title: High-sensitivity cardiac troponin T levels are increased in stable COPD.
abstract: OBJECTIVE
  To assess the distribution of high-sensitivity cardiac troponin T (hs-cTnT) concentrations in stable chronic obstructive pulmonary disease (COPD), and whether hs-cTnT is associated with pulmonary function.
  
  
  METHODS
  Prospectively designed, cross-sectional study.
  
  
  METHODS
  Outpatient clinic of Norwegian teaching hospital and community-based setting.
  
  
  METHODS
  Sample of 101 stable COPD patients from the hospital's outpatient clinic and 120 individuals derived from a random general population sample.
  
  
  RESULTS
  Ratio of hs-cTnT in stable COPD patients compared with references from the general population. Change in ratio of hs-cTnT per unit increase of relevant covariables.
  
  
  RESULTS
  The crude geometric means of circulating hs-cTnT in the cases and the references were 7.75 and 3.01 ng/l, respectively (p < 0.001); that is, a relative ratio of 2.57 (95% CI 2.05 to 3.23). After adjustment for relevant confounders, this ratio was moderately attenuated to 1.65 (1.31-2.08). In the total study cohort, as well as among stable COPD patients, we found a significant positive association between hs-cTnT and interleukin-6 concentrations (p < 0.001) and the presence of pathologic Q waves (p = 0.023). Among stable COPD patients, one quartile increase in forced expiratory volume 1 was associated with a 39% decrease in hs-cTnT and patient category (Global Initiative of Obstructive Lung Disease classification 2011) was positively associated with hs-cTnT (p trend < 0.001) after multivariate adjustment.
  
  
  CONCLUSIONS
  Stable COPD is independently associated with higher hs-cTnT compared with randomly drawn subjects from the general population. In patients with stable COPD, higher hs-cTnT seems to be associated with immune activation and the severity of the disease.
authors: Department of Cardiology, Division of Medicine, Akershus University Hospital, Sykehusveien 27, Lørenskog 1478, Norway. torbjorn.omland@medisin.uio.no
authors: Anke M C
authors: AM
authors: Neukamm
authors: Arne Didrik
authors: AD
authors: Høiseth
authors: Tor-Arne
authors: TA
authors: Hagve
authors: Vidar
authors: V
authors: Søyseth
authors: Torbjørn
authors: T
authors: Omland
mesh_terms: D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D009664:Norway / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012720:Severity of Illness Index; D015996:Survival Rate / Q000639:trends; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T