title: Serum levels of heat shock protein 27 in patients with acute ischemic stroke.
abstract: Expression of intracellular heat shock protein 27 (Hsp27) rises in the brain of animal models of cerebral ischemia and stroke. Hsp27 is also released into the circulation and the aim of the present study was to investigated if serum Hsp27 (sHsp27) levels are altered in patients with acute ischemic stroke. sHsp27 was measured in 15 patients with acute ischemic stroke and in 14 control subjects comparable for age, sex, and cardiovascular risk factors. In patients, measurements were performed at admission and 1, 2, and 30 days thereafter. At admission, mean sHsp27 values were threefold higher in patients than in controls. In patients, sHsp27 values dropped after 24 h, rose again at 48 h, and markedly declined at 30 days, indicating the presence of a temporal trend of sHsp27 values following acute ischemic stroke.
authors: Department of Medical Science, University of Turin, Corso Dogliotti 14, Turin, Italy. gabriella.gruden@unito.it
authors: Gabriella
authors: G
authors: Gruden
authors: Federica
authors: F
authors: Barutta
authors: Irene
authors: I
authors: Catto
authors: Giovanni
authors: G
authors: Bosco
authors: Maria Giovanna
authors: MG
authors: Caprioli
authors: Silvia
authors: S
authors: Pinach
authors: Paolo
authors: P
authors: Fornengo
authors: Paolo
authors: P
authors: Cavallo-Perin
authors: Ottavio
authors: O
authors: Davini
authors: Paolo
authors: P
authors: Cerrato
authors: Graziella
authors: G
authors: Bruno
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000209:etiology; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D055551:HSP27 Heat-Shock Proteins