title: Angiotensin-converting enzyme gene polymorphisms, blood pressure and pulse pressure in subjects with essential hypertension in a South Sulawesi Indonesian population.
abstract: OBJECTIVE
  to investigate the potential association between the ACE gene polymorphism, essential hypertension and pulse pressure.
  
  
  METHODS
  the study included 99 non-hypertensive and 104 hypertensive subjects. Hypertension is defined as systolic blood pressure 140 mmHg and/or diastolic blood pressure 90 mmHg. Pulse pressure refers to the differences between the systolic blood pressure and diastolic blood pressure. DNA amplication to examine ACE I/D polymorphism was conducted by Rigat-modification PCR method.
  
  
  RESULTS
  this study showed no significant difference in genotype distribution and allele frequency between two groups. We found PP >60 mmHg is different between ACE gene genotype. Genotype DD has a risk of 1.8 times of having PP >60 mmHg than ID genotype while DD genotype has a risk of 4.4 times of having PP >60mg than II genotype.
  
  
  CONCLUSIONS
  this study does not support that the I/D polymorphism at ACE gene locus associated with hypertension in Makassar, South-Sulawesi, Indonesia. However, there were a significant correlation with pulse pressure independent from blood pressure.
authors: Department of Nutrition, Faculty of Medicine, Hasanuddin University. Jl. Perintis Kemerdekaan Km.10 Makasar, 90245, Indonesia. haeranirasyid@yahoo.co.id
authors: Haerani
authors: H
authors: Rasyid
authors: Syakib
authors: S
authors: Bakri
authors: Irawan
authors: I
authors: Yusuf
mesh_terms: D001794:Blood Pressure; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A