title: Stem cells and spinal cord injury repair.
abstract: Spinal cord injury (SCI) has remained a challenging area for scientists and clinicians due to the adverse and complex nature of its pathobiology. To date, clinical therapies for debilitating SCI are largely ineffective. However, emerging research evidence suggests that repair of SCI can be promoted by stem cell-based therapies in regenerative medicine. Over the past decade, therapeutic potential of different types of stem cells for the treatment of SCI have been investigated in preclinical models. These studies have revealed multiple beneficial roles by which stem cells can improve the outcomes of SCI. This chapter will summarize the recent advances in the application of stem cells in regenerative medicine for the repair of SCI.
authors.affiliation: Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada. karimis@cc.umanitoba.ca
authors.forename: Soheila
authors.initials: S
authors.lastname: Karimi-Abdolrezaee
authors.forename: Eftekhar
authors.initials: E
authors.lastname: Eftekharpour
mesh_terms: D000818:Animals; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology