title: Endoreplication.
abstract: Developmentally programmed polyploidy occurs by at least four different mechanisms, two of which (endoreduplication and endomitosis) involve switching from mitotic cell cycles to endocycles by the selective loss of mitotic cyclin-dependent kinase (CDK) activity and bypassing many of the processes of mitosis. Here we review the mechanisms of endoreplication, focusing on recent results from Drosophila and mice.
authors.affiliation: Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany. n.zielke@DKFZ-heidelberg.de
authors.forename: Norman
authors.initials: N
authors.lastname: Zielke
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Edgar
authors.forename: Melvin L
authors.initials: ML
authors.lastname: DePamphilis
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D019927:Cyclin E / Q000378:metabolism / Q000502:physiology; D051357:Cyclin-Dependent Kinase 2 / Q000378:metabolism / Q000502:physiology; D004261:DNA Replication; D004330:Drosophila / Q000166:cytology / Q000235:genetics*; D062951:Endoreduplication / Q000502:physiology*; D051379:Mice; D011123:Polyploidy
chemical_list: D019927:Cyclin E; D051357:Cyclin-Dependent Kinase 2