title: Chemical constituents of Caesalpinia decapetala (Roth) Alston.
abstract: The current study targets the chemical constituents of Caesalpinia decapetala (Roth) Alston and investigates the bioactivities of the isolated compounds. Fourteen known compounds were isolated using column chromatography, and structural identification was performed by physical and spectral analyses. The biological activities of the compounds were also evaluated by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2,2-diphenlyl-1-picrylhydrazyl (DPPH) assays. Emodin (6), baicalein (9), and apigenin (12) displayed antitumor activities against the MGC-803 cell line, while quercetin (2), rutin (5), baicalein (9), and epicatechin (13) showed stronger DPPH scavenging activities compared with ascorbic acid. Andrographolide (1), quercetin (2), bergenin (4), rutin (5), emodin (6), betulin (7), baicalein (9), polydatin (10), salicin (11), and apigenin (12), were obtained from C. decapetala (Roth) Alston for the first time.
authors: Research and Development Center for Fine Chemicals, State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China. gzuedit@yahoo.com
authors: Xiao-Hua
authors: XH
authors: Wei
authors: Sheng-Jie
authors: SJ
authors: Yang
authors: Na
authors: N
authors: Liang
authors: De-Yu
authors: DY
authors: Hu
authors: Lin-Hong
authors: LH
authors: Jin
authors: Wei
authors: W
authors: Xue
authors: Song
authors: S
authors: Yang
mesh_terms: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001205:Ascorbic Acid / Q000737:chemistry; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001592:Benzyl Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D029911:Caesalpinia / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004642:Emodin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000094062:Betulinic Acid
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D001205:Ascorbic Acid; D001578:Benzopyrans; D001592:Benzyl Alcohols; D001713:Biphenyl Compounds; D004642:Emodin; D005419:Flavonoids; D016166:Free Radical Scavengers; D005609:Free Radicals; D005960:Glucosides; D010851:Picrates; D010936:Plant Extracts; D013267:Stilbenes; D014315:Triterpenes; C005696:salicin; C002503:betulin; D000094062:Betulinic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl; C006741:bergenin; C058229:polydatin