title: Meta-analysis of MMP9-562C/T and the risk of coronary heart disease.
abstract: BACKGROUND
  Previous case-control studies have suggested that the -1562C/T and R279Q polymorphisms of the matrix metalloproteinase 9 gene (MMP9) are associated with coronary heart disease (CHD). However, other studies do not confirm these relationships. The objective is to assess these relationships using meta-analysis.
  
  
  METHODS
  Databases, including PubMed and ScienceDirect, were searched to access the genetic association studies. Then data were extracted. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Moreover, subgroup and sensitive analysis were performed.
  
  
  RESULTS
  The meta-analysis of the -1562C/T polymorphism included 12 studies with 8,336 cases and 3,984 controls. The -1562T allele was significantly associated with CHD (OR 1.25, 95% CI 1.08-1.45, p = 0.004). There was heterogeneity among the 12 studies (I2 = 61%, p = 0.003). The overall results were consistent and were not changed substantially by the removal of any data set. The meta-analysis of the R279Q polymorphism, including 6 studies with 6,983 cases and 3,282 controls, showed that the R279Q polymorphism was not associated with CHD (p = 0.16).
  
  
  CONCLUSIONS
  The synthesis of available evidence supports the fact that the MMP9 -1562C/T polymorphism is a risk factor for CHD.
authors: Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Department of Endocrinology, Diabetes Research Institute, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, PR China. lijunyan323@gmail.com
authors: Junyan
authors: J
authors: Li
authors: Hao
authors: H
authors: Lu
authors: Feng
authors: F
authors: Tao
authors: Hua
authors: H
authors: Zhou
authors: Guoyying
authors: G
authors: Feng
authors: Lin
authors: L
authors: He
authors: Ligang
authors: L
authors: Zhou
mesh_terms: D003327:Coronary Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D020780:Matrix Metalloproteinase 9