title: Lamotrigine augmentation in premenstrual dysphoric disorder:  a case report.
abstract: Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome, characterized by depressive, anxious, and somatic symptoms, associated to a significant reduction in social functioning and quality of life. Although selective serotonin reuptake inhibitors (SSRIs) and oral contraceptives show a substantial effectiveness in PMDD, a wide percentage of women affected by PMDD do not respond to those first-line treatments. We present the case of a 42-year-old woman, affected by a disabling form of PMDD, who partially responded to an SSRI treatment and significantly improved after an add-on therapy with lamotrigine. We therefore suggest that lamotrigine may be an efficacious and safe augmentation strategy in severe PMDD cases showing unsatisfactory or partial response to SSRI treatments.
authors: Department of Neuroscience and Imaging, Chair of Psychiatry, G d'Annunzio University of Chieti, Chieti, Italy. g.sepede@unich.it
authors: Gianna
authors: G
authors: Sepede
authors: Giovanni
authors: G
authors: Martinotti
authors: Francesco
authors: F
authors: Gambi
authors: Rosa Maria
authors: RM
authors: Salerno
authors: Massimo
authors: M
authors: Di Giannantonio
mesh_terms: D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D011293:Premenstrual Syndrome / Q000175:diagnosis* / Q000188:drug therapy* / Q000523:psychology; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*; D014227:Triazines / Q000008:administration & dosage*
chemical_list: D000077213:Lamotrigine; D017367:Selective Serotonin Reuptake Inhibitors; D014227:Triazines