title: Free fatty acid receptor GPR120 and pathogenesis of obesity and type 2 diabetes mellitus.
abstract: G protein-coupled receptor 120 (GPR120) was initially identified as an orphan receptor through mining the human genome databases. In 2005, GPR120 was deorphanized and shown to be a receptor for long-chain free fatty acids. GPR120 regulates various physiological processes, including gut hormone secretion, islet function, food preference, osteoclastogenesis, anti-inflammation, adipogenesis, and appetite control. Recently, a human genetic study conducted in European populations identified a loss-of-function GPR120 mutation associated with obesity and insulin resistance. Therefore, GPR120, the sensing receptor for long-chain free fatty acids, represents a novel drug target for the treatment of obesity and diabetes.
authors: Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.
authors: Xiu-Lei
authors: XL
authors: Mo
authors: Hong-Kui
authors: HK
authors: Wei
authors: Jian
authors: J
authors: Peng
authors: Ya-Xiong
authors: YX
authors: Tao
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D009765:Obesity / Q000209:etiology* / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D005230:Fatty Acids, Nonesterified; D043562:Receptors, G-Protein-Coupled