title: Obliterative bronchiolitis in fibreglass workers: a new occupational disease?
abstract: OBJECTIVE
  Obliterative bronchiolitis (OB) is a rare disease with a small number of established occupational aetiologies. We describe a case series of severe OB in workers making glass-reinforced plastics.
  
  
  METHODS
  Workplace exposures were the likely cause after the independent diagnosis of OB in two workers laying up the fibreglass hulls of yachts; the second worker took over the job of the first after he left following a lung transplant. Presentation of these two cases at international meetings led to others identifying similar workers.
  
  
  RESULTS
  We identified six workers with good evidence of OB. All were involved in preparing fibreglass with styrene resins, five as boat builders laying up fibreglass hulls and one during cooling-tower fabrication. The disease came on rapidly without unusual acute exposures. Two patients had lung transplants, while another died while waiting for one. Histology confirmed OB in the four with biopsies/post-mortem examinations or explanted lungs.
  
  
  CONCLUSIONS
  A rare, potentially fatal disease occurring in six workers laying up fibreglass with styrene resins from five different worksites suggests that work exposures were the cause of their OB. The precise agent responsible awaits identification.
authors: Occupational and Environmental Medicine, National Heart & Lung Institute, Imperial College London, London, UK. p.cullinan@imperial.ac.uk
authors: Paul
authors: P
authors: Cullinan
authors: Clive R
authors: CR
authors: McGavin
authors: Kathleen
authors: K
authors: Kreiss
authors: Andrew G
authors: AG
authors: Nicholson
authors: Toby M
authors: TM
authors: Maher
authors: Tim
authors: T
authors: Howell
authors: John
authors: J
authors: Banks
authors: Anthony J
authors: AJ
authors: Newman Taylor
authors: Chi-Hsien
authors: CH
authors: Chen
authors: Perng-Jy
authors: PJ
authors: Tsai
authors: Tung-Sheng
authors: TS
authors: Shih
authors: P Sherwood
authors: PS
authors: Burge
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects; D001344:Autopsy; D001989:Bronchiolitis Obliterans / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D003252:Construction Materials / Q000009:adverse effects*; D017809:Fatal Outcome; D005898:Glass; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects; D008168:Lung / Q000187:drug effects / Q000473:pathology; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D016273:Occupational Exposure / Q000009:adverse effects*; D009790:Occupations; D010969:Plastics; D012117:Resins, Synthetic / Q000009:adverse effects*; D012720:Severity of Illness Index; D012767:Ships; D020058:Styrene / Q000009:adverse effects*
chemical_list: D000395:Air Pollutants, Occupational; D010969:Plastics; D012117:Resins, Synthetic; C009753:fiberglass; D020058:Styrene