title: Polydextrose results in a dose-dependent reduction in ad libitum energy intake at a subsequent test meal.
abstract: Previous studies have reported that polydextrose can reduce food intake; however, the optimal dose required to achieve this effect is currently unknown. The present study investigated the effects of consuming a range of doses of polydextrose on appetite and energy intake (EI) using a randomised within-subject, cross-over design. For this purpose, twenty-one participants (n 12 men, n 9 women) consumed an 837 kJ liquid preload containing 0 g (control), 6.3, 12.5 or 25 g polydextrose. Subjective appetite ratings were collected using visual analogue scales and an ad libitum test meal was served 90 min later. Participants recorded EI for the remainder of the day in a food diary. Test meal EI following the control preload (5756 (sem 423) kJ) was significantly higher than following the 6.3 g (5048 (sem 384) kJ), 12.5 g (4722 (sem 384) kJ) and 25 g (4362 (sem 316) kJ) preloads (P< 0.05), and EI following the 6.3 g preload was significantly higher than following the 25 g preload (P< 0.01). There were no differences in self-reported EI during the remainder of the day between the preloads containing the varying doses of polydextrose. Total EI (breakfast+preload+ad libitum test meal+remainder of the day) was significantly higher when the control preload was consumed (12,051 (sem 805) kJ) compared with either the 12.5 g (10,854 (sem 589) kJ) or 25 g (10,658 (sem 506) kJ) preload (P< 0.05). These differences in EI were not accompanied by corresponding differences in subjective appetite ratings. In summary, polydextrose effectively reduces subsequent EI in a dose-dependent manner.
authors: School of Biomedical Sciences, E Floor Medical School, University of Nottingham, Queen's Medical School Campus, Nottingham NG7 2UH, UK.
authors: Nerys M
authors: NM
authors: Astbury
authors: Moira A
authors: MA
authors: Taylor
authors: Ian A
authors: IA
authors: Macdonald
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake; D005260:Female; D005503:Food Additives / Q000008:administration & dosage / Q000494:pharmacology*; D005936:Glucans / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D062407:Meals; D055815:Young Adult
chemical_list: D005503:Food Additives; D005936:Glucans; C033375:polydextrose