title: CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinomas of gallbladder.
abstract: Cofilin-1 (CFL1) and Arp3 expression in 46 squamous cell and adenosquamous carcinomas (SC/ASCs) and 80 adenocarcinomas (ACs) were measured by using immunohistochemistry. Positive CFL1 and Arp3 expression were significantly associated with large tumor size, high TNM stage, lymph node metastasis, and decreased overall survival in both SC/ASC and AC patients (p < .001). Multivariate Cox regression analysis showed that positive CFL1 and Arp3 expression are independent poor-prognostic factors for both SC/ASC and AC patients. Our study suggested that positive CFL1 and Arp3 expression are closely related to tumor progression, metastasis, and poor prognosis of gallbladder cancer.
authors: Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
authors: Zhu-Lin
authors: ZL
authors: Yang
authors: Xiongying
authors: X
authors: Miao
authors: Li
authors: L
authors: Xiong
authors: Qiong
authors: Q
authors: Zou
authors: Yuan
authors: Y
authors: Yuan
authors: Jinghe
authors: J
authors: Li
authors: Lufeng
authors: L
authors: Liang
authors: Meigui
authors: M
authors: Chen
authors: Senlin
authors: S
authors: Chen
mesh_terms: D051378:Actin-Related Protein 3 / Q000235:genetics / Q000378:metabolism*; D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D018196:Carcinoma, Adenosquamous / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D051338:Cofilin 1 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005706:Gallbladder Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis
chemical_list: C495928:ACTR3 protein, human; D051378:Actin-Related Protein 3; D014408:Biomarkers, Tumor; C495810:CFL1 protein, human; D051338:Cofilin 1