title: Heterocyclic compounds based on 3-(4-bromophenyl) azo-5-phenyl-2(3H)-furanone: anti-avian influenza virus (H5N1) activity.
abstract: 1     3-[2-(4-Bromphenyl)hydrazono]-5-phenyl-furan-2(3H)-one () was used for preparation of some novel pyrazole, pyridazinone, oxadiazole, triazole, thiazolidine and thioxopyrimidine derivatives. Some of the prepared products were tested for anti-avian influenza virus activity and revealed promising antiviral activity against H5N1 virus [A/Chicken/Egypt/1/20 % (H5N1)] by determination of both EC50 and LD50 and confirmed by plaque reduction assay on Madin-Darby canine kidney cells. Compounds 3-[2-(4-bromophenyl)hydrazono]-5-phenylfuran-2(3H)-one (1), 1-(4-bromophenyl)-N-hydroxy-5-phenyl-1H-pyrazole-3-carboxamide (5) and 1-(4-bromophenyl)-N-{2,3-dihydro-4-hydroxy-3-phenyl-6-oxo-2-thioxopyrimidin-1(6H)-yl}-5-phenyl-1H-pyrazole-3-carboxamide (12a) showed the highest effects. Detailed synthesis, spectroscopic data, and antiviral activity of the synthesized compounds are reported.
authors: Department of Photochemistry National Research Centre, Cairo, Egypt. emanflefel@yahoo.com
authors: Eman M
authors: EM
authors: Flefel
authors: Randa E
authors: RE
authors: Abdel-Mageid
authors: Waled A
authors: WA
authors: Tantawy
authors: Mohamed A
authors: MA
authors: Ali
authors: Abd El-Galil E
authors: Ael-G
authors: Amr
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001391:Azo Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D001717:Birds; D002460:Cell Line; D004285:Dogs; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D009980:Influenza A virus / Q000187:drug effects*; D005585:Influenza in Birds / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D011720:Pyrazoles / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D001391:Azo Compounds; D011720:Pyrazoles; C031280:pyrazole; D015107:4-Butyrolactone