title: Distribution and heritability of peripheral eye length in Chinese children and adolescents: the Guangzhou Twin Eye Study.
abstract: OBJECTIVE
  Peripheral eye length (PEL) provides a measure of overall eye shape, which may play a role in the development of myopia. The current study explores the distribution and heritability of PEL, relative PEL (RPEL, defined as PEL minus axial eye length) and relative ratio PEL (RRPEL, defined as PEL divided by axial eye length) in Chinese children and adolescents.
  
  
  METHODS
  Subjects included both male and female youths participating in the Guangzhou Twin Eye Study. Eye length was measured by partial coherence laser interferometry axially, 40° temporally (PEL-T(40)) and 40° nasally (PEL-N(40)). Structural equation modeling (SEM) was used to estimate the relative contribution of genetic and environmental factors on PEL, RPEL, and RRPEL, adjusting for age and sex.
  
  
  RESULTS
  We examined 104 monozygotic (MZ) and 54 dizygotic (DZ) twins aged 8 to 20 years old. The intraclass correlation coefficients were 0.89 for PEL-T(40), 0.92 for PEL-N(40), 0.80 for RPEL-T(40), 0.73 for RPEL-N(40), 0.77 for RRPEL-T(40), and 0.73 for RRPEL-N(40) in MZ pairs, and 0.52, 0.50, 0.39, 0.58, 0.37, and 0.58 in DZ pairs, respectively. The best fit adjusted models estimated that additive genetic effects accounted for approximately 86.2%, 89.8%, 79.9%, 75.5%, 77.1%, and 74.5% of the variance for the above mentioned traits, respectively, while dominant genetic effects and shared environmental factors were negligible.
  
  
  CONCLUSIONS
  Additive genetic effects had a substantial influence on phenotypic variation in PEL and RPEL, suggesting genetic rather than environmental factors play a major role in determining eye shape.
authors: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
authors: Xiaohu
authors: X
authors: Ding
authors: Decai
authors: D
authors: Wang
authors: Qunxiao
authors: Q
authors: Huang
authors: Jian
authors: J
authors: Zhang
authors: Jessica
authors: J
authors: Chang
authors: Mingguang
authors: M
authors: He
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics*; D002648:Child; D002681:China; D005260:Female; D006801:Humans; D007498:Iris / Q000166:cytology*; D008297:Male; D019655:Quantitative Trait, Heritable; D012029:Refraction, Ocular / Q000235:genetics*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014429:Twins, Dizygotic / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*