title: Asymmetric direct α-alkylation of 2-oxindoles with Michler's hydrol catalyzed by bis-cinchona alkaloid-Brønsted acid via an SN1-type pathway.
abstract: An enantioselective direct α-alkylation of 2-oxindoles with Michler's hydrol via an S(N)1-type pathway in the non-covalent activation mode using the bis-cinchona alkaloid and Brønsted acid as a co-catalyst was developed and good to high yields and enantioselectivities were obtained.
authors: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors: Tao
authors: T
authors: Zhang
authors: Zhen
authors: Z
authors: Qiao
authors: Yan
authors: Y
authors: Wang
authors: Nengjun
authors: N
authors: Zhong
authors: Li
authors: L
authors: Liu
authors: Dong
authors: D
authors: Wang
authors: Yong-Jun
authors: YJ
authors: Chen
mesh_terms: D000143:Acids / Q000737:chemistry*; D000478:Alkylation; D000814:Aniline Compounds / Q000737:chemistry*; D001559:Benzhydryl Compounds / Q000737:chemistry*; D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D013237:Stereoisomerism
chemical_list: D000143:Acids; D000814:Aniline Compounds; D001559:Benzhydryl Compounds; D002930:Cinchona Alkaloids; D007211:Indoles; C558904:Michler's hydrol blue; D000078183:Oxindoles; C022960:2-oxindole