title: Molecular machines directly observed by high-speed atomic force microscopy.
abstract: Molecular machines made of proteins are highly dynamic and carry out sophisticated biological functions. The direct and dynamic high-resolution visualization of molecular machines in action is considered to be the most straightforward approach to understanding how they function but this has long been infeasible until recently. High-speed atomic force microscopy has recently been realized, making such visualization possible. The captured images of myosin V, F1-ATPase, and bacteriorhodopsin have enabled their dynamic processes and structure dynamics to be revealed in great detail, giving unique and deep insights into their functional mechanisms.
authors: Department of Physics, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. tando@staff.kanazawa-u.ac.jp
authors: Toshio
authors: T
authors: Ando
mesh_terms: D001436:Bacteriorhodopsins / Q000737:chemistry / Q000378:metabolism; D018625:Microscopy, Atomic Force / Q000379:methods*; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D024701:Myosin Type V / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D055503:Protein Multimerization; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D006180:Proton-Translocating ATPases / Q000737:chemistry / Q000378:metabolism
chemical_list: D011506:Proteins; D001436:Bacteriorhodopsins; D024701:Myosin Type V; D006180:Proton-Translocating ATPases