title: Axonal regulation of Schwann cell ensheathment and myelination.
abstract: Axons in the vertebrate peripheral nervous system are intimately associated with Schwann cells. Axons regulate the Schwann cell phenotype, determining whether they myelinate individual axons or ensheathe multiple, small axons in Remak bundles. Our current understanding of the axonal signals that drive Schwann cells towards these distinct morphological and phenotypic fates is briefly reviewed here. Elucidation of these signals, and the intracellular pathways they regulate, may lead to new, rational therapies for the treatment of inherited and acquired neuropathies.
authors.affiliation: Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. james.salzer@nyumc.org
authors.forename: James L
authors.initials: JL
authors.lastname: Salzer
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D006801:Humans; D009186:Myelin Sheath / Q000502:physiology*; D012583:Schwann Cells / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology