title: New approaches under development: cardiovascular embryology applied to heart disease.
abstract: Despite many innovative advances in cardiology over the past 50 years, heart disease remains a major killer. The steady progress that continues to be made in diagnostics and therapeutics is offset by the cardiovascular consequences of the growing epidemics of obesity and diabetes. Truly innovative approaches on the horizon have been greatly influenced by new insights in cardiovascular development. In particular, research in stem cell biology, the cardiomyocyte lineage, and the interactions of the myocardium and epicardium have opened the door to new approaches for healing the injured heart.
authors.affiliation: Division of Cardiology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
authors.forename: Karl
authors.initials: K
authors.lastname: Degenhardt
authors.forename: Manvendra K
authors.initials: MK
authors.lastname: Singh
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Epstein
mesh_terms: D000818:Animals; D048909:Diabetes Complications / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006331:Heart Diseases / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D010496:Pericardium / Q000196:embryology* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology