title: Fabrication and characterization of gold-nanoparticles/chitosan film: a scaffold for L929-fibroblasts.
abstract: The objective of the present study was to fabricate a gold nanoparticle crosslinked chitosan (Ch/AuNPs) composite film simple and to evaluate its use as a carrier matrix for L929- fibroblasts. L929- fibroblasts were seeded either onto Ch or Ch/AuNPs scaffolds. The Ch/AuNPs scaffold exhibited a higher cell proliferation and growth rate. The cytotoxicity test determined trypan blue staining indicated that Ch scaffolds devoid of AuNPs expressed almost no toxicity while the Ch/AuNPs composite scaffolds expressed a very limited toxicity only at higher doses. The Ch/AuNPs scaffold promotes cell attachment, growth and proliferation with almost no cytotoxicity.
authors: Faculty of Life Sciences , Department of Biology, Kırıkkale University , Kırıkkale Turkey.
authors: Mustafa
authors: M
authors: Türk
authors: Uğur
authors: U
authors: Tamer
authors: Erol
authors: E
authors: Alver
authors: Hakan
authors: H
authors: Çiftçi
authors: Ayşegül Ü
authors: AÜ
authors: Metin
authors: Siyami
authors: S
authors: Karahan
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D006046:Gold; D048271:Chitosan