title: Salmonella SL7207 application is the most effective DNA vaccine delivery method for successful tumor eradication in a murine model for neuroblastoma.
abstract: Attenuated Salmonella is an approved oral life vaccine that is currently entering pre-clinical cancer vaccination studies as a promising DNA carrier. In a syngeneic mouse model for neuroblastoma, oral gavage of Salmonella typhimurium (SL7207) carrying recent generated survivin DNA vaccines induced a stronger cellular anti-NB immune response than gene gun application or injection of lentivirally transduced bone marrow-derived DCs. The level of Salmonella-associated side effects was not significant as indicated by unaffected survivin-mediated hematopoiesis and wound healing. We believe that our findings provide an important baseline to translate Salmonella-based DNA vaccination into a clinical application for neuroblastoma.
authors: Laboratory of Pediatric Immunotherapy, Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von Guericke University of Magdeburg, Germany.
authors: Elisa
authors: E
authors: Berger
authors: Rocio
authors: R
authors: Soldati
authors: Nicole
authors: N
authors: Huebener
authors: Oliver
authors: O
authors: Hohn
authors: Alexander
authors: A
authors: Stermann
authors: Tahir
authors: T
authors: Durmus
authors: Stephan
authors: S
authors: Lobitz
authors: Ana C
authors: AC
authors: Zenclussen
authors: Holger
authors: H
authors: Christiansen
authors: Holger N
authors: HN
authors: Lode
authors: Stefan
authors: S
authors: Fest
mesh_terms: D000818:Animals; D019470:Biolistics; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D009447:Neuroblastoma / Q000473:pathology / Q000628:therapy*; D010957:Plasmids; D012475:Salmonella / Q000276:immunology*; D019444:Vaccines, DNA / Q000008:administration & dosage*
chemical_list: D019444:Vaccines, DNA