title: In vivo evaluation of a novel implant coating agent: laminin-1.
abstract: OBJECTIVE
  The aim of this study was to assess the effect of implant coating with laminin-1 on the early stages of osseointegration in vivo.
  
  
  METHODS
  Turned titanium implants were coated with the osteoprogenitor-stimulating protein, laminin-1 (TL). Their osteogenic performance was assessed with removal torque, histomorphometry, and nanoindentation in a rabbit model after 2 and 4 weeks. The performance of the test implants was compared with turned control implants (T), alkali- and heat-treated implants (AH), and AH implants coated with laminin-1.
  
  
  RESULTS
  After 2 weeks, TL demonstrated significantly higher removal torque as compared with T and equivalent to AH. Bone area was significantly higher for the test surface after 4 weeks, while no significant changes were detected on the micromechanical properties of the surrounding bone.
  
  
  CONCLUSIONS
  Within the limitations of this study, our results suggest a great potential for laminin-1 as a coating agent. A turned implant surface coated with laminin-1 could enhance osseointegration comparable with a bioactive implant surface while keeping the surface smooth.
authors: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors: Kostas
authors: K
authors: Bougas
authors: Ryo
authors: R
authors: Jimbo
authors: Stefan
authors: S
authors: Vandeweghe
authors: Nick
authors: N
authors: Tovar
authors: Marta
authors: M
authors: Baldassarri
authors: Ali
authors: A
authors: Alenezi
authors: Malvin
authors: M
authors: Janal
authors: Paulo G
authors: PG
authors: Coelho
authors: Ann
authors: A
authors: Wennerberg
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D007797:Laminin; D011817:Rabbits; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D007797:Laminin; C121346:laminin 1
keywords: biochemical coating; implants; laminin-1; titanium