title: [Cellular ESCRT complex and its roles in enveloped viruses budding].
abstract: In eukaryotic cells, multivesicular bodies (MVBs) are required for trafficking of membrane proteins to lysosomes for selective destruction. The sorting of ubiquitylated membrane proteins into multivesicular bodies and the biogenesis of MVBs are mediated by the endosomal sorting complex required for transport (ESCRT). Topologically equivalent to the budding of intralumenal vesicles from the limiting membrane of the MVBs, the ESCRT complex is also involved in cytokinetic abscission, phagophore formation, and enveloped virus budding. Many retroviruses and RNA viruses encode "late-domain" motifs that are able to interact with the components of the ESCRT complex, and the interactions recruit ESCRT-III and VPS4 to the viral assembly and budding sites. Recently, few studies revealed that the ESCRT complex is also required for efficient egress of some DNA viruses, including Hepatitis B, Herpes simplex virus type-1, and Autographa californica multiple nucleopolyhedrovirus. Further examination of virus-ESCRT interactions should shed light on the detailed mechanism of virus assembly and budding.
authors.affiliation: State Key Laboratory for Crop Stress Biology in Arid Areas, MOA Key Laboratory of Integrated Pest Management on the Northwest Loess Plateau, College of Plant Protection, NorthwestA&F University, Yangling 712100, Shaanxi, China. zhaofei_li@yahoo.com.cn
authors.forename: Zhaofei
authors.initials: Z
authors.lastname: Li
authors.forename: Honggang
authors.initials: H
authors.lastname: Tian
authors.forename: Tongxian
authors.initials: T
authors.lastname: Liu
mesh_terms: D056827:Endosomal Sorting Complexes Required for Transport / Q000502:physiology*; D006801:Humans; D014759:Viral Envelope Proteins / Q000378:metabolism*; D019065:Virus Assembly; D018406:Virus Physiological Phenomena; D057074:Virus Release; D014780:Viruses / Q000254:growth & development
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D014759:Viral Envelope Proteins