title: Celiac disease in a child with ulcerative colitis: a possible genetic association.
abstract: Celiac disease and inflammatory bowel disease including ulcerative colitis (UC) and Crohn's disease are both immune-mediated enteropathies. It is rare for both celiac disease and inflammatory bowel disease to occur together in an individual patient. This association has been reported in adults, however, very rarely in children. Here, we report an unusual case of an 8-year-old child with a history of anemia and failure to thrive who presented with bloody diarrhea. His evaluation showed anemia, elevated inflammatory markers, and positive celiac antibodies. Endoscopic evaluation revealed partial duodenal villous atrophy and pancolitis. He was diagnosed with celiac disease and UC and responded well to a gluten-free diet and steroid/mesalamine therapy. The patient's genetic testing revealed markers showing susceptibility for both celiac disease and UC. It is important to be aware of this association as both conditions can present with similar clinical features, however, require different therapeutic approaches.
authors: Section of Gastroenterology, Department of Pediatrics, Yale University, New Haven, CT, USA.
authors: Sam X
authors: SX
authors: Cheng
authors: Aileen
authors: A
authors: Raizner
authors: Uma P
authors: UP
authors: Phatak
authors: Judy H
authors: JH
authors: Cho
authors: Dinesh S
authors: DS
authors: Pashankar
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002446:Celiac Disease / Q000175:diagnosis / Q000178:diet therapy / Q000235:genetics*; D002648:Child; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D055050:Diet, Gluten-Free; D016099:Endoscopy, Gastrointestinal; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use; D010641:Phenotype; D011237:Predictive Value of Tests; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2 / Q000235:genetics*; D012698:Serologic Tests; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005765:Gastrointestinal Agents; D013256:Steroids; D019804:Mesalamine; C516649:PTPN2 protein, human; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2