title: Brazilian hepatitis B vaccine: a six-year follow-up in adolescents.
abstract: The protective anti-HBs titres were examined six-year post-immunisation with the Brazilian recombinant hepatitis B vaccine. After the primary vaccination, all adolescents (n = 89) responded with protective anti-HBs titres and had a geometric mean titre (GMT) of 4031.8 mIU/mL. In 2010, 94.5% maintained protective anti-HBs (> 10 mIU/mL) antibodies, with a GMT of 236.0 mIU/mL. A positive correlation was observed between the anti-HBs titres after the primary vaccination and the titres at the six-year follow-up (p < 0.01). Eleven subjects showed anti-HBs titres suggestive of a natural booster. Prostitution and tattoos/piercings were marginally associated with natural boosters in the multivariate analysis. This study showed the first data on anti-HBs persistence following the Brazilian hepatitis B vaccine in sexually active individuals and highlights its effectiveness in the medium term.
authors.affiliation: Faculdade de Enfermagem, Universidade Federal de Goiás, Goiânia, GO, Brasil.
authors.forename: Kamilla Vêncio Frauzino
authors.initials: KV
authors.lastname: Alexandre
authors.forename: Regina Maria Bringel
authors.initials: RM
authors.lastname: Martins
authors.forename: Márcia Maria de
authors.initials: MM
authors.lastname: Souza
authors.forename: Isolina Maria Xavier
authors.initials: IM
authors.lastname: Rodrigues
authors.forename: Sheila Araujo
authors.initials: SA
authors.lastname: Teles
mesh_terms: D000293:Adolescent; D001938:Brazil; D002648:Child; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology; D006801:Humans; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines