title: Distinct pathways for rule-based retrieval and spatial mapping of memory representations in hippocampal neurons.
abstract: Hippocampal neurons encode events within the context in which they occurred, a fundamental feature of episodic memory. Here we explored the sources of event and context information represented by hippocampal neurons during the retrieval of object associations in rats. Temporary inactivation of the medial prefrontal cortex differentially reduced the selectivity of rule-based object associations represented by hippocampal neuronal firing patterns but did not affect spatial firing patterns. In contrast, inactivation of the medial entorhinal cortex resulted in a pervasive reorganization of hippocampal mappings of spatial context and events. These results suggest distinct and cooperative prefrontal and medial temporal mechanisms in memory representation.
authors: Center of Memory and Brain, Boston University, Boston, Massachusetts 02115, USA.
authors: Rapeechai
authors: R
authors: Navawongse
authors: Howard
authors: H
authors: Eichenbaum
mesh_terms: D000818:Animals; D001245:Association Learning / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D013028:Space Perception / Q000502:physiology