title: Synthesis of new 1-aryl-6-benzylimidazo[1,2-a][1,3,5]triazines with potential pharmacological activity.
abstract: In the reaction of ethyl N-(1-arylimidazolidine-2-ylidene) carbamic acid ester with 4-chlorobenzylamine new derivatives of 1-(1-arylimidazolidine-2-ylidene)-3-arylurea (I-VI) were obtained. Cyclic derivatives of dihydroimidazo[l ,2-a][1,3,5]trizines were synthesized by condensation of 1-(1-arylimidazolidine-2-ylidene)-3-(4-chlorobenzyl)urea with carbonyldiimidazole (CDI) (VII-XII). The effect of compounds X, XI on the central nervous system of mice in some behavioral tests was investigated.
authors.affiliation: Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Unit, Lublin, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Rzadkowska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Szacoń
authors.forename: Dariusz
authors.initials: D
authors.lastname: Matosiuk
authors.forename: Ewa
authors.initials: E
authors.lastname: Kedzierska
authors.forename: Sylwia
authors.initials: S
authors.lastname: Fidecka
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000700:Analgesics; D007093:Imidazoles; D014227:Triazines