title: Herpes zoster as a cause of viral meningitis in immunocompetent patients.
abstract: A 30-year-old Caucasian woman, without significant medical history or immunosuppression, presented with a 7-day history of severe headache and neck pain. The patient was presumed to have tension headache versus migraine, but was admitted because her symptoms did not resolve. A lumbar puncture was performed showing lymphocytic pleocytosis suggestive of aseptic meningitis and the patient was started on broad-spectrum antibiotics and acyclovir. After admission, a rash was discovered on her left lumbar region with vesicles on top of an erythematous base. Varicella PCR was conducted on the patient's cerebrospinal fluid which was positive. Upon further history, patient was found to have previous varicella infection as a child, but no prior episodes of dermatomal zoster. Therefore, this patient was found to have aseptic meningitis and cutaneous manifestation of disseminated varicella-zoster despite immunocompetence. Antibacterial treatment was discontinued and she was continued on acyclovir for 7 days with transition to valacyclovir for 2 additional weeks with good treatment response and symptom resolution.
authors: Texas A&M School of Medicine, Temple, Texas, USA. drraghesh.vk@gmail.com
authors: Raghesh Varot
authors: RV
authors: Kangath
authors: Tracey Einem
authors: TE
authors: Lindeman
authors: Karen
authors: K
authors: Brust
mesh_terms: D000328:Adult; D002555:Cerebrospinal Fluid / Q000821:virology; D004279:DNA, Viral / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006562:Herpes Zoster / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D014645:Herpesvirus 3, Human / Q000235:genetics*; D006801:Humans; D008587:Meningitis, Viral / Q000175:diagnosis / Q000209:etiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D013129:Spinal Puncture
chemical_list: D004279:DNA, Viral