title: Comparision of inflammatory biomarkers for detection of coronary stenosis in patients with stable coronary artery disease.
abstract: BACKGROUND
  The objective of the current study was to evaluate the role of various inflammatory biomarkers in detection of coronary stenosis in patients with stable coronary artery disease (CAD) and healthy people.
  
  
  METHODS
  A total of 111 patients with stable coronary artery disease, and 66 healthy subjects were enrolled in the study. Serum levels of lipoprotein-associated-phospholipase A2 (Lp-PLA2), high-sensitivity C-reactive protein (hs-CRP), and myeloperoxidase (MPO) were measured to compare patient and control groups.
  
  
  RESULTS
  Baseline characteristics were similar between healthy and patient groups, with the exception of age. ANCOVA and log-transformed data of inflammatory biomarkers revealed that, Lp-PLA2 (p < 0.001) and hs-CRP (p < 0.05) levels in all patient groups were significantly higher than in the control group. Conversely, there was no significant difference in MPO levels among groups.
  
  
  CONCLUSIONS
  In stable CAD patients, serum Lp-PLA2 levels are more compatible than hs-CRP and MPO levels in the detection of coronary stenosis.
authors: Department of Chemistry, Faculty of Art and Science, Recep Tayyp Erdogan University, Rize, Turkey.
authors: H A
authors: HA
authors: Uydu
authors: M
authors: M
authors: Bostan
authors: A
authors: A
authors: Yilmaz
authors: A
authors: A
authors: Demir
authors: M
authors: M
authors: Atak
authors: Ö
authors: Ö
authors: Satiroglu
authors: A
authors: A
authors: Temiz
authors: Y
authors: Y
authors: Cicek
authors: T
authors: T
authors: Erdogan
authors: M
authors: M
authors: Cetin
authors: A
authors: A
authors: Canga
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood*; D023921:Coronary Stenosis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D002097:C-Reactive Protein; D009195:Peroxidase; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase