title: Correlation between intereye difference in visual field mean deviation values and relative afferent pupillary response as measured by an automated pupillometer in subjects with glaucoma.
abstract: OBJECTIVE
  To evaluate the effectiveness of a new binocular infrared computerized pupillometer in the quantitative measurement of the relative afferent pupillary response in patients with glaucoma by assessing the correlation of the intereye difference in visual function as measured by standard automated perimetry (SAP) with the intereye difference in the afferent pupillary response.
  
  
  METHODS
  Twenty-three patients with glaucoma underwent examination with a prototype, automated, binocular pupillometer. Correlation between the intereye difference in the afferent pupillary response and the intereye difference in mean deviation (MD) was explored.
  
  
  RESULTS
  Within 7 months of pupillography, all patients underwent SAP using the Humphrey Field Analyzer IIi, 24-2, Swedish Interactive Threshold Algorithm. The intereye differential pupillary response was 0.69±0.59 (log units, mean±SD). The intereye difference in MD was 5.67±5.29 dB (mean±SD). There was a strong correlation between the intereye difference in the afferent pupillary response and the intereye difference in MD (Spearman correlation coefficient, r = -0.77; P<0.001).
  
  
  CONCLUSIONS
  A new, binocular computerized pupillometer provides an automated method for the quantitative assessment of the afferent pupillary response. The intereye asymmetry in the pupil response correlates strongly with asymmetry in visual function, as measured by SAP, in patients with glaucoma.
authors: *Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL †Konan Medical USA, Irvine, CA.
authors: Daniel
authors: D
authors: Sarezky
authors: Theodore
authors: T
authors: Krupin
authors: Aaron
authors: A
authors: Cohen
authors: Charles Wm
authors: CW
authors: Stewart
authors: Nicholas J
authors: NJ
authors: Volpe
authors: Angelo P
authors: AP
authors: Tanna
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003623:Dark Adaptation; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation*; D005260:Female; D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011680:Pupil / Q000502:physiology*; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*