title: Resveratrol prevents global cerebral ischemia-induced decrease in lipid content.
abstract: OBJECTIVE
  The present study was undertaken to evaluate whether resveratrol (RSV) modulates membrane lipid composition, as well as on ganglioside profile in ischemia/reperfusion injury.
  
  
  METHODS
  Global cerebral ischemia was induced by four-vessel occlusion for 10 minutes.  RSV (30 mg/kg) or vehicle was intraperitoneally administered to rats 7 days prior to ischemia. Brain structures were homogenized with chloroform/methanol for ganglioside, phospholipids, and cholesterol levels.
  
  
  RESULTS
  RSV significantly prevented the reduction in the total content  of gangliosides, phospholipids, and cholesterol in hippocampi and cerebral cortex induced by global cerebral ischemia. Although ischemia/reperfusion decreased ganglioside content, the ganglioside profiles were apparently not modified.
  
  
  CONCLUSIONS
  Our experiments suggest that lipid  metabolism is important for development of ischemic damage and indicate that RSV treatment 7 days prior to ischemia may prevent membrane lipid loss.
authors: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, UFRGS, Porto Alegre, RS, Brazil. simaof@gmail.com
authors: Fabrício
authors: F
authors: Simão
authors: Aline
authors: A
authors: Matté
authors: Ana Carolina
authors: AC
authors: Breier
authors: Fernando
authors: F
authors: Kreutz
authors: Vera Maria Treis
authors: VM
authors: Trindade
authors: Carlos Alexandre
authors: CA
authors: Netto
authors: Christianne G
authors: CG
authors: Salbego
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000150:complications* / Q000188:drug therapy*; D002784:Cholesterol / Q000378:metabolism; D002855:Chromatography, Thin Layer; D004195:Disease Models, Animal; D005733:Gangliosidoses / Q000378:metabolism; D052439:Lipid Metabolism Disorders / Q000209:etiology* / Q000517:prevention & control*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D010743:Phospholipids; D013267:Stilbenes; D002784:Cholesterol; D000077185:Resveratrol