title: Aerosolised heparin in the treatment of Fontan-related plastic bronchitis.
abstract: Patients with Fontan palliation and single-ventricle physiology encounter multiple comorbidities including plastic bronchitis, a disease characterised by the plugging of small and large airways by rubbery, white casts. To date, no controlled clinical trials have demonstrated effective treatment of plastic bronchitis. We report the application of aerosolised heparin, which has published success in non-cardiac-related pulmonary disease, for this complication in a Fontan patient.
authors: 1 Division of Pediatric Cardiology, Miller School of Medicine, University of Miami, Miami, Florida.
authors: Daniel E
authors: DE
authors: Eason
authors: 2 Department of Pediatrics, Clinical Pharmacy, Richmond, Virginia, United States of America.
authors: Kristin
authors: K
authors: Cox
authors: 3 Division of Pediatric Cardiology, Children's Hospital of Richmond at VCU Medical Center, Richmond, Virginia, United States of America.
authors: William B
authors: WB
authors: Moskowitz
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D001991:Bronchitis / Q000150:complications / Q000188:drug therapy*; D002675:Child, Preschool; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D018729:Fontan Procedure; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000601:surgery*; D006352:Heart Ventricles / Q000002:abnormalities / Q000601:surgery*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D011666:Pulmonary Valve Stenosis / Q000150:complications / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D005343:Fibrinolytic Agents; D006493:Heparin