title: Plasma and synovial fluid programmed cell death 5 (PDCD5) levels are inversely associated with TNF-α and disease activity in patients with rheumatoid arthritis.
abstract: BACKGROUND
  Programmed cell death 5 (PDCD5), a novel apoptotic regulatory gene, has been reported to be associated with rheumatoid arthritis (RA) and osteoarthritis (OA), which can regulate the apoptosis of synoviocytes and chondrocytes cultured in vitro.
  
  
  OBJECTIVE
  To study expression characteristic of PDCD5 in plasma and synovial fluid of RA patients, and analyze its correlation with tumor necrosis factor alpha (TNF-α) and disease activity in RA.
  
  
  METHODS
  A total of 135 subjects were recruited into this study (44 RA patients, 46 OA patients and 45 healthy controls). PDCD5 and TNF-α concentrations in plasma and synovial fluid were analyzed by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Plasma and synovial fluid PDCD5 concentrations were significantly elevated in RA patients. Pearson correlation analysis indicated that plasma and synovial fluid PDCD5 levels were inversely correlated with TNF-α. Moreover, plasma PDCD5 levels were also inversely correlated with C-reactive protein and erythrocyte sedimentation rate.
  
  
  CONCLUSIONS
  Plasma and synovial fluid PDCD5 could be useful for monitoring the activity and progression of RA, and its abnormal expression and dysfunction may be correlated to TNF-α in RA patients.
authors: Arthritis Clinic and Research Center, Peking University People's Hospital, Beijing, P R China.
authors: Junfeng
authors: J
authors: Wang
authors: Zhenpeng
authors: Z
authors: Guan
authors: Zigang
authors: Z
authors: Ge
mesh_terms: D000328:Adult; D051017:Apoptosis Regulatory Proteins / Q000097:blood* / Q000235:genetics; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D015415:Biomarkers / Q000097:blood / Q000737:chemistry; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood* / Q000235:genetics; D010003:Osteoarthritis / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D013582:Synovial Fluid / Q000737:chemistry / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood* / Q000235:genetics
chemical_list: D051017:Apoptosis Regulatory Proteins; D015415:Biomarkers; D009363:Neoplasm Proteins; C117283:PDCD5 protein, human; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein