title: Preoperative histological grading of meningiomas using apparent diffusion coefficient at 3T MRI.
abstract: OBJECTIVE
  We assessed whether a high b-value DWI at b=4000s/mm(2) would discriminate the histopathological differentiation of the tumor grade of meningiomas, and also focused on the relationship between radiologic features and the tumor grade.
  
  
  METHODS
  We acquired DWI at 3T with b=1000 and b=4000s/mm(2) in 77 patients (42, 31 and 4 patients were WHO grades I (G1), II (G2), and III (G3), respectively). The apparent diffusion coefficient (ADC) was measured by placing multiple regions of interest (ROIs) on ADC maps. The ADC values of each tumor were determined preoperatively from several ROIs, and expressed as the minimum (ADCMIN), mean (ADCMEAN), and maximum absolute values (ADCMAX). We evaluated the relationship between ADCs and histological findings, and assessed the radiologic features such as tumor location, tumor size, presence/absence of peritumoral edema, shape of the tumor, presence/absence of bone destruction or hyperplasia, status of contrast enhancement, presence/absence of calcification and cyst.
  
  
  RESULTS
  ADCs of the meningiomas were inversely correlated with the histological grade of meningiomas. According to results of the discriminant analysis, the apparent log likelihood value was greatest for ADCMIN at b=4000. Furthermore, only the ADCMIN value at b=4000 was significantly correlated with the histological grade of meningiomas when we performed a multiple logistic regression analysis to identify the significant independent factors such as shape of tumor, presence/absence of bone destruction, status of contrast enhancement, presence/absence of cyst and ADCMIN at b=4000.
  
  
  CONCLUSIONS
  A meningioma with a low ADCMIN at a high b-value might imply a high-grade meningioma.
authors: Department of Neurosurgery, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan. yowatanabe@hiroshima-u.ac.jp
authors: Yosuke
authors: Y
authors: Watanabe
authors: Fumiyuki
authors: F
authors: Yamasaki
authors: Yoshinori
authors: Y
authors: Kajiwara
authors: Takeshi
authors: T
authors: Takayasu
authors: Ryo
authors: R
authors: Nosaka
authors: Yuji
authors: Y
authors: Akiyama
authors: Kazuhiko
authors: K
authors: Sugiyama
authors: Kaoru
authors: K
authors: Kurisu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D008875:Middle Aged; D060787:Neoplasm Grading; D057234:Preoperative Period; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media