title: Biodegradable ferulic acid-containing poly(anhydride-ester): degradation products with controlled release and sustained antioxidant activity.
abstract: Ferulic acid (FA) is an antioxidant and photoprotective agent used in biomedical and cosmetic formulations to prevent skin cancer and senescence. Although FA exhibits numerous health benefits, physicochemical instability leading to decomposition hinders its efficacy. To minimize inherent decomposition, a FA-containing biodegradable polymer was prepared via solution polymerization to chemically incorporate FA into a poly(anhydride-ester). The polymer was characterized using nuclear magnetic resonance and infrared spectroscopies. The molecular weight and thermal properties were also determined. In vitro studies demonstrated that the polymer was hydrolytically degradable, thus providing controlled release of the chemically incorporated bioactive with no detectable decomposition. The polymer degradation products were found to exhibit antioxidant and antibacterial activity comparable to that of free FA, and in vitro cell viability studies demonstrated that the polymer is noncytotoxic toward fibroblasts. This renders the polymer a potential candidate for use as a controlled release system for skin care formulations.
authors: Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854, USA.
authors: Michelle A
authors: MA
authors: Ouimet
authors: Jeremy
authors: J
authors: Griffin
authors: Ashley L
authors: AL
authors: Carbone-Howell
authors: Wen-Hsuan
authors: WH
authors: Wu
authors: Nicholas D
authors: ND
authors: Stebbins
authors: Rong
authors: R
authors: Di
authors: Kathryn E
authors: KE
authors: Uhrich
mesh_terms: D000812:Anhydrides / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003373:Coumaric Acids / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D004952:Esters / Q000737:chemistry* / Q000494:pharmacology; D007739:L Cells; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008970:Molecular Weight; D011091:Polyesters / Q000138:chemical synthesis* / Q000494:pharmacology; D012996:Solutions / Q000737:chemistry
chemical_list: D000812:Anhydrides; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001672:Biocompatible Materials; D003373:Coumaric Acids; D004952:Esters; D011091:Polyesters; D012996:Solutions; C004999:ferulic acid