title: Comparative study of pelvic floor biofeedback training and tolterodine for treatment of detrusor after-contraction in posturination dribbling in children.
abstract: OBJECTIVE
  To investigate the prevalence of detrusor after-contraction (DA-C) in children with posturination dribbling, and compare the outcomes of pharmacological treatment and pelvic floor biofeedback training.
  
  
  METHODS
  Children with posturination dribbling underwent urodynamic studies.  Patients with DA-C were randomly allocated to one of two groups: pelvic floor biofeedback training or 1 mg tolterodine, orally, twice daily. Treatment was continued for 12 weeks.
  
  
  RESULTS
  The study included 45 children. DA-C was present in 39 patients (86.6%), 30 (76.9%) of whom also exhibited  detrusor overactivity. Pelvic floor biofeedback training resulted in a significantly better response than tolterodine, in terms of reduction in the number of posturination dribbling events in the month after completion of treatment.
  
  
  CONCLUSIONS
  DA-C is closely associated with posturination  dribbling in children. Pelvic floor biofeedback training should be considered the initial treatment option in these patients.
authors: Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors: F
authors: F
authors: Zeng
authors: H Q
authors: HQ
authors: Chen
authors: L
authors: L
authors: Qi
authors: X Y
authors: XY
authors: Zhang
authors: Y
authors: Y
authors: Li
mesh_terms: D000293:Adolescent; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D001676:Biofeedback, Psychology; D002648:Child; D003408:Cresols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000503:physiopathology; D017773:Pelvic Floor; D010665:Phenylpropanolamine / Q000627:therapeutic use*; D000068737:Tolterodine Tartrate; D001743:Urinary Bladder; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*; D014549:Urinary Incontinence / Q000188:drug therapy* / Q000209:etiology; D014563:Urodynamics
chemical_list: D001559:Benzhydryl Compounds; D003408:Cresols; D018727:Muscarinic Antagonists; D010665:Phenylpropanolamine; D000068737:Tolterodine Tartrate