title: Effect of somatostatin on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in the neurons of rat brain.
abstract: We studied the effect of somatostatin on presinaptic NMDA receptors and postsinaptic GABA, NMDA, and AMPA receptors in rat brain. It was shown that somatostatin inhibits NMDA-induced (45)Ca(2+) uptake into synaptosomes isolated from rat brain cortex (IC50=2.8×10(-11) M). Somatostatin potentiates AMPA receptors and inhibits hippocampal NMDA receptors in the entire range of examined concentrations (10(-14)-10(-7) M); it also potentiates or inhibits GABA receptor currents in a concentration-dependent manner. Our results suggest that somatostatin modulates the function of ionotropic glutamate and GABA receptors and is involved in cognitive and neurodegenerative processes in the mammalian brain.
authors: Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy Sciences, Chernogolovka, Moscow Region, Russia. grigor@ipac.ac.ru
authors: V V
authors: VV
authors: Grigoriev
authors: L N
authors: LN
authors: Petrova
authors: A V
authors: AV
authors: Gabrelian
authors: V L
authors: VL
authors: Zamoyski
authors: T P
authors: TP
authors: Serkova
authors: S O
authors: SO
authors: Bachurin
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D053497:Corticotropin-Like Intermediate Lobe Peptide / Q000378:metabolism; D004357:Drug Synergism; D017136:Ion Transport / Q000187:drug effects*; D007608:Kainic Acid / Q000494:pharmacology; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D018408:Patch-Clamp Techniques; D051381:Rats; D018091:Receptors, AMPA / Q000378:metabolism*; D018079:Receptors, GABA / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D018091:Receptors, AMPA; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; D013004:Somatostatin; D053497:Corticotropin-Like Intermediate Lobe Peptide; D005680:gamma-Aminobutyric Acid; D016202:N-Methylaspartate; D007608:Kainic Acid; D002118:Calcium