title: Redox regulation of tumor suppressor PTEN in cancer and aging (Review).
abstract: Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has been             shown to act as a tumor suppressor whose function includes important roles in             regulating oxidative stress, indicating a potential role in oxidative damage-associated             cancer. Accumulating evidence has revealed that PTEN also acts as a pivotal determinant             of cell fate, regarding senescence and apoptosis, which is mediated by intracellular             reactive oxygen species (ROS) generation. Cells are continuously exposed to ROS,             which represent mutagens and are thought to be a major contributor to cancer and             the aging process. Therefore, cellular ROS sensing and metabolism are firmly regulated             by a variety of proteins involved in the redox mechanism. In this review, PTEN             and the roles of oxidative stress in phosphoinositide-3 kinase/AKT signaling are             summarized with a focus on the links between the pathways and ROS in cancer and             aging.
authors: Department of Environmental Health Science, Nara Women's University,                     Nara 630-8506, Japan.
authors: Yasuko
authors: Y
authors: Kitagishi
authors: Satoru
authors: S
authors: Matsuda
mesh_terms: D017209:Apoptosis; D016922:Cellular Senescence; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051059:PTEN Phosphohydrolase / Q000096:biosynthesis / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human