title: Effect of carnosine and related compounds on proliferation of cultured rat pheochromocytoma PC-12 cells.
abstract: The study was undertaken to determine the mechanism of carnosine effect on cell proliferation. We studied the effect of carnosine and its derivatives on cell cycle progression in cultured rat pheochromocytoma cells (PC-12). It was found that 48-h incubation of PC-12 cells with carnosine in concentrations of 10-50 mM led to deceleration of cell proliferation, reduction of G0/G1 peak, and accumulation of S- and G2/M-phase cells. Methylation of the carnosine molecule by 1N-position of the imidazole ring potentiated its effect on cell proliferation. Acetylation of the carnosine molecule by free β-amino group attenuated its effect.
authors: Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia. julie_ribakova@yahoo.com
authors: Yu S
authors: YS
authors: Rybakova
authors: A A
authors: AA
authors: Boldyrev
mesh_terms: D000818:Animals; D000861:Anserine / Q000494:pharmacology*; D002336:Carnosine / Q000031:analogs & derivatives / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D018797:Cell Cycle Proteins; D002455:Cell Division / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats
chemical_list: D018797:Cell Cycle Proteins; D002336:Carnosine; D000861:Anserine