title: Detection of some volatile degradation products released during photoexposition of ranitidine in a solid state.
abstract: Ranitidine (RAN) is on top of the list of prescribed drugs, due to its popularity as a selective H2-receptor antagonist, which efficiently decreases the amount of acid produced in the stomach. RAN is not stable both in a solid state and in a solution, which creates manufacturing problems, requires appropriate storage conditions, and results in a short drug shelf-life. The aim of this work was to study the emission of volatile degradation products generated during photoexposition of ranitidine hydrochloride in a solid state. Significant changes in volatile profile of irradiated RAN were detected using HS-SPME-GC-MS. Sixteen major peaks were noticed on the chromatograms of irradiated ranitidine and the structures of some compounds were elucidated, while the presence of acetaldoxime, thiazole, dimethylformamide, dimethylacetamide and 5-methylfurfural was confirmed by means of the analysis of the authentic standards.
authors: Department of Physical Chemistry, Medical University of Gdansk, Faculty of Pharmacy with Subfaculty of Laboratory Medicine, 80-416 Gdańsk, Al. Gen. Hallera 107, Poland. majam@gumed.edu.pl
authors: Marzena
authors: M
authors: Jamrógiewicz
authors: Bartosz
authors: B
authors: Wielgomas
mesh_terms: D004355:Drug Stability; D004356:Drug Storage; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006207:Half-Life; D006635:Histamine H2 Antagonists / Q000737:chemistry*; D010782:Photolysis; D011899:Ranitidine / Q000737:chemistry*; D052617:Solid Phase Microextraction
chemical_list: D006635:Histamine H2 Antagonists; D011899:Ranitidine