title: Pd-catalyzed aldehyde to ester conversion: a hydrogen transfer approach.
abstract: Aliphatic and aromatic aldehydes are successfully converted into their corresponding esters using Pd(OAc)(2) and XPhos. This approach utilizes a hydrogen transfer protocol: concomitant reduction of acetone to isopropanol provides an inexpensive and sustainable approach that mitigates the need for other oxidants.
authors: Roy and Diana A. Vagelos Laboratories and Penn/Merck Laboratory for High Throughput Experimentation, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.
authors: Brittany A
authors: BA
authors: Tschaen
authors: Jason R
authors: JR
authors: Schmink
authors: Gary A
authors: GA
authors: Molander
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004952:Esters; D006859:Hydrogen / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D004952:Esters; D010165:Palladium; D006859:Hydrogen