title: Association of HLA-DRB1 single nucleotide polymorphisms with left ventricular remodelling in elderly patients with essential hypertension.
abstract: OBJECTIVE
  To investigate the associations between human leucocyte antigen DRβ1 (HLA-DRB1) gene polymorphisms and cardiovascular remodelling (left ventricular dilatation [LVD]) in Han Chinese patients ≥ 60 years old, with essential hypertension.
  
  
  METHODS
  LVD was diagnosed via echocardiographic measurements. Multiplex polymerase chain reaction-ligase detection reaction was used to determine the genotypes of three HLA-DRB1 single nucleotide polymorphisms (SNPs; rs2308765, rs9269186 and rs3135388).
  
  
  RESULTS
  HLADRB1 rs2308765 wild-type (G) allele and genotype (GG) were associated with decreased risk of LVD. HLA-DRB1 rs9269186 and rs3135388 were not associated with LVD risk. Mean waist and abdominal circumferences were significantly larger in patients with, compared with those without, LVD. Multivariate logistic regression analyses found that rs2308765 was associated with LVD (GT + TT versus GG; odds ratio 7.958; 95% confidence interval 1.935, 32.723).
  
  
  CONCLUSIONS
  Mutation in HLA-DRB1 rs2308765 was associated with increased risk of LVD in elderly patients with hypertension. Genotype analysis may allow identification of patients at high risk of cardiovascular events such LVD.
authors: First Hospital, Jilin University, Changchun, China.
authors: Q M
authors: QM
authors: Li
authors: B
authors: B
authors: Li
authors: Y F
authors: YF
authors: Sun
authors: H
authors: H
authors: Zhang
authors: X L
authors: XL
authors: Yang
authors: L W
authors: LW
authors: Cai
authors: H
authors: H
authors: Chen
authors: Y H
authors: YH
authors: Ding
authors: J
authors: J
authors: Jiang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020257:Ventricular Remodeling / Q000235:genetics*; D055105:Waist Circumference / Q000235:genetics
chemical_list: D059811:HLA-DRB1 Chains