title: Triglyceride accumulation inhibitory effects of phenylpropanoid glycosides from Boschniakia rossica Fedtsch et Flerov.
abstract: Bioassay-guided fractionation led to isolation of five new phenylpropanol glycosides, rossicasides G (1), H (2), I (3), J (4), and K (5), together with seven known compounds (6-12) from Boschniakia rossica. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI-TOF-MS, 1D and 2D NMR). Activity screening results showed that some isolates had TG accumulation inhibitory effects in HepG2 cells. Furthermore, the structure-activity relationship was partly clarified.
authors: Tianjin State Key Laboratory of Modern Chinese Medicine, Nankai District, Tianjin, China.
authors: Yi
authors: Y
authors: Zhang
authors: Chunhua
authors: C
authors: Wu
authors: Lingling
authors: L
authors: Guo
authors: Yue
authors: Y
authors: Chen
authors: Lifeng
authors: L
authors: Han
authors: Erwei
authors: E
authors: Liu
authors: Xiumei
authors: X
authors: Gao
authors: Tao
authors: T
authors: Wang
mesh_terms: D019440:Anti-Obesity Agents / Q000302:isolation & purification*; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification*; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D031670:Orobanchaceae / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D020005:Propanols / Q000737:chemistry / Q000302:isolation & purification*; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000378:metabolism
chemical_list: D019440:Anti-Obesity Agents; D004187:Disaccharides; D020005:Propanols; D014280:Triglycerides