title: Lamotrigine in binge-eating disorder associated with bipolar II depression and treatment-resistant type 2 diabetes mellitus: a case report.
abstract: BACKGROUND
  Lamotrigine (LMG) is an anticonvulsant currently registered for the treatment of bipolar disorder (BP) depression. We report the case of a 61-year-old woman with comorbid binge-eating disorder (BED), BP depression, and treatment-resistant type 2 diabetes mellitus (T2DM), in which LMG showed significant efficacy against BED and BP depression and resulted in a drastic decrease in plasma glucose levels.
  
  
  METHODS
  The patient had had untreated BP depression, BED, and T2DM for more than 30 years. We prescribed LMG at 25 mg/d for BP depression and titrated it up to 50 mg/d over 4 weeks, then maintained this dose for the next 16 weeks. At follow-up after the first 4-week period, she reported a significant decrease in compulsive eating impulses and depressive mood, and her positive reports were consistent in the following months. Hemoglobin A1c levels at National Glycohemoglobin Standardization Program decreased drastically from 9.6% to 7.1% over the 20 weeks after initiating treatment.
  
  
  CONCLUSIONS
  This case suggests that LMG might be beneficial for BED with concomitant BP depression, and potentially for treatment-resistant T2DM, if this refractoriness is identified to result from comorbidity of BED and BP.
authors: Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan. sangrecaliente54@gmail.com
authors: Tetsuya
authors: T
authors: Yamamoto
authors: Nobuhisa
authors: N
authors: Kanahara
authors: Aizan
authors: A
authors: Hirai
authors: Hiroyuki
authors: H
authors: Watanabe
authors: Masaomi
authors: M
authors: Iyo
mesh_terms: D018692:Antimanic Agents / Q000494:pharmacology / Q000627:therapeutic use; D056912:Binge-Eating Disorder / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D001714:Bipolar Disorder / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008875:Middle Aged; D014227:Triazines / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D018692:Antimanic Agents; D001786:Blood Glucose; D014227:Triazines; D000077213:Lamotrigine