title: Bacterial protein N-glycosylation: new perspectives and applications.
abstract: Protein glycosylation is widespread throughout all three domains of life. Bacterial protein N-glycosylation and its application to engineering recombinant glycoproteins continue to be actively studied. Here, we focus on advances made in the last 2 years, including the characterization of novel bacterial N-glycosylation pathways, examination of pathway enzymes and evolution, biological roles of protein modification in the native host, and exploitation of the N-glycosylation pathways to create novel vaccines and diagnostics.
authors: Alberta Glycomics Centre and Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada. nothaft@ualberta.ca
authors: Harald
authors: H
authors: Nothaft
authors: Christine M
authors: CM
authors: Szymanski
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D018448:Models, Immunological; D009154:Mutation / Q000276:immunology; D019897:Periplasm / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D006023:Glycoproteins