title: Interferon γ in patients with HIV/AIDS and suspicion or latent tuberculosis infection.
abstract: OBJECTIVE
  To assess the usefulness of IGRA test (QuantiFERON(®)-Cell mediated immune) compared with the tuberculin skin test.
  
  
  METHODS
  A cross-sectional study was carried out in Mexico, 25 infected patients with HIV-AIDS and the suspicion or with latent tuberculous infection (LTBI) who were >18 years of age and without treatment for tuberculosis (TB), were enrolled in the study.
  
  
  RESULTS
  Median cluster of differentiation (CD4) count was 364 cells/μ L and median HIV viral load was 50 copies/mL. Overall, 20 patients (80%) had at least one positive diagnostic test for LTBI: four (16%) had a positive tuberculin skin test and 19 (76%), a positive QuantiFERON(®)-tuberculosis.
  
  
  CONCLUSIONS
  No agreement is found between the two diagnostic tests: k = -0.004, 95% confidence interval (-0.2219, 0.2210). Additional longitudinal studies among HIV-infected populations with high prevalence of TB are needed to further assess the usefulness of IGRAs in this patient population.
authors: Unidad de Investigación en Inmunología e Infectología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social Mexico City, Mexico. gelorriaga@webtelmex.net.mx
authors: Guadalupe
authors: G
authors: García-Elorriaga
authors: Mayté
authors: M
authors: Martínez-Velázquez
authors: Verónica
authors: V
authors: Gaona-Flores
authors: Guillermo
authors: G
authors: del Rey-Pineda
authors: César
authors: C
authors: González-Bonilla
mesh_terms: D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis* / Q000276:immunology / Q000378:metabolism; D059425:Interferon-gamma Release Tests / Q000706:statistics & numerical data*; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000276:immunology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D014374:Tuberculin Test / Q000706:statistics & numerical data; D019562:Viral Load
chemical_list: D007371:Interferon-gamma