title: The multimodal connectivity of the hippocampal complex in auditory and visual hallucinations.
abstract: Hallucinations constitute one of the most representative and disabling symptoms of schizophrenia. Several Magnetic Resonance Imaging (MRI) findings support the hypothesis that distinct patterns of connectivity, particularly within networks involving the hippocampal complex (HC), could be associated with different hallucinatory modalities. The aim of this study was to investigate HC connectivity as a function of the hallucinatory modality, that is, auditory or visual. Two carefully selected subgroups of schizophrenia patients with only auditory hallucinations (AH) or with audio-visual hallucinations (A+VH) were compared using the following three complementary multimodal MRI methods: resting state functional MRI, diffusion MRI and structural MRI were used to analyze seed-based Functional Connectivity (sb-FC), Tract-Based Spatial Statistics (TBSS) and shape analysis, respectively. Sb-FC was significantly higher between the HC, the medial prefrontal cortex (mPFC) and the caudate nuclei in A+VH patients compared with the AH group. Conversely, AH patients exhibited a higher sb-FC between the HC and the thalamus in comparison with the A+VH group. In the A+VH group, TBSS showed specific higher white matter connectivity in the pathways connecting the HC with visual areas, such as the forceps major and the inferior-fronto-occipital fasciculus than in the AH group. Finally, shape analysis showed localized hippocampal hypertrophy in the A+VH group. Functional results support the fronto-limbic dysconnectivity hypothesis of schizophrenia, while specific structural findings indicate that plastic changes are associated with hallucinations. Together, these results suggest that there are distinct connectivity patterns in patients with schizophrenia that depend on the sensory-modality, with specific involvement of the HC in visual hallucinations.
authors: 1] Univ Lille Nord de France, CHRU de Lille, Lille, France [2] Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université Droit & Santé Lille (UDSL), Lille, France [3] Psychiatry and Pediatric Psychiatry Department, University Medical Centre of Lille (CHULille), Lille, France.
authors: A
authors: A
authors: Amad
authors: 1] INSERM U894, Centre de Psychiatrie & Neurosciences (Paris-Descartes University), Paris, France [2] CNRS U3521, Laboratoire de Psychologie du développement et de l'Éducation de l'Enfant, Paris, France [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors: A
authors: A
authors: Cachia
authors: INSERM U894, Centre de Psychiatrie & Neurosciences (Paris-Descartes University), Paris, France.
authors: P
authors: P
authors: Gorwood
authors: 1] Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université Droit & Santé Lille (UDSL), Lille, France [2] Centre National de la Recherche Scientifique (CNRS), Paris, France.
authors: D
authors: D
authors: Pins
authors: 1] Univ Lille Nord de France, CHRU de Lille, Lille, France [2] Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université Droit & Santé Lille (UDSL), Lille, France [3] Neuroradiology Department, University Medical Centre of Lille (CHULille), Lille, France.
authors: C
authors: C
authors: Delmaire
authors: 1] Univ Lille Nord de France, CHRU de Lille, Lille, France [2] Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université Droit & Santé Lille (UDSL), Lille, France [3] Psychiatry and Pediatric Psychiatry Department, University Medical Centre of Lille (CHULille), Lille, France.
authors: B
authors: B
authors: Rolland
authors: 201;quipe d'Accueil 4615, Université Claude Bernard Lyon 1 (UCBL); Centre Hospitalier le Vinatier, Bron, France.
authors: M
authors: M
authors: Mondino
authors: 1] Univ Lille Nord de France, CHRU de Lille, Lille, France [2] Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université Droit & Santé Lille (UDSL), Lille, France [3] Psychiatry and Pediatric Psychiatry Department, University Medical Centre of Lille (CHULille), Lille, France.
authors: P
authors: P
authors: Thomas
authors: 1] Univ Lille Nord de France, CHRU de Lille, Lille, France [2] Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université Droit & Santé Lille (UDSL), Lille, France [3] Psychiatry and Pediatric Psychiatry Department, University Medical Centre of Lille (CHULille), Lille, France.
authors: R
authors: R
authors: Jardri
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001307:Auditory Perception; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000473:pathology / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006212:Hallucinations / Q000188:drug therapy / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000502:physiology; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology; D012146:Rest / Q000502:physiology; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology; D014795:Visual Pathways / Q000473:pathology / Q000503:physiopathology; D014796:Visual Perception
chemical_list: D014150:Antipsychotic Agents