title: The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland.
abstract: BACKGROUND
  The G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer in North America (about 20-fold). The geographical and ethnic extent of this recurrent allele has not yet been determined.
  
  
  METHODS
  We assayed for the presence of the G84E mutation in 3,515 prostate cancer patients and 2,604 controls from Poland and estimated the odds ratio for prostate cancer associated with the allele.
  
  
  RESULTS
  The G84E mutation was detected in 3 of 2,604 (0.1%) individuals from the general population in Poland and in 20 of 3,515 (0.6%) men with prostate cancer (Odds ratio [OR] = 5.0; 95% CI: 1.5-16.7; P = 0.008). The allele was present in 4 of 416 (1.0%) men with familial prostate cancer (OR = 8.4, 95% CI: 1.9-37.7; P = 0.005).
  
  
  CONCLUSIONS
  The G84E mutation predisposes to prostate cancer in Poland, but accounts for only a small proportion of cases. We expect that the G84E founder mutation might be present in other Slavic populations.
authors: International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors: Wojciech
authors: W
authors: Kluźniak
authors: Dominika
authors: D
authors: Wokołorczyk
authors: Aniruddh
authors: A
authors: Kashyap
authors: Anna
authors: A
authors: Jakubowska
authors: Jacek
authors: J
authors: Gronwald
authors: Tomasz
authors: T
authors: Huzarski
authors: Tomasz
authors: T
authors: Byrski
authors: Tadeusz
authors: T
authors: Dębniak
authors: Adam
authors: A
authors: Gołąb
authors: Bartłomiej
authors: B
authors: Gliniewicz
authors: Andrzej
authors: A
authors: Sikorski
authors: Jerzy
authors: J
authors: Switała
authors: Tomasz
authors: T
authors: Borkowski
authors: Andrzej
authors: A
authors: Borkowski
authors: Andrzej
authors: A
authors: Antczak
authors: Lukasz
authors: L
authors: Wojnar
authors: Jacek
authors: J
authors: Przybyła
authors: Marek
authors: M
authors: Sosnowski
authors: Bartosz
authors: B
authors: Małkiewicz
authors: Romuald
authors: R
authors: Zdrojowy
authors: Paulina
authors: P
authors: Sikorska-Radek
authors: Józef
authors: J
authors: Matych
authors: Jacek
authors: J
authors: Wilkosz
authors: Waldemar
authors: W
authors: Różański
authors: Jacek
authors: J
authors: Kiś
authors: Krzysztof
authors: K
authors: Bar
authors: Piotr
authors: P
authors: Bryniarski
authors: Andrzej
authors: A
authors: Paradysz
authors: Konrad
authors: K
authors: Jersak
authors: Jerzy
authors: J
authors: Niemirowicz
authors: Piotr
authors: P
authors: Słupski
authors: Piotr
authors: P
authors: Jarzemski
authors: Michał
authors: M
authors: Skrzypczyk
authors: Jakub
authors: J
authors: Dobruch
authors: Paweł
authors: P
authors: Domagała
authors: Mohammad R
authors: MR
authors: Akbari
authors: Jan
authors: J
authors: Lubiński
authors: Steven A
authors: SA
authors: Narod
authors: Cezary
authors: C
authors: Cybulski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010375:Pedigree; D017354:Point Mutation / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D011471:Prostatic Neoplasms / Q000208:ethnology* / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data
chemical_list: C484414:HOXB13 protein, human; D018398:Homeodomain Proteins