title: Proteoglycans in the central nervous system: role in development, neural repair, and Alzheimer's disease.
abstract: Proteoglycans (PGs) are major components of the cell surface and extracellular matrix and play critical roles in development and maintenance of the central nervous system (CNS). PGs are a family of proteins, all of which contain a core protein to which glycosaminoglycan side chains are covalently attached. PGs possess diverse physiological roles, particularly in neural development, and are also implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). The main functions of PGs in the CNS are reviewed as are the roles of PGs in brain injury and in the development or treatment of AD.
authors.affiliation: Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.
authors.forename: Hao
authors.initials: H
authors.lastname: Cui
authors.forename: Craig
authors.initials: C
authors.lastname: Freeman
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Jacobson
authors.forename: David H
authors.initials: DH
authors.lastname: Small
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D002490:Central Nervous System / Q000254:growth & development / Q000378:metabolism / Q000503:physiopathology*; D011508:Chondroitin Sulfate Proteoglycans / Q000502:physiology*; D019812:Heparan Sulfate Proteoglycans / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity; D013569:Synapses / Q000502:physiology
chemical_list: D016564:Amyloid beta-Protein Precursor; D011508:Chondroitin Sulfate Proteoglycans; D019812:Heparan Sulfate Proteoglycans