title: Consumption of polyphenol-rich juar tea increases endothelium-bound extracellular superoxide dismutase levels in men with metabolic syndrome: link with LDL oxidizability.
abstract: Endothelium-bound extracellular superoxide dismutase (eEC-SOD), a major antioxidative enzyme in the vasculature, is involved in anti-atherogenesis by inhibiting low-density lipoprotein (LDL) oxidation. The objective was to investigate whether the polyphenol-rich juar tea had beneficial effects on LDL oxidation and eEC-SOD levels in patients with metabolic syndrome (MetS). A total of 20 men with MetS participated in a randomized cross-over trial, comparing consumption of five cups/day of juar tea with that of a polyphenol-poor tea, barley tea, for 4 weeks. Although there was no change in LDL oxidizability after consumption of either tea, juar tea significantly increased eEC-SOD levels by 16% (p < 0.05), whereas barley tea significantly decreased levels by 15% (p < 0.05). It is noteworthy that the changes in eEC-SOD were positively associated with those in LDL oxidizability after tea consumption (r(2) = 0.11, p < 0.05). Tea polyphenols may provide anti-atherosclerotic effects by inhibiting LDL oxidation through EC-SOD bound to the endothelium.
authors: Division of Anti-aging and Vascular Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors: Harumi
authors: H
authors: Uto-Kondo
authors: Makoto
authors: M
authors: Ayaori
authors: Yoshimi
authors: Y
authors: Kishimoto
authors: Tetsuo
authors: T
authors: Adachi
authors: Shunichi
authors: S
authors: Takiguchi
authors: Emi
authors: E
authors: Yakushiji
authors: Makoto
authors: M
authors: Sasaki
authors: Tomohiro
authors: T
authors: Komatsu
authors: Kazuo
authors: K
authors: Kondo
authors: Katsunori
authors: K
authors: Ikewaki
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D050197:Atherosclerosis / Q000378:metabolism / Q000517:prevention & control; D028241:Camellia sinensis / Q000737:chemistry*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D001467:Hordeum; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism; D010084:Oxidation-Reduction; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D059808:Polyphenols / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism*; D013662:Tea / Q000737:chemistry
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D059808:Polyphenols; D013662:Tea; D013482:Superoxide Dismutase