title: Secretion of microvesicular miRNAs in cellular and organismal aging.
abstract: Changes of factors circulating in the systemic environment during human aging have been investigated for a long time. Only recently however, miRNAs have been found to be secreted into the systemic and tissue environments where they are protected from RNAses by either carrier proteins or by being packaged into microvesicles. These miRNAs are then taken up by recipient cells, changing the cellular behavior by the classical miRNA induced silencing of target mRNAs. The origin of circulating miRNAs, however, is in most instances unclear, but senescent cells emerge as a possible source of such secreted miRNAs. Since differences in the circulating miRNAs have been found in a variety of age-associated diseases, and accumulation of senescent cells in the elderly emerges as a possible detrimental factor in aging, it is well conceivable that these miRNAs might contribute to the functional decline observed during aging of organisms. Therefore, we here give an overview on current knowledge on microvesicular secretion of miRNAs, changes of the systemic and tissue environments during aging of cells and organisms. Finally, we summarize current knowledge on miRNAs that are found to be specific for age-associated diseases.
authors.affiliation: BOKU, VIBT, University of Natural Resources and Life Sciences, Department of Biotechnology, Vienna, Austria.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Weilner
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Schraml
authors.forename: Heinz
authors.initials: H
authors.lastname: Redl
authors.forename: Regina
authors.initials: R
authors.lastname: Grillari-Voglauer
authors.forename: Johannes
authors.initials: J
authors.lastname: Grillari
mesh_terms: D000367:Age Factors; D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism; D016922:Cellular Senescence / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism; D010024:Osteoporosis / Q000235:genetics / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism*
chemical_list: D035683:MicroRNAs