title: IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus.
abstract: Immune responses to vaccines require direct recognition of pathogen-associated molecular patterns (PAMPs) through pattern-recognition receptors (PRRs) on dendritic cells (DCs). Unlike vaccination, infection by a live pathogen often impairs DC function and inflicts additional damage on the host. Here we found that after infection with live influenza A virus, signaling through the interleukin 1 receptor (IL-1R) was required for productive priming of CD8(+) T cells, but signaling through the PRRs TLR7 and RIG-I was not. DCs activated by IL-1 in trans were both required and sufficient for the generation of virus-specific CD8(+) T cell immunity. Our data demonstrate a critical role for a bystander cytokine in the priming of CD8(+) T cells during infection with a live virus.
authors: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
authors: Iris K
authors: IK
authors: Pang
authors: Takeshi
authors: T
authors: Ichinohe
authors: Akiko
authors: A
authors: Iwasaki
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D002454:Cell Differentiation; D002465:Cell Movement; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D009980:Influenza A virus / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D053594:Myeloid Differentiation Factor 88 / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009976:Orthomyxoviridae Infections / Q000276:immunology; D054400:Receptors, CCR7 / Q000096:biosynthesis; D011956:Receptors, Cell Surface; D017472:Receptors, Interleukin-1 / Q000235:genetics / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D051199:Toll-Like Receptor 7 / Q000378:metabolism; D000097905:Roundabout Proteins
chemical_list: D007375:Interleukin-1; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D053594:Myeloid Differentiation Factor 88; D009419:Nerve Tissue Proteins; D054400:Receptors, CCR7; D011956:Receptors, Cell Surface; D017472:Receptors, Interleukin-1; D051192:Receptors, Pattern Recognition; D051199:Toll-Like Receptor 7; C515371:Ccr7 protein, mouse; C507780:Myd88 protein, mouse; C118348:Robo3 protein, mouse; D000097905:Roundabout Proteins; C477038:Tlr7 protein, mouse