title: Erythropoietin and autoimmune neuroinflammation: lessons from experimental autoimmune encephalomyelitis and experimental autoimmune neuritis.
abstract: Erythropoietin (EPO) is known to have numerous biological functions. While its primary function is during haematopoiesis, recent studies have shown that EPO plays important role in cytoprotection, immunomodulation, and antiapoptosis. These secondary functions of EPO are integral to tissue protection following hypoxic injury, ischemia-reperfusion injury, and spinal cord injury in the central nervous system. This review focuses on experimental evidence documenting the neuroprotective effects of EPO in organ-specific autoimmune nervous system disorders such as experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN). In addition, the immunomodulatory role of EPO in the pathogenesis of EAE and EAN animal models of human multiple sclerosis and Guillain-Barré syndrome, respectively, will be discussed.
authors.affiliation: Department of Veterinary Anatomy, Veterinary Medical Research Institute, College of Veterinary Medicine, Jeju National University, Jeju, Korea.
authors.forename: Taekyun
authors.initials: T
authors.lastname: Shin
authors.forename: Meejung
authors.initials: M
authors.lastname: Ahn
authors.forename: Changjong
authors.initials: C
authors.lastname: Moon
authors.forename: Seungjoon
authors.initials: S
authors.lastname: Kim
keywords: Autoimmune diseases; Encephalomyelitis; Erythropoietin; Experimental autoimmune neuritis; Neuroinflammation; Neuroprotection