title: Mutant and wild-type Ras: co-conspirators in cancer.
abstract: Although the functional interplay between mutant and wild-type Ras in driving tumor initiation and growth has been described, a clear picture of the precise ramifications and mechanisms of this association remains elusive, sometimes with conflicting conclusions. A report in this issue of Cancer Discovery tackles this question, which may have important implications for therapeutic strategies to block mutant Ras for cancer treatment.
authors: Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
authors: Tikvah K
authors: TK
authors: Hayes
authors: Channing J
authors: CJ
authors: Der
mesh_terms: D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*
chemical_list: D020928:Mitogen-Activated Protein Kinases