title: The cost of cytoreductive surgery and perioperative intraperitoneal chemotherapy  in the treatment of peritoneal malignancy in one Greek institute.
abstract: OBJECTIVE
  Cytoreductive surgery and perioperative intraperitoneal chemotherapy in the treatment of patients with peritoneal malignancy is expensive. The purpose of this study was to estimate the current cost of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy and identify the most significant related parameters in one center in Greece.
  
  
  METHODS
  A retrospective economic study was carried out on 105 patients that underwent 108 cytoreductive operations and hyperthermic intraoperative peritoneal chemotherapy (HIPEC) from 2006-2011 for peritoneal malignancy. The economic cost included the daily cost of hospital bed occupancy, the daily cost of occupancy in the intensive care unit (ICU), the expenditures (materials and drugs), and the preoperative, intraoperative, and postoperative examinations.
  
  
  RESULTS
  The mean length of stay in the ICU and the mean hospitalization time was 5 and 23 days, respectively. The hospital mortality and morbidity was 5.6% (6 patients) and 48.17percnt; respectively. The mean cost of treatment was 15677.3±11910.6 euros (range=4258,47-95990,87) per patient. Morbidity (p=0.009), and prolonged stay in the ICU (p<0.001) were the parameters that influenced independently the cost of treatment.
  
  
  CONCLUSIONS
  Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy is an expensive treatment. The economic cost is largely influenced by morbidity and the length of stay in the ICU.
authors: Department of Surgery, Didimotichon General Hospital, Didimotichon, Greece. atentes@did-hosp.gr
authors: A A
authors: AA
authors: Tentes
authors: N
authors: N
authors: Pallas
authors: O
authors: O
authors: Korakianitis
authors: C
authors: C
authors: Mavroudis
authors: A
authors: A
authors: Spiridonidou
authors: G
authors: G
authors: Zorbas
authors: S
authors: S
authors: Popidis
authors: N
authors: N
authors: Papadoniou
authors: V
authors: V
authors: Darladima
authors: A
authors: A
authors: Smyrnis
authors: C
authors: C
authors: Siopis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D017048:Health Care Costs; D006801:Humans; D006979:Hyperthermia, Induced; D007274:Injections, Intraperitoneal; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000191:economics / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents