title: The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: a study of 53 cases.
abstract: Current laboratory technics, clinicopathologic findings cannot always reliably distinguish primary cutaneous CD30(+) lymphoproliferative disorders (LPD), such as lymphomatoid papulosis (LyP), primary cutaneous CD30(+) anaplastic large cell lymphoma (PCALCL), transformed mycosis fungoides (T-MF) and systemic ALK(-) anaplastic large cell lymphoma (ALCL) with skin involvement. We investigated the presence of IRF4 translocation with break apart DNA-FISH method of these entities according to the recent studies of Feldman et al. In our study group with 53 cases, the detection of IRF4 translocation had a specificity and positive predictive value for PCALCL of 100%. In contrast MUM1/IRF4 protein expression was distributed widely without any predictive value.
authors: Department of Pathology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey. tugceesen@msn.com
authors: Tugce
authors: T
authors: Kiran
authors: Cuyan
authors: C
authors: Demirkesen
authors: Candan
authors: C
authors: Eker
authors: Hakki
authors: H
authors: Kumusoglu
authors: Nukhet
authors: N
authors: Tuzuner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D050835:Interferon Regulatory Factors / Q000378:metabolism*; D017730:Ki-1 Antigen / Q000378:metabolism*; D008232:Lymphoproliferative Disorders / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D021381:Protein Transport; D012878:Skin Neoplasms / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*; D055815:Young Adult; D000099218:Interferon Regulatory Factor-4
chemical_list: D050835:Interferon Regulatory Factors; D017730:Ki-1 Antigen; D000099218:Interferon Regulatory Factor-4