title: Overview of admixture mapping.
abstract: Admixture mapping is a powerful method of gene mapping for diseases or traits that show differential risk by ancestry. Admixture mapping has been applied most often to African Americans who trace ancestry to Europeans and West Africans. Recent developments in admixture mapping include improvements in methods to take advantage of higher densities of genetic variants, as well as extensions to admixed populations with three or more ancestral populations, such as Latino Americans. In this unit, the author outlines the key concepts of admixture mapping. The author describes several approaches for inferring local ancestry and provides strategies for performing admixture mapping depending on the study design. Finally, the author compares and contrasts linkage analysis, association analysis, and admixture mapping, with an emphasis on integrating admixture mapping and association testing.
authors: Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, USA.
authors: Daniel
authors: D
authors: Shriner
mesh_terms: D001741:Black or African American / Q000235:genetics; D044383:Black People / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods*; D056726:Genetic Association Studies / Q000379:methods; D008040:Genetic Linkage; D015894:Genome, Human; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D010641:Phenotype; D040641:Quantitative Trait Loci; D044465:White People / Q000235:genetics