title: Effects of zafirlukast on capsular contracture: long-term results.
abstract: Capsular contracture is a distressing complication after breast augmentation for both the patient and surgeon. Although capsular contracture is a multifactorial process, one common denominator in the successful treatment of this complication is believed to be the abatement of inflammation. Leukotriene antagonists have recently emerged as effective prophylactic agents in reactive airway diseases. A prospective study was carried out on 60 female patients (120 prostheses implanted) with mild/severe capsular contracture in at least one breast. The hardness of capsular contracture was assessed by means of the mammary compliance method. Patients received zafirlukast (Accolate&#174;) for a 6-month period. Mammary compliance was assessed at the start of the study and thereafter monthly, during drug intake and for one year after drug withdrawal. The results show a significant decrease in breast compliance values in the first 6 months, followed by a significant increase one year after the end of drug intake. Indeed, zafirlukast-treated patients displayed a 6.93 percent reduction in mammary compliance after 1 month, 14.42 percent after 3 months, 22.05 percent after 6 months and 22.52 percent after 7 months (1 month after the withdrawal of the drug). Thereafter, mammary compliance values gradually increased. A 5.47 percent reduction in mammary compliance was observed 1 year after drug withdrawal. The present study suggests that zafirlukast may be effective in reducing breast capsule distortion in patients with long-standing contracture, though reduced capsular contracture values are strictly related to the duration of drug intake.
authors.affiliation: Department of Plastic Surgery, University of Perugia, Italy. mazzocc@mclink.it
authors.forename: M
authors.initials: M
authors.lastname: Mazzocchi
authors.forename: L A
authors.initials: LA
authors.lastname: Dessy
authors.forename: C
authors.initials: C
authors.lastname: Alfano
authors.forename: N
authors.initials: N
authors.lastname: Scuderi
mesh_terms: D000328:Adult; D003286:Contracture / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007211:Indoles; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D008264:Macrophages / Q000502:physiology; D016462:Mammaplasty / Q000009:adverse effects*; D008407:Mast Cells / Q000502:physiology; D008875:Middle Aged; D048448:Phenylcarbamates; D011446:Prospective Studies; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000627:therapeutic use*
chemical_list: D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D013449:Sulfonamides; D014105:Tosyl Compounds; C062735:zafirlukast