title: Scintigraphic detection of colon carcinomas with iodinated monoclonal antibodies.
abstract: OBJECTIVE
  The aim of this study was to evaluate the clinical reliability of the immunoscintigraphy with iodinated monoclonal antibodies for the detection of metastases and recurrences of colon carcinomas.
  
  
  METHODS
  A total of 45 patients with colon carcinoma was investigated with gamma camera, after intravenous application of iodinated monoclonal antibodies.
  
  
  RESULTS
  The sensitivity of the method was 90%, specificity 86%, positive predictive value 93%, negative predictive value 80% and accuracy 87%. There was statistically significant relationship between immunoscintigraphic and ultrasonographic (US) findings (p=0.005). Also, there was significant relationship between immunoscintigraphy and Dukes stage (p=0.019). Tumor marker levels were not significantly correlated with immunoscintigraphic findings (p<0.05). Significant difference was noted in patients with positive findings for malignancy on US and immunoscintigraphic findings (p=0.006), i.e. patients with positive findings for malignancy had more frequently immunoscintigraphic findings of malignancy. Correlation with other diagnostic procedures (rectoscopy, colonoscopy, CT) did not show significant correlations.
  
  
  CONCLUSIONS
  We conclude that immunoscintigraphy can be helpful in the detection of metastases and recurrences of colon carcinomas.
authors: Center of Nuclear Medicine, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. veraart@beotel.rs
authors: V
authors: V
authors: Artiko
authors: M
authors: M
authors: Petrovic
authors: Z
authors: Z
authors: Jankovic
authors: Lj
authors: Lj
authors: Jaukovic
authors: D
authors: D
authors: Sobic-Saranovic
authors: I
authors: I
authors: Grozdic
authors: S
authors: S
authors: Odalovic
authors: S
authors: S
authors: Pavlovic
authors: E
authors: E
authors: Jaksic
authors: M
authors: M
authors: Zuvela
authors: B
authors: B
authors: Ajdinovic
authors: S
authors: S
authors: Matic
authors: V
authors: V
authors: Obradovic
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D016719:Radioimmunodetection / Q000379:methods*
chemical_list: D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes