title: [Effect of aconiti lateralis radix praeparata and taraxaci herba on Chinese medicine signs and symptoms of urethane-induced lung cancer in mice].
abstract: OBJECTIVE
  To study Chinese medicine (CM) signs and symptoms of urethane-induced lung cancer in mice, and observe the effect of Aconiti Lateralis Radix Praeparata and Taraxaci Herba on symptoms in mice and tumor progress.
  
  
  METHODS
  The mice were intraperitoneally injected with urethane twice a week for consecutively five weeks to establish a lung cancer model. The changes in their appearance, body temperature and auricle microcirculation were observed in carcinogenic process. CM signs and symptoms of urethane-induced lung cancer in mice were evaluated with energy metabolism, erythrocytic ATP emzymatic activity and hemorrheological index. During the tumor model was induced, Aconiti Lateralis Radix Praeparata and Taraxaci Herba were used to treat the mice and observe their effect on symptoms in mice and tumor progress.
  
  
  RESULTS
  During urethane was used to induce lung cancer, the mice had gradually become chill, lazy, hunched, with reduction in temperature, cyanosis in auricle and tail. Meanwhile, their energy metabolism and erythrocytic ATP enzymatic activity reduced, whereas their whole blood viscosity and erythrocytic aggregate index increased. Taraxaci Herba showed an effect on enhancing above symptoms and signs but had no effect on tumor progress. Aconiti Lateralis Radix Praeparata showed an effect on reducing above symptoms and signs and preventing tumor progress.
  
  
  CONCLUSIONS
  Mice with urethane-induced lung cancer show CM signs and symptoms of congealing cold with blood stasis. The treatment with Aconiti Lateralis Radix Praeparata can alleviate symptoms and signs in mice and prevent tumor progress.
authors: Drug Research Institute, Pharmaceutical College of Henan University, Kaifeng 475001, China.
authors: Ting
authors: T
authors: Sun
authors: Gang-Jun
authors: GJ
authors: Du
authors: Ya-Ping
authors: YP
authors: Zhang
authors: Jia-Huan
authors: JH
authors: Li
authors: Wei-Jie
authors: WJ
authors: Liu
authors: Ying-Ying
authors: YY
authors: Wang
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009385:Neoplastic Processes; D031205:Taraxacum / Q000737:chemistry*; D014520:Urethane / Q000009:adverse effects
chemical_list: D004365:Drugs, Chinese Herbal; D014520:Urethane