title: Maternal cerebral venous thrombosis, uncommon but serious disorder, pathologic predictors and contribution of prothrombotic abnormalities.
abstract: Cerebral venous thrombosis (CVT) is a rare complication during pregnancy or the puerperium. Our aim was to identify thrombotic risk profiles that predispose to maternal CVT.The study comprised 151 individuals. All participants had a thrombotic workup that included the following: genetic markers: factor V Leiden G1691A and G20210A prothrombin mutations, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms; protein assays: protein C, protein S and antithrombin; other tests: blood typing and screening for hyperhomocysteinemia. Maternal CVT has been associated with factor V Leiden, the prothrombin G20210A mutation, protein C deficiency and hyperhomocysteinemia. We also speculate that non-O blood groups and preeclampsia could be independent risk factors for CVT.
authors: Department of Hematology, Unit of Molecular Biology, Military Hospital, Tunis, Tunisia. gksarrah@yahoo.fr
authors: Sarra
authors: S
authors: Klai
authors: Najiba
authors: N
authors: Fekih-Mrissa
authors: Ridha
authors: R
authors: Mrissa
authors: Radhouen
authors: R
authors: Rachdi
authors: Nasredine
authors: N
authors: Gritli
mesh_terms: D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications / Q000235:genetics* / Q000473:pathology; D020767:Intracranial Thrombosis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000235:genetics* / Q000473:pathology; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors; D020246:Venous Thrombosis / Q000150:complications / Q000235:genetics* / Q000473:pathology
chemical_list: D015415:Biomarkers; D011486:Protein C; D017293:Protein S; C095381:factor V Leiden; D000990:Antithrombin III; D005165:Factor V; D011516:Prothrombin; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)