title: Atorvastatin ameliorates podocyte injury in patients with type 2 diabetes complicated with dyslipidemia.
abstract: We examined the effects of atorvastatin on urinary podocyte excretion. Thirteen patients with type 2 diabetes receiving 2.5mg of rosuvastatin were recruited and the medication was switched to 10mg of atorvastatin for a 24-week period. With the switch to atorvastatin, the urinary excretion of podocytes was significantly reduced.
authors: Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan. minoru.takemoto@faculty.chiba-u.jp
authors: Minoru
authors: M
authors: Takemoto
authors: Takahiro
authors: T
authors: Ishikawa
authors: Shunichiro
authors: S
authors: Onishi
authors: Emiko
authors: E
authors: Okabe
authors: Ryoichi
authors: R
authors: Ishibashi
authors: Peng
authors: P
authors: He
authors: Kazuki
authors: K
authors: Kobayashi
authors: Masaki
authors: M
authors: Fujimoto
authors: Harukiyo
authors: H
authors: Kawamura
authors: Koutaro
authors: K
authors: Yokote
mesh_terms: D000368:Aged; D000069059:Atorvastatin; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000652:urine*; D003928:Diabetic Nephropathies / Q000150:complications / Q000188:drug therapy / Q000652:urine*; D050171:Dyslipidemias / Q000188:drug therapy / Q000209:etiology / Q000652:urine*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D050199:Podocytes / Q000187:drug effects* / Q000378:metabolism; D011758:Pyrroles / Q000627:therapeutic use*
chemical_list: D000069059:Atorvastatin; D015415:Biomarkers; D006442:Glycated Hemoglobin; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; C517652:hemoglobin A1c protein, human