title: Triterpenoid saponins from rhizomes of Paris polyphylla var. yunnanensis.
abstract: Phytochemical investigation of the rhizomes of Paris polyphylla var. yunnanensis resulted in the isolation of six new oleanane-type triterpenoid saponins, paritrisides A-F (1-6), along with nine known triterpenoid saponins (7-15). The structures of the new compounds were elucidated on the basis of spectroscopic analysis and acid hydrolysis. All the triterpenoid saponins are obtained for the first time from the genus Paris. The isolated compounds were assayed for their cytotoxic activities against human nasopharyngeal carcinoma epithelial (CNE) cells, and compounds 7, 8, and 10 exhibited inhibitory effects on CNE cell growth with IC50 values of 16.53, 16.77, and 12.69 μm, respectively.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Xia
authors.initials: X
authors.lastname: Wu
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.forename: Xin-Xin
authors.initials: XX
authors.lastname: Yang
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
mesh_terms: D019668:Liliaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D012503:Saponins; D014315:Triterpenes