title: Antioxidant activities of thiosemicarbazones from substituted benzaldehydes and N-(tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazide.
abstract: Reaction of N-(2,3,4,6-tetra-O-acetyl-β-d-galactopyranosyl)thiosemicarbazide and different substituted benzaldehydes gave some new substituted benzaldehyde N-(2,3,4,6-tetra-O-acetyl-β-d-galactopyranosyl)thiosemicarbazones. The reaction was performed using conventional and microwave-assisted heating methods. The structures of thiosemicarbazones were confirmed by spectroscopic (IR, (1)H NMR, (13)C NMR and ESI-MS) method. The antioxidant activity of these thiosemicarbazones was evaluated in vitro and in vivo, and it's shown that some of these compounds had significant antioxidant activity. Amongst the compounds screened for antioxidant activity, thiosemicarbazones 4a, 4b and 4c showed good antioxidant activity on DPPH. The compounds 4g, 4i, 4l caused significant elevation of SOD activity and 4e, 4g, 4i, 4l had higher catalase activity, and only compounds 4c and 4f expressed the GSH-Px activity.
authors.affiliation: Faculty of Chemistry, VNU University of Science, Ha Noi 10000, Viet Nam. nguyendinhthanh@hus.edu.vn
authors.forename: Dinh Thanh
authors.initials: DT
authors.lastname: Nguyen
authors.forename: The Hoai
authors.initials: TH
authors.lastname: Le
authors.forename: Thi Thu Trang
authors.initials: TT
authors.lastname: Bui
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D001547:Benzaldehydes / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry*; D005697:Galactosides / Q000737:chemistry*; D015394:Molecular Structure; D010851:Picrates / Q000138:chemical synthesis / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012663:Semicarbazides / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001547:Benzaldehydes; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005697:Galactosides; D010851:Picrates; D012663:Semicarbazides; D013882:Thiosemicarbazones; C004931:1,1-diphenyl-2-picrylhydrazyl