title: Comparison of the effects of human adipose and bone marrow mesenchymal stem cells on T lymphocytes.
abstract: Mesenchymal stem cells (MSCs) are multipotent cells that can be derived either from the bone marrow (bMSCs) or adipose tissue (aMSCs). We have compared the immune regulatory properties of cells derived from bone marrow and adipose tissue to provide a theoretical basis for the choice of stem cell source for transplantation. The phenotypes of bMSCs and aMSCs are similar, differing only in the expression of CD106. aMSCs proliferate faster than bMSCs, but aMSCs suppressed T-lymphocyte proliferation and activation more poorly than bMSCs. Thus cell origin and abundance are important factors in determining the suitability of MSCs for transplantation. Adipose tissue offers a more promising source of cells for such an application.
authors: Institute of Medical Oncology, Beijing Shijitan Hospital, Capitial Medical University, Beijing 100038, PR China.
authors: Zhu
authors: Z
authors: Xishan
authors: He
authors: H
authors: Baoxin
authors: Zhou
authors: Z
authors: Xinna
authors: Ren
authors: R
authors: Jun
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism*; D001854:Bone Marrow Cells / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism