title: Wireless motility capsule test in children with upper gastrointestinal symptoms.
abstract: OBJECTIVE
  To compare scintigraphic gastric emptying and antroduodenal manometry (ADM) studies with the wireless motility capsule test in symptomatic pediatric patients.
  
  
  METHODS
  Patients aged 8-17 years with severe upper gastrointestinal symptoms (ie, nausea, vomiting, retching, abdominal pain) referred for ADM were recruited. A standardized protocol for ADM was used. On a different day, participants were given a standardized meal and then swallowed the wireless motility capsule. A wireless receiver unit worn during the study recorded transmitted data. If not performed previously, a 2-hour scintigraphic gastric emptying study was completed at the time of ADM testing.
  
  
  RESULTS
  A total of 22 patients were recruited, of whom 21 had complete scintigraphic gastric emptying study data and 20 had complete ADM data. The wireless motility capsule test had 100% sensitivity and 50% specificity in detecting gastroparesis compared with the 2-hour scintigraphic gastric emptying study. The wireless motility capsule test detected motor abnormalities in 17 patients, compared with 10 detected by ADM. Dichotomous comparison yielded a diagnostic difference between ADM and the wireless motility capsule test (P<.01). Migrating motor complexes were recognized in all patients by both ADM and the wireless motility capsule test. The wireless motility capsule test was well tolerated in all patients, and there were no side effects.
  
  
  CONCLUSIONS
  In symptomatic pediatric patients, the wireless motility capsule test is highly sensitive compared with scintigraphic gastric emptying studies in detecting gastroparesis, and seems to be more sensitive than ADM in detecting motor abnormalities.
authors.affiliation: Department of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA. alex.green@ucsf.edu
authors.forename: Alex D
authors.initials: AD
authors.lastname: Green
authors.forename: Jaime
authors.initials: J
authors.lastname: Belkind-Gerson
authors.forename: Brian C
authors.initials: BC
authors.lastname: Surjanhata
authors.forename: Hayat
authors.initials: H
authors.lastname: Mousa
authors.forename: Braden
authors.initials: B
authors.lastname: Kuo
authors.forename: Carlo
authors.initials: C
authors.lastname: Di Lorenzo
mesh_terms: D000293:Adolescent; D053704:Capsule Endoscopy; D002648:Child; D005260:Female; D005746:Gastric Emptying; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D018589:Gastroparesis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity