title: Aging signaling pathways and circadian clock-dependent metabolic derangements.
abstract: The circadian clock machinery orchestrates organism metabolism to ensure that development, survival, and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissue homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient-sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms.
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain.
authors.forename: Maria Florencia
authors.initials: MF
authors.lastname: Tevy
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Giebultowicz
authors.forename: Zachary
authors.initials: Z
authors.lastname: Pincus
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Mazzoccoli
authors.forename: Manlio
authors.initials: M
authors.lastname: Vinciguerra
mesh_terms: D000375:Aging; D000818:Animals; D031204:Caloric Restriction; D057906:Circadian Clocks; D004032:Diet / Q000009:adverse effects; D004195:Disease Models, Animal; D004734:Energy Metabolism; D005247:Feeding Behavior; D006801:Humans; D008136:Longevity; D008659:Metabolic Diseases / Q000378:metabolism* / Q000517:prevention & control; D015398:Signal Transduction; D013045:Species Specificity