title: Rapid αβ T-cell responses orchestrate innate immunity in response to Staphylococcal enterotoxin A.
abstract: In the generation of a traditional immune response against invading pathogens, innate cells guide T cells by programming their differentiation. However, here we demonstrate that αβ T cells have an essential role in priming innate immunity in the lung after Staphylococcus aureus enterotoxin A (SEA) inhalation. We found that SEA induces waves of cellular activation, cytokine production, and migration into the lung tissue and airways. However, this innate response was completely inhibited in the absence of αβ T cells. Specifically, we found that interleukin (IL)-17A was required for the recruitment of neutrophils and monocytes into the lung. The cellular source of IL-17A was γδ T cells, which increased their IL-17A production following SEA but only in an αβ T-cell-dependent manner. Thus, rapid T-cell activation orchestrates innate immunity and may be a new point of therapeutic intervention for acute lung injury.
authors: Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut, USA.
authors: S
authors: S
authors: Kumar
authors: S L
authors: SL
authors: Colpitts
authors: A
authors: A
authors: Ménoret
authors: A L
authors: AL
authors: Budelsky
authors: L
authors: L
authors: Lefrancois
authors: A T
authors: AT
authors: Vella
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002465:Cell Movement; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D004768:Enterotoxins / Q000008:administration & dosage; D007113:Immunity, Innate; D020381:Interleukin-17 / Q000378:metabolism; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D016207:Cytokines; D004768:Enterotoxins; D020381:Interleukin-17; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; C026066:enterotoxin A, Staphylococcal