title: The impact of oxidative stress in thiamine deficiency: a multifactorial targeting issue.
abstract: Thiamine (vitamin B1) deficiency, the underlying cause of Wernicke-Korsakoff syndrome, is associated with the development of focal neuronal loss in vulnerable areas of the brain. Although the actual mechanism(s) that lead to the selective histological lesions characteristic of this disorder remain unresolved, oxidative stress has been shown to play a major role in its pathophysiology. In this review, the multifactorial influence of oxidative stress on a variety of processes known to take part in the development of structural lesions in TD including excitotoxicity, neuroinflammation, blood-brain barrier integrity, mitochondrial integrity, apoptosis, nucleic acid function, and neural stem cells will be discussed, and therapeutic strategies undertaken for treating neurodegeneration examined which may have an impact on the future treatment of this important vitamin deficiency.
authors: Department of Medicine, University of Montreal, Montreal, Quebec, Canada; Departamento de Neurologia, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil. alan.stewart.hazell@umontreal.ca
authors: Alan S
authors: AS
authors: Hazell
authors: Samantha
authors: S
authors: Faim
authors: Guilherme
authors: G
authors: Wertheimer
authors: Vinicius R
authors: VR
authors: Silva
authors: Cleiton S
authors: CS
authors: Marques
mesh_terms: D000818:Animals; D017209:Apoptosis; D001812:Blood-Brain Barrier; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D018384:Oxidative Stress; D013832:Thiamine Deficiency / Q000378:metabolism*