title: Depressive disorders and suicide: Epidemiology, risk factors, and burden.
abstract: The social and economic impact of mood disorders and suicide is extremely high and may be even higher in coming years, and yet, research in mental health is largely underfunded. This report summarizes the most recent data concerning the epidemiology and burden of depression and suicide, and underlines the most recent initiatives to identify the barriers to effective treatment and prevention of mood disorders. Global cooperation and networks of research networks are proposed. Progress in the understanding of the pathophysiology and subtypes of depression, technological advances, emphasis on early prediction of response and prevention, and a paradigm shift in drug development are crucial to overcome the current challenges posed by increasing rates of depression and suicide.
authors: Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain; Department of Psychiatry, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP), Universidad Autónoma de Madrid, Spain.
authors: Marta
authors: M
authors: Miret
authors: José Luis
authors: JL
authors: Ayuso-Mateos
authors: Jose
authors: J
authors: Sanchez-Moreno
authors: Eduard
authors: E
authors: Vieta
mesh_terms: D003866:Depressive Disorder / Q000191:economics / Q000453:epidemiology / Q000523:psychology; D005060:Europe / Q000453:epidemiology; D017048:Health Care Costs / Q000706:statistics & numerical data*; D006801:Humans; D007391:International Cooperation; D020380:Needs Assessment; D012307:Risk Factors; D013405:Suicide / Q000523:psychology*
keywords: Bipolar disorder; Burden; Depression; Drug development; Research; Suicide