title: Expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma.
abstract: OBJECTIVE
  Proteases of the disintegrin and metalloproteinase family (also known as ADAM proteins) are involved in various physiological and pathological processes. This study assessed the expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma.
  
  
  METHODS
  The study evaluated cholesteatoma specimens from 19 patients, and external ear canal skin samples from 7 of the same patients (as controls), for the expression of disintegrin and metalloproteinase family proteins 10, 12 and 17, using immunohistochemical methods.
  
  
  RESULTS
  The study observed over-expression of proteins 10 and 17 in blood vessels, and over-expression of proteins 12 and 17 in cholesteatoma stroma. Immunostaining scores for proteins 10, 12 and 17 in epithelial and inflammatory cells from cholesteatoma specimens versus control specimens showed no statistically significant differences.
  
  
  CONCLUSIONS
  Over-expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma may be related to cholesteatoma pathogenesis. These proteins deserve further study as they may represent potential targets for cholesteatoma treatment.
authors: Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors: S
authors: S
authors: Erbek
authors: Department of Pathology, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors: H
authors: H
authors: Erinanc
authors: Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors: E
authors: E
authors: Hizal
authors: Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors: L N
authors: LN
authors: Ozluoglu
mesh_terms: D018424:Cholesteatoma, Middle Ear / Q000378:metabolism* / Q000473:pathology; D019483:Disintegrins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D053506:Matrix Metalloproteinase 10 / Q000378:metabolism*; D053508:Matrix Metalloproteinase 12 / Q000378:metabolism*; D053504:Matrix Metalloproteinases, Membrane-Associated / Q000378:metabolism*
chemical_list: D019483:Disintegrins; C402225:MMP17 protein, human; D053504:Matrix Metalloproteinases, Membrane-Associated; C511770:MMP10 protein, human; D053506:Matrix Metalloproteinase 10; D053508:Matrix Metalloproteinase 12