title: Sudden renal function deterioration in an elderly patient on vancomycin therapy for endocarditis.
abstract: Vancomycin is currently the drug of choice in meticillin-resistant Staphylococcus aureus (MRSA) infection. It is also used prophylactically in some situations in which the patient is at risk for endocarditis. It is often used in combination with other antibacterials in the treatment of endocarditis and is a potential nephrotoxin. Various consensus guidelines differ in their interpretation of vancomycin plasma concentrations. This paper describes a case of a 72-years old Caucasian female patient, who developed significant renal impairment when prescribed vancomycin in combination with penicillin for the treatment of endocarditis, caused by Streptococcus pneumoniae.
authors.affiliation: Department of Medical and Clinical Biochemistry, Division of Clinical of Pahrmacology, Faculty Hopsital Motol, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic. hundie.tesfaye@fnmotol.cz
authors.forename: Hundie
authors.initials: H
authors.lastname: Tesfaye
authors.forename: Jiřina
authors.initials: J
authors.lastname: Lukášková
authors.forename: Jana
authors.initials: J
authors.lastname: Hořínková
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004696:Endocarditis / Q000188:drug therapy*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D014640:Vancomycin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin