title: The NOFLO trial: low-flow nasal prongs therapy in weaning nasal continuous positive airway pressure in preterm infants.
abstract: OBJECTIVE
  To determine if low-flow nasal prongs therapy with room air, compared with no treatment, facilitates weaning from nasal continuous positive airway pressure (NCPAP) in very low birth weight (VLBW, birth weight <1500 g) infants.
  
  
  METHODS
  VLBW infants who received respiratory support for ≥ 48 hours and who were stable on NCPAP for 24 hours were eligible for inclusion in this multicenter, randomized controlled trial. On stopping NCPAP, infants were randomized to receive 1 L/min air via nasal prongs or to spontaneous breathing in room air. The primary outcome measure was failure to wean. Secondary outcome measures included length of time to failure and change in heart rate, respiratory rate, oxygen saturation, and respiratory distress score.
  
  
  RESULTS
  Seventy-eight infants were randomized: 39 to nasal prongs and 39 to spontaneous breathing. The groups were similar at birth and at randomization. Sixteen infants (41%) in the nasal prongs group failed the weaning process compared with 12 infants (31%) in the spontaneous breathing group (OR 1.57, 95% CI 0.56 to 4.43, P = .48). There were no significant differences between the groups in secondary outcomes.
  
  
  CONCLUSIONS
  In this study, we did not demonstrate a benefit of low-flow room air via nasal prongs to wean VLBW infants from NCPAP.
authors: Coombe Women and Infants University Hospital, Dublin, Ireland.
authors: Sinéad M
authors: SM
authors: O'Donnell
authors: Sarah J
authors: SJ
authors: Curry
authors: Niamh A
authors: NA
authors: Buggy
authors: Margaret M
authors: MM
authors: Moynihan
authors: Sylva
authors: S
authors: Sebkova
authors: Jan
authors: J
authors: Janota
authors: Jan
authors: J
authors: Miletin
mesh_terms: D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D015300:Ventilator Weaning / Q000295:instrumentation