title: Single-molecule DNA detection using a novel SP1 protein nanopore.
abstract: SP1 protein as a new type of biological nanopore is described and is utilized to distinguish single-stranded DNA at the single-molecule level. Using the SP1 nanopore to investigate single molecule detection broadens the existing research areas of pore-forming biomaterials from unsymmetrical biological nanopores to symmetrical biological nanopores. This novel nanopore could provide a good candidate for single-molecule detection and characterization of biomaterial applications.
authors: Key Laboratory for Advanced Materials and Institute of Fine Chemicals & Department of Chemistry, East China University of Science and Technology Shanghai, PR China.
authors: Hai-Yan
authors: HY
authors: Wang
authors: Yang
authors: Y
authors: Li
authors: Li-Xia
authors: LX
authors: Qin
authors: Arnon
authors: A
authors: Heyman
authors: Oded
authors: O
authors: Shoseyov
authors: Itamar
authors: I
authors: Willner
authors: Yi-Tao
authors: YT
authors: Long
authors: He
authors: H
authors: Tian
mesh_terms: D004277:DNA, Single-Stranded / Q000032:analysis*; D055664:Electrochemical Techniques; D006460:Hemolysin Proteins / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008051:Lipid Bilayers / Q000737:chemistry; D058608:Nanopores; D011506:Proteins / Q000737:chemistry*
chemical_list: D004277:DNA, Single-Stranded; D006460:Hemolysin Proteins; D008051:Lipid Bilayers; D011506:Proteins