title: Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats.
abstract: A question still to be answered is whether ethanol initiation has a greater effect on ethanol consumption if it occurs during adolescence than in adulthood. This study assessed the effect of ethanol initiation during adolescence or adulthood on voluntary ethanol consumption when animals were still within the same age range. Adolescent or adult rats were given 5, 2, or 0 ethanol exposures. The animals were tested for ethanol consumption through two-bottle choice tests, before undergoing a 1-week deprivation. A two-bottle assessment was conducted after the deprivation. Adolescents, but not adults, given two ethanol administrations during initiation exhibited significantly higher ethanol intake during the pre-deprivation period. These adolescents also exhibited a threefold increase in ethanol intake after 7 days of drug withdrawal, when compared with controls. These findings suggest that very brief experience with binge ethanol intoxication in adolescence, but not in adulthood, impacts later predisposition to drink.
authors: Instituto de Investigación Médica M. y M. Ferreyra, INIMEC-CONICET, Universidad Nacional de Córdoba, Córdoba, C.P. 5000, Argentina; Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, C.P. 5000, Argentina.
authors: María Carolina
authors: MC
authors: Fabio
authors: Michael E
authors: ME
authors: Nizhnikov
authors: Norman E
authors: NE
authors: Spear
authors: Ricardo Marcos
authors: RM
authors: Pautassi
mesh_terms: D000367:Age Factors; D000428:Alcohol Drinking / Q000503:physiopathology*; D000818:Animals; D063425:Binge Drinking / Q000503:physiopathology*; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000431:Ethanol
keywords: adolescent; ethanol initiation; ethanol intake; light-dark test; rat