title: [Changes to CD4(+)CD25(high+)CD127(low) regulatory T cells in peripheral blood from children with bronchiolitis, and its clinical significance].
abstract: OBJECTIVE
  To study changes to CD4(+)CD25(high+)CD127(low) regulatory T cells (Treg) in peripheral blood from children with bronchiolitis, and to explore its clinical significance.
  
  
  METHODS
  Thirty-one children with bronchiolitis and aged under two years were randomly enrolled as the bronchiolitis group, and 25 under two-year-olds with bronchopneumonia were randomly enrolled as the bronchopneumonia group. A further twenty-five children with non-infectious diseases such as hernia and renal calculus served as the control group. The level of CD4(+)CD25(high+)CD127(low) Treg in peripheral blood was measured by multi-color detection and multi-parameter flow cytometry.
  
  
  RESULTS
  The proportion of CD4(+)CD25(high+)CD127(low) Treg in peripheral blood in the bronchiolitis group (8.0%±2.1%) was significantly lower than in the bronchopneumonia (9.6%±2.6%; P<0.05) and control groups (11.3%±2.9%; P<0.05).
  
  
  CONCLUSIONS
  CD4(+)CD25(high+)CD127(low) Treg level in peripheral blood may be an index of immunological function in infants. A decreased level of CD4(+)CD25(high+)CD127(low) Treg in peripheral blood suggests that Treg cells may be involved in the pathogenesis and development of bronchiolitis.
authors: Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China. wxf456@126.com
authors: Xiu-Fang
authors: XF
authors: Wang
authors: Zhi-Lan
authors: ZL
authors: Guo
authors: Rui-Rui
authors: RR
authors: Lei
authors: Ying
authors: Y
authors: Han
mesh_terms: D001988:Bronchiolitis / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood*; D053699:Interleukin-7 Receptor alpha Subunit / Q000097:blood*; D008297:Male; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D053699:Interleukin-7 Receptor alpha Subunit