title: Expression of HMGB1 and its clinical significance in T-cell lymphoma.
abstract: OBJECTIVE
  To evaluate the clinical significance of HMGB1 expression in T-cell lymphoma.
  
  
  METHODS
  Immunohistochemical staining for HMGB1 and survivin was performed with specimens from 120 cases of T-cell lymphoma and 40 cases of reactive lymphoid hyperplasia with antibodies against human HMGB1 and survivin.
  
  
  RESULTS
  The expression of HMGB1 and survivin was significantly higher in tissues of T-cell lymphoma than in reactive lymphoid hyperplasia. Positive expression of HMGB1 and survivin was observed in 63.7% (65/102) and 61.8% (63/102) of T-cell lymphoma cases, respectively. While was associated with gender, age, and tumor location, significant correlations with malignancy and clinical stage were observed. Spearman rank correlation analysis revealed that the expression of HMGB1 and survivin was positively correlated in T-cell lymphomas (P<0.01).
  
  
  CONCLUSIONS
  Expression of HMGB1 and survivin in T-cell lymphomas is significantly associated with malignancy and clinical stage, but not with gender, age and tumor location. Elevated expression of HMGB1 may be an important biomarker for the development and progression of T-cell lymphoma.
authors: Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China. xingjiangmaocn@163.com
authors: Xing-Jiang
authors: XJ
authors: Mao
authors: Geng-Fu
authors: GF
authors: Wang
authors: Zhi-Jun
authors: ZJ
authors: Chen
authors: Li-Na
authors: LN
authors: Wang
authors: Jun-Biao
authors: JB
authors: Zhang
authors: Hui-Ling
authors: HL
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D024243:HMGB1 Protein / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D016399:Lymphoma, T-Cell / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D019310:Pseudolymphoma / Q000378:metabolism* / Q000473:pathology; D000077022:Survivin; D055815:Young Adult
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D024243:HMGB1 Protein; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin