title: Predicting growth response among Egyptian prepubertal idiopathic isolated growth hormone deficient children.
abstract: OBJECTIVE
  To determine the predictors of growth response to growth hormone treatment in a group of isolated idiopathic growth hormone (GH).
  
  
  METHODS
  477 GH deficient (GHD) children with GH therapy were included in the study. Patients were followed up for a minimum of 1 year and up to 6 years. Multiple linear regressions were performed to identify predictors of growth response to rhGH in the first 4 years of treatment.
  
  
  RESULTS
  In the first year, three significant predictors of growth were identified: GH peak [ln (ug/L)], age of onset of therapy and target height-height SDS. In the second and third years of therapy, growth velocity (GV) was both significantly and positively correlated to the GV (cm/year) of the previous year.
  
  
  CONCLUSIONS
  Prediction models offer a valuable tool for individualization and assuring adherence to rhGH and thus a cost effective treatment, which is the ultimate goal of GH therapy.
authors: Pediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors: Nermin
authors: N
authors: Salah
authors: Soha M
authors: SM
authors: Abd El Dayem
authors: Lobna
authors: L
authors: Fawaz
authors: Marwa
authors: M
authors: Ibrahim
mesh_terms: D001827:Body Height / Q000187:drug effects / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004534:Egypt / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D011237:Predictive Value of Tests; D011627:Puberty / Q000502:physiology*; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone