title: Expression of rhesus blood group antigens in HTLV-i infection in northeast Iran.
abstract: BACKGROUND
  Human T-cell lymphoma/leukemia virus type 1 (HTLV-1) infection is relatively common in northeast Iran. It is important to understand which factors play a role in the pathogenesis of this virus. Blood group antigens may act as a receptor for various infectious agents. This study was performed to detect any association between Rh blood group antigens and HTLV-1 infection in northeast Iran.
  
  
  METHODS
  In this case and control study, Rhesus blood group antigens (D, C, c, E and e) were determined within 24 hours of blood collection by commercial antibodies in 100 HTLV-I infected individuals and 332 healthy blood donors at the Khorasan Blood Transfusion Center, Mashhad, Iran, in 2011. The results of HTLV-I positive subjects and the control group were compared using SPSS software.
  
  
  RESULTS
  The frequencies of Rh blood group antigens in the case group were D in 88%, C in 72%, c in 68%, E in 27%, and e in 94%. In the control group the frequencies were D in 91%, C in 75.5%, c in 72.9%, E in 28.6% and e in 98.2%. Chi-square test showed a significant difference between the two groups for the frequency of e antigen (p = 0.03).
  
  
  CONCLUSIONS
  Our study showed that e antigen expression is associated with a decreased risk of HTLV-I infection in northeast Iran.
authors.affiliation: Cancer Molecular Pathology Research Center, Department of Hematology and Blood Bank, Faculty of Medicine, Mashhad University of Medical Sciences (MUMS), Iran.
authors.forename: Mohammad Hadi
authors.initials: MH
authors.lastname: Sadeghian
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Keramati
authors.forename: Hossein
authors.initials: H
authors.lastname: Ayatollahi
authors.forename: Atefeh
authors.initials: A
authors.lastname: Shirinzadeh-Feizabadi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Sobhani
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Tehranaian
authors.forename: Hossein
authors.initials: H
authors.lastname: Shakibaie
mesh_terms: D000293:Adolescent; D000328:Adult; D001324:Autoantigens / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015490:HTLV-I Infections / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D055815:Young Adult
chemical_list: D001324:Autoantigens; D012204:Rh-Hr Blood-Group System