title: Platelet factor-4 (CXCL4/PF-4): an angiostatic chemokine for cancer therapy.
abstract: Platelet factor-4 (CXCL4/PF-4) is the first chemokine identified to have several biological functions. Notably, CXCL4/PF-4 inhibits endothelial cell proliferation and migration, leading to suppression of angiogenesis. Since angiogenesis is essential for the growth of most primary tumors and their subsequent metastases, it is a target for cancer therapy; due to its multiple functions, CXCL4/PF-4 is a potential clinical anti-tumor agent. This report reviews the mechanisms of CXCL4/PF-4 angiostatic activity, including interference with angiogenic growth factors bFGF-2 and VEGF165, activation of CXCR3B, interactions with integrins, interference with cell cycle, interactions with factors such as VEGF121 and CXCL8/IL-8, and derived molecules of CXCL4/PF-4 with angiostatic and anti-tumoral activities in different models in vivo or in vitro.
authors: Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 30072, China.
authors: Zhe
authors: Z
authors: Wang
authors: He
authors: H
authors: Huang
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D010978:Platelet Factor 4 / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D020533:Angiogenesis Inhibitors; D010978:Platelet Factor 4