title: Efficacy and safety of oral low-dose glucocorticoids in patients with estrogen-dependent primary osteoarthritis.
abstract: Estrogen-dependent osteoarthritis (EDPOA) is a disease of perimenopausal-age women. Their manifestations are polyarticular pain with common co-morbidities (carpal tunnel syndrome, insomnia, fatigue, depression, and fibromyalgia). Based on dual role of glucocorticoids, its trophic action on the chondrocyte and its anti-inflammatory effect, we conducted a prospective interventional cohort study where we evaluate the efficacy and safety of oral low-dose GC in one hundred women with EDPOA. The pain intensity, number of tender joints as well as impact in co-morbidities were analyzed. We conclude that the use of low-dose GC in patients with EDPOA can be an effective and a safe therapeutic option.
authors: Rheumatology Unit, Fundación Valle del Lili, ICESI University, Cra. 98 18-49, Cali, Colombia, cacd12@hotmail.com.
authors: Carlos A
authors: CA
authors: Cañas
authors: Carlos J
authors: CJ
authors: Osorio
authors: Nicolás
authors: N
authors: Coronel
authors: Magda C
authors: MC
authors: Cepeda
authors: Jorge H
authors: JH
authors: Izquierdo
authors: Fabio
authors: F
authors: Bonilla-Abadía
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects; D015897:Comorbidity; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D010003:Osteoarthritis / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D047648:Perimenopause / Q000378:metabolism*; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D004967:Estrogens; D005938:Glucocorticoids