title: Microbiology and epidemiology of oral yeast colonization in hemopoietic progenitor cell transplant recipients.
abstract: OBJECTIVE
  We monitored the epidemiology and microbiology of oral yeast colonization in patients undergoing hemopoietic progenitor cell transplantation (HPCT) to examine associations between yeast colonization and oral mucositis.
  
  
  METHODS
  One hundred twenty-one consecutive HPCT patients were sampled for oral yeasts prior to fluconazole (FLC) prophylaxis, at transplantation, and weekly until discharge. Clinical oral mucositis screenings were performed triweekly.
  
  
  RESULTS
  Yeast colonization was evident at 216 of 510 total visits. Candida albicans and Candida glabrata were the predominant organisms. Eight patients showed elevated minimal inhibitory concentrations to FLC. One patient developed fungal septicemia. Patients with oral mucositis assessment scale scores <20 had higher colonization rates than those with higher scores.
  
  
  CONCLUSIONS
  FLC is effective in controlling a variety of oral yeasts in HPCT recipients. FLC-resistant yeasts do emerge and can be the source of fungal sepsis. A positive association was not shown between yeast colonization and the presence or severity of oral mucositis.
authors: Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-390, USA. westbrooks@uthscsa.edu
authors: Steven D
authors: SD
authors: Westbrook
authors: William R
authors: WR
authors: Kirkpatrick
authors: Nathan P
authors: NP
authors: Wiederhold
authors: Cesar O
authors: CO
authors: Freytes
authors: Juan J
authors: JJ
authors: Toro
authors: Thomas F
authors: TF
authors: Patterson
authors: Spencer W
authors: SW
authors: Redding
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002175:Candida / Q000145:classification / Q000302:isolation & purification*; D002176:Candida albicans / Q000302:isolation & purification; D041221:Candida glabrata / Q000302:isolation & purification; D041022:Candida tropicalis / Q000145:classification; D002180:Candidiasis, Oral / Q000517:prevention & control; D018890:Chemoprevention; D015331:Cohort Studies; D025141:Drug Resistance, Fungal; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D005500:Follow-Up Studies; D016469:Fungemia / Q000209:etiology; D019337:Hematologic Neoplasms / Q000601:surgery; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology*; D011446:Prospective Studies; D012441:Saccharomyces cerevisiae / Q000302:isolation & purification; D013280:Stomatitis / Q000382:microbiology; D019172:Transplantation Conditioning / Q000379:methods; D055815:Young Adult
chemical_list: D015725:Fluconazole