title: Evaluation of an unshielded luminescence flow-through radio-HPLC detector for LC quality control and preparation of PET radiopharmaceuticals.
abstract: Radio-HPLC is an essential method to assess the purity of PET radiopharmaceuticals. The usual NaI scintillator radiodetector requires heavy, costly and cumbersome lead shielding. The luminescence LB 500 fLumo detector has been developed to tackle these drawbacks and achieve high sensitivity. The fLumo uses a photon counting detector combined with a flow-through cell modified with a solid melt-on scintillator only sensitive to the positron. This study demonstrates the usefulness of the fLumo for analysis and purification of PET radiopharmaceuticals.
authors.affiliation: Cyclotron Research Center, Liege University, Belgium.
authors.forename: David
authors.initials: D
authors.lastname: Thonon
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Kaisin
authors.forename: Jean
authors.initials: J
authors.lastname: Henrottin
authors.forename: Joël
authors.initials: J
authors.lastname: Aerts
authors.forename: Hans
authors.initials: H
authors.lastname: Van Malderen
authors.forename: André
authors.initials: A
authors.lastname: Luxen
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods; D005462:Fluorine Radioisotopes / Q000032:analysis*; D057230:Limit of Detection; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000032:analysis*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals