title: [Genomic diagnosis in breast cancer practice].
abstract: Significant targeted molecules for breast cancer treatment are hormone receptor and HER2. Since the concept of an "intrinsic subtype" was proposed, breast cancers have been treated according to subtypes including Luminal A, B, HER2 and triple negative. In this article, gene testing useful as a prognostic factor and to predict the chemotherapeutic effect on ER-positive breast cancers will be introduced, although it has not been approved in Japan. Gene testing is useful but expensive so far; therefore, it will be used in parallel to conventional tools, i.e. HE-stained sections and immunohistochemical methods.
authors: Department of Pathology, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan. masuda.shinobu@nihon-u.ac.jp
authors: Shinobu
authors: S
authors: Masuda
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D005260:Female; D005820:Genetic Testing; D023281:Genomics; D006801:Humans; D007564:Japan; D058990:Molecular Targeted Therapy; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor