title: Cu-catalyzed selective mono-N-pyridylation: direct access to 2-aminoDMAP/sulfonamides as bifunctional organocatalysts.
abstract: Direct and selective mono-N-pyridylation of trans-(R,R)-cyclohexane-1,2-diamine is described here. Facile preparation of a novel chiral 2-aminoDMAP core catalaphore via Cu catalysis has led to the development of various sulfonamide/2-aminoDMAPs as bifunctional acid/base organocatalysts (most in two steps overall), which have been shown to very effectively promote asymmetric conjugate addition of acetylacetone to trans-β-nitroolefins with good to excellent yields (87-93%) and enantioselectivites (up to 99%).
authors: Department of Chemistry, Middle East Technical University, 06800 Ankara, Turkey.
authors: Murat
authors: M
authors: Isik
authors: Cihangir
authors: C
authors: Tanyeli