title: The relationship between amniotic and newborn gastric fluid inflammatory mediators.
abstract: To determine whether the levels of inflammatory mediators in gastric fluid (GF) of a premature newborn are associated with those in amniotic fluid (AF) of the newborn's mother.
  
  
  METHODS
  Twenty-three pairs of pregnant women and their premature newborns <35 weeks gestation, born by Cesarean sections.
  
  
  METHODS
  Amniotic fluids and newborn gastric fluids were obtained from women during Cesarean section procedure. The mother-premature newborn dyads were retrospectively assessed to analyze the clinical and laboratory data. Concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α) and mannose-binding lectin (MBL) were compared between amniotic and newborn gastric fluids in each dyad.
  
  
  RESULTS
  Premature newborns and their mothers with funisitis had significantly higher median AF IL-6, TNF-α and GF IL-8 concentrations than those without funisitis (p = 0.022 for AF IL-6; p = 0.023 for AF TNF-α; p = 0.022 for GF IL-8). The concentrations of IL-6, IL-8, TNF-α and MBL in newborn GF were significantly correlated with those in AF in each dyad (p < 0.001, r = 0.872 for IL-6; p < 0.001, r = 0.851 for IL-8; p < 0.001, r = 0.768 for TNF-α; p < 0.001, r = 0.845 for MBL, respectively).
  
  
  CONCLUSIONS
  The levels of inflammatory mediators in GF of a premature newborn immediately after birth are strongly associated with those in AF of the newborn's mother.
authors: Department of Pediatrics, Jeju National University School of Medicine, Jeju, Republic of Korea. cardios@hanmail.net
authors: Young Don
authors: YD
authors: Kim
authors: Seung Chul
authors: SC
authors: Kim
authors: Kyung Un
authors: KU
authors: Choi
authors: Eun Sook
authors: ES
authors: Jun
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000276:immunology / Q000378:metabolism*; D002821:Chorioamnionitis / Q000378:metabolism; D005260:Female; D005750:Gastric Juice / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology / Q000378:metabolism*; D012189:Retrospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha