title: GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations.
abstract: This article describes the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to classifying the direction and strength of recommendations. The strength of a recommendation, separated into strong and weak, is defined as the extent to which one can be confident that the desirable effects of an intervention outweigh its undesirable effects. Alternative terms for a weak recommendation include conditional, discretionary, or qualified. The strength of a recommendation has specific implications for patients, the public, clinicians, and policy makers. Occasionally, guideline developers may choose to make "only-in-research" recommendations. Although panels may choose not to make recommendations, this choice leaves those looking for answers from guidelines without the guidance they are seeking. GRADE therefore encourages panels to, wherever possible, offer recommendations.
authors: Vanderbilt Evidence-based Practice Center, Vanderbilt University, #27166-719 Thompson Lane, Nashville, TN 37204-3195, USA. rafterl@mcmaster.ca
authors: Jeff
authors: J
authors: Andrews
authors: Gordon
authors: G
authors: Guyatt
authors: Andrew D
authors: AD
authors: Oxman
authors: Phil
authors: P
authors: Alderson
authors: Philipp
authors: P
authors: Dahm
authors: Yngve
authors: Y
authors: Falck-Ytter
authors: Mona
authors: M
authors: Nasser
authors: Joerg
authors: J
authors: Meerpohl
authors: Piet N
authors: PN
authors: Post
authors: Regina
authors: R
authors: Kunz
authors: Jan
authors: J
authors: Brozek
authors: Gunn
authors: G
authors: Vist
authors: David
authors: D
authors: Rind
authors: Elie A
authors: EA
authors: Akl
authors: Holger J
authors: HJ
authors: Schünemann
mesh_terms: D002985:Clinical Protocols / Q000592:standards*; D019317:Evidence-Based Medicine; D006801:Humans; D017410:Practice Guidelines as Topic / Q000592:standards*; D014481:United States