title: Doramectin toxicity in a group of lions (Panthera leo).
abstract: Ten lions (Panthera leo) that were treated with a single injection of doramectin at a dose ranging  between 0.2 mg/kg and 0.5 mg/kg showed clinical signs consistent with avermectin toxicity,  namely ataxia, hallucinations, and mydriasis. Two subsequently died whereas the other eight  lions recovered after 4-5 days with symptomatic therapy. Post-mortem examinations of the  two that died showed cyanosis, severe pulmonary oedema, pleural effusion, and pericardial  effusion, with histopathology not revealing any abnormalities. In both these lions, doramectin  brain and liver tissue concentrations were elevated. Although doramectin is regularly used  in wild felids, to date there have been no reports of avermectin toxicity in the literature. This  article highlights the potential for doramectin toxicity in this species.
authors: Bryanston Veterinary Hospital, Bryanston, South Africa. rlobetti@mweb.co.za
authors: Remo G
authors: RG
authors: Lobetti
authors: Peter
authors: P
authors: Caldwell
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000009:adverse effects*; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000662:veterinary*; D007559:Ivermectin / Q000009:adverse effects / Q000031:analogs & derivatives*; D008045:Lions
chemical_list: D000871:Anthelmintics; D007559:Ivermectin; C084101:doramectin