title: Health benefits of high-density lipoproteins in preventing cardiovascular diseases.
abstract: Plasma levels of high-density lipoprotein (HDL) are strongly and inversely correlated with atherosclerotic cardiovascular diseases. However, it is becoming clear that a functional HDL is a more desirable target than simply increasing HDL-cholesterol levels. The best known antiatherogenic function of HDL particles relates to their ability to promote reverse cholesterol transport from peripheral cells. However, HDL also possesses antioxidant, anti-inflammatory, and antithrombotic effects. This review focuses on the state of knowledge regarding assays of HDL heterogeneity and function and their relationship to cardiovascular diseases.
authors: Research Centre on Aging, Sherbrooke University Geriatric Institute, Sherbrooke, QC, Canada J1H 4C4. Hicham.berrougui@USherbrooke.ca
authors: Hicham
authors: H
authors: Berrougui
authors: Claudia N
authors: CN
authors: Momo
authors: Abdelouahed
authors: A
authors: Khalil
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000818:Animals; D000924:Anticholesteremic Agents / Q000378:metabolism* / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism; D016632:Apolipoprotein A-I / Q000235:genetics / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000235:genetics / Q000378:metabolism; D001692:Biological Transport; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D008075:Lipoproteins, HDL / Q000097:blood* / Q000145:classification / Q000378:metabolism; D051379:Mice; D010084:Oxidation-Reduction
chemical_list: C505693:APOA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D000924:Anticholesteremic Agents; D000975:Antioxidants; D016632:Apolipoprotein A-I; D008075:Lipoproteins, HDL; D002784:Cholesterol; D043303:Aryldialkylphosphatase; C560867:PON1 protein, mouse