title: A thermoplastic elastomer patch matrix for traditional Chinese medicine: design and evaluation.
abstract: OBJECTIVE
  To design and evaluate a novel pressure sensitive adhesive (PSA) patch containing traditional Chinese medicine (TCM) using styrene-isoprene-styrene (SIS) copolymer.
  
  
  METHODS
  A mixture D-optimal design with ternary response surface diagram was employed in the optimization process. The proportions of SIS copolymer, tackifying resin and plasticizer were selected as the independent variables while tack force, peel strength of the patch and skin penetrability of methyl salicylate were selected as the dependent variables. The optimized patch was then evaluated including in vivo absorption, pharmacological activities and skin irritation, by comparing with a commercial patch based on natural rubber.
  
  
  RESULTS
  The optimized patch, which comprised 30.0% SIS copolymer, 26.6% tackifying resin and 43.4% plasticizer, was superior to commercial patch in skin permeation, pharmacological activities and skin biocompatibility.
  
  
  CONCLUSIONS
  SIS copolymer was a suitable substitute to natural rubber in producing patches containing TCM formula.
authors: School of Pharmacy, East China University of Science and Technology , Shanghai , China.
authors: Chengxiao
authors: C
authors: Wang
authors: Jianfang
authors: J
authors: Ma
authors: Ran
authors: R
authors: Liu
authors: Wei
authors: W
authors: Han
authors: Xiuzhen
authors: X
authors: Tang
mesh_terms: D000818:Animals; D002070:Butadienes / Q000008:administration & dosage / Q000737:chemistry*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D020724:Elastomers / Q000008:administration & dosage / Q000737:chemistry*; D006168:Guinea Pigs; D045782:Hemiterpenes / Q000008:administration & dosage / Q000737:chemistry*; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods; D051379:Mice; D008812:Mice, Hairless; D009924:Organ Culture Techniques; D010420:Pentanes / Q000008:administration & dosage / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology; D020058:Styrene / Q000008:administration & dosage / Q000737:chemistry*; D057968:Transdermal Patch
chemical_list: D002070:Butadienes; D004365:Drugs, Chinese Herbal; D020724:Elastomers; D045782:Hemiterpenes; D010420:Pentanes; C005059:isoprene; D020058:Styrene