title: [Volatile anaesthesias' molecular biological course of action].
abstract: Anaesthesia is extensively used worldwide and in Denmark alone more than 400,000 anaesthesias are performed each year. In spite of that the molecularly mechanism of anaesthesia has not been proven. Hypotheses have been suggested (lipid versus protein theory), but none has yet been able to explain the whole mechanism. Molecular targets for volatile anaesthetics (e.g. potassium and calcium channels) affected areas in the central nervous system and the impact on the cerebral metabolism versus the cerebral blood flow are discussed.
authors: Kardiologisk Klinik, Hjertecentret, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark. helle.soholm@gmail.com
authors: Helle
authors: H
authors: Søholm
authors: Niels Vidiendal
authors: NV
authors: Olsen
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D000077335:Desflurane; D006801:Humans; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D008738:Methyl Ethers / Q000494:pharmacology*; D009609:Nitrous Oxide / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D007473:Ion Channels; D008738:Methyl Ethers; D015221:Potassium Channels; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane; D009609:Nitrous Oxide