title: Comorbidities and short-term prognosis in patients hospitalized for acute exacerbation of COPD: the EPOC en Servicios de medicina interna (ESMI) study.
abstract: BACKGROUND
  Comorbidities are frequent in patients hospitalized for COPD exacerbation, but little is known about their relation with short-term mortality and hospital readmissions. Our hypothesis is that the frequency and type of comorbidities impair the prognosis within 12 weeks after discharge.
  
  
  METHODS
  A longitudinal, observational, multicenter study of patients hospitalized for a COPD exacerbation with spirometric confirmation was performed. Comorbidity information was collected using the Charlson index and a questionnaire that included other common conditions not included in this index. Dyspnea, functional status, and previous hospitalization for COPD or other reasons among other variables were investigated. Information on mortality and readmissions for COPD or other causes was collected up to 3 months after discharge.
  
  
  RESULTS
  We studied 606 patients, 594 men (89.9%), with a mean (SD) age of 72.6 (9.9) years and a postbronchodilator FEV1 of 43.2% (21.2). The mean Charlson index score was 3.1 (2.0). On admission, 63.4% of patients had arterial hypertension, 35.8% diabetes mellitus, 32.8% chronic heart failure, 20.8% ischemic heart disease, 19.3% anemia, and 34% dyslipemia. Twenty-seven patients (4.5%) died within 3 months. The Charlson index was an independent predictor of mortality (P &lt; .003; OR,1.23; 95% CI, 1.07-1.40), even after adjustment for age, FEV1, and functional status measured with the Katz index. Comorbidity was also related with the need for hospitalization from the ED, length of stay, and hospital readmissions for COPD or other causes.
  
  
  CONCLUSIONS
  Comorbidities are common in patients hospitalized for a COPD exacerbation, and they are related to short-term prognosis.
authors.affiliation: Internal Medicine Service, Hospital Universitario Mutua De Terrassa, Barcelona. Electronic address: 19908pam@comb.cat.
authors.forename: Pedro
authors.initials: P
authors.lastname: Almagro
authors.affiliation: Internal Medicine Service, Hospital General Universitario Gregorio Marañón, Madrid.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Cabrera
authors.affiliation: Internal Medicine Service, Hospital Royo Villanova, Zaragoza.
authors.forename: Jesus
authors.initials: J
authors.lastname: Diez
authors.affiliation: Internal Medicine Service, Hospital de Mataró, Barcelona.
authors.forename: Ramon
authors.initials: R
authors.lastname: Boixeda
authors.affiliation: Internal Medicine Service, Hospital Juan Negrín, Gran Canaria.
authors.forename: M Belen
authors.initials: MB
authors.lastname: Alonso Ortiz
authors.affiliation: Medical Departament, Laboratorios Chiesi, Barcelona.
authors.forename: Cristina
authors.initials: C
authors.lastname: Murio
authors.affiliation: Programa de Epidemiología e Investigación Clínica, Fundación Caubet-Centro Internacional de Medicina Respiratoria Avanzada (CIMERA), Baleares, Spain.
authors.forename: Joan B
authors.initials: JB
authors.lastname: Soriano
mesh_terms: D000368:Aged; D016009:Chi-Square Distribution; D015897:Comorbidity; D005260:Female; D006760:Hospitalization; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008137:Longitudinal Studies; D008297:Male; D010359:Patient Readmission / Q000706:statistics & numerical data; D011379:Prognosis; D016016:Proportional Hazards Models; D029424:Pulmonary Disease, Chronic Obstructive / Q000401:mortality / Q000503:physiopathology*; D012129:Respiratory Function Tests; D013030:Spain / Q000453:epidemiology; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires