title: Optimizing prostate biopsy.
abstract: Prostate biopsy (PBx) techniques have changed significantly since the original Hodge's scheme. Although the use of transrectal ultrasound (TRUS) guided (PBx) is considered the gold standard for the diagnosis of prostate cancer (Pca), the strategies for initial and repeat biopsies remain controversial. Even with the widespread application of extended prostate biopsy (ePBx) protocols, the false negative rate remains substantial and early PCa detection remains limited. Optimization of the PBx procedures reduce the likelihood of facing a "repeat biopsy dilemma". The aim of this review is to provide an evidence-based update on current methods of PBx and discuss the strategies to optimise biopsy procedures.
authors.affiliation: New York University School of Medicine, New York, NY 10016, USA. bob.djavan@nyumc.org
authors.forename: Y
authors.initials: Y
authors.lastname: Bostanci
authors.forename: A
authors.initials: A
authors.lastname: Kazzazi
authors.forename: B
authors.initials: B
authors.lastname: Djavan
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D000698:Analgesia / Q000379:methods; D000772:Anesthesia, Local / Q000379:methods; D019072:Antibiotic Prophylaxis; D000925:Anticoagulants; D001707:Biopsy, Needle / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D000075202:Contraindications; D003666:Decontamination; D005188:False Negative Reactions; D006801:Humans; D008297:Male; D009339:Needles; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D019048:Prostatic Intraepithelial Neoplasia / Q000175:diagnosis / Q000473:pathology; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D017430:Prostate-Specific Antigen