title: On optimal and suboptimal treatment strategies for a mathematical model of leukemia.
abstract: In this work an optimization problem for a leukemia treatment model based on the Gompertzian law of cell growth is considered. The quantities of the leukemic and of the healthy cells at the end of the therapy are chosen as the criterion of the treatment quality. In the case where the number of healthy cells at the end of the therapy is higher than a chosen desired number, an analytical solution of the optimization problem for a wide class of therapy processes is given. If this is not the case, a control strategy called alternative is suggested.
authors: Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany. e.fimmel@hs-mannheim.de
authors: Elena
authors: E
authors: Fimmel
authors: Yury S
authors: YS
authors: Semenov
authors: Alexander S
authors: AS
authors: Bratus
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000627:therapeutic use; D049109:Cell Proliferation; D003198:Computer Simulation; D004358:Drug Therapy / Q000379:methods; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D008495:Medical Oncology / Q000379:methods; D008954:Models, Biological; D015233:Models, Statistical; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents