title: Role of matrix β-1,3 glucan in antifungal resistance of non-albicans Candida biofilms.
abstract: Candida biofilm infections pose an increasing threat in the health care setting due to the drug resistance associated with this lifestyle. Several mechanisms underlie the resistance phenomenon. In Candida albicans, one mechanism involves drug impedance by the biofilm matrix linked to β-1,3 glucan. Here, we show this is important for other Candida spp. We identified β-1,3 glucan in the matrix, found that the matrix sequesters antifungal drug, and enhanced antifungal susceptibility with matrix β-1,3 glucan hydrolysis.
authors: University of Wisconsin, Madison, Wisconsin, USA.
authors: K F
authors: KF
authors: Mitchell
authors: H T
authors: HT
authors: Taff
authors: M A
authors: MA
authors: Cuevas
authors: E L
authors: EL
authors: Reinicke
authors: H
authors: H
authors: Sanchez
authors: D R
authors: DR
authors: Andes
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism*; D025141:Drug Resistance, Fungal / Q000502:physiology*; D011509:Proteoglycans; D047071:beta-Glucans / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K