title: NASR: an effective approach for simultaneous noise and artifact suppression in NMR spectroscopy.
abstract: As a powerful tool for biological analysis, especially protein structure and dynamic studies, nuclear magnetic resonance (NMR) spectroscopy suffers from intrinsic low signal to nose ratio (SNR) and long acquisition time required for multidimensional (nD) experiments. Nonuniform sampling (NUS) can effectively speed up the experiment but often introduces artifacts into the spectrum. In addition to the development of highly sensitive hardware and NMR pulse sequences, data postprocessing is a relative simple and cost-effective method to improve the SNR and suppress the artifacts. In this work, we propose an effective approach for simultaneously suppressing noise and artifacts based on the resampling principle. The method is named NASR for short and tested using one-, two-, and three-dimensional (1D, 2D, and 3D) NMR spectra that were acquired using ether conventional or NUS (spiral and random, for 3D) approaches. The results reveal that the NASR is fast and applicable for improving the quality of 1D to nD NMR spectra with all kinds of sampling schemes.
authors: State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, 430071 Wuhan, China.
authors: Bin
authors: B
authors: Jiang
authors: Fan
authors: F
authors: Luo
authors: Yiming
authors: Y
authors: Ding
authors: Peng
authors: P
authors: Sun
authors: Xu
authors: X
authors: Zhang
authors: Ling
authors: L
authors: Jiang
authors: Conggang
authors: C
authors: Li
authors: Xi-an
authors: XA
authors: Mao
authors: Daiwen
authors: D
authors: Yang
authors: Chun
authors: C
authors: Tang
authors: Maili
authors: M
authors: Liu
mesh_terms: D016477:Artifacts; D002247:Carbon Isotopes / Q000737:chemistry; D002784:Cholesterol / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008962:Models, Theoretical; D009587:Nitrogen Isotopes / Q000737:chemistry; D059629:Signal-To-Noise Ratio; D025801:Ubiquitin / Q000737:chemistry / Q000378:metabolism
chemical_list: D002247:Carbon Isotopes; D009587:Nitrogen Isotopes; D025801:Ubiquitin; D002784:Cholesterol