title: Double strand breaks: hurdles for RNA polymerase II transcription?
abstract: DNA lesions pose a physical obstacle to DNA-dependent cellular transactions such as replication and transcription. A great deal is known regarding RNA polymerase II (RNAP II) transcription stalling in the presence of lesions induced by UV, but recent studies have uncovered previously uncharacterized behavior of the RNAP II machinery in the presence of double strand breaks (DSBs). These new data, although contradictory, contribute to our understanding of a vital cellular mechanism that defends against the production of aberrant transcripts and protects cell viability.
authors: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR 7104 CNRS; UdS, INSERM U964, BP 10142, F-67404 Illkirch Cedex, CU de Strasbourg, France.
authors: Tibor
authors: T
authors: Pankotai
authors: Evi
authors: E
authors: Soutoglou
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D020868:Gene Silencing; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D012319:RNA Polymerase II