title: OGTT results in obese adolescents with normal HOMA-IR values.
abstract: OBJECTIVE
  To investigate insulin resistance (IR) with OGTT in obese adolescents who have normal fasting insulin and homeostasis model assessment for insulin resistance (HOMA-IR).
  
  
  METHODS
  A total of 97 obese adolescents who had values of HOMA-IR <3.16 and insulin levels <18 μU/mL (125 pmol/L) were included in the study.
  
  
  METHODS
  Oral glucose tolerance test (OGTT) was performed on all cases. Subjects were divided into two groups: subjects with and without IR using an insulin peak of ≥150 μU/mL (1041.8 pmol/L) and/or ≥75 μU/mL (520.9 pmol/L) 120 min after glucose charge and the sum of insulin levels >2083.5 pmol/L (300 μU/mL) in OGTT. IR risk factors were defined as family history of diabetes mellitus, acanthosis nigricans (AN), and hepatic steatosis.
  
  
  RESULTS
  IR was detected in 61 (62.9%) patients. The IR group had significantly more frequent AN (p=0.0001). As the number of risk factors increased, the frequency of IR also increased (p=0.01).
  
  
  CONCLUSIONS
  We advise to perform OGTT in obese adolescents with normal HOMA-IR, if they have risk factors for IR.
authors: School of Medicine, Baskent University, Bahcelievler, Ankara, Turkey. nursel_m_sahin@yahoo.com.tr
authors: Nursel Muratoglu
authors: NM
authors: Sahin
authors: Sibel Tulgar
authors: ST
authors: Kinik
authors: Mustafa Agah
authors: MA
authors: Tekindal
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism*; D005951:Glucose Tolerance Test / Q000379:methods / Q000592:standards; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism*; D012016:Reference Values; D015203:Reproducibility of Results; D012307:Risk Factors
chemical_list: D007328:Insulin