title: Primary hyperparathyroidism is associated with subclinical peripheral neural alterations.
abstract: OBJECTIVE
  Some case reports have suggested primary hyperparathyroidism (PHPT) and peripheral polyneuropathy (PPN) are associated; however, there are no reports of studies examining this possible relationship. The aim of this study was to evaluate peripheral nerve conduction in subjects with PHPT.
  
  
  METHODS
  The study involved 17 patients with PHPT. Mean patient age was 60.5 ± 12.9 years, serum calcium concentration was 11.5 ± 1.0 mg/dL, and the serum parathyroid hormone (PTH) level was 315 ± 569 pg/dL. The control group comprised 17 individuals without PHPT. The mean age of controls was 60.8 ± 12.5 years and the serum calcium concentration was 9.8 ± 0.3 mg/dL. Motor and sensory nerve conduction was assessed by electroneurography (ENG).
  
  
  RESULTS
  The following ENG parameters differed significantly between the PHPT and control groups: right (R) sural sensory nerve action potential conduction velocity (52.7 ± 6.3 m/s versus 58.0 ± 8.0 m/s; P = .041); R median compound muscle action potential (CMAP) amplitude (7.4 ± 1.6 mV versus 8.9 ± 1.7 mV; P = .002); R median CMAP latency (4.3 ± 1.2 ms versus 3.6 ± 0.6 ms; P = .032); R tibial CMAP latency (4.2 ± 1.1 ms versus 3.3 ± 0.4 ms; P = .001). The neurological examination was normal in all patients.
  
  
  CONCLUSIONS
  Our data demonstrate an association between PHPT and peripheral neurological alterations, consistent with subclinical sensory-motor PPN.
authors: Divisão de Endocrinologia e Diabetes, Hospital Agamenon Magalhães - SUS, Universidade de Pernambuco, Recife, Brazil. erik_td@hotmail.com
authors: Erik Trovão
authors: ET
authors: Diniz
authors: Francisco
authors: F
authors: Bandeira
authors: Otávio Gomes
authors: OG
authors: Lins
authors: Érica Nogueira Bezerra
authors: ÉN
authors: Cavalcanti
authors: Tiago Matos
authors: TM
authors: de Arruda
authors: Alexandre Medeiros Sampaio
authors: AM
authors: Januário
authors: Kaisa Trovão
authors: KT
authors: Diniz
authors: Thyciara Fontenele
authors: TF
authors: Marques
authors: Hildo
authors: H
authors: Azevedo
mesh_terms: D000200:Action Potentials; D000368:Aged; D002118:Calcium / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008475:Median Nerve / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D009046:Motor Neurons / Q000378:metabolism; D009431:Neural Conduction; D010281:Parathyroid Hormone / Q000097:blood; D017933:Peripheral Nervous System / Q000378:metabolism / Q000503:physiopathology*; D011115:Polyneuropathies / Q000209:etiology* / Q000503:physiopathology; D011984:Sensory Receptor Cells / Q000378:metabolism; D012720:Severity of Illness Index; D013497:Sural Nerve / Q000378:metabolism / Q000503:physiopathology; D013979:Tibial Nerve / Q000378:metabolism / Q000503:physiopathology
chemical_list: C470125:PTH protein, human; D010281:Parathyroid Hormone; D002118:Calcium