title: Molecular diagnostics complementing morphology in superficial mesenchymal tumors.
abstract: Molecular techniques are increasingly important in the practice of surgical pathology. In soft tissue tumors, there are a number of tumors with recurring cytogenetic abnormalities. Knowledge of these abnormalities has furthered our understanding of these tumors and has also allowed development of molecular techniques to aid in the diagnosis. This review will focus on mesenchymal tumors with specific cytogenetic abnormalities that may present as a superficial tumor of the dermis or subcutis.
authors: Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA.
authors: Alison L
authors: AL
authors: Cheah
authors: John R
authors: JR
authors: Goldblum
authors: Steven D
authors: SD
authors: Billings
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001859:Bone Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis; D018223:Dermatofibrosarcoma / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D005208:Fasciitis / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D005354:Fibrosarcoma / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D006394:Hemangiosarcoma / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D051677:Histiocytoma, Malignant Fibrous / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008648:Mesoderm / Q000473:pathology*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D018227:Sarcoma, Clear Cell / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D015514:Oncogene Proteins, Fusion