title: Development and validation of the K-VSCOR for scoring Koebner's phenomenon in vitiligo/non-segmental vitiligo.
abstract: The relation of vitiligo/non-segmental vitiligo (NSV) to Koebner's phenomenon is variably appreciated. Our objective was to develop and validate a simple clinical score for Koebner's phenomenon (KP) in patients with vitiligo/NSV. The study population was composed of 351 individuals in the development sample and 285 patients in the validation sample. Seven variables were independently associated with the presence of KP: disease duration of more than 3 yr, forehead + scalp areas, eyelids, wrists, genital + belt areas, knees and tibial crests. The score computed by the weighted sum of the rounded coefficients of these seven variables ranged from 0 to 56 (mean 38.39 ± 22.93). The probability of having KP was computed as follows: exp (-2.37 + 0.1*score)/exp [1 + (-2.37 + 0.1*score)]. When applying the score to each patient in the validation and the development sample, the score maintained adequate discrimination and calibration (AUC-ROC = 0.78), arguing that KP can be adequately predicted using our score. Further studies should evaluate KP assessed by the K-VSCOR in clinical practice with the aim to determine its association with clinical profile, course and treatment response of vitiligo.
authors.affiliation: Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin, Bordeaux, France.
authors.forename: Abou
authors.initials: A
authors.lastname: Diallo
authors.forename: Katia
authors.initials: K
authors.lastname: Boniface
authors.forename: Thomas
authors.initials: T
authors.lastname: Jouary
authors.forename: Julien
authors.initials: J
authors.lastname: Seneschal
authors.forename: Fanny
authors.initials: F
authors.lastname: Morice-Picard
authors.forename: Sorilla
authors.initials: S
authors.lastname: Prey
authors.forename: Muriel
authors.initials: M
authors.lastname: Cario-André
authors.forename: Juliette
authors.initials: J
authors.lastname: Mazereeuw-Hautier
authors.forename: Alain
authors.initials: A
authors.lastname: Taieb
authors.forename: Khaled
authors.initials: K
authors.lastname: Ezzedine
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012882:Skin Tests / Q000379:methods*; D014820:Vitiligo / Q000473:pathology*; D055815:Young Adult