title: Discovery of novel 1,4-dihydropyridine-based PDE4 inhibitors.
abstract: Substituted 1,4-dihydropyridines were discovered as a novel and potent series of phosphodiesterase 4 (PDE4) inhibitors. Structure-activity relationships within this series have been carried out and studies revealed that the dihydropyridine core, with indole moiety and 3,4-dimethoxybenzyl group, is a potent analogue for PDE4 inhibition. These novel series of compounds were prepared via a 3-component reaction in a single pot. In vitro biological activity, modeling studies and crystallography data are also reported.
authors.affiliation: Department of Medicinal Chemistry, Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India. rajamohanreddyp@ilsresearch.org
authors.forename: Rajamohan R
authors.initials: RR
authors.lastname: Poondra
authors.forename: Ratnam V
authors.initials: RV
authors.lastname: Nallamelli
authors.forename: Chandana Lakshmi Teja
authors.initials: CL
authors.lastname: Meda
authors.forename: B N V
authors.initials: BN
authors.lastname: Srinivas
authors.forename: Anushka
authors.initials: A
authors.lastname: Grover
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Muttabathula
authors.forename: Sreedhara R
authors.initials: SR
authors.lastname: Voleti
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Sridhar
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
authors.forename: Kishore V L
authors.initials: KV
authors.lastname: Parsa
mesh_terms: D018360:Crystallography, X-Ray; D004095:Dihydropyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D055808:Drug Discovery; D058988:Phosphodiesterase 4 Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D004095:Dihydropyridines; D058988:Phosphodiesterase 4 Inhibitors; C038806:1,4-dihydropyridine