title: Antibacterial dihydrobenzopyran and xanthone derivatives from Garcinia cowa stem barks.
abstract: Two new compounds, garciniacowol (1) and garciniacowone (2) along with 15 knowncompounds were isolated from the stem barks of Garcinia cowa. Their structures weredetermined by intensive spectroscopic methods. The structure of 1 was a symmetrical dimericdihydrobenzopyran derivative, whereas the framework of 2 was a triprenyl caged-xanthoneprecursor. The antibacterial activities against Escherichia coli TISTR 780, Salmonellatyphimurium TISTR 292, Staphylococcus aureus TISTR 1466, and methicillin-resistant S. aureus(MRSA) SK1 of the isolated compounds were also evaluated. Compounds 2 and 9 exhibitedgood antibacterial activity against MRSA SK1 with the same minimum inhibitory concentration(MIC) value of 2 μg/mL. Moreover, compound 2 also showed good antibacterial activityagainst S. aureus with an MIC value of 2 μg/mL.
authors: Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand.
authors: Ittipon
authors: I
authors: Siridechakorn
authors: Wong
authors: W
authors: Phakhodee
authors: Thunwadee
authors: T
authors: Ritthiwigrom
authors: Trinop
authors: T
authors: Promgool
authors: Suwanna
authors: S
authors: Deachathai
authors: Sarot
authors: S
authors: Cheenpracha
authors: Uma
authors: U
authors: Prawat
authors: Surat
authors: S
authors: Laphookhieo
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002839:Chromans / Q000737:chemistry / Q000494:pharmacology*; D029760:Garcinia / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002839:Chromans; D044004:Xanthones