title: Lesion length impacts long term outcomes of drug-eluting stents and bare metal stents differently.
abstract: BACKGROUND
  Long lesions have been associated with adverse outcomes in percutaneous coronary interventions with bare metal stents (BMS). However, the exact impact of lesion length on the short- and long-term outcomes of drug-eluting stent (DES) implantations is not as clear.
  
  
  RESULTS
  This study compared the impact of lesion length on angiographic and clinical outcomes of BMS and DES in a single-center prospective registry. Lesion length was divided into tertiles. The primary endpoints were angiographically defined binary in-stent restenosis (ISR) rate and major adverse cardiac event (MACE). Of the 4,312 de novo lesions in 3,447 consecutive patients in the CAPTAIN registry, 2,791 lesions (of 2,246 patients) received BMS, and the remaining 1,521 lesions (of 1,201 patients) received DES. The mean follow-up duration was 4.5 years. The longer the lesion, the higher the ISR rate (14%, 18%, and 29%, p<0.001) and the lower the MACE-free survivals (p = 0.007) in the BMS group. However, lesion length showed no such correlation with ISR rates (4.7%, 3.3%, and 7.8%, p = 0.67) or MACE-free survivals (p = 0.19) in the DES group.
  
  
  CONCLUSIONS
  In our single-center prospective registry, lesion length defined in tertiles has no impact on the short-term (ISR) or long-term (MACE) outcomes of patients implanted with DES. In contrast, longer lesion correlates with higher ISR and MACE rates in BMS group.
authors: Second Section of Cardiology and Percutaneous Coronary Intervention Center Department of Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan.
authors: Shang-Hung
authors: SH
authors: Chang
authors: Chun-Chi
authors: CC
authors: Chen
authors: Ming-Jer
authors: MJ
authors: Hsieh
authors: Chao-Yung
authors: CY
authors: Wang
authors: Cheng-Hung
authors: CH
authors: Lee
authors: I-Chang
authors: IC
authors: Hsieh
mesh_terms: D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000209:etiology; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008670:Metals / Q000009:adverse effects*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D008670:Metals