title: Late spontaneous dissociation of a fluocinolone acetonide implant (Retisert).
abstract: OBJECTIVE
  To describe a case of spontaneous dissociation of a fluocinolone acetonide implant (Retisert) 5 years following implantation.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A patient with chronic uveitis underwent placement of a fluocinolone acetonide implant in the right eye in 2006. The patient's inflammation was well controlled and did not recur, so the device was not replaced.
  
  
  RESULTS
  Five years after implantation, the patient presented with a new complaint of a shadow in his vision. The drug pellet was found to have separated spontaneously from the anchoring strut and was floating in the vitreous. Pars plana vitrectomy was performed with removal of the drug pellet, and the anchoring strut was left in place.
  
  
  CONCLUSIONS
  Spontaneous intraocular dissociation of a fluocinolone acetonide implant (Retisert) can occur years after placement, in the absence of trauma or other risk factors. Surgeons and patients must be aware of this potential complication as the implants age.
authors: Soraya
authors: S
authors: Rofagha
authors: Tidarat
authors: T
authors: Prechanond
authors: Jay M
authors: JM
authors: Stewart
mesh_terms: D000293:Adolescent; D004343:Drug Implants / Q000009:adverse effects; D005446:Fluocinolone Acetonide / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005500:Follow-Up Studies; D005548:Foreign-Body Migration / Q000175:diagnosis* / Q000601:surgery; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D014605:Uveitis / Q000188:drug therapy* / Q000378:metabolism; D014821:Vitrectomy; D014822:Vitreous Body
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D005446:Fluocinolone Acetonide