title: Larynx preservation for patients with locally advanced laryngeal cancer.
abstract: A 53-year-old man presented with a 6-month history of mild hoarseness, with no associated pain, dysphagia, or stridor. At nasoendoscopy, a lesion was detected involving the whole length of the left vocal cord, with abnormal mucosa also seen in the right ventricle (Fig 1). The left vocal cord movement was impaired. There were no palpable neck nodes. Biopsy under anesthesia revealed moderately differentiated squamous cell carcinoma. He was a current smoker of 30 cigarettes per day (45 pack-year smoking history), and he consumed four standard drinks of alcohol per day. His Eastern Cooperative Oncology Group performance status was 1, and he had no significant comorbidities. Radiologic review of his outside computed tomography scan noted that it was of poor quality, and a magnetic resonance imaging scan was recommended, which showed low-volume T4a disease based on focal thyroid cartilage penetration (Fig 2). A positron emission tomography (PET) scan revealed no evidence of nodal or distant metastasis.
authors: Peter MacCallum Cancer Centre, Locked Bag No. 1, A'Beckett Street, Melbourne, VI, Australia 8006.
authors: June
authors: J
authors: Corry
authors: Lester
authors: L
authors: Peters
authors: Stephen
authors: S
authors: Kleid
authors: Danny
authors: D
authors: Rischin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D059186:Chemoradiotherapy, Adjuvant / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D005472:Fluorouracil / Q000008:administration & dosage; D006685:Hoarseness / Q000209:etiology; D006801:Humans; D060828:Induction Chemotherapy; D007822:Laryngeal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D059351:Organ Sparing Treatments / Q000379:methods*; D012907:Smoking / Q000009:adverse effects; D016540:Smoking Cessation; D043823:Taxoids / Q000008:administration & dosage; D016896:Treatment Outcome; D014827:Vocal Cords / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D014987:Xerostomia / Q000209:etiology
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil