title: Uric acid and diabetes: Is there a link?
abstract: Elevated serum uric acid (SUA) levels (i.e. hyperuricaemia) have been associated with metabolic syndrome (MetS) and cardiovascular disease (CVD) morbidity and mortality. Elevated SUA levels predict the onset of type 2 diabetes (T2DM). SUA levels are increased during the early stages of impaired glucose metabolism. Furthermore, in diabetic patients, hyperuricaemia has been linked to both micro- and macrovascular complications. The present review considers: (1) SUA levels in patients with MetS, type 1 diabetes and T2DM; (2) the mechanisms that influence SUA levels in these patients; (3) the potential links between SUA and diabetic complications. The effect on SUA levels of drugs commonly prescribed for T2DM and the risk of uric acid nephrolithiasis in patients with MetS or DM are also briefly discussed.
authors.affiliation: Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Hospital campus, University College London Medical School, University College London, Pond Street, London NW3 2QG, UK.
authors.forename: Niki
authors.initials: N
authors.lastname: Katsiki
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papanas
authors.forename: Vivian A
authors.initials: VA
authors.lastname: Fonseca
authors.forename: Efstratios
authors.initials: E
authors.lastname: Maltezos
authors.forename: Dimitri P
authors.initials: DP
authors.lastname: Mikhailidis
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000209:etiology; D003925:Diabetic Angiopathies / Q000097:blood / Q000150:complications / Q000209:etiology; D058065:Diabetic Cardiomyopathies / Q000097:blood / Q000150:complications / Q000209:etiology; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications / Q000209:etiology; D019317:Evidence-Based Medicine; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000503:physiopathology; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications / Q000209:etiology; D009765:Obesity / Q000150:complications; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid