title: High HIF-1α expression genotypes in oral lichen planus.
abstract: OBJECTIVE
  The aim of this study is to assess whether C1772T and G1790A hypoxia-inducible factor-1 (HIF-1)α polymorphisms are associated with risk of oral lichen planus (OLP).
  
  
  METHODS
  Restriction fragment length polymorphism analysis was used to investigate HIF-1α C1779T and G1790A polymorphisms in 32 OLP and 88 individuals without OLP.
  
  
  RESULTS
  The frequency of the CC, TT, GA, and AA genotypes was higher in patients with OLP. Notably, individuals carrying the C and A, and T and A haplotypes showed a significant association OLP risk.
  
  
  CONCLUSIONS
  Our study demonstrated that the C1772T and G1790A polymorphisms of HIF-1α gene increased the risk of OLP. C1772T and G1790A polymorphisms of HIF-1α gene had differing patterns of allelic imbalance in the normal samples and subsequent chronic lesions. Further studies are necessary to elucidate the HIF-1α pathway in OLP, which would facilitate the development of novel therapeutic strategies for the prevention and treatment of OLP.
  
  
  CONCLUSIONS
  These results, in conjunction with previous studies, suggest that HIF-1α may play important roles in the chronicity of oral mucosa lesions of OLP patients. Taken together, we suggest that HIF-1α polymorphisms enhance its target genes, thereby altering the microenvironment and supporting sequential release of inflammatory mediators or cellular events in OLP. It appears unlikely that inhibition of a single proinflammatory mediator will prove useful in clinical practice, but several ways to reprogram mediators engaged in a wide array of roles simultaneously are encouraging.
authors: Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil.
authors: Carlos Alberto
authors: CA
authors: de Carvalho Fraga
authors: Lucas Rodrigues
authors: LR
authors: Alves
authors: Luciano
authors: L
authors: Marques-Silva
authors: Adriana Alkmim
authors: AA
authors: de Sousa
authors: Antonio Sérgio Barcala
authors: AS
authors: Jorge
authors: Sabrina Ferreira
authors: SF
authors: de Jesus
authors: Daniel Nogueira
authors: DN
authors: Vilela
authors: Ugo Borges
authors: UB
authors: Pinheiro
authors: Kimberly Marie
authors: KM
authors: Jones
authors: Alfredo Maurício Batista
authors: AM
authors: de Paula
authors: André Luiz Sena
authors: AL
authors: Guimarães
mesh_terms: D005838:Genotype; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D017676:Lichen Planus, Oral / Q000235:genetics*
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit