title: Peutz-Jegher syndrome in childhood: need for updated recommendations?
abstract: OBJECTIVE
  We reviewed our institution's experience with Peutz-Jegher syndrome (PJS) in children to determine whether current recommendations on timing of screening and follow-up should be modified.
  
  
  METHODS
  We reviewed the charts of all of the children with a diagnosis of PJS at our institution from 2000 to 2011 abstracting data on intussusceptions events, polyp characteristics, Sertoli cell (SC) tumors, family history, imaging, and interventions.
  
  
  RESULTS
  Of 14 children identified, 10 were boys. Median age at first clinical evaluation was 4.5 years, and family history and/or mucocutaneous pigmentation were the 2 most common factors stimulating screening. Median age at first screening test was 5 years (range 1-16), and at first polyp identification, 5 years (range 1 to 18). There were 7 intussusception events in 5 children, with median age of 10 and range 5 to 16 for first event. Two boys had SC tumors at 8 and 11 years. Polyps were identified during initial screening in 9 of 14 patients. Polyps were found in the stomach or duodenum in 5 (36%), small bowel in 7, (50%) and colon in 3 (21%) children. Large polyps were identified in 9 children at median age of 7 years.
  
  
  CONCLUSIONS
  Polyps causing significant clinical consequences can occur frequently in children with PJS younger than 8 years. Revised guidelines should consider initial screening at age 4 to 5 with capsule endoscopy and upper and lower endoscopy as well as evaluation for SC tumors and re-evaluation whenever symptoms suggest polyp-associated complications.
authors: University of Colorado School of Medicine, Aurora, CO, USA.
authors: Stephanie A
authors: SA
authors: Goldstein
authors: Edward J
authors: EJ
authors: Hoffenberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D053704:Capsule Endoscopy; D002648:Child; D002675:Child, Preschool; D003106:Colon / Q000473:pathology; D005190:Family; D005260:Female; D041981:Gastrointestinal Tract / Q000473:pathology*; D006801:Humans; D007417:Intestinal Polyps / Q000175:diagnosis* / Q000209:etiology; D007421:Intestine, Small / Q000473:pathology; D007443:Intussusception / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D008297:Male; D010580:Peutz-Jeghers Syndrome / Q000473:pathology*; D010858:Pigmentation; D012707:Sertoli Cell Tumor / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D012708:Sertoli Cells / Q000473:pathology; D012737:Sex Factors; D013270:Stomach / Q000473:pathology; D055815:Young Adult