title: A complicated case of anticoagulation.
abstract: In this case of complex anticoagulation, a 60-year-old woman was treated with low-molecular-weight heparin for pulmonary embolism. As a result of anticoagulation, she then developed an acute subdural haemorrhage identified on CT brain scan requiring craniectomy. Subsequently, while continuing anticoagulation for treatment for pulmonary embolism, she additionally had a large intra-abdominal bleed within and around the psoas muscle identified on abdominal CT scan. Although the increased risk of bleeding is known with anticoagulation therapy, the case of both an intracerebral and intra-abdominal bleed is rare. However, the case does highlight how each individual has a unique physiological response to anticoagulation, in some cases more severe than others.
authors: Department of General Medicine, Queen's Hospital Romford, Essex, UK. rooshi_n@hotmail.com
authors: Rooshi
authors: R
authors: Nathwani
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001777:Blood Coagulation; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D014859:Warfarin