title: XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells.
abstract: X-chromosome inactivation (XCI) in mammals relies on XIST, a long noncoding transcript that coats and silences the X chromosome in cis. Here we report the discovery of a long noncoding RNA, XACT, that is expressed from and coats the active X chromosome specifically in human pluripotent cells. In the absence of XIST, XACT is expressed from both X chromosomes in humans but not in mice, suggesting a unique role for XACT in the control of human XCI initiation.
authors: Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, Paris, France.
authors: Céline
authors: C
authors: Vallot
authors: Christophe
authors: C
authors: Huret
authors: Yann
authors: Y
authors: Lesecque
authors: Alissa
authors: A
authors: Resch
authors: Noufissa
authors: N
authors: Oudrhiri
authors: Annelise
authors: A
authors: Bennaceur-Griscelli
authors: Laurent
authors: L
authors: Duret
authors: Claire
authors: C
authors: Rougeulle
mesh_terms: D000818:Animals; D041321:Chromosomes, Human, X; D004303:Dosage Compensation, Genetic; D006801:Humans; D051379:Mice; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D049951:X Chromosome Inactivation / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding; D014157:Transcription Factors; C077885:XIST non-coding RNA; C000621435:long non-coding RNA XACT, human