title: Skin regeneration after chemical burn under the effect of taxifolin-based preparations.
abstract: We studied the effect of liposome preparation containing taxifolin oligomers and taxifolin conjugates with carbonyl compounds on skin regeneration after chemical burn. The preparations containing flavonoid conjugates intensified regeneration processes and reparation of hair follicles and sebaceous glands after chemical burn. The preparation based on taxifolin conjugate with acetaldehyde was most effective; its activity was comparable with that of the wound-healing preparation Olasol. Taxifolin conjugates with carbonyl compounds can be used for the creation of combined wound- and burn-healing preparations.
authors: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia. shubinavictoria@rambler.ru
authors: V S
authors: VS
authors: Shubina
authors: Yu V
authors: YV
authors: Shatalin
mesh_terms: D000079:Acetaldehyde / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D002057:Burns, Chemical / Q000188:drug therapy*; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use; D018859:Hair Follicle / Q000187:drug effects / Q000254:growth & development; D008081:Liposomes; D008297:Male; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects*; D012627:Sebaceous Glands / Q000187:drug effects / Q000254:growth & development; D012867:Skin / Q000254:growth & development* / Q000293:injuries* / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects
chemical_list: D005419:Flavonoids; D008081:Liposomes; D011794:Quercetin; C003377:taxifolin; D000079:Acetaldehyde