title: Receptor oligomerization: from early evidence to current understanding in class B GPCRs.
abstract: Dimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization. Class B GPCRs are receptors to a family of hormones including secretin, growth hormone-releasing hormone, vasoactive intestinal polypeptide and parathyroid hormone, among others. The functional implications of receptor dimerization have extensively been studied in class A GPCRs, while less is known regarding its function in class B GPCRs. This article reviews receptor oligomerization in terms of the early evidence and current understanding particularly of class B GPCRs.
authors: Endocrinology, School of Biological Sciences, The University of Hong Kong Hong Kong, China.
authors: Stephanie Y L
authors: SY
authors: Ng
authors: Leo T O
authors: LT
authors: Lee
authors: Billy K C
authors: BK
authors: Chow
keywords: BRET; GPCR; class B; oligomerization; secretin receptor