title: [Musculoskeletal chronic pains and Vitamin D deficiency. Study before after in general practice].
abstract: OBJECTIVE
  The objective of this study was to evaluate the effect of the correction of vitamin D deficiency (defined by a rate≤50 nmol/l) on the pain, fatigue and quality of life.
  
  
  METHODS
  A pragmatic prospective study was conducted in Rhone-Alpes area, in general practices between February 1 and April 30, 2009. All patients aged 18 to 50 years consulting for diffuse musculoskeletal pain and/or chronic unexplained fatigue, with the only abnormality deficient serum vitamin D were enrolled in this study. They might agree to complete questionnaires on quality of life, pain assessment and control their vitamin D levels after treatment.
  
  
  RESULTS
  Forty-nine complete records were analyzed. The deficiency was severe (mean 26 nmol/l). High doses of vitamin were necessary to correct deficiency, between 400,000 to 600,000 units. The correction of vitamin D deficiency resulted in a significant decrease in the level of pain intensity according to verbal rating scale (P=0.034) and the Digital Scale (P<0.001), consumption of analgesics (P=0.002) and discomfort in carrying out activities of daily living following: the shopping, cleaning, walking for more than a kilometer (P<0.001) and dressing (P=0.012).
  
  
  CONCLUSIONS
  The correction has had a positive impact both physical, mental and social activities. Non-specific musculoskeletal pain or unexplained asthenia are common in primary care. Make a dosage of vitamin D and correct deficits is a necessity before performing complex and expensive examinations.
authors: Université médicale Lyon Est, 8, avenue Rockefeller, 69008 Lyon, France. mf.legoaziou@medsyn.fr
authors: Marie-France
authors: MF
authors: Le Goaziou
authors: Edwige
authors: E
authors: Bodier
authors: Gilbert
authors: G
authors: Souweine
authors: Alain
authors: A
authors: Moreau
authors: Corinne
authors: C
authors: Perdrix
authors: Marie
authors: M
authors: Flori
authors: Christian
authors: C
authors: Dupraz
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D005221:Fatigue / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D005260:Female; D005602:France; D058006:General Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D059352:Musculoskeletal Pain / Q000175:diagnosis* / Q000188:drug therapy* / Q000523:psychology; D010147:Pain Measurement / Q000187:drug effects / Q000523:psychology; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology; D012017:Referral and Consultation; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood*; D014808:Vitamin D Deficiency / Q000175:diagnosis* / Q000188:drug therapy* / Q000523:psychology; D055815:Young Adult
chemical_list: D014807:Vitamin D