title: Olanzapine treatment for tics in an adult woman with severe tourette syndrome.
abstract: OBJECTIVE
  Olanzapine had been reported to be effective in the control of tics in a few adult female patients who had a short follow-up period. The author reports the successful outcome of long-term olanzapine treatment in an adult woman with severe Tourette syndrome.
  
  
  METHODS
  A 33-year-old woman who had severe motor and vocal tics (Modified Rush Videotape Rating Scale: 17/20) showed an excellent response to olanzapine 10 mg/day within 2 months. Her tic symptoms were well controlled with gradual reduction of her dose of olanzapine to 2.5 mg/day during the following 8 years. She was symptom-free without medications in the past 2 years. In addition, she had a normal menstrual cycle and became pregnant during the period of olanzapine treatment.
  
  
  CONCLUSIONS
  Olanzapine may be the drug of first choice for treating severe Tourette syndrome in pubescent female adolescents and young women who wish to have children.
authors: Department of Neurology, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan. wjhwang@mail.ncku.edu.tw
authors: Wen-Juh
authors: WJ
authors: Hwang
mesh_terms: D000328:Adult; D001569:Benzodiazepines / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000077152:Olanzapine; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012720:Severity of Illness Index; D020323:Tics / Q000188:drug therapy* / Q000209:etiology*; D005879:Tourette Syndrome / Q000150:complications*
chemical_list: D001569:Benzodiazepines; D000077152:Olanzapine; D017367:Selective Serotonin Reuptake Inhibitors