title: [The factors predicting early efficacy of intravenous thrombolysis with alteplase in acute ischemic stroke].
abstract: OBJECTIVE
  To analyze the factors affecting on early efficacy of intravenous thrombolysis with alteplase.
  
  
  METHODS
  The clinical data of 100 acute cerebral infarction patients treated by intravenous thrombolysis with alteplase were retrospectively analyzed. The patients were divided into early effective group and ineffective group, which assessed by National Institute of Health Stroke Scale (NIHSS) with criteria of whether there were > 3 or not at 24 hours after therapy. Univariate analysis and multivariate logistic regression analysis were used to determine the differences of clinical data between the two groups.
  
  
  RESULTS
  Univariate analysis revealed that the early improvement was significantly associated with favorable outcome at 3 month (P = 0.000). Multivariate logistic analysis revealed that the systolic pressure at baseline was moderately positively associated with early improvement (OR 1.031, 95%CI 1.008 - 1.056, P = 0.009).
  
  
  CONCLUSIONS
  Moderately lower baseline systolic pressure is associated with early improvement after thrombolytic therapy which is associated with favorable outcome at 3 month.
authors.affiliation: Department of Neurology, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai 200127, China.
authors.forename: Ye-ping
authors.initials: YP
authors.lastname: Song
authors.forename: Yan-sheng
authors.initials: YS
authors.lastname: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator