title: An experimental model of aortic surgery and the effect of Iloprost on lung injury.
abstract: OBJECTIVE
  Ischemia/reperfusion (I/R) damage of the lung is a frequently encountered complication following aortic surgery. The aim of the present study is to investigate the histopathological effects of Iloprost on pulmonary damage developed after I/R.
  
  
  METHODS
  Twenty-four Sprague-Dawley rats were randomly divided into 3 groups. In the control group, aortas were not clamped. In the I/R group, aortas were occluded, and after 1 h of ischemia, clamps were removed. After 2 h of reperfusion period, lungs of the rats were extracted. In the I/R + Iloprost group after 1 h of ischemia, Iloprost infusion was initiated, and maintained for the duration of 2 h reperfusion period. For histopathological scoring, density of polymorphonuclear leucocytes, congestion, interstitial edema, and bleeding were semiquantitatively evaluated, and histopathological changes were scored.
  
  
  RESULTS
  In the I/R group, multifocal-marked histopathological changes in 5 (62.5%), and multifocal-moderate histopathological changes in 3 (37.5%) rats were detected. In the I/R + Iloprost group, multifocal-moderate histopathological changes in 4 (50%), and multifocal-mild changes in 4 (50%) rats were detected.
  
  
  CONCLUSIONS
  In the experimental rat model, administration of Iloprost has been shown to have preventive effects for pulmonary damage occurring after I/R generated by infrarenal aortic occlusion.
authors: Department of Cardiovascular Surgery, Faculty of Medicine, Trakya University, Edirne 22030, Turkey. sahiniscan@hotmail.com
authors: Sahin
authors: S
authors: Iscan
authors: Serhat
authors: S
authors: Huseyin
authors: A Coskun
authors: AC
authors: Ozdemir
authors: Tulin
authors: T
authors: Yalta
authors: Volkan
authors: V
authors: Yuksel
authors: Volkan
authors: V
authors: Aksu
authors: Turan
authors: T
authors: Ege
mesh_terms: D000818:Animals; D001011:Aorta / Q000601:surgery*; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000494:pharmacology*; D019610:Cytoprotection; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005260:Female; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D055370:Lung Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D002317:Cardiovascular Agents; D016285:Iloprost