title: Bioengineered probiotics, a strategic approach to control enteric infections.
abstract: Enteric infections account for high morbidity and mortality and are considered to be the fifth leading cause of death at all ages worldwide. Seventy percent of all enteric infections are foodborne. Thus significant efforts have been directed toward the detection, control and prevention of foodborne diseases. Many antimicrobials including antibiotics have been used for their control and prevention. However, probiotics offer a potential alternative intervention strategy owing to their general health beneficial properties and inhibitory effects against foodborne pathogens. Often, antimicrobial probiotic action is non-specific and non-discriminatory or may be ineffective. In such cases, bioengineered probiotics expressing foreign gene products to achieve specific function is highly desirable. In this review we summarize the strategic development of recombinant bioengineered probiotics to control enteric infections, and to examine how scientific advancements in the human microbiome and their immunomodulatory effects help develop such novel and safe bioengineered probiotics.
authors: Molecular Food Microbiology Laboratory; Department of Food Science; Purdue University; West Lafayette, IN USA; Department of Comparative Pathobiology; Purdue University; West Lafayette, IN USA.
authors: Mary Anne Roshni
authors: MA
authors: Amalaradjou
authors: Molecular Food Microbiology Laboratory; Department of Food Science; Purdue University; West Lafayette, IN USA; Department of Comparative Pathobiology; Purdue University; West Lafayette, IN USA.
authors: Arun K
authors: AK
authors: Bhunia
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D057005:Bioengineering; D001709:Biotechnology; D005524:Food Technology / Q000379:methods*; D005517:Foodborne Diseases / Q000517:prevention & control*; D006801:Humans; D023421:Models, Animal; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology*; D013312:Stress, Physiological
chemical_list: D000890:Anti-Infective Agents
keywords: bioengineered probiotics; enteric infections; foodborne diseases; lactic acid bacteria; probiotics; recombinant probiotics