title: Gold-mediated selective cysteine modification of peptides using allenes.
abstract: A new approach for selective modification of cysteine-containing peptides through gold-mediated oxidative allene-thiol coupling reaction in aqueous medium is developed.
authors: State Key Laboratory of Synthetic Chemistry, Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors: Anna On-Yee
authors: AO
authors: Chan
authors: Johnson Lui-Lui
authors: JL
authors: Tsai
authors: Vanessa Kar-Yan
authors: VK
authors: Lo
authors: Gai-Li
authors: GL
authors: Li
authors: Man-Kin
authors: MK
authors: Wong
authors: Chi-Ming
authors: CM
authors: Che
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism*; D006046:Gold / Q000737:chemistry*; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D012259:Ribonuclease, Pancreatic / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D000466:Alkadienes; D010455:Peptides; D013438:Sulfhydryl Compounds; C025947:propadiene; D006046:Gold; D012259:Ribonuclease, Pancreatic; D003545:Cysteine