title: Applications of thiyl radical cyclizations for the synthesis of thiosugars.
abstract: The use of intramolecular thiyl radical cyclizations for the synthesis of thiosugars has been investigated, and a new free-radical-based methodology for the synthesis of biologically important thiosugars has been developed. The methodology is mild and proceeds via either 6-endo or 5-exo cyclization to furnish the thiosugar ring. This represents the first examples of thiyl radical cyclization being applied to the synthesis of thiosugars.
authors: School of Chemistry, Trinity College Dublin, Trinity Biomedical Sciences Insitute, 152-160 Pearse Street, Dublin 2, Ireland.
authors: Aoife
authors: A
authors: Malone
authors: Eoin M
authors: EM
authors: Scanlan
mesh_terms: D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism; D013457:Sulfur Compounds / Q000737:chemistry*; D054330:Thiosugars / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D013457:Sulfur Compounds; D054330:Thiosugars