title: An efficient and facile synthesis of 3-amino-5-chromenyl-butenolides from 3-formyl chromone, dialkyl acetylenedicarboxylate, and primary amines.
abstract: A three-component reaction of 3-formyl chromones, dialkyl acetylenedicarboxylate, and isocyanides in the presence of POCl(3) was used as a highly efficient and practical approach for the synthesis of 3-amino-5-chromenyl-butenolides. High yields and high bond forming efficiency, and simple operations are the advantages of this method. Graphical abstract.
authors: Peptide Chemistry Research Center, KN Toosi University of Technology, Tehran, Iran. balalaie@kntu.ac.ir
authors: Saeed
authors: S
authors: Balalaie
authors: Morteza
authors: M
authors: Ashouriha
authors: Frank
authors: F
authors: Rominger
authors: Hamid Reza
authors: HR
authors: Bijanzadeh
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002867:Chromones / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000588:Amines; D002867:Chromones; D003486:Cyanides; D005231:Fatty Acids, Unsaturated; C024060:2-butynedioic acid; C004511:butenolide; D015107:4-Butyrolactone