title: PPAR-gamma Pro12Ala polymorphism and gastric cancer risk in a Turkish population.
abstract: BACKGROUND
  Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand dependent transcription factor involved in various processes, including carcinogenesis. We aimed to investigate any possible association of the PPARγPro12Ala (rs1801282) polymorphism with risk of developing gastric cancer (GC).
  
  
  METHODS
  A hospital based case control study was designed covering 50 patients with GC and 120 healthy controls. The frequencies of PPARγPro12Ala (rs1801282) were determined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.
  
  
  RESULTS
  The Ala12 allele of the PPARγPro12Ala G gene was associated with a 1.95 fold increased risk of GC development (p: 0.022; 95% CI: 1.58-2.40). Subgroup analyses showed that the same allele was also associated with metastasis (p: 0.000; OR:4.09; 95%CI:2.273-7.368) and differentiation (p: 0.004; OR:1.95; 95%CI:1.335-2.875) in patients with GC.
  
  
  CONCLUSIONS
  This study suggests that the PPARγPro12Ala G (Ala12) allele might be associated with development, differentiation and metastatic process of GC in the Turkish population. Further studies conducted in larger study groups and in different ethnic populations will be needed to clarify the exact role of the PPARγPro12Ala polymorphism in GC.
authors: National Peritoneal Organization to support Peritoneal Dissemination Treatment, Department of General Surgery, Kishiwada Tokushukai Hospital, Osaka, Japan. dremelcanbay@gmail.com
authors: Emel
authors: E
authors: Canbay
authors: Ozlem
authors: O
authors: Kurnaz
authors: Bahar
authors: B
authors: Canbay
authors: Dursun
authors: D
authors: Bugra
authors: Bedia
authors: B
authors: Cakmakoglu
authors: Turker
authors: T
authors: Bulut
authors: Sumer
authors: S
authors: Yamaner
authors: Necmettin
authors: N
authors: Sokucu
authors: Yilmaz
authors: Y
authors: Buyukuncu
authors: Hulya
authors: H
authors: Yilmaz-Aydogan
mesh_terms: D016022:Case-Control Studies; D002454:Cell Differentiation; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D047495:PPAR gamma / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D014421:Turkey / Q000453:epidemiology
chemical_list: D047495:PPAR gamma