title: Association of increased frequencies of HLA-DPB1*05:01 with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese rheumatoid arthritis and systemic lupus erythematosus patients.
abstract: BACKGROUND
  Autoantibodies to ribonucleoprotein are associated with a variety of autoimmune diseases, including rheumatoid arthritis (RA). Many studies on associations between human leukocyte antigen (HLA) alleles and RA have been reported, but few have been validated in RA subpopulations with anti-La/SS-B or anti-Ro/SS-A antibodies. Here, we investigated associations of HLA class II alleles with the presence of anti-Ro/SS-A or anti-La/SS-B antibodies in RA.
  
  
  METHODS
  An association study was conducted for HLA-DRB1, DQB1, and DPB1 in Japanese RA and systemic lupus erythematosus (SLE) patients that were positive or negative for anti-Ro/SS-A and/or anti-La/SS-B antibodies.
  
  
  RESULTS
  An increased prevalence of certain class II alleles was associated with the presence of anti-Ro/SS-A antibodies as follows: DRB1*08:03 (Pc = 3.79×10(-5), odds ratio [OR] 3.06, 95% confidence interval [CI] 1.98-4.73), DQB1*06:01 (Pc = 0.0106, OR 1.70, 95%CI 1.26-2.31), and DPB1*05:01 (Pc = 0.0040, OR 1.55, 95%CI 1.23-1.96). On the other hand, DRB1*15:01 (Pc = 0.0470, OR 3.14, 95%CI 1.63-6.05), DQB1*06:02 (Pc = 0.0252, OR 3.14, 95%CI 1.63-6.05), and DPB1*05:01 (Pc = 0.0069, OR 2.27, 95% CI 1.44-3.57) were associated with anti-La/SS-B antibodies. The DPB1*05:01 allele was associated with anti-Ro/SS-A (Pc = 0.0408, OR 1.69, 95% CI 1.19-2.41) and anti-La/SS-B antibodies (Pc = 2.48×10(-5), OR 3.31, 95%CI 2.02-5.43) in SLE patients.
  
  
  CONCLUSIONS
  HLA-DPB1*05:01 was the only allele associated with the presence of both anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese RA and SLE patients.
authors: Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan. h-furukawa@sagamihara-hosp.gr.jp
authors: Hiroshi
authors: H
authors: Furukawa
authors: Shomi
authors: S
authors: Oka
authors: Kota
authors: K
authors: Shimada
authors: Shoji
authors: S
authors: Sugii
authors: Atsushi
authors: A
authors: Hashimoto
authors: Akiko
authors: A
authors: Komiya
authors: Naoshi
authors: N
authors: Fukui
authors: Tatsuo
authors: T
authors: Nagai
authors: Shunsei
authors: S
authors: Hirohata
authors: Keigo
authors: K
authors: Setoguchi
authors: Akira
authors: A
authors: Okamoto
authors: Noriyuki
authors: N
authors: Chiba
authors: Eiichi
authors: E
authors: Suematsu
authors: Taiichiro
authors: T
authors: Miyashita
authors: Kiyoshi
authors: K
authors: Migita
authors: Akiko
authors: A
authors: Suda
authors: Shouhei
authors: S
authors: Nagaoka
authors: Naoyuki
authors: N
authors: Tsuchiya
authors: Shigeto
authors: S
authors: Tohma
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood*; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D056726:Genetic Association Studies; D059868:HLA-DP beta-Chains / Q000235:genetics*; D059866:HLA-DQ beta-Chains / Q000235:genetics; D059811:HLA-DRB1 Chains / Q000235:genetics; D006801:Humans; D007564:Japan; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000235:genetics / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; C538744:HLA-DPB1*05:01 antigen; D059866:HLA-DQ beta-Chains; C057615:HLA-DQbeta antigen; D059811:HLA-DRB1 Chains; C035356:SS-A antibodies; C035357:SS-B antibodies