title: Common genetic variants of the natriuretic peptide gene locus are not associated with heart failure risk in participants in the EPIC-Norfolk study.
abstract: OBJECTIVE
  BNP has important effects on haemodynamics and myocardial remodelling which are protective from development and progression of heart failure. The aim of this study was to examine whether three common genetic variants (rs198389, rs5068, and rs198358) within or adjacent to the BNP gene locus which were shown to be associated with BNP blood levels are associated with risk of heart failure in the pospective population-based EPIC-Norfolk cohort.
  
  
  RESULTS
  The hazard ratio on heart failure was calculated in 23 192 participants in the EPIC-Norfolk study with Cox proportional regression analyses. During a mean follow-up of 12.6 years, 1673 (7.2%) participants had a heart failure event. There was no significant association between genotypes of rs198389, rs5068, and rs198358 and heart failure risk. Results did not differ materially in analyses stratified by hypertension, obesity, and coronary heart disease.
  
  
  CONCLUSIONS
  Common genetic variants reported to be associated with BNP levels were not associated with a relevant risk of heart failure in our population-based cohort. However, we cannot exclude a small association with risk of heart failure or an association with individual subtypes of the heart failure syndrome.
authors: Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK. roman.pfister@uk-koeln.de
authors: Roman
authors: R
authors: Pfister
authors: Robert N
authors: RN
authors: Luben
authors: Kay-Tee
authors: KT
authors: Khaw
authors: Nick J
authors: NJ
authors: Wareham
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics*; D006333:Heart Failure / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood / Q000235:genetics*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D020097:Natriuretic Peptide, Brain
keywords: Brain natriuretic peptide; Heart failure; Single nucleotide polymorphism