title: Novel anti-inflammatory phytoconstituents from Desmodium gangeticum.
abstract: A new aliphatic enone, (17Z,20Z)-hexacosa-17,20-dien-9-one (3), and one new bisindole alkaloid, gangenoid (6), together with seven known compounds were isolated from the roots and aerial parts of Desmodium gangeticum (family: Leguminosae). All the compounds except 2 and 7 were isolated from this plant for the first time, which may be of chemotaxonomic importance. Structures of compounds 3 and 6 were determined on the basis of their detailed spectroscopic analyses (NMR, IR and mass). In addition, compounds 3 and 6 were investigated for their effects on lipopolysaccharide-stimulated macrophages for the production of pro-inflammatory cytokines such as tumour necrosis factor-α and interleukin-6.
authors: a Analytical Chemistry Department , CSIR-Central Institute of Medicinal and Aromatic Plants , Lucknow , India.
authors: Akhilesh
authors: A
authors: K Yadav
authors: Jyoti
authors: J
authors: Agrawal
authors: Anirban
authors: A
authors: Pal
authors: Madan M
authors: MM
authors: Gupta
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D002478:Cells, Cultured; D007887:Fabaceae / Q000737:chemistry*; D015850:Interleukin-6 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha