title: Antihypertensive effects of bioactive tripeptides-a random effects meta-analysis.
abstract: A meta-analysis of possible antihypertensive effects of small doses of bioactive tripeptides isoleucine-proline-proline and valine-proline-proline in commercial milk products or tablets was carried out. A random effects model was used on 19 randomized, placebo-controlled clinical intervention trials (published 1996-October 2010) consisting of about 1500 prehypertensive or mildly hypertensive subjects.The overall blood pressure lowering for systolic blood pressure was -4.0 mmHg (95% CI -5.9 to -2.1 mmHg, P < 0.001) and for diastolic blood pressure -1.9 mmHg (95% CI -3.1 to -0.8 mmHg, P < 0.001). However, a positive effect was not reported in all the studies. The results suggest that rather small daily doses of the lactotripeptides in different functional food products may offer a valuable option as a non-pharmacological treatment of prehypertension or mild hypertension as part of life-style advice.
authors.affiliation: Valio Ltd, R&D, PO Box 30, 00039 Valio, Finland. anu.turpeinen@valio.fi
authors.forename: Anu M
authors.initials: AM
authors.lastname: Turpeinen
authors.forename: Salme
authors.initials: S
authors.lastname: Järvenpää
authors.forename: Hannu
authors.initials: H
authors.lastname: Kautiainen
authors.forename: Riitta
authors.initials: R
authors.lastname: Korpela
authors.forename: Heikki
authors.initials: H
authors.lastname: Vapaatalo
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D016001:Confidence Intervals; D019587:Dietary Supplements; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000188:drug therapy*; D008894:Milk Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D009842:Oligopeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000959:Antihypertensive Agents; D008894:Milk Proteins; D009842:Oligopeptides; C489032:isoleucyl-prolyl-proline; C489031:valyl-prolyl-proline