title: Regular exercise training attenuates pulmonary inflammatory responses to inhaled alumina refinery dust in mice.
abstract: Exposure to alumina dust has been recently associated with impaired lung mechanics and inflammation. We aimed at evaluating if moderate exercise training prevents these outcomes. Twenty-three female BALB/c mice (25-30g) were randomly divided in two main groups: control (C) and exercise (E), which were submitted, or not, to 15min of swimming, 5 days/week during 4 weeks. Then, the animals were exposed for 1h to either saline solution (CS or ES) or to a suspension of 8mg/m(3) of alumina dust (CA or EA). Twenty-four hours later pulmonary mechanics was determined by the end-inflation occlusion method. Left lungs were prepared for histology and right lungs for TGF-β determination. Static elastance increased after alumina dust exposure independently of swimming. In CA group the viscoelastic component of elastance, the viscoelastic/inhomogeneous pressure, the polymorphonuclear amount, the fraction area of alveolar collapse and TGF-β increased. Thus, exercise training may mitigate the pro-inflammatory response to inhaled aluminum refinery dust.
authors: Laboratory of Neuroendocrinology, Federal University of Pará, Belém, Brazil.
authors: Valéria Marques Ferreira
authors: VM
authors: Normando
authors: Flavia
authors: F
authors: Mazzoli-Rocha
authors: Dayse Kelly Molina
authors: DK
authors: Moreira
authors: Bárbara Chaves
authors: BC
authors: Barcellos
authors: Domingos Wanderley
authors: DW
authors: Picanço-Diniz
authors: Walter Araújo
authors: WA
authors: Zin
mesh_terms: D000537:Aluminum Oxide / Q000009:adverse effects*; D000818:Animals; D004391:Dust; D005260:Female; D019570:Inhalation Exposure; D051379:Mice; D008807:Mice, Inbred BALB C; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011014:Pneumonia / Q000139:chemically induced*; D015656:Respiratory Mechanics / Q000187:drug effects
chemical_list: D004391:Dust; D000537:Aluminum Oxide