title: Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.
abstract: HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.
authors: National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
authors: Nichole R
authors: NR
authors: Klatt
authors: Lauren A
authors: LA
authors: Canary
authors: Xiaoyong
authors: X
authors: Sun
authors: Carol L
authors: CL
authors: Vinton
authors: Nicholas T
authors: NT
authors: Funderburg
authors: David R
authors: DR
authors: Morcock
authors: Mariam
authors: M
authors: Quiñones
authors: Clayton B
authors: CB
authors: Deming
authors: Molly
authors: M
authors: Perkins
authors: Daria J
authors: DJ
authors: Hazuda
authors: Michael D
authors: MD
authors: Miller
authors: Michael M
authors: MM
authors: Lederman
authors: Julie A
authors: JA
authors: Segre
authors: Jeffrey D
authors: JD
authors: Lifson
authors: Elias K
authors: EK
authors: Haddad
authors: Jacob D
authors: JD
authors: Estes
authors: Jason M
authors: JM
authors: Brenchley
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003131:Combined Modality Therapy; D019587:Dietary Supplements; D004195:Disease Models, Animal; D041981:Gastrointestinal Tract / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000628:therapy; D006801:Humans; D008254:Macaca nemestrina; D056692:Prebiotics; D019936:Probiotics / Q000008:administration & dosage*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology* / Q000628:therapy*; D059467:Transcriptome
chemical_list: D000276:Adjuvants, Immunologic; D044966:Anti-Retroviral Agents; D056692:Prebiotics