title: Fundus autofluorescence imaging in a patient with rapidly developing scotoma.
abstract: OBJECTIVE
  To evaluate the findings in a case of acute macular neuroretinopathy involving sudden development of scotomas accompanied by rapid focal increases in fundus autofluorescence.
  
  
  METHODS
  The clinical presentation of the patient was documented by color fundus photographs, fundus autofluorescence, infrared imaging, and high-resolution spectral domain optical coherence tomography. The scotomas were assessed by Humphrey visual field 10-2 and MP-1 microperimetry.
  
  
  RESULTS
  Visual field defects exhibited spatial correspondence with wedge-shaped lesions demonstrable in color fundus photographs and infrared imaging. It was notable that the lesions exhibited increased intensity on autofluorescence images obtained within 3 weeks of presentation. Optical coherence tomography revealed focal loss of photoreceptor inner segment/outer segment junctions in both eyes.
  
  
  CONCLUSIONS
  This case was distinguished by the relative rapidity with which the lesions became hyperautofluorescent in fundus autofluorescence images. Given that the bisretinoids that are the source of autofluorescence form in photoreceptor cells and are transferred to retinal pigment epithelium secondarily, the rapid increase in autofluorescence is unlikely to only reflect retinal pigment epithelium status and is more likely to be indicative of photoreceptor cell dysfunctioning and loss of structural integrity.
authors.affiliation: Department of Ophthalmology, Columbia University, New York, New York.
authors.forename: Rony
authors.initials: R
authors.lastname: Gelman
authors.forename: Royce
authors.initials: R
authors.lastname: Chen
authors.forename: Anna
authors.initials: A
authors.lastname: Blonska
authors.forename: Gaetano
authors.initials: G
authors.lastname: Barile
authors.forename: Janet R
authors.initials: JR
authors.lastname: Sparrow