title: Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights.
abstract: BACKGROUND
  Deep brain stimulation has shed new light on the central role of the prefrontal cortex (PFC) in obsessive compulsive disorder (OCD). We explored this structure from a functional perspective, synchronizing neuroimaging and cognitive measures.
  
  
  RESULTS
  This case-control cross-sectional study compared 15 OCD patients without comorbidities and not currently on serotonin reuptake inhibitors or cognitive behavioural therapy with 15 healthy controls (matched for age, sex and education level) on resting-state (18)FDG-PET scans and a neuropsychological battery assessing executive functions. We looked for correlations between metabolic modifications and impaired neuropsychological scores. Modifications in glucose metabolism were found in frontal regions (orbitofrontal cortex and dorsolateral cortices), the cingulate gyrus, insula and parietal gyrus. Neuropsychological differences between patients and controls, which were subtle, were correlated with the metabolism of the prefrontal, parietal, and temporal cortices.
  
  
  CONCLUSIONS
  As expected, we confirmed previous reports of a PFC dysfunction in OCD patients, and established a correlation with cognitive deficits. Other regions outside the prefrontal cortex, including the dorsoparietal cortex and the insula, also appeared to be implicated in the pathophysiology of OCD, providing fresh insights on the complexity of OCD syndromes.
authors: University Department of Adult Psychiatry, Guillaume Régnier Hospital, Rennes, France.
authors: Bruno
authors: B
authors: Millet
authors: Thibaut
authors: T
authors: Dondaine
authors: Jean-Michel
authors: JM
authors: Reymann
authors: Aurélie
authors: A
authors: Bourguignon
authors: Florian
authors: F
authors: Naudet
authors: Nematollah
authors: N
authors: Jaafari
authors: Dominique
authors: D
authors: Drapier
authors: Valérie
authors: V
authors: Turmel
authors: Habiba
authors: H
authors: Mesbah
authors: Marc
authors: M
authors: Vérin
authors: Florence
authors: F
authors: Le Jeune
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D053858:Metabolic Networks and Pathways; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000523:psychology*; D049268:Positron-Emission Tomography; D057190:Stroop Test; D014705:Verbal Behavior
chemical_list: D005947:Glucose