title: Characterization of chitosan-magnesium aluminum silicate nanocomposite films for buccal delivery of nicotine.
abstract: The objective of this study was to prepare and characterize chitosan-magnesium aluminum silicate (CS-MAS) nanocomposite films as a buccal delivery system for nicotine (NCT). The effects of the CS-MAS ratio on the physicochemical properties, release and permeation, as well as on the mucoadhesive properties, were investigated. Molecular interactions between the components of the film were also investigated. The results indicated that NCT-loaded CS-MAS films provided a higher NCT content than NCT-loaded films containing only CS. The greater the MAS ratio in the films, the higher the NCT content that was observed because intercalated nanocomposites could be formed by electrostatic interactions of MAS with NCT and CS. These interactions caused an insignificant loss of NCT by evaporation during film drying. The release and permeation of NCT were related to the square root of time, indicating that a diffusion-controlled mechanism via the NCT-MAS complex particles and the film matrix controls NCT release. NCT release and permeation rates decreased with as the MAS ratio of the films was increased. However, the NCT-loaded CS-MAS films may have a potential adhesion to the mucosal membrane. These findings suggest that NCT-loaded CS-MAS films can be used as a buccal NCT delivery system.
authors.affiliation: Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand. thaned@kku.ac.th
authors.forename: Thaned
authors.initials: T
authors.lastname: Pongjanyakul
authors.forename: Wanwisa
authors.initials: W
authors.lastname: Khunawattanakul
authors.forename: Clare J
authors.initials: CJ
authors.lastname: Strachan
authors.forename: Keith C
authors.initials: KC
authors.lastname: Gordon
authors.forename: Satit
authors.initials: S
authors.lastname: Puttipipatkhachorn
authors.forename: Thomas
authors.initials: T
authors.lastname: Rades
mesh_terms: D017607:Aluminum Compounds; D000538:Aluminum Silicates / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D008274:Magnesium / Q000737:chemistry*; D017616:Magnesium Compounds; D009061:Mouth Mucosa / Q000378:metabolism*; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D009538:Nicotine / Q000008:administration & dosage* / Q000737:chemistry; D017640:Silicates; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D017607:Aluminum Compounds; D000538:Aluminum Silicates; D004337:Drug Carriers; D017616:Magnesium Compounds; D017640:Silicates; D009538:Nicotine; C033065:aluminum magnesium silicate; D048271:Chitosan; D008274:Magnesium