title: Determination of preservatives in cosmetics, cleaning agents and pharmaceuticals using fast liquid chromatography.
abstract: This paper reports the development of a method for simultaneously determining five preservatives in cosmetics, cleaning agents and pharmaceuticals by fast liquid chromatography. Methylisothiazolinone, methylchloroisothiazolinone, benzyl alcohol, sodium benzoate and methylparaben were separated on a Chromolith Fast Gradient reversed-phase 18e column using gradient elution with acetonitrile and a 0.1% aqueous solution of formic acid, with a run time of 3 min. The preparation of solid and liquid samples included ultrasonic extraction with methanol with recoveries ranging from 69 to 119%. The developed method was used to analyze samples of cosmetics (66 samples), cleaning agents (five samples) and pharmaceutical industry products (17 samples).
authors: Department of Analytical Chemistry, Chemical Faculty, Silesian University of Technology, 7 M. Strzody Str, 44-100 Gliwice, Poland.
authors: Irena
authors: I
authors: Baranowska
authors: Iwona
authors: I
authors: Wojciechowska
authors: Natalia
authors: N
authors: Solarz
authors: Ewa
authors: E
authors: Krutysza
mesh_terms: D019905:Benzyl Alcohol / Q000032:analysis / Q000737:chemistry; D002853:Chromatography, Liquid / Q000379:methods*; D003358:Cosmetics / Q000737:chemistry*; D003902:Detergents / Q000737:chemistry*; D057230:Limit of Detection; D016014:Linear Models; D010226:Parabens / Q000032:analysis / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011310:Preservatives, Pharmaceutical / Q000032:analysis* / Q000737:chemistry; D015203:Reproducibility of Results; D020160:Sodium Benzoate / Q000032:analysis / Q000737:chemistry; D013844:Thiazoles / Q000032:analysis / Q000737:chemistry
chemical_list: D003358:Cosmetics; D003902:Detergents; D010226:Parabens; D004364:Pharmaceutical Preparations; D011310:Preservatives, Pharmaceutical; D013844:Thiazoles; C015358:methylparaben; D019905:Benzyl Alcohol; D020160:Sodium Benzoate