title: Relationship between endothelial dysfunction and nocturia with benign prostatic hyperplasia.
abstract: OBJECTIVE
  There are limited data on whether there is an association between nocturia, benign prostatic hyperplasia (BPH) and endothelial dysfunction. The aim of the present study was to evaluate whether there is an association between nocturia and endothelial dysfunction in patients with BPH.
  
  
  METHODS
  Forty-two men with a diagnosis of BPH and 42 age-matched controls were enrolled. All patients were assessed for frequency and duration of nocturia, and prostate volume, completed the International Prostate Symptom Score (IPSS) questionnaire, and underwent brachial flow-mediated dilatation (FMD) evaluation.
  
  
  RESULTS
  There was a negative correlation between FMD and frequency of nocturia (r = -0.879, p < 0.0001). Moreover, there was a negative correlation between duration of nocturia and FMD (r = -0.890, p < 0.0001). In addition, FMD was significantly decreased in the BPH group compared with the control group (6.0 ± 0.09 to 7.8 ± 0.10%) (p = 0.0001).
  
  
  CONCLUSIONS
  In patients with BPH, nocturia is associated with endothelial dysfunction and may be an insidious risk factor for cardiovascular disease.
authors: Department of Urology, Mustafa Kemal University School of Medicine, Hatay, Turkey.
authors: Mehmet
authors: M
authors: Inci
authors: Bahadir
authors: B
authors: Sarli
authors: Mursel
authors: M
authors: Davarci
authors: Fatih Rustu
authors: FR
authors: Yalcinkaya
authors: Murat Mehmet
authors: MM
authors: Rifaioğlu
authors: Ramazan
authors: R
authors: Davran
authors: Secil
authors: S
authors: Arica
authors: Sedat
authors: S
authors: Motor
authors: Onur
authors: O
authors: Demirbaş
mesh_terms: D000328:Adult; D000368:Aged; D001916:Brachial Artery / Q000503:physiopathology; D016022:Case-Control Studies; D015897:Comorbidity; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000453:epidemiology / Q000503:physiopathology*; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000453:epidemiology / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000502:physiology; D012307:Risk Factors