title: Vascular miRNAs after balloon angioplasty.
abstract: MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression through translational repression or degradation of the target mRNA. Available strategies to improve stent patency lead to the risk of potential stent thrombosis. Modulation of miRs could be a promising means of reducing VSMC proliferation while increasing endothelial regeneration at the same time. Therefore, the goal of this review is to summarize recent experimental evidences on the role played by miRNAs in vascular remodeling, and particularly on VSMC phenotype switch and in endothelial cells, in response to vascular injury.
authors: Alberto Polimeni, Salvatore De Rosa, and Ciro Indolfi are at the Division of Cardiology, Magna Graecia University, URT Consiglio Nazionale delle Ricerche (CNR), Catanzaro 88100, Italy.
authors: Alberto
authors: A
authors: Polimeni
authors: Salvatore
authors: S
authors: De Rosa
authors: Ciro
authors: C
authors: Indolfi
mesh_terms: D000800:Angioplasty, Balloon / Q000009:adverse effects*; D042783:Endothelial Cells / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D010641:Phenotype; D014652:Vascular Diseases / Q000235:genetics* / Q000378:metabolism; D057772:Vascular System Injuries / Q000235:genetics* / Q000378:metabolism
chemical_list: D035683:MicroRNAs