title: Uterine rudiments in patients with Mayer-Rokitansky-Küster-Hauser syndrome consist of typical uterine tissue types with predominantly basalis-like endometrium.
abstract: OBJECTIVE
  To analyze the histologic and immunohistochemical structure of uterine rudiments focusing on the endometrium in a representative group of patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome compared with a control group.
  
  
  METHODS
  Prospective comparative study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Forty-two patients with MRKH syndrome and 13 control subjects.
  
  
  METHODS
  Representative biopsies or whole uterine rudiments were removed during surgery and processed by a standardized procedure including immunohistochemical staining and analysis.
  
  
  METHODS
  Histologic structure, tissue types, hormone receptor expression, endometrial proliferative capacity, and type in correlation with cycle phase.
  
  
  RESULTS
  Twenty-two of the uterine rudiments showed a duct-like structure or small cavity, 17 of which contained endometrial epithelium and CD10-positive stroma. All rudiments contained an intact myometrial layer. Tubal epithelium and stroma were found in three rudiment samples. No significant differences were observed with regard to estrogen receptor (ER) or progesterone receptor (PR) expression in endometrium or myometrium. Interestingly, patients showed predominantly basalis-like endometrium with specific lack of CD90 expression and significantly lower proliferation compared with controls.
  
  
  CONCLUSIONS
  All typical uterine tissues can be found in uterine rudiments of patients with MRKH syndrome. Expression of hormonal receptors in the latter and controls did not differ significantly. Endometrium shows predominantly basalis-like features in uterine rudiments.
authors: Department of Obstetrics and Gynaecology, University Hospital, Tübingen, Germany. katharina.rall@med.uni-tuebingen.de
authors: Katharina
authors: K
authors: Rall
authors: Gianmaria
authors: G
authors: Barresi
authors: Diethelm
authors: D
authors: Wallwiener
authors: Sara Y
authors: SY
authors: Brucker
authors: Annette
authors: A
authors: Staebler
mesh_terms: D058489:46, XX Disorders of Sex Development; D015746:Abdominal Pain / Q000473:pathology / Q000601:surgery; D000015:Abnormalities, Multiple / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D000013:Congenital Abnormalities; D004717:Endometrium / Q000002:abnormalities* / Q000378:metabolism / Q000473:pathology; D004958:Estradiol / Q000097:blood; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000002:abnormalities / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D009095:Mullerian Ducts / Q000002:abnormalities / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D011374:Progesterone / Q000097:blood; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D019170:Somites / Q000002:abnormalities / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D013131:Spine / Q000002:abnormalities / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D014599:Uterus / Q000002:abnormalities* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D014621:Vagina / Q000002:abnormalities* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D055815:Young Adult
chemical_list: D043373:Follicle Stimulating Hormone, Human; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone