title: Tritylamine as an ammonia surrogate in the Ugi tetrazole synthesis.
abstract: The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described in satisfactory to good yields. N-Unsubstituted α-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives.
authors: Department for Drug Design, University of Groningen, A. Deusinglaan 1, Groningen 9713AV, The Netherlands.
authors: Ting
authors: T
authors: Zhao
authors: André
authors: A
authors: Boltjes
authors: Eberhardt
authors: E
authors: Herdtweck
authors: Alexander
authors: A
authors: Dömling
mesh_terms: D000641:Ammonia / Q000737:chemistry*; D001596:Benzylamines / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
chemical_list: D001596:Benzylamines; D013777:Tetrazoles; D014320:Triphenylmethyl Compounds; C539851:triphenylmethylamine; D000641:Ammonia