title: ARE-inducing phenol antioxidant TC-13 improves survival of Drosophila melanogaster in oxidative stress.
abstract: The effects of hydrophilic synthetic antioxidant TC-13 sodium (3'-(3'-tert-butyl-4'-hydroxyphenyl)propylthiosulfonate on survival of various strains of Drosophila melanogaster were studied under conditions of oxidative stress induced with H(2)O(2)and paraquat. In a concentration of 1%, TC-13 significantly improved survival of Canton S males treated with H(2)O(2)and in a concentration of 0.2% it improved survival of H(2)O(2)-stressed Oregon R females. The protective effect of the antioxidant under conditions of paraquat-induced stress was observed in Canton S females and Oregon R flies of both genders. Addition of T-13 to diets led to prolongation of the maximum lifespan of insects in the majority of the experiment variants. A relationship between the protective effects of TC-13 and the genotype, gender, and environmental conditions was detected.
authors: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Russia. lemen@soramn.ru
authors: E B
authors: EB
authors: Menshchikova
authors: N Ya
authors: NY
authors: Wisman
authors: N K
authors: NK
authors: Zenkov
authors: V O
authors: VO
authors: Tkachev
authors: N V
authors: NV
authors: Kandalintseva
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004331:Drosophila melanogaster / Q000187:drug effects*; D005260:Female; D006020:Glycopeptides / Q000627:therapeutic use*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D006020:Glycopeptides; C035790:TC 13; D006861:Hydrogen Peroxide