title: Comparison of high spatial resolution respiratory triggered inversion recovery-prepared spoiled gradient echo sequence with standard breathhold T1 sequence MRI of the liver using gadoxetic acid.
abstract: OBJECTIVE
  To assess if a high resolution respiratory triggered inversion recovery prepared GRE sequence (RT) improved image quality and detection of lesions compared with breathhold GRE T1 weighted MR sequence (BH) in the hepatobiliary uptake phase of MR of the liver using gadoxetic acid (Gd-EOB-DTPA).
  
  
  METHODS
  Thirty-eight consecutive patients from July 2009 to September 2010 who had undergone Gd-EOB-DTPA enhanced liver exams were retrospectively identified. Qualitative assessment performed on reference lesions and background liver by two independent readers. Quantitative assessment performed by one reader.
  
  
  RESULTS
  Liver parenchyma signal-to-noise ratio for BH was 90.3 ± 23.9 (mean ± SD) and RT, 106.1 ± 40.4 (P = 0.119). For BH, 320 lesions were detected compared with 257 for RT. Lesion to liver contrast was significantly better on RT sequences (0.26 ± 0.24; mean ± SD) compared with BH sequence (0.21 ± 0.20; P = 0.044). Fifty-seven reference lesions assessed. Both reviewers rated BH better for lesion margin and hepatic vessel sharpness. BH was rated with less artifact (P < 0.05). Lesion to liver contrast on BH was significantly better for one reviewer.
  
  
  CONCLUSIONS
  BH sequence had better overall image quality than RT in several quantitative and qualitative factors including number of lesions detected and level of artifact.
authors: Department of Medical Imaging, University of Toronto, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada.
authors: Phillip V P
authors: PV
authors: Tran
authors: Kartik S
authors: KS
authors: Jhaveri
mesh_terms: D000328:Adult; D000368:Aged; D001659:Biliary Tract / Q000473:pathology; D005260:Female; D019786:Gadolinium DTPA / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012119:Respiration; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA