title: Cytoprotective effects of graphene oxide for mammalian cells against internalization of exogenous materials.
abstract: To date, graphene oxide (GO), an oxidized version of graphene, has been utilized in many research areas including bioapplications such as drug delivery and bioanalysis. Unlike other spherical or polygonal nanomaterials, GO exhibits a sheet-like structure, which in itself suggests interesting applications based on its shape. Here we show that GO can protect cells from internalization of toxic hydrophobic molecules, nanoparticles, and nucleic acids such as siRNA and plasmid DNA by interacting with cell surface lipid bilayers without noticeably reducing cell viability. Furthermore, the cytoprotective effect of GO against the internalization of extracellular materials enabled spatial control over gene transfection through region-selective gene delivery only into GO-untreated cells, and not into the GO-treated cells.
authors: Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
authors: Hee-Kyung
authors: HK
authors: Na
authors: Mi-Hee
authors: MH
authors: Kim
authors: Jieon
authors: J
authors: Lee
authors: Young-Kwan
authors: YK
authors: Kim
authors: Hongje
authors: H
authors: Jang
authors: Kyung Eun
authors: KE
authors: Lee
authors: Hyerim
authors: H
authors: Park
authors: Won Do
authors: WD
authors: Heo
authors: Hyesung
authors: H
authors: Jeon
authors: Insung S
authors: IS
authors: Choi
authors: Younghoon
authors: Y
authors: Lee
authors: Dal-Hee
authors: DH
authors: Min
mesh_terms: D019610:Cytoprotection / Q000187:drug effects* / Q000502:physiology*; D004705:Endocytosis / Q000187:drug effects*; D006108:Graphite / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D008422:Materials Testing; D049329:Nanostructures / Q000008:administration & dosage*; D010087:Oxides / Q000494:pharmacology*
chemical_list: D010087:Oxides; D006108:Graphite