title: Short-term and long-term outcomes for patients with autoimmune pancreatitis after pancreatectomy: a multi-institutional study.
abstract: BACKGROUND
  Autoimmune pancreatitis (AIP) is a rare subtype of chronic pancreatitis that may mimic adenocarcinoma of the pancreas. The aim of this study was to evaluate the short-term and long-term outcomes of pancreatectomy for patients with AIP.
  
  
  METHODS
  In this multi-institutional study, we identified all patients who underwent pancreatectomy for AIP from 1986 to 2011. AIP was confirmed by pathology review. Clinical presentation, operative details, and postoperative outcomes were analyzed.
  
  
  RESULTS
  Seventy-four patients (median age, 60 years; 69 % male) with AIP underwent pancreatectomy. The main indication for operation was concern for malignancy (n = 59, 80 %). No patients were found to have pancreatic adenocarcinoma on final pathology. Major complications occurred in ten (14 %) patients, with one perioperative death (1 %). Clinically relevant (grade B/C) pancreatic fistulae occurred in two patients. No patients required reoperation for AIP and 11 (17 %) patients developed recurrent AIP.
  
  
  CONCLUSIONS
  Although we do not advocate pancreatectomy for AIP, strong suspicion of malignancy may require an operation in selected patients. For patients with AIP, pancreatectomy resulted in few pancreatic fistulae, a low rate of re-intervention, and a 17 % recurrence rate.
authors: Department of General Surgery, Wake Forest Baptist Health, Medical Center Boulevard, Winston-Salem, NC 27157, USA. cjclark@wakehealth.edu
authors: Clancy J
authors: CJ
authors: Clark
authors: Vicente
authors: V
authors: Morales-Oyarvide
authors: Victor
authors: V
authors: Zaydfudim
authors: John
authors: J
authors: Stauffer
authors: Vikram
authors: V
authors: Deshpande
authors: Thomas C
authors: TC
authors: Smyrk
authors: Suresh T
authors: ST
authors: Chari
authors: Carlos
authors: C
authors: Fernández-del Castillo
authors: Michael B
authors: MB
authors: Farnell
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010195:Pancreatitis / Q000601:surgery*; D011183:Postoperative Complications; D012008:Recurrence; D016896:Treatment Outcome