title: Fusion of laboratory and textual data for investigative bioforensics.
abstract: Chemical and biological forensic programs focus on the identification of a threat and acquisition of laboratory measurements to determine how a threat agent may have been produced. However, to generate investigative leads, it might also be useful to identify institutions where the same agent has been produced by the same or a very similar process, since the producer of the agent may have learned methods at a university or similar institution. We have developed a Bayesian network framework that fuses hard and soft data sources to assign probability to production practices. It combines the results of laboratory measurements with an automatic text reader to scan scientific literature and rank institutions that had published papers on the agent of interest in order of the probability that the institution has the capability to generate the sample of interest based on laboratory data. We demonstrate the Bayesian network on an example case from microbial forensics, predicting the methods used to produce Bacillus anthracis spores based on mass spectrometric measurements and identifying institutions that have a history of growing Bacillus spores using the same or highly similar methods. We illustrate that the network model can assign a higher posterior probability than expected by random chance to appropriate institutions when trained using only a small set of manually analyzed documents. This is the first example of an automated methodology to integrate experimental and textual data for the purpose of investigative forensics.
authors: Computational Biology & Bioinformatics, Pacific Northwest National Laboratory, 902 Battelle Blvd, Richland, WA 99352, USA. bj@pnnl.gov
authors: Bobbie-Jo
authors: BJ
authors: Webb-Robertson
authors: Courtney
authors: C
authors: Corley
authors: Lee Ann
authors: LA
authors: McCue
authors: Karen
authors: K
authors: Wahl
authors: Helen
authors: H
authors: Kreuzer
mesh_terms: D001408:Bacillus anthracis; D001499:Bayes Theorem; D003627:Data Interpretation, Statistical; D057225:Data Mining / Q000379:methods*; D044707:Forensic Sciences; D006801:Humans; D007753:Laboratories; D016571:Neural Networks, Computer; D013171:Spores, Bacterial