title: Enteric oxalate nephropathy in the renal allograft: an underrecognized complication of bariatric surgery.
abstract: Enteric hyperoxalosis is a recognized complication of bariatric surgery, with consequent oxalate nephropathy leading to chronic kidney disease and occasionally end-stage renal failure. In patients with prior gastrointestinal bypass surgery, renal allografts are also at risk of oxalate nephropathy. Further, transplant recipients may be exposed to additional causes of hyperoxalosis. We report two cases of renal allograft oxalate nephropathy in patients with remote histories of bariatric surgery. Conservative management led to improvement of graft function in one patient, while the other patient returned to dialysis. Interpretation of serologic, urine and biopsy studies is complicated by oxalate accumulation in chronic renal failure, and heightened excretion in the early posttransplant period. A high index of suspicion and careful clinicopathologic correlation on the part of transplant nephrologists and renal pathologists are required to recognize and treat allograft oxalate nephropathy. As the incidence of obesity and pretransplant bariatric surgery increases in the transplant population, allograft oxalate nephropathy is likely to be an increasing cause of allograft dysfunction.
authors: Department of Pathology, Oregon Health & Science University, Portland, OR, USA. troxellm@ohsu.edu
authors: M L
authors: ML
authors: Troxell
authors: D C
authors: DC
authors: Houghton
authors: M
authors: M
authors: Hawkey
authors: T D
authors: TD
authors: Batiuk
authors: W M
authors: WM
authors: Bennett
mesh_terms: D000368:Aged; D050110:Bariatric Surgery; D001706:Biopsy; D002129:Calcium Oxalate / Q000378:metabolism*; D003460:Crystallization; D005260:Female; D041981:Gastrointestinal Tract / Q000378:metabolism; D006084:Graft Rejection; D006801:Humans; D006959:Hyperoxaluria / Q000150:complications / Q000628:therapy*; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D009398:Nephrology; D009765:Obesity / Q000150:complications / Q000601:surgery; D014184:Transplantation, Homologous
chemical_list: D002129:Calcium Oxalate