title: Major influence of renal function on hyperlipidemia after living donor liver transplantation.
abstract: OBJECTIVE
  To investigate the impact of renal and graft function on post-transplant hyperlipidemia (PTHL) in living donor liver transplantation (LDLT).
  
  
  METHODS
  A total of 115 adult patients undergoing LDLT from January 2007 to May 2009 at a single center were enrolled. Data were collected and analyzed by the China Liver Transplant Registry retrospectively. PTHL was defined as serum triglycerides ≥ 150 mg/dL or serum cholesterol ≥ 200 mg/dL or the need for pharmacologic treatment at the sixth month after LDLT. Early renal dysfunction (ERD) was defined as serum creatinine ≥ 2 mg/dL and/or the need for renal replacement therapy in the first post-transplant week.
  
  
  RESULTS
  In 115 eligible patients, the incidence of PTHL was 24.3%. Recipients with PTHL showed a higher incidence of post-transplant cardiovascular events compared to those without PTHL (17.9% vs 4.6%, P = 0.037). Serum creatinine showed significant positive correlations with total serum triglycerides, both at post-transplant month 1 and 3 (P < 0.01). Patients with ERD had much higher pre-transplant serum creatinine levels (P < 0.001) and longer duration of pre-transplant renal insufficiency (P < 0.001) than those without ERD. Pre-transplant serum creatinine, graft-to-recipient weight ratio, graft volume/standard liver volume ratio, body mass index (BMI) and ERD were identified as risk factors for PTHL by univariate analysis. Furthermore, ERD [odds ratio (OR) = 9.593, P < 0.001] and BMI (OR = 6.358, P = 0.002) were identified as independent risk factors for PTHL by multivariate analysis.
  
  
  CONCLUSIONS
  Renal function is closely associated with the development of PTHL in LDLT. Post-transplant renal dysfunction, which mainly results from pre-transplant renal insufficiency, contributes to PTHL.
authors: Key Lab of Combined Multi-Organ Transplantation, Key Lab of Organ Transplantation, Ministry of Public Health, Hangzhou 310003, Zhejiang Province, China.
authors: Qi
authors: Q
authors: Ling
authors: Kai
authors: K
authors: Wang
authors: Di
authors: D
authors: Lu
authors: Hai-Jun
authors: HJ
authors: Guo
authors: Wen-Shi
authors: WS
authors: Jiang
authors: Xiang-Xiang
authors: XX
authors: He
authors: Xiao
authors: X
authors: Xu
authors: Shu-Sen
authors: SS
authors: Zheng
mesh_terms: D000293:Adolescent; D000328:Adult; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications* / Q000378:metabolism; D015994:Incidence; D007668:Kidney / Q000503:physiopathology*; D017093:Liver Failure / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D003404:Creatinine
keywords: Graft function; Hyperlipidemia; Liver transplantation; Prognosis; Renal insufficiency; Risk factors