title: Integration of troponin I phosphorylation with cardiac regulatory networks.
abstract: We focus here on the modulation of thin filament activity by cardiac troponin I phosphorylation as an integral and adaptive mechanism in cardiac homeostasis and as a mechanism vulnerable to maladaptive response to stress. We discuss a current concept of cardiac troponin I function in the A-band region of the sarcomere and potential signaling to cardiac troponin I in a network involving the ends of the thin filaments at the Z-disk and the M-band regions. The cardiac sarcomere represents a remarkable set of interacting proteins that functions not only as a molecular machine generating the heartbeat but also as a hub of signaling. We review how phosphorylation signaling to cardiac troponin I is integrated, with parallel signals controlling excitation-contraction coupling, hypertrophy, and metabolism.
authors: Department of Physiology and Biophysics and Center for Cardiovascular Research, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA. solarorj@uic.edu
authors: R John
authors: RJ
authors: Solaro
authors: Marcus
authors: M
authors: Henze
authors: Tomoyoshi
authors: T
authors: Kobayashi
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology / Q000502:physiology; D010766:Phosphorylation / Q000502:physiology; D019210:Troponin I / Q000378:metabolism* / Q000502:physiology
chemical_list: D019210:Troponin I