title: Experimental infection and natural contact exposure of ferrets with canine influenza virus (H3N2).
abstract: Epidemics of H3N2 canine influenza virus (CIV) among dogs in South Korea and southern China have raised concern over the potential for zoonotic transmission of these viruses. Here, we analysed the pathogenesis and transmissibility of H3N2 CIV in ferret. H3N2 CIV replicated efficiently in the respiratory system of inoculated ferrets and caused acute necrotizing bronchioalveolitis and non-suppurative encephalitis. Transmission of H3N2 CIV was detected in three of six ferrets co-housed with inoculated ferrets, but no viruses were detected in second-contact ferrets. These findings show that H3N2 CIV has the capacity to replicate in and transmit partially among co-housed ferrets and underscore the need for continued public health surveillance.
authors: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors: Yu-Na
authors: YN
authors: Lee
authors: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors: Dong-Hun
authors: DH
authors: Lee
authors: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors: Jae-Keun
authors: JK
authors: Park
authors: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors: Seong-Su
authors: SS
authors: Yuk
authors: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors: Jung-Hoon
authors: JH
authors: Kwon
authors: Laboratory of Veterinary Anatomy, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors: Sang-Soep
authors: SS
authors: Nahm
authors: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors: Joong-Bok
authors: JB
authors: Lee
authors: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors: Seung-Yong
authors: SY
authors: Park
authors: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors: In-Soo
authors: IS
authors: Choi
authors: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors: Chang-Seon
authors: CS
authors: Song
mesh_terms: D000818:Animals; D001996:Bronchopneumonia / Q000473:pathology / Q000821:virology; D018562:Disease Transmission, Infectious; D004285:Dogs; D018792:Encephalitis, Viral / Q000473:pathology / Q000635:transmission / Q000821:virology; D005289:Ferrets; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000302:isolation & purification / Q000472:pathogenicity*; D009976:Orthomyxoviridae Infections / Q000473:pathology* / Q000635:transmission* / Q000821:virology