title: [Influence of corneal biomechanical properties on myopic regression after laser in situ keratomileusis].
abstract: BACKGROUND
  Laser in situ keratomileusis is a safe and accepted method for correcting myopia. The operational results in terms of accuracy as well as the subjective acceptance of patients for corrections to - 8 D are now considered to be promising (Seiler, Refraktive Chirurgie der Hornhaut, 2000); however, postoperative results show individual patient problems in long-term stability. It is believed that the preoperative condition of the cornea (e.g. thickness, biomechanical properties) could have an influence on postoperative problems such as myopic regression.
  
  
  METHODS
  This study included a total of 46 eyes from 25 patients. At 3 months postoperatively, 15 patients (19 eyes) showed a SEQ of -0.50 D or more. Within this group, 11 patients (15 eyes) developed a regression (regression group) within the first 3 postoperative months. The remainder of the total group did not show any regression (stability group). The subjects of this study were on average 33 ± 8 years (stability group) and 31 ± 7 years old (regression group). The corneal thickness was tested and refractive error, visual acuity (BCVA/UCVA) and intraocular pressure was measured. In addition, the corneal hysteresis (CH) and corneal resistance factor (CRF) were determined.
  
  
  RESULTS
  The mean preoperative spherical equivalent refraction was -3.14 D ± 1.41 D (SE) in the stability group and - 6.47 D ± 1.40 D (p = 0.001)in the regression group. Also, the postoperative spherical equivalents were statistically significant different (p < 0.05). In contrast, the mean preoperative corneal thickness showed no differences in both groups (p = 0.96) (stability group 563 ± 36 µm and regression group 563 ± 28 µm).
  
  
  CONCLUSIONS
  The aim of the study to detect a possible causal relationship between myopia regression after LASIK and the biomechanical properties of the cornea and corneal thickness could not be clearly identified.
authors: Augenklinik Bellevue, Lindenallee 21, 24105 Kiel. d.uthoff@augenklinik-bellevue.de
authors: D
authors: D
authors: Uthoff
authors: K
authors: K
authors: Hebestedt
authors: G I W
authors: GI
authors: Duncker
authors: E
authors: E
authors: Spörl
mesh_terms: D000328:Adult; D003315:Cornea / Q000503:physiopathology* / Q000601:surgery*; D055119:Elastic Modulus; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D020731:Keratomileusis, Laser In Situ; D008297:Male; D008954:Models, Biological; D009216:Myopia / Q000503:physiopathology* / Q000601:surgery*; D020127:Recovery of Function; D012008:Recurrence; D012031:Refractometry; D016896:Treatment Outcome