title: Crystallization and dissolution behavior of naproxen/polyethylene glycol solid dispersions.
abstract: The crystallization kinetics of naproxen (NAP) in NAP/polyethylene glycol (NAP/PEG) solid dispersions prepared at different crystallization temperatures was studied by in situ small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS). It was found that the crystallization rate of NAP was faster at 25 °C in comparison to 40 °C. This resulted in different sizes of NAP domains, and consequently impacted the dissolution behavior. The sizes of NAP domains prepared at 40 °C were larger than those at 25 °C, as determined with surface area analysis, utilizing second-order nonlinear optical imaging of chiral crystals (SONICC). Consistent with this observation, the corresponding dissolution rate of the NAP/PEG dispersion prepared at 40 °C was indeed slower than that prepared at 25 °C. The microstructure of the NAP/PEG solid dispersions and the dissolution behavior also showed a dependence on the chemical composition of the solid dispersions.
authors: School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
authors: Qing
authors: Q
authors: Zhu
authors: Scott J
authors: SJ
authors: Toth
authors: Garth J
authors: GJ
authors: Simpson
authors: Hsin-Yun
authors: HY
authors: Hsu
authors: Lynne S
authors: LS
authors: Taylor
authors: Michael T
authors: MT
authors: Harris
mesh_terms: D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D007700:Kinetics; D009288:Naproxen / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; D011092:Polyethylene Glycols; D009288:Naproxen