title: Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals.
abstract: Bioactive glass has been shown to stimulate bone regeneration and soft tissue healing. In this study, we evaluated the local protective effects of bioactive glass on experimental gastric ulcers, in comparison with omeprazole and hydrotalcite. Single and multiple gavage of 45S5 bioactive glass dose-dependently protected stress ulcers in mice and chronic ulcers in rats. Multi-daily gavage of bioactive glass for 7 days prevented chronic ulcer recurrence by 50 %. Bioactive glass ionic dissolution produced marked proliferation of ethanol-injured GES-1 human gastric mucosa epithelial cells 48 and 72 h after exposure. Bioactive glass was shown to be hardly absorbed after single or multi-daily gavage. This study, for the first time, demonstrates that bioactive glass is effective in protecting against gastric ulcers, with its high efficacy comparable to omeprazole and superior to hydrotalcite. The lack of oral absorption makes bioactive glass a potential for treatment of peptic ulcers omitting systemic toxicity or side-effects.
authors: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
authors: Ai-niu
authors: AN
authors: Ma
authors: Nian
authors: N
authors: Gong
authors: Jin-miao
authors: JM
authors: Lu
authors: Jin-lu
authors: JL
authors: Huang
authors: Bin
authors: B
authors: Hao
authors: Yang
authors: Y
authors: Guo
authors: Jipin
authors: J
authors: Zhong
authors: Yuhong
authors: Y
authors: Xu
authors: Jiang
authors: J
authors: Chang
authors: Yong-xiang
authors: YX
authors: Wang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002460:Cell Line; D005753:Gastric Mucosa / Q000166:cytology; D005898:Glass; D006801:Humans; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D012008:Recurrence; D013276:Stomach Ulcer / Q000517:prevention & control*