title: Incidence and risk factors for hospital-acquired Clostridium difficile infection among inpatients in an orthopaedic tertiary care hospital.
abstract: The aim of this retrospective study was to identify risk factors for hospital-acquired Clostridium difficile infection (HA-CDI) in orthopaedic patients. Thirty-two HA-CDI cases were each matched with two controls. Incidence rate was 0.33 cases per 1000 patient-days. Univariate analyses showed that surgery >24 h after admission, antibiotics for treatment, and proton pump inhibitors were associated with HA-CDI. Multivariate analyses revealed that surgery >24 h after admission was associated with HA-CDI. Patients hospitalized before surgery had a greater risk of HA-CDI, suggesting opportunities to reduce environmental exposure to C. difficile by timelier preoperative medical optimization in the outpatient setting.
authors: Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, New York, NY, USA.
authors: K A
authors: KA
authors: Campbell
authors: M S
authors: MS
authors: Phillips
authors: A
authors: A
authors: Stachel
authors: J A
authors: JA
authors: Bosco
authors: S A
authors: SA
authors: Mehta
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000453:epidemiology* / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D015994:Incidence; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D009985:Orthopedics; D012189:Retrospective Studies; D012307:Risk Factors; D062606:Tertiary Care Centers