title: Genome-wide chromatin state transitions associated with developmental and environmental cues.
abstract: Differences in chromatin organization are key to the multiplicity of cell states that arise from a single genetic background, yet the landscapes of in vivo tissues remain largely uncharted. Here, we mapped chromatin genome-wide in a large and diverse collection of human tissues and stem cells. The maps yield unprecedented annotations of functional genomic elements and their regulation across developmental stages, lineages, and cellular environments. They also reveal global features of the epigenome, related to nuclear architecture, that also vary across cellular phenotypes. Specifically, developmental specification is accompanied by progressive chromatin restriction as the default state transitions from dynamic remodeling to generalized compaction. Exposure to serum in vitro triggers a distinct transition that involves de novo establishment of domains with features of constitutive heterochromatin. We describe how these global chromatin state transitions relate to chromosome and nuclear architecture, and discuss their implications for lineage fidelity, cellular senescence, and reprogramming.
authors: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
authors: Jiang
authors: J
authors: Zhu
authors: Mazhar
authors: M
authors: Adli
authors: James Y
authors: JY
authors: Zou
authors: Griet
authors: G
authors: Verstappen
authors: Michael
authors: M
authors: Coyne
authors: Xiaolan
authors: X
authors: Zhang
authors: Timothy
authors: T
authors: Durham
authors: Mohammad
authors: M
authors: Miri
authors: Vikram
authors: V
authors: Deshpande
authors: Philip L
authors: PL
authors: De Jager
authors: David A
authors: DA
authors: Bennett
authors: Joseph A
authors: JA
authors: Houmard
authors: Deborah M
authors: DM
authors: Muoio
authors: Tamer T
authors: TT
authors: Onder
authors: Ray
authors: R
authors: Camahort
authors: Chad A
authors: CA
authors: Cowan
authors: Alexander
authors: A
authors: Meissner
authors: Charles B
authors: CB
authors: Epstein
authors: Noam
authors: N
authors: Shoresh
authors: Bradley E
authors: BE
authors: Bernstein
mesh_terms: D002467:Cell Nucleus; D016922:Cellular Senescence; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D053595:Embryonic Stem Cells / Q000378:metabolism; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D059647:Gene-Environment Interaction; D055106:Genome-Wide Association Study; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism; D009928:Organ Specificity
chemical_list: D002843:Chromatin