title: Does plasma HDL-C concentration interact with whole-body cholesterol metabolism?
abstract: This review examines the interactions between plasma high density lipoprotein (HDL) metabolism and whole-body cholesterol economy. More specifically, this review addresses three questions: 1) does plasma HDL-C concentration correlate with the parameters of whole-body cholesterol metabolism? 2) Do variations in cholesterol metabolism interfere with plasma HDL-C concentrations? 3) Are the markers of cholesterol synthesis and intestinal absorption specifically under the control of plasma HDL? The following answers were provided to each question, respectively: 1) plasma HDL influences whole-body cholesterol synthesis rate but the evidence that HDL modifies the total amount of cholesterol absorbed by the intestine is not clearly supported by present investigations; 2) there are suggestions that changes in whole body cholesterol metabolism rates do not interfere with plasma HDL-C concentrations; 3) markers of cholesterol synthesis and absorption may specifically be controlled by plasma HDL-C concentrations regarding the genetic causes of extremely low HDL-C concentrations, although within the general population plasma HDL-C concentration is likely ascribed to insulin resistance or diabetes mellitus.
authors: Lipids Laboratory (LIM-10), Endocrinology and Metabolism Division of Hospital das Clinicas, Faculty of Medical Sciences, University of Sao Paulo, Av. Dr. Arnaldo 455, Room 3305, 01246-000 São Paulo, SP, Brazil.
authors: C C
authors: CC
authors: Leança
authors: V S
authors: VS
authors: Nunes
authors: E R
authors: ER
authors: Nakandakare
authors: E C
authors: EC
authors: de Faria
authors: E C R
authors: EC
authors: Quintao
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000096:biosynthesis / Q000097:blood*; D002791:Cholesterol, Dietary / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance; D007408:Intestinal Absorption; D007700:Kinetics; D050356:Lipid Metabolism / Q000187:drug effects
chemical_list: D000924:Anticholesteremic Agents; D015415:Biomarkers; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D002784:Cholesterol