title: Bioinformatics analysis reveals potential candidate drugs for HCC.
abstract: In our study, we used the GSE17967 series to identify differentially expressed genes between cirrhosis and hepatocellular carcinoma, aiming to analyse the mechanism of the progression of cirrhosis to hepatocellular carcinoma and identify the sub-pathways closely related to this progression, and find the small molecule drugs to interfere this progression. From the result of our study, we find that many small molecule drugs closely related with carcinoma have been linked by our method. We also find some new small molecule drugs related to this progression. It is demonstrated that bioinformatics analysis is useful in identification of the candidate drugs in hepatocellular carcinoma.
authors: Department of Hepatobiliary Surgery, Xinqiao Hospital, Third Military Medical University, 400037, NO.2 Xin Qiao Street, Sha Ping Ba District, Chongqing, People's Republic of China.
authors: Xiao-Bing
authors: XB
authors: Huang
authors: Jing
authors: J
authors: Li
authors: Lu
authors: L
authors: Zheng
authors: Guo-Hua
authors: GH
authors: Zuo
authors: Ke-Qiang
authors: KQ
authors: Han
authors: Hong-Yan
authors: HY
authors: Li
authors: Ping
authors: P
authors: Liang
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D019295:Computational Biology / Q000379:methods; D018450:Disease Progression; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D060066:Protein Interaction Maps; D054852:Small Molecule Libraries / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D054852:Small Molecule Libraries