title: Inhibitory effects of acetylsalicylic acid on exocrine pancreatic carcinogenesis.
abstract: We investigated short (6 months) and long (12 months) term inhibitory effects of low (200 ppm) and high (400 ppm) dosages of acetylsalicylic acid (aspirin) on exocrine pancreatic carcinogenesis. It is known that exocrine pancreatic carcinogenesis can be detected by the presence of atypical acinar cell foci (AACF) in pancreas. We investigated possible inhibitory effects of acetylsalicylic acid in an azaserine-treated rat model. AACF were produced in rats by injection with azaserine according to previous studies. Our findings showed that the number, volume and diameter of pancreatic AACF were reduced after acetylsalicylic acid application. These observations suggest that acetylsalicylic acid may exert a protective effect against neoplastic development of pancreatic acinar cells in azaserine injected rats. Our findings corroborate reports in the literature concerning the effects of aspirin in reducing neoplastic development.
authors: Mustafa Kemal University, Faculty of Science, Department of Biology, Antakya.
authors: H
authors: H
authors: Yıldız
authors: H
authors: H
authors: Oztas
authors: D
authors: D
authors: Yıldız
authors: A
authors: A
authors: Koc
authors: E
authors: E
authors: Kalipci
mesh_terms: D061354:Acinar Cells / Q000187:drug effects / Q000473:pathology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D016588:Anticarcinogenic Agents / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage*; D001377:Azaserine / Q000037:antagonists & inhibitors / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity; D015179:Colorectal Neoplasms / Q000517:prevention & control; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D046790:Pancreas, Exocrine / Q000187:drug effects / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016588:Anticarcinogenic Agents; D002273:Carcinogens; D001377:Azaserine; D001241:Aspirin