title: Localized pemphigus with vegetative features.
abstract: We present a 58-year-old Jamaican man with an eight-month history of an isolated, vegetative, eroded, and crusted plaque on the posterior aspect of the scalp. One month prior to referral to the Charles C. Harris Skin and Cancer Pavilion he developed a few, scattered erosions on the extremities. A biopsy specimen showed suprabasal acantholysis along with deposition of C3 and IgG on a direct immunofluorescence test. Localized pemphigus is a rare variant of pemphigus vulgaris. Localized pemphigus presents with a localized plaque that remains localized for an extended period of time without generalized bullae formation. Our patient represents an unusual case of localized pemphigus of the scalp with vegetative features.
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Lehrhoff
authors.forename: Kristen
authors.initials: K
authors.lastname: Miller
authors.forename: Max
authors.initials: M
authors.lastname: Fischer
authors.forename: Hideko
authors.initials: H
authors.lastname: Kamino
authors.forename: Shane
authors.initials: S
authors.lastname: Meehan
mesh_terms: D000505:Alopecia / Q000209:etiology; D001323:Autoantibodies / Q000097:blood; D051183:Desmoglein 1 / Q000276:immunology; D051184:Desmoglein 3 / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008206:Lymphatic Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000473:pathology*; D012536:Scalp Dermatoses / Q000473:pathology*
chemical_list: D001323:Autoantibodies; C495297:DSG1 protein, human; C071894:DSG3 protein, human; D051183:Desmoglein 1; D051184:Desmoglein 3; D007074:Immunoglobulin G