title: Sustained remission from depressive-like behavior depends on hippocampal neurogenesis.
abstract: Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments.
authors: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
authors: A
authors: A
authors: Mateus-Pinheiro
authors: L
authors: L
authors: Pinto
authors: J M
authors: JM
authors: Bessa
authors: M
authors: M
authors: Morais
authors: N D
authors: ND
authors: Alves
authors: S
authors: S
authors: Monteiro
authors: P
authors: P
authors: Patrício
authors: O F X
authors: OF
authors: Almeida
authors: N
authors: N
authors: Sousa
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism / Q000494:pharmacology*; D001253:Astrocytes / Q000187:drug effects / Q000473:pathology; D001522:Behavior, Animal / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003213:Conditioning, Psychological; D003863:Depression / Q000188:drug therapy* / Q000473:pathology; D005473:Fluoxetine / Q000378:metabolism / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D007099:Imipramine / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D008746:Methylazoxymethanol Acetate / Q000031:analogs & derivatives / Q000494:pharmacology; D055495:Neurogenesis / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000378:metabolism / Q000473:pathology
chemical_list: D000928:Antidepressive Agents; D005473:Fluoxetine; D008746:Methylazoxymethanol Acetate; D007099:Imipramine