title: Preliminary investigation into the ventilatory effects of midazolam in isoflurane-anaesthetised goats.
abstract: The ventilatory effects of intravenous midazolam (MDZ) were evaluated in isoflurane- anaesthetised goats. Eight female goats aged 2-3 years were fasted from food and water  for 12 h. Anaesthesia was then induced using a face mask with isoflurane in oxygen, whilst  the trachea was intubated with a cuffed tracheal tube and anaesthesia maintained with  isoflurane at 1.5% end-tidal concentration. Ventilation was spontaneous. The goats were  treated with either a saline placebo (PLC) or MDZ intravenously at 0.2 mg/kg. Analysis of  variance for repeated measures was used for the analysis of data. Significance was taken at  the 0.05 level. Differences between treatments were not statistically significant (p &gt; 0.05) for tidal volume, ventilation rate, tidal volume/kg (VT/kg) and end-tidal carbon dioxide partial pressure. Within treatments, VT and VT/kg differed 5 min after MDZ administration; this was statistically significant (p &lt; 0.05). The occurrence of apnoea in the MDZ-treated goats was statistically significant (p = 0.04) compared with the PLC treated goats. Intravenous MDZ at 0.2 mg/kg administered to isoflurane-anaesthetised goats may result in transient apnoea and a mild decrease in VT and VT/kg.
authors: Department of Companion Animal Clinical Studies, University of Pretoria, South Africa. frik.stegmann@up.ac.za
authors: George F
authors: GF
authors: Stegmann
authors: Lynette
authors: L
authors: Bester
mesh_terms: D000769:Anesthesia, Inhalation / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D018592:Cross-Over Studies; D004359:Drug Therapy, Combination; D005260:Female; D006041:Goats / Q000502:physiology*; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D007530:Isoflurane; D008874:Midazolam