title: Amphetamine and methamphetamine have a direct and differential effect on BV2 microglia cells.
abstract: A comparative analysis of the direct effects of amphetamine and methamphetamine exposure on BV2 microglia cells in the presence and absence of cellular debris was performed. A significant dose-dependent and treatment-dependent effect of amphetamine and methamphetamine on BV2 cells was demonstrated: methamphetamine, but not amphetamine, inhibited phagocytosis, and a differential regulation of cytokines was observed in response to amphetamine and methamphetamine.
authors: Department of Biology, Department of Psychology, North Georgia College and State University, 82 College Circle, Dahlonega, GA 30597, USA. rashanks@northgeorgia.edu
authors: R A
authors: RA
authors: Shanks
authors: J R
authors: JR
authors: Anderson
authors: J R
authors: JR
authors: Taylor
authors: S A
authors: SA
authors: Lloyd
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D017628:Microglia / Q000166:cytology / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects
chemical_list: D016207:Cytokines; D008694:Methamphetamine; D000661:Amphetamine