title: Sub-chronic exposure to chlorpyrifos induces hematological, metabolic disorders and oxidative stress in rat: attenuation by glutathione.
abstract: The current work aimed to investigate the different toxic effects of chlorpyrifos (CPF) in subchronic exposure. Two groups of Sprague-Dawley male rats were exposed to CPF alone in a dose of 30 mg/kg body weight, or CPF dose as previous plus glutathione (GSH) in a dose of 100 mg/kg body weight, for 90 days, twice weekly, orally. Another two groups of rat were given corn oil (control) or GSH. There is a significant decrease in hemoglobin concentration, haematocrit percentage, thrombocytic indices, total protein and albumin levels in CPF-exposed group. CPF induced hyperglycemia and significant increase in total cholesterol, but a significant decrease in triglyceride levels was obtained. A significant increase in the levels of lipid peroxidation was obtained while a significant decrease of the total antioxidant was recorded. The decrease in glycogen content and some histopathological changes were observed in liver after CPF exposure. Furthermore, co-administration of GSH can restore some of these alterations.
authors: Department of Forensic Medicine and Toxicology Faculty of Veterinary Medicine, Assuit University, Egypt. medicine1971@yahoo.com
authors: Eman E
authors: EE
authors: Elsharkawy
authors: Doha
authors: D
authors: Yahia
authors: Neveen A
authors: NA
authors: El-Nisr
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism; D001769:Blood / Q000187:drug effects* / Q000378:metabolism; D004390:Chlorpyrifos / Q000633:toxicity*; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism* / Q000494:pharmacology; D006003:Glycogen / Q000378:metabolism; D006943:Hyperglycemia / Q000139:chemically induced; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D059550:Toxicity Tests, Subchronic / Q000379:methods; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D014280:Triglycerides; D006003:Glycogen; D002784:Cholesterol; D005978:Glutathione; D004390:Chlorpyrifos