title: Microchip-based electrochemical detection for monitoring cellular systems.
abstract: The use of microchip devices to study cellular systems is a rapidly growing research area. There are numerous advantages of using on-chip integrated electrodes to monitor various cellular processes. The purpose of this review is to give examples of advancements in microchip-based cellular analysis, specifically where electrochemistry is used for the detection scheme. These examples include on-chip detection of single-cell quantal exocytosis, electrochemical analysis of intracellular contents, the ability to integrate cell culture/immobilization with electrochemistry, and the use of integrated electrodes to ensure cell confluency in longer-term cell culture experiments. A perspective on future trends in this area is also given.
authors: Department of Chemistry, Saint Louis University, St. Louis, MO 63103, USA.
authors: Alicia S
authors: AS
authors: Johnson
authors: Asmira
authors: A
authors: Selimovic
authors: R Scott
authors: RS
authors: Martin
mesh_terms: D000818:Animals; D002477:Cells / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D056656:Lab-On-A-Chip Devices; D046208:Microchip Analytical Procedures / Q000379:methods*