title: The potential of dual-energy computed tomography for quantitative decomposition of soft tissues to water, protein and lipid in brachytherapy.
abstract: Dosimetric accuracy of radiation treatment planning in brachytherapy depends on knowledge of tissue composition. It has been speculated that soft tissues can be decomposed to water, lipid and protein. The aim of our work is to evaluate the accuracy of such tissue decomposition. Selected abdominal soft tissues, whose average elemental compositions were taken from literature, were decomposed using dual energy computed tomography to water, lipid and protein via the three-material decomposition method. The quality of the decomposition was assessed using relative differences between (i) mass energy absorption and (ii) mass energy attenuation coefficients of the analyzed and approximated tissues. It was found that the relative differences were less than 2% for photon energies larger than 10 keV. The differences were notably smaller than the ones for water as the transport and dose scoring medium. The choice of the water, protein and lipid triplet resulted in negative elemental mass fractions for some analyzed tissues. As negative elemental mass fractions cannot be used in general purpose particle transport computer codes using the Monte Carlo method, other triplets should be used for the decomposition. These triplets may further improve the accuracy of the approximation as the differences were mainly caused by the lack of high-Z materials in the water, protein and lipid triplet.
authors: Radiation Physics, Department of Medical and Health Sciences, Linköping University, SE-581 85 Linköping, Sweden. Alexandr.Malusek@liu.se
authors: A
authors: A
authors: Malusek
authors: M
authors: M
authors: Karlsson
authors: M
authors: M
authors: Magnusson
authors: G Alm
authors: GA
authors: Carlsson
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D000042:Absorption; D000465:Algorithms; D001918:Brachytherapy / Q000379:methods*; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D015233:Models, Statistical; D009010:Monte Carlo Method; D017785:Photons / Q000627:therapeutic use*; D011506:Proteins / Q000737:chemistry*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014867:Water / Q000737:chemistry*
chemical_list: D008055:Lipids; D011506:Proteins; D014867:Water