title: [The effect of exenatide analogs on hydruretic function of rat kidney under water load].
abstract: Injection (0.05 nmol/100 g b.w.) of exenatide or its amino-acid-substituted synthetic analogs I (substitution at positions 14 and 39) and II (substitution at positions 14, 35, and 39) led to an increase in diuresis and excretion of sodium, magnesium and potassium, but only exenatide caused the excretion of solute free water. In experiments with 1% water load, only exenatide analog I stimulated the solute free water excretion. These features of exenatide and its analogs show the possibility of searching for substances with various power of action upon ion and water excretion by the kidney, which may have a clinical significance.
authors: A E
authors: AE
authors: Bogolepova
authors: E I
authors: EI
authors: Shakhmatova
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D060766:Drinking Water / Q000378:metabolism*; D000077270:Exenatide; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007677:Kidney Function Tests; D008274:Magnesium / Q000652:urine*; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D011188:Potassium / Q000652:urine*; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000652:urine*; D014688:Venoms / Q000138:chemical synthesis / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D060766:Drinking Water; D007004:Hypoglycemic Agents; D010455:Peptides; D014688:Venoms; D012964:Sodium; D000077270:Exenatide; D008274:Magnesium; D011188:Potassium