title: UV filters, ingredients with a recognized anti-inflammatory effect.
abstract: BACKGROUND
  To explain observed differences during SPF determination using either an in vivo or in vitro method, we hypothesized on the presence of ingredients having anti-inflammatory properties.
  
  
  RESULTS
  To research our hypothesis, we studied the 21 UV filters both available on the market and authorized by European regulations and subjected these filters to the phorbol-myristate-acetate test using mice. We then catalogued the 13 filters demonstrating a significant anti-inflammatory effect with edema inhibition percentages of more than 70%. The filters are: diethylhexyl butamido triazone (92%), benzophenone-5 and titanium dioxide (90%), benzophenone-3 (83%), octocrylène and isoamyl p-methoxycinnamate (82%), PEG-25 PABA and homosalate (80%), octyl triazone and phenylbenzimidazole sulfonic acid (78%), octyl dimethyl PABA (75%), bis-ethylhexyloxyphenol methoxyphenyl triazine and diethylamino hydroxybenzoyl hexylbenzoate (70%). These filters were tested at various concentrations, including their maximum authorized dose. We detected a dose-response relationship.
  
  
  CONCLUSIONS
  The anti-inflammatory effect of a sunscreen ingredient may affect the in vivo SPF value.
authors.affiliation: Université de Nantes, Nantes Atlantique Universités, MMS, EA 2160, FR CNRS 3473, Nantes, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Couteau
authors.forename: Catherine
authors.initials: C
authors.lastname: Chauvet
authors.forename: Eva
authors.initials: E
authors.lastname: Paparis
authors.forename: Laurence
authors.initials: L
authors.lastname: Coiffard
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D051379:Mice; D013473:Sunscreening Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014466:Ultraviolet Rays
chemical_list: D000893:Anti-Inflammatory Agents; D013473:Sunscreening Agents