title: Some case studies on application of "r(m)2" metrics for judging quality of quantitative structure-activity relationship predictions: emphasis on scaling of response data.
abstract: Quantitative structure-activity relationship (QSAR) techniques have found wide application in the fields of drug design, property modeling, and toxicity prediction of untested chemicals. A rigorous validation of the developed models plays the key role for their successful application in prediction for new compounds. The r(m)(2) metrics introduced by Roy et al. have been extensively used by different research groups for validation of regression-based QSAR models. This concept has been further advanced here with introduction of scaling of response data prior to computation of r(m)(2). Further, a web application (accessible from http://aptsoftware.co.in/rmsquare/ and http://203.200.173.43:8080/rmsquare/) for calculation of the r(m)(2) metrics has been introduced here. The present study reports that the web application can be easily used for computation of r(m)(2) metrics provided observed and QSAR-predicted data for a set of compounds are available. Further, scaling of response data is recommended prior to r(m)(2) calculation.
authors.affiliation: Drug Theoretics and Cheminformatics Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India. kunalroy_in@yahoo.com
authors.forename: Kunal
authors.initials: K
authors.lastname: Roy
authors.forename: Pratim
authors.initials: P
authors.lastname: Chakraborty
authors.forename: Indrani
authors.initials: I
authors.lastname: Mitra
authors.forename: Probir Kumar
authors.initials: PK
authors.lastname: Ojha
authors.forename: Supratik
authors.initials: S
authors.lastname: Kar
authors.forename: Rudra Narayan
authors.initials: RN
authors.lastname: Das
mesh_terms: D015195:Drug Design; D008958:Models, Molecular; D008962:Models, Theoretical; D021281:Quantitative Structure-Activity Relationship