title: The immune system's involvement in obesity-driven type 2 diabetes.
abstract: Type 2 diabetes is now a worldwide epidemic, strongly correlated with an elevated incidence of obesity. Obesity-associated adipose tissue inflammation is a major cause of the decreased insulin sensitivity seen in type 2 diabetes. Recent studies have shed light on the cross-talk between the immune system and organismal metabolism. This review discusses the connection between inflammation in adipose tissue and systemic insulin resistance, focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this metabolic disease.
authors: Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, United States.
authors: Chengyi Jenny
authors: CJ
authors: Shu
authors: Christophe
authors: C
authors: Benoist
authors: Diane
authors: D
authors: Mathis
mesh_terms: D000273:Adipose Tissue / Q000276:immunology; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007333:Insulin Resistance; D051379:Mice; D009765:Obesity / Q000276:immunology* / Q000503:physiopathology*