title: Sex differences of oxidative stress markers in young healthy subjects are marker-specific in plasma but not in saliva.
abstract: BACKGROUND
  Several studies showed there are sex differences in oxidative stress. An observational study analysing oxidative stress markers in young healthy men and women is lacking. Moreover, it is unclear whether the differences are related to sex hormones.
  
  
  OBJECTIVE
  The primary goal was to analyse differences in oxidative stress markers with regard to sex in plasma of young healthy subjects and whether differences are related to sex hormones. The secondary study compared oxidative stress markers in plasma with salivary samples.
  
  
  METHODS
  Plasma and saliva samples were analysed from 158 young healthy probands. Established spectro-photometric/fluorometric methods were used to quantify oxidative stress markers. Sex hormones were measured using ELISA kits.
  
  
  RESULTS
  In plasma, malondialdehyde and advanced glycation end products were significantly higher in women. Advanced oxidation protein products and the ferric reducing ability of plasma were higher in men. Sex hormones were not associated with oxidative stress markers. In saliva, analysed markers of antioxidant status were higher in men, but no sex differences were found in other markers.
  
  
  CONCLUSIONS
  Observed parameters showed marker-specific sex differences in plasma, but these differences were not related to sex hormones. Plasma and saliva concentrations of biomarkers did not correlate, reflecting oral but not systemic conditions.
authors: Institute of Molecular Biomedicine, Faculty of Medicine in Bratislava, Comenius University, 811 08 Bratislava, Slovakia.
authors: L'ubomíra
authors: L
authors: Tóthová
authors: Daniela
authors: D
authors: Ostatníková
authors: Katarína
authors: K
authors: Šebeková
authors: Peter
authors: P
authors: Celec
authors: Július
authors: J
authors: Hodosy
mesh_terms: D062107:Advanced Oxidation Protein Products / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017127:Glycation End Products, Advanced / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D012463:Saliva / Q000737:chemistry; D012727:Sex Characteristics; D017678:Sex Distribution; D018154:Slovakia; D013050:Spectrometry, Fluorescence; D055815:Young Adult
chemical_list: D062107:Advanced Oxidation Protein Products; D000975:Antioxidants; D015415:Biomarkers; D017127:Glycation End Products, Advanced; D012739:Gonadal Steroid Hormones; D008315:Malondialdehyde