title: Association of 14-bp insertion/deletion polymorphism of HLA-G gene with unexplained recurrent spontaneous abortion: a meta-analysis.
abstract: A meta-analysis was performed to assess the association of the human leukocyte antigen-G (HLA-G) 14 bp insertion (ins)/deletion (del) polymorphism with unexplained recurrent spontaneous abortions (URSA). The fixed or random effect pooled measure was selected based on the homogeneity test among studies that was evaluated with I². Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. In this meta-analysis, 14 studies with 1464 cases and 1247 controls corresponded to the inclusion criteria were included. Significant associations between 14 bp ins/del polymorphism and risk of URSA were observed in both dominant [random effect model (REM) OR = 1.469, 95% CI = 1.127-1.914] and codominant (REM OR = 1.195, 95% CI = 1.005-1.420) models. After excluding two articles that deviated from Hardy-Weinberg equilibrium in cases and sensitivity analysis, significant associations were also observed in dominant [fixed effect model (FEM) OR = 1.224, 95% CI = 1.020-1.470] and codominant (FEM OR = 1.158, 95% CI = 1.028-1.305) models. This meta-analysis suggests that the 14 bp ins HLA-G allele is associated with increased risk of URSA. The results are of importance to the clinical practice of URSA and infertility.
authors: Department of Public Health, Qingdao University Medical College, 266021 Qingdao, China.
authors: X
authors: X
authors: Wang
authors: W
authors: W
authors: Jiang
authors: D
authors: D
authors: Zhang
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D020029:Base Pairing / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D059951:HLA-G Antigens / Q000235:genetics*; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011247:Pregnancy; D017594:Publication Bias
chemical_list: D059951:HLA-G Antigens