title: Relationship between electrodiagnostic severity and neuropathic pain assessed by the LANSS pain scale in carpal tunnel syndrome.
abstract: OBJECTIVE
  The aim of the study was to investigate the relationship between the presence of neuropathic pain assessed by the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale and electrophysiological findings in patients with carpal tunnel syndrome (CTS).
  
  
  METHODS
  We studied 124 hands with idiopathic CTS with pain complaints involving hand and wrist. All hands were assessed by the LANSS with which a score of 12 or more is defined as pain dominated by neuropathic mechanisms. These hands were assigned to minimal, mild, moderate, severe, or extreme severe groups according to the results of the median nerve conduction studies.
  
  
  RESULTS
  A LANSS score ≥ 12, suggestive of pain dominated by neuropathic mechanisms, was defined in 59 (47.6%) CTS hands. Pain intensity was significantly higher in CTS hands with a LANSS score ≥ 12 (P < 0.001). Among electrophysiological findings, compound muscle action potential amplitude was significantly lower in hands with a LANSS score ≥ 12 compared with hands with a LANSS score < 12 (P = 0.020). Severity of CTS was not significantly different between LANSS ≥ 12 and LANSS < 12 groups. Electrophysiological severity was significantly higher in CTS hands with evoked pain (P = 0.005) and allodynia (P < 0.001) in LANSS subscore analysis.
  
  
  CONCLUSIONS
  We suggest that the presence of pain dominated by neuropathic mechanisms in CTS is not related to electrophysiological CTS severity. Neuropathic pain should be assessed carefully in patients with CTS, and an appropriate treatment plan should be chosen, taking into account the clinical and electrophysiological findings together with the true pain classification.
authors: Department of Neurology, Bezmialem Vakıf University, Istanbul, Turkey.
authors: Azize Esra
authors: AE
authors: Gürsoy
authors: Mehmet
authors: M
authors: Kolukısa
authors: Gülsen Babacan
authors: GB
authors: Yıldız
authors: Gülşen
authors: G
authors: Kocaman
authors: Arif
authors: A
authors: Celebi
authors: Abdülkadir
authors: A
authors: Koçer
keywords: LANSS; carpal tunnel syndrome; electrodiagnostic evaluation; neuropathic pain