title: Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium.
abstract: BACKGROUND
  Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations.
  
  
  METHODS
  We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol.
  
  
  RESULTS
  Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations.
  
  
  CONCLUSIONS
  We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.
authors: Department of Population Health Research, Alberta Health Services-Cancer Care, AB, Canada. LKelemen@post.harvard.edu
authors: Linda E
authors: LE
authors: Kelemen
authors: Elisa V
authors: EV
authors: Bandera
authors: Kathryn L
authors: KL
authors: Terry
authors: Mary Anne
authors: MA
authors: Rossing
authors: Louise A
authors: LA
authors: Brinton
authors: Jennifer A
authors: JA
authors: Doherty
authors: Roberta B
authors: RB
authors: Ness
authors: Susanne Krüger
authors: SK
authors: Kjaer
authors: Jenny
authors: J
authors: Chang-Claude
authors: Martin
authors: M
authors: Köbel
authors: Galina
authors: G
authors: Lurie
authors: Pamela J
authors: PJ
authors: Thompson
authors: Michael E
authors: ME
authors: Carney
authors: Kirsten
authors: K
authors: Moysich
authors: Robert
authors: R
authors: Edwards
authors: Clare
authors: C
authors: Bunker
authors: Allan
authors: A
authors: Jensen
authors: Estrid
authors: E
authors: Høgdall
authors: Daniel W
authors: DW
authors: Cramer
authors: Allison F
authors: AF
authors: Vitonis
authors: Sara H
authors: SH
authors: Olson
authors: Melony
authors: M
authors: King
authors: Urmila
authors: U
authors: Chandran
authors: Jolanta
authors: J
authors: Lissowska
authors: Montserrat
authors: M
authors: Garcia-Closas
authors: Hannah
authors: H
authors: Yang
authors: Penelope M
authors: PM
authors: Webb
authors: Joellen M
authors: JM
authors: Schildkraut
authors: Marc T
authors: MT
authors: Goodman
authors: Harvey A
authors: HA
authors: Risch
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology*; D000434:Alcoholic Beverages / Q000009:adverse effects; D001315:Australia / Q000453:epidemiology; D002170:Canada / Q000453:epidemiology; D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology; D016022:Case-Control Studies; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D015999:Multivariate Analysis; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000473:pathology; D018570:Risk Assessment; D012307:Risk Factors; D014481:United States / Q000453:epidemiology