title: Fox-Fordyce-like disease following laser hair removal appearing on all treated areas.
abstract: Fox-Fordyce disease is an uncommon inflammatory disease of the apocrine sweat glands. Two recent reports indicated laser hair removal as a novel cause of axillary Fox-Fordyce disease. We report the first case of Fox-Fordyce disease developing in women after completing treatment with a depilatory hair laser appearing in the axillae, umbilicus, and pubis. We describe a case of Fox-Fordyce disease that developed in a 27-year-old woman 3 months after she had completed two LightSheer Diode laser treatments of her axilla, periumbilical region, and bikini area. Clinical and histopathological changes are as well detailed. Laser therapy induces damage to follicular infundibulum, resulting in altered maturation of keratinocytes which led to keratin plugging causing the common pathologic features in Fox-Fordyce disease. Differences in the physiologic features of the anatomic sites, in the susceptibility to laser-induced injury among these areas, or additional factors may contribute to Fox-Fordyce disease.
authors: Dermatology Department, Hôtel-Dieu de France Hospital, Beirut, Lebanon.
authors: Josiane
authors: J
authors: Helou
authors: Ismaël
authors: I
authors: Maatouk
authors: Roy
authors: R
authors: Moutran
authors: Grace
authors: G
authors: Obeid
mesh_terms: D000328:Adult; D005260:Female; D005588:Fox-Fordyce Disease / Q000209:etiology* / Q000473:pathology; D006204:Hair Removal / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D054023:Lasers, Semiconductor / Q000009:adverse effects*