title: Vinclozolin--no transgenerational inheritance of anti-androgenic effects after maternal exposure during organogenesis via the intraperitoneal route.
abstract: The goal of this study was to examine the potential transgenerational inheritance of anti-androgenic effects induced by Vinclozolin administered intraperitoneally to pregnant Wistar rats (Crl:WI[Han]). Dams were dosed with Vinclozolin at 0, 4 or 100mg/kg bw/d on gestation days 6-15. Male offspring of F1-F3 generations were bred with untreated females to yield F2-F4 offspring. No evident anti-androgenic effects were observed at 4mg/kg bw/d, but a case of hypospadias as well as delayed sexual maturation in F1 male offspring was observed as a sign of anti-androgenicity at 100mg/kg bw/d. However, F1-F3 males developed normally to sexual maturity and were able to mate and to generate healthy progeny. Sperm count, morphology and motility were not affected in F1-F4 generation male offspring. In conclusion, transgenerational inheritance of Vinclozolin's anti-androgenic effects was not evident in outbred Wistar rats.
authors: Experimental Toxicology and Ecotoxicology, BASF SE, 67056 Ludwigshafen, Germany.
authors: Steffen
authors: S
authors: Schneider
authors: Heike
authors: H
authors: Marxfeld
authors: Sibylle
authors: S
authors: Gröters
authors: Roland
authors: R
authors: Buesen
authors: Bennard
authors: B
authors: van Ravenzwaay
mesh_terms: D000726:Androgen Antagonists / Q000633:toxicity*; D000818:Animals; D005260:Female; D005837:Genitalia, Male / Q000187:drug effects / Q000196:embryology; D007021:Hypospadias / Q000139:chemically induced; D008297:Male; D008431:Maternal-Fetal Exchange; D038081:Organogenesis / Q000187:drug effects; D010080:Oxazoles / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D012741:Sexual Maturation / Q000187:drug effects; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects
chemical_list: D000726:Androgen Antagonists; D010080:Oxazoles; C025643:vinclozolin