title: Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities.
abstract: OBJECTIVE
  To investigate the associations between interleukin (IL)-1B and IL-1RN polymorphisms and gastric cancers among the Tibet, Hui and Han ethnicities.
  
  
  METHODS
  Genomic DNA was extracted from peripheral blood of 210, 205, and 202 healthy volunteers and from 155, 158, and 197 gastric cancer patients from the Tibet, Hui, and Han populations, respectively. Polymorphisms in IL-1B and IL-1RN were analyzed by denaturing high-performance liquid chromatography.
  
  
  RESULTS
  Carriers of the IL-1B-31 CC genotype had an increased risk of intestinal type gastric cancer [odds ratio (OR) = 2.17, P = 0.037] in the Tibet ethnicity. Carriers of the IL-1B 2/L genotype had an increased risk of both intestinal and diffuse types of gastric cancer (OR = 2.08, 2.31, P = 0.007, 0.016, respectively) in the Hui ethnicity. In the Han population, carriers of the IL-1B-31 CC, IL-1B-511CT, TT genotypes had increased risk of intestinal type gastric cancer (OR = 2.51, 2.74, 5.66, P = 0.005, 0.002, 0.000, respectively).
  
  
  CONCLUSIONS
  IL-1B and IL-RN genotypes may differentially contribute to gastric cancer among the Tibet, Hui, and Han ethnicities in the Qinghai area of China.
authors: Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining 810000, Qinghai Province, China. jiudazhao@126.com
authors: Jiu-Da
authors: JD
authors: Zhao
authors: Pai-Li
authors: PL
authors: Geng
authors: Zhan-Quan
authors: ZQ
authors: Li
authors: Sen
authors: S
authors: Cui
authors: Jun-Hui
authors: JH
authors: Zhao
authors: Li-Juan
authors: LJ
authors: Wang
authors: Jin-Zhang
authors: JZ
authors: Li
authors: Fa-Xiang
authors: FX
authors: Ji
authors: Guo-Yuan
authors: GY
authors: Li
authors: Guo-Shuang
authors: GS
authors: Shen
authors: Ming-Zhe
authors: MZ
authors: Lin
authors: Cun-Fang
authors: CF
authors: Shen
authors: Cheng-Zhu
authors: CZ
authors: Cao
mesh_terms: D000328:Adult; D002681:China; D002851:Chromatography, High Pressure Liquid; D004797:Enzyme-Linked Immunosorbent Assay; D005006:Ethnicity; D005260:Female; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000208:ethnology* / Q000235:genetics*
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1
keywords: Gastric cancer; Interleukin-1B; Interleukin-1RN; Polymorphism; Risk of gastric cancer