title: Effect of probiotic strains of lacto- and bifidobacteria on the activity of macrophages and other parameters of immunity in cases of staphylococcosis.
abstract: The immunomodulatory properties of Lactobacillus delbrueckii subsp. bulgaricus IMVB-7281, Lactobacillus casei IMV B-7280, Lactobacillus acidophilus IMV B-7279, Bifidobacterium animales VKL and B. animales VKB strains on the models of experimental staphylococcosis infection in mice were determined. It was found that after the mice, infected with staphylococcus, were treated by some probiotic strains of lacto- and bifidobacteria, a normalization of functional activity of phagoctic cells system and increase of the endogenous interferon production were observed. L. delbrueckii subsp. bulgaricus IMVB-7281, L. casei IMVB-7280, L. acidophilus IMV B-7279, B. animales VKB and B. animales VKL are promising for the development of probiotics, effective against staphylococci and for the immunity correction.
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Acad. Zabolotny St.. Kyiv, MSP, D03680, Ukraine.
authors.forename: V V
authors.initials: VV
authors.lastname: Mokrozub
authors.forename: L M
authors.initials: LM
authors.lastname: Lazarenko
authors.forename: L P
authors.initials: LP
authors.lastname: Babenko
authors.forename: L M
authors.initials: LM
authors.lastname: Shynkarenko-Sichel
authors.forename: Z M
authors.initials: ZM
authors.lastname: Olevinska
authors.forename: N O
authors.initials: NO
authors.lastname: Timoshok
authors.forename: V S
authors.initials: VS
authors.lastname: Pidgorskyi
authors.forename: M Y
authors.initials: MY
authors.lastname: Spivak
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000898:Antibiosis; D001644:Bifidobacterium / Q000502:physiology*; D002452:Cell Count; D005260:Female; D056747:Immunomodulation / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007372:Interferons / Q000096:biosynthesis / Q000276:immunology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007779:Lactobacillus acidophilus / Q000502:physiology*; D007780:Lacticaseibacillus casei / Q000502:physiology*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010537:Peritoneum / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D019936:Probiotics / Q000008:administration & dosage / Q000627:therapeutic use*; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D013210:Staphylococcus / Q000187:drug effects
chemical_list: D007372:Interferons