title: Assessment of femoral artery atherosclerosis at the adductor canal using 3D black-blood MRI.
abstract: OBJECTIVE
  To assess whether the three-dimensional (3D) black-blood motion-sensitized driven equilibrium (MSDE) prepared rapid gradient-echo sequence (3D MERGE) magnetic resonance imaging (MRI) sequence is sensitive enough to detect differences in atherosclerotic plaque size and morphology occurring in the adductor canal and the proximal bifurcation segment.
  
  
  METHODS
  Fifty pairs of adductor canal and bifurcation segments from 25 patients with intermittent claudication were examined using 3D MERGE. The two-dimensional (2D) transverse section showing the largest plaque burden in each segment was chosen for comparison. Wall and lumen boundaries were segmented from each 2D section and quantified using six metrics: wall area (WA), lumen area (LA), normalized wall index (NWI), maximum wall thickness (MaxWT), minimum wall thickness (MinWT), and eccentricity.
  
  
  RESULTS
  The mean LA in the adductor region was significantly lower than that in the bifurcation segment (p < 0.0001). Mean NWI, MaxWT, and eccentricity in the adductor region were significantly higher than those at bifurcation (p < 0.0001, p < 0.0021, and p < 0.0045, respectively). Mean WA and MinWT of the two segments did not show a statistically significant difference. WA in both regions was positively correlated with eccentricity (p < 0.0049 and p < 0.0049, respectively). LA was negatively correlated with eccentricity (p < 0.0017), and NWI was positively correlated with eccentricity only in the adductor region (p < 0.0004).
  
  
  CONCLUSIONS
  The results suggest that compensatory enlargement was limited in the adductor canal when compared to the proximal bifurcation segment. 3D MERGE, as a fast and non-invasive sequence, may assist the evaluation of femoral atherosclerosis by assessing the size and morphology of plaques, knowledge of which can guide clinical treatment.
authors: Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors: J
authors: J
authors: Chi
authors: B
authors: B
authors: Chiu
authors: Y
authors: Y
authors: Cao
authors: X
authors: X
authors: Liu
authors: J
authors: J
authors: Wang
authors: N
authors: N
authors: Balu
authors: C
authors: C
authors: Yuan
authors: J
authors: J
authors: Xu
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000473:pathology*; D005260:Female; D005263:Femoral Artery / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D012680:Sensitivity and Specificity