title: Synthesis and evaluation of 4,5-dihydro-5-methylisoxazolin-5-carboxamide derivatives as VLA-4 antagonists.
abstract: A novel set of compounds containing a 4,5-dihydro-5-methylisoxazoline have been successfully designed as VLA-4 receptor antagonists. Compound (14p) had a high receptor binding affinity of 4 nM and also found to be metabolically stable in vitro.
authors: Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratories, Plot 20, Sector 18, Gurgaon 122015, Haryana, India. ajay_soni_78@yahoo.com
authors: Ajay
authors: A
authors: Soni
authors: Abdul
authors: A
authors: Rehman
authors: Keshav
authors: K
authors: Naik
authors: Sunanda
authors: S
authors: Dastidar
authors: M S
authors: MS
authors: Alam
authors: Abhijit
authors: A
authors: Ray
authors: Tridib
authors: T
authors: Chaira
authors: Vanya
authors: V
authors: Shah
authors: Venkata P
authors: VP
authors: Palle
authors: Ian A
authors: IA
authors: Cliffe
authors: Viswajanani J
authors: VJ
authors: Sattigeri
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004355:Drug Stability; D006801:Humans; D039041:Integrin alpha4beta1 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011485:Protein Binding; D013329:Structure-Activity Relationship; D020298:U937 Cells
chemical_list: D000577:Amides; D039041:Integrin alpha4beta1; D007555:Isoxazoles