title: Genetic association between RGS1 and internalizing disorders.
abstract: OBJECTIVE
  Quantitative trait loci identified in animal models provide potential candidate susceptibility loci for human disorders. In this study, we investigated whether internalizing disorders (anxiety disorders, major depression, and neuroticism) were associated with a region on human chromosome 1 syntenic with a quantitative trait locus for rodent emotionality.
  
  
  METHODS
  We genotyped 31 single-nucleotide polymorphisms in genes located on chromosome 1q31.2 in a two-stage association study of 1128 individuals chosen for a high or a low genetic risk for internalizing disorders from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders.
  
  
  RESULTS
  None of the individual single-nucleotide polymorphisms showed consistent association across stages. A four-marker haplotype in the regulator of G-protein signaling 1 gene (RGS1) was significantly associated with decreased internalizing risk in both stages, whereas another showed a nominal association with a higher risk.
  
  
  CONCLUSIONS
  Our data suggest that markers in the RGS1 gene might be in linkage disequilibrium with a protective allele that reduces the risk of anxiety and depressive disorders.
authors: Departments of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA 23298-0126, USA.
authors: John M
authors: JM
authors: Hettema
authors: Seon-Sook
authors: SS
authors: An
authors: Edwin J C G
authors: EJ
authors: van den Oord
authors: Michael C
authors: MC
authors: Neale
authors: Kenneth S
authors: KS
authors: Kendler
authors: Xiangning
authors: X
authors: Chen
mesh_terms: D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D009497:Neurotic Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D020710:RGS Proteins / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D020710:RGS Proteins; C080831:RGS1 protein, human