title: Ambulatory systolic-diastolic pressure regression index predicts acute coronary syndromes.
abstract: OBJECTIVE
  Ambulatory systolic-diastolic pressure regression index (ASDPRI) is a composite marker of cardiovascular properties. The study was conducted to investigate the relationship between ASDPRI and cardiovascular events in patients with significant coronary atherosclerosis confirmed in angiography.
  
  
  METHODS
  Associations between ASDPRI and cardiovascular events were examined in 891 subjects referred for diagnostic coronary angiography. ASDPRI was calculated as 1 minus the slope of the linear relation between 24-h DBP and 24-h SBP.
  
  
  RESULTS
  During follow-up (median 6.7 years), 135 acute coronary syndromes (ACS), including five deaths and 55 strokes occurred in the studied group. There was a higher 24-h ASDPRI in patients with ACS than in patients with no ACS (0.35 ± 01 vs 0.30 ± 0.1, p < 0.01); 24-h ASDPRI was the independent predictor for ACS (OR = 4.0; 95% CI 1.3-12.0).
  
  
  CONCLUSIONS
  ASDPRI has an important role as a risk factor of ACS in patients with coronary atherosclerosis.
authors: Department of Cardiology, Medical University of Gdansk, Debinki 7, 80-211 Gdansk, Poland.
authors: Wojciech
authors: W
authors: Sobiczewski
authors: Marcin
authors: M
authors: Wirtwein
authors: Marcin
authors: M
authors: Gruchala
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003971:Diastole / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013599:Systole / Q000502:physiology