title: Infant's bilobar thyroid agenesis and mother's I-131 accidental administration.
abstract: Bilobar thyroid agenesis is one of rare diseases. Genetic and environmental factors may associate with bilobar thyroid agenesis. But the mechanism is still not completely understood. It had been showed that I-131 administration during pregnancy may induce thyroid dysfunction in newborn. Here we reported a case of female hospital staff who received I-131 accidently during (10-12th gestational weeks) and after her pregnancy. The absorbed dose to fetus was higher than 30mGy. At birth, the infant was found to have no thyroid. It was speculated that the fetal thyroid agenesis may be related with mother' I-131 administration during pregnancy. In addition, this case report also indicated that the radiation dose should be minimized to any developing embryo.
authors: Institute of Radiation Medicine, Fudan University, Xietu road, 200032 Shanghai, China. chx_win@hotmail.com
authors: Shuquan
authors: S
authors: Zhao
authors: Xiao
authors: X
authors: Chen
authors: Guoying
authors: G
authors: Zhu
mesh_terms: D000016:Abnormalities, Radiation-Induced / Q000175:diagnosis; D000062:Accidents, Occupational; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects*; D018811:Maternal Exposure / Q000009:adverse effects*; D008505:Medical Staff, Hospital; D009034:Mother-Child Relations; D009035:Mothers; D009684:Nuclear Medicine Department, Hospital; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000209:etiology; D050033:Thyroid Dysgenesis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D007457:Iodine Radioisotopes; D013974:Thyroxine