title: Effect of Qingguangan on the expressions of MMP-2 and MMP-9 in filtering bleb after trabeculectomy in rabbits.
abstract: OBJECTIVE
  To explore the effect of Qingguangan on the expressions of MMP-2 and MMP-9 in filtering bleb scarring area after trabeculectomy in rabbit model.
  
  
  METHODS
  Thirty-two New Zealand rabbits were randomized into four groups: control group, experimental group, MMC group (ocular trabeculectomy in combination with MMC), and Qingguangan group. Trabeculectomy was performed on both eyes in each group except control group. Qingguangan group was mouth-fed with Qingguangan (solution). On postoperative day 14, the appearances of MMP-2 and MMP-9 on filtrating blebs were observed by immunohistochemistry.
  
  
  RESULTS
  Statistical differences of the expressions of MMP-2 and MMP-9 were noted among groups on day 14 following surgery. Histology immunohistochemistry showed significant differences on the expressions of MMP-2 and MMP-9 between each group (P<0.05).
  
  
  CONCLUSIONS
  Qingguangan can promote the expressions of MMP-2 and MMP-9.
authors.affiliation: Key Disciplines of Chinese Medicine Ophthalmology, the First Affiliated Hospital, Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Li
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Peng
authors.forename: Han-Yu
authors.initials: HY
authors.lastname: Tan
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
keywords: MMP-2; MMP-9; Qingguangan; trabeculectomy