title: Ischemia signalling to Alzheimer-related genes.
abstract: In this paper we review the hard-earned data, which present ischemic induction of amyloid precursor protein, presenilins, apolipoproteins and secretases genes, playing key roles in β-amyloid peptide generation. Presented data are strongly supporting a hypothesis that brain ischemia may be involved in the aetiology of sporadic Alzheimer's disease. Potential contribution and impact of ischemically activated genes on the development of sporadic Alzheimer's disease remain to be established at both genetic and functional levels. The identification of the genes involved in sporadic Alzheimer's disease induced by ischemia will enable to further define the events leading to Alzheimer's disease-related abnormalities. Additionally, knowledge gained from the reviewed studies should facilitate the elaboration of effective treatment and/or prevention of sporadic Alzheimer's disease.
authors: Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland. pluta@cmdik.pan.pl
authors: Ryszard
authors: R
authors: Pluta
authors: Janusz
authors: J
authors: Kocki
authors: Ryszard
authors: R
authors: Maciejewski
authors: Marzena
authors: M
authors: Ułamek-Kozioł
authors: Mirosław
authors: M
authors: Jabłoński
authors: Anna
authors: A
authors: Bogucka-Kocka
authors: Stanisław J
authors: SJ
authors: Czuczwar
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics* / Q000503:physiopathology; D000818:Animals; D002545:Brain Ischemia / Q000150:complications* / Q000503:physiopathology; D006801:Humans