title: Contrast dose, temporal footprint, and spatial resolution tradeoffs in dynamic contrast-enhanced MRA performed in a porcine model of a carotid aneurysm.
abstract: OBJECTIVE
  To evaluate the tradeoffs between temporal and spatial resolution and contrast dosing in dynamic contrast-enhanced magnetic resonance angiography (CE-MRA).
  
  
  METHODS
  Bilateral carotid artery aneurysms were created in a swine model. Dynamic CE-MRA using 1 mol/L gadobutrol was performed at 3 T, with high temporal (high-temp), middle temporal (mid-temp), and low temporal (low-temp) resolutions. High temporal CE-MRA was performed twice using 1 mL and 2 mL gadobutrol (2 mL/s). Middle temporal and low-temp sequences were performed once with 2 mL gadobutrol (2 mL/s). The signal-to-noise ratio (SNR) was quantitatively assessed. Blinded reads were used to qualitatively evaluate contrast dose and image quality.
  
  
  RESULTS
  The mean SNRs of high-temp, mid-temp, and low-temp resolutions were 56.7, 47.5, and 48.1. There was no significant difference between the 3 sequences with 2 mL gadobutrol. The mean SNR of the high-temp resolution with 2 mL was significantly higher than that with 1 mL (56.7 vs 39.9). In qualitative analysis, the 3 temporal sequences with 2 mL gadobutrol showed no significant differences regarding overall image quality and diagnostic value. High temporal resolution with 2 mL consistently showed the superiority of image quality than that with 1 mL.
  
  
  CONCLUSIONS
  High temporal dynamic CE-MRA with 2 mL (0.04 mmol/kg body weight) gadobutrol can produce consistently superior image quality over that with 1 mL (0.02 mmol/kg body weight). For a given contrast dose, the tradeoffs between temporal and spatial resolution will not result in significant differences in image quality in TWIST (time-resolved angiography with interleaved stochastic trajectories).
authors: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors: Tao
authors: T
authors: Ai
authors: Frank
authors: F
authors: Goerner
authors: Nirav
authors: N
authors: Patel
authors: Miguel
authors: M
authors: Trelles
authors: Gang
authors: G
authors: Wu
authors: Xiaoming
authors: X
authors: Li
authors: Val M
authors: VM
authors: Runge
mesh_terms: D000783:Aneurysm / Q000175:diagnosis*; D000818:Animals; D002340:Carotid Artery Diseases / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage; D004195:Disease Models, Animal; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography / Q000379:methods*; D009942:Organometallic Compounds; D059629:Signal-To-Noise Ratio; D013552:Swine
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol