title: Granulomatous slack skin. Histopathology diagnosis preceding clinical manifestations by 12 years.
abstract: BACKGROUND
  Granulomatous slack skin is a very rare subtype of T-cell cutaneous lymphoma, characterized by the slow development of cutaneous sagging, especially on flexural areas. Its behavior is indolent and the treatment, in the majority of cases, disappointing.
  
  
  METHODS
  We report a 54-year-old black patient with granulomatous slack skin, who at the beginning of the investigation showed intense xeroderma and generalized lymph node enlargement. The diagnosis was established based on histopathologic findings long before the disease's characteristic clinical presentation appeared.
  
  
  CONCLUSIONS
  During the twelve years of follow-up, the clinical manifestation evolved to marked skin looseness, most predominant in flexural regions, illustrating the clinical hallmark of granulomatous slack skin, long after first histological abnormalities were observed.
authors: Sector of Dermatology and Post Graduation Course - HUCFF-UFRJ and School of Medicine, Federal University of Rio de Janeiro, Brazil.
authors: Karen O
authors: KO
authors: Goldsztajn
authors: Beatriz
authors: B
authors: Moritz Trope
authors: Maria Elisa
authors: ME
authors: Ribeiro Lenzi
authors: Tullia
authors: T
authors: Cuzzi
authors: Marcia
authors: M
authors: Ramos-E-Silva
keywords: cutaneous T-cell lymphoma; diagnosis; granulomatous cutis laxa; granulomatous slack skin; lymphoma; mycosis fungoides; orcein staining; treatment