title: Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.
abstract: Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.
authors: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
authors: Juliann
authors: J
authors: Chmielecki
authors: Aimee M
authors: AM
authors: Crago
authors: Mara
authors: M
authors: Rosenberg
authors: Rachael
authors: R
authors: O'Connor
authors: Sarah R
authors: SR
authors: Walker
authors: Lauren
authors: L
authors: Ambrogio
authors: Daniel
authors: D
authors: Auclair
authors: Aaron
authors: A
authors: McKenna
authors: Michael C
authors: MC
authors: Heinrich
authors: David A
authors: DA
authors: Frank
authors: Matthew
authors: M
authors: Meyerson
mesh_terms: D001483:Base Sequence; D059472:Exome / Q000235:genetics*; D040461:Gene Components; D050939:Gene Fusion / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D050800:STAT6 Transcription Factor / Q000235:genetics*; D017422:Sequence Analysis, DNA; D054364:Solitary Fibrous Tumors / Q000235:genetics*
chemical_list: C099945:Nab2 protein, mouse; D009363:Neoplasm Proteins; D012097:Repressor Proteins; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human