title: Structural changes in dendritic loci and protective effect of neurotrophic factors from the cerebral cortex of animals with favorable outcome of experimental hemorrhagic stroke.
abstract: Structural changes in the sensorimotor cortex of the cerebral hemispheres were studied in rats with experimental hemorrhagic stroke in the internal capsule. Changes in the shape and decrease in the density distribution of spines on apical dendrites of layer V pyramidal neurons of the sensorimotor cortex were revealed. Some fractions isolated from the complex of neurotrophic factors of the cerebral cortex of animals with a favorable outcome of hemorrhagic stroke were shown to affect the distal and proximal dendritic loci. As differentiated from the "nonactive" fraction, the "active" fraction improved the behavior of rats surviving hemorrhagic stroke. The density distribution of spines (particularly in the distal region of apical dendrites of pyramidal neurons in layer V of the cerebral cortex) was stabilized after treatment with the "active" fraction. The "nonactive" fraction had a selective effect on the proximal loci.
authors: Laboratory of Functional Neurocytology, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.
authors: E V
authors: EV
authors: Goloborodko
authors: D A
authors: DA
authors: Volkova
authors: N S
authors: NS
authors: Kositzyn
authors: M M
authors: MM
authors: Svinov
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology*; D003712:Dendrites / Q000378:metabolism / Q000473:pathology*; D020300:Intracranial Hemorrhages / Q000473:pathology*; D008297:Male; D009044:Motor Cortex / Q000502:physiology; D009414:Nerve Growth Factors / Q000378:metabolism / Q000494:pharmacology*; D009474:Neurons / Q000648:ultrastructure*; D017966:Pyramidal Cells / Q000502:physiology / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D020521:Stroke / Q000473:pathology*
chemical_list: D009414:Nerve Growth Factors