title: Molecular heterogeneity and centrosome-associated genes in multiple myeloma.
abstract: In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profiling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosome-associated genes in patients with MM. We identified the gene pattern with an impact on myeloma pathogenesis. According to expression tendency, three subgroups of patients were established. The revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System. Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis. We believe that future investigation of this molecular heterogeneity will help to refine the broad prognoses offered by present-day established systems and even sub-stratify them.
authors: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors: Fedor
authors: F
authors: Kryukov
authors: Pavel
authors: P
authors: Nemec
authors: Elena
authors: E
authors: Dementyeva
authors: Lenka
authors: L
authors: Kubiczkova
authors: Ivana
authors: I
authors: Ihnatova
authors: Eva
authors: E
authors: Budinska
authors: Jiri
authors: J
authors: Jarkovsky
authors: Sabina
authors: S
authors: Sevcikova
authors: Petr
authors: P
authors: Kuglik
authors: Roman
authors: R
authors: Hajek
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018385:Centrosome / Q000378:metabolism*; D016000:Cluster Analysis; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D008938:Mitosis / Q000235:genetics; D009101:Multiple Myeloma / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D015203:Reproducibility of Results; D016896:Treatment Outcome