title: Toxicity assessment of anaerobic digestion intermediates and antibiotics in pharmaceutical wastewater by luminescent bacterium.
abstract: In order to evaluate the effect of anaerobic digestion intermediates and antibiotics in pharmaceutical wastewaters on anaerobic digestion process, their acute toxicities were tested using the 15 min median inhibitory concentration (IC(50)) at pH 7.00 ± 0.05. The results showed that the IC(50) of ethanol, acetate, propionate and butyrate were 19.40, 20.71, 10.47 and 12.17 g L(-1) respectively, which suggested the toxicity descended in the order of propionate, butyrate, ethanol and acetate. The IC(50) of aureomycin, polymyxin and chloromycetin were 12.06, 6.24 and 429.90 mg L(-1) respectively, which indicated the toxicity descended in the order of polymyxin, aureomycin and chloromycetin. Using equitoxic ratio mixing method, the joint toxicities of five groups referred by A (four anaerobic digestion intermediates), B (four anaerobic digestion intermediates and aureomycin), C (four anaerobic digestion intermediates and polymyxin), D (four anaerobic digestion intermediates and chloromycetin) and E (four anaerobic digestion intermediates, aureomycin, polymyxin and chloromycetin) were investigated respectively. Their interactions were additive (A), synergistic (B), additive (C), synergistic (D) and synergistic (E). The investigation would lay a basis for the optimization of anaerobic biotechnology for pharmaceutical wastewater treatment.
authors: Department of Environmental Engineering, Zhejiang University, Hangzhou 310058, China.
authors: Jun-Yuan
authors: JY
authors: Ji
authors: Ya-Juan
authors: YJ
authors: Xing
authors: Zi-Tao
authors: ZT
authors: Ma
authors: Jing
authors: J
authors: Cai
authors: Ping
authors: P
authors: Zheng
authors: Hui-Feng
authors: HF
authors: Lu
mesh_terms: D048908:Aliivibrio fischeri; D000693:Anaerobiosis; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D019149:Bioreactors; D004345:Drug Industry; D007220:Industrial Waste; D008163:Luminescent Measurements; D023382:Toxicity Tests, Acute; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000900:Anti-Bacterial Agents; D007220:Industrial Waste; D014874:Water Pollutants, Chemical