title: Direct targeting of proteins from the cytosol to organelles: the ER versus endosymbiotic organelles.
abstract: In eukaryotic cells consisting of many different types of organelles, targeting of organellar proteins is one of the most fundamental cellular processes. Proteins belonging to the endoplasmic reticulum (ER), chloroplasts and mitochondria are targeted individually from the cytosol to their cognate organelles. As the targeting to these organelles occurs in the cytosol during or after translation, the most crucial aspect is how specific targeting to these three organelles can be achieved without interfering with other targeting pathways. For these organelles, multiple mechanisms are used for targeting proteins, but the exact mechanism used depends on the type of protein and organelle, the location of targeting signals in the protein and the location of the protein in the organelle. In this review, we discuss the various mechanisms involved in protein targeting to the ER, chloroplasts and mitochondria, and how the targeting specificity is determined for these organelles in plant cells.
authors: Divisions of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea.
authors: Dae Heon
authors: DH
authors: Kim
authors: Inhwan
authors: I
authors: Hwang
mesh_terms: D000818:Animals; D002736:Chloroplasts / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D021381:Protein Transport; D013559:Symbiosis