title: Glucose metabolism in obese and lean adolescents with polycystic ovary syndrome.
abstract: Data on glucose metabolism in Asian adolescents with polycystic ovary syndrome (PCOS) are limited. Glucose metabolism assessment using an oral glucose tolerance test (OGTT) in obese and lean Thai adolescents with PCOS, and a comparison between the two groups were done. Thirty-one patients (19 obese, 12 lean) were enrolled. Their median (range) age was 14.9 (11.0-21.0) years. Eighteen patients had abnormal glucose metabolism (13 hyperinsulinemia, 4 impaired glucose tolerance, and 1 diabetes). Compared between obese [median (range) BMI Z-score, 1.6 (1.2-2.6)] and lean [median (range) BMI Z-score, 0.1 (-1.4 to 0.6)] patients, the frequencies of each abnormal OGTT category, areas under the curves of glucose and insulin levels, and insulinogenic index were not different; however, insulin resistance was greater in the obese group. In conclusion, a high proportion of our adolescents with PCOS had abnormal glucose metabolism. Therefore, OGTT should be performed in adolescents with PCOS for the early detection of abnormal glucose metabolism.
authors: Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. preamrudee.poo@mahidol.ac.th
authors: Preamrudee
authors: P
authors: Poomthavorn
authors: Weerapong
authors: W
authors: Chaya
authors: Pat
authors: P
authors: Mahachoklertwattana
authors: Matchuporn
authors: M
authors: Sukprasert
authors: Sawaek
authors: S
authors: Weerakiet
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D018149:Glucose Intolerance / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D008954:Models, Biological; D009765:Obesity / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D013851:Thinness / Q000378:metabolism*; D055815:Young Adult
chemical_list: D001786:Blood Glucose