title: The anticancer mechanism of caffeic acid phenethyl ester (CAPE): review of melanomas, lung and prostate cancers.
abstract: BACKGROUND
  Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, specifically inhibits NF-κB. It exhibits antioxidant, antiinflammatory, antiproliferative, cytostatic, and most importantly, antineoplastic properties.
  
  
  OBJECTIVE
  The aim of the present mini-review is to summarize and evaluate the anticancer mechanism of CAPE with examples of several cancer types.
  
  
  RESULTS
  In view of the mechanisms and findings in our laboratory and those of others in literature, we suggest that CAPE possess anticancer and apoptosis inducing activities.
  
  
  CONCLUSIONS
  Further researches are needed regarding the anticancer basis of CAPE in all disciplines of medicine. Also, clinical potential toxicities of CAPE should be revealed if it is going to be used as an anticancer agent.
authors.affiliation: Department of Clinical Biochemistry, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Ozturk
authors.forename: Z
authors.initials: Z
authors.lastname: Ginis
authors.forename: S
authors.initials: S
authors.lastname: Akyol
authors.forename: G
authors.initials: G
authors.lastname: Erden
authors.forename: A
authors.initials: A
authors.lastname: Gurel
authors.forename: O
authors.initials: O
authors.lastname: Akyol
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002109:Caffeic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008545:Melanoma / Q000188:drug therapy*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol