title: Review and recommendations for the prevention, management, and treatment of postoperative and postdischarge nausea and vomiting.
abstract: Patients have rated severe nausea to be worse than postoperative pain. The overall incidence of postoperative nausea and vomiting (PONV) is 25%-30% and can lead to delayed discharge and unanticipated hospital admission. After outpatient surgery, the overall incidence of postdischarge nausea has been reported to be 17% and of vomiting 8%, higher than nausea and vomiting reported during the procedure or recovery. Patients who experienced postdischarge nausea and vomiting (PDNV) were unable to resume normal daily activities as quickly. This paper addresses the frequency, pathophysiology and patient perception of PONV and PDNV and reviews antiemetics and adjunctive medications used for the prevention, management, and treatment of PONV and PDNV. For each, the indication, mechanism of action, adverse effects, drug interactions, and implications for oral surgery and outpatient sedation are provided. Because many antiemetics are available for prevention, management, and treatment of PONV and PDNV, optimal medication choices are important for each procedure and patient.
authors: Department of Pharmaceutical, Social, and Administrative Sciences, McWhorter School of Pharmacy, Samford University, Birmingham, Alabama 35229, USA.
authors: Danielle
authors: D
authors: Cruthirds
authors: Pamela J
authors: PJ
authors: Sims
authors: Patrick J
authors: PJ
authors: Louis
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects; D000932:Antiemetics / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000145:classification / Q000627:therapeutic use; D016292:Procedural Sedation / Q000009:adverse effects; D006801:Humans; D018377:Neurotransmitter Agents / Q000145:classification / Q000627:therapeutic use; D019647:Oral Surgical Procedures; D010351:Patient Discharge; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy / Q000517:prevention & control*; D012307:Risk Factors
chemical_list: D000932:Antiemetics; D014150:Antipsychotic Agents; D018377:Neurotransmitter Agents