title: Hierarchical structural mapping for globally optimized estimation of functional networks.
abstract: In this study, we propose a framework to map functional MRI (fMRI) activation signals using DTI-tractography. This framework, which we term functional by structural hierarchical (FSH) mapping, models the regional origin of fMRI brain activation to construct "N-step reachable structural maps". Linear combinations of these N-step reachable maps are then used to predict the observed fMRI signals. Additionally, we constructed a utilization matrix, which numerically estimates whether the inclusion of a specific structural connection better predicts fMRI, using simulated annealing. We applied this framework to a visual fMRI task in a sample of body dysmorphic disorder (BDD) subjects and comparable healthy controls. Group differences were inferred by comparing the observed utilization differences against 10,000 permutations under the null hypothesis. Results revealed that BDD subjects under-utilized several key local connections in the visual system, which may help explain previously reported fMRI findings and further elucidate the underlying pathophysiology of BDD.
authors.affiliation: Department of Psychiatry, University of Illinois, Chicago, IL, USA. alexfeuillet@gmail.com
authors.forename: Alex D
authors.initials: AD
authors.lastname: Leow
authors.forename: Liang
authors.initials: L
authors.lastname: Zhan
authors.forename: Donatello
authors.initials: D
authors.lastname: Arienzo
authors.forename: Johnson J
authors.initials: JJ
authors.lastname: GadElkarim
authors.forename: Aifeng F
authors.initials: AF
authors.lastname: Zhang
authors.forename: Olusola
authors.initials: O
authors.lastname: Ajilore
authors.forename: Anand
authors.initials: A
authors.lastname: Kumar
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
authors.forename: Jamie D
authors.initials: JD
authors.lastname: Feusner
mesh_terms: D000328:Adult; D057215:Body Dysmorphic Disorders / Q000503:physiopathology*; D063132:Connectome / Q000379:methods*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014793:Visual Cortex / Q000503:physiopathology*; D014796:Visual Perception; D055815:Young Adult