title: Anxiolytic actions of motilin in the basolateral amygdala.
abstract: Motilin is a 22-amino-acid gastrointestinal polypeptide that was first isolated from the porcine intestine. We identified that motilin receptor is highly expressed in GABAergic interneurons in the basolateral nucleus (BLA) of the amygdala, the structure of which is closely involved in assigning stress disorder and anxiety. However, little is known about the role of motilin in BLA neuronal circuits and the molecular mechanisms of stress-related anxiety. Whole-cell recordings from amygdala slices showed that motilin depolarized the interneurons and facilitated GABAergic transmission in the BLA, which is mimicked by the motilin receptor agonist, erythromycin. BLA local injection of erythromycin or motilin can reduce the anxiety-like behavior in mice after acute stress. Therefore, motilin is essential in regulating interneuron excitability and GABAergic transmission in BLA. Moreover, the anxiolytic actions of motilin can partly be explained by modulating the BLA neuronal circuits. The present data demonstrate the importance of motilin in anxiety and the development of motilin receptor non-peptide agonist as a clear target for the potential treatment of anxiety disorders.
authors: Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an 710032, China.
authors: Bin
authors: B
authors: Feng
authors: Jin-Cheng
authors: JC
authors: Liu
authors: Jun
authors: J
authors: Zhang
authors: Ken-Ichi
authors: K
authors: Ozaki
authors: Yan-Yan
authors: YY
authors: Guo
authors: Ding-Hua
authors: DH
authors: Yi
authors: Xiao-Qiang
authors: XQ
authors: Li
authors: Ming-Gao
authors: MG
authors: Zhao
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000679:Amygdala / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D019706:Excitatory Postsynaptic Potentials; D059330:GABAergic Neurons / Q000378:metabolism / Q000473:pathology; D005971:Glutamates / Q000378:metabolism; D053444:Inhibitory Postsynaptic Potentials; D008297:Male; D018782:Maze Learning; D051379:Mice; D008807:Mice, Inbred BALB C; D009037:Motilin / Q000378:metabolism*; D011964:Receptors, Gastrointestinal Hormone / Q000378:metabolism; D018013:Receptors, Neuropeptide / Q000378:metabolism; D013312:Stress, Physiological / Q000187:drug effects; D013550:Swimming; D013569:Synapses / Q000187:drug effects / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D014151:Anti-Anxiety Agents; D005971:Glutamates; D011964:Receptors, Gastrointestinal Hormone; D018013:Receptors, Neuropeptide; C050802:motilin receptor; D009037:Motilin; D005680:gamma-Aminobutyric Acid