title: Left ventricular remodelling after acute myocardial infarction: impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene.
abstract: BACKGROUND
  The development of left ventricular remodelling after acute myocardial infarction is a predictor of heart failure and mortality. The purpose of the present study was to assess whether the polymorphism of angiotensinogen (AGT) gene with threonine (T) instead of methionine (M) at amino acid 235 in exon 2 (M235T) had effects on cardiac remodelling after acute myocardial infarction.
  
  
  METHODS
  One hundred and forty-one patients (mean age 56.4±11.1 years) with a first acute myocardial infarction were enrolled. Within 24-72 hours of the onset of the symptoms and at a four month period two-dimensional echocardiography was performed. Remodelling was defined as a 20% increase from the baseline in left ventricular end-diastolic volume. The genotypes of the study group were compared with the reference group (n=1010) genotypes. AGT M235T polymorphism was determined using polymerase chain reaction amplification.
  
  
  RESULTS
  At follow-up, 49 patients (34.7%) were classified as having left ventricular remodelling. Anterior localization of the infarct (p=0.008), leucocyte count at admission (p=0.040), global left ventricular longitudinal strain (p=0.021) and MM genotype of AGT (p=0.024) were independent predictors of ventricular remodelling after myocardial infarction.
  
  
  CONCLUSIONS
  Anterior wall infarction, increased leucocyte count, decreased longitudinal strain of left ventricular and polymorphism of AGT M235T may predict remodelling after myocardial infarction.
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania diana.peksiene@gmail.com.
authors.forename: Diana
authors.initials: D
authors.lastname: Zaliaduonyte-Peksiene
authors.affiliation: Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Sandrita
authors.initials: S
authors.lastname: Simonyte
authors.affiliation: Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Vaiva
authors.initials: V
authors.lastname: Lesauskaite
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Vaskelyte
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Olivija
authors.initials: O
authors.lastname: Gustiene
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Vaida
authors.initials: V
authors.lastname: Mizariene
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Renaldas
authors.initials: R
authors.lastname: Jurkevicius
authors.affiliation: Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Giedre
authors.initials: G
authors.lastname: Jariene
authors.affiliation: Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Abdonas
authors.initials: A
authors.lastname: Tamosiunas
authors.affiliation: Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania.
authors.forename: Remigijus
authors.initials: R
authors.lastname: Zaliunas
mesh_terms: D000808:Angiotensinogen / Q000235:genetics*; D004452:Echocardiography; D005240:Feasibility Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D020257:Ventricular Remodeling / Q000235:genetics*
chemical_list: D000808:Angiotensinogen
keywords: Angiotensinogen; infarction; polymorphism; remodelling