title: Improved high-fat diet-induced glucose intolerance by an oral administration of phytosphingosine.
abstract: We have previously reported that phytoceramide and phytosphingosine (PHS) stimulated the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in cells. PPARγ is a therapeutic target for type 2 diabetes. We found in this study that an oral administration of PHS improved diet-induced glucose intolerance in mice. Since PHS is highly expressed in yeast, PHS in fermented foods may improve diabetes.
authors.affiliation: Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Itsuo
authors.initials: I
authors.lastname: Murakami
authors.forename: Susumu
authors.initials: S
authors.lastname: Mitsutake
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Junko
authors.initials: J
authors.lastname: Matsuda
authors.forename: Akemi
authors.initials: A
authors.lastname: Suzuki
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Shigyo
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Igarashi
mesh_terms: D052242:Adiponectin / Q000235:genetics / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002518:Ceramides / Q000008:administration & dosage*; D018932:Chemokine CCL2 / Q000235:genetics / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000209:etiology / Q000378:metabolism*; D059305:Diet, High-Fat / Q000009:adverse effects; D015870:Gene Expression; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000517:prevention & control; D005951:Glucose Tolerance Test; D007421:Intestine, Small / Q000737:chemistry / Q000378:metabolism*; D008099:Liver / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009097:Multienzyme Complexes / Q000172:deficiency / Q000235:genetics; D010088:Oxidoreductases / Q000172:deficiency / Q000235:genetics; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D013110:Sphingosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D052242:Adiponectin; C491768:Ccl2 protein, mouse; D002518:Ceramides; D018932:Chemokine CCL2; D009097:Multienzyme Complexes; D047495:PPAR gamma; D014409:Tumor Necrosis Factor-alpha; C489141:Degs2 protein, mouse; D010088:Oxidoreductases; C012491:phytosphingosine; D005947:Glucose; D013110:Sphingosine