title: [Influence of isoniazid complex with A-I apolipoprotein on activity of lysosomal enzymes in mice with tuberculous inflammation model].
abstract: It is established that isoniazid (isonicotinic acid hydrazide) can interact with A-I apolipoprotein to form a complex, which can be considered as the transport form of the preparation. The use of this complex for the treatment of mice with BCG-induced tuberculous inflammation led to an increase in the free activities of acid phosphatase and cathepsin D in the liver, which was decreased under the action of mycobacteria and the free form of isoniazid. The isoniazid complex with A-I apolipoprotein exhibited more expressed anti-inflammatory effect (estimated by the activity of chitotriosidase in blood serum) as compared to the free drug.
authors: D V
authors: DV
authors: Sumenkova
authors: L M
authors: LM
authors: Poliakov
authors: L E
authors: LE
authors: Panin
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D016632:Apolipoprotein A-I / Q000737:chemistry / Q000494:pharmacology*; D002402:Cathepsin D / Q000378:metabolism*; D004338:Drug Combinations; D006596:Hexosaminidases / Q000097:blood; D007274:Injections, Intraperitoneal; D007538:Isoniazid / Q000737:chemistry / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009163:Mycobacterium bovis / Q000187:drug effects; D014376:Tuberculosis / Q000188:drug therapy* / Q000201:enzymology / Q000382:microbiology; D015854:Up-Regulation
chemical_list: D000995:Antitubercular Agents; D016632:Apolipoprotein A-I; D004338:Drug Combinations; D000135:Acid Phosphatase; D006596:Hexosaminidases; C086400:chitotriosidase; D002402:Cathepsin D; D007538:Isoniazid