title: Genetic characterization of sapovirus detected in hospitalized children with acute gastroenteritis in Korea.
abstract: BACKGROUND
  Human Caliciviruses, including sapovirus, are important causes of gastroenteritis in children and adults. The present study determined the detection rate of sapovirus (SaV) with acute gastroenteritis in hospitalized children and describes the molecular epidemiology of SaV circulating in Seoul, Korea.
  
  
  METHODS
  In total, 4,583 stool specimens from hospitalized patients with acute gastroenteritis were collected (2,058 females and 2,525 males) in Seoul and were tested for SaVs.
  
  
  CONCLUSIONS
  SaV GI was classified further into two genotypes and GI-1 strains were responsible for two of the cases and GI-2 constituted a further three of the SaV gastroenteritis cases in this study. A phylogenetic analysis of these SaV cases revealed that the GI-1 and GI-2 strains tend to be closely associated with each other and were classified into Asian and European strains. This is the first molecular characterization report of SaV detected in Korea. The GI-1 and GI-2 strains were detected from hospitalized children with acute gastroenteritis.
authors.affiliation: Seoul Metropolitan Government Research Institute of Public Health and Environment, Virus team, 202-3, Yangjae-Dong, Seocho-Gu, Seoul 137-734, Republic of Korea. sanghun93@seoul.go.kr
authors.forename: Sanghun
authors.initials: S
authors.lastname: Park
authors.forename: Seah
authors.initials: S
authors.lastname: Oh
authors.forename: Seokju
authors.initials: S
authors.lastname: Cho
authors.forename: Jibho
authors.initials: J
authors.lastname: Lee
authors.forename: Seunghee
authors.initials: S
authors.lastname: Ryu
authors.forename: Miok
authors.initials: M
authors.lastname: Song
authors.forename: Hyowon
authors.initials: H
authors.lastname: Jung
authors.forename: Sunhee
authors.initials: S
authors.lastname: Park
authors.forename: Gunyong
authors.initials: G
authors.lastname: Park
authors.forename: Sungmin
authors.initials: S
authors.lastname: Choi
authors.forename: Youngzoo
authors.initials: Y
authors.lastname: Chae
authors.forename: Hyunsoo
authors.initials: H
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D001483:Base Sequence; D002648:Child; D017931:DNA Primers; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005759:Gastroenteritis / Q000821:virology*; D006760:Hospitalization; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D056910:Republic of Korea; D029341:Sapovirus / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D017931:DNA Primers