title: Radiolytic transformation of rotenone with potential anti-adipogenic activity.
abstract: Radiolytic transformation of the isoflavonoid rotenone (1) with γ-irradiation afforded two new degraded products, rotenoisins A (2) and (3). The structures of the two new rotenone derivatives were elucidated on the basis of spectroscopic methods. The new products 2 and 3 exhibited significantly enhanced inhibitory activities against pancreatic lipase and adipocyte differentiation in 3T3-L1 cells when compared to parent rotenone.
authors: Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea.
authors: Chul-Hong
authors: CH
authors: Park
authors: Byung Yeoup
authors: BY
authors: Chung
authors: Seung Sik
authors: SS
authors: Lee
authors: Hyoung-Woo
authors: HW
authors: Bai
authors: Jae Young
authors: JY
authors: Cho
authors: Cheorun
authors: C
authors: Jo
authors: Tae Hoon
authors: TH
authors: Kim
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects*; D050156:Adipogenesis / Q000187:drug effects; D000818:Animals; D008049:Lipase / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D011675:Pulse Radiolysis; D012402:Rotenone / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology* / Q000528:radiation effects; D013329:Structure-Activity Relationship
chemical_list: D012402:Rotenone; D008049:Lipase