title: Cyanide antidotes for mass casualties: water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration.
abstract: Current cyanide antidotes are administered by IV infusion, which is suboptimal for mass casualties. Therefore, in a cyanide disaster, intramuscular (IM) injectable antidotes would be more appropriate. We report the discovery of the highly water-soluble sulfanegen triethanolamine as a promising lead for development as an IM injectable cyanide antidote.
authors.affiliation: Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, USA. patte219@umn.edu
authors.forename: Steven E
authors.initials: SE
authors.lastname: Patterson
authors.forename: Alexandre R
authors.initials: AR
authors.lastname: Monteil
authors.forename: Jonathan F
authors.initials: JF
authors.lastname: Cohen
authors.forename: Daune L
authors.initials: DL
authors.lastname: Crankshaw
authors.forename: Robert
authors.initials: R
authors.lastname: Vince
authors.forename: Herbert T
authors.initials: HT
authors.lastname: Nagasawa
mesh_terms: D000931:Antidotes / Q000627:therapeutic use*; D003486:Cyanides / Q000506:poisoning*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D007273:Injections, Intramuscular; D054527:Mass Casualty Incidents; D011041:Poisoning / Q000188:drug therapy; D011807:Quinolizines / Q000627:therapeutic use*; D012492:Salts; D013457:Sulfur Compounds / Q000627:therapeutic use*
chemical_list: D000931:Antidotes; D003486:Cyanides; D011807:Quinolizines; D012492:Salts; D013457:Sulfur Compounds; C438055:dithiane; C008366:3-mercaptopyruvic acid; D003545:Cysteine