title: Effect of using triclosan-impregnated suture for incisional closure on surgical site infection and inflammation following tibial plateau leveling osteotomy in dogs.
abstract: OBJECTIVE
  To compare surgical site infection and inflammation rates between the use of nonimpregnated (polydioxanone and poliglecaprone 25) versus triclosan-impregnated (polydioxanone and poliglecaprone 25) suture for incisional closure in dogs undergoing a standardized orthopedic procedure (tibial plateau leveling osteotomy [TPLO]).
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  283 dogs that underwent TPLO between November 2005 and December 2009.
  
  
  METHODS
  Medical records were reviewed for age; body weight; body condition score; use of propofol; perioperative and postoperative administration of antimicrobials; presence of a preoperative infection; use of a jig; technique of joint exploration; type of suture material (triclosan impregnated vs nonimpregnated) used to close the pes anserinus, subcutaneous layer, and subcuticular layer; use of staples or suture to close the skin; and surgery and anesthesia durations. The outcome variables were surgical site inflammation and infection.
  
  
  RESULTS
  Rates of infection and inflammation did not differ between surgeries for which triclosan-impregnated suture was used (n = 159 [8.8%, and 18.8%, respectively]) and those for which nonimpregnated suture was used (112 [10.7% and 15.2%, respectively]). The use of staples, compared with suture, to close the skin significantly decreased the inflammation rate.
  
  
  CONCLUSIONS
  Compared with in vitro conditions, in vivo conditions (where the environment is not controlled and triclosan may elute more quickly from the suture) may decrease the antibacterial effectiveness of triclosan-impregnated suture. On the basis of our findings, triclosan-impregnated sutures did not seem to provide an additional benefit for clinical use and cannot be strongly recommended for elective orthopedic procedures in veterinary medicine.
authors: Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL 61802, USA.
authors: Sean W
authors: SW
authors: Etter
authors: Guillaume R
authors: GR
authors: Ragetly
authors: R Avery
authors: RA
authors: Bennett
authors: David J
authors: DJ
authors: Schaeffer
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000517:prevention & control; D004285:Dogs; D007249:Inflammation / Q000517:prevention & control / Q000662:veterinary*; D010027:Osteotomy / Q000662:veterinary*; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control / Q000662:veterinary*; D013537:Sutures / Q000662:veterinary*; D013977:Tibia / Q000601:surgery*; D014260:Triclosan / Q000494:pharmacology*
chemical_list: D014260:Triclosan