title: Monoclonal origin of primary unilateral multifocal pleomorphic adenoma of the parotid gland.
abstract: Primary multiple pleomorphic adenomas in a unilateral parotid gland in previously untreated patients is a rare finding, and little is known about the etiology and pathogenesis. Here, a highly unusual case of a primary multifocal pleomorphic adenoma consisting of 15 individual nodules is presented. It is shown that all nodes are clonally related and thus share a common cell of origin excluding an independent multifocal pathogenesis. Most likely, multifocal pleomorphic adenoma represents parasitic nodules that have been detached from a main nodule, which may have been the result of undisclosed trauma.
authors: Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, The Netherlands. S.L.vanegmond@umcutrecht.nl
authors: Sylvia L
authors: SL
authors: van Egmond
authors: Wendy W J
authors: WW
authors: de Leng
authors: Folkert H M
authors: FH
authors: Morsink
authors: G Johan A
authors: GJ
authors: Offerhaus
authors: Lodewijk A A
authors: LA
authors: Brosens
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010306:Parotid Gland / Q000473:pathology; D010307:Parotid Neoplasms / Q000473:pathology*; D049951:X Chromosome Inactivation