title: Short- and long-term risk of colorectal adenoma recurrence among whites and blacks.
abstract: BACKGROUND
  It is unclear whether the higher burden from colorectal cancer among blacks is due to an increased biological susceptibility.
  
  
  OBJECTIVE
  To determine whether non-Hispanic blacks (blacks) have a higher risk of adenoma recurrence than non-Hispanic whites (whites) after removal of colorectal adenoma.
  
  
  METHODS
  Secondary analysis of the Polyp Prevention Trial (PPT) data.
  
  
  METHODS
  United States.
  
  
  METHODS
  Patients were 1668 self-identified whites and 153 blacks who completed the 4-year trial. Of these, 688 whites and 55 blacks enrolled in a posttrial, passive Polyp Prevention Trial Continued Follow-up Study (PPT-CFS) and underwent another colonoscopy.
  
  
  METHODS
  Recurrence and location of the adenoma and advanced adenoma by race-ethnicity during PPT and cumulative recurrence over a mean follow-up of 8.3 years (range, 4.9-12.4 years) among PPT-CFS enrollees.
  
  
  RESULTS
  Blacks had similar risk of recurrence of adenoma (39.2% vs 39.4%; incidence risk ratio [RR] = .98; 95% CI, .80-1.20) and advanced adenoma (8.5% vs 6.4%; RR = 1.18; 95% CI, .68-2.05) as whites at the end of PPT. Recurrence risk did not differ by colon subsite. Among PPT-CFS enrollees, the cumulative recurrence rate over a maximal follow-up period of 12 years was similar for blacks and whites for adenoma (67.3% vs 67.0%; RR = 1.01; 95% CI, .84-1.21) and advanced adenoma (14.5% vs 16.9%; RR = 1.03; 95% CI, .60-1.79).
  
  
  CONCLUSIONS
  There were few blacks in the long-term follow-up study.
  
  
  CONCLUSIONS
  Adenoma and advanced adenoma recurrence did not differ by race. Our study does not support more frequent surveillance colonoscopies for blacks with a personal history of adenoma as an intervention to reduce colorectal cancer disparity.
authors: Department of Medicine, Howard University Hospital, Washington, DC, USA. adeyinka.laiyemo@howard.edu.
authors: Adeyinka O
authors: AO
authors: Laiyemo
authors: Chyke
authors: C
authors: Doubeni
authors: Hassan
authors: H
authors: Brim
authors: Hassan
authors: H
authors: Ashktorab
authors: Robert E
authors: RE
authors: Schoen
authors: Samir
authors: S
authors: Gupta
authors: Aline
authors: A
authors: Charabaty
authors: Elaine
authors: E
authors: Lanza
authors: Duane T
authors: DT
authors: Smoot
authors: Elizabeth
authors: E
authors: Platz
authors: Amanda J
authors: AJ
authors: Cross
mesh_terms: D000236:Adenoma / Q000208:ethnology* / Q000601:surgery; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D016009:Chi-Square Distribution; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000208:ethnology* / Q000601:surgery; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000208:ethnology*; D018709:Statistics, Nonparametric; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data*