title: Combined intravenous and intraventricular administration of colistin methanesulfonate in critically ill patients with central nervous system infection.
abstract: Colistin pharmacokinetics were prospectively studied after intravenous administration of colistin methanesulphonate in critically ill patients without central nervous system infection (controls, n = 5) and in patients with external ventricular drain-associated ventriculitis after intravenous administration (EVDViv, n = 3) or combined intravenous/intraventricular administration (EVDVcomb, n = 4). Cerebrospinal fluid (CSF)/serum colistin concentration ratios were higher in EVDViv than in control patients (11% versus 7%, P ≤ 0.05) and in EVDVcomb compared to all other patients (P < 0.0001). CSF colistin concentrations above the MIC of 0.5 μg/ml were achieved only in EVDVcomb patients.
authors: Critical Care Department, University Hospital of Larissa, Larissa, Greece.
authors: Mairi
authors: M
authors: Ziaka
authors: Sophia L
authors: SL
authors: Markantonis
authors: Marizoza
authors: M
authors: Fousteri
authors: Paris
authors: P
authors: Zygoulis
authors: Dimitris
authors: D
authors: Panidis
authors: Marios
authors: M
authors: Karvouniaris
authors: Demosthenes
authors: D
authors: Makris
authors: Epaminondas
authors: E
authors: Zakynthinos
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002494:Central Nervous System Infections / Q000188:drug therapy*; D003091:Colistin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000900:Anti-Bacterial Agents; C004691:colistinmethanesulfonic acid; D003091:Colistin