title: [Anticitrulin antibody and the extra-articular manifestations in rheumatoid arthritis].
abstract: A large proportion of rheumatoid arthritis (RA) patients develop extra-articular manifestations (EAM), which are associated with morbidity and early mortality. Anti cyclic citrullinated peptide (ACCP) antibody has proven to be highly specific for the diagnosis of RA, associated with severe joint damage and may have some role in the pathogenesis of EAM. The aim of this study was to determine the relationship between ACCP antibody and the presence of EAM in RA patients. Seventy four RA patients (ACR 1987) with EAM, > 18 years, more than 6 months duration were included, and an EAM free control, matched by sex and age, for each patient. Demographic, clinical and laboratory variables were compared using t-test, chi-square or Mann-Whitney test. Multivariate analysis was performed: p = 0.05. Patients with EAM presented a greater value of ACCP antibody (116 vs. 34, p < 0.01) and rheumatoid factor (108 vs. 34.5, p < 0.01). Independent association with current smoking habit (p = 0.02, OR = 3.78, 95%: 1.17-12.2), RF positive (p = 0.04, OR 3.23, CI 95%: 1.04 to 11.8) and ACCP antibody positive (p = 0.04, OR 3.23, 95% CI: 1.04-10) was found. The patients with xerostomia (109 vs. 34, p = 0.04), xerophthalmia (150 vs. 34, p < 0.01), subcutaneous nodules (141 vs. 34, p < 0.01) and pulmonary fibrosis (158 vs. 34, p = 0.04) had a higher degree of the ACCP antibody, than controls. In conclusion, ACCP antibody positive, RF positive and smoking were independent risk factors for the development of MEXA.
authors: Servicio de Reumatología, Hospital Privado Centro Médico de Córdoba SA, Córdoba. hayesalinas@gmail.com
authors: María Jezabel
authors: MJ
authors: Haye Salinas
authors: Soledad
authors: S
authors: Retamozo
authors: Lorena
authors: L
authors: Vetorazzi
authors: Natalia
authors: N
authors: Peano
authors: Patricia Ericka Díaz
authors: PE
authors: Cuiza
authors: María Sol Castaños
authors: MS
authors: Menescardi
authors: Evangelina María
authors: EM
authors: Miretti
authors: Laura Mariela
authors: LM
authors: Encinas
authors: Ana Cecilia
authors: AC
authors: Alvarez
authors: Verónica
authors: V
authors: Saurit
authors: Alejandro
authors: A
authors: Alvarellos
authors: Francisco
authors: F
authors: Caeiro
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002956:Citrulline / Q000276:immunology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000276:immunology*; D011658:Pulmonary Fibrosis / Q000276:immunology; D012217:Rheumatoid Factor / Q000097:blood; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014985:Xerophthalmia / Q000276:immunology*; D014987:Xerostomia / Q000276:immunology*
chemical_list: D010446:Peptide Fragments; D002956:Citrulline; D012217:Rheumatoid Factor