title: Bifunctional gene cluster lnqBCDEF mediates bacteriocin production and immunity with differential genetic requirements.
abstract: A comprehensive gene disruption of lacticin Q biosynthetic cluster lnqQBCDEF was carried out. The results demonstrated the necessity of the complete set of lnqQBCDEF for lacticin Q production, whereas immunity was flexible, with LnqEF (ABC transporter) being essential for and LnqBCD partially contributing to immunity.
authors: Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
authors: Shun
authors: S
authors: Iwatani
authors: Yuko
authors: Y
authors: Horikiri
authors: Takeshi
authors: T
authors: Zendo
authors: Jiro
authors: J
authors: Nakayama
authors: Kenji
authors: K
authors: Sonomoto
mesh_terms: D001430:Bacteriocins / Q000096:biosynthesis* / Q000494:pharmacology*; D053898:Biosynthetic Pathways / Q000235:genetics; D024881:Drug Resistance, Bacterial; D055786:Gene Knockout Techniques; D013294:Lactococcus lactis / Q000235:genetics* / Q000378:metabolism*; D005810:Multigene Family
chemical_list: D001430:Bacteriocins; C548356:lacticin Q, Lactococcus lactis