title: 14-Membered macrocyclic ring-derived toolbox: the identification of small molecule inhibitors of angiogenesis and early embryo development in zebrafish assay.
abstract: A highly practical and modular synthesis to obtain a diverse 14-membered ring-based macrocyclic toolbox is achieved. These compounds were further tested in zebrafish assays related to early embryonic development, angiogenesis, and neurogenesis, respectively. 1.4c was identified as an antiangiogenesis agent.
authors: Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India.
authors: Madhu
authors: M
authors: Aeluri
authors: Chinmoy
authors: C
authors: Pramanik
authors: Lakshindra
authors: L
authors: Chetia
authors: Naveen Kumar
authors: NK
authors: Mallurwar
authors: Sridhar
authors: S
authors: Balasubramanian
authors: Gayathri
authors: G
authors: Chandrasekar
authors: Satish Srinivas
authors: SS
authors: Kitambi
authors: Prabhat
authors: P
authors: Arya
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D015195:Drug Design; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009024:Morphogenesis / Q000187:drug effects; D009389:Neovascularization, Pathologic; D011247:Pregnancy; D013329:Structure-Activity Relationship; D015027:Zebrafish / Q000196:embryology
chemical_list: D020533:Angiogenesis Inhibitors; D047028:Macrocyclic Compounds