title: Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration.
abstract: The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions essential for cellular homeostasis, development, and stress responsiveness. In response to cellular stress, a well-established signaling cascade, the unfolded protein response (UPR), is activated. This intricate mechanism is an important means of re-establishing cellular homeostasis and alleviating the inciting stress. Now, emerging evidence has demonstrated that the UPR influences cellular metabolism through diverse mechanisms, including calcium and lipid transfer, raising the prospect of involvement of these processes in the pathogenesis of disease, including neurodegeneration, cancer, diabetes mellitus and cardiovascular disease. Here, we review the distinct functions of the ER and UPR from a metabolic point of view, highlighting their association with prevalent pathologies.
authors: Center for Molecular Studies of the Cell, University of Chile, Santiago, Chile.
authors: Roberto
authors: R
authors: Bravo
authors: Valentina
authors: V
authors: Parra
authors: Damián
authors: D
authors: Gatica
authors: Andrea E
authors: AE
authors: Rodriguez
authors: Natalia
authors: N
authors: Torrealba
authors: Felipe
authors: F
authors: Paredes
authors: Zhao V
authors: ZV
authors: Wang
authors: Antonio
authors: A
authors: Zorzano
authors: Joseph A
authors: JA
authors: Hill
authors: Enrique
authors: E
authors: Jaimovich
authors: Andrew F G
authors: AF
authors: Quest
authors: Sergio
authors: S
authors: Lavandero
mesh_terms: D000818:Animals; D004194:Disease; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D059748:Proteolysis; D056811:Unfolded Protein Response