title: Sleep disruption in spinocerebellar ataxia type 3: a genetic and polysomnographic study.
abstract: BACKGROUND
  Sleep structure disruption and rapid eye movement (REM) sleep behavior disorders (RBD) have been previously reported in patients with neurodegenerative diseases. However, similar studies have rarely been quantitatively conducted in type 3 spinocerebellar ataxia (SCA3).
  
  
  METHODS
  Fifteen patients with SCA3 and 16 healthy controls were recruited and evaluated by clinical history, International Cooperative Ataxia Rating Scale (ICARS), Epworth sleepiness scale (ESS), and polysomnography.
  
  
  RESULTS
  Patients with SCA3 had reductions in sleep efficiency and percentage of REM sleep, which were negatively correlated with the severity of ataxia as evaluated by ICARS. REM sleep reduction occurred regardless of the presence of RBD, and severe reduction of REM sleep may significantly disturb the assessment of RBD.
  
  
  CONCLUSIONS
  Poor sleep efficiency and REM sleep aberrations are the characteristics of sleep structure disruption in SCA3 as the disease progresses. The incidence of respiratory disturbance during sleep or excessive daytime sleepiness was not significantly higher in SCA3 patients than controls.
authors: Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, ROC.
authors: Nai-Fang
authors: NF
authors: Chi
authors: Guang-Ming
authors: GM
authors: Shiao
authors: Hsiao-Lun
authors: HL
authors: Ku
authors: Bing-Wen
authors: BW
authors: Soong
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D017827:Machado-Joseph Disease / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020187:REM Sleep Behavior Disorder / Q000209:etiology*