title: Rethinking 5-HT1A receptors: emerging modes of inhibitory feedback of relevance to emotion-related behavior.
abstract: The complexities of the involvement of the serotonin transmitter system in numerous biological processes and psychiatric disorders is, to a substantial degree, attributable to the large number of serotonin receptor families and subtypes that have been identified and characterized for over four decades. Of these, the 5-HT(1A) receptor subtype, which was the first to be cloned and characterized, has received considerable attention based on its purported role in the etiology and treatment of mood and anxiety disorders. 5-HT(1A) receptors function both at presynaptic (autoreceptor) and postsynaptic (heteroreceptor) sites. Recent research has implicated distinct roles for these two populations of receptors in mediating emotion-related behavior. New concepts as to how 5-HT(1A) receptors function to control serotonergic tone throughout life were highlights of the proceedings of the 2012 Serotonin Club Meeting in Montpellier, France. Here, we review recent findings and current perspectives on functional aspects of 5-HT(1A) auto- and heteroreceptors with particular regard to their involvement in altered anxiety and mood states.
authors: Semel Institute for Neuroscience & Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, United States.
authors: Stefanie C
authors: SC
authors: Altieri
authors: Alvaro L
authors: AL
authors: Garcia-Garcia
authors: E David
authors: ED
authors: Leonardo
authors: Anne M
authors: AM
authors: Andrews
mesh_terms: D000339:Affect / Q000502:physiology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001008:Anxiety Disorders / Q000209:etiology*; D017660:Autoreceptors / Q000502:physiology; D004195:Disease Models, Animal; D025461:Feedback, Physiological / Q000502:physiology; D005544:Forecasting; D006803:Human Development / Q000502:physiology; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D017397:Prefrontal Cortex / Q000502:physiology; D044282:Receptor, Serotonin, 5-HT1A / Q000502:physiology*; D058829:Serotonin 5-HT1 Receptor Antagonists / Q000494:pharmacology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000928:Antidepressive Agents; D017660:Autoreceptors; D058829:Serotonin 5-HT1 Receptor Antagonists; D044282:Receptor, Serotonin, 5-HT1A