title: Lack of association between hepatitis B virus pre-S mutations and recurrence after surgical resection in hepatocellular carcinoma.
abstract: Pre-S mutation of hepatitis B virus (HBV) is known to be a risk factor for hepatocarcinogenesis. A previous study suggested that pre-S mutation(s) may associate with increased recurrence after surgical resection. In the present study, 64 patients with HBV-related hepatocellular carcinoma (HCC) were categorized into two groups according to the presence or absence of pre-S mutation(s). The clinicopathological variables of the two groups were analyzed to assess the relationship between pre-S mutations and postoperative recurrence. Nineteen patients (29.7%) had pre-S mutations;13 had a pre-S deletion, three had a pre-S2 start codon mutation, two patients had both a pre-S deletion, and a pre-S2 start codon mutation, and one patient had a pre-S2 insertion. The two groups did not differ in terms of baseline clinicopathological parameters. Cirrhosis and satellite lesion(s) were predictive factors for postoperative recurrence and poor overall survival. Recurrence-free survival (P = 0.320) and overall survival (P = 0.238) did not differ significantly when pre-S mutations were present. In conclusion, this study did not find evidence supporting the notion that pre-S mutation(s) are associated with postoperative recurrence after surgical resection.
authors.affiliation: Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Nae-Yun
authors.initials: NY
authors.lastname: Heo
authors.forename: Han Chu
authors.initials: HC
authors.lastname: Lee
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Park
authors.forename: Jang Won
authors.initials: JW
authors.lastname: Park
authors.forename: Young-Suk
authors.initials: YS
authors.lastname: Lim
authors.forename: Kang Mo
authors.initials: KM
authors.lastname: Kim
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Shim
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000821:virology*; D006514:Hepatitis B Surface Antigens / Q000235:genetics*; D006515:Hepatitis B virus / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011498:Protein Precursors / Q000235:genetics*; D012008:Recurrence; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D006514:Hepatitis B Surface Antigens; D011498:Protein Precursors