title: The o-mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophy.
abstract: Several forms of congenital muscular dystrophy, referred to as dystroglycanopathies, result from defects in the protein O-mannosylation biosynthetic pathway. In this minireview, I discuss 12 proteins involved in the pathway and how they play a role in the building of glycan structures (most notably on the protein α-dystroglycan) that allow for binding to multiple proteins of the extracellular matrix.
authors: Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA.
authors: Lance
authors: L
authors: Wells
mesh_terms: D000818:Animals; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006023:Glycoproteins / Q000378:metabolism*; D006031:Glycosylation; D016695:Glycosyltransferases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008358:Mannose / Q000378:metabolism*; D009136:Muscular Dystrophies / Q000151:congenital / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D015398:Signal Transduction
chemical_list: D006023:Glycoproteins; D016695:Glycosyltransferases; D008358:Mannose