title: The discordance between primary breast cancer lesions and pulmonary metastatic lesions in expression of aldehyde dehydrogenase 1-positive cancer cells.
abstract: BACKGROUND
  We evaluated the expression of aldehyde dehydrogenase 1 (ALDH1) between primary breast lesions and pulmonary metastatic (PM) lesions in breast cancer patients.
  
  
  METHODS
  We retrospectively analyzed the clinicopathological features and the expression statuses of ER, PR, HER2, Ki-67 and ALDH-1 in both primary and metastatic breast cancer lesions and evaluated the discordance rates in the expressions of these markers between the primary and metastatic lesions, and also the prognostic value of these factors.
  
  
  RESULTS
  None of the PM patients had metastases at any other sites, and all had undergone curative breast cancer surgery. The pulmonary operation was partial resection in 15 (88 %) patients and lobectomy in 2 (12 %) patients. The median overall survival (OS) after resection of the PNs (OS) was 48 months. The discordance rates in the expressions of ER, PR, HER2, Ki67 and ALDH-1 between the primary and metastatic lesions were 0, 29, 21, 43 and 50 %, respectively.
  
  
  CONCLUSIONS
  There was significant discordance in the biomarkers between the primary tumors and the metastatic lesions.
authors: Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan, imagon12000@yahoo.co.jp.
authors: Tomohiro
authors: T
authors: Nogami
authors: Tadahiko
authors: T
authors: Shien
authors: Takehiro
authors: T
authors: Tanaka
authors: Hiroyoshi
authors: H
authors: Doihara
authors: Naruto
authors: N
authors: Taira
authors: Daisuke
authors: D
authors: Takabatake
authors: Rieko
authors: R
authors: Nishimura
authors: Keiko
authors: K
authors: Nishiyama
authors: Taeko
authors: T
authors: Mizoo
authors: Shozo
authors: S
authors: Ohsumi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000080924:Aldehyde Dehydrogenase 1 Family; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008175:Lung Neoplasms / Q000201:enzymology / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D050697:Retinal Dehydrogenase / Q000378:metabolism*; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D000080924:Aldehyde Dehydrogenase 1 Family; D014408:Biomarkers, Tumor; D007527:Isoenzymes; D018719:Erb-b2 Receptor Tyrosine Kinases; D011980:Receptors, Progesterone; D050697:Retinal Dehydrogenase; C510223:ALDH1A1 protein, human; C508053:ERBB2 protein, human