title: Using next generation sequencing to tackle non-typhoidal Salmonella infections.
abstract: The publication of studies using next generation sequencing to analyse large numbers of bacterial isolates from global epidemics is transforming microbiology, epidemiology and public health. The emergence of multidrug resistant Salmonella Typhimurium ST313 is one example. While the epidemiology in Africa appears to be human-to-human spread and the association with invasive disease almost absolute, more needs to be done to exclude the possibility of animal reservoirs and to transfer the ability to track all Salmonella infections to the laboratories in the front line. In this mini-review we summarise what is currently known about non-typhoidal Salmonella in sub-Saharan Africa and discuss some of the issues which remain.
authors: Norwich Medical School, University of East Anglia, Norwich, UK. j.wain@uea.ac.uk
authors: John
authors: J
authors: Wain
authors: Karen H
authors: KH
authors: Keddy
authors: Rene S
authors: RS
authors: Hendriksen
authors: Salvatore
authors: S
authors: Rubino
mesh_terms: D017954:Africa South of the Sahara; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004269:DNA, Bacterial / Q000235:genetics; D004197:Disease Reservoirs / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D012480:Salmonella Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D012481:Salmonella Infections, Animal / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D012486:Salmonella typhimurium / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial