title: Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand.
abstract: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has dual functions mediating both apoptosis and survival of cells. This review focusses on the current regulatory factors that control TRAIL transcription. Here, we also highlight the role of distinct transcription factors that co-operate and regulate TRAIL in different pathological states. A better understanding of the molecular signalling pathways of TRAIL-induced cell death and survival in disease may lead to more sophisticated technologies for novel therapeutic targets.
authors: Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia.
authors: Nor Saadah M
authors: NS
authors: Azahri
authors: Mary M
authors: MM
authors: Kavurma
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D015398:Signal Transduction; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D053221:TNF-Related Apoptosis-Inducing Ligand