title: Use of clinical practice guidelines on long-term prophylaxis in severe hemophilia in France: a retrospective audit.
abstract: OBJECTIVE
  To evaluate the impact of the 2002 guidelines on the current status of prophylaxis in French children with severe hemophilia A or B.
  
  
  METHODS
  Clinical information was captured, in a prospective way, using FranceCoag Network. We retrospectively studied 291 patients with severe (<1 IU/dL) hemophilia A and B, with no history of inhibitors.
  
  
  RESULTS
  Our results demonstrate that the availability of national medical guidelines has improved clinical practice in France. In the past decade, the proportion of children with severe hemophilia undergoing prophylaxis has shown a significant 2- to 3-fold increase: ∼80% of these children>3 years of age are now receiving prophylaxis. In severe hemophilia A and B, the age at which prophylaxis commences has significantly decreased: 4.0 and 6.1 years for the period 1996-1999 as opposed to 1.8 and 1.4 years for the period 2004-2007 (P=.0001).
  
  
  CONCLUSIONS
  Long-term clinical and physical evaluations of patients will be necessary to establish the benefits of this increase in prophylactic treatment on the prevention of hemophilic arthropathy.
authors: Hemophilia Center, University Hospital Edouard Herriot, Lyon, France.
authors: Sandrine
authors: S
authors: Meunier
authors: Hervé
authors: H
authors: Chambost
authors: Virginie
authors: V
authors: Demiguel
authors: Alexandra
authors: A
authors: Doncarli
authors: Florence
authors: F
authors: Suzan
authors: Marc
authors: M
authors: Trossaërt
mesh_terms: D002648:Child; D002675:Child, Preschool; D054869:Clinical Audit; D005260:Female; D005602:France; D006467:Hemophilia A / Q000150:complications / Q000188:drug therapy*; D002836:Hemophilia B / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007592:Joint Diseases / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies