title: Characterization of an acid-inducible sulfatase in Salmonella enterica serovar typhimurium.
abstract: Sulfatases of enteric bacteria can provide access to heavily sulfated mucosal glycans. In this study, we show that aslA (STM0084) of Salmonella enterica serovar Typhimurium LT2 encodes a sulfatase that requires mildly acidic pH for its expression and activity. AslA is not regulated by sulfur compounds or tyramine but requires the EnvZ-OmpR and PhoPQ regulatory systems, which play an important role in pathogenesis.
authors: Department of Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA.
authors: Seema
authors: S
authors: Das
authors: Swati
authors: S
authors: Singh
authors: Michael
authors: M
authors: McClelland
authors: Steven
authors: S
authors: Forst
authors: Prasad
authors: P
authors: Gyaneshwar
mesh_terms: D000143:Acids / Q000378:metabolism*; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D006863:Hydrogen-Ion Concentration; D012486:Salmonella typhimurium / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D013429:Sulfatases / Q000096:biosynthesis* / Q000235:genetics*; D015533:Transcriptional Activation
chemical_list: D000143:Acids; D001426:Bacterial Proteins; D013429:Sulfatases