title: Palladium-copper-cocatalyzed intramolecular oxidative coupling: an efficient and atom-economical strategy for the synthesis of 3-acylindoles.
abstract: A new and efficient catalytic approach to the synthesis of 3-acylindoles under Pd-Cu-cocatalyzed oxidative conditions is demonstrated. tert-Butyl hydroperoxide (TBHP) acts not only as the oxidant, but also as an oxygen source in the approach. The process allows quick and atom-economical assembly of 3-acylindoles from readily available starting materials and tolerates a broad range of functional groups.
authors: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors: Xiao-Feng
authors: XF
authors: Xia
authors: Lu-Lu
authors: LL
authors: Zhang
authors: Xian-Rong
authors: XR
authors: Song
authors: Yan-Ning
authors: YN
authors: Niu
authors: Xue-Yuan
authors: XY
authors: Liu
authors: Yong-Min
authors: YM
authors: Liang
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D058451:Oxidative Coupling; D010165:Palladium / Q000737:chemistry*
chemical_list: D007211:Indoles; D010165:Palladium; D003300:Copper