title: Role of CXCR2 on the immune modulating activity of α-iso-cubebenol a natural compound isolated from the Schisandra chinensis fruit.
abstract: Previously, we demonstrated that α-iso-cubebenol, a natural compound isolated from the fruits of Schisandra chinensis, strongly enhances therapeutic efficacy against cecal ligation and puncture challenge-induced sepsis. In this study, we found that α-iso-cubebenol stimulated calcium increase and degranulation in human neutrophils. α-Iso-cubebenol also strongly induced neutrophil chemotaxis, which was completely blocked by a CXCR2 antagonist, SB225002. The increased survival rate by α-iso-cubebenol was also significantly attenuated by SB225002. Taken together, the results indicate that α-iso-cubebenol-induced anti-septic activity was mediated by CXCR2, suggesting CXCR2 as an important target for the regulation of sepsis and inflammation.
authors: Department of Biological Science, Sungkyunkwan University, Suwon 440-746, South Korea.
authors: Young Su
authors: YS
authors: Jung
authors: Sung Kyun
authors: SK
authors: Lee
authors: Chang Youp
authors: CY
authors: Ok
authors: Eun Jung
authors: EJ
authors: Cho
authors: Joon Seong
authors: JS
authors: Park
authors: Young Whan
authors: YW
authors: Choi
authors: Yoe-Sik
authors: YS
authors: Bae
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D015550:Cell Degranulation / Q000187:drug effects / Q000276:immunology; D002633:Chemotaxis / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010671:Phenylurea Compounds / Q000494:pharmacology; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors / Q000502:physiology*; D032141:Schisandra / Q000737:chemistry*; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D007155:Immunologic Factors; D010671:Phenylurea Compounds; D023063:Receptors, Interleukin-8B; C112019:SB 225002; D012717:Sesquiterpenes; C571662:alpha-iso-cubebenol; D002118:Calcium