title: Residual thrombosis after a first episode of proximal deep venous thrombosis.
abstract: The aim of this study was to analyse the normalization rate of compression ultrasonography after a first episode of proximal deep venous thrombosis (DVT). Patients underwent compressive ultrasound (C-US) examinations during the 3-6 months following the first proximal DVT episode. Normalization rate of compressive ultrasound (C-US) during the follow-up period was 26.4% [95% confidence interval, 16.3-37.3]. Allelic variation in factor XIII gene (Val34Leu) significantly affected the improvement of popliteal residual thrombi (P = 0.019). We also observed a significant negative correlation between D-dimer levels at 3 months and improvement of popliteal residual thrombi (P = 0.016). There was a significant positive correlation between baseline lumen diameter of the femoral thrombi and IL-8 cytokine (P = 0.015). A significant difference was also found between 1 month-tumor necrosis factor (TNF)-α levels and improvement of residual thrombi (P = 0.047). Our results show that normalization after a standard period of anticoagulation is not frequent and procoagulant and inflammatory biomarkers and also some genetic variations might be related to the resolution of thrombosis.
authors: Institute of Biomedicine, University Hospital Virgen del Rocío, CIBERES, Seville, Spain.
authors: Ana
authors: A
authors: Montes-Worboys
authors: Elena
authors: E
authors: Arellano
authors: Teresa
authors: T
authors: Elías
authors: José
authors: J
authors: León
authors: José-Antonio
authors: JA
authors: Rodriguez-Portal
authors: Remedios
authors: R
authors: Otero
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000925:Anticoagulants / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D005176:Factor XIII / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D011152:Popliteal Vein / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology*; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*
chemical_list: D000925:Anticoagulants; D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; C036309:fibrin fragment D; D005176:Factor XIII