title: Combined influence of information load and opioid peptide opilong on hemostasis and fibrinolysis in rats.
abstract: Preliminary administration of opioid peptide opilong accelerated information perception, but at the same time caused neurotic disorders in rats exposed to information load during training. Under these conditions, suppression of fibrinolysis and hypercoagulation (signs of prethrombosis confirmed by functional thrombin challenge) were detected in the blood. Histochemical analysis of tissues, depots of fibrinolytic enzymes of the anticoagulation system, revealed inadequate weakened tissue response to thrombin in opilong-treated rats in comparison with the control.
authors: Department of Human and Animal Physiology, Faculty of Biology, M. V. Lomonosov Moscow State University, Russia.
authors: L V
authors: LV
authors: Podorolskaya
authors: T N
authors: TN
authors: Serebryakova
authors: K A
authors: KA
authors: Nikolskaya
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D005342:Fibrinolysis / Q000187:drug effects*; D006487:Hemostasis / Q000187:drug effects*; D018847:Opioid Peptides / Q000494:pharmacology*; D010465:Perception / Q000187:drug effects*; D051381:Rats; D013315:Stress, Psychological; D013647:Task Performance and Analysis; D013917:Thrombin / Q000494:pharmacology
chemical_list: D000701:Analgesics, Opioid; D018847:Opioid Peptides; C030058:dermorphin; D013917:Thrombin