title: Oral sildenafil as a rescue therapy in presumed acute pulmonary hypertensive crisis.
abstract: A 23-week-old baby, born at 26(+2) weeks, presented to the hospital with critical respiratory failure, which was impossible to stabilize. She had unstable oxygen saturations between 35% and 95%. A presumptive diagnosis of bronchopulmonary dysplasia with associated pulmonary hypertensive crisis was made. In the absence of inhaled nitric oxide, 2 oral doses of 1 mg/kg sildenafil were given, with a dramatic improvement 30 to 45 minutes later. Her oxygenation index fell from 43 to 14. She made a full recovery and was discharged from the hospital 2 weeks later.
authors.affiliation: BMBS, Paediatric Intensive Care Unit, Nottingham Children's Hospital, Queen's Medical Centre, Derby Rd, Nottingham, NG7 2UH United Kingdom. andrewmaxted@nhs.net
authors.forename: Andrew Peter
authors.initials: AP
authors.lastname: Maxted
authors.forename: Abigail
authors.initials: A
authors.lastname: Hill
authors.forename: Patrick
authors.initials: P
authors.lastname: Davies
mesh_terms: D000284:Administration, Oral; D001997:Bronchopulmonary Dysplasia / Q000097:blood / Q000150:complications / Q000175:diagnosis; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006323:Heart Arrest / Q000097:blood / Q000209:etiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D007363:Intensive Care Units, Neonatal; D007441:Intubation, Gastrointestinal; D010100:Oxygen / Q000097:blood; D058986:Phosphodiesterase 5 Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D010879:Piperazines / Q000008:administration & dosage* / Q000009:adverse effects; D011687:Purines / Q000008:administration & dosage / Q000009:adverse effects; D012131:Respiratory Insufficiency / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000008:administration & dosage* / Q000009:adverse effects; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D010100:Oxygen