title: Association between family members of dialysis patients and chronic kidney disease: a multicenter study in China.
abstract: BACKGROUND
  Family members of patients with end stage renal disease were reported to have an increased prevalence of chronic kidney disease (CKD). However, studies differentiated genetic and non-genetic family members are limited. We sought to investigate the prevalence of CKD among fist-degree relatives and spouses of dialysis patients in China.
  
  
  METHODS
  Seventeen dialysis facilities from 4 cities of China including 1062 first-degree relatives and 450 spouses of dialysis patients were enrolled. Sex- and age- matched controls were randomly selected from a representative sample of general population in Beijing. CKD was defined as decreased estimated glomerular (eGFR<60 mL/min/1.73 m2) or albuminuria.
  
  
  RESULTS
  The prevalence of eGFR less than 60 mL/min/1.73 m2, albuminuria and the overall prevalence of CKD in dialysis spouses were compared with their counterpart controls, which was 3.8% vs. 7.8% (P<0.01), 16.8% vs. 14.6% (P=0.29) and 18.4% vs. 19.8% (P=0.61), respectively. The prevalence of eGFR less than 60 mL/min/1.73 m2, albuminuria and the overall prevalence of CKD in dialysis relatives were also compared with their counterpart controls, which was 1.5% vs. 2.4% (P=0.12), 14.4% vs. 8.4% (P<0.01) and 14.6% vs. 10.5% (P<0.01), respectively. Multivariable Logistic regression analysis indicated that being spouses of dialysis patients is negatively associated with presence of low eGFR, and being relatives of dialysis patients is positively associated with presence of albuminuria.
  
  
  CONCLUSIONS
  The association between being family members of dialysis patients and presence of CKD is different between first-degree relatives and spouses. The underlying mechanisms deserve further investigation.
authors: Renal Division, Department of Medicine, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, 100034, China.
authors: Xianglei
authors: X
authors: Kong
authors: Li
authors: L
authors: Liu
authors: Li
authors: L
authors: Zuo
authors: Ping
authors: P
authors: Yuan
authors: Zhongxin
authors: Z
authors: Li
authors: Wenge
authors: W
authors: Li
authors: Meishun
authors: M
authors: Cai
authors: Xiangmei
authors: X
authors: Chen
authors: Aili
authors: A
authors: Jiang
authors: Gang
authors: G
authors: Long
authors: Jinsheng
authors: J
authors: Xu
authors: Hongli
authors: H
authors: Lin
authors: Shixiang
authors: S
authors: Wang
authors: Wen
authors: W
authors: Huang
authors: Yiping
authors: Y
authors: Wang
authors: Yidan
authors: Y
authors: Guo
authors: Po
authors: P
authors: Cao
authors: Hua
authors: H
authors: Wu
authors: Qiang
authors: Q
authors: Jia
authors: Luxia
authors: L
authors: Zhang
authors: Mei
authors: M
authors: Wang
authors: Haiyan
authors: H
authors: Wang
mesh_terms: D003956:Dialysis / Q000706:statistics & numerical data*; D005190:Family; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors; D018454:Spouses / Q000706:statistics & numerical data*