title: Evaluation of GLUT-1 in the granular cell tumour and congenital granular cell epulis.
abstract: BACKGROUND
  The glucose transporter type 1 (GLUT-1) protein is a useful marker for perineurial cells. Because of the possible neuroectodermal histogenesis of the granular cell tumour and congenital granular cell epulis, the aim of this study was to assess the immunoexpression of GLUT-1 protein in granular cell tumour and congenital granular cell epulis to aid in clarifying their histogenesis.
  
  
  METHODS
  The protocol of this study was approved by the Committee of Bioethics in Research at Universidade Federal Minas Gerais. Six cases of granular cell tumour and three cases of congenital granular cell epulis were submitted to immunohistochemistry for GLUT-1 and S-100 using the streptavidin-biotin standard protocol.
  
  
  RESULTS
  Five cases of granular cell tumour were located on the tongue and one case on the upper lip. All cases of congenital granular cell epulis were observed in the alveolar ridge of newborns. All lesions evaluated proved to be immunonegative for GLUT-1. S-100 was found to be positive in all granular cell tumours and negative in congenital granular cell epulis.
  
  
  CONCLUSIONS
  Neither granular cell tumour nor congenital granular cell epulis is directly related to perineurial cells.
authors: Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. grsouto@hotmail.com
authors: Giovanna Ribeiro
authors: GR
authors: Souto
authors: Patrícia Carlos
authors: PC
authors: Caldeira
authors: Aline Cristina Batista Rodrigues
authors: AC
authors: Johann
authors: Helenicede
authors: H
authors: Andrade Marigo
authors: Suzana Cantanhede Orsini Machadode
authors: SC
authors: Souza
authors: Ricardo Alves
authors: RA
authors: Mesquita
mesh_terms: D000328:Adult; D005260:Female; D005887:Gingival Neoplasms / Q000151:congenital* / Q000473:pathology; D051272:Glucose Transporter Type 1 / Q000032:analysis*; D016586:Granular Cell Tumor / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D008048:Lip Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D054258:Neural Plate / Q000473:pathology; D010525:Peripheral Nerves / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D014062:Tongue Neoplasms / Q000473:pathology
chemical_list: D051272:Glucose Transporter Type 1; D009418:S100 Proteins; C495677:SLC2A1 protein, human
keywords: GLUT-1 protein; congenital epulis; granular cell tumour; immunohistochemistry