title: Hybrid gold-gadolinium nanoclusters for tumor-targeted NIRF/CT/MRI triple-modal imaging in vivo.
abstract: Multimodal imaging is highly desirable for accurate diagnosis because it can provide complementary information from each imaging modality. In this study, we prepared hybrid gold-gadolinium nanoclusters (NCs), which are ultrasmall, stable, biocompatible, and suitable for triple-modal NIRF/CT/MRI imaging. Upon intravenously injected, the hybrid NCs are effectively accumulated in tumor tissues and quickly clear by renal excretion, indicating their capacity of tumor targeting and low body residues. Notably, the ultrasmall hybrid NCs would penetrate into the solid tumor for capturing its heterostructure and do not induce potential toxicity in vivo. Hence, the well-defined hybrid gold-gadolinium NCs provide a versatile nanoprobe for cancer targeted imaging and diagnosis in vivo.
authors: Guangdong Key Laboratory of Nanomedicine, Shenzhen Key Laboratory of Cancer Nanotechnology, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors: De-Hong
authors: DH
authors: Hu
authors: Zong-Hai
authors: ZH
authors: Sheng
authors: Peng-Fei
authors: PF
authors: Zhang
authors: Da-Zhi
authors: DZ
authors: Yang
authors: Shu-Hui
authors: SH
authors: Liu
authors: Ping
authors: P
authors: Gong
authors: Du-Yang
authors: DY
authors: Gao
authors: Sheng-Tao
authors: ST
authors: Fang
authors: Yi-Fan
authors: YF
authors: Ma
authors: Lin-Tao
authors: LT
authors: Cai
mesh_terms: D045744:Cell Line, Tumor; D003287:Contrast Media / Q000138:chemical synthesis; D005682:Gadolinium / Q000737:chemistry*; D006046:Gold; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008422:Materials Testing; D008856:Microscopy, Fluorescence / Q000379:methods*; D049329:Nanostructures; D009374:Neoplasms, Experimental / Q000175:diagnosis*; D010316:Particle Size; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D006046:Gold; D005682:Gadolinium