title: Primary Mucinous Cystadenocarcinoma of the Breast: Cytologic Finding and Expression of MUC5 Are Different from Mucinous Carcinoma.
abstract: Mucinous cystadenocarcinoma (MCA) in the breast is a rare neoplasm. There have been 13 cases of primary breast MCA reported. The MCA presents as a large, partially cystic mass in postmenopausal woman with a good prognosis. The microscopic findings resemble those of ovarian, pancreatic, or appendiceal MCA. The aspiration findings showed mucin-containing cell clusters in the background of mucin and necrotic material. The cell clusters had intracytoplasmic mucin displacing atypical nuclei to the periphery. Histologically, the tumor revealed an abundant mucin pool with small floating clusters of mucin-containing tumor cells. There were also small cysts lined by a single layer of tall columnar mucinous cells, resembling those of the uterine endocervix. The cancer cells were positive for mucin (MUC) 5 and negative for MUC2 and MUC6. This mucin profile is different from ordinary mucinous carcinoma and may be a unique characteristic of breast MCA.
authors: Department of Pathology, Gangnam Sevrance Hsopital, Yonsei University College of Medicine, Seoul, Korea.
authors: Sung Eun
authors: SE
authors: Kim
authors: Ji Hye
authors: JH
authors: Park
authors: Soonwon
authors: S
authors: Hong
authors: Ja Seung
authors: JS
authors: Koo
authors: Joon
authors: J
authors: Jeong
authors: Woo-Hee
authors: WH
authors: Jung
keywords: Breast; MUC2; MUC5; Mucinous cystadenocarcinoma