title: A new triterpenoid from Teucrium viscidum.
abstract: A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9α-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, β-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 1-4 were evaluated for their inhibitory activities against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1).
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors: Xincai
authors: X
authors: Hao
authors: Jinwen
authors: J
authors: Zhang
authors: Guangxin
authors: G
authors: Xia
authors: Yongbo
authors: Y
authors: Xue
authors: Zengwei
authors: Z
authors: Luo
authors: Yanyan
authors: Y
authors: Si
authors: Guangmin
authors: G
authors: Yao
authors: Yonghui
authors: Y
authors: Zhang
mesh_terms: D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D057809:HEK293 Cells; D006801:Humans; D059625:Liquid-Liquid Extraction; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D031367:Teucrium / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification*
chemical_list: D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; D014315:Triterpenes; D042842:11-beta-Hydroxysteroid Dehydrogenases