title: Jatropholane-type diterpenes from Euphorbia sikkimensis.
abstract: Four new jatropholane-type diterpenes (1-4), named sikkimenoids A-D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1-4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC(50) value of 43.0 μM when evaluated using a zebrafish model.
authors: Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
authors: Da-Song
authors: DS
authors: Yang
authors: You-Li
authors: YL
authors: Zhang
authors: Wei-Bing
authors: WB
authors: Peng
authors: Li-Yan
authors: LY
authors: Wang
authors: Zi-Lei
authors: ZL
authors: Li
authors: Xue
authors: X
authors: Wang
authors: Ke-Chun
authors: KC
authors: Liu
authors: Yong-Ping
authors: YP
authors: Yang
authors: Hong-Lin
authors: HL
authors: Li
authors: Xiao-Li
authors: XL
authors: Li
mesh_terms: D000465:Algorithms; D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D004195:Disease Models, Animal; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D015027:Zebrafish
chemical_list: D020533:Angiogenesis Inhibitors; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C580673:sikkimenoid B