title: Antimicrobial stewardship in pediatric care: strategies and future directions.
abstract: Antimicrobial stewardship programs (ASPs) are an effective strategy for improving the quality and safety of antimicrobial prescribing for hospitalized patients. Pediatric ASPs are in their early stages of development, and there are unique issues relevant to children. The imperative to ensure that antimicrobials are prescribed judiciously is highlighted by the ongoing epidemic increase in antimicrobial-resistant infections and the simultaneous decline in the rate of new drug development. In this review we describe the process of ASP development for pediatrics, review existing data regarding the impact of pediatric ASPs, and describe the priorities and challenges for ASP research including study design and appropriate end points.
authors: Section of Infectious Diseases, Department of Pediatrics, University of Missouri-Kansas City, Children's Mercy Hospitals & Clinics, Kansas City, Missouri 64108, USA. jnewland1@cmh.edu
authors: Jason G
authors: JG
authors: Newland
authors: Ritu
authors: R
authors: Banerjee
authors: Jeffrey S
authors: JS
authors: Gerber
authors: Adam L
authors: AL
authors: Hersh
authors: Leah
authors: L
authors: Steinke
authors: Scott J
authors: SJ
authors: Weissman
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002648:Child; D015195:Drug Design; D004352:Drug Resistance, Microbial; D023381:Endpoint Determination; D006761:Hospitals; D006801:Humans; D007239:Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000592:standards*; D011787:Quality of Health Care; D012107:Research Design
chemical_list: D000890:Anti-Infective Agents