title: Differential effects of chronic social stress and fluoxetine on meal patterns in mice.
abstract: Both chronic stress and antidepressant medications have been associated with changes in body weight. In the current study, we investigate mechanisms by which stress and antidepressants interact to affect meal patterns. A group of mice was subjected to the chronic social defeat stress model of major depression followed by fluoxetine treatment and was subsequently analyzed for food intake using metabolic cages. We report that chronic social defeat stress increases food intake by specifically increasing meal size, an effect that is reversed by fluoxetine treatment. In an attempt to gain mechanistic insight into changes in meal patterning induced by stress and fluoxetine, fasting serum samples were collected every 4h over a 24-h period, and acyl-ghrelin, leptin, and corticosterone levels were measured. Chronic stress induces a peak in acyl-ghrelin levels just prior to the onset of the dark phase, which is shifted in mice treated with fluoxetine. Taken together, these results indicate that stress increases food intake by decreasing satiation, and that fluoxetine can reverse stress-induced changes in meal patterns.
authors: Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA. jaswinder.kumar@utsouthwestern.edu
authors: Jaswinder
authors: J
authors: Kumar
authors: Jen-Chieh
authors: JC
authors: Chuang
authors: Elisa S
authors: ES
authors: Na
authors: Anna
authors: A
authors: Kuperman
authors: Andrea G
authors: AG
authors: Gillman
authors: Shibani
authors: S
authors: Mukherjee
authors: Jeffrey M
authors: JM
authors: Zigman
authors: Colleen A
authors: CA
authors: McClung
authors: Michael
authors: M
authors: Lutter
mesh_terms: D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D002908:Chronic Disease; D003345:Corticosterone / Q000097:blood; D004435:Eating / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects; D005473:Fluoxetine / Q000494:pharmacology / Q000627:therapeutic use*; D054439:Ghrelin / Q000097:blood; D020738:Leptin / Q000097:blood; D062407:Meals / Q000187:drug effects; D051379:Mice; D009765:Obesity / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D012527:Satiation / Q000187:drug effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D012931:Social Environment; D013315:Stress, Psychological / Q000150:complications*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003345:Corticosterone; D005473:Fluoxetine; D054439:Ghrelin; D020738:Leptin; D017367:Selective Serotonin Reuptake Inhibitors