title: [Antibody-drug conjugates and their application in the treatment of hematological malignancies].
abstract: Monoclonal antibody-targeted therapy has been a hot spot in current clinical cancer treatment. As current antibody drugs have large molecule sizes leading to poor tissue penetration, and high dosage in clinical application leading to high cost, to overcome the problems, the development of new antibody drugs with miniaturization and high potency has become a new trend. In recent years, the conjugates of monoclonal antibodies and cytotoxins, called antibody-drug conjugates (ADCs), have entered the arsenal of anti-cancer drugs, becoming a new format of antibody drugs and attracting extensive attentions. The ADC molecule usually consists of antibody, linker and effector molecule. According to different effector molecules, ADCs can be divided into three categories as chemo-conjugates, immunotoxins and radio-conjugates. When ADC molecules are internalized into cancer cells, cytotoxins will be released by chemical, enzyme degradation or by action of lysosomal proteases, then kill targeted cells by inhibiting protein synthesis, depolymerizing microtubules or breaking double-strand DNA. Recently, two ADC drugs have been approved by the US FDA and more ADC drug candidates are in clinical phase II or III trials which show significantly clinical effects and attracting much attention and competition of pharmaceutical enterprises. In this review, antibody conjugates in the past and present will be summarized and the future development trends and challenges of this type of antibody drugs will be discussed.
authors.affiliation: Department of Biochemistry, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Qian
authors.initials: Q
authors.lastname: Ding
authors.forename: Qin
authors.initials: Q
authors.lastname: Tang
authors.forename: Zhen-zhen
authors.initials: ZZ
authors.lastname: Zhang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Dai
authors.forename: Jin-biao
authors.initials: JB
authors.lastname: Zhan
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D019337:Hematologic Neoplasms / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods; D000922:Immunotoxins / Q000737:chemistry / Q000627:therapeutic use*; D016499:Radioimmunotherapy / Q000379:methods
chemical_list: D015703:Antigens, CD; D018796:Immunoconjugates; D000922:Immunotoxins