title: Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia.
abstract: Three new cycloartane triterpenoids, aphagrandinoids A-C (1-3), and a new natural product, aphagrandinoid D (4), together with a known compound, were isolated from the leaves and twigs of Aphanamixis grandifolia. Their structures were elucidated by extensive NMR and MS techniques. Aphagrandinoid A (1), a 29-nor-cycloart triterpenoid, features with a sprio ring system at the side chain, while aphagrandinoid C (3) is a pentnortriterpenoid. Antibacterial activities of these five compounds were also evaluated. Compounds 1 and 5 showed weak antibacterial activities (MIC values: 1.57-3.13μg/mL) against Staphylococcus aureus, MRSA 92(#), and MRSA 98(#).
authors: Faculty of Pharmacy, Yunnan University of TCM, Kunming 650500, Yunnan, People's Republic of China.
authors: Xiao-Ying
authors: XY
authors: Wang
authors: Gui-Hua
authors: GH
authors: Tang
authors: Chun-Mao
authors: CM
authors: Yuan
authors: Yu
authors: Y
authors: Zhang
authors: Tao
authors: T
authors: Zou
authors: Chun
authors: C
authors: Yu
authors: Qing
authors: Q
authors: Zhao
authors: Xiao-Jiang
authors: XJ
authors: Hao
authors: Hong-Ping
authors: HP
authors: He
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D029582:Meliaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D014315:Triterpenes; C583380:aphagrandinoid A; C085352:cycloartane