title: Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii.
abstract: BACKGROUND
  Malaria is the most significant human parasitic disease, and yet understanding of the energy metabolism of the principle pathogen, Plasmodium falciparum, remains to be fully elucidated. Amino acids were shown to be essential nutritional requirements since early times and much of the current knowledge of Plasmodium energy metabolism is based on early biochemical work, performed using basic analytical techniques, carried out almost exclusively on human plasma with considerable inter-individual variability.
  
  
  METHODS
  In order to further characterize the fate of amino acid metabolism in malaria parasite, multivariate analysis using statistical modelling of amino acid concentrations (aminogram) of plasma and liver were determined in host infected with rodent malaria parasite, Plasmodium yoelii.
  
  
  CONCLUSIONS
  Comprehensive and statistical aminogram analysis revealed that P. yoelii infection caused drastic change of plasma and liver aminogram, and altered intra- and inter-correlation of amino acid concentration in plasma and liver. These findings of the interactions between amino acids and Plasmodium infection may provide insight to reveal the interaction between nutrients and parasites.
authors: Department of Tropical Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Tokyo 105-8461, Japan.
authors: Erisha
authors: E
authors: Saiki
authors: Kenji
authors: K
authors: Nagao
authors: Hiroka
authors: H
authors: Aonuma
authors: Shinya
authors: S
authors: Fukumoto
authors: Xuenan
authors: X
authors: Xuan
authors: Makoto
authors: M
authors: Bannai
authors: Hirotaka
authors: H
authors: Kanuka
mesh_terms: D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D004195:Disease Models, Animal; D008099:Liver / Q000737:chemistry*; D008288:Malaria / Q000473:pathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010949:Plasma / Q000737:chemistry*; D010967:Plasmodium yoelii / Q000472:pathogenicity*
chemical_list: D000596:Amino Acids