title: Slower postnatal growth is associated with delayed cerebral cortical maturation in preterm newborns.
abstract: Slower postnatal growth is an important predictor of adverse neurodevelopmental outcomes in infants born preterm. However, the relationship between postnatal growth and cortical development remains largely unknown. Therefore, we examined the association between neonatal growth and diffusion tensor imaging measures of microstructural cortical development in infants born very preterm. Participants were 95 neonates born between 24 and 32 weeks gestational age studied twice with diffusion tensor imaging: scan 1 at a median of 32.1 weeks (interquartile range, 30.4 to 33.6) and scan 2 at a median of 40.3 weeks (interquartile range, 38.7 to 42.7). Fractional anisotropy and eigenvalues were recorded from 15 anatomically defined cortical regions. Weight, head circumference, and length were recorded at birth and at the time of each scan. Growth between scans was examined in relation to diffusion tensor imaging measures at scans 1 and 2, accounting for gestational age, birth weight, sex, postmenstrual age, known brain injury (white matter injury, intraventricular hemorrhage, and cerebellar hemorrhage), and neonatal illness (patent ductus arteriosus, days intubated, infection, and necrotizing enterocolitis). Impaired weight, length, and head growth were associated with delayed microstructural development of the cortical gray matter (fractional anisotropy: P < 0.001), but not white matter (fractional anisotropy: P = 0.529), after accounting for prenatal growth, neonatal illness, and brain injury. Avoiding growth impairment during neonatal care may allow cortical development to proceed optimally and, ultimately, may provide an opportunity to reduce neurological disabilities related to preterm birth.
authors: Neuroscience, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
authors: Jillian
authors: J
authors: Vinall
authors: Ruth E
authors: RE
authors: Grunau
authors: Rollin
authors: R
authors: Brant
authors: Vann
authors: V
authors: Chau
authors: Kenneth J
authors: KJ
authors: Poskitt
authors: Anne R
authors: AR
authors: Synnes
authors: Steven P
authors: SP
authors: Miller
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000627:therapeutic use; D016880:Anisotropy; D001724:Birth Weight / Q000187:drug effects; D002508:Cephalometry; D002540:Cerebral Cortex / Q000254:growth & development* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D048788:Growth and Development / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D047928:Premature Birth / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000305:Adrenal Cortex Hormones