title: The enhancement of radiosensitivity in human esophageal squamous cell carcinoma cells by zoledronic acid and its potential mechanism.
abstract: Esophageal squamous cell carcinoma (ESCC) has a low 5-year patient survival rate. Radiotherapy, as a preoperative or postoperative treatment of surgery, has a crucial role in improving local control and survival of ESCC. Various chemotherapeutic and biologic agents have been used as radio-sensitizers in combination with radiotherapy. Here, we demonstrate that zoledronic acid (ZOL) has a radio-sensitizing effect on ESCC cells. Exposure of ESCC cancer cells to ZOL plus radiation resulted in increased cell death through arresting the cell cycle between S and G2/M phases. ZOL appeared to inhibit proliferation, tube formation and invasion of endothelial cells. These anti-angiogenetic effects were more marked concurrently with irradiation. In addition, synergistic suppressive effects on VEGF expression were observed after combined treatment. Our data suggest that the combination of ZOL and radiation is a promising therapeutic strategy to enhance radiation therapy for ESCC patients.
authors: Department of Pharmacy, Luohe Medical College, 148 Daxue-Road, Luohe, 462002, China, youyanjie@163.com.
authors: Yanjie
authors: Y
authors: You
authors: Jianfeng
authors: J
authors: Liu
authors: Zhizhong
authors: Z
authors: Wang
authors: Yuan
authors: Y
authors: Zhang
authors: Yonggang
authors: Y
authors: Ran
authors: Xu
authors: X
authors: Guo
authors: Huimin
authors: H
authors: Liu
authors: Haibo
authors: H
authors: Wang