title: Dementia in 2012: Further insights into Alzheimer disease pathogenesis.
abstract: In 2012, studies of autosomal dominant Alzheimer disease (AD), late-onset AD, and a rare genetic mutation of amyloid precursor protein provided support for the critical role of amyloid in AD pathogenesis. Increasing evidence implicated cell-to-cell transmission in the spread of tau and amyloid, highlighting novel targets for therapeutic intervention.
authors: Center for Imaging of Neurodegenerative Diseases, Department of Radiology, San Francisco VA Medical Center/University of California San Francisco, 4150 Clement Street (114M), San Francisco CA, 94121 USA. michael.weiner@ucsf.edu
authors: Michael W
authors: MW
authors: Weiner
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000502:physiology; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D017326:Clinical Trials, Phase III as Topic; D003704:Dementia / Q000235:genetics / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D009154:Mutation / Q000235:genetics / Q000502:physiology; D017211:Treatment Failure; D016875:tau Proteins / Q000235:genetics / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D000911:Antibodies, Monoclonal; D016875:tau Proteins