title: [A patient with advanced gastroesophageal junction cancer responding completely to S-1 monotherapy].
abstract: A 74-year-old woman was referred to our hospital for a close examination. A gastrointestinal endoscopic examination revealed an advanced gastroesophageal junction cancer type 3, which was diagnosed as well-differentiated adenocarcinoma. Computed tomography(CT)showed liver and para-aortic lymph node metastases.She was treated with oral S-1 at 100mg/ day for 28 days, followed by a 14-day rest. After 3 courses of treatment, the primary tumor was greatly reduced. After 18 months of treatment, CT showed a complete response of the liver and also the para-aortic lymph node metastases. She is alive without severe adverse effects and recurrence 2.5 years after the start of S-1 administration.
authors.affiliation: Dept. of Surgery, Keiyu Hospital, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Shimada
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Aga
authors.forename: Ayako
authors.initials: A
authors.lastname: Shimada
authors.forename: Miki
authors.initials: M
authors.lastname: Hosaka
authors.forename: Shoji
authors.initials: S
authors.lastname: Shimada
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Onishi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamachika
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Seki
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Yasui
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Matsumoto
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001706:Biopsy; D004338:Drug Combinations; D004943:Esophagogastric Junction / Q000473:pathology*; D005260:Female; D006801:Humans; D010094:Oxonic Acid / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid