title: A case of lambert-eaton myasthenic syndrome with small-cell lung cancer and transient increase in anti-acetylcholine-receptor-binding antibody titer.
abstract: BACKGROUND
  Lambert-Eaton myasthenic syndrome (LEMS) is a presynaptic neuromuscular junction disorder that is most frequently associated with small-cell lung cancer (SCLC). The titers of antibodies against voltage-gated calcium channels are frequently increased in LEMS, but only rarely is titer of anti-acetylcholine-receptor-binding antibodies (AChR-abs) increased.
  
  
  METHODS
  A 57-year-old male was admitted to our hospital due to dry mouth and eyes and progressive proximal limb weakness of 2 months duration. The results of a repetitive nerve stimulation test disclosed all criteria for the electrophysiological LEMS pattern, and the patient's AChR-abs titer was 0.587 nmol/L. At a follow-up performed 5 years after successful treatment of SCLC and LEMS, his AChR-abs titer had decreased to 0.001 nmol/L.
  
  
  CONCLUSIONS
  We suggest that this was a case of transient pseudopositivity of AChR-abs in SCLC with LEMS.
authors: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. ; Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
authors: Jung Hwan
authors: JH
authors: Lee
authors: Ha Young
authors: HY
authors: Shin
authors: Seung Min
authors: SM
authors: Kim
authors: Il Nam
authors: IN
authors: Sunwoo
keywords: Lambert-Eaton myasthenic syndrome; myasthenia gravis; small-cell lung carcinoma