title: Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation.
abstract: The purpose of this study was to assess the effects of berberine (BBR) on thermoregulation in mice exposed to hot (40°C) and cold (4°C) environmental conditions. Four groups of mice were assembled with three different dosages of BBR (0.2, 0.4, and 0.8 mg/kg) and normal saline (control). In room temperature, our largest dosage of BBR (0.8 mg/kg) can reduce rectal temperatures (Tc) of normal mice. In hot conditions, BBR can antagonize the increasing core body temperature and inhibit the expression of HSP70 and TNFα in mice; conversely, in cold conditions, BBR can antagonize the decreasing core body temperature and enhance the expression of TRPM8. This study demonstrates the dual ability of BBR in maintaining thermal balance, which is of great relevance to the regulation of HSP70, TNFα and TRPM8.
authors: Protein Science Laboratory of Ministry of Education, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China.
authors: Jing-Fei
authors: JF
authors: Jiang
authors: Yu-Gang
authors: YG
authors: Wang
authors: Jun
authors: J
authors: Hu
authors: Fan
authors: F
authors: Lei
authors: Michael M
authors: MM
authors: Kheir
authors: Xin-Pei
authors: XP
authors: Wang
authors: Yu-Shuang
authors: YS
authors: Chai
authors: Zhi-Yi
authors: ZY
authors: Yuan
authors: Xi
authors: X
authors: Lu
authors: Dong-Ming
authors: DM
authors: Xing
authors: Feng
authors: F
authors: Du
authors: Li-Jun
authors: LJ
authors: Du
mesh_terms: D000818:Animals; D001599:Berberine / Q000008:administration & dosage / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology*; D003080:Cold Temperature; D004562:Electrocardiography; D005786:Gene Expression Regulation / Q000187:drug effects; D018840:HSP70 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D006358:Hot Temperature; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000235:genetics; D050053:TRPM Cation Channels / Q000235:genetics / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D018840:HSP70 Heat-Shock Proteins; D050053:TRPM Cation Channels; C492297:TRPM8 protein, mouse; D014409:Tumor Necrosis Factor-alpha; D001599:Berberine