title: Monocyclic β-lactams as antibacterial agents: facing antioxidant activity of N-methylthio-azetidinones.
abstract: A series of N-methylthio-β-lactams with antibacterial activity were thoroughly evaluated as antioxidants. We found that only the presence of a polyphenolic moiety anchored to the β-lactam ring ensured an adequate antioxidant potency. New compounds, efficiently combining in one structure antioxidant and antibacterial activity, may provide a promising basis for the development of new leads useful in adverse clinical conditions such as in cystic fibrosis patients, in whom colonization by MRSA and epithelial damage by chronic pulmonary oxidative stress take place.
authors: Department of Chemistry G. Ciamician, University of Bologna, Via Selmi 2, 40126 Bologna, Italy. rinaldo.cervellati@unibo.it
authors: Rinaldo
authors: R
authors: Cervellati
authors: Paola
authors: P
authors: Galletti
authors: Emanuela
authors: E
authors: Greco
authors: Clementina E A
authors: CE
authors: Cocuzza
authors: Rosario
authors: R
authors: Musumeci
authors: Luca
authors: L
authors: Bardini
authors: Francesco
authors: F
authors: Paolucci
authors: Matteo
authors: M
authors: Pori
authors: Roberto
authors: R
authors: Soldati
authors: Daria
authors: D
authors: Giacomini
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003550:Cystic Fibrosis / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D008997:Monobactams / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001384:Azetidines; D008997:Monobactams; D013440:Sulfides