title: The optimal timing for anterior cruciate ligament reconstruction with respect to the risk of postoperative stiffness.
abstract: OBJECTIVE
  The aim of this meta-analysis was to compare the risk of stiffness between early and delayed anterior cruciate ligament (ACL) surgery in studies that use a modern accelerated rehabilitation protocol.
  
  
  METHODS
  Medline, Embase, and the Cochrane library were searched for studies that compared outcomes for early and delayed ACL reconstruction with a modern accelerated rehabilitation protocol. Risk ratios for stiffness were pooled using random effects meta-analysis.
  
  
  RESULTS
  A total of 8 studies were included in this review. The 3 randomized trials found no difference in the risk of postoperative stiffness at cutoff points of <2, <3, and <10 weeks between early surgery and delayed surgery. An analysis of the 7 studies whose outcomes could be pooled revealed no significant increase in risk of adverse outcomes with early surgery using a variety of cutoff points (1, 2, 10, 12, and 20 weeks). Sensitivity analysis of individual outcomes failed to show any significant difference between early and delayed surgery with respect to arthrofibrosis, stiffness, range of motion deficits, extension deficits, and flexion deficits.
  
  
  CONCLUSIONS
  If a modern surgical technique and an accelerated rehabilitation protocol are used, there is no increased risk of knee stiffness if an ACL reconstruction is performed as early as 1 week after injury.
  
  
  METHODS
  Level II, meta-analysis of Level I and II studies.
authors: Department of Trauma and Orthopaedics, Ipswich Hospital NHS Trust, Health Road, Ipswich, Suffolk, England. shingkwok@doctors.org.uk
authors: Chun Shing
authors: CS
authors: Kwok
authors: Tim
authors: T
authors: Harrison
authors: Chris
authors: C
authors: Servant
mesh_terms: D000328:Adult; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D000070598:Anterior Cruciate Ligament Injuries; D059549:Anterior Cruciate Ligament Reconstruction / Q000009:adverse effects / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000209:etiology* / Q000503:physiopathology / Q000534:rehabilitation; D007718:Knee Injuries / Q000503:physiopathology / Q000534:rehabilitation / Q000601:surgery*; D008297:Male; D016059:Range of Motion, Articular; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult