title: Cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation-associated dry eye in children.
abstract: Dry eye disease is a well-known late complication of radiation therapy and is often difficult to treat. We evaluated the usefulness of cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation-associated dry eye in children. Eleven children received cyclosporine 0.05% emulsion twice daily after failure of conventional therapy. After 6 months, dry eye manifestations improved in three children (27.3%). The remaining eight children showed no improvement with cyclosporine 0.05% ophthalmic emulsion. These results suggest that twice-daily cyclosporine 0.05% ophthalmic emulsion has limited use in children with refractory radiation-associated chronic dry eye.
authors: Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee College of Medicine, Memphis, Tennessee 38163, USA. mhoehn@uthsc.edu
authors: Mary Ellen
authors: ME
authors: Hoehn
authors: Steven R
authors: SR
authors: Kelly
authors: Matthew W
authors: MW
authors: Wilson
authors: R Christopher
authors: RC
authors: Walton
mesh_terms: D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage*; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000209:etiology; D004655:Emulsions; D005134:Eye Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D009883:Ophthalmic Solutions; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D004655:Emulsions; D007166:Immunosuppressive Agents; D009883:Ophthalmic Solutions; D016572:Cyclosporine