title: 5HTTLPR: White Knight or Dark Blight?
abstract: In over 100 neuroscience genetics reports on SLC6A4 published in the first part of 2012, >40% reported data from genotyping only the serotonin transporter-linked promoter region [5HTTLPR] indel, omitting genotyping of two nearby SNPs that substantially alter 5HTTLPR allele frequencies and functionality. And 25% of these papers did not report ethnicity of the subjects genotyped, another factor that alters allele frequencies. This field thus seems stultified. Improved science for the present and future will be better served by attention to more complete methods for genotyping and subject sample reporting.
authors: Laboratory of Clinical Science, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States. dennismurphy@mail.nih.gov
authors: Dennis L
authors: DL
authors: Murphy
authors: Michelle S
authors: MS
authors: Maile
authors: Nicholas M
authors: NM
authors: Vogt
mesh_terms: D001008:Anxiety Disorders / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D010554:Personality Disorders / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins