title: Periodontal disease: a genetic perspective.
abstract: Periodontitis is a multifactorial disease that causes tooth loss. The complex pathogenesis of periodontitis implies the involvement of a susceptible host and a bacterial challenge. Many studies have provided a valuable contribution to understanding the genetic basis of periodontal disease, but the specific candidate genes of susceptibility are still unknown. In fact, genome-wide studies and screening of single-nucleotide polymorphisms have yielded new genetic information without a definitive solution for the management of periodontal disease. In this manuscript, we provide an overview of the most relevant literature, presenting the main concepts and insights of the strategies that have been emerging to better diagnose and treat periodontal disease based on biomarker analysis and host modulation.
authors: Department of Bucomaxillofacial Surgery and Traumatology and Periodontology, School of Dentistry at Ribeirão Preto, Univ of São Paulo, Ribeirão Preto, SP, Brazil. mtaba@usp.br
authors: Mario
authors: M
authors: Taba
authors: Sergio Luis Scombatti de
authors: SL
authors: Souza
authors: Viviane Casagrande
authors: VC
authors: Mariguela
mesh_terms: D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation; D006801:Humans; D009154:Mutation; D010510:Periodontal Diseases / Q000235:genetics* / Q000628:therapy; D011110:Polymorphism, Genetic; D012307:Risk Factors