (G) 1, NET G2, neuroendocrine carcinoma (NEC). We reviewed 22 gastric NETs that were encountered in our institutions. Nine, 6, and 4 were NET G1, G2, and NEC, respectively. We also encountered 3 NET G3. NET G1 was treated with observation in 2 patients, endoscopic mucosal resection (EMR) in 3, and gastrectomy in 4 patients. No recurrence was experienced during a median of 53 months of follow-up. All NET G2 was treated with gastrectomy. No patient experienced recurrence during a median of 25 months of follow-up. NET G3 was treated with gastrectomy. One patient died of liver metastasis 52 months after gastrectomy. For NEC, gastrectomy was performed in 3 cases and no patients died of tumor-related death. We conclude that the prognoses of NET G1 and G2 were good. We also experienced long-term survivors of NEC. An accumulation of more patients is needed for further investigation.
authors.affiliation: 1  Department of Surgery, Higashiosaka City General Hospital, Higashiosaka-shi, Osaka, Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Endo
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Dousei
authors.forename: Yukinobu
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hatanaka
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Taniyama
authors.forename: Amane
authors.initials: A
authors.lastname: Yamauchi
authors.forename: Wataru
authors.initials: W
authors.lastname: Kamiike
authors.forename: Junichi
authors.initials: J
authors.lastname: Nishijima
mesh_terms: D000368:Aged; D018278:Carcinoma, Neuroendocrine / Q000145:classification / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D018358:Neuroendocrine Tumors / Q000145:classification* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000145:classification* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D016896:Treatment Outcome; D057832:Watchful Waiting; D014944:World Health Organization