title: Psychiatric symptoms in adults with phenylketonuria.
abstract: BACKGROUND
  The objective of this study was to identify psychiatric symptom patterns reported by individuals with phenylketonuria (PKU) in the outpatient clinic setting.
  
  
  METHODS
  Brief Symptom Inventory (BSI) results, phenylalanine (phe) levels, and demographic information were collected through a retrospective chart review on 64 participants in the study, "A Diversified Approach for PKU Treatment" (ADAPT).
  
  
  RESULTS
  The number of BSI scores meeting clinical threshold was significantly elevated for all global indexes and 6 out of 7 symptom subscales in patients with PKU. Recent and mean phe levels were correlated with age at the time of screening (R(2)=0.10, R(2)=0.10, respectively; p<0.05). Psychoticism and the Positive Symptom Distress Index (PSDI) scores were associated with metabolic control.
  
  
  CONCLUSIONS
  The results of this study demonstrate a positive correlation between phe levels and psychiatric symptom severity in individuals with PKU.
authors: Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA. deborah.bilder@hsc.utah.edu
authors: Deborah A
authors: DA
authors: Bilder
authors: Barbara K
authors: BK
authors: Burton
authors: Hilary
authors: H
authors: Coon
authors: Lauren
authors: L
authors: Leviton
authors: James
authors: J
authors: Ashworth
authors: Bridget D
authors: BD
authors: Lundy
authors: Hazel
authors: H
authors: Vespa
authors: Amanda V
authors: AV
authors: Bakian
authors: Nicola
authors: N
authors: Longo
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010649:Phenylalanine / Q000097:blood*; D010661:Phenylketonurias / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D011618:Psychotic Disorders / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D012107:Research Design; D012189:Retrospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D010649:Phenylalanine