title: Is interleukin-17 involved in the interaction between polycystic ovary syndrome and gingival inflammation?
abstract: BACKGROUND
  Polycystic ovarian syndrome (PCOS) is a hormonal disorder of females of reproductive age that impacts their oral and systemic health. The aim of this study is to evaluate interleukin-17A (IL-17A), IL-17F, IL-17A/F, and IL-17E (IL-25) levels in gingival crevicular fluid (GCF), saliva, and serum of non-obese females with PCOS and with either a clinically healthy periodontium or gingivitis.
  
  
  METHODS
  Thirty-one females with PCOS, 30 females with PCOS and gingivitis, and 12 systemically and periodontally healthy females participated in the study. Clinical periodontal measurements, body mass index, and Ferriman-Gallwey score (FGS) (a measure of hirsutism in females) were recorded. Circulating levels of sex hormones, cortisol, and insulin were also determined. Levels of IL-17 cytokines were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The general linear model multivariate analysis, adjusting for age or plaque index, showed that the two groups with PCOS had higher concentrations of IL-17A, IL-17F, and IL-17A/F in serum and higher levels of IL-17A and IL-17F in GCF and saliva but lower serum IL-17E than systemically healthy females. Levels of IL-17E were lowest in females with PCOS and gingivitis who also had the highest FGS. Serum IL-17A and IL-17F levels correlated positively with FGS and periodontal probing depth (all ρ >0.33; P <0.005). Serum IL-17E showed the reverse relationship and also correlated negatively with IL-17A (ρ >-0.28; P <0.05).
  
  
  CONCLUSIONS
  IL-17 levels are altered in non-obese females with PCOS and may influence gingival inflammation. Additional studies are warranted to clarify the relationship between PCOS and gingivitis.
authors: Department of Periodontology, School of Dentistry, Ege University, İzmir, Turkey.
authors: Özgün
authors: Ö
authors: Özçaka
authors: Nurcan
authors: N
authors: Buduneli
authors: Banu Ozturk
authors: BO
authors: Ceyhan
authors: Aliye
authors: A
authors: Akcali
authors: Victoria
authors: V
authors: Hannah
authors: Christopher
authors: C
authors: Nile
authors: David F
authors: DF
authors: Lappin
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D003774:Dental Plaque Index; D005260:Female; D005883:Gingival Crevicular Fluid / Q000276:immunology; D005891:Gingivitis / Q000097:blood / Q000276:immunology*; D006628:Hirsutism / Q000145:classification; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D020381:Interleukin-17 / Q000032:analysis* / Q000097:blood; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D010519:Periodontium / Q000276:immunology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000276:immunology*; D012463:Saliva / Q000276:immunology; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; C486701:IL25 protein, human; D007328:Insulin; D020381:Interleukin-17; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate; D019326:17-alpha-Hydroxyprogesterone; D006854:Hydrocortisone