title: Successful allogeneic hematopoietic stem cell transplantation in a young patient with Richter syndrome presenting with chronic lymphocytic leukemia and diffuse large B-cell lymphoma with different cell origins.
abstract: A 32-year-old woman was referred to our hospital due to systemic lymphadenopathy. The patient's peripheral blood showed expansion of CD5+CD20+ CD38+ CD23- mature lymphocytes. However, the axillary lymph nodes were infiltrated by both CD23+ large lymphocytes and CD23- small lymphocytes. Because the pattern of the rearranged immunoglobulin heavy chain gene was different between the peripheral blood and lymph node samples in a Southern blot analysis, the patient was diagnosed with Richter syndrome, in which diffuse large B-cell lymphoma develops from a clone distinct from B-cell chronic lymphocytic leukemia. After undergoing rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) therapy, the patient was successfully treated with allogeneic hematopoietic transplantation, and no relapse was observed for three years.
authors: Department of Hematology and Rheumatology, Kinki University Faculty of Medicine, Japan. rai@med.kindai.ac.jp
authors: Shinya
authors: S
authors: Rai
authors: Mitsuhiro
authors: M
authors: Matsuda
authors: Nozomi
authors: N
authors: Yamairi
authors: Go
authors: G
authors: Eguchi
authors: Takayuki
authors: T
authors: Iwanaga
authors: Yasuyoshi
authors: Y
authors: Morita
authors: Hirokazu
authors: H
authors: Tanaka
authors: Yoichi
authors: Y
authors: Tatsumi
authors: Takashi
authors: T
authors: Ashida
authors: Itaru
authors: I
authors: Matsumura
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D014184:Transplantation, Homologous; D016896:Treatment Outcome