title: [Clinical analysis of 52 cases of adenoid cystic carcinoma in minor salivary gland].
abstract: OBJECTIVE
  To investigate the prognosis of adenoid cystic carcinoma (ACC) in minor salivary glands and its influencing factors.
  
  
  METHODS
  Clinical data of 52 patients with ACC in minor salivary glands were reviewed. The distribution of stage was as follows: stage I (6%), stage II (21%), stage III (27%) and stage IV (46%). Counting data was analyzed by χ(2) test or Fisher's exact. Survival rates were calculated by Kaplan-Merier method. Statistical significance of differences in the cumulative survival curves was evaluated using the Log-rank test. Multivariate analysis was performed by Cox proportional hazard model.
  
  
  RESULTS
  All patients underwent primary tumor radical resection, 39 patients (75%) received postoperative radiation. The regional recurrence rate was 37% and distant metastasis rate was 21%. The 5-, 10-year cumulative local control rate were 68% and 63% respectively. The 5-, 10-year cumulative distant control rate were 86%, 68% respectively. The 5-, 10-year tumor specific survival rates were 70% and 54% respectively. Multivariate analysis showed that T stage, lymph node metastasis and perineural invasion were relevant to the tumor specific survival of ACC in minor salivary glands.
  
  
  CONCLUSIONS
  Recurrence and metastasis were the main cause of treatment failure of ACC in minor salivary glands. T stage, lymph node metastasis and perineural invasion were the independent prognostic factors of ACC in minor salivary glands. Radical surgery and reasonably postoperative radiotherapy were the main treatment strategy.
authors: Department of Head and Neck Surgery, Zhejiang Tumor Hospitol, Hangzhou 310022, China.
authors: Jia-feng
authors: JF
authors: Wang
authors: Ming-hua
authors: MH
authors: Ge
authors: Ke-jing
authors: KJ
authors: Wang
authors: Zhuo
authors: Z
authors: Tan
authors: Chao
authors: C
authors: Chen
authors: Jia-jie
authors: JJ
authors: Xu
mesh_terms: D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010315:Particle Accelerators; D016016:Proportional Hazards Models; D018714:Radiotherapy, Adjuvant; D012468:Salivary Gland Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D012470:Salivary Glands, Minor; D015996:Survival Rate; D055815:Young Adult
chemical_list: D003037:Cobalt Radioisotopes