title: Determinants of atherosclerosis in children and adolescents with diabetes type 1.
abstract: BACKGROUND
  To evaluate the degree of atherosclerosis in children and adolescents with type 1 diabetes and its correlation with risk factors, traditional and other, such as anti-oxidative capacity of circulating blood and level of lipid peroxidation.
  
  
  METHODS
  Forty children and adolescents with type 1 diabetes with mean age 13.7 years were compared with 20 age- and sex-matched healthy control subjects. Association of carotid artery intima-media thickness (cIMT) with different risk factors measured in children with type 1 diabetes was evaluated.
  
  
  RESULTS
  Mean carotid IMT was higher in subjects with diabetes (p 〈 0.01) and was strongly associated with total cholesterol with an odds ratio of 4.08 (p = 0.016), LDL-cholesterol with an odds ratio of 2.78 (p = 0.037), length of disease with an odds ratio of 1.87 (p = 0.007) and positive family history (first- and second-degree relatives) of diabetes and early CVD (heart attack and/or stroke before the age of 60 years) with an odds ratio of 6.8 (p = 0.007).
  
  
  CONCLUSIONS
  We found significantly increased cIMT in the diabetic patients compared to the healthy control subjects. Risk factors for the development of atherosclerosis included higher total and LDL-cholesterol, higher systolic blood pressure, positive family history of diabetes and early CVD and longer diabetes duration. In spite of the documented increased oxidative stress, we failed to establish a correlation between the oxidative stress parameters and cIMT values.
authors: Clinic for Children’s Internal Diseases, Clinical Centre, University of Nis, 18000 Nis, Serbia. stankovic_sandra@yahoo.com
authors: Sandra M
authors: SM
authors: Stanković
authors: Saša R
authors: SR
authors: Zivić
authors: Ljiljana
authors: L
authors: Šaranac
authors: Vesna
authors: V
authors: Cvetković
authors: Milica
authors: M
authors: Pešić
authors: Karin
authors: K
authors: Vasić
authors: Miodrag
authors: M
authors: Stanković
authors: Aleksandra
authors: A
authors: Topalović
authors: Tatjana
authors: T
authors: Cvetković
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis / Q000209:etiology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D008078:Cholesterol, LDL