title: Human monoclonal antibodies in cancer therapy: a review of recent developments.
abstract: In the last decade, phage-display technology for the generation of monoclonal antibodies (mAbs) has improved significantly. Several novel human mAbs directed to a wide range of targets have been generated for the treatment of common malignancies. These targets include antigens associated with apoptosis, angiogenesis and solid tumors, as well as tumor growth-related antigens, insulin-like growth factor I receptor and hepatocyte growth factor. The safety, pharmacokinetics, and pharmacodynamics of several human mAbs have been evaluated in patients with advanced solid tumors. In conclusion, significant advances in the generation and application of human mAbs in cancer therapy have been made in the last decade.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of NanChang University, 330006 Nanchang, Jiangxi, China. xinlindoc@yeah.net
authors.forename: Lin
authors.initials: L
authors.lastname: Xin
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Cao
authors.forename: Hua
authors.initials: H
authors.lastname: Cheng
authors.forename: Fei
authors.initials: F
authors.lastname: Zeng
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Hu
authors.forename: Jianghua
authors.initials: J
authors.lastname: Shao
mesh_terms: D042702:Angiopoietin-2 / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000096:biosynthesis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D017209:Apoptosis / Q000276:immunology; D061505:Cell Surface Display Techniques; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000276:immunology; D017526:Receptor, IGF Type 1 / Q000276:immunology; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000276:immunology; D011993:Recombinant Fusion Proteins / Q000493:pharmacokinetics
chemical_list: D042702:Angiopoietin-2; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; C558733:L19mTNFalpha protein; C493315:PAM-1 monoclonal antibody, human; D011993:Recombinant Fusion Proteins; D017526:Receptor, IGF Type 1; D020796:Receptor, Platelet-Derived Growth Factor alpha; C486839:intetumumab; C507357:mapatumumab