title: siRNA therapeutics in the treatment of diseases.
abstract: siRNAs are a class of dsRNAs, 21-23 nucleotides in length, which are able to silence their target genes through enzymatic cleavage of target mRNA. The sequence-specific gene-silencing by siRNA can be used as a new therapeutic approach for treatment of a variety of diseases that are incurable by conventional drugs. Many efforts have been made to overcome the problems related to delivery, stability, off-target gene silencing and immunostimulatory effects of siRNA. Different studies have carried out done to improve in vitro and in vivo delivery of naked or formulated siRNAs. In this review, different aspects of using siRNA as a new class of drugs will be discussed.
authors: Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. basati-gh@medilam.ac.ir
authors: Salar
authors: S
authors: Bakhtiyari
authors: Karimeh
authors: K
authors: Haghani
authors: Gholam
authors: G
authors: Basati
authors: Mohammad Hassan
authors: MH
authors: Karimfar
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D020868:Gene Silencing; D018014:Gene Transfer Techniques; D006801:Humans; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000276:Adjuvants, Immunologic; D034741:RNA, Small Interfering