title: Diffuse alveolar hemorrhage in patients with hematological malignancies: HRCT patterns of pulmonary involvement and disease course.
abstract: OBJECTIVE
  To analyze high-resolution computed tomography (HRCT) patterns of lung involvement and disease course in patients with hematological malignancies experiencing diffuse alveolar hemorrhage (DAH) after chemotherapy ± allogeneic stem cell transplantation (allo-SCT).
  
  
  METHODS
  Sixteen patients experiencing DAH after chemotherapy ± allo-SCT were enrolled. A total of 74 computed tomography (CT) scans obtained before, during, and after onset of DAH were evaluated retrospectively.
  
  
  RESULTS
  CT features of DAH are each, by oneself, nonspecific. However, conjoint bilateral, diffuse, and dependent ground glass opacity ± crazy paving, accompanied by airspace bronchograms, should suggest this complication. The HRCT course comprises a wide range of trends that are not predictive for patient's outcome, but progression of parenchymal consolidations at follow up was more often detrimental.
authors: Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, 72076 Tübingen, Germany. daniel.spira@med.uni-tuebingen.de
authors: Daniel
authors: D
authors: Spira
authors: Stefan
authors: S
authors: Wirths
authors: Felix
authors: F
authors: Skowronski
authors: Jan
authors: J
authors: Pintoffl
authors: Sascha
authors: S
authors: Kaufmann
authors: Harald
authors: H
authors: Brodoefel
authors: Marius
authors: M
authors: Horger
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D006470:Hemorrhage / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D013256:Steroids / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D013256:Steroids