title: Meta-analysis of association between the -1438A/G (rs6311) polymorphism of the serotonin 2A receptor gene and major depressive disorder.
abstract: OBJECTIVE
  Major depressive disorder (MDD) is a severe psychiatric disorder with a lifetime prevalence of approximately 10-15%. Previous pharmacological studies suggested that the serotonin 2A receptor (5-HTR2A) was one of the major pharmacological therapeutic targets  for MDD. Recently, genetic studies investigated the association between the polymorphism rs6311 of the 5-HTR2A gene and MDD. However, the results of these studies were inconsistent. To evaluate these conflicting findings, we performed the current meta-analysis.
  
  
  METHODS
  Eleven articles  form PubMed and Chinese National Knowledge Infrastructure databases were selected including 1491 patients and 2937 controls for the meta-analysis through assessing in detail. All statistical analyses were performed by RevMan (v.5·1) program.
  
  
  RESULTS
  No significant association  between the 5-HTR2A gene SNP rs6311 and the risk of MDD was observed by four genetic models in the current meta-analysis (P = 0·12 for A versus G; P = 0·11 for AA versus GG; P = 0·06 for AA+AG versus GG; P = 0·24  for AG+GG versus AA). The calculated generalized odds ratio also revealed that the SNP rs6311 did not confer an increased risk to MDD. Moreover, the sensitivity analysis indicated that the result of meta-analysis is instable.
  
  
  CONCLUSIONS
  Although the current meta-analysis indicated  that the SNP rs6311 within the 5-HTR2A gene may be not associated with an increased risk for MDD, the results require further study to acquire more direct evidence.
authors: Department of Geriatrics, Wuxi, China.
authors: Chunhui
authors: C
authors: Jin
authors: Wenwei
authors: W
authors: Xu
authors: Jianmin
authors: J
authors: Yuan
authors: Guoqiang
authors: G
authors: Wang
authors: Zaohuo
authors: Z
authors: Cheng
mesh_terms: D016208:Databases, Factual / Q000706:statistics & numerical data; D003865:Major Depressive Disorder / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012680:Sensitivity and Specificity
chemical_list: D044402:Receptor, Serotonin, 5-HT2A