title: Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis.
abstract: Eicosapentaenoic acid (EPA), one of the n-3 polyunsaturated fatty acids, is a neuroprotective lipid with anti-inflammatory properties. We investigated the possible therapeutic effect of EPA on experimental autoimmune encephalomyelitis (EAE). EAE mice were fed a diet with or without EPA. The clinical EAE scores of the EPA-fed mice were significantly lower than those of the non-EPA mice. In the EPA-treated mice, IFN-γ and IL-17 productions were remarkably inhibited and the expression levels of peroxisome proliferator-activated receptors were significantly enhanced in the CNS-infiltrating CD4T cells. Thus EPA shows promise as a potential new therapeutic agent against multiple sclerosis.
authors.affiliation: Department of Internal Medicine I, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka, 569-0801, Japan.
authors.forename: Kiichi
authors.initials: K
authors.lastname: Unoda
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Doi
authors.forename: Hideto
authors.initials: H
authors.lastname: Nakajima
authors.forename: Kazushi
authors.initials: K
authors.lastname: Yamane
authors.forename: Takafumi
authors.initials: T
authors.lastname: Hosokawa
authors.forename: Shimon
authors.initials: S
authors.lastname: Ishida
authors.forename: Fumiharu
authors.initials: F
authors.lastname: Kimura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hanafusa
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015704:CD4 Antigens / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D004195:Disease Models, Animal; D015118:Eicosapentaenoic Acid / Q000494:pharmacology* / Q000627:therapeutic use*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000178:diet therapy* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D007371:Interferon-gamma / Q000235:genetics / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D015851:Interleukin-7 / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D020556:Neutrophil Infiltration / Q000187:drug effects; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D018709:Statistics, Nonparametric; D058504:Th17 Cells / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
chemical_list: D015704:CD4 Antigens; D015851:Interleukin-7; D047492:Peroxisome Proliferator-Activated Receptors; D012333:RNA, Messenger; D016753:Interleukin-10; D007371:Interferon-gamma; D015118:Eicosapentaenoic Acid