title: Self-regressing S100-negative CD1a-positive cutaneous histiocytosis.
abstract: In the skin, the antigen-presenting cells are mainly represented by Langerhans cells, indeterminate cells, and interstitial dendritic cells, which show distinctive immunophenotype and/or ultrastructure. We report a case of a cutaneous-limited self-regressing histiocytosis with a peculiar immunohistochemical profile (CD1a-positive and S100 protein-negative) that is not observed in any of the known cutaneous antigen-presenting cell or nowadays recognized neoplasm. This lesion is probably related to indeterminate dendritic cell tumors, but very few cases with such immunoprofile have been reported up-to-date, and their exact nosologic position and outcome remain to be clarified.
authors: Department of Pathology, Hospital Universitario de Fuenlabrada, Madrid, Spain. jtardio.hflr@salud.madrid.org
authors: Juan C
authors: JC
authors: Tardío
authors: Marta
authors: M
authors: Aguado
authors: Jesús
authors: J
authors: Borbujo
mesh_terms: D018949:Antigens, CD1 / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D049109:Cell Proliferation; D005260:Female; D015614:Histiocytosis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008875:Middle Aged; D012075:Remission, Spontaneous; D009418:S100 Proteins / Q000032:analysis*; D012871:Skin Diseases / Q000276:immunology* / Q000473:pathology
chemical_list: D018949:Antigens, CD1; D015415:Biomarkers; C419393:CD1a antigen; D009418:S100 Proteins