title: Aging is an important risk factor for peritoneal dialysis-associated peritonitis.
abstract: Peritonitis remains a leading complication of peritoneal dialysis (PD). The aim of this observational retrospective cohort study, conducted at our single center, was to determine the risk factors for peritonitis. A Cox proportional hazards model was used for the multivariate analysis. The event investigated was peritonitis, and the variables studied were sex, age, diabetes mellitus, use of statins, and several laboratory values including albumin and total cholesterol. All PD patients who visited our clinic from January 2005 to September 2011 and who had complete medical records for at least 3 years were included. Among the 82 patients who met the criteria (mean period of observation: 1086 +/- 752 days; mean age: 62.0 +/- 12.3 years), 47 had experienced at least 1 episode of peritonitis. Aging was a significant risk factor for peritonitis, with a relative risk of 1.04 per year (p = 0.014). In our study, aging--rather than diabetes mellitus, efficiency of PD, or nutrition status--was an important risk factor for PD-associated peritonitis. Poor PD technique because of advanced age might be one of the reasons for this result.
authors: Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
authors: Mika
authors: M
authors: Okayama
authors: Tsutomu
authors: T
authors: Inoue
authors: Yuka
authors: Y
authors: Nodaira
authors: Yumi
authors: Y
authors: Kimura
authors: Kanako
authors: K
authors: Nobe
authors: Takeru
authors: T
authors: Seto
authors: Keita
authors: K
authors: Sueyoshi
authors: Hiroshi
authors: H
authors: Takane
authors: Tsuneo
authors: T
authors: Takenaka
authors: Hirokazu
authors: H
authors: Okada
authors: Hiromichi
authors: H
authors: Suzuki
mesh_terms: D000367:Age Factors; D000368:Aged; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010538:Peritonitis / Q000209:etiology*; D016016:Proportional Hazards Models; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D012709:Serum Albumin