title: The novel CTX-M-116 β-lactamase gene discovered in Proteus mirabilis is composed of parts of the CTX-M-22 and CTX-M-23 genes.
abstract: The novel β-lactamase gene bla(CTX-M-116) was identified in a Proteus mirabilis nosocomial isolate recovered from the urine of a patient in Moscow in 2005. DNA sequence analysis showed bla(CTX-M-116) to be a hybrid gene consisting of 5' bla(CTX-M-23) (nucleotides 1 to 278) and 3' bla(CTX-M-22) (nucleotides 286 to 876) moieties separated by an intervening putative site of recombination (GTTAAAT). A retrospective analysis of available bla(CTX-M) genes in the GenBank database revealed 19 bla(CTX-M) genes that display the same hybrid structure.
authors: The State Research Center for Applied Microbiology & Biotechnology, Obolensk, Russia. fursova@obolensk.org
authors: N
authors: N
authors: Fursova
authors: S
authors: S
authors: Pryamchuk
authors: A
authors: A
authors: Kruglov
authors: I
authors: I
authors: Abaev
authors: E
authors: E
authors: Pecherskikh
authors: N
authors: N
authors: Kartsev
authors: E
authors: E
authors: Svetoch
authors: I
authors: I
authors: Dyatlov
mesh_terms: D001483:Base Sequence; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology; D030561:Databases, Nucleic Acid; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D020033:Protein Isoforms / Q000235:genetics; D011512:Proteus Infections / Q000188:drug therapy / Q000382:microbiology; D011513:Proteus mirabilis / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification*; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*; D047090:beta-Lactams / Q000627:therapeutic use
chemical_list: D029968:Escherichia coli Proteins; D020033:Protein Isoforms; D047090:beta-Lactams; D001618:beta-Lactamases; C542394:beta-lactamase CTX-M-22, E coli; C492229:beta-lactamase CTX-M-23, E coli