title: Guidelines for the use of human immunoglobulin therapy in patients with primary immunodeficiencies in Latin America.
abstract: Antibodies are an essential component of the adaptative immune response and hold long-term memory of the immunological experiences throughout life. Antibody defects represent approximately half of the well-known primary immunodeficiencies requiring immunoglobulin replacement therapy. In this article, the authors review the current indications and therapeutic protocols in the Latin American environment. Immunoglobulin replacement therapy has been a safe procedure that induces dramatic positive changes in the clinical outcome of patients who carry antibody defects.
authors: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: condino@icb.usp.br.
authors: A
authors: A
authors: Condino-Neto
authors: Department of Pediatrics, School of Medicine, Federal University of São Paulo, São Paulo, Brazil.
authors: B T
authors: BT
authors: Costa-Carvalho
authors: Department of Medicine, Faculty of Medicine ABC, São Paulo, Brazil.
authors: A S
authors: AS
authors: Grumach
authors: Hospital Luis Calvo Mackenna, Santiago, Chile.
authors: A
authors: A
authors: King
authors: Immunology Group, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.
authors: L
authors: L
authors: Bezrodnik
authors: Division of Immunology, Hospital Juan P Garrahan, Buenos Aires, Argentina.
authors: M
authors: M
authors: Oleastro
authors: Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
authors: L
authors: L
authors: Leiva
authors: Immunology and Pediatric Rheumatology, Hospital Nacional de Niños Dr Carlos Sáenz Herrera, San José, Costa Rica.
authors: O
authors: O
authors: Porras
authors: Unidad de Investigación en Inmunodeficiencias, Instituto Nacional de Pediatría, Mexico City, Mexico.
authors: F J
authors: FJ
authors: Espinosa-Rosales
authors: Primary Immunodeficiencies Group, University of Antioquia, Medellin, Colombia.
authors: J L
authors: JL
authors: Franco
authors: Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Faculty of Medicine, University of La Frontera, Temuco, Chile.
authors: R U
authors: RU
authors: Sorensen
mesh_terms: D017408:Guidelines as Topic; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy*; D007843:Latin America
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: Guidelines; Immunoglobulin replacement therapy; Intravenous immunoglobulin; Latin America; Primary immunodeficiency; Subcutaneous immunoglobulin