title: Anaphylaxis to ibuprofen in a 12-year-old boy.
abstract: Non-steroidal anti-inflammatory (NSAIDs) drugs are a group of medications acting through cyclooxygenase  (COX-1) and cyclooxygenase  (COX-2) enzymes inhibition. Hypersensitivity reactions to NSAIDs, although not rare, are poorly characterised and often go undiagnosed especially in children. We present in this paper a case of ibuprofen anaphylaxis that exemplifies the challenges involved in diagnosis and management of hypersensitivity reactions to NSAIDs.
authors: Department of Paediatrics,  Montreal Children's Hospital, McGill University Health Center, Montreal, Quebec,  Canada.
authors: Emily
authors: E
authors: Kay
authors: Moshe
authors: M
authors: Ben-Shoshan
mesh_terms: D000707:Anaphylaxis / Q000175:diagnosis / Q000209:etiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D003937:Diagnosis, Differential; D006261:Headache / Q000188:drug therapy; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen