title: Visualization of experimental glioma C6 by MRI with magnetic nanoparticles conjugated with monoclonal antibodies to vascular endothelial growth factor.
abstract: We developed a method for obtaining iron oxide nanoparticles and their conjugation with monoclonal antibodies to vascular endothelial growth factor. The resultant vector nanoparticles were low-toxic and the antibodies retained their immunochemical activity after conjugation. The study was carried out on rats with intracranial glioma C6 on day 14 after its implantation. The intravenously injected nanoparticles visualized the brain tumor in contrast to nanoparticles conjugated with nonspecific immunoglobulins that did not accumulate in the tumor.
authors: Department of Medical Nanobiotechnologies, N. I. Pirogov Russian National Research Medical University, Moscow, Russia. abakumov1988@gmail.com
authors: M A
authors: MA
authors: Abakumov
authors: S A
authors: SA
authors: Shein
authors: H
authors: H
authors: Vishvasrao
authors: N V
authors: NV
authors: Nukolova
authors: M
authors: M
authors: Sokol'ski-Papkov
authors: T O
authors: TO
authors: Sandalova
authors: I L
authors: IL
authors: Gubskii
authors: N F
authors: NF
authors: Grinenko
authors: A V
authors: AV
authors: Kabanov
authors: V P
authors: VP
authors: Chekhonin
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry* / Q000276:immunology*; D003287:Contrast Media / Q000737:chemistry; D005260:Female; D005910:Glioma / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D051381:Rats; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D003287:Contrast Media; D042461:Vascular Endothelial Growth Factor A