title: Increased levels of mean platelet volume: a possible relationship with idiopathic sudden hearing loss.
abstract: Mean platelet volume (MPV) is one of the platelet function indices which reflects the platelet production rate and functions. While vascular occlusion, acute or chronic syndromes and vasculitis are increasing the MPV levels, infections, autoimmune diseases, and inflammatory situations reduce it. The indicator for idiopathic sudden sensorineural hearing loss (ISHL) etiology remains a matter of debate because it is associated with many different disorders. We evaluated MPV levels in ISHL patients. Forty patients with ISHL and 40 healthy, age and sex matched subjects were enrolled to the study. Audiometer and laboratory results were recorded. Comparative multivariate analyses between indicator factors and hearing outcomes were conducted. MPV and platelet distribution width is significantly higher in ISHL. Platelet count is lower in the ISHL than control group (p < 0.001), (p < 0.001), (p = 0.003), respectively. Our findings indicate that, ISHL appears to be characterized by ischaemic or thrombotic events. Considering the increased MPV levels; MPV may be used to evaluate ISHL as an hepler indicator.
authors: Department of Otolaryngology, Faculty of Medicine, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey, drsahinulu@yahoo.com.
authors: Sahin
authors: S
authors: Ulu
authors: M Sena
authors: MS
authors: Ulu
authors: Ahmet
authors: A
authors: Ahsen
authors: Fatih
authors: F
authors: Yucedag
authors: Abdullah
authors: A
authors: Aycicek
authors: Sefa
authors: S
authors: Celik
mesh_terms: D000328:Adult; D001299:Audiometry; D016022:Case-Control Studies; D005260:Female; D003639:Hearing Loss, Sudden / Q000097:blood*; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015999:Multivariate Analysis; D010976:Platelet Count