title: Fetal skin possesses the ability to regenerate completely: complete regeneration       of skin.
abstract: Until a certain developmental stage, cutaneous wounds in mammalian fetuses heal       rapidly without scars with complete regeneration of the skin. In the process of fetal wound       healing, inflammatory responses, granulation proliferation, and scar formation that are       observed in adults are not seen. Numerous studies have reported the causes of fetal scarless       cutaneous regeneration, including reduced expression of TGF-β1 and higher levels of hyaluronan       in the extracellular matrix, from the viewpoints of molecular biology and cellular biology,       but the mechanisms are not completely understood. Although a variety of substances that       inhibit scar formation have been investigated, currently it is almost impossible for adult       cutaneous wounds to heal completely without scars. Except for a few animal species, perfect       regeneration after wounding can occur only during the gestation period. By strictly comparing       the stages before and after the transition from the regeneration of skin to scarring, it will       be possible to investigate the mechanisms of cutaneous regeneration.
authors: Department of Plastic and Reconstructive Surgery, School of Medicine, Keio University, Tokyo, Japan. kkishi@sc.itc.keio.ac.jp
authors: Kazuo
authors: K
authors: Kishi
authors: Keisuke
authors: K
authors: Okabe
authors: Ruka
authors: R
authors: Shimizu
authors: Yoshiaki
authors: Y
authors: Kubota
mesh_terms: D000328:Adult; D000818:Animals; D002921:Cicatrix / Q000378:metabolism* / Q000503:physiopathology; D004622:Embryo, Mammalian; D005109:Extracellular Matrix / Q000502:physiology*; D005333:Fetus; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis; D051379:Mice; D062326:Re-Epithelialization / Q000502:physiology*; D012867:Skin / Q000166:cytology / Q000254:growth & development / Q000293:injuries* / Q000378:metabolism; D017695:Soft Tissue Injuries / Q000196:embryology / Q000378:metabolism* / Q000503:physiopathology; D053773:Transforming Growth Factor beta1 / Q000096:biosynthesis
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D053773:Transforming Growth Factor beta1