title: Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.
abstract: Optimization of the ADME properties of a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase resulted in the identification of highly selective compounds with properties suitable for use as in vitro and in vivo tools to probe the effects of Sky inhibition.
authors: Pfizer Global Research & Development, Michigan Laboratories, Ann Arbor, MI 48105, USA. napowell@comcast.net
authors: Noel A
authors: NA
authors: Powell
authors: Jennifer K
authors: JK
authors: Hoffman
authors: Fred L
authors: FL
authors: Ciske
authors: Jeffrey T
authors: JT
authors: Kohrt
authors: Sangita M
authors: SM
authors: Baxi
authors: Yun-Wen
authors: YW
authors: Peng
authors: Min
authors: M
authors: Zhong
authors: Cornel
authors: C
authors: Catana
authors: Jeff
authors: J
authors: Ohren
authors: Lisa A
authors: LA
authors: Perrin
authors: Jeremy J
authors: JJ
authors: Edmunds
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D006801:Humans; D051379:Mice; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D000577:Amides; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; C017205:2,4-diaminopyrimidine; D020794:Receptor Protein-Tyrosine Kinases; C084944:TYRO3 protein, human