title: Acute liver failure with thyrotoxicosis treated with liver transplantation.
abstract: OBJECTIVE
  We describe a young woman with previously undiagnosed thyrotoxicosis who presented with acute liver failure (ALF).
  
  
  METHODS
  We present a case report and review the relevant literature.
  
  
  RESULTS
  An extensive evaluation excluded possible causes of ALF other than thyrotoxicosis. The management of thyrotoxicosis posed several unique challenges in the setting of ALF, particularly because we did not want to use potentially hepatotoxic thionamides. The patient was treated with prednisone and propranolol and was started on potassium iodide when she was listed for liver transplantation. She underwent an uncomplicated liver transplant and subsequent thyroidectomy and is doing well.
  
  
  CONCLUSIONS
  This well-characterized case describes thyrotoxicosis as a possible cause of ALF after thoroughly excluding other possible causes and illustrates the challenges of simultaneously managing both disorders. To our knowledge, this is the first report of ALF possibly resulting from untreated thyrotoxicosis that was successfully treated with liver transplantation.
authors: Department of Medicine, University of California, San Francisco, California, USA.
authors: Matthew D
authors: MD
authors: Cascino
authors: Brian
authors: B
authors: McNabb
authors: David G
authors: DG
authors: Gardner
authors: Kenneth A
authors: KA
authors: Woeber
authors: Alyson N
authors: AN
authors: Fox
authors: Bruce
authors: B
authors: Wang
authors: Oren K
authors: OK
authors: Fix
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D017114:Liver Failure, Acute / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery*; D016031:Liver Transplantation; D011193:Potassium Iodide / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D013971:Thyrotoxicosis / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D011193:Potassium Iodide; D011433:Propranolol; D011241:Prednisone