title: Risk factors for development of methicillin-resistant Staphylococcus aureus infection among colonized patients.
abstract: BACKGROUND
  This study was conducted to identify clinical factors associated with development of infection caused by methicillin-resistant Staphylococcus aureus (MRSA) among hospitalized patients with nasal MRSA colonization.
  
  
  METHODS
  We conducted a prospective cohort with nested case-control study at a 672-bed, public, academic hospital in Dallas, Texas. The study duration was from January 1, 2008, to July 28, 2009. From the cohort of patients who had presence of nasal colonization with MRSA at admission, we identified patients who developed subsequent infection with MRSA during a 3-month period. We compared these patients (cases) with colonized patients who remained uninfected (controls; 2 controls per case). We collected demographic and clinical data and performed statistical analyses.
  
  
  RESULTS
  During the 19-month study period, 426 patients were found to have nasal colonization with MRSA. Of these, 36 (8.5%) developed a subsequent infection with MRSA within 3 months. When these 36 cases were compared with 72 controls, the factors independently associated with the development of subsequent infection were development of pressure ulcer during hospital stay (adjusted odds ratio, 5.82; 95% confidence interval: 2.21-15.31; P value=.000) and preadmission steroid therapy (adjusted odds ratio, 13.2; 95% confidence interval: 2.44-70.97; P value=.003).
  
  
  CONCLUSIONS
  History of steroid therapy prior to admission and development of pressure ulcer are associated with increased risk of subsequent MRSA infection in patients nasally colonized with MRSA.
authors.affiliation: Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Ramarathnam
authors.forename: Brendan
authors.initials: B
authors.lastname: De Marco
authors.forename: Anthony
authors.initials: A
authors.lastname: Ortegon
authors.forename: Dale
authors.initials: D
authors.lastname: Kemp
authors.forename: James
authors.initials: J
authors.lastname: Luby
authors.forename: Pranavi
authors.initials: P
authors.lastname: Sreeramoju
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D017053:Infection Control / Q000706:statistics & numerical data*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008875:Middle Aged; D009296:Nasal Cavity / Q000382:microbiology*; D003668:Pressure Ulcer / Q000453:epidemiology / Q000382:microbiology*; D011446:Prospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013256:Steroids / Q000627:therapeutic use*; D013781:Texas / Q000453:epidemiology; D055815:Young Adult
chemical_list: D013256:Steroids