title: Morbidity and outcome of severe respiratory syncytial virus infection.
abstract: BACKGROUND
  Respiratory syncytial virus (RSV) is the main cause of severe acute respiratory infection (SARI) in infants and young children. This study aimed to identify risk factors for intensive care unit (ICU) admission, prolonged length of stay (PLOS), and mortality in patients hospitalized with SARI caused by RSV.
  
  
  METHODS
  This prospective cohort study included children hospitalized with SARI (according to the World Health Organization definition) and whose laboratory results proved RSV infection during the period from February 2010 to May 2011.
  
  
  RESULTS
  Out of 240 enrolled patients, 24 patients (10%) were admitted to the ICU, 57 patients (24.3%) had a PLOS of >9 days and 12 patients (5%) died. The presence of cyanosis (P = 0.000; OR, 351.7) and lung consolidation (P = 0.006, OR, 9.3) were independent risk factors associated with ICU admission. The need for ICU admission (P = 0.000; OR, 6.1) and lung consolidation (P = 0.008, OR, 2.46) were independent risk factors associated with PLOS. The presence of an underlying congenital heart disease (P = 0.03, OR, 18.3), thrombocytopenia (P = 0.04, OR, 32.86) and mechanical ventilation (P = 0.000; OR, 449.4) were the only independent risk factors associated with mortality in our study.
  
  
  CONCLUSIONS
  Early recognition of risk factors for complicated RSV disease on admission prompts early interventions and early ICU admissions for these children.
authors: Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt.
authors: Amani A
authors: AA
authors: El Kholy
authors: Nadia A
authors: NA
authors: Mostafa
authors: Seham A
authors: SA
authors: El-Sherbini
authors: Aliaa A
authors: AA
authors: Ali
authors: Reem I
authors: RI
authors: Ismail
authors: Rania I
authors: RI
authors: Magdy
authors: Mona S
authors: MS
authors: Hamdy
authors: May S
authors: MS
authors: Soliman
mesh_terms: D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004534:Egypt; D005260:Female; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D007902:Length of Stay; D008297:Male; D010343:Patient Admission; D011446:Prospective Studies; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis* / Q000401:mortality; D012307:Risk Factors; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis* / Q000401:mortality; D016019:Survival Analysis