title: Cytotoxic cardenolide glycosides from the root of Reevesia formosana.
abstract: Bioassay-guided fractionation of the root tissue of Reevesia formosana led to isolation of 13 cardenolide glycosides, reevesiosides A-I and epi-reevesiosides F-I. Their structures were determined by means of spectroscopic analysis and single-crystal X-ray diffraction was performed using reevesioside A. Reevesioside A, reevesioside F, and epi-reevesioside F displayed especially potent cytotoxicity against the MCF-7 and NCI-H460 cancer cell lines, with IC(50) values of 63±2 and 19±1, 72±8 and 20±0, and 34±6 and 10±1 nM, respectively. Identification of the sugar constituents and unusual 18,20-epoxide cardenolide glycosides are described herein. Cardiac glycosides were previously unknown in the Sterculiaceae family.
authors: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
authors: Hsun-Shuo
authors: HS
authors: Chang
authors: Michael Y
authors: MY
authors: Chiang
authors: Hsing-Yu
authors: HY
authors: Hsu
authors: Cheng-Wei
authors: CW
authors: Yang
authors: Chu-Hung
authors: CH
authors: Lin
authors: Shiow-Ju
authors: SJ
authors: Lee
authors: Ih-Sheng
authors: IS
authors: Chen
mesh_terms: D002298:Cardenolides / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D019660:Malvaceae / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D002298:Cardenolides; D006027:Glycosides