title: Intraoperative electron beam radiotherapy for primary treatment of stage IIB cervical cancer: a retrospective study.
abstract: OBJECTIVE
  A retrospective study to evaluate intraoperative electron beam radiotherapy (IOERT) as a primary treatment modality for stage IIB cervical squamous cell carcinoma.
  
  
  METHODS
  Patients underwent treatment with IOERT (n = 78) or radical radiotherapy (RT; n = 89). Patients in the IOERT group received 20 Gy external beam radiotherapy (EBRT) in 10 fractions, intracavitary brachytherapy (7-14 Gy, in patients with tumours ≥ 4 cm in diameter) and simple hysterectomy/selective lymphadenectomy with 18 - 20 Gy IOERT. Patients in the RT group received 50 Gy EBRT in 25 fractions followed by intracavitary brachytherapy (35-40 Gy).
  
  
  RESULTS
  Median duration of follow-up was 92 months. IOERT resulted in significantly better 5- and 10-year overall survival, disease-free survival and local control rates, as well as fewer rectal and bladder complications, compared with RT.
  
  
  CONCLUSIONS
  IOERT is an effective primary treatment for stage IIB cervical squamous cell carcinoma.
authors: Department of Radiation Oncology, First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, China. liuzmail@163.com
authors: Z
authors: Z
authors: Liu
authors: Y
authors: Y
authors: Gao
authors: Y L
authors: YL
authors: Soong
authors: X
authors: X
authors: Chen
authors: F
authors: F
authors: Gao
authors: W
authors: W
authors: Luo
authors: W
authors: W
authors: Sheng
authors: J
authors: J
authors: Ren
authors: L
authors: L
authors: Zhang
authors: J
authors: J
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects; D007432:Intraoperative Period; D008197:Lymph Node Excision; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D055815:Young Adult