title: 16(th) IHIW: global distribution of extended HLA haplotypes.
abstract: This report describes the project to identify the global distribution of extended HLA haplotypes, a component of 16th International HLA and Immunogenetics Workshop (IHIW), and summarizes the initial analyses of data collected. The project aims to investigate extended HLA haplotypes, compare their distribution among different populations, assess their frequency in hematopoietic stem cell unrelated donor registries and initiate an international family studies database and DNA repository to be made publicly available. HLA haplotypes compiled in immunogenetics laboratories during the evaluation of transplant candidates and related potential donors were analysed. Haplotypes were determined using the pedigree analysis tool publicly available from the National Marrow Donor Program (NMDP) website. Nineteen laboratories from 10 countries (11 laboratories from North America, five from Asia, two from Latin America and one from Australia) contributed data on a total of 1719 families comprised of 7474 individuals. We identified 10393 HLA haplotypes, of which 1682 haplotypes included high-resolution typing at HLA-A, B, C, DRB1 and DQB1 loci. We also present haplotypes containing MICA and other HLA loci and haplotypes containing rare alleles seen in these families. The project will be extended through the 17th IHIW, and investigators interested in joining the project may communicate with the first author.
authors.affiliation: Allogen Laboratories, Cleveland Clinic, Cleveland, OH 44195, USA. askarm@ccf.org
authors.forename: M
authors.initials: M
authors.lastname: Askar
authors.forename: J
authors.initials: J
authors.lastname: Daghstani
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: N
authors.initials: N
authors.lastname: Leahy
authors.forename: P
authors.initials: P
authors.lastname: Dunn
authors.forename: F
authors.initials: F
authors.lastname: Claas
authors.forename: S
authors.initials: S
authors.lastname: Doran
authors.forename: H
authors.initials: H
authors.lastname: Saji
authors.forename: S
authors.initials: S
authors.lastname: Kanangat
authors.forename: M
authors.initials: M
authors.lastname: Karoichane
authors.forename: A
authors.initials: A
authors.lastname: Tambur
authors.forename: D
authors.initials: D
authors.lastname: Monos
authors.forename: M
authors.initials: M
authors.lastname: El-Khalifa
authors.forename: V
authors.initials: V
authors.lastname: Turner
authors.forename: M
authors.initials: M
authors.lastname: Kamoun
authors.forename: M
authors.initials: M
authors.lastname: Mustafa
authors.forename: D
authors.initials: D
authors.lastname: Ramon
authors.forename: M
authors.initials: M
authors.lastname: Gandhi
authors.forename: A
authors.initials: A
authors.lastname: Vernaza
authors.forename: C
authors.initials: C
authors.lastname: Gorodezky
authors.forename: D
authors.initials: D
authors.lastname: Wagenknecht
authors.forename: M
authors.initials: M
authors.lastname: Gautreaux
authors.forename: A
authors.initials: A
authors.lastname: Hajeer
authors.forename: Z
authors.initials: Z
authors.lastname: Kashi
authors.forename: M
authors.initials: M
authors.lastname: Fernandez-Vina
mesh_terms: D001315:Australia; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D005838:Genotype; D006680:HLA Antigens / Q000145:classification / Q000235:genetics*; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D009656:North America; D044382:Population Groups / Q000235:genetics*
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A