title: Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis.
abstract: Metabolism and immunity are inextricably linked both to each other and to organism-wide function, allowing mammals to adapt to changes in their internal and external environments. In the modern context of obesogenic diets and lifestyles, however, these adaptive responses can have deleterious consequences. In this Review, we discuss the pleiotropic actions of inflammation and insulin resistance in metabolic homeostasis and disease. An appreciation of the adaptive context in which these responses arose is useful for understanding their pathogenic actions in disease.
authors: Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA.
authors: Justin I
authors: JI
authors: Odegaard
authors: Ajay
authors: A
authors: Chawla
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D006706:Homeostasis; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007249:Inflammation / Q000503:physiopathology*; D007333:Insulin Resistance; D007962:Leukocytes / Q000502:physiology; D008659:Metabolic Diseases / Q000503:physiopathology*; D024821:Metabolic Syndrome / Q000503:physiopathology; D008660:Metabolism; D009765:Obesity / Q000503:physiopathology