title: Sesquiterpenoids from Chloranthus multistachys.
abstract: An 8,9-seco-lindenane disesquiterpenoid, chloramultiol G, four eudesmane sesquiterpenoids, ent-(3R)-3-hydroxyatractylenolide III and multistalactones A-C, and four guaiane sesquiterpenoids, (1R,4S,5R,8S,10S)-zedoalactone A and multistalactones D-F, along with 14 known compounds, were isolated from whole plant tissues of Chloranthus multistachys. Their structures were established by extensive NMR experiments in conjunction with mass spectrometry. Except for chloramultiol G, the absolute stereochemistries of the other eight were confirmed by single-crystal X-ray crystallography and CD spectra. Nine compounds were tested for cytotoxicity against five human tumor cell lines and for antifungal activity against four microorganisms in vitro, but all were inactive.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. haiyangliu@mail.kib.ac.cn
authors: Hai-Yang
authors: HY
authors: Liu
authors: Xin-Hui
authors: XH
authors: Ran
authors: Ning-Bo
authors: NB
authors: Gong
authors: Wei
authors: W
authors: Ni
authors: Xu-Jie
authors: XJ
authors: Qin
authors: Yan-Yan
authors: YY
authors: Hou
authors: Yang
authors: Y
authors: Lü
authors: Chang-Xiang
authors: CX
authors: Chen
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002681:China; D018360:Crystallography, X-Ray; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D018514:Plant Structures / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D013729:Terpenes