title: Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines.
abstract: The first catalytic asymmetric pseudo five-component (AB(2)C(2) type) reaction is reported. A spirocyclic chiral phosphoric acid catalyzed one-pot multicomponent reaction of aromatic aldehydes, anilines and β-ketoesters and afforded highly functionalized enantioenriched tetrahydropyridines with high levels of stereocontrol.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Xuejian
authors.initials: X
authors.lastname: Li
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Haijun
authors.initials: H
authors.lastname: Qu
authors.forename: Zhenjun
authors.initials: Z
authors.lastname: Mao
authors.forename: Xufeng
authors.initials: X
authors.lastname: Lin
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D010756:Phosphoric Acids / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000814:Aniline Compounds; D004952:Esters; D010756:Phosphoric Acids; D011725:Pyridines; D013141:Spiro Compounds; C030242:phosphoric acid; C023650:aniline