title: Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.
authors: Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China.
authors: Xinwang
authors: X
authors: Chen
authors: Xiao
authors: X
authors: Jia
authors: Jie
authors: J
authors: Qiao
authors: Youfei
authors: Y
authors: Guan
authors: Jihong
authors: J
authors: Kang
mesh_terms: D000209:Acute-Phase Proteins / Q000235:genetics / Q000378:metabolism; D054392:Adipokines / Q000235:genetics / Q000378:metabolism*; D018925:Chemokines / Q000235:genetics / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D037102:Lectins / Q000235:genetics / Q000378:metabolism; D020738:Leptin / Q000235:genetics / Q000378:metabolism; D000071068:Lipocalin-2; D054834:Lipocalins / Q000235:genetics / Q000378:metabolism; D054409:Nicotinamide Phosphoribosyltransferase / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000235:genetics / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000235:genetics / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D052243:Resistin / Q000235:genetics / Q000378:metabolism; D054839:Retinol-Binding Proteins, Plasma / Q000235:genetics / Q000378:metabolism
chemical_list: D000209:Acute-Phase Proteins; D054392:Adipokines; D018925:Chemokines; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; C489506:LCN2 protein, human; D037102:Lectins; D020738:Leptin; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; C478630:RARRES2 protein, human; C101326:RBP4 protein, human; D052243:Resistin; D054839:Retinol-Binding Proteins, Plasma; D054409:Nicotinamide Phosphoribosyltransferase