title: [Minocycline-induced autoimmune hepatitis].
abstract: BACKGROUND
  Drug-induced autoimmune hepatitis is an acute and potentially severe side effect, particularly often reported after the long-term use of minocycline. The condition's characteristic biochemical findings are highly elevated transaminase levels, only mildly increased markers of cholestasis and bilirubin levels, an elevated IgG concentration and a high antinuclear antibody (ANA) titre.
  
  
  METHODS
  A 14-year-old girl developed autoimmune hepatitis due to the long-term use of minocycline for acne vulgaris. She presented with icterus and very high transaminase levels. The patient made a full recovery after the medication was discontinued.
  
  
  CONCLUSIONS
  This type of autoimmune hepatitis can be differentiated from 'classic' autoimmune hepatitis by the patient's quick recovery after stopping the inducing drug and no relapse of the condition after the discontinuation of glucocorticoid therapy.
authors: Ziekenhuis Gelderse Vallei, afd. Kindergeneeskunde, Ede, the Netherlands. aldenhovenm@zgv.nl
authors: Mieke
authors: M
authors: Aldenhoven
authors: J Gert
authors: JG
authors: van Enk
authors: Wim A
authors: WA
authors: Avis
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000974:Antibodies, Antinuclear / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology; D005260:Female; D019693:Hepatitis, Autoimmune / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008911:Minocycline / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D008911:Minocycline