title: [Association of metabolic syndrome markers with abnormal alanine aminotransferase levels in healthy children].
abstract: BACKGROUND
  There is a high prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) among pediatric patients. The identification of clinical predictors of these conditions would allow a timely treatment.
  
  
  OBJECTIVE
  To evaluate the relationship between serum alanine aminotransferase levels and parameters of metabolic syndrome in asymptomatic school students without hepatic illness.
  
  
  METHODS
  A randomized sample of 175 children aged between 9 and 14 years (54% females) was selected, from a database of 3010 students living in Santiago, Chile. Weight, height, abdominal circumference, systolic and diastolic blood pressure were measured. A fasting blood sample was obtained to measure glucose, total cholesterol, HDL, LDL-cholesterol, triglycerides, alanine aminotransferase (ALT) and insulin levels.
  
  
  RESULTS
  Forty percent of participants were obese, 17% had metabolic syndrome and 13.1% had abnormal ALT levels. Compared with children with normal ALT levels, the latter had significantly higher waist obesity, body mass index, systolic and diastolic blood pressure and triglycerides. However on multivariate analysis, only waist obesity was independently associated with abnormal ALT levels (adjusted odds ratio 3.93, 95% confidence intervals 1.44-10.78, p = 0.008).
  
  
  CONCLUSIONS
  Only waist obesity was independently associated with abnormal ALT levels in this sample of children.
authors.affiliation: Unidad de Gastroenterología y Nutrición Pediátrica, Pontificia Universidad Católica de Chile, Chile. sarancib@med.puc.cl
authors.forename: Gabriel
authors.initials: G
authors.lastname: Arancibia
authors.forename: Hernán
authors.initials: H
authors.lastname: García
authors.forename: Francisca
authors.initials: F
authors.lastname: Jaime
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Bancalari
authors.forename: Paul R
authors.initials: PR
authors.lastname: Harris
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D002648:Child; D002677:Chile / Q000453:epidemiology; D005234:Fatty Liver / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D065626:Non-alcoholic Fatty Liver Disease; D056128:Obesity, Abdominal / Q000453:epidemiology; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D000410:Alanine Transaminase