title: Systematic analysis on the relationship between luminal enhancement, convolution kernel, plaque density, and luminal diameter of coronary artery stenosis: a CT phantom study.
abstract: To systematically investigate into the relationships between luminal enhancement, convolution kernel, plaque density, and stenosis severity in coronary computed tomography (CT) angiography. A coronary phantom including 63 stenoses (stenosis severity, 10-90%; plaque densities, -100 to 1,000 HU) was loaded with increasing solutions of contrast material (luminal enhancement, 0-700 HU) and scanned in an anthropomorphic chest. CT data was acquired with prospective triggering using 64-section dual-source CT; reconstructions were performed with soft-tissue (B26f) and sharp convolution kernels (B46f). Two blinded and independent readers quantitatively assessed luminal diameter and CT number of plaque using electronic calipers. Measurement bias between phantom dimensions and CT measurements were calculated. Multivariate linear regression models identified predictors of bias. Inter- and intra-reader agreements of luminal diameter and CT number measurements were excellent (ICCs > 0.91, p < 0.01, each). Measurement bias of luminal diameter and plaque density was significantly (p < 0.01, each) lower (-12% and 58 HU, respectively) with B46f as opposed to B26f, especially in plaque densities >200 HU. Measurement bias was significantly (p < 0.01, each) correlated (ρ = 0.37-55 and ρ = -0.70-85) with the differences between luminal enhancement and plaque density. In multivariate models, bias of luminal diameter assessment with CT was correlated with plaque density (β = 0.09, p < 0.05). Convolution kernel (β = -0.29 and -0.38), stenosis severity (β = -0.45 and -0.38), and luminal enhancement (β = -0.11 and -0.29) represented independent (p < 0.05,each) predictors of measurement bias of luminal diameter and plaque number, respectively. Significant independent relationships exist between luminal enhancement, convolution kernel, plaque density, and luminal diameter, which have to be taken into account when performing, evaluating, and interpreting coronary CT angiography.
authors: Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 8091 Zurich, Switzerland.
authors: Fabian
authors: F
authors: Morsbach
authors: Nicole
authors: N
authors: Berger
authors: Lotus
authors: L
authors: Desbiolles
authors: Tadea
authors: T
authors: Poropat
authors: Sebastian
authors: S
authors: Leschka
authors: Hatem
authors: H
authors: Alkadhi
authors: Paul
authors: P
authors: Stolzmann
mesh_terms: D017023:Coronary Angiography / Q000295:instrumentation* / Q000379:methods; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D006801:Humans; D016014:Linear Models; D061330:Multidetector Computed Tomography / Q000295:instrumentation*; D015999:Multivariate Analysis; D015588:Observer Variation; D019047:Phantoms, Imaging; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D011857:Radiographic Image Interpretation, Computer-Assisted; D015203:Reproducibility of Results