title: Real-time size discrimination and elemental analysis of gold nanoparticles using ES-DMA coupled to ICP-MS.
abstract: We report the development of a hyphenated instrument with the capacity to quantitatively characterize aqueous suspended gold nanoparticles (AuNPs) based on a combination of gas-phase size separation, particle counting, and elemental analysis. A customized electrospray-differential mobility analyzer (ES-DMA) was used to achieve real-time upstream size discrimination. A condensation particle counter and inductively coupled plasma mass spectrometer (ICP-MS) were employed as downstream detectors, providing information on number density and elemental composition, respectively, of aerosolized AuNPs versus the upstream size selected by ES-DMA. A gas-exchange device was designed and optimized to improve the conversion of air flow (from the electrospray) to argon flow required to sustain the ICP-MS plasma, the key compatibility issue for instrumental hyphenation. Our work provides the proof of concept and a working prototype for utilizing this construct to successfully measure (1) number- and mass-based distributions; (2) elemental compositions of nanoparticles classified by size, where the size classification and elemental analysis are performed within a single experiment; (3) particle concentrations in both solution (before size discrimination) and aerosol (after size discrimination) phases; and (4) the number of atoms per nanoparticle or the nanoparticle density.
authors: Materials Measurement Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
authors: Sherrie
authors: S
authors: Elzey
authors: De-Hao
authors: DH
authors: Tsai
authors: Lee L
authors: LL
authors: Yu
authors: Michael R
authors: MR
authors: Winchester
authors: Michael E
authors: ME
authors: Kelley
authors: Vincent A
authors: VA
authors: Hackley