title: Polyflavanostilbene A, a new flavanol-fused stilbene glycoside from Polygonum cuspidatum.
abstract: Polyflavanostilbene A, a new flavanol-fused stilbene glycoside, was isolated from the rhizome of Polygonum cuspidatum. Its unusual structure, including its absolute stereochemistry, was determined by UV, IR, HRESIMS, and 1D and 2D NMR data and by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Polyflavanostilbene A has an unprecedented rearranged flavanol skeleton fused to stilbene via a hexahydrocyclopenta[c]furan moiety. Polyflavanostilbene A showed strong inhibitory activity against α-glucosidase with an IC(50) value of 17.7 μM.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China.
authors: Fushuang
authors: F
authors: Li
authors: Zhilai
authors: Z
authors: Zhan
authors: Fu
authors: F
authors: Liu
authors: Yanan
authors: Y
authors: Yang
authors: Li
authors: L
authors: Li
authors: Ziming
authors: Z
authors: Feng
authors: Jianshuang
authors: J
authors: Jiang
authors: Peicheng
authors: P
authors: Zhang
mesh_terms: D045468:Fallopia japonica / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D059808:Polyphenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; D059808:Polyphenols; D013267:Stilbenes; C581427:polyflavanostilbene A