title: Functional and developmental significance of amplitude variance asymmetry in the BOLD resting-state signal.
abstract: It is known that the brain's resting-state activity (RSA) is organized in low frequency oscillations that drive network connectivity. Recent research has also shown that elements of RSA described by high-frequency and nonoscillatory properties are non-random and functionally relevant. Motivated by this research, we investigated nonoscillatory aspects of the blood-oxygen-level-dependent (BOLD) RSA using a novel method for characterizing subtle fluctuation dynamics. The metric that we develop quantifies the relative variance of the amplitude of local-maxima and local-minima in a BOLD time course (amplitude variance asymmetry; AVA). This metric reveals new properties of RSA activity, without relying on connectivity as a descriptive tool. We applied the AVA analysis to data from 3 different participant groups (2 adults, 1 child) collected from 3 different centers. The analyses show that AVA patterns a) identify 3 types of RSA profiles in adults' sensory systems b) differ in topology and pattern of dynamics in adults and children, and c) are stable across magnetic resonance scanners. Furthermore, children with higher IQ demonstrated more adult-like AVA patterns. These findings indicate that AVA reflects important and novel dimensions of brain development and RSA.
authors: Center for Mind/Brain Sciences (CIMeC), University of Trento, I-38060 Mattarello (TN), Italy and.
authors: Ben
authors: B
authors: Davis
authors: Jorge
authors: J
authors: Jovicich
authors: Vittorio
authors: V
authors: Iacovella
authors: Uri
authors: U
authors: Hasson
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001289:Attention Deficit Disorder with Hyperactivity / Q000473:pathology / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply* / Q000254:growth & development / Q000473:pathology; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D015331:Cohort Studies; D066264:Datasets as Topic; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D012146:Rest / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: amplitude asymmetry; development; nonlinear; nonstationary; resting-state