title: Antibacterial and antiplasmodial constituents of Beilschmiedia cryptocaryoides.
abstract: Four new beilschmiedic acid derivatives, cryptobeilic acids A-D (1-4), and tsangibeilin B (5) have been isolated from the bark of Beilschmiedia cryptocaryoides collected from Madagascar. Their structures were elucidated using detailed spectroscopic and spectrometric methods. Cryptobeilic acid A (1) and tsangibeilin B (5) structures were confirmed by single-crystal X-ray diffraction analysis. Compounds 1-5 displayed moderate antibacterial activity against Escherichia coli 6r3, Acinetobacter calcoaceticus DSM 586, and Pseudonamas stutzeri A1501, with the minimum inhibitory concentrations ranging from 10 to 50 μM, respectively. In addition, the compounds exhibited antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum strain NF54 and weak cytotoxicity against L6 cell lines.
authors: Institute of Environmental Research (INFU) of the Faculty of Chemistry, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Strasse 6, D-44221 Dortmund, Germany.
authors: Ferdinand Mouafo
authors: FM
authors: Talontsi
authors: Marc
authors: M
authors: Lamshöft
authors: Jonathan O
authors: JO
authors: Bauer
authors: Andrianambinina A
authors: AA
authors: Razakarivony
authors: Bakoli
authors: B
authors: Andriamihaja
authors: Carsten
authors: C
authors: Strohmann
authors: Michael
authors: M
authors: Spiteller
mesh_terms: D016954:Acinetobacter calcoaceticus / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002738:Chloroquine / Q000097:blood / Q000494:pharmacology; D004351:Drug Resistance / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D019770:Lauraceae / Q000737:chemistry; D008270:Madagascar; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D044223:Pseudomonas stutzeri / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D002738:Chloroquine