title: Blood microRNAs in low or no risk ischemic stroke patients.
abstract: Ischemic stroke is a multi-factorial disease where some patients present themselves with little or no risk factors. Blood microRNA expression profiles are becoming useful in the diagnosis and prognosis of human diseases. We therefore investigated the blood microRNA profiles in young stroke patients who presented with minimal or absence of risk factors for stroke such as type 2 diabetes, dyslipidemia and hypertension. Blood microRNA profiles from these patients varied with stroke subtypes as well as different functional outcomes (based on modified Rankin Score). These microRNAs have been shown to target genes that are involved in stroke pathogenesis. The findings from our study suggest that molecular mechanisms in stroke pathogenesis involving low or no risk ischemic stroke patients could differ substantially from those with pre-existing risk factors.
authors: Department of Biochemistry and Neuroscience Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597, Singapore. bchjeya@nus.edu.sg.
authors: Jun Rong
authors: JR
authors: Tan
authors: Kay Sin
authors: KS
authors: Tan
authors: Yu Xuan
authors: YX
authors: Koo
authors: Fung Lin
authors: FL
authors: Yong
authors: Chee Woon
authors: CW
authors: Wang
authors: Arunmozhiarasi
authors: A
authors: Armugam
authors: Kandiah
authors: K
authors: Jeyaseelan
mesh_terms: D000293:Adolescent; D000328:Adult; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000175:diagnosis*
chemical_list: D035683:MicroRNAs