title: Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins.
abstract: Six sulfonamides derived from indanes and tetralines were synthesized. The human carbonic anhydrase isozymes hCA I and hCA II inhibition effects of the synthesized sulfonamides were determined. From these compounds, while N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methane sulfonamide showed the most potent inhibitory effect against hCA I (Ki=46 ± 5.4 µM, r(2) =0.978), N-(1,2,3,4-tetrahydronaphthalene-2-yl)methanesulfonamide was found to have the best inhibitory effect against hCA II (Ki=94 ± 7.6 µM, r(2) =0.982).
authors: Faculty of Science, Department of Chemistry, Atatürk University , Erzurum , Turkey .
authors: Yusuf
authors: Y
authors: Akbaba
authors: Akın
authors: A
authors: Akıncıoğlu
authors: Hülya
authors: H
authors: Göçer
authors: Süleyman
authors: S
authors: Göksu
authors: Ilhami
authors: I
authors: Gülçin
authors: Claudiu T
authors: CT
authors: Supuran
mesh_terms: D000588:Amines / Q000737:chemistry*; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000588:Amines; D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides