title: Adverse birth outcomes in the vicinity of industrial installations in Spain 2004-2008.
abstract: Industrial activity is one of the main sources of ambient pollution in developed countries. However, research analyzing its effect on birth outcomes is inconclusive. We analyzed the association between proximity of mother's municipality of residence to industries from 24 different activity groups and risk of very (VPTB) and moderate (MPTB) preterm birth, very (VLBW) and moderate (MLBW) low birth weight, and small for gestational age (SGA) in Spain, 2004-2008. An ecological study was defined, and a "near vs. far" analysis (3.5 km threshold) was carried out using Hierarchical Bayesian models implemented via Integrated Nested Laplace Approximation. VPTB risk was higher for mothers living near pharmaceutical companies. Proximity to galvanization and hazardous waste management industries increased the risk of MPTB. Risk of VLBW was higher for mothers residing near pharmaceutical and non-hazardous or animal waste management industries. For MLBW many associations were found, being notable the proximity to mining, biocides and animal waste management plants. The strongest association for SGA was found with proximity to management animal waste plants. These results highlight the importance of further research on the relationship between proximity to industrial sites and the occurrence of adverse birth outcomes especially for the case of pharmaceutical and animal waste management activities.
authors: National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain. acastello@isciii.es
authors: Adela
authors: A
authors: Castelló
authors: Isabel
authors: I
authors: Río
authors: Javier
authors: J
authors: García-Pérez
authors: Pablo
authors: P
authors: Fernández-Navarro
authors: Lance A
authors: LA
authors: Waller
authors: Julie A
authors: JA
authors: Clennon
authors: Francisco
authors: F
authors: Bolúmar
authors: Gonzalo
authors: G
authors: López-Abente
mesh_terms: D000328:Adult; D001499:Bayes Theorem; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006256:Hazardous Waste / Q000009:adverse effects; D006798:Housing; D006801:Humans; D007221:Industry; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008906:Mining; D011247:Pregnancy; D047928:Premature Birth; D012307:Risk Factors; D012959:Socioeconomic Factors; D013030:Spain; D055815:Young Adult
chemical_list: D006256:Hazardous Waste