title: Use of narrow-band imaging in detection of nasopharyngeal carcinoma.
abstract: OBJECTIVE
  To compare narrow-band images of nasopharyngeal carcinoma with those of normal adenoidal tissue.
  
  
  METHODS
  Patients with a nasopharyngeal mass were evaluated using both conventional white light and narrow-band light. Biopsies were performed and Epstein-Barr viral serology was tested for all patients.
  
  
  RESULTS
  Thirty consecutive patients were recruited. Twenty-one patients had normal adenoidal tissue and seven had nasopharyngeal carcinoma. One patient with papillary adenocarcinoma was excluded. The features of narrow-band imaging in normal adenoidal tissue were: (1) a regularly arranged follicular pattern, and (2) each 'follicle' comprising a pale centre with surrounding dark periphery. The features of narrow-band imaging in nasopharyngeal carcinoma were: (1) absence of surface patterns (n = 7), and/or (2) 'reverse', haphazard follicular pattern comprising a dark brown centre and pale periphery (n = 3).
  
  
  CONCLUSIONS
  Narrow-band imaging of the surface of adenoidal tissue and nasopharyngeal carcinoma appears to identify distinct, characteristic features as described. Narrow-band imaging may be a useful adjunct in differentiating normal adenoidal tissue from malignancy. Further studies are needed to evaluate its diagnostic accuracy.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Khoo Teck Puat Hospital, Singapore.
authors.forename: J F
authors.initials: JF
authors.lastname: Thong
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Khoo Teck Puat Hospital, Singapore.
authors.forename: D
authors.initials: D
authors.lastname: Loke
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Khoo Teck Puat Hospital, Singapore.
authors.forename: R
authors.initials: R
authors.lastname: Karumathil Sivasankarannair
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Khoo Teck Puat Hospital, Singapore.
authors.forename: P
authors.initials: P
authors.lastname: Mok
mesh_terms: D000234:Adenoids / Q000473:pathology*; D000328:Adult; D000368:Aged; D002277:Carcinoma; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging / Q000379:methods*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis*; D009305:Nasopharynx / Q000473:pathology*; D055815:Young Adult