title: Bipyrene-functionalized graphene as a "turn-on" fluorescence sensor for manganese(II) ions in living cells.
abstract: 1,2-bis-(2-pyren-1-ylmethylamino-ethoxy) ethane (NPEY) was synthesized and brought to the surface of graphene nanosheets (GNs) via π-π stacking, which provided a simple and convenient route for processing "turn-on" fluorescent sensor by simply mixing the diluted aqueous solutions of both components. The synthesized NPEY modified graphene nanosheets (NPEY-GNs) not only allows good selectivity toward Mn(2+) with the detection limit of 4.6 × 10(-5) M, but also shows "turn-on" response for Mn(2+) both in vitro and in living cells. These sensing capabilities of NPEY-GNs in living cells make it a robust candidate for many biological fields, such as intracellular tracking, intracellular imaging, etc.
authors: Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China.
authors: Xiaowei
authors: X
authors: Mao
authors: Haiyan
authors: H
authors: Su
authors: Demei
authors: D
authors: Tian
authors: Haibing
authors: H
authors: Li
authors: Ronghua
authors: R
authors: Yang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D005453:Fluorescence; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D057230:Limit of Detection; D008345:Manganese / Q000032:analysis*; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D011108:Polymers; D008345:Manganese; D006108:Graphite