title: Prevalence of CXCR4-tropic viruses in clustered transmission chains at the time of primary HIV-1 infection.
abstract: During 2003-2010, 555 strains isolated from sexually-infected patients at the time of primary HIV-1 infection (PHI) were characterized. Tree topology revealed that 11.7% of PHIs segregated into transmission clusters. CXCR4-usage was identified in 27 strains (4.9%) and was significantly associated with subtype B (p 0.003) and low CD4 cell count (p 0.01). In clustered and unique PHIs, the prevalence of CXCR4-tropic strains was 1.5% and 5.3%, respectively (p 0.35). Our results are in line with the hypothesis of a mucosal bottleneck contributing to the high prevalence of CCR5 variants during PHI.
authors: EA 3620, Université Paris-Descartes, Sorbonne Paris Cité, Paris, France. pierre.frange@nck.aphp.fr
authors: P
authors: P
authors: Frange
authors: L
authors: L
authors: Meyer
authors: J
authors: J
authors: Ghosn
authors: C
authors: C
authors: Deveau
authors: C
authors: C
authors: Goujard
authors: C
authors: C
authors: Duvivier
authors: R
authors: R
authors: Tubiana
authors: C
authors: C
authors: Rouzioux
authors: M-L
authors: ML
authors: Chaix
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016000:Cluster Analysis; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D019718:Receptors, CXCR4 / Q000378:metabolism*; D015728:Receptors, HIV / Q000378:metabolism*; D056189:Viral Tropism; D055815:Young Adult
chemical_list: C527276:CXCR4 protein, human; D019718:Receptors, CXCR4; D015728:Receptors, HIV