title: Effects of total glucosides of paeony for delaying onset of Sjogren's syndrome: an animal study.
abstract: OBJECTIVE
  To investigate the effectiveness of total glucosides of paeony (TGP) on Sjogren's syndrome (SS) using non-obese diabetic (NOD) mice model.
  
  
  METHODS
  Twenty-seven 8-week-old female NOD mice were assigned into TGP group, hydroxychloroquine (HCQ) group and normal saline (NS) group, receiving corresponding drugs respectively and sacrificed at 24-week-old. Saliva flow rate (SFR), ration of regulatory T cells, level of anti-SSA/SSB, histological changes in submandibular glands (SMG) and microarray analysis were assessed. The data were analyzed using SPSS.
  
  
  RESULTS
  Compared to NS group, in TGP group, SFR, SMG index and the ration of regulatory T cells were significantly higher, while anti-SSA/SSB and lymphocytic foci were significantly lower. HCQ group demonstrated similar results except SMG index. Altered gene expression was found in 10.71% of TGP and 13.09% of HCQ of the profile.
  
  
  CONCLUSIONS
  TGP demonstrated a similar effectiveness as HCQ in delaying the onset of SS-like disease in NOD mice.
authors: Department of Oral Medicine and Traditional Chinese Medicine, Peking University School and Hospital of Stomatology, Beijing, China.
authors: Chun Lei
authors: CL
authors: Li
authors: Jing
authors: J
authors: He
authors: Zhan Guo
authors: ZG
authors: Li
authors: Li Wu
authors: LW
authors: Zheng
authors: Hong
authors: H
authors: Hua
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000032:analysis; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D020869:Gene Expression Profiling; D005960:Glucosides / Q000627:therapeutic use*; D006886:Hydroxychloroquine / Q000627:therapeutic use; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D051379:Mice; D016688:Mice, Inbred NOD; D046228:Microarray Analysis; D029596:Paeonia / Q000737:chemistry*; D008517:Phytotherapy / Q000379:methods*; D012261:Ribonucleoproteins / Q000032:analysis; D012463:Saliva / Q000187:drug effects / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects; D012859:Sjogren's Syndrome / Q000517:prevention & control*; D013363:Submandibular Gland / Q000187:drug effects / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000473:pathology; D000097585:SS-B Antigen; D000099207:SS-A Antigen
chemical_list: D001324:Autoantigens; D004791:Enzyme Inhibitors; D005960:Glucosides; D006886:Hydroxychloroquine; D012261:Ribonucleoproteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen
keywords: Animal model; Sialoadenitis; Sjogren's syndrome; Total glucosides of paeony