title: Curcuminoids and resveratrol as anti-Alzheimer agents.
abstract: Alzheimer disease (AD) is by far the most common cause of dementia globally. This neurodegenerative disorder of the brain is chronic and progressive, characterized clinically by the deterioration in the key symptoms of behavioral and cognitive abilities. Treatment options for this disease currently are limited. Deposition of amyloid-β and tau hyperphosphorylation are cardinal pathologic features of AD that lead to the formation of neuronal plaques and neurofibrillary tangles, respectively. In addition to mounting research on herbal compounds for the treatment of AD, curcuminoids and resveratrol appear to be beneficial as anti-AD agents. Curcuminoids (curcumin and demethoxycurcumin) and resveratrol possess unique properties that make them especially worthy of further studies. This review article revisits and presents the current research done on the potential of the curcuminoids curcumin and demethoxycurcumin and the polyphenolic compound resveratrol as anti-AD compounds.
authors.affiliation: Department of Chemistry, Chung Yuan Christian University, Chung Li, Taiwan.
authors.forename: Oliver B
authors.initials: OB
authors.lastname: Villaflores
authors.forename: Ying-Ju
authors.initials: YJ
authors.lastname: Chen
authors.forename: Chih-Ping
authors.initials: CP
authors.lastname: Chen
authors.forename: Jui-Ming
authors.initials: JM
authors.lastname: Yeh
authors.forename: Tzong-Yuan
authors.initials: TY
authors.lastname: Wu
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D003474:Curcumin / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D036381:Diarylheptanoids; D006801:Humans; D008297:Male; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016564:Amyloid beta-Protein Precursor; D000975:Antioxidants; D036381:Diarylheptanoids; D013267:Stilbenes; D016875:tau Proteins; D003474:Curcumin; D000077185:Resveratrol; C050229:demethoxycurcumin