title: Urinary bisphenol a concentration and thyroid function in Chinese adults.
abstract: BACKGROUND
  Bisphenol A (BPA) is an endocrine disruptor that in animal studies can bind to the thyroid hormone receptor and affect thyroid function. Relevant epidemiologic studies are limited and results are inconsistent. We explored the relationship between urinary BPA and thyroid function in a Chinese population.
  
  
  METHODS
  The study population included 3394 subjects age 40 years or older who were enrolled in a population-based study from Songnan Community, Baoshan District, Shanghai, China, from June through August 2009. We analyzed the association between urinary BPA and thyroid function using multivariate linear regression. Participants were further divided according to thyroid function status, and logistic regression was applied to determine the relationship between urinary BPA and thyroid function.
  
  
  RESULTS
  Each one-quartile increase in BPA was related to an increase of 0.068 pmol/l (95% confidence interval = 0.065- 0.071) in free triiodothyronine and a 0.084 μIU/ml decline (-0.099 to -0.069) in thyroid-stimulating hormone (TSH) in men. For women, there was a 0.10 pmol/l (0.09 to 0.11) increase in free triiodothyronine and a 0.13 μIU/ml decline (-0.14 to -0.11) in TSH. High urinary BPA level was associated with increased thyroid function (adjusted odds ratio= 1.71 [1.26 to 2.32]).
  
  
  CONCLUSIONS
  Our results support previous reports of associations between BPA exposure and altered thyroid hormones in animal models and epidemiologic studies. Because our study is cross-sectional, no causal relationships can be established.
authors: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China.
authors: Tiange
authors: T
authors: Wang
authors: Jieli
authors: J
authors: Lu
authors: Min
authors: M
authors: Xu
authors: Yu
authors: Y
authors: Xu
authors: Mian
authors: M
authors: Li
authors: Yu
authors: Y
authors: Liu
authors: Xiaoguang
authors: X
authors: Tian
authors: Yuhong
authors: Y
authors: Chen
authors: Meng
authors: M
authors: Dai
authors: Weiqing
authors: W
authors: Wang
authors: Shenghan
authors: S
authors: Lai
authors: Yufang
authors: Y
authors: Bi
authors: Guang
authors: G
authors: Ning
mesh_terms: D000368:Aged; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000378:metabolism / Q000652:urine*; D002681:China; D004781:Environmental Exposure / Q000706:statistics & numerical data; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects / Q000378:metabolism / Q000652:urine*; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000009:adverse effects / Q000378:metabolism / Q000652:urine*; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D013972:Thyrotropin; D014284:Triiodothyronine; C006780:bisphenol A; D000098826:Bisphenol A Compounds