title: [High-risk patients with aortic valve stenosis. Interventional therapy].
abstract: Aortic valve stenosis is the most prevalent, clinically significant valvular disorder in adult patients. Surgical valve replacement is the standard therapy for patients with symptomatic and severe aortic stenosis; however, many patients are suboptimal candidates for surgery due to age and co-morbidities. The development of transcatheter aortic valve implantation (TAVI) has broadened the therapeutic options, especially in high-risk patients. The first randomized study comparing surgical valve replacement with TAVI in operable high-risk patients show similar mortality and reduction in symptoms after a 2-year follow-up. These data support the use of this technique in high-risk patients with severe aortic stenosis.
authors: Abteilung Innere Medizin III-Kardiologie, Angiologie und Pneumologie, Medizinische Universitätsklinik Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany. raffi.bekeredjian@med.uni-heidelberg.de
authors: R
authors: R
authors: Bekeredjian
authors: S T
authors: ST
authors: Pleger
authors: E
authors: E
authors: Chorianopoulos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000601:surgery*; D006328:Cardiac Catheterization / Q000295:instrumentation / Q000379:methods* / Q000639:trends*; D057510:Endovascular Procedures; D005544:Forecasting; D006350:Heart Valve Prosthesis / Q000639:trends*; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation / Q000379:methods* / Q000639:trends*; D006801:Humans; D018570:Risk Assessment