title: LAPTM4B gene polymorphism and endometrial carcinoma risk and prognosis.
abstract: A novel gene called LAPTM4B (lysosome-associated protein transmembrane 4 beta) plays several crucial roles in carcinogenesis. In this case-control study, we investigated the relationship between LAPTM4B gene polymorphism and susceptibility to endometrial carcinoma (EC). In an adjusted multivariate logistic regression analyses, subjects with the LAPTM4B*1/2 and *2/2 genotypes respectively exhibited 1.572-fold (95% confidence interval (CI) = 1.041-2.375) and 2.335-fold (95% CI = 1.365-3.995) increases in the risk of developing EC relative to those carrying LAPTM4B*1/1. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both p < 0.001). Multivariate analysis showed that LAPTM4B genotype is an independent prognostic factor for OS and DFS (both p < 0.001). These results suggest that LAPTM4B polymorphisms might play an important role in the aetiology of EC.
authors: Department of Gynaecology, The Affiliated Tumour Hospital, Harbin Medical University, Harbin, China.
authors: Fanling
authors: F
authors: Meng
authors: Huiyan
authors: H
authors: Li
authors: Rouli
authors: R
authors: Zhou
authors: Chang
authors: C
authors: Luo
authors: Yuanlong
authors: Y
authors: Hu
authors: Ge
authors: G
authors: Lou
mesh_terms: D000368:Aged; D000483:Alleles; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D002277:Carcinoma / Q000097:blood* / Q000235:genetics / Q000401:mortality / Q000601:surgery; D016022:Case-Control Studies; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000097:blood* / Q000235:genetics / Q000401:mortality / Q000601:surgery; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008565:Membrane Proteins / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D015513:Oncogene Proteins / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D011379:Prognosis; D012306:Risk
chemical_list: D014408:Biomarkers, Tumor; C477083:LAPTM4B protein, human; D008565:Membrane Proteins; D015513:Oncogene Proteins