title: Outcome of screening endoscopy in common variable immunodeficiency disorder and X-linked agammaglobulinemia.
abstract: Gastrointestinal symptoms are common in patients with common variable immunodeficiency disorders (CVID) and less frequent in X-linked agammaglobulinemia (XLA) although the exact prevalence is not well established. In this study, endoscopic screening was performed in 30 patients with CVID and four patients with XLA. Endoscopic and/or histological abnormalities were detected in 25 of 30 patients with CVID (83 %), regardless of symptoms, and in nine of these patients the results prompted medical treatment. Helicobacter pylori-associated gastritis, adenomatous polyps, and lymphoid hyperplasia were most frequently encountered; no malignancies were detected. Adenomatous polyps were found in two of the four patients with XLA at a relative young age. In conclusion, gastrointestinal pathology is frequent in patients with CVID regardless of symptoms. Patients with XLA seem to be at risk for colorectal adenomas at a young age.
authors: Department of Internal Medicine and Infectious Diseases, University Medical Centre of Utrecht, The Netherlands. L.J.Maarschalk-Ellerbroek@umcutrecht.nl
authors: L J
authors: LJ
authors: Maarschalk-Ellerbroek
authors: B
authors: B
authors: Oldenburg
authors: I M H
authors: IM
authors: Mombers
authors: A I M
authors: AI
authors: Hoepelman
authors: L A A
authors: LA
authors: Brosens
authors: G J A
authors: GJ
authors: Offerhaus
authors: P M
authors: PM
authors: Ellerbroek
mesh_terms: D018256:Adenomatous Polyps / Q000150:complications* / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications*; D000368:Aged; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000150:complications* / Q000175:diagnosis; D017074:Common Variable Immunodeficiency / Q000150:complications*; D003430:Cross-Sectional Studies; D005260:Female; D005756:Gastritis / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D005773:Gastroscopy; D040181:Genetic Diseases, X-Linked / Q000150:complications*; D016481:Helicobacter Infections / Q000175:diagnosis; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D019310:Pseudolymphoma / Q000150:complications / Q000175:diagnosis; D055815:Young Adult