title: The effect of bioactive complex of quercetin, selenium, catechins and curcumin on cardiovascular risk markers in healthy population after a two month consumption.
abstract: BACKGROUND
  Nutrition is an important factor in prevention of degenerative age-related diseases. Health benefits of the functional food - cereal selenized onion biscuits with bioactive complex such as selenium in organic form, quercetin (onion), curcumin (curcuma) and catechins (green tea) were evaluated.
  
  
  METHODS
  In a group of randomly selected 50 apparently healthy men, aged 30-50 years, the levels of total cholesterol, HDL-cholesterol, C-reactive protein (hs-CRP), homocysteine (HCy) and its nutritional determinants (methionine, vitamin B12, folic acid, cysteine, vitamin B6) and asymmetric dimethylarginine (ADMA) were measured and the LDL cholesterol and atherogenic index was calculated before and after a 2-month consumption period and after a 2-month wash-out period.
  
  
  RESULTS
  The significant reduction of total cholesterol, LDL-cholesterol, atherogenic index, HCy and ADMA was found after onion biscuit consumption. Alternative pathway for HCy degradation using betaine as methyl donor is probably a sole argument for reduced HCy value at the significantly reduced concentrations of the methionine, folic acid, cysteine and vitamin B6. Value of hs-CRP was non-significantly reduced after biscuit consumption.
  
  
  CONCLUSIONS
  The results of improved lipid profile, significantly reduced values of HCy and ADMA document a beneficial effect of cereal biscuit with selenized onion, curcuma and green tea in prevention of cardiovascular disease (Tab. 2, Ref. 19).
authors: Slovak Medical University, Bratislava, Slovakia.
authors: A
authors: A
authors: Madaric
authors: J
authors: J
authors: Kadrabova
authors: M
authors: M
authors: Krajcovicova-Kudlackova
authors: M
authors: M
authors: Valachovicova
authors: V
authors: V
authors: Spustova
authors: C
authors: C
authors: Mislanova
authors: I
authors: I
authors: Kajaba
authors: P
authors: P
authors: Blazicek
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D002318:Cardiovascular Diseases / Q000097:blood*; D002392:Catechin / Q000008:administration & dosage*; D003474:Curcumin / Q000008:administration & dosage*; D019587:Dietary Supplements; D055951:Functional Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D011794:Quercetin / Q000008:administration & dosage*; D012307:Risk Factors; D012643:Selenium / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D002392:Catechin; D011794:Quercetin; D012643:Selenium; D003474:Curcumin