title: Probiotic metabolites as epigenetic targets in the prevention of colon cancer.
abstract: Dietary interventions for preventing colon cancer have recently attracted increased attention from researchers and clinicians. The probiotics have emerged as potential therapeutic agents but are also regarded as healthy dietary supplements for nutrition and health applications. The probiotic metabolome may interfere with various cellular and molecular processes, including the onset and progression of colon cancer. Probiotic metabolites may lead to the modulation of diverse cellular signal transduction and metabolic pathways. The gut microbial metabolites (organic acids, bacteriocins, peptides, etc.) have been noted to interact with multiple key targets in various metabolic pathways that regulate cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, and metastasis. Progress in this field suggests that epigenetic alterations will be widely used in the near future to manage colon cancer. The present review provides insights into the molecular basis of the therapeutic applications and the chemopreventive activities of certain probiotic metabolites, with emphasis on the interaction between these metabolites and the molecular signaling cascades that are considered to be epigenetic targets in preventing colon cancer.
authors.affiliation: Department of Microbiology and Immunology, National Institute of Nutrition, Hyderabad, India. manoj15micro@yahoo.co.in
authors.forename: Manoj
authors.initials: M
authors.lastname: Kumar
authors.forename: Ravinder
authors.initials: R
authors.lastname: Nagpal
authors.forename: Vinod
authors.initials: V
authors.lastname: Verma
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.forename: Navrinder
authors.initials: N
authors.lastname: Kaur
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Hemalatha
authors.forename: Sanjeev K
authors.initials: SK
authors.lastname: Gautam
authors.forename: Birbal
authors.initials: B
authors.lastname: Singh
mesh_terms: D018890:Chemoprevention; D003110:Colonic Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D019587:Dietary Supplements; D044127:Epigenesis, Genetic; D006801:Humans; D019936:Probiotics / Q000378:metabolism*; D015398:Signal Transduction