title: CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors.
abstract: BACKGROUND
  Ameloblastomas and keratocystic odontogenic tumors (KOTs) are lesions that are characterized by locally invasive growth and cause extensive bone destruction. In addition, it is known that E-cadherin influences the adhesion of Langerhans cells (LCs) to keratinocytes.
  
  
  OBJECTIVE
  The aim of this study was to investigate, using immunohistochemistry, the distribution of CD1a-positive cells in ameloblastomas and KOTs and their relationship with E-cadherin, in comparison to calcifying cystic odontogenic tumor (CCOT).
  
  
  RESULTS
  The CD1a-positive LCs were observed in 11 ameloblastomas and KOTs. All of the cases of CCOT showed CD1a-positive LCs and a significant difference was found when this tumor was compared with ameloblastomas (P < 0.05, Mann-Whitney test). A statistically significant difference was also noted when comparing CD1a-positive LCs between CCOTs and KOTs (P < 0.05, Mann-Whitney test). Lower expression of E-cadherin in ameloblastomas (AMs) in relation to KOTs and CCOTs (P < 0.05, Fisher test) was observed. There was no correlation between E-cadherin and CD1a-positive LCs between all odontogenic tumors that were studied (P > 0.05, Spearman test).
  
  
  CONCLUSIONS
  A quantitative difference of CD1a-positive cells between AMs and KOTs in comparison to CCOTs was observed. This permits to speculate that a depletion of CD1a-positive LCs might influence the local invasiveness of ameloblastomas and KOTs. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors.
authors.affiliation: Laboratory of Oral Surgical Pathology, Department of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.
authors.forename: Leonardo Araújo
authors.initials: LA
authors.lastname: Mello
authors.forename: Andréia Leal
authors.initials: AL
authors.lastname: Figueiredo
authors.forename: Eduardo Antônio Gonçalves
authors.initials: EA
authors.lastname: Ramos
authors.forename: Clarissa Araújo Silva
authors.initials: CA
authors.lastname: Gurgel
authors.forename: Manoela Domingues
authors.initials: MD
authors.lastname: Martins
authors.forename: Claúdia Roberta Leite Vieira
authors.initials: CR
authors.lastname: de Figueiredo
authors.forename: Patrícia Ramos
authors.initials: PR
authors.lastname: Cury
authors.forename: Ricardo Luiz Cavalcanti
authors.initials: RL
authors.lastname: de Albuquerque Júnior
authors.forename: Luciana Maria Pedreira
authors.initials: LM
authors.lastname: Ramalho
authors.forename: Jean Nunes Dos
authors.initials: JN
authors.lastname: Santos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000564:Ameloblastoma / Q000473:pathology*; D018949:Antigens, CD1 / Q000032:analysis*; D015820:Cadherins / Q000032:analysis*; D002448:Cell Adhesion / Q000502:physiology; D002452:Cell Count; D048430:Cell Shape; D002648:Child; D003713:Dendritic Cells / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000473:pathology; D007801:Langerhans Cells / Q000473:pathology*; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology; D008441:Maxillary Neoplasms / Q000473:pathology; D008875:Middle Aged; D018333:Odontogenic Cyst, Calcifying / Q000473:pathology; D009808:Odontogenic Tumors / Q000473:pathology*; D055815:Young Adult
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen; D015820:Cadherins
keywords: E-cadherin; Langerhans cell; dendritic cell; odontogenic tumors