title: Stereochemical Studies of Ag-Catalyzed Hosomi-Sakurai Reaction Using Chiral Silanes.
abstract: Stereochemical aspect of asymmetric Ag-catalyzed Hosomi-Sakurai reaction with ketones has been investigated. Several allyltrimethoxysilanes have been synthesized and used for the asymmetric reaction. Remarkably, among several possible diastereomers only two are generated with high levels of diastereo- and enantioselectivities. Based on the observations for different allyltimethoxysilanes, we hypothesize formation of a single allylsilver species which undergoes addition to the ketone.
authors: Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637.
authors: Manabu
authors: M
authors: Wadamoto
authors: Marina
authors: M
authors: Naodovic
authors: Hisashi
authors: H
authors: Yamamoto