title: [Expressions of EZH2 and RUNX3 in renal cell carcinoma and their clinical significance].
abstract: OBJECTIVE
  To investigate the expression levels of enhancer of zeste homolog 2 (EZH2) and human runt-related transcription factor 3 (RUNX3) in renal cell carcinoma (RCC), and analyze their clinical significance and expression correlation.
  
  
  METHODS
  Expressions of EZH2 and RUNX3 proteins were analyzed by immunohistochemistry in 56 RCC tissues and corresponding adjacent normal renal tissues, respectively. Statistic analysis was conducted using SPSS17.0 software.
  
  
  RESULTS
  Immunohistochemistry revealed that the positive rates of EZH2 and RUNX3 expressions were 67.9% and 37.5% in RCC tissues, respectively, and they were 28.6% and 67.3% in adjacent normal renal tissues. The expressions of EZHZ and RUNX3 between RCC and normal renal tissues were significantly different (P<0.05). High expression of EZH2 and low expression of RUNX3 in RCC were associated with the clinical stage (P<0.05), but not associated with pathological differentiation, age or gender (P>0.05). No statistically significant negative correlation was observed in the expressions of EZH2 and RUNX3 in RCC (P>0.05).
  
  
  CONCLUSIONS
  Both EZH2 and RUNX3 may play important roles in the development and progression of RCC, and the detection on EZH2 and RUNX3 expressions will be helpful for early diagnosis and prognosis prediction of RCC.
authors.affiliation: Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. wangguodong021014@163.com
authors.forename: Guodong
authors.initials: G
authors.lastname: Wang
authors.forename: Weijun
authors.initials: W
authors.lastname: Qin
authors.forename: Jia
authors.initials: J
authors.lastname: Zheng
authors.forename: Ming
authors.initials: M
authors.lastname: Wei
authors.forename: Xingchun
authors.initials: X
authors.lastname: Zhou
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: Weihong
authors.initials: W
authors.lastname: Wen
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D050677:Core Binding Factor Alpha 3 Subunit / Q000235:genetics / Q000378:metabolism*; D000071221:Enhancer of Zeste Homolog 2 Protein; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D063151:Polycomb Repressive Complex 2 / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis
chemical_list: D050677:Core Binding Factor Alpha 3 Subunit; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; D063151:Polycomb Repressive Complex 2