title: Effectiveness of 17-α-hydroxyprogesterone caproate on preterm birth prevention in women with history-indicated cerclage.
abstract: OBJECTIVE
  To determine whether 17-α-hydroxyprogesterone caproate (17P) reduces the incidence of preterm birth in women with a history-indicated cerclage.
  
  
  METHODS
  Retrospective cohort study of women who received a cerclage for a prior preterm birth, analyzed based on exposure to 17P. The primary outcome variable was delivery < 35 weeks. Secondary outcomes were preterm birth < 37, 32, 28, and 24 weeks; interval between cerclage placement and delivery; gestational age at delivery; and infant birth weight.
  
  
  RESULTS
  Fourteen women received 17P and 80 did not. Baseline characteristics did not differ between these two groups. Preterm delivery at < 35 weeks did not differ between those who received 17P and those who did not (29% versus 15%, p = 0.46). There were no significant differences between the groups for any other outcome.
  
  
  CONCLUSIONS
  17P does not appear to have an effect on preterm birth < 35 weeks in women with a history-indicated cerclage.
authors: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
authors: A Dhanya
authors: AD
authors: Mackeen
authors: Timothy J
authors: TJ
authors: Rafael
authors: Jillian
authors: J
authors: Zavodnick
authors: Vincenzo
authors: V
authors: Berghella
mesh_terms: D000077713:17 alpha-Hydroxyprogesterone Caproate; D000328:Adult; D001724:Birth Weight; D023802:Cerclage, Cervical; D054791:Cervical Length Measurement; D005260:Female; D005865:Gestational Age; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use*; D011247:Pregnancy; D047928:Premature Birth / Q000517:prevention & control*; D011372:Progestins / Q000627:therapeutic use*; D012189:Retrospective Studies; D013997:Time Factors; D002581:Uterine Cervical Incompetence / Q000188:drug therapy
chemical_list: D006908:Hydroxyprogesterones; D011372:Progestins; D000077713:17 alpha-Hydroxyprogesterone Caproate