title: Association of the 5HTR2A gene with suicidal behavior: case-control study and updated meta-analysis.
abstract: BACKGROUND
  The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present study was to examine the association between T102C with suicidal behavior in a case-control study and, to assess the combined evidence - this case-control study and available data from other related studies - we carried out a meta-analysis.
  
  
  METHODS
  We conducted a case-control study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia.
  
  
  RESULTS
  We found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case-control study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09).
  
  
  CONCLUSIONS
  Our results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case-control study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.
authors: División Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México.
authors: Thelma Beatriz
authors: TB
authors: González-Castro
authors: Carlos
authors: C
authors: Tovilla-Zárate
authors: Isela
authors: I
authors: Juárez-Rojop
authors: Sherezada
authors: S
authors: Pool García
authors: Martha Patricia
authors: MP
authors: Velázquez-Sánchez
authors: Alma
authors: A
authors: Genis
authors: Humberto
authors: H
authors: Nicolini
authors: Lilia
authors: L
authors: López Narváez
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D013406:Suicide, Attempted / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D044402:Receptor, Serotonin, 5-HT2A