title: Notch inhibitor: a promising carcinoma radiosensitizer.
abstract: Radiotherapy is an important part of modern cancer management for many malignancies, and enhancing the radiosensitivity of tumor cells is critical for effective cancer therapies. The Notch signaling pathway plays a key role in regulation of numerous fundamental cellular processes. Further, there is accumulating evidence that dysregulated Notch activity is involved in the genesis of many human cancers. As such, Notch inhibitors are attractive therapeutic agents, although as for other anticancer agents, they exhibit significant and potential side effects. Thus, Notch inhibitors may be best used in combination with other agents or therapy. Herein, we describe evidence supporting the use of Notch inhibitors as novel and potent radiosensitizers in cancer therapy.
authors: Department of Otolaryngology, Qianfoshan Hospital Affiliated to Shandong University, Shandong, China. yushudong@126.com
authors: Shu-Dong
authors: SD
authors: Yu
authors: Fen-Ye
authors: FY
authors: Liu
authors: Qi-Rong
authors: QR
authors: Wang
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D011836:Radiation Tolerance / Q000187:drug effects*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D051880:Receptors, Notch / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D011838:Radiation-Sensitizing Agents; D051880:Receptors, Notch