title: ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice.
abstract: The APOE-ɛ4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-ɛ4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-ɛ4 on cognitive functions.
authors.affiliation: Laboratoire d'Imagerie et de Neurosciences Cognitives, UMR 7237 CNRS, Université de Strasbourg, IFR 37, GDR CNRS 2905, 12 rue Goethe, F-67000 Strasbourg, France.
authors.forename: Pierre-Henri
authors.initials: PH
authors.lastname: Moreau
authors.forename: Jean-Bastien
authors.initials: JB
authors.lastname: Bott
authors.forename: Celina
authors.initials: C
authors.lastname: Zerbinatti
authors.forename: John Joseph
authors.initials: JJ
authors.lastname: Renger
authors.forename: Christian
authors.initials: C
authors.lastname: Kelche
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Cassel
authors.forename: Chantal
authors.initials: C
authors.lastname: Mathis
mesh_terms: D000818:Animals; D053318:Apolipoprotein E3 / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D001522:Behavior, Animal / Q000502:physiology*; D058685:Genetic Pleiotropy / Q000235:genetics; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D013028:Space Perception / Q000502:physiology*
chemical_list: D053318:Apolipoprotein E3; D053327:Apolipoprotein E4