title: Effect of palonosetron on postanesthetic shivering after propofol-remifentanil total intravenous anesthesia.
abstract: OBJECTIVE
  The authors conducted a prospective, randomized, double-blind study to evaluate the anti-shivering efficacy of palonosetron for patients after gynecological laparoscopy under total intravenous propofol-remifentanil anesthesia.
  
  
  METHODS
  Sixty female patients were randomly assigned to one of two groups and administered palonosetron 0.075 mg (palonosetron group, n = 30) or the same volume of normal saline (control group, n = 30) immediately after anesthesia induction. Anesthesia was induced and maintained with propofol and remifentanil, using a target-controlled infusion device. Esophageal and index finger temperatures were measured immediately after anesthesia induction (baseline) and at 15-min intervals until the end of the surgery. Postanesthetic shivering and side effects were assessed in a postanesthetic care unit.
  
  
  RESULTS
  Incidence of shivering was comparable in the control and palonosetron groups (10/30 vs. 8/30, respectively, P = 0.779). No significant intergroup differences were observed between esophageal and index finger temperatures. Compared with baseline values, esophageal temperatures decreased immediately after pneumoperitoneum in the control group and from 30 min after pneumoperitoneum in the palonosetron group.
  
  
  CONCLUSIONS
  Use of palonosetron (0.075 mg) did not reduce the incidence of postanesthetic shivering after gynecological laparoscopy under propofol-remifentanil anesthesia. Further study including other 5-HT3 antagonists or male patients would elucidate the effect of palonosetron on shivering after propofol-remifentanil anesthesia.
authors: Department of Anesthesiology and Pain Medicine, Gachon University, Gil Medical Center, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Republic of Korea.
authors: Youn Yi
authors: YY
authors: Jo
authors: Hyun Jeong
authors: HJ
authors: Kwak
authors: Mi Geum
authors: MG
authors: Lee
authors: Oh Kyung
authors: OK
authors: Lim
mesh_terms: D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous / Q000009:adverse effects* / Q000379:methods; D001831:Body Temperature / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000008:administration & dosage*; D010535:Laparoscopy / Q000379:methods; D008875:Middle Aged; D000077924:Palonosetron; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects*; D011183:Postoperative Complications / Q000139:chemically induced; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies; D011812:Quinuclidines / Q000008:administration & dosage*; D000077208:Remifentanil; D012768:Shivering / Q000187:drug effects*
chemical_list: D007546:Isoquinolines; D010880:Piperidines; D011812:Quinuclidines; D000077924:Palonosetron; D000077208:Remifentanil; D015742:Propofol