title: Lack of Clostridium difficile infection in patients treated with rifaximin for hepatic encephalopathy: a retrospective analysis.
abstract: OBJECTIVE
  The purpose of this study was to assess the incidence of Clostridium difficile infection in patients who received rifaximin for the treatment of hepatic encephalopathy (HE).
  
  
  METHODS
  Medical charts of patients who received rifaximin for the treatment of HE were reviewed. The number of patients who developed diarrhea during treatment with rifaximin and results of latex agglutination assays to detect C. difficile in stool samples were analyzed.
  
  
  RESULTS
  A total of 211 patients received rifaximin for HE. Of these, 152 were treated in a university practice and 59 were treated in community practices. The mean dose of rifaximin was 1055 mg/d (range, 600 to 1600 mg/d) for a mean duration of 250 days (range, 180 to 385 d). Eighteen patients developed diarrhea during rifaximin treatment. None of these patients tested positive for C. difficile.
  
  
  CONCLUSIONS
  This study demonstrates that treatment of HE with the safe, nonsystemic, gut-selective antibiotic rifaximin was not associated with the development of C. difficile infection.
authors: Tampa General Medical Group, Tampa, FL 33606, USA. gneff@tgh.org
authors: Guy W
authors: GW
authors: Neff
authors: Michael
authors: M
authors: Jones
authors: Mark
authors: M
authors: Jonas
authors: Ravi
authors: R
authors: Ravinuthala
authors: David
authors: D
authors: Novick
authors: Tiffany E
authors: TE
authors: Kaiser
authors: Nyingi
authors: N
authors: Kemmer
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016360:Clostridioides difficile / Q000472:pathogenicity*; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology; D004761:Enterocolitis, Pseudomembranous / Q000453:epidemiology* / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D005260:Female; D006501:Hepatic Encephalopathy / Q000188:drug therapy*; D006801:Humans; D015994:Incidence; D007841:Latex Fixation Tests; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012294:Rifamycins / Q000009:adverse effects / Q000627:therapeutic use*; D000078262:Rifaximin; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D000890:Anti-Infective Agents; D012294:Rifamycins; D000078262:Rifaximin