title: (18)F-florbetaben Aβ imaging in mild cognitive impairment.
abstract: BACKGROUND
  (18)F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Aβ) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).
  
  
  METHODS
  Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education.
  
  
  RESULTS
  High Aβ burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Aβ burden.
  
  
  CONCLUSIONS
  Higher Aβ deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.
authors: Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia.
authors: Kevin
authors: K
authors: Ong
authors: Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Department of Medicine, University of Melbourne, Parkville, VIC 3010, Australia ; Mental Health Research Institute, 155 Oak Street, Parkville, VIC 3052, Australia.
authors: Victor L
authors: VL
authors: Villemagne
authors: Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Centre for Research on Aging, Health, and Wellbeing, 63 Eggleston Road, The Australian National University, Acton, ACT 2600, Australia.
authors: Alex
authors: A
authors: Bahar-Fuchs
authors: Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Mental Health Research Institute, 155 Oak Street, Parkville, VIC 3052, Australia.
authors: Fiona
authors: F
authors: Lamb
authors: Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia.
authors: Gaël
authors: G
authors: Chételat
authors: CSIRO Preventative Health National Research Flagship, The Australian e-Health Research Centre - BioMedIA, Herston, QLD 4029, Australia.
authors: Parnesh
authors: P
authors: Raniga
authors: Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia.
authors: Rachel S
authors: RS
authors: Mulligan
authors: CSIRO Preventative Health National Research Flagship, The Australian e-Health Research Centre - BioMedIA, Herston, QLD 4029, Australia.
authors: Olivier
authors: O
authors: Salvado
authors: Bayer Pharma AG, Müllerstraße 178, 13353 Berlin, Germany.
authors: Barbara
authors: B
authors: Putz
authors: Bayer Pharma AG, Müllerstraße 178, 13353 Berlin, Germany.
authors: Katrin
authors: K
authors: Roth
authors: Mental Health Research Institute, 155 Oak Street, Parkville, VIC 3052, Australia.
authors: Colin L
authors: CL
authors: Masters
authors: Bayer Pharma AG, Müllerstraße 178, 13353 Berlin, Germany.
authors: Cornelia B
authors: CB
authors: Reininger
authors: Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Department of Medicine, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Christopher C
authors: CC
authors: Rowe