title: Oseltamivir inhibits both viral entry and release but enhances apoptosis of cells infected with influenza A H1N1.
abstract: Oseltamivir (Tamiflu) has been shown to be effective as a treatment and chemoprophylaxis for influenza virus infections. However, the safety consideration of oseltamivir should not be overlooked because adverse events associated with the drug have frequently been reported after the use of Tamiflu for the treatment of influenza patients. Here, we investigated oseltamivir's influence on viral load, apoptosis, and cytokine response of influenza A H1N1-infected A549 or THP-1 cells. In addition, we analyzed the effect of the drug on the function of influenza-infected NK cells after oseltamivir treatment. The results of our study suggest that oseltamivir may inhibit both viral entry and release but may also enhance apoptosis of infected cells and interfere with NK cell function during influenza infection.
authors: Dept. of Influenza, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100226, China.
authors: Rongbao
authors: R
authors: Gao
authors: Ning
authors: N
authors: Du
authors: Dongshan
authors: D
authors: Liu
authors: Zi
authors: Z
authors: Li
authors: Yun
authors: Y
authors: Zhu
authors: Yuelong
authors: Y
authors: Shu
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D016764:Cell Polarity / Q000187:drug effects; D016207:Cytokines / Q000037:antagonists & inhibitors; D004285:Dogs; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000502:physiology; D007694:Killer Cells, Natural / Q000187:drug effects; D061985:Madin Darby Canine Kidney Cells; D053139:Oseltamivir / Q000494:pharmacology*; D053586:Virus Internalization / Q000187:drug effects*; D057074:Virus Release / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D016207:Cytokines; D053139:Oseltamivir