title: The fetal inflammatory response in subgroups of women with preterm prelabor rupture of the membranes.
abstract: OBJECTIVE
  To evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on the intensity of the fetal inflammatory response and the occurrence of fetal inflammatory response syndrome (FIRS) in preterm prelabor rupture of membranes (PPROM).
  
  
  METHODS
  One hundred and forty-nine women with singleton pregnancies complicated by PPROM between the gestational ages 24 + 0 and 36 + 6 weeks were included in the study. Blood samples were obtained by venipuncture from the umbilical cord after the delivery of the newborn. The umbilical cord blood interleukin (IL)-6 levels were evaluated using ELISA kits. The fetal inflammatory response was determined by IL-6 levels, and FIRS was defined as an umbilical cord blood IL-6 >11 pg/mL.
  
  
  RESULTS
  IL-6 levels and the occurrence of FIRS were higher in women complicated with both MIAC and HCA (median IL-6 35.5 pg/mL, FIRS in 68%) than in women with HCA alone (median IL-6 5.8 pg/mL, FIRS in 36%), MIAC alone (median IL-6 2.8 pg/mL, FIRS in 17%) or women without MIAC or HCA (median IL-6 4.3 pg/mL, FIRS in 29%). There were no differences in IL-6 levels or rates of FIRS among women with MIAC alone or HCA alone and women without both MIAC and HCA.
  
  
  CONCLUSIONS
  A higher fetal inflammatory response mediated by umbilical cord blood IL-6 was identified when both MIAC and HCA were detected in pregnancies complicated by PPROM.
authors: Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. kacermar@fnhk.cz
authors: Marian
authors: M
authors: Kacerovsky
authors: Teresa
authors: T
authors: Cobo
authors: Ctirad
authors: C
authors: Andrys
authors: Ivana
authors: I
authors: Musilova
authors: Marcela
authors: M
authors: Drahosova
authors: Helena
authors: H
authors: Hornychova
authors: Petr
authors: P
authors: Janku
authors: Bo
authors: B
authors: Jacobsson
mesh_terms: D000293:Adolescent; D000328:Adult; D002821:Chorioamnionitis / Q000473:pathology* / Q000503:physiopathology*; D005321:Extraembryonic Membranes / Q000473:pathology; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005322:Premature Rupture of Fetal Membranes / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology; D005333:Fetus / Q000473:pathology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D011247:Pregnancy; D055815:Young Adult
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6