title: Palladium- and nickel-catalyzed alkenylation of enolates.
abstract: Transition-metal-catalyzed alkenylation of enolates provides a direct method to synthesize broadly useful β,γ-unsaturated carbonyl compounds from the corresponding carbonyl compound and alkenyl halides. Despite being reported in the early seventies, this reaction class saw little development for many years. In the past decade, however, efforts to develop this reaction further have increased considerably, and many research groups have reported efficient coupling protocols, including enantioselective versions. These reactions most commonly employ palladium catalysts, but there are also some important reports using nickel. There are many examples of this powerful transformation being used in the synthesis of complex natural products.
authors: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden.
authors: Tobias
authors: T
authors: Ankner
authors: Casey C
authors: CC
authors: Cosner
authors: Paul
authors: P
authors: Helquist
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D000475:Alkenes; D001688:Biological Products; D002264:Carboxylic Acids; D007659:Ketones; D028561:Transition Elements; D010165:Palladium; D009532:Nickel