title: Introduction of histidine units using benzotriazolide activation.
abstract: N(α) -Boc-N(im) -(4-toluenesulfonyl-l-histidylbenzotriazole) enables convenient acylation of N-, O-, S-, and C-nucleophiles with no detectable racemization. We report efficient syntheses of novel histidine-containing di-, tri-, and tetra-peptides and models for the preparation of potentially biologically active histidine N-, O-, S-, and C-conjugates.
authors: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
authors: Kiran
authors: K
authors: Bajaj
authors: Siva S
authors: SS
authors: Panda
authors: Mohamed A
authors: MA
authors: Ibrahim
authors: Said A
authors: SA
authors: El-Feky
authors: Alan R
authors: AR
authors: Katritzky
mesh_terms: D006639:Histidine / Q000031:analogs & derivatives* / Q000737:chemistry*; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D014105:Tosyl Compounds / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D009842:Oligopeptides; D014105:Tosyl Compounds; D014230:Triazoles; D006639:Histidine