title: The adipose tissue production of adiponectin is increased in end-stage renal disease.
abstract: Adiponectin has antidiabetic properties, and patients with obesity, diabetes, and insulin resistance have low plasma adiponectin levels. However, although kidney disease is associated with insulin resistance, adiponectin is elevated in end-stage renal disease. Here we determine whether adipose tissue production of adiponectin is increased in renal disease in a case-control study of 36 patients with end-stage renal disease and 23 kidney donors. Blood and tissue samples were obtained at kidney transplantation and donation. The mean plasma adiponectin level was significantly increased to 15.6 mg/ml in cases compared with 8.4 mg/ml in controls. Plasma levels of the inflammatory adipokines tumor necrosis factor α, interleukin 6, and high-sensitivity C-reactive protein were significantly higher in cases compared with controls. Adiponectin mRNA and protein expression in visceral and subcutaneous fat were significantly higher in cases than controls, while adiponectin receptor-1 mRNA expression was significantly increased in peripheral blood cells, muscle, and adipose tissue in cases compared with controls. Thus, our study suggests that adipose tissue production of adiponectin contributes to the high plasma levels seen in end-stage renal disease.
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. maria.p.martinez@jefferson.edu
authors.forename: Maria P
authors.initials: MP
authors.lastname: Martinez Cantarin
authors.forename: Scott A
authors.initials: SA
authors.lastname: Waldman
authors.forename: Cataldo
authors.initials: C
authors.lastname: Doria
authors.forename: Adam M
authors.initials: AM
authors.lastname: Frank
authors.forename: Warren R
authors.initials: WR
authors.lastname: Maley
authors.forename: Carlo B
authors.initials: CB
authors.lastname: Ramirez
authors.forename: Scott W
authors.initials: SW
authors.lastname: Keith
authors.forename: Bonita
authors.initials: B
authors.lastname: Falkner
mesh_terms: D052242:Adiponectin / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis; D054419:Receptors, Adiponectin / Q000032:analysis
chemical_list: C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; D052242:Adiponectin; D012333:RNA, Messenger; D054419:Receptors, Adiponectin