title: Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE.
abstract: Astroglia, the most abundant cells in the human CNS, and even more prominent in multiple sclerosis patients, participate in CNS innate and adaptive immunity, and have been hypothesized to play an important role in multiple sclerosis progression. Experimental autoimmune encephalomyelitis elicited in mice by immunization with myelin oligodendrocyte glycoprotein peptide 35-55 provides a means by which to explore the genesis and disease significance of astrogliosis during a chronic immune-mediated CNS inflammatory/demyelinative disorder that, in its' pathological features, strongly resembles multiple sclerosis.
authors.affiliation: Institute for Pediatric Regenerative Research, UC Davis School of Medicine and Shriners Hospitals for Children Northern California, United States.
authors.forename: Monica
authors.initials: M
authors.lastname: Moreno
authors.forename: Fuzheng
authors.initials: F
authors.lastname: Guo
authors.forename: Emily
authors.initials: E
authors.lastname: Mills Ko
authors.forename: Peter
authors.initials: P
authors.lastname: Bannerman
authors.forename: Athena
authors.initials: A
authors.lastname: Soulika
authors.forename: David
authors.initials: D
authors.lastname: Pleasure
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000276:immunology / Q000502:physiology*; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D005911:Gliosis / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008954:Models, Biological; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments
chemical_list: D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; C445081:myelin oligodendrocyte glycoprotein (35-55)
keywords: Astroglia; Experimental autoimmune encephalomyelitis; Multiple sclerosis