title: Macrolide therapy for chronic rhinosinusitis: a meta-analysis.
abstract: OBJECTIVE
  The objective of this study was to systematically review patient-reported outcomes of long-term macrolide therapy, compared with any other treatment, for adults with chronic rhinosinusitis.
  
  
  METHODS
  EMBASE and PubMed databases were searched in October 2011.
  
  
  METHODS
  A total of 1216 citations were screened initially by a single author, 23 full-text manuscripts were evaluated by 2 authors using structured data abstraction forms to assess for inclusion criteria and study quality, and 3 studies were included in the final review.
  
  
  RESULTS
  This review finds that 3 prospective clinical studies have evaluated the effect of macrolide therapy for chronic rhinosinusitis. Based on the limited data, there is limited scientific evidence to support the use of long-term macrolide therapy for chronic rhinosinusitis.
  
  
  CONCLUSIONS
  Further clinical research is needed to determine whether there may be a subgroup effect based on the underlying inflammatory disease process.
authors: Department of Otolaryngology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA. pynnonen@umich.edu
authors: Melissa A
authors: MA
authors: Pynnonen
authors: Giri
authors: G
authors: Venkatraman
authors: Greg E
authors: GE
authors: Davis
mesh_terms: D000328:Adult; D002908:Chronic Disease; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use*; D012220:Rhinitis / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*
chemical_list: D018942:Macrolides