title: Effect of acute cadmium exposure on metal accumulation and oxidative stress biomarkers of Sparus aurata.
abstract: Cadmium (Cd) is a non-essential metal which could be toxic in traces for aquatic species. Increasing Cd concentrations in sea water is mainly related to waste waters provided from growing industrial and agricultural activities. The present study investigated the accumulation of Cd (0.5mg/L) in different tissues of Sparus aurata under a short term exposure (2, 4 and 24h) using the atomic absorption. This work investigated also the impact of the metal on oxidative stress biomarkers and acetyl cholinesterase activity (AchE). Our results showed that Cd accumulation in different tissues depends largely on the length of the exposure period to the metal. Indeed, the highest concentrations were obtained after 24h. Cd accumulation in tissues was in the following order: intestines > liver > gills > dorsal muscle. Cadmium administration increased significantly catalase activity (CAT), glutathione level (GSH) and malondialdehyde production (MDA) after 24h of exposure. In contrast, AchE activity was decreased after the same period of exposure to the metal. There were no significant changes in oxidative stress biomarkers after 2 and 4h of exposure, except for superoxide dismutase (SOD) activity which attained the highest level after 4h. These results suggest that short-term exposure of Sparus aurata to Cd (0.5mg/L) induced an important metal accumulation in intestine and a notable oxidative stress response.
authors: Research Unit Mycotoxines, Phycotoxines and Associated Pathologies, Faculty of Pharmacy, Monastir 5000, Tunisia. souid_tn@yahoo.fr
authors: Ghada
authors: G
authors: Souid
authors: Nouha
authors: N
authors: Souayed
authors: Fatma
authors: F
authors: Yaktiti
authors: Khira
authors: K
authors: Maaroufi
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D002104:Cadmium / Q000378:metabolism / Q000633:toxicity*; D004789:Enzyme Activation / Q000187:drug effects; D005880:Gills / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D021541:Sea Bream / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D008670:Metals; D014874:Water Pollutants, Chemical; D002104:Cadmium; D008315:Malondialdehyde; D000110:Acetylcholinesterase