title: Antiretroviral activity of protease inhibitors against Toxoplasma gondii.
abstract: The introduction of highly active antiretroviral therapy (HAART) has caused a marked reduction in the occurrence and severity of parasitic infections, including the toxoplasmic encephalitis (TE). These changes have been attributed to the restoration of cell-mediated immunity. This study was developed to examine the activity of six antiretroviral protease inhibitors (API) on Toxoplasma gondii tachyzoites. The six API showed anti-Toxoplasma activity, with IC50 value between 1.4 and 6.6 µg/mL. Further studies at the molecular level should be performed to clarify if the use of API could be beneficial or not for AIDS patients with TE.
authors: Parasitology Department, Institute of Tropical Medicine Pedro Kouri, Havana, Cuba.
authors: Lianet
authors: L
authors: Monzote
authors: Marta
authors: M
authors: Rodríguez
authors: Yenisey
authors: Y
authors: Alfonso
authors: Raymundo
authors: R
authors: Cox
mesh_terms: D000818:Animals; D005260:Female; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D007928:Lethal Dose 50; D051379:Mice; D021261:Parasitic Sensitivity Tests; D014122:Toxoplasma / Q000187:drug effects*
chemical_list: D017320:HIV Protease Inhibitors