title: Histological complete response after neoadjuvant XELOX in advanced gastric carcinoma.
abstract: We report on a case of a 65-year-old Chinese male with locally advanced gastric adenocarcinoma achieving pathological complete response after neoadjuvant chemotherapy with capecitabine and oxaliplatin (XELOX) regimen. He underwent esophagogastroduodenoscopy, which revealed a 6x5cm gastric ulcer. Biopsy of gastric ulcer revealed adenocarcinoma. Further workups with abdominal enhancement computed tomography (CT) staged his cancer as T4N2M0. He received 2 cycles of neoadjuvant chemotherapy with XELOX without severe toxicity. Afterwards, he underwent curative surgery consisting of total gastrectomy with extended D2 lymph node dissections and a Roux-en-Y esophagojejunostomy. On microscopic examination, no tumor cells were detected in the ulcer scar of the resected stomach and in the regional lymph nodes. The benefit of XELOX regimen as neoadjuvant chemotherapy in gastric cancer is worth further investigation.
authors: Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors: Qun
authors: Q
authors: Zhao
authors: Yong
authors: Y
authors: Li
authors: Yuan
authors: Y
authors: Tian
authors: Yan-Ning
authors: YN
authors: Chen
authors: Bi-Bo
authors: BB
authors: Tan
authors: Xüe-Feng
authors: XF
authors: Zhao
authors: Zhi-Kai
authors: ZK
authors: Jiao
authors: Zhi-Dong
authors: ZD
authors: Zhang
authors: Sheng-Li
authors: SL
authors: Chang
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000368:Aged; D000713:Anastomosis, Roux-en-Y; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001706:Biopsy; D000069287:Capecitabine; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D016145:Endoscopy, Digestive System; D004946:Esophagostomy; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010071:Oxaloacetates; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D010071:Oxaloacetates; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil