title: Vitamin D intake is inadequate in spinal muscular atrophy type I cohort: correlations with bone health.
abstract: Children with type I spinal muscular atrophy commonly demonstrate reduced bone mineral density. Our objectives were to evaluate and assess adequacy of vitamin D intake, serum levels, and association with bone mineral density. Assessments were completed using 3-day food records and dual energy x-ray absorptiometry scans. The spinal muscular atrophy type I cohort included 22 males and 18 females (N = 40), with a mean age of 18.6 months. Data collection occurred from 2001 to 2011. Seventy-five percent of patients had inadequate intake of vitamin D at the initial visit. Using mixed-effects analyses, vitamin D and calcium intakes correlated positively with bone mineral density (r = 0.31 and r = 0.53, respectively). Increased vitamin D and calcium consumption were associated with an increase in bone mineral density (P = .04 and P = .01, respectively). Vitamin D intake correlated positively with serum levels (r = 0.65). Further study is needed to determine optimal intakes of vitamin D and calcium in the spinal muscular atrophy type I population.
authors: 1Intermountain Healthcare, Murray, UT, USA.
authors: Jennifer
authors: J
authors: Aton
authors: Rebecca Hurst
authors: RH
authors: Davis
authors: Kristine C
authors: KC
authors: Jordan
authors: Charles B
authors: CB
authors: Scott
authors: Kathryn J
authors: KJ
authors: Swoboda
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002136:Calcium, Dietary / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015930:Diet Records; D004435:Eating; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D014897:Spinal Muscular Atrophies of Childhood / Q000378:metabolism* / Q000503:physiopathology; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood
chemical_list: D002136:Calcium, Dietary; D014807:Vitamin D
keywords: SMN1; bone mineral density; spinal muscular atrophy type I; vitamin D