title: Antimicrobial susceptibility of stenotrophomonas maltophilia isolates from Korea, and the activity of antimicrobial combinations against the isolates.
abstract: The aim of this study was to determine antimicrobial susceptibility of recent clinical Stenotrophomonas maltophilia isolates from Korea, and to compare the activity levels of several combinations of antimicrobials. A total of 206 non-duplicate clinical isolates of S. maltophilia was collected in 2010 from 11 university hospitals. Antimicrobial susceptibility testing was performed using the Clinical Laboratory Standards Institute agar dilution method. In vitro activity of antimicrobial combinations was tested using the checkerboard method. The susceptibility rates to trimethoprim-sulfamethoxazole and minocycline were 96% and 99%, respectively. The susceptibility rate to levofloxacin was 64%. All of four antimicrobial combinations showed synergy against many S. maltophilia isolates. A combination of trimethoprim-sulfamethoxazole plus ticarcillin-clavulanate was most synergistic among the combinations. None of the combinations showed antagonistic activity. Therefore, some of the combinations may be more useful than individual drugs in the treatment of S. maltophilia infection. Further clinical studies are warranted to validate our in vitro test results.
authors: Department of Laboratory Medicine and Research Institute of Antimicrobial Resistance, Yonsei University College of Medicine, Seoul, Korea.
authors: Hae-Sun
authors: HS
authors: Chung
authors: Seong Geun
authors: SG
authors: Hong
authors: Young Ree
authors: YR
authors: Kim
authors: Kyeong Seob
authors: KS
authors: Shin
authors: Dong Hee
authors: DH
authors: Whang
authors: Jee Young
authors: JY
authors: Ahn
authors: Yeon-Joon
authors: YJ
authors: Park
authors: Young
authors: Y
authors: Uh
authors: Chulhun L
authors: CL
authors: Chang
authors: Jong Hee
authors: JH
authors: Shin
authors: Hye Soo
authors: HS
authors: Lee
authors: Kyungwon
authors: K
authors: Lee
authors: Yunsop
authors: Y
authors: Chong
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D006785:Hospitals, University; D006801:Humans; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D056910:Republic of Korea; D020615:Stenotrophomonas maltophilia / Q000187:drug effects* / Q000302:isolation & purification; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D064704:Levofloxacin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D015242:Ofloxacin; D008911:Minocycline
keywords: Combination Drug Therapy; Stenotrophomonas maltophilia; Ticarcillin-Clavulanate; Trimethoprim-Sulfamethoxazole