title: Deficits in sequential processing manifest in motor and linguistic tasks in a multigenerational family with childhood apraxia of speech.
abstract: The purpose of this study was to evaluate a global deficit in sequential processing as candidate endophenotypein a family with familial childhood apraxia of speech (CAS). Of 10 adults and 13 children in a three-generational family with speech sound disorder (SSD) consistent with CAS, 3 adults and 6 children had past or present SSD diagnoses. Two preschoolers with unremediated CAS showed a high number of sequencing errors during single-word production. Performance on tasks with high sequential processing loads differentiated between the affected and unaffected family members, whereas there were no group differences in tasks with low processing loads. Adults with a history of SSD produced more sequencing errors during nonword and multisyllabic real word imitation, compared to those without such a history. Results are consistent with a global deficit in sequential processing that influences speech development as well as cognitive and linguistic processing.
authors: Department of Speech and Hearing Sciences, University of Washington, Seattle, WA 98195, USA. bvpeter@u.washington.edu
authors: Beate
authors: B
authors: Peter
authors: Le
authors: L
authors: Button
authors: Carol
authors: C
authors: Stoel-Gammon
authors: Kathy
authors: K
authors: Chapman
authors: Wendy H
authors: WH
authors: Raskind
mesh_terms: D000293:Adolescent; D000328:Adult; D001072:Apraxias / Q000235:genetics* / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D003265:Contingent Negative Variation; D005192:Family Health; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000235:genetics* / Q000503:physiopathology*; D008037:Linguistics; D008297:Male; D008568:Memory / Q000502:physiology; D010375:Pedigree; D013060:Speech / Q000502:physiology*; D013064:Speech Disorders / Q000235:genetics* / Q000503:physiopathology*; D013068:Speech Production Measurement; D055815:Young Adult