title: Mesoporous silica nanoparticle facilitated drug release through cascade photosensitizer activation and cleavage of singlet oxygen sensitive linker.
abstract: A photoresponsive drug releasing system based on mesoporous silica nanoparticles (MSN) was developed. A model drug was decorated on the surfaces via singlet oxygen sensitive linkers and a singlet oxygen-generating photosensitizer was loaded in the mesopores of the MSN. An on-demand drug releasing system was successfully developed by irradiation with long-wavelength light.
authors: Department of Chemistry, Center for Self-assembly and Complexity, Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang, 790-784, Republic of Korea.
authors: Junseok
authors: J
authors: Lee
authors: Juhee
authors: J
authors: Park
authors: Kaushik
authors: K
authors: Singha
authors: Won Jong
authors: WJ
authors: Kim
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry; D054833:Isoindoles; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D017319:Photosensitizing Agents / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry*; D017967:Zinc Compounds
chemical_list: D004337:Drug Carriers; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D026082:Singlet Oxygen; D012822:Silicon Dioxide