title: Respiratory viral infections after hematopoietic stem cell transplantation in children.
abstract: This study was performed to characterize respiratory viral infections in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). Study samples included 402 respiratory specimens obtained from 358 clinical episodes that occurred in the 116 children of the 175 consecutive HSCT cohort at Seoul National University Children's Hospital, Korea from 2007 to 2010. Multiplex reverse-transcription polymerase chain reactions were performed for rhinovirus, respiratory syncytial virus (RSV), parainfluenza viruses (PIVs), adenovirus, human coronavirus (hCoV), influenza viruses and human metapneumovirus. Viruses were identified in 89 clinical episodes that occurred in 58 patients. Among the 89 clinical episodes, frequently detected viruses were rhinovirus in 25 (28.1%), RSV in 23 (25.8%), PIV-3 in 16 (18.0%), adenovirus in 12 (13.5%), and hCoV in 10 (11.2%). Lower respiratory tract infections were diagnosed in 34 (38.2%). Neutropenia was present in 24 (27.0%) episodes and lymphopenia was in 31 (34.8%) episodes. Sixty-three percent of the clinical episodes were hospital-acquired. Three patients died of respiratory failure caused by respiratory viral infections. Respiratory viral infections in pediatric patients who have undergone HSCT are common and are frequently acquired during hospitalization. Continuous monitoring is required to determine the role of respiratory viruses in immunocompromised children and the importance of preventive strategies.
authors: Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.
authors: Jae Hong
authors: JH
authors: Choi
authors: Eun Hwa
authors: EH
authors: Choi
authors: Hyoung Jin
authors: HJ
authors: Kang
authors: Kyung Duk
authors: KD
authors: Park
authors: Sung Sup
authors: SS
authors: Park
authors: Hee Young
authors: HY
authors: Shin
authors: Hoan Jong
authors: HJ
authors: Lee
authors: Hyo Seop
authors: HS
authors: Ahn
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000302:isolation & purification; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D017934:Coronavirus / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008231:Lymphopenia / Q000453:epidemiology; D008297:Male; D009503:Neutropenia / Q000453:epidemiology; D010224:Parainfluenza Virus 3, Human / Q000235:genetics / Q000302:isolation & purification; D015995:Prevalence; D012136:Respiratory Syncytial Viruses / Q000235:genetics / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000628:therapy / Q000821:virology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012229:Rhinovirus / Q000235:genetics / Q000302:isolation & purification; D012621:Seasons; D055815:Young Adult
keywords: Hematopoietic Stem Cell Transplantation; Respiratory Infections; Respiratory Virus