title: New data, strategies, and insights for Listeria monocytogenes dose-response models: summary of an interagency workshop, 2011.
abstract: Listeria monocytogenes is a leading cause of hospitalization, fetal loss, and death due to foodborne illnesses in the United States. A quantitative assessment of the relative risk of listeriosis associated with the consumption of 23 selected categories of ready-to-eat foods, published by the U.S. Department of Health and Human Services and the U.S. Department of Agriculture in 2003, has been instrumental in identifying the food products and practices that pose the greatest listeriosis risk and has guided the evaluation of potential intervention strategies. Dose-response models, which quantify the relationship between an exposure dose and the probability of adverse health outcomes, were essential components of the risk assessment. However, because of data gaps and limitations in the available data and modeling approaches, considerable uncertainty existed. Since publication of the risk assessment, new data have become available for modeling L. monocytogenes dose-response. At the same time, recent advances in the understanding of L. monocytogenes pathophysiology and strain diversity have warranted a critical reevaluation of the published dose-response models. To discuss strategies for modeling L. monocytogenes dose-response, the Interagency Risk Assessment Consortium (IRAC) and the Joint Institute for Food Safety and Applied Nutrition (JIFSAN) held a scientific workshop in 2011 (details available at http://foodrisk.org/irac/events/). The main findings of the workshop and the most current and relevant data identified during the workshop are summarized and presented in the context of L. monocytogenes dose-response. This article also discusses new insights on dose-response modeling for L. monocytogenes and research opportunities to meet future needs.
authors: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, USA.
authors: K
authors: K
authors: Hoelzer
authors: Y
authors: Y
authors: Chen
authors: S
authors: S
authors: Dennis
authors: P
authors: P
authors: Evans
authors: R
authors: R
authors: Pouillot
authors: B J
authors: BJ
authors: Silk
authors: I
authors: I
authors: Walls
mesh_terms: D000818:Animals; D004196:Disease Outbreaks; D004305:Dose-Response Relationship, Drug; D005506:Food Contamination; D005516:Food Microbiology; D006801:Humans; D055552:Infectious Disease Medicine / Q000379:methods; D007928:Lethal Dose 50; D008089:Listeria monocytogenes / Q000472:pathogenicity*; D008088:Listeriosis / Q000453:epidemiology* / Q000517:prevention & control*; D008253:Macaca mulatta; D051379:Mice; D011634:Public Health; D018570:Risk Assessment; D013045:Species Specificity; D014481:United States
keywords: Dose-response; Listeria monocytogenes; risk assessment