title: A novel synthesis of 1-aryl-3-piperidone derivatives.
abstract: A novel method to construct the 1-aryl-3-piperidone scaffold is described here. Starting from 3,5-dichloroaniline, a seven-step synthesis, without the use of protecting groups, generates the desired 3-piperidone ring in an overall yield of 30% through a key Morita-Baylis-Hillman reaction and ring-closing metathesis, providing easy access to diverse and useful heterocycles.
authors: Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Design, Northwestern University, Evanston, Illinois 60208-3113 USA.
authors: Yinan
authors: Y
authors: Zhang
authors: Richard B
authors: RB
authors: Silverman