title: Roadblocks to translational challenges on viral pathogenesis.
abstract: Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive meeting in 2012, as part of the "Herrenhausen Symposia" series. Current challenges for various fields of viral research were recognized and discussed with a goal in mind--to identify solutions and propose an agenda to address the translational barriers. Here, some of the researchers who participated at the meeting provide a concise outlook at the most pressing unmet research and clinical needs, identifying these key obstacles is a necessary step towards the prevention and cure of human viral diseases.
authors.affiliation: Department of Medicine, University of California-San Francisco, San Francisco, California, USA. sdeeks@php.ucsf.edu
authors.forename: Steven
authors.initials: S
authors.lastname: Deeks
authors.forename: Christian
authors.initials: C
authors.lastname: Drosten
authors.forename: Louis
authors.initials: L
authors.lastname: Picker
authors.forename: Kanta
authors.initials: K
authors.lastname: Subbarao
authors.forename: Joann
authors.initials: J
authors.lastname: Suzich
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D000818:Animals; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007251:Influenza, Human / Q000821:virology; D009975:Orthomyxoviridae / Q000235:genetics / Q000472:pathogenicity; D011323:Primates / Q000821:virology; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy / Q000517:prevention & control; D057170:Translational Research, Biomedical; D014777:Virus Diseases / Q000188:drug therapy / Q000517:prevention & control / Q000821:virology; D014780:Viruses / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity
chemical_list: D016915:AIDS Vaccines; D000998:Antiviral Agents