title: The treatment effect of diazoxide on 44 patients with congenital hyperinsulinism.
abstract: OBJECTIVE
  To study the treatment effect and safety of diazoxide on patients with congenital hyperinsulinism (CHI).
  
  
  METHODS
  A total of 44 patients who have been hospitalized to our hospital and used diazoxide as a trial after diagnosis of CHI were chosen as research subjects. The clinical data of the patients were analyzed, and the treatment effects and safety of diazoxide on CHI were evaluated.
  
  
  RESULTS
  In the 44 patients studied, the blood glucoses of 36 cases recovered to normal level after using diazoxide, indicating that the 36 patients respond to the treatment of diazoxide. Eight cases still showed severe hypoglycemia after using diazoxide for 10 days, which indicated that the eight patients were unresponsive to diazoxide treatment. Eighteen patients suffered the side effect of fluid retention, and 12 patients suffered transient gastrointestinal reactions.
  
  
  CONCLUSIONS
  Diazoxide is a first-line treatment of CHI with high safety. Most of the patients with CHI were responsive to diazoxide treatment. Diazoxide should be used as a trial immediately after CHI diagnosis was made.
authors: National Key Discipline of Pediatrics, Capital Medical University, Ministry of Education, Endocrine and Genetic Metabolic Center, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.
authors: Shuwen
authors: S
authors: Hu
authors: Zidi
authors: Z
authors: Xu
authors: Jie
authors: J
authors: Yan
authors: Min
authors: M
authors: Liu
authors: Bing
authors: B
authors: Sun
authors: Wenjing
authors: W
authors: Li
authors: Yanmei
authors: Y
authors: Sang
mesh_terms: D017668:Age of Onset; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D002681:China / Q000453:epidemiology; D044903:Congenital Hyperinsulinism / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D003981:Diazoxide / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D001786:Blood Glucose; D003981:Diazoxide