title: IL-8 but not other biomarkers of endothelial damage is associated with disease activity in patients with ankylosing spondylitis without treatment with anti-TNF agents.
abstract: The objective of the study was to investigate the association between IL-8 and other biomarkers of endothelial dysfunction (MCP-1, V-CAM, I-CAM) and the disease activity scores in a sample of 54 patients with ankylosing spondylitis (AS) without use of biological agents. Fifty-four AS patients without treatment with anti-TNFs agents between 18 and 80 years old, who met modified New York criteria and at the same time the axial ASAS criteria, were evaluated using an epidemiological questionnaire that included among others clinical data, BASDAI, BASFI, ASQoL, ASDAS and plasma levels of CRP, ESR, MCP-1, IL-8, ICAM-1 and VCAM-1. IL-8 varied in proportion to disease activity rates (BASDAI and ASDAS) p < 0.05, being strongly correlated with the disease activity. The levels of adhesion molecules I-CAM and VCAM, as described in other studies, were positively correlated with predisposing factors for cardiovascular disease. IL-8 has shown to be strongly correlated with clinical markers of disease activity and inflammatory activity and may be an additional variable to the overall assessment of the activity of the AS.
authors.affiliation: Federal University of Paraná, Curitiba, Paraná, Brazil. valderilio@hotmail.com
authors.forename: Valderilio Feijó
authors.initials: VF
authors.lastname: Azevedo
authors.forename: J R
authors.initials: JR
authors.lastname: Faria-Neto
authors.forename: Andrea
authors.initials: A
authors.lastname: Stinghen
authors.forename: Pedro G
authors.initials: PG
authors.lastname: Lorencetti
authors.forename: Wagner P
authors.initials: WP
authors.lastname: Miller
authors.forename: Beatriz P
authors.initials: BP
authors.lastname: Gonçalves
authors.forename: Carla C
authors.initials: CC
authors.lastname: Szyhta
authors.forename: Roberto
authors.initials: R
authors.lastname: Pecoits-Filho
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000276:immunology; D018932:Chemokine CCL2 / Q000097:blood; D004730:Endothelium, Vascular / Q000276:immunology*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011788:Quality of Life; D012307:Risk Factors; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000523:psychology; D011795:Surveys and Questionnaires; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; C508606:CXCL8 protein, human; D018932:Chemokine CCL2; C573420:ICAM1 protein, human; D016209:Interleukin-8; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1