title: Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase.
abstract: Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O(2)(˙-) disproportionation, and exhibit impressive Ni-SOD activity.
authors: Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
authors: Yi
authors: Y
authors: Liu
authors: Qingli
authors: Q
authors: Wang
authors: Yaozhu
authors: Y
authors: Wei
authors: Ying-Wu
authors: YW
authors: Lin
authors: Wei
authors: W
authors: Li
authors: Ji-Hu
authors: JH
authors: Su
authors: Zhen
authors: Z
authors: Wang
authors: Yang
authors: Y
authors: Tian
authors: Zhong-Xian
authors: ZX
authors: Huang
authors: Xiangshi
authors: X
authors: Tan
mesh_terms: D019943:Amino Acid Substitution; D003066:Coenzyme A Ligases / Q000737:chemistry* / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D011789:Quantum Theory; D013482:Superoxide Dismutase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D013481:Superoxides / Q000737:chemistry
chemical_list: D013481:Superoxides; D009532:Nickel; D013482:Superoxide Dismutase; D003066:Coenzyme A Ligases