title: The receptor-binding site of the measles virus hemagglutinin protein itself constitutes a conserved neutralizing epitope.
abstract: Here, we provide direct evidence that the receptor-binding site of measles virus (MV) hemagglutinin protein itself forms an effective conserved neutralizing epitope (CNE). Several receptor-interacting residues constitute the CNE. Thus, viral escape from neutralization has to be associated with loss of receptor-binding activity. Since interactions with both the signaling lymphocyte activation molecule (SLAM) and nectin4 are critical for MV pathogenesis, its escape, which results from loss of receptor-binding activity, should not occur in nature.
authors.affiliation: Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan. maino@nih.go.jp
authors.forename: Maino
authors.initials: M
authors.lastname: Tahara
authors.forename: Shinji
authors.initials: S
authors.lastname: Ohno
authors.forename: Kouji
authors.initials: K
authors.lastname: Sakai
authors.forename: Yuri
authors.initials: Y
authors.lastname: Ito
authors.forename: Hideo
authors.initials: H
authors.lastname: Fukuhara
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Komase
authors.forename: Melinda A
authors.initials: MA
authors.lastname: Brindley
authors.forename: Paul A
authors.initials: PA
authors.lastname: Rota
authors.forename: Richard K
authors.initials: RK
authors.lastname: Plemper
authors.forename: Katsumi
authors.initials: K
authors.lastname: Maenaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Takeda
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D018985:Epitopes, B-Lymphocyte / Q000276:immunology*; D006389:Hemagglutinins, Viral / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D018985:Epitopes, B-Lymphocyte; D006389:Hemagglutinins, Viral; C032397:hemagglutinin protein G, measles virus