title: Synthesis, anticandidal activity and cytotoxicity of some tetrazole derivatives.
abstract: In this study, 14 different 2-[(1-methyl-1H-tetrazole-5-yl)thio]-1-(phenyl)ethanone derivatives (1-14) were synthesized. The structures of the obtained compounds were elucidated using IR, (1)H-NMR, (13)C-NMR and FAB(+)-MS spectral data and elemental analyses results. The compounds were screened for their anticandidal activity using the microbroth dilution method and for their cytotoxic effects using the MTT assay against NIH/3T3 cells. Some of the compounds were found to be potent anticandidal agents with weak cytotoxicities.
authors: Department of Pharmaceutical Chemistry, Graduate School of Health Sciences, Anadolu University , Eskisehir , Turkey .
authors: Zafer Asim
authors: ZA
authors: Kaplancikli
authors: Leyla
authors: L
authors: Yurttaş
authors: Ahmet
authors: A
authors: Özdemir
authors: Gülhan
authors: G
authors: Turan-Zitouni
authors: Gökalp
authors: G
authors: Işcan
authors: Gülşen
authors: G
authors: Akalın
authors: Usama
authors: U
authors: Abu Mohsen
mesh_terms: D000818:Animals; D002175:Candida / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D041681:NIH 3T3 Cells; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D013777:Tetrazoles