title: T cell metabolism and the immune response.
abstract: As T cells respond to pathogens, they must transition from a quiescent, naïve state, to a rapidly proliferating, active effector state, and back again to a quiescent state as they develop into memory cells. Such transitions place unique metabolic demands on the differentiating cells. T cells meet these demands by altering their metabolic profiles, which are, in turn, regulated by distinct signaling cascades and transcriptional programs. Here, we examine the metabolic profiles of T cells during an acute immune response and discuss the signal and transcriptional regulators of these metabolic changes.
authors: St. Jude Children's Research Hospital, Department of Immunology, 262 Danny Thomas Place, Memphis, TN 38105, United States. katherine.verbist@stjude.org
authors: Katherine C
authors: KC
authors: Verbist
authors: Ruoning
authors: R
authors: Wang
authors: Douglas R
authors: DR
authors: Green
mesh_terms: D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism