title: Association between selected oral pathogens and gastric precancerous lesions.
abstract: We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was performed to measure periodontal indices. Plaque and saliva samples were tested with real-time quantitative PCR for DNA levels of pathogens related to periodontal disease (Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, Actinobacillus actinomycetemcomitans) and dental caries (Streptococcus mutans and S. sobrinus). There were no consistent associations between DNA levels of selected bacterial species and gastric precancerous lesions, although an elevated but non-significant odds ratio (OR) for gastric precancerous lesions was observed in relation to increasing colonization of A. actinomycetemcomitans (OR = 1.36 for one standard deviation increase, 95% Confidence Interval = 0.87-2.12), P. gingivalis (OR = 1.12, 0.67-1.88) and T. denticola (OR = 1.34, 0.83-2.12) measured in plaque. To assess the influence of specific long-term infection, stratified analyses by levels of periodontal indices were conducted. A. actinomycetemcomitans was significantly associated with gastric precancerous lesions (OR = 2.51, 1.13-5.56) among those with ≥ median of percent tooth sites with PD ≥ 3 mm, compared with no association among those below the median (OR = 0.86, 0.43-1.72). A significantly stronger relationship was observed between the cumulative bacterial burden score of periodontal disease-related pathogens and gastric precancerous lesions among those with higher versus lower levels of periodontal disease indices (p-values for interactions: 0.03-0.06). Among individuals with periodontal disease, high levels of colonization of periodontal pathogens are associated with an increased risk of gastric precancerous lesions.
authors: Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY, USA.
authors: Christian R
authors: CR
authors: Salazar
authors: Jinghua
authors: J
authors: Sun
authors: Yihong
authors: Y
authors: Li
authors: Fritz
authors: F
authors: Francois
authors: Patricia
authors: P
authors: Corby
authors: Guillermo
authors: G
authors: Perez-Perez
authors: Ananda
authors: A
authors: Dasanayake
authors: Zhiheng
authors: Z
authors: Pei
authors: Yu
authors: Y
authors: Chen
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D004269:DNA, Bacterial / Q000302:isolation & purification; D003731:Dental Caries / Q000150:complications / Q000382:microbiology*; D003773:Dental Plaque / Q000150:complications / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000150:complications / Q000382:microbiology*; D010512:Periodontal Index; D011230:Precancerous Conditions / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D012307:Risk Factors; D012463:Saliva / Q000382:microbiology; D013270:Stomach / Q000382:microbiology / Q000473:pathology*; D013274:Stomach Neoplasms / Q000209:etiology / Q000382:microbiology* / Q000473:pathology
chemical_list: D004269:DNA, Bacterial