title: Relationship between maternal thyroid hormones and the biochemical markers of the first trimester aneuploidy screening.
abstract: OBJECTIVE
  The role of thyroid function in biochemical markers of first trimester screening has not been assessed. The aim of the present study was to investigate if there were any relation between maternal thyroid hormones and free-beta subunit of human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma protein A (PAPP-A) levels as the biochemical markers of the combined first trimester aneuploidy screening.
  
  
  METHODS
  375 pregnant women between 11 and 14 weeks of gestation who were offered routine first trimester prenatal aneuploidy screening and whose thyroid hormone levels (Thyroid stimulating hormone (TSH), free and total thyroxine, free and total triiodothyronine, anti thyroid peroxidase antibody) were measured were assessed. Correlation of free-β-hCG and PAPP-A with maternal thyroid hormones was analyzed.
  
  
  RESULTS
  There was no statistically significant correlation between maternal TSH, free and total thyroxine, free and total triiodothyronine, anti-thyroid peroxidase antibodies and free-β-hCG and PAPP-A as biochemical markers of first trimester aneuploidy screening.
  
  
  CONCLUSIONS
  Maternal thyroid function does not seem to affect secretion of fβ-hCG and PAPP-A.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey. drhakanaytan@yahoo.com
authors: Hakan
authors: H
authors: Aytan
authors: Ahmet C
authors: AC
authors: Caliskan
authors: Fazlı
authors: F
authors: Demirturk
authors: Semsettin
authors: S
authors: Sahin
authors: Filiz
authors: F
authors: Erdogan
authors: Zehra
authors: Z
authors: Kuzu
mesh_terms: D000328:Adult; D000782:Aneuploidy; D015415:Biomarkers / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D004314:Down Syndrome / Q000175:diagnosis; D005260:Female; D005865:Gestational Age; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis; D007037:Hypothyroidism / Q000175:diagnosis; D008423:Maternal Age; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D013963:Thyroid Hormones; D013972:Thyrotropin; D011266:Pregnancy-Associated Plasma Protein-A; D013974:Thyroxine