title: A case-control study on excessive daytime sleepiness in chronic migraine.
abstract: BACKGROUND
  Excessive daytime sleepiness is a major clinical and health concern that can have varied and sometimes harmful consequences. Findings from uncontrolled studies suggest a high prevalence in patients with chronic migraine.
  
  
  METHODS
  In a case-control study, we compared frequency data for excessive daytime sleepiness in 100 patients with chronic migraine and 100 healthy controls paired for sex and age, and assessed risk factors including lifestyle, sleep quality, anxiety, depression, concomitant disease and medications.
  
  
  RESULTS
  The frequency of excessive daytime sleepiness was higher in migraineurs (especially in those with medication overuse) than in controls (20% versus 6%; odds ratio 3.92, 95% CI 1.5-10.22), but was lower than previously reported and correlated with poor quality sleep and anxiolytic and antidepressant use.
  
  
  CONCLUSIONS
  Again confirming that disability in chronic migraine is multifactorial in origin, excessive daytime sleepiness, especially in migraineurs who overuse medications, adds to the multiple factors known to impair social and working function. Patients with chronic migraine might benefit from diagnostic interviews focussing also on sleep problems and from targeted psychoactive drug prescribing.
authors: Headache and Pain Unit, IRCCS San Raffaele Pisana, Via della Pisana 235, 00163 Rome, Italy. piero.barbanti@sanraffaele.it
authors: Piero
authors: P
authors: Barbanti
authors: Cinzia
authors: C
authors: Aurilia
authors: Gabriella
authors: G
authors: Egeo
authors: Luisa
authors: L
authors: Fofi
authors: Nicola
authors: N
authors: Vanacore
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000453:epidemiology; D016022:Case-Control Studies; D002908:Chronic Disease; D003866:Depressive Disorder / Q000453:epidemiology; D004185:Disability Evaluation; D006970:Disorders of Excessive Somnolence / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D012890:Sleep