title: Lactocepin as a protective microbial structure in the context of IBD.
abstract: Probiotics have been shown to exert beneficial effects in the context of different diseases including inflammatory bowel diseases (IBD). However, clinical use of probiotics is hampered by lack of understanding of the protective mechanisms and by safety concerns regarding the application of high numbers of live bacteria in patients. The identification of protective microbial structure-function relationships might enable to overcome these restraints and might lead to innovative therapies using the isolated active microbial structures. In our study, we aimed to characterize the protective mechanisms of VSL#3, a clinically relevant probiotic mixture in IBD. We found Lactobacillus casei/paracasei-produced lactocepin to selectively degrade pro-inflammatory chemokines, resulting in reduced immune cell infiltration and reduced inflammation in experimental IBD models. As immune cell recruitment is a major proinflammatory mechanism our findings suggest that lactocepin might be of broad therapeutic relevance in an array of inflammatory diseases like IBD, allergic skin inflammation and psoriasis.
authors: Chair for Biofunctionality, ZIEL Research Center for Nutrition and Food Science, Technische Universität München, Freising-Weihenstephan, Germany. gabriele.hoermannsperger@tum.de
authors: Gabriele
authors: G
authors: Hörmannsperger
authors: Marie-Anne
authors: MA
authors: von Schillde
authors: Dirk
authors: D
authors: Haller
mesh_terms: D000818:Animals; D016207:Cytokines / Q000037:antagonists & inhibitors*; D004195:Disease Models, Animal; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000517:prevention & control*; D007780:Lacticaseibacillus casei / Q000201:enzymology*; D008954:Models, Biological; D019936:Probiotics / Q000494:pharmacology*; D012697:Serine Endopeptidases / Q000378:metabolism*
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D012697:Serine Endopeptidases; C085783:lactocepin
keywords: CEP; IBD; chemokines; inflammation; lactocepin; probiotic; protease; prtP