title: Restless legs syndrome induced by quetiapine: report of seven cases and review of the literature.
abstract: We report on seven cases of restless legs syndrome (RLS) in patients treated with quetiapine. Small doses (50-250 mg at bedtime) provoked RLS in a dose-dependent way. Most patients suffered from an affective disorder and all were treated concomitantly with antidepressants. A search of the literature revealed a further nine cases of RLS concerning quetiapine, also afflicting only patients with affective disorders. Quetiapine seems to carry a special risk for RLS in this sort of patient. Possible causes for this concurrence are discussed.
authors: Department of Psychiatry 1, OÖ LNK Wagner-Jauregg, Linz, Austria. hans.rittmannsberger@gespag.at
authors: Hans
authors: H
authors: Rittmannsberger
authors: Regina
authors: R
authors: Werl
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003987:Dibenzothiazepines / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy; D008875:Middle Aged; D000069348:Quetiapine Fumarate; D012148:Restless Legs Syndrome / Q000139:chemically induced*
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate