title: Tumor-infiltrating B cells come into vogue.
abstract: Lymphocyte infiltration into solid tumors has been recognized as a main determinator of positive prognosis. For the most part this is attributed to cytotoxic T cells capable of directly destroying malignant cells. However, when considering the complex composition of the human immune system, recent findings of Nielsen et al on a potentially central role of tumor-infiltrating B cells is not really surprising. In this commentary article, I want to highlight the enormous potential impact of this observation for basic and translational research, prognostic procedures and ultimately for the development of future therapeutic concepts.
authors: Division of Molecular Oncology and Immunotherapy, Department of General Surgery, University of Rostock, D-18057 Rostock, Germany. michael.linnebacher@med.uni-rostock.de
authors: Michael
authors: M
authors: Linnebacher
mesh_terms: D018951:Antigens, CD20 / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D010051:Ovarian Neoplasms / Q000276:immunology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000032:analysis*
chemical_list: D018951:Antigens, CD20; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7
keywords: CD20+ tumor-infiltrating lymphocytes; Functional immunology; Immunotherapy; Prognosis; Tumor-infiltrating B cells