title: Exploiting pathogens' tricks of the trade for engineering of plant disease resistance: challenges and opportunities.
abstract: With expansion of our understanding of pathogen effector strategies and the multiplicity of their host targets, it is becoming evident that novel approaches to engineering broad-spectrum resistance need to be deployed. The increasing availability of high temporal gene expression data of a range of plant-microbe interactions enables the judicious choices of promoters to fine-tune timing and magnitude of expression under specified stress conditions. We can therefore contemplate engineering a range of transgenic lines designed to interfere with pathogen virulence strategies that target plant hormone signalling or deploy specific disease resistance genes. An advantage of such an approach is that hormonal signalling is generic so if this strategy is effective, it can be easily implemented in a range of crop species. Additionally, multiple re-wired lines can be crossed to develop more effective responses to pathogens.
authors.affiliation: College of Life and Environmental Sciences, University of Exeter, Exeter, Stocker Road, Exeter, EX4 4QD, UK. M.R.Grant@exeter.ac.uk
authors.forename: Murray R
authors.initials: MR
authors.lastname: Grant
authors.forename: Kemal
authors.initials: K
authors.lastname: Kazan
authors.forename: John M
authors.initials: JM
authors.lastname: Manners
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity*; D018556:Crops, Agricultural / Q000235:genetics*; D060467:Disease Resistance / Q000235:genetics*; D005818:Genetic Engineering / Q000379:methods*; D010935:Plant Diseases / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D010940:Plant Proteins / Q000235:genetics* / Q000378:metabolism; D030821:Plants, Genetically Modified / Q000235:genetics* / Q000382:microbiology
chemical_list: D010940:Plant Proteins