title: CT and physiologic determinants of dyspnea and exercise capacity during the six-minute walk test in mild COPD.
abstract: OBJECTIVE
  We aimed to explore physiological responses to the six-minute walk test (6MWT) and assess computed tomographic (CT) features of the lungs and thigh muscle in order to determine contributors to dyspnea intensity and exercise limitation in dyspneic and non-dyspneic subjects with GOLD-1 COPD and controls.
  
  
  METHODS
  We compared Borg dyspnea ratings, ventilatory responses to 6MWT, and CT-measures of emphysema, airway lumen caliber, and cross-sectional area of the thigh muscle (RTMCT-CSA) in 19 dyspneic, 22 non-dyspneic, and 30 control subjects.
  
  
  RESULTS
  Dyspneic subjects walked less and experienced greater exertional breathlessness than non-dyspneic (105 m less and 2.4 Borg points more, respectively) and control subjects (94 m less and 2.6 Borg points more, respectively (P < 005 for all comparisons). At rest, dyspneic subjects had significant greater expiratory airflow obstruction, air trapping, ventilation/perfusion mismatch, burden of emphysema, narrower airway lumen, and lower RTMCT-CSA than comparison subjects. During walking dyspneic subjects had a decreased inspiratory capacity (IC) along with high ventilatory demand. Dyspneic subjects exhibited higher end-exercise tidal expiratory flow limitation and oxygen saturation drop than comparison subjects. In regression analysis, dyspnea intensity was best explained by ΔIC and forced expiratory volume in 1 s %predicted. RTMCT-CSA and ΔIC were independent determinants of distance walked.
  
  
  CONCLUSIONS
  Among subjects with mild COPD, those with daily-life dyspnea have worse exercise outcomes; distinct lung and thigh muscle morphologic features; and different pulmonary physiologic characteristics at rest and exercise. ΔIC was the main contributor to dyspnea intensity and ΔIC and thigh muscle wasting were determinants of exercise capacity.
authors: Division of Pulmonary and Critical Care, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: Alejandro A
authors: AA
authors: Díaz
authors: Arturo
authors: A
authors: Morales
authors: Juan C
authors: JC
authors: Díaz
authors: Cristóbal
authors: C
authors: Ramos
authors: Julieta
authors: J
authors: Klaassen
authors: Fernando
authors: F
authors: Saldías
authors: Carlos
authors: C
authors: Aravena
authors: Rodrigo
authors: R
authors: Díaz
authors: Carmen
authors: C
authors: Lisboa
authors: George R
authors: GR
authors: Washko
authors: Orlando
authors: O
authors: Díaz
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D004417:Dyspnea / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D005080:Exercise Test / Q000379:methods; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000473:pathology; D010101:Oxygen Consumption / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D015656:Respiratory Mechanics / Q000502:physiology; D013848:Thigh / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016138:Walking / Q000502:physiology