title: Cu-catalyzed direct C-H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles.
abstract: An efficient, regioselective C-5 arylation of thiazolo[3,2-b]-1,2,4-triazoles catalyzed by a simple copper catalyst was developed. This arylation proceeded smoothly and tolerated a variety of functional groups (44 examples). A wide range of functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives were obtained in high yields (up to 99% yield). Possible catalytic cycles of the arylation were also discussed.
authors: Key Laboratory of Mesoscopic Chemistry of Ministry of Education, Center for Multimolecular Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
authors: Zengyang
authors: Z
authors: Xie
authors: Xiaojun
authors: X
authors: Zhu
authors: Yangfan
authors: Y
authors: Guan
authors: Dunru
authors: D
authors: Zhu
authors: Hongwen
authors: H
authors: Hu
authors: Chen
authors: C
authors: Lin
authors: Yi
authors: Y
authors: Pan
authors: Juli
authors: J
authors: Jiang
authors: Leyong
authors: L
authors: Wang
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D013844:Thiazoles; D014230:Triazoles; D003300:Copper