title: Isolated unilateral tongue oedema: the adverse effect of Angiotensin converting enzyme inhibitors.
abstract: Angiotensin converting enzyme inhibitors (ACEI) are widely used to treat benign hypertension. These drugs are generally well tolerated. Serious side effects such as angio-oedema are very rare. The authors report a 64-year-old Caucasian woman with a history of liver transplant on Mammalian Target Of Rapamycin (mTOR) inhibitor, who attended Emergency department with angio-oedema only on the left side of her tongue. Her airway was patent and she was haemodynamically stable. Trauma was denied. Her physician had 2 days earlier commenced her on Lisinopril for newly diagnosed benign hypertension. Intravenous steroids and anti-histamine were immediately administered. A good response of oedema subsidence was noted. In general, angio-oedema can present in a spectrum of severity. Precipitating factors are often difficult to pre-determine and avoid. Early recognition of risk factors for and diagnosis of angio-oedema can often be life-saving.
authors: University Hospitals Coventry and Warwickshire, Warwick, UK. ed.leung@doctors.org.uk
authors: Edmund
authors: E
authors: Leung
authors: Marcelino Yazbek
authors: MY
authors: Hanna
authors: Nadeem
authors: N
authors: Tehami
authors: James
authors: J
authors: Francombe
mesh_terms: D000799:Angioedema / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017706:Lisinopril / Q000009:adverse effects*; D008875:Middle Aged; D014060:Tongue Diseases / Q000139:chemically induced*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D017706:Lisinopril