title: Translational developmental studies of stress on brain and behavior: implications for adolescent mental health and illness?
abstract: Adolescence is the transition from childhood to adulthood, with onset marked by puberty and the offset by relative independence from parents. Across species, it is a time of incredible change that carries increased risks and rewards. The ability of the individual to respond adequately to the mental, physical and emotional stresses of life during this time is a function of both their early environment and their present state. In this article, we focus on the effects that acute threat and chronic stress have on the brain and behavior in humans and rodents. First, we highlight developmental changes in frontolimbic function as healthy individuals transition into and out of adolescence. Second, we examine genetic factors that may enhance susceptibility to stress in one individual over another using translation from genetic mouse models to human neuroimaging. Third, we examine how the timing and nature of stress varies in its impact on brain and behavior. These findings are discussed in the context of implications for adolescent mental health and illness.
authors: Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, 1300 York Avenue, P.O. Box 140, New York, NY 10065, USA. mhm2002@med.cornell.edu
authors: M
authors: M
authors: Malter Cohen
authors: N
authors: N
authors: Tottenham
authors: B J
authors: BJ
authors: Casey
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000502:physiology* / Q000523:psychology; D000818:Animals; D001921:Brain / Q000502:physiology*; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000378:metabolism* / Q000523:psychology; D008603:Mental Health; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism* / Q000523:psychology; D057170:Translational Research, Biomedical / Q000379:methods*
keywords: BDNF; BDNFmet; MRI; Met; P; PI; SCR; Val; Val66met; adolescence; anxiety; brain-derived neurotrophic factor; emotion regulation; fMRI; fear; functional magnetic resonance imaging; magnetic resonance imaging; methionine; methionine in codon 66 of the BDNF protein; postnatal day; previously institutionalized; skin conductance response; stress; valine; valine-to-methionine substitution at codon 66; ventromedial prefrontal cortex; vmPFC