title: Fine-granularity functional interaction signatures for characterization of brain conditions.
abstract: In the human brain, functional activity occurs at multiple spatial scales. Current studies on functional brain networks and their alterations in brain diseases via resting-state functional magnetic resonance imaging (rs-fMRI) are generally either at local scale (regionally confined analysis and inter-regional functional connectivity analysis) or at global scale (graph theoretic analysis). In contrast, inferring functional interaction at fine-granularity sub-network scale has not been adequately explored yet. Here our hypothesis is that functional interaction measured at fine-granularity sub-network scale can provide new insight into the neural mechanisms of neurological and psychological conditions, thus offering complementary information for healthy and diseased population classification. In this paper, we derived fine-granularity functional interaction (FGFI) signatures in subjects with Mild Cognitive Impairment (MCI) and Schizophrenia by diffusion tensor imaging (DTI) and rs-fMRI, and used patient-control classification experiments to evaluate the distinctiveness of the derived FGFI features. Our experimental results have shown that the FGFI features alone can achieve comparable classification performance compared with the commonly used inter-regional connectivity features. However, the classification performance can be substantially improved when FGFI features and inter-regional connectivity features are integrated, suggesting the complementary information achieved from the FGFI signatures.
authors: School of Automation, Northwestern Polytechnical University, Xi'an, China.
authors: Xintao
authors: X
authors: Hu
authors: Dajiang
authors: D
authors: Zhu
authors: Peili
authors: P
authors: Lv
authors: Kaiming
authors: K
authors: Li
authors: Junwei
authors: J
authors: Han
authors: Lihong
authors: L
authors: Wang
authors: Dinggang
authors: D
authors: Shen
authors: Lei
authors: L
authors: Guo
authors: Tianming
authors: T
authors: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D001931:Brain Mapping; D060825:Cognitive Dysfunction / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009415:Nerve Net / Q000098:blood supply / Q000473:pathology*; D009434:Neural Pathways / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D012559:Schizophrenia / Q000473:pathology*
chemical_list: D010100:Oxygen