title: Role of medial prefrontal cortex Narp in the extinction of morphine conditioned place preference.
abstract: Narp knockout (KO) mice demonstrate an impaired extinction of morphine conditioned place preference (CPP). Because the medial prefrontal cortex (mPFC) has been implicated in extinction learning, we tested whether Narp cells in this region play a role in the extinction of morphine CPP. We found that intracranial injections of adenoassociated virus (AAV) expressing wild-type (WT) Narp into the mPFC of Narp KO mice rescued the extinction and the injection of AAV expressing a dominant negative form of Narp (NarpN) into the mPFC of WT mice impaired the extinction of morphine CPP. These findings suggest that Narp in the mPFC mediates the extinction of morphine CPP.
authors: Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.
authors: Ashley M
authors: AM
authors: Blouin
authors: Sungho
authors: S
authors: Han
authors: Anne M
authors: AM
authors: Pearce
authors: Kailun
authors: K
authors: Cheng
authors: Jongah J
authors: JJ
authors: Lee
authors: Alexander W
authors: AW
authors: Johnson
authors: Chuansong
authors: C
authors: Wang
authors: Matthew J
authors: MJ
authors: During
authors: Peter C
authors: PC
authors: Holland
authors: Yavin
authors: Y
authors: Shaham
authors: Jay M
authors: JM
authors: Baraban
authors: Irving M
authors: IM
authors: Reti
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002097:C-Reactive Protein / Q000172:deficiency / Q000378:metabolism*; D003216:Conditioning, Operant / Q000502:physiology*; D000229:Dependovirus / Q000235:genetics; D005108:Extinction, Psychological / Q000502:physiology*; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008845:Microinjections; D009020:Morphine / Q000008:administration & dosage*; D009294:Narcotics / Q000008:administration & dosage*; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D001426:Bacterial Proteins; D002097:C-Reactive Protein; D008164:Luminescent Proteins; D009020:Morphine; D009294:Narcotics; D009419:Nerve Tissue Proteins; D000099153:Pentraxins; C054562:yellow fluorescent protein, Bacteria