title: A new role for statins in sepsis.
abstract: Several studies have shown promising results regarding the use of statins as an adjunctive treatment for sepsis. Most of those studies were retrospective or observational in nature. The ASEPSIS trial has reported that the administration of atorvastatin reduced clinical progression of sepsis but did not improve mortality. These findings are promising and further multicenter trials are needed to confirm these outcomes and to establish whether this class of medications will offer utility in this regard.
authors: Jean-Sebastien
authors: JS
authors: Rachoin
authors: Elizabeth
authors: E
authors: Cerceo
authors: R Phillip
authors: RP
authors: Dellinger
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D011758:Pyrroles / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles