title: Blood pressure decreases more after high-carbohydrate meals than after high-protein meals in overweight adults with elevated blood pressure, but there is no difference after 4 weeks of consuming a carbohydrate-rich or protein-rich diet.
abstract: The replacement of dietary carbohydrates with proteins can lower blood pressure (BP), but the mechanisms remain unclear. This randomized, double-blind, parallel-group study aimed to compare 12-h postprandial sympathetic and hemodynamic responses after high-protein (HP) meals and high-carbohydrate (HC) meals. Fifty-two men and women with untreated elevated BP were tested on d 1 and after 4 wk of supplementation [3 × 20 g protein (HP) or maltodextrin (HC) per day]. No between-group differences were found in postprandial plasma norepinephrine on d 1 and at wk 4. On d 1, postprandial mean arterial pressure (MAP) decreased more in the HC group than in the HP group (P = 0.002). This difference was not present at 4 wk, because the postprandial decline in MAP tended to become larger in the HP group after 4 wk of supplementation (P = 0.07). On both test days, postprandial total peripheral resistance tended to decrease more in the HC group (P < 0.08). After 4 wk of supplementation, cardiac output tended to increase more in the HC group (P = 0.08). In conclusion, ingestion of an HP diet induced a smaller decrease in BP on d 1 than did ingestion of an HC diet. This difference disappeared after 4 wk due to a more pronounced decrease in BP in the HP group after 4 wk than on d 1. These findings cannot explain the BP-lowering effect ascribed to dietary proteins.
authors: Top Institute Food and Nutrition, Wageningen, The Netherlands. kfm.teunissen@maastrichtuniversity.nl
authors: Karianna F M
authors: KF
authors: Teunissen-Beekman
authors: Janneke
authors: J
authors: Dopheide
authors: Johanna M
authors: JM
authors: Geleijnse
authors: Stephan J L
authors: SJ
authors: Bakker
authors: Elizabeth J
authors: EJ
authors: Brink
authors: Peter W
authors: PW
authors: de Leeuw
authors: Jan
authors: J
authors: Serroyen
authors: Marleen A
authors: MA
authors: van Baak
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D002302:Cardiac Output; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D050177:Overweight / Q000150:complications / Q000503:physiopathology*; D011134:Polysaccharides / Q000008:administration & dosage; D019518:Postprandial Period / Q000502:physiology*; D013997:Time Factors; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D011134:Polysaccharides; C008315:maltodextrin; D009638:Norepinephrine