title: Comparison of central venous catheter and peripheral vein samples of antibiotics in children with cystic fibrosis.
abstract: PURPOSE.: To determine if accurate serum antibiotic levels can be obtained from central venous catheters (CVCs) in pediatric patients with cystic fibrosis. DESIGN AND METHODS.: Fifty paired CVC-peripheral vancomycin or tobramycin specimens were collected within 5 min of each other following a 5-ml flush and discard. Specimen samples were randomized by first site drawn. RESULTS.: CVC-peripheral antibiotic levels were highly correlated (r =.97, p <.001), with no statistically significant difference (t = 1.18, p =.25). Bland-Altman plot analysis revealed a bias of.47, with limits of agreement ranging from -4.20 to 6.87. PRACTICE IMPLICATIONS.: Accurate antibiotic concentrations can be obtained from CVCs, reducing pediatric patient trauma and stress.
authors.affiliation: Department of Pediatrics, Washington University. wilson_k@wustl.edu
authors.forename: Karen
authors.initials: K
authors.lastname: Wilson
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Jamerson
mesh_terms: D000293:Adolescent; D002405:Catheterization, Central Venous; D002406:Catheterization, Peripheral; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000188:drug therapy*; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D008297:Male; D012680:Sensitivity and Specificity; D013048:Specimen Handling; D014031:Tobramycin / Q000008:administration & dosage / Q000097:blood*; D014640:Vancomycin / Q000008:administration & dosage / Q000097:blood*
chemical_list: D014640:Vancomycin; D014031:Tobramycin