title: Prospective analysis of 44 consecutive liver transplants performed at a university hospital.
abstract: OBJECTIVE
  To analyze the intraoperative and immediate postoperative biochemical parameters of patients submitted to orthotopic liver transplantation.
  
  
  METHODS
  Forty four consecutive orthotopic liver transplants performed from October 2009 to December 2010 were analyzed. The patients (38 male and eight female) were divided into two groups: group A, survivors, and group B, non-survivors. Fifty percent of group A patients were Chid-Pugh C, 40% Chid-Pugh B and 10% Chid-Pugh A. In group B, 52% of the patients were Chid-Pugh C, 41% Chid-Pugh B, and 17% Chid-Pugh A. All orthotopic liver transplants were performed by the piggy-back technique without a portacaval shunt in an anhepatic phase. ALT, AST, LDH and lactate levels were determined preoperatively, at five, 60 minutes after arterial revascularization of the graft and 24 and 48 hours after the end of the surgery.( or: after the surgery was finished).
  
  
  RESULTS
  There were no preoperative clinical differences (Child and Meld) between the two groups. The times of warm and hypothermal ischemia were similar for both groups (p>0.05). Serum aminotransferases levels at five and 60 minutes after arterial revascularization of the graft were similar (p>0.05) for both groups, as also were lactate levels at the time points studied. There was no significant difference in Δ lactate between groups at any time point studied (p>0.05). No significant difference was observed between groups during the first 24 and 48 hours after surgery (p>0.05).
  
  
  CONCLUSIONS
  No significant difference in any of the parameters studied was observed between groups. Under the conditions of the present study and considering the parameters evaluated, no direct relationship was detected between the intraoperative situation and the type of evolution of the patients of the two groups studied.
authors: Department of Surgery and Anatomy, FMRP, USP, Ribeirao Preto, SP, Brazil. orlando@fmrp.usp.br
authors: Orlando Castro e
authors: OC
authors: Silva
authors: Priscila
authors: P
authors: Nejo
authors: Nathalia
authors: N
authors: Cardoso
authors: Enio David
authors: ED
authors: Mente
authors: Fernanda Fernandes
authors: FF
authors: Souza
authors: Andreza Corrêa
authors: AC
authors: Teixeira
authors: Thiago
authors: T
authors: Freitas
authors: Daniel
authors: D
authors: Cagnolati
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007432:Intraoperative Period; D007770:L-Lactate Dehydrogenase / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D008168:Lung / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D017678:Sex Distribution; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019344:Lactic Acid; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase