title: [Changes of glutamate and γ-aminobutyric acid of extracellular fluid in hippocampus during electrical stimulation of anterior nucleus thalamus in rats].
abstract: OBJECTIVE
  To explore the changes of extracellular glutamate (Glu) and γ-aminobutyric acid (GABA) in hippocampus during the high-frequency stimulation of anterior nucleus thalamus (ANT) in epileptic rats.
  
  
  METHODS
  A total of 30 rats were divided equally into 2 groups:epilepsy model and normal control (n = 15 each). Concentric bipolar electrodes were stereotaxically implanted in bilateral ANT. A high-frequency stimulation of 130 Hz was applied in the epilepsy group. Microdialysis probes were unilaterally lowered into hippocampus. The concentrations of Glu and GABA in dialysate samples were determined by high-performance liquid chromatography (HPLC).
  
  
  RESULTS
  Electrical stimulation of ANT induced an increase of GABA and a decrease of Glu in hippocampus.
  
  
  CONCLUSIONS
  An increase of GABA and a decrease of Glu during the electrical stimulation of ANT play an important role in the therapy of epilepsy.
authors: Beijing Tiantan Hospital, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.
authors: Ning
authors: N
authors: Chen
authors: Fan-gang
authors: FG
authors: Meng
authors: Jian-guo
authors: JG
authors: Zhang
authors: An-chao
authors: AC
authors: Yang
authors: Huan-guang
authors: HG
authors: Liu
authors: Wen-han
authors: WH
authors: Hu
authors: Da-wei
authors: DW
authors: Meng
authors: Xin
authors: X
authors: Zhang
authors: Chong
authors: C
authors: Liu
authors: Yan
authors: Y
authors: Ge
mesh_terms: D000818:Animals; D020643:Anterior Thalamic Nuclei; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004827:Epilepsy / Q000378:metabolism / Q000628:therapy*; D045604:Extracellular Fluid / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid