title: Effect of percutaneous transthoracic lung biopsy on oxidative metabolism in sheep.
abstract: This study aimed to assess the effect of percutaneous transthoracic lung biopsy on the  oxidative metabolism of sheep by measuring the oxidative stress markers of superoxide  dismutase (SOD), total glutathione (GSH-t), peroxidase (GSH-Px) and thiobarbituric acid  reactive substances (TBARS) in the red cells of these animals. Blood samples were collected  from 20 clinically healthy sheep prior to, and 30 min after, percutaneous transthoracic lung  biopsy. After biopsy, there was a significant decrease (p &lt; 0.05) in SOD and GSH-Px activity, with no significant change (p ≥ 0.05) in GSH-t and TBARS concentrations. These results showed that percutaneous transthoracic lung biopsy did not significantly affect the oxidative metabolism of sheep 30 min after the procedure, which may be used widely in this species  without causing serious tissue damage.
authors: Department of Veterinary Clinics, São Paulo State University, Brazil. andrezamedvet@yahoo.com.br
authors: Andreza A
authors: AA
authors: Silva
authors: Danilo O L
authors: DO
authors: Ferreira
authors: Bianca P
authors: BP
authors: Santarosa
authors: Adriano
authors: A
authors: Dias
authors: Débora C
authors: DC
authors: Damasceno
authors: Roberto C
authors: RC
authors: Gonçalves
mesh_terms: D000818:Animals; D001706:Biopsy / Q000009:adverse effects / Q000379:methods / Q000662:veterinary; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008168:Lung / Q000473:pathology*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D012756:Sheep / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione