title: Unusual concomitant rearrangements of Cyclin D1 and MYC genes in blastoid variant of mantle cell lymphoma: Case report and review of literature.
abstract: We report herein a case of blastoid variant mantle cell lymphoma (MCL) with both aberrant phenotype and unusual genetics. Unexpectedly, lymphoma cells were CD5(-) and CD10(+). Standard karyotype and FISH techniques showed that tumor cells carried two distinct translocations which had not been reported together in a same tumor. The first translocation juxtaposed the immunoglobulin lambda light chain locus with CCND1 locus, leading to Cyclin D1 overexpression. The second translocation revealed MYC rearrangement with a non-immunoglobulin gene partner located on the short arm of chromosome 4. The interpretation of the case on tissue sections alone could have been challenging. Indeed, the lack of CD5 and expression of CD10 associated with MYC rearrangement detected on interphasic nuclei could support the diagnosis of diffuse large B-cell lymphoma or Burkitt lymphoma. This distinction is also especially important as these lymphoma subtypes require specific treatment.
authors: Laboratoire de Pathologie du Pr P. Brousset, Hôpital Purpan, CHU Purpan Place du Dr Baylac, Toulouse 31059, France.
authors: Audrey
authors: A
authors: Delas
authors: Dobbelstein
authors: D
authors: Sophie
authors: Pierre
authors: P
authors: Brousset
authors: Camille
authors: C
authors: Laurent
mesh_terms: D059786:Abnormal Karyotype; D000369:Aged, 80 and over; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D016259:Genes, myc / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1