title: Effects of diets supplemented with MRPs from bread crust on the food intake and body weights in rats.
abstract: Traditionally the effects of dietary Maillard reaction products (MRPs) on food intake and body weight have been described in different studies, but few investigations have been conducted to analyse the main contributors responsible. We studied the effects of long-term consumption of MRPs from bread crust (BC) on rat growth, investigating the efficiency of diet and protein utilization. Different soluble and insoluble fractions of BC were studied to analyse the possible contributors. Additionally, the colour of the faecal material and the amount of fluorescent MRPs in the urine were measured in order to demonstrate MRP excretion. Six groups of rats were fed the following diets for 88 days: control (AIN-93G diet); bread dough (BD) and BC (containing 10% of BD or BC, respectively); low and high molecular weight (LMW-HMW) (containing soluble compounds from BC with <5 kDa and >5 kDa, respectively); insoluble (containing insoluble compounds from BC). Dietary MRPs tended to reduce the food intake and body weight significantly after consumption of more complex compounds (HMW and insoluble). The L*-value in the faeces decreased in animals fed BC and its derivatives, providing evidence of the presence of MRPs. The fluorescence associated with MRP excretion in urine was higher when the LMW diet was consumed, suggesting the easier absorption and clearance of the smaller compounds of BC.
authors.affiliation: Instituto de Nutrición Animal, Estación Experimental del Zaidín (EEZ-CSIC), Camino del Jueves s/n, 18100, Armilla, Granada, Spain. cdelgado@eez.csic.es
authors.forename: Cristina
authors.initials: C
authors.lastname: Delgado-Andrade
authors.forename: Irene
authors.initials: I
authors.lastname: Roncero-Ramos
authors.forename: Ana
authors.initials: A
authors.lastname: Haro
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Morales
authors.forename: Isabel
authors.initials: I
authors.lastname: Seiquer
authors.forename: María Pilar
authors.initials: MP
authors.lastname: Navarro
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001835:Body Weight; D001939:Bread / Q000032:analysis*; D019587:Dietary Supplements / Q000032:analysis*; D004435:Eating; D005243:Feces / Q000737:chemistry; D015416:Maillard Reaction; D023421:Models, Animal; D008970:Molecular Weight; D051381:Rats; D017208:Rats, Wistar; D014908:Triticum / Q000737:chemistry* / Q000378:metabolism