title: [Ostemalacia due to a tumor secreting FGF-23].
abstract: A case of oncogenic osteomalacia in a 50-year-old male is here presented. He suffered severe bone pain and marked muscular weakness of 4 years' duration. There were several vertebral deformities in the thoracic spine, bilateral fractures of the iliopubic branches, another fracture in the left ischiopubic branch, and a Looser's zone in the right proximal tibia. An octreotide-Tc scan allowed to identify a small tumor in the posterior aspect of the right knee. It was surgically removed. Microscopically, it was a phosphaturic mesenchymal tumor-mixed connective tissue (PMT-MCT). Expression of FGF-23 was documented by immune-peroxidase staining. There was rapid improvement, with consolidation of the pelvic fractures and the tibial pseudo-fracture. The laboratory values returned to normal.
authors: Centro de Endocrinología, Rosario, Brazil. asanchez@cimero.org.ar
authors: Ariel
authors: A
authors: Sánchez
authors: Alejandro
authors: A
authors: Castiglioni
authors: Nicolás
authors: N
authors: Cóccaro
authors: Roberto
authors: R
authors: Silva
authors: Eduardo
authors: E
authors: Bobrovsky
authors: Rosa M A
authors: RM
authors: Moysés
authors: Fabiana
authors: F
authors: Graciolli
mesh_terms: D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000209:etiology; D007717:Knee; D008297:Male; D008637:Mesenchymoma / Q000378:metabolism*; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000209:etiology*; D010018:Osteomalacia; D010257:Paraneoplastic Syndromes
chemical_list: C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23