title: Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts.
abstract: The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C16-KTTKS is investigated and related to its self-assembly into nanotape structures. This PA is used in antiwrinkle cosmeceutical applications (trade name Matrixyl). We prove that C16-KTTKS stimulates collagen production in a concentration-dependent manner close to the critical aggregation concentration determined from pyrene fluorescence spectroscopy. This suggests that self-assembly and the stimulation of collagen production are inter-related.
authors: School of Chemistry, Food and Pharmacy, University of Reading , Reading RG6 6AD, U.K.
authors: Roanne R
authors: RR
authors: Jones
authors: Valeria
authors: V
authors: Castelletto
authors: Che J
authors: CJ
authors: Connon
authors: Ian W
authors: IW
authors: Hamley
mesh_terms: D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism*; D003315:Cornea / Q000166:cytology; D020405:Dermis / Q000166:cytology; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D009842:Oligopeptides / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence
chemical_list: D009842:Oligopeptides; C525923:lysyl-threonyl-threonyl-lysyl-serine; D003094:Collagen