title: Association between the interleukin-6 gene -572 C/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis of 11,681 subjects.
abstract: The association between the interleukin-6 (IL-6) gene -572 C/G (rs1800796) polymorphism and type 2 diabetes mellitus (T2DM) risk remains controversial. Thus, we performed this meta-analysis by searching PubMed, Embase, Web of Science, CBMdisc and CNKI databases until January 30, 2012. In addition, hand searching of the references of identified articles was performed. A total of 10 case-control studies including 11,681 subjects were selected to evaluate the possible association. Our results showed evidence for significant association between the IL-6 gene -572 C/G polymorphism and T2DM risk (for G allele vs. C allele: odds ratio [OR] = 1.29, 95% confidence interval [CI] = 1.09-1.52, P = 0.002, P = 0.008 after Bonferroni testing; for G/G vs. C/C: OR = 1.89, 95% CI = 1.51-2.37, P < 0.00001, P < 0.00004 after Bonferroni testing; for GG vs. G/C + C/C: OR = 1.75, 95% CI = 1.20-2.56, P = 0.004, P = 0.016 after Bonferroni testing; for G/G + G/C vs. C/C: OR = 1.32, 95% CI = 1.11-1.57, P = 0.001, P = 0.004 after Bonferroni testing). In addition, similar results were obtained in the subgroup analysis based on ethnicity. In summary, the present meta-analysis suggests a significant association between the IL-6 gene -572 G allele and increased risk of T2DM.
authors.affiliation: Department of Emergency, Chinese PLA Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing, 100142, China. weiyyk@163.com
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Yin
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Sun
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Zhang
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Hu
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Liu
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Zeng
authors.forename: Rui-Jia
authors.initials: RJ
authors.lastname: Xu
authors.forename: Zhong-Dong
authors.initials: ZD
authors.lastname: Zhang
authors.forename: Zhi-Guo
authors.initials: ZG
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D015850:Interleukin-6