title: An access to aza-Freidinger lactams and E-locked analogs.
abstract: Freidinger lactams, possessing a peptide bond configuration locked to Z, are important key elements of conformationally restricted peptidomimetics. In the present work, the C(α)H(i+1) unit has been replaced by N, leading to novel aza-Freidinger lactams. A synthesis to corresponding building blocks and their E-locked analogs is introduced. The versatile buildings blocks reported here are expected to serve as useful elements in peptide synthesis.
authors: Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
authors: Philipp A
authors: PA
authors: Ottersbach
authors: Janina
authors: J
authors: Schmitz
authors: Gregor
authors: G
authors: Schnakenburg
authors: Michael
authors: M
authors: Gütschow
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D057056:Cysteine Proteases / Q000187:drug effects; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds; D007769:Lactams; D010455:Peptides; D057056:Cysteine Proteases