title: Unripe Musa sapientum peel in the healing of surgical wounds in rats.
abstract: OBJECTIVE
  To assess the effects of unripe Musa sapientum peel on the healing of surgical wounds in rats.
  
  
  METHODS
  One hundred and twenty Wistar rats were divided into two treatment groups of 60 animals each: the control group (gel without the active ingredient) and experimental group (4% Musa sapientum peel gel). A 4 x 4 cm surgical wound was created on the back of each animal. The wound was cleaned daily with 0.9% saline, treated with 4% gel or natrosol gel (control), and covered with gauze. Animals from both groups were sacrificed after seven, 14 and 21 days of treatment; the tissue from the wound site was removed together with a margin of normal skin for histological analysis.
  
  
  RESULTS
  No significant differences in wound contraction rates (p=0.982) were found between time points (seven, 14 and 21 days of treatment) in both groups. However, a significantly higher wound contraction rate was observed in the control group on day 21 compared with the experimental group (p=0.029). There were no significant differences in histomorphological features between groups. The experimental group showed an increased number of polymorphonuclear cells on day 7, with a significant reduction on day 21 (p=0.026).
  
  
  CONCLUSIONS
  The use of 4% unripe Musa sapientum peel gel on surgical wounds in rats resulted in an increased number of polymorphonuclear cells on day 7, reduced wound contraction, reduced vascular proliferation and increased concentration of collagen fibers on day 21.
authors: Postgraduate Program in Plastic Surgery, UNIFESP, Sao Paulo, Brazil.
authors: Dênia Amélia Novato Castelli Von
authors: DA
authors: Atzingen
authors: Alfredo
authors: A
authors: Gragnani
authors: Daniela Francescato
authors: DF
authors: Veiga
authors: Luis Eduardo Felipe
authors: LE
authors: Abla
authors: Lorraine Lorene Felix
authors: LL
authors: Cardoso
authors: Thiago
authors: T
authors: Ricardo
authors: Adriana Rodrigues dos Anjos
authors: AR
authors: Mendonça
authors: Lydia Masako
authors: LM
authors: Ferreira
mesh_terms: D000818:Animals; D001706:Biopsy; D003094:Collagen / Q000032:analysis; D005782:Gels / Q000627:therapeutic use*; D008297:Male; D028521:Musa; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D005782:Gels; D010936:Plant Extracts; D003094:Collagen