title: Incidence, predictors, origin and prevention of early and late neurological events after transcatheter aortic valve implantation (TAVI): a comprehensive review of current data.
abstract: Transcatheter aortic valve implantation (TAVI) is a novel treatment option for patients with severe, symptomatic aortic valve stenosis considered inoperable or at high risk for surgical aortic valve replacement. Despite rapid adoption of this technology into clinical application, however, recent randomized controlled clinical trials have raised safety concerns regarding an increased risk of neurological events with TAVI compared to both medical treatment and conventional, surgical aortic valve replacement. Moreover, neuro-imaging studies have revealed an even higher incidence of new, albeit clinically silent cerebral lesions as a surrogate for procedural embolization. In this article, we review currently available data on the incidence, timing, predictors, prognostic implications and potential mechanisms of neurological events after TAVI.
authors.affiliation: Department of Cardiology, West-German Heart Center Essen, Essen University Hospital, University Duisburg-Essen, Hufelandstr.55, 45122, Essen, Germany. philipp.kahlert@uk-essen.de
authors.forename: Philipp
authors.initials: P
authors.lastname: Kahlert
authors.forename: Fadi
authors.initials: F
authors.lastname: Al-Rashid
authors.forename: Björn
authors.initials: B
authors.lastname: Plicht
authors.forename: Heike
authors.initials: H
authors.lastname: Hildebrandt
authors.forename: Polykarpos
authors.initials: P
authors.lastname: Patsalis
authors.forename: Karim El
authors.initials: KE
authors.lastname: Chilali
authors.forename: Daniel
authors.initials: D
authors.lastname: Wendt
authors.forename: Matthias
authors.initials: M
authors.lastname: Thielmann
authors.forename: Lars
authors.initials: L
authors.lastname: Bergmann
authors.forename: Eva
authors.initials: E
authors.lastname: Kottenberg
authors.forename: Marc
authors.initials: M
authors.lastname: Schlamann
authors.forename: Holger
authors.initials: H
authors.lastname: Eggebrecht
authors.forename: Heinz
authors.initials: H
authors.lastname: Jakob
authors.forename: Gerd
authors.initials: G
authors.lastname: Heusch
authors.forename: Thomas
authors.initials: T
authors.lastname: Konorza
authors.forename: Raimund
authors.initials: R
authors.lastname: Erbel
mesh_terms: D001024:Aortic Valve Stenosis / Q000453:epidemiology / Q000628:therapy*; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D006350:Heart Valve Prosthesis; D006801:Humans; D020766:Intracranial Embolism / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic