title: Straightforward synthesis of thiazoline-incorporated chalconoids from phenacyl halides.
abstract: A series of thiazoline-incorporated chalconoids, designed based on natural product scaffold, were efficiently synthesized via the reaction of 3-methyl-4-arylthiazole-2(3H)-thiones and appropriate phenacyl halides, and subsequent desulfurization. The starting 3-methyl-4- arylthiazole-2(3H)-thiones were also prepared from phenacyl halides. The structural aspects and (Z)-geometry of compounds were confirmed by IR and (1)H NMR spectral data. This chemistry provides a new library of compounds basically originated from phenacyl halides as building blocks, with potential activity for biomedical screening.
authors: Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
authors: Adile
authors: A
authors: Ayati
authors: Saeed
authors: S
authors: Emami
mesh_terms: D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D047188:Chalcones; D007659:Ketones; D013844:Thiazoles