title: Sequential Pd(0)-, Rh(I)-, and Ru(II)-catalyzed reactions in a nine-step synthesis of clinprost.
abstract: A step-economical synthesis of clinprost is reported that concludes with 3 different transition metal-catalyzed reactions: Pd-catalyzed decarboxylation with allylic rearrangement, Rh-catalyzed diene-ene [2+2+1] reaction, and Ru-catalyzed cross-metathesis reaction. The complexity bestowed to the molecule from these reactions converts a readily accessible ester to clinprost without using protecting groups in only 9 total steps.
authors: Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, USA.
authors: Emma E
authors: EE
authors: Nagy
authors: I F Dempsey
authors: IF
authors: Hyatt
authors: Kristen E
authors: KE
authors: Gettys
authors: Shawn T
authors: ST
authors: Yeazell
authors: Stephen K
authors: SK
authors: Frempong
authors: Mitchell P
authors: MP
authors: Croatt