title: Pilot randomized trial of bupropion for adolescent methamphetamine abuse/dependence.
abstract: OBJECTIVE
  To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents.
  
  
  METHODS
  Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling.
  
  
  RESULTS
  Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo (p = .043) and males (p = .005) respectively.
  
  
  CONCLUSIONS
  Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes.
authors: UCLA Center for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, CA 90095, USA. KHeinzerling@mednet.ucla.edu
authors: Keith G
authors: KG
authors: Heinzerling
authors: Janette
authors: J
authors: Gadzhyan
authors: Henry
authors: H
authors: van Oudheusden
authors: Felipe
authors: F
authors: Rodriguez
authors: James
authors: J
authors: McCracken
authors: Steven
authors: S
authors: Shoptaw
mesh_terms: D000293:Adolescent; D000553:Ambulatory Care; D019969:Amphetamine-Related Disorders / Q000534:rehabilitation*; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000627:therapeutic use*; D016642:Bupropion / Q000009:adverse effects / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D015141:Los Angeles; D008297:Male; D008694:Methamphetamine; D010865:Pilot Projects; D055502:Secondary Prevention; D012737:Sex Factors; D015813:Substance Abuse Detection / Q000706:statistics & numerical data; D015819:Substance Abuse, Intravenous / Q000534:rehabilitation*; D055815:Young Adult
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003692:Delayed-Action Preparations; D016642:Bupropion; D008694:Methamphetamine