title: [Prevention of restenosis with a new modified fully-covered retrievable esophageal stent].
abstract: OBJECTIVE
  To observe and evaluate the effectiveness of a new modified fully-covered retrievable esophageal stent in preventing restenosis at the proximal end of the stent.
  
  
  METHODS
  From January 2008 to October 2011, 380 consecutive patients who underwent placement of a conventional stent or a new modified stent for benign or malignant dysphagia were divided into two groups: conventional stent group 193 patients (male 137, female 56) and modified stent group 187 patients (male 125, female 62). The granulation formation and restenosis rate one month after stenting were evaluated. Data such as patient demographics, outcomes and complications were collected. The results were statistically analyzed by Student t test, chi-squared test, Fisher's exact probability or rank sum test. A P-value less than 0.05 was considered statistically significant.
  
  
  RESULTS
  All stents were successfully implanted. They were highly effective in palliating dysphagia. The dysphagia score decreased from 3 (1) to 0 (1) in conventional stent group (P < 0.01), and that from 4 (1) to 0 (1) in modified stent group (P < 0.01). The modified stent group were superior to the conventional stent group in severe granulation formation rate (0 vs 4.7% (9/193), P = 0.004) and restenosis rate (2.7% (5/187) vs 7.3% (14/193), P = 0.041) within one month after stenting, and the modified stent was easier to retrieve. Postoperative remission rate of dysphagia, and complications such as chest pain, bleeding, perforation, stent migration had no statistical differences between the two groups (all P > 0.05).
  
  
  CONCLUSIONS
  The new modified fully-covered retrievable esophageal stent can significantly reduce granulation formation at the proximal end of the stent. Using of this stent seems to be a better choice in treating patient of dysphagia, with lower restenosis rate and easier to retrieve.
authors: Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, China.
authors: Li-juan
authors: LJ
authors: Qian
authors: Lian-zhen
authors: LZ
authors: Yu
authors: Bin
authors: B
authors: Wang
authors: Jing
authors: J
authors: Ding
authors: Li
authors: L
authors: Chen
authors: Shun-fu
authors: SF
authors: Xu
authors: Jing
authors: J
authors: Zhao
authors: Rui-hua
authors: RH
authors: Shi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000497:Alloys; D002648:Child; D004937:Esophageal Fistula / Q000601:surgery*; D004940:Esophageal Stenosis / Q000517:prevention & control* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure; D015607:Stents; D055815:Young Adult
chemical_list: D000497:Alloys