title: [Adult resident cardiomyocytes wake up: new axis for cardiac tissue regeneration].
abstract: All cardiomyopathies and more specifically myocardial infarction always evolve to cardiomyocytes death and the ensuing heart failure setting. So far, cardiac regenerative medicine has focused on the use of stem cells and completely ignored the resident cardiomyocytes, assumed in a postmitotic state. However, recent findings in zebrafish and mammalians challenge this view and suggest that these cells have some capacity to proliferate and can contribute to heart regeneration. In this review, we propose an overall synthesis about knowledge of the proliferative and regenerative capacities of resident cardiomyocytes, dealing with some mechanistic aspects. In the future, the accurate identification of molecular mechanisms allowing wake-up of resident cardiomyocyte proliferation will certainly open new therapeutic avenues in cardiac regeneration.
authors.affiliation: Institut des maladies métaboliques et cardiovasculaires (I2MC), Inserm UMR 1048, université Toulouse III Paul Sabatier, Bâtiment L3, 1, avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France. celine.mias@inserm.fr
authors.forename: Céline
authors.initials: C
authors.lastname: Mias
authors.forename: Gaël
authors.initials: G
authors.lastname: Genet
authors.forename: Atul
authors.initials: A
authors.lastname: Pathak
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Sénard
authors.forename: Céline
authors.initials: C
authors.lastname: Galés
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology*; D000663:Amphibians / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D065150:Cellular Reprogramming / Q000235:genetics / Q000502:physiology; D005399:Fishes / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D008322:Mammals / Q000502:physiology; D008954:Models, Biological; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000502:physiology*; D012038:Regeneration / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology