title: Clinical value of immunoscintigraphy in the rectal carcinomas: immunoscintigraphy of rectal carcinomas.
abstract: OBJECTIVE
  The aim of this study was to evaluate the clinical reliability of the immunoscintigraphy with radiolabeled monoclonal antibodies for the detection of metastases and recurrences of rectal carcinomas.
  
  
  METHODS
  A total of 65 patients underwent immunoscintigraphy with radiolabeled monoclonal antibodies. Indication for that examination was suspicious rectal cancer or suspicious rectal cancer recurrence and/or metastases.
  
  
  RESULTS
  The method proved to have 92.7% sensitivity, specificity 83.3%, positive predictive value 90.5%, negative predictive value 87.0% and accuracy 89.2%. There was a statistically significant relationship between immunoscintigraphy findings and rectoscopy findings (rs=0.415, p=0.013), as well as significant relationship between immunoscintigraphy findings and US findings (rs=0.332, p=0.001). Tumor marker levels were in positive correlation with findings of immunoscintigraphy (rs=0.845, p=0.001), especially raised CEA level (rs=0.816, p=0.004). Patients with higher CA19-9 level had higher Duke's stage (p=0.025).
  
  
  CONCLUSIONS
  We can conclude that immunoscintigraphy can be helpful in the detection of metastases and recurrences of colon carcinomas.
authors: Milorad
authors: M
authors: Petrovic
authors: Z
authors: Z
authors: Jankovic
authors: Lj
authors: Lj
authors: Jaukovic
authors: Vera
authors: V
authors: Artiko
authors: Dragana
authors: D
authors: Šobic-Šaranovic
authors: Andrija
authors: A
authors: Antic
authors: Marinko
authors: M
authors: Žuvela
authors: Nebojsa
authors: N
authors: Radovanovic
authors: Ivan
authors: I
authors: Palibrk
authors: Danijel
authors: D
authors: Galun
authors: Slavko
authors: S
authors: Matic
authors: Zlatibor
authors: Z
authors: Loncar
authors: Predrag
authors: P
authors: Bojovic
authors: Boris
authors: B
authors: Ajdinovic
authors: Vladimir
authors: V
authors: Obradovic
mesh_terms: D000328:Adult; D000368:Aged; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D016719:Radioimmunodetection; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen