title: Aaptamine derivatives from the Indonesian sponge Aaptos suberitoides.
abstract: Four new aaptamine derivatives (1-4) along with aaptamine (5) and three related compounds (6-8) were isolated from the ethanol extract of the sponge Aaptos suberitoides collected in Indonesia. The structures of the new compounds were unambiguously determined by one- and two-dimensional NMR and by HRESIMS measurements. Compounds 3, 5, and 6 showed cytotoxic activity against the murine lymphoma L5178Y cell line, with IC(50) values ranging from 0.9 to 8.3 μM.
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany.
authors.forename: Cong-Dat
authors.initials: CD
authors.lastname: Pham
authors.forename: Rudolf
authors.initials: R
authors.lastname: Hartmann
authors.forename: Werner E G
authors.initials: WE
authors.lastname: Müller
authors.forename: Nicole
authors.initials: N
authors.lastname: de Voogd
authors.forename: Daowan
authors.initials: D
authors.lastname: Lai
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007214:Indonesia; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D009287:Naphthyridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009287:Naphthyridines; C043986:aaptamine