title: Potential antileishmanial effect of three medicinal plants.
abstract: THE ANTILEISHMANIAL ACTIVITY OF THREE ORGANIC SOLVENT EXTRACTS AND WATER RESIDUE OF THE PLANTS: Acacia nilotica (Mimosaceae) (husk), Ambrosia miratima (Astraceae) (aerial shoot) and Azadarichta indica (Meliaceae) (leaves) were tested in vitro against Leishmania donovani promastigotes. The study revealed that the extracts of A. nilotica and A. miratima have effectious antileishmanial activity at concentrations (IC(50)) less than 8 μg/ml, while the extracts of A. indica lack antileishmanial activity. The chromatographic analysis of the ethyl acetate extract of A. nilotica, the most potent extract, resulted in four TLC fractions. Three of these fractions possessed antileishmanial activity. Phytochemical study of the potent fractions revealed the presence of poly hydroxyl compounds.
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, P.O. Box 1996, Sudan.
authors: A
authors: A
authors: Eltayeb
authors: K
authors: K
authors: Ibrahim
keywords: Acacia nilotica; Ambrosia miratima; Azadarichta indica; antileishmanial activity