title: The incidence and mortality of thromboembolic events in lumbar spine surgery.
abstract: METHODS
  Retrospective database analysis.
  
  
  OBJECTIVE
  A population-based database was analyzed to identify the incidence, risk factors, and mortality associated with thromboembolic events after lumbar spine surgery.
  
  
  BACKGROUND
  Pulmonary embolism (PE) and deep vein thrombosis (DVT) are potential complications that may occur after orthopedic procedures. The incidence of these complications is not well characterized after lumbar spine surgery.
  
  
  METHODS
  Data from the Nationwide Inpatient Sample was obtained from 2002-2009. Patients undergoing lumbar decompression (LD), or lumbar fusion (LF) for degenerative conditions were identified. Acute PE and DVT incidences and mortality rates were calculated. Comorbidities were calculated using a modified Charlson Comorbidity Index. Statistical analysis was performed using the Student t test for discrete variables and χ test for categorical data. Logistic regression was used to identify independent predictors of thromboembolic events. A P value of less than or equal to 0.0005 was used to denote statistical significance.
  
  
  RESULTS
  A total 578,457 LDs and LFs were identified from 2002-2009. DVT incidences were 2.4 and 4.3 per 1000 cases in the LD and LF groups, respectively. PE incidences were 1.0 and 2.6 per 1000 cases in the LD and LF groups, respectively. Patients who had undergone LF with thromboembolic events were younger, had fewer comorbidities, and incurred greater costs than patients who had undergone LD. Statistically significant predictors of DVT were pulmonary circulation disorders, coagulopathy, fluid/electrolyte disorders, anemia, obesity, teaching hospital status, and larger hospitals. Predictors for the development of PE were pulmonary circulation disorders, fluid/electrolyte disorders, anemia, black ethnicity and teaching hospital status.
  
  
  CONCLUSIONS
  Patients undergoing LD or LF are at inherent risk of thromboembolic events. DVT and PE are more common after LF procedures. Preoperative pulmonary circulation disorders, fluid/electrolyte disorders, deficiency anemia, and teaching hospital status were significant risk factors for developing both DVT and PE. Preventive measures in patients at risk may decrease the incidence of thromboembolic events.
  
  
  METHODS
  4.
authors: Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
authors: Steven J
authors: SJ
authors: Fineberg
authors: Matthew
authors: M
authors: Oglesby
authors: Alpesh A
authors: AA
authors: Patel
authors: Miguel A
authors: MA
authors: Pelton
authors: Kern
authors: K
authors: Singh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D019299:Decompression, Surgical / Q000009:adverse effects*; D017721:Hospital Costs / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007297:Inpatients / Q000706:statistics & numerical data; D016015:Logistic Models; D008159:Lumbar Vertebrae / Q000601:surgery*; D008875:Middle Aged; D019637:Orthopedic Procedures; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D013123:Spinal Fusion / Q000009:adverse effects*; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D055815:Young Adult