title: Retinal nerve fiber layer and ganglion cell layer thickness in patients receiving systemic isotretinoin therapy.
abstract: To evaluate the effect of oral isotretinoin therapy on retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness by spectral domain optical coherence tomography (OCT). This prospective study included newly diagnosed nodulocystic acne patients about to receive isotretinoin treatment. Macular average GCL thickness and peripapillary average, temporal, nasal, inferior, and superior quadrant RNFL thickness were measured by OCT before and after isotretinoin treatment. Pre- and post-treatment measurements were compared with paired t test. Fifty-six eyes of 28 patients were included. The mean duration of the treatment was 6.5 ± 1.3 months. The mean average GCL thickness was 90.04 ± 5.87 (80-96) μm at baseline and 90.75 ± 6.34 (81-96) μm after treatment. The mean average RNFL thickness was 93.25 ± 6.06 μm (84-107) before treatment and 93.05 ± 5.54 μm (82-106) after treatment. There were no statistically significant differences between pre- and post-treatment values (all p > 0.05). A 6-month course of systemic isotretinoin therapy seems to have no unfavorable effect on retinal ganglion cells; however, larger studies with longer follow-up periods are needed to be conclusive.
authors: Department of Ophthalmology, Recep Tayyip Erdogan University Medical School, Rize, Turkey, bsekeryapan@yahoo.com.
authors: Berrak
authors: B
authors: Sekeryapan
authors: Nursel
authors: N
authors: Dılek
authors: Veysi
authors: V
authors: Oner
authors: Kemal
authors: K
authors: Turkyılmaz
authors: Mehmet Gokhan
authors: MG
authors: Aslan
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003879:Dermatologic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects*; D011446:Prospective Studies; D012164:Retinal Diseases / Q000139:chemically induced*; D012165:Retinal Ganglion Cells / Q000187:drug effects*; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin