title: Prognostic factors determining recurrence in early-stage endometrial cancer.
abstract: OBJECTIVE
  This study aimed to determine the clinically important prognostic factors for loco-regional or distant recurrence in early-stage endometrial cancer.
  
  
  METHODS
  This study complied with the Declaration of Helsinki, and the local ethics committee approved the study. Cases who underwent primary surgery of early-stage endometrial cancer at the Institution from 2000 to 2012 were reviewed retrospectively. Patients who did not detect recurrence were classified as group 1 (n = 200); those who detected recurrence were classified as group 2 (n = 23). Clinically prognostic factors were evaluated by univariate analyses.
  
  
  RESULTS
  The average age for group 2 (LUSI) was 63.8 years (p = 0.0001). Patients with grade 3 histology were all detected within group 2 (p = 0.0001). Endometrioid adenocarcinoma displaying squamous differentiation was found with a rate of 58.3% in group 2 (p = 0.0001). Lower uterine segment involvement (LUSI) and lymphovascular space invasion (LVSI) rates were 86.9% in group 2 (p = 0.0001). The rate of tumor size > 2 cm was 56.6% in group 2 (p = 0.0001). The median depth of myometrial invasion (DMI) was 5.1 mm (p = 0.034) and the average in myometrial thickness was 14.5 mm in group II (p = 0.0001). The percentage of myometrial invasion was 35.8% in Group II (p = 0.0001). Tumor free-distance was 9.4 mm in group II (p = 0.0001).
  
  
  CONCLUSIONS
  Age and clinicopathological parameters of the tumours are significant predictors for recurrence in early-stage endometrial cancer.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors: S
authors: S
authors: Misirlioglu
authors: A B
authors: AB
authors: Guzel
authors: U K
authors: UK
authors: Gulec
authors: D
authors: D
authors: Gumurdulu
authors: M A
authors: MA
authors: Vardar
mesh_terms: D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D009367:Neoplasm Staging; D011379:Prognosis