title: A novel copper(II) mononuclear complex with the non-steroidal anti-inflammatory drug diclofenac: structural characterization and biological activity.
abstract: A copper(II) complex with the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been for the first time synthesized and characterized without any co-organic ligand. Its biological activity against four human cell lines underlined a higher activity of the monomeric complex than the parent molecule in the case of tumoral cell lines. A ternary Cu-diclofenac-albumin complex was suspected to be the reactive species in biological medium.
authors.affiliation: Institut de Chimie Moléculaire de Reims (ICMR, UMR CNRS 7312), Groupe Chimie de Coordination, Université de Reims Champagne-Ardenne, F-51687 Reims Cedex 2, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Sayen
authors.forename: Annie
authors.initials: A
authors.lastname: Carlier
authors.forename: Michel
authors.initials: M
authors.lastname: Tarpin
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Guillon
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004008:Diclofenac / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D004008:Diclofenac; D003300:Copper