title: Gallic acid decreases vacuous chewing movements induced by reserpine in rats.
abstract: Involuntary oral movements are present in several diseases and pharmacological conditions; however, their etiology and efficient treatments remain unclear. Gallic acid is a natural polyphenolic acid found in gall nuts, sumac, oak bark, tea leaves, grapes and wine, with potent antioxidant and antiapoptotic activity. Thus, the present study investigated the effects of gallic acid on vacuous chewing movements (VCMs) in an animal model induced by reserpine. Rats received either vehicle or reserpine (1mg/kg/day, s.c.) during three days, followed by treatment with water or different doses of gallic acid (4.5, 13.5 or 40.5mg/kg/day, p.o.) for three more days. As result, reserpine increased the number of VCMs in rats, and this effect was maintained for at least three days after its withdrawal. Gallic acid at two different doses (13.5 and 40.5mg/kg/day) has reduced VCMs in rats previously treated with reserpine. Furthermore, we investigated oxidative stress parameters (DCFH-DA oxidation, TBARS and thiol levels) and Na(+),K(+)-ATPase activity in striatum and cerebral cortex, however, no changes were observed. These findings show that gallic acid may have promissory use in the treatment of involuntary oral movements.
authors: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil.
authors: Patrícia
authors: P
authors: Reckziegel
authors: Luis Ricardo
authors: LR
authors: Peroza
authors: Larissa Finger
authors: LF
authors: Schaffer
authors: Mayara Calegaro
authors: MC
authors: Ferrari
authors: Catiuscia Molz
authors: CM
authors: de Freitas
authors: Marilise Escobar
authors: ME
authors: Bürger
authors: Roselei
authors: R
authors: Fachinetto
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000633:toxicity; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000633:toxicity; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004195:Disease Models, Animal; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000503:physiopathology; D005707:Gallic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008409:Mastication / Q000187:drug effects* / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000633:toxicity*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D018759:Adrenergic Uptake Inhibitors; D000975:Antioxidants; D014150:Antipsychotic Agents; D005707:Gallic Acid; D012110:Reserpine; D000254:Sodium-Potassium-Exchanging ATPase