title: [Surgical treatment of hyperparathyroidism due to parathyroid tumors].
abstract: OBJECTIVE
  To study the clinical features of hyperparathyroidism due to parathyroid tumors, and evaluate the efficiency of surgical management.
  
  
  METHODS
  Twenty-two patients with hyperparathyroidism resulted from parathyroid tumors were reviewed. The age ranged from 32 to 79 years, 9 males and 13 females. Recurrent laryngeal nerve was routinely exposed, and procedures were performed in normal tissue in initial surgery. Additional selective neck dissection of levels II, III, IV, and VI was taken in the cases with recurrent cancer. Local flaps were used to repair the esophageal defects after resecting tumors. The recurrent laryngeal nerves of 4 cases had to be sacrificed because they were embedded in the tumor tissues despite the nerves had normal function before operation. Prophylactic tracheostomy was performed in 5 cases.
  
  
  RESULTS
  Eight cases were identified pathologically as parathyroid carcinoma, of them four with neck metastasis, and 14 cases as parathyroid adenoma after surgery. Their PTH dropped to normal level within two hours after surgery and hypercalcemia disappeared in two days postoperatively. The PTH and serum calcium were in normal range during the follow-up of 12 to 40 months. Recurrence occurred again in two cases in 6 and 8 months after the removal of the recurrent tumor tissues respectively. Esophageal fistula, chylous fistula and dehiscence of sternotomy developed in three cases separately. The tracheostomy was removed in four cases two weeks after operation and in one case six weeks after operation. One patient with parathyroid adenoma died of hypocalcemia about two weeks after operation and another one with recurrent parathyroid carcinoma also died of hypercalcemia 52 months after revised surgery.
  
  
  CONCLUSIONS
  Extended resection of tumor and intraoperative PTH assay were strongly suggested for the managements of both benign and malignant parathyroid tumors.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Beijing Shijitan Hospital, Beijing, China. weibojun1015@sina.com
authors.forename: Bo-jun
authors.initials: BJ
authors.lastname: Wei
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Xing
authors.forename: Guan-sheng
authors.initials: GS
authors.lastname: Tong
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhou
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000209:etiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000150:complications / Q000601:surgery*; D012189:Retrospective Studies; D014139:Tracheostomy
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium