title: A novel fatty acid lipophilic index and risk of CHD in US men: the health professionals follow-up study.
abstract: Few epidemiological studies have examined the association between an overall fatty acid (FA) profile and CHD risk. The aim of the present study was to examine a novel index that summarises individual FA levels based on FA affinity and fluidity in relation to CHD risk in men. In a prospective nested case–control study, FA in plasma and erythrocytes were measured in 459 CHD cases and 879 matched controls. Lipophilic index (LI) was computed by summing the products between FA levels and melting point of each FA to reflect the overall FA lipophilicity. Among controls, higher plasma LI was significantly correlated with adverse profiles of blood lipids, inflammatory markers and adiponectin. After multivariate adjustment for age, smoking, BMI and other CHD risk factors, plasma LI was significantly associated with an increased risk of CHD: the relative risk was 1·61 (95% CI 1·03, 2·53; P for trend¼0·04) comparing extreme quintiles. This association was attenuated to 1·21 (95% CI 0·48, 3·09; P for trend¼0·77) after adjusting for plasma levels of total trans-FA, long-chain n-3 FA and polyunsaturated:saturated fat ratio. Erythrocyte LI was not significantly associated with CHD risk. The present data indicate that a novel LI is associated with an adverse profile of cardiovascular risk markers and increased risk of CHD in men; its usefulness as a complement of individual FA in assessing disease risk needs to be elucidated in future studies.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston MA 02115, USA.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wu
authors.forename: Eric L
authors.initials: EL
authors.lastname: Ding
authors.forename: Estefanía T
authors.initials: ET
authors.lastname: Toledo
authors.forename: Hannia
authors.initials: H
authors.lastname: Campos
authors.forename: Ana
authors.initials: A
authors.lastname: Baylin
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood* / Q000209:etiology; D004912:Erythrocytes / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood* / Q000737:chemistry; D015525:Fatty Acids, Omega-3 / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012307:Risk Factors; D044242:Trans Fatty Acids / Q000097:blood; D044366:Transition Temperature; D014481:United States
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D018836:Inflammation Mediators; D044242:Trans Fatty Acids