title: Urinary levels of regenerating protein Iα do not differentiate celiac patients and healthy subjects.
abstract: Celiac disease is an autoimmune disorder induced by gluten in genetically predisposed people. The discovery of new biomarkers may help in the diagnosis and follow-up of celiac patients. Regenerating islet-derived 1 alpha (REGIα)--a biomarker related to tissue regeneration--is increased in serum at the onset of the disease, decreasing after gluten-free diet (GFD). As REGIα is a 18 kDa soluble glycoprotein, it may be detected in urine samples, increasing in celiac patients. We have determined REGIα levels by ELISA. No differences were found among patients (onset or after GFD) and controls and no correlation exists among REGIα in sera and urine.
authors: Laboratory of Immunobiology for Research and Diagnosis Applications (LIRAD), Blood and Tissue Bank, Germans Trias i Pujol Research Institute, Badalona, Spain.
authors: Estíbaliz
authors: E
authors: Ruíz-Ortiz
authors: Agustín L
authors: AL
authors: Santos
authors: Irma
authors: I
authors: Pujol-Autonell
authors: Raquel
authors: R
authors: Planas
authors: Montserrat
authors: M
authors: Montraveta
authors: Guillem
authors: G
authors: Pintos
authors: Maria
authors: M
authors: Doladé
authors: Eduard
authors: E
authors: Cabré
authors: Marta
authors: M
authors: Vives-Pi
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D016022:Case-Control Studies; D002446:Celiac Disease / Q000097:blood* / Q000175:diagnosis / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D051847:Lithostathine / Q000097:blood* / Q000652:urine*; D008297:Male
chemical_list: D015415:Biomarkers; D051847:Lithostathine; C497617:REG1A protein, human