title: Involvement of MarR and YedS in carbapenem resistance in a clinical isolate of Escherichia coli from China.
abstract: A carbapenem-resistant clinical isolate of Escherichia coli, which lacked OmpF and OmpC porins, carried a marR mutation and expressed a functional yedS, a normally nontranslated gene. MarR and YedS are described here as having effects on the ability of this strain to resist carbapenems. Additionally, expression of YedS was regulated by the small RNA MicF in a MarA-dependent way. These findings illustrate how broadly bacteria can mutate within a selective clinical setting, in this case, resistance to carbapenems, by altering three porin genes and one regulatory gene.
authors: Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts, USA.
authors: Douglas M
authors: DM
authors: Warner
authors: Qiwen
authors: Q
authors: Yang
authors: Valérie
authors: V
authors: Duval
authors: Minjun
authors: M
authors: Chen
authors: Yingchun
authors: Y
authors: Xu
authors: Stuart B
authors: SB
authors: Levy
mesh_terms: D015780:Carbapenems / Q000494:pharmacology; D002681:China; D004591:Electrophoresis, Polyacrylamide Gel; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects / Q000235:genetics; D008969:Molecular Sequence Data; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D015780:Carbapenems; D029968:Escherichia coli Proteins; C080004:MarR protein, E coli; D012097:Repressor Proteins