title: In vitro free radical scavenging and anti-hyperglycemic activities of Achyranthes aspera extract in alloxan-induced diabetic mice.
abstract: Medicinal plants have played an important role in the treatment and prevention of diseases since ancient times. They are also potential sources of nutrients and drugs. This study evaluated Achyranthes aspera ethanolic extracts for their in vitro antioxidant activity and anti-hyperglycemic effects on alloxan-induced diabetic mice. Diabetes was induced in Swiss albino mice through intra-peritoneal administration of alloxan and their blood glucose levels and weight were measured weekly. At the end of the experiment, all animals were sacrificed and tissue samples were collected. A. aspera extracts had potent antioxidant activity compared to reference standard compounds. Treatment with an A. aspera extract at doses of 200 mg/kg and 400 mg/kg significantly reduced blood glucose levels in alloxan-induced diabetic mice. A. aspera extract also prevented lipid peroxidation as gauged by thiobarbituric acid reactive substances (TBARS) and hydroperoxides. Moreover, A. aspera extract increased the activity of catalase and reduced NO levels in alloxan-induced diabetic mice. Results revealed significant anti-hyperglycemic activity of A. aspera extracts in alloxan-treated mice that may be mediated by diminished oxidative stress.
authors: Pharmacognosy and Pharmacology Laboratory, Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh.
authors: Fatema Zohura
authors: FZ
authors: Talukder
authors: Kousik Ahmed
authors: KA
authors: Khan
authors: Riaz
authors: R
authors: Uddin
authors: Nusrat
authors: N
authors: Jahan
authors: Md Ashraful
authors: MA
authors: Alam
mesh_terms: D029044:Achyranthes; D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D016166:Free Radical Scavengers; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D009569:Nitric Oxide; D000496:Alloxan