title: Role of methylenetetrahydrofolate reductase A1298C polymorphism in cerebral venous thrombosis.
abstract: The association between the methylenetetrahydrofolate reductase (MTHFR) gene and cerebral venous thrombosis (CVT) remains controversial. This study principally investigated the potential role of the MTHFR A1298C variant and CVT. The genotyping of the A1298C variant of the MTHFR gene was performed in 35 CVT patients and 200 healthy controls. The frequency of A1298C genotype among CVT patients was significantly higher compared with controls (P < 10(-3)), suggesting an association between this polymorphism and CVT. To our knowledge, there are no previous reports assessing the correlation between the MTHFR A1298C variant and CVT. Large study populations would be required to understand the contribution of this marker in the risk of CVT.
authors: Laboratory of Molecular Biology, Department of Hematology, Military Hospital, Tunis, Tunisia. fnajiba@yahoo.fr
authors: Najiba
authors: N
authors: Fekih-Mrissa
authors: Sarra
authors: S
authors: Klai
authors: Meriem
authors: M
authors: Mrad
authors: Jamel
authors: J
authors: Zaouali
authors: Aycha
authors: A
authors: Sayeh
authors: Brahim
authors: B
authors: Nsiri
authors: Nasreddine
authors: N
authors: Gritli
authors: Ridha
authors: R
authors: Mrissa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020767:Intracranial Thrombosis / Q000201:enzymology / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020246:Venous Thrombosis / Q000201:enzymology / Q000235:genetics*; D055815:Young Adult
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)