title: Non-hodgkin B-cell lymphoma of the ovary in a child with Ataxia-telangiectasia.
abstract: BACKGROUND
  Ataxia-telangiectasia is a multisystem, life-limiting, recessively inherited genetic disorder caused by mutations in the Ataxia-telangiectasia mutated gene. It is characterized by the onset of changes in neurological and immunological development, organ maturation in childhood, as well as a high incidence of malignancies.
  
  
  METHODS
  We describe a case of an 11-year-old girl with a history of progressive ataxia and new finding of bilateral pelvic masses. Given an elevated alpha-fetoprotein, the pre-operative working diagnosis was a malignant germ cell tumor. Final ovarian pathology revealed a non-Hodgkin B-cell lymphoma with Burkitt-like morphology.
  
  
  CONCLUSIONS
  We present the first case of a primary ovarian non-Hodgkin B-cell lymphoma in a child with Ataxia-telangiectasia.
authors: Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME, USA.
authors: C S
authors: CS
authors: Danby
authors: L
authors: L
authors: Allen
authors: M D
authors: MD
authors: Moharir
authors: S
authors: S
authors: Weitzman
authors: T
authors: T
authors: Dumont
mesh_terms: D001260:Ataxia Telangiectasia / Q000150:complications* / Q000235:genetics; D002648:Child; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D058994:Salpingectomy; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography