title: Delayed development of a rhabdomyosarcoma following radiation for a spinal cord glioma.
abstract: Radiation-induced sarcomas represent a rare delayed-late secondary complication of radiation therapy. Radiation-associated sarcomas are associated with a worse overall prognosis compared to sporadic sarcomas irrespective of histological type. Herein we report a case of a 65-year old man who underwent surgery and radiation therapy for a T4 spinal cord low-grade two astrocytoma in 1965 and presented over 40 years later with spinal cord complex intramedullary tumor involving the thoracic cord with drop metastases in the lumbar spine. Histology from a partial resection of the thoracic spinal tumor revealed a high-grade rhabdomyosarcoma. In addition to the rarity of radiation-induced sarcoma arising following the treatment of a spinal cord glioma, this case study represents one of the first reports of a spinal cord rhabdomyosarcoma arising in this setting.
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Edmond
authors.initials: E
authors.lastname: Marzbani
authors.forename: Edmond
authors.initials: E
authors.lastname: Mazbani
authors.forename: Robin L
authors.initials: RL
authors.lastname: Jones
authors.forename: James
authors.initials: J
authors.lastname: Fink
authors.forename: Marc C
authors.initials: MC
authors.lastname: Chamberlain
mesh_terms: D000368:Aged; D005910:Glioma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging / Q000209:etiology*; D049268:Positron-Emission Tomography; D011878:Radiotherapy / Q000009:adverse effects*; D012208:Rhabdomyosarcoma / Q000000981:diagnostic imaging / Q000209:etiology*; D013120:Spinal Cord Neoplasms / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed