title: Juxtapapillary pigment epithelium detachment observed in asymptomatic participants using optical coherence tomography.
abstract: OBJECTIVE
  To use three-dimensional optical coherence tomography (3D-OCT) to assess the prevalence of juxtapapillary retinal pigment epithelial detachments (jPED) in an asymptomatic population.
  
  
  METHODS
  Asymptomatic participants (i.e., family members of patients) were prospectively recruited over a 6-month period. Each subject completed a questionnaire prior to the acquisition of two undilated 45° fundus images and two undilated raster 3D-OCT scans (512 × 128) covering the macula and optic nerve from each eye using 3D-OCT-1000. Fundus images were graded for the presence of peripapillary atrophy (PPA), peripapillary pigment (PPP), drusen in the macula, and drusen elsewhere, whereas 3D-OCT scans were assessed for the presence of jPED, drusen in the macula, and drusen elsewhere.
  
  
  RESULTS
  In all, 276 eyes from 138 participants were evaluated. Mean participant age was 37.6 years (range: 18-74 years; SD: 15.5 years). In all, 87 jPEDs were detected in 26.1% (36/138) of asymptomatic participants (25 bilateral and 11 unilateral) or 17.0% (47/276) of asymptomatic eyes (23 in the right eye and 24 in the left). The maximum height of jPED was 198.3 ± 53.8 (range: 101.8-376.0) μm. The minimum distance of jPED to the border of optic nerve head (OPN) was 2.6 ± 11.1 (range: 0-61.9) μm. The occurrence of jPEDs or drusen elsewhere by subjects increased statistically with increasing age (P < 0.001, respectively).
  
  
  CONCLUSIONS
  In this study, definite jPEDs were observed by OCT in asymptomatic participants, which were not seen with fundus photography. jPEDs were seen more commonly with increasing age, although it is not known whether these lesions represent deposition of drusen-like material or aborted choroidal neovascularization adjacent to the natural break in Bruch's membrane at the optic disc.
authors: Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors: Yanling
authors: Y
authors: Ouyang
authors: Florian M
authors: FM
authors: Heussen
authors: Pearse A
authors: PA
authors: Keane
authors: Rajeev K R
authors: RK
authors: Pappuru
authors: Srinivas R
authors: SR
authors: Sadda
authors: Alexander C
authors: AC
authors: Walsh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases / Q000453:epidemiology*; D016570:Bruch Membrane / Q000473:pathology; D020256:Choroidal Neovascularization / Q000453:epidemiology / Q000473:pathology; D015785:Eye Diseases, Hereditary / Q000453:epidemiology / Q000473:pathology; D005190:Family; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015594:Optic Disk Drusen / Q000453:epidemiology / Q000473:pathology; D015995:Prevalence; D012163:Retinal Detachment / Q000453:epidemiology* / Q000473:pathology*; D041623:Tomography, Optical Coherence; D055815:Young Adult