title: [Diastolic dysfunction in patients with human inmunodeficiency virus. Tissue Doppler study].
abstract: The heart has rarely been studied in patients infected with HIV. Diastolic dysfunction is the most frequently observed alteration , which could be due to direct viral action on the myocardium or due to autoimmune mechanism or concomitant infections by cardiotropic virus. The Doppler tissue is a more effective tool than the trans-mitral one to evaluate the diastolic function since is not influenced by preload, afterload or heart rate.
  
  
  OBJECTIVE
  To study the prevalence of the left ventricular diastolic dysfunction (DDVI) in the HIV (+) group of patients, without symptoms or diagnosis of heart-disease and to analyze their relationship with the CD4 levels and the viral charge.
  
  
  METHODS
  We prospectively studied 50 HIV(+) patients with no symptoms of cardiac involvement who underwent an echocardiogram using Doppler tissue compared with 50 healthy persons matched sex and age as control group.
  
  
  RESULTS
  The infection of HIV was associated with DDVI and with CD4 Lymphocytes levels (p<0,05). The association between DDVI and viral load was not found.
  
  
  CONCLUSIONS
  There is an association between the HIV infection and the presence of DDVI in asymptomatic patients. The long term monitoring studies should be considered in HIV (+) patients with silent diastolic dysfunction to evaluate their possible progression to the systolic dysfunction.
authors.forename: M S
authors.initials: MS
authors.lastname: Vazques-Trabichet
authors.forename: C
authors.initials: C
authors.lastname: Costa-Calderon
authors.forename: E
authors.initials: E
authors.lastname: Pogonza
authors.forename: A
authors.initials: A
authors.lastname: Cazaux
authors.forename: J R
authors.initials: JR
authors.lastname: Cortes
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D019562:Viral Load