title: Enantioselective construction of oxa- and aza-angular triquinanes through tandem [4 + 1]/[3 + 2] cycloaddition of sulfur ylides and nitroolefins.
abstract: A formal [4 + 1]/[3 + 2] cycloaddition sequence of sulfur ylides and alkene-tethered nitroolefins has been developed. The use of (R)-binol-derived chiral sulfide leads to an asymmetric process that allows the construction of oxa- and aza-angular triquinanes in good to excellent diastereo- and enantioselectivities.
authors: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
authors: Jing
authors: J
authors: An
authors: Liang-Qiu
authors: LQ
authors: Lu
authors: Qing-Qing
authors: QQ
authors: Yang
authors: Tao
authors: T
authors: Wang
authors: Wen-Jing
authors: WJ
authors: Xiao
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D009284:Naphthols; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000475:Alkenes; C406944:BINOL, naphthol; D009284:Naphthols; D009574:Nitro Compounds; D013457:Sulfur Compounds