title: [Expression of Th17/Treg cell in patients with psoriasis arthritis and its clinical significance].
abstract: OBJECTIVE
  To investigate the change of Th17/Treg cell in patients with psoriasis arthritis (PA) and its clinical significance.
  
  
  METHODS
  The levels of IL-17 and TGF-β1 were measured by enzyme-linked immunosorbent assay(ELISA) in PA patients (n=35) and healthy controls(n=30). The frequencies of Th17 and Treg in the peripheral blood were detected by flow cytometry.
  
  
  RESULTS
  Compared with the healthy controls, Th17/Treg in peripheral blood were significantly increased (p<0.05), Th17-related cytokine IL-17 significantly increased (p<0.05), and TGF-β1 significantly decreased (p<0.05) in the PA patients.
  
  
  CONCLUSIONS
  Th17/Treg cell and the related cytokines IL-17 and TGF-β1 may be involved in the pathogenesis of PA.
authors.affiliation: Department of Dermatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Jin-guang
authors.initials: JG
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Lai
authors.forename: Yu
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000368:Aged; D015535:Arthritis, Psoriatic / Q000097:blood / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D020381:Interleukin-17; D053773:Transforming Growth Factor beta1