title: Nuclear receptors in herb-drug interactions.
abstract: Widespread usage of herbs as supplements or medicines raises the potential of herb-drug interactions (HDIs). Basically, HDIs occur by pharmacokinetic and/or pharmacodynamic pathways. Nuclear receptors (NRs) are a class of transcription factors whose role in drug interactions has been defined. A large number of herbs activate NRs, resulting in HDIs. NR-mediated HDIs are similar to drug-drug interactions, but are more complicated because of the presence of multiple compounds in herbs. Dosage and therapeutic sequence as well as various other factors, including the patient's gender, age, and genetic makeup, may affect outcomes of NR-mediated HDIs.
authors: Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
authors: Madhav
authors: M
authors: Sachar
authors: Xiaochao
authors: X
authors: Ma
mesh_terms: D004347:Drug Interactions; D041743:Herb-Drug Interactions; D006801:Humans; D028321:Plant Preparations / Q000493:pharmacokinetics / Q000494:pharmacology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*
chemical_list: D028321:Plant Preparations; D018160:Receptors, Cytoplasmic and Nuclear