title: Chaetoglobosins and azaphilones produced by Canadian strains of Chaetomium globosum isolated from the indoor environment.
abstract: Chaetomium globosum is one of the most common species of fungi found growing on damp building materials in North America and Europe. At doses that could be experienced in a building with some mould damage, exposure to metabolites from other fungi results in inflammatory changes in vivo and in vitro. This research requires knowledge of the dominant toxins produced by fungal strains from the built environment and characterization of pure compounds for toxicity testing. We examined 25 strains of C. globosum isolated from the built environment in Canada. In varying amounts, these strains primarily produced chaetoglobosin A, C and F, chaetomugilin D, and chaetoviridin A. Spectroscopic data of the major isolated compounds are provided. Previous studies reported a number of metabolites from this species that we did not find. However, this appears to be due to misidentifications of the fungi they examined as well as problems with the analytical methods used. In addition, our data support the use of metabolite profiles for resolving the taxonomy of some economically important Chaetomium species.
authors: Ottawa Carleton Institute of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada.
authors: David R
authors: DR
authors: McMullin
authors: Mark W
authors: MW
authors: Sumarah
authors: J David
authors: JD
authors: Miller
mesh_terms: D001578:Benzopyrans / Q000737:chemistry / Q000378:metabolism*; D002170:Canada; D002597:Chaetomium / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D003252:Construction Materials / Q000382:microbiology*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D004783:Environmental Microbiology; D026121:Indole Alkaloids / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D010860:Pigments, Biological / Q000737:chemistry / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D013057:Spectrum Analysis
chemical_list: D001578:Benzopyrans; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D026121:Indole Alkaloids; D010860:Pigments, Biological; C494154:azaphilone; C019290:chaetoglobosins