title: Endogenous CETP activity as a predictor of cardiovascular risk: determination of the optimal range.
abstract: OBJECTIVE
  To identify key determinants of plasma endogenous CETP activity and threshold value of plasma CETP activity associated with high cardiovascular risk.
  
  
  METHODS
  Endogenous plasma CETP activity was measured in a total of 1403 individuals.
  
  
  RESULTS
  Multivariate analysis revealed that 23.5% of endogenous CETP activity variability was explained by plasma LDL-C (12.0%), HDL-C (6.4%) and TG (4.4%) whereas sex and BMI accounted together for only 0.7% of its variability. Scoring patients for cardiovascular risk on the basis of their plasma lipid levels (TC, TG, LDL-C and HDL-C), revealed that patients with high cardiovascular risk (score ≥3) displayed a mean endogenous plasma CETP activity above 34%.
  
  
  CONCLUSIONS
  Plasma CETP activity represents a potent indicator of cardiovascular risk in patients with metabolic disorders since it integrates major independent risk factors.
authors: INSERM UMRS939, Hôpital de la Pitié, Paris, France.
authors: Elise F
authors: EF
authors: Villard
authors: Marie-Christine
authors: MC
authors: Federspiel
authors: Corinne
authors: C
authors: Cherfils
authors: Valérie
authors: V
authors: Fesel-Fouquier
authors: Eric
authors: E
authors: Bruckert
authors: Karine
authors: K
authors: Clement
authors: Dominique
authors: D
authors: Bonnefont-Rousselot
authors: Wilfried
authors: W
authors: Le Goff
authors: Randa
authors: R
authors: Bittar
authors: Philippe
authors: P
authors: Couvert
authors: Maryse
authors: M
authors: Guerin
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology*; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides