title: Management Of Metastatic Breast Cancer (MBC).
abstract: Chemotherapy of metastatic breast carcinoma so far, is not curative using the currently available chemotherapeutic, hormonal or biologic agents. The treatment of metastatic breast cancer is aimed mainly at alleviation of symptoms rather than cure. The first choice of therapy is dependent on patient age, performance status, hormone receptor status, human epidermal growth factor receptor-2 (HER-2), involvement of the viscera, or enrollment of patients in investigational trials. Combination of chemotherapeutic drugs showed an advantage for survival, tumor response and time to progression with adverse effects of these agents. It is very important, therefore, to balance between the benefits of treatment and the adverse effects and complication of therapy.
  
  
  BACKGROUND
  chemotherapy, metastatic, HER-2, breast, combination.
authors: Department of Internal Medicine, King Fahd Hospital of the University, Eastern Province, Al-Khobar 31952, Saudi Arabia. Email: aliamri49@hotmail.com.
authors: A
authors: A
authors: Al-Amri
mesh_terms: D001940:Breast; D001943:Breast Neoplasms; D006801:Humans