title: Respiratory syncytial virus infection and recurrent wheezing in Chilean infants: a genetic background?
abstract: Respiratory syncytial virus (RSV) infection has been associated to recurrent wheezing, but pathogenic mechanisms are unclear. Interleukin-4/Interleukin-13 (IL-4/IL-13) pathway is involved in both conditions. A common host genetic susceptibility may exist in patients whom RSV will trigger severe illness and those who develop recurrent wheezing.
  
  
  OBJECTIVE
  To assess, by a candidate-gene approach, whether genetic polymorphisms in IL-4/IL-13 pathway are associated with RSV infection severity and its outcome in Chilean children. A cohort of 118 RSV-infected infants was analyzed and followed for one year. Severity of acute infection and later recurrent wheezing were characterized. Alleles and genotypes frequencies were determined for two SNP in each of the genes IL-4, IL-13 and IL-4Rα. Association tests and interaction analyses were performed. Enrollment included 60 moderate and 58 severe cases. Two SNP were found associated to severity during acute infection in IL-4Rα gene (Gln551Arg, Ile50Val). The follow up was completed in 71% of patients (84/118). Later recurrent wheezing was 54% in severe group, versus 31% in moderate cases (p=0.035). In relation to outcome, allele Ile50 in IL-4Rα was more frequent in patients with moderate disease and no wheezing outcome. A common protector genotype is proposed for Chilean children: IL-4Rα Ile/Ile.
  
  
  CONCLUSIONS
  Genetic variations in the host are associated to infection severity and outcome. A common genetic background might be influencing both pathologies.
authors: Programa de Virología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Chile. ltapia@med.uchile.cl
authors: Lorena I
authors: LI
authors: Tapia
authors: Sandra
authors: S
authors: Ampuero
authors: M Angélica
authors: MA
authors: Palomino
authors: Vivian
authors: V
authors: Luchsinger
authors: Nelson
authors: N
authors: Aguilar
authors: Eliana
authors: E
authors: Ayarza
authors: Rossana
authors: R
authors: Mamani
authors: Carmen
authors: C
authors: Larrañaga
mesh_terms: D002677:Chile / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018793:Interleukin-13 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D008137:Longitudinal Studies; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012135:Respiratory Sounds / Q000235:genetics*; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology / Q000235:genetics*
chemical_list: D018793:Interleukin-13; D015847:Interleukin-4