title: Molecular docking studies of (1E,3E,5E)-1,6-Bis(substituted phenyl)hexa-1,3,5-triene and 1,4-Bis(substituted trans-styryl)benzene analogs as novel tyrosinase inhibitors.
abstract: We simulated the docking of the tertiary structure of mushroom tyrosinase with our compounds. From the structure-tyrosinase inhibitory activity relationship, it is notable that compounds 4, 8 and 11 showed similar or better activity rates than kojic acid which was used as a positive control. Compounds 17, 21, and 23 among benzene analogs that possess the same substituent showed significantly lower tyrosinase inhibitory effects. Therefore, we have confirmed that among the compounds showing better tyrosinase inhibitory effects than kojic acid, the compounds with triene analogs have better tyrosinase inhibitory effect than the compounds with benzene analogs. Docking simulation suggested the mechanism of compounds by several key residues which had possible hydrogen bonding interactions. The pharmacophore model underlined the features of active compounds, 4,4'-((1E,3E,5E)-hexa-1,3,5-triene-1,6-diyl)diphenol, 5,5'-((1E,3E,5E)-hexa-1,3,5-triene-1,6-diyl)bis(2-methoxy-phenol), and 5,5'-((1E,3E,5E)-hexa-1,3,5-triene-1,6-diyl)dibenzene-1,3-diol among triene derivatives which had several hydrogen bond groups on both terminal rings. The soundness of the docking results and the agreement with the pharmacophores suggest that it can be conveniently exploited to design inhibitors with an improved affinity for tyrosinase.
authors.affiliation: Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Kumjeong-gu, Busan 609–735, Republic of Korea.
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Ha
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Daeui
authors.initials: D
authors.lastname: Park
authors.forename: Hyoung Oh
authors.initials: HO
authors.lastname: Jeong
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Park
authors.forename: Yun Jung
authors.initials: YJ
authors.lastname: Park
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Lee
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Lee
authors.forename: Hyung Ryong
authors.initials: HR
authors.lastname: Moon
authors.forename: Hae Young
authors.initials: HY
authors.lastname: Chung
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry; D062105:Molecular Docking Simulation; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D011090:Polyenes / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D001555:Benzene Derivatives; D004791:Enzyme Inhibitors; D011090:Polyenes; D011753:Pyrones; C011890:kojic acid; D014442:Monophenol Monooxygenase