title: Intraorbital metastasis from solitary fibrous tumor.
abstract: Solitary fibrous tumor (SFT) is a rare spindle cell tumor of mesenchymal origin that usually arises from pleura or pericardium but can also arise from many extraserosal sites. Although more than 50 cases of primary SFT of the orbit have been reported, there are no reports to date of a malignant nonophthalmic SFT metastasizing in the orbital soft tissues (although sphenoid wing bony involvement has been reported). The authors report here the first case of a patient with intraorbital metastasis of a CD34-positive malignant SFT. The patient was a 57-year-old man with a history of malignant pleural SFT and a prior kidney metastasis. He presented with the rapid appearance of proptosis and massive conjunctival chemosis preventing eyelid closure, and he was found to have a well-circumscribed metastasis to his lateral rectus muscle. Surgical excision cured his ocular symptoms, although he died 3 months later from brain and widespread metastases.
authors: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.
authors: Mrinali M
authors: MM
authors: Patel
authors: Frederick A
authors: FA
authors: Jakobiec
authors: Fouad R
authors: FR
authors: Zakka
authors: Rose
authors: R
authors: Du
authors: Donald J
authors: DJ
authors: Annino
authors: Sheila
authors: S
authors: Borboli-Gerogiannis
authors: Anthony B
authors: AB
authors: Daniels
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D010997:Pleural Neoplasms / Q000473:pathology* / Q000628:therapy; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D054363:Solitary Fibrous Tumor, Pleural / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy
chemical_list: D018952:Antigens, CD34; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D019253:Proto-Oncogene Proteins c-bcl-2