title: Importance of the infusion rate for the plasma expanding effect of 5% albumin, 6% HES 130/0.4, 4% gelatin, and 0.9% NaCl in the septic rat.
abstract: OBJECTIVE
  To compare the plasma volume (PV) expanding effect of a fast infusion rate with that of a slow infusion rate of a fixed volume of 5% albumin, of the synthetic colloids, 6% hydroxyethyl starch 130/0.4 and 4% gelatin, and of 0.9% NaCl in a rat sepsis model and to compare the plasma-expanding effect among these fluids.
  
  
  METHODS
  Prospective, randomized animal study.
  
  
  METHODS
  University hospital laboratory.
  
  
  METHODS
  One hundred and twelve adult male rats.
  
  
  METHODS
  Sepsis was induced by cecal ligation and incision followed by closure of the abdomen. After 3 hrs, an infusion of the PV expander under study was started at a volume of 12mL/kg for the colloids and of 48mL/kg for 0.9% NaCl, either for 15 mins or for 3 hrs. A control group underwent the same experimental procedure but no fluid was given.
  
  
  RESULTS
  Three hours after start of the infusion (end of experiment), the plasma-expanding effect was better with a slow than a fast infusion rate for the colloids, especially albumin, but the NaCl groups did not differ significantly from the control group. The PV for the control group was 28.7±3mL/kg. In the slow and the fast infusion groups, it was 38.9±4.3 and 32.6±4.2mL/kg for albumin (p < 0.001), 32.9±4.3 and 29.5±4.4mL/kg for hydroxyethyl starch 130/0.4 (p < 0.05), 31.8±3.9 and 28.2±4.1mL/kg for gelatin (p < 0.05), and 31.8±5.3 and 30.7±6.6mL/kg for NaCl (n.s), respectively.
  
  
  CONCLUSIONS
  The study showed that the PV expansion by a colloid was greater when given at a slow than at a fast infusion rate, an effect more pronounced for albumin. This difference was not seen for NaCl. The PV-expanding effect was poor for NaCl and better for albumin than for the other colloids.
authors: Department of Anesthesia and Intensive Care, Lund University and Lund University Hospital, Lund, Sweden.
authors: Björn P
authors: BP
authors: Bark
authors: Johan
authors: J
authors: Persson
authors: Per-Olof
authors: PO
authors: Grände
mesh_terms: D000418:Albumins / Q000008:administration & dosage*; D000818:Animals; D001810:Blood Volume / Q000502:physiology*; D003102:Colloids; D005780:Gelatin / Q000008:administration & dosage*; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D008297:Male; D010952:Plasma Substitutes / Q000008:administration & dosage*; D011446:Prospective Studies; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D018805:Sepsis / Q000503:physiopathology*; D012965:Sodium Chloride / Q000008:administration & dosage*; D013548:Sweden; D013997:Time Factors
chemical_list: D000418:Albumins; D003102:Colloids; C485123:HES 130-0.4; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D012965:Sodium Chloride; D005780:Gelatin