title: PDCD4 functions as a suppressor for pT2a and pT2b stage gastric cancer.
abstract: Gastric cancer is one of the leading causes of cancer‑related mortality             worldwide. Loss of programmed cell death 4 (PDCD4) expression has been detected             in gastric cancer. However, the effects of PDCD4 on pT2 stage gastric cancer remain             unclear. The aim of this study was to identify the relationship between PDCD4             expression and clinicopathological features of patients with pT2 stage gastric             cancer. In the present study, 122 pT2 stage gastric cancer specimens were subclassified             as pT2a and pT2b stage. The levels of PDCD4 mRNA and protein in gastric cancer             tissues were lower compared to that in normal tissues as detected by real‑time             PCR and western blot analysis, respectively. In addition, both PDCD4 mRNA and             protein in pT2b stage gastric cancer were lower when compared to that in pT2a stage             gastric cancer. Finally, we used immuno-histochemistry to determine the protein             expression and analyzed the relationship between PDCD4 expression and the clinicopathological             features of pT2 stage gastric cancer patients. Cumulative survival rate of patients             with PDCD4 expression was significantly higher compared to the patients without             PDCD4 expression. PDCD4 expression in gastric cancer can be employed to indicate             a favorable prognosis for the disease outcome.
authors: Department of Surgical Oncology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, PR China.
authors: Peng-Tao
authors: PT
authors: Guo
authors: Dong
authors: D
authors: Yang
authors: Zhe
authors: Z
authors: Sun
authors: Hui-Mian
authors: HM
authors: Xu
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D000368:Aged; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000502:physiology*; D002453:Cell Cycle; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D016601:RNA-Binding Proteins / Q000502:physiology*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
chemical_list: D051017:Apoptosis Regulatory Proteins; C114487:PDCD4 protein, human; D016601:RNA-Binding Proteins