title: [Optimization of the extraction process for qingrejiedu oral liquid with synthesizing multiple guidelines grading method].
abstract: OBJECTIVE
  To optimize the extraction process for Qingrejiedu oral liquid with synthesizing multiple guidelines grading method.
  
  
  METHODS
  Used the extraction rate of baicalin and geniposide comprehensive contribution rate variance as index, extraction time and added water were as factors, central composite design was used for optimization of extraction process, and forecasting analysis parameters.
  
  
  RESULTS
  The optimal extraction process was as follows: extraction time 139 min, added water 13 times, grading index was 0.768.
  
  
  CONCLUSIONS
  Synthesizing multiple guidelines grading method is ideal for multi-component extraction experiment design, its easy application, the forecast is good and so on.
authors: The 152th Central Hospital of PLA, Pingdingshan 467000, China.
authors: Hong
authors: H
authors: Liu
authors: Zhen-Wei
authors: ZW
authors: Zhang
authors: Zhi-Qiang
authors: ZQ
authors: Ji
mesh_terms: D000284:Administration, Oral; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D005419:Flavonoids / Q000032:analysis / Q000302:isolation & purification*; D032062:Gardenia / Q000737:chemistry; D039823:Iridoids / Q000032:analysis / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000737:chemistry*; D011786:Quality Control; D015203:Reproducibility of Results; D031364:Scutellaria baicalensis / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000592:standards
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D039823:Iridoids; C007835:geniposide; C038044:baicalin