title: SIOP-PODC recommendations for graduated-intensity treatment of retinoblastoma in developing countries.
abstract: Retinoblastoma remains incurable in many regions of the world. The major obstacles to cure are delayed diagnosis, poor treatment compliance, and lack of evidence-based recommendations for clinical management. Although enucleation is curative for intraocular disease, in developing countries retinoblastoma is often diagnosed after the disease has disseminated beyond the eye. A SIOP-PODC committee generated guidelines for the clinical management of retinoblastoma in developing countries and developed a classification system based on the resources available in those settings. Recommendations are provided for staging and treatment of unilateral and bilateral retinoblastoma and counseling of families for whom compliance is an issue.
authors: Hospital de Pediatria SAMIC Prof Dr Juan P Garrahan, Buenos Aires, Argentina. gchantada@yahoo.com
authors: Guillermo
authors: G
authors: Chantada
authors: Sandra
authors: S
authors: Luna-Fineman
authors: Rita S
authors: RS
authors: Sitorus
authors: Mariana
authors: M
authors: Kruger
authors: Trijn
authors: T
authors: Israels
authors: Carlos
authors: C
authors: Leal-Leal
authors: Sameer
authors: S
authors: Bakhshi
authors: Ibrahim
authors: I
authors: Qaddoumi
authors: David H
authors: DH
authors: Abramson
authors: François
authors: F
authors: Doz
mesh_terms: D003131:Combined Modality Therapy; D003906:Developing Countries; D006297:Health Services Accessibility; D006801:Humans; D009367:Neoplasm Staging; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000628:therapy*; D012175:Retinoblastoma / Q000175:diagnosis* / Q000628:therapy*; D018570:Risk Assessment; D016896:Treatment Outcome; D016312:Treatment Refusal