title: In vivo molecular imaging of [125I]-labeled 3-iodothyronamine: a hibernation-inducing agent.
abstract: The present investigation was carried out with the objective of studying in vivo imaging of 3-iodothyronamine (T(1)AM) compound in mice. A simple and efficient synthesis of [(125)I]-T(1)AM was established, and a molecular imaging study was performed using micro-SPECT/CT at 1h post-injection of [(125)I]-T(1)AM. Imaging studies revealed the activity in the gastrointestinal tract and liver, indicating that [(125)I]-T(1)AM was distributed primarily in the liver, and excreted into the gastrointestinal tract through a bile duct.
authors.affiliation: Advanced Radiation Research Institute, Jeongeup, Jeonbuk, Republic of Korea.
authors.forename: Joo-Sang
authors.initials: JS
authors.lastname: Lee
authors.forename: Beom-Su
authors.initials: BS
authors.lastname: Jang
authors.forename: Chan-Moon
authors.initials: CM
authors.lastname: Chung
authors.forename: Inho
authors.initials: I
authors.lastname: Choi
authors.forename: Joong-Gon
authors.initials: JG
authors.lastname: Kim
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Park
mesh_terms: D000818:Animals; D005260:Female; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging / Q000378:metabolism; D007457:Iodine Radioisotopes / Q000737:chemistry; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D019275:Radiopharmaceuticals / Q000032:analysis* / Q000737:chemistry; D013047:Specific Pathogen-Free Organisms; D013970:Thyronines / Q000032:analysis* / Q000737:chemistry; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: C487948:3-iodothyronamine; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D013970:Thyronines