title: High dietary fiber intake prevents stroke at a population level.
abstract: OBJECTIVE
  This research was aimed at clarifying whether high dietary fiber intake has an impact on incidence and risk of stroke at a population level.
  
  
  METHODS
  In 1647 unselected subjects, dietary fiber intake (DFI) was detected in a 12-year population-based study, using other dietary variables, anagraphics, biometrics, blood pressure, heart rate, blood lipids, glucose, insulin, uricaemia, fibrinogenaemia, erytrosedimentation rate, diabetes, insulin resistance, smoking, pulmonary disease and left ventricular hypertrophy as covariables.
  
  
  RESULTS
  In adjusted Cox models, high DFI reduced the risk of stroke. In analysis based on quintiles of fiber intake adjusted for confounders, HR for incidence of stroke was lower when the daily intake of soluble fiber was >25 g or that of insoluble fiber was >47 g. In multivariate analyses, using these values as cut-off of DFI, the risk of stroke was lower in those intaking more that the cut-off of soluble (HR 0.31, 0.17-0.55) or insoluble (HR 0.35, 0.19-0.63) fiber. Incidence of stroke was also lower (-50%, p < 0.003 and -46%, p < 0.01, respectively).
  
  
  CONCLUSIONS
  Higher dietary DFI is inversely and independently associated to incidence and risk of stroke in general population.
authors: Department of Medicine, University of Padova, Via Giustiniani 2, I-35128 Padua, Italy. Electronic address: edoardo.casiglia@unipd.it.
authors: Edoardo
authors: E
authors: Casiglia
authors: Valérie
authors: V
authors: Tikhonoff
authors: Sandro
authors: S
authors: Caffi
authors: Giovanni
authors: G
authors: Boschetti
authors: Carla
authors: C
authors: Grasselli
authors: Mario
authors: M
authors: Saugo
authors: Nunzia
authors: N
authors: Giordano
authors: Valentina
authors: V
authors: Rapisarda
authors: Paolo
authors: P
authors: Spinella
authors: Paolo
authors: P
authors: Palatini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004043:Dietary Fiber / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012995:Solubility; D020521:Stroke / Q000453:epidemiology / Q000517:prevention & control*; D011795:Surveys and Questionnaires; D016019:Survival Analysis; D055815:Young Adult
keywords: Blood pressure; Cerebrovascular; Cholesterol; Epidemiology; Fiber; Fibre; Human; Population; Risk