title: Palatability and treatment efficacy of various ibuprofen formulations in C57BL/6 mice with ulcerative dermatitis.
abstract: Ibuprofen, a nonsteroidal antiinflammatory drug, is a nonselective inhibitor of cyclooxygenases 1 and 2 that commonly is used for its analgesic, antiinflammatory, and antipyretic properties. We compared the palatability and efficacy of medicated water containing ibuprofen from an oral  pediatric suspension or liqui-gel capsules in C57BL/6 and genetically engineered mice of C57BL/6 background with ulcerative dermatitis. Mice (n = 14 or 15 per group) with ulcerated skin lesions of similar average size (capsule group, 6.71 mm(2); suspension group, 6.12 mm(2))  received ibuprofen in their drinking water at a concentration of 1 mg/mL. Water and food consumption, locomotor activity, grooming frequency, and reduction in pruritic behavior and lesion size were measured over a 9-d period. Compared with those treated with water containing the suspension,  mice that received medicated water containing the liqui-gel formulation drank more (mean, 6.8 compared with 11.7 mL/d), consumed more food (4.02 compared with 2.73 g/d), and showed less pruritic behavior, greater healing (mean, 29.3% compare with 64.8%), and more locomotor activity over a  9-d period.
authors: Division of Laboratory Animal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. ezellp@musc.edu
authors: Paula C
authors: PC
authors: Ezell
authors: Luis
authors: L
authors: Papa
authors: Gregory W
authors: GW
authors: Lawson
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use; D003872:Dermatitis / Q000188:drug therapy / Q000662:veterinary; D004326:Drinking; D005260:Female; D007052:Ibuprofen / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011897:Random Allocation; D012376:Rodent Diseases / Q000188:drug therapy*; D012883:Skin Ulcer / Q000188:drug therapy / Q000662:veterinary*; D012995:Solubility; D013649:Taste; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen