title: Canine splenic haemangiosarcoma: influence of metastases, chemotherapy and growth pattern on post-splenectomy survival and expression of angiogenic factors.
abstract: Splenic haemangiosarcomas (HSAs) from 122 dogs were characterized and classified according to their patterns of growth, survival time post splenectomy, metastases and chemotherapy. The most common pattern of growth was a mixture of cavernous, capillary and solid tumour tissue. Survival time post splenectomy was independent of the growth pattern; however, it was influenced by chemotherapy and metastases. Immunohistochemical assessment of the expression of angiogenic factors (fetal liver kinase-1, angiopoietin-2, angiopoietin receptor-2 and vascular endothelial growth factor A) and conventional endothelial markers (CD31, factor VIII-related antigen) revealed variable expression, particularly in undifferentiated HSAs. Therefore, a combination of endothelial markers should be used to confirm the endothelial origin of splenic tumours.
authors.affiliation: Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, Germany. mariana.goeritz@web.de
authors.forename: M
authors.initials: M
authors.lastname: Göritz
authors.forename: K
authors.initials: K
authors.lastname: Müller
authors.forename: D
authors.initials: D
authors.lastname: Krastel
authors.forename: G
authors.initials: G
authors.lastname: Staudacher
authors.forename: P
authors.initials: P
authors.lastname: Schmidt
authors.forename: M
authors.initials: M
authors.lastname: Kühn
authors.forename: R
authors.initials: R
authors.lastname: Nickel
authors.forename: H-A
authors.initials: HA
authors.lastname: Schoon
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis*; D004283:Dog Diseases / Q000401:mortality / Q000473:pathology*; D004285:Dogs; D005260:Female; D006394:Hemangiosarcoma / Q000098:blood supply / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D009389:Neovascularization, Pathologic / Q000378:metabolism; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000098:blood supply / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor