title: Clinical Challenges in the Management of Leishmania/HIV Coinfection in a Nonendemic Area: A Case Report.
abstract: We report on a 37-year-old male HIV-positive patient with generalized cutaneous leishmaniasis undiagnosed for several years. Upon presentation, visceral leishmaniasis was diagnosed in addition to cutaneous manifestation of the disease. Over a period of three years, several different treatment regimens including liposomal amphotericin B, liposomal amphotericin B with miltefosine, liposomal amphotericin B with interferon, and pentamidine combined fluconazole and allopurinol were applied until Leishmania PCR from blood turned negative. This case supports the necessity of multidrug combinational and sequential therapy over a very prolonged period of time in severely immunosuppressed patients infected with Leishmania and highlights the tremendous individual but also economic burden of this disease.
authors: Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, 1090 Vienna, Austria.
authors: K
authors: K
authors: Grabmeier-Pfistershammer
authors: W
authors: W
authors: Poeppl
authors: P M
authors: PM
authors: Brunner
authors: K
authors: K
authors: Rappersberger
authors: A
authors: A
authors: Rieger