title: MicroRNAs as potential clinical biomarkers: emerging approaches for their detection.
abstract: MicroRNAs (miRNAs) have emerged as novel post-transcriptional regulators of gene expression. These short non-coding RNAs are involved in diverse biological processes and their dysregulation is often observed under diseased conditions. Therefore, miRNAs hold great potential as clinical biomarkers of physiological and pathological states and extensive efforts are underway to develop efficient approaches for their detection. We review recent advances and discuss the promises and pitfalls of emerging methods of miRNA profiling and detection.
authors.affiliation: Mitchell Cancer Institute, University of South Alabama, Mobile.
authors.forename: S K
authors.initials: SK
authors.lastname: Srivastava
authors.forename: A
authors.initials: A
authors.lastname: Bhardwaj
authors.forename: S J
authors.initials: SJ
authors.lastname: Leavesley
authors.forename: W E
authors.initials: WE
authors.lastname: Grizzle
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: A P
authors.initials: AP
authors.lastname: Singh
mesh_terms: D015415:Biomarkers / Q000097:blood; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000097:blood / Q000235:genetics / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs