title: Mortality in hypereosinophilic syndrome: 19 years of experience at Mayo Clinic with a review of the literature.
abstract: BACKGROUND
  Information in the literature regarding causes of mortality in patients with hypereosinophilic syndrome (HES) is limited.
  
  
  METHODS
  This was a retrospective review of the morbidities and causes of death in HES patients at Mayo Clinic.
  
  
  RESULTS
  Overall, out of the 247 diagnosed HES patients, 23 died during the 19 years that this review encompassed. The cause of death was identified in 15 patients (65%): cardiac dysfunction in 5 (33%), infection in 3 (20%), unrelated malignancy in 3 (20%), thromboembolic phenomena in 2 (13%), and vascular disease in 2 (13%).
  
  
  CONCLUSIONS
  Targeted monitoring of the at-risk end organs, combined with early treatment, may have the ability to improve survival and reduce morbidity in HES patients.
authors: Division of Allergic Diseases, and the Mayo Clinic Program for Mast Cell and Eosinophil Disorders, Mayo Clinic, Rochester, MN 55905, USA. podjasek.jenna@mayo.edu
authors: Jenna C
authors: JC
authors: Podjasek
authors: Joseph H
authors: JH
authors: Butterfield
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies