title: Impaired vasomotor function induced by the combination of hypertension and hypercholesterolemia.
abstract: Although it is well known that endothelial function is compromised in the presence of either hypertension (HTN) or hypercholesterolemia (HCh), less is known about whether and how the combination of these risk factors (HTN+HCh) results in impaired endothelium-dependent dilation (EDD). The aims of this study were to evaluate the influence of HTN+HCh on vasomotor function and to identify the mechanisms that underlie the altered vascular reactivity elicited by HTN+HCh. Endothelium-dependent and -independent vasomotor responses of aortic vessels were studied in mice with diet-induced HCh and/or HTN induced by chronic administration of either angiotensin II (AngII) or deoxycorticosterone acetate-salt. HTN+HCh elicited an impairment of EDD that appeared between each risk factor alone. Incubation with catalase resulted in more severe EDD impairment. Each risk factor enhanced vascular H₂O₂ production, but a larger response was noted with HTN+HCh. An attenuated EDD was not observed in AngII type 1a receptor deficient (AT1r(-/-)) mice, but AT1r(-/-) bone marrow chimeras exhibited more profound impairment compared with wild-type. HTN+HCh does not exert an additive effect of vasomotor dysfunction compared with either risk factor alone, and both H₂O₂ and blood cell-associated AT1r contribute to the impaired EDD responses in mice with HTN+HCh.
authors: Department of Physiology, Marmara University School of Medicine, Istanbul, Turkey.
authors: Hizir
authors: H
authors: Kurtel
authors: Stephen F
authors: SF
authors: Rodrigues
authors: Cigdem E
authors: CE
authors: Yilmaz
authors: Alper
authors: A
authors: Yildirim
authors: D Neil
authors: DN
authors: Granger
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D016026:Bone Marrow Transplantation; D015897:Comorbidity; D003900:Desoxycorticosterone / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology* / Q000503:physiopathology*; D006973:Hypertension / Q000139:chemically induced / Q000453:epidemiology* / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008901:Mineralocorticoids / Q000494:pharmacology; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors; D018183:Transplantation Chimera; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects / Q000502:physiology*
chemical_list: D008901:Mineralocorticoids; D044140:Receptor, Angiotensin, Type 1; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D000804:Angiotensin II; D003900:Desoxycorticosterone; D000109:Acetylcholine