title: Investigation of STW 5 (Iberogast®) preventive effects in experimental sepsis.
abstract: BACKGROUND
  STW 5 (Iberogast(®)) is a well known herbal combination drug containing glycosides and flavonoids for which multiple pharmacological properties have been shown.
  
  
  OBJECTIVE
  In this study, attempts were made to assess whether STW 5, an aqueous ethanol solution, has a preventive effect against liver and lung pathological damage in rats after experimental induction of sepsis [cecal ligation and puncture (CLP)].
  
  
  METHODS
  Experimental sepsis was induced in rats using CLP operation. The rats (n = 36) were divided into six groups (six/group): Sham-operated (SOP); CLP; CLP + STW 5 (2.5, 5 and 10 mg/kg) and CLP + indomethacin. The drugs were injected intraperitoneally immediately after sepsis induction.
  
  
  RESULTS
  It was found that induction of sepsis 24 h after CLP was associated with significant liver and lung damage, also remaining after STW 5 administration.
  
  
  CONCLUSIONS
  It appears that STW 5, which has a pronounced efficacy in functional gastro-intestinal diseases, has no effect on septic liver and lung damage in the CLP rat model.
authors: Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran. dadkhah_bio@yahoo.com
authors: A
authors: A
authors: Dadkhah
authors: F
authors: F
authors: Fatemi
authors: J
authors: J
authors: Ashrafihelan
mesh_terms: D000818:Animals; D002432:Cecum / Q000382:microbiology / Q000601:surgery; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D008026:Ligation; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D020556:Neutrophil Infiltration / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011677:Punctures; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*
chemical_list: D010936:Plant Extracts; C039964:iberogast