title: Sequential [6+2], [2+2], and [3+2] annulations for rapid assembly of multiple fragments.
abstract: Assembly of four components through sequential [6+2], [2+2], and [3+2] annulations on an azulenone manifold allows for five-step access to a natural product-inspired scaffold with exquisite control of the ten consecutive stereocenters. X-ray analysis was used to define the spatial arrangement of the three fragments and functional groups on this rigid scaffold.
authors: Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan.
authors: Velisoju
authors: V
authors: Mahendar
authors: Hideaki
authors: H
authors: Oikawa
authors: Hiroki
authors: H
authors: Oguri
mesh_terms: D052176:Azulenes / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry*; D018360:Crystallography, X-Ray; D061565:Cycloaddition Reaction; D015195:Drug Design; D008968:Molecular Conformation; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry
chemical_list: D052176:Azulenes; D001688:Biological Products; D013729:Terpenes