title: [Effect of the third generation beta-blockers on ion-regulating renal function in rats with heart failure model].
abstract: Beta-adrenoceptor blockers nebivolol and carvedilol do not affect diuresis and renal sodium excretion in intact rats, but significantly increase urinary excretion of sodium in animals with a model of heart failure caused by excessive physical exercise and injection of phenylephrine. Nebivolol, in contrast to carvedilol, causes additional increase the urinary potassium loss, which is retained in animals with experimental heart failure. It is concluded that both drugs increase renal sodium excretion in rats with heart failure model by preventing the excessive sodium delay in the body.
authors: N V
authors: NV
authors: Buchneva
authors: O B
authors: OB
authors: Kuz'min
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002227:Carbazoles / Q000494:pharmacology*; D000077261:Carvedilol; D004195:Disease Models, Animal; D004231:Diuresis / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D006333:Heart Failure / Q000139:chemically induced / Q000652:urine*; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D000068577:Nebivolol; D010656:Phenylephrine; D005082:Physical Exertion; D011188:Potassium / Q000652:urine*; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000652:urine*; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D002227:Carbazoles; D004983:Ethanolamines; D011412:Propanolamines; D000068577:Nebivolol; D000077261:Carvedilol; D010656:Phenylephrine; D012964:Sodium; D011188:Potassium