title: Larch arabinogalactan effects on reducing incidence of upper respiratory infections.
abstract: OBJECTIVE
  Larch arabinogalactan (ResistAid * ) may prevent cold infections due to its immune-stimulatory properties. In a placebo-controlled, double-blind, randomized clinical trial, the effect of a proprietary larch arabinogalactan preparation on the incidences of common colds and its effect on cold symptoms, as a well established model for immune function, was compared to placebo.
  
  
  METHODS
  A total of 199 healthy participants who had a self reported cold infection rate of three in 6 months were randomly assigned to receive a total of either 4.5 g of an arabinogalactan preparation (n = 101) or placebo (n = 98) over a period of 12 weeks.
  
  
  METHODS
  The participants documented each common cold episode in a diary, and rated 10 predefined infection symptoms on a 4 point rating scale during an infection period, resulting in an infection score. The common cold episodes were confirmed by medical doctors.
  
  
  BACKGROUND
  ISRCTN41183655.
  
  
  RESULTS
  In the full analysis set (FAS), arabinogalactan tended to decrease the incidence of common cold (p = 0.055). The number of participants affected by a cold was significantly reduced by arabinogalactan supplementation (p = 0.038). Concerning the per protocol (PP) collective, the incidences of common cold (p = 0.040) and the number of participants affected by the infection (p = 0.033) were significantly fewer after arabinogalactan compared to placebo consumption. The severity of symptoms at episode start as experienced by the participants was significantly higher after arabinogalactan supplementation (p = 0.028). The treatment was well tolerated with no significant differences between the study groups.
  
  
  CONCLUSIONS
  The present study demonstrated that larch arabinogalactan increased the body's potential to defend against common cold infection. While the immunomodulatory effect of arabinogalactan can be assumed, its mechanism of action remains to be elucidated.
authors: Analyze & realize AG, Berlin, Germany. aa@a-r.com
authors: L
authors: L
authors: Riede
authors: B
authors: B
authors: Grube
authors: J
authors: J
authors: Gruenwald
mesh_terms: D000328:Adult; D000368:Aged; D003139:Common Cold / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005685:Galactans / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects*; D015994:Incidence; D028221:Larix / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010919:Placebos; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005685:Galactans; D010919:Placebos; D010936:Plant Extracts; C005653:arabinogalactan