title: Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients.
abstract: Spontaneous clearance of hepatitis B surface antigen (HBsAg) in chronic hepatitis B (CHB) patients usually indicates a remission of hepatitis activity and a favorable outcome. Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection. However, little is known about the impact of these 2 SNPs on spontaneous HBsAg clearance in CHB patients. In this case-control study, a total of 100 male HBeAg-negative chronic HBV carriers who cleared HBsAg spontaneously (case group) and 100 age-matched HBeAg-negative male patients with persistent HBsAg positivity (control group) were enrolled. We investigated the relationship between these 2 SNPs and HBsAg clearance. There was a higher frequency of rs9277535 non-GG genotype in the case group (57% vs. 42%). Patients with rs9277535 non-GG genotype had a higher chance to clear HBsAg [Odds ratio (OR): 1.83, 95% confidence interval (CI): 1.04∼3.21, P = 0.034]. Compared to GG haplotype of rs3077 and rs9277535, GA haplotype had a higher chance of achieving spontaneous HBsAg loss (OR: 2.17, 95% CI: 1.14∼4.16, P = 0.030). In conclusion, rs9277535 non-GG genotype is associated with a higher likelihood of spontaneous HBsAg seroclearance in CHB patients.
authors: Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan.
authors: Huei-Ru
authors: HR
authors: Cheng
authors: Chun-Jen
authors: CJ
authors: Liu
authors: Tai-Chung
authors: TC
authors: Tseng
authors: Tung-Hung
authors: TH
authors: Su
authors: Hwai-I
authors: HI
authors: Yang
authors: Chien-Jen
authors: CJ
authors: Chen
authors: Jia-Horng
authors: JH
authors: Kao
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D005787:Gene Frequency; D005838:Genotype; D059867:HLA-DP alpha-Chains / Q000235:genetics / Q000276:immunology; D059868:HLA-DP beta-Chains / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000235:genetics / Q000276:immunology* / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics / Q000276:immunology*
chemical_list: D059867:HLA-DP alpha-Chains; D059868:HLA-DP beta-Chains; C071172:HLA-DPA1 antigen; C071170:HLA-DPB1 antigen; D006514:Hepatitis B Surface Antigens