title: Sequential mediastinal lymphadenectomy of an unknown primary tumor.
abstract: An 83-year-old woman was admitted for lower mediastinal lymphadenopathy, detected by computed tomography; preoperative examinations did not detect a primary lesion. Fifteen months after tumor resection, a new mediastinal lymphadenopathy located 4 cm from the site of the first lesion was resected. Histopathologic and immunohistochemical examinations of both tumors revealed metastatic, poorly differentiated, adenocarcinomas with identical findings; however, the primary site could not be identified based on these examinations. The patient has remained disease-free for 23 months since the last surgery. Thus, sequential resections of metachronous mediastinal lymph node metastases from an unknown primary cancer yielded beneficial disease control.
authors: Department of Respiratory Surgery, National Health Organization Kure Medical Center, Hiroshima, Japan. haradah@kure-nh.go.jp
authors: Hiroaki
authors: H
authors: Harada
authors: Yoshinori
authors: Y
authors: Yamashita
authors: Kazuya
authors: K
authors: Kuraoka
authors: Kiyomi
authors: K
authors: Taniyama
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery*; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods*; D008207:Lymphatic Metastasis; D008482:Mediastinum; D009382:Neoplasms, Unknown Primary / Q000473:pathology*