title: Interaction between oral lichen planus and chronic periodontitis with Th17-associated cytokines in serum.
abstract: The objective of this study was to compare the expression levels of interleukin (IL)-17 IL-17 and IL-23 in serum from patients with both oral lichen planus and chronic periodontitis (OLP-CP), patients only with oral lichen planus (OLP), patients only with chronic periodontitis (CP), and healthy controls (HC). The serum samples were collected from 35 OLP-CP patients, 35 OLP patients, 30 CP patients, and 30 healthy controls. ELISA test was used to detect expression levels of IL-17 and IL-23 in serum from these four groups. ELISA analysis showed significantly elevated levels of serum IL-17 in OLP-CP group compared with OLP group (P < 0.05) and HC group (P < 0.01). Serum IL-23 result showed that there was an increased expression level in OLP-CP compared with HC group (P < 0.01). Additionally, female OLP-CP group showed elevated level of serum IL-17 compared with female OLP group, and also erosive OLP-CP group demonstrated increased serum IL-17 level compared with erosive OLP group. Moreover, analysis showed positive significant correlations of serum IL-17 level with probing depth (P < 0.05) and plaque index (P < 0.05) in erosive OLP-CP patients. This study indicates that OLP-CP patients get higher expression level of serum IL-17 and had susceptibility to erosive or female subtype, which indicated that IL-17 may participate in the disease immunopathogenesis of both common oral diseases.
authors: Department of Oral Medicine, School of Stomatology, Capital Medical University, Beijing, China.
authors: Hui
authors: H
authors: Wang
authors: Zhenhua
authors: Z
authors: Luo
authors: Lei
authors: L
authors: Lei
authors: Zheng
authors: Z
authors: Sun
authors: Min
authors: M
authors: Zhou
authors: Hongxia
authors: H
authors: Dan
authors: Xin
authors: X
authors: Zeng
authors: Qianming
authors: Q
authors: Chen
mesh_terms: D000328:Adult; D055113:Chronic Periodontitis / Q000097:blood / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D053759:Interleukin-23 / Q000097:blood*; D017676:Lichen Planus, Oral / Q000097:blood / Q000150:complications / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23