title: Resistance training increases SHBG in overweight/obese, young men.
abstract: OBJECTIVE
  Evidence suggests that SHBG affects glycemic control, predicts both T2D and metabolic syndrome, and is low in obese subjects. We sought to determine if resistance exercise training (RT) can increase sex hormone-binding globulin (SHBG) and ameliorate levels of related steroid hormones in overweight/obese, sedentary young men.
  
  
  METHODS
  36 participants (BMI 31.4 kg/m(2), age 22 years) were randomized into an RT (12 weeks of training, 3/week) or control group (C, 12 weeks no training), and assessed for changes in SHBG, cortisol, testosterone, free testosterone (FT) and free androgen index (FAI). In addition, body composition and oral glucose tolerance testing was performed.
  
  
  RESULTS
  12 weeks of RT increased SHBG (P=0.01) and decreased FAI (P<0.05) and cortisol (P<0.05) compared to C. FT decreased in RT (P=0.01). Total testosterone did not change in either group. These changes were noted without weight loss, and in concert with increases in lean body mass (P=0.0002 vs C) and decreases in glucose area under the curve (AUC) (P=0.004), insulin AUC (P=0.03), and total (P=0.002) and trunk (P=0.003) fat mass in RT.
  
  
  CONCLUSIONS
  In overweight/obese young men, RT increases SHBG and lowers FAI in obese young adult men.
authors: Exercise and Metabolic Disease Research Laboratory, Translational Sciences Section, UCLA School of Nursing, University of California, Los Angeles, CA, USA. croberts@ucla.edu
authors: Christian K
authors: CK
authors: Roberts
authors: Daniel M
authors: DM
authors: Croymans
authors: Najib
authors: N
authors: Aziz
authors: Anthony W
authors: AW
authors: Butch
authors: Cathy C
authors: CC
authors: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001823:Body Composition / Q000502:physiology; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D009765:Obesity / Q000097:blood* / Q000378:metabolism / Q000628:therapy; D050177:Overweight / Q000097:blood* / Q000378:metabolism / Q000628:therapy; D055070:Resistance Training; D012737:Sex Factors; D012738:Sex Hormone-Binding Globulin / Q000032:analysis / Q000378:metabolism*; D013739:Testosterone / Q000097:blood / Q000378:metabolism; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone