title: Antimigratory Effects of the Methanol Extract from Momordica charantia on Human Lung Adenocarcinoma CL1 Cells.
abstract: Momordica charantia has been found to exhibit anticancer activity, in addition to its well-known therapeutic functions. We have demonstrated that the leaf extract of Momordica charantia (MCME) induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways. In this study, a different susceptibility to MCME was found in human lung adenocarcinoma CL1 cells with different metastatic ability, leading to the significant difference of cell viability and invasiveness between MCME-treated CL1-0 and CL1-5 cells. MCME was found to upregulate the expression of Wnt-2 and affect the migratory and invasive ability of CL1 cells through suppressed MMP-2 and MMP-9 enzymatic activities. We proposed that MCME mediates inhibition against migration of CL1 cells by reducing the expression and activation of Src and FAK to decrease the expression of downstream Akt, β-catenin, and MMPs.
authors: Department of Life Sciences, Tzu-Chi University, Hualien, Taiwan ; Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan.
authors: Hsue-Yin
authors: HY
authors: Hsu
authors: Jung-Hsuan
authors: JH
authors: Lin
authors: Chia-Jung
authors: CJ
authors: Li
authors: Shih-Fang
authors: SF
authors: Tsang
authors: Chun-Hao
authors: CH
authors: Tsai
authors: Jong-Ho
authors: JH
authors: Chyuan
authors: Shu-Jun
authors: SJ
authors: Chiu
authors: Shuang-En
authors: SE
authors: Chuang