title: Rapid detection and quantitation of ketamine and norketamine in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry.
abstract: Drug analysis is an indispensable task in controlling drug abuse, which is a serious problem worldwide nowadays. In this study, we report a simple and rapid approach for detection and quantitation of drugs-of-abuse in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS). We demonstrated that ketamine, one of the most common abused drugs, and its major metabolite, norketamine, in raw urine and oral fluid could be readily detected and quantified by WT-ESI-MS with only little sample preparation and no chromatographic separation, and the analytical performances, including the linear range, accuracy, precision, LOD and LOQ, were well acceptable for analysis of real samples.
authors: State Key Laboratory of Chirosciences, Food Safety and Technology Research Centre and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region, China.
authors: Pui-Kin
authors: PK
authors: So
authors: Tsz-Tsun
authors: TT
authors: Ng
authors: Haixing
authors: H
authors: Wang
authors: Bin
authors: B
authors: Hu
authors: Zhong-Ping
authors: ZP
authors: Yao
mesh_terms: D006801:Humans; D013287:Illicit Drugs / Q000652:urine*; D007649:Ketamine / Q000031:analogs & derivatives* / Q000652:urine*; D012463:Saliva / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D015813:Substance Abuse Detection / Q000379:methods*; D019966:Substance-Related Disorders / Q000175:diagnosis
chemical_list: D013287:Illicit Drugs; D007649:Ketamine; C033419:norketamine