title: T1 mapping for detection of left ventricular myocardial fibrosis in hypertrophic cardiomyopathy: a preliminary study.
abstract: OBJECTIVE
  To investigate the diagnostic value of T1 mapping imaging of evaluating fibrosis in patients with hypertrophic cardiomyopathy (HCM).
  
  
  METHODS
  21 subjects with HCM and 18 healthy volunteers underwent conventional late gadolinium enhancement (LGE) imaging and T1 mapping imaging. The region of myocardium in HCM is divided into remote area of LGE, peri-LGE, LGE (halo-like LGE and typical patchy LGE). These regions combined with normal volunteers' myocardium were calculated by the reduced percent of T1 value (RPTV).
  
  
  RESULTS
  The RPTV in healthy volunteers was no significant comparing with that in the remote area of LGE in HCM subjects (3.98 ± 3.19 vs. 3.34 ± 2.75, P>0.05). There were significant statistical differences in pairwise among the remote area of LGE, peri-LGE, halo-like LGE and typical patchy LGE in the RPTV (P<0.0001). ROC curves indicated that the T1 mapping imaging has a greater area under the curve comparing with that of traditional LGE imaging (0.975 ± 0.07 vs. 0.753 ± 0.26, P<0.0001).
  
  
  CONCLUSIONS
  HCM has a high prevalence of fibrosis and with varying severity. T1 mapping imaging can be a useful method to evaluate the severity of the fibrosis in HCM.
authors: Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Minjie
authors: M
authors: Lu
authors: Shihua
authors: S
authors: Zhao
authors: Gang
authors: G
authors: Yin
authors: Shiliang
authors: S
authors: Jiang
authors: Tao
authors: T
authors: Zhao
authors: Xiuyu
authors: X
authors: Chen
authors: Liangxin
authors: L
authors: Tian
authors: Yan
authors: Y
authors: Zhang
authors: Yunqing
authors: Y
authors: Wei
authors: Qiong
authors: Q
authors: Liu
authors: Zuoxiang
authors: Z
authors: He
authors: Hui
authors: H
authors: Xue
authors: Jing
authors: J
authors: An
authors: Saurabh
authors: S
authors: Shah
mesh_terms: D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000473:pathology*; D004719:Endomyocardial Fibrosis / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity