title: Effect of 3,5-dicarbomethoxyphenylbiguanide on free radical homeostasis in rats with experimental myocarditis.
abstract: Administration of 3,5-dicarbomethoxyphenylbiguanide to rats with experimental epinephrine-induced myocarditis was followed by a decrease in activity of marker enzymes for cardiomyocyte cytolysis in the blood serum. This agent also decreased the intensity of free radical processes and had a normalizing effect on aconitase activity in the heart and blood serum of rats with myocarditis.
authors: Department of Medical Biochemistry and Microbiology, Voronezh State University, Russia.
authors: E S
authors: ES
authors: Tanigina
authors: A V
authors: AV
authors: Semenikhina
authors: T N
authors: TN
authors: Popova
authors: L V
authors: LV
authors: Matasova
authors: E D
authors: ED
authors: Kryl'skiy
mesh_terms: D000818:Animals; D001645:Biguanides / Q000737:chemistry* / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000737:chemistry* / Q000627:therapeutic use*; D005609:Free Radicals / Q000378:metabolism*; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D009205:Myocarditis / Q000188:drug therapy* / Q000378:metabolism*; D051381:Rats
chemical_list: D001645:Biguanides; D002316:Cardiotonic Agents; D005609:Free Radicals; C008846:phenyl biguanide