title: Surgical implications of the potential new tubal pathway for ovarian carcinogenesis.
abstract: Since 2001, many studies by different investigators have demonstrated that the fallopian tube might be at the origin of most high-grade ovarian and peritoneal serous carcinomas. Simple changes in surgical practice (ie, prophylactic bilateral salpingectomy instead of salpingo-oophorectomy) could have significant implications for death from ovarian cancer and, on the other hand, for the morbidity caused by ovariectomy (surgical menopause). In this review, we describe the new tubal carcinogenic sequence, the advantages and disadvantages of exclusive use of salpingectomy in the general population, and in cases of hereditary predisposition to ovarian cancer such as for carriers of BRCA mutation.
authors: Research Centre of the University of Montreal Hospital Centre (CRCHUM), Montreal Cancer Institute, Montreal, Quebec, Canada. chenegautier@yahoo.fr
authors: Gautier
authors: G
authors: Chene
authors: Kourosh
authors: K
authors: Rahimi
authors: Ann-Marie
authors: AM
authors: Mes-Masson
authors: Diane
authors: D
authors: Provencher
mesh_terms: D002278:Carcinoma in Situ / Q000235:genetics / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D005185:Fallopian Tube Neoplasms / Q000235:genetics / Q000473:pathology*; D005187:Fallopian Tubes / Q000473:pathology*; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology* / Q000517:prevention & control*; D058994:Salpingectomy