title: Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion.
abstract: Tumours evolve several mechanisms to evade apoptosis, yet many resected carcinomas show significantly elevated caspase activity. Moreover, caspase activity is positively correlated with tumour aggression and adverse patient outcome. These observations indicate that caspases might have a functional role in promoting tumour invasion and metastasis. Using a Drosophila model of invasion, we show that precise effector caspase activity drives cell invasion without initiating apoptosis. Affected cells express the matrix metalloprotinase Mmp1 and invade by activating Jnk. Our results link Jnk and effector caspase signalling during the invasive process and suggest that tumours under apoptotic stresses from treatment, immune surveillance or intrinsic signals might be induced further along the metastatic cascade.
authors.affiliation: Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA.
authors.forename: Vivek A
authors.initials: VA
authors.lastname: Rudrapatna
authors.forename: Erdem
authors.initials: E
authors.lastname: Bangi
authors.forename: Ross L
authors.initials: RL
authors.lastname: Cagan
mesh_terms: D000818:Animals; D017209:Apoptosis; D053148:Caspase 3 / Q000378:metabolism*; D002465:Cell Movement; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster; D004789:Enzyme Activation; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology; D009479:Neuropeptides / Q000378:metabolism; D015398:Signal Transduction; D014921:Wings, Animal / Q000473:pathology*
chemical_list: D029721:Drosophila Proteins; C108880:HID protein, Drosophila; D009479:Neuropeptides; D048031:JNK Mitogen-Activated Protein Kinases; D053148:Caspase 3; D020781:Matrix Metalloproteinase 1