title: New nicotinic analogue ZY-1 enhances cognitive functions in a transgenic mice model of Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder marked by progressive loss of memory and cognitive function. One of the new approaches for treating AD is direct stimulation of nicotinic acetylcholine receptors (nAChRs) in the brain. α4β2-nAChR agonists have shown promising potential in preclinical cognition models of AD. The present report describes the pharmacological properties of ZY-1, a new nicotinic analogue that activates α4β2-nAChR. We describe in detail the binding profile and pharmacological effects of ZY-1 on transgenic AD mice. ZY-1 has high affinity to α4β2-nAChR. In a Morris water maze test, ZY-1 significantly decreases the escape latency and increases both the times in the platform quadrant and the times of platform crossing of transgenic mice. ZY-1 enhances cognitive functions in transgenic mice models of AD. As a novel nicotinic analogue, ZY-1 deserves further study as a potential candidate against AD.
authors: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
authors: Huizhen
authors: H
authors: Nie
authors: Zejian
authors: Z
authors: Wang
authors: Wenjuan
authors: W
authors: Zhao
authors: Jinmiao
authors: J
authors: Lu
authors: Can
authors: C
authors: Zhang
authors: Kenghoe
authors: K
authors: Lok
authors: Yuliang
authors: Y
authors: Wang
authors: Hanlin
authors: H
authors: Shen
authors: Zheng
authors: Z
authors: Xu
authors: Ming
authors: M
authors: Yin
mesh_terms: D000470:Alkaloids / Q000494:pharmacology; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology; D000818:Animals; D002460:Cell Line; D004924:Escape Reaction; D018782:Maze Learning; D051379:Mice; D008822:Mice, Transgenic; D009538:Nicotine / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D018722:Nicotinic Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D011869:Radioligand Assay; D011930:Reaction Time; D011978:Receptors, Nicotinic / Q000378:metabolism*; D012717:Sesquiterpenes / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D018722:Nicotinic Agonists; D011978:Receptors, Nicotinic; D012717:Sesquiterpenes; C403531:nicotinic receptor alpha4beta2; C050426:huperzine A; D009538:Nicotine