title: The paradoxical functions of B cells and antibodies in transplantation.
abstract: Scarcely anyone would dispute that donor-specific B cells and the Abs that they produce can cause rejection of transplants. Less clear and more controversial, however, is the possibility that donor-specific B cells and the Abs that they produce are one or more means by which transplants can be protected from injury. In this article, we review and discuss this possibility and consider how less well-known functions of B cells and Abs might impact on the design of therapeutics and the management of transplant recipients.
authors: Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. marilia@umich.edu
authors: Marilia I
authors: MI
authors: Cascalho
authors: Brian J
authors: BJ
authors: Chen
authors: Mandy
authors: M
authors: Kain
authors: Jeffrey L
authors: JL
authors: Platt
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D001402:B-Lymphocytes / Q000276:immunology*; D060833:Cellular Microenvironment; D006649:Histocompatibility Antigens / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007518:Isoantibodies / Q000276:immunology; D016030:Kidney Transplantation; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology
chemical_list: D006649:Histocompatibility Antigens; D007518:Isoantibodies