title: Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains.
abstract: Six different adjuvants, each in combination with inactivated polio vaccine (IPV) produced with attenuated Sabin strains (sIPV), were evaluated for their ability to enhance virus neutralizing antibody titres (VNTs) in the rat potency model. The increase of VNTs was on average 3-, 15-, 24-fold with adjuvants after one immunization (serotypes 1, 2, and 3, respectively). Also after a boost immunization the VNTs of adjuvanted sIPV were on average another 7-20-27 times higher than after two inoculations of sIPV without adjuvant. The results indicate that it is feasible to increase the potency of inactivated polio vaccines by using adjuvants.
authors: Institute for Translational Vaccinology, Antonie van Leeuwenhoeklaan 9, 3720 AL Bilthoven, The Netherlands. janny.westdijk@rivm.nl
authors: Janny
authors: J
authors: Westdijk
authors: Patrick
authors: P
authors: Koedam
authors: Mario
authors: M
authors: Barro
authors: Benjamin P
authors: BP
authors: Steil
authors: Nicolas
authors: N
authors: Collin
authors: Thomas S
authors: TS
authors: Vedvick
authors: Wilfried A M
authors: WA
authors: Bakker
authors: Peter
authors: P
authors: van der Ley
authors: Gideon
authors: G
authors: Kersten
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D009500:Neutralization Tests; D017955:Poliovirus / Q000276:immunology*; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage / Q000276:immunology; D023321:Poliovirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D051381:Rats
chemical_list: D000276:Adjuvants, Immunologic; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated; D023321:Poliovirus Vaccines