title: Ovarian mass, pleural effusion, and ascites: revisiting Meigs syndrome.
abstract: The triad of pleural effusion, ascites, and benign ovarian fibroma is rare. Often, the ovarian mass is accompanied by elevated cancer antigen-125, both in serum and in pleural and peritoneal fluid. When benign ovarian fibroma is associated with ascites and/or pleural effusion it is termed Meigs syndrome. Meigs syndrome, however, is a diagnosis of exclusion only after ovarian carcinoma is ruled out. The presentation of symptoms and radiographic findings mimics that of metastatic ovarian cancer, creating a significant clinical challenge. We report a case of a patient with recurrent pleural effusions and an ovarian mass, with the outside hospital pleural fluid cytology report describing ovarian cancer. Although initially suspected to have metastatic ovarian cancer, subsequent workup of the patient's pleural and peritoneal fluid revealed no carcinoma. Surgical biopsy of the ovarian mass showed the presence of a benign tumor (fibroma). Postovarian mass resection, the patient showed resolution of pleural and peritoneal effusions. We describe our case in detail and review the literature on Meigs syndrome.
authors: Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Diego, CA 92103-8380, USA.
authors: David
authors: D
authors: Riker
authors: Daniel
authors: D
authors: Goba
mesh_terms: D001201:Ascites / Q000150:complications* / Q000000981:diagnostic imaging; D018394:CA-125 Antigen / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000175:diagnosis*; D006801:Humans; D008539:Meigs Syndrome / Q000175:diagnosis; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis; D010996:Pleural Effusion / Q000150:complications*; D014057:Tomography, X-Ray Computed
chemical_list: D018394:CA-125 Antigen