title: Acute leukemia showing t(8;22)(p11;q11), myelodysplasia, CD13/CD33/CD19 expression and immunoglobulin heavy chain gene rearrangement.
abstract: t(8;22)(p11;q11) is a rare but recurrent chromosome translocation that has been reported in 11 cases of myeloproliferative neoplasm or B-acute lymphoblastic leukemia. This translocation results in an in-frame fusion of FGFR1 on 8p11 and BCR on 22q11, and causes constitutive activation of the tyrosine kinase of the BCR/FGFR1 chimera protein. Here, we report the twelfth case of hematological tumor bearing t(8;22)(p11;q11). The bone marrow showed hypoplastic and tri-lineage dysplasia with 24.4% abnormal cells. The abnormal cells were not defined as myeloid or lymphoid morphologically, lacking a myeloperoxidase reaction. Flow cytometric analysis of the bone marrow cells revealed that the abnormal cells expressed CD13, CD33, CD34, and CD19, and that a fraction of the abnormal cells was positive for CD10. Southern blot analysis of the bone marrow cells showed rearrangement of the immunoglobulin heavy chain gene, a genetic hallmark of B-cell differentiation. Previously reported cases with t(8;22)(p11;q11) suggested an association between myeloid and B-lymphoid tumors, whereas other chromosome translocations involving FGFR1 on 8p11 showed a link between myeloid and T-lymphoid tumors. Our observation supports that t(8;22)(p11;q11) might define a dual myeloid and B-lymphoid disorder.
authors: Hematology/Oncology, Wakayama Medical University, Wakayama 641-8509, Japan.
authors: Masaya
authors: M
authors: Shimanuki
authors: Takashi
authors: T
authors: Sonoki
authors: Hiroki
authors: H
authors: Hosoi
authors: Jyuri
authors: J
authors: Watanuki
authors: Shogo
authors: S
authors: Murata
authors: Toshiki
authors: T
authors: Mushino
authors: Kodai
authors: K
authors: Kuriyama
authors: Shinobu
authors: S
authors: Tamura
authors: Kazuo
authors: K
authors: Hatanaka
authors: Nobuyoshi
authors: N
authors: Hanaoka
authors: Hideki
authors: H
authors: Nakakuma
mesh_terms: D018941:Antigens, CD19 / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D018826:CD13 Antigens / Q000378:metabolism; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007938:Leukemia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D051562:Proto-Oncogene Proteins c-bcr / Q000235:genetics; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics; D063268:Sialic Acid Binding Ig-like Lectin 3 / Q000378:metabolism; D014178:Translocation, Genetic
chemical_list: D018941:Antigens, CD19; D007143:Immunoglobulin Heavy Chains; D063268:Sialic Acid Binding Ig-like Lectin 3; C496348:FGFR1 protein, human; D051496:Receptor, Fibroblast Growth Factor, Type 1; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr; D018826:CD13 Antigens