title: On-substrate fabrication of a bio-conjugated Au nanoring solution for photothermal therapy application.
abstract: The on-substrate fabrication of a bio-conjugated Au nanoring (NRI) solution with the localized surface plasmon (LSP) resonance wavelength in the 1200-1300 nm range is demonstrated. Also, the effects of photothermal therapy through LSP resonance-induced absorption enhancement are illustrated by applying the bio-conjugated Au NRIs to human liver cancer cells and illuminating the cells with a laser of 1315 nm in wavelength. The Au NRI fabrication is based on the techniques of nano-imprint lithography and metal secondary sputtering. The procedure for on-substrate surface modification of Au NRIs leads to a high production yield of bio-conjugated NRIs. The threshold levels of the local laser intensity for injuring cancer cells based on the LSP resonances of Au NRIs of two different samples are determined.
authors: Institute of Photonics and Optoelectronics, and Department of Electrical Engineering, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei, 10617, Taiwan.
authors: Hung-Yu
authors: HY
authors: Tseng
authors: Wei-Fang
authors: WF
authors: Chen
authors: Che-Kuan
authors: CK
authors: Chu
authors: Wen-Yen
authors: WY
authors: Chang
authors: Yang
authors: Y
authors: Kuo
authors: Yean-Woei
authors: YW
authors: Kiang
authors: C C
authors: CC
authors: Yang
mesh_terms: D006046:Gold / Q000737:chemistry / Q000627:therapeutic use*; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use*; D036103:Nanotechnology / Q000379:methods; D010789:Phototherapy / Q000379:methods*; D012996:Solutions; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D012996:Solutions; D006046:Gold