title: Psychosomatic symptom profiles in patients with restless legs syndrome.
abstract: OBJECTIVE
  It has been reported that restless legs syndrome (RLS) might be associated with multiple psychosomatic symptoms. We aimed to identify which psychosomatic symptom is the most related in RLS patients compared to healthy controls. We also attempted to determine the relation between psychosomatic comorbidity and RLS severity regardless of sleep-related symptoms.
  
  
  METHODS
  One hundred two newly diagnosed patients with RLS and 37 healthy control subjects participated in the present study. The RLS patients were categorized as mild and severe based on the International RLS Study Group rating scale. Data on demographics were collected. All participants completed the Pittsburgh Sleep Quality Index, Athens Insomnia Scale, and Epworth Sleepiness Scale as sleep-related questionnaires. All participants completed the Symptom Checklist-90-Revision (SCL-90-R).
  
  
  RESULTS
  RLS patients were found to have pervasive comorbid psychosomatic symptoms. Somatization was found to be the most significant contributing factor (OR 1.145, 95 % CI 1.061-1.234, p < 0.001) for psychosomatic comorbidity in RLS. Severe RLS patients were found to have poorer sleep quality than mild RLS patients. Furthermore, severe RLS patients had higher scores for most psychosomatic symptom domains in SCL-90-R. Anxiety was found to be the most independent contributing factor for psychosomatic comorbidity according to RLS severity (OR 1.145, 95 % CI 1.043-1.257, p = 0.005).
  
  
  CONCLUSIONS
  Our study demonstrates that comorbid psychosomatic distress is considerable in patients with RLS. Furthermore, most psychosomatic comorbidity is increased with the RLS severity in association with poorer sleep quality.
authors: Department of Neurology, Korea University Medical Center, Korea University College of Medicine, #126-1 Anam-Dong 5Ga, Seongbuk-Gu, Seoul 136-705, South Korea.
authors: Jung Bin
authors: JB
authors: Kim
authors: Yong Seo
authors: YS
authors: Koo
authors: Mi-Yeon
authors: MY
authors: Eun
authors: Kun-Woo
authors: KW
authors: Park
authors: Ki-Young
authors: KY
authors: Jung
mesh_terms: D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D016022:Case-Control Studies; D057189:Checklist; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D010554:Personality Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D011594:Psychometrics / Q000706:statistics & numerical data; D011602:Psychophysiologic Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D012016:Reference Values; D012148:Restless Legs Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D012737:Sex Factors; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D011795:Surveys and Questionnaires