title: Novel biodegradable electrospun nanofibrous P(DLLA-CL) balloons for the treatment of vertebral compression fractures.
abstract: Significant interest has been expressed by the spinal surgeon community for the use of calcium phosphate cement (CPC) in the treatment of vertebral compression fractures (VCFs), but the water-induced collapsibility and poor mechanical properties limit its clinical use. Here we fabricated novel electrospun nanofibrous P(DLLA-CL) balloons (ENPBs) using the nanotechnique of electrospinning. The ENPBs could separate the cements from the surrounding environment, and therefore can prevent the water-induced collapsibility of CPC and eliminate cement leakage. The ENPBs filling with CPC had enough load-bearing ability to restore the height of the fractured vertebral body and had no obvious effects on the initial strength and stiffness of natural bones. Further, the ENPBs had good biodegradability and cell proliferation ability. Calcium can be released from ENPBs filling with CPC. All these results strongly demonstrate ENPBs can be potentially used as CPC filling containers that keep the advantages and eliminate the disadvantages of CPC.
  
  
  BACKGROUND
  Calcium phosphate cement (CPC) is a promising modality in vertebral compression fracture treatment, but its water-induced collapsibility limits clinical applications. This team of investigators fabricated novel nanofibrous balloons using electrospinning, which enabled the separation of CPC from its surrounding environment, and therefore prevented water-induced collapsibility of CPC and eliminated cement leakage while maintaining all the advantages of CPC treatment.
authors: Department of Medical Imaging, Jinan Military General Hospital, No. 25 Shifan Road, Jinan, Shandong Province, People's Republic of China. cjr.sungang@vip.163.com
authors: Gang
authors: G
authors: Sun
authors: Daixu
authors: D
authors: Wei
authors: Xunwei
authors: X
authors: Liu
authors: Yuyun
authors: Y
authors: Chen
authors: Min
authors: M
authors: Li
authors: Dannong
authors: D
authors: He
authors: Jian
authors: J
authors: Zhong
mesh_terms: D001843:Bone Cements / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D049109:Cell Proliferation; D050815:Fractures, Compression / Q000473:pathology / Q000628:therapy*; D006801:Humans; D058498:Kyphoplasty; D057139:Nanofibers / Q000737:chemistry / Q000627:therapeutic use*; D016103:Spinal Fractures / Q000628:therapy*; D014867:Water / Q000737:chemistry
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D014867:Water
keywords: Biodegradable electrospun nanofibrous P(DLLA-CL) balloon; Biomechanics; Calcium phosphate cement; Scaffolds; Vertebral compression fractures