title: Precocious puberty produced by an osteolipoma of the tuber cinereum.
abstract: Central precocious puberty (CPP) is fairly common in girls. In most girls, the etiology for the CPP is unknown. Among the more rare causes of CPP in girls are central nervous system tumors and hamartomas. Osteolipoma of the tuber cinereum, which is the most commonly diagnosed at autopsy, has been reported as a cause of CPP. We describe an 8-year-old girl with central precocious puberty in whom MRI demonstrated a lesion compatible with osteolipoma. Her symptom was breast development that begun at age 7 years and 9 months. Her case history, laboratory studies and imaging are presented. Her puberty was rapidly progressive. She was treated successfully with a GnRHa (Triptorelin 3.75 mg IM q 4 weeks). Her case brings to the forefront the need to perform an MRI in children with rapidly progressing puberty.
authors: Department of Pediatrics, Hospital Carmen y Severo Ochoa, Cangas del Narcea, 33012 Oviedo, Asturias, Spain. anaviall@hotmail.com
authors: Ana
authors: A
authors: Vivanco-Allende
authors: Mónica
authors: M
authors: García-González
authors: David
authors: D
authors: González-Jiménez
authors: Alejandro
authors: A
authors: Pérez-Guirado
authors: Isela
authors: I
authors: Fernández
authors: Rafael
authors: R
authors: Gómez-Illan
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis; D000465:Algorithms; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000175:diagnosis; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008067:Lipoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D010048:Ovarian Cysts / Q000175:diagnosis; D010051:Ovarian Neoplasms / Q000175:diagnosis; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome; D014371:Tuber Cinereum / Q000473:pathology*
chemical_list: D007987:Gonadotropin-Releasing Hormone; C083781:LHRH, Ala(6)-Gly(10)-ethylamide-