title: Bilateral analysis of the cross-sectional area of the internal mammary arteries and veins in patients with and without breast cancer on breast magnetic resonance imaging.
abstract: OBJECTIVE
  To analyse bilateral differences in the cross-sectional area of the internal mammary artery (IMA) and vein (IMV) in breast cancer patients compared to healthy controls.
  
  
  METHODS
  On 135 breast MRIs the cross-sectional areas of the IMA and IMV were measured on the left and right side in the second and third intercostal space (ICS) by two independent readers. Differences were analysed using a linear mixed model.
  
  
  RESULTS
  In the healthy control group (n = 91) no significant differences between the cross-sectional areas of the IMA and IMV were observed. Both readers reported a mean adjusted difference of 0.12 mm2 (p = 0.298) and 0.21 mm2 (p = 0.058) for the IMA in the second ICS. In the malignancy group (n = 44) the cross-sectional area was significantly larger on the malignancy side compared to the contralateral side. The largest difference in the IMA was measured in the second ICS with a mean adjusted difference for reader 1 of 1.37 mm2 (p < 0.001) and for reader 2 of 0.81 mm2 (p = 0.003).
  
  
  CONCLUSIONS
  The vascular cross-sectional area of internal mammary vessels was significantly different on the side with breast cancer compared to the contralateral side. This difference was not observed in healthy controls.
  
  
  CONCLUSIONS
  • MRI has become an important imaging modality in the diagnostic workup of breast cancer. • In healthy persons no significant difference in the size of the left and right IMA is observed. • A significant enlargement of the IMA on the malignant side occurs in most patients.
authors: Department of Surgery, Maastricht University Medical Center (Maastricht UMC), P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands, info@rjschipper.nl.
authors: Robert-Jan
authors: RJ
authors: Schipper
authors: Marc B I
authors: MB
authors: Lobbes
authors: Rieky E
authors: RE
authors: Dikmans
authors: Regina G H
authors: RG
authors: Beets-Tan
authors: Marjolein L
authors: ML
authors: Smidt
authors: Carla
authors: C
authors: Boetes