title: Mixed infection caused by Lecythophora canina sp. nov. and Plectosphaerella cucumerina in a German shepherd dog.
abstract: We describe an opportunistic, disseminated infection in a German shepherd dog associated with two fungal organisms not previously reported to cause disease. Lecythophora canina, a new species here described, was isolated from an osteolytic bone lesion. A fine needle aspirate of the lesion demonstrated septate hyphae. Plectospharella cucumerina (anamorph Plectosporium tabacinum) was isolated from a urine sample. Clinical manifestations were blindness, altered mentation, and osteomyelitis. Treatment with itraconazole and terbinafine for greater than one year resulted in stable clinical disease.
authors.affiliation: Department of Small Animal Clinical Sciences, Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, VA, USA. cvmgct@vt.edu
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Troy
authors.forename: David L
authors.initials: DL
authors.lastname: Panciera
authors.forename: J Phillip
authors.initials: JP
authors.lastname: Pickett
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.forename: Josepa
authors.initials: J
authors.lastname: Gene
authors.forename: José F
authors.initials: JF
authors.lastname: Cano
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Thompson
authors.forename: Brian L
authors.initials: BL
authors.lastname: Wickes
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D044963:Biopsy, Fine-Needle; D001842:Bone and Bones / Q000000981:diagnostic imaging; D060085:Coinfection / Q000382:microbiology / Q000662:veterinary*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D008853:Microscopy; D008969:Molecular Sequence Data; D009181:Mycoses / Q000382:microbiology / Q000662:veterinary*; D009894:Opportunistic Infections / Q000382:microbiology / Q000662:veterinary; D010019:Osteomyelitis / Q000382:microbiology / Q000662:veterinary; D011859:Radiography; D017422:Sequence Analysis, DNA; D014556:Urine / Q000382:microbiology
chemical_list: D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer