title: Mega-trials for blockbusters.
authors: Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA. jioannid@stanford.edu
authors: John P A
authors: JP
authors: Ioannidis
mesh_terms: D003365:Costs and Cost Analysis; D004345:Drug Industry / Q000191:economics; D004358:Drug Therapy; D023381:Endpoint Determination; D006801:Humans; D009026:Mortality; D015337:Multicenter Studies as Topic; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic / Q000191:economics* / Q000706:statistics & numerical data; D012107:Research Design; D012109:Research Support as Topic; D018401:Sample Size; D016896:Treatment Outcome