title: Octreotide-induced hepatitis in a child with persistent hyperinsulinemia hypoglycemia of infancy.
abstract: Persistent hyperinsulinemic hypoglycemia of infancy (PHHI), the most common cause of persistent hypoglycemia in the neonatal period and infancy, is a genetic disorder characterized by abnormal regulation of insulin secretion. Octreotide, a somatostatin analog, is often used as a second-line treatment when diazoxide therapy fails to control hypoglycemia. We report herein a rare development of octreotide-induced hepatitis following prolonged treatment for PHHI in an infant. Octreotide-induced hepatitis may occur mostly when high doses are given, or when dosing is increased. This warrants routine examination of liver function. When hepatitis develops, prompt cessation of octreotide therapy will probably result in subsequent resolution.
authors: Department of Pediatric, Tel-Aviv University, Israel.
authors: Josef
authors: J
authors: Ben-Ari
authors: Meidad
authors: M
authors: Greenberg
authors: Dan
authors: D
authors: Nemet
authors: Evgeny
authors: E
authors: Edelstein
authors: Alon
authors: A
authors: Eliakim
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000175:diagnosis*; D044903:Congenital Hyperinsulinism / Q000150:complications / Q000188:drug therapy*; D004351:Drug Resistance; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008111:Liver Function Tests; D008297:Male; D015282:Octreotide / Q000009:adverse effects* / Q000627:therapeutic use*
chemical_list: D005765:Gastrointestinal Agents; D015282:Octreotide