title: Thr21Met (T21M) but not Ser89Asn (S89N) polymorphisms of the urotensin-II (UTS-II) gene are associated with Behcet's disease (BD).
abstract: Behcet's disease (BD) is multisytemic vasculitis or chronic inflammation that may lead to various autoimmune and autoinflammatory syndromes. Exact etiopathogenesis of BD has not been clarified yet. Urotensin II (UTS-II) is predominantly a vasoactive peptide and Thr21Met polymorphism in UTS-II gene was proved to increasing in some autoimmune diseases. Considering these, our objective was to evaluate whether two UTS-II gene polymorphisms (Thr21Met and Ser89Asn) were responsible in genetic susceptibility to BD in a Turkish population. A total of 198 patients with BD and 275 healthy controls were enrolled. We analyzed the genotype and allele frequencies of two UTS-II gene polymorphisms, Thr21Met and Ser89Asn, in BD patients and in controls. We found that Thr21Met but not Ser89Asn polymorphisms of the UTS-II gene were markedly associated with the risk of developing BD (p<0.0001), The Met21Met genotype was less common among BD patients (6.1% in patients vs. 17.1% in controls; p<0.0001). There was also an increase in the 21Thr allele (54.8% in BD patients vs. 43.8% in controls) and a decrease in 21Met allele frequencies (45.2% in controls vs. 56.2% in patients) in the BD groups (p<0.0044). To the best of our knowledge, for the first time in the literature, our study claims that there is an association between Thr21Met, and not between Ser89Asn polymorphisms in the UTS-II gene and BD. These results put a new player to the field of undiscovered pathogenesis of BD and hopefully provide new insights to the treatment options.
authors: Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. serdaroztuzcu@gmail.com
authors: Serdar
authors: S
authors: Oztuzcu
authors: Mustafa
authors: M
authors: Ulasli
authors: Yavuz
authors: Y
authors: Pehlivan
authors: Muhammer Özgür
authors: MÖ
authors: Cevik
authors: Beyhan
authors: B
authors: Cengiz
authors: Bulent
authors: B
authors: Gogebakan
authors: Yusuf Ziya
authors: YZ
authors: Igci
authors: Seydi
authors: S
authors: Okumuş
authors: Ahmet
authors: A
authors: Arslan
authors: Ahmet Mesut
authors: AM
authors: Onat
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014421:Turkey; D014579:Urotensins / Q000235:genetics*
chemical_list: D014579:Urotensins; C029677:urotensin II