title: Administration of tomato juice ameliorates lactate dehydrogenase and creatinine kinase responses to anaerobic training.
abstract: Creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) are important biological markers of various myocardial disorders and exercise-induced muscle damage. Lycopene, on the other side, is a natural anti-oxidant with protective action against cardiovascular risk. Fifteen anaerobically trained athletes with elevated LDH and CPK baseline levels were enrolled in this study after undergoing thorough biochemical and cardiovascular evaluation with echocardiocraphy. In nine athletes tomato juice, a lycopene plain juice, was administered during and after exercise, replacing the carbohydrate supplementation beverages commonly used during training for over a 2-month period. Tomato juice administration significantly reduced LDH and CPK levels, which returned back to almost normal levels. At the same time homocysteine and C-reactive protein were also attenuated. No changes were observed in the control group, where the usual carbohydrate supplementation had been followed.
authors.affiliation: General Chemical State Laboratory of Greece, 16 An. Tsocha Str., 11521 Athens, Greece. Electronic address: chtsitsi@yahoo.com.
authors.forename: Christina
authors.initials: C
authors.lastname: Tsitsimpikou
authors.forename: Nassia
authors.initials: N
authors.lastname: Kioukia-Fougia
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Tsarouhas
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Stamatopoulos
authors.forename: Elias
authors.initials: E
authors.lastname: Rentoukas
authors.forename: Aris
authors.initials: A
authors.lastname: Koudounakos
authors.forename: Peter
authors.initials: P
authors.lastname: Papalexis
authors.forename: Jyrki
authors.initials: J
authors.lastname: Liesivuori
authors.forename: Athanasios
authors.initials: A
authors.lastname: Jamurtas
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D001628:Beverages; D002097:C-Reactive Protein / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood*; D004452:Echocardiography; D015444:Exercise; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D018551:Solanum lycopersicum; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D055815:Young Adult
chemical_list: D000975:Antioxidants; D006710:Homocysteine; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase
keywords: Anaerobic training; Anti-oxidant; Creatinine phosphokinase; Lactate dehydrogenase; Lycopene