title: Cytokine concentrations and regulatory T cells in living donor and deceased donor liver transplant recipients.
abstract: Outcomes of pediatric liver transplantation have constantly improved in the last decade. Living-related liver transplantation does not seem to improve long-term outcomes following liver transplantation, but few studies have evaluated immunological parameters of the alloimmune response after living vs. deceased donor organ transplantation. We analyzed numbers of regulatory T cells, lymphocyte subsets, and serum cytokine concentrations in 12 pediatric recipients of living-related liver transplants and in 28 pediatric recipients of deceased donor organs during their annual follow-ups. Transplant recipients who underwent living donor organ transplantation had significantly higher numbers of regulatory T cells and IL-4 serum concentrations than recipients of deceased donor organs; both of these factors are associated with beneficial outcomes and transplantation tolerance. Living-related liver transplantation may have potentially beneficial immunological aspects, although long-term outcomes do not seem to be better in recipients of living donor organs than in recipients of deceased donor organs. Further studies are needed to compare immunological aspects of the two transplant procedures.
authors: Pediatric Hepatology and Liver Transplantation, Transplantation Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. a.richter@uke.de
authors: Andrea
authors: A
authors: Briem-Richter
authors: Alexander
authors: A
authors: Leuschner
authors: Friedrich
authors: F
authors: Haag
authors: Enke
authors: E
authors: Grabhorn
authors: Rainer
authors: R
authors: Ganschow
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D015847:Interleukin-4 / Q000097:blood; D008107:Liver Diseases / Q000601:surgery*; D016031:Liver Transplantation / Q000276:immunology*; D019520:Living Donors; D008297:Male; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; C508598:IL4 protein, human; D015847:Interleukin-4