title: TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.).
abstract: The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in ∼20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of platelet-derived growth factor -induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor p21(WAF1/CIP1). Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4.
authors: Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors: Y
authors: Y
authors: Liu
authors: Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors: R
authors: R
authors: Raheja
authors: Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors: N
authors: N
authors: Yeh
authors: Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors: D
authors: D
authors: Ciznadija
authors: Human Oncology and Pathogenesis, New York, NY, USA.
authors: A M
authors: AM
authors: Pedraza
authors: Cancer Biology, New York, NY, USA.
authors: T
authors: T
authors: Ozawa
authors: Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors: E
authors: E
authors: Hukkelhoven
authors: Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors: H
authors: H
authors: Erdjument-Bromage
authors: Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors: P
authors: P
authors: Tempst
authors: Computational Biology. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors: N P
authors: NP
authors: Gauthier
authors: Human Oncology and Pathogenesis, New York, NY, USA.
authors: C
authors: C
authors: Brennan
authors: Cancer Biology, New York, NY, USA.
authors: E C
authors: EC
authors: Holland
authors: Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors: A
authors: A
authors: Koff
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D002461:Cell Line, Transformed; D045744:Cell Line, Tumor; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015151:Immunoblotting; D019656:Loss of Heterozygosity; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D011485:Protein Binding; D034622:RNA Interference; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; D012333:RNA, Messenger; C426543:TRIM3 protein, human; C586979:TRIM3 protein, mouse; D025521:Tumor Suppressor Proteins