title: Expression of candidate plasticity-related gene 15 is increased following traumatic brain injury.
abstract: OBJECTIVE
  Candidate plasticity-related gene 15 (cpg15) is an activity-regulated gene that mediates synaptic plasticity; this study assesses the potential link between cpg15 expression levels and repair and regeneration following traumatic brain injury (TBI).
  
  
  METHODS
  We investigated the expression of cpg15 in the frontal lobe of rats subjected to TBI and sham rats, using the following methods: immunohistochemical analysis, Western blotting, and reverse transcription-polymerase chain reaction.
  
  
  RESULTS
  CPG15(+) neurons were present in coronal sections of the frontal lobe at Day 1, reached the highest level around Day 14, and maintained elevated levels through Day 21. CPG15 protein and mRNA levels were noticed to increase in a similar temporal pattern. In contrast, rats in the sham group had undetectable levels of CPG15.
  
  
  CONCLUSIONS
  Elevated cpg15 expression in the frontal cortex suggests its possible involvement in regenerative and reparative processes that follow TBI.
authors: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Yalong
authors: Y
authors: He
authors: Guitao
authors: G
authors: Yang
authors: Yangang
authors: Y
authors: Wang
authors: Yi
authors: Y
authors: Ren
authors: Xiaosheng
authors: X
authors: He
authors: Xiang
authors: X
authors: Zhang
authors: Zhou
authors: Z
authors: Fei
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000235:genetics*; D005625:Frontal Lobe / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D055495:Neurogenesis / Q000235:genetics; D009474:Neurons / Q000378:metabolism; D051381:Rats; D015854:Up-Regulation
chemical_list: C114622:Cpg15 protein, rat; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins