title: Nitrogen containing privileged structures and their solid phase combinatorial synthesis.
abstract: The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies of nitrogen containing privileged structures over the years.
authors: Pharmacy Department, Faculty of Technology & Engineering, The M S University of Baroda, Kala Bhavan, Vadodara-390001, Gujarat, India.
authors: Amit
authors: A
authors: Verma
authors: Mange Ram
authors: MR
authors: Yadav
authors: Rajani
authors: R
authors: Giridhar
authors: Navnit
authors: N
authors: Prajapati
authors: Avinash C
authors: AC
authors: Tripathi
authors: Shailendra K
authors: SK
authors: Saraf
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques; D013329:Structure-Activity Relationship
chemical_list: D006571:Heterocyclic Compounds; D011687:Purines; D011743:Pyrimidines; D001569:Benzodiazepines; D009584:Nitrogen