title: [Correlation between plasma concentrations of homocysteine and diabetic polyneuropathy evaluated with the Semmes-Weinstein monofilament test in patients with type 2 diabetes mellitus].
abstract: OBJECTIVE
  Few modifiable risk factors are known to be associated with the presence and progression of diabetic polyneuropathy (DPN).
  
  
  METHODS
  We have analyzed in 405 type 2 diabetic (T2DM) subjects (169 women) the association of plasma homocysteine with the presence of DPN measured with the Semmes-Weinstein (SW) monofilament test. A score below 4 was considered an altered SW monofilament test. Plasma homocysteine, vitamin B12 and folic acid were measured using standard procedures (ELISA).
  
  
  RESULTS
  Patients with T2DM with altered SW test have significantly higher age, evolution of disease, HbA1c and lower creatinine clearance values. In addition, plasma homocysteine values were independently and significantly higher in T2DM with DPN measured as altered SW test (13.64 ± 4.93 vs. 12.22 ± 4.48 μmol/l, P<.01) with similar vitamin B12 and folic acid values comparing the 2 groups.
  
  
  CONCLUSIONS
  Plasma homocysteine and HbA1c values are the 2 modifiable biological factors associated with the presence of DPN evaluated as an altered SW monofilament test in T2DM subjects.
authors: Servicio de Endocrinología, Hospital Clínico Universitario, Valencia, España.
authors: Mercedes
authors: M
authors: Molina
authors: Ricardo
authors: R
authors: Gonzalez
authors: José
authors: J
authors: Folgado
authors: José T
authors: JT
authors: Real
authors: Sergio
authors: S
authors: Martínez-Hervás
authors: Antonia
authors: A
authors: Priego
authors: Rosario
authors: R
authors: Lorente
authors: F Javier
authors: FJ
authors: Chaves
authors: Juan F
authors: JF
authors: Ascaso
mesh_terms: D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D003929:Diabetic Neuropathies / Q000097:blood* / Q000175:diagnosis; D018450:Disease Progression; D005260:Female; D005492:Folic Acid / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications*; D006987:Hypesthesia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000453:epidemiology; D010808:Physical Examination; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000453:epidemiology; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D003404:Creatinine; D005492:Folic Acid; D006442:Glycated Hemoglobin; D006710:Homocysteine; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D014805:Vitamin B 12
keywords: Diabetic polineuropathy; Homocisteína; Homocysteine; Monofilament; Monofilamento; Polineuropatía diabética