title: Detection of breast cancer with a computer-aided detection applied to full-field digital mammography.
abstract: A study was conducted to evaluate the sensitivity of computer-aided detection (CAD) with full-field digital mammography in detection of breast cancer, based on mammographic appearance and histopathology. Retrospectively, CAD sensitivity was assessed in total group of 152 cases for subgroups based on breast density, mammographic presentation, lesion size, and results of histopathological examination. The overall sensitivity of CAD was 91 % (139 of 152 cases). CAD detected 100 % (47/47) of cancers manifested as microcalcifications; 98 % (62/63) of those manifested as non-calcified masses; 100 % (15/15) of those manifested as mixed masses and microcalcifications; 75 % (12/16) of those manifested as architectural distortions, and 69 % (18/26) of those manifested as focal asymmetry. CAD sensitivity was 83 % (10/12) for cancers measuring 1-10 mm, 92 % (37/40) for those measuring 11-20 mm, and 92 % (92/100) for those measuring >20 mm. There was no significant difference in CAD detection efficiency between cancers in dense breasts (88 %; 69/78) and those in non-dense breasts (95 %; 70/74). CAD showed a high sensitivity of 91 % (139/152) for the mammographic appearance of cancer and 100 % sensitivity for identifying cancers manifested as microcalcifications. Sensitivity was not influenced by breast density or lesion size. CAD should be effective for helping radiologists detect breast cancer at an earlier stage.
authors: Department of Radiology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo Tokyo 1138602, Japan. rywakana@nms.ac.jp
authors: Ryusuke
authors: R
authors: Murakami
authors: Shinichiro
authors: S
authors: Kumita
authors: Hitomi
authors: H
authors: Tani
authors: Tamiko
authors: T
authors: Yoshida
authors: Kenichi
authors: K
authors: Sugizaki
authors: Tomoyuki
authors: T
authors: Kuwako
authors: Tomonari
authors: T
authors: Kiriyama
authors: Kenta
authors: K
authors: Hakozaki
authors: Emi
authors: E
authors: Okazaki
authors: Keiko
authors: K
authors: Yanagihara
authors: Shinya
authors: S
authors: Iida
authors: Shunsuke
authors: S
authors: Haga
authors: Shinichi
authors: S
authors: Tsuchiya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity