title: The phosphoinositide 3-kinase pathway is crucial for the growth of canine mast cell tumors.
abstract: Mast cell tumors (MCTs) are the most common tumors in dogs, accounting for 16-21% of cutaneous tumors. Although several small molecule inhibitors, including imatinib mesylate, have been used for the treatment of MCTs, the response rate remains less than 50%. In this study, the effects of different selective signal inhibitors on MCT cell growth were evaluated using 4 different cell lines derived from dogs. We found that the phosphoinositide 3-kinase (PI3K) signaling pathway is crucial for the proliferation of MCT cells in the presence or absence of c-kit gene mutations. Here, we propose a novel therapeutic strategy to target the PI3K pathway for the treatment of canine MCTs.
authors: Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
authors: Yosuke
authors: Y
authors: Amagai
authors: Akane
authors: A
authors: Tanaka
authors: Akira
authors: A
authors: Matsuda
authors: Kumiko
authors: K
authors: Oida
authors: Kyungsook
authors: K
authors: Jung
authors: Hiroshi
authors: H
authors: Matsuda
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004283:Dog Diseases / Q000201:enzymology*; D004285:Dogs; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D034801:Mastocytoma / Q000378:metabolism / Q000662:veterinary*; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism*; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D019009:Proto-Oncogene Proteins c-kit