title: Asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with β-nitroalkenes catalyzed by chiral bifunctional thioureas.
abstract: The first asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with nitroolefins catalyzed by chiral bifunctional thioureas was reported and 2,3-dihydrofuro[3,2-c]-coumarin adducts have been obtained in moderate yields (53-75%) and good enantioselectivities (64-90% ee).
authors: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
authors: Ren-Qiang
authors: RQ
authors: Mei
authors: Xiao-Ying
authors: XY
authors: Xu
authors: Lin
authors: L
authors: Peng
authors: Fan
authors: F
authors: Wang
authors: Fang
authors: F
authors: Tian
authors: Li-Xin
authors: LX
authors: Wang
mesh_terms: D015110:4-Hydroxycoumarins / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D013890:Thiourea / Q000737:chemistry*
chemical_list: C584173:2,3-dihydrofuro(3,2-c)-coumarin; D015110:4-Hydroxycoumarins; D000475:Alkenes; D003374:Coumarins; D009574:Nitro Compounds; D013890:Thiourea; C068805:4-hydroxycoumarin