title: Basal insulin requirements after progesterone treatment in a type 1 diabetic pregnant woman.
abstract: We herein report the case of a 37-year-old type 1 diabetic pregnant woman treated with an insulin pump. Although the patient's glycemic control deteriorated following progesterone treatment for the prevention of preterm delivery and miscarriage, it was improved by adjusting the basal insulin rate on the days of progesterone treatment. Excess progesterone is known to impair both insulin sensitivity and secretion. The present case is the first report to evaluate deterioration of glycemic control induced by progesterone treatment and to determine the dose of insulin required in a type 1 diabetic pregnant woman whose insulin secretion was completely depleted.
authors: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan.
authors: Shugo
authors: S
authors: Sasaki
authors: Tetsuyuki
authors: T
authors: Yasuda
authors: Hideaki
authors: H
authors: Kaneto
authors: Akio
authors: A
authors: Kuroda
authors: Yukari
authors: Y
authors: Fujita
authors: Keiko
authors: K
authors: Fujisawa
authors: Yukiko
authors: Y
authors: Tabuchi
authors: Ryuichi
authors: R
authors: Kasami
authors: Taka-Aki
authors: TA
authors: Matsuoka
authors: Munehide
authors: M
authors: Matsuhisa
authors: Iichiro
authors: I
authors: Shimomura
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D007332:Insulin Infusion Systems; D010865:Pilot Projects; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood / Q000188:drug therapy*; D011374:Progesterone / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007328:Insulin; D011374:Progesterone