title: Pharmacokinetic study of azithromycin with fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole) in healthy volunteers.
abstract: BACKGROUND
  Azithromycin, fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole; TMP/SMX) are all agents that are utilised for the treatment and/or prophylaxis of opportunistic infections in patients with AIDS.
  
  
  OBJECTIVE
  To characterise the potential for an interaction when azithromycin is coadministered with cotrimoxazole or with fluconazole.
  
  
  METHODS
  Two separate nonblind randomised studies were conducted in healthy volunteers. During the fluconazole study the potential for fluconazole to adversely affect the pharmacokinetics of azithromycin was also studied.
  
  
  METHODS
  24 (cotrimoxazole) and 18 (fluconazole) healthy male and female volunteers.
  
  
  RESULTS
  The results of both studies indicated that neither the peak concentrations of nor the exposures (area under the concentration-time curve) to the test drugs were changed when azithromycin was coadministered. In addition, fluconazole did not significantly alter the pharmacokinetic parameters of azithromycin.
  
  
  CONCLUSIONS
  Azithromycin does not alter the bioavailability of either cotrimoxazole or fluconazole.
authors: The Clinical Pharmacology Research Center, Research Institute and Departments of Pharmacy and Medicine, Bassett Healthcare, Cooperstown, New York, USA, guy.amsden@bassett.org.
authors: G W
authors: GW
authors: Amsden
authors: G
authors: G
authors: Foulds
authors: K
authors: K
authors: Thakker