title: Long-Term Oral Administration of Capsicum baccatum Extracts Does Not Alter Behavioral, Hematological, and Metabolic Parameters in CF1 Mice.
abstract: Our group showed that crude ethanol (CE) and butanol (BUT) extracts of Capsicum baccatum presented anti-inflammatory and antioxidant properties. Furthermore, the flavonoid and total phenolic contents were positively correlated with both of these properties observed for C. baccatum extracts. The present study demonstrated that 60 days of oral administration of CE and BUT (200 mg/kg) in mice did not cause significant differences in the following parameters evaluated: hematological profile, body weight and relative weight of visceral organs, systemic lipid profile, glucose homeostasis (GTT), kidney and hepatic biochemical markers, and spontaneous locomotion and anxiety-like behavior. Altogether, these results indicate for the first time that the long-term oral administration of C. baccatum extracts does not affect specific aspects of CF1 mice physiology, suggesting their safety, building up the venue to test their efficacy in animal models underlying persistent activation of oxidative and inflammatory pathways.
authors: Pharmaceutical Sciences Graduate Program, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Ipiranga Avendia 2752, 90610-000 Porto Alegre, RS, Brazil.
authors: Aline Rigon
authors: AR
authors: Zimmer
authors: Bianca
authors: B
authors: Leonardi
authors: Eduardo Rigon
authors: ER
authors: Zimmer
authors: Eduardo
authors: E
authors: Kalinine
authors: Diogo Onofre
authors: DO
authors: de Souza
authors: Luis Valmor
authors: LV
authors: Portela
authors: Grace
authors: G
authors: Gosmann