title: Expression and significance of VEGF and p53 in degenerate intervertebral disc tissue.
abstract: OBJECTIVE
  To investigate the mechanism of expression and significance of vascular endothelial growth factor (VEGF) and p53 in degenerate intervertebral disc tissue.
  
  
  METHODS
  Pathological sections collected from 156 patients with lumbar disc herniation after surgery were tested by immunohistochemistry method, for evaluation of the expression of VEGF and p53 in degenerate intervertebral disc tissue.
  
  
  RESULTS
  98 cases (62.8%) with vascular infiltration phenomenon are found, and positive rates of VEGF and p53 in degenerate intervertebral disc tissue are 73.42% (116/156) and 58.97% (92/156); co-expression rate is 53.2%(83/156); the expression rates of VEFG and p53 are significantly higher in the tissue with blood vessel infiltration than in the tissue without infiltration; there is a close relationship of VEGF with p53.
  
  
  CONCLUSIONS
  VEGF and p53 gene synergetic express in degenerate intervertebral disc tissue, working together in neovascularization and infiltration, and accelerating intervertebral disc tissue degeneration.
authors: Rehabilitation Medicine, Hospital of Special Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China 510010.
authors: Xiao-Yu
authors: XY
authors: Lu
authors: Xiao-Hong
authors: XH
authors: Ding
authors: Li-Jun
authors: LJ
authors: Zhong
authors: Hong
authors: H
authors: Xia
authors: Xiao-Dong
authors: XD
authors: Chen
authors: Hai
authors: H
authors: Huang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007403:Intervertebral Disc / Q000378:metabolism; D055959:Intervertebral Disc Degeneration / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A