title: Trends of mortality and cause of death among HIV-infected patients in Korea, 1990-2011.
abstract: Although a decrease in acquired immunodeficiency syndrome (AIDS)-related mortality has been documented in highly active antiretroviral therapy (HAART) era, there are no published data comparing specific causes of death between pre-HAART and HAART era in Korea. Mortality and cause of death were analyzed in three treatment periods; pre-HAART (1990-1997), early-HAART (1998-2001), and late-HAART period (2002-2011). The patients were retrospectively classified according to the treatment period in which they were recruited. Although mortality rate per 100 person-year declined from 8.7 in pre-HAART to 4.9 in late-HAART period, the proportion of deaths within 3 months of initial visit to study hospital significantly increased from 15.9% in pre-HAART to 55.1% in late-HAART period (P < 0.001). Overall, 59% of deaths were attributable to AIDS-related conditions, and Pneumocystis pneumonia (PCP) was the most common cause of death (20.3%). The proportion of PCP as cause of death significantly increased from 8.7% in pre-HAART to 31.8% in late-HAART period (P < 0.001). Despite of significant improvement of survival, there was still a high risk of early death in patients presenting in HAART era, mainly due to late human immunodeficiency virus (HIV) diagnosis and late presentation to care.
authors: Deparment of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. mdssampak@yahoo.co.kr
authors: Sun Hee
authors: SH
authors: Lee
authors: Kye-Hyung
authors: KH
authors: Kim
authors: Seung Geun
authors: SG
authors: Lee
authors: Dong Hwan
authors: DH
authors: Chen
authors: Dong Sik
authors: DS
authors: Jung
authors: Chi Sook
authors: CS
authors: Moon
authors: Ji Young
authors: JY
authors: Park
authors: Joo Seop
authors: JS
authors: Chung
authors: Ihm Soo
authors: IS
authors: Kwak
authors: Goon Jae
authors: GJ
authors: Cho
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D002423:Cause of Death / Q000639:trends*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000401:mortality*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000401:mortality; D056910:Republic of Korea; D012189:Retrospective Studies
keywords: Antiretroviral Therapy; Cause of Death; HIV; Mortality