title: Arundinols A-C and arundinones A and B from the plant endophytic fungus Microsphaeropsis arundinis.
abstract: Three new ent-eudesmane sesquiterpenoids, arundinols A-C (1-3), one isochroman-1-one, arundinone A (4), and a polyoxygenated benzofuran-3(2H)-one dimer, arundinone B (5), were isolated from the extract of a plant endophytic fungus, Microsphaeropsis arundinis. Their structures were elucidated primarily by NMR experiments, and 1 was confirmed by X-ray crystallography. The absolute configuration of 1 was assigned by X-ray crystallography using Cu Kα radiation, whereas those of the C-11 tertiary alcohols in 2 and 3 were deduced via the circular dichroism data of the in situ formed [Rh(2)(OCOCF(3))(4)] complexes. Arundinone B (5) represents the first dimeric benzofuran-3(2H)-one, showing cytotoxicity against T24 and A549 cells. The co-isolated known compound 6 showed a modest inhibitory effect against Staphylococcus aureus.
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Ji
authors.initials: J
authors.lastname: Luo
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Liu
authors.forename: Erwei
authors.initials: E
authors.lastname: Li
authors.forename: Liangdong
authors.initials: L
authors.lastname: Guo
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D001203:Ascomycota / Q000737:chemistry; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D008968:Molecular Conformation; D015394:Molecular Structure; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D045787:Sesquiterpenes, Eudesmane; C579183:arundinol A; C579185:arundinol B; C579187:arundinol C; C579184:arundinone A; C579186:arundinone B; C015872:eudesmane