title: Flat detector computed tomography angiography with intravenous contrast application: feasibility for visualization of cerebral arterial vasculature.
abstract: OBJECTIVE
  The aim of our study was to evaluate flat detector computed tomography angiography with peripheral intravenous contrast material application (FD-CTA) for visualization of cerebral arteries in comparison with intravenous multidetector computed tomography angiography (CTA) and intraarterial digital subtraction angiography (DSA).
  
  
  METHODS
  The study was approved by the local institutional review board and informed consent was obtained by all participants. Ten patients underwent FD-CTA, CTA, and DSA of the cerebral arterial vasculature for suspected cerebrovascular disease. The image data were evaluated by two readers in consensus for the visualization of cerebral arterial segments on a 5-point scale (0 = vessel cannot be distinguished; 4 = excellent image quality). The Wilcoxon signed-rank test was used for statistical analysis. Note that P < .05 was considered to indicate a significant difference.
  
  
  RESULTS
  The depiction of cerebral arterial segments with FD-CTA was significantly superior compared to CTA in most vessel segments (P < .05 in 20 of 23 anatomic regions) and was without significant difference compared with DSA in large and medium intracranial vessels.
  
  
  CONCLUSIONS
  The results suggest that the cerebral arteries can be visualized by FD-CTA in high resolution, in many vessel segments comparable to DSA.
authors.affiliation: Department of Neuroradiology, University Hospital of Erlangen, Erlangen, Germany. Marc.Saake@uk-erlangen.de
authors.forename: Marc
authors.initials: M
authors.lastname: Saake
authors.forename: Lorenz
authors.initials: L
authors.lastname: Breuer
authors.forename: Philipp
authors.initials: P
authors.lastname: Goelitz
authors.forename: Sabine
authors.initials: S
authors.lastname: Ott
authors.forename: Tobias
authors.initials: T
authors.lastname: Struffert
authors.forename: Arnd
authors.initials: A
authors.lastname: Doerfler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002533:Cerebral Angiography / Q000295:instrumentation* / Q000379:methods; D002539:Cerebral Arterial Diseases / Q000000981:diagnostic imaging*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000295:instrumentation* / Q000379:methods; D014963:X-Ray Intensifying Screens
chemical_list: D003287:Contrast Media
keywords: Angiography; cerebral; computed tomography; flat detector; intravenous