title: Molecular mechanisms and function prediction of long noncoding RNA.
abstract: The central dogma of gene expression considers RNA as the carrier of genetic information from DNA to protein. However, it has become more and more clear that RNA plays more important roles than simply being the information carrier. Recently, whole genome transcriptomic analyses have identified large numbers of dynamically expressed long noncoding RNAs (lncRNAs), many of which are involved in a variety of biological functions. Even so, the functions and molecular mechanisms of most lncRNAs still remain elusive. Therefore, it is necessary to develop computational methods to predict the function of lncRNAs in order to accelerate the study of lncRNAs. Here, we review the recent progress in the identification of lncRNAs, the molecular functions and mechanisms of lncRNAs, and the computational methods for predicting the function of lncRNAs.
authors: Institute of Biostatistics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 2004333, China.
authors: Handong
authors: H
authors: Ma
authors: Yun
authors: Y
authors: Hao
authors: Xinran
authors: X
authors: Dong
authors: Qingtian
authors: Q
authors: Gong
authors: Jingqi
authors: J
authors: Chen
authors: Jifeng
authors: J
authors: Zhang
authors: Weidong
authors: W
authors: Tian
mesh_terms: D019295:Computational Biology / Q000379:methods; D030561:Databases, Nucleic Acid; D062085:RNA, Long Noncoding / Q000737:chemistry / Q000502:physiology*; D017423:Sequence Analysis, RNA; D059467:Transcriptome
chemical_list: D062085:RNA, Long Noncoding