title: Effect of prenatal selenium supplementation on cord blood selenium and lipid profile.
abstract: BACKGROUND
  Selenium is an essential trace element and as a component of selenoproteins it plays a key role as an antioxidant. We aimed to evaluate the effect of selenium supplementation during pregnancy on cord blood selenium content and lipid profile.
  
  
  METHODS
  This trial was performed on 166 eligible women who were randomized to receive 100 μg of selenium, as selenium-yeast (Se group) or a placebo-yeast tablet (placebo group). Umbilical cord blood samples were collected at the time of delivery and selenium concentration and lipid profile were measured.
  
  
  RESULTS
  Triglyceride levels were found to be significantly higher in the Se group than in the placebo group (p=0.01). However, no significant difference in cord blood selenium was observed between the groups nor were there any significant correlations between cord blood selenium and lipid profile parameters.
  
  
  CONCLUSIONS
  Our findings suggest that selenium supplementation in pregnant women may be associated with an increased cord-blood triglyceride level, although total cholesterol, low-density lipoprotein and high-density lipoprotein cholesterol levels did not change significantly. The clinical significance of the increased cord triglyceride concentration needs to be evaluated.
authors.affiliation: Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Boskabadi
authors.forename: Gholamali
authors.initials: G
authors.lastname: Maamouri
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Rezagholizade Omran
authors.forename: Shahin
authors.initials: S
authors.lastname: Mafinejad
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Tara
authors.forename: Margaret P
authors.initials: MP
authors.lastname: Rayman
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
authors.forename: Shima
authors.initials: S
authors.lastname: Tavallaie
authors.forename: Mohammad T
authors.initials: MT
authors.lastname: Shakeri
authors.forename: Maryam
authors.initials: M
authors.lastname: Mohammadi
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Ferns
mesh_terms: D000293:Adolescent; D000328:Adult; D019587:Dietary Supplements; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood*; D008297:Male; D011247:Pregnancy; D012643:Selenium / Q000008:administration & dosage* / Q000097:blood
chemical_list: D008055:Lipids; D012643:Selenium