title: Ontogenetic influence on rat susceptibility to lindane seizure after pretreatment with phencyclidine.
abstract: The aim of the study was to determine the effects of early postnatal PCP treatment on the sensitivity of pubertal and adult rats to lindane proepileptogenic effects. Rat pups were treated with NaCl (0.9%) or PCP (10 mg/kg) at postnatal days 2, 6, 9 and 12. One control (NaCl-35) and one experimental (PCP-35) group have received lindane (4 mg/kg) at postnatal day 35, while others received lindane at postnatal day 65 (NaCl-65 and PCP-65). One week prior to lindane treatment three gold-plated EEG electrodes were implanted. Pubertal rats had significantly shorter latency time. After lindane, a prompt increase in power spectral density seen in PCP-treated groups vs. control was evident earlier in PCP-65 rats. The theta waves were significantly increased in PCP-35 and alpha rhythm in PCP-65 rats, when compared with corresponding controls. Postnatal PCP treatment increases the synchronization of brain electrical activity, thus contributing to the increased susceptibility to lindane.
authors: Laboratory of Neurophysiology, Institute of Medical Physiology Richard Burian, Faculty of Medicine, University of Belgrade, Višegradska 26/II, 11000 Belgrade, Serbia. solja@afrodita.rcub.bg.ac.rs
authors: Olivera
authors: O
authors: Stanojlović
authors: Tatjana
authors: T
authors: Nikolić
authors: Dragan
authors: D
authors: Hrnčić
authors: Nevena
authors: N
authors: Radonjić
authors: Aleksandra
authors: A
authors: Rašić-Marković
authors: Dušan
authors: D
authors: Mladenović
authors: Nataša
authors: N
authors: Petronijević
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D004198:Disease Susceptibility; D004569:Electroencephalography; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D010622:Phencyclidine / Q000494:pharmacology*; D011627:Puberty; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced*
chemical_list: D001556:Hexachlorocyclohexane; D010622:Phencyclidine