title: BAG-1 expression in human meningioma and correlation with clinical characteristics.
abstract: The aim of this study is to investigate BAG-1 expression in human meningiomas and to assess its association with pathological and clinical characteristics. BAG-1 expression was analyzed in 158 specimens of meningiomas using immunohistochemical staining, and the results were graded according to the positivity ratio and the staining intensity. We examined the correlations between BAG-1 expression and the 2007 WHO pathological classification, peritumoral edema and postoperative recurrence. There were no significant differences in BAG-1 expression among meningioma subtypes within the same histopathologic grade, as well as between grades II and III. BAG-1 expression in grade I was much higher than in grade II (P < 0.05) or III (P < 0.01). BAG-1 expression was gradually decreased with increasing WHO pathologic classification (χ (2) = 141.49, P < 0.01), as well as with the increase in peritumoral edema (χ (2) = 43.93, P < 0.01) and postoperative recurrence (χ (2) = 55.13, P < 0.01). BAG-1 expression in meningioma depends upon WHO pathologic classification and is decreased in higher tumor classification. It is associated with heavier peritumoral edema and more postoperative recurrences.
authors: Department of Neurosurgery, Taizhou Municipal Hospital, Taizhou Medical College, Taizhou 318000, China. kerry2000year@163.com
authors: Kaiyu
authors: K
authors: Zhou
authors: Hanghuang
authors: H
authors: Jin
authors: Ting
authors: T
authors: Zhou
authors: Yongkang
authors: Y
authors: Luo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D004268:DNA-Binding Proteins / Q000032:analysis / Q000096:biosynthesis*; D004487:Edema / Q000150:complications; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008577:Meningeal Neoplasms / Q000145:classification / Q000378:metabolism* / Q000473:pathology*; D008579:Meningioma / Q000145:classification / Q000378:metabolism* / Q000473:pathology*; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology; D014157:Transcription Factors / Q000032:analysis / Q000096:biosynthesis*; D055815:Young Adult
chemical_list: C091732:BCL2-associated athanogene 1 protein; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D014157:Transcription Factors