title: A robust route to enzymatically functional, hierarchically self-assembled peptide frameworks.
abstract: The addition of enzyme biofunctionality to self-assembling peptide nanofibers is challenging since such additions can inhibit functionality or self-assembly. We introduce a method for peptide nanofiber enzyme functionalization, demonstrated by the attachment of a polymerization synthase to peptide nanofibers. The enzyme generates a biocompatible, biodegradable biopolyester coat on the fibers with applicablity in medical engineering. This approach provides a template for generation of functional bionanomaterials.
authors: Biological and Soft Systems, Cavendish Laboratory, University of Cambridge, CB3 0HE, UK.
authors: S
authors: S
authors: Sangiambut
authors: K
authors: K
authors: Channon
authors: N M
authors: NM
authors: Thomson
authors: S
authors: S
authors: Sato
authors: T
authors: T
authors: Tsuge
authors: Y
authors: Y
authors: Doi
authors: E
authors: E
authors: Sivaniah
mesh_terms: D020341:Absorbable Implants; D040761:Biomimetic Materials / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D010453:Peptide Synthases / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D046911:Macromolecular Substances; D010455:Peptides; D010453:Peptide Synthases