title: The role of mannose-6-phosphate receptor and autophagy in influencing the outcome of combination therapy.
abstract: Combining two different treatment modalities for targeting malignancies is gaining importance, with preclinical/clinical results indicating higher success rates in eradicating tumors or having longer remission periods. A better understanding of the synergy between the treatments helps in optimizing the dose and time of administration. We found that chemotherapy enhanced the levels of insulin-like growth factor 2 receptor/cation-independent mannose-6-phosphate receptor (IGF2R) on the surface of tumor cells, which leads to better tumor targeting by cytotoxic T cells (CTLs). Early evidence indicates that upregulation of IGF2R involves the autophagy pathway.
authors: H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors: Rupal
authors: R
authors: Ramakrishnan
authors: Dmitry I
authors: DI
authors: Gabrilovich
mesh_terms: D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D045744:Cell Line, Tumor; D004358:Drug Therapy; D053804:Granzymes / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D017527:Receptor, IGF Type 2 / Q000378:metabolism*; D015398:Signal Transduction; D016896:Treatment Outcome
chemical_list: D017527:Receptor, IGF Type 2; D053804:Granzymes
keywords: autophagy; chemotherapy; immunotherapy; mannose-6-phosphate receptor