title: Coronary stent thrombosis: current insights into new drug-eluting stent designs.
abstract: The advances of interventional cardiology have been achieved by new device development, finding appropriate drug regimes, and understanding of pathomechanism. Drug-eluting stents (DES) implantation with dual anti-platelet therapy reduced revascularization without increasing mortality or myocardial infarction compared with bare-metal stenting. However, late-term stent thrombosis (ST) and restenosis limited its value and raised the safety concern. Main mechanisms of this phenomenon are impaired endothelialization and hypersensitivity reaction with polymer. The second generation DES further improved safety and/or efficacy by using thinner stent strut and biocompatible polymer. Recently, new concept DES with biodegradable polymer, polymer-free and bioabsorbable scaffold are under investigation in the quest to minimize the risk of ST.
authors: The Heart Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Korea. ; Korea Cardiovascular Stent Research Institute, Chonnam National University, Gwangju, Korea.
authors: Hyun Kuk
authors: HK
authors: Kim
authors: Myung Ho
authors: MH
authors: Jeong
keywords: Blood platelets; Coronary thrombosis; Drug-eluting stents