title: Is lung function associated with bone mineral density? Results from the Hertfordshire Cohort Study.
abstract: Given limited information available regarding associations between lung function and bone mineral density among healthy subjects, we undertook these analyses in the Hertfordshire Cohort Study. Forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC were not associated with bone mineral density at any site; associations with bone mineral content were removed by adjustment for body size.
  
  
  OBJECTIVE
  There is limited information available regarding the association between lung function and bone mineral density among healthy elderly subjects. We addressed this issue in the Hertfordshire Cohort Study.
  
  
  METHODS
  From the above cohort, 985 subjects (496 men and 489 women) aged 60-72 years were recruited. All subjects underwent bone density measurements using dual energy X-ray absorptiometry and lung function tests using standardised spirometry. Chronic obstructive pulmonary disease (COPD) was defined as a FEV(1)/FVC ratio <lower limit of normal, calculated using separate equations for men and women.
  
  
  RESULTS
  Measures of lung function (FEV(1), FVC and FEV(1)/FVC) were not associated with bone mineral density at the lumbar spine, femoral neck and total hip in men or women; associations with bone mineral content and bone area were removed by adjustment for body size and lifestyle confounders. In this cohort, there were no associations observed between COPD and any measure of bone mass.
  
  
  CONCLUSIONS
  There was no association between lung function and bone mass in this community dwelling cohort after adjustment for body size and other confounders.
authors: MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, UK.
authors: E M
authors: EM
authors: Dennison
authors: D K
authors: DK
authors: Dhanwal
authors: S O
authors: SO
authors: Shaheen
authors: R
authors: R
authors: Azagra
authors: I
authors: I
authors: Reading
authors: K A
authors: KA
authors: Jameson
authors: A A
authors: AA
authors: Sayer
authors: C
authors: C
authors: Cooper
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density; D015331:Cohort Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D013147:Spirometry; D006113:United Kingdom