title: A graphene oxide-photosensitizer complex as an enzyme-activatable theranostic agent.
abstract: The development of a target-activatable "smart" platform with high-affinity and specificity is of great importance for a wide range of biomedical applications. Here, we attempted to develop a new enzyme-activatable graphene oxide-photosensitizer complex as a biologically tunable theranostic agent, making it promising for near-infrared (NIR) fluorescence imaging and photo-induced cancer therapy.
authors.affiliation: Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Korea.
authors.forename: Youngnam
authors.initials: Y
authors.lastname: Cho
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Kim
authors.forename: Yongdoo
authors.initials: Y
authors.lastname: Choi
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002735:Chlorophyllides; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D007259:Infrared Rays; D010087:Oxides / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000633:toxicity; D011166:Porphyrins / Q000737:chemistry; D026082:Singlet Oxygen / Q000378:metabolism
chemical_list: D002735:Chlorophyllides; D010087:Oxides; D017319:Photosensitizing Agents; D011166:Porphyrins; D026082:Singlet Oxygen; C062985:phytochlorin; D006108:Graphite; D006821:Hyaluronoglucosaminidase