title: The bone tissue compatibility of a new Ti35Nb2Ta3Zr alloy with a low             Young's modulus.
abstract: Titanium (Ti) alloys of the β-type are highly attractive metallic materials             for biomedical applications due to their low elastic modulus, high corrosion resistance             and notable biocompatibility. A new β-type Ti35Nb2Ta3Zr alloy with a low Young's             modulus of approximately 48 GPa was previously fabricated. In the present study,             the biocompatibility of this alloy was evaluated. In an in vitro assay, the Ti35Nb2Ta3Zr             alloy did not markedly affect the adhesion of MG63 osteoblast cells, but it increased             their proliferation, alkaline phosphatase (ALP) activity, calcium deposition and             mRNA expression of osteogenic genes (i.e., ALP, osteocalcin, osteopontin). In             an in vivo study, no marked histological differences were observed between the             new bone formed on the surface of Ti35Nb2Ta3Zr and that formed on the surface             of control Ti6Al4V rods placed in the medullary canal of rabbit femurs. Additionally,             no significant differences were observed in the failure load of Ti35Nb2Ta3Zr and             Ti6Al4V in pull-out tests. In conclusion, the Ti35Nb2Ta3Zr alloy with a lower             elastic modulus closer to that of human bone has significant bone tissue compatibility             equal to that of Ti6Al4V, which has been widely used in orthopedic applications.
authors: Department of Orthopedics, The Sixth Affiliated People's Hospital, Medical School of Shanghai Jiao Tong University, Shanghai, PR China.
authors: Yongyuan
authors: Y
authors: Guo
authors: Desheng
authors: D
authors: Chen
authors: Mengqi
authors: M
authors: Cheng
authors: Weijie
authors: W
authors: Lu
authors: Liqiang
authors: L
authors: Wang
authors: Xianlong
authors: X
authors: Zhang
mesh_terms: D000469:Alkaline Phosphatase / Q000235:genetics / Q000378:metabolism; D000497:Alloys / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001842:Bone and Bones; D002118:Calcium / Q000378:metabolism; D002448:Cell Adhesion; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival / Q000187:drug effects; D055119:Elastic Modulus; D006801:Humans; D008297:Male; D008422:Materials Testing; D009532:Nickel / Q000737:chemistry; D010006:Osteoblasts / Q000166:cytology; D015675:Osteocalcin / Q000235:genetics; D053495:Osteopontin / Q000235:genetics; D012516:Osteosarcoma; D019736:Prostheses and Implants; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D011817:Rabbits; D013635:Tantalum; D014025:Titanium / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D012333:RNA, Messenger; C000606736:Ti35Nb2Ta3Zr alloy; D015675:Osteocalcin; D053495:Osteopontin; C031462:titanium alloy (TiAl6V4); D013635:Tantalum; D009532:Nickel; D015040:Zirconium; D014025:Titanium; D000469:Alkaline Phosphatase; D002118:Calcium