title: [Effect of immobilization-painful stress on cardiac ino- and chronotropic functions of animals under the conditions of nitric oxide synthesis supression].
abstract: In experiments on female rats it has been shown that the blockade of nitric oxide synthesis by the intraperitoneal administration of NO-synthase non-selective inhibitor nitro-L-arginine at the dose of 10 mg/kg before and after stress (produced by 6, or 12, or 24 h immobilization with painful stimulus) results in the decrease of cardiac ino- and chronotropic functions. In carrying out stress tests (the tests of adrenoreactivity and maximum isometric workload) a considerable decrease in increment of myocardial contractility findings and frequency of heart contractions has been found in animals after 6, 12, 24 h stress under the conditions of nitric oxide synthesis suppression in comparison to stressed animals of control group.
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: N V
authors.initials: NV
authors.lastname: Arsenova
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007103:Immobilization; D007274:Injections, Intraperitoneal; D009200:Myocardial Contraction / Q000187:drug effects*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D019335:Nitroarginine / Q000494:pharmacology*; D010146:Pain; D010507:Periodicity; D051381:Rats; D013312:Stress, Physiological
chemical_list: D019335:Nitroarginine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D004837:Epinephrine