title: Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: a collaborative study.
abstract: OBJECTIVE
  To determine if the associations among established risk factors and reduced kidney function vary by age.
  
  
  METHODS
  We pooled cross-sectional data from 14,788 nondiabetics aged 40 to 100 years in 4 studies: Cardiovascular Health Study, Health, Aging, and Body Composition Study, Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal and Vascular End-Stage Disease cohort.
  
  
  RESULTS
  Hypertension and low high-density lipoprotein (HDL) cholesterol were associated with reduced cystatin C-based estimated glomerular filtration rate (eGFR) across the age spectrum. In adjusted analyses, hypertension was associated with a 2.3 (95% confidence interval [CI], 0.1, 4.4), 5.1 (95% CI, 4.1, 6.1), and 6.9 (95% CI, 3.0, 10.4) mL/min/1.73 m(2) lower eGFR in participants 40 to 59, 60 to 79, and at least 80 years, respectively (P for interaction < .001). The association of low HDL cholesterol with reduced kidney function was also greater in the older age groups: 4.9 (95% CI, 3.5, 6.3), 7.1 (95% CI, 6.0, 8.3), 8.9 (95% CI, 5.4, 11.9) mL/min/1.73 m(2) (P for interaction < .001). Smoking and obesity were associated with reduced kidney function in participants under 80 years. All estimates of the potential population impact of the risk factors were modest.
  
  
  CONCLUSIONS
  Hypertension, obesity, smoking, and low HDL cholesterol are modestly associated with reduced kidney function in nondiabetics. The associations of hypertension and HDL cholesterol with reduced kidney function seem to be stronger in older adults.
authors: School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR, USA. Michelle.Odden@oregonstate.edu
authors: Michelle C
authors: MC
authors: Odden
authors: Ira B
authors: IB
authors: Tager
authors: Ron T
authors: RT
authors: Gansevoort
authors: Stephan J L
authors: SJ
authors: Bakker
authors: Linda F
authors: LF
authors: Fried
authors: Anne B
authors: AB
authors: Newman
authors: Ronit
authors: R
authors: Katz
authors: Suzanne
authors: S
authors: Satterfield
authors: Tamara B
authors: TB
authors: Harris
authors: Mark J
authors: MJ
authors: Sarnak
authors: David
authors: D
authors: Siscovick
authors: Michael G
authors: MG
authors: Shlipak
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015984:Causality; D008078:Cholesterol, LDL / Q000097:blood*; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology*; D007677:Kidney Function Tests; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
chemical_list: D008078:Cholesterol, LDL; D055316:Cystatin C