title: Quantitative evaluation of ventricular dilatation using computed tomography in infants with congenital cytomegalovirus infection.
abstract: BACKGROUND
  Infants with congenital cytomegalovirus infection (CCMVI) may develop brain abnormalities such as ventricular dilatation, which may potentially associate with sensorineural hearing loss. There is currently no recognized method for quantitative evaluation of ventricle size in infants with CCMVI. Our objectives were to establish a method for quantitative evaluation of ventricle size using computed tomography (CT) in infants with CCMVI, and determine a cut-off value associated with abnormal auditory brainstem response (ABR) early in life.
  
  
  METHODS
  This study enrolled 19 infants with CCMVI and 21 non-infected newborn infants as a control group. Infants with CCMVI were divided into two subgroups according to ABR at the time of initial examination: normal ABR (11 infants) or abnormal ABR (8 infants). Ventricle size was assessed by calculating Evans' index (EI) and lateral ventricle width/hemispheric width (LVW/HW) ratio on brain CT images, and was compared among groups. A cut-off ventricle size associated with abnormal ABR was determined.
  
  
  RESULTS
  EI and LVW/HW ratio were significantly higher in the CCMVI with abnormal ABR group than the control and CCMVI with normal ABR groups. Cut-off values of 0.26 for EI and 0.28 for LVW/HW ratio had a sensitivity of 100% and 100%, respectively, and a specificity of 73% and 91%, respectively, for association with abnormal ABR.
  
  
  CONCLUSIONS
  We established a method for quantitative evaluation of ventricle size using EI and LVW/HW ratio on brain CT images in infants with CCMVI. LVW/HW ratio had a more association with abnormal ABR in the early postnatal period than EI.
authors: Department of Pediatrics, Kobe University Hospital, Kobe, Japan.
authors: Kiyomi
authors: K
authors: Matsuo
authors: Department of Pediatrics, Kobe University Hospital, Kobe, Japan. Electronic address: ichim@med.kobe-u.ac.jp.
authors: Ichiro
authors: I
authors: Morioka
authors: Department of Radiology, Kobe University Hospital, Kobe, Japan.
authors: Mai
authors: M
authors: Oda
authors: Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan.
authors: Yoko
authors: Y
authors: Kobayashi
authors: Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan.
authors: Yuji
authors: Y
authors: Nakamachi
authors: Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan.
authors: Seiji
authors: S
authors: Kawano
authors: Department of Pediatrics, Kobe University Hospital, Kobe, Japan.
authors: Miwako
authors: M
authors: Nagasaka
authors: Department of Pediatrics, Kobe University Hospital, Kobe, Japan.
authors: Tsubasa
authors: T
authors: Koda
authors: Department of Pediatrics, Kobe University Hospital, Kobe, Japan.
authors: Tomoyuki
authors: T
authors: Yokota
authors: Department of Pediatrics, Kobe University Hospital, Kobe, Japan.
authors: Satoru
authors: S
authors: Morikawa
authors: Department of Pediatrics, Kobe University Hospital, Kobe, Japan.
authors: Akihiro
authors: A
authors: Miwa
authors: Department of Pediatrics, Kobe University Hospital, Kobe, Japan.
authors: Akio
authors: A
authors: Shibata
authors: Research Center for Disease Control, Aisenkai Nichinan Hospital, Nichinan, Japan.
authors: Toshio
authors: T
authors: Minematsu
authors: Department of Virology I, National Institute of Infectious Disease, Tokyo, Japan.
authors: Naoki
authors: N
authors: Inoue
authors: Department of Obstetrics and Gynecology, Kobe University Hospital, Kobe, Japan.
authors: Hideto
authors: H
authors: Yamada
authors: Department of Pediatrics, Kobe University Hospital, Kobe, Japan.
authors: Kazumoto
authors: K
authors: Iijima
mesh_terms: D002552:Cerebral Ventricles / Q000002:abnormalities* / Q000473:pathology*; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012372:ROC Curve; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
keywords: Auditory brainstem response; Cytomegalovirus infection; Evans’ index; Lateral ventricle width/hemispheric width ratio; Ventricle