title: Does pelvic mesh treated with phosphorylcholine improve outcomes? An early experience.
abstract: OBJECTIVE
  Implantable devices treated with phosphorylcholine (PC) have been successfully used in cardiac, ophthalmic, and other applications. This surface modification has resulted in a reduction in the host inflammatory responses. This pilot study tested the safety and efficacy of PC treated polypropylene mesh grafts implanted for the treatment of pelvic organ prolapse.
  
  
  METHODS
  Surgeons from five U.S. sites collected data on subjects implanted with Perigee IntePro Lite+PC. Pre-procedure data collected included demographics and prolapse severity. At follow-up, subjects were assessed for anatomical outcomes (success≤stage I POPQ or Baden Walker), symptomatic improvement, and complications, particularly mesh exposure.
  
  
  RESULTS
  A total of 40 subjects were enrolled with 80% (32/40) of them completing at least 5-7 months of follow-up. Mean patient age was 60 years (range 36-78 years) and the mean BMI was 28 (range 20-40). There were no cases of mesh exposure/extrusion or granuloma formation. The anatomical success rate was 100% at 5-7 months (32/32).
  
  
  CONCLUSIONS
  This is the first publication on pelvic mesh treated with PC. There were no adverse events attributed to this surface modification. However, as the numbers are small, the results are not statistically significant. PC surface modification of pelvic mesh shows promise in its application for the reduction of mesh related complications.
authors.affiliation: Urologic Clinics of North Alabama, Huntsville, AL 35801, USA. amitcmd@yahoo.com
authors.forename: Amit
authors.initials: A
authors.lastname: Chakrabarty
authors.forename: Kumaresan
authors.initials: K
authors.lastname: Ganabathi
authors.forename: J Steven
authors.initials: JS
authors.lastname: Alexander
authors.forename: Philip
authors.initials: P
authors.lastname: Hoekstra
authors.forename: James
authors.initials: J
authors.lastname: Martin
authors.forename: Samuel
authors.initials: S
authors.lastname: Zylstra
mesh_terms: D000328:Adult; D000368:Aged; D040761:Biomimetic Materials / Q000009:adverse effects / Q000737:chemistry*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000503:physiopathology / Q000601:surgery*; D010767:Phosphorylcholine / Q000009:adverse effects / Q000737:chemistry*; D010865:Pilot Projects; D011126:Polypropylenes / Q000737:chemistry; D011183:Postoperative Complications / Q000517:prevention & control; D012042:Registries; D012720:Severity of Illness Index; D013499:Surface Properties; D013526:Surgical Mesh / Q000009:adverse effects*; D014481:United States
chemical_list: D011126:Polypropylenes; D010767:Phosphorylcholine