title: Acupuncture for the treatment of post-chemotherapy chronic fatigue: a randomized, blinded, sham-controlled trial.
abstract: OBJECTIVE
  Many cancer patients experience persistent fatigue after the completion of chemotherapy. A previous single-arm study provided evidence for an effect of acupuncture in this population. We conducted a randomized controlled trial to determine whether acupuncture reduces post-chemotherapy chronic fatigue more effectively than sham acupuncture.
  
  
  METHODS
  Cancer patients reporting significant fatigue persisting for at least 2 months following the completion of chemotherapy were randomized to receive once weekly true or sham acupuncture for 6 weeks. Fatigue was evaluated before and after treatment using the Brief Fatigue Inventory (BFI, the primary endpoint). Secondary endpoints included the Hospital Anxiety and Depression Scale (HADS) and Functional Assessment of Cancer Treatment-General (FACT-G) scores.
  
  
  RESULTS
  One hundred one patients were randomized with 74 (34 true acupuncture; 40 sham control) evaluated for the primary endpoint. BFI scores fell by about one point between baseline and follow-up in both groups with no statistically significant difference between groups. HADS and FACT-G scores also improved in both groups, but there was no significant difference between groups. Patients in the sham acupuncture group crossed over to receive true acupuncture in week 7. No long-term reduction of fatigue scores was observed at the 6-month evaluation.
  
  
  CONCLUSIONS
  True acupuncture as provided in this study did not reduce post-chemotherapy chronic fatigue more than did sham acupuncture. The study is limited by the number of patients lost to follow-up. We also cannot exclude the possibility that a more intensive treatment regimen may be more effective.
authors: Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, 1429 First Avenue, New York, NY 10021, USA. dengg@mskcc.org
authors: Gary
authors: G
authors: Deng
authors: Yi
authors: Y
authors: Chan
authors: Daniel
authors: D
authors: Sjoberg
authors: Andrew
authors: A
authors: Vickers
authors: K Simon
authors: KS
authors: Yeung
authors: Mark
authors: M
authors: Kris
authors: David
authors: D
authors: Straus
authors: Barrie
authors: B
authors: Cassileth
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods*; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002908:Chronic Disease; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005221:Fatigue / Q000139:chemically induced / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000188:drug therapy; D019337:Hematologic Neoplasms / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D013736:Testicular Neoplasms / Q000188:drug therapy; D017211:Treatment Failure
chemical_list: D000970:Antineoplastic Agents