title: [Analysis of functional properties of biologically active substances using eukaryotic cell models (review)].
abstract: This work presents an analysis of current data on the investigation into the functional properties of biologically active substances in model systems based on cultivated human cells. The knowledge regarding the practical application of cell cultures for the analysis of functional properties of bioactive substances is summarized, including antioxidant, immunomodulating, pro- and prebiotics, and chemoprevention properties. The most promising directions in cell culture model development for the investigation of functional properties, including three-dimensional models, are discussed.
authors: K V
authors: KV
authors: Lisitskaia
authors: I V
authors: IV
authors: Nikolaev
authors: A A
authors: AA
authors: Torkova
authors: V O
authors: VO
authors: Popov
authors: O V
authors: OV
authors: Koroleva
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D001688:Biological Products / Q000494:pharmacology*; D018929:Cell Culture Techniques; D002478:Cells, Cultured; D002853:Chromatography, Liquid; D005057:Eukaryotic Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D005456:Fluorescent Dyes; D005609:Free Radicals / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology; D008954:Models, Biological; D056692:Prebiotics / Q000032:analysis; D019936:Probiotics / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D001688:Biological Products; D005456:Fluorescent Dyes; D005609:Free Radicals; D007155:Immunologic Factors; D056692:Prebiotics