title: Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.
abstract: Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)--a selective serotonin reuptake inhibitor--inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A and HEV-C or human rhinovirus A or B. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound.
authors: Department of Infectious Diseases and Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
authors: Rachel
authors: R
authors: Ulferts
authors: Lonneke
authors: L
authors: van der Linden
authors: Hendrik Jan
authors: HJ
authors: Thibaut
authors: Kjerstin H W
authors: KH
authors: Lanke
authors: Pieter
authors: P
authors: Leyssen
authors: Bruno
authors: B
authors: Coutard
authors: Armando M
authors: AM
authors: De Palma
authors: Bruno
authors: B
authors: Canard
authors: Johan
authors: J
authors: Neyts
authors: Frank J M
authors: FJ
authors: van Kuppeveld
mesh_terms: D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D029822:Enterovirus B, Human / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D030016:Enterovirus D, Human / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D005473:Fluoxetine / Q000494:pharmacology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors; D017361:Viral Nonstructural Proteins; C076023:2C protein, viral