title: Assessment of Aurora A kinase expression in breast cancer: a tool for early diagnosis?
abstract: Aurora A kinase is overexpressed in many cancers but the status of this protein in the breast cancer often varies. We investigate the expression and localization of Aurora A protein in relation with tumor emergence and progression in breast cancer. Aurora A kinase status was evaluated in 107 patients using immunohistochemistry. The experimental findings showed that high expression of the Aurora A protein was correlated with elevated nuclear grade, low expression of progesterone receptor and positive nodal status. The experimental results showed also that the localization of this kinase shifts from cytoplasm in non malignant adjacent tissue to both cytoplasmic and nuclear compartments in tumoral tissue, suggesting an oncogenic role of the nuclear accumulation. We have, furthermore, detected the overexpression of this protein in non malignant adjacent tissue. The expression of the Aurora A kinase in non malignant tissue may represent an earlier diagnosis tool for breast cancer.
authors: Laboratory of Genetics, Immunology and Human Pathology, Department of Biology, Faculty of Sciences of Tunis, Tunis, Tunisia. science.biologique@yahoo.fr
authors: Imen
authors: I
authors: Ferchichi
authors: Samia
authors: S
authors: Sassi Hannachi
authors: Amal
authors: A
authors: Baccar
authors: Raja
authors: R
authors: Marrakchi Triki
authors: Jean Yves
authors: JY
authors: Cremet
authors: Khaled
authors: K
authors: Ben Romdhane
authors: Claude
authors: C
authors: Prigent
authors: Amel
authors: A
authors: Ben Ammar El Gaaied
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000918:Antibody Specificity; D064127:Aurora Kinases; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology; D003593:Cytoplasm / Q000378:metabolism; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008875:Middle Aged; D017346:Protein Serine-Threonine Kinases / Q000032:analysis* / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D011980:Receptors, Progesterone; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases