title: Tumor necrosis factor alpha -238G/A (rs 361525) gene polymorphism predicts progression to type-2 diabetes in an Eastern Indian population with prediabetes.
abstract: Prediabetes (IPD; n=122) and normoglycemic individuals (n=100) underwent assessment of polymorphisms of TNFα (-238, -308) and IL6 (-174). After 27.25±5.64 months, 16 IPD had reverted to normoglycemia and 18 progressed to diabetes. TNFα -238AA/GA genotypes were significantly more common in IPD, had higher TNFα, higher progression to diabetes and lower reversal.
authors.affiliation: Department of Endocrinology & Metabolism, IPGMER & SSKM Hospital, 244 AJC Bose Road, Kolkata, India. deepdutta2000@yahoo.com
authors.forename: Deep
authors.initials: D
authors.lastname: Dutta
authors.forename: Subhadip
authors.initials: S
authors.lastname: Choudhuri
authors.forename: Samim Ali
authors.initials: SA
authors.lastname: Mondal
authors.forename: Indira
authors.initials: I
authors.lastname: Maisnam
authors.forename: Abu Hena Hasanoor
authors.initials: AH
authors.lastname: Reza
authors.forename: Sujoy
authors.initials: S
authors.lastname: Ghosh
authors.forename: Subhankar
authors.initials: S
authors.lastname: Chowdhury
authors.forename: Basudev
authors.initials: B
authors.lastname: Bhattacharya
authors.forename: Satinath
authors.initials: S
authors.lastname: Mukhopadhyay
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000235:genetics*; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D020641:Polymorphism, Single Nucleotide; D011236:Prediabetic State / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People
chemical_list: D014409:Tumor Necrosis Factor-alpha