title: Labdane-type diterpenoids from the fruits of Vitex trifolia.
abstract: Seven new labdane-type diterpenoids, vitextrifolins A-G (1-7), along with eight previously reported analogues, were isolated from the fruits of Vitex trifolia. The structures of 1-7 were elucidated by spectroscopic data interpretation. The isolates were evaluated for their cytotoxicity against four human cancer cell lines (A549, HCT116, HL-60, and ZR-75-30), but all were inactive (IC(50) < 5 μg/mL).
authors: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors: Cheng-Jian
authors: CJ
authors: Zheng
authors: Jian-Yong
authors: JY
authors: Zhu
authors: Wu
authors: W
authors: Yu
authors: Xue-Qin
authors: XQ
authors: Ma
authors: Khalid
authors: K
authors: Rahman
authors: Lu-Ping
authors: LP
authors: Qin
mesh_terms: D000465:Algorithms; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D045325:HCT116 Cells; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D020950:Vitex / Q000737:chemistry*
chemical_list: D004224:Diterpenes; C433017:labdane