title: A meta-analysis of the C1420T polymorphism in cytosolic serine hydroxymethyltransferase (SHMT1) among Caucasian colorectal cancer populations.
abstract: OBJECTIVE
  Inconsistency of reported associations between the C1420T polymorphism in the cytosolic serine hydroxymethyltransferase (SHMT1) gene and colorectal cancer (CRC) prompted us to undertake a meta-analysis.
  
  
  METHODS
  We conducted searches of published literature in MEDLINE through PubMed up to April 2012. Individual data on 5,043 cases and 6,311 controls from 15 published case-control studies were evaluated. Meta-analyses were performed on the compiled dataset.
  
  
  RESULTS
  In the overall analysis, association was lacking between the C1420T polymorphism and CRC risk (odds ratio [OR] 0.96-1.04, p = 0.47-0.77), materially unchanged when reanalyzed without the Hardy-Weinberg equilibrium-deviating studies (OR 1.03-1.09, p = 0.22-0.55) or subjected to outlier treatment (OR 0.89-0.99, p = 0.10-0.8). In the ethnic subgroups, Europeans were susceptible (OR 1.11-1.17, p = 0.13-0.48) and Americans, slightly protected (OR 0.86-0.87, p = 0.49-0.61). The increased risk effects, however, became null following outlier treatment (OR 0.95-1.06). Test for interaction between decreased risk associations in the low-folate subgroup (OR 0.60-0.85, p = 0.009-0.03) with the susceptible effects in the high-folate category (OR 1.14-1.22, p = 0.19-0.32) was significant (p interaction = 0.004).
  
  
  CONCLUSIONS
  Overall summary estimates imply no associations but suggest geography-specific effects of the SHMT1 polymorphism that render Europeans susceptible, but not Americans. Folate status appears to show an inverse association of this polymorphism with CRC.
authors: Center for Research and Development, Angeles University Foundation, Angeles City 2009, Philippines.
authors: Noel
authors: N
authors: Pabalan
authors: Hamdi
authors: H
authors: Jarjanazi
authors: Hilmi
authors: H
authors: Ozcelik
mesh_terms: D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D003600:Cytosol / Q000201:enzymology*; D005492:Folic Acid / Q000378:metabolism; D012696:Glycine Hydroxymethyltransferase / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D044465:White People / Q000235:genetics*
chemical_list: D005492:Folic Acid; D012696:Glycine Hydroxymethyltransferase; C520541:SHMT protein, human