title: Dedifferentiation, transdifferentiation, and reprogramming: future directions in regenerative medicine.
abstract: The main goal of regenerative medicine is to replace damaged tissue. To do this it is necessary to understand in detail the whole regeneration process including differentiated cells that can be converted into progenitor cells (dedifferentiation), cells that can switch into another cell type (transdifferentiation), and somatic cells that can be induced to become pluripotent cells (reprogramming). By studying the regenerative processes in both nonmammal and mammal models, natural or artificial processes could underscore the molecular and cellular mechanisms behind these phenomena and be used to create future regenerative strategies for humans.
authors: Center for Regenerative Medicine in Barcelona.
authors: Cristina
authors: C
authors: Eguizabal
authors: Nuria
authors: N
authors: Montserrat
authors: Anna
authors: A
authors: Veiga
authors: Juan Carlos
authors: JC
authors: Izpisua Belmonte
mesh_terms: D054337:Cell Dedifferentiation / Q000502:physiology; D054338:Cell Transdifferentiation / Q000502:physiology; D065150:Cellular Reprogramming / Q000502:physiology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000502:physiology; D044968:Regenerative Medicine / Q000379:methods*