title: [To evaluate the role of OLT on splenomegaly of portal hypertension by the radiological changes of splenic morphology and collaterals].
abstract: OBJECTIVE
  To explore the effect of orthotopic liver transplantation (OLT) on portal hypertension by observing the radiological changes of splenic volume and collaterals before and after OLT.
  
  
  METHODS
  In our hospital 56 patients performing OLT due to cirrhosis, portal hypertension and splenomegaly were classified into five groups according to their following-up time: A (≤3 months), B (>3-6 months), C (>6-12 months), D (>12-24 months), and E (>24 months). Twenty health people were chose as control group (F). The splenic width, thickness, length, volume, diameter of portal and splenic vein and collaterals were measured and observed in every patient of six groups before and after OLT respectively.
  
  
  RESULTS
  After OLT, the splenic volume decreased by 25.4%, 27.8%, 21.9%, 25.2%, 27.7% in five groups respectively, which was still larger than the normal group (P<0.05). Gastroesophageal varices in 31 cases (81.6%, 31/36) became normal after OLT. The opened umbilical vein disappeared and the retroperitoneal varices persisted in five cases after OLT.
  
  
  CONCLUSIONS
  Splenomegaly and opened collaterals can be relieved by OLT effectively. The splenic volume didn't change obviously until it decreased by 25% in the three months after OLT. Gastroesophageal varices can be removed in most of patients after OLT. The splenomegaly could last paralled with the splenic vein and retroperitoneal varices after OLT. After OLT, correct disposal of splenic and collateral changes could improve the success rate and the long-term treatment effect of OLT.
authors: Department of Medical Radiology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China.
authors: Ying-ying
authors: YY
authors: Liang
authors: Jin
authors: J
authors: Wang
authors: Hong
authors: H
authors: Shan
authors: Rong-hua
authors: RH
authors: Yan
authors: Bing
authors: B
authors: Hu
authors: Zai-bo
authors: ZB
authors: Jiang
authors: Bing-jun
authors: BJ
authors: He
authors: Jing-jing
authors: JJ
authors: Liu
authors: Ling-lan
authors: LL
authors: Ren
authors: Shuo
authors: S
authors: Shao
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003097:Collateral Circulation; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000473:pathology* / Q000601:surgery; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000473:pathology*; D013163:Splenomegaly / Q000601:surgery; D016896:Treatment Outcome