title: First night effect analysis in a cohort of young children with autism spectrum disorder.
abstract: OBJECTIVE
  To evaluate for the first night effect (FNE) in a group of young children with autism.
  
  
  METHODS
  Analysis of polysomnographic data from a 2-night sleep laboratory study.
  
  
  METHODS
  Clinical Center of the National Institutes of Health.
  
  
  METHODS
  15 children (aged 2-10 years) with a diagnosis of an ASD.
  
  
  METHODS
  None.
  
  
  RESULTS
  Polysomnographic analysis showed the presence of a FNE for wake after sleep onset minutes, stage 2, and sleep efficiency, but not for REM sleep parameters or TST.
  
  
  CONCLUSIONS
  In this 2-night polysomnographic analysis of sleep stages in young children with autism, we did not find the expected second night increase in total sleep time or REM sleep percentage or a decrease in REM sleep latency. This lack of an FNE for TST and REM parameters suggests that a single-night polysomnogram may be sufficient to evaluate children with an ASD for TST or REM parameters.
authors: National Institute of Mental Health, Pediatrics and Developmental Neuroscience Branch, Bethesda, MD 20982, USA. Shu.buckley@nih.gov
authors: Ashura
authors: A
authors: Buckley
authors: Katherine
authors: K
authors: Wingert
authors: Susan
authors: S
authors: Swedo
authors: Audrey
authors: A
authors: Thurm
authors: Susumu
authors: S
authors: Sato
authors: Shmuel
authors: S
authors: Appel
authors: Alcibiades J
authors: AJ
authors: Rodriguez
mesh_terms: D002648:Child; D002659:Child Development Disorders, Pervasive / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography / Q000379:methods / Q000523:psychology; D012890:Sleep / Q000502:physiology; D012894:Sleep Stages / Q000502:physiology; D012893:Sleep Wake Disorders / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D013997:Time Factors