title: Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
abstract: The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the discovery of key compounds 10j and 17h.
authors: Department of Chemical Research, Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA. pauline.ting@merck.com
authors: Pauline C
authors: PC
authors: Ting
authors: Joe F
authors: JF
authors: Lee
authors: Nicolas
authors: N
authors: Zorn
authors: Hyunjin M
authors: HM
authors: Kim
authors: Robert G
authors: RG
authors: Aslanian
authors: Mingxiang
authors: M
authors: Lin
authors: Michelle
authors: M
authors: Smith
authors: Scott S
authors: SS
authors: Walker
authors: John
authors: J
authors: Cook
authors: Margaret
authors: M
authors: Van Heek
authors: Jean
authors: J
authors: Lachowicz
mesh_terms: D000577:Amides / Q000494:pharmacology*; D000818:Animals; D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D011725:Pyridines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D004791:Enzyme Inhibitors; D011725:Pyridines; C494881:DGAT1 protein, human; D051048:Diacylglycerol O-Acyltransferase