title: A case of transfusion-related acute lung injury induced by anti-human leukocyte antigen antibodies in acute leukemia.
abstract: Transfusion-related acute lung injury (TRALI) is a noncardiogenic pulmonary edema that occurs during or within 6 hours after transfusion. Risk factors for TRALI, which is relatively common in critically ill patients, include recent surgery, hematologic malignancy, and sepsis. Here, we report a case of TRALI induced by anti-human leukocyte antigen (anti-HLA) class II antibodies (HLA-DR) occurring after transfusion of platelet concentrates in a patient with acute leukemia. Although most patients with TRALI show improvement within 48-96 hours, our patient's condition rapidly worsened, and he did not respond to supportive treatment. TRALI is a relatively common and serious adverse transfusion reaction that requires prompt diagnosis and management.
authors: Department of Internal Medicine, CHA University School of Medicine, Seongnam, Korea.
authors: Sun Mi
authors: SM
authors: Jin
authors: Moon Ju
authors: MJ
authors: Jang
authors: Ji Young
authors: JY
authors: Huh
authors: Myoung Hee
authors: MH
authors: Park
authors: Eun Young
authors: EY
authors: Song
authors: Doyeun
authors: D
authors: Oh
keywords: Anti-human leukocyte antigen (anti-HLA) antibody; Transfusion; Transfusion-related acute lung injury (TRALI)