title: Severe hepatitis induced by cyproterone acetate: role of corticosteroids. A case report.
abstract: Cyproterone acetate (CPA) is an oral anti-androgen commonly used to treat advanced prostate cancer. A variety of hepatotoxic reactions has been reported with CPA. Here we describe a case of a male patient who developed severe drug-induced hepatotoxicity during the treatment with CPA. The case, presenting sub-acute hepatitis, was characterized by a rapid evolution of cirrhosis and a protracted activity during the period of a few months despite the treatment withdrawal and an apparent benefits of corticosteroids, suggesting their indication in life threatening cases.
authors.affiliation: Department of Health Sciences, University Magna Græcia of Catanzaro, Italy. labenavoli@unicz.it
authors.forename: Ludovico
authors.initials: L
authors.lastname: Abenavoli
authors.forename: Natasa
authors.initials: N
authors.lastname: Milic
authors.forename: Michel
authors.initials: M
authors.lastname: Beaugrand
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D019819:Budesonide / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D017373:Cyproterone Acetate / Q000009:adverse effects*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D002756:Cholagogues and Choleretics; D005938:Glucocorticoids; D017373:Cyproterone Acetate; D019819:Budesonide; D014580:Ursodeoxycholic Acid; D011241:Prednisone