title: Fate specification in the adult brain--lessons for eliciting neurogenesis from glial cells.
abstract: In the adult mammalian brain, neurogenesis is restricted to few regions, while gliogenesis continues in a wide-spread manner. Here we discuss our knowledge of extrinsic and intrinsic factors regulating neuro- and gliogenesis in the adult brain and propose a model of fate specification identifying the states of easiest transition between glio- and neurogenesis, highlighting the unique mechanisms stabilising the neural stem cell state. The model also encompasses the fate alterations achieved by direct reprogramming, and hence addresses a novel avenue for repair, namely eliciting neurogenesis from glial cells outside the neurogenic niches.
authors: Helmholtz Centre Munich German Research Centre for Environmental Health (GmbH), Institute for Stem Cell Research, Neuherberg/Munich, Germany. ninkovic@helmholtz-muenchen.de
authors: Jovica
authors: J
authors: Ninkovic
authors: Magdalena
authors: M
authors: Götz
mesh_terms: D000328:Adult; D000818:Animals; D001921:Brain / Q000166:cytology*; D019070:Cell Lineage; D006801:Humans; D008954:Models, Biological; D055495:Neurogenesis; D009457:Neuroglia / Q000166:cytology*; D055153:Stem Cell Niche