title: [Cardiopulmonary bypass models in rats: problems and perspectives].
abstract: Cardiopulmonary bypass (CBP) is the premise and guarantee for a successful cardiac surgery. However, its relatively high postoperative mortality and morbidity remains problematic. CPB models in rats have shown remarkable advantages over bigger animals, particularly when applied for research on postoperative cognitive dysfunction. Nevertheless, the high technical requirements limit its wide application. The establishment of an ideal CPB model in rats must mimic the clinical settings and should be highly repetitive.
authors.affiliation: Department of Anesthesiology, PUMC Hospital, CAMS and PUMC, Beijing, China. pumchzhubin@yahoo.com.cn
authors.forename: Bin
authors.initials: B
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass; D023421:Models, Animal; D051381:Rats