title: [Study on the association between RANTES-403G/A as well as -28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou, China].
abstract: OBJECTIVE
  To investigate the association between both regulated upon activation normal T cell expressed and secreted (RANTES) -403G/A, -28C/G gene polymorphism and the susceptibilities to hepatitis B virus (HBV) infection, among people with Dong and Han ethnicities, in Guizhou.
  
  
  METHODS
  A total of 229 individuals with HBV persistence infection, 161 HBV clearanced patients and another 200 controls were recruited to conduct a case-control study among residents with Dong or Han ethnicities. Allelic frequencies of both RANTES-403G/A and -28C/G were identified by TaqMan-MGB probe.
  
  
  RESULTS
  Both RANTES-403G/A and -28C/G polymorphism in the HBV-persistent group, when compared to the HBV-clearances group, no significant difference was found (P > 0.05).
  
  
  RESULTS
  from the univariate analysis showed that subjects carrying -403AG and -28GG genotype had higher risk on the susceptibility to HBV persistence infection. The distributions of RANTES-28C/G gene polymorphism between Dong minority and Han ethnicities regarding HBV persistence showed statistically significant difference (P < 0.05). There was no difference on the distributions of RANTES-403G/A gene polymorphism between Dong minority and Han ethnicities.
  
  
  CONCLUSIONS
  Patients that carrying both RANTES-403AG and -28GG genotype had higher risk on the persistence to HBV, while RANTES-403A had contributed to the clearance of HBV infection.
authors: Reproductive IVF Center of Luoyang Central Hospital, Luoyang 471002, China.
authors: Chan
authors: C
authors: Zhang
authors: Ke-ren
authors: KR
authors: Shan
authors: Yan
authors: Y
authors: He
authors: Chan-juan
authors: CJ
authors: Wang
authors: Ting
authors: T
authors: Zhang
authors: Yi
authors: Y
authors: Li
authors: Jie
authors: J
authors: Deng
authors: Lin-jie
authors: LJ
authors: Li
authors: Kai
authors: K
authors: Ouyang
authors: Zhi-zhong
authors: ZZ
authors: Guan
mesh_terms: D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006509:Hepatitis B / Q000453:epidemiology* / Q000235:genetics*; D006515:Hepatitis B virus; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: C483024:CCL5 protein, human; D018946:Chemokine CCL5