title: Chemical composition and anti-proliferative properties of Bursera graveolens essential oil.
abstract: Bursera graveolens is a wild tree of commercial importance native to the Neotropics, which has been widely used in folk medicine. In the present study, the chemical composition and anti-proliferative properties of the essential oil from B. graveolens were assayed. The chemical composition of the essential oil, determined by GC-MS, was complex and dominated by limonene (26.5%). Bursera oil inhibited the growth of MCF-7 breast tumor cells as well as amastigotes of L. amazonensis, with IC50 values of 48.9 +/- 4.3 and 36.7 +/- 4.7 microg/mL, respectively. In addition, the cytotoxicity of the oil was 103.9 +/- 7.2 microg/mL against peritoneal macrophages from BALB/c mice. These results demonstrate that the essential oil from B. graveolens is a promissory antiproliferative product.
authors.affiliation: Institute of Medicine Tropical "Pedro Kouri", Havana City, Cuba. monzote@ipk.sld.cu
authors.forename: Lianet
authors.initials: L
authors.lastname: Monzote
authors.forename: Gabrielle M
authors.initials: GM
authors.lastname: Hill
authors.forename: Armando
authors.initials: A
authors.lastname: Cuellar
authors.forename: Ramón
authors.initials: R
authors.lastname: Scull
authors.forename: William N
authors.initials: WN
authors.lastname: Setzer
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D000981:Antiprotozoal Agents / Q000032:analysis*; D031233:Bursera / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D061986:MCF-7 Cells; D017737:Macrophages, Peritoneal / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000981:Antiprotozoal Agents; D009822:Oils, Volatile