title: Cancer cell detection based on the interaction between an anticancer drug and cell membrane components.
abstract: Simple and general cancer cell detection methods are required in point-of-care diagnostics. Herein, the interaction between an anticancer drug, daunomycin, and cancer cell membrane components has been studied using an aptamer probe immobilized on a conducting polymer-gold nanoparticle composite film through electrochemical and fluorescence methods and applied to the quantitative detection of cancer cells. The developed method differentiates between cancerous and noncancerous cells effectively.
authors.affiliation: Department of Chemistry and Institute of Bio-Physico Sensor Technology, Pusan National University, Busan 609-735, South Korea.
authors.forename: Pranjal
authors.initials: P
authors.lastname: Chandra
authors.forename: Hui-Bog
authors.initials: HB
authors.lastname: Noh
authors.forename: Yoon-Bo
authors.initials: YB
authors.lastname: Shim
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism*; D052157:Aptamers, Nucleotide / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D003630:Daunorubicin / Q000378:metabolism*; D004563:Electrochemistry; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D015336:Molecular Probe Techniques
chemical_list: D000970:Antineoplastic Agents; D052157:Aptamers, Nucleotide; D006046:Gold; D003630:Daunorubicin