title: Fever and psychosis as an early presentation of Brucella-associated meningoencephalitis: a case report.
abstract: OBJECTIVE
  To describe a case with Brucella-associated meningoencephalitis. In addition, we report drug-induced hepatotoxicity due to acyclovir.
  
  
  METHODS
  A young woman was admitted with fever and psychosis and neuroimaging findings indicative of meningoencephalitis. Serology was positive for Brucella. She was treated with doxycycline, rifampin, and trimethoprim-sulfamethoxazole.
  
  
  CONCLUSIONS
  This case reminds physicians in endemic regions to consider neurobrucellosis as a differential diagnosis in patients with any unexplained neurologic symptoms or atypical psychosis. Early diagnosis and treatment of neurobrucellosis will be helpful in decreasing the sequelae of this complication.
authors.affiliation: Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Montazeri
authors.forename: Kourosh
authors.initials: K
authors.lastname: Sadeghi
authors.forename: Hosein
authors.initials: H
authors.lastname: Khalili
authors.forename: Setareh
authors.initials: S
authors.lastname: Davoudi
mesh_terms: D000212:Acyclovir / Q000009:adverse effects; D000328:Adult; D000900:Anti-Bacterial Agents; D001921:Brain; D002002:Brucella; D056486:Chemical and Drug Induced Liver Injury; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever / Q000209:etiology*; D006801:Humans; D008590:Meningoencephalitis / Q000150:complications* / Q000382:microbiology*; D009930:Organic Chemicals; D011618:Psychotic Disorders / Q000209:etiology*
chemical_list: D000900:Anti-Bacterial Agents; D009930:Organic Chemicals; C112033:antiviral 1592; D000212:Acyclovir