title: ΔNp63 promotes UM‑UC‑3 cell invasiveness and migration through claudin‑1             in vitro.
abstract: The p63 gene, a member of the p53 gene family, has two different promoter             usage‑generating proteins that contain or lack (ΔN) an NH2‑terminus. Although             p53 and p63 have high sequence and structural similarities, the molecules differ             in function and expression profiles. p63 is critical for the development of epithelial             organs or tissues, including the epidermis and other squamous epithelia, as well             as the salivary, lachrymal, mammary and prostate glands and the urothelium. In             addition, p63 is essential for the proliferative potential of stem cells in the             epidermis. In contrast to p53, the role of ΔNp63 in tumors remains unclear and             complex. Our previous study demonstrated that ΔNp63 is overexpressed in human             bladder carcinoma tissues. The mechanism by which ΔNp63 promotes tumor cell development,             including adhesion, proliferation and polarity, is unknown. Data demonstrate that             ΔNp63 induces the invasiveness of cancer cells through specific downstream genes             and the mechanism is associated with cell junctions. Claudin‑1 is an important             p63 target gene for normal skin development. Claudin‑1, as a connexin, functions             in a similar manner to other connexins to affect important events during cancer             cell development. In the present study, ΔNp63 gene expression in bladder tumor             tissues was found to be significantly higher than that in normal tissue, indicating             that ΔNp63 is localized to the nucleus. In addition, ΔNp63 silencing decreased             invasion and metastasis in UM‑UC‑3 cells and reduced claudin‑1 expression.
authors: Clinical Medical College, North Sichuan Medical College, Nan Chong 637000, PR China.
authors: Peng
authors: P
authors: Jing
authors: Jiaqiong
authors: J
authors: Zou
authors: Jun
authors: J
authors: Zhang
authors: Xingliang
authors: X
authors: Jiang
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement; D062445:Claudin-1 / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D034622:RNA Interference; D012333:RNA, Messenger / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D062445:Claudin-1; D012333:RNA, Messenger; D034741:RNA, Small Interfering; C115051:TP63 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins