title: Enantioselective liquid-liquid extractions of underivatized general amino acids with a chiral ketone extractant.
abstract: The chiral ketone (S)-3 shows high kinetic enantioselectivities toward the L form for general underivatized amino acids with hydrophobic side chains and a high thermodynamic enantioselectivity toward the D form for cysteine with its -SH polar side chain when used as an extractant in enantioselective liquid-liquid extractions in the presence of Aliquat 336. Consecutive extractions by imine formation and hydrolysis increase the enantiopurity of the amino acid, as both of these reactions are L-form-selective.
authors: Bio-Chiral Lab, Department of Chemistry & Nano Science, Ewha Womans University, Seoul 120-750, Korea.
authors: Haofei
authors: H
authors: Huang
authors: Raju
authors: R
authors: Nandhakumar
authors: Misun
authors: M
authors: Choi
authors: Zhishan
authors: Z
authors: Su
authors: Kwan Mook
authors: KM
authors: Kim
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D007700:Kinetics; D059625:Liquid-Liquid Extraction; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D011789:Quantum Theory; D013237:Stereoisomerism; D013816:Thermodynamics
chemical_list: D000596:Amino Acids; D007659:Ketones