title: ⁹⁹mTc-(Me)FGCDEVD, a potential tracer for apoptosis detection.
abstract: (Me)FGC(Bz)DEVD was radiolabeled with technetium-99m in high yield. This tracer was preferentially accumulated in apoptotic cells in the in vitro studies. Tumor uptake occurred in vivo after cisplatin injection due to the apoptosis induction, which not observed in the untreated tumors. Therefore, (99m)Tc-(Me)FGCDEVD is a potential tracer for apoptosis detection.
authors: Département de médecine nucléaire, Centre Henri Becquerel, 1 rue d'Amiens, 76038 Rouen Cedex, France. pierre.bohn@chb.unicancer.fr
authors: Pierre
authors: P
authors: Bohn
authors: Florian
authors: F
authors: Mouchard
authors: Jean
authors: J
authors: Rouvet
authors: Anne-Caroline
authors: AC
authors: de Boisgrollier
authors: Pierre
authors: P
authors: Vera
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D064593:Heterografts; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D009842:Oligopeptides / Q000737:chemistry* / Q000187:drug effects / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000493:pharmacokinetics; D017556:Technetium Compounds / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D009842:Oligopeptides; D019275:Radiopharmaceuticals; D017556:Technetium Compounds; D002945:Cisplatin