title: Circulating prolactin associates with diabetes and impaired glucose regulation: a population-based study.
abstract: OBJECTIVE
  Prolactin is a major stimulus for the β-cell adaptation during gestation and guards postpartum women against gestational diabetes. Most studies of the role of prolactin on glucose metabolism have been conducted in humans and animals during pregnancy. However, little is known concerning the association between circulating prolactin and glucose metabolism outside pregnancy in epidemiological studies. We aimed to determine whether the variation of circulating prolactin concentration associates with diabetes and impaired glucose regulation (IGR) in a cross-sectional study.
  
  
  METHODS
  We recruited 2,377 participants (1,034 men and 1,343 postmenopausal women) without hyperprolactinemia, aged 40 years and older, in Shanghai, China. Diabetes and IGR were determined by an oral glucose tolerance test. Multinomial logit analyses were performed to evaluate the relationship of prolactin with diabetes and IGR.
  
  
  RESULTS
  Prolactin levels decreased from normal glucose regulation to IGR to diabetes. Multinomial logit analyses, adjusted for potential confounding factors, showed that high circulating prolactin was associated with lower prevalence of diabetes and IGR. The adjusted odds ratios (95% CI) for IGR and diabetes for the highest compared with the lowest quartile of prolactin were 0.54 (95% CI 0.33-0.89) and 0.38 (0.24-0.59) in men and 0.54 (0.36-0.81) and 0.47 (0.32-0.70) in women.
  
  
  CONCLUSIONS
  High circulating prolactin associates with lower prevalence of diabetes and IGR in the current study. Further studies are warranted to confirm this association.
authors: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China.
authors: Tiange
authors: T
authors: Wang
authors: Jieli
authors: J
authors: Lu
authors: Yu
authors: Y
authors: Xu
authors: Mian
authors: M
authors: Li
authors: Jichao
authors: J
authors: Sun
authors: Jie
authors: J
authors: Zhang
authors: Baihui
authors: B
authors: Xu
authors: Min
authors: M
authors: Xu
authors: Yuhong
authors: Y
authors: Chen
authors: Yufang
authors: Y
authors: Bi
authors: Weiqing
authors: W
authors: Wang
authors: Guang
authors: G
authors: Ning
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*
chemical_list: D011388:Prolactin