title: Active modification of host inflammation by Salmonella.
abstract: The dampening of host immune responses is a critical aspect of pathogenesis for the enteropathogen Salmonella enterica. Our laboratory has recently described a role for the secreted effector GogB in disruption of NFκB activation and limitation of the host inflammatory response to infection. GogB alters the NFκB pathway by preventing IκB degradation by the host SCF E3 ubiquitin ligase, through an interaction with Skp1 and FBXO22. The prevention of NFκB activation through this interaction dampens the host inflammatory response in the gut, which in turn limits the damage to host tissues during chronic infection. In this addendum, we summarize these recent findings and discuss their implications and impact in the area of host-pathogen interactions.
authors: Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.
authors: Ana Victoria C
authors: AV
authors: Pilar
authors: Sarah A
authors: SA
authors: Reid-Yu
authors: Colin A
authors: CA
authors: Cooper
authors: David T
authors: DT
authors: Mulder
authors: Brian K
authors: BK
authors: Coombes
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D044783:F-Box Proteins / Q000037:antagonists & inhibitors; D005759:Gastroenteritis / Q000276:immunology* / Q000473:pathology*; D054884:Host-Pathogen Interactions; D006801:Humans; D020672:I-kappa B Proteins / Q000378:metabolism; D057131:Immune Evasion; D008954:Models, Biological; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D044786:S-Phase Kinase-Associated Proteins / Q000037:antagonists & inhibitors; D044843:SKP Cullin F-Box Protein Ligases / Q000378:metabolism; D012481:Salmonella Infections, Animal / Q000276:immunology* / Q000473:pathology*; D019779:Salmonella enterica / Q000276:immunology*; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D044783:F-Box Proteins; D020672:I-kappa B Proteins; D016328:NF-kappa B; D044786:S-Phase Kinase-Associated Proteins; D037521:Virulence Factors; D044843:SKP Cullin F-Box Protein Ligases
keywords: GogB; SCF ligase; SalmonellaTyphimurium; effectors; inflammation; type III secretion system; ubiquitination