title: Infection trials in mice suggest that Macrorhabdus ornithogaster is not capable of growth in mammals.
abstract: The objective of this study was to determine if Macrorhabdus ornithogaster, a yeast recovered from the junction of the proventriculus and ventriculus of the stomach of parrots and other birds, can infect mice. Fifteen healthy ARC (S) female mice (age 10 weeks) were incoculated with M. ornithogaster by gavage at (two different dosage rates [n = 5]) or intraperitoneal injection (n = 5) (one dosage rate). They were euthanized 5 days later and examined for gross and microscopic evidence of infection. Macrorhabdus ornithogaster was not found to colonize the stomach, peritoneum, or viscera of the challeneged mice. The results of this study show that M. ornithogaster is not able to infect mice by the oral and intraperitoneal routes of administration and suggest that infection in mammals is unlikely to occur.
authors: Bacterial and Parasitic Disease Research Division, National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki, Japan.
authors: Yasuko
authors: Y
authors: Hanafusa
authors: Enrica
authors: E
authors: Costa
authors: David N
authors: DN
authors: Phalen
mesh_terms: D000825:Animal Structures / Q000382:microbiology; D000818:Animals; D001717:Birds / Q000382:microbiology; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D004718:Saccharomycetales / Q000254:growth & development* / Q000302:isolation & purification / Q000472:pathogenicity*