title: Towards a gene expression biomarker set for human biological age.
abstract: We have previously described a statistical model capable of distinguishing young (age <65 years) from old (age ≥75 years) individuals. Here we studied the performance of a modified model in three populations and determined whether individuals predicted to be biologically younger than their chronological age had biochemical and functional measures consistent with a younger biological age. Those with 'younger' gene expression patterns demonstrated higher muscle strength and serum albumin, and lower interleukin-6 and blood urea concentrations relative to 'biologically older' individuals (odds ratios 2.09, 1.64, 0.74, 0.74; P = 2.4 × 10(-2) , 3.5 × 10(-4) , 1.8 × 10(-2) , 1.5 × 10(-2) , respectively). We conclude that our expression signature of age is robust across three populations and may have utility for estimation of biological age.
authors: Institute of Biomedical and Clinical Science, Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
authors: Alice C
authors: AC
authors: Holly
authors: David
authors: D
authors: Melzer
authors: Luke C
authors: LC
authors: Pilling
authors: William
authors: W
authors: Henley
authors: Dena G
authors: DG
authors: Hernandez
authors: Andrew B
authors: AB
authors: Singleton
authors: Stefania
authors: S
authors: Bandinelli
authors: Jack M
authors: JM
authors: Guralnik
authors: Luigi
authors: L
authors: Ferrucci
authors: Lorna W
authors: LW
authors: Harries
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D015870:Gene Expression; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008875:Middle Aged; D053580:Muscle Strength / Q000235:genetics*; D012709:Serum Albumin / Q000378:metabolism*; D014508:Urea / Q000097:blood*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D012709:Serum Albumin; D014508:Urea