title: Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis.
abstract: Hunanamycin A, the first natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin A is related to a degradation product of riboflavin but has undergone an N-prenylation and subsequent cyclization. The structure, including stereochemistry, was determined by NMR and MS methods. Hunanamycin A exhibits a minimum inhibitory concentration (MIC) of 12.4 μM against the bacterial pathogen Salmonella enterica.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.
authors.forename: Youcai
authors.initials: Y
authors.lastname: Hu
authors.forename: Kezhan
authors.initials: K
authors.lastname: Wang
authors.forename: John B
authors.initials: JB
authors.lastname: MacMillan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001407:Bacillus / Q000737:chemistry*; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011810:Quinoxalines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019779:Salmonella enterica / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011810:Quinoxalines; C581025:hunanamycin A