title: Effects of Mesua ferrea leaf and fruit extracts on growth and morphology of Staphylococcus aureus.
abstract: Mesua ferrea is traditionally used for treating bleeding piles, fever, and renal diseases. It has been reported to have antimircobial activity. In the present study, antibacterial efficacy of leaf and fruit extracts on the growth and morphology of Staphylococcus aureus is evaluated. Both extracts display good antibacterial activity against S. aureus with a minimum inhibition concentration of 0.048 mg/mL. Both extracts are bacteriostatic at a minimum bacteriostatic concentration of 0.39 mg/mL. The bacteriostatic activity lasts for 24 h, and then cells start to grow as normal as shown in time-kill analysis. Scanning electron microscopy study indicated potential detrimental effect of the extracts of leaf and fruits of M. ferrea on the morphology of S. aureus. The treatment with the extracts caused extensive lysis of the cells, leakage of intracellular constituents, and aggregation of cytoplasmic contents forming an open meshwork of the matrix.
authors: School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
authors: Claira Arul
authors: CA
authors: Aruldass
authors: Mani Maran
authors: MM
authors: Marimuthu
authors: Surash
authors: S
authors: Ramanathan
authors: Sharif Mahsufi
authors: SM
authors: Mansor
authors: Vikneswaran
authors: V
authors: Murugaiyah
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001433:Bacteriolysis / Q000187:drug effects; D029624:Ferns / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts