title: Postpartum persistent proteinuria after preeclampsia: a single-center experience.
abstract: BACKGROUND
  Many studies have investigated preexistent renal disease during pregnancy. However, insufficient data regarding the new onset of glomerulonephritis in the course of gestation, especially in patients with preeclampsia, exist. The aim of this study was to investigate underlying renal disease in preeclamptic Turkish women with persistent proteinuria after delivery.
  
  
  METHODS
  Between 2005 and 2010, 463 patients with preeclampsia were admitted to our hospital. The symptoms of proteinuria persisted in 34 women (0.7 %). Thirteen of these patients refused a kidney biopsy. Seven of these patients had a history of documented kidney disease. Kidney biopsies were performed on 14 women who were diagnosed with persistent proteinuria in the postpartum period and the specimens were examined by light and immunofluorescence microscopy.
  
  
  RESULTS
  Ten of 14 patients (71 %) were diagnosed with underlying renal disease. Four patients were diagnosed with idiopathic preeclampsia (29 %). Histopathological findings existed for ten patients with underlying renal disease; four patients (29 %) were diagnosed with membranoproliferative glomerulonephritis (MPGN), four patients (29 %) were diagnosed with IgA nephropathy (IgAN), one patient (7 %) was diagnosed with focal segmental glomerulosclerosis (FSGS), and one patient (7 %) was diagnosed with amyloidosis. Hematuria was detected in eight patients (57 %), and high serum creatinin levels were observed in five (36 %).
  
  
  CONCLUSIONS
  Persistent proteinuria is the most important predictor of underlying renal disease after delivery. All patients with preeclampsia should be evaluated with respect to continuing proteinuria, persistent hematuria, or impaired renal functions after postpartum period and a percutaneous renal biopsy should be performed in those patients who have positive signs of underlying renal disease.
authors: Department of Nephrology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Selman
authors: S
authors: Unverdi
authors: Mevlut
authors: M
authors: Ceri
authors: Hatice
authors: H
authors: Unverdi
authors: Rahmi
authors: R
authors: Yilmaz
authors: Ali
authors: A
authors: Akcay
authors: Murat
authors: M
authors: Duranay
mesh_terms: D000328:Adult; D015984:Causality; D002908:Chronic Disease; D015897:Comorbidity; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000453:epidemiology*; D011247:Pregnancy; D015995:Prevalence; D011379:Prognosis; D011507:Proteinuria / Q000175:diagnosis / Q000453:epidemiology*; D018570:Risk Assessment; D014421:Turkey / Q000453:epidemiology