title: Therapeutic guidelines on ulcerative colitis: a GRADE methodology based effort of GETECCU.
abstract: OBJECTIVE
  Evidence-based clinical guidelines on Ulcerative colitis (UC) have been developed through a consensus, while GRADE methodology is the current standard for guideline development. This is the first one based on GRADE methodology on UC.
  
  
  METHODS
  Following GRADE methodology, the Spanish Group of Ulcerative Colitis and Crohn's disease (GETECCU) have developed a guideline on UC treatment. After selection of relevant clinical scenarios, 32 clinical questions were chosen and recommendations were established.
  
  
  RESULTS
  In 2 questions no recommendation was possible. Twenty-two actions were recommended for, 14 strongly and 8 weakly. However, in 8 questions a recommendation against doing something was obtained, weak in 5 and strong in 3. The majority of recommendations were based on moderate quality evidence, and only 5 on high-quality evidence.
  
  
  CONCLUSIONS
  With GRADE methodology we find a clear recommendation on possible actions in most clinical decisions in UC treatment, but much more clinical high-quality research is needed.
authors: Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Instituto de Investigación Sanitaria, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Zaragoza, Spain. fgomollon@gmail.com
authors: Fernando
authors: F
authors: Gomollón
authors: Santiago
authors: S
authors: García-López
authors: Beatriz
authors: B
authors: Sicilia
authors: Javier P
authors: JP
authors: Gisbert
authors: Joaquín
authors: J
authors: Hinojosa
mesh_terms: D000465:Algorithms; D003093:Colitis, Ulcerative / Q000628:therapy*; D006801:Humans