title: The Athens TAVR Registry of newer generation transfemoral aortic valves: 30-day outcomes.
abstract: BACKGROUND
  Transcatheter aortic valve replacement (TAVR) is a documented treatment for patients with symptomatic aortic stenosis who are at very high or prohibitive operative risk. We sought to investigate the outcomes of transfemoral procedures with the newer generation valves in four TAVR centres in Athens, Greece.
  
  
  METHODS
  The ATHENS TAVR Registry included all patients who underwent transfemoral implantation of the newer generation valves in 4 Athens TAVR centres (self-expanding valve 67 patients, balloon-expandable valve 59 patients). We present the procedural and echocardiographic data and the 30-day clinical outcomes according to valve type.
  
  
  RESULTS
  A total of 126 patients underwent 126 procedures (67 CoreValve, Medtronic; 59 SAPIEN XT, Edwards Lifesciences). The mean age and logistic EuroSCORE were 80 ± 8 years and 25 ± 13%. The procedural and device success rates were 100% and 98%, respectively. The 30-day mortality was 1% (n=1), the major vascular event rates 9% (similar for both valve types), and a new permanent pacemaker was implanted more often during the same hospitalisation after CoreValve (33% vs. 9%, p=0.001). The mean effective aortic valve area increased and the mean transvalvular pressure gradient declined post implantation (from 0.66 ± 0.15 cm(2) to 1.61 ± 0.43 cm(2), p<0.001; from 51 ± 14 mm Hg to 10 ± 3 mm Hg, p<0.001). The mean grade of aortic insufficiency increased after CoreValve (from 1.2 ± 0.6 to 1.5 ± 0.7, p=0.03) but remained stable after SAPIEN XT (1.0 ± 0.8 and 1.0 ± 0.6, p=0.88) implantation.
  
  
  CONCLUSIONS
  TAVR outcomes with both the newer generation transfemoral valves in the ATHENS Registry were excellent. We observed a greater need for a new permanent pacemaker and a greater degree of aortic valve insufficiency after CoreValve implantation.
authors: THV Department, Hygeia Hospital, Athens, Greece. spargias@hygeia.gr
authors: Konstantinos
authors: K
authors: Spargias
authors: Konstantinos
authors: K
authors: Toutouzas
authors: Michael
authors: M
authors: Chrissoheris
authors: Andreas
authors: A
authors: Synetos
authors: Antonis
authors: A
authors: Halapas
authors: Ioannis
authors: I
authors: Paizis
authors: Georgios
authors: G
authors: Latsios
authors: Konstantinos
authors: K
authors: Stathogiannis
authors: Konstantinos
authors: K
authors: Stathogianni
authors: Spyridon
authors: S
authors: Papametzelopoulos
authors: Stavros
authors: S
authors: Zanos
authors: Gregory
authors: G
authors: Pavlides
authors: Achileas
authors: A
authors: Zacharoulis
authors: Aias
authors: A
authors: Antoniades
authors: Christodoulos
authors: C
authors: Stefanadis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D004452:Echocardiography; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D006115:Greece; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D006801:Humans; D008297:Male; D012042:Registries; D016896:Treatment Outcome