title: Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease.
abstract: OBJECTIVE
  The present study aimed to evaluate alterations in the levels of iron, divalent metal transporter 1 (DMT1) with the iron-responsive element (IRE), transferrin receptor 1 (TfR1), ferroportin 1 (FPN1), and iron regulatory protein 1 (IRP1) in the temporal cortex of human brains with Parkinson disease (PD).
  
  
  METHODS
  Iron content was measured using an ICP-MS 7500CE detector. IRP1, DMT1+IRE, TfR1, and FPN1 expressions were determined by Western blotting.
  
  
  RESULTS
  Iron content was significantly lower in the temporal cortex of patients with PD when compared with age-matched healthy controls. Unexpectedly, the levels of DMT1+IRE, TfR1, FPN1, and IRP1 were decreased in the temporal cortex in PD brains. No changes were observed in the temporal cortex of postmortem Alzheimer disease brains.
  
  
  CONCLUSIONS
  Iron deprivation and iron-related protein dysregulation suggest that a different iron regulatory mechanism may exist, and that iron redistribution may occur between the temporal cortex and the substantia nigra of patients with PD.
authors.affiliation: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines, Physiology, Medical College of Qingdao University, Qingdao, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Yu
authors.forename: Tingting
authors.initials: T
authors.lastname: Du
authors.forename: Ning
authors.initials: N
authors.lastname: Song
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.forename: Yong
authors.initials: Y
authors.lastname: Shen
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Junxia
authors.initials: J
authors.lastname: Xie
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D015703:Antigens, CD / Q000378:metabolism; D016022:Case-Control Studies; D027682:Cation Transport Proteins / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007501:Iron / Q000378:metabolism*; D035941:Iron Regulatory Protein 1 / Q000378:metabolism; D035925:Iron-Regulatory Proteins / Q000378:metabolism; D008297:Male; D010300:Parkinson Disease / Q000473:pathology*; D011180:Postmortem Changes; D011990:Receptors, Transferrin / Q000378:metabolism; D013054:Spectrophotometry, Atomic; D013702:Temporal Lobe / Q000378:metabolism*; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2
chemical_list: D015703:Antigens, CD; D027682:Cation Transport Proteins; D007501:Iron; D035941:Iron Regulatory Protein 1; D035925:Iron-Regulatory Proteins; D011990:Receptors, Transferrin; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2; C068126:CD71 antigen