title: A review on the mechanism of sore throat in tonsillitis.
abstract: BACKGROUND
  Sore throat is a common condition associated with acute upper respiratory tract infection, and recurrent episodes of infection may result in chronic tonsillitis. The current UK and USA guidelines for tonsillectomy use the incidence of sore throat episodes as an indication for surgery. However, the mechanism of sore throat is poorly described in the literature.
  
  
  OBJECTIVE
  This review will provide basic information for the clinician regarding: the causes, pathophysiology and neurophysiology of sore throat; the mechanism of inflammation; and the role of transient receptor potential ion channels as nociceptors involved in sore throat. The review will present new ideas on the mechanism of ice therapy as an analgesic for post-tonsillectomy pain, and the role of vanilloid and cold receptors.
authors: Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Wales, UK. bathalas@cardiff.ac.uk
authors: S
authors: S
authors: Bathala
authors: R
authors: R
authors: Eccles
mesh_terms: D002908:Chronic Disease; D006801:Humans; D007053:Ice; D007249:Inflammation / Q000150:complications* / Q000601:surgery; D010146:Pain / Q000188:drug therapy; D014066:Palatine Tonsil / Q000473:pathology; D010612:Pharyngitis / Q000209:etiology* / Q000601:surgery; D050916:TRPV Cation Channels / Q000502:physiology; D014068:Tonsillectomy; D014069:Tonsillitis / Q000209:etiology* / Q000601:surgery
chemical_list: D007053:Ice; D050916:TRPV Cation Channels