title: Sulfatide attenuates experimental Staphylococcus aureus sepsis through a CD1d-dependent pathway.
abstract: Natural killer T (NKT) lymphocytes are implicated in the early response to microbial infection. Further, sulfatide, a myelin self-glycosphingolipid, activates a type II NKT cell subset and can modulate disease in murine models. We examined the role of NKT cells and the effect of sulfatide treatment in a murine model of Staphylococcus aureus sepsis. The lack of CD1d-restricted NKT cells did not alter survival after a lethal inoculum of S. aureus. In contrast, sulfatide treatment significantly improved the survival rate of mice with S. aureus sepsis, accompanied by decreased levels of tumor necrosis factor alpha and interleukin-6 in the blood. The protective effect of sulfatide treatment depended on CD1d but not on type I NKT cells, suggesting that activation of type II NKT cells by sulfatide has beneficial effects on the outcome of S. aureus sepsis in this model.
authors: Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors: Jakub
authors: J
authors: Kwiecinski
authors: Sara
authors: S
authors: Rhost
authors: Linda
authors: L
authors: Löfbom
authors: Maria
authors: M
authors: Blomqvist
authors: Jan Eric
authors: JE
authors: Månsson
authors: Susanna L
authors: SL
authors: Cardell
authors: Tao
authors: T
authors: Jin
mesh_terms: D000818:Animals; D055610:Antigens, CD1d / Q000378:metabolism*; D005260:Female; D007155:Immunologic Factors / Q000008:administration & dosage*; D015850:Interleukin-6 / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000276:immunology* / Q000472:pathogenicity; D013433:Sulfoglycosphingolipids / Q000008:administration & dosage*; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D055610:Antigens, CD1d; C526879:Cd1d1 protein, mouse; D007155:Immunologic Factors; D015850:Interleukin-6; D013433:Sulfoglycosphingolipids; D014409:Tumor Necrosis Factor-alpha