title: Matrix metalloproteinase-14 is a negative prognostic marker for patients with gastric cancer.
abstract: BACKGROUND
  Matrix metalloproteinase-14 (MMP-14) has been considered to play an important role in invasion and metastasis of human solid tumor.
  
  
  OBJECTIVE
  The present study aimed to investigate the association of MMP-14 with overall survival in human gastric cancer.
  
  
  METHODS
  Gastric cancer and adjacent normal specimens were collected from 205 patients who had not received neoadjuvant chemotherapy. MMP-14 expression was investigated by immunohistochemistry assay and staining evaluation results were analyzed statistically in relation to overall survival of patients.
  
  
  RESULTS
  MMP-14 expression proved to be increased in gastric cancer compared with that in normal tissues. It was also proved that MMP-14 expression was associated with tumor invasion, metastasis, and TNM stage while no correlations were detected between MMP-14 expression and age, sex, differentiation status, or Lauren's classification. Moreover, patients with gastric cancer of MMP-14-positive expression tend to have worse overall survival compared with those with MMP-14 negative expression.
  
  
  CONCLUSIONS
  The present study confirmed the over-expression of MMP-14 in human gastric cancer and its association with tumor progression. It also provided the first evidence that MMP-14 expression in gastric cancer was an independent negative prognostic factor of patients.
authors: Department of Gastrointestinal Surgery, State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.
authors: Liang
authors: L
authors: He
authors: Dake
authors: D
authors: Chu
authors: Xia
authors: X
authors: Li
authors: Jianyong
authors: J
authors: Zheng
authors: Shanhong
authors: S
authors: Liu
authors: Jipeng
authors: J
authors: Li
authors: Qingchuan
authors: Q
authors: Zhao
authors: Gang
authors: G
authors: Ji
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002681:China / Q000453:epidemiology; D005260:Female; D005757:Gastritis, Atrophic / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D008297:Male; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality* / Q000473:pathology
chemical_list: D015415:Biomarkers; C507086:MMP14 protein, human; D053511:Matrix Metalloproteinase 14