title: Biodegradable conduit small gap tubulization for peripheral nerve mutilation: a substitute for traditional epineurial neurorrhaphy.
abstract: Nerve regeneration and re-innervation are usually difficult after peripheral nerve injury. Epineurium neurorrhaphy to recover the nerve continuity is the traditional choice of peripheral nerve mutilation without nerve defects, whereas the functional recovery remains quite unsatisfactory. Based on previous research in SD rats and Rhesus Monkeys, a multiple centers clinical trial about biodegradable conduit small gap tubulization for peripheral nerve mutilation to substitute traditional epineurial neurorrhaphy was carried out. Herein, the authors reviewed the literature that focused on peripheral nerve injury and possible clinical application, and confirmed the clinical possibilities of biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation. The biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation may be a revolutionary innovation in peripheral nerve injury and repair field.
authors: Department of Trauma & Orthopedics, Peking University People's Hospital, Beijing, China. zhangpeixun@bjmu.edu.cn
authors: Peixun
authors: P
authors: Zhang
authors: Na
authors: N
authors: Han
authors: Tianbing
authors: T
authors: Wang
authors: Feng
authors: F
authors: Xue
authors: Yuhui
authors: Y
authors: Kou
authors: Yanhua
authors: Y
authors: Wang
authors: Xiaofeng
authors: X
authors: Yin
authors: Laijin
authors: L
authors: Lu
authors: Guanglei
authors: G
authors: Tian
authors: Xu
authors: X
authors: Gong
authors: Shanlin
authors: S
authors: Chen
authors: Yu
authors: Y
authors: Dang
authors: Jianping
authors: J
authors: Peng
authors: Baoguo
authors: B
authors: Jiang
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D006801:Humans; D008253:Macaca mulatta; D009416:Nerve Regeneration; D059348:Peripheral Nerve Injuries / Q000628:therapy*; D010525:Peripheral Nerves / Q000503:physiopathology*; D051381:Rats; D020127:Recovery of Function; D012584:Sciatic Nerve / Q000293:injuries
keywords: Biodegradable Conduit; Epineurial Neurorrhaphy; Peripheral Nerve Mutilation; Small Gap; Tubulization