title: Shades of gray between large B-cell lymphomas and Hodgkin lymphomas: differential diagnosis and biological implications.
abstract: Hodgkin lymphomas (HLs) are neoplasms of large B cells. Two types are recognized: nodular lymphocyte predominant HL (NLPHL) and classical HL (CHL). In both types, there may be morphological and possibly biological overlap with large B-cell lymphomas (LBCLs) of non-HL types. These include nodular sclerosis CHL and primary mediastinal large B-cell lymphoma; CHL rich in lymphocytes and NLPHL; and NLPHL and T-cell/histiocyte-rich LBCL. This review covers the defining features of each of these diseases, the borderlines between them, and strategies for differential diagnosis.
authors.affiliation: Department of Pathology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street, Boston, MA 02114, USA. nlharris@partners.org
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Harris
mesh_terms: D003937:Diagnosis, Differential; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*