title: Construction and accuracy assessment of patient-specific biocompatible drill template for cervical anterior transpedicular screw (ATPS) insertion: an in vitro study.
abstract: BACKGROUND
  With the properties of three-column fixation and anterior-approach-only procedure, anterior transpedicular screw (ATPS) is ideal for severe multilevel traumatic cervical instabilities. However, the accurate insertion of ATPS remains challenging. Here we constructed a patient-specific biocompatible drill template and evaluated its accuracy in assisting ATPS insertion.
  
  
  METHODS
  After ethical approval, 24 formalin-preserved cervical vertebrae (C2-C7) were CT scanned. 3D reconstruction models of cervical vertebra were obtained with 2-mm-diameter virtual pin tracts at the central pedicles. The 3D models were used for rapid prototyping (RP) printing. A 2-mm-diameter Kirschner wire was then inserted into the pin tract of the RP model before polymethylmethacrylate was used to construct the patient-specific biocompatible drill template. After removal of the anterior soft tissue, a 2-mm-diameter Kirschner wire was inserted into the cervical pedicle with the assistance of drill template. Cadaveric cervical spines with pin tracts were subsequently scanned using the same CT scanner. A 3D reconstruction was performed of the scanned spines to get 3D models of the vertebrae containing the actual pin tracts. The deviations were calculated between 3D models with virtual and actual pin tracts at the middle point of the cervical pedicle. 3D models of 3.5 mm-diameter screws were used in simulated insertion to grade the screw positions.
  
  
  RESULTS
  The patient-specific biocompatible drill template was constructed to assist ATPS insertion successfully. There were no significant differences between medial/lateral deviations (P = 0.797) or between superior/inferior deviations (P = 0.741). The absolute deviation values were 0.82±0.75 mm and 1.10±0.96 mm in axial and sagittal planes, respectively. In the simulated insertion, the screws in non-critical position were 44/48 (91.7%).
  
  
  CONCLUSIONS
  The patient-specific drill template is biocompatible, easy-to-apply and accurate in assisting ATPS insertion. Its clinical applications should be further researched.
authors: Department of Anatomy, Guangdong Provincial Key laboratory of Medical Biomechanics, School of Basic Medicine Science, Southern Medical University, Guangzhou, Guangdong, China.
authors: Maoqing
authors: M
authors: Fu
authors: Lijun
authors: L
authors: Lin
authors: Xiangxue
authors: X
authors: Kong
authors: Weidong
authors: W
authors: Zhao
authors: Lei
authors: L
authors: Tang
authors: Jianyi
authors: J
authors: Li
authors: Jun
authors: J
authors: Ouyang
mesh_terms: D000368:Aged; D001672:Biocompatible Materials / Q000494:pharmacology*; D001863:Bone Screws; D002574:Cervical Vertebrae / Q000187:drug effects*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D066298:In Vitro Techniques; D008297:Male; D008422:Materials Testing / Q000379:methods*; D008875:Middle Aged; D008953:Models, Anatomic; D019637:Orthopedic Procedures / Q000379:methods*
chemical_list: D001672:Biocompatible Materials