title: Detection of brain metastases by 3-dimensional magnetic resonance imaging at 3 T: comparison between T1-weighted volume isotropic turbo spin echo acquisition and 3-dimensional T1-weighted fluid-attenuated inversion recovery imaging.
abstract: OBJECTIVE
  This study aimed to compare the diagnostic performance in the detection of brain metastases between contrast-enhanced T1-weighted volume isotropic turbo spin echo acquisition (T1-VISTA) and 3-dimensional T1-weighted fluid-attenuated inversion recovery (3D-T1-FLAIR) imaging at 3 T.
  
  
  METHODS
  Two neuroradiologists selected 129 true (metastases) and 70 false (vessels and artifacts) lesions on the contrast-enhanced T1-VISTA and 3D-T1-FLAIR images of 14 cancer patients with hyperintense brain lesions. Four blinded neuroradiologists distinguished between the true and false lesions, using a 5-point confidence rating scale. The receiver operating characteristic analysis was performed to compare the diagnostic performance. Contrast-to-noise ratio of the true lesions was also compared between the 2 sequences by using paired t tests.
  
  
  RESULTS
  For lesions less than 3 mm, the area under curve and sensitivity achieved by T1-VISTA imaging were significantly greater than 3D-T1-FLAIR imaging. The contrast-to-noise ratio was also significantly greater with T1-VISTA imaging.
  
  
  CONCLUSIONS
  The contrast-enhanced T1-VISTA imaging is better suited than 3D-T1-FLAIR imaging, for detection of small metastases.
authors: From the Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors: Atsushi
authors: A
authors: Yoshida
authors: Khin Khin
authors: KK
authors: Tha
authors: Noriyuki
authors: N
authors: Fujima
authors: Yuri
authors: Y
authors: Zaitsu
authors: Daisuke
authors: D
authors: Yoshida
authors: Akiko
authors: A
authors: Tsukahara
authors: Shunsuke
authors: S
authors: Onodera
authors: Hiroki
authors: H
authors: Shirato
authors: Satoshi
authors: S
authors: Terae
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D016477:Artifacts; D001932:Brain Neoplasms / Q000556:secondary; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006571:Heterocyclic Compounds; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; C064925:gadodiamide; D005682:Gadolinium; D019786:Gadolinium DTPA