title: Photoresponsive cross-linked polymeric particles for phototriggered burst release.
abstract: We synthesized a series of cross-linked photoresponsive polymeric particles with photolabile monomers and cross-linkers through miniemulsion polymerization. These particles are quite stable in dark, while light irradiation caused the breakage of particles and the efficient release of encapsulated contents up to 95% based on Nile red fluorescence. Photoswitches of particle systems were confirmed by fluorescence spectroscopy, SEM and colorimetry. Particle uptake and triggered release in RAW264.7 cells were confirmed by fluorescein diacetate loaded particles.
authors.affiliation: State Key Laboratory of Natural & Biomimetic drugs, The School of Pharmaceutical Sciences, Peking University, No. 38, Xueyuan Rd., Beijing, 100191, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Lili
authors.initials: L
authors.lastname: Yu
authors.forename: Cong
authors.initials: C
authors.lastname: Lv
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Yedong
authors.initials: Y
authors.lastname: Chen
authors.forename: Xinjing
authors.initials: X
authors.lastname: Tang
mesh_terms: D000818:Animals; D001692:Biological Transport; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004655:Emulsions; D000431:Ethanol / Q000031:analogs & derivatives / Q000737:chemistry; D005452:Fluoresceins; D005456:Fluorescent Dyes; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008689:Methacrylates / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009578:Nitrobenzenes / Q000737:chemistry; D010078:Oxazines; D010316:Particle Size; D058105:Polymerization; D013050:Spectrometry, Fluorescence; D014466:Ultraviolet Rays
chemical_list: D004655:Emulsions; D005452:Fluoresceins; D005456:Fluorescent Dyes; D008689:Methacrylates; D009578:Nitrobenzenes; D010078:Oxazines; C063593:1-(2-nitrophenyl)ethanol; D000431:Ethanol; C044808:nile red; C018506:diacetylfluorescein