title: Acid-sensing ion channels (ASICs) in the taste buds of adult zebrafish.
abstract: In detecting chemical properties of food, different molecules and ion channels are involved including members of the acid-sensing ion channels (ASICs) family. Consistently ASICs are present in sensory cells of taste buds of mammals. In the present study the presence of ASICs (ASIC1, ASIC2, ASIC3 and ASIC4) was investigated in the taste buds of adult zebrafish (zASICs) using Western blot and immunohistochemistry. zASIC1 and zASIC3 were regularly absent from taste buds, whereas faint zASIC2 and robust zASIC4 immunoreactivities were detected in sensory cells. Moreover, zASIC2 also immunolabelled nerves supplying taste buds. The present results demonstrate for the first time the presence of zASICs in taste buds of teleosts, with different patterns to that occurring in mammals, probably due to the function of taste buds in aquatic environment and feeding. Nevertheless, the role of zASICs in taste remains to be demonstrated.
authors: Departamento de Morfología y Biología Celular, Grupo SINPOS, Universidad de Oviedo, Spain.
authors: E
authors: E
authors: Viña
authors: V
authors: V
authors: Parisi
authors: R
authors: R
authors: Cabo
authors: R
authors: R
authors: Laurà
authors: S
authors: S
authors: López-Velasco
authors: A
authors: A
authors: López-Muñiz
authors: O
authors: O
authors: García-Suárez
authors: A
authors: A
authors: Germanà
authors: J A
authors: JA
authors: Vega
mesh_terms: D062565:Acid Sensing Ion Channels / Q000378:metabolism*; D000818:Animals; D009055:Mouth / Q000166:cytology / Q000294:innervation / Q000378:metabolism; D012867:Skin / Q000166:cytology / Q000294:innervation / Q000378:metabolism; D013650:Taste Buds / Q000378:metabolism*; D015027:Zebrafish / Q000378:metabolism*
chemical_list: D062565:Acid Sensing Ion Channels