title: Neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene associated with treatment response to mood stabilizers in patients with bipolar I disorder.
abstract: There is increasing evidence supporting the relationship between bipolar disorder (BP) and neurotrophin. The present study investigated the relationship between neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene polymorphisms and bipolar I disorder (BP I) susceptibility and treatment response to mood stabilizers (lithium or valproate). Two-hundred eighty-four patients who met the DSM-IV criteria for BP I and 295 matched healthy controls were enrolled into this study. TaqMan® SNP genotyping assays were applied to genotype three NTRK2 gene polymorphisms (rs2769605, rs1565445, rs1387923). Our study showed a significant allelic association between NTRK2 gene polymorphism rs2769605 and treatment response to mood stabilizers in BP I patients (t = -2.53, P = 0.01). However, no significant association between NTRK2 gene polymorphisms and BP I susceptibility was observed after correcting for multiple comparisons. The results suggest that the NTRK2 gene polymorphism likely plays an essential role in treatment response to mood stabilizers in Han Chinese BP I patients.
authors: Department of Psychiatry, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai 200030, People's Republic of China. wzwhk@163.com
authors: Zuowei
authors: Z
authors: Wang
authors: Jinbo
authors: J
authors: Fan
authors: Keming
authors: K
authors: Gao
authors: Zezhi
authors: Z
authors: Li
authors: Zhenghui
authors: Z
authors: Yi
authors: Lingxiao
authors: L
authors: Wang
authors: Jia
authors: J
authors: Huang
authors: Chengmei
authors: C
authors: Yuan
authors: Wu
authors: W
authors: Hong
authors: Shunying
authors: S
authors: Yu
authors: Yiru
authors: Y
authors: Fang
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D020813:Receptor, trkB / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D018692:Antimanic Agents; D020813:Receptor, trkB