title: [Effect of 3-oxypyridine and succinic acid derivatives on affective status in recrudescence of inflammatory diseases of uterus and its appendages].
abstract: Short-term, prospective placebo-controlled simple blind randomized study of the effects of 3-oxypyridine and succinic acid derivatives (emoxipin, reamberin, mexidol) on the affective status of females with recrudescence of the inflammatory diseases of uterus and its appendages (IDUA) in comparison to changes of systemic inflammatory response (SIR) markers level in the blood has been conducted. It is established that the inclusion of emoxipin, reamberin and mexidol in complex treatment of IDUA recrudescence reduce depression, anxiety and SIR laboratory signs. Mexidol being both 3-oxypyridine and succinic acid derivative showed the best influence on the dynamics of affective disorders and SIR changes.
authors: I A
authors: IA
authors: Volchegorskiĭ
authors: E V
authors: EV
authors: Pravdin
authors: T V
authors: TV
authors: Uzlova
mesh_terms: D000290:Adnexa Uteri / Q000187:drug effects / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000276:immunology; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D053583:Interleukin-1beta / Q000097:blood; D008536:Meglumine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D010587:Phagocytosis; D010847:Picolines / Q000494:pharmacology* / Q000627:therapeutic use; D011446:Prospective Studies; D011725:Pyridines / Q000494:pharmacology* / Q000627:therapeutic use; D012008:Recurrence; D013386:Succinates / Q000494:pharmacology / Q000627:therapeutic use; D019802:Succinic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014599:Uterus / Q000187:drug effects / Q000276:immunology
chemical_list: C457919:3-oxypyridine; D000975:Antioxidants; D053583:Interleukin-1beta; D010847:Picolines; D011725:Pyridines; C549374:Reamberin; D013386:Succinates; D014409:Tumor Necrosis Factor-alpha; C070020:emoxypine succinate; D008536:Meglumine; D019802:Succinic Acid; C009820:6-methyl-2-ethyl-3-hydroxypyridine