title: Introduction of a rabbit carotid artery model for sonothrombolysis research.
abstract: The goal of this study was to develop an in vivo sonothrombolysis model for stroke research. The rabbit carotid artery has average vessel diameters similar to human M1/M2 segments and allows generation of a thrombotic occlusion using various kinds of thrombus material as well as thrombus placement under visual control. It further allows real-time monitoring of flow and clot mechanics during the sonothrombolysis procedure using high-frequency diagnostic ultrasound. In the present study, the model will be introduced and first results to show feasibility using diagnostic as well as high-intensity focused ultrasound will be presented.
authors.affiliation: Brain Ultrasound Research Laboratory (BURL), Department of Radiology, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103-8756, USA.
authors.forename: Thilo
authors.initials: T
authors.lastname: Hölscher
authors.forename: David J
authors.initials: DJ
authors.lastname: Fisher
authors.forename: Golnaz
authors.initials: G
authors.lastname: Ahadi
authors.forename: Arne
authors.initials: A
authors.lastname: Voie