title: Epidemiology of bloodstream infections in children with sickle cell disease.
abstract: The incidence of invasive Streptococcus pneumoniae and Haemophilus influenzae type b infections in the sickle cell disease population has declined. In this report, we determine the predominant organisms responsible for bloodstream infections in a pediatric sickle cell disease population during the postheptavalent conjugate vaccine era. Central venous access device associated infections are a new burden to efforts aimed at preventing bloodstream infections in this population.
authors: Division of Emergency Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. ellisona@email.chop.edu
authors: Angela M
authors: AM
authors: Ellison
authors: Kaede V
authors: KV
authors: Ota
authors: Karin L
authors: KL
authors: McGowan
authors: Kim
authors: K
authors: Smith-Whitley
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D001419:Bacteria / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D002405:Catheterization, Central Venous; D002648:Child; D002675:Child, Preschool; D006801:Humans; D015994:Incidence; D007223:Infant; D015143:Philadelphia / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents