title: Neutralizing tumor-promoting chronic inflammation: a magic bullet?
abstract: There have been substantial advances in cancer diagnostics and therapies in the past decade. Besides chemotherapeutic agents and radiation therapy, approaches now include targeting cancer cell-intrinsic mediators linked to genetic aberrations in cancer cells, in addition to cancer cell-extrinsic pathways, especially those regulating vascular programming of solid tumors. More recently, immunotherapeutics have entered the clinic largely on the basis of the recognition that several immune cell subsets, when chronically activated, foster tumor development. Here, we discuss clinical and experimental studies delineating protumorigenic roles for immune cell subsets that are players in cancer-associated inflammation. Some of these cells can be targeted to reprogram their function, leading to resolution, or at least neutralization, of cancer-promoting chronic inflammation, thereby facilitating cancer rejection.
authors: Department of Cell and Developmental Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239-3098, USA. coussenl@ohsu.edu
authors: Lisa M
authors: LM
authors: Coussens
authors: Laurence
authors: L
authors: Zitvogel
authors: A Karolina
authors: AK
authors: Palucka
mesh_terms: D000906:Antibodies / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000276:immunology / Q000473:pathology; D044584:Carcinoma, Ductal / Q000276:immunology / Q000473:pathology; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000276:immunology; D002908:Chronic Disease; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000276:immunology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007249:Inflammation / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D007962:Leukocytes / Q000276:immunology*; D022423:Myeloid Cells / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*
chemical_list: D000906:Antibodies; D018925:Chemokines; D016207:Cytokines