title: Serum cytokines correlated with the disease severity of generalized pustular psoriasis.
abstract: To characterize serum biomarkers reflecting the severity of generalized pustular psoriasis (GPP), we measured multiple cytokine/chemokine levels in 39 serum samples from 6 cases with GPP during the course of the disease. Serum levels of IL-4, IL-8, CXCL1 and CCL3 were positively correlated with the severity scores of GPP, white blood cell counts and serum C-reactive protein levels. Serum levels of IL-1β, IL-1ra, IL-6, IL-10, IL-12p70, IL-18, IL-22, IFN-γ and VEGF showed strong positive correlations (r>0.4, p<0.01) with all those 3 clinical markers. Of those, IL-10 and IL-22 were significantly decreased after treatment in parallel with the GPP score and therefore those two serum cytokines might be useful to evaluate the efficacy of treatment for GPP.
authors: Department of Dermatology, Hyogo College of Medicine, Hyogo, Japan.
authors: Masaaki
authors: M
authors: Yamamoto
authors: Yasutomo
authors: Y
authors: Imai
authors: Yoshiko
authors: Y
authors: Sakaguchi
authors: Takashi
authors: T
authors: Haneda
authors: Kiyofumi
authors: K
authors: Yamanishi
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis* / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D018925:Chemokines / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D040081:Protein Array Analysis; D011565:Psoriasis / Q000097:blood* / Q000175:diagnosis; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D002097:C-Reactive Protein