title: Sibling rivalry: competition between MHC class II family members inhibits immunity.
abstract: Peptide loading of major histocompatibility complex (MHC) class II molecules in the endosomes and lysosomes of antigen-presenting cells is catalyzed by human leukocyte antigen-DM (HLA-DM) and modulated by HLA-DO. In a structural study in this issue, Guce et al. show that HLA-DO is an MHC class II mimic and functions as a competitive and essentially irreversible inhibitor of HLA-DM activity, thereby inhibiting MHC class II antigen presentation.
authors.affiliation: Child Health Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA. denzinlk@umdnj.edu
authors.forename: Lisa K
authors.initials: LK
authors.lastname: Denzin
authors.forename: Peter
authors.initials: P
authors.lastname: Cresswell
mesh_terms: D000818:Animals; D006681:HLA-D Antigens / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans
chemical_list: D006681:HLA-D Antigens; C084245:HLA-DM antigens; C046148:HLA-DO antigens