title: Spontaneous puberty in girls with early diagnosis of Turner syndrome.
abstract: OBJECTIVE
  To verify if the frequency of spontaneous pubertal development among girls with Turner syndrome (TS) diagnosed in infancy and childhood is greater than that of patients diagnosed later.
  
  
  METHODS
  Thirty three girls aged < 10 years at the time of diagnosis were evaluated regarding pubertal development. The frequency of spontaneous puberty was compared with that of girls aged > 13 years diagnosed at the same service.
  
  
  RESULTS
  Sixteen of 32 informative patients had signs of spontaneous puberty, a frequency greater than that of patients diagnosed later. In six patients, there was no progression of puberty; menarche occurred in six, and one became pregnant, but the fetus was a stillborn. Spontaneous puberty was absent in all cases with 45,X karyotype.
  
  
  CONCLUSIONS
  The greater prevalence of spontaneous puberty in girls whose diagnosis was not based on pubertal delay suggests that, among those diagnosed later, there is a bias towards patients with hypogonadism.
authors: Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors: Stela
authors: S
authors: Carpini
authors: Annelise Barreto
authors: AB
authors: Carvalho
authors: Gil
authors: G
authors: Guerra-Júnior
authors: Maria Tereza Matias
authors: MT
authors: Baptista
authors: Sofia Helena Valente
authors: SH
authors: Lemos-Marini
authors: Andréa Trevas
authors: AT
authors: Maciel-Guerra
mesh_terms: D000293:Adolescent; D002648:Child; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis; D059785:Karyotype; D011627:Puberty / Q000235:genetics / Q000502:physiology*; D014424:Turner Syndrome / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*