title: Using microPET imaging in quantitative verification of the acupuncture effect in ischemia stroke treatment.
abstract: Acupuncture has been indispensable in Chinese medicine. However, its function still remains elusive. This paper studies the effect of acupuncture in ischemia stroke treatment using the Sprague Dawley rat animal model. We induced focal cerebral ischemia in rats using the middle cerebral artery occlusion (MCAO) procedure. For each rat in the real acupuncture group (n = 63), the sham acupoint treatment group (n = 62), and the blank control group (n = 30), we acquired 3-D fluorodeoxyglucose-microPET images at baseline, after MCAO, and after treatment, respectively. Then, we measured the changes of the injury-volume in the right hemisphere of these rats. The measurements showed that real acupuncture slightly reduced the injury-volume, sham acupoint treatment increased the injury-volume, and blank control had no obvious effect in reducing the injury-volume. Statistical tests also confirmed that acupuncture was more effective than random stimulus in improving the metabolic recovery after stroke.
authors: State Key Laboratory of Modern Optical Instrumentation, Department of Optical Engineering, Zhejiang University, Hangzhou, Zhejiang, China.
authors: Huafeng
authors: H
authors: Liu
authors: Xiaoyan
authors: X
authors: Shen
authors: Hongtu
authors: H
authors: Tang
authors: Jia
authors: J
authors: Li
authors: Ting
authors: T
authors: Xiang
authors: Weichuan
authors: W
authors: Yu
mesh_terms: D015670:Acupuncture Therapy; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000737:chemistry; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000628:therapy*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18