title: Diastereoselective intramolecular allyl transfer from allyl carbamate accompanied by 5-endo-trig ring closure.
abstract: To All(oc) involved: A palladium-catalyzed formal 5-endo-trig heteroannulation of enones generated in situ from amino acid derived β-keto nitriles has been realized (see scheme; Alloc=allyl carbamate). The reaction proceeds with allyl-group transfer from the carbamate protecting group to generate two new contiguous stereocenters, including one quaternary center, with high selectivity.
authors: Aalto University, School of Chemical Technology, P. O. Box 16100, 00076 AALTO, Finland.
authors: Oskari K
authors: OK
authors: Karjalainen
authors: Martin
authors: M
authors: Nieger
authors: Ari M P
authors: AM
authors: Koskinen