title: IL-17 gene polymorphism is associated with chronic periodontitis and peri-implantitis in Iranian patients: a cross-sectional study.
abstract: Periodontal disease (PD) and peri-implantitis (PI) are characterized by an immune response leading to destructive inflammation. The prominent impact of genetic factors on periodontitis has been previously evaluated and IL-17 has found to play a critical role in this process. This cytokine has a controversial behavior. This study aimed at finding out whether the polymorphism of this cytokine plays a significant role in chronic periodontitis (CP) and PI or it is just a pro-inflammatory regulatory cytokine. Fresh human blood samples were obtained and three main genotypes were traced carefully. The samples were transferred into 96-well plates and sent to KBioscience Institute in the United Kingdom for genotyping the polymorphism using Competitive Allele Specific PCR (KASP) technique. SPSS version19 software and chi-square and Kruskal-Wallis tests were used for statistical differences considering p-value less than 0.05. A significant difference was detected between the three groups in terms of specific SNP studied in this experiment (P = 0.00). The CC genotype of IL17 polymorphism (rs10484879) may contribute to the pathogenesis of peri-implantitis and periodontitis. The association of IL-17 polymorphism with PI and CP is a promising finding that may help in future similar studies on other ethnicities and larger study populations.
authors: Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Mahdi
authors: M
authors: Kadkhodazadeh
authors: Zahra
authors: Z
authors: Baghani
authors: Ahmad Reza
authors: AR
authors: Ebadian
authors: Navid
authors: N
authors: Youssefi
authors: Amir Reza
authors: AR
authors: Mehdizadeh
authors: Niloofar
authors: N
authors: Azimi
mesh_terms: D000483:Alleles; D016301:Alveolar Bone Loss / Q000235:genetics; D055113:Chronic Periodontitis / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics; D007492:Iran; D008297:Male; D057873:Peri-Implantitis / Q000235:genetics*; D010518:Periodontitis; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D044465:White People
chemical_list: D020381:Interleukin-17