title: Choline Molecular Imaging with Small-animal PET for Monitoring Tumor Cellular Response to Photodynamic Therapy of Cancer.
abstract: We are developing and evaluating choline molecular imaging with positron emission tomography (PET) for monitoring tumor response to photodynamic therapy (PDT) in animal models. Human prostate cancer (PC-3) was studied in athymic nude mice. A second-generation photosensitizer Pc 4 was used for PDT in tumor-bearing mice. MicroPET images with (11)C-choline were acquired before PDT and 48 h after PDT. Time-activity curves of (11)C-choline uptake were analyzed before and after PDT. For treated tumors, normalized choline uptake decreased significantly 48 h after PDT, compared to the same tumors pre-PDT (p < 0.001). However, for the control tumors, normalized choline uptake increased significantly (p < 0.001). PET imaging with (11)C-choline is sensitive to detect early tumor response to PDT in the animal model of human prostate cancer.
authors: Department of Radiology, Emory University, Atlanta, GA ; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.
authors: Baowei
authors: B
authors: Fei
authors: Hesheng
authors: H
authors: Wang
authors: Chunying
authors: C
authors: Wu
authors: Joseph
authors: J
authors: Meyers
authors: Liang-Yan
authors: LY
authors: Xue
authors: Gregory
authors: G
authors: Maclennan
authors: Mark
authors: M
authors: Schluchter