title: Ovarian cancer as a genetic disease.
abstract: Ovarian cancer is characterized by the highest mortality rate among gynecologic malignancies. Therefore, there is a growing need for innovative therapies and techniques for monitoring and prevention of this disease. The exact cause of most ovarian tumors usually remains unknown. Ovarian cancer is believed to be caused by a range of different variables. This review is an attempt to summarize some genetic factors involved in the disruption of certain signaling pathways responsible for ovarian tumor transformation and development. Those factors considerably contribute to accurate diagnostics, treatment and prognosis in ovarian cancer.
authors.affiliation: Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Lech
authors.forename: Teodora
authors.initials: T
authors.lastname: Daneva
authors.forename: Shina
authors.initials: S
authors.lastname: Pashova
authors.forename: Hristo
authors.initials: H
authors.lastname: Gagov
authors.forename: Robert
authors.initials: R
authors.lastname: Crayton
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kukwa
authors.forename: Anna M
authors.initials: AM
authors.lastname: Czarnecka
authors.forename: Cezary
authors.initials: C
authors.lastname: Szczylik
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005260:Female; D019398:Genes, BRCA1 / Q000502:physiology; D024522:Genes, BRCA2 / Q000502:physiology; D016158:Genes, p53 / Q000502:physiology; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics*; D011379:Prognosis; D015398:Signal Transduction / Q000235:genetics