title: Computational peptidology: a new and promising approach to therapeutic peptide design.
abstract: The recent focus on protein-protein interaction networks has increasingly been shifted towards the disruption of protein complexes, which either are mediated by the binding of a globular domain in one protein to a short peptide stretch in another, or involve flat, large, and hydrophobic interfaces that classical small-molecule agents are not always ideally suited. Rational design of therapeutic peptides with high affinity targeting such interactions has emerged as a new and promising tool in discovery of potential drug candidates against associated diseases. The design is commonly based on bioinformatics methods or molecular modeling techniques, indirectly exploiting structure-activity relationship at the level of peptide sequence or directly deriving lead entities from protein complex architecture. Here, a newly rising subfield called computational peptidology that focuses on the use of computational and theoretical approaches to treat peptide-related problems is comprehensively reviewed on the design and discovery of peptide agents targeting protein-protein interactions. We address a systematic discussion on several representative cases in which the computational peptidology is successfully employed to develop peptide therapeutics. Besides, some problems and pitfalls accompanied with the current use of computational methods in peptide modeling and design are also present.
authors: Center of Bioinformatics (COBI), School of Life Science and Technology, University of Electronic Science and Technology of China (UESTC), Chengdu 610054, China. p_zhou@uestc.edu.cn
authors: P
authors: P
authors: Zhou
authors: C
authors: C
authors: Wang
authors: Y
authors: Y
authors: Ren
authors: C
authors: C
authors: Yang
authors: F
authors: F
authors: Tian
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods; D015195:Drug Design; D006801:Humans; D062105:Molecular Docking Simulation; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D060066:Protein Interaction Maps / Q000187:drug effects*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D010455:Peptides; D011506:Proteins