title: High-fat diet acutely affects circadian organisation and eating behavior.
abstract: The organisation of timing in mammalian circadian clocks optimally coordinates behavior and physiology with daily environmental cycles. Chronic consumption of a high-fat diet alters circadian rhythms, but the acute effects on circadian organisation are unknown. To investigate the proximate effects of a high-fat diet on circadian physiology, we examined the phase relationship between central and peripheral clocks in mice fed a high-fat diet for 1 week. By 7 days, the phase of the liver rhythm was markedly advanced (by 5 h), whereas rhythms in other tissues were not affected. In addition, immediately upon consumption of a high-fat diet, the daily rhythm of eating behavior was altered. As the tissue rhythm of the suprachiasmatic nucleus was not affected by 1 week of high-fat diet consumption, the brain nuclei mediating the effect of a high-fat diet on eating behavior are likely to be downstream of the suprachiasmatic nucleus.
authors: Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA. julie.pendergast@vanderbilt.edu
authors: Julie S
authors: JS
authors: Pendergast
authors: Katrina L
authors: KL
authors: Branecky
authors: William
authors: W
authors: Yang
authors: Kate L J
authors: KL
authors: Ellacott
authors: Kevin D
authors: KD
authors: Niswender
authors: Shin
authors: S
authors: Yamazaki
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D059305:Diet, High-Fat / Q000009:adverse effects*; D005247:Feeding Behavior / Q000502:physiology*; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology*