title: Significant pathways detection in osteoporosis based on the bibliometric network.
abstract: BACKGROUND
  Osteoporosis is a significant public health issue worldwide. The underlying mechanism of osteoporosis is an imbalance between bone resorption and bone formation. However, the exact pathology is still unclear, and more related genes are on demand.
  
  
  OBJECTIVE
  Here, we aim to identify the differentially expressed genes in osteoporosis patients and control.
  
  
  METHODS
  Biblio-MetReS, a tool to reconstruct gene and protein networks from automated literature analysis, was used for identifying potential interactions among target genes. Relevant signaling pathways were also identified through pathway enrichment analysis.
  
  
  RESULTS
  Our results showed that 56 differentially expressed genes were identified. Of them, STAT1, CXCL10, SOCS3, ADM, THBS1, SOD2, and ERG2 have been demonstrated involving in osteoporosis. Further, a bibliometric network was constructed between DEGs and other genes through the Biblio-MetReS.
  
  
  CONCLUSIONS
  The results showed that STAT1 could interact with CXCL10 through Toll-like receptor signaling pathway and Chemokine signaling pathway. STAT1 interacted with SOCS3 through JAK/STAT pathway.
authors: Department of Orthopaedic Surgery, Jinling Hospital, Nanjing, China.
authors: G J
authors: GJ
authors: Sun
authors: T
authors: T
authors: Guo
authors: Y
authors: Y
authors: Chen
authors: B
authors: B
authors: Xu
authors: J H
authors: JH
authors: Guo
authors: J N
authors: JN
authors: Zhao
mesh_terms: D015706:Bibliometrics; D054357:Chemokine CXCL10 / Q000502:physiology; D051767:Early Growth Response Protein 2 / Q000502:physiology; D053263:Gene Regulatory Networks; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D010024:Osteoporosis / Q000209:etiology / Q000235:genetics*; D050794:STAT1 Transcription Factor / Q000502:physiology; D015398:Signal Transduction; D013482:Superoxide Dismutase / Q000502:physiology; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000502:physiology; D000099156:Superoxide Dismutase 2
chemical_list: D054357:Chemokine CXCL10; D051767:Early Growth Response Protein 2; D050794:STAT1 Transcription Factor; D013482:Superoxide Dismutase; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D000099156:Superoxide Dismutase 2; C114753:CXCL10 protein, human; C497326:EGR2 protein, human; C106644:SOCS3 protein, human; C494079:STAT1 protein, human