title: Telomere length and long-term endurance exercise: does exercise training affect biological age? A pilot study.
abstract: BACKGROUND
  Telomeres are potential markers of mitotic cellular age and are associated with physical ageing process. Long-term endurance training and higher aerobic exercise capacity (VO(2max)) are associated with improved survival, and dynamic effects of exercise are evident with ageing. However, the association of telomere length with exercise training and VO(2max) has so far been inconsistent. Our aim was to assess whether muscle telomere length is associated with endurance exercise training and VO(2max) in younger and older people.
  
  
  METHODS
  Twenty men; 10 young (22-27 years) and 10 old (66-77 years), were studied in this cross-sectional study. Five out of 10 young adults and 5 out of 10 older were endurance athletes, while other halves were exercising at a medium level of activity. Mean telomere length was measured as telomere/single copy gene-ratio (T/S-ratio) using quantitative real time polymerase chain reaction. VO(2max) was measured directly running on a treadmill.
  
  
  RESULTS
  Older endurance trained athletes had longer telomere length compared with older people with medium activity levels (T/S ratio 1.12±0.1 vs. 0.92±0.2, p = 0.04). Telomere length of young endurance trained athletes was not different than young non-athletes (1.47±0.2 vs. 1.33±0.1, p = 0.12). Overall, there was a positive association between T/S ratio and VO(2max) (r = 0.70, p = 0.001). Among endurance trained athletes, we found a strong correlation between VO(2max) and T/S ratio (r = 0.78, p = 0.02). However, corresponding association among non-athlete participants was relatively weak (r = 0.58, p = 0.09).
  
  
  CONCLUSIONS
  Our data suggest that VO(2max) is positively associated with telomere length, and we found that long-term endurance exercise training may provide a protective effect on muscle telomere length in older people.
authors.affiliation: K. G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Ida Beate Ø
authors.initials: IB
authors.lastname: Østhus
authors.forename: Antonella
authors.initials: A
authors.lastname: Sgura
authors.forename: Francesco
authors.initials: F
authors.lastname: Berardinelli
authors.forename: Ingvild Vatten
authors.initials: IV
authors.lastname: Alsnes
authors.forename: Eivind
authors.initials: E
authors.lastname: Brønstad
authors.forename: Tommy
authors.initials: T
authors.lastname: Rehn
authors.forename: Per Kristian
authors.initials: PK
authors.lastname: Støbakk
authors.forename: Håvard
authors.initials: H
authors.lastname: Hatle
authors.forename: Ulrik
authors.initials: U
authors.lastname: Wisløff
authors.forename: Javaid
authors.initials: J
authors.lastname: Nauman
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D010101:Oxygen Consumption; D010807:Physical Endurance; D010809:Physical Fitness; D010865:Pilot Projects; D012420:Running; D016615:Telomere / Q000235:genetics*; D059505:Telomere Homeostasis