title: Analytical specificity and sensitivity of the APTIMA Combo 2 and APTIMA GC assays for detection of commensal Neisseria species and Neisseria gonorrhoeae on the Gen-Probe Panther instrument.
abstract: Genetic detection of Neisseria gonorrhoeae is replacing culture for increased diagnostic sensitivity. Specificity of several nucleic acid amplification tests is suboptimal. Herein, the Gen-Probe APTIMA Combo 2 and APTIMA GC assays had 100% specificity and 100% sensitivity after confirmatory testing, when testing 298 isolates of nongonococcal Neisseria and related species and 205 gonococcal isolates.
authors: WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for Pathogenic Neisseria, Örebro, Sweden.
authors: Daniel
authors: D
authors: Golparian
authors: Sepehr N
authors: SN
authors: Tabrizi
authors: Magnus
authors: M
authors: Unemo
mesh_terms: D001431:Bacteriological Techniques / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000295:instrumentation / Q000379:methods*; D009343:Neisseria / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D009344:Neisseria gonorrhoeae / Q000235:genetics / Q000302:isolation & purification; D016870:Neisseriaceae Infections / Q000175:diagnosis* / Q000382:microbiology; D021141:Nucleic Acid Amplification Techniques / Q000295:instrumentation / Q000379:methods*; D012680:Sensitivity and Specificity