title: Selective reduction of condensed N-heterocycles using water as a solvent and a hydrogen source.
abstract: The reduction of unprotected indoles and quinolines is described using water as a hydrogen source. The method is based on the application of a RANEY® type Ni-Al alloy in an aqueous medium. During the reaction the Al content of the alloy, used as reductants, reacts with water in situ providing hydrogen and a RANEY® Ni catalyst, thus the alloy serves as a hydrogen generator as well as a hydrogenation catalyst. The simplicity and efficacy of the method are illustrated by the selective reduction of a variety of substituted indoles and quinolines to indolines and tetrahydroquinolines, respectively.
authors: University of Massachusetts Boston, 100 Morrissey Blvd., Boston, MA, USA.
authors: Hyejin
authors: H
authors: Cho
authors: Fanni
authors: F
authors: Török
authors: Béla
authors: B
authors: Török
mesh_terms: D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012997:Solvents / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D012997:Solvents; D014867:Water; D006859:Hydrogen