title: Fetal aortic isthmus Doppler measurements for prediction of perinatal morbidity and mortality associated with fetal growth restriction.
abstract: OBJECTIVE
  To identify the role of longitudinal measurements of fetal aortic isthmus blood flow using Doppler ultrasonography in the prediction of perinatal morbidity and mortality.
  
  
  METHODS
  Obstetrics department of a university hospital. POPULATION AND DESIGN: This prospective study includes women with fetal growth restriction and abnormal umbilical artery Doppler results, seen between November 2009 and January 2011.
  
  
  METHODS
  31 women were divided into two groups according to the aortic isthmus blood flow pattern just before birth: anterograde (n = 12) or retrograde (n = 19).
  
  
  METHODS
  Longitudinal measurements of fetal aortic isthmus in relation to perinatal outcome.
  
  
  RESULTS
  Total morbidity and mortality rates were significantly higher in the retrograde flow group. There was no statistically significant difference for respiratory distress syndrome, intraventricular hemorrhage, bronchopulmonary dysplasia or necrotizing enterocolitis, but the neonatal sepsis rate was significantly higher in the retrograde flow group. An abnormal aortic isthmus flow pattern was detected approximately 15-20 days after umbilical artery and middle cerebral artery Doppler flow abnormalities and 3-7 days before deterioration in ductus venosus blood flow.
  
  
  CONCLUSIONS
  We suggest that aortic isthmus Doppler measurements are useful for identifying fetal growth restriction before deterioration in ductus venosus blood flow and fetal acidosis.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Ege University, Bornova, Turkey.
authors: Khalil
authors: K
authors: Abdelrazzaq
authors: Ahmet Özgür
authors: AÖ
authors: Yeniel
authors: Ahmet Mete
authors: AM
authors: Ergenoglu
authors: Nuri
authors: N
authors: Yildirim
authors: Fuat
authors: F
authors: Akercan
authors: Nedim
authors: N
authors: Karadadaş
mesh_terms: D000037:Abruptio Placentae / Q000453:epidemiology; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging* / Q000196:embryology; D001034:Apgar Score; D001783:Blood Flow Velocity / Q000502:physiology; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D020345:Enterocolitis, Necrotizing / Q000453:epidemiology; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging*; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000453:epidemiology; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging; D011247:Pregnancy; D011446:Prospective Studies; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology; D018805:Sepsis / Q000453:epidemiology; D018608:Ultrasonography, Doppler; D014469:Umbilical Arteries / Q000000981:diagnostic imaging; D014471:Umbilical Veins / Q000000981:diagnostic imaging