title: Towards computer-assisted deep brain stimulation targeting with multiple active contacts.
abstract: We present a novel method for preoperative computer-assisted deep brain stimulation (DBS) electrode targeting that takes into account the multiplicity of available contacts and their polarity. Our framework automatically evaluates the efficacy of many possible electrode orientations to optimize the interplay between the extracellular electric field, created from distinct arrangements of active contacts, and anatomical structures responsible for therapeutic and potential side effects. Experimental results on subthalamic DBS cases suggest bipolar configurations provide more flexibility and control on the spread of electric field and, consequently, are most robust to targeting imprecision. Visualization of predicted efficacy maps provides surgeons with complementary feedback that can bridge the gap between insertion safety and optimal therapeutic efficacy. Overall, this work adds a new dimension to preoperative DBS planning and suggests new insights regarding multi-target stimulation.
authors.affiliation: McConnell Brain Imaging Centre, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, H3A 2B4, Canada. silvain.beriault@mail.mcgill.ca
authors.forename: Silvain
authors.initials: S
authors.lastname: Bériault
authors.forename: Yiming
authors.initials: Y
authors.lastname: Xiao
authors.forename: Lara
authors.initials: L
authors.lastname: Bailey
authors.forename: D Louis
authors.initials: DL
authors.lastname: Collins
authors.forename: Abbas F
authors.initials: AF
authors.lastname: Sadikot
authors.forename: G Bruce
authors.initials: GB
authors.lastname: Pike
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology; D001931:Brain Mapping / Q000379:methods; D003198:Computer Simulation; D046690:Deep Brain Stimulation / Q000295:instrumentation* / Q000379:methods*; D004566:Electrodes; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D015233:Models, Statistical; D009493:Neurosurgery / Q000379:methods*; D010300:Parkinson Disease / Q000628:therapy*; D012815:Signal Processing, Computer-Assisted; D012984:Software; D025321:Surgery, Computer-Assisted / Q000379:methods*