title: Ovarian fibromatosis and sotos syndrome with a new genetic mutation.
abstract: BACKGROUND
  Sotos syndrome is one the most common overgrowth conditions, after Beckwith-Wiedemann syndrome. As with other overgrowth syndromes, Sotos syndrome can be associated with an increased risk of tumors.
  
  
  METHODS
  We describe a young girl with Sotos syndrome and ovarian fibromatosis with a new mutation not reported before in the literature.
  
  
  CONCLUSIONS
  Development of ovarian tumor in Sotos syndrome has been poorly documented. Ovarian fibromatosis is a very rare non neoplastic disease. Management is guided by the benignity of the lesion and consists of surgical excision of the fibroma.
authors: Department of Pediatric Surgery, Clinique chirurgicale et infantile, CHU Charles Nicolle, Rouen, France. marion.beurdeley@gmail.com
authors: M
authors: M
authors: Beurdeley
authors: J C
authors: JC
authors: Sabourin
authors: V
authors: V
authors: Drouin-Garraud
authors: A
authors: A
authors: Liard
authors: B
authors: B
authors: Bachy
authors: P H
authors: PH
authors: Vivier
mesh_terms: D002648:Child; D005091:Exons / Q000235:genetics; D005260:Female; D005350:Fibroma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D016133:Polymerase Chain Reaction; D058495:Sotos Syndrome / Q000175:diagnosis / Q000235:genetics*; D014463:Ultrasonography
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; C113272:NSD1 protein, human