title: Tris(azidoethyl)amine hydrochloride; a versatile reagent for synthesis of functionalized dumbbell oligodeoxynucleotides.
abstract: Triazole-cross-linked oligodeoxynucleotides were synthesized using the Cu(I) catalyzed alkyne-azide cycloaddition with tris(azidoethyl)amine hydrochloride and oligodeoxynucleotides possessing N-3-(propargyl)thymidine at both the 3'- and 5'-termini. Further installation of a functional molecule to the dumbbell oligodeoxynucleotides was achieved by utilizing the remaining azide group.
authors: Kita-12, Nishi-6, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. ichikawa@pharm.hokudai.ac.jp
authors: Satoshi
authors: S
authors: Ichikawa
authors: Hideaki
authors: H
authors: Ueno
authors: Takuya
authors: T
authors: Sunadome
authors: Kousuke
authors: K
authors: Sato
authors: Akira
authors: A
authors: Matsuda
mesh_terms: D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry*
chemical_list: D001386:Azides; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D014230:Triazoles; D003300:Copper