title: Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the Chinese population.
abstract: OBJECTIVE
  The aim of the present study was to investigate whether PON2 gene polymorphisms (rs7493, rs12026, rs12704796, rs7785846 and rs7786401) are associated with susceptibility to noise-induced hearing loss (NIHL) in the Chinese population.
  
  
  METHODS
  A case-control study was conducted using 615 cases selected without any restriction in age or sex and 644 controls who were matched with the cases in terms of age, gender and the intensity and duration of exposure to noise. Information on these subjects was gathered by questionnaires that were administered through face-to-face interviews by trained interviewers.
  
  
  RESULTS
  We found that the rs7493 CG + GG genotype (OR=1.36, 95% CI, 1.08-1.72), rs12026 CG + GG genotype (OR=1.34, 95% CI, 1.06-1.70), rs7785846 CT + TT genotype (OR=1.36, 95% CI, 1.07-1.71) and rs7786401 GT + TT genotype (OR=1.33, 95% CI, 1.05-1.68) were risk factors for NIHL.
  
  
  CONCLUSIONS
  PON2 gene polymorphisms may be associated with susceptibility to NIHL in the Chinese population
authors: Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, China.
authors: Xiu-Ting
authors: XT
authors: Li
authors: Xin
authors: X
authors: Li
authors: Fei-Fei
authors: FF
authors: Hu
authors: Huan-Xi
authors: HX
authors: Shen
authors: Jing-Lian
authors: JL
authors: Cao
authors: Zhong
authors: Z
authors: Li
authors: Zheng-Dong
authors: ZD
authors: Zhang
authors: Bao-Li
authors: BL
authors: Zhu
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000208:ethnology*; D006239:Haplotypes / Q000235:genetics; D006317:Hearing Loss, Noise-Induced / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D006801:Humans; D007407:Interviews as Topic; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009623:Noise, Occupational / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D043303:Aryldialkylphosphatase; C468411:PON2 protein, human