title: Coexistence of mupirocin and antiseptic resistance in methicillin-resistant Staphylococcus aureus isolates from Korea.
abstract: In this study, we determined the prevalence of mupirocin and antiseptics resistance in methicillin-resistant Staphylococcus aureus (MRSA) at a secondary- and a tertiary-care hospital in Korea. Mupirocin susceptibility test, ileS gene sequencing, and polymerase chain reaction for mupA, qacA/B, and smr gene were performed with 456 nonduplicated MRSA isolates collected from 2 hospitals in Korea. Genetic relatedness was determined by spa typing and multilocus sequence typing (MLST). The rates of low-level and high-level mupirocin resistance were 7% and 2% in the secondary-care hospital and 17% and 2% in the tertiary-care hospital, respectively. The positive rate of qacA/B and smr gene in mupirocin-resistant MRSA was 65% and 71%, respectively. In spa typing, most mupirocin-resistant MRSA showed genetic relatedness and some of the highly resistant isolates were ST239 and ST5 in MLST analysis. The distribution of low-level and high-level mupirocin resistance and the coexistence of antiseptic resistance in MRSA can result in failure of decolonization in Korea.
authors: Department of Laboratory Medicine, Myongji Hospital, Kwandong University College of Medicine, Goyang, South Korea.
authors: Hyukmin
authors: H
authors: Lee
authors: Hwansub
authors: H
authors: Lim
authors: Il Kown
authors: IK
authors: Bae
authors: Dongeun
authors: D
authors: Yong
authors: Seok Hoon
authors: SH
authors: Jeong
authors: Kyungwon
authors: K
authors: Lee
authors: Yunsop
authors: Y
authors: Chong
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D017920:Antiporters / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques / Q000379:methods; D024901:Drug Resistance, Multiple, Bacterial; D005798:Genes, Bacterial; D006801:Humans; D015994:Incidence; D026901:Membrane Transport Proteins / Q000235:genetics; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D016712:Mupirocin / Q000494:pharmacology*; D009687:Nuclear Proteins / Q000235:genetics; D056910:Republic of Korea / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000453:epidemiology*; D062606:Tertiary Care Centers
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D017920:Antiporters; D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D009687:Nuclear Proteins; C099272:QacB protein, Staphylococcus aureus; C480380:mupA protein, Staphylococcus aureus; C521590:small multidrug-resistance pump, Staphylococcus aureus; D016712:Mupirocin