title: Immunohistochemical study of a canine neurofibroma.
abstract: Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others  have not been firmly established. The aim of this case report was to diagnose neurofibroma  using a combination of diagnostic imaging, histopathology and immunohistochemistry,  which were applied to a canine neurofibroma arising in the left mandible. The tumour was  surgically excised and examined histologically. Round or spindle cells, with elongated, dense  and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant  fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry  demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may  therefore be recognisable using markers such as S-100 and vimentin.
authors: Department of Surgery, Science and Research Branch, Islamic Azad University, Iran. hrfattahian@srbiau.ac.ir
authors: Hamidreza
authors: H
authors: Fattahian
authors: Pejman
authors: P
authors: Mortazavi
authors: Hamidreza
authors: H
authors: Moosavian
authors: Hamid
authors: H
authors: Mohyeddin
authors: Roozbeh
authors: R
authors: Moridpour
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000276:immunology / Q000378:metabolism*; D004285:Dogs; D005260:Female; D009455:Neurofibroma / Q000276:immunology / Q000378:metabolism / Q000601:surgery / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000276:immunology / Q000378:metabolism / Q000601:surgery / Q000662:veterinary*