title: Nickel-mediated inter- and intramolecular C-S coupling of thiols and thioacetates with aryl iodides at room temperature.
abstract: A Ni(0)-catalyzed intermolecular cross-coupling of various functionalized thiols and aryl iodides has been developed and successfully extended to less explored intramolecular versions, where thioacetates could also be utilized as the strategic surrogate. Air-stable precatalysts, very mild conditions, and an easy protocol allow rapid access to medicinally useful aryl thioethers, as demonstrated in the facile synthesis of (±)-chuangxinmycin as a key step.
authors: State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
authors: Xiao-Bo
authors: XB
authors: Xu
authors: Jian
authors: J
authors: Liu
authors: Jian-Jian
authors: JJ
authors: Zhang
authors: Ya-Wen
authors: YW
authors: Wang
authors: Yu
authors: Y
authors: Peng
mesh_terms: D002384:Catalysis; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013440:Sulfides; D013696:Temperature
chemical_list: D006847:Hydrocarbons, Iodinated; D007211:Indoles; D013438:Sulfhydryl Compounds; D013440:Sulfides; C014414:chuangxinmycin; D009532:Nickel