title: CCR9 inhibition does not interfere with the development of immune tolerance to oral antigens.
abstract: Recent literature indicates that mice deficient in the chemokine receptor CCR9 (CCR9(-/-) mice) are unable to generate oral tolerance. The present report describes how such inability can be overcome by increasing the dose of oral antigen. Pharmacological inhibition of CCR9 did not affect the generation of oral tolerance, regardless of antigen dose. These results highlight the inadequacy of genetic deletion of CCR9 when predicting the effects of pharmacological CCR9 inhibition on intestinal biology.
authors: ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, CA 94043, United States. mwalters@chemocentryx.com
authors: Matthew J
authors: MJ
authors: Walters
authors: Karen
authors: K
authors: Ebsworth
authors: Timothy J
authors: TJ
authors: Sullivan
authors: Penglie
authors: P
authors: Zhang
authors: Jay P
authors: JP
authors: Powers
authors: Juan C
authors: JC
authors: Jaen
authors: Thomas J
authors: TJ
authors: Schall
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D010047:Ovalbumin / Q000276:immunology; D054388:Receptors, CCR / Q000037:antagonists & inhibitors* / Q000235:genetics
chemical_list: D000941:Antigens; C119309:CC chemokine receptor 9; D054388:Receptors, CCR; D010047:Ovalbumin