title: Serum IGF-1 levels correlate negatively to liver damage in diabetic rats.
abstract: Diabetes and insulin resistance frequently cause liver damage. Diabetes also causes reduction in liver and blood IGF-1 levels. We investigated the relation between liver damage and IGF-1 levels in diabetic rats. Fourteen Wistar albino rats were divided into control and diabetic groups. Diabetes was induced by streptozotocin. Rats were sacrificed for biochemical and histologic examinations 2 weeks after streptozotocin injection. Serum and liver IGF-1 levels were decreased, liver malondialdehyde (MDA) levels were increased, glutathione peroxidase (GPx) enzymes activities were decreased and serum alanine aminotransferase (ALT) levels were increased in diabetic group. Microscopic examination of liver revealed that normal tissue organization was disrupted in streptozotocin-induced diabetic rats. There was a strongly positive correlation between blood glucose levels and liver injury, and blood and liver IGF-1 levels. There was a strongly negative correlation between blood IGF-1 levels and hepatic injury. Our results suggest that reduction of blood IGF-1 levels correlates with hepatic injury and circulating IGF-1 levels may have predictive value for determining hepatic damage that results from diabetes. In addition, circulating IGF-1 levels are correlated with glutathione levels and the oxidative stress status of diabetic rat liver.
authors: Dokuz Eylul University, Medical Faculty, Physiology, Izmir, Turkey.
authors: Ilkay
authors: I
authors: Aksu
authors: Basak
authors: B
authors: Baykara
authors: Muge
authors: M
authors: Kiray
authors: Tugba
authors: T
authors: Gurpinar
authors: Ali Riza
authors: AR
authors: Sisman
authors: Nuran
authors: N
authors: Ekerbicer
authors: Aysegul
authors: A
authors: Tas
authors: Ozden
authors: O
authors: Gokdemir-Yazar
authors: Nazan
authors: N
authors: Uysal
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D008315:Malondialdehyde; D007334:Insulin-Like Growth Factor I; D005979:Glutathione Peroxidase; D000410:Alanine Transaminase; D005978:Glutathione