title: Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.
abstract: Due to the emergence of drug-resistant strains and the cumulative toxicities associated with current therapies, demand remains for new inhibitors of HIV-1 replication. The HIV-1 matrix (MA) protein is an essential viral component with established roles in the assembly of the virus. Using virtual and surface plasmon resonance (SPR)-based screening, we describe the identification of the first small molecule to bind to the HIV-1 MA protein and to possess broad range anti-HIV properties.
authors.affiliation: Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA 19102, USA.
authors.forename: Isaac
authors.initials: I
authors.lastname: Zentner
authors.forename: Luz-Jeannette
authors.initials: LJ
authors.lastname: Sierra
authors.forename: Lina
authors.initials: L
authors.lastname: Maciunas
authors.forename: Andrei
authors.initials: A
authors.lastname: Vinnik
authors.forename: Peter
authors.initials: P
authors.lastname: Fedichev
authors.forename: Marie K
authors.initials: MK
authors.lastname: Mankowski
authors.forename: Roger G
authors.initials: RG
authors.lastname: Ptak
authors.forename: Julio
authors.initials: J
authors.lastname: Martín-García
authors.forename: Simon
authors.initials: S
authors.lastname: Cocklin
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D058990:Molecular Targeted Therapy; D020349:Surface Plasmon Resonance; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000378:metabolism*
chemical_list: D019380:Anti-HIV Agents; D054301:gag Gene Products, Human Immunodeficiency Virus