title: Frontiers and approaches to chemical synthesis of oligodeoxyribonucleotides.
abstract: The advantages and disadvantages of existing approaches to the synthesis of oligodeoxyribonucleotides (ODN) are discussed focusing on large-scale methods. The liquid phase and solid supported synthesis and the synthesis on soluble polymers are discussed. Different problems concerning the methods and implementation of the ODN synthesis are outlined depending on goals of using target oligomers.
authors: Institute of Chemical Biology and Fundamental Medicine, Lavrent'ev Ave, 8, Novosibirsk 630090, Russia. abramova@niboch.nsc.ru
authors: Tatyana
authors: T
authors: Abramova
mesh_terms: D057930:Click Chemistry; D003853:Deoxyribonucleosides / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D060327:Solid-Phase Synthesis Techniques
chemical_list: D003853:Deoxyribonucleosides; D009838:Oligodeoxyribonucleotides