title: A cutoff point for arterial stiffness using the cardio-ankle vascular index based on carotid arteriosclerosis.
abstract: The cardio-ankle vascular index (CAVI) has been widely accepted as a good indicator of arteriosclerosis. However, the lack of a reliable diagnostic criterion for CAVI hampers the proper clinical screening for arteriosclerosis using CAVI and impedes the prompt treatment of cardiovascular disease (CVD). There is an urgent need to determine a criterion for CAVI in arteriosclerosis prevention. We conducted a cross-sectional study to determine this criterion based on receiver operating characteristic (ROC) analyses in a Chinese population consisting of 328 participants. CAVI was measured in duplicate, and carotid ultrasound detection was performed in a quiet environment by well-trained physicians. After multivariate adjustment, CAVI was positively associated with the risk of carotid arteriosclerosis. Compared with participants in the lowest tertile of CAVI (5.15-7.40), those in the medium (7.41-8.65) and highest (8.66-13.60) tertiles had odds ratios (95% confidence interval) of 2.2 (1.0, 4.9) and 4.4 (1.5, 13.3), respectively, for developing carotid arteriosclerosis (P trend=0.007). The areas under the ROC curve (AUC) of the male, female and pooled populations were 0.789, 0.897 and 0.856, respectively. The cutoff point of CAVI≥8.0 resulted in the largest sensitivity and specificity. Furthermore, CAVI and age acted synergistically to increase the risk of carotid arteriosclerosis. CAVI≥8.0 may be an optimal cutoff point for carotid arteriosclerosis prediction. The older population with higher CAVI scores had a higher risk of carotid arteriosclerosis. Additional large prospective studies are needed to confirm our findings.
authors: Physical Examination Center, The 1st Affiliated Hospital of Anhui Medical University, Hefei, China.
authors: Huaqing
authors: H
authors: Hu
authors: Huan
authors: H
authors: Cui
authors: Weixing
authors: W
authors: Han
authors: Liangping
authors: L
authors: Ye
authors: Wenting
authors: W
authors: Qiu
authors: Hui
authors: H
authors: Yang
authors: Chuanwu
authors: C
authors: Zhang
authors: Xiaojuan
authors: X
authors: Guo
authors: Guangyun
authors: G
authors: Mao
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000842:Ankle / Q000098:blood supply*; D044466:Asian People; D001783:Blood Flow Velocity; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002340:Carotid Artery Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging / Q000473:pathology; D011237:Predictive Value of Tests; D012372:ROC Curve; D012016:Reference Values; D012307:Risk Factors; D012959:Socioeconomic Factors; D014463:Ultrasonography; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult