title: Solphenazines A-F, glycosylated phenazines from Streptomyces sp. strain DL-93.
abstract: During a survey of actinobacteria known to suppress the growth of Streptomyces scabies (the causative agent of potato scab disease) in vivo, six new rhamnosylated alkaloids, the solphenazines A-F (1-6), were isolated from a biological control strain of Streptomyces (DL-93). The known rhamnosyl analogue of paraben (9) was also isolated along with a new rhamnosylated derivative of N-methyl-p-aminobenzoic acid (10). None of the compounds exhibited any antibacterial or antifungal activity against a standard panel of microorganisms, but compounds 1, 2, and 6 displayed some cytotoxicity against HCT-116 cancer cells. Additional in vitro testing provided data suggesting that the cytotoxic activity is not due to DNA intercalation or topoisomerase inhibition.
authors: Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors: Yudi
authors: Y
authors: Rusman
authors: Lisa M
authors: LM
authors: Oppegard
authors: Hiroshi
authors: H
authors: Hiasa
authors: Christopher
authors: C
authors: Gelbmann
authors: Christine E
authors: CE
authors: Salomon
mesh_terms: D010129:4-Aminobenzoic Acid / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045325:HCT116 Cells; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010935:Plant Diseases / Q000382:microbiology*; D013302:Streptomyces / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000254:growth & development
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D010619:Phenazines; D010129:4-Aminobenzoic Acid