title: [Treatment of hyperthyroidism due to Graves' disease: what is the recommended antithyroid drug during pregnancy?].
abstract: Clinical hyperthyroidism during the first trimester of pregnancy due to Graves' disease can be associated with maternal, obstetrical and fetal complications, indicating an active treatment to restore normal thyroid function. Antithyroid drugs are the first line treatment in pregnant women with hyperthyroidism. Due to the increased congenital malformations reported in neonates after first-trimester carbimazole/methimazole treatment and propylthiouracil associated hepatotoxicity, the recommended treatment for pregnant women with hyperthyroid Graves' disease is propylthiouracil during the first trimester of pregnancy and following the first trimester, consideration should be given switching to carbimazole/methimazole during the second part of gestation.
authors: Service d'endocrinologie, maladies métaboliques et nutrition, pôle cardiovasculaire et métabolique, CHU de Larrey et Toulouse, 24, chemin de Pouvourville, TSA 30030, 31059, Toulouse, France. caron.p@chu-toulouse.fr
authors: P
authors: P
authors: Caron
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D013956:Antithyroid Agents / Q000627:therapeutic use*; D002755:Choice Behavior; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000453:epidemiology; D011364:Professional Practice / Q000706:statistics & numerical data
chemical_list: D013956:Antithyroid Agents