title: Can nail, hair and urine be used for biomonitoring of human exposure to perfluorooctane sulfonate and perfluorooctanoic acid?
abstract: Because of the disadvantages of invasive sampling, it is desirable to explore non-invasive matrices for human biomonitoring of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). The aim of this study was to evaluate the application of nail, hair and urine for human biomonitoring of PFOS and PFOA. The concentrations of PFOS and PFOA in matched nail, hair, urine and serum samples collected from 64 donors were measured. The chemicals of interest were detected with high detection frequency in these matrices (90%-100%) except for PFOA in urine samples (56%). Generally, the gender influences on the levels of PFOS and PFOA in these non-invasive matrices were in agreement with that in serum. For PFOS, the coefficients of Spearman correlation between serum samples and nail, hair and urine samples were 0.786 (p<0.001), 0.545 (p<0.001) and 0.302 (p<0.05), respectively. For PFOA, the correlation was only observed between nail samples and serum samples with a correlation coefficient of 0.299 (p<0.05). The results suggested that nail has more potential than hair and urine to be applied in human biomonitoring for PFOS and PFOA in general populations.
authors: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety and Risk Assessment, Beijing 100021, China.
authors: Jingguang
authors: J
authors: Li
authors: Feifei
authors: F
authors: Guo
authors: Yuxin
authors: Y
authors: Wang
authors: Jialing
authors: J
authors: Zhang
authors: Yuxin
authors: Y
authors: Zhong
authors: Yunfeng
authors: Y
authors: Zhao
authors: Yongning
authors: Y
authors: Wu
mesh_terms: D000328:Adult; D017738:Alkanesulfonic Acids / Q000097:blood / Q000378:metabolism* / Q000652:urine; D002210:Caprylates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004781:Environmental Exposure / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D005466:Fluorocarbons / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006197:Hair / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009262:Nails / Q000378:metabolism*; D044967:Serum / Q000378:metabolism; D055815:Young Adult
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D005466:Fluorocarbons; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid