title: Microbial amyloids--functions and interactions within the host.
abstract: The aggregation of proteins into amyloid fibers is a common characteristic of many neurodegenerative disorders including Alzheimer's, Parkinson's, and prion diseases. Amyloid formation was originally characterized in these systems and is traditionally viewed as a consequence of protein misfolding and aggregation. An emerging field of study brings functional amyloids, like those produced by bacteria, into the scientific mainstream, and demonstrates a ubiquitous role for amyloids in living systems. This review aims to summarize what is known about the bacterial amyloids and their interactions within various host environments.
authors: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, United States.
authors: Kelly
authors: K
authors: Schwartz
authors: Blaise R
authors: BR
authors: Boles
mesh_terms: D000682:Amyloid / Q000378:metabolism*; D001419:Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D001426:Bacterial Proteins / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D046912:Multiprotein Complexes / Q000378:metabolism*; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D000682:Amyloid; D001426:Bacterial Proteins; D046912:Multiprotein Complexes; D037521:Virulence Factors