title: Low blood lead concentrations and thyroid function of American adults.
abstract: Lead is often present in our environment, but its effect on thyroid function is still unclear. In this study, multiple linear regressions were performed between log-transformed blood lead levels and thyroid function parameters of 4652 adults from the 2007-2008 National Health and Nutrition Examination Survey. The models were adjusted for age, gender, race/ethnicity, smoking, alcohol consumption, body mass index, physical activity, iodine intake, medications, and bone mineral density. Blood lead concentrations (mean: 1.52 ± 1.20 μg/dL [range 0.18-33.12]) were inversely associated with total thyroxine (regression coefficients [β]: -0.22 [95% CI: -0.34, -0.09] in the general population, but were not correlated with thyroid stimulating hormone, total or free triiodothyronine, nor free thyroxine. Blood lead may have no effect on the thyroid function; however, it could be associated with decreased concentrations in thyroid-binding proteins.
authors: a Epidemiology , Florida International University , Miami , USA .
authors: Angelico
authors: A
authors: Mendy
authors: Janvier
authors: J
authors: Gasana
authors: Edgar Ramos
authors: ER
authors: Vieira
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007118:Immunoassay; D007854:Lead / Q000097:blood*; D016014:Linear Models; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D009749:Nutrition Surveys; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*; D014481:United States; D055815:Young Adult
chemical_list: D014284:Triiodothyronine; D007854:Lead; D013972:Thyrotropin; D013974:Thyroxine