title: Prevalence and risk factors of prolonged QTc interval among Chinese patients with type 2 diabetes.
abstract: OBJECTIVE
  The aim of this study was to evaluate the prevalence and the risk factors of prolonged QTc interval among Chinese patients with type 2 diabetes.
  
  
  METHODS
  The retrospective study included 3156 outpatients from the Diabetes Centre, the 306th Hospital of PLA, during the period from September 2003 to June 2010. QT interval was measured manually in the 12-lead conventional electrocardiogram. The QT interval corrected for heart rate (QTc) was calculated using Bazett's formula. Additional demographic and laboratory data were also collected. Potential risk factors of prolonged QTc interval were assessed using multivariable regression.
  
  
  RESULTS
  The prevalence of prolonged QTc interval among Chinese patients with type 2 diabetes was 30.1%. Height (OR 0.156, 95% CI 0.032~0.748), waist circumference (OR 1.025, 95% CI 1.010~1.040), diastolic blood pressure (OR 1.016, 95% CI 1.007~1.026), postprandial glucose (OR 1.040, 95% CI 1.022~1.059), fasting insulin (OR 1.014, 95% CI 1.003~1.025), and presence of microalbuminuria (OR 1.266, 95% CI 1.033~1.551) were significant risk factors.
  
  
  CONCLUSIONS
  The prevalence of prolonged QTc interval among Chinese patients with type 2 diabetes is high. Risk factors for prolongation of QTc interval were low height, high waist circumference, increasing diastolic blood pressure levels, high postprandial glucose levels, high fasting insulin levels, and presence of microalbuminuria.
authors: Diabetes Center, The 306th Hospital of PLA, Beijing 100101, China.
authors: Xiang
authors: X
authors: Li
authors: Hui
authors: H
authors: Ren
authors: Zhang-rong
authors: ZR
authors: Xu
authors: Yan-jun
authors: YJ
authors: Liu
authors: Xiao-pin
authors: XP
authors: Yang
authors: Jian-qin
authors: JQ
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000208:ethnology; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001827:Body Height / Q000208:ethnology; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000208:ethnology* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008133:Long QT Syndrome / Q000175:diagnosis / Q000208:ethnology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010044:Outpatient Clinics, Hospital; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D055105:Waist Circumference / Q000208:ethnology
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin