title: Copper-catalyzed direct secondary and tertiary C-H alkylation of azoles through a heteroarene-amine-aldehyde/ketone coupling reaction.
abstract: Coupling the strangers: A copper-catalyzed three-component heteroarene-amine-aldehyde/ketone coupling affords a novel approach to the hitherto difficult direct secondary/tertiary C-H alkylation of azoles. This simple method allows the facile installation of diversely substituted, branched and nitrogen-containing alkyl or alkaloid side chains on the azole moiety by using readily available starting materials.
authors: Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven, Belgium.
authors: Dipak D
authors: DD
authors: Vachhani
authors: Abhishek
authors: A
authors: Sharma
authors: Erik
authors: E
authors: Van der Eycken
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D001393:Azoles / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000447:Aldehydes; D000588:Amines; D001393:Azoles; D007659:Ketones; D003300:Copper