title: Development of a universal CTL-based vaccine for influenza.
abstract: In pursuit of better influenza vaccines, many strategies are being studied worldwide. An attractive alternative is the generation of a broadly cross-reactive vaccine based on the induction of cytotoxic T-lymphocytes (CTL) directed against conserved internal antigens of influenza A virus. The feasibility of this approach using recombinant viral vectors has recently been demonstrated in mice and humans by several research groups. However, similar results might also be achieved through immunization with viral proteins expressed in a prokaryotic system formulated with the appropriate adjuvants and delivery systems. This approach would be much simpler and less expensive. Recent results from several laboratories seem to confirm this is as a valid option to be considered.
authors: Institute of Experimental Medicine and Biology of Cuyo (IMBECU-CONICET); Mendoza, Argentina; Animal Virology Center; Institute of Science and Technology Dr César Milstein; CONICET; Buenos Aires, Argentina.
authors: Diego Esteban
authors: DE
authors: Cargnelutti
authors: Institute of Experimental Medicine and Biology of Cuyo (IMBECU-CONICET); Mendoza, Argentina.
authors: María Victoria
authors: MV
authors: Sánchez
authors: Animal Virology Center; Institute of Science and Technology Dr César Milstein; CONICET; Buenos Aires, Argentina.
authors: Nora Marta
authors: NM
authors: Mattion
authors: Institute of Experimental Medicine and Biology of Cuyo (IMBECU-CONICET); Mendoza, Argentina.
authors: Eduardo Alberto
authors: EA
authors: Scodeller
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D003429:Cross Reactions; D004195:Disease Models, Animal; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology / Q000821:virology; D014764:Viral Proteins / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D007252:Influenza Vaccines; D014614:Vaccines, Synthetic; D014764:Viral Proteins
keywords: adjuvants; cellular immunity; cross-presentation; cytotoxic-T-lymphocytes; influenza vaccines; recombinant antigen