title: What are the antioxidant status predictors' factors among male chronic obstructive pulmonary disease (COPD) patients?
abstract: Imbalance between antioxidant and oxidative stress is a major risk factor for pathogenesis of some chronic diseases such as chronic obstructive pulmonary disease (COPD). This study aimed to determine antioxidant and oxidative stress status, and also theirs association with respiratory function of male COPD patients to find the antioxidant predictors' factors. A total of 149 subjects were involved in a cross-sectional study. The study was conducted at two medical centers in Kuala Lumpur, Malaysia. Results of the study showed that plasma vitamin C was low in most of the subjects (86.6%). Total antioxidant capacity was the lowest in COPD stage IV compare to other stages (p &lt; 0.05). Level of plasma vitamin A (p= 0.012) and vitamin C (p= 0.007) were low in malnourished subjects. The predictors for total antioxidant capacity were forced vital capacity (FVC) % predicted and intake of ?-carotene (R2= 0.104, p= 0.002). Number of cigarette (pack/ year) and smoking index (number/ year) were not associated with total antioxidant capacity of this COPD population. Plasma oxidative stress as assessed plasma lipid peroxidation (LPO) was only positively correlated with plasma glutathione (p= 0.002). It might be a need to evaluate antioxidant status especially in older COPD patients to treat antioxidant deficiency which is leading to prevent COPD progression.
authors.affiliation: Jundishapur University of Medical Sciences, Ahwaz, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Pirabbasi
authors.forename: Mahin
authors.initials: M
authors.lastname: Najafiyan
authors.forename: Maria
authors.initials: M
authors.lastname: Cheraghi
authors.forename: Suzana
authors.initials: S
authors.lastname: Shahar
authors.forename: Zahara
authors.initials: Z
authors.lastname: Abdul Manaf
authors.forename: Norfadilah
authors.initials: N
authors.lastname: Rajab
authors.forename: Roslina
authors.initials: R
authors.lastname: Abdul Manap
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis* / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood / Q000502:physiology; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005541:Forced Expiratory Volume; D006801:Humans; D008296:Malaysia; D008297:Male; D009752:Nutritional Status / Q000502:physiology*; D010045:Outpatients / Q000706:statistics & numerical data; D018384:Oxidative Stress / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000503:physiopathology; D014801:Vitamin A / Q000097:blood / Q000502:physiology; D014810:Vitamin E / Q000097:blood / Q000502:physiology; D014815:Vitamins / Q000097:blood* / Q000502:physiology
chemical_list: D000975:Antioxidants; D014815:Vitamins; D014801:Vitamin A; D014810:Vitamin E; D001205:Ascorbic Acid