title: Mucin-type O-glycosylation during development.
abstract: Mucin-type O-glycosylation is an evolutionarily conserved protein modification present on membrane-bound and secreted proteins. Aberrations in O-glycosylation are responsible for certain human diseases and are associated with disease risk factors. Recent studies have demonstrated essential roles for mucin-type O-glycosylation in protein secretion, stability, processing, and function. Here, we summarize our current understanding of the diverse roles of mucin-type O-glycosylation during eukaryotic development. Appreciating how this conserved modification operates in developmental processes will provide insight into its roles in human disease and disease susceptibilities.
authors: Developmental Glycobiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892-4370, USA.
authors: Duy T
authors: DT
authors: Tran
authors: Kelly G
authors: KG
authors: Ten Hagen
mesh_terms: D000116:Acetylgalactosamine / Q000378:metabolism; D000818:Animals; D006031:Glycosylation; D016695:Glycosyltransferases / Q000378:metabolism*; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008954:Models, Biological; D009077:Mucins / Q000378:metabolism*; D017350:N-Acetylgalactosaminyltransferases / Q000378:metabolism; D011134:Polysaccharides / Q000378:metabolism*
chemical_list: D008562:Membrane Glycoproteins; D009077:Mucins; D011134:Polysaccharides; D016695:Glycosyltransferases; D017350:N-Acetylgalactosaminyltransferases; D000116:Acetylgalactosamine