title: Targeting cancer cells with controlled release nanocapsules based on a single aptamer.
abstract: Molecular gates have received considerable attention as drug delivery systems. More recently, aptamer-based gates showed great potential in overcoming major challenges associated with drug delivery by means of nanocapsules. Based on a switchable aptamer nanovalves approach, we herein report the first demonstration of an engineered single molecular gate that directs nanoparticles to cancer cells and subsequently delivers the payload in a controllable fashion.
authors.affiliation: Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA 52242, USA.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Hernandez
authors.forename: Luiza I
authors.initials: LI
authors.lastname: Hernandez
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pinto
authors.forename: Thomas
authors.initials: T
authors.lastname: Schäfer
authors.forename: Veli C
authors.initials: VC
authors.lastname: Özalp
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations; D019793:Fluorescein / Q000737:chemistry; D006801:Humans; D055029:Inverted Repeat Sequences; D008958:Models, Molecular; D053769:Nanocapsules / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D010750:Phosphoproteins / Q000378:metabolism; D016062:Porosity; D016601:RNA-Binding Proteins / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry; D000097796:Nucleolin
chemical_list: D052157:Aptamers, Nucleotide; D003692:Delayed-Action Preparations; D019793:Fluorescein; D053769:Nanocapsules; D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D012822:Silicon Dioxide; D000097796:Nucleolin