title: Pleurodesis outcome in malignant pleural mesothelioma.
abstract: Few data exist on the pleurodesis outcome in patients with malignant pleural mesothelioma (MPM). A retrospective review of the Western Australian Mesothelioma Registry over 5 years revealed 390 evaluable patients. Only a subset of patients (42.3%) underwent pleurodesis, surgically (n=78) or by bedside instillation of sclerosants (n=87). Surgical pleurodesis showed no advantages over bedside pleurodesis in efficacy (32% vs 31% failures requiring further drainage, p=0.98), patient survival (p=0.52) or total time spent in hospital from procedure till death (p=0.36). No clinical, biochemical or radiographic parameters tested adequately predict pleurodesis outcome.
authors.affiliation: Respiratory Department, Sir Charles Gairdner Hospital, Perth, Australia.
authors.forename: Edward Thomas Hamilton
authors.initials: ET
authors.lastname: Fysh
authors.forename: Sze Khen
authors.initials: SK
authors.lastname: Tan
authors.forename: Catherine Ann
authors.initials: CA
authors.lastname: Read
authors.forename: Felicity
authors.initials: F
authors.lastname: Lee
authors.forename: Kate
authors.initials: K
authors.lastname: McKenzie
authors.forename: Nola
authors.initials: N
authors.lastname: Olsen
authors.forename: Indunil
authors.initials: I
authors.lastname: Weerasena
authors.forename: Timothy
authors.initials: T
authors.lastname: Threlfall
authors.forename: Nicholas
authors.initials: N
authors.lastname: de Klerk
authors.forename: A William
authors.initials: AW
authors.lastname: Musk
authors.forename: Y C Gary
authors.initials: YC
authors.lastname: Lee
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008654:Mesothelioma / Q000628:therapy*; D016066:Pleural Effusion, Malignant / Q000188:drug therapy; D010997:Pleural Neoplasms / Q000628:therapy*; D018700:Pleurodesis / Q000379:methods* / Q000706:statistics & numerical data; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013627:Talc / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome; D014904:Western Australia / Q000453:epidemiology
chemical_list: D013627:Talc
keywords: Mesothelioma; Pleural Disease; Thoracic Surgery