title: Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer.
abstract: In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-κB/IL-6/STAT3 pathway. This appears critical for progression from chronic inflammation to colon cancer.
authors: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK. n.j.pyne@strath.ac.uk
authors: Nigel J
authors: NJ
authors: Pyne
authors: Susan
authors: S
authors: Pyne