title: Acute liver toxicity due to methylprednisolone: consider this diagnosis in the context of autoimmunity.
abstract: The occurrence of corticosteroid-induced hepatitis is a rare event that has been recently described in the literature. We report the case of an acute cytolytic hepatitis in a patient treated with methylprednisolone for multiple sclerosis associated with an autoimmune thyroid dysfunction. After ruling out other etiologies, we concluded that the acute liver injury was due to steroids, and we analyzed the specific circumstances in the literature where methylprednisolone may have been responsible for acute hepatitis.
authors: Service d'hépato-gastroentérologie, CHU de Limoges, 2, avenue Martin-Luther-King, 87042 Limoges, France. pcarrier@hotmail.fr
authors: P
authors: P
authors: Carrier
authors: B
authors: B
authors: Godet
authors: S
authors: S
authors: Crepin
authors: L
authors: L
authors: Magy
authors: M
authors: M
authors: Debette-Gratien
authors: B
authors: B
authors: Pillegand
authors: J
authors: J
authors: Jacques
authors: D
authors: D
authors: Sautereau
authors: E
authors: E
authors: Vidal
authors: F
authors: F
authors: Labrousse
authors: G
authors: G
authors: Gondran
authors: V
authors: V
authors: Loustaud-Ratti
mesh_terms: D000328:Adult; D015551:Autoimmunity; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology* / Q000276:immunology; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008775:Methylprednisolone / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000188:drug therapy
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone