title: Controlled assembly and release of retinoic acid based on the layer-by-layer method.
abstract: All-trans retinoic acid (RA) has been proved to play important roles in regulating cell growth in various types of cells. Yet most experiments were performed by adding RA in solution previously. In this Article, we focus on the incorporation of RA, as a negatively charged moiety, into layered polyelectrolyte films on surfaces by means of layer-by-layer (LbL) deposition, followed by adding of capping layers to regulate the release of RA from the films. The incorporated RA was designed to release over 5 days in buffer solution. The assembly and release of RA were verified by UV and QCM results. The controlled release of RA from multilayer films can serve as a model system to study the influence of small molecules on cell growth.
authors: Physikalisches Institut and Center for Nanotechnology, Universität Münster, 48149 Münster, Germany.
authors: Yueyue
authors: Y
authors: Chen
authors: Guanghong
authors: G
authors: Zeng
authors: Fei
authors: F
authors: Pan
authors: Junbo
authors: J
authors: Wang
authors: Lifeng
authors: L
authors: Chi
mesh_terms: D016475:3T3 Cells; D000818:Animals; D049109:Cell Proliferation; D002478:Cells, Cultured; D004573:Electrolytes / Q000138:chemical synthesis / Q000737:chemistry; D051379:Mice; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties; D014212:Tretinoin / Q000737:chemistry*
chemical_list: D004573:Electrolytes; D011108:Polymers; D014212:Tretinoin