title: [Study on the chemical components, antimicrobial and antitumor activities of the essential oil from the leaves of Zanthoxylum avicennae].
abstract: OBJECTIVE
  To study the chemical constituents, antimicrobial activity and antitumor activity of the essential oil from Zanthoxylum avicennae.
  
  
  METHODS
  The essential oil from the leaves of Zanthoxylum avicennae was extracted by steam distillation. The components of the essential oil were separated and identified by GC-MS.
  
  
  RESULTS
  72 components were identified and accounted for 98.15% of the all peak area. The essential oil exhibited strong antitumor activity against K-562 human tumor cell lines with IC50 of 1.76 microg/mL. It also exhibited moderate antimicrobial activity against three bacteria.
  
  
  CONCLUSIONS
  The essential oil of Zanthoxylum avicennae contains various active constituents. This result provides scientific reference for the pharmacological further research of Zanthoxylum avicennae.
authors: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Haikou 571158, China.
authors: Da-Shuai
authors: DS
authors: Zhang
authors: Qiong-Xin
authors: QX
authors: Zhong
authors: Xin-Ming
authors: XM
authors: Song
authors: Wen-Jie
authors: WJ
authors: Liu
authors: Jing
authors: J
authors: Wang
authors: Qiong-Yu
authors: QY
authors: Zhang
mesh_terms: D000080462:Acyclic Monoterpenes; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D020128:Inhibitory Concentration 50; D039821:Monoterpenes / Q000032:analysis / Q000494:pharmacology; D009822:Oils, Volatile / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000032:analysis / Q000494:pharmacology; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D000080462:Acyclic Monoterpenes; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D039821:Monoterpenes; D009822:Oils, Volatile; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C445979:beta-elemene; C018584:linalool; C515179:caryophyllene oxide