title: The STAR of the DLC family.
abstract: RhoGTPases are defined as a family of 20 small G proteins playing important roles in almost every cellular process. RhoGTPases are guanine nucleotide-binding proteins existing in two forms: the active form which is GTP bound and the inactive one that being GDP bound. RhoGTPase-activating proteins known as RhoGAPs constitute one of the major classes of regulators of RhoGTPases. They act as negative regulators of the RhoGTPases by enhancing their slow intrinsic GTPase activity. STARD13, a GTPase activating protein (GAP) for RhoGTPases, has been described as a tumor suppressor in hepatocellular carcinoma. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13.
authors: Department of Natural Sciences, Lebanese American University, Beirut Campus, Beirut, Lebanon.
authors: Sally
authors: S
authors: El-Sitt
authors: Mirvat
authors: M
authors: El-Sibai
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D020690:GTPase-Activating Proteins; C473607:STARD13 protein, human; D025521:Tumor Suppressor Proteins; C085379:rho GTPase-activating protein; D020741:rho GTP-Binding Proteins