title: A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen.
abstract: To circumvent the limitations of polyethylene glycol (PEG) modified carriers, a photo-triggerable liposome was prepared which was modified by cholesterol derivatives via a cleavable vinyl ether linkage so that the PEGylated coating can be efficiently removed by a photoactivated fullerene. After the photocleavage of the PEG moiety, the intracellular uptake of the photo-triggerable liposome improved.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Chikako
authors.initials: C
authors.lastname: Komeda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ikeda
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kikuchi
authors.forename: Norihiro
authors.initials: N
authors.lastname: Ishida-Kitagawa
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tatebe
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shiozaki
authors.forename: Motofusa
authors.initials: M
authors.lastname: Akiyama
mesh_terms: D002784:Cholesterol / Q000031:analogs & derivatives* / Q000378:metabolism; D037741:Fullerenes / Q000737:chemistry* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D008027:Light; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D010782:Photolysis; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000378:metabolism; D026082:Singlet Oxygen / Q000737:chemistry* / Q000378:metabolism
chemical_list: D037741:Fullerenes; D008081:Liposomes; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D011092:Polyethylene Glycols; D002784:Cholesterol