title: Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989 and 2011.
abstract: From 1989 to 2011 in Kuala Lumpur, Malaysia, multiple genotypes from both respiratory syncytial virus (RSV) subgroups were found co-circulating each year. RSV-A subgroup predominated in 12 out of 17years with the remaining years predominated by RSV-B subgroup. Local RSV strains exhibited temporal clustering with RSV strains reported in previous epidemiological studies. Every few years, the existing predominant genotype was replaced by a new genotype. The RSV-A genotypes GA2, GA5 and GA7 were replaced by NA1 and NA2, while BA became the predominant RSV-B genotype. A unique local cluster, BA12, was seen in 2009, and the recently-described ON1 genotype with 72-nt duplication emerged in 2011. Our findings will have important implications for future vaccine intervention.
authors.affiliation: Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia. jics_lab@yahoo.com
authors.forename: Chee-Sieng
authors.initials: CS
authors.lastname: Khor
authors.forename: I-Ching
authors.initials: IC
authors.lastname: Sam
authors.forename: Poh-Sim
authors.initials: PS
authors.lastname: Hooi
authors.forename: Yoke-Fun
authors.initials: YF
authors.lastname: Chan
mesh_terms: D019143:Evolution, Molecular; D005838:Genotype; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008296:Malaysia / Q000453:epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000266:history; D018113:Respiratory Syncytial Virus, Human / Q000145:classification / Q000235:genetics*