title: Bioactive carboxylic acids from Lysimachia clethroides.
abstract: Six new carboxylic acids (1-6), together with 11 known ones (7-17), were isolated from the aerial parts of Lysimachia clethroides. Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. Five new carboxylic acids (1 and 3-6) were evaluated for their in vitro inhibitory activity against aldose reductase.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors: Dong
authors: D
authors: Liang
authors: Zhi-You
authors: ZY
authors: Hao
authors: Yan-Fei
authors: YF
authors: Liu
authors: Huan
authors: H
authors: Luo
authors: Yan
authors: Y
authors: Wang
authors: Chun-Lei
authors: CL
authors: Zhang
authors: Qing-Jian
authors: QJ
authors: Zhang
authors: Ruo-Yun
authors: RY
authors: Chen
authors: De-Quan
authors: DQ
authors: Yu
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029623:Primulaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D002264:Carboxylic Acids; D004365:Drugs, Chinese Herbal; D000449:Aldehyde Reductase