title: [Experimental correlation study of lumbar spinal stenosis and knee joint degeneration].
abstract: OBJECTIVE
  To explore the correlation of lumbar stenosis and knee osteoarthritis by establishing a rabbit lumbar spinal stenosis model and observing the hind limb movement function and pathological change of articular cartilage of knee joint.
  
  
  METHODS
  A total of 36 healthy adult rabbits were randomly divided into model group and control group. In the model group, spinal canal was filled with bone pieces to make lumbar spinal stenosis; in the control group, sham operation was performed and materials were inserted into spinal canal. Movement function was evaluated by Tarlov method and pathological features were observed by Mankin's scores under light microscope at 4, 8 and 12 weeks.
  
  
  RESULTS
  Early degenerative changes of knee cartilage were observed in the model group at 4 and 8 weeks post-operation. There were synovial hyperemia and hyperplasia, increased synovial fluid effusion and lightly-stained cartilage. The Mankin score was 3.3 - 4.5 and Tarlov score 3 - 4. Intermediate stage changes of osteoarthritis were found in the model group at 12 weeks post-operation, showing synovial hyperplasia, decreased synovial fluid, fissure in cartilage surface, tangled cartilage cells and unevenly stained matrix. The Mankins score was 7 - 9 and Tarlov score 2 - 3. Most of articular cartilage was normal in the control group with Mankin score of 0 - 1 and Tarlov score of 4.
  
  
  CONCLUSIONS
  Lumbar stenosis may be correlated with knee joint degeneration.
authors: Department of Spinal Surgery, Peking University People's Hospital, Beijing, China.
authors: Ke-nan
authors: KN
authors: Miu
authors: Hai-ying
authors: HY
authors: Liu
authors: Sheng-guo
authors: SG
authors: Zhang
authors: Zhen-qi
authors: ZQ
authors: Zhu
authors: Ya-long
authors: YL
authors: Qian
authors: Bo
authors: B
authors: Wang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007719:Knee Joint / Q000473:pathology; D008159:Lumbar Vertebrae / Q000473:pathology; D020370:Osteoarthritis, Knee / Q000473:pathology; D011817:Rabbits; D013130:Spinal Stenosis / Q000473:pathology