title: Initial findings and potential applicability of computational simulation of the aorta in acute type B dissection.
abstract: OBJECTIVE
  Type B aortic dissection can be acutely complicated by rapid expansion, rupture, and malperfusion syndromes. Short-term adverse outcomes are associated with failure of the false lumen to thrombose. The reasons behind false lumen patency are poorly understood, and the objective of this pilot study was to use computational fluid dynamics reconstructions of aortic dissection cases to analyze the effect of aortic and primary tear morphology on flow characteristics and clinical outcomes in patients with acute type B dissections.
  
  
  METHODS
  Three-dimensional patient-specific aortic dissection geometry was reconstructed from computed tomography scans of four patients presenting with acute type B aortic dissection and a further patient with sequential follow-up scans. The cases were selected based on their clinical presentation. Two were complicated by acute malperfusion that required emergency intervention. Three patients were uncomplicated and were managed conservatively. The patient-specific aortic models were used in computational simulations to assess the effect of aortic tear morphology on various parameters including flow, velocity, shear stress, and turbulence.
  
  
  RESULTS
  Pulsatile flow simulation results showed that flow rate into the false lumen was dependent on both the size and position of the primary tear. Linear regression analysis demonstrated a significant relationship between percentage flow entering the false lumen and the size of the primary entry tear and an inverse relationship between false lumen flow and the site of the entry tear. Subjects complicated by malperfusion had larger-dimension entry tears than the uncomplicated cases (93% and 82% compared with 32% and 55%, respectively). Blood flow, wall shear stress, and turbulence levels varied significantly between subjects depending on aortic geometry. Highest wall shear stress (>7 Pa) was located at the tear edge, and progression of false lumen thrombosis was associated with prolonged particle residence times.
  
  
  CONCLUSIONS
  Results obtained from this preliminary work suggest that aortic morphology and primary entry tear size and position exert significant effects on flow and other hemodynamic parameters in the dissected aorta in this preliminary work. Blood flow into the false lumen increases with increasing tear size and proximal location. Morphologic analysis coupled with computational fluid dynamic modeling may be useful in predicting acute type B dissection behavior allowing for selection of proper treatment modalities, and further confirmatory studies are warranted.
authors: Department of Chemical Engineering, Imperial College London, London, United Kingdom.
authors: Zhuo
authors: Z
authors: Cheng
authors: Celia
authors: C
authors: Riga
authors: Joyce
authors: J
authors: Chan
authors: Mohammad
authors: M
authors: Hamady
authors: Nigel B
authors: NB
authors: Wood
authors: Nicholas J W
authors: NJ
authors: Cheshire
authors: Yun
authors: Y
authors: Xu
authors: Richard G J
authors: RG
authors: Gibbs
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000784:Aortic Dissection / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D001011:Aorta / Q000503:physiopathology*; D001014:Aortic Aneurysm / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D001027:Aortography / Q000379:methods; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity; D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D011379:Prognosis; D011673:Pulsatile Flow; D012039:Regional Blood Flow; D013314:Stress, Mechanical; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014654:Vascular Patency