title: Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems.
abstract: Lipid vesicles have received significant attention in areas ranging from pharmaceutical and biomedical engineering to novel materials and nanotechnology. Microfluidic-based synthesis of liposomes offers a number of advantages over the more traditional synthesis methods such as extrusion and sonication. One such microfluidic approach is microfluidic hydrodynamic focusing (MHF), which has been used to synthesize nanoparticles and vesicles of various lipids. We show here that this method can be utilized in synthesis of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) vesicles with controllable size. Since POPC is among the primary constituents of cellular membranes, this work is of direct applicability to modelling of biological systems and development of nano-containers with higher biologic compatibility for pharmaceutical and medical applications.
authors: School of Chemical Engineering, The University of Adelaide, Adelaide 5005, SA, Australia.
authors: M
authors: M
authors: Mijajlovic
authors: D
authors: D
authors: Wright
authors: V
authors: V
authors: Zivkovic
authors: J X
authors: JX
authors: Bi
authors: M J
authors: MJ
authors: Biggs
mesh_terms: D057446:Hydrodynamics; D008081:Liposomes / Q000138:chemical synthesis / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques; D008954:Models, Biological; D010316:Particle Size; D010713:Phosphatidylcholines / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008081:Liposomes; D010713:Phosphatidylcholines; C028694:1-palmitoyl-2-oleoylphosphatidylcholine