title: Isolated leptomeningeal enhancement in tacrolimus-associated posterior reversible encephalopathy syndrome.
abstract: We report on tacrolimus-associated posterior reversible encephalopathy syndrome with the previously unreported finding of leptomeningeal enhancement occurring separate from the site of parenchymal magnetic resonance signal abnormality. Recognition of this atypical finding as a noninfectious cause of leptomeningeal enhancement may assist those caring for patients affected by posterior reversible encephalopathy syndrome.
authors.affiliation: Division of Neuroradiology, Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. fitzgeraldryant@uams.edu
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Fitzgerald
authors.forename: Joana
authors.initials: J
authors.lastname: Osorio
authors.forename: Ashok
authors.initials: A
authors.lastname: Panigrahy
authors.forename: George V
authors.initials: GV
authors.lastname: Mazariegos
authors.forename: Giulio
authors.initials: G
authors.lastname: Zuccoli
mesh_terms: D001929:Brain Edema / Q000139:chemically induced* / Q000150:complications; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007223:Infant; D008279:Magnetic Resonance Imaging; D008578:Meninges / Q000473:pathology*; D008636:Mesencephalon / Q000473:pathology; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced* / Q000150:complications; D012640:Seizures / Q000188:drug therapy; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus