title: Choroidal thickness in fellow eyes of patients with acute primary angle-closure measured by enhanced depth imaging spectral-domain optical coherence tomography.
abstract: OBJECTIVE
  We evaluated choroidal thickness in the fellow eyes of patients with acute primary angle-closure (APAC) and compared findings to those of normal controls.
  
  
  METHODS
  The study group comprised 44 fellow eyes defined as primary angle-closure suspect (PACS) of 44 subjects who had experienced APAC and 43 eyes of 43 healthy volunteers. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the peripapillary and macular choroidal thickness of the PACS eyes and the control eyes were measured and compared at each location or segment. Pearson correlation analysis and a multivariable regression model were used to evaluate the relationships between choroidal thickness and related factors.
  
  
  RESULTS
  At all the macular locations, the choroidal thickness was thickest at the subfovea. The PACS eyes had a thicker choroid than the control eyes at all macular locations (all P < 0.05), and it still was significantly thicker after controlling for age, axial length, and sex, except at 3 mm superior from the fovea (P = 0.124). Multivariable linear regression analysis showed that the subfoveal choroidal thickness was significantly thicker in association with the PACS diagnosis, and thinner in association with older subjects and longer axial length eyes. There were no statistically significant differences in the choroidal thickness between the groups at any peripapillary location or segment (P > 0.05).
  
  
  CONCLUSIONS
  PACS eyes that had a fellow eye experience of APAC had a thicker macular choroid than the control eyes. The potential role of a thicker choroid as a risk factor for APAC must be investigated further.
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors: Minwen
authors: M
authors: Zhou
authors: Wei
authors: W
authors: Wang
authors: Xiaoyan
authors: X
authors: Ding
authors: Wenbin
authors: W
authors: Huang
authors: Shida
authors: S
authors: Chen
authors: Alan M
authors: AM
authors: Laties
authors: Xiulan
authors: X
authors: Zhang
mesh_terms: D000208:Acute Disease; D058452:Axial Length, Eye / Q000473:pathology*; D002829:Choroid / Q000473:pathology*; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007089:Image Enhancement; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity