title: Environmental genotoxicity and cytotoxicity levels in fish from the North Sea offshore region and Atlantic coastal waters.
abstract: In the framework of the ICON project, environmental genotoxicity and cytotoxicity levels were assessed in blood erythrocytes of dab (Limanda limanda) and haddock (Melanogrammus aeglefinus) collected at 25 stations in the North Sea and near the coast of Iceland in August-October 2008. Micronuclei, nuclear buds and bi-nucleated cells with nucleoplasmic bridges were assessed as environmental genotoxicity biomarkers, and the frequency of fragmented-apoptotic and bi-nucleated erythrocytes were assessed as environmental cytotoxicity biomarkers. The lowest frequencies of genotoxic and cytotoxic abnormalities were detected in fish from the Icelandic study stations. The highest frequencies of abnormalities were recorded in dab from the Dogger Bank and the German Bight, in haddock from the Egersund Bank and from an area off the Firth of Forth (North Sea). In fish from the Icelandic reference area, frequencies of genotoxicity and cytotoxicity responses were significantly lower than in fish from most areas of the North Sea.
authors: Nature Research Centre, Akademijos Str. 2, 08412 Vilnius, Lithuania.
authors: Janina
authors: J
authors: Baršienė
authors: Aleksandras
authors: A
authors: Rybakovas
authors: Thomas
authors: T
authors: Lang
authors: Laura
authors: L
authors: Andreikėnaitė
authors: Aleksandras
authors: A
authors: Michailovas
mesh_terms: D000818:Animals; D001267:Atlantic Ocean; D015415:Biomarkers / Q000378:metabolism*; D004249:DNA Damage; D004784:Environmental Monitoring; D005399:Fishes / Q000378:metabolism*; D009153:Mutagens / Q000378:metabolism*; D009659:North Sea; D018570:Risk Assessment; D017747:Seafood / Q000706:statistics & numerical data; D014874:Water Pollutants, Chemical / Q000378:metabolism* / Q000633:toxicity; D014877:Water Pollution, Chemical / Q000706:statistics & numerical data
chemical_list: D015415:Biomarkers; D009153:Mutagens; D014874:Water Pollutants, Chemical