title: Modulation of immunity by antiangiogenic molecules in cancer.
abstract: In the last decades a new class of therapeutic drugs have been developed that block tumor angiogenesis. These antiangiogenic molecules, which target VEGF or VEGFR, PDGFR, and c-kit, can act not only on endothelial cells but also on immune cells. Some antiangiogenic molecules inhibit the development of immunosuppressive mechanisms developed by the tumors to escape the immune system (such as regulatory T cells, myeloid-derived suppressor cells, and immunosuppressive cytokines). These immunomodulatory effects must be characterized in detail to enable a better prescription of these treatments. In this paper we will focus on the impact of anti-angiogenic drugs on immunosuppression and their potential combination with immunotherapeutic strategies. Interestingly, immune parameters or their modulation during treatment could serve as potential biomarkers of response or resistance to anti-angiogenic therapies.
authors: INSERM U970, Paris Cardiovascular Research Center, Université Paris-Descartes, Sorbonne Paris Cité, 56 rue Leblanc, 75015 Paris, France.
authors: Magali
authors: M
authors: Terme
authors: Orianne
authors: O
authors: Colussi
authors: Elie
authors: E
authors: Marcheteau
authors: Corinne
authors: C
authors: Tanchot
authors: Eric
authors: E
authors: Tartour
authors: Julien
authors: J
authors: Taieb
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D006801:Humans; D007109:Immunity / Q000187:drug effects / Q000276:immunology; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy* / Q000276:immunology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000276:immunology
chemical_list: D020533:Angiogenesis Inhibitors; D007155:Immunologic Factors