title: Use of diagnostics in wound management.
abstract: OBJECTIVE
  Wound healing research has progressed impressively over the past years. New insights into the pathogenesis of different chronic wounds and the study of novel treatment have made wound healing a model disorder and have revealed basic cellular and molecular mechanisms underlying chronic wounds. Although the observation is so obvious and simple, the interpretations by different observers can be quite variable. The interpretations of severity and change in severity by treatment may differ considerably between patient and practitioners.
  
  
  RESULTS
  In this review we provide comprehensive view on different aspects of wound diagnostic, including clinical measurement, new biomarkers in wound pathology, proteases evaluation, and future noninvasive sensor-based devices.
  
  
  CONCLUSIONS
  Wound caregivers are in the unique position of being able to observe the wound changes and describe these with knowledge and strict methodology, but also with the wide range of available wound diagnostic devices. The complexity of severity assessment in wound healing is reflected by the multiple clinical scores available. The best objective methods used to evaluate cutaneous tissue repair should have a high specificity and sensitivity and a low inter and intraobserver variation.
authors: Wound Healing Research Unit, Department of Dermatology, University of Pisa, Pisa, Italy. marco.romanelli@med.unipi.it
authors: Marco
authors: M
authors: Romanelli
authors: Maria
authors: M
authors: Miteva
authors: Paolo
authors: P
authors: Romanelli
authors: Sabrina
authors: S
authors: Barbanera
authors: Valentina
authors: V
authors: Dini
mesh_terms: D015415:Biomarkers; D001706:Biopsy; D002908:Chronic Disease; D004396:Coloring Agents; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008827:Microbiological Phenomena; D018613:Microscopy, Confocal; D010447:Peptide Hydrolases / Q000032:analysis; D012867:Skin / Q000293:injuries*; D012883:Skin Ulcer / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D014945:Wound Healing; D014947:Wounds and Injuries / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy
chemical_list: D015415:Biomarkers; D004396:Coloring Agents; D010447:Peptide Hydrolases