title: Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters.
abstract: Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P = .61). The proportion of subtype C-infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa.
authors: Department of Medicine, University of Washington, Seattle, WA 98195, USA. msc6@u.washington.edu
authors: Mary S
authors: MS
authors: Campbell
authors: Erin M
authors: EM
authors: Kahle
authors: Connie
authors: C
authors: Celum
authors: Jairam R
authors: JR
authors: Lingappa
authors: Saidi
authors: S
authors: Kapiga
authors: Andrew
authors: A
authors: Mujugira
authors: Nelly R
authors: NR
authors: Mugo
authors: Kenneth H
authors: KH
authors: Fife
authors: James I
authors: JI
authors: Mullins
authors: Jared M
authors: JM
authors: Baeten
mesh_terms: D000328:Adult; D000351:Africa, Eastern; D044383:Black People; D018562:Disease Transmission, Infectious / Q000517:prevention & control; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000517:prevention & control / Q000821:virology; D006679:HIV Seropositivity / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012367:RNA, Viral / Q000097:blood; D012680:Sensitivity and Specificity; D013019:South Africa; D013997:Time Factors; D019562:Viral Load; D014766:Viremia / Q000821:virology; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D012367:RNA, Viral; D054299:env Gene Products, Human Immunodeficiency Virus; D054301:gag Gene Products, Human Immunodeficiency Virus