title: Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae).
abstract: BACKGROUND
  Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-D-glucose) is a tannin isolated from Phyllanthus niruri (Euphorbiaceae). This plant is well known for their therapeutic purposes to treat several diseases associated with dolorous process and are used in several ethno-medicines in tropical and subtropical countries.
  
  
  OBJECTIVE
  This study was designed to evaluate the anti-hyperalgesic activity of corilagin using chemically and thermally based nociception models in mice.
  
  
  METHODS
  Corilagin was isolated from Phyllanthus niruri (Euphorbiaceae) by extraction and chromatographic procedures and the anti-hyperalgesic activity was evaluated by using writhing, formalin, capsaicin, glutamate and hot plate tests in mice.
  
  
  RESULTS
  Corilagin presented activity in acetic acid model with the ID50 calculated value of 6.46 (3.09-13.51) being about 20.6 fold more potent than acetylsalicylic acid. It also exhibited activity against the first phase of formalin test with ID50 value of 18.38 (15.15-22.59) μmol/kg. In the capsaicin and glutamate models, corilagin demonstrated significant activity at the 3 mg/kg.
  
  
  CONCLUSIONS
  The experimental data demonstrated that corilagin exhibits anti-hyperalgesic activity that may be due to interaction with the glutamatergic system.
authors: Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí-UNIVALI, 88.302-202, Itajaí, Santa Catarina, Brazil.
authors: Jeverson
authors: J
authors: Moreira
authors: Luiz Carlos
authors: LC
authors: Klein-Júnior
authors: Valdir
authors: V
authors: Cechinel Filho
authors: Fátima
authors: F
authors: de Campos Buzzi
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002211:Capsaicin; D005557:Formaldehyde; D005960:Glucosides / Q000627:therapeutic use*; D018698:Glutamic Acid; D006358:Hot Temperature; D047348:Hydrolyzable Tannins; D006930:Hyperalgesia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D029803:Phyllanthus; D008517:Phytotherapy
chemical_list: D000700:Analgesics; D005960:Glucosides; D047348:Hydrolyzable Tannins; D005557:Formaldehyde; D018698:Glutamic Acid; C049096:corilagin; D019342:Acetic Acid; D002211:Capsaicin