title: Reduced-antigen, combined diphtheria, tetanus, and acellular pertussis vaccine, adsorbed (boostrix(®)): a guide to its use as a single-dose booster immunization against pertussis.
abstract: Reduced-antigen, combined diphtheria, tetanus, and three-component acellular pertussis vaccine (Tdap; Boostrix(®)) is indicated for booster vaccination against diphtheria, tetanus, and pertussis. In clinical trials, a single booster dose of Tdap induced high seroprotective levels of antibodies to its three component acellular pertussis antigens in virtually all children and adolescents, and in a high proportion of adults and elderly individuals, at ≈1 month post-vaccination, irrespective of their vaccination history. Seropositivity rates for antibodies against pertussis toxin had begun to decline by 5 years after a booster dose of Tdap in adolescents/adults, with a subsequent booster dose 10 years later generally as immunogenic and as well tolerated as the initial booster. Tdap was safe and well tolerated in all age groups.
authors: Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore, 0754, Auckland, New Zealand, bdr@adis.com
authors: Lesley J
authors: LJ
authors: Scott
authors: Paul L
authors: PL
authors: McCormack
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology* / Q000493:pharmacokinetics; D004334:Drug Administration Schedule; D017408:Guidelines as Topic; D006801:Humans; D022282:Vaccines, Acellular / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology / Q000493:pharmacokinetics; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology / Q000493:pharmacokinetics; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000914:Antibodies, Viral; D000942:Antigens, Bacterial; C505143:Boostrix; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D022282:Vaccines, Acellular; D017778:Vaccines, Combined