title: Clinical significance of altered S100A2 expression in gastric cancer.
abstract: The S100A2 gene has been reported to be a putative tumor‑suppressor gene.             Nevertheless, overexpression of S100A2 has been found in certain types of cancer.             This study investigated S100A2 expression in tissue specimens of gastritis, intestinal             metaplasia, adenomatous dysplasia and gastric cancer to determine its association             with clinical features. A serial of tissue samples (gastritis, intestinal metaplasia,             adenomatous dysplasia and gastric cancer samples) were used for quantitative real-time             reverse transcriptase-polymerase chain reaction (qRT-PCR), western blotting and             immunohistochemical analyses of S100A2 expression. The data revealed that there             was a gradual loss of S100A2 expression from gastritis, intestinal metaplasia             and dysplasia to cancer tissue specimens (p<0.001). In gastric cancer samples,             loss of S100A2 expression was associated with increased tumor size, depth of invasion,             lymph node metastasis and a poor prognosis (p<0.001). However, the intestinal             type of gastric cancer expressed more S100A2 protein than the diffuse type (p<0.001).             In conclusion, data from the present study demonstrated that loss of S100A2 expression             contributes to gastric cancer development and progression; therefore, the determination             of S100A2 expression levels may help to predict the carcinogenesis and aggressiveness             of gastric cancer as well as patient survival.
authors: Department of General Surgery, Shengjing Hospital of China Medical University, and Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, Liaoning 110004, PR China.
authors: Ying
authors: Y
authors: Zhao
authors: Tian-Biao
authors: TB
authors: Zhang
authors: Qiang
authors: Q
authors: Wang
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000368:Aged; D045744:Cell Line, Tumor; D002630:Chemotactic Factors / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D005756:Gastritis / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008679:Metaplasia / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D009418:S100 Proteins / Q000235:genetics* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D002630:Chemotactic Factors; D009418:S100 Proteins; C098997:S100A2 protein, human