title: A pilot study of tandem high-dose chemotherapy with stem cell rescue as consolidation for high-risk neuroblastoma: Children's Oncology Group study ANBL00P1.
abstract: Increasing treatment intensity has improved outcomes for children with neuroblastoma. We performed a pilot study in the Children's Oncology Group to assess the feasibility and toxicity of a tandem myeloablative regimen without TBI supported by autologous CD34-selected peripheral blood stem cells. Forty-one patients with high-risk neuroblastoma were enrolled; eight patients did not receive any myeloablative consolidation procedure and seven received only one. Two patients out of 41 (4.9%) experienced transplant-related mortality. CD34 selection was discontinued after subjects were enrolled due to serious viral illness. From the time of study enrollment, the overall 3-year EFS and OS were 44.8 ± 9.6% and 59.2 ± 9.2% (N=41). These results demonstrate that tandem transplantation in the cooperative group setting is feasible and support a randomized comparison of single vs tandem myeloablative consolidation with PBSC support for high-risk neuroblastoma.
authors: Department of Pediatrics, Division of Oncology, The Children's Hospital of Philadelphia and Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA.
authors: A E
authors: AE
authors: Seif
authors: A
authors: A
authors: Naranjo
authors: D L
authors: DL
authors: Baker
authors: N J
authors: NJ
authors: Bunin
authors: M
authors: M
authors: Kletzel
authors: C S
authors: CS
authors: Kretschmar
authors: J M
authors: JM
authors: Maris
authors: P W
authors: PW
authors: McGrady
authors: D
authors: D
authors: von Allmen
authors: S L
authors: SL
authors: Cohn
authors: W B
authors: WB
authors: London
authors: J R
authors: JR
authors: Park
authors: L R
authors: LR
authors: Diller
authors: S A
authors: SA
authors: Grupp
mesh_terms: D064592:Autografts; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009447:Neuroblastoma / Q000401:mortality* / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D010865:Pilot Projects; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods*; D014777:Virus Diseases / Q000209:etiology / Q000401:mortality