title: Antiretroviral therapy initiated during acute HIV infection fails to prevent persistent T-cell activation.
abstract: Initiation of antiretroviral therapy during acute HIV-1 infection may prevent persistent immune activation. We analyzed longitudinal CD38+HLA-DR+ CD8+ T-cell percentages in 31 acutely infected individuals who started early (median 43 days since infection) and successful antiretroviral therapy, and maintained viral suppression through 96 weeks. Pretherapy a median of 72.6% CD8+ T cells were CD38+HLA-DR+, and although this decreased to 15.6% by 96 weeks, it remained substantially higher than seronegative controls (median 8.9%, P = 0.008). Shorter time to suppression predicted lower activation at 96 weeks. These results support the hypothesis that very early events in HIV-1 pathogenesis may result in prolonged immune dysfunction.
authors: Department of Medicine, Center for Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. mjv@med.unc.edu
authors: Michael J
authors: MJ
authors: Vinikoor
authors: Anna
authors: A
authors: Cope
authors: Cynthia L
authors: CL
authors: Gay
authors: Guido
authors: G
authors: Ferrari
authors: Kara S
authors: KS
authors: McGee
authors: Joann D
authors: JD
authors: Kuruc
authors: Jeffrey L
authors: JL
authors: Lennox
authors: David M
authors: DM
authors: Margolis
authors: Charles B
authors: CB
authors: Hicks
authors: Joseph J
authors: JJ
authors: Eron
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects* / Q000276:immunology* / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load / Q000276:immunology; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral