title: Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature.
abstract: Human parvovirus B19 is a well-known cause of severe conditions in patients with sickle cell disease, but the molecular mechanisms of the infection are insufficiently understood. The different clinical outcome of the acute parvovirus B19 infection in two pediatric patients with sickle cell disease has been examined. One of them developed life-threatening condition requiring emergency transfusions, while the other had asymptomatic infection, diagnosed occasionally. Both cases had high viral load and identical subgenotype, indicating that the viral molecular characteristics play a minimal role in the infection outcome.
authors.affiliation: Hemotherapy Center of Ribeirão Preto, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil. svetlyosf@yahoo.com
authors.forename: Svetoslav Nanev
authors.initials: SN
authors.lastname: Slavov
authors.forename: Simone
authors.initials: S
authors.lastname: Kashima
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Silva-Pinto
authors.forename: Alberto Anastacio
authors.initials: AA
authors.lastname: Amarilla
authors.forename: Victor Hugo
authors.initials: VH
authors.lastname: Aquino
authors.forename: Dimas Tadeu
authors.initials: DT
authors.lastname: Covas
mesh_terms: D000208:Acute Disease; D000755:Anemia, Sickle Cell / Q000150:complications / Q000821:virology*; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications / Q000821:virology*; D016732:Parvovirus B19, Human / Q000235:genetics*; D010802:Phylogeny; D019562:Viral Load
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral