title: The indoor level of house dust mite allergen is associated with severity of atopic dermatitis in children.
abstract: We attempted to investigate the correlation between the severity of atopic dermatitis (AD) in children and the indoor level of house dust mite (HDM) allergens. Ninety-five patients (31.1 ± 19.5 months of age) with AD were enrolled in this study, and serum specific IgE against Dermatophagoides pteronyssinus and D. farinae was measured. The severity of AD was assessed using the visual analogue scale on the same day of house dust collection. Living rooms and mattresses where the child usually slept were vacuumed for 2 minutes and concentrations of Der f 1 were measured by enzyme-linked immunosorbent assay. The skin symptoms were more severe in patients with Der f 1 concentrations in living room > 2 µg/g dust than ≤ 2 µg/g dust (P = 0.018). This difference was noted in AD patients without sensitization to HDM (P = 0.004), but not in patients with sensitization. There was no difference in symptom severity according to Der f 1 concentrations in mattresses (P = 0.062). The severity of skin symptoms is associated with indoor concentrations of HDM in children with AD, and it is likely to act as nonspecific irritants as well as allergens in AD skin lesions.
authors: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Jihyun
authors: J
authors: Kim
authors: Sangwoon
authors: S
authors: Lee
authors: Sook-young
authors: SY
authors: Woo
authors: Youngshin
authors: Y
authors: Han
authors: Jung Hyun
authors: JH
authors: Lee
authors: In-Yong
authors: IY
authors: Lee
authors: In-Seok
authors: IS
authors: Lim
authors: Eung-Sang
authors: ES
authors: Choi
authors: Byoung-Whi
authors: BW
authors: Choi
authors: Hae-Kwan
authors: HK
authors: Cheong
authors: Sang-Il
authors: SI
authors: Lee
authors: Kangmo
authors: K
authors: Ahn
mesh_terms: D000293:Adolescent; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000032:analysis*; D001513:Beds / Q000469:parasitology; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000473:pathology; D040001:Dermatophagoides farinae / Q000276:immunology; D040002:Dermatophagoides pteronyssinus / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008297:Male; D012720:Severity of Illness Index
chemical_list: D039741:Antigens, Dermatophagoides; D007073:Immunoglobulin E
keywords: Allergens; Atopic Dermatitis; House Dust Mite