title: Exercise maintains sexual activity in men undergoing androgen suppression for prostate cancer: a randomized controlled trial.
abstract: BACKGROUND
  Previous research has shown exercise to be an effective method to mitigate many adverse treatment-related effects of androgen suppression therapy (AST) but the potential impact of exercise on sexual activity remains unknown. The purpose of this investigation was to report the effect of a 12-week exercise program on sexual activity in prostate cancer patients undergoing AST.
  
  
  METHODS
  Fifty-seven prostate cancer patients undergoing AST were randomly assigned to an exercise program (resistance and aerobic modes; n=29) or usual care control (n=28). Sexual activity was assessed by the European Organization for Research and Treatment of Cancer prostate cancer-specific quality of life questionnaire (QLQ-PR25).
  
  
  RESULTS
  QLQ-PR25 data were log transformed and analysis of covariance was used to compare sexual activity between groups following the intervention adjusted for baseline activity. No differences in sexual activity were observed between the exercise and control groups before the intervention. There was a significant (P=0.045) adjusted group difference in sexual activity following the 12-week intervention. Patients undergoing usual care decreased sexual activity while patients in the exercise program maintained their level of sexual activity. At baseline, 20.6 and 22.2% of participants in the exercise and control groups reported a major interest in sex (that is, high libido). Following the intervention, the exercise group had a significantly higher percentage of participants reporting a major interest in sex (exercise=17.2% vs control=0%; P=0.024).
  
  
  CONCLUSIONS
  Participation in a short-term exercise program resulted in the maintenance of sexual activity in prostate cancer patients undergoing AST.
authors: Edith Cowan University Health and Wellness Institute, Edith Cowan University, Joondalup, Western Australia, Australia. p.cormie@ecu.edu.au
authors: P
authors: P
authors: Cormie
authors: R U
authors: RU
authors: Newton
authors: D R
authors: DR
authors: Taaffe
authors: N
authors: N
authors: Spry
authors: D
authors: D
authors: Joseph
authors: M
authors: M
authors: Akhlil Hamid
authors: D A
authors: DA
authors: Galvão
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005081:Exercise Therapy; D006801:Humans; D007610:Kallikreins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000097:blood / Q000628:therapy; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000628:therapy*; D011788:Quality of Life; D012725:Sexual Behavior; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood; D016896:Treatment Outcome
chemical_list: D013739:Testosterone; C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen