title: [Therapeutic efficacy of allogeneic hematopoietic stem cell transplantation in children with chronic myelogenous leukemia].
abstract: OBJECTIVE
  To investigate the therapeutic efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with chronic myelogenous leukemia (CML), and to analyze the possible prognostic factors.
  
  
  METHODS
  The clinical data of 20 children with CML who had received allo-HSCT was analyzed retrospectively to investigate possible prognostic factors, including age, sex, interval between diagnosis and transplantation, HLA matching between donors and recipients, illness status on transplantation and acute and chronic graft-versus-host disease (GVHD).
  
  
  RESULTS
  At the end of follow-up, 13 of the 20 treated children had disease-free survival (DFS) and the rest (7 cases) died. Four died of severe acute GVHD, two of chronic GVHD and its complications, and one of relapse after transplantation. The three-year DFS was (64.6±1.1%). As shown by the univariate analysis, age was the most important prognostic factor in children with CML who had received allo-HSCT (P<0.05), and in children over 10 years, the prognosis was poor. No other of the above factors had a significant impact on prognosis (P>0.05). The multivariate logistic regression analysis also confirmed age as the only prognostic factor (P<0.01). Severe acute and/or chronic GVHD was the most important cause of patient death. 10/10 HLA-matched donors could improve the transplantation outcome.
  
  
  CONCLUSIONS
  Allo-HSCT is an effective treatment for children with CML. To improve the prognosis and treatment outcome, children with CML aged over 10 years should receive allo-HSCT as early as possible. 10/10 HLA-matched donors are preferred in allo-HSCT and GVHD should be prevented.
authors: Department of Hematology/Oncology, Shanghai Jiaotong University, Shanghai, China. jiang_hua18@yahoo.com.cn
authors: Hua
authors: H
authors: Jiang
authors: Wen-Ting
authors: WT
authors: Hu
authors: Jing
authors: J
authors: Chen
authors: Chang-Ying
authors: CY
authors: Luo
authors: Jian-Min
authors: JM
authors: Wang
authors: Min
authors: M
authors: Zhou
authors: Qi-Dong
authors: QD
authors: Ye
authors: Yan-Jing
authors: YJ
authors: Tang
authors: Cheng-Juan
authors: CJ
authors: Luo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006650:Histocompatibility Testing; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000401:mortality / Q000601:surgery*; D016015:Logistic Models; D008297:Male; D012189:Retrospective Studies; D014184:Transplantation, Homologous