title: Solid lipid based nanocarriers: an overview.
abstract: In the era of nanoparticulate controlled and site specific drug delivery systems, use of solid lipids to produce first generation lipid nanoparticles, solid lipid nanoparticles (SLN), became a revolutionary approach in the early nineties. The present review is designed to provide an insight into how SLN are finding a niche as promising nanovectors and forms a sound basis to troubleshoot the existing problems associated with traditional systems. Herein, authors had tried to highlight the frontline aspects prominent to SLN. An updated list of lipids, advanced forms of SLN, methods of preparation, characterization parameters, and various routes of administration of SLN are explored in-depth. Stability, toxicity, stealthing, targeting efficiency and other prospectives of SLN are also discussed in detail. The present discussion embodies the potential of SLN, now being looked up by various research groups around the world for their utility in the core areas of pharmaceutical sciences, thereby urging pharmaceutical industries to foster their scale-up.
authors: R. C. Patel Institute of Pharmaceutical Education and Research Shirpur-425405, India. chandrakantpardeshi11@gmail.com
authors: Chandrakantsing
authors: C
authors: Pardeshi
authors: Pravin
authors: P
authors: Rajput
authors: Veena
authors: V
authors: Belgamwar
authors: Avinash
authors: A
authors: Tekade
authors: Ganesh
authors: G
authors: Patil
authors: Kapil
authors: K
authors: Chaudhary
authors: Abhijeet
authors: A
authors: Sonje
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D004355:Drug Stability; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D008055:Lipids