title: cobas 8000 Modular analyzer series evaluated under routine-like conditions at 14 sites in Australia, Europe, and the United States.
abstract: Clinical laboratories need to test patient samples precisely, accurately, and efficiently. The latest member of the Roche cobas modular platform family, the cobas 8000 modular analyzer series allows compact and convenient consolidation of clinical chemistry and immunochemistry assays in high-workload laboratories with a throughput of 3 to 15 million tests annually. Here we present the results of studies designed to test the overall system performance under routine-like conditions that were conducted at 14 laboratories over 2 y. Experiments that test analytical performance of the new module were integrated with overall system functionality testing of all modules in different configurations. More than two million results were generated and evaluated for ~100 applications using serum/plasma, urine, or EDTA blood samples. During the workflow studies, eight configurations of the possible 38 combinations were used, covering all available analytical modules. The versatility of the module combinations makes the system customizable to fit the needs of diverse laboratories, allowing precise and accurate analysis of a broad spectrum of clinical chemistry and immunochemistry parameters with short turnaround times. This new system will contribute to the ability of clinical laboratories to offer better service to their customers and support vital clinical decision making.
authors: Institut für Klinische Chemie, Universitätsspital Zürich, Zürich, Switzerland.
authors: Arnold
authors: A
authors: von Eckardstein
authors: Hans Jürgen
authors: HJ
authors: Roth
authors: Graham
authors: G
authors: Jones
authors: Sharon
authors: S
authors: Preston
authors: Thomas
authors: T
authors: Szekeres
authors: Roland
authors: R
authors: Imdahl
authors: Marc
authors: M
authors: Conti
authors: Norbert
authors: N
authors: Blanckaert
authors: Darren
authors: D
authors: Jose
authors: Joachim
authors: J
authors: Thiery
authors: Lisa
authors: L
authors: Feldmann
authors: Nicolas
authors: N
authors: von Ahsen
authors: Massimo
authors: M
authors: Locatelli
authors: Jenni
authors: J
authors: Kremastinou
authors: Albert
authors: A
authors: Kunst
authors: Arnulf
authors: A
authors: Hubbuch
authors: Margaret
authors: M
authors: McGovern
mesh_terms: D001315:Australia; D057205:Automation, Laboratory; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation* / Q000592:standards; D019411:Clinical Laboratory Techniques / Q000295:instrumentation*; D003955:Diagnostic Tests, Routine; D005060:Europe; D057166:High-Throughput Screening Assays; D006801:Humans; D046210:Microfluidic Analytical Techniques; D015203:Reproducibility of Results; D014481:United States
keywords: analytical modules; analytical performance; analyzers; practicability assessment; workflow analysis