title: Organic solvent vapor effects on phase transition of α and β tegafur upon grinding with solvent additives.
abstract: Solvent effects on α tegafur (5-fluoro-1-(tetrahydro-2-furyl)uracil) phase transition to β tegafur during grinding with solvent additive, as well as phase transition in samples exposed to 95% relative solvent vapor pressure has been studied in this research. Samples containing 0.5% and 0.1% of β tegafur in α and β tegafur mixture, as well as samples of pure α tegafur were ground with different solvent additives, and conversion degrees depending on the solvent were determined using PXRD method. Samples with α and β tegafur weight fraction of 1:1 were exposed to 95% relative solvent vapor pressure, and phase transition rates were determined. Solubility of α tegafur, solvent sorption and desorption behavior on α and β tegafur have been examined. It was found that the conversion degree of α tegafur to β tegafur mainly depends on solubility of α tegafur in the relevant solvent, and the conversion degree to β tegafur is higher in such solvents, where solubility of α tegafur is higher. The samples ground in a ball mill with solvent additive had a trend of phase transition dynamics from α tegafur to β tegafur similar to the samples exposed to 95% relative solvent vapor pressure.
authors: University of Latvia, Faculty of Chemistry, Kr. Valdemara iela 48, Riga LV-1013, Latvia. raitis.bobrovs@gmail.com
authors: Raitis
authors: R
authors: Bobrovs
authors: Olga
authors: O
authors: Saveļjeva
authors: Agnese
authors: A
authors: Kapace
authors: Zane
authors: Z
authors: Plauka
authors: Andris
authors: A
authors: Actiņš
mesh_terms: D000327:Adsorption; D000438:Alcohols / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D007536:Isomerism; D044367:Phase Transition; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D005641:Tegafur / Q000737:chemistry*; D013816:Thermodynamics; D055548:Vapor Pressure; D014835:Volatilization; D014961:X-Ray Diffraction
chemical_list: D000438:Alcohols; D012997:Solvents; D005641:Tegafur