title: Steroidal and non-steroidal cyclooxygenase-2 inhibitor anti-inflammatory drugs as pre-emptive medication in patients undergoing periodontal surgery.
abstract: The aim of the present study was to compare the pre-emptive use of a cyclooxygenase-2 (COX-2) inhibitor with a well established steroidal anti-inflammatory drug for pain and edema relief following periodontal surgery for crown lengthening. Thirty patients requiring periodontal surgery were randomly assigned to receive one of the following medications: selective COX-2 inhibitor or steroidal anti-inflammatory drug, 60 min before the surgical procedure. To examine patient anxiety, a Corah's dental anxiety scale was applied before surgery. Using a visual analog scale, the extent of pain/discomfort during the trans-operative period and immediately after the surgery was measured. Additionally, intensity of pain/discomfort and edema were examined 4, 8, 12 and 24 h postoperatively. With regard to anxiety, no statistical differences between the groups were observed (p>0.05). With respect to the extent of pain/discomfort during the trans-operative, immediate and late postoperative period, data demonstrated no significant differences (p>0.05) between the COX-2 inhibitor and steroidal groups. With regard to edema, intragroup analysis did not reveal any statistically significant difference (p>0.05) during the 24 h following surgery in either group. In conclusion, both anti-inflammatory drugs presented a similar potential for pain and edema relief following periodontal surgery.
authors: Department of Prosthodontics and Periodontics, Piracicaba Dental School, UNICAMP - University of Campinas, Piracicaba, SP, Brazil.
authors: Maria Fernanda Santos
authors: MF
authors: Peres
authors: Fernanda Vieira
authors: FV
authors: Ribeiro
authors: Karina Gonzalez Silvério
authors: KG
authors: Ruiz
authors: Francisco Humberto
authors: FH
authors: Nociti
authors: Enilson Antônio
authors: EA
authors: Sallum
authors: Márcio Zaffalon
authors: MZ
authors: Casati
mesh_terms: D000328:Adult; D000541:Alveolectomy / Q000379:methods; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016556:Crown Lengthening; D051546:Cyclooxygenase 2 / Q000187:drug effects; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D016854:Dental Anxiety / Q000523:psychology; D003774:Dental Plaque Index; D003907:Dexamethasone / Q000627:therapeutic use; D004008:Diclofenac / Q000031:analogs & derivatives / Q000627:therapeutic use; D004311:Double-Blind Method; D004487:Edema / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control; D010510:Periodontal Diseases / Q000601:surgery; D010512:Periodontal Index; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D013357:Subgingival Curettage / Q000379:methods; D013524:Surgical Flaps / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D005938:Glucocorticoids; D004008:Diclofenac; D003907:Dexamethasone; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; C473384:lumiracoxib