title: 7q36 deletion and 9p22 duplication: effects of a double imbalance.
abstract: The etiology of mental retardation/developmental delay (MRDD) remains a challenge to geneticists and clinicians and can be correlated to environmental and genetic factors. Chromosomal aberrations are common causes of moderate to severe mental retardation and may represent 10% of these occurrences. Here we report the case of a boy with development delay, hypoplasia of corpus callosum, microcephaly, muscular hypotonia, and facial dysmorphisms. A deletion of 7q36.1 → 36.3 and duplication of 9p22.3 → 23 was detected as a result of an unbalanced translocation of paternal origin. Breakpoint delimitation was achieved with array comparative genomic hybridization assay. Additional multiplex ligation dependent probe amplification (MLPA) analyzes confirmed one copy loss of 7q36.3 region and one copy gain of 9p24.3 region. Patient resultant phenotype is consistent with the already described findings for both 7q deletion and 9p duplication syndromes.
authors: Research and Development Institute, Fleury Group, Av, Gal Valdomiro de Lima, 508, São Paulo, SP, Zip Code: 04344-070, Brazil. mlourdes.chauffaille@grupofleury.com.br.
authors: Karla de Oliveira
authors: Kde O
authors: Pelegrino
authors: Sofia
authors: S
authors: Sugayama
authors: Ana Lúcia
authors: AL
authors: Catelani
authors: Karina
authors: K
authors: Lezirovitz
authors: Fernando
authors: F
authors: Kok
authors: Maria de Lourdes
authors: Mde L
authors: Chauffaille