title: Cortical sources of resting state EEG rhythms are sensitive to the progression of early stage Alzheimer's disease.
abstract: Cortical sources of resting state electroencephalographic (EEG) rhythms are abnormal in subjects with Alzheimer's disease (AD). Here we tested the hypothesis that these sources are also sensitive to the progression of early stage AD over the course of one year. The resting state eyes-closed EEG data were recorded in 88 mild AD patients at baseline (Mini Mental State Evaluation, MMSE I = 21.7 ± 0.2 standard error, SE) and at approximately one-year follow up (13.3 months ± 0.5 SE; MMSE II = 20 ± 0.4 SE). All patients received standard therapy with acetylcholinesterase inhibitors. EEG recordings were also performed in 35 normal elderly (Nold) subjects as controls. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz). Cortical EEG sources were estimated by low-resolution brain electromagnetic tomography (LORETA). Compared to the Nold subjects, the mild AD patients were characterized by a power increase of widespread delta sources and by a power decrease of posterior alpha sources. In the mild AD patients, the follow-up EEG recordings showed increased power of widespread delta sources as well as decreased power of widespread alpha and posterior beta 1 sources. These results suggest that the resting state EEG sources were sensitive, at least at group level, to the cognitive decline occurring in the mild AD group over a one-year period, and might represent cost-effective and non-invasive markers with which to enrich cohorts of AD patients that decline faster for clinical studies.
authors: Department of Molecular Medicine, University of Rome "Sapienza", Rome, Italy IRCCS San Raffaele Pisana, Roma, Italy. claudio.babiloni@uniroma1.it
authors: Claudio
authors: C
authors: Babiloni
authors: Roberta
authors: R
authors: Lizio
authors: Claudio
authors: C
authors: Del Percio
authors: Nicola
authors: N
authors: Marzano
authors: Andrea
authors: A
authors: Soricelli
authors: Elena
authors: E
authors: Salvatore
authors: Raffaele
authors: R
authors: Ferri
authors: Filomena I I
authors: FI
authors: Cosentino
authors: Gioacchino
authors: G
authors: Tedeschi
authors: Patrizia
authors: P
authors: Montella
authors: Silvia
authors: S
authors: Marino
authors: Simona
authors: S
authors: De Salvo
authors: Guido
authors: G
authors: Rodriguez
authors: Flavio
authors: F
authors: Nobili
authors: Fabrizio
authors: F
authors: Vernieri
authors: Francesca
authors: F
authors: Ursini
authors: Ciro
authors: C
authors: Mundi
authors: Jill C
authors: JC
authors: Richardson
authors: Giovanni B
authors: GB
authors: Frisoni
authors: Paolo M
authors: PM
authors: Rossini
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D000704:Analysis of Variance; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D018450:Disease Progression; D004569:Electroencephalography; D004585:Electrooculography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013058:Mass Spectrometry; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D010507:Periodicity; D012146:Rest / Q000502:physiology*; D012680:Sensitivity and Specificity
chemical_list: D002800:Cholinesterase Inhibitors