title: Regional manifold learning for deformable registration of brain MR images.
abstract: We propose a method for deformable registration based on learning the manifolds of individual brain regions. Recent publications on registration of medical images advocate the use of manifold learning in order to confine the search space to anatomically plausible deformations. Existing methods construct manifolds based on a single metric over the entire image domain thus frequently miss regional brain variations. We address this issue by first learning manifolds for specific regions and then computing region-specific deformations from these manifolds. We then determine deformations for the entire image domain by learning the global manifold in such a way that it preserves the region-specific deformations. We evaluate the accuracy of our method by applying it to the LPBA40 dataset and measuring the overlap of the deformed segmentations. The result shows significant improvement in registration accuracy on cortex regions compared to other state of the art methods.
authors.affiliation: Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Dong.Ye@uphs.upenn.edu
authors.forename: Dong Hye
authors.initials: DH
authors.lastname: Ye
authors.forename: Jihun
authors.initials: J
authors.lastname: Hamm
authors.forename: Dongjin
authors.initials: D
authors.lastname: Kwon
authors.forename: Christos
authors.initials: C
authors.lastname: Davatzikos
authors.forename: Kilian M
authors.initials: KM
authors.lastname: Pohl
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique