title: Consumption of vitamin B(6) reduces fecal ratio of lithocholic acid to deoxycholic acid, a risk factor for colon cancer, in rats fed a high-fat diet.
abstract: To examine the effect of supplemental dietary vitamin B(6) on the colonic luminal environment, growing male rats were fed a high-fat diet containing 1, 7, or 35 mg pyridoxine HCl/kg diet for 6 wk. Food intake and growth were unaffected by the dietary treatment. Supplemental dietary vitamin B(6) significantly reduced the production of a fecal secondary bile acid, lithocholic acid (the most toxic secondary bile acid and a risk factor for colon cancer), and markedly reduced the ratio of lithocholic acid to deoxycholic acid (a less toxic secondary bile acid) in feces (p<0.05). Increasing dietary vitamin B(6) increased fecal mucin levels (a marker of intestinal barrier function) in a dose-dependent manner (p<0.05) but did not affect fecal immunoglobulin A levels (an index of intestinal immune function). Cecal levels of organic acids were not significantly affected by supplemental dietary vitamin B(6). These results suggest the possibility that dietary vitamin B(6) affects the colonic luminal environment by altering the production of secondary bile acids and mucins.
authors: Faculty of Human Life Sciences, Fuji Women's University, Ishikari, Japan. yokazaki@fujijoshi.ac.jp
authors: Yukako
authors: Y
authors: Okazaki
authors: Zaki
authors: Z
authors: Utama
authors: Sofya
authors: S
authors: Suidasari
authors: Peipei
authors: P
authors: Zhang
authors: Noriyuki
authors: N
authors: Yanaka
authors: Hiroyuki
authors: H
authors: Tomotake
authors: Ei
authors: E
authors: Sakaguchi
authors: Norihisa
authors: N
authors: Kato
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D002432:Cecum / Q000187:drug effects / Q000503:physiopathology; D003106:Colon / Q000187:drug effects / Q000503:physiopathology; D003110:Colonic Neoplasms / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D003840:Deoxycholic Acid / Q000032:analysis*; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage; D005243:Feces / Q000737:chemistry*; D008095:Lithocholic Acid / Q000032:analysis*; D008297:Male; D009077:Mucins / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors; D025101:Vitamin B 6 / Q000008:administration & dosage*
chemical_list: D001647:Bile Acids and Salts; D004041:Dietary Fats; D009077:Mucins; D003840:Deoxycholic Acid; D008095:Lithocholic Acid; D025101:Vitamin B 6