title: Microbial biotransformations of bile acids as detected by electrospray mass spectrometry.
abstract: Many current experiments investigating the effects of diet, dietary supplements, and pre- and probiotics on the intestinal environments do not take into consideration the potential for using bile salts as markers of environmental change. Intestinal bacteria in vertebrates can metabolize bile acids into a number of different structures, with deamidation, hydroxyl group oxidation, and hydroxyl group elimination. Fecal bile acids are readily available to sample and contain a considerable structural complexity that directly relates to intestinal morphology, bile acid residence time in the intestine, and the species of microbial forms in the intestinal tract. Here we offer a classification scheme that can serve as an initial guide to interpret the different bile acid patterns expressed in vertebrate feces.
authors: Department of Medicine, University of California at San Diego, USA. lhagey@ucsd.edu
authors: Lee R
authors: LR
authors: Hagey
authors: Matthew D
authors: MD
authors: Krasowski
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis* / Q000378:metabolism*; D001711:Biotransformation; D004032:Diet; D019587:Dietary Supplements; D005243:Feces / Q000737:chemistry; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D013058:Mass Spectrometry / Q000379:methods*; D019936:Probiotics
chemical_list: D001647:Bile Acids and Salts