title: One-step photo synthesis of protein-drug nanoassemblies for drug delivery.
abstract: Upon controlled UV illumination, disulfide bonds in bovine α-lactalbumin (BLA) are selectively broken, leading to self-assembly of the BLA and doxorubicin (DOX) molecules into nanoparticles via hydrophobic interactions and intermolecular disulfide bonds. Such protein-drug nanoparticles have synergistic anticancer activity in vitro and tumor-homing specificity in vivo, which are of great potential for systemic drug delivery in cancer therapy.
authors.affiliation: National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing 210093, PR China.
authors.forename: Jinbing
authors.initials: J
authors.lastname: Xie
authors.forename: Yi
authors.initials: Y
authors.lastname: Cao
authors.forename: Mao
authors.initials: M
authors.lastname: Xia
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.forename: Meng
authors.initials: M
authors.lastname: Qin
authors.forename: Jiwu
authors.initials: J
authors.lastname: Wei
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D007768:Lactalbumin / Q000008:administration & dosage* / Q000737:chemistry; D008027:Light; D051379:Mice; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry* / Q000528:radiation effects; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology*; D019301:Oleic Acid / Q000008:administration & dosage* / Q000737:chemistry; D010777:Photochemistry / Q000379:methods; D016896:Treatment Outcome
chemical_list: C560443:BAMLET complex, Bos taurus; D053769:Nanocapsules; D019301:Oleic Acid; D004317:Doxorubicin; D007768:Lactalbumin