title: Analogues of oxy-heme Aβ: reactive intermediates relevant to Alzheimer's disease.
abstract: Redox active metals (Fe and Cu) and cofactors (heme) bind to Aβ peptides and react with O(2) in their reduced state leading to oxidative stress in the brain. In this study we cryogenically trap and characterize a Fe-O(2) intermediate, using resonance Raman spectroscopy, involved in reactive oxygen species formation by Aβ peptides. This is the first reaction intermediate relevant to Alzheimer's disease to be reported.
authors.affiliation: Indian Association for the Cultivation of Science, Department of Inorganic Chemistry, 2A & 2B, Raja S. C.Mullick Road, Jadavpur, Kolkata, 700032, India.
authors.forename: Manas
authors.initials: M
authors.lastname: Seal
authors.forename: Soumya
authors.initials: S
authors.lastname: Mukherjee
authors.forename: Debajyoti
authors.initials: D
authors.lastname: Pramanik
authors.forename: Kaustuv
authors.initials: K
authors.lastname: Mittra
authors.forename: Abhishek
authors.initials: A
authors.lastname: Dey
authors.forename: Somdatta Ghosh
authors.initials: SG
authors.lastname: Dey
mesh_terms: D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D006418:Heme / Q000737:chemistry*; D007501:Iron / Q000737:chemistry; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D006418:Heme; D007501:Iron; D010100:Oxygen