title: Association of insulin resistance indexes to carotid intima-media thickness.
abstract: OBJECTIVE
  Accumulating evidence suggests an association between insulin resistance (IR) and cardiovascular diseases The aim of this study was to examine the relationship between indexes of IR and common carotid intima-media thickness (IMT), an indicator of vascular damage.
  
  
  METHODS
  In 847 non-diabetic Caucasians a 75 g oral glucose tolerance test was performed and surrogate indexes of IR were computed according to published formulas. IMT was measured by ultrasound method.
  
  
  RESULTS
  The Stumvoll ISI(OGTT) index was correlated with IMT more strongly than the other indexes of IR. The IR indexes correlated significantly (P<0.0001) with all cardiovascular risk factors examined. The Stumvoll ISI(OGTT) index was correlated with waist circumference and high sensitivity C-reactive protein more strongly than the other indexes of IR. The area under the ROC curve (AUC), used to evaluate the accuracy of the IR indexes in identifying individuals with vascular damage defined as IMT >0.9 mm, for the Stumvoll ISI(OGTT) index was significantly higher (0.710) as compared with the AUCs of Matsuda (0.642) (P = 0.0009), OGIS (0.666) (P = 0.04), HOMA (0.611) (P<0.0001) and Liver IR (0.648) (P = 0.0008) indexes. In a logistic regression model adjusted for age and gender, subjects in the lowest tertile of the Stumvoll ISI(OGTT) index had the highest risk of having vascular damage (OR 4.95, 95% CI 2.99-8.192) as compared to the corresponding tertiles of the other surrogate indexes.
  
  
  CONCLUSIONS
  The Stumvoll ISI(OGTT) index correlated more strongly than other validated surrogates indexes of IR with carotid IMT, and, therefore, it might be a significant indicator of vascular damage.
authors: Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
authors: Angela
authors: A
authors: Sciacqua
authors: Maria Adelaide
authors: MA
authors: Marini
authors: Marta Letizia
authors: ML
authors: Hribal
authors: Francesco
authors: F
authors: Perticone
authors: Giorgio
authors: G
authors: Sesti
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic
chemical_list: D001786:Blood Glucose; D007328:Insulin