title: [Statin-induced adverse effects -- facts and genes].
abstract: Statin therapy is considered to be safe and rarely associated with serious adverse events. However, a significant proportion of patients on statin therapy show some degree of intolerance which can lead to decreased adherence to statin therapy. The authors summarize the symptoms, signs and frequencies of the most common statin-induced adverse effects and their most important risk factors including some single nucleotide polymorphisms and gene mutations. Also, they review the available approaches to detect and manage the statin-intolerant patients.
authors: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Belgyógyászati Intézet, Anyagcsere Betegségek Tanszék Debrecen Nagyerdei krt. 98. 4032. mharangi@hotmail.com
authors: Mariann
authors: M
authors: Harangi
authors: Noémi
authors: N
authors: Zsíros
authors: Lilla
authors: L
authors: Juhász
authors: György
authors: G
authors: Paragh
mesh_terms: D003071:Cognition / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D004064:Digestive System / Q000187:drug effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000139:chemically induced* / Q000235:genetics; D005919:Glomerular Filtration Rate / Q000187:drug effects; D048550:Hepatic Insufficiency / Q000139:chemically induced*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D015994:Incidence; D008099:Liver / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects*; D009135:Muscular Diseases / Q000139:chemically induced*; D009154:Mutation; D009369:Neoplasms / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors