title: Non-autophagic roles of autophagy-related proteins.
abstract: Autophagy and autophagy-related processes are fundamentally important in human health and disease. These processes are viewed primarily as cellular degradative pathways that recycle macromolecules and dysfunctional or redundant organelles into amino acids, sugars and lipids, especially during starvation. However, the ubiquitin-like autophagy proteins and other components of the autophagic machinery additionally participate in cellular reprogramming. We highlight these non-autophagic roles of autophagy proteins with the aim of drawing attention to this growing, but unexplored, research topic. We focus on the non-autophagic functions of autophagy proteins in cell survival and apoptosis, modulation of cellular traffic, protein secretion, cell signalling, transcription, translation and membrane reorganization.
authors: Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, California 92093-0322, USA. ssubramani@ucsd.edu
authors: Suresh
authors: S
authors: Subramani
authors: Vivek
authors: V
authors: Malhotra
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D050156:Adipogenesis; D000818:Animals; D001343:Autophagy; D000071192:Autophagy-Related Protein 12; D000071187:Autophagy-Related Protein 5; D000071193:Autophagy-Related Protein 7; D000071190:Autophagy-Related Protein 8 Family; D005089:Exocytosis; D054884:Host-Pathogen Interactions; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D008840:Microfilament Proteins / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000502:physiology; D021381:Protein Transport; D015398:Signal Transduction; D025841:Small Ubiquitin-Related Modifier Proteins / Q000502:physiology; D044764:Ubiquitin-Activating Enzymes / Q000502:physiology
chemical_list: C466624:ATG12 protein, human; C502778:ATG5 protein, human; D048868:Adaptor Proteins, Signal Transducing; D000071192:Autophagy-Related Protein 12; D000071187:Autophagy-Related Protein 5; D000071190:Autophagy-Related Protein 8 Family; C498698:GABARAPL2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008840:Microfilament Proteins; D008869:Microtubule-Associated Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; C509349:ATG7 protein, human; D000071193:Autophagy-Related Protein 7; D044764:Ubiquitin-Activating Enzymes