title: An unusual case of giant cell myocarditis missed in a Heartmate-2 left ventricle apical-wedge section: a case report and review of the literature.
abstract: Herein we present a case of fulminant myocarditis in a woman previously treated for B-cell lymphoma. While the clinical context was suggestive of adriamycin-induced cardiomyopathy, the initial pathology of the Heartmate-2 apical core showed lymphocytic myocarditis. After 8 months of stability, the patient presented with progressive heart failure and recurrent ventricular arrhythmias. An endomyocardial biopsy revealed findings typical of giant cell myocarditis (GCM); poor response to immunosuppressive therapy and marked hemodynamic instability led to urgent transplantation. To our knowledge, this is the first reported case of GCM following an acute lymphocytic myocarditis and the second GCM case associated with B-cell lymphoma.
authors: Department of Medicine, Montreal Heart Institute, University of Montreal, 5000, Belanger East, Montreal, QC, H1T 1C8, Canada.
authors: Kim
authors: K
authors: Anderson
authors: Michel
authors: M
authors: Carrier
authors: Philippe
authors: P
authors: Romeo
authors: Guy B
authors: GB
authors: Pelletier
authors: Mark
authors: M
authors: Liszkowski
authors: Normand
authors: N
authors: Racine
authors: Michel
authors: M
authors: White
authors: Anique
authors: A
authors: Ducharme
mesh_terms: D000328:Adult; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D016027:Heart Transplantation; D006352:Heart Ventricles / Q000166:cytology / Q000473:pathology*; D006353:Heart-Assist Devices; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000473:pathology; D009205:Myocarditis / Q000473:pathology* / Q000601:surgery