title: The regulation and functional impact of actin assembly at cadherin cell-cell adhesions.
abstract: Cadherin adhesion receptors are critical components for the maintenance of tissue architecture and organisation during development and in post-embryonic life. These receptors influence the actin cytoskeletal network by controlling its assembly at the junctions. Likewise, the actin cytoskeleton is required for cadherin integrity at cell-cell contacts. The junctional cytoskeleton is intrinsically dynamic and undergoes constant assembly and reorganisation to maintain a morphologically stable structure. This is governed by a host of molecular players that regulate actin assembly during nucleation and at post-nucleation stages. This review highlights the molecular machinery implicated in actin organisation at various stages of junctional assembly and its functional impact in simple epithelia and other model systems.
authors: Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland 4072, Australia. m.michael@imb.uq.edu.au
authors: Magdalene
authors: M
authors: Michael
authors: Alpha S
authors: AS
authors: Yap
mesh_terms: D008841:Actin Cytoskeleton / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D000199:Actins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D015820:Cadherins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology*; D006801:Humans
chemical_list: D000199:Actins; D015820:Cadherins