title: Antibacterial-coated suture in reducing surgical site infection in breast surgery: a prospective study.
abstract: Background. To reduce the incidence of microbial colonization of suture material, Triclosan- (TC-)coated suture materials have been developed. The aim of this study was to assess the incidence of suture-related complications (SRC) in breast surgery with and without the use of TC-coated sutures. Methods. We performed a study on two consecutive periods: 92 patients underwent breast surgery with conventional sutures (Group 1) and 98 with TC-coated sutures (Group 2). We performed subgroups analyses and developed a model to predict SRC in Group 1 and tested its clinical efficacy in Group 2 using a nomogram-based approach. Results. The SRC rates were 13% in Group 1 and 8% in Group 2. We found that some subgroups may benefit from TC-coated sutures. The discrimination obtained from a logistic regression model developed in Group 1 and based on multifocality, age and axillary lymphadenectomy was 0.88 (95% CI 0.77-0.95) (P < 10(-4)). There was a significant difference in Group 2 between predicted probabilities and observed percentages (P < 10(-5)). The predicted and observed proportions of complications in the high-risk group were 38% and 13%, respectively. Conclusion. This study used individual predictions of SRC and showed that using TC-coated suture may prevent SRC. This was particularly significant in high-risk patients.
authors: Service de Gynécologie-Obtétrique, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, CancerEst, Université Pierre et Marie Curie-Paris 6 75020 Paris, France.
authors: Enora
authors: E
authors: Laas
authors: Cécile
authors: C
authors: Poilroux
authors: Corinne
authors: C
authors: Bézu
authors: Charles
authors: C
authors: Coutant
authors: Serge
authors: S
authors: Uzan
authors: Roman
authors: R
authors: Rouzier
authors: Elisabeth
authors: E
authors: Chéreau