title: Dexmedetomidine use in direct laryngoscopic biopsy under TIVA.
abstract: BACKGROUND
  The purpose of this study is to investigate the suitability of dexmedetomidine as a helpful sedative agent in direct laryngoscopic biopsy (DLB), under total intravenous anesthesia (TIVA).
  
  
  METHODS
  In this double blind randomised study, patients were allocated to receive dexmedetomidine 0.5 microg/kg (group D, n = 20) or saline placebo (group P, n = 20) intravenously. Forty ASA I-III patients were infused propofol and administered rocuronium bromur. They were intubated and performed biopsy. Aldrete scores, intraoperative propofol and postoperative analgesic requirements, satisfaction scores, recovery time, Ramsay sedation scale (RSS), haemodynamic changes and side effects were recorded.
  
  
  RESULTS
  Postoperative analgesic requirement in group D was significantly lower and satisfaction scores and RSS were significantly higher than in group P. Additionally, MAP (mean arterial blood pressure) significantly decreased at post-extubation time in group D.
  
  
  CONCLUSIONS
  The premedication with a single dose of dexmedetomidine decreases intraoperative propofol and postoperative analgesic requirements, increases the postoperative satisfaction and RSS considerably in patients undergoing DLB under TIVA.
authors: Anesthesiology and Reanimation, Gaziantep University School of Medicine Gaziantep/Turkey. aysemizrak@mynet.com
authors: Ayse
authors: A
authors: Mizrak
authors: Maruf
authors: M
authors: Sanli
authors: Semsettin
authors: S
authors: Bozgeyik
authors: Rauf
authors: R
authors: Gul
authors: Suleyman
authors: S
authors: Ganidagli
authors: Elif
authors: E
authors: Baysal
authors: Unsal
authors: U
authors: Oner
mesh_terms: D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use; D000732:Androstanols / Q000008:administration & dosage; D000771:Anesthesia, Intravenous / Q000379:methods; D001706:Biopsy; D001794:Blood Pressure; D020927:Dexmedetomidine / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007822:Laryngeal Neoplasms / Q000175:diagnosis*; D007828:Laryngoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control; D015742:Propofol / Q000008:administration & dosage; D000077123:Rocuronium
chemical_list: D000700:Analgesics; D000732:Androstanols; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D000077123:Rocuronium; D015742:Propofol