title: Palladium catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol.
abstract: We report efficient Pd-catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes as the basis of a general entry to α,α-disubstituted pyrrolidine derivatives. We also demonstrate that catalytic asymmetric variants of this chemistry are feasible by employing a suitable chiral ligand.
authors: School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.
authors: Adele
authors: A
authors: Faulkner
authors: James S
authors: JS
authors: Scott
authors: John F
authors: JF
authors: Bower
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004952:Esters; D010091:Oximes / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D004952:Esters; D010091:Oximes; D011759:Pyrrolidines; D010165:Palladium; C032519:pyrrolidine