title: Retrospective analysis of the relationship between decline in FEV(1) and abdominal circumference in male smokers: the Takahata study.
abstract: BACKGROUND
  Metabolic syndrome (Mets) is reportedly associated with chronic obstructive pulmonary disease (COPD). However, the relationship between abdominal circumference (AC) and decline in FEV(1) has not been elucidated. We aimed to investigate this relationship among male current smokers.
  
  
  METHODS
  Spirometry was performed on subjects (n = 3,257) ≥ 40 years of age, who participated in a community-based annual health check in Takahata, Japan, from 2004 through 2006 (visit 1). Spirometry was re-evaluated, and AC was assessed in 147 of the male current smokers in 2009 (visit 2). The diagnosis of Mets was based on the criteria used in the Hisayama Study.
  
  
  RESULTS
  No significant relationships were observed between AC and spirometric parameters such as % predicted forced vital capacity (FVC), % predicted forced expiratory volume in 1 s (FEV(1)) and FEV(1)/FVC. However, decline in FEV(1) was significantly correlated with AC. Multivariate logistic regression analysis showed that AC was a significant discriminating factor for decline in FEV(1), independently of age, Brinkman index and change in body mass index from visit 1 to visit 2. At visit 2, there was a greater prevalence of decline in FEV(1) among subjects with Mets (n=17) than among those without Mets. Although there were no differences in % predicted FVC, % predicted FEV(1) or FEV(1)/FVC between subjects with or without Mets, the rate of decline in FEV(1) was significantly greater in subjects with Mets than in those without.
  
  
  CONCLUSIONS
  This retrospective analysis suggested that measuring AC may be useful for discriminating male smokers who show a decline in FEV(1).
authors.affiliation: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Sato
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shibata
authors.forename: Shuichi
authors.initials: S
authors.lastname: Abe
authors.forename: Sumito
authors.initials: S
authors.lastname: Inoue
authors.forename: Akira
authors.initials: A
authors.lastname: Igarashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Aida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kishi
authors.forename: Keiko
authors.initials: K
authors.lastname: Nunomiya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
authors.forename: Kento
authors.initials: K
authors.lastname: Sato
authors.forename: Tetsu
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Konta
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.forename: Takamasa
authors.initials: T
authors.lastname: Kayama
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005541:Forced Expiratory Volume / Q000502:physiology*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects / Q000503:physiopathology; D013223:Statistics as Topic; D014797:Vital Capacity / Q000502:physiology; D055105:Waist Circumference / Q000502:physiology*
keywords: abdominal circumference; decline in FEV1; health check.; smoker