title: Endothelial nitric oxide synthase gene polymorphisms and risk of preeclampsia.
abstract: Polymorphisms in endothelial nitric oxide synthase (eNOS) gene may affect the risk of preeclampsia. This systematic review aimed to provide an updated review of the literature to better understand the association between the eNOS gene polymorphisms and the risk of preeclampsia. We searched electronic databases of the human literature in PubMed, EMBASE, and the Cochrane Library up to July 2012. A meta-analysis was conducted on the association of eNOS G894T, T786C, and intron 4b/a polymorphisms with preeclampsia using (1) allele contrast, (2) recessive, (3) dominant, and (4) additive models. Thirty-three studies comprising 10,671 participants met the inclusion criteria. There was statistically significant association between the G894T variant and increased risk of preeclampsia (TT versus TG + GG: odds ratio 1.43, 95% confidence interval: 1.13 to 1.82). However, no significant risk of preeclampsia was observed either in the T786C or the intron 4b/a polymorphism. Homozygosity TT in eNOS G894T variant is significantly associated with an increased risk of preeclampsia.
authors: Department of Ophthalmology, the First Affiliated Hospital, Harbin Medical University, China.
authors: Hui-Ping
authors: HP
authors: Qi
authors: William D
authors: WD
authors: Fraser
authors: Zhong-Cheng
authors: ZC
authors: Luo
authors: Pierre
authors: P
authors: Julien
authors: Francois
authors: F
authors: Audibert
authors: Shu-Qin
authors: SQ
authors: Wei
mesh_terms: D005260:Female; D006801:Humans; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000235:genetics*; D012306:Risk
chemical_list: D052250:Nitric Oxide Synthase Type III