title: [Medicamentous protection of lower limb veins in a subacute period of varicophlebitis of the great saphenous vein].
abstract: The study was aimed at determining the dynamics of saphenous veins in patients with varicophlebitis of the great saphenous vein (GSV) in a subacute period (during compression therapy) and at assessing efficacy of 4-month medicamentous protection thereof. We examined a total of 32 patients presenting with the first episode of non-embolic varicophlebitis of the great saphenous vein. The comparison group comprised 16 patients undergoing 4-month compression (degree 2) therapy alone, and the study group patients (n = 16) were subjected to compression therapy combined with a 4-month course of micronized diosmin (1 tablet twice a day). The patients were included into the groups alternately as they attended our medical facility. Duplex scanning before and after the treatment course was used to measure the following parameters: 1) the evening diameter of veins and 2) an increase in the vein's diameter measured overnight as compared to the morning measures - the orthostatic gradient. The obtained results showed that the subacute period of varicophlebitis of the GSV is accompanied and followed by an increase in the diameter of the GSV and SSV and that of their orthostatic gradient, caused by imparted tonicity and viscoelastic properties. Compression therapy alone in the subacute period of varicophlebitis does not provide complete safety of saphenous veins from secondary lesions. Compression therapy combined with a 4-month-long course of taking micronized diosmin increases the efficacy of treatment.
authors: Iu T
authors: IuT
authors: Tsukanov
authors: A Iu
authors: AIu
authors: Tsukanov
authors: A I
authors: AI
authors: Nikolaĭchuk
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D057186:Comparative Effectiveness Research; D003627:Data Interpretation, Statistical; D004145:Diosmin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D048228:Intermittent Pneumatic Compression Devices; D035002:Lower Extremity / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010689:Phlebitis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D020011:Protective Agents / Q000008:administration & dosage; D012501:Saphenous Vein / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D015911:Sclerotherapy / Q000379:methods; D016896:Treatment Outcome; D018616:Ultrasonography, Doppler, Duplex / Q000379:methods*; D014648:Varicose Veins / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D014689:Venous Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*
chemical_list: D020011:Protective Agents; D004145:Diosmin