title: TGF-beta1 on osteoimmunology and the bone component cells.
abstract: TGF-β1 is an immunoregulatory cytokine that regulates immune cell proliferation, survival, differentiation, and migration. Compelling evidence has demonstrated a strong association between the immune and skeletal systems (so called Osteoimmunology), such as the critical role of TGF-β1 in the development and maintenance of the skeletal tissue. This review provides an overview of the mechanisms in which TGF-β1 interacts with bone component cells, such as osteoblasts, osteoclasts, chondrocytes, mesenchymal stem cells, and hematopoietic stem cells, in concert with other cytokines and hormones.
authors: Mucosal Immunology Section, NIDCR, NIH, Bethesda, MD, USA. wchen@dir.nidcr.nih.gov.
authors: Shimpei
authors: S
authors: Kasagi
authors: Wanjun
authors: W
authors: Chen