title: One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment.
abstract: The discovery of tissue reparative and immunosuppressive abilities of mesenchymal stem cells (MSCs) has drawn more attention to tumor microenvironment and its role in providing the soil for the tumor cell growth. MSCs are recruited to tumor which is referred as the never healing wound and altered by the inflammation environment, thereby helping to construct the tumor microenvironment. The environment orchestrated by MSCs and other factors can be associated with angiogenesis, immunosuppression, inhibition of apoptosis, epithelial-mesenchymal transition (EMT), survival of cancer stem cells, which all contribute to tumor growth and progression. In this review, we will discuss how MSCs are recruited to the tumor microenvironment and what effects they have on tumor progression.
authors: Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medicial University, 225 Changhai Road, Shanghai 200438, China. lixinwei@smmu.edu.cn.
authors: Xue
authors: X
authors: Yang
authors: Jing
authors: J
authors: Hou
authors: Zhipeng
authors: Z
authors: Han
authors: Ying
authors: Y
authors: Wang
authors: Chong
authors: C
authors: Hao
authors: Lixin
authors: L
authors: Wei
authors: Yufang
authors: Y
authors: Shi