title: Formation of alternative proteasomes: same lady, different cap?
abstract: The 26S proteasome is thought to be a homogenous complex, consisting of a 20S proteolytic core and a 19S regulatory particle that is required for its activation. Two groups have recently reported the activation of archeal 20S by a p97-related double-ring AAA+ ATPase complex, in a similar fashion to that reported for 19S. Since p97 is found in eukaryotes, the existence of a parallel setting in higher organisms is intriguing. Herein, we present supporting data and hypothesize that in eukaryotes, p97 and CSN form a promiscuous, hence hard-to-detect, "alternative cap", enabling the prompt and precise elimination of particular substrates.
authors: Department of Biology and Environment, Faculty of Natural Sciences, University of Haifa at Oranim, Tivon 36006, Israel. elahpic@research.haifa.ac.il
authors: Elah
authors: E
authors: Pick
authors: Tali S
authors: TS
authors: Berman
mesh_terms: D000818:Animals; D019843:Archaeal Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D010450:Endopeptidases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D019143:Evolution, Molecular; D006801:Humans; D017020:Methanosarcina / Q000201:enzymology; D008958:Models, Molecular; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D021122:Protein Subunits / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D013822:Thermoplasma / Q000201:enzymology; D054875:Ubiquitination
chemical_list: D019843:Archaeal Proteins; D021122:Protein Subunits; D010450:Endopeptidases; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease; C093138:proteasome, Thermoplasma