title: Risk of type 2 diabetes and cumulative excess weight exposure in the Framingham Offspring Study.
abstract: OBJECTIVE
  Mid-life obesity is associated with T2D risk. However, less is known about the cumulative effect of obesity during adulthood.
  
  
  METHODS
  Framingham Offspring Study participants who had an examination at 35±2 years and were initially free of T2D were included in this study (N=1026). A cumulative excess weight (CEW) score (year*kg/m²) was calculated until T2D diagnostic or the end of follow-up.
  
  
  RESULTS
  Eighty-four individuals (8.2%) developed T2D over 20±6 years. Mean CEW scores were 118.0±114.6 year*kg/m² in individuals who developed T2D and 30.2±91.4 year*kg/m² in those who did not develop T2D (P<0.01). T2D risk was doubled for each standard deviation increase in the CEW score (OR=1.99 [1.64-2.40]; P<0.001). However, CEW score was only significantly associated with T2D incidence for participants with a baseline BMI <25 kg/m² (OR =2.13 [1.36-3.36]; P<0.001).
  
  
  CONCLUSIONS
  Accumulating weight between the mid-thirties to the mid-fifties increases the risk of developing T2D. However, BMI in mid-thirties remains a stronger predictor of T2D risk.
authors: Faculty of Kinesiology and Recreation Management, University of Manitoba Winnipeg MB, Canada.
authors: Danielle R
authors: DR
authors: Bouchard
authors: Bianca
authors: B
authors: Porneala
authors: Ian
authors: I
authors: Janssen
authors: Marie-France
authors: MF
authors: Langlois
authors: Jean-Patrice
authors: JP
authors: Baillargeon
authors: Caroline S
authors: CS
authors: Fox
authors: James B
authors: JB
authors: Meigs
authors: Ralph B
authors: RB
authors: D'Agostino
authors: Michael
authors: M
authors: Pencina
authors: Marie-France
authors: MF
authors: Hivert
mesh_terms: D000328:Adult; D032721:Adult Children; D000367:Age Factors; D015992:Body Mass Index; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008954:Models, Biological; D009765:Obesity / Q000503:physiopathology*; D050177:Overweight / Q000503:physiopathology*; D011446:Prospective Studies; D012307:Risk Factors; D015430:Weight Gain