title: Plasma proteomics for the identification of Alzheimer disease.
abstract: Less-invasive biomarkers for early Alzheimer disease (AD) are urgently needed. The present study aimed to establish a panel of plasma proteins that accurately distinguishes early AD from physiological aging and to compare the findings with previous reports. Fifty-eight healthy controls (CON) and 109 patients with AD dementia were randomly split into a training (40%) and a test (60%) sample. Significant proteins to differentiate between the CON and AD dementia groups were identified in a comprehensive panel of 107 plasma analytes in the training sample; the accuracy in differentiating these 2 groups was explored in the test sample. A set of 5 plasma proteins was identified, which differentiated between the CON group and the AD dementia group with a sensitivity of 89.36% and a specificity of 79.17%. A biological pathway analysis showed that 4 of 5 proteins belonged to a common network with amyloid precursor protein and tau. Apolipoprotein E was the only protein that was both significant in the present report and in a previous proteomic study. The study provides a piece of evidence in support of the feasibility of a blood-based biomarker approach in AD diagnostics; however, further research is required because of issues with replicability.
authors: *Department of Psychiatry and Psychotherapy †Institute for Medical Statistics and Epidemiology, Technische Universität München, Munich, Germany ‡Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK.
authors: Liang-Hao
authors: LH
authors: Guo
authors: Panagiotis
authors: P
authors: Alexopoulos
authors: Stefan
authors: S
authors: Wagenpfeil
authors: Alexander
authors: A
authors: Kurz
authors: Robert
authors: R
authors: Perneczky
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis* / Q000235:genetics; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000235:genetics* / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D040901:Proteomics / Q000379:methods*; D015203:Reproducibility of Results
chemical_list: D001057:Apolipoproteins E; D015415:Biomarkers; D001798:Blood Proteins