title: Nano-lipoidal carriers of isotretinoin with anti-aging potential: formulation, characterization and biochemical evaluation.
abstract: BACKGROUND
  Treatment of photoaging includes non-prescription cosmeceuticals and prescription products, retinoids. Isotretinoin, an established anti-acne retinoid, is also reported to delay the aging process. However, the drug is reported to be an irritant on skin.
  
  
  OBJECTIVE
  The present study endeavors to explore the potential of a novel set of biocompatible nano-structured systems of isotretinoin in the treatment of photoaging.
  
  
  METHODS
  Nano-lipoidal carriers (NLCs) of isotretinoin were developed, characterized and investigated in vivo for anti-aging potential in Laca mice vis-à-vis the marketed products of retinoids. The anti-aging efficacy of NLCs was measured in terms of visual and redox-biochemical parameters in ultraviolet (UV)-irradiated mice.
  
  
  RESULTS
  Visual observations revealed that there was no significant change (p < 0.05) w.r.t. erythema, skin sagging and wrinkles in the skin of the animals treated with NLCs formulation compared to the marketed product(s). The malondialdehyde levels were found to be significantly reduced, whereas glutathione levels were increased with the application of NLCs vis-à-vis control and test formulations. The NLCs were able to maintain the normal redox-balance of UV-irradiated skin, and were better tolerated by the animals.
  
  
  CONCLUSIONS
  The study ratifies enhancement in the efficacy of isotretinoin against photoaging and improved skin biocompatibility after its encasement in novel topical dosage forms.
authors: Division of Pharmaceutics, University Institute of Pharmaceutical Sciences, UGC-Centre of Advanced Study, Panjab University, Chandigarh 160-014, India.
authors: Kaisar
authors: K
authors: Raza
authors: Bhupinder
authors: B
authors: Singh
authors: Nitish
authors: N
authors: Singla
authors: Poonam
authors: P
authors: Negi
authors: Parteek
authors: P
authors: Singal
authors: Om Prakash
authors: OP
authors: Katare
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D004890:Erythema / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D015474:Isotretinoin / Q000008:administration & dosage* / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000008:administration & dosage* / Q000737:chemistry; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry; D010084:Oxidation-Reduction / Q000187:drug effects; D012212:Rheology / Q000379:methods; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D004337:Drug Carriers; D008055:Lipids; D008315:Malondialdehyde; D015474:Isotretinoin; D005978:Glutathione