title: Maternal micronutrients and omega 3 fatty acids affect placental fatty acid desaturases and transport proteins in Wistar rats.
abstract: Adequate supply of LCPUFA from maternal plasma is crucial for fetal normal growth and development. The present study examines the effect of maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids on placental mRNA levels of fatty acid desaturases (Δ5 and Δ6) and transport proteins. Pregnant female rats were divided into 6 groups at 2 levels of folic acid both in the presence and absence of vitamin B12. Both the vitamin B12 deficient groups were supplemented with omega 3 fatty acid. Maternal vitamin B12 deficiency reduced placental mRNA and protein levels of Δ5 desaturase, mRNA levels of FATP1 and FATP4 (p<0.05 for all) as compared to control while omega 3 fatty acid supplementation normalized the levels. Our data for the first time indicates that altered maternal micronutrients and omega 3 fatty acids play a key role in regulating fatty acid desaturase and transport protein expression in placenta.
authors: Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India.
authors: Nisha S
authors: NS
authors: Wadhwani
authors: Kamini D
authors: KD
authors: Dangat
authors: Asmita A
authors: AA
authors: Joshi
authors: Sadhana R
authors: SR
authors: Joshi
mesh_terms: D000818:Animals; D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases / Q000235:genetics / Q000378:metabolism; D050612:Fatty Acid Transport Proteins / Q000235:genetics / Q000378:metabolism*; D050556:Fatty Acid-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage*; D015870:Gene Expression; D050602:Linoleoyl-CoA Desaturase / Q000235:genetics / Q000378:metabolism*; D018977:Micronutrients / Q000008:administration & dosage* / Q000172:deficiency; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014805:Vitamin B 12 / Q000008:administration & dosage*; D014806:Vitamin B 12 Deficiency
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; D050612:Fatty Acid Transport Proteins; D050556:Fatty Acid-Binding Proteins; D018977:Micronutrients; D012333:RNA, Messenger; C493570:Slc27a1 protein, rat; C542875:Slc27a4 protein, rat; D005492:Folic Acid; D044943:Fatty Acid Desaturases; D050602:Linoleoyl-CoA Desaturase; D014805:Vitamin B 12