title: Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology.
abstract: Mitochondria are a class of dynamic organelles that constantly undergo fission and fusion. Mitochondrial dynamics is governed by a complex molecular machinery and finely tuned by regulatory proteins. During cell injury or stress, the dynamics is shifted to fission, resulting in mitochondrial fragmentation, which contributes to mitochondrial damage and consequent cell injury and death. Emerging evidence has suggested a role of mitochondrial fragmentation in the pathogenesis of renal diseases including acute kidney injury and diabetic nephropathy. A better understanding of the regulation of mitochondrial dynamics and its pathogenic changes may unveil novel therapeutic strategies.
authors: Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.
authors: Ming
authors: M
authors: Zhan
authors: Craig
authors: C
authors: Brooks
authors: Fuyou
authors: F
authors: Liu
authors: Lin
authors: L
authors: Sun
authors: Zheng
authors: Z
authors: Dong
mesh_terms: D000818:Animals; D017209:Apoptosis; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D007674:Kidney Diseases / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology*; D063154:Mitochondrial Dynamics; D063306:Mitophagy; D015398:Signal Transduction