title: The possible role of antioxidant vitamin C in Alzheimer's disease treatment and prevention.
abstract: Oxidative stress is suggested to play a major role in the pathogenesis of Alzheimer's disease (AD). Among the antioxidants, vitamin C has been regarded as the most important one in neural tissue. It also decreases β-amyloid generation and acetylcholinesterase activity and prevents endothelial dysfunction by regulating nitric oxide, a newly discovered factor in the pathogenesis and progression of AD. However, clinical trials using antioxidants, including vitamin C, in patients with AD yielded equivocal results. The current article discusses the relevance of vitamin C in the cellular and molecular pathogenesis of AD and explores its therapeutic potential against this neurodegenerative disorder.
authors: Department of Neurology, Seoul Medical Center, Seoul, Korea.
authors: Jae-Hyeok
authors: JH
authors: Heo
authors: Hyon-Lee
authors: Kyoung-Min
authors: KM
authors: Lee
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D000975:Antioxidants / Q000502:physiology / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000502:physiology / Q000627:therapeutic use*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D000975:Antioxidants; D001205:Ascorbic Acid