title: Alternatively activated macrophages in spinal cord injury and remission: another mechanism for repair?
abstract: Tissues within the central nervous system (CNS) have generally been regarded as immunologically privileged. However, in recent decades, it has been shown that immune reactions in the CNS continuously occur via various types of inflammation following autoimmune diseases and mechanical insults such as spinal cord injury (SCI). Among the various inflammatory cells associated with CNS disease, activated macrophages are classically known to induce detrimental consequences that are mediated by the secretion of pro-inflammatory molecules. Alternatively activated macrophages have recently been shown to modulate various types of CNS inflammation, including SCI. This review summarizes the potential roles of alternatively activated macrophages in the course of CNS inflammation in rodent SCI models.
authors: Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 690-756, Republic of Korea. shint@jejunu.ac.kr
authors: Taekyun
authors: T
authors: Shin
authors: Meejung
authors: M
authors: Ahn
authors: Changjong
authors: C
authors: Moon
authors: Seungjoon
authors: S
authors: Kim
authors: Ki-Bum
authors: KB
authors: Sim
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008262:Macrophage Activation / Q000276:immunology*; D009416:Nerve Regeneration; D012074:Remission Induction; D013119:Spinal Cord Injuries / Q000276:immunology* / Q000473:pathology*; D014945:Wound Healing