title: Association of TNF-α-308 and -238 polymorphisms with risk of cervical cancer: a meta-analysis.
abstract: Published data on the associations between tumor necrosis factor-alpha (TNF-α) promoter -308G>A and -238G>A polymorphisms and cervical cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Data were collected from MEDLINE and PubMed databases. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated in a fixed/random effect model. 13 separate studies including 3294 cases and 3468 controls were involved in the meta-analysis. We found no association between TNF-α-308G>A polymorphism and cervical cancer in overall population. In subgroup analysis, significantly elevated risks were found in Caucasian population (A vs. G: OR=1.43, 95% CI=1.00- 2.03; AA vs. GG: OR=2.09, 95% CI=1.34-3.25; Recessive model: OR=2.09, 95% CI=1.35-3.25) and African population (GA vs. GG: OR=1.53, 95% CI=1.02-2.30). An association of TNF-α-238G>A polymorphism with cervical cancer was found (A vs. G: OR=0.61, 95% CI=0.47-0.78; GA vs. GG: OR=0.59, 95% CI=0.45-0.77; Dominant model: OR=0.59, 95% CI=0.46-0.77). When stratified by ethnicity, similar association was observed in Caucasian population (A vs. G: OR=0.62, 95% CI=0.46-0.84; GA vs. GG: OR=0.59, 95% CI=0.43-0.82; Dominant model: OR=0.60, 95% CI=0.44-0.83). In summary, this meta-analysis suggests that TNF-α-238A allele significantly decreased the cervical cancer risk, and the TNF-α-308G>A polymorphism is associated with the susceptibility to cervical cancer in Caucasian and African population.
authors: Department of Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, China.
authors: Feng
authors: F
authors: Pan
authors: Jing
authors: J
authors: Tian
authors: Chu-Shu
authors: CS
authors: Ji
authors: Yi-Fu
authors: YF
authors: He
authors: Xing-Hua
authors: XH
authors: Han
authors: Yong
authors: Y
authors: Wang
authors: Jian-Ping
authors: JP
authors: Du
authors: Feng-Shou
authors: FS
authors: Jiang
authors: Ying
authors: Y
authors: Zhang
authors: Yue-Yin
authors: YY
authors: Pan
authors: Bing
authors: B
authors: Hu
mesh_terms: D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000209:etiology*
chemical_list: D014409:Tumor Necrosis Factor-alpha