title: Immunohistochemical analysis of inflammatory cells in benign and precancerous lesions and carcinoma of the prostate.
abstract: OBJECTIVE
  Inflammation is an important cause of tumorigenesis in various types of malignancy. Mediators derived from inflammatory cells are associated with cancer proliferation, angiogenesis, and DNA damage. In the present study, we immunohistochemically examined the infiltration patterns of inflammatory cells in benign glands including glandular hyperplasia, and in prostatic intraepithelial neoplasia and adenocarcinoma.
  
  
  METHODS
  Formalin-fixed, paraffin-embedded tissues were obtained from 100 patients with prostate cancer. All patients underwent radical prostatectomy. We assessed the number of infiltrating T cells (CD3(+)), B cells (CD20(+), CD79alpha(+)), and macrophages (CD68(+), CD204(+)) in benign and malignant prostate tumors.
  
  
  RESULTS
  CD68(+) macrophages infiltrated benign glands to a higher extent than those of adenocarcinoma. In contrast, the number of CD204(+) cells was higher in malignant glands than in benign glands. There was no significant difference in the number of infiltrating T cells between benign and malignant tumors; however, the number of infiltrating B cells was significantly reduced in malignant glands.
  
  
  CONCLUSIONS
  Inflammation of the prostate may act on prostate carcinomas; particularly that involving M2 macrophage infiltration may play a significant role in prostate carcinogenesis.
authors: Department of Pathology, Nara Medical University School of Medicine, Nara, Japan.
authors: Tomomi
authors: T
authors: Fujii
authors: Keiji
authors: K
authors: Shimada
authors: Osamu
authors: O
authors: Asai
authors: Nobumichi
authors: N
authors: Tanaka
authors: Kiyohide
authors: K
authors: Fujimoto
authors: Kazuya
authors: K
authors: Hirao
authors: Noboru
authors: N
authors: Konishi
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology*; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000276:immunology / Q000473:pathology; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology / Q000473:pathology*; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000276:immunology / Q000473:pathology*; D019048:Prostatic Intraepithelial Neoplasia / Q000276:immunology / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology