title: [Studies on sustained release solid dispersion of tripterine carried by HPMC-stearic acid].
abstract: OBJECTIVE
  To prepare the sustained release solid dispersion of tripterine, using HPMC-stearic acid with the intention of improving drug dissolution and controlling drug releases moderate, so that the drug performances lower toxicity.
  
  
  METHODS
  Tripterine sustained release solid dispersions was prepared by the solvent method with different weight ratios of HPMC-stearic acid and tripterine, which were dissolved in 95% ethanol. And in vitro dissolution experiment was conducted. Differential scanning calorimetry, scanning electron microscopy and X-ray powder diffraction can prove the formation of solid dispersions.
  
  
  RESULTS
  The ideal tripterine sustained release solid dispersions were prepared under the condition as follows, the weight ratio of tripterine and HPMC-stearic acid was 1: 10, and the release rate of drug can keep moderate and controllable. In vitro cumulative release of tripterine sustained release solid dispersion is up to more than 90% after 8 h, and the tripterine exist as amorphous in the solid dispersion.
  
  
  CONCLUSIONS
  The sustained release solid dispersion of tripterine, carried by HPMC-stearic acid, can improve the release of tripterine effectively and controls the release rate keep moderate and controllable, and the preparation process is simple, which has potential applications.
authors: Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. hsy872805820@163.com
authors: Shao-Ying
authors: SY
authors: Hu
authors: Zhen-Hai
authors: ZH
authors: Zhang
authors: Yan-Rong
authors: YR
authors: Jiang
authors: Qing
authors: Q
authors: Ning
authors: Qi-Yuan
authors: QY
authors: Liu
authors: Xiao-Bin
authors: XB
authors: Jia
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D007700:Kinetics; D053978:Pentacyclic Triterpenes; D013229:Stearic Acids / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D053978:Pentacyclic Triterpenes; D013229:Stearic Acids; D014315:Triterpenes; C031183:stearic acid; C050414:celastrol