title: Soluplus-coated colloidal silica nanomatrix system for enhanced supersaturation and oral absorption of poorly water-soluble drugs.
abstract: In this study, a Soluplus-coated colloidal silica nanomatrix (SCCSN) formulation for the entrapment of poorly water-soluble drugs was devised. The maximum supersaturation of the drug-loaded nanomatrix was higher than that of a physical mixture as indicated by the results of in vitro kinetic solubility studies. For atorvastatin calcium, dutasteride, and sorafenib tosylate, there were 2.8-, 326-, and 46.4-fold increases in solubility, respectively. For dutasteride, a promising 4.7-fold increase for in vivo oral drug absorption in the entrapped nanomatrix was observed as compared to the free physical mixture, supported by statistical significance testing of pharmacokinetic parameters.
authors: Department of Pharmaceutical Engineering, Inje University , Gimhae, Gyeongnam , Republic of Korea.
authors: Min-Soo
authors: MS
authors: Kim
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D000069059:Atorvastatin; D003102:Colloids; D004337:Drug Carriers / Q000737:chemistry*; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry* / Q000378:metabolism* / Q000493:pharmacokinetics; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011758:Pyrroles / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry* / Q000378:metabolism* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D003102:Colloids; D004337:Drug Carriers; D006538:Heptanoic Acids; D011145:Polyvinyls; D011758:Pyrroles; C572167:polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; D014867:Water; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D000069059:Atorvastatin