title: [The role of neurotrophic factors in regeneration of the nervous system].
abstract: Neurotrophic factors regulate survival, development, and function of nervous tissue. They act via two different classes of receptors and activation of various signaling pathways in the target cells. Illumination of their physiological role in the maintenance of central nervous system homeostasis as well as regeneration of damaged tissue have ignited expectations to heal neurodegenerative diseases, including amyotrophic late-ral sclerosis and Parkinson disease. Advances in pharmaco-therapy, gene therapy, and stem cell biology have enabled development of novel therapies with application of regenerating cell transplantation. In the foreseeable future, it may lead to the establishment of safe and effective ways of treatment of these severe and currently incurable diseases.
authors: Zakład Patologii Ogólnej Katedry Fizjopatologii, Pomorski Uniwersytet Medyczny, Szczecin. machalin@pum.edu.pl
authors: Bogusław
authors: B
authors: Machaliński
authors: Piotr
authors: P
authors: Lażewski-Banaszak
authors: Elżbieta
authors: E
authors: Dąbkowska
authors: Edyta
authors: E
authors: Paczkowska
authors: Monika
authors: M
authors: Gołąb-Janowska
authors: Przemysław
authors: P
authors: Nowacki
mesh_terms: D002493:Central Nervous System Diseases / Q000503:physiopathology / Q000628:therapy*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy; D044968:Regenerative Medicine / Q000379:methods; D033581:Stem Cell Transplantation / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods
chemical_list: D009414:Nerve Growth Factors