title: Adrenomedullin facilitates calcium channel currents in osteoblasts.
abstract: Osteoblasts play a major role in bone formation. Osteoblasts employ intracellular Ca(2+) as a second messenger to modulate hormonal responses and a cofactor for bone mineralization. Adrenomedullin (ADM) promotes osteoblast growth and proliferation, inducing an increase in bone mass. Voltage-dependent Ca(2+) channels (VDCCs) mediate the influx of Ca(2+) in response to membrane depolarization. Voltage-dependent Ca(2+) channels serve as crucial mediators of many Ca(2+)-dependent functions, including growth of bone and regulation of proliferation. The purpose of this study was to investigate the effects of ADM on VDCC currents in osteoblasts using a patch-clamp recording method. To our knowledge, the data presented here demonstrate for the first time that ADM facilitates VDCCs in osteoblasts.
authors: Department of Physiology, Tokyo Dental College, Chiba, Japan.
authors: Masakazu
authors: M
authors: Tazaki
authors: Takayuki
authors: T
authors: Endoh
authors: Hiroshi
authors: H
authors: Kobayashi
authors: Hiromi
authors: H
authors: Nobushima
authors: Yoshiyuki
authors: Y
authors: Shibukawa
authors: Maki
authors: M
authors: Tsumura
authors: Masaki
authors: M
authors: Sato
authors: Sobhan
authors: S
authors: Ubaidus
authors: Kenji
authors: K
authors: Sueishi
mesh_terms: D053607:Adrenomedullin / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000187:drug effects* / Q000378:metabolism; D002460:Cell Line; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects* / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D018408:Patch-Clamp Techniques; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D020746:Calcium Channels, L-Type; D014665:Vasodilator Agents; D053607:Adrenomedullin; D002118:Calcium