title: Synthesis and biological evaluation of noscapine analogues as microtubule-interfering agents.
abstract: A series of noscapine analogues have been synthesized via 13-step reaction starting from 2-hydroxy-3-methoxybenzaldehyde. Anti-tumor activities of these compounds were evaluated against HL-60 cell lines in vitro by the standard MTT assay. It was found that most of these derivatives showed appreciable inhibitory activity against HL-60 and tubulin polymerization. The results also indicated that the potency of compound 31 is about three times more than that ofnoscapine against HL-60 cell line and tubulin polymerization. Moreover, it induced a massive accumulation of cells in G2/M phase. These results showed noscapine and its derivatives were worth to be intensively studied further.
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai, China.
authors.forename: Hou-ling
authors.initials: HL
authors.lastname: Dai
authors.forename: Jian-bin
authors.initials: JB
authors.lastname: Zheng
authors.forename: Min
authors.initials: M
authors.lastname: Lin
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
authors.forename: Fu-sheng
authors.initials: FS
authors.lastname: Zhou
authors.forename: Xiao-chun
authors.initials: XC
authors.lastname: Dong
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Liu
authors.forename: Ren
authors.initials: R
authors.lastname: Wen
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D009665:Noscapine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D058105:Polymerization / Q000187:drug effects; D014404:Tubulin / Q000378:metabolism; D050257:Tubulin Modulators / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D014404:Tubulin; D050257:Tubulin Modulators; D009665:Noscapine