title: Observations on the modified Wenker synthesis of aziridines and the development of a biphasic system.
abstract: A cheap and reliable process for the modified Wenker cyclization to afford aziridines has been achieved using biphasic conditions for a range of amino alcohol starting materials. A 100 mmol "one-pot" process has also been devised, and the enantiopurity of the starting amino alcohol is retained in the aziridine product.
authors.affiliation: Department of Chemistry, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK. b.r.buckley@lboro.ac.uk
authors.forename: Benjamin R
authors.initials: BR
authors.lastname: Buckley
authors.forename: Anish P
authors.initials: AP
authors.lastname: Patel
authors.forename: K G U
authors.initials: KG
authors.lastname: Wijayantha
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000605:Amino Alcohols; D001388:Aziridines