title: Development of gadolinium based nanoparticles having an affinity towards melanin.
abstract: Small Rigid Platforms (SRPs) are sub-5 nanometre gadolinium based nanoparticles that have been developed for multimodal imaging and theranostic applications. They are composed of a polysiloxane network surrounded by gadolinium chelates. A covalent coupling with quinoxaline derivatives has been performed. Such derivatives have proven their affinity for melanin frequently expressed in primary melanoma cases. Three different quinoxaline derivatives have been synthesised and coupled to the nanoparticles. The affinity of the grafted nanoparticles for melanin has then been shown in vitro by surface plasmon resonance on a homemade melanin grafted gold chip.
authors: Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS - Université Claude Bernard Lyon 1, Université de Lyon, 69622 Villeurbanne Cedex, France.
authors: Jessica
authors: J
authors: Morlieras
authors: Jean-Michel
authors: JM
authors: Chezal
authors: Elisabeth
authors: E
authors: Miot-Noirault
authors: Amandine
authors: A
authors: Roux
authors: Laurence
authors: L
authors: Heinrich-Balard
authors: Richard
authors: R
authors: Cohen
authors: Sébastien
authors: S
authors: Tarrit
authors: Charles
authors: C
authors: Truillet
authors: Anna
authors: A
authors: Mignot
authors: Roxanne
authors: R
authors: Hachani
authors: David
authors: D
authors: Kryza
authors: Rodolphe
authors: R
authors: Antoine
authors: Philippe
authors: P
authors: Dugourd
authors: Pascal
authors: P
authors: Perriat
authors: Marc
authors: M
authors: Janier
authors: Lucie
authors: L
authors: Sancey
authors: François
authors: F
authors: Lux
authors: Olivier
authors: O
authors: Tillement
mesh_terms: D001665:Binding Sites; D005682:Gadolinium / Q000737:chemistry*; D008422:Materials Testing; D008543:Melanins / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D008543:Melanins; D005682:Gadolinium