title: In vitro studies of changes in human endothelial cell functions under the effect of imiquimod.
abstract: Imiquimod (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine) is an active immunomodulator with antiviral effects. In addition to its stimulatory effect on cell-mediated immunity, in vivo studies have detected its antiviral and antiangiogenic effects. Possible direct effect of imiquimod on endothelial cells remains not studied. We have shown that imiquimod inhibited proliferation and migration of human endothelial cells (EA.hy 926 strain) in vitro and induced apoptosis (but not necrosis) of endothelial cells and production of IL-6 cytokine. These results suggest that imiquimod inhibits angiogenesis via direct modulation of endothelial cell function.
authors: Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, Russia.
authors: S A
authors: SA
authors: Kuznetsova
authors: E A
authors: EA
authors: Starikova
authors: I S
authors: IS
authors: Freidlin
authors: V S
authors: VS
authors: Smirnov
mesh_terms: D000634:Aminoquinolines / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D000077271:Imiquimod; D015850:Interleukin-6 / Q000378:metabolism; D018919:Neovascularization, Physiologic / Q000187:drug effects
chemical_list: D000634:Aminoquinolines; D015850:Interleukin-6; D000077271:Imiquimod