title: [The characteristics of lipid metabolism in children with congenital hypothyroidism against the background of substitutive therapy with L-thyroxin].
abstract: The article presents the results of study of lipid metabolism. The sample consisted of 40 children with congenital thyroid deficiency at different stage of disease compensation and receiving substitutive therapy. Such disorders of lipid metabolism as hypertriglyceridemia and decrease of concentration of high density lipoproteins are established. The results testify the increased risk of atherogenic tendency. The hyper- and dyslipidemia are more often registered in patients at the stage of sub-compensated thyroid deficiency. The correlation of dosage of thyroxin with application of L-carnitine contributes to normalization of indicators of lipid metabolism.
authors.forename: T M
authors.initials: TM
authors.lastname: Romankova
authors.forename: I L
authors.initials: IL
authors.lastname: Alimova
authors.forename: V S
authors.initials: VS
authors.lastname: Sukhorukov
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D003409:Congenital Hypothyroidism / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007223:Infant; D050356:Lipid Metabolism / Q000187:drug effects*; D008075:Lipoproteins, HDL / Q000097:blood; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol; D013974:Thyroxine