title: Highly efficient ionization of phosphopeptides at low pH by desorption electrospray ionization mass spectrometry.
abstract: A fast and novel strategy for efficient ionization of phosphopeptides in mixtures is reported, in which the sample is acidified to low pH to suppress the deprotonation of phosphate groups and then followed by direct analysis using liquid sample desorption electrospray ionization mass spectrometry (DESI-MS).
authors: College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, China, 250014.|Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Ohio University, Athens, OH, USA 45701.
authors: Ning
authors: N
authors: Pan
authors: Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Ohio University, Athens, OH, USA 45701.
authors: Pengyuan
authors: P
authors: Liu
authors: Department of Chemistry, Washington University, St. Louis, MO, USA 63130.
authors: Weidong
authors: W
authors: Cui
authors: College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, China, 250014.
authors: Bo
authors: B
authors: Tang
authors: College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, China, 250014.
authors: Jingmin
authors: J
authors: Shi
authors: Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Ohio University, Athens, OH, USA 45701.
authors: Hao
authors: H
authors: Chen
mesh_terms: D000595:Amino Acid Sequence; D006863:Hydrogen-Ion Concentration; D008969:Molecular Sequence Data; D010748:Phosphopeptides / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000191:economics / Q000379:methods*
chemical_list: D010748:Phosphopeptides