title: No regional gray matter atrophy differences between pediatric- and adult-onset relapsing-remitting multiple sclerosis.
abstract: OBJECTIVE
  To investigate differences in region-specific gray matter (GM) damage between adults with pediatric-onset (PO) multiple sclerosis (MS) and adult-onset (AO) MS.
  
  
  METHODS
  Twenty-four relapsing-remitting (RR) adults with POMS (mean age = 35 years, mean disease duration = 18.4 years) were compared to 23 age-matched (AOA, mean age = 33.9 years, mean disease duration = 2.4 years) and 24 disease-duration matched (AOD, mean age = 45.9 years, mean disease duration = 18.5 years) RRMS adults who developed MS after the age of 18. Three-dimensional-T1-weighted images were acquired on a 1.5 T MRI. Image analysis was conducted using voxel-based morphometry (Statistical Parametric Mapping 8).
  
  
  RESULTS
  There were no regional GM atrophy differences between POMS and AODMS groups. No regional GM atrophy differences were found between POMS and AOAMS patients when disease duration was included as a covariate.
  
  
  CONCLUSIONS
  Regional GM differences were not found between POMS adults and MS controls matched for age or disease duration. Although of limited sample size, these findings suggest that there are no regional GM atrophy differences between RR POMS and AOMS.
authors: SUNY Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY; Buffalo Neuroimaging Analysis Center, Buffalo, NY.
authors: Katelyn
authors: K
authors: Donohue
authors: Jennifer L
authors: JL
authors: Cox
authors: Michael G
authors: MG
authors: Dwyer
authors: Rachel
authors: R
authors: Aliotta
authors: Melanie
authors: M
authors: Corwin
authors: Bianca
authors: B
authors: Weinstock-Guttman
authors: E
authors: E
authors: Ann Yeh
authors: Robert
authors: R
authors: Zivadinov
mesh_terms: D000328:Adult; D000375:Aging / Q000473:pathology*; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000473:pathology*; D012008:Recurrence; D012075:Remission, Spontaneous; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Multiple sclerosis; adult-onset; pediatric-onset; regional atrophy; voxel-based morphometry