title: Outcome of resection of infratemporal fossa tumors.
abstract: BACKGROUND
  A variety of tumors arise in or extend to the infratemporal fossa. We investigated the outcome of surgical management of these tumors.
  
  
  METHODS
  We conducted a retrospective review of a craniofacial approach to resection of infratemporal fossa tumors from 1992 to 2008 in a cancer center.
  
  
  RESULTS
  Forty-three patients underwent resection of a infratemporal fossa tumors (68% men). Median age was 46 years (range, 1-81 years). The most common pathology was sarcoma (13; 30%). Twenty-two tumors (51%) were recurrent. Twenty patients (46%) underwent resection of tumors from the infratemporal fossa, 5 (12%) required resection of the anterior skull base, and 18 (42%) required orbital exenteration, additionally. Thirty-one patients (72%) required reconstruction with free tissue transfer. Twenty-seven patients (62.8%) required further treatment with radiation and/or chemotherapy. Complications occurred in 9 patients (21%). Six patients (14%) underwent salvage operations. Median follow-up was 24 months. Median overall survival and 3-year survival were 40 months and 59.6%.
  
  
  CONCLUSIONS
  Tumors involving the infratemporal fossa can be resected with acceptable morbidity and long-term survival.
authors: Department of Otolaryngology, Head and Neck Surgery, New York University, New York, NY.
authors: Babak
authors: B
authors: Givi
authors: Jeffrey
authors: J
authors: Liu
authors: Mark
authors: M
authors: Bilsky
authors: Babak
authors: B
authors: Mehrara
authors: Joseph
authors: J
authors: Disa
authors: Andrea
authors: A
authors: Pusic
authors: Peter
authors: P
authors: Cordeiro
authors: Jatin P
authors: JP
authors: Shah
authors: Dennis H
authors: DH
authors: Kraus
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D035301:Cranial Fossa, Middle / Q000473:pathology / Q000601:surgery; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology*; D019635:Neurosurgical Procedures / Q000379:methods* / Q000401:mortality; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis; D019651:Plastic Surgery Procedures / Q000379:methods* / Q000401:mortality; D012189:Retrospective Studies; D018570:Risk Assessment; D019291:Skull Base / Q000473:pathology / Q000601:surgery; D019292:Skull Base Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
keywords: infratemporal fossa; skull base tumors; surgical treatment; survival