title: Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity.
abstract: A practical protocol has been used for the synthesis of benzimidazoles. The reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. After the synthesis of benzimidazoles, we synthesized ester and hydrazide derivatives under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and 3b, 3c, 5a and 6a showed lipase inhibition at various concentrations.
authors: Department of Chemistry, Faculty of Arts and Sciences, Recep Tayyip Erdogan University , Rize , Turkey .
authors: Emre
authors: E
authors: Menteşe
authors: Hakan
authors: H
authors: Bektaş
authors: Serdar
authors: S
authors: Ülker
authors: Olcay
authors: O
authors: Bekircan
authors: Bahittin
authors: B
authors: Kahveci
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008872:Microwaves; D013055:Spectrophotometry, Infrared
chemical_list: D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D008049:Lipase