title: Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy.
abstract: The rapid development of nanotechnology holds great promise for revolutionizing the current landscape of tumor drug delivery. However, one of the biggest challenges is developing a simple nanocarrier platform to co-deliver various therapeutic agents. Here, a strategy for fabricating nanocarriers with many desirable features is demonstrated. The resulting nanoparticles achieve both high antitumor efficacy and effective inhibition of tumor metastasis with minimal side effects.
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology (NCNST), Zhongguancun, Beijing, P R China.
authors: Hai
authors: H
authors: Wang
authors: Yan
authors: Y
authors: Wu
authors: Ruifang
authors: R
authors: Zhao
authors: Guangjun
authors: G
authors: Nie
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry*; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008546:Melanoma, Experimental / Q000473:pathology; D051379:Mice; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D017239:Paclitaxel / Q000008:administration & dosage; D011092:Polyethylene Glycols / Q000737:chemistry; D011099:Polyglutamic Acid / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; C579712:methoxypoly(ethylene glycol)-block-poly(glutamic acid); D011099:Polyglutamic Acid; D011092:Polyethylene Glycols; D004317:Doxorubicin; D016650:Fluorescein-5-isothiocyanate; D017239:Paclitaxel