title: [Mechanisms of resistance to crizotinib in patients with transforming EML4-ALK fusion gene].
authors: Hui-juan
authors: HJ
authors: Zhang
authors: Xiao-tong
authors: XT
authors: Zhang
authors: Li
authors: L
authors: Zhang
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D016227:Benzoquinones / Q000494:pharmacology; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000077547:Crizotinib; D019008:Drug Resistance, Neoplasm; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D047029:Lactams, Macrocyclic / Q000494:pharmacology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009154:Mutation; D015514:Oncogene Proteins, Fusion / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011720:Pyrazoles / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D014230:Triazoles / Q000494:pharmacology
chemical_list: D016227:Benzoquinones; C522504:EML4-ALK fusion protein, human; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; D015514:Oncogene Proteins, Fusion; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011725:Pyridines; C533237:STA 9090; D014230:Triazoles; C112765:tanespimycin; D000077547:Crizotinib