title: One stop screening for multiple cancers: the experience of an integrated cancer prevention center.
abstract: BACKGROUND
  Cancer is a leading cause of mortality worldwide. Screening is a key strategy for reducing cancer morbidity and mortality.
  
  
  METHODS
  We aimed to describe the experience of an integrated cancer prevention center in screening an asymptomatic population for the presence of neoplasia. One-thousand consecutive asymptomatic, apparently healthy adults, aged 20-80 years, were screened for early detection of 11 common cancers that account for 70-80% of cancer mortality.
  
  
  RESULTS
  Malignant and benign lesions were found in 2.4% and 7.1% of the screenees, respectively. The most common malignant lesions were in the gastrointestinal tract and breast followed by gynecological and skin. The compliance rate for the different screening procedures was considerably higher than the actual screening rate in the general Israeli population - 78% compared to 60% for mammography (p<0.001) and 39% compared to 16% for colonoscopy (p<0.001). Advanced age, family history of cancer and certain lifestyle parameters were associated with increased risk. Moreover, polymorphisms in the APC and CD24 genes indicated high cancer risk. When two of the polymorphisms existed in an individual, the risk for a neoplastic lesion was extremely high (OR 2.3 [95% CI 0.94-5.9]).
  
  
  CONCLUSIONS
  One stop shop screening for 11 common cancers in the setting of a multidisciplinary outpatient clinic is feasible and can detect cancer at an early stage.
authors: The Integrated Cancer Prevention Center, Tel-Aviv Sourasky Medical Center/Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors: Tal
authors: T
authors: Sella
authors: Ben
authors: B
authors: Boursi
authors: Amira
authors: A
authors: Gat-Charlap
authors: Ilan
authors: I
authors: Aroch
authors: Eliezer
authors: E
authors: Liberman
authors: Menachem
authors: M
authors: Moshkowitz
authors: Ehud
authors: E
authors: Miller
authors: Eyal
authors: E
authors: Gur
authors: Roy
authors: R
authors: Inbar
authors: Arye
authors: A
authors: Blachar
authors: Nicola J
authors: NJ
authors: Mabjeesh
authors: Olivia
authors: O
authors: Rosenfeld
authors: Fanny
authors: F
authors: Sperber
authors: Vadim
authors: V
authors: Reiser
authors: Shlomi
authors: S
authors: Kleinman
authors: Ariel J
authors: AJ
authors: Jaffa
authors: Miki
authors: M
authors: Bloch
authors: Mati
authors: M
authors: Ormianer
authors: Inna
authors: I
authors: Naumov
authors: Diana
authors: D
authors: Kazanov
authors: Sarah
authors: S
authors: Kraus
authors: Lior
authors: L
authors: Galazan
authors: Nadir
authors: N
authors: Arber
mesh_terms: D000046:Academic Medical Centers / Q000379:methods; D000328:Adult; D000367:Age Factors; D000368:Aged; D058070:Asymptomatic Diseases / Q000453:epidemiology*; D051927:CD24 Antigen / Q000235:genetics; D055088:Early Detection of Cancer / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D017491:Genes, APC; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008019:Life Style; D008297:Male; D008403:Mass Screening / Q000379:methods / Q000706:statistics & numerical data; D009369:Neoplasms / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D011110:Polymorphism, Genetic; D011314:Preventive Health Services / Q000379:methods; D012307:Risk Factors
chemical_list: D051927:CD24 Antigen