title: Progenitor programming in mammalian nephrogenesis.
abstract: Nephrogenesis is dependent on the input of several transcriptional regulatory networks. However, the details of how these networks operate and converge to facilitate nephron progenitor specific programmes are largely unknown. To this end, recent studies have focused on identifying the precise regulatory mechanisms that modulate progenitor maintenance and induction. Continued focus on this area of research will help identify nephrogenic programmes which could be manipulated for therapeutic intervention of kidney disease.
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad-CIRM Center for Regenerative Medicine and Stem Cell Research, WM Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
authors.forename: Lori L
authors.initials: LL
authors.lastname: O'Brien
authors.forename: Andrew P
authors.initials: AP
authors.lastname: McMahon
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009399:Nephrons / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D038081:Organogenesis; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors