title: Effect of hyaluronate-endo-β-N-acetylhexosaminidase pegylated by electron beam synthesis nanotechnology on the formation of hematological shifts in chronic hepatitis.
abstract: We studied the effect of mobilization of bone marrow multipotent stem cells induced by intragastric administration of pegylated hyaluronate-endo-β-N-acetylhexosaminidase (Peg-HEAHA) on hemopoiesis under conditions of experimental chronic hepatitis. Peg-HEAHA increased the counts of hemopoietic precursors in the hemopoietic tissue against the background of their decelerated maturation. This was paralleled by a short-term decrease in the count of neutrophilic granulocyte in the bone marrow and a slight increase of neutrophil count in the peripheral blood.
authors: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors: A M
authors: AM
authors: Dygai
authors: G N
authors: GN
authors: Zyuz'kov
authors: R V
authors: RV
authors: Gurto
authors: V V
authors: VV
authors: Zhdanov
authors: E V
authors: EV
authors: Udut
authors: L A
authors: LA
authors: Miroshnichenko
authors: E V
authors: EV
authors: Simanina
authors: L A
authors: LA
authors: Stavrova
authors: A V
authors: AV
authors: Chaikovskii
authors: T S
authors: TS
authors: Markova
authors: M Yu
authors: MY
authors: Minakova
authors: A V
authors: AV
authors: Artamonov
authors: A A
authors: AA
authors: Bekarev
authors: P G
authors: PG
authors: Madonov
authors: D N
authors: DN
authors: Kinsht
mesh_terms: D000818:Animals; D004583:Electrons; D006410:Hematopoiesis / Q000187:drug effects*; D006521:Hepatitis, Chronic / Q000188:drug therapy* / Q000378:metabolism; D006820:Hyaluronic Acid / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D036103:Nanotechnology / Q000379:methods; D044968:Regenerative Medicine / Q000379:methods; D001619:beta-N-Acetylhexosaminidases / Q000737:chemistry*
chemical_list: D006820:Hyaluronic Acid; D001619:beta-N-Acetylhexosaminidases