title: Direct catalytic asymmetric alkynylation of ketoimines.
abstract: An efficient protocol for direct catalytic alkynylation of ketoimines is described. The simultaneous activation of a soft Lewis basic terminal alkyne and a ketoimine bearing a thiophosphinoyl group by soft Lewis acid Cu(I) is crucial for high conversion. The reaction can be rendered asymmetric with a chiral bisphosphine ligand (S,S)-Ph-BPE.
authors: Institute of Microbial Chemistry (BIKAKEN), Tokyo 3-14-23 Kamiosaki, Tokyo 141-0021, Japan.
authors: Liang
authors: L
authors: Yin
authors: Yasunari
authors: Y
authors: Otsuka
authors: Hisashi
authors: H
authors: Takada
authors: Shinsuke
authors: S
authors: Mouri
authors: Ryo
authors: R
authors: Yazaki
authors: Naoya
authors: N
authors: Kumagai
authors: Masakatsu
authors: M
authors: Shibasaki
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007097:Imines / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D007097:Imines; D058116:Lewis Acids