title: Adjuvant methods to improve results of local bladder irrigations by chemotherapy for NMIBC.
abstract: Non-muscle-invasive bladder cancer is characterized by frequent recurrences requiring repeated transurethral resections and carries a risk of progression to muscle-invasive disease. The routinely used, passive diffusion irrigation of the bladder with mitomycin C has achieved limited success in avoiding these events. We review two methods that may improve penetration of mitomycin C into the bladder wall, thus leading to better results in terms of recurrence rate and bladder preservation.
authors: Department of Urology, Carmel Medical Centre, 7 Michal Street, Haifa, Israel. Yuvalfr@clalit.org.il
authors: Yuval
authors: Y
authors: Freifeld
authors: Yoram
authors: Y
authors: Dekel
authors: Avi
authors: A
authors: Stein
mesh_terms: D000283:Administration, Intravesical; D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000473:pathology; D003131:Combined Modality Therapy; D004599:Electric Stimulation Therapy / Q000379:methods; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008872:Microwaves / Q000627:therapeutic use; D016685:Mitomycin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology; D019459:Urothelium / Q000378:metabolism
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin