title: Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection.
abstract: Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.
authors: Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan, Taiwan.
authors: Yung-Chun
authors: YC
authors: Chuang
authors: Yee-Shin
authors: YS
authors: Lin
authors: Ching-Chuan
authors: CC
authors: Liu
authors: Hsiao-Sheng
authors: HS
authors: Liu
authors: Shu-Hsing
authors: SH
authors: Liao
authors: Ming-Der
authors: MD
authors: Shi
authors: Huan-Yao
authors: HY
authors: Lei
authors: Trai-Ming
authors: TM
authors: Yeh
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001778:Blood Coagulation Disorders / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D003716:Dengue Virus / Q000276:immunology*; D005342:Fibrinolysis / Q000276:immunology*; D006801:Humans; D018716:Molecular Mimicry; D011516:Prothrombin / Q000378:metabolism; D019595:Severe Dengue / Q000097:blood / Q000150:complications*; D018180:Thrombomodulin / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood; D014764:Viral Proteins / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D016207:Cytokines; D018180:Thrombomodulin; D014764:Viral Proteins; D011516:Prothrombin; D010959:Tissue Plasminogen Activator