title: Dibenzocyclooctadiene lignans and norlignans from fruits of Schisandra wilsoniana.
abstract: Seven new dibenzocyclooctadiene lignans, marlignans M-S (1-7), four new norlignans, marphenols C-F (8-11), and 21 known compounds (12-32) were isolated from the fruits of Schisandra wilsoniana. The structures of 1-11 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques and CD experiments. Compounds 1-11 were evaluated for their anti-HIV activities and showed EC(50) values in the range 2.97-6.18 μg/mL and therapeutic index values of 5.33-29.13.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
authors: Guang-Yu
authors: GY
authors: Yang
authors: Rui-Rui
authors: RR
authors: Wang
authors: Huai-Xue
authors: HX
authors: Mu
authors: Yin-Ke
authors: YK
authors: Li
authors: Xiao-Nian
authors: XN
authors: Li
authors: Liu-Meng
authors: LM
authors: Yang
authors: Yong-Tang
authors: YT
authors: Zheng
authors: Wei-Lie
authors: WL
authors: Xiao
authors: Han-Dong
authors: HD
authors: Sun
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D034242:Cyclooctanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D015497:HIV-1 / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032141:Schisandra / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal; D017705:Lignans; C511097:dibenzocyclooctadiene