title: Deep cerebral microbleeds are negatively associated with HDL-C in elderly first-time ischemic stroke patients.
abstract: BACKGROUND
  Cerebral microbleeds (CMBs) detected on T2*-weighted MRI gradient-echo have been associated with increased risk of cerebral infarction. We evaluated risk factors for these lesions in a cohort of first-time ischemic stroke patients.
  
  
  METHODS
  Presence of CMBs in consecutive first-time ischemic stroke patients was evaluated. The location of CMBs was classified by cerebral region as strictly lobar (lobar CMBs) and deep or infratentorial (deep CMBs). Logistic regression analysis was performed to determine the contribution of lipid profile to the presence of CMBs.
  
  
  RESULTS
  One hundred and sixteen patients with a mean age of 70±10years were recruited. CMBs were present in 74 patients. The deep CMBs group had significantly lower HDL-C levels than those without CMBs. In univariable analysis, advanced periventricular hyperintensity grade (PVH>2) and decreased HDL-C were significantly associated with the deep but not the lobar CMB group. On logistic regression analysis, HDL-C (beta=-0.06, p=0.002) and PVH grade >2 (beta=3.40, p=0.005) were independent determinants of deep CMBs.
  
  
  CONCLUSIONS
  Low HDL-C may be a risk factor of deep CMBs, including advanced PVH status, in elderly patients with acute ischemic stroke. Management of HDL-C levels might be a therapeutic target for the prevention of recurrence of stroke.
authors: Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. migase@m.ehime-u.ac.jp
authors: Michiya
authors: M
authors: Igase
authors: Katsuhiko
authors: K
authors: Kohara
authors: Keiji
authors: K
authors: Igase
authors: Shiro
authors: S
authors: Yamashita
authors: Mutsuo
authors: M
authors: Fujisawa
authors: Ryosuke
authors: R
authors: Katagi
authors: Tetsuro
authors: T
authors: Miki
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D008076:Cholesterol, HDL