title: The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration.
abstract: The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-ε are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment.
authors: Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
authors: Markéta
authors: M
authors: Kaucká
authors: Karla
authors: K
authors: Plevová
authors: Sárka
authors: S
authors: Pavlová
authors: Pavlína
authors: P
authors: Janovská
authors: Archana
authors: A
authors: Mishra
authors: Jan
authors: J
authors: Verner
authors: Jirina
authors: J
authors: Procházková
authors: Pavel
authors: P
authors: Krejcí
authors: Jana
authors: J
authors: Kotasková
authors: Petra
authors: P
authors: Ovesná
authors: Boris
authors: B
authors: Tichy
authors: Yvona
authors: Y
authors: Brychtová
authors: Michael
authors: M
authors: Doubek
authors: Alois
authors: A
authors: Kozubík
authors: Jirí
authors: J
authors: Mayer
authors: Sárka
authors: S
authors: Pospísilová
authors: Vítezslav
authors: V
authors: Bryja
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology*; D002465:Cell Movement; D016764:Cell Polarity; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism / Q000473:pathology*; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction; D014183:Transplantation, Heterologous; D015854:Up-Regulation; D060449:Wnt Signaling Pathway
chemical_list: D008565:Membrane Proteins