title: Ovariectomy causes overexpression of renal Na(+),K(+)-ATPase and sodium-sensitive hypertension in adult Wistar rats.
abstract: We investigated the effect of ovariectomy(oVx) on renal and systemic hemodynamic, electrolyte excretion and total and dephosphorylated Na(+),K(+)-ATPase α1 subunit (t-d-NKA) in normotensive Wistar rats under a normal sodium (NS, 0.24%) or high sodium (HS, 1%) intake versus intact female (IF). On NS intake, t-d-NKA was higher in oVx rats and overexpressed in the thick ascending limbs (P < .01 vs. IF) and renal plasma flow was increased. On HS intake, oVx rats maintained a greater dephosphorylated NKA, excreted less sodium, and developed arterial hypertension (134 ± 4 vs. IF 112 ± 5 mm Hg, P < .05). Sodium load caused salt-sensitive hypertension in oVx Wistar rats.
authors: Laboratorio de Riñón, Instituto de Investigaciones Médicas A Lanari, Buenos Aires University , Buenos Aires , Argentina.
authors: Luis A
authors: LA
authors: Di Ciano
authors: Pablo J
authors: PJ
authors: Azurmendi
authors: Jorge E
authors: JE
authors: Toledo
authors: Elisabet M
authors: EM
authors: Oddo
authors: Elsa
authors: E
authors: Zotta
authors: Federico
authors: F
authors: Ochoa
authors: Elvira E
authors: EE
authors: Arrizurieta
authors: Fernando R
authors: FR
authors: Ibarra
mesh_terms: D000818:Animals; D001794:Blood Pressure; D005260:Female; D006973:Hypertension / Q000201:enzymology* / Q000209:etiology* / Q000503:physiopathology; D007668:Kidney / Q000201:enzymology*; D008138:Loop of Henle / Q000201:enzymology; D009318:Natriuresis; D010052:Ovariectomy / Q000009:adverse effects*; D010053:Ovary / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D017595:Renal Plasma Flow; D012982:Sodium, Dietary / Q000008:administration & dosage; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D012982:Sodium, Dietary; C499075:Atp1a1 protein, rat; D000254:Sodium-Potassium-Exchanging ATPase