title: Evaluation of IL-12 serum level in patients with recalcitrant multiple common warts, treated by intralesional tuberculin antigen.
abstract: BACKGROUND
  No universal consensus about optimal modality for treating the recalcitrant multiple common warts (RMCW).
  
  
  OBJECTIVE
  To evaluate the immunological mechanisms and clinical therapeutic effect of using of intralesional purified protein derivative (PPD) in the treatment of RMCW.
  
  
  METHODS
  The study included 40 patients with RMCW. They were randomly assigned to 2 groups: first group (20 patients) received intralesional PPD antigen, and second group (20 patients) received intralesional saline as a control group. In both groups, injections were made into single lesions, or largest wart in case of multiple lesions, at weekly intervals, until complete clearance or for a maximum of six treatments. Blood serum was taken at pre-study and at week 6 to measure IL-12 level.
  
  
  RESULTS
  A significant difference was found between the therapeutic responses of RMCW to PPD antigen and saline control group (p < 0.001). In the PPD group, complete response was achieved in 75% after 5.8 ± 0.7 sessions' patients presenting with RMCW. There was a statistically significant increase in IL-12 of PPD group versus saline group. No recurrence was observed in the PPD group.
  
  
  CONCLUSIONS
  Intralesional immunotherapy by PPD antigen is an effective and a safe treatment for RMCW in previously immunized patients.
authors: Department of Dermatology and Andrology, Faculty of Medicine, Suez Canal University , Ismailia , Egypt.
authors: Fian M A
authors: FM
authors: Abd-Elazeim
authors: Ghada F A
authors: GF
authors: Mohammed
authors: Amal
authors: A
authors: Fathy
authors: Roshdy W
authors: RW
authors: Mohamed
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D002648:Child; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D018664:Interleukin-12 / Q000097:blood*; D008297:Male; D016896:Treatment Outcome; D014373:Tuberculin / Q000008:administration & dosage*; D014611:Vaccination; D014860:Warts / Q000097:blood* / Q000276:immunology / Q000628:therapy*; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D014373:Tuberculin; D018664:Interleukin-12