title: Medullary breast carcinoma in an 18-year-old female: report on one case diagnosed on fine-needle cytology sample.
abstract: Medullary breast carcinoma (MBC) is a rare epithelial malignancy of the breast accounting for about 1-7% of all breast carcinomas. It is characterized by well-defined borders, a syncytial/solid pattern of growth of high grade atypical cells showing no glandular differentiation and a massive diffuse lympho-plasmacytic peritumoral infiltrate. Despite the high-grade atypias characterizing this neoplasm, MBC has been reported to have a better prognosis when compared with the common infiltrating duct carcinoma. MBCs typically lack estrogen and progesterone receptor (ER and PgR) expression and have a low incidence of ERBB2 overexpression. Genetically, they are often associated with BRCA-1 oncogene mutations and TP53 alterations. While MBC generally occurs in middle-aged women, ranging from 45 to 52 years of age, we report the case of a 18-year-old female patient which was diagnosed by means of fine-needle cytology sample.
authors: Serviço de Anatomia Patologica, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
authors: Antonio
authors: A
authors: Galzerano
authors: Nicola
authors: N
authors: Rocco
authors: Antonello
authors: A
authors: Accurso
authors: Giuseppe
authors: G
authors: Ciancia
authors: Anna Cipolletta
authors: AC
authors: Campanile
authors: Ferdinando
authors: F
authors: Caccavello
authors: Franco
authors: F
authors: Fulciniti
mesh_terms: D000293:Adolescent; D019313:BRCA1 Protein / Q000235:genetics*; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D018276:Carcinoma, Medullary / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D009154:Mutation; D060787:Neoplasm Grading
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human
keywords: breast neoplasms; fine-needle cytology; juvenile breast carcinoma; medullary breast carcinoma