title: Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats.
abstract: The pathology of a gastric ulcer is complex and multifactorial. Gastric ulcers affect many people around the world and its development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. In this study, we evaluated the ethanolic extract of Rosmarinus officinalis L. (eeRo); this plant, more commonly known as rosemary, has attracted the interest of the scientific community due to its numerous pharmacological properties and their potential therapeutic applications. Here, we tested the preventive effects of eeRo against gastric ulcer induced by 70% ethanol in male Wistar rats. In addition, we aimed to clarify the mechanism involved in the preventive action of the eeRo in gastric ulcers. Based on the analysis of markers of oxidative damage and enzymatic antioxidant defense systems, the measurement of nitrite and nitrate levels and the assessment of the inflammatory response, the eeRo exhibited significant antioxidant, vasodilator and antiinflammatory properties.
authors.affiliation: Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus UFSM, 97105-900 Santa Maria, RS, Brazil.
authors.forename: Guilherme Pires
authors.initials: GP
authors.lastname: Amaral
authors.forename: Nelson Rodrigues
authors.initials: NR
authors.lastname: de Carvalho
authors.forename: Rômulo Pillon
authors.initials: RP
authors.lastname: Barcelos
authors.forename: Fernando
authors.initials: F
authors.lastname: Dobrachinski
authors.forename: Rafael de Lima
authors.initials: Rde L
authors.lastname: Portella
authors.forename: Michele Hinerasky
authors.initials: MH
authors.lastname: da Silva
authors.forename: Thiago Henrique
authors.initials: TH
authors.lastname: Lugokenski
authors.forename: Glaecir Roseni Mundstock
authors.initials: GR
authors.lastname: Dias
authors.forename: Sônia Cristina Almeida
authors.initials: SC
authors.lastname: da Luz
authors.forename: Aline Augusti
authors.initials: AA
authors.lastname: Boligon
authors.forename: Margareth Linde
authors.initials: ML
authors.lastname: Athayde
authors.forename: Marcos Antonio
authors.initials: MA
authors.lastname: Villetti
authors.forename: Félix Alexandre
authors.initials: FA
authors.lastname: Antunes Soares
authors.forename: Roselei
authors.initials: R
authors.lastname: Fachinetto
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D000431:Ethanol / Q000737:chemistry* / Q000633:toxicity*; D008297:Male; D018384:Oxidative Stress; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027542:Rosmarinus / Q000737:chemistry*; D013276:Stomach Ulcer / Q000517:prevention & control*
chemical_list: D010936:Plant Extracts; D000431:Ethanol