title: The effect of individualized exercise interventions during treatment in pediatric patients with a malignant bone tumor.
abstract: BACKGROUND
  While research on exercise interventions during anticancer treatment is well-established in adults, only very few studies exist in children. However, pediatric patients experience great limitations to being physically active, and appropriate interventions are desired.
  
  
  METHODS
  The present study aimed at investigating the effects of individualized exercise interventions during inpatient stays on pediatric patients with a malignant bone tumor. The parameter of interest was physical activity (PA). Patients' PA during home stays was assessed 6 weeks as well as 3, 6, 12, and 18 months post-surgery. Patients were distinguished into an intervention group and a control group. All patients received endoprosthetic replacement of the affected bone in the same institution.
  
  
  RESULTS
  A constant increase in all PA parameters was observed during follow-up. Exercise interventions were possible and appeared worthwhile. The intervention group showed better PA results at all measurements; however, no significant differences between groups were found. Furthermore, differences decreased especially after the cessation of the intervention. General problems in reaching appropriate power and compliance were observed.
  
  
  CONCLUSIONS
  Individualized exercise interventions in pediatric bone tumor patients are possible and appear to be beneficial. Such interventions should be implemented in adjuvant care; however, future research is needed to understand more about the effects of different interventions.
authors.affiliation: Institute of Experimental Musculoskeletal Medicine (IEMM) Motion Analysis Lab, University Hospital Münster, Münster, Germany. winterco@uni-muenster.de
authors.forename: Corinna C
authors.initials: CC
authors.lastname: Winter
authors.forename: Carsten
authors.initials: C
authors.lastname: Müller
authors.forename: Jendrik
authors.initials: J
authors.lastname: Hardes
authors.forename: Georg
authors.initials: G
authors.lastname: Gosheger
authors.forename: Joachim
authors.initials: J
authors.lastname: Boos
authors.forename: Dieter
authors.initials: D
authors.lastname: Rosenbaum
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D002648:Child; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005684:Gait / Q000502:physiology*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D012516:Osteosarcoma / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D011184:Postoperative Period; D011446:Prospective Studies; D012512:Sarcoma, Ewing / Q000503:physiopathology / Q000601:surgery / Q000628:therapy; D016896:Treatment Outcome