title: IFPA Senior Award Lecture: Reproductive immunology in perspective--reprogramming at the maternal-fetal interface.
abstract: Involvement of the maternal and fetal immune systems in the events of pregnancy was generally overlooked by reproductive biologists until the mid-twentieth century when many landmark explorations were reported. Now, more than half a century later, it is well understood that with the initiation of pregnancy, immune cells in mammalian uteri are reprogrammed, losing their cytotoxic potential and providing an immunosuppressive environment suitable for harboring the genetically different fetus. We propose that it is the placenta that is mainly responsible for this conversion and maintenance throughout pregnancy. Studies in our laboratory indicate that trophoblast-derived soluble HLA-G has a subtle but well defined role in programming uterine placental macrophages, a potentially destructive immune cell population. Thus, placental HLA-G plays a critical role in assuring that the developing fetus emerges unscathed at parturition.
authors.affiliation: Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Hunt
authors.forename: M G
authors.initials: MG
authors.lastname: Petroff
mesh_terms: D001363:Awards and Prizes; D005260:Female; D047109:Fetal Development / Q000276:immunology*; D059951:HLA-G Antigens / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D007113:Immunity, Innate / Q000502:physiology; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D011247:Pregnancy; D012098:Reproduction / Q000276:immunology*
chemical_list: D059951:HLA-G Antigens