title: More than two decades of Apc modeling in rodents.
abstract: Mutation of tumor suppressor gene adenomatous polyposis coli (APC) is an initiating step in most colon cancers. This review summarizes Apc models in mice and rats, with particular concentration on those most recently developed, phenotypic variation among different models, and genotype/phenotype correlations.
authors: Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Ave., Lawrence, KS 66045, USA.
authors: Maged
authors: M
authors: Zeineldin
authors: Kristi L
authors: KL
authors: Neufeld
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000209:etiology* / Q000473:pathology; D025601:Adenomatous Polyposis Coli Protein / Q000502:physiology*; D000818:Animals; D004195:Disease Models, Animal; D005838:Genotype; D006801:Humans; D051379:Mice; D010641:Phenotype; D051381:Rats
chemical_list: D025601:Adenomatous Polyposis Coli Protein