title: Effects of topiramate on dysaesthetic pain in a patient with multiple sclerosis.
abstract: Dysaesthetic pain is a common neuropathic pain in patients with multiple sclerosis. Both tricyclic antidepressants (i.e., amitriptyline and duloxetine) and antiepileptic drugs (i.e., carbamazepine, gabapentin and pregabalin) represent first-line treatment of neuropathic pain. However, topiramate, an antiepileptic drug, also demonstrated clinical efficacy in these patients. In this report we describe the case of a 42-year-old woman with an 8-year history of multiple sclerosis who developed dysaesthetic pain in the lower limbs, and was successfully treated with topiramate at a final dose of 150 mg/day. About 8 months after beginning topiramate treatment, the patient had not shown any dysaesthetic pain, and no adverse events related to topiramate had been recorded.
authors.affiliation: Department of Neuroscience, Neurology Division, Annunziata Hospital, Cosenza, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Siniscalchi
authors.forename: Luca
authors.initials: L
authors.lastname: Gallelli
authors.forename: Giovambattista
authors.initials: G
authors.lastname: De Sarro
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D035002:Lower Extremity; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000503:physiopathology; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology; D000077236:Topiramate; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose