title: Effects of carnosine on polyamine levels in red blood cells of patients with hypertonic discirculatory encephalopathy.
abstract: The levels of polyamines (putrescine, spermine, spermidine) in erythrocytes from patients with hypertonic discirculatory encephalopathy are reduced (by 37, 45, and 50%, respectively) in comparison with the corresponding parameters in the control group. Addition of carnosine to the treatment protocol for chronic brain ischemia normalized the content of putrescine and spermine. The mechanisms of carnosine influence on polyamine metabolism are discussed: trapping of acrolein, end-product of polyamine oxidation, and compensation of NMDA-receptor excitotoxicity.
authors: Laboratory of Clinical and Experimental Neurochemistry, National Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
authors: M G
authors: MG
authors: Makletsova
authors: T N
authors: TN
authors: Fedorova
authors: M Yu
authors: MY
authors: Maksimova
authors: A A
authors: AA
authors: Boldyrev
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism; D002336:Carnosine / Q000494:pharmacology* / Q000627:therapeutic use; D002561:Cerebrovascular Disorders / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism
chemical_list: D011073:Polyamines; D013096:Spermine; D002336:Carnosine; D011700:Putrescine