title: Dietary treatment of nonalcoholic steatohepatitis.
abstract: OBJECTIVE
  Nonalcoholic steatohepatitis (NASH) is increasing in prevalence, in tandem with the U.S. obesity epidemic, in both children and adults. Identifying specific dietary components that drive NASH is important for successful management of this disease.
  
  
  RESULTS
  Weight loss of 5-10% improves NASH. In addition, fructose and trans-fats, two components of the Western 'fast-food' diet, have unique metabolic effects that suggest they may be key contributors to NASH. However, further research is needed to clarify the utility of restricting these nutrients in treating NASH.
  
  
  CONCLUSIONS
  Overall reductions in body weight, through reduced calorie intake and increased physical activity, are the current mainstays of NASH treatment. Reducing fructose and trans-fat intake, independent of weight loss, may be critical to improving or preventing progression of NASH.
authors.affiliation: Department of Pediatrics, University of California, San Francisco, California, USA.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Perito
authors.forename: Luis A
authors.initials: LA
authors.lastname: Rodriguez
authors.forename: Robert H
authors.initials: RH
authors.lastname: Lustig
mesh_terms: D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005234:Fatty Liver / Q000178:diet therapy* / Q000209:etiology; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008954:Models, Biological; D065626:Non-alcoholic Fatty Liver Disease; D044242:Trans Fatty Acids / Q000008:administration & dosage / Q000009:adverse effects; D015431:Weight Loss
chemical_list: D004040:Dietary Carbohydrates; D044242:Trans Fatty Acids; D005632:Fructose