title: Illustrations of mathematical modeling in biology: epigenetics, meiosis, and an outlook.
abstract: In the past few years, mathematical modeling approaches in biology have begun to fulfill their promise by assisting in the dissection of complex biological systems. Here, we review two recent examples of predictive mathematical modeling in plant biology. The first involves the quantitative epigenetic silencing of the floral repressor gene FLC in Arabidopsis, mediated by a Polycomb-based system. The second involves the spatiotemporal dynamics of telomere bouquet formation in wheat-rye meiosis. Although both the biology and the modeling framework of the two systems are different, both exemplify how mathematical modeling can help to accelerate discovery of the underlying mechanisms in complex biological systems. In both cases, the models that developed were relatively minimal, including only essential features, but both nevertheless yielded fundamental insights. We also briefly review the current state of mathematical modeling in biology, difficulties inherent in its application, and its potential future development.
authors: Division of Molecular Biosciences, Imperial College London, SW7 2AZ, United Kingdom.
authors: D
authors: D
authors: Richards
authors: S
authors: S
authors: Berry
authors: M
authors: M
authors: Howard
mesh_terms: D044127:Epigenesis, Genetic; D035264:Flowers / Q000235:genetics / Q000502:physiology; D008540:Meiosis / Q000235:genetics*; D008954:Models, Biological; D010944:Plants / Q000235:genetics*; D016615:Telomere / Q000378:metabolism