title: [Preparation and pharmacokinetics of brucine hydrogel patch].
abstract: OBJECTIVE
  To investigate the effect of dose on pharmacokinetic properties of brucine hydrogel patch.
  
  
  METHODS
  The plasma concentration of brucine was determined by HPLC. Brucine hydrogel patch was prepared and its pharmaceutical characterization was investigated. After transdermal administration of different dose brucine hydrogel patch; Plasma concentration versus time profiles were determined and pharmacokinetic parameters were calculated by DAS program.
  
  
  RESULTS
  The pharmaceutical properties of brucine hydrogel patch were satisfactory. The AUC0-1 values were 7.24 +/- 0.61, 16.02 +/- 2.34 and 54.84 +/- 26.59 microg x h/mL after administration of 30, 60 and 180 mg/kg brucine hydrogel patch, respectively. The corresponding C(max) values were 0.73 +/- 0.23, 1.45 +/- 0.28 and 4.59 +/- 1.85 microg/mL, respectively. And the corresponding T(max) values were 8.67 +/- 2.07, 11.67 +/- 2.66 and 8.33 +/- 2.65 h, respectively.
  
  
  CONCLUSIONS
  The pharmacokinetic properties of brucine do not vary with the dose of brucine hydrogel patch.
authors: College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors: Jun
authors: J
authors: Chen
authors: Lei
authors: L
authors: Li
authors: Yan
authors: Y
authors: Qi
authors: Zhi-Peng
authors: ZP
authors: Chen
authors: Bao-Chang
authors: BC
authors: Cai
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005260:Female; D020100:Hydrogels / Q000008:administration & dosage*; D008297:Male; D011205:Povidone / Q000008:administration & dosage; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013331:Strychnine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D031461:Strychnos nux-vomica / Q000737:chemistry; D057968:Transdermal Patch
chemical_list: D020100:Hydrogels; C083806:brucine; D011205:Povidone; D013331:Strychnine; D002266:Carboxymethylcellulose Sodium