title: Glomerular filtration rate after a 12-wk resistance exercise program with post-exercise protein ingestion in community dwelling elderly.
abstract: OBJECTIVE
  Increased protein intake and resistance exercise can be beneficial for maintenance of lean body mass (LBM) in older adults. However, these factors could also negatively affect renal function. We investigated changes in renal function after a 12-wk resistance exercise program combined with protein supplementation in community dwelling older adults.
  
  
  METHODS
  Patients (N = 237, 73.7 ± 5.7 y, 58.2% female) participated in a 12-wk resistance exercise program (3 times/wk) designed to increase strength and muscle mass of major muscle groups. Participants were randomly assigned to one of three dietary supplements consumed directly after training: whey protein drink (20 g whey protein, 20 g carbohydrates), milk protein drink (20 g milk protein, 20 g carbohydrates), or carbohydrate drink (40 g carbohydrates). Renal function was estimated as glomerular filtration rate (GFR, Cockcroft-Gault formula), and dietary intake was measured as 3-d-weighed food record at baseline and endpoint.
  
  
  RESULTS
  During the intervention, energy intake did not increase. Carbohydrate intake increased in the carbohydrate group and protein intake increased in the milk group, both approximately in accordance with the supplementation. In the whey group, protein intake did not increase, but carbohydrate intake did. GFR increased after the intervention (+4.4 mL/min/1.73 m2; P < 0.001), and the changes were similar in men and women or in the age quartiles. Changes in GFR at endpoint were not associated with LBM, dietary supplements, or total protein intake.
  
  
  CONCLUSIONS
  A 12-wk resistance exercise program combined with protein supplementation in community dwelling older adults does not negatively affect GFR. The supplementation had only minor effects on total dietary intake.
authors: Unit for Nutrition Research, National University Hospital and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. alfonsra@hi.is
authors: Alfons
authors: A
authors: Ramel
authors: Atli
authors: A
authors: Arnarson
authors: Olof G
authors: OG
authors: Geirsdottir
authors: Palmi V
authors: PV
authors: Jonsson
authors: Inga
authors: I
authors: Thorsdottir
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001628:Beverages; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000494:pharmacology; D004044:Dietary Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D019587:Dietary Supplements; D002149:Energy Intake / Q000187:drug effects*; D015444:Exercise / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008892:Milk; D008894:Milk Proteins / Q000494:pharmacology; D055070:Resistance Training; D014891:Weight Lifting / Q000502:physiology*; D000067816:Whey Proteins
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D008894:Milk Proteins; D000067816:Whey Proteins