title: 4-(8-Quinolyl)amino-7-nitro-2,1,3-benzoxadiazole as a new colorimetric probe for rapid and visual detection of Hg2+.
abstract: 4-Amino-7-nitro-2,1,3-benzoxadiazole (ANBD) usually serves as a scaffold for developing fluorescent probes. In this paper, however, ANBD has been used as a chromogenic unit to design a new colorimetric probe, 4-(8-quinolyl)amino-7-nitro-2,1,3-benzoxadiazole (1), for rapid and visual detection of Hg(2+). The reaction of 1 with Hg(2+) in NaH(2)PO(4)-Na(2)HPO(4) buffer (pH 7.0) containing 70% (v/v) acetonitrile forms a 1:1 complex, accompanying a red shift of the absorption maximum from 482 nm to 557 nm and a distinct color change from orange to violet. Moreover the color reaction exhibits a high selectivity and sensitivity to Hg(2+) only, instead of other common metal ions. This behavior may be ascribed to the formation of a specific 1-Hg(2+) complex, which is supported by (1)H NMR titration experiments. The present study is not only a supplement to the detection method of Hg(2+), but also a merit to the chemistry of 4-amino-7-nitro-2,1,3-benzoxadiazole.
authors.affiliation: Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang 050011, China. wkecdc@163.com
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Lixue
authors.initials: L
authors.lastname: Yang
authors.forename: Chuan
authors.initials: C
authors.lastname: Zhao
authors.forename: Huimin
authors.initials: H
authors.lastname: Ma
mesh_terms: D002413:Cations, Divalent / Q000032:analysis; D003124:Colorimetry / Q000191:economics / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry*; D008628:Mercury / Q000032:analysis*; D010069:Oxadiazoles / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D002413:Cations, Divalent; D005456:Fluorescent Dyes; D010069:Oxadiazoles; D008628:Mercury