title: Epigenetic abnormalities in cancer find a "home on the range".
abstract: Recent studies have highlighted large genomic regions prone to undergo epigenetic changes in cancers. In this issue of Cancer Cell, Bert and colleagues describe novel genomic domains with aberrant epigenetic changes involving concordant activation of neighboring genes. These domains involve aberrant CpG-island hypermethylation similar to that observed in gene silencing.
authors: The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. heaswar2@jhmi.edu
authors: Hariharan
authors: H
authors: Easwaran
authors: Stephen B
authors: SB
authors: Baylin