title: Targeting matrix metalloproteinases: design of a bifunctional inhibitor for presentation by tumour-associated galectins.
abstract: A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time.
authors.affiliation: Department of Chemistry, University of Florence, Via della Lastruccia, 13 50019 Sesto F.no Firenze, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Bartoloni
authors.forename: Blanca E
authors.initials: BE
authors.lastname: Domínguez
authors.forename: Elisa
authors.initials: E
authors.lastname: Dragoni
authors.forename: Barbara
authors.initials: B
authors.lastname: Richichi
authors.forename: Marco
authors.initials: M
authors.lastname: Fragai
authors.forename: Sabine
authors.initials: S
authors.lastname: André
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Gabius
authors.forename: Ana
authors.initials: A
authors.lastname: Ardá
authors.forename: Claudio
authors.initials: C
authors.lastname: Luchinat
authors.forename: Jesús
authors.initials: J
authors.lastname: Jiménez-Barbero
authors.forename: Cristina
authors.initials: C
authors.lastname: Nativi
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D037161:Galectins / Q000737:chemistry* / Q000378:metabolism*; D006001:Glycoconjugates / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D037102:Lectins / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D061965:Matrix Metalloproteinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D020782:Matrix Metalloproteinases / Q000737:chemistry* / Q000378:metabolism*; D009369:Neoplasms; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D004791:Enzyme Inhibitors; D037161:Galectins; D006001:Glycoconjugates; D037102:Lectins; D008024:Ligands; D061965:Matrix Metalloproteinase Inhibitors; C583689:NNGH compound; D013449:Sulfonamides; D020782:Matrix Metalloproteinases