title: Bis-vinyl selenides obtained via iron(III) catalyzed addition of PhSeSePh to alkynes: synthesis and antinociceptive activity.
abstract: In the present study the synthesis and antinociceptive activity of bis-vinyl selenides, prepared via FeCl(3) promoted reaction addition of diorganyl dichalcogenides to alkynes, is described. The pharmacological results demonstrated that bis-vinyl selenides 3a, 3d, 3h and 3t elicited antinociceptive effect in the mouse formalin test. The antinociceptive effects of bis-vinyl selenides are not sensitive to electronic effects of the substituents on the aromatic ring directly bonded to the selenium atom. Bis-vinyl selenides 3h and 3t were the most promising molecules for pharmacological purposes since these bis-vinyl selenides were effective in both phases of the formalin test and against edema. A single dose of bis-vinyl selenides 3a, 3d, 3h and 3t did not cause acute toxicity in mice.
authors: Laboratório de Síntese, Reatividade, Avaliação Farmacológica e Toxicológica de Organocalcogênios, CCNE, UFSM, Santa Maria, Rio Grande do Sul 97105-900, Brazil.
authors: Glaubia
authors: G
authors: Sartori
authors: José S S
authors: JS
authors: Neto
authors: Ana Paula
authors: AP
authors: Pesarico
authors: Davi F
authors: DF
authors: Back
authors: Cristina W
authors: CW
authors: Nogueira
authors: Gilson
authors: G
authors: Zeni
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000700:Analgesics / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005290:Ferric Compounds / Q000737:chemistry*; D005557:Formaldehyde; D008297:Male; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D059226:Nociceptive Pain / Q000139:chemically induced / Q000188:drug therapy; D016566:Organoselenium Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000480:Alkynes; D000700:Analgesics; D002712:Chlorides; D005290:Ferric Compounds; D016566:Organoselenium Compounds; D005557:Formaldehyde; C024555:ferric chloride