title: Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324.
abstract: Seven lanostane triterpenoids, ganorbiformins A-G, together with twelve known compounds, were isolated from cultures of the mushroom fungus Ganoderma orbiforme BCC 22324. Ganorbiformin A is an unusual rearranged analog, whereas the other compounds share the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T also exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra (MIC 1.3 μM).
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani 12120, Thailand. isaka@biotec.or.th
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
authors.forename: Panida
authors.initials: P
authors.lastname: Chinthanom
authors.forename: Surisa
authors.initials: S
authors.lastname: Kongthong
authors.forename: Kitlada
authors.initials: K
authors.lastname: Srichomthong
authors.forename: Rattaket
authors.initials: R
authors.lastname: Choeyklin
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes