title: [Safety and short-term efficacy of renal sympathetic denervation in the treatment of resistant hypertension].
abstract: OBJECTIVE
  Transcatheter renal sympathetic denervation (RDN) is a novel technology/therapy in treating resistant hypertension. The present study aims to evaluate the safety and short-term efficacy of RDN for the treatment of resistant hypertension in a Chinese population.
  
  
  METHODS
  This prospective single-center pilot study was the first one conducted in China with Medtronic Ardian Symplicity Catheter System. Eight patients (6 males and 2 females) with resistant hypertension underwent RDN at our hospital from February to April 2012. All patients were followed up at one month and three months post-RDN. Blood pressure, use of antihypertensive medications, renal function and complications were recorded and analyzed.
  
  
  RESULTS
  At one month and three months post-RDN, 24-hour ambulatory blood pressure monitoring showed mean systolic blood pressure and diastolic blood pressure decreased 10 (0 - 18) 13 (3 - 19) and 8 (-2 - 15), 9 (2 - 16) mm Hg throughout 24 hours respectively (P < 0.05, vs baseline). The number of drugs decreased from 4.3 ± 0.5 to 2.8 ± 0.9 and 2.5 ± 0.7 post-RSD respectively (P < 0.01). There was no significant change of renal function (P > 0.05). No complications were observed.
  
  
  CONCLUSIONS
  The preliminary results revealed that RDN was safe and effective for the treatment of resistant hypertension in the Chinese population during a 3-month follow-up. Further large and long-term studies are warranted.
authors: Department of Cardiology, Fuwai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100037, China.
authors: Xiong-jing
authors: XJ
authors: Jiang
authors: Tuo
authors: T
authors: Liang
authors: Hui
authors: H
authors: Dong
authors: Meng
authors: M
authors: Peng
authors: Wen-jun
authors: WJ
authors: Ma
authors: Ting
authors: T
authors: Guan
authors: Hui-min
authors: HM
authors: Zhang
authors: Jin
authors: J
authors: Bian
authors: Bo
authors: B
authors: Xu
authors: Run-lin
authors: RL
authors: Gao
mesh_terms: D000328:Adult; D017115:Catheter Ablation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000601:surgery*; D007668:Kidney / Q000294:innervation; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D013562:Sympathectomy / Q000379:methods*; D016896:Treatment Outcome