title: The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses.
abstract: Interactions between several tumor necrosis factor (TNF)-TNF receptor (TNFR) superfamily members that are expressed by T cells and natural killer (NK) cells and various other cell types modulate immune responses. This review summarizes the current understanding of how the TNF ligand-TNFR interactions 4-1BBL with 4-1BB, and GITRL with glucocorticoid-induced TNFR-related (GITR) regulate NK cell mediated antitumor responses and discuss its therapeutic implications.
authors: Department of Microbiology and Immunology, University of Nevada, Reno Reno, NV, USA.
authors: Isabel
authors: I
authors: Barao
keywords: 4-1BB; GITR; NK; leukemia; therapy