title: Bioavailability of the Fusarium toxin deoxynivalenol (DON) from wheat straw and chaff in pigs.
abstract: Fusarium infections do not only affect the grain, but also the rest of the plant, which result in contamination of plants with the mycotoxin deoxynivalenol (DON). The bioavailability of DON may be influenced by the matrix due to the differences in nutrient composition between grain and straw, particularly the high fibre component in straw. The experiment was carried out by exposing 18 male castrated pigs (30-40 kg live weight) with a single dose of DON from wheat grain, straw and chaff in the diet. The courses of DON serum concentrations were evaluated using toxicokinetic methods. The absorption of DON was not influenced by the source of DON. The invasion half-life of DON from grain, straw and chaff amounted to 0.76, 0.77 and 0.48 h, respectively, and were not significantly different. The elimination of DON was also not affected by the DON source. The bioavailability of DON, calculated by the dose corrected area under the curve of the serum-DON-concentrations, amounted to 81.9, 87.3 and 109.8% for straw, grain and chaff, respectively, without significant differences. Thus, the uptake of DON from straw may contribute comparably to the overall exposure of animals.
authors: Institute of Animal Nutrition, Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Braunschweig, Germany.
authors: Dirk
authors: D
authors: Rohweder
authors: Susanne
authors: S
authors: Kersten
authors: Hana
authors: H
authors: Valenta
authors: Sarah
authors: S
authors: Sondermann
authors: Margit
authors: M
authors: Schollenberger
authors: Winfried
authors: W
authors: Drochner
authors: Sven
authors: S
authors: Dänicke
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001682:Biological Availability; D004032:Diet / Q000662:veterinary; D005670:Fusarium / Q000737:chemistry*; D008297:Male; D018547:Plant Stems / Q000737:chemistry*; D013552:Swine / Q000097:blood*; D014255:Trichothecenes / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity; D014908:Triticum / Q000737:chemistry*
chemical_list: D014255:Trichothecenes; C007262:deoxynivalenol