title: Allergen-specific immunotherapy: update on immunological mechanisms.
abstract: Immunotherapy selectively modulates the allergen-specific immune response. It involves the gradual administration of increasing amounts of allergen for the purpose of inducing protective immunological changes and it is the only curative approach for specific type I allergy.
  
  
  OBJECTIVE
  Description of the allergic inflammation.- Comprehension of the early cellular changes after specific immunotherapy has been initiated. Exposure of the mechanisms involved in tolerance induction by regulatory T cells (Treg) with the inhibition of the Th2 responses. Comprehension of IL-10 and transforming growth factor (TGF- ) roles. Explanation of specific IgE, IgG and IgA changes. Description of the suppression of inflammatory responses during immunotherapy.
authors: Sección de Alergia y Inmunología Clínica, Hospital Sant Joan de Déu, Esplugues, Universitat de Barcelona, Spain.
authors: M
authors: M
authors: Alvaro
authors: J
authors: J
authors: Sancha
authors: H
authors: H
authors: Larramona
authors: J M
authors: JM
authors: Lucas
authors: M
authors: M
authors: Mesa
authors: A I
authors: AI
authors: Tabar
authors: A
authors: A
authors: Martinez-Cañavate
mesh_terms: D000485:Allergens / Q000276:immunology / Q000627:therapeutic use*; D003888:Desensitization, Immunologic / Q000379:methods; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000628:therapy*; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007249:Inflammation / Q000276:immunology / Q000628:therapy
chemical_list: D000485:Allergens
keywords: Allergen-specific immunotherapy; Immunological mechanisms