title: Left-sided portal hypertension secondary to pancreatic cancer: clinical features, surgical treatment and outcome of 48 cases.
abstract: OBJECTIVE
  Features of LSPH secondary to pancreatic cancer is ambiguous, and controversy remains in the treatment.
  
  
  METHODS
  48 cases from our department were retrospectively analyzed to evaluate the clinical features, as well as the feasibility and effect of surgical treatment.
  
  
  RESULTS
  16 patients had gastrointestinal hemorrhage history. Laboratory findings showed normocytic and normochromic anemia, thrombocytopenia, lymphocyte reduction, and elevated liver enzyme. Tumor markers were normal in 12 patients. Ultrasonography showed splenic venous obstruction in 40 patients and splenomegaly in 35. Esophagogastric varices could be detected by endoscopy in 40 patients and by CT in 37. Radical resection was performed in 43 patients and splenectomy or additional devascularization in 29. 15 patients had gastrointestinal bleeding during follow-up, and the median survival time was 11.0 months.
  
  
  CONCLUSIONS
  Associated LSPH brought special features to pancreatic cancer. Radical resection, as well as splenectomy or additional devascularization for varices above Grade II, was worth performing.
authors.forename: Kong
authors.initials: K
authors.lastname: Yalin
authors.forename: Zhang
authors.initials: Z
authors.lastname: Hongyi
authors.forename: He
authors.initials: H
authors.lastname: Xiaojun
authors.forename: Liu
authors.initials: L
authors.lastname: Chengli
authors.forename: Xiao
authors.initials: X
authors.lastname: Mei
authors.forename: Wu
authors.initials: W
authors.lastname: Di
authors.forename: Zhao
authors.initials: Z
authors.lastname: Gang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yuying
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D003952:Diagnostic Imaging; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor