title: Predictive utility of NT-pro BNP for infarct size and left ventricle function after acute myocardial infarction in long-term follow-up.
abstract: OBJECTIVE
  The aim of the study was to evaluate the utility of N-terminal pro-B-type natriuretic peptide (NT-pro BNP, pg/ml) assessment to predict infarct size and left ventricle function after ST-segment elevation myocardial infarction (STEMI) at long-term follow-up.
  
  
  METHODS
  In 45 patients with first STEMI less than 3 hours from symptom onset treated with mechanical reperfusion NT-pro BNP was assessed early (at admission) and at 6 months. Cardiac magnetic resonance (CMR) parameters (delayed enhancement infarct size (IS, %), left ventricular end-diastolic (LVEDVI, ml/m2) and end-systolic (LVESVI, ml/m2) volume indexes) were assessed at 6 months.
  
  
  RESULTS
  No significant correlation was found between baseline NT-pro BNP assessment and IS and left ventricle function after 6 months. There was a significant correlation between 6-month NT-pro BNP and IS (r=0.65, p<0.001) and left ventricle remodeling at 6 months (LVEDVI, r=0.53, p=0.001; LVESVI, r=0.51, p=0.002).
  
  
  CONCLUSIONS
  Assessment of NT-pro BNP level 6 months after STEMI remains a good indicator of infarct size and left ventricle function at long-term follow-up.
authors: Department of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
authors: Paweł
authors: P
authors: Kleczyński
authors: Jacek
authors: J
authors: Legutko
authors: Tomasz
authors: T
authors: Rakowski
authors: Artur
authors: A
authors: Dziewierz
authors: Zbigniew
authors: Z
authors: Siudak
authors: Joanna
authors: J
authors: Zdzienicka
authors: Agata
authors: A
authors: Brzozowska-Czarnek
authors: Andrzej
authors: A
authors: Surdacki
authors: Jacek S
authors: JS
authors: Dubiel
authors: Dariusz
authors: D
authors: Dudek
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008163:Luminescent Measurements; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D012307:Risk Factors; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain