title: Building silent compartments at the nuclear periphery: a recurrent theme.
abstract: In eukaryotes, the genetic material is stored in the nucleus, which is enclosed in a double lipid bilayer, the nuclear envelope (NE). It protects the genome from physical stress and separates it from the rest of the cell. On top of this physical function, growing evidence shows that the nuclear periphery contributes to the 3D organization of the genome. In turn, tridimensional organization of chromatin in the nuclear space influences genome expression. Here we review recent findings on the function of this physical barrier in gene repression and latest models on how silent subnuclear compartments at the NE are built in yeast as well as in the nematode C. elegans and mammalian cells; trying to draw parallels between the three systems.
authors: Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland. peter.meister@izb.unibe.ch
authors: Peter
authors: P
authors: Meister
authors: Angela
authors: A
authors: Taddei
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics*; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D042822:Genomic Instability; D006801:Humans; D009685:Nuclear Envelope / Q000235:genetics* / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics
chemical_list: D002843:Chromatin; D009687:Nuclear Proteins