title: Polyoxometalate-biomolecule conjugates: a new approach to create hybrid drugs for cancer therapeutics.
abstract: Some polyoxometalate (POM) clusters have demonstrated attractive anticancer properties. Unfortunately, their cytotoxicity upon normal cell is one of fateful side effects obstructing their further clinic application as inorganic drugs. In this communication, we report a new approach to create hybrid drugs potentially for cancer therapeutics. At first, the POM cluster bioconjugates were created by attaching the bioactive ligands on an amine grafted POM via simple amidation reaction. The cytotoxicity study with breast cancer cells (MCF-7 and MDA-MB-231) and non-cancerous breast epithelial cell (MCF-10A) showed that rationally selected ligands with cancer-cell targeting ability on POM-biomolecule conjugates can impart enhanced anti-tumor activity and selectivity, thus representing a new concept to develop novel POM-biomolecule hybrid drugs with the potential synergistic effect: increased bioactivity and lower side effect.
authors: Center for Synthetic Soft Materials, Key Laboratory of Functional Polymer Materials of Ministry of Education and Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.
authors: Hai-Kuan
authors: HK
authors: Yang
authors: Yi-Xing
authors: YX
authors: Cheng
authors: Ming-Ming
authors: MM
authors: Su
authors: Yu
authors: Y
authors: Xiao
authors: Min-Biao
authors: MB
authors: Hu
authors: Wei
authors: W
authors: Wang
authors: Qian
authors: Q
authors: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy; D002412:Cations / Q000737:chemistry; D045744:Cell Line, Tumor; D015195:Drug Design; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D017973:Tungsten Compounds / Q000737:chemistry* / Q000494:pharmacology*; D000099294:Polyoxometalates
chemical_list: D000970:Antineoplastic Agents; D002412:Cations; D009942:Organometallic Compounds; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates