title: Different sizes of centrilobular ground-glass opacities in chest high-resolution computed tomography of patients with pulmonary veno-occlusive disease and patients with pulmonary capillary hemangiomatosis.
abstract: BACKGROUND
  Centrilobular ground-glass opacity (GGO) is one of the characteristic findings in chest high-resolution computed tomography (HRCT) of patients with pulmonary veno-occlusive disease (PVOD) and patients with pulmonary capillary hemangiomatosis (PCH). However, clinical differential diagnosis of these two diseases is difficult and has not been established. In order to clarify their differences, we compared the sizes of GGOs in chest HRCT and the sizes of capillary assemblies in pulmonary vascular casts between patients diagnosed pathologically with PVOD and PCH.
  
  
  METHODS
  We evaluated chest HRCT images for four patients with idiopathic pulmonary arterial hypertension (IPAH), three patients with PVOD and three patients with PCH, and we evaluated pulmonary vascular casts of lung tissues obtained from those patients at lung transplantation or autopsy.
  
  
  RESULTS
  Centrilobular GGOs in chest HRCT were observed in patients with PVOD and patients with PCH but not in patients with IPAH. We measured the longest diameter of the GGOs. The size of centrilobular GGOs was significantly larger in patients with PCH than in patients with PVOD (5.60±1.43 mm versus 2.51±0.79 mm, P<.01). We succeeded in visualization of the 3-dimensional structures of pulmonary capillary vessels obtained from the same patients with PVOD and PCH undergoing lung transplantation or autopsy and measured the diameters of capillary assemblies. The longest diameter of capillary assemblies was also significantly larger in patients with PCH than in patients with PVOD (5.44±1.71 mm versus 3.07±1.07 mm, P<.01).
  
  
  CONCLUSIONS
  Measurement of the sizes of centrilobular GGOs in HRCT is a simple and useful method for clinical differential diagnosis of PVOD and PCH.
authors: Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Aya
authors: A
authors: Miura
authors: Satoshi
authors: S
authors: Akagi
authors: Kazufumi
authors: K
authors: Nakamura
authors: Keiko
authors: K
authors: Ohta-Ogo
authors: Katsushi
authors: K
authors: Hashimoto
authors: Satoshi
authors: S
authors: Nagase
authors: Kunihisa
authors: K
authors: Kohno
authors: Kengo
authors: K
authors: Kusano
authors: Aiko
authors: A
authors: Ogawa
authors: Hiromi
authors: H
authors: Matsubara
authors: Shinichi
authors: S
authors: Toyooka
authors: Takahiro
authors: T
authors: Oto
authors: Aiji
authors: A
authors: Ohtsuka
authors: Tohru
authors: T
authors: Ohe
authors: Hiroshi
authors: H
authors: Ito
mesh_terms: D000293:Adolescent; D000328:Adult; D001344:Autopsy; D002196:Capillaries / Q000000981:diagnostic imaging* / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D065627:Familial Primary Pulmonary Hypertension; D005260:Female; D018324:Hemangioma, Capillary / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D016040:Lung Transplantation; D008297:Male; D011237:Predictive Value of Tests; D011668:Pulmonary Veno-Occlusive Disease / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D011857:Radiographic Image Interpretation, Computer-Assisted; D016628:Replica Techniques; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: Centrilobular ground-glass opacity; Computed tomography; Pulmonary capillary hemangiomatosis; Pulmonary hypertension; Pulmonary veno-occlusive disease