title: [Association between IL-10 gene polymorphisms and the outcomes of hepatitis C virus infection among high risk populations in Jiangsu province].
abstract: OBJECTIVE
  To explore the relationship between interleukin (IL)-10 gene polymorphisms and the susceptibility or the outcomes of HCV infection among high-risk populations in Jiangsu province.
  
  
  METHODS
  IL-10 gene SNPs were detected in 1555 subjects including 264 self-limited HCV infections. 371 persistent HCV infections and 920 healthy controls were selected through Taqman-MGB.
  
  
  RESULTS
  After adjusted for cofounders as sex, age and high-risk population, data from logistic regression analysis showed that the distribution of IL-10 genotypes among the controls, spontaneous clearances and those with persistent infections did not show much differences.
  
  
  RESULTS
  from further stratified analysis showed that, at the position of -819T/C, when compared with TT genotype, TC genotype had a significantly increasing chance of self-limited HCV infection among middle-aged, females and paid blood doners (adjusted OR values and 95%CI were: 2.160, 1.163 - 4.011; 1.693, 1.066 - 2.688 and 4.084, 1.743 - 9.570). It also had a lower risk of progressing to persistent HCV infection among those paid blood doners (the adjusted OR values and 95%CI were: 0.312, 0.130 - 0.747). CC genotype had a higher chance of self-limited HCV infection among people underwent blood dialysis (the adjusted OR values and 95%CI were: 2.120, 1.071 - 4.197).
  
  
  RESULTS
  also showed a decreased risk of progressing to persistent infection among paid blood doners (the adjusted OR values and 95%CI were: 0.156, 0.043 - 0.566). At the position of -592A/C, when compared to AA genotype, the AC genotype had a significantly increasing chance of self-limited HCV infection among middle-aged, females and paid blood doners (the adjusted OR values and 95%CI were: 2.176, 1.173 - 4.037; 1.659, 1.055 - 2.607; 3.704, 1.625 - 8.443) but had an increased risk of persistent HCV infection among females (the adjusted OR values and 95%CI were: 1.525, 1.017 - 2.286). AC genotype showed an increased opportunity to progress to HCV persistent infection among drug users (the adjusted OR values and 95%CI were: 1.845, 1.122 - 3.034) but had a reduced risk of progressing to HCV persistent infection among paid blood doners (the adjusted OR values and 95%CI were: 0.361, 0.155 - 0.841). CC genotype had an increased opportunity to self-limited HCV infection as well as having a decreased risk of progressing to persistent infection among paid blood doners (the adjusted OR values and 95%CI were: 3.125, 1.016 - 9.605; 0.218, 0.063 - 0.748). At the position of -1082A/G, AG/GG genotypes had an increased chance of self-limited infection among blood doners (the adjusted OR values and 95%CI were: 3.780, 1.620 - 8.820).
  
  
  CONCLUSIONS
  IL-10-819T/C, -592A/C, -1082A/G SNPs might be related with the susceptibility and the outcomes of HCV infection among populations at high risk.
authors.affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Ling-yan
authors.initials: LY
authors.lastname: Tang
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Rong-bin
authors.initials: RB
authors.lastname: Yu
authors.forename: Jing
authors.initials: J
authors.lastname: Su
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.forename: Zhi-hang
authors.initials: ZH
authors.lastname: Peng
authors.forename: Xiao-zhao
authors.initials: XZ
authors.lastname: Deng
authors.forename: Wei-liang
authors.initials: WL
authors.lastname: Ding
authors.forename: Zhi-jun
authors.initials: ZJ
authors.lastname: Ge
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D016174:Hepacivirus; D006526:Hepatitis C / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10