title: Preparation of highly functionalised benzofurans from ortho-hydroxyphenones and dichloroethylene: applications and mechanistic investigations.
abstract: Highly functionalised benzofurans have been prepared from ortho-hydroxyphenones and 1,1-dichloroethylene. The key intermediate, a chloromethylene furan, smoothly rearranged into the corresponding benzofuran carbaldehyde under acidic conditions. Some mechanistic investigations have been performed and several biologically active benzofurans have been synthesised.
authors: Laboratory of Organic and Medicinal Chemistry, Université catholique de Louvain, Place Louis Pasteur 1 bte L4.01.02, 1348 Louvain-la-Neuve, Belgium.
authors: Florian
authors: F
authors: Schevenels
authors: Bernard
authors: B
authors: Tinant
authors: Jean-Paul
authors: JP
authors: Declercq
authors: István E
authors: IE
authors: Markó
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D004000:Dichloroethylenes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; D004000:Dichloroethylenes; D007659:Ketones; C035384:1,2-dichloroethylene