title: Phosphodiesterase-5 expression and function in the lower urinary tract: a critical review.
abstract: Both clinical and preclinical studies have mostly shown beneficial effects for Phosphodiesterase-5 (PDE-5) inhibitors in the treatment of lower urinary tract symptoms. Molecular studies have consistently shown abundant PDE-5 expression in bladder smooth muscle. Data concerning urethral PDE-5 expression have been surprising because striated muscle was not only positively identified, but also found to express more PDE-5 than the smooth muscle. In the prostate, highly variable results have been obtained. For PDE-5 expression, the data have ranged from extremely low to highly abundant. PDE-5 has been found in the glandular epithelium, vascular smooth muscle, endothelium, and fibromuscular stroma.
authors: Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143-0738, USA. clin@urology.ucsf.edu
authors: Ching-Shwun
authors: CS
authors: Lin
authors: Maarten
authors: M
authors: Albersen
authors: Zhongcheng
authors: Z
authors: Xin
authors: Mikio
authors: M
authors: Namiki
authors: Dieter
authors: D
authors: Muller
authors: Tom F
authors: TF
authors: Lue
mesh_terms: D000818:Animals; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5 / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D014521:Urethra / Q000502:physiology*; D001743:Urinary Bladder / Q000502:physiology*
chemical_list: D054706:Cyclic Nucleotide Phosphodiesterases, Type 5