title: Predicting the external formation of callus tissues in oblique bone fractures: idealised and clinical case studies.
abstract: It is proposed that the external asymmetric formation of callus tissues that forms naturally about an oblique bone fracture can be predicted computationally. We present an analysis of callus formation for two cases of bone fracture healing: idealised and subject-specific oblique bone fractures. Plane strain finite element (FE) models of the oblique fractures were generated to calculate the compressive strain field experienced by the immature callus tissues due to interfragmentary motion. The external formations of the calluses were phenomenologically simulated using an optimisation style algorithm that iteratively removes tissue that experiences low strains from a large domain. The resultant simulated spatial formation of the healing tissues for the two bone fracture cases showed that the calluses tended to form at an angle equivalent to the angle of the oblique fracture line. The computational results qualitatively correlated with the callus formations found in vivo. Consequently, the proposed methods show potential as a means of predicting callus formation in pre-clinical testing.
authors.affiliation: School of Engineering, Bahrain Polytechnic, Isa Town, Kingdom of Bahrain, damien.comiskey2@mail.dcu.ie.
authors.forename: D
authors.initials: D
authors.lastname: Comiskey
authors.forename: B J
authors.initials: BJ
authors.lastname: MacDonald
authors.forename: W T
authors.initials: WT
authors.lastname: McCartney
authors.forename: K
authors.initials: K
authors.lastname: Synnott
authors.forename: J
authors.initials: J
authors.lastname: O'Byrne
mesh_terms: D002146:Bony Callus / Q000473:pathology* / Q000503:physiopathology; D019245:Compressive Strength; D003198:Computer Simulation; D020342:Finite Element Analysis; D017102:Fracture Healing; D050723:Fractures, Bone / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D055815:Young Adult