title: Prenatal and developmental effect of high molecular weight chitosan (HMWCS) to mice.
abstract: High molecular weight chitosan (HMWCS) is effective at hemostasis and wound healing, and will be potentially used on injured internal organs. To study its prenatal and developmental effect in vivo, forty-four ICR pregnant mice per group were singly injected intraperitoneally at 0, 125, 500 or 2000 mg/kg body weight, respectively, on gestation day 6 (GD6). Clinical signs, reproductive capacity, fetus and infant developments, and histopathological changes were then observed. The results showed that the treatment of HMWCS could decrease body weights and food consumptions, and induce diarrhea, vaginal bleeding, and some other adverse effects in F0 mice. For the emaciation and threatened abortion of pregnant mice, the numbers of live fetuses and early resorption were reduced significantly in HMWCS groups. However, the developments of F1 and F2 mice were not affected, except for lower weights of the body and some organs. In addition, the NOAEL of HMWCS in maternal toxicity was considered to be less than 125 mg/kg, and the NOAEL in developmental toxicity was 125 mg/kg.
authors: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, PR China.
authors: Qinyuan
authors: Q
authors: Cheng
authors: Jiali
authors: J
authors: Zhang
authors: Wenshui
authors: W
authors: Xia
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry / Q000145:classification / Q000633:toxicity*; D003967:Diarrhea / Q000139:chemically induced; D004435:Eating / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects*; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D006490:Hemostatics / Q000737:chemistry / Q000145:classification / Q000633:toxicity*; D018811:Maternal Exposure; D051379:Mice; D008813:Mice, Inbred ICR; D008970:Molecular Weight; D011247:Pregnancy; D013723:Teratogens / Q000737:chemistry / Q000145:classification / Q000633:toxicity*
chemical_list: D006490:Hemostatics; D013723:Teratogens; D048271:Chitosan