title: Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation.
abstract: Intracellular Flightless I (Flii), a gelsolin family member, has been found to have roles modulating actin regulation, transcriptional regulation and inflammation. In vivo Flii can regulate wound healing responses. We have recently shown that a pool of Flii is secreted by fibroblasts and macrophages, cells typically found in wounds, and its secretion can be upregulated upon wounding. We show that secreted Flii can bind to the bacterial cell wall component lipopolysaccharide and has the potential to regulate inflammation. We now show that secreted Flii is present in both acute and chronic wound fluid.
authors: Women's and Children's Health Research Institute; North Adelaide; SA Australia ; Discipline of Paediatrics; The University of Adelaide; Adelaide, SA Australia.
authors: Allison J
authors: AJ
authors: Cowin
authors: Nazi
authors: N
authors: Lei
authors: Linda
authors: L
authors: Franken
authors: Nadira
authors: N
authors: Ruzehaji
authors: Carolin
authors: C
authors: Offenhäuser
authors: Zlatko
authors: Z
authors: Kopecki
authors: Rachael Z
authors: RZ
authors: Murray
keywords: Cathepsin D; Flightless I; Rab 7 and Stx11; late endosome; lysosome; secretion