title: Temperature-insensitive detection of low-concentration nanoparticles using a functionalized high-Q microcavity.
abstract: The ability to detect nanoparticles in extremely dilute solutions in the presence of environmental noise is crucial for biosensing applications. In this paper we propose a scheme for detecting target nanoparticles through their scattering effects in a high-Q whispering gallery microcavity. The detection signal, defined as the total linewidth broadening of the two new split modes that appear upon nanoparticle adsorption, is highly sensitive and proportional to the nanoparticle concentration. Furthermore, this new method of detection eliminates the requirement for strict temperature control and is capable of distinguishing the signal from the biorecognitions (e.g., antibodies) initially attached to the resonator and that from the target nanoparticles (e.g., antigens).
authors: State Key Laboratory of Mesoscopic Physics and School of Physics, Peking University, Beijing 100871, China.
authors: Wei-Liang
authors: WL
authors: Jin
authors: Xu
authors: X
authors: Yi
authors: Yi-Wen
authors: YW
authors: Hu
authors: Bei-Bei
authors: BB
authors: Li
authors: Yun-Feng
authors: YF
authors: Xiao