title: Synthesis of isocoumarin derivatives by copper-catalyzed addition of o-halobenzoic acids to active internal alkynes.
abstract: The addition of o-halobenzoic acids to active internal alkynes proceeds efficiently in the presence of CuCl(2) as a catalyst to give the corresponding isocoumarin derivatives in moderate to good yields. This strategy offers a simple, efficient route to synthesis of the isocoumarin derivatives.
authors: Shanghai Center for Systems Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China. xunxiang_guo@sjtu.edu.cn
authors: Xun-Xiang
authors: XX
authors: Guo
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001565:Benzoates; D006846:Hydrocarbons, Halogenated; D049934:Isocoumarins; D003300:Copper