title: Biocompatibility of Ricinus comunnis polymer compared to titanium implant used in artificial hearts. Experimental study in guinea pigs.
abstract: OBJECTIVE
  The aim of the present investigation is to determine if the tissue reaction to the Riccinus communis (mamona) polymer has significant statistical difference compared to the tissue reaction provoked by the titanium implant.
  
  
  METHODS
  Thirty two Cavia porcellus were divided into four groups containing eight animals each one. We implanted the two types of materials in the retroperitoneal space of all the animals. They were sacrificed at 7, 20, 30 and 40 days after surgery and the samples were submitted to histological study.
  
  
  RESULTS
  The quantitative analysis did not show difference between the tissue reaction of the two materials (P>0.05). The analysis of the qualitative variable also did not show difference between the tissue reaction of the materials (P>0.05).
  
  
  CONCLUSIONS
  Macroscopic and microscopic results showed that the castor oil polymer implant has no significant statistical difference compared to the titanium implant tissue reaction.
authors.affiliation: CEVITA, Instituto Denton Cooley, Curitiba, PR, Brazil. kubrusly@incorcuritiba.com.br
authors.forename: Luiz Fernando
authors.initials: LF
authors.lastname: Kubrusly
authors.forename: Yorgos Luiz Santos de Salles
authors.initials: YL
authors.lastname: Graça
authors.forename: Enéas Eduardo
authors.initials: EE
authors.lastname: Sucharski
authors.forename: Ana Cristina Lira
authors.initials: AC
authors.lastname: Sobral
authors.forename: Marcia
authors.initials: M
authors.lastname: Olandoski
authors.forename: Fernando Bermudez
authors.initials: FB
authors.lastname: Kubrusly
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002368:Castor Oil / Q000627:therapeutic use*; D005355:Fibrosis / Q000473:pathology; D015726:Giant Cells; D006168:Guinea Pigs; D006354:Heart, Artificial; D006644:Histiocytes; D020007:Implants, Experimental; D008214:Lymphocytes; D008297:Male; D008422:Materials Testing; D023421:Models, Animal; D009504:Neutrophils; D011108:Polymers / Q000627:therapeutic use*; D011897:Random Allocation; D015203:Reproducibility of Results; D012278:Ricinus; D014025:Titanium / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D002368:Castor Oil; D014025:Titanium