title: Revisiting bleomycin from pathophysiology to safe clinical use.
abstract: Bleomycin is a key component of curative chemotherapy regimens employed in the treatment of curable cancers, such as Hodgkin lymphoma (HL) and testicular germ-cell tumours (GCT), yet its use may cause bleomycin-induced lung injury (BILI), which is associated with significant morbidity and a mortality rate of 1-3%. Diagnosis of BILI is one of exclusion and physicians involved in the care of HL and GCT patients should be alerted. Pharmacogenomic studies could contribute towards the identification of molecular predictors of bleomycin toxicity on the aim to optimize individual use of bleomycin. We review all existing data on bleomycin's most recent integrated chemical biology, molecular pharmacology and mature clinical data and provide guidelines for its safe clinical use.
authors: Department of Pulmonology, Democritus University of Thrace, Greece.
authors: Marios
authors: M
authors: Froudarakis
authors: Eleftheria
authors: E
authors: Hatzimichael
authors: Lydia
authors: L
authors: Kyriazopoulou
authors: Konstantinos
authors: K
authors: Lagos
authors: Periklis
authors: P
authors: Pappas
authors: Andreas G
authors: AG
authors: Tzakos
authors: Vasilis
authors: V
authors: Karavasilis
authors: Danai
authors: D
authors: Daliani
authors: Christos
authors: C
authors: Papandreou
authors: Evangelos
authors: E
authors: Briasoulis
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001761:Bleomycin / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D055370:Lung Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D017410:Practice Guidelines as Topic; D012307:Risk Factors
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin