title: Peripheral lymphadenopathy as the initial manifestation of malignant mesothelioma in a child.
abstract: Peripheral lymphadenopathy is a rare presentation in malignant mesothelioma. We describe a unique case of malignant mesothelioma arising in an 11-year-old boy, for whom peripheral lymphadenopathy was the initial manifestation of the disease. The final diagnosis was confirmed by a broad panel of immunohistochemical markers. Literature review disclosed only 2 cases in childhood that initially presented with peripheral lymphadenopathy. Pathologists should be aware of this rare biologic behavior of malignant mesothelioma to reach the correct and prompt diagnosis.
authors: Department of Pathology, Xuzhou Medical College, Xuzhou, 221002, China.
authors: Yu-Sen
authors: YS
authors: Gong
authors: Yu-Tao
authors: YT
authors: Rong
authors: Wen-Can
authors: WC
authors: Han
authors: Ying-Chun
authors: YC
authors: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D000086002:Mesothelioma, Malignant; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor