title: Application of FISH 7q in MDS patients without monosomy 7 or 7q deletion by conventional G-banding cytogenetics: does -7/7q- detection by FISH have prognostic value?
abstract: Chromosomal abnormalities are detected in 40-60% of patients with de novo myelodysplastic syndromes (MDS). This study used the FISH technique in 773 patients with de novo MDS without evidence of monosomy 7 (-7) or 7q deletion (7q-) by conventional G-banding cytogenetics (CC) to analyze their prognostic impact by FISH alone. FISH detected -7/7q- in 5.2% of patients. Presence of -7/7q- was associated with shorter overall survival than absence of such aberrations. Our results suggest that FISH 7q could be beneficial in patients with intermediate WHO morphologic risk stratification and no evidence of -7/7q- by CC.
authors: Institut de Recerca Contra la Leucèmia Josep Carreras, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
authors: Vera
authors: V
authors: Ademà
authors: Jesús María
authors: JM
authors: Hernández
authors: María
authors: M
authors: Abáigar
authors: Eva
authors: E
authors: Lumbreras
authors: Esperanza
authors: E
authors: Such
authors: Anna
authors: A
authors: Calull
authors: Esther
authors: E
authors: Dominguez
authors: Leonor
authors: L
authors: Arenillas
authors: Mar
authors: M
authors: Mallo
authors: José
authors: J
authors: Cervera
authors: Isabel
authors: I
authors: Marugán
authors: Mar
authors: M
authors: Tormo
authors: Francisca
authors: F
authors: García
authors: Teresa
authors: T
authors: González
authors: Elisa
authors: E
authors: Luño
authors: Carmen
authors: C
authors: Sanzo
authors: María Luisa
authors: ML
authors: Martín
authors: Manuela
authors: M
authors: Fernández
authors: Dolors
authors: D
authors: Costa
authors: Beatriz
authors: B
authors: Blázquez
authors: Beatriz
authors: B
authors: Barreña
authors: Fernando
authors: F
authors: Marco
authors: Ana
authors: A
authors: Batlle
authors: Ismael
authors: I
authors: Buño
authors: Carolina
authors: C
authors: Martínez-Laperche
authors: Víctor
authors: V
authors: Noriega
authors: Rosa
authors: R
authors: Collado
authors: David
authors: D
authors: Ivars
authors: Félix
authors: F
authors: Carbonell
authors: Isabel
authors: I
authors: Vallcorba
authors: Josefa
authors: J
authors: Melero
authors: Elena
authors: E
authors: Delgado
authors: María Teresa
authors: MT
authors: Vargas
authors: Javier
authors: J
authors: Grau
authors: Marta
authors: M
authors: Salido
authors: Blanca
authors: B
authors: Espinet
authors: Carme
authors: C
authors: Melero
authors: Lourdes
authors: L
authors: Florensa
authors: Carmen
authors: C
authors: Pedro
authors: Francesc
authors: F
authors: Solé
mesh_terms: D002871:Chromosome Banding; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D011379:Prognosis