title: Matrix-metalloproteinases and proinflammatory cytokines in children with febrile convulsions and epilepsy--cause or consequence?
abstract: This is the first investigation of MMPs in children with febrile seizures. In a prospective, cross sectional study, serum levels of matrix metalloproteinases (MMP8/9), tissue inhibitor of metalloproteinases (TIMP1/2), of children with FS (n=13), children with febrile infection (FI, n=13) and children with unprovoked generalized seizures (US, n=11) were compared. Neither provoked nor unprovoked seizures in FS and US seem to elevate levels of MMPs or TIMPs, whereas in case of febrile infection blood level of MMP8 was significant elevated. Seizures in general might have no influence on this distinctive inflammatory process or even might have suppressive impact.
authors: Clinical Department of Pediatrics I, Medical University Innsbruck, Austria. edda.haberlandt@uki.at
authors: Edda
authors: E
authors: Haberlandt
authors: Markus
authors: M
authors: Rauchenzauner
authors: Maike
authors: M
authors: Morass
authors: Petra
authors: P
authors: Wondrak
authors: Sabine
authors: S
authors: Scholl-Bürgi
authors: Kevin
authors: K
authors: Rostásy
authors: Daniela
authors: D
authors: Karall
mesh_terms: D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D004827:Epilepsy / Q000097:blood / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D018836:Inflammation Mediators / Q000097:blood* / Q000502:physiology; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000097:blood* / Q000502:physiology*; D011446:Prospective Studies; D012640:Seizures / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D003294:Seizures, Febrile / Q000097:blood* / Q000209:etiology / Q000473:pathology*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000097:blood
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators; C560822:TIMP1 protein, human; C560823:TIMP2 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; D019716:Tissue Inhibitor of Metalloproteinase-2; C488762:MMP8 protein, human; D020784:Matrix Metalloproteinase 8