title: Impact of early blood pressure variability on stroke outcomes after thrombolysis: the SAMURAI rt-PA Registry.
abstract: OBJECTIVE
  The present study determines associations between early blood pressure (BP) variability and stroke outcomes after intravenous thrombolysis.
  
  
  METHODS
  In 527 stroke patients receiving intravenous alteplase (0.6 mg/kg), BP was measured 8 times within the first 25 hours. BP variability was determined as ΔBP (maximum-minimum), standard deviation (SD), coefficient of variation, and successive variation.
  
  
  RESULTS
  The systolic BP course was lower among patients with modified Rankin Scale (mRS) 0 to 1 than those without (P<0.001). Most of systolic BP variability profiles were significantly associated with outcomes. Adjusted odds ratios (95% confidence interval) per 10 mm Hg (or 10% for coefficient of variation) on symptomatic intracerebral hemorrhage were as follows: ΔBP, 1.33 (1.08-1.66); SD, 2.52 (1.26-5.12); coefficient of variation, 3.15 (1.12-8.84); and successive variation, 1.82 (1.04-3.10). The respective values were 0.88 (0.77-0.99), 0.73 (0.48-1.09), 0.77 (0.43-1.34), and 0.76 (0.56-1.03) for 3-month mRS 0 to 1; and 1.40 (1.14-1.75), 2.85 (1.47-5.65), 4.67 (1.78-12.6), and 1.99 (1.20-3.25) for death. Initial BP values before thrombolysis were not associated with any outcomes.
  
  
  CONCLUSIONS
  Early systolic BP variability was positively associated with symptomatic intracerebral hemorrhage and death after intravenous thrombolysis.
authors: Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka 565-8565, Japan.
authors: Kaoru
authors: K
authors: Endo
authors: Kazuomi
authors: K
authors: Kario
authors: Masatoshi
authors: M
authors: Koga
authors: Jyoji
authors: J
authors: Nakagawara
authors: Yoshiaki
authors: Y
authors: Shiokawa
authors: Hiroshi
authors: H
authors: Yamagami
authors: Eisuke
authors: E
authors: Furui
authors: Kazumi
authors: K
authors: Kimura
authors: Yasuhiro
authors: Y
authors: Hasegawa
authors: Yasushi
authors: Y
authors: Okada
authors: Satoshi
authors: S
authors: Okuda
authors: Michito
authors: M
authors: Namekawa
authors: Tetsuya
authors: T
authors: Miyagi
authors: Masato
authors: M
authors: Osaki
authors: Kazuo
authors: K
authors: Minematsu
authors: Kazunori
authors: K
authors: Toyoda
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D002543:Cerebral Hemorrhage / Q000453:epidemiology; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012042:Registries; D020521:Stroke / Q000188:drug therapy* / Q000503:physiopathology; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator