title: The response of the anophthalmic socket to prosthetic eye wear.
abstract: OBJECTIVE
  The aim of this study was to investigate the inflammatory response of the anophthalmic socket to prosthetic eye wear.
  
  
  METHODS
  One hundred and two prosthetic eye wearers were recruited for this observational study. Photographic grading scales were used to measure the severity of conjunctival inflammation and the extent and intensity of stained deposits on the prosthetic eyes. Tear volume was measured with the phenol red thread test. For mucoid discharge, visual analogue scales were used to assess frequency of occurrence, colour, volume and viscosity. For the prostheses, assessments were made of weight, shape, wearing time and frequency of cleaning.
  
  
  RESULTS
  Anophthalmic sockets had more severe conjunctival inflammation than their companion eyes (p = 0.0001). The difference in inflammation between the companion eye and the anophthalmic socket was associated with discharge volume (p = 0.01) and discharge viscosity (p = 0.007) with greater difference in inflammation being associated with higher levels of discharge volume and viscosity. A greater difference in inflammation was also associated with less surface deposition (p = 0.009). No evidence of associations was found between difference in conjunctival inflammation and the other variables.
  
  
  CONCLUSIONS
  Recently developed grading scales for measuring inflammation in anophthalmic sockets and deposits on prosthetic eyes were used for the first time in this study. It is recommended that in clinical practice, inflammation grades for both socket and companion eye conjunctivae be compared, when determining if prosthesis-induced inflammation is present. The finding that more discharge was associated with more conjunctival inflammation is logical but the finding that less inflammation was associated with more deposits is counter-intuitive to those familiar with the contact lens literature. The apparently benign nature of at least some deposits on the prostheses raises questions about the maintenance of prosthetic eyes. We conclude that the simple presence of deposits is unlikely to be linked with inflammation of the conjunctiva in wearers of prostheses, who like those in this study, cleaned their prostheses regularly but not frequently.
authors: Department of Optometry and Vision Science, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand.
authors: Keith Raymond
authors: KR
authors: Pine
authors: Brian
authors: B
authors: Sloan
authors: Joanna
authors: J
authors: Stewart
authors: Robert John
authors: RJ
authors: Jacobs
mesh_terms: D000853:Anophthalmos / Q000473:pathology / Q000601:surgery*; D003231:Conjunctivitis / Q000473:pathology; D005137:Eye, Artificial; D006801:Humans; D014783:Viscosity
keywords: anophthalmic socket; conjunctiva; deposits; inflammation; prosthetic eye