title: Intrinsic microvasculature of the sciatic nerve in the rat.
abstract: Microvasculature associated with the sciatic nerve was examined using high-resolution micro-CT scanning in one group of rats and surgical exploration in another. The results indicate that blood supply to the sciatic nerve is an "open-ended" system in which the vessels run longitudinally within the epineurium and connect with external vasculature primarily at junction points. Although the range of vasculature found extended down to 4-5 μ, only a few isolated vessels of this size were found, with no capillary "mesh" as such, possibly because of the close proximity of the intrinsic vessel to nerve fibers within the epineurium. While the study did not include direct measurements of flow or nerve function, the "open-ended" pattern of vasculature found has important implications regarding the relationship between the two. Specifically, the nerve is less vulnerable to a severe or complete disruption in blood supply than it would be under a close-ended system such as that of the heart or brain, where a severe disruption can occur with the obstruction of only a single vessel. Indeed, the pattern of vasculature found, subject to further study of vasculature at the capillary level, suggests that flow within the intrinsic vessels may be in either direction, depending on circumstances, somewhat like flow within the circle of Willis in the cerebral circulation.
authors.affiliation: Neurovascular Research Laboratory, School of Kinesiology, Western University, London, Ontario, Canada. zamir@uwo.ca
authors.forename: Mair
authors.initials: M
authors.lastname: Zamir
authors.forename: Jasna
authors.initials: J
authors.lastname: Twynstra
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Vercnocke
authors.forename: Ian
authors.initials: I
authors.lastname: Welch
authors.forename: Steve M
authors.initials: SM
authors.lastname: Jorgensen
authors.forename: Erik L
authors.initials: EL
authors.lastname: Ritman
authors.forename: David W
authors.initials: DW
authors.lastname: Holdsworth
authors.forename: J Kevin
authors.initials: JK
authors.lastname: Shoemaker
mesh_terms: D000818:Animals; D002941:Circle of Willis / Q000033:anatomy & histology / Q000601:surgery; D007091:Image Processing, Computer-Assisted; D055806:Microvessels / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000601:surgery; D010525:Peripheral Nerves / Q000033:anatomy & histology / Q000098:blood supply / Q000601:surgery; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000502:physiology; D012584:Sciatic Nerve / Q000033:anatomy & histology / Q000098:blood supply* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed