title: Metabolism of inflammation limited by AMPK and pseudo-starvation.
abstract: Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1α and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.
authors: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland. laoneill@tcd.ie
authors: Luke A J
authors: LA
authors: O'Neill
authors: D Grahame
authors: DG
authors: Hardie
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008264:Macrophages / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D037761:Sirtuins / Q000378:metabolism; D013217:Starvation / Q000139:chemically induced / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D055372:AMP-Activated Protein Kinases; D037761:Sirtuins; D005947:Glucose