title: Graphene oxide based surface-enhanced Raman scattering probes for cancer cell imaging.
abstract: The intrinsic Raman signals provide the potential of graphene oxide (GO) for cellular imaging. Herein, novel surface-enhanced Raman scattering (SERS) labels based on GO-Ag nanoparticle (NP) composites are developed for fast cellular probing and imaging. The optimum SERS signals of the hybrids can be well controlled by adjusting the weight ratio between AgNO(3) and GO. Utilizing GO-AgNPs as the highly sensitive optical probes, fast SERS imaging of cancer cells is realized with a very short integration time of about 0.06 s per pixel. Furthermore, folic acid (FA) is covalently conjugated to GO for targeting specific cancer cells with folate receptors (FRs). Targeted SERS images can be acquired after 2 h incubation with FA-GO-AgNPs, which are specifically located on the surface of FR-positive cancer cells. In conclusion, the GO-based Raman probes mentioned here open up exciting opportunities for biomedical imaging.
authors: MOE Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
authors: Zhiming
authors: Z
authors: Liu
authors: Zhouyi
authors: Z
authors: Guo
authors: Huiqing
authors: H
authors: Zhong
authors: Xiaochu
authors: X
authors: Qin
authors: Mingming
authors: M
authors: Wan
authors: Biwen
authors: B
authors: Yang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity; D018613:Microscopy, Confocal; D010087:Oxides / Q000737:chemistry*; D013059:Spectrum Analysis, Raman
chemical_list: D010087:Oxides; D006046:Gold; D006108:Graphite