title: Identifying analytics for high throughput bioprocess development studies.
abstract: In recent years, high throughput screening (HTS) studies have been increasingly employed as an integral element of bioprocess development activities. These studies are often limited by an analytical bottleneck; they generate multiple samples for analysis and the available analytical methods cannot always cope with the added analytical burden. A potential solution to this challenge is offered by the deployment of appropriate analytics. This article outlines features of analytical methods that affect their fit to high throughput (HT) applications. These are discussed for a range of analytics frequently used in bioprocess development studies of monoclonal antibodies. It then outlines how these features need to be considered in order to classify analytical methods in terms of their particular application in high throughput scenarios.
authors: The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
authors: Spyridon
authors: S
authors: Konstantinidis
authors: Simyee
authors: S
authors: Kong
authors: Nigel
authors: N
authors: Titchener-Hooker
mesh_terms: D000911:Antibodies, Monoclonal / Q000302:isolation & purification* / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D057166:High-Throughput Screening Assays / Q000379:methods*
chemical_list: D000911:Antibodies, Monoclonal