title: Vitamin D concentration and lateral cerebral ventricle volume in older adults.
abstract: METHODS
  Vitamin D deficiency is associated with an enlargement of the lateral cerebral ventricles in rodents. The effect of low serum 25-hydroxyvitamin D (25OHD) on lateral cerebral ventricle volume has not been studied yet in humans. The purpose of this cross-sectional study was to determine whether vitamin D deficiency was associated with greater lateral cerebral ventricle volume in older adults.
  
  
  RESULTS
  Ninety-two Caucasian community-dwellers with no clinical hydrocephalus (mean, 72.2 ± 6.2 years; 46.7% female) were divided into two groups according to serum 25OHD concentration (deficiency ≤ 50 nmol/L; normal > 50 nmol/L). Cerebral ventricular volume was quantified using semi-automated software from three-dimensional T1-weighted MRI. Age, gender, body mass index, blood pressure, education level, Mini-Mental State Examination, white matter lesions, and serum calcium concentrations were used as covariates. There was an inverse linear association between 25OHD concentration and ventricular volume (p = 0.049). Compared to individuals with normal 25OHD, those with 25OHD deficiency (n = 33) had 28% larger lateral ventricles (46.9 ± 26.8 mL versus 36.6 ± 16.4 mL, p = 0.026). Vitamin D deficiency was associated with an increase in ventricular volume (adjustedβ = 16.55, p = 0.023). The ventricular enlargement involved ventricle bodies (p = 0.025) but not temporal horns (p = 0.112).
  
  
  CONCLUSIONS
  Serum 25OHD deficiency was associated with larger lateral cerebral ventricles. These findings provide a scientific base for vitamin D replacement trials.
authors.affiliation: Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, University Memory Clinic of Angers, UPRES EA 4638, University of Angers, UNAM, Angers, France. CeAnnweiler@chu-angers.fr
authors.forename: Cédric
authors.initials: C
authors.lastname: Annweiler
authors.forename: Manuel
authors.initials: M
authors.lastname: Montero-Odasso
authors.forename: Vladimir
authors.initials: V
authors.lastname: Hachinski
authors.forename: Sudha
authors.initials: S
authors.lastname: Seshadri
authors.forename: Robert
authors.initials: R
authors.lastname: Bartha
authors.forename: Olivier
authors.initials: O
authors.lastname: Beauchet
mesh_terms: D000368:Aged; D002136:Calcium, Dietary / Q000097:blood; D002552:Cerebral Ventricles / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications; D044465:White People
chemical_list: D002136:Calcium, Dietary; D014807:Vitamin D