title: Endogenous electric currents might guide rostral migration of neuroblasts.
abstract: Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field strength of ∼3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration.
authors: Department of Dermatology, University of California, Davis, 3301 C Street, Sacramento, California 95816, USA.
authors: Lin
authors: L
authors: Cao
authors: Dongguang
authors: D
authors: Wei
authors: Brian
authors: B
authors: Reid
authors: Siwei
authors: S
authors: Zhao
authors: Jin
authors: J
authors: Pu
authors: Tingrui
authors: T
authors: Pan
authors: Ebenezer
authors: E
authors: Yamoah
authors: Min
authors: M
authors: Zhao
mesh_terms: D000818:Animals; D002465:Cell Movement; D002552:Cerebral Ventricles / Q000166:cytology; D017097:Electric Impedance; D004558:Electric Stimulation; D004566:Electrodes; D055785:Gene Knockdown Techniques; D066298:In Vitro Techniques; D051379:Mice; D058953:Neural Stem Cells / Q000187:drug effects / Q000502:physiology*; D009830:Olfactory Bulb / Q000166:cytology; D058921:Purinergic P2Y Receptor Antagonists / Q000494:pharmacology; D034741:RNA, Small Interfering / Q000235:genetics; D058472:Receptors, Purinergic P2Y1 / Q000502:physiology*; D013498:Suramin / Q000494:pharmacology
chemical_list: D058921:Purinergic P2Y Receptor Antagonists; D034741:RNA, Small Interfering; D058472:Receptors, Purinergic P2Y1; D013498:Suramin