title: Iron nanoparticles from animal blood for cellular imaging and targeted delivery for cancer treatment.
abstract: BACKGROUND
  Iron nanoparticles (INPs) are usually prepared from inorganic sources, but we have prepared it from goat blood using incineration method. These INPs are then coated with chitosan (C) and coupled with folic acid (F) to form bionanocomposite for folate receptors.
  
  
  METHODS
  The bionanocomposite was characterized for its physicochemical properties and cancer cell targeting studies using Fourier transform infrared spectroscopy, transmission electron microscopy, Zeta potential analysis, scanning electron microscopy-energy dispersive X-ray spectroscopy and magnetic resonance imaging analyses.
  
  
  RESULTS
  The results have shown that the particle size of the INP-CF was found to be 80-300nm and confirmed the presence of chitosan and folic acid in the bionanocomposite. Cancer and normal mouse embryonic cell line study confirmed the internalization of INP-CF and this phenomenon was also supported by physicochemical studies.
  
  
  CONCLUSIONS
  Thus, nanobiocomposite prepared using natural sources as a raw material will be beneficial compared to commercially available synthetic sources and can be used as receptor targeting agent for cancer treatment. This nanobiocomposite when coupled with substances such as monoclonal antibodies might act as a theranostic nanoagent for cancer therapy in the years to come.
  
  
  CONCLUSIONS
  The prepared novel nanobiocomposite containing INPs isolated from natural source may be used as multifunctional agent due its paramagnetic property apart from its drug delivery effect.
authors: St. Joseph's College of Engg, Sholinganallur, Chennai-600 119, India. chamundeeswari@gmail.com
authors: M
authors: M
authors: Chamundeeswari
authors: T P
authors: TP
authors: Sastry
authors: B S
authors: BS
authors: Lakhsmi
authors: V
authors: V
authors: Senthil
authors: Enzo
authors: E
authors: Agostinelli
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D048271:Chitosan / Q000008:administration & dosage; D016503:Drug Delivery Systems; D005492:Folic Acid / Q000008:administration & dosage; D006041:Goats; D006801:Humans; D007501:Iron / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000008:administration & dosage*; D051379:Mice; D008858:Microscopy, Phase-Contrast; D041681:NIH 3T3 Cells; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000970:Antineoplastic Agents; D048271:Chitosan; D005492:Folic Acid; D007501:Iron