title: Assignments of human integrin α1I domain in the apo and Mg²⁺ bound states.
abstract: The α1β1 integrin receptor binds to its main extracellular ligand, collagen, through an inserted domain in its α-subunit called the αI domain (αI). αI contains a metal binding site that allows collagen to coordinate to the domain through a divalent metal ion. Here we report the backbone assignments of the apo and Mg(2+) bound state of the isolated human α1I and the chemical shift changes resulting from metal coordination.
authors: Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC, 3052, Australia.
authors: Yanni K-Y
authors: YK
authors: Chin
authors: Stephen
authors: S
authors: Headey
authors: Biswaranjan
authors: B
authors: Mohanty
authors: Jonas
authors: J
authors: Emsley
authors: Jamie S
authors: JS
authors: Simpson
authors: Martin J
authors: MJ
authors: Scanlon
mesh_terms: D001059:Apoproteins / Q000737:chemistry*; D006801:Humans; D039423:Integrin alpha1 / Q000737:chemistry*; D008274:Magnesium / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
chemical_list: D001059:Apoproteins; D039423:Integrin alpha1; D008274:Magnesium