title: Hashimoto's thyroiditis concomitant with sequential autoimmune hepatitis, chorea and polyserositis: a new entity of autoimmune polyendocrine syndrome?
abstract: We herein report a case of Hashimoto's thyroiditis (HT) with sequential autoimmune hepatitis (AIH), chorea and polyserositis. The patient was a 24-year-old man who underwent subtotal thyroidectomy due to compression symptoms caused by goiter and was diagnosed with HT postoperatively based on pathological examinations two years previously. He had exhibited liver dysfunction and intermittent chorea since 2008. His liver function and polyserositis improved remarkably following the administration of ursodeoxycholic acid (UDCA) and methylprednisolone. This is a very rare case that can be classified as autoimmune polyglandular syndrome (APS) type 3. Early and adequate UDCA and glucocorticoid treatment may lead to a favorable prognosis.
authors: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, China.
authors: Haoyong
authors: H
authors: Yu
authors: Huiling
authors: H
authors: Qiu
authors: Jiemin
authors: J
authors: Pan
authors: Shenqi
authors: S
authors: Wang
authors: Yuqian
authors: Y
authors: Bao
authors: Weiping
authors: W
authors: Jia
mesh_terms: D002819:Chorea / Q000150:complications / Q000175:diagnosis*; D050031:Hashimoto Disease / Q000150:complications / Q000175:diagnosis*; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D012700:Serositis / Q000150:complications / Q000175:diagnosis*; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000175:diagnosis*; D055815:Young Adult