title: MHC-II ubiquitination.
abstract: Ubiquitinated protein detection is often troublesome since in most cases this modification reduces the half-life of targeted proteins, inducing their degradation. Furthermore, ubiquitination is reversible thanks to the action of highly specific deubiquitinases present in all eukaryotic cells. MHC molecules ubiquitination has been demonstrated to be a key event in the regulation of the potent immunostimulatory properties of activated human dendritic cells.
authors: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France.|Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France.|Centre National de la Recherche Scientifi que (CNRS), UMR7280, Marseille, France.
authors: Aude
authors: A
authors: De Gassart
authors: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France.|Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France.|Centre National de la Recherche Scientifi que (CNRS), UMR7280, Marseille, France.
authors: Francesca
authors: F
authors: De Angelis Rigotti
authors: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France. gatti@ciml.univ-mrs.fr.|Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France. gatti@ciml.univ-mrs.fr.|Centre National de la Recherche Scientifi que (CNRS), UMR7280, Marseille, France. gatti@ciml.univ-mrs.fr.
authors: Evelina
authors: E
authors: Gatti
mesh_terms: D015153:Blotting, Western; D003713:Dendritic Cells / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D006367:HeLa Cells; D000949:Histocompatibility Antigens Class II / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D047468:Immunoprecipitation; D009000:Monocytes / Q000166:cytology; D054875:Ubiquitination
chemical_list: D000949:Histocompatibility Antigens Class II