title: Bi-phasic effect of equol on adipocyte differentiation of MC3T3-L1 cells.
abstract: We investigated the effects of equol on adipogenesis by measuring lipid accumulation and analyzing the change in adipocyte-related gene expression in MC3T3-L1 cells. Treatment with 10 µM equol tended to increase adipocyte-related gene expression, whereas 100 µM equol reduced lipid accumulation and suppressed the expression of these genes and proteins. Our results suggest that equol regulated adipogenesis in a bi-phasic fashion.
authors.affiliation: Department of Food Function and Labeling, National Institute of Health and Nutrition, Tokyo, Japan.
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Nishide
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tousen
authors.forename: Masaki
authors.initials: M
authors.lastname: Inada
authors.forename: Chisato
authors.initials: C
authors.lastname: Miyaura
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ishimi
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D050156:Adipogenesis / Q000187:drug effects* / Q000235:genetics; D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics / Q000378:metabolism; D018955:CD36 Antigens / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D060754:Equol / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects*; D051379:Mice; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D048789:Phytoestrogens / Q000494:pharmacology*; D019014:fas Receptor / Q000235:genetics / Q000378:metabolism
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D018955:CD36 Antigens; C530718:CEBPA protein, mouse; C491899:Fas protein, mouse; D047495:PPAR gamma; D048789:Phytoestrogens; D019014:fas Receptor; D060754:Equol