title: Exploring the unique reactivity of diazoesters: an efficient approach to chiral β-amino acids.
abstract: The development of a highly stereospecific process for the C-O to C-N exchange with retention of configuration is described. This transformation enables access to optically enriched β-amido-α-diazoesters. These products are transformed to β-amino acids not readily accessible using known methods.
authors: Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@stanford.edu
authors: Barry M
authors: BM
authors: Trost
authors: Sushant
authors: S
authors: Malhotra
authors: Pascal
authors: P
authors: Ellerbrock
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D007097:Imines / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D001391:Azo Compounds; D004952:Esters; D007097:Imines