title: Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells.
abstract: We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER-PM junctions formed near the leading edge of migrating cells (usually within 0.5 μm of polymerized actin and close to focal adhesions) and appeared suddenly without sliding from the interior of the cell. The long distance sliding and dissolution of ER-PM junctions accompanied the tail withdrawal.
authors: Department of Cellular and Molecular Physiology, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
authors: Hayley
authors: H
authors: Dingsdale
authors: Emmanuel
authors: E
authors: Okeke
authors: Muhammad
authors: M
authors: Awais
authors: Lee
authors: L
authors: Haynes
authors: David N
authors: DN
authors: Criddle
authors: Robert
authors: R
authors: Sutton
authors: Alexei V
authors: AV
authors: Tepikin
mesh_terms: D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism* / Q000473:pathology; D002465:Cell Movement; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000473:pathology; D022001:Focal Adhesions / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology