title: An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor.
abstract: We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor.
authors: Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan.
authors: Keiichi
authors: K
authors: Yoshikawa
authors: Hiroaki
authors: H
authors: Nakagawa
authors: Naoki
authors: N
authors: Mori
authors: Hidenori
authors: H
authors: Watanabe
authors: Kazushige
authors: K
authors: Touhara
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000652:urine; D005088:Exocrine Glands / Q000378:metabolism; D005233:Fatty Alcohols / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D005260:Female; D008024:Ligands; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018035:Receptors, Odorant / Q000378:metabolism*
chemical_list: C580997:5-tetradecen-1-ol; D001688:Biological Products; D005233:Fatty Alcohols; D008024:Ligands; D018035:Receptors, Odorant