title: Epidemiology of extra-pulmonary tuberculosis in Israel, 1999-2010.
abstract: METHODS
  The Israeli national tuberculosis (TB) surveillance system.
  
  
  OBJECTIVE
  To describe the epidemiology of extra-pulmonary tuberculosis (EPTB) in Israel between 1999 and 2010 and identify more susceptible populations.
  
  
  METHODS
  Data were retrieved from the National Tuberculosis Registry and the Israeli Bureau of Statistics.
  
  
  RESULTS
  During the study period, 995 EPTB patients were notified, corresponding to 19.6% of all TB cases. The average annual male:female ratio was 0.8, and the human immunodeficiency virus (HIV) infection rate was 5%. Most EPTB affected the lymph nodes (39.8%), pleura (16.9%) and urinary system (11.1%). Most EPTB patients (81.8%) were non-Israeli born. The estimated average annual incidence in Israeli-born citizens, non-Israeli-born citizens and migrant workers was respectively 0.23, 2.2 and 7.5 per 100,000 population. The ratio of non-Israeli-born migrant workers to non-Israeli-born citizens with EPTB decreased from 1:6.3 in 1999 to 1:0.78 in 2010. Culture results were obtained for 624 (62.9%) of all cases. Of these, 41 (6.6%) were resistant to at least one first-line anti-tuberculosis drug and 8 (1.3%) were multidrug-resistant. Treatment success was achieved in 86.5%.
  
  
  CONCLUSIONS
  Physicians should be aware of the possibility of EPTB in older patients, especially in the non-Israeli-born. Innovative screening procedures should be implemented for migrants from high-burden countries.
authors: Department of Tuberculosis and AIDS, Ministry of Health, Jerusalem, Israel. zohar.mor@rml.health.gov.il
authors: Z
authors: Z
authors: Mor
authors: G
authors: G
authors: Pinsker
authors: N
authors: N
authors: Cedar
authors: M
authors: M
authors: Lidji
authors: I
authors: I
authors: Grotto
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D012042:Registries; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology*; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D000995:Antitubercular Agents