title: High-dose-rate interstitial brachytherapy for gynecologic malignancies--dosimetric changes during treatment period.
abstract: To overcome cranio-caudal needle displacement in pelvic high-dose-rate interstitial brachytherapy (HDRIB), we have been utilizing a fullystretched elastic tape to thrust the template into the perineum. The purpose of the current study was to evaluate dosimetric changes during the treatment period using this thrusting method, and to explore reproducible planning methods based on the results of the dosimetric changes. Twenty-nine patients with gynecologic malignancies were treated with HDRIB at the Cancer Institute Hospital. Pre-treatment and post-treatment computed tomography (CT) scans were acquired and a virtual plan for post-treatment CT was produced by applying the dwell positions/times of the original plan. For the post-treatment plan, D90 for the clinical target volume (CTV) and D2cc for the rectum and bladder were assessed and compared with that for the original plan. Cranio-caudal needle displacement relative to CTV during treatment period was only 0.7 ± 1.9 mm. The mean D90 values for the CTV in the pre- and post-treatment plans were stable (6.8 Gy vs. 6.8 Gy) and the post-treatment/pre-treatment D90 ratio was 1.00 ± 0.08. The post-/pre-treatment D2cc ratio was 1.14 ± 0.22 and the mean D2cc for the rectum increased for the post-treatment plan (5.4 Gy vs. 6.1 Gy), especially when parametrial infiltration was present. The mean D2cc for the bladder was stable (6.3 Gy vs. 6.6 Gy) and the ratio was 1.06 ± 0.20. Our thrusting method achieved a stable D90 for the CTV, in contrast to previous prostate HDRIB reports displaying reductions of 35-40% for D90 during the treatment period.
authors.affiliation: Department of Radiology, Tokyo University Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. tsuyopon13@gmail.com
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Onoe
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nose
authors.forename: Hideomi
authors.initials: H
authors.lastname: Yamashita
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshioka
authors.forename: Takashi
authors.initials: T
authors.lastname: Toshiyasu
authors.forename: Takuyo
authors.initials: T
authors.lastname: Kozuka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Oguchi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009339:Needles; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*; D014594:Uterine Neoplasms / Q000532:radiotherapy*; D014846:Vulvar Neoplasms / Q000532:radiotherapy*
keywords: dose–volume histogram; gynecologic malignancy; interstitial brachytherapy; needle displacement