title: Lag normalization in an electrically coupled neural network.
abstract: Moving objects can cover large distances while they are processed by the eye, usually resulting in a spatially lagged retinal response. We identified a network of electrically coupled motion-coding neurons in mouse retina that act collectively to register the leading edges of moving objects at a nearly constant spatial location, regardless of their velocity. These results reveal a previously unknown neurophysiological substrate for lag normalization in the visual system.
authors: Department of Biology, University of Victoria, Victoria, British Columbia, Canada.
authors: Stuart
authors: S
authors: Trenholm
authors: David J
authors: DJ
authors: Schwab
authors: Vijay
authors: V
authors: Balasubramanian
authors: Gautam B
authors: GB
authors: Awatramani
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001703:Biophysics; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D017629:Gap Junctions / Q000187:drug effects / Q000502:physiology*; D006034:Glycyrrhetinic Acid / Q000494:pharmacology; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008959:Models, Neurological; D009039:Motion Perception / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D012160:Retina / Q000166:cytology; D013028:Space Perception / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics; D014795:Visual Pathways / Q000187:drug effects / Q000502:physiology*
chemical_list: D018398:Homeodomain Proteins; D014157:Transcription Factors; C485184:enhanced green fluorescent protein; C084059:Hb9 protein, mouse; D049452:Green Fluorescent Proteins; D006034:Glycyrrhetinic Acid