title: Citrus ichangensis Peel Extract Exhibits Anti-Metabolic Disorder Effects by the Inhibition of PPARγ and LXR Signaling in High-Fat Diet-Induced C57BL/6 Mouse.
abstract: Obesity is a common nutritional disorder associated with type 2 diabetes, cardiovascular diseases, dyslipidemia, and certain cancers. In this study, we investigated the effects of Citrus ichangensis peel extract (CIE) in high-fat (HF) diet-induced obesity mice. Female C57BL/6 mice were fed a chow diet or an HF diet alone or supplemented with 1% w/w CIE for 8 weeks. We found that CIE treatment could lower blood glucose level and improve glucose tolerance. In the HF+CIE group, body weight gain, serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) levels, and liver triglyceride (TG) and TC concentrations were significantly (P < 0.05) decreased relative to those in the HF group. To elucidate the mechanism of CIE on the metabolism of glucose and lipid, related genes expression in liver were examined. In liver tissue, CIE significantly decreased the mRNA expression levels of peroxisome proliferator-activated receptor γ (PPARγ) and its target genes, such as fatty acid synthase (FAS) and acyl-CoA oxidase (ACO). Moreover, CIE also decreased the expression of liver X receptor (LXR) α and β which are involved in lipid and glucose metabolism. These results suggest that CIE administration could alleviate obesity and related metabolic disorders in HF diet-induced obesity mice through the inhibition of PPARγ and LXR signaling.
authors: College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, China ; Key Laboratory of Horticulture Science for Southern Mountainous Regions, Ministry of Education, Chongqing 400715, China ; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
authors: Xiaobo
authors: X
authors: Ding
authors: Shengjie
authors: S
authors: Fan
authors: Yan
authors: Y
authors: Lu
authors: Yu
authors: Y
authors: Zhang
authors: Ming
authors: M
authors: Gu
authors: Lu
authors: L
authors: Zhang
authors: Gaigai
authors: G
authors: Liu
authors: Lu
authors: L
authors: Guo
authors: Dong
authors: D
authors: Jiang
authors: Xiong
authors: X
authors: Lu
authors: Yiming
authors: Y
authors: Li
authors: Zhiqin
authors: Z
authors: Zhou
authors: Cheng
authors: C
authors: Huang