title: ALTITUDE trial and dual RAS blockade: the alluring but soft science of the surrogate end point.
authors: Franz H
authors: FH
authors: Messerli
authors: Sripal
authors: S
authors: Bangalore
mesh_terms: D000577:Amides / Q000627:therapeutic use*; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D057239:Early Termination of Clinical Trials; D005650:Fumarates / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000150:complications* / Q000188:drug therapy; D012084:Renin-Angiotensin System / Q000187:drug effects; D000092502:Renin Inhibitors
chemical_list: D000577:Amides; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D005650:Fumarates; D007004:Hypoglycemic Agents; D000092502:Renin Inhibitors; C446481:aliskiren