title: Clinicopathological features and prognostic factors of rectal gastrointestinal stromal tumors.
abstract: OBJECTIVE
  Rectal gastrointestinal stromal tumor (GIST) was a rare disease. This study sought to summarize clinicopathological features and prognostic factors of rectal GISTs.
  
  
  METHODS
  Clinicopathological characteristics and prognostic factors of rectal GISTs were investigated by reviewing patients undergoing curative resection at the Fudan University Shanghai Cancer Center between 1986 and 2010.
  
  
  RESULTS
  Twenty-one patients, 15 male and 6 female, were included. The mean age of onset was 51 years. The most common initial presentation was hematochezia (7 cases). Eleven patients underwent radical resection, and the other 10 received local resection. No lymph node metastases were identified. All cases were positive for CD117. Seventeen patients were classified as high National Institutes of Health (NIH) risk category. The 5-year disease-free survival (DFS) and overall survival were 33 and 46 %, respectively. Fifteen cases had recurrence postoperatively. Both univariate and multivariate analyses demonstrated the NIH risk category (p = 0.028) and hematochezia symptom (p = 0.014) were independent prognostic factors of the DFS of patients.
  
  
  CONCLUSIONS
  Hematochezia was the most common initial symptom. Over 50 % of patients received radical surgery. More than 80 % of patients were at high NIH risk of recurrence. Hematochezia symptom and high NIH risk category indicated poor prognosis of rectal GISTs.
authors.affiliation: Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, PR China.
authors.forename: C C
authors.initials: CC
authors.lastname: Xiao
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: M H
authors.initials: MH
authors.lastname: Wang
authors.forename: L Y
authors.initials: LY
authors.lastname: Huang
authors.forename: P
authors.initials: P
authors.lastname: Wu
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.forename: X L
authors.initials: XL
authors.lastname: Zhu
authors.forename: W Q
authors.initials: WQ
authors.lastname: Sheng
authors.forename: C Y
authors.initials: CY
authors.lastname: Du
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Shi
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Guan
authors.forename: S J
authors.initials: SJ
authors.lastname: Cai
authors.forename: G X
authors.initials: GX
authors.lastname: Cai
mesh_terms: D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000401:mortality* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012004:Rectal Neoplasms / Q000401:mortality* / Q000473:pathology*; D012189:Retrospective Studies