title: Bioactive abietane and ent-kaurane diterpenoids from Isodon tenuifolius.
abstract: Three new abietane diterpenoids, isoabietenins A-C (1-3), and 13 new ent-kauranoids, tenuifolins A-M (4-16), along with four known compounds (17-20), were isolated from the aerial parts of Isodon tenuifolius. The structures of the new metabolites were established on the basis of detailed spectroscopic analysis. The absolute configurations of 1, 15, and 16 were confirmed by single-crystal X-ray diffraction. Selected compounds were evaluated for their cytotoxicity against a small panel of human tumor cell lines, and some compounds showed inhibitory effects. Furthermore, several isolates exhibited inhibitory activity against nitric oxide production in LPS-activated RAW264.7 macrophages.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
authors: Jian-Hong
authors: JH
authors: Yang
authors: Xue
authors: X
authors: Du
authors: Fei
authors: F
authors: He
authors: Hai-Bo
authors: HB
authors: Zhang
authors: Xiao-Nian
authors: XN
authors: Li
authors: Jia
authors: J
authors: Su
authors: Yan
authors: Y
authors: Li
authors: Jian-Xin
authors: JX
authors: Pu
authors: Han-Dong
authors: HD
authors: Sun
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D008070:Lipopolysaccharides; C580670:isoabietenin A; C580671:isoabietenin B; C580672:isoabietenin C; D009569:Nitric Oxide