title: Parathyroid hormone-independent hypercalcemia in an infant with renal dysplasia: possible role of PTHrP.
abstract: BACKGROUND
  Parathyroid hormone (PTH)-independent hypercalcemia in patients with chronic kidney failure is a rare and poor understood entity.
  
  
  METHODS
  We report the case of an infant with stage III chronic kidney failure secondary to multicystic dysplastic kidney disease, who presented at 3 months of life with severe hypercalcemia, suppressed PTH, and elevated PTH-related peptide. Malignancy was discarded, and the patient was treated twice with bisphosphonates with an initial partial response. During follow-up, the calcium levels descended. To date, he has maintained normal serum calcium level for 1 year after discharge.
  
  
  CONCLUSIONS
  The presence of PTH-related peptide may play a role in hypercalcemia associated to multicystic dysplastic kidney disease possibly by the overproduction of this peptide in the kidney.
authors: Division of Pediatrics, Pontificia Universidad Católica, Santiago, Chile.
authors: Francisca
authors: F
authors: Grob
authors: Pedro
authors: P
authors: Zambrano
authors: Ximena
authors: X
authors: Ibarra
authors: María Loreto
authors: ML
authors: Reyes
mesh_terms: D006801:Humans; D006934:Hypercalcemia / Q000209:etiology* / Q000378:metabolism; D007223:Infant; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000378:metabolism; D008297:Male; D021782:Multicystic Dysplastic Kidney / Q000150:complications* / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood*; D044162:Parathyroid Hormone-Related Protein / Q000097:blood*
chemical_list: D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein