title: Giant cellulitis-like Sweet Syndrome, a new variant of neutrophilic dermatosis.
abstract: BACKGROUND
  Neutrophilic dermatoses comprise a wide spectrum of inflammatory diseases with overlapping features characterized histologically by the presence of an aseptic neutrophilic infiltrate in the epidermis, dermis, and/or hypodermis and are often associated with systemic inflammatory and neoplastic disorders.
  
  
  METHODS
  We describe 3 patients with an unusual neutrophilic dermatosis characterized by relapsing episodes of fever, widespread infiltrated plaques with bullous appearance, and variable involvement of the arms, legs, abdomen, and/or trunk. Light microscopy studies showed marked edema of the papillary dermis with an inflammatory infiltrate consisting mainly of mature neutrophils. All 3 patients were morbidly obese, and workup revealed underlying cancer in 2 cases: myeloma and breast carcinoma. Management of the underlying disease resulted in long-term remission of the skin disease.
  
  
  CONCLUSIONS
  The clinicopathologic features in our 3 cases best correspond to a widespread giant cellulitis-like form of Sweet syndrome. Knowledge of this newly observed unusual variant of Sweet syndrome within the broad spectrum of neutrophilic diseases is important for its prompt and proper management.
authors: Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
authors: Andre M
authors: AM
authors: Surovy
authors: Nedzmidin
authors: N
authors: Pelivani
authors: Ivan
authors: I
authors: Hegyi
authors: Urs
authors: U
authors: Buettiker
authors: Helmut
authors: H
authors: Beltraminelli
authors: Luca
authors: L
authors: Borradori
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D002481:Cellulitis / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology / Q000628:therapy; D009767:Obesity, Morbid / Q000503:physiopathology*; D012074:Remission Induction / Q000379:methods; D016463:Sweet Syndrome / Q000209:etiology / Q000473:pathology*