title: Association between family history and clinicopathologic characteristics in 1987  breast cancer patients: single institution experience from Turkey.
abstract: OBJECTIVE
  To evaluate the clinicopathologic characteristics and survival of patients with family history of breast/ ovarian cancer (FHBOC).
  
  
  METHODS
  In this study with 1987 breast cancer patients, we analyzed their tumor characteristics and outcomes, as well as the total number, degree and age of affected relatives, and their type of cancer. Results were assessed using Pearson chi-square test, Kaplan-Meier method and Cox regression analysis.
  
  
  RESULTS
  24.1% (n=479) of the patients had FHBOC. Patients with FHBOC were younger (47.7 vs. 49.1 years; p=0.03) and tended to have node-negative breast cancer (45.4 vs. 39.8%; p=0.006). The median overall survival (OS) was shorter in patients with FHBOC with a borderline p-value (p=0.063), compared to patients with no family history. The median OS was shorter in patients who had ≥ 2 relatives with breast cancer (p=0.014), in those having first degree relatives with breast cancer, presenting with metastatic disease (p= 0.020). FHBOC patients with triple negative breast cancer had the highest risk of death (p<0.0001) and recurrence (p<0.0001). Patients who had at least one relative with breast cancer aged ≤ 50 years were also at increased risk of recurrence (p7equals;0.006).
  
  
  CONCLUSIONS
  Our results suggest that patients with FH7horbar;BOC are younger, tend to have small tumor size, node-negative disease and their survival is shorter compared to patients without family history. This is the first study evaluating the clinicopathologic differences of patients with and without FHBOC in Turkish population.
authors: Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
authors: F P
authors: FP
authors: Turkoz
authors: M
authors: M
authors: Solak
authors: S
authors: S
authors: Aksoy
authors: I
authors: I
authors: Petekkaya
authors: O
authors: O
authors: Keskin
authors: N
authors: N
authors: Kertmen
authors: F
authors: F
authors: Sarici
authors: Z
authors: Z
authors: Arik
authors: T
authors: T
authors: Babacan
authors: E
authors: E
authors: Simsek
authors: Y
authors: Y
authors: Ozisik
authors: K
authors: K
authors: Altundag
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D015331:Cohort Studies; D005192:Family Health; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D014421:Turkey