title: Cardioprotective properties of dimethyl sulfoxide during global ischemia-reperfusion of isolated rat heart.
abstract: Cardioprotective properties of dimethyl sulfoxide (DMSO) were studied in the isolated rat heart model. Intraperitoneal administration of DMSO to animals for 3 days before the experiment, but not addition of DMSO to the perfusate, reduced infarction size. Both intraperitoneal and intracoronary administration of DMSO reduced the severity of postischemic left-ventricular dysfunction.
authors: V. A. Almazov Federal Heart, Blood, and Endocrinology Center, St. Petersburg, Russia. jury.v.dmitriev@gmail.com
authors: Yu V
authors: YV
authors: Dmitriev
authors: S M
authors: SM
authors: Minasian
authors: E A
authors: EA
authors: Demchenko
authors: M M
authors: MM
authors: Galagudza
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006321:Heart / Q000503:physiopathology; D006352:Heart Ventricles / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000188:drug therapy*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D002316:Cardiotonic Agents; D004121:Dimethyl Sulfoxide