title: Meta-analysis of the relationship between the LOC387715/ARMS2 polymorphism and polypoidal choroidal vasculopathy.
abstract: We  investigated the association between the LOC387715/ARMS2 polymorphism  (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy  (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight  case-control studies. The genetic effect of the LOC387715/ARMS2 rs10490924 G>T  polymorphism on PCV was assessed by calculating pooled odds ratios (ORs) with  95% confidence intervals (95%CIs). We found that elevated PCV risk was  significantly associated with the GG genotype (GG vs TT, OR = 4.23,  95%CI = 3.53-5.06), and heterozygous genotype TG appeared to have a minor  effect on PCV risk (TG vs TT, OR = 1.47, 95%CI = 1.26-1.71). Patients  with the T allele were 2.09 times more likely to have PCV than those with the G  allele (95%CI = 1.906-2.288). A further subgroup analysis by ages also showed  that the genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism  on PCV is stronger among patients with mean age <73 years. Our meta-analysis  strengthened the evidence that the LOC387715/ARMS2 rs10490924 G>T  polymorphism plays an important role in PCV susceptibility.
authors: Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
authors: J J
authors: JJ
authors: Jiang
authors: X
authors: X
authors: Wu
authors: P
authors: P
authors: Zhou
authors: W Z
authors: WZ
authors: Yu
authors: L Z
authors: LZ
authors: Huang
authors: X X
authors: XX
authors: Li
mesh_terms: D016022:Case-Control Studies; D002829:Choroid / Q000098:blood supply / Q000473:pathology; D015862:Choroid Diseases / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D014652:Vascular Diseases / Q000235:genetics*
chemical_list: C514392:ARMS2 protein, human; D011506:Proteins