title: Anti-tumor initiating potential of andrographolide in 7,12-dimethylbenz[a]anthracene induced hamster buccal pouch carcinogenesis.
abstract: The aim of the study was to investigate the chemopreventive potential of andrographolide in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral tumors developed in the buccal pouch of golden Syrian hamsters at a 100% incidence on painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Marked abnormalities in the status of detoxification enzymes, lipid perxodiation and antioxidants were noticed in hamsters treated with DMBA alone. Oral administration of andrographolide at a dose of 50 mg/ kg bw to hamsters treated with DMBA not only completely prevented the tumor formation but also restored the status of the above mentioned biomarkers. The present study thus demonstrates the chemopreventive potential of andrographolide in DMBA-induced hamster buccal pouch carcinogenesis, which is probably due to its antioxidant potential as well as modulating effect on xenobiotic metabolising enzymes during DMBA-induced oral carcinogenesis.
authors: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India. rasmanshisak@gmail.com
authors: S
authors: S
authors: Manoharan
authors: Arjun Kumar
authors: AK
authors: Singh
authors: K
authors: K
authors: Suresh
authors: K
authors: K
authors: Vasudevan
authors: R
authors: R
authors: Subhasini
authors: N
authors: N
authors: Baskaran
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism; D002273:Carcinogens / Q000633:toxicity; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D002374:Catalase / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D006224:Cricetinae; D004224:Diterpenes / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000187:drug effects / Q000378:metabolism; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D002273:Carcinogens; D004224:Diterpenes; C030419:andrographolide; D015127:9,10-Dimethyl-1,2-benzanthracene; D002374:Catalase; D013482:Superoxide Dismutase