title: Twice malignant transformation of hypertrophic lichen planus.
abstract: Lichen planus is a chronic mucocutaneous T-cell-mediated disease, the cause of which remains unknown. The first case of lichen planus that transformed into squamous cell carcinoma was reported in 1903. The presented study concerns the case of a 62-year-old woman in whom twice malignant transformation of hypertrophic lichen planus in the dorsal part of the left foot developed. Several studies have pointed out the malignant transformation potential of lichen planus. Epidemiological studies from the last 20 years have revealed a malignant transformation rate of 0.27% per year, emphasizing the importance of the clinical follow-up of lichen planus patients.
authors: Department of Dermatology, Venereology and Pediatric Dermatology, Medical University, Lublin, Poland. dorota.krasowska@am.lublin.pl
authors: Dorota
authors: D
authors: Krasowska
authors: Katarzyna
authors: K
authors: Kozłowicz
authors: Małgorzata
authors: M
authors: Kowal
authors: Andrzej
authors: A
authors: Kurylcio
authors: Jolanta
authors: J
authors: Budzyńska-Włodarczyk
authors: Wojciech
authors: W
authors: Polkowski
authors: Grażyna
authors: G
authors: Chodorowska
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D005534:Foot Diseases / Q000209:etiology / Q000473:pathology / Q000601:surgery; D006801:Humans; D006984:Hypertrophy; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008010:Lichen Planus / Q000150:complications / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D013472:Sunlight / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents