title: Overview of current sutureless and transcatheter mitral valve replacement technology.
abstract: Mitral valve (MV) regurgitation is the most prevalent form of heart valve disease. As it comes to surgical repair or replacement of the diseased valves, the procedure has been established as safe and effective; however, its invasiveness still carries considerable risk of significant morbidity and mortality. With aging comes increased MV dysfunction, and thus minimally invasive technology is rapidly evolving to meet the challenges of older patients' preoperative comorbidities and risks associated with surgery. In comparison, in high-risk patients with aortic stenosis, percutaneous transcatheter technologies offer a viable alternative to surgery; however, catheter-based procedures for MV disease are limited only to repair. MV surgeries have limitations and carry the potential for serious complications in high-risk elderly patients. A fast, reliable sutureless or catheter-based means of MV replacement is needed. Although transcatheter devices are still only in preclinical testing or developmental stages, the authors here review various sutureless MV and transcatheter-based concepts and devices for MV replacement.
authors.affiliation: Department of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Avenue/ND20, Cleveland, OH 44195, USA.
authors.forename: Jamshid H
authors.initials: JH
authors.lastname: Karimov
authors.forename: Alex L
authors.initials: AL
authors.lastname: Massiello
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
mesh_terms: D001709:Biotechnology / Q000295:instrumentation*; D062906:Cardiac Catheters; D019544:Equipment Failure Analysis; D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000601:surgery*; D011474:Prosthesis Design; D013536:Suture Techniques