title: Effect of processing variables on characterization of ofloxacin loaded lipospheres prepared by melt dispersion technique.
abstract: A melt dispersion technique was employed to prepare ofloxacin lipospheres, by using cetyl alcohol (polar lipid). Effects of various process parameters such as selection of surfactants (gelatin, Tween 40 and poly vinyl alcohol) and selection of stirring speed were studied. Lipospheres were evaluated for morphology, drug entrapment and in vitro drug release profiles. The optimized liposphere batch was selected and formulated as tablets and evaluated the in vitro drug release profile. These studies showed that ofloxacin loaded lipospheres were able to control the drug release for a period of 16h.
authors.affiliation: Research scholar, Karpagam University, Echanari Post, Coimbatore, India.. satheeshbabumpharm@gmail.com.
authors.forename: Satheesh Babu
authors.initials: SB
authors.lastname: Natarajan
authors.forename: Prabakaran
authors.initials: P
authors.lastname: Lakshmanan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004339:Drug Compounding; D005233:Fatty Alcohols / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry; D008081:Liposomes; D015242:Ofloxacin / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D013607:Tablets
chemical_list: D000900:Anti-Bacterial Agents; D005233:Fatty Alcohols; D008081:Liposomes; D011136:Polysorbates; D013501:Surface-Active Agents; D013607:Tablets; D005780:Gelatin; D011142:Polyvinyl Alcohol; C005031:cetyl alcohol; D015242:Ofloxacin; C068430:polysorbate 40