title: Spindle cell rhabdomyosarcoma of the prostate.
abstract: The spindle cell rhabdomyosarcoma is a rare variant of the embryonal rhabdomyosarcoma, mostly occurring in childhood. Only a few cases are described in adults. To date, no case of the spindle cell subtype of the prostatic embryonal rhabdomyosarcoma has been published. We report on a 23-year-old man, initially presenting with obstructive micturition problems, perineal pain and night sweat. After diagnosis by transrectal biopsy of the prostate, radiochemotherapy within the CWS 2002 P study was applied: nine cycles of vincristine, doxorubicin, actinomycin D, ifosfamide, and fractionated radiotherapy of the tumor and suspect lymph nodes (final dose 50.4 Gy). The tumor initially shrank, but an early local recurrence arose. Second-line chemotherapy was applied, followed by a salvage radical cytoprostatectomy. The patient died of disseminated disease 14 months after diagnosis.
authors: Department of Urology, University of Bonn, Bonn, Germany.
authors: Stefan
authors: S
authors: Latz
authors: Jörg
authors: J
authors: Ellinger
authors: Diane
authors: D
authors: Goltz
authors: Christian
authors: C
authors: Marx
authors: Ivo
authors: I
authors: Leuschner
authors: Stefan C
authors: SC
authors: Müller
authors: Guido
authors: G
authors: Fechner
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000473:pathology*; D012509:Sarcoma / Q000188:drug therapy / Q000473:pathology*; D014750:Vincristine / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D004317:Doxorubicin; D007069:Ifosfamide
keywords: prostate; radiochemotherapy; rhabdomyosarcoma; surgery