title: Laryngeal ulceration and hemoptysis secondary to inadvertent alendronate overdose: case report and review of the literature.
abstract: Alendronate is commonly used in the treatment of osteoporosis and other bone diseases. Its drug profile includes many recognized side effects, and the literature includes case reports of esophageal irritation and ulceration. However, little has been published about laryngeal effects. We describe the case of a 77-year-old man who presented with hemoptysis secondary to laryngeal ulceration caused by the inadvertent misuse of alendronate. This case highlights the need for otolaryngologists to be familiar with alendronate and its side effects.
authors.affiliation: Department of Otolaryngology, St. Peter's University Hospital, New Brunswick, NJ, USA.
authors.forename: John
authors.initials: J
authors.lastname: Hanna
authors.forename: Joseph
authors.initials: J
authors.lastname: Bee
authors.forename: Robert T
authors.initials: RT
authors.lastname: Sataloff
mesh_terms: D000368:Aged; D019386:Alendronate / Q000506:poisoning*; D050071:Bone Density Conservation Agents / Q000506:poisoning*; D062787:Drug Overdose; D006469:Hemoptysis / Q000139:chemically induced*; D006801:Humans; D007818:Laryngeal Diseases / Q000139:chemically induced*; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy; D014456:Ulcer / Q000139:chemically induced*
chemical_list: D050071:Bone Density Conservation Agents; D019386:Alendronate