title: Manipulating Reduction Potentials in an Artificial Safranin Cofactor.
abstract: Safranines hold great promise as artificial flavin-like electron transfer cofactors with tunable properties. We report the design and chemical synthesis of the p-methoxy derivative of safranine O using a new synthetic route based on the Ulmann condensation. Spectroelectrochemical comparison of the purified parent safranine and this derivative demonstrates that the modification increases its two-electron reduction potential by 125 mV, or 5.75 kcal/mol. This modification also causes redshifts in the absorbance and fluorescence spectra of the cofactor, suggesting that it may find future utility in arrayed sensor applications.
authors: Department of Chemistry, The City College of New York, New York, NY 10031.
authors: Gheevarghese
authors: G
authors: Raju
authors: Joseph
authors: J
authors: Capo
authors: Bruce R
authors: BR
authors: Lichtenstein
authors: Jose F
authors: JF
authors: Cerda
authors: Ronald L
authors: RL
authors: Koder