title: Effects of antiglaucoma drugs on blood flow of optic nerve heads and related structures.
abstract: An association between glaucoma development or progression and compromised ocular blood flow has been postulated as a result of population-based studies and prospective cohort studies. Blood flow in the optic nerve head (ONH) is of primary importance in the pathogenesis of glaucoma. The potential to modify the blood flow in the ONH and its related structures has been reported in various agents, including topical antiglaucoma drugs and systemic drugs such as calcium channel antagonists, which are reviewed in this manuscript. Clinical implications of the improvement in ocular blood flow on the treatment of glaucomatous optic neuropathy require further investigation.
authors: Department of Ophthalmology, The University of Tokyo School of Medicine, Tokyo, Japan.
authors: Chihiro
authors: C
authors: Mayama
authors: Makoto
authors: M
authors: Araie
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001783:Blood Flow Velocity / Q000502:physiology; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use; D018679:Cholinergic Agonists / Q000627:therapeutic use; D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D009898:Optic Disk / Q000098:blood supply*; D009901:Optic Nerve Diseases / Q000503:physiopathology*; D011465:Prostaglandins, Synthetic / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects*
chemical_list: D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002257:Carbonic Anhydrase Inhibitors; D018679:Cholinergic Agonists; D011465:Prostaglandins, Synthetic