title: Association of cardiovascular response to an acute resistance training session with the ACE gene polymorphism in sedentary women: a randomized trial.
abstract: BACKGROUND
  The aim of the present study was to verify the effects of an acute resistance training (RT) session and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) on systolic (SBP), diastolic (DBP) and mean blood pressure (MBP), and heart rate (HR).
  
  
  METHODS
  The sample consisted of 27 sedentary women (33.3 ± 8.2 yrs; 69.1 ± 13.8 kg; 1.57 ± 0.05 m; 27.6 ± 5.1 kg/m2) divided into two groups according to their polymorphism I/D (DD = 9; II + ID = 18). Volunteers underwent two experimental sessions: RT - an acute session performed with three sets at 60% of one-repetition maximum (1RM) interspersed with 1 minute rest interval between exercises and sets, and a control session (CON) in which they remained seated for 30 minutes in the laboratory. SBP, DBP, MBP and HR were measured before exercise and during one hour every 10 minutes after sessions, in the seated position. A two-way ANOVA for repeated measures with Tukey's post hoc test was used for the intra and inter-group comparisons.
  
  
  RESULTS
  There were no statistically significant differences on SBP, DBP and MBP after the experimental protocols, and no effect of ACE polymorphism (P > 0.05). However, comparing CON versus exercise effect size values (ES), homozygotic carriers of the allele D presented a drop in SBP which was considered moderate, while in allele I carriers it was small, 30 minutes after exercise. In MBP, homozygotic D carriers exhibited a large ES 20 minutes post-exercise. HR was higher at 10, 20 and 30 minutes after exercise as compared to pre-exercise only for carriers of the I allele (  < 0.05).
  
  
  CONCLUSIONS
  Therefore, an acute RT session reduces clinical BP. In addition to this; it seems that ACE polymorphism had some influence on cardiovascular response to exercise.
  
  
  BACKGROUND
  RBR-6GDYVZ.
authors.affiliation: Graduation Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil. jessica.cardozzo@gmail.com
authors.forename: Jéssica Cardoso
authors.initials: JC
authors.lastname: de Souza
authors.forename: Ramires Alsamir
authors.initials: RA
authors.lastname: Tibana
authors.forename: Nuno Manuel Frade
authors.initials: NM
authors.lastname: de Sousa
authors.forename: Vinícius Carolino
authors.initials: VC
authors.lastname: de Souza
authors.forename: Margô G O
authors.initials: MG
authors.lastname: Karnikowski
authors.forename: Jonato
authors.initials: J
authors.lastname: Prestes
authors.forename: Carmen Silvia Grubert
authors.initials: CS
authors.lastname: Campbell
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000235:genetics*; D001938:Brazil; D005260:Female; D006339:Heart Rate / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D055070:Resistance Training; D057185:Sedentary Behavior; D013997:Time Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A