title: Overexpression of c-Met in cervical intraepithelial neoplasia.
abstract: OBJECTIVE
  The purpose of this study is to evaluate the significance of the c-Met / Hepatocyte Growth Factor Receptor (HGFR) expression in cervical intraepithelial neoplasia (CIN).
  
  
  METHODS
  Twenty-one patients from two types of cervical intraepithelial neoplasias (LSIL and HSIL), diagnosed in our clinic were studied with c-Met immunohistochemistry. Of the 21 cases, five were diagnosed as LSIL and 16 as HSIL. Normal cervical mucosas from five patients were studied with c-Met as control cases.
  
  
  RESULTS
  Overexpression of c-Met was found in all five of LSIL specimens. C-Met overexpression was observed in 11 cases of HSIL. No c-Met overexpression was seen in any of the five control cases.
  
  
  CONCLUSIONS
  These results revealed that c-Met oncogene overexpression is an important parameter in cervical early oncogenesis and may have a role in malignant transformation of cervical epithelial cells.
authors: Near East University, Faculty of Medicine, Department of Pathology, Nicosia, Turkish Republic of Northern Cyprus, Turkey. cemcomunoglu@gmail.com
authors: C
authors: C
authors: Comunoğlu
authors: K
authors: K
authors: Boynukalin
authors: M G
authors: MG
authors: Uğur
authors: R
authors: R
authors: Al
authors: G Mocan
authors: GM
authors: Kuzey
authors: C
authors: C
authors: Baykal
mesh_terms: D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019859:Proto-Oncogene Proteins c-met / Q000032:analysis* / Q000502:physiology; D002583:Uterine Cervical Neoplasms / Q000737:chemistry* / Q000209:etiology; D002578:Uterine Cervical Dysplasia / Q000737:chemistry* / Q000209:etiology
chemical_list: D019859:Proto-Oncogene Proteins c-met