title: Dosimetric impact of interfraction catheter movement and organ motion on MRI/CT guided HDR interstitial brachytherapy for gynecologic cancer.
abstract: OBJECTIVE
  To determine the dosimetric impact of catheter movement for MRI/CT image guided high dose rate (HDR) interstitial brachytherapy (ISBT) for gynecologic cancers.
  
  
  METHODS
  Ten patients were treated with HDR ISBT. The CTV and organs at risk were contoured using a postimplant MRI and CT. 5 fractions were delivered twice daily on 3 consecutive days. The first fraction was delivered on day 1 (d1), fraction 2-3 on d2 and fraction 4-5 on d3. MRI/CT was acquired prior to the second and fourth fractions. Four scenarios were modeled. (1) The d1 plan was applied to the d2 and d3 CT, using the updated catheter positions. (2) Replanning was performed for d2 and d3. (3) We applied the dwell positions/times from the d2 replan over the d3 CT and compared with a d3 CT replan. (4) Based on daily MRI, target volumes were recontoured and replanned. Dosimetry was analyzed for each plan and compared to the d1 dose distribution.
  
  
  RESULTS
  (1) When using the d1 plan on the d2 and d3 CT with the updated catheter positions, the mean CTV D90 was reduced from 93.4% on d1 to 89.3% (p=0.08) on d2 and to 87.7% (p=0.005) on d3. (2) Replanning on d2 and d3 compensated for catheter movement, mean CTV D90 of 95.4% on d2 and 94.6% (p=0.36) on d3. (3) When compared to the replan of d2 applied on the d3 CT vs the d3 replan, there was no significant difference in coverage, mean CTV D90 of 90.9% (p=0.09). (4) Reoptimization based on daily MRI, significantly improved the CTV coverage for each day. The mean D2cc for the rectum was significantly higher with model 1 vs model 3 59.1±4.7 vs 60.9±4.8 (p=0.04) Gy EQD2. There were no significant differences in D2cc of bladder and sigmoid between models.
  
  
  CONCLUSIONS
  Interfraction dosimetric changes significantly decreased the CTV coverage of the third day. Rather than replanning on each day, replanning on the day 2 CT before the second or third fraction would give an optimal solution that would compensate for interfraction catheter displacement.
authors: Department of Radiation Oncology, University of Pennsylvania, Philadelphia 19104, United States.
authors: Felipe
authors: F
authors: Rey
authors: Chang
authors: C
authors: Chang
authors: Carmen
authors: C
authors: Mesina
authors: Nayha
authors: N
authors: Dixit
authors: Boon-Keng
authors: BK
authors: Kevin Teo
authors: Lilie L
authors: LL
authors: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D057785:Catheters; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D008875:Middle Aged; D009068:Movement; D011879:Radiotherapy Dosage; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D047368:Tumor Burden