title: Tricycloalternarenes F-H: three new mixed terpenoids produced by an endolichenic fungus Ulocladium sp. using OSMAC method.
abstract: Three new mixed terpenoids, tricycloalternarenes (TCAs) F-H (1-3), together with ten known tricycloalternarenes (4-13), were isolated from the Czapek's culture of an endophytic fungus Ulocladium sp. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data. TCA 1b (5) showed weak activity against the Bacille Calmette-Guerin strain with the MIC of 125μg/mL. TCA 9b (10) exhibited strong cytotoxic activity against Hela cell line with IC50 of 8.58μM.
authors: School of Life Science, University of Science and Technology of China, Hefei 230026, PR China.
authors: Quan-Xin
authors: QX
authors: Wang
authors: Li
authors: L
authors: Bao
authors: Xiao-Li
authors: XL
authors: Yang
authors: Hui
authors: H
authors: Guo
authors: Biao
authors: B
authors: Ren
authors: Liang-Dong
authors: LD
authors: Guo
authors: Fu-Hang
authors: FH
authors: Song
authors: Wen-Zhao
authors: WZ
authors: Wang
authors: Hong-Wei
authors: HW
authors: Liu
authors: Li-Xin
authors: LX
authors: Zhang
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification*; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D001203:Ascomycota / Q000737:chemistry*; D046508:Culture Techniques; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008011:Lichens / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D004224:Diterpenes