title: Rotational thromboelastometry and standard coagulation tests for live liver donors.
abstract: OBJECTIVE
  To study coagulation of live liver donors with standard coagulation tests (SCT) and rotational thromboelastometry (ROTEM) and investigate their relationship.
  
  
  METHODS
  A descriptive prospective study involving 50 right hepatotomy donors with epidural catheters. ROTEM (EXTEM, INTEM, and FIBTEM represent extrinsic and intrinsic pathways of coagulation and fibrinogen activity, respectively) was measured perioperatively and on days 1, 3, 5, 10, and 30. SCTs include prothrombin time (PT), international normalized ratio (INR) of PT, activated partial thromboplastin time (aPPT), fibrinogen, and platelets.
  
  
  RESULTS
  PT and INR reflect hypocoagulability reaching maximum on day one (16.9 ± 2.5 s, 1.4 ± 0.2, p < 0.05 compared with baseline). ROTEM was in normal ranges till day 30 with no hypercoagulability. Fibrinogen showed no correlation with maximum clot firmness (MCF) of FIBTEM (r = 0.35, p > 0.05). CFT of EXTEM was not in significant correlation with PT and INR (r = 0.16, 0.19, p > 0.05), respectively. Significant correlation between platelets and both MCF (EXTEM; r = 0.59, p = 0.004) and MCF (INTEM; r = 0.48, p = 0.027).
  
  
  CONCLUSIONS
  ROTEM disagreed with SCTs and did not show the temporary hypocoagulability suggested by SCTs. Both ROTEM and SCTs showed no signs of hypercoagulability. Future studies involving ROTEM could help develop new guidelines for coagulation monitoring.
authors: Department of Anaesthesia, Cairo University, Cairo, Egypt.
authors: Maged
authors: M
authors: Mohammed
authors: Nirmeen
authors: N
authors: Fayed
authors: Ashraf
authors: A
authors: Hassanen
authors: Fatma
authors: F
authors: Ahmed
authors: Wessam
authors: W
authors: Mourad
authors: Maha
authors: M
authors: El Sheikh
authors: Fawzia
authors: F
authors: Abofetouh
authors: Khaled
authors: K
authors: Yassen
authors: Magdy
authors: M
authors: Khalil
authors: Ibrahim
authors: I
authors: Marwan
authors: Koichio
authors: K
authors: Tanaka
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D001780:Blood Coagulation Tests; D003430:Cross-Sectional Studies; D005260:Female; D006498:Hepatectomy; D006801:Humans; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D017063:Outcome Assessment, Health Care; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis*; D011446:Prospective Studies; D013916:Thrombelastography / Q000379:methods*; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology