title: [Clinicopathologic and cytogenetic features of 114 Chinese mantle cell lymphoma cases].
abstract: OBJECTIVE
  To study the clinicopathologic features, immunotype and cytogenetics of Chinese mantle cell lymphoma (MCL).
  
  
  METHODS
  114 MCL cases were collected from hematopathology lab of department of pathology, Peking University, HSC. Routine HE stain and immune stain were used to investigate the clinicopathologic features and immune type. Breaks of CCND1 and IgH/CCND1 fusion genes were detected by FISH.
  
  
  RESULTS
  The ratio of male to female was 3.56:1 (89:25) with the median age of 60 years old (20 - 83 years old). 78 cases (68.42%, 78/114) primarily showed lymph node involvement, including 49 cases (49/78, 62.82%) jugular node involvement; 36 cases (31.58%, 36/114) showed extra-nodal involvement. 23 cases (23/114, 20.18%)showed bone marrow involvement. The expressions of CD3ε, CD20, CD79a, PAX5, CD5, cyclinD1 and Bcl-2 were 0% (0/114), 99.12% (113/114), 96.43% (27/28), 97.56% (40/41), 67.89% (74/109), 100% (114/114) and 94.12% (48/51), respectively. Break of CCND1 gene was found in 20 cases (80%, 20/25), the fusion gene of IgH-CCND1 in 16 cases (80%, 16/20), the break of IgH gene in 9 cases (100%, 9/9)and its fusion gene in 8 cases (88.89%, 8/9). We followed up 75 cases with a period of 2-57 months. The median survival was 40.78 months. The survivals at 1 year, 2 year and 3 year were 84.13% (53/63), 68.09% (32/47) and 37.5% (12/32), respectively. The median survival of group with more than 40% expression of Ki-67 was 36 months, the group with less than 40% expression of Ki67 57 months (P = 0.003). 7 of 13 patients accepted Rituximab plus traditional chemotherapy attained CR, 3 cases PR. 11 of 44 cases accepted traditional chemotherapy attained CR, 9 cases PR (P = 0.052).
  
  
  CONCLUSIONS
  Most of Chinese MCL occurred in older male, multi-lymphadenopathy and bone marrow involvement were common in MCL as a aggressive tumor. High expression of Ki-67 was an adverse prognostic indicator. Rituximab could improve the survival. Change of CCND1 gene was the most common cytogenetic abnormality.
authors: Department of Pathology, Peking University, HSC, Beijing, China.
authors: Min
authors: M
authors: Li
authors: Xiao-Yan
authors: XY
authors: Wang
authors: Xue-Min
authors: XM
authors: Xue
authors: Cui-Ling
authors: CL
authors: Liu
authors: Xin
authors: X
authors: Huang
authors: Lin
authors: L
authors: Sun
authors: Zi-Fen
authors: ZF
authors: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D019938:Cyclin D1 / Q000235:genetics; D003582:Cytogenetics; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000235:genetics; D020522:Lymphoma, Mantle-Cell / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
chemical_list: C530104:CCND1 protein, human; D019394:Ki-67 Antigen; D019938:Cyclin D1