title: Treatment of scabies: comparison of ivermectin vs. lindane lotion 1%.
abstract: Topical antiscabietics have poor compliance. This study aimed at comparing the efficacy and safety of oral ivermectin with topical lindane in treating scabies. In this clinical trial, 248 patients from 2 to 86 years of age were divided into two groups. Oral ivermectin was given to group A in a single dose of 200 μg/kg body weight. Group B received application of lindane lotion 1% twice at one-week interval. When there was no cure in two weeks, 2nd treatment was given with either drug in the respective group. A single dose of ivermectin provided a cure rate of 58.6% at two-week follow up, which increased to 92.7% with 2 doses at the end of 4-week interval. The application of lindane lotion 1% twice at one-week interval was effective in 44.3% of patients at two-week follow up, which increased to 71.7% after repeating the treatment for another two weeks. Single dose application of oral ivermectin was as effective as twice application of lindane lotion 1% at one-week interval. Two doses of ivermectin proved superior to lindane lotion 1% after repeating the treatment at 4-week follow up.
authors: Department of Dermatology, Islamic Azad university, Tabriz, Iran.
authors: Alireza
authors: A
authors: Mohebbipour
authors: Parviz
authors: P
authors: Saleh
authors: Mohamad
authors: M
authors: Goldust
authors: Mehdi
authors: M
authors: Amirnia
authors: Yousef Javad
authors: YJ
authors: Zadeh
authors: Ramin Mir
authors: RM
authors: Mohamadi
authors: Elham
authors: E
authors: Rezaee
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012532:Scabies / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000977:Antiparasitic Agents; D001556:Hexachlorocyclohexane; D007559:Ivermectin