title: Five new phenolic glycosides from Hedyotis scandens.
abstract: Five new phenolic glycosides, hedyotosides A-E (1-5), including a new cyanogenic glycoside (1), along with 10 known compounds (6-15) were isolated from the whole plants of Hedyotis scandens. The structures of compounds 1-5 were established by extensive spectroscopic analyses and acid hydrolysis. All the isolated compounds were evaluated for their in vitro antiviral activity against respiratory syncytial virus (RSV) with cytopathic effect (CPE) reduction assay. Compounds 6 and 15 showed anti-RSV effects with IC(50) values of 20 and 25 μg/mL, respectively.
authors: Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China. twangguocai@jnu.edu.cn
authors: Guo-Cai
authors: GC
authors: Wang
authors: Tao
authors: T
authors: Li
authors: Fang-Ye
authors: FY
authors: Deng
authors: Yao-Lan
authors: YL
authors: Li
authors: Wen-Cai
authors: WC
authors: Ye
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D032064:Hedyotis / Q000737:chemistry*; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D012136:Respiratory Syncytial Viruses / Q000187:drug effects / Q000502:physiology
chemical_list: D000998:Antiviral Agents; D006027:Glycosides; D010636:Phenols