title: [Analysis of fundus fluorescein angiography, indocyanine green angiography and choroidal thickness in central serous chorioretinopathy].
abstract: OBJECTIVE
  To evaluate the characteristics of choroidal thickness changes and abnormalities in choroidal circulation in cases of central serous chorioretinopathy (CSC).
  
  
  METHODS
  This was a case control study, we measured the bilateral choroidal thickness in 21 patients with unilateral CSC and 24 eyes of 24 age- and sex-matched normal subjects using enhanced depth imaging optical coherence tomography (EDI-OCT). The choroid was measured from the posterior edge of the retinal pigment epithelium (RPE) to the choroid-scleral junction at 500 µm intervals of a horizontal section from 3 mm temporal to the fovea to 3 mm nasal to the fovea. Paired-samples t-test was conducted to compare mean choroidal thicknesses between symptomatic eyes and fellow eyes of patients. The datum between patients and normal subjects were analyzed by independent-samples t-test. Fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were performed and the digital images were analyzed in CSC patients.
  
  
  RESULTS
  The 21 CSC patients had a mean age of 45.6 years, and 12 patients (57.1%) were male. The choroid in symptomatic eyes was thickest beneath the fovea (519.0 ± 102.5) µm. It was significantly thicker than that in the fellow eyes (439.3 ± 94.1) µm (t = 4.171, P < 0.05). Choroidal thickness in both groups was significantly greater than that in the eyes of age- and sex-matched normal subjects (332.0 ± 67.3) µm (t = 7.125, 4.441; P < 0.05). Choroidal thickness at each of the other 12 points showed a similar tendency (t = 2.544 to 3.819, 4.799 to 7.816, 2.487 to 5.236; P < 0.05). ICGA showed a choroidal filling delay (100%), vessels dilation (90.5%), and focal choroidal hyperfluorescence (100%) surrounding leakage from the RPE in symptomatic eyes. Pigment epithelium detachment with abnormal choroidal circulation was observed in 6 fellow eyes. In 4 symptomatic eyes and 11 fellow eyes, ICGA revealed choroidal hyperfluorescence but FFA showed normal appearance.
  
  
  CONCLUSIONS
  CSC seems to be a bilateral eye disease with choroidal focal ischemia followed by vessels congestion and hyperpermeability. EDI OCT is a useful tool for monitoring choroidal thickness changes caused by choroidal vascular hyperpermeability.
authors.affiliation: Department of Ophthalmology, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Lüe
authors.initials: L
authors.lastname: Li
authors.forename: Dong-hui
authors.initials: DH
authors.lastname: Li
authors.forename: Zhi-kun
authors.initials: ZK
authors.lastname: Yang
authors.forename: Ai-ling
authors.initials: AL
authors.lastname: Bian
authors.forename: You-xin
authors.initials: YX
authors.lastname: Chen
authors.forename: Fang-tian
authors.initials: FT
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D056833:Central Serous Chorioretinopathy / Q000000981:diagnostic imaging* / Q000473:pathology; D002829:Choroid / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D011859:Radiography; D041623:Tomography, Optical Coherence
chemical_list: D007208:Indocyanine Green