title: Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy.
abstract: Obesity is associated with an increased risk of acute lymphoblastic leukemia (ALL) relapse. Using mouse and cell co-culture models, we investigated whether adipose tissue attracts ALL to a protective microenvironment. Syngeneically implanted ALL cells migrated into adipose tissue within ten days. In vitro, murine ALL cells migrated towards adipose tissue explants and 3T3-L1 adipocytes. Human and mouse ALL cells migrated toward adipocyte conditioned media, which was mediated by SDF-1α. In addition, adipose tissue explants protected ALL cells against daunorubicin and vincristine. Our findings suggest that ALL migration into adipose tissue could contribute to drug resistance and potentially relapse.
authors: Center for Endocrinology, Diabetes & Metabolism, Children's Hospital Los Angeles, CA, USA.
authors: Rocky
authors: R
authors: Pramanik
authors: Xia
authors: X
authors: Sheng
authors: Brian
authors: B
authors: Ichihara
authors: Nora
authors: N
authors: Heisterkamp
authors: Steven D
authors: SD
authors: Mittelman
mesh_terms: D041721:3T3-L1 Cells; D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D054377:Chemokine CXCL12 / Q000378:metabolism; D003630:Daunorubicin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014185:Transplantation, Isogeneic; D059016:Tumor Microenvironment / Q000187:drug effects*; D014750:Vincristine / Q000494:pharmacology*
chemical_list: D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D054377:Chemokine CXCL12; C515256:Cxcl12 protein, mouse; D014750:Vincristine; D003630:Daunorubicin