title: Association of gastroesophageal reflux disease risk with exacerbations of chronic obstructive pulmonary disease.
abstract: Gastroesophageal reflux disease (GERD) may be a potential risk factor for exacerbations of chronic obstructive pulmonary disease (COPD). The aim of the present study was to explore the association of GERD risk with exacerbations of COPD. Patients with COPD were consecutively recruited, and COPD Assessment Test (CAT) and Reflux Diagnostic Questionnaire (RDQ) were administered. If the CAT score was 5 points higher than that taken in the stable states, the patient was considered as having exacerbations of COPD. A RDQ score of ≥ 12 is defined high GERD risk. Univariate and multivariate logistic regression analyses were performed to evaluate the relationship between high GERD risk and exacerbations of COPD. Among 386 patients with COPD, the mean CAT score was 18.3 ± 6.6, and 76 (19.7%) patients had exacerbations during the 1-year follow-up. The mean RDQ score was 10.1 ± 4.7, and 132 (34.2%) patients were identified as having high GERD risk. Multivariate logistic regression analyses revealed that the high GERD risk (odds ratio, 2.31; 95% confidence interval, 1.29-3.87) was an independent risk factor of COPD exacerbations. In conclusion, high GERD risk appears to be associated with higher odds for COPD exacerbations.
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: B
authors.initials: B
authors.lastname: Liang
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Yi
authors.forename: Y
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000328:Adult; D000368:Aged; D000402:Airway Obstruction / Q000503:physiopathology; D015992:Body Mass Index; D001993:Bronchodilator Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000502:physiology; D005764:Gastroesophageal Reflux / Q000150:complications*; D006356:Heartburn / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012141:Respiratory Tract Infections / Q000150:complications; D012307:Risk Factors; D012907:Smoking; D013147:Spirometry; D014797:Vital Capacity / Q000502:physiology
chemical_list: D001993:Bronchodilator Agents
keywords: COPD; COPD assessment test; exacerbation; gastroesophageal reflux disease; reflux diagnostic questionnaire