title: Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa.
abstract: Biofilm formation by Pseudomonas aeruginosa has been implicated in the pathology of chronic wounds. Both the d and l isoforms of tryptophan inhibited P. aeruginosa biofilm formation on tissue culture plates, with an equimolar ratio of d and l isoforms producing the greatest inhibitory effect. Addition of d-/l-tryptophan to existing biofilms inhibited further biofilm growth and caused partial biofilm disassembly. Tryptophan significantly increased swimming motility, which may be responsible in part for diminished biofilm formation by P. aeruginosa.
authors: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors: Kenneth S
authors: KS
authors: Brandenburg
authors: Karien J
authors: KJ
authors: Rodriguez
authors: Jonathan F
authors: JF
authors: McAnulty
authors: Christopher J
authors: CJ
authors: Murphy
authors: Nicholas L
authors: NL
authors: Abbott
authors: Michael J
authors: MJ
authors: Schurr
authors: Charles J
authors: CJ
authors: Czuprynski
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D014364:Tryptophan / Q000494:pharmacology*
chemical_list: D014364:Tryptophan