title: Three-component domino reactions for regioselective formation of bis-indole derivatives.
abstract: A microwave-assisted regioselective reaction dealing with arylglyoxal monohydrate, diverse N-aryl enaminones, and indoles to achieve 3,2'- and 3,3'-bis-indoles by varying a substituted indole substrate is reported. The 2-unsubstituted indoles resulted in the 3,2'-bis-indole skeleton, whereas indoles bearing a methyl or phenyl group at C2 led to the 3,3'-bis-indoles with simultaneous formation of three sigma-bonds. The procedures feature excellent regioselectivity, short reaction times, convenient one-pot manner, and operational simplicity.
authors: School of Chemistry and Chemical Engineering, Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P.R. China.
authors: Li-Ping
authors: LP
authors: Fu
authors: Qing-Qing
authors: QQ
authors: Shi
authors: Yu
authors: Y
authors: Shi
authors: Bo
authors: B
authors: Jiang
authors: Shu-Jiang
authors: SJ
authors: Tu
mesh_terms: D000588:Amines / Q000737:chemistry; D018360:Crystallography, X-Ray; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008872:Microwaves; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007211:Indoles