title: Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita).
abstract: Abstract Twenty-three phenolic compounds were isolated from Dioscorea opposita by bioactivity-guided method and their inhibitory effect against pancreatic lipase was evaluated. A total of 15 isolates reduced lipase activity at IC50 values of less than 50 µM and 3,3',5-trihydroxy-2'-methoxybibenzyl showed the highest inhibition with an IC50 value of 8.8 µM. This study is a first to reveal the pancreatic lipase inhibitory activity by both D. opposita and its isolated compounds.
authors: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University , Seoul , South Korea .
authors: Min Hye
authors: MH
authors: Yang
authors: Young-Won
authors: YW
authors: Chin
authors: Kee Dong
authors: KD
authors: Yoon
authors: Jinwoong
authors: J
authors: Kim
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D027742:Dioscorea / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D010179:Pancreas / Q000201:enzymology*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013552:Swine
chemical_list: D004791:Enzyme Inhibitors; D010636:Phenols; D008049:Lipase