title: Growth after hematopoietic stem cell transplantation in children with acute myeloid leukemia.
abstract: Previous studies have shown that hematopoietic stem cell transplantation (HSCT) may result in growth impairment. The purpose of this study was to evaluate the growth during 5 yr after HSCT and to determine factors that influence final adult height (FAH). We retrospectively reviewed the medical records of acute myeloid leukemia (AML) patients who received HSCT. Among a total of 37 eligible patients, we selected 24 patients who began puberty at 5 yr after HSCT (Group 1) and 19 patients who reached FAH without relapse (Group 2). In Group 1, with younger age at HSCT, sex, steroid treatment, hypogonadism and hypothyroidism were not significantly associated with growth impairment 5 yr after HSCT. History of radiotherapy (RT) significantly impaired the 5 yr growth after HSCT. Chronic graft-versus-host disease (cGVHD) only temporarily impaired growth after HSCT. In Group 2, with younger age at HSCT, steroid treatment and hypogonadism did not significantly reduce FAH. History of RT significantly reduced FAH. Growth impairment after HSCT may occur in AML patients, but in patients without a history of RT, growth impairment seemed to be temporary and was mitigated by catch-up growth.
authors: Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.
authors: Seung Joon
authors: SJ
authors: Chung
authors: Seung Wan
authors: SW
authors: Park
authors: Min Kyoung
authors: MK
authors: Kim
authors: Min Jae
authors: MJ
authors: Kang
authors: Young Ah
authors: YA
authors: Lee
authors: Seong Yong
authors: SY
authors: Lee
authors: Choong Ho
authors: CH
authors: Shin
authors: Sei Won
authors: SW
authors: Yang
authors: Hyoung Jin
authors: HJ
authors: Kang
authors: Kyung Duk
authors: KD
authors: Park
authors: Hee Young
authors: HY
authors: Shin
authors: Hyo Seop
authors: HS
authors: Ahn
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000528:radiation effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy / Q000473:pathology; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013256:Steroids / Q000627:therapeutic use
chemical_list: D013256:Steroids
keywords: Acute Myeloid Leukemia; Growth; Hematopoietic Stem Cell Transplantation; Radiotherapy; Total Body Irradiation