title: The IGF-1 receptor and regulation of nitric oxide bioavailability and insulin signalling in the endothelium.
abstract: The insulin-like growth factor-1 receptor (IGF-1R), like the insulin receptor (IR), plays a significant role in determining bioavailability of the critical signalling molecule nitric oxide (NO) and hence, modulates endothelial cell function, particularly in response to stimulation with insulin. In particular, the ability of the IGF-1R to form hybrid receptors with the IR appears to be highly significant in determining the sensitivity of the endothelial cell to insulin. This review will examine the structure of the IGF-1R and how this, with particular reference to the ability of the IGF-1R and the IR to form hybrid receptors, may have an effect both on endothelial cell function and the development of cardiovascular disease.
authors: Department of Diabetes and Cardiovascular Research, LIGHT Laboratories, University of Leeds, Clarendon Way, Leeds, LS2 9NL, UK. kategatenby@gmail.com
authors: V Kate
authors: VK
authors: Gatenby
authors: Helen
authors: H
authors: Imrie
authors: Mark
authors: M
authors: Kearney
mesh_terms: D000818:Animals; D001682:Biological Availability; D042783:Endothelial Cells / Q000378:metabolism / Q000502:physiology; D004727:Endothelium / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007328:Insulin; D009569:Nitric Oxide; D017526:Receptor, IGF Type 1