title: Macular hole after intravitreal bevacizumab injection for choroidal neovascularisation.
abstract: OBJECTIVE
  The aim of this study was to report a patient who developed a full-thickness macular hole following intravitreal bevacizumab injection.
  
  
  METHODS
  A 78-year-old patient diagnosed with choroidal neovascularisation (CNV) was treated with intravitreal bevacizumab injection.
  
  
  RESULTS
  On the first follow-up visit, a decrease in visual acuity was seen and a small full-thickness macular hole with complete resolution of subretinal fluid was observed in optical coherence tomography (OCT). A second intravitreal injection of bevacizumab was performed. At the subsequent visit, a serious loss of visual acuity and limited regression in choroidal neovascularisation was seen. The OCT showed a larger full-thickness macular hole.
  
  
  CONCLUSIONS
  This case demonstrates that intravitreal bevacizumab injection might be responsible for the development of a macular hole. Clinicians should be cautious that a macular hole may be a complication of intravitreal bevacizumab injection.
authors: Department of Ophthalmology, School of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey. ha_tufan@hotmail.com.
authors: Hasan Ali
authors: HA
authors: Tufan
authors: Baran
authors: B
authors: Gencer
authors: Selcuk
authors: S
authors: Kara
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D000068258:Bevacizumab; D020256:Choroidal Neovascularization / Q000188:drug therapy*; D006801:Humans; D058449:Intravitreal Injections; D008266:Macula Lutea / Q000293:injuries*; D008297:Male; D012167:Retinal Perforations / Q000139:chemically induced*; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab
keywords: bevacizumab; intravitreal injection; macular hole