title: A verocytotoxin-producing E. coli outbreak with a surprisingly high risk of haemolytic uraemic syndrome, Denmark, September-October 2012.
abstract: Denmark faced an outbreak of verocytotoxin-producing E. coli (VTEC) O157:H7 infections in autumn 2012. Thirteen cases were diagnosed of which eight had haemolytic uraemic syndrome (HUS). Epidemiological investigations suggested ground beef as the vehicle of the outbreak. The outbreak strain had a rare toxin gene subtype profile: eae, vtx1a and vtx2a, and a high proportion of HUS (62%) among cases, a finding previously linked with the outbreak subtype profile. Toxin subtyping can be useful to identify high risk VTEC strains.
authors: Department of Infectious Disease Epidemiology, Statens Serum Institut, Copenhagen, Denmark. bot@ssi.dk
authors: B
authors: B
authors: Soborg
authors: S G
authors: SG
authors: Lassen
authors: L
authors: L
authors: Müller
authors: T
authors: T
authors: Jensen
authors: S
authors: S
authors: Ethelberg
authors: K
authors: K
authors: Mølbak
authors: F
authors: F
authors: Scheutz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D016358:Contact Tracing; D003718:Denmark / Q000453:epidemiology; D003967:Diarrhea / Q000382:microbiology; D004196:Disease Outbreaks; D016521:Electrophoresis, Gel, Pulsed-Field; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D005260:Female; D005838:Genotype; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D012307:Risk Factors; D022603:Shiga Toxins / Q000378:metabolism; D054323:Shiga-Toxigenic Escherichia coli / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D011795:Surveys and Questionnaires; D014774:Virulence; D055815:Young Adult
chemical_list: D022603:Shiga Toxins