title: Preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan.
abstract: The process of preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan was studied and the optimum condition for microcapsule preparation was investigated by orthogonal array analysis. Based on the yield percentage of microcapsule, the optimum condition for microcapsule preparation was (i) core-shell ratio=1:2; (ii) chitosan concentration=6% (w/v); (iii) agitation speed=1100 rpm; and (iv) cross-linking time=90 min. Meanwhile, relative importance of the preparation parameters was in the order: core-shell ratio, agitation speed, chitosan concentration and cross-linking time. The Fourier transform infrared spectroscopy analysis revealed that Cortex Moutan has been completely encapsulated into chitosan microcapsule. The release rate of Cortex Moutan from microcapsules in pH 5.4 phosphate buffered saline (PBS) was slightly better than that in pH 5.0 PBS after the initial 48 h and the release rate became steady after that.
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
authors.forename: Patrick Chi-Leung
authors.initials: PC
authors.lastname: Hui
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Wang
authors.forename: Chi-Wai
authors.initials: CW
authors.lastname: Kan
authors.forename: Chang-E
authors.initials: CE
authors.lastname: Zhou
authors.forename: Frency Sau-Fun
authors.initials: FS
authors.lastname: Ng
authors.forename: Elaine
authors.initials: E
authors.lastname: Wat
authors.forename: Vanilla Xin
authors.initials: VX
authors.lastname: Zhang
authors.forename: Chung-Lap
authors.initials: CL
authors.lastname: Chan
authors.forename: Clara Bik-San
authors.initials: CB
authors.lastname: Lau
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Leung
mesh_terms: D002214:Capsules / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D029596:Paeonia; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; C038881:moutan cortex; D048271:Chitosan