title: Safety assessment of alkyl benzoates as used in cosmetics.
abstract: The functions of alkyl benzoates in cosmetics include fragrance ingredients, skin-conditioning agents--emollient, skin-conditioning agents--miscellaneous, preservatives, solvents, and plasticizers. The Cosmetic Ingredient Review Expert Panel reviewed the relevant animal and human data and noted gaps in the available safety data for some of the alkyl benzoates. Similar structure activity relationships, biologic functions, and cosmetic product usage allowed the available data of many of the alkyl benzoates to be extended to the entire group. Carcinogenicity data were not available, but available data indicated that these alkyl benzoate cosmetic ingredients are not genotoxic. Also benzoic acid and tested component alcohols were not reproductive or developmental toxicants, are not genotoxic in almost all assays, and are not carcinogenic. These ingredients were determined to be safe in the present practices of use and concentration.
authors.affiliation: Cosmetic Ingredient Review, Washington, DC 20036, USA.
authors.forename: Lillian C
authors.initials: LC
authors.lastname: 'Becker
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Hill
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Klaassen
authors.forename: Daniel
authors.initials: D
authors.lastname: Liebler
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Shank
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
authors.forename: Paul W
authors.initials: PW
authors.lastname: Snyder
authors.forename: F Alan
authors.initials: FA
authors.lastname: Andersen
mesh_terms: D000818:Animals; D001565:Benzoates / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D003257:Consumer Product Safety; D003358:Cosmetics / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D018570:Risk Assessment; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000378:metabolism / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D001565:Benzoates; D003358:Cosmetics; D013501:Surface-Active Agents