title: Materials based tumor immunotherapy vaccines.
abstract: Immunotherapy is a promising approach for treating cancer. However, there are limitations inherent to current approaches which may be addressed by integrating them with biomaterial-based strategies. Material platforms have been fabricated to interact with immune cells through spatially controlled and temporally controlled delivery of immune modulators and to promote immune cell crosstalk. Particle vaccines have been developed to specifically target and deliver agents to organs, cells and subcellular compartments. These strategies have been shown to generate antigen-specific CTL responses and, in some cases, tumor regression. Therefore, collaboration between immunology and materials engineering is likely to result in the creation of strong vaccines to combat cancer in the future.
authors: School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, 319 Pierce Hall, Cambridge, MA 02138, USA.
authors: Weiwei Aileen
authors: WA
authors: Li
authors: David J
authors: DJ
authors: Mooney
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000639:trends; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology
chemical_list: D019496:Cancer Vaccines