title: Non-alcoholic steatohepatitis occurs in celiac disease and is associated with cellular stress.
abstract: OBJECTIVE
  Liver and gut not only share alimentary but also immunological features. Major histocompatibility complex class I-related chains A and B (MIC A/B) function as indicators for cellular stress. These so called stress-induced ligands are suggested to play an important role in the progression of non-alcoholic fatty liver disease (NAFLD) and are a prominent feature of celiac disease (CD).
  
  
  METHODS
  In the present study, 24 patients with celiac disease and 20 patients with non-alcoholic steatohepatitis (NASH) were included. Liver enzymes, serum cell death markers (M30, M65), MIC B and expression of adiponectin were determined.
  
  
  RESULTS
  Mean patient age was 42 years (18 - 69) for CD and 49 years (33 - 68) for the NASH group. ALT and AST values were lower in CD compared to NASH patients. While serum cell death markers were higher in NASH, the predominant type of cell death in CD was apoptosis. Also, expression of MIC B was significantly up-regulated in CD patients as compared to NASH patients. Adiponectin values were significantly lower in NASH compared to CD patients.
  
  
  CONCLUSIONS
  Stress-induced ligands and apoptosis are induced in CD. Prospective studies need to determine the exact role of cellular stress and apoptosis in the gut-liver axis and the clinical implications to screen for NAFLD in CD patients.
authors: Department of Gastroenterology and Hepatology, University Hospital Essen, Germany.
authors: J
authors: J
authors: Kälsch
authors: L P
authors: LP
authors: Bechmann
authors: P
authors: P
authors: Manka
authors: A
authors: A
authors: Kahraman
authors: M
authors: M
authors: Schlattjan
authors: T
authors: T
authors: Marth
authors: K
authors: K
authors: Rehbehn
authors: H A
authors: HA
authors: Baba
authors: A
authors: A
authors: Canbay
mesh_terms: D052242:Adiponectin / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000276:immunology; D002446:Celiac Disease / Q000276:immunology*; D005234:Fatty Liver / Q000276:immunology*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D018384:Oxidative Stress / Q000276:immunology*; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D007155:Immunologic Factors