title: Reovirus modulates autophagy during oncolysis of multiple myeloma.
abstract: Multiple myeloma (MM) is a clonal plasma cell malignancy that accounts for 10-15% of newly diagnosed hematological cancers. Although significant advances have been made in the treatment of MM the disease still remains incurable. The oncolytic potential of reovirus has previously been demonstrated by others and us and is currently in phase III clinical trials for solid tumors. In addition a phase I clinical trial has recently been initiated for MM. Despite the clinical activity, the mechanism(s) of cell death caused by reovirus in MM is yet not yet well elucidated. A comprehensive understanding of reovirus-mediated histology-specific cell death mechanisms is imperative if this therapeutic is to become a standard of care for patients. Previously we have shown that reovirus-mediated cell death of breast and prostate cancer is orchestrated via apoptosis. The present study demonstrates for the first time that in addition to inducing apoptosis reovirus also upregulates autophagy during oncolysis of MM.
authors: Department of Oncology, University of Calgary, Calgary, Alberta, Canada.
authors: Chandini M
authors: CM
authors: Thirukkumaran
authors: Zhong Qiao
authors: ZQ
authors: Shi
authors: Joanne
authors: J
authors: Luider
authors: Karen
authors: K
authors: Kopciuk
authors: He
authors: H
authors: Gao
authors: Nizar
authors: N
authors: Bahlis
authors: Paola
authors: P
authors: Neri
authors: Mark
authors: M
authors: Pho
authors: Doug
authors: D
authors: Stewart
authors: Adnan
authors: A
authors: Mansoor
authors: Don G
authors: DG
authors: Morris
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D001343:Autophagy; D045744:Cell Line, Tumor; D002986:Clinical Trials as Topic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D009101:Multiple Myeloma / Q000378:metabolism / Q000628:therapy*; D050130:Oncolytic Virotherapy / Q000379:methods*; D012087:Reoviridae / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents
keywords: apoptosis; autophagy; multiple myeloma; reovirus