title: Cerebral vasculitis and multi-focal neurological deficits due to allopurinol-induced hypersensitivity syndrome.
abstract: Drug-induced hypersensitivity syndrome (DIHS) is a multi-system syndrome resulting from an idiosyncratic reaction to medication. While it commonly results in multi-organ involvement, particularly the liver, there are few reports of DIHS causing cerebral vasculitis and neurological deficits. We report the case of a 63-year old woman with DIHS secondary to allopurinol leading to multiple neurological deficits with magnetic resonance imaging findings consistent with a cerebral vasculitis.
authors: Department of Dermatology, Waikato Hospital, Hamilton, Waikato, New Zealand.
authors: David
authors: D
authors: Lim
authors: Marius
authors: M
authors: Rademaker
authors: Fredrik
authors: F
authors: Asztely
authors: Manjula
authors: M
authors: Ratnaweera
authors: Glenn
authors: G
authors: Coltman
mesh_terms: D000493:Allopurinol / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000150:complications*; D005260:Female; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009460:Neurologic Examination; D020293:Vasculitis, Central Nervous System / Q000209:etiology*
chemical_list: D006074:Gout Suppressants; D000493:Allopurinol
keywords: adverse drug reaction; drug reaction with eosinophilia and systemic symptom; drug-induced hypersensitivity syndrome