title: [Pharmacological correction of nonspecific resistance and production of proinflammatory cytokines during chronic intoxication with organophosphorus compound VX].
abstract: It is established in experiments on noninbred rats that the use of imunofan (20 mg/kg daily) and polyoxidonium (150 mg/kg daily) for 7 days on the background of chronic intoxication with organophosphorus agent VX (0.01 LD50, single daily treatment for 30 days) resulted in almost complete recovery of phagocytic-metabolic activity of neutrophils, the content of lysozyme, cationic protein of platelet, and levels of proinflammatory cytokines TNFa, IL-1b and IL-6 in the blood. The administration of T-activin (20 mg/kg daily for 7 days) restores these parameters insignificantly. The maximum overall stimulatory effect was produced by polyoxidonium, while the minimum effect was observed for T-activin.
authors: P F
authors: PF
authors: Zabrodskiĭ
authors: V A
authors: VA
authors: Grishin
mesh_terms: D000818:Animals; D000931:Antidotes / Q000494:pharmacology* / Q000627:therapeutic use; D002619:Chemical Warfare Agents / Q000633:toxicity*; D005260:Female; D005739:Gas Poisoning / Q000188:drug therapy / Q000276:immunology; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009113:Muramidase / Q000097:blood; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D009842:Oligopeptides / Q000494:pharmacology* / Q000627:therapeutic use; D009946:Organothiophosphorus Compounds / Q000037:antagonists & inhibitors / Q000633:toxicity*; D010455:Peptides / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology* / Q000627:therapeutic use; D011108:Polymers / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013949:Thymus Extracts / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000931:Antidotes; D002619:Chemical Warfare Agents; D007155:Immunologic Factors; D053583:Interleukin-1beta; D015850:Interleukin-6; D009113:Muramidase; D009842:Oligopeptides; D009946:Organothiophosphorus Compounds; D010455:Peptides; D010879:Piperazines; D011108:Polymers; D013949:Thymus Extracts; D014409:Tumor Necrosis Factor-alpha; C080035:thymohexin; C036191:T-activin; C540909:azoximer bromide; C009680:VX-agent