title: Sensing of cell death by myeloid C-type lectin receptors.
abstract: Molecules associated with dead or dying cells can be detected by receptors on macrophages and dendritic cells. Signals from these receptors impact myeloid cell function and play a role in determining whether death is silent or proinflammatory, tolerogenic or immunogenic. Prominent among myeloid receptors detecting dead cells are C-type lectin receptors (CLRs). Signals from these receptors variably induce endocytosis of cell corpses, corpse degradation, retrieval of dead cell-associated antigens and/or modulation of immune responses. The sensing of tissue damage by myeloid CLRs complements detection of pathogens in immunity and represents an ancient response aimed at restoring tissue homeostasis.
authors: Department of Vascular Biology and Inflammation, CNIC-Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro 3, E-28029 Madrid, Spain. dsancho@cnic.es
authors: David
authors: D
authors: Sancho
authors: Caetano
authors: C
authors: Reis e Sousa
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D004705:Endocytosis; D006706:Homeostasis; D054884:Host-Pathogen Interactions; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D056747:Immunomodulation; D037181:Lectins, C-Type / Q000276:immunology*; D022423:Myeloid Cells / Q000276:immunology*
chemical_list: D001324:Autoantigens; D037181:Lectins, C-Type