title: Enaminonitriles in heterocyclic synthesis: a route to 1,3-diaryl-4-aminopyrazole derivatives.
abstract: Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the Thorpe-Ziegler cyclization.
authors.affiliation: Department of Chemistry, Sciences faculty for Girls, King AbdulAziz University, Jeddah, P.O. Box 13343, Jeddah 21493, Saudi Arabia.
authors.forename: Hanadi Y
authors.initials: HY
authors.lastname: Medrasi
authors.forename: Mariam Abdullah
authors.initials: MA
authors.lastname: Al-Sheikh
authors.forename: Abdellatif Mohamed
authors.initials: AM
authors.lastname: Salaheldin
mesh_terms: D000181:Acrylonitrile / Q000031:analogs & derivatives / Q000138:chemical synthesis; D000478:Alkylation; D003500:Cyclization; D003979:Diazonium Compounds / Q000737:chemistry; D004126:Dimethylformamide / Q000737:chemistry; D005561:Formates / Q000737:chemistry; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry*; D008872:Microwaves; D009570:Nitriles / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry
chemical_list: D003979:Diazonium Compounds; D005561:Formates; D006574:Heterocyclic Compounds, 2-Ring; D009570:Nitriles; D010880:Piperidines; D011720:Pyrazoles; D012997:Solvents; C547711:enaminonitrile; C032727:piperidine; D004126:Dimethylformamide; D000181:Acrylonitrile