title: Controlled drug release system based on cyclodextrin-conjugated poly(lactic acid)-b-poly(ethylene glycol) micelles.
abstract: Cyclodextrin-conjugated poly(lactic acid)-b-poly(ethylene glycol) (β-CD-PLA-mPEG), a well-defined amphiphilic copolymer, was synthesized by controlled ring-open copolymerization and click coupling reaction, in order to obtain a biocompatible drug delivery system with controlled release profiles. The β-CD-PLA-mPEG copolymer could self-assemble in aqueous solution to form micelles with a mean particle size of 173.4 nm, which will decrease to 159.2 nm after loaded with a kind of hydrophobic drug (indomethacin, IND). The IND-loaded β-CD-PLA-mPEG micelles show spherical shape within the nano-size scale under TEM imaging. Compared with that formed by PLA-mPEG, the micelles formed by β-CD-PLA-mPEG copolymer present higher drug loading efficiency and controlled release profile of IND, especially in the control of its initial burst release. Meanwhile, β-CD-PLA-mPEG copolymer exhibits low toxicity to cells. The micelles formed by β-CD-PLA-mPEG copolymer could be a promising controlled release system for various hydrophobic drugs.
authors: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors: Qin
authors: Q
authors: He
authors: Wei
authors: W
authors: Wu
authors: Kemao
authors: K
authors: Xiu
authors: Qian
authors: Q
authors: Zhang
authors: Fujian
authors: F
authors: Xu
authors: Jianshu
authors: J
authors: Li
mesh_terms: D000818:Animals; D019556:COS Cells; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D002850:Chromatography, Gel; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D007213:Indomethacin / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D007773:Lactates / Q000138:chemical synthesis / Q000737:chemistry*; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007773:Lactates; D008823:Micelles; D047392:beta-Cyclodextrins; C088513:poly(lactic acid-ethylene glycol); D011092:Polyethylene Glycols; D007213:Indomethacin