title: Hemodynamic assessment of paravalvular aortic regurgitation after TAVI: estimated myocardial supply-demand ratio and cardiovascular mortality.
abstract: A relevant (at least moderate) paravalvular regurgitation (PAR) after transcatheter aortic valve implantation (TAVI) is found in up to 20% of cases and associated with increased mortality. The ratio of the diastolic over the systolic pressure time integral (DPTI:SPTI) has been proposed to reflect an estimate of myocardial oxygen supply versus demand and the propensity for myocardial ischemia. We have now evaluated the potential of this ratio to predict PAR-associated cardiovascular mortality after TAVI, retrospectively analyzing data from 167 consecutive TAVI patients. PAR was graded angiographically, and the myocardial supply-demand ratio was estimated from the planimetric integration of the diastolic and systolic pressure-time area (DPTI and SPTI), respectively. PAR was observed in 113 patients (67%) and angiographically graded as mild in 89 (78.8%), moderate in 21 (18.6%) or moderate to severe in 3 (2.7%) cases. The DPTI:SPTI ratio decreased with increasing Sellers grade of PAR (P < 0.001). A DPTI:SPTI of ≤0.7 predicted cardiovascular mortality (area under the curve = 0.96). Cardiovascular mortality at 30 days and 1 yr was increased in patients with DPTI:SPTI ≤ 0.7 over those with DPTI:SPTI > 0.7 (42 vs. 2% and 63 vs. 3%, respectively; P < 0.001). In conclusion, DPTI:SPTI provides an excellent cutoff value of ≤0.7 for the prediction of PAR-associated mortality.
authors: Department of Cardiology, Essen University Hospital, University Duisburg-Essen, Essen, Germany. polykarpos-christos.patsalis@uk-essen.de
authors: Polykarpos C
authors: PC
authors: Patsalis
authors: Thomas F M
authors: TF
authors: Konorza
authors: Fadi
authors: F
authors: Al-Rashid
authors: Björn
authors: B
authors: Plicht
authors: Heike A
authors: HA
authors: Hildebrandt
authors: Daniel
authors: D
authors: Wendt
authors: Matthias
authors: M
authors: Thielmann
authors: Heinz G
authors: HG
authors: Jakob
authors: Holger
authors: H
authors: Eggebrecht
authors: Gerd
authors: G
authors: Heusch
authors: Raimund
authors: R
authors: Erbel
authors: Philipp
authors: P
authors: Kahlert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D001022:Aortic Valve Insufficiency / Q000401:mortality / Q000503:physiopathology*; D001024:Aortic Valve Stenosis / Q000601:surgery; D001794:Blood Pressure; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000401:mortality*; D006801:Humans; D008297:Male