title: Role of autoimmunity in primary biliary cirrhosis.
abstract: Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the presence of serum autoantibodies and chronic nonsuppurative destructive cholangitis. The pathogenesis of PBC involves environmental factors, genetic predisposition and loss of immune tolerance. In recent years, it has become univocally accepted that an inappropriately activated immune response is one of the most important factors in PBC. In this study, the role of autoimmunity in PBC is summarized and a feasible research orientation is recommended.
authors: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100032, China.
authors: Tian-Yan
authors: TY
authors: Shi
authors: Feng-Chun
authors: FC
authors: Zhang
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000166:cytology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D018925:Chemokines / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007113:Immunity, Innate; D007075:Immunoglobulin M / Q000276:immunology; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D007694:Killer Cells, Natural / Q000166:cytology; D008105:Liver Cirrhosis, Biliary / Q000276:immunology* / Q000628:therapy; D051379:Mice; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D001323:Autoantibodies; D018925:Chemokines; D007075:Immunoglobulin M; D053645:Interleukin-2 Receptor alpha Subunit; D014580:Ursodeoxycholic Acid
keywords: Autoimmunity; Cellular immunity; Humoral immunity; Nonspecific immunity; Primary biliary cirrhosis