title: Evolutionary rate of human tissue-specific genes are related with transposable element insertions.
abstract: The influence of transposable elements (TEs) on genome evolution has been widely studied. However, it remains unclear whether TE insertions also impact on evolutionary rate of human genes. In this study, we have compared the differences in TEs and evolutionary rates between human tissue-specific genes. Our results showed that various functional categories of human tissue-specific genes contained different TE numbers and divergent values of Ka/Ks, with human nucleic acid binding transcription factor activity genes having the fewest TE density and Ka/Ks value. Interestingly, we also found that human tissue-specific genes with TEs have also undergone faster evolution than those without TEs. Therefore, TEs have significant impact on the evolutionary rates of human tissue-specific genes. Furthermore, local genomic properties such as gene length, GC content and recombination rate may reflect a true transpositional bias for the particular TEs. Our results may provide important insights for further elucidating the evolution of human tissue-specific genes.
authors: Laboratory for Comparative Genomics and Bioinformatics & Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, 210046, China.
authors: Ping
authors: P
authors: Jin
authors: Sheng
authors: S
authors: Qin
authors: Xi
authors: X
authors: Chen
authors: Yumei
authors: Y
authors: Song
authors: Jesse
authors: J
authors: Li-Ling
authors: Xiaofeng
authors: X
authors: Xu
authors: Fei
authors: F
authors: Ma
mesh_terms: D001482:Base Composition; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D015894:Genome, Human; D006801:Humans; D009928:Organ Specificity / Q000235:genetics; D011995:Recombination, Genetic; D012044:Regression Analysis; D016415:Sequence Alignment
chemical_list: D004251:DNA Transposable Elements