title: [Study of blood flow improvement of topical application of estrogen on low genitourinary tract and its safety].
abstract: OBJECTIVE
  The study of blood flow improvement of local estrogen on the low genitourinary tract and its safety.
  
  
  METHODS
  The color Doppler flow imaging technique was employed to observe the flow spectrum of genitourinary tract. During the period of February 2007 to December 2010, there were 78 cases of postmenopausal females on local estrogen. The Doppler parameters included vaginal wall, urethra resistance index (RI) and systolic/diastolic ratio and others. And the lower genital urinary tract symptoms, such as sexual satisfaction, vulvovaginitis, urinary frequency, nocturia and other improvements, as well as adverse drug reactions before treatment and after 1 month, 3 months were recorded and analyzed.
  
  
  RESULTS
  The results before treatment and after 1 month, 3 months, vaginal wall artery RI were 0.9 ± 0.2, 0.6 ± 0.2 and 0.7 ± 0.3; S/D 8.6 ± 3.7, 6.0 ± 2.9 and 6.4 ± 2.1; urethral artery RI 0.7 ± 0.2, 0.6 ± 0.2 and 0.6 ± 0.2, S/D 6.6 ± 1.9, 3.5 ± 0.7 and 3.4 ± 0.5 respectively. When the pre- and post-treatment indices were compared, the differences were statistically significant (P < 0.01). After using local estrogen in postmenopausal women, the resistance of lower genital urinary tract vasodilation decreased. Sexual satisfaction increased while the morbidities of vulvovaginitis, urinary frequency and nocturia decreased. The difference was statistically significant (P < 0.01).
  
  
  CONCLUSIONS
  Postmenopausal females on topical estrogen may promote the blood circulation of lower genitourinary tract, red.
authors.affiliation: Department of Obstetrics & Gynecology, Zhongnan Hospital, Wuhan University, China. huangfh1226@yahoo.com.cn
authors.forename: Feng-hua
authors.initials: FH
authors.lastname: Huang
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Zhang
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Xiao
authors.forename: Yi-yong
authors.initials: YY
authors.lastname: Xu
authors.forename: Yuan-zhen
authors.initials: YZ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D018615:Ultrasonography, Doppler, Color; D014521:Urethra / Q000098:blood supply* / Q000000981:diagnostic imaging; D001743:Urinary Bladder / Q000098:blood supply / Q000000981:diagnostic imaging; D014621:Vagina / Q000098:blood supply* / Q000000981:diagnostic imaging
chemical_list: D004967:Estrogens