title: Applications for nitric oxide in halting proliferation of tumor cells.
abstract: Tumor resistance to cytotoxic therapeutics coupled with dose-limiting toxicity is a serious hurdle in the field of medical oncology. In the face of this obstacle, nitric oxide has emerged as a powerful adjuvant for the hypersensitization of tumors to more traditional chemo- and radio-therapeutics. Furthermore, emerging evidence indicates that nitric oxide donors have the potential to function independently in the clinical management of cancer. Herein, we discuss the role of nitric oxide in cancer and the potential for nitric oxide donors to support conventional therapeutics.
authors: Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1052, USA.
authors: Melissa M
authors: MM
authors: Reynolds
authors: Scott D
authors: SD
authors: Witzeling
authors: Vinod B
authors: VB
authors: Damodaran
authors: Tysha N
authors: TN
authors: Medeiros
authors: Ryan D
authors: RD
authors: Knodle
authors: Melissa A
authors: MA
authors: Edwards
authors: Pashayar P
authors: PP
authors: Lookian
authors: Mark A
authors: MA
authors: Brown
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D020030:Nitric Oxide Donors; D009569:Nitric Oxide