title: A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.
abstract: This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
authors: University of St Andrews, EaStChem School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife KY16 9ST, UK. qz@st-andrews.ac.uk
authors: Qingzhi
authors: Q
authors: Zhang
authors: Agnieszka
authors: A
authors: Kulczynska
authors: David J
authors: DJ
authors: Webb
authors: Ian L
authors: IL
authors: Megson
authors: Nigel P
authors: NP
authors: Botting
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy; D006146:Guanidines / Q000737:chemistry; D006801:Humans; D006898:Hydroxylamines; D009569:Nitric Oxide / Q000378:metabolism*; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
chemical_list: D006146:Guanidines; D006898:Hydroxylamines; D011355:Prodrugs; D014665:Vasodilator Agents; D009569:Nitric Oxide; C029604:hydroxyguanidine; D005723:gamma-Glutamyltransferase