title: The effect of red grape juice on Alzheimer's disease in rats.
abstract: BACKGROUND
  Alzheimer's disease is a neurodegenerative disease appearing as a result of free radicals and oxidative stress. Antioxidants agents boost memory and control Alzheimer's disease. Since red grape juice contains antioxidant agents, its effects on speed of learning and improvement of memory was studied in Alzheimer's rats.
  
  
  METHODS
  Alzheimer's model was induced by bilateral infusion of streptozocine into lateral ventricles of brain of male rats. Rats drank 10% red grape juice for 21 days. Passive avoidance learning test was used for measuring memory and learning in rats.
  
  
  RESULTS
  Our results showed that learning and memory in STZ-group decreased significantly compared to Sham group. However, intake of red grape juice increased speed of learning and improvement of memory in Alzheimer's rats.
  
  
  CONCLUSIONS
  Our results suggest that there are active ingredients in red grape juice, which probably have therapeutic and preventive effects on cognitive impairments in Alzheimer's disease.
authors: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, India.
authors: Zahra
authors: Z
authors: Siahmard
authors: Hojjatollah
authors: H
authors: Alaei
authors: Parham
authors: P
authors: Reisi
authors: Ali Asghar
authors: AA
authors: Pilehvarian
keywords: Alzheimer's disease; avoidance learning test; red grape juice; streptozotocin