title: Recent progress in biological activities and synthetic methodologies of pyrroloquinoxalines.
abstract: Pyrroloquinoxalines have proved to be a very attractive scaffold for medicinal chemist in the recent past. These compounds were extensively studied as bioactive compounds and many of them are known to be biologically and medicinally useful molecules, such as anti-HIV agents, antimalarial agents, antagonist agents, anticancer agents, and PARP-1 inhibitors. Additionally, pyrroloquinoxalines are also important intermediates for the construction of 5-HT3 receptor agonists. In this review the developments in biological activities and synthetic methodologies of pyrroloquinoxalines are discussed.
authors: School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P R China.
authors: Aiping
authors: A
authors: Huang
authors: Chen
authors: C
authors: Ma
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008670:Metals / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors / Q000378:metabolism; D011758:Pyrroles / Q000737:chemistry*; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; D008670:Metals; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011758:Pyrroles; D011810:Quinoxalines; D011065:Poly(ADP-ribose) Polymerases; D051057:Proto-Oncogene Proteins c-akt