title: Global organization of functional brain connectivity in methamphetamine abusers.
abstract: OBJECTIVE
  This study aimed to determine effects of chronic methamphetamine (MA) abuse on global organization of the functional brain connectivity.
  
  
  METHODS
  Eyes-closed resting-state EEGs of 36 MA abusers and 36 age-matched healthy subjects were recorded using a 32-channel system. The EEGs (1-60 Hz), after removing artifacts, were decomposed into the conventional EEG bands. Using visibility graph similarity (VGS) and coherence methods, the VGS and coherence matrices in each EEG band were constructed. Then the Small-World Network properties, clustering coefficient (C), mean path length (L) and C/L, of the VGS and coherence matrices, were computed in all EEG bands. Then using the Mann-Whitney test and an artificial neural network the differences of C, L and C/L between the two groups were evaluated.
  
  
  RESULTS
  The MA abusers showed higher C, lower L and higher C/L at the gamma band (p-value < 0.005). An accuracy of 82.8% in discriminating the two groups was obtained by the classifier.
  
  
  CONCLUSIONS
  The topology of the functional brain connectivity is disrupted in MA abusers, as depicted by deviation from Small-Worldness in the gamma band.
  
  
  CONCLUSIONS
  This is the first but quasi-experimental study showing disrupted topology of the functional brain networks in MA abusers.
authors: Netherlands Institute for Neuroscience, Amsterdam, The Netherlands. m.ahmadlou@nin.knaw.nl
authors: Mehran
authors: M
authors: Ahmadlou
authors: Khodabakhsh
authors: K
authors: Ahmadi
authors: Majid
authors: M
authors: Rezazade
authors: Esfandiar
authors: E
authors: Azad-Marzabadi
mesh_terms: D000328:Adult; D000465:Algorithms; D019969:Amphetamine-Related Disorders / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D000697:Central Nervous System Stimulants; D016000:Cluster Analysis; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007360:Intelligence / Q000502:physiology; D008297:Male; D008694:Methamphetamine; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology*; D017711:Nonlinear Dynamics; D055815:Young Adult
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine