title: Binding of specific ligand by D2- and NMDA-receptors of striatum cells in two rat strains predisposed and resistant to audiogenic seizures.
abstract: We studied parameters of specific receptor binding of D2-dopamine receptor ligand [(3)H]-sulpiride and NMDA-receptor ligand [(3)H]-MK-801 on the membranes of striatum cells in Krushinsky-Molodkina rats (predisposed to audiogenic seizures) and strain "0" selected for the absence of audiogenic seizures. No interstrain differences were observed in affinity (K(d)) of both D2- and NMDA-receptors to ligands. At the same time, significant interstrain differences in receptor density (B(max)) were found for both D2-receptors and NMDA-receptors. The reduced number of dopamine and glutamate receptors in the striatum can be associated with neurological peculiarities of Krushinsky-Molodkina rat strain (audiogenic seizures and postictal catalepsy).
authors: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Russia.
authors: Ju Ju
authors: JJ
authors: Firstova
authors: D A
authors: DA
authors: Abaimov
authors: N M
authors: NM
authors: Surina
authors: I I
authors: II
authors: Poletaeva
authors: I B
authors: IB
authors: Fedotova
authors: G I
authors: GI
authors: Kovalev
mesh_terms: D000818:Animals; D001665:Binding Sites; D003342:Corpus Striatum / Q000166:cytology*; D016291:Dizocilpine Maleate / Q000378:metabolism; D008297:Male; D011485:Protein Binding; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D012640:Seizures / Q000378:metabolism*
chemical_list: D017448:Receptors, Dopamine D2; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate