title: Rapid total synthesis of (±)trigonoliimine A via a Strecker/Houben-Hoesch sequence.
abstract: A novel synthetic route to the hexacyclic system of trigonoliimine A was accomplished in four steps from N-phthaloyl 6-OMe-tryptamine. Key reactions include a three-component Strecker-type reaction to fashion the two C-N bonds in the D ring and a subsequent Houben-Hoesch type cyclization to deliver the characteristic seven-membered C ring.
authors: The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, 202 Sha-Chong Road, Guiyang 550002, PR China.
authors: Bing
authors: B
authors: Zhao
authors: Xiao-Yan
authors: XY
authors: Hao
authors: Jian-Xin
authors: JX
authors: Zhang
authors: Sheng
authors: S
authors: Liu
authors: Xiao-Jiang
authors: XJ
authors: Hao
mesh_terms: D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D026121:Indole Alkaloids; C551376:trigonoliimine A