title: The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder.
abstract: BACKGROUND
  The most effective treatment for posttraumatic stress disorder (PTSD) is exposure therapy, which aims to facilitate extinction of conditioned fear. Recent evidence suggests that brain-derived neurotrophic factor (BDNF) facilitates extinction learning. This study assessed whether the Met-66 allele of BDNF, which results in lower activity-dependent secretion, predicts poor response to exposure therapy in PTSD.
  
  
  METHODS
  Fifty-five patients with PTSD underwent an 8-week exposure-based cognitive behavior therapy program and provided mouth swabs or saliva to extract genomic DNA to determine their BDNF Val66Met genotype (30 patients with the Val/Val BDNF allele, 25 patients with the Met-66 allele). We examined whether BDNF genotype predicted reduction in PTSD severity following exposure therapy.
  
  
  RESULTS
  Analyses revealed poorer response to exposure therapy in the PTSD patients with the Met-66 allele of BDNF compared with patients with the Val/Val allele. Pretreatment Clinician Administered PTSD Scale severity and BDNF Val66Met polymorphism predicted response to exposure therapy using hierarchical regression.
  
  
  CONCLUSIONS
  This study provides the first evidence that the BDNF Val66Met genotype predicts response to cognitive behavior therapy in PTSD and is in accord with evidence that BDNF facilitates extinction learning.
authors: School of Psychology, University of Tasmania, Hobart, TAS 7005, Australia. Kim.Felmingham@utas.edu.au
authors: Kim L
authors: KL
authors: Felmingham
authors: Carol
authors: C
authors: Dobson-Stone
authors: Peter R
authors: PR
authors: Schofield
authors: Gregory J
authors: GJ
authors: Quirk
authors: Richard A
authors: RA
authors: Bryant
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007171:Implosive Therapy / Q000379:methods*; D008297:Male; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests; D012044:Regression Analysis; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics* / Q000534:rehabilitation*; D015599:Trauma Severity Indices; D016896:Treatment Outcome; D014633:Valine / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine