title: Attenuated Salmonella typhimurium carrying the hepatocyte growth factor and keratinocyte growth factor genes repairs gastrointestinal mucosal damage caused by chemotherapy.
abstract: Radiotherapy and chemotherapy are the main therapeutic approaches for patients with malignant tumours, especially advanced tumours. However, they can cause adverse effects, one of which is gastrointestinal mucosal damage, which can greatly affect patients' quality of life. Until now, there have been no effective therapies to avoid or treat these adverse effects. In this study, we used attenuated Salmonella typhimurium (S. typhimurium) to deliver the hepatocyte growth factor (HGF) or keratinocyte growth factor (KGF) to murine gastrointestinal mucosa. We found that attenuated S. typhimurium carrying the HGF or KGF genes can effectively reduce the ratio of tumour to non-tumour carcass weight, repair damage to the gastrointestinal mucosal from chemotherapy, improve the immune response, and reduce the mortality rate of mice. Oral administration of attenuated S. typhimurium with HGF and KGF may be promising as a way of improving the quality of life of patients undergoing radiotherapy and chemotherapy.
authors: Department of Oncology, The First Affiliated Hospital of General Hospital of Chinese PLA, Beijing 100853, China.
authors: Jun-Zhong
authors: JZ
authors: Sun
authors: Xiao-Qin
authors: XQ
authors: Ha
authors: Li-Ming
authors: LM
authors: Zhang
authors: Hai-Bin
authors: HB
authors: Wang
authors: Hong-Wei
authors: HW
authors: Wang
authors: Hai-Feng
authors: HF
authors: Duan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy*; D005260:Female; D051523:Fibroblast Growth Factor 7 / Q000235:genetics*; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D017228:Hepatocyte Growth Factor / Q000235:genetics*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011878:Radiotherapy / Q000009:adverse effects; D012486:Salmonella typhimurium; D014162:Transfection
chemical_list: D000970:Antineoplastic Agents; D051523:Fibroblast Growth Factor 7; D017228:Hepatocyte Growth Factor