title: Propofol attenuates pulmonary injury induced by collapse and reventilation of lung in rabbits.
abstract: Propofol is an anesthetic drug with antioxidant and anti-inflammatory properties. We previously found that propofol attenuated lipopolysaccharide-induced acute lung injury in rabbits. This study was performed to evaluate the effects of propofol on lung injury caused by collapse and reventilation in rabbits. The wet/dry weight ratio of the lung, lung injury scores, percentage of polymorphonuclear leukocytes, albumin concentration, malondialdehyde, and interleukin-8 levels in bronchoalveolar lavage fluid were significantly increased in both lungs of the reventilation group. The degree of increase in these parameters was more significant in the right (reventilated) than in the left (non-reventilated) lung. Propofol attenuated these changes. These findings suggest that reventilation of a collapsed lung can cause injury in the contralateral non-reventilated lung as well as the reventilated lung. Propofol may provide a beneficial effect on lung injury induced by collapse and reventilation of the lung.
authors: Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju 501-757, South Korea.
authors: Hong-Beom
authors: HB
authors: Bae
authors: Mei
authors: M
authors: Li
authors: Seong-Heon
authors: SH
authors: Lee
authors: Cheol-Won
authors: CW
authors: Jeong
authors: Seok-Jai
authors: SJ
authors: Kim
authors: Heong-Seok
authors: HS
authors: Kim
authors: Sung-Su
authors: SS
authors: Chung
authors: Sang-Hyun
authors: SH
authors: Kwak
mesh_terms: D000418:Albumins / Q000032:analysis; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D007249:Inflammation / Q000188:drug therapy; D016209:Interleukin-8 / Q000032:analysis; D007958:Leukocyte Count; D008070:Lipopolysaccharides; D055370:Lung Injury / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D009504:Neutrophils; D015742:Propofol / Q000627:therapeutic use*; D001261:Pulmonary Atelectasis / Q000150:complications; D012123:Pulmonary Ventilation; D011817:Rabbits
chemical_list: D000418:Albumins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016209:Interleukin-8; D008070:Lipopolysaccharides; D008315:Malondialdehyde; D015742:Propofol