title: Mitochondrial dysfunction and the inflammatory response.
abstract: Inflammation has been linked to multiple degenerative and acute diseases as well as the aging process. Moreover, mitochondrial alterations play a central role in these processes. Mitochondria have an important role in pro-inflammatory signaling; similarly, pro-inflammatory mediators may also alter mitochondrial function. Both of these processes increase mitochondrial oxidative stress, promoting a vicious inflammatory cycle. Additionally, damage-associated molecular patterns derived from mitochondria could contribute to inflammasome formation and caspase-1 activation, while alterations in mitochondrial autophagy may cause inflammation. Strategies aimed at controlling excessive oxidative stress within mitochondria may represent both preventive and therapeutic interventions in inflammation.
authors: Aging and Inflammation Research Laboratory, Instituto de Investigación Biomédica A Coruña (INIBIC)-Complexo Hospitalario Universitario A Coruña (CHUAC)-SERGAS, Xubias 84, 15006, A Coruña, Spain. Maria.Jose.Lopez.Armada@sergas.es
authors: María J
authors: MJ
authors: López-Armada
authors: Romina R
authors: RR
authors: Riveiro-Naveira
authors: Carlos
authors: C
authors: Vaamonde-García
authors: Marta N
authors: MN
authors: Valcárcel-Ares
mesh_terms: D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D018384:Oxidative Stress