title: A single mesoporous ZnO/Chitosan hybrid nanostructure for a novel free nanoprobe type biosensor.
abstract: A novel method of fabricating a free probe type nanoscale biosensor is first demonstrated. A free probe type biosensor based on a single one-dimensional (1D) mesoporous ZnO/Chitosan inorganic-organic hybrid nanostructure is constructed. The as-prepared biosensor exhibited excellent biosensing performance and was stable in solution due to its inorganic-organic hybrid structure. The special mesoporous nanostructure with protuberances favors enzymes loading and enhances electrical communication efficiency. The feasibility of employing a single 1D nanostructure as a separate free nanoprobe for biosensing is demonstrated. This kind of free probe type biosensor will not only provides a new tool for micro-targets detection in microcell and enzymatic studies, but also has the potential to be inserted into single cell or other microorganism for biological studies.
authors: Department of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China.
authors: Minggang
authors: M
authors: Zhao
authors: Jingyun
authors: J
authors: Huang
authors: Yu
authors: Y
authors: Zhou
authors: Qi
authors: Q
authors: Chen
authors: Xinhua
authors: X
authors: Pan
authors: Haiping
authors: H
authors: He
authors: Zhizhen
authors: Z
authors: Ye
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D048271:Chitosan / Q000737:chemistry*; D003217:Conductometry / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D015336:Molecular Probe Techniques / Q000295:instrumentation*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D048271:Chitosan; D015034:Zinc Oxide