title: 18F-fluorodeoxyglucose-positron emission tomography scanning is a useful tool for therapy evaluation of arterial aneurysm in Behçet's disease.
abstract: [(18)F]fluorodeoxyglucose-positron emission tomography (FDG-PET) has demonstrated its usefulness in giant cell arteritis, Takayasu's arteritis, and unclassified aortitis. FDG-PET imaging could be more effective than CT-scan or magnetic resonance imaging in detecting the earliest stages of vascular wall inflammation. Data are lacking regarding its accuracy for diagnosis and follow-up of vascular lesions in Behçet's disease. We report the case of a 32-year-old woman with history of Behçet's disease and fever of unknown origin revealing voluminous pulmonary arterial aneurysms. FDG-PET scan revealed a peripheral uptake of pulmonary aneurysms, underlying the inflammatory status of arterial aneurysms wall. Our patient was treated by glucocorticoids and intravenous cyclophosphamide and achieved remission of Behçet's disease. During follow-up, FDG-PET scan enabled to detect an early radiologic therapeutic response after 4 months, while CT angiography remained unchanged. We report the first evidence of usefulness of FDG-PET scan for therapeutic evaluation of arterial aneurysms in Behçet's disease. Further studies are warranted to determine the accuracy of FDG-PET scan in larger cohort of Behçet's disease patients with vascular involvement.
authors: Internal Medicine department, hôpital Ambroise-Paré, 92104 Boulogne-Billancourt, France. salim.trad@apr.aphp.fr
authors: Salim
authors: S
authors: Trad
authors: Lyza
authors: L
authors: Bensimhon
authors: Mostafa
authors: M
authors: El Hajjam
authors: Thierry
authors: T
authors: Chinet
authors: Bertrand
authors: B
authors: Wechsler
authors: David
authors: D
authors: Saadoun
mesh_terms: D000328:Adult; D000783:Aneurysm / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000453:epidemiology; D001528:Behcet Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000453:epidemiology; D015897:Comorbidity; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D019788:Fluorodeoxyglucose F18; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D049268:Positron-Emission Tomography; D011651:Pulmonary Artery / Q000000981:diagnostic imaging*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D019788:Fluorodeoxyglucose F18; D003520:Cyclophosphamide
keywords: Arterial aneurysms; Behçet's disease; FDG-PET scan; Therapeutic evaluation; [(18)F]fluorodeoxyglucose-positron emission tomography