title: [18F]fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): application to 6-[18F]fluoro-L-DOPA.
abstract: The Ag-mediated electrophilic [(18)F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [(18)F]selectfluor bis(triflate) in acetone. The process gave 6-[(18)F]fluoro-L-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol(-1).
authors: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
authors: Ida S R
authors: IS
authors: Stenhagen
authors: Anna K
authors: AK
authors: Kirjavainen
authors: Sarita J
authors: SJ
authors: Forsback
authors: Charlotte G
authors: CG
authors: Jørgensen
authors: Edward G
authors: EG
authors: Robins
authors: Sajinder K
authors: SK
authors: Luthra
authors: Olof
authors: O
authors: Solin
authors: Véronique
authors: V
authors: Gouverneur
mesh_terms: D000096:Acetone / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry*; D003979:Diazonium Compounds / Q000737:chemistry*; D004952:Esters; D005462:Fluorine Radioisotopes / Q000737:chemistry; D054879:Halogenation; D007980:Levodopa / Q000737:chemistry*; D012834:Silver / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D003979:Diazonium Compounds; D004952:Esters; D005462:Fluorine Radioisotopes; D000096:Acetone; D012834:Silver; D007980:Levodopa; C408750:selectfluor