title: Endometrial ablation for the treatment of heavy menstrual bleeding in obese women.
abstract: OBJECTIVE
  To compare the efficacy and safety of endometrial ablation (EA) among obese versus non-obese women.
  
  
  METHODS
  A retrospective cohort study of 666 women who underwent EA at the Mayo Clinic, Rochester, USA, between January 1, 1998, and December 31, 2005, was conducted. Obesity was defined as a body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters) of 30 or above. Outcome measures included treatment failure and amenorrhea. Regression models were used to compare outcomes and adjust for known confounders.
  
  
  RESULTS
  The mean BMI was 29.6±7.7; 263 women (39.5%) were classified as obese. No difference was observed in treatment failure at 5 years between the obese and non-obese cohorts (11.6% vs 9.7%) with an adjusted hazard ratio of 0.96 (95% confidence interval [CI], 0.60-1.53; P=0.878). The crude 12-month amenorrhea rate was higher among non-obese than obese women (24.3% vs 17.5%); however, this difference was not significant after adjusting for known predictors of amenorrhea. The odds ratio was 1.28 (95% CI, 0.75-2.19; P=0.366). Adverse events were rare and comparable between the cohorts.
  
  
  CONCLUSIONS
  The use of EA is a safe and effective option for women with obesity.
authors: Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905, USA.
authors: Annetta M
authors: AM
authors: Madsen
authors: Sherif A
authors: SA
authors: El-Nashar
authors: Matthew R
authors: MR
authors: Hopkins
authors: Zaraq
authors: Z
authors: Khan
authors: Abimbola O
authors: AO
authors: Famuyide
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000453:epidemiology / Q000209:etiology*; D015331:Cohort Studies; D055356:Endometrial Ablation Techniques / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008595:Menorrhagia / Q000601:surgery*; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D016896:Treatment Outcome