title: Biocompatibility of intracanal medications based on calcium hydroxide.
abstract: Objective. The aim of this study was to evaluate the rat subcutaneous tissue reaction to calcium hydroxide-based intracanal medicaments, UltraCal XS (calcium hydroxide, barium sulphate, aqueous matrix), Hydropast (calcium hydroxide, barium sulphate, and propyleneglycol), and Calen (Calcium hydroxide, zinc oxide, colophony, and polyethyleneglycol), used as a control. Methods. Forty-eight rats (Rattus Norvegicus Holtzman) were distributed in three groups: Calen, UltraCal XS, and Hydropast. Polyethylene tubes filled with one of the medicaments were implanted in the dorsal subcutaneous. After 7 and 30 days, the implants were removed and the specimens were fixed and embedded in paraffin. Morphological and quantitative analyses were carried out in the HE-stained sections. The numerical density of inflammatory cells in the capsule was evaluated and statistical analyses were performed (P ≤ 0.05). Results. At 7 days, all materials induced an inflammatory reaction in the subcutaneous tissue adjacent to the implants. In all groups, a significant reduction in the number of inflammatory cells and giant cells was verified in the period of 30 days. Conclusion. These results indicate that the calcium hydroxide-based medicaments evaluated present biocompatibility similar to Calen.
authors: Department of Restorative Dentistry, Araraquara Dental School, Universidade Estadual Paulista (UNESP), 14801-903 Araraquara, SP, Brazil.
authors: Carolina
authors: C
authors: Andolfatto
authors: Guilherme Ferreira
authors: GF
authors: da Silva
authors: Ana Livia Gomes
authors: AL
authors: Cornélio
authors: Juliane Maria
authors: JM
authors: Guerreiro-Tanomaru
authors: Mario
authors: M
authors: Tanomaru-Filho
authors: Gisele
authors: G
authors: Faria
authors: Idomeo
authors: I
authors: Bonetti-Filho
authors: Paulo Sérgio
authors: PS
authors: Cerri