title: Modern treatment of infection and ischaemia to reduce major amputation in the diabetic foot.
abstract: Diabetic patients suffer a high rate of amputation. There are two main reasons; infection which can spread rapidly leading to overwhelming tissue destruction and severe peripheral arterial disease. Studies that have stratified patients according to the presence or absence of both peripheral arterial disease and infection have shown significantly worse outcomes in patients with both peripheral arterial disease and infection. There have been two crucial significant advances in diabetic foot care to improve the outlook of these diabetic patients. First, there has been the realisation that diabetic foot patients experience repeated crises from the rapid onset infection and need a special form of easily accessible care within a multidisciplinary diabetic foot service to provide prompt treatment of infection before it progresses to necrosis. Secondly, within such a service, prompt diagnosis of ischaemia and urgent revascularisation has been established as a further important aspect of successful management. The critical factor in saving limbs is making a rapid diagnosis of infection and ischaemia and administering the appropriate treatment early. In this way speedy healing can be achieved and this can prevent patients from needing amputations.
authors.affiliation: Diabetic Foot Clinic, King's College Hospital, London, UK. me@edmonds45.freeserve.co.uk
authors.forename: Michael
authors.initials: M
authors.lastname: Edmonds
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017719:Diabetic Foot / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D004198:Disease Susceptibility; D024881:Drug Resistance, Bacterial; D005528:Foot / Q000098:blood supply* / Q000382:microbiology / Q000601:surgery; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D006801:Humans; D007511:Ischemia / Q000150:complications / Q000188:drug therapy* / Q000601:surgery / Q000628:therapy; D009894:Opportunistic Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D010019:Osteomyelitis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D017410:Practice Guidelines as Topic; D057285:Precision Medicine; D014656:Vascular Surgical Procedures
chemical_list: D000900:Anti-Bacterial Agents