title: [Epidemiological situation and the E gene evolution of dengue virus in Guangzhou, 2011].
abstract: OBJECTIVE
  To investigate the epidemiological characteristics of Dengue and the E gene of the new isolated strains.
  
  
  METHODS
  Epidemiological data and serum samples were collected. Serotypes were detected by real-time PCR and virus was isolated in C6/36. E gene of the new isolated strains were sequenced and analyzed by Mega 4.0.
  
  
  RESULTS
  The cases of Dengue reached at the peak during September and November, with Serotype 1, 2 and 4 were involved. Five strains of serotype l were isolated, with 4 of them fell into the clad of Asia genotype, and 1 belonged to America/Africa genotype.
  
  
  CONCLUSIONS
  The strains isolated in Guangzhou showed a high identity to the Southeast Asian strains. There seemed high risk of outbreak of Dengue in this area, However, the Dengue virus might have already been localized.
authors: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
authors: Li-yun
authors: LY
authors: Jiang
authors: Yi-min
authors: YM
authors: Cao
authors: Yang
authors: Y
authors: Xu
authors: Qin-long
authors: QL
authors: Jing
authors: Qing
authors: Q
authors: Cao
authors: Biao
authors: B
authors: DI
authors: Zhi-cong
authors: ZC
authors: Yang
mesh_terms: D002681:China / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology* / Q000821:virology; D003716:Dengue Virus / Q000235:genetics* / Q000302:isolation & purification; D019143:Evolution, Molecular; D005838:Genotype; D006801:Humans; D015994:Incidence; D017720:Molecular Epidemiology; D012367:RNA, Viral / Q000235:genetics; D014759:Viral Envelope Proteins / Q000235:genetics*
chemical_list: D012367:RNA, Viral; D014759:Viral Envelope Proteins; C072281:E protein TH Sman, Dengue virus