title: Complete mole in a dichorionic twin pregnancy after intracytoplasmic sperm injection.
abstract: A dichorionic twin pregnancy with complete hydatidiform mole and coexistent fetus is a rare and challenging situation, whose pathogenesis has not been yet fully understood. We present a case of a 39-year-old woman who underwent intracytoplasmic sperm injection with two embryos transfer. The 12-week gestation ultrasound examination revealed normal fetus and placenta with features of hydatidiform mole, leading to pregnancy termination. Autopsy and histological examinations diagnosed a complete mole coexisting with a normal fetus, and the genetic analysis showed a diploid fetus with biparental genome and molar tissue with paternal diploidy. This case highlighted that complete molar pregnancies may still occur even though pregnancy is achieved after intracytoplasmic sperm injection. A review of the literature was performed by collecting data from the few similar reported cases and by commenting on the pathogenesis of this rare condition.
authors: Serviço de Ginecologia e Obstetrícia, Centro Hospitalar de São João do Porto, Portugal.
authors: Tiago José Santos de Matos
authors: TJ
authors: Ferraz
authors: Carla Maria Magno
authors: CM
authors: Bartosch
authors: Carla Maria Almeida
authors: CM
authors: Ramalho
authors: Filipa Abreu Gomes de
authors: FA
authors: Carvalho
authors: Berta Cecília Campos Lima de
authors: BC
authors: Carvalho
authors: Otília Gonçalves Bento Cavaleiro
authors: OG
authors: Brandão
authors: Nuno Aires Mota Mendonça
authors: NA
authors: Montenegro
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*; D059285:Pregnancy, Twin; D020554:Sperm Injections, Intracytoplasmic; D014594:Uterine Neoplasms / Q000473:pathology*