title: Wakayama symposium: new therapies for modulation of epithelialization in corneal wound healing.
abstract: Many factors are involved in the corneal wound healing mechanism, including adhesion, migration, and proliferation of corneal epithelial cells. Abnormal corneal wound healing leads to corneal edema, neovascularization, scar formation, and poor vision. Three agents, 17β-estradiol, nicergoline, and β-glucan, have demonstrated positive effects on the wound healing response in laboratory experiments and may be of help in controlling wound healing in corneas that have suffered epithelial damage or have undergone refractive surgery.
authors: Department of Ophthalmology and Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Jun-Sub
authors: JS
authors: Choi
authors: Choun-Ki
authors: CK
authors: Joo
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000378:metabolism; D019573:Epithelium, Corneal / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology*; D006801:Humans; D009530:Nicergoline / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*; D047071:beta-Glucans / Q000494:pharmacology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D004967:Estrogens; D047071:beta-Glucans; D004958:Estradiol; D009530:Nicergoline