title: Negative effects of transfused blood components after hepatectomy for metastatic colorectal cancer.
abstract: There has been conflicting evidence regarding negative effects of blood transfusion in oncology patients. This study was undertaken to determine any negative effects of specific blood product transfusion after resection of hepatic colorectal metastases (CRM). Retrospective review of  patients undergoing hepatectomy for CRM from 1995 to 2009 at a single institution was performed. Specific attention was paid to the effect of blood transfusion within 30 days of operation on overall survival, disease-free survival (DFS), and complications. To mitigate the bias introduced by  complications that require blood transfusion to treat, only nonbleeding complications were considered. Complications were analyzed with univariate and multivariate logistic regression. Survival was analyzed according to Kaplan-Meier and Cox proportional hazards. There were 239 patients included  in the study. There were 64 (26.8%) receiving a transfusion of any kind with 25.5 per cent getting red cells (PRBCs), 7.11 per cent getting fresh-frozen plasma, and 3.77 per cent getting platelets. Multivariate analysis revealed only PRBC transfusion to be independently associated with nonbleeding  complications (odds ratio, 1.980; 95% confidence interval, 1.094 to 3.582; P = 0.0239). There was no significant adverse effect of transfusion with any product on overall or DFS. PRBC transfusion appears to increase the risk of postoperative complications; thus, strategies to minimize  blood use may be warranted.
authors: Department of Surgery, Division of Surgical Oncology, University of Louisville, Louisville, Kentucky 40202, USA.
authors: Robert M
authors: RM
authors: Cannon
authors: Russell E
authors: RE
authors: Brown
authors: Charles R
authors: CR
authors: St Hill
authors: Eric
authors: E
authors: Dunki-Jacobs
authors: Robert C G
authors: RC
authors: Martin
authors: Kelly M
authors: KM
authors: McMasters
authors: Charles R
authors: CR
authors: Scoggins
mesh_terms: D000368:Aged; D016913:Blood Component Transfusion / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000473:pathology*; D006498:Hepatectomy / Q000401:mortality; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D011182:Postoperative Care / Q000009:adverse effects*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome