title: A pilot study of the duodenal-jejunal bypass liner in low body mass index type 2 diabetes.
abstract: BACKGROUND
  The duodenal-jejunal bypass liner (DJBL) is a device that mimics the intestinal portion of gastric bypass surgery and has been shown to improve glucose metabolism rapidly in obese subjects with type 2 diabetes (T2DM).
  
  
  OBJECTIVE
  To assess the safety of the DJBL and to evaluate its potential to affect glycemic control beneficially in subjects with T2DM who were not morbidly obese.
  
  
  METHODS
  Adult men and women with T2DM of ≤ 10 years' duration with hemoglobin A1c (HbA1c) ≥ 7.5% and ≤ 10% and having a body mass index ≥ 26 to ≤ 50 kg/m(2) were enrolled in this prospective, 52-week, single-center, open-label clinical study.
  
  
  METHODS
  Adverse events and changes in body weight, fasting plasma glucose (FPG) levels, and HbA1c levels.
  
  
  RESULTS
  Sixteen of 20 subjects implanted with the DJBL completed the 1-year study (mean body mass index = 30.0 ± 3.6, mean ± SD). Gastrointestinal disorders were reported by 13 subjects, and metabolic or nutritional disorders occurred in 14 subjects. FPG levels dropped from 207 ± 61 mg/dL at baseline to 139 ± 37 mg/dL at 1 week and remained low throughout the study. Mean body weight also declined, but the change in body weight was not significantly associated with change in FPG at 52 weeks. HbA1c declined from 8.7 ± 0.9% at baseline to 7.5 ± 1.6% at week 52.
  
  
  CONCLUSIONS
  The improvements in glycemic status were observed at 1 year in moderately obese subjects with T2DM, suggesting that the DJBL may represent an effective adjuvant to standard medical therapy of T2DM in this population.
authors: Center of Excellence of Metabolic and Bariatric Surgery, Hospital Oswaldo Cruz, Rua Padre Joao Manuel 222 CJ 131, São Paulo-SP, Brasil 04002-020. ricardo.cohen@haoc.com.br
authors: Ricardo Vitor
authors: RV
authors: Cohen
authors: Manoel Galvão
authors: MG
authors: Neto
authors: Jose Luis
authors: JL
authors: Correa
authors: Paulo
authors: P
authors: Sakai
authors: Bruno
authors: B
authors: Martins
authors: Carlos Aurélio
authors: CA
authors: Schiavon
authors: Tarissa
authors: T
authors: Petry
authors: Joao Eduardo
authors: JE
authors: Salles
authors: Cristina
authors: C
authors: Mamedio
authors: Christopher
authors: C
authors: Sorli
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000601:surgery*; D004386:Duodenum / Q000378:metabolism / Q000601:surgery*; D005260:Female; D015390:Gastric Bypass / Q000379:methods*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007583:Jejunum / Q000378:metabolism / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D005947:Glucose