title: Maternal antihypertensive drugs may influence cerebral oxygen extraction in preterm infants during the first days after birth.
abstract: OBJECTIVE
  To determine whether maternal antihypertensive drugs influenced cerebral oxygenation in preterm infants during the first days after birth.
  
  
  METHODS
  We included 49 preterm infants (median gestational age 30.3 weeks, (range 26.0-31.9), birth weight 1250 g (560-2250)). Regional cerebral oxygen saturation (rcSO2) was measured by near-infrared spectroscopy on postnatal days 1, 2, 3, 4 and 5. Fractional tissue oxygen extraction (FTOE) was calculated using rcSO2 and arterial oxygen saturation (SpO2) values:(SpO2 - rcSO2)/SpO2.
  
  
  RESULTS
  Nine mothers were treated with labetalol and/or MgSO4 during pregnancy, three mothers with labetalol, MgSO4 and nifedipine, and 19 mothers with nifedipine only. Eighteen infants served as controls. Multivariate linear regression analysis showed that exposure to labetalol and/or MgSO4 during pregnancy decreased FTOE on day 1 after birth, while nifedipine did not.
  
  
  CONCLUSIONS
  Treating pregnant women with labetalol and/or MgSO4 may influence cerebral oxygen extraction in their offspring shortly after birth.
authors: Division of Neonatology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. e.a.verhagen@umcg.nl
authors: Elise A
authors: EA
authors: Verhagen
authors: Elisabeth M W
authors: EM
authors: Kooi
authors: Paul P
authors: PP
authors: van den Berg
authors: Arend F
authors: AF
authors: Bos
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D007741:Labetalol / Q000008:administration & dosage / Q000009:adverse effects*; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use; D010101:Oxygen Consumption / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000453:epidemiology / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D008278:Magnesium Sulfate; D009543:Nifedipine; D007741:Labetalol