title: Effect of eccentric training on mitochondrial function and oxidative stress in the skeletal muscle of rats.
abstract: The objective of the present study was to investigate the effects of eccentric training on the activity of mitochondrial respiratory chain enzymes, oxidative stress, muscle damage, and inflammation of skeletal muscle. Eighteen male mice (CF1) weighing 30-35 g were randomly divided into 3 groups (N = 6): untrained, trained eccentric running (16°; TER), and trained running (0°) (TR), and were submitted to an 8-week training program. TER increased muscle oxidative capacity (succinate dehydrogenase and complexes I and II) in a manner similar to TR, and TER did not decrease oxidative damage (xylenol and creatine phosphate) but increased antioxidant enzyme activity (superoxide dismutase and catalase) similar to TR. Muscle damage (creatine kinase) and inflammation (myeloperoxidase) were not reduced by TER. In conclusion, we suggest that TER improves mitochondrial function but does not reduce oxidative stress, muscle damage, or inflammation induced by eccentric contractions.
authors: Laboratório de Fisiologia e Bioquímica do Exercício, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brasil. luciano_acordi@yahoo.com.br
authors: L A
authors: LA
authors: Silva
authors: K F
authors: KF
authors: Bom
authors: C B
authors: CB
authors: Tromm
authors: G L
authors: GL
authors: Rosa
authors: I
authors: I
authors: Mariano
authors: B G
authors: BG
authors: Pozzi
authors: T
authors: T
authors: Tuon
authors: E L
authors: EL
authors: Stresck
authors: C T
authors: CT
authors: Souza
authors: R A
authors: RA
authors: Pinho
mesh_terms: D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D051379:Mice; D008931:Mitochondria, Muscle / Q000378:metabolism / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000502:physiology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D009195:Peroxidase / Q000097:blood; D010805:Physical Conditioning, Animal / Q000502:physiology*; D005082:Physical Exertion; D051381:Rats; D013385:Succinate Dehydrogenase / Q000097:blood
chemical_list: D009195:Peroxidase; D013385:Succinate Dehydrogenase; D003402:Creatine Kinase