title: Association of left ventricular hypertrophy with high-sensitive C-reactive protein in hemodialysis patients.
abstract: BACKGROUND
  Micro inflammation and cardiovascular disease such as left ventricular hypertrophy (LVH) are common in hemodialysis (HD) patients. Hence, we have evaluated the relationship between high-sensitive C-reactive protein (hs-CRP), as an inflammation marker, and left ventricular mass index (LVMi) and left ventricular mass (LVM) in HD patients.
  
  
  METHODS
  An analytical cross-sectional study was performed in 104 HD patients. Serum hs-CRP, LVMi, LVM, and blood pressure were evaluated; demographic data and duration of HD were also recorded. Finally, results were analyzed by using Student's t test, Pearson's correlation coefficient, one-way ANOVA and multiple regression to determine the relationship between LVMi and other variables.
  
  
  RESULTS
  A total of 66 male patients (63.46 %) and 38 female patients, with a mean age of 51.75 ± 15.98 years-old, participated in this study. Hypertension was the most common underlying disease (65.4 %). The mean LVMi was 366.98 ± 120.89 g/m(2) and the mean hs-CRP was 8.55 mg/l. Eighty-nine percent of patients had LVH. The hs-CRP level was significantly associated with age and with LVM (P = 0.0001, P = 0.039, respectively). On multivariate analysis, hs-CRP and systolic blood pressure were found to be independent predictors of LVM and LVMi.
  
  
  CONCLUSIONS
  This study shows that hs-CRP and systolic BP are independent predictors of LVH in HD patients.
authors.affiliation: Urology Research Center, Guilan University of Medical Sciences, Rasht, Iran, urc1384@yahoo.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Monfared
authors.forename: Arsalan
authors.initials: A
authors.lastname: Salari
authors.forename: Ehsan
authors.initials: E
authors.lastname: Kazemnezhad
authors.forename: Mohammadkazem
authors.initials: M
authors.lastname: Lebadi
authors.forename: Masoud
authors.initials: M
authors.lastname: Khosravi
authors.forename: Neda Kalantar
authors.initials: NK
authors.lastname: Mehrjardi
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Rahimifar
authors.forename: Nazly
authors.initials: N
authors.lastname: Amini
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000209:etiology / Q000473:pathology; D007249:Inflammation / Q000097:blood* / Q000150:complications; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D006435:Renal Dialysis
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein