title: [Current progress in lipoprotein lipase and atherosclerosis].
abstract: Lipoprotein lipase (LPL) which is the rate-limiting enzyme for the hydrolysis of the triglyceride (TG) core of circulating TG-rich lipoproteins, chylomicrons, low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL) play an important role in reducing TG deposition in vivo. Recent advances indicate that LPL gene structure, synthesis, secretion and degradation had complexity, and it is regulated by many transcription factors, miRNA, interactive proteins and hormonal. Its role in atherosclerosis in the current studies is still controversial. So we focus the LPL on the structure, synthesis and degradation, function, regulation and contribution to atherosclerosis to clarify its role in cardiovascular disease (CVD).
authors: Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang 421001, China.
authors: Guo-Ping
authors: GP
authors: Tian
authors: Wu-Jun
authors: WJ
authors: Chen
authors: Ping-Ping
authors: PP
authors: He
authors: Wei-Dong
authors: WD
authors: Yin
authors: Chao-Ke
authors: CK
authors: Tnag
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology*; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D014280:Triglycerides; D008071:Lipoprotein Lipase