title: Treatment of hepatitis C: how will we use viral kinetics, response-guided therapy?
abstract: Hepatitis C virus (HCV) RNA level monitoring is currently used to guide the duration of interferon-containing treatment regimens. Nowadays, HCV RNA level quantification is based on real-time polymerase chain reaction assays that are both sensitive and accurate. Assessing the virological response to therapy is used to shorten treatment duration in early responders, in order to reduce the cost and burden of adverse events of therapy without impacting the chance of success. Whether response-guided therapy will still be useful in the era of all-oral, interferon-free regimens remains uncertain.
authors: Department of Virology, Hôpital Henri Mondor, Université Paris-Est, 51 avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France. jean-michel.pawlotsky@hmn.aphp.fr
authors: Jean-Michel
authors: JM
authors: Pawlotsky
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D007700:Kinetics; D008954:Models, Biological; D011092:Polyethylene Glycols / Q000008:administration & dosage; D011480:Protease Inhibitors / Q000008:administration & dosage; D012367:RNA, Viral / Q000097:blood*; D012254:Ribavirin / Q000008:administration & dosage
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D011480:Protease Inhibitors; D012367:RNA, Viral; D011092:Polyethylene Glycols; D012254:Ribavirin