title: Hemodynamic effects of dexmedetomidine--fentanyl vs. nalbuphine--propofol in plastic surgery.
abstract: Dexmedetomidine has demonstrated to be useful in several clinical fields due to its respiratory safety and cardiovascular stability. We undertook this study to determine its usefulness in plastic surgery. Sixty patients were divided into two parallel groups. A group received dexmedetomidine--fentanyl and the comparison group received nalbuphine--propofol, both with same dose of midazolam. Blood pressure, heart rate and oxygen saturation were determined during the preoperative, intraoperative and recuperation periods.
  
  
  RESULTS
  In both groups, hemodynamic constants decreased intraoperatively. Dexmedetomidine--fentanyl decreased more than in the nalbuphine--propofol (systolic blood pressure, p = 0.006; diastolic blood pressure, p = 0.01 and heart rate, p = 0.007). Comparatively, oxygen saturation was greater in the dexmedetomidine--fentanyl group vs. nalbuphine--propofol (p = 0.0001). Recovery time for the nalbuphine--propofol group was shorter than in the dexmedetomidine--fentanyl group (p = 0.0001).
  
  
  CONCLUSIONS
  Dexmedetomidine shows the same cardiovascular stability but with absence of respiratory depression.
authors: Department of Anesthesiology, Institute of Reconstructive Surgery of Jalisco, Health Secretary, Guadalajara, México.
authors: Juan F
authors: JF
authors: De La Mora-González
authors: José A
authors: JA
authors: Robles-Cervantes
authors: José M
authors: JM
authors: Mora-Martínez
authors: Francisco
authors: F
authors: Barba-Alvarez
authors: Emigdio De La Cruz
authors: Ede L
authors: Llontop-Pisfil
authors: Manuel
authors: M
authors: González-Ortiz
authors: Esperanza
authors: E
authors: Martínez-Abundis
authors: Juan F
authors: JF
authors: Llamas-Moreno
authors: María Claudia
authors: MC
authors: Espinel Bermúdez
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects; D020927:Dexmedetomidine / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects; D008874:Midazolam / Q000008:administration & dosage; D008875:Middle Aged; D009266:Nalbuphine / Q000008:administration & dosage* / Q000009:adverse effects; D010100:Oxygen / Q000378:metabolism; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D019651:Plastic Surgery Procedures / Q000379:methods; D012131:Respiratory Insufficiency / Q000139:chemically induced
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D009266:Nalbuphine; D008874:Midazolam; D010100:Oxygen; D005283:Fentanyl; D015742:Propofol