title: Radiolabeled iron oxide nanoparticles as dual-modality SPECT/MRI and PET/MRI agents.
abstract: Dual-modality contrast agents, such as radiolabeled nanoparticles, are promising candidates for a number of diagnostic applications, since they combine the advantages of two different imaging modalities, namely SPECT or PET imaging with MR imaging. The benefit of such a combination is to more accurately interpret disease and abnormalities in vivo, by exploiting the advantages of each imaging technique, i.e. high sensitivity for SPECT/PET, high resolution anatomical information for MRI. In this review article, we provide an overview of recent findings in the synthesis, evaluation and application of radiolabeled iron oxide nanoparticles as dual-modality SPECT/MRI and PET/MRI imaging probes.
authors: National Center for Scientific Research Demokritos, Patriarchou Grigoriou and Neapoleos Street, 15310 Aghia Paraskevi, Athens, Greece. bouzioti@rrp.demokritos.gr
authors: Penelope
authors: P
authors: Bouziotis
authors: Dimitrios
authors: D
authors: Psimadas
authors: Theodoros
authors: T
authors: Tsotakos
authors: Dimosthenis
authors: D
authors: Stamopoulos
authors: Charalampos
authors: C
authors: Tsoukalas
mesh_terms: D000906:Antibodies / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry / Q000627:therapeutic use; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D007553:Isotope Labeling; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D010455:Peptides / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods; D011868:Radioisotopes / Q000737:chemistry; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods
chemical_list: D000906:Antibodies; D000970:Antineoplastic Agents; D003287:Contrast Media; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D010455:Peptides; D011868:Radioisotopes; C000499:ferric oxide