title: Upper limit of fasting plasma glucose level defined by oral glucose tolerance test in Japanese subjects.
abstract: OBJECTIVE
  There are conflicting interpretations regarding the normal fasting plasma glucose level in Japanese subjects. We therefore aimed to define the upper limit of fasting plasma glucose level.
  
  
  METHODS
  A total of 962 subjects who had a 75-g oral glucose tolerance test were examined. Subjects were divided into two groups - post-load normal glycemic group (2-h plasma glucose <140 mg/dL) and post-load hyperglycemic group (2-h plasma glucose≥140 mg/dL).
  
  
  RESULTS
  There were 434 subjects with post-load normal glycemia and 528 subjects with post-load hyperglycemia. Receiver operating characteristic curve (ROC) demonstrated that the optimal cut-off value for predicting post-load hyperglycemia was a fasting plasma glucose of 99 mg/dL (area under ROC curve=0.81), which had a sensitivity, specificity, and overall diagnostic accuracy of 68%, 81%, 74%, respectively.
  
  
  CONCLUSIONS
  These data suggest that for predicting post-load hyperglycemia, the optimal cut-off value of fasting plasma glucose was 99 mg/dL in Japanese subjects. Thus, the current cut-off value of fasting plasma glucose of 110 mg/dL in Japan might be lowered.
authors: Department of Medicine, Iwao Hospital, Hita, Japan. iwao@oregano.ocn.ne.jp
authors: Tadashi
authors: T
authors: Iwao
authors: Kenji
authors: K
authors: Sakai
authors: Eiji
authors: E
authors: Ando
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D005215:Fasting / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis; D007564:Japan; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D001786:Blood Glucose