title: Radial glia - from boring cables to stem cell stars.
abstract: The discovery in the year 2000 that radial glial cells act as neural stem and progenitor cells in development has led to a change in the concept of neural stem cells in the adult brain. Not only are adult stem cells in the neurogenic niches glial in nature, but also glial cells outside these niches display greater potential when reacting to brain injury. Thus, a concept that emerged from developmental studies may hold the clue for neural repair.
authors.affiliation: IRCCS-AOU San Martino-IST, Largo Rosanna Benzi 10, 16132, Genoa- Italy. paolo.malatesta@unige.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Malatesta
authors.forename: Magdalena
authors.initials: M
authors.lastname: Götz
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D019070:Cell Lineage; D049109:Cell Proliferation; D002999:Clone Cells / Q000166:cytology / Q000502:physiology; D005136:Eye Proteins / Q000235:genetics; D005434:Flow Cytometry; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology* / Q000502:physiology; D055495:Neurogenesis; D009457:Neuroglia / Q000166:cytology* / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics
chemical_list: D015415:Biomarkers; D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins