title: Animal models of osteoarthritis: challenges of model selection and analysis.
abstract: Osteoarthritis (OA) is the most common musculoskeletal disease, affecting millions of individuals worldwide. New treatment approaches require an understanding of the pathophysiology of OA and its biomechanical, inflammatory, genetic, and environmental risk factors. The purpose of animal models of OA is to reproduce the pattern and progression of degenerative damage in a controlled fashion, so that opportunities to monitor and modulate symptoms and disease progression can be identified and new therapies developed. This review discusses the features, strengths, and weaknesses of the common animal models of OA; considerations to be taken when choosing a method for experimental induction of joint degeneration; and the challenges of measuring of OA progression and symptoms in these models.
authors: Department of Emergency Medicine, Brown Medical School/Rhode Island Hospital, 1 Hoppin Street Coro West, Suite 106, Providence, RI 02903, USA. Erin_Teeple@brown.edu
authors: Erin
authors: E
authors: Teeple
authors: Gregory D
authors: GD
authors: Jay
authors: Khaled A
authors: KA
authors: Elsaid
authors: Braden C
authors: BC
authors: Fleming
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D018771:Arthralgia / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D018450:Disease Progression; D005684:Gait; D007596:Joints / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D010003:Osteoarthritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D010147:Pain Measurement; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013045:Species Specificity; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers