title: Clinical and epidemiological study on severe fever with thrombocytopenia syndrome in Yiyuan County, Shandong Province, China.
abstract: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China. Polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect SFTS virus (SFTSV) and Anaplasma phagocytophilum in previous clinically diagnosed human anaplasmosis patients and SFTS patients. A serosurvey for SFTSV infection was also conducted on healthy persons and animals in Yiyuan County in Shandong Province of China. Among 21 patients SFTSV was detected in 17 (81%) however A. phagocytophilum was not detected in any of the patients. The seroprevalence rate of IgG antibody to SFTSV antigens was 1.3% (1 of 78) in healthy persons, 95% (19 of 20) in goats, 50% (1 of 2) in dogs, 0% in cattle (0 of 21), and rats (Rattus norvegicus) (0 of 35). The conclusion of this study was that co-infection of SFTSV and A. phagocytophilum are rare in SFTS patients and goats might play an important role in transmission of SFTSV.
authors: Zibo Municipal Center for Disease Control and Prevention, Zibo City, Shandong Province, China. cuifeng@126.com
authors: Feng
authors: F
authors: Cui
authors: Hai-Xia
authors: HX
authors: Cao
authors: Ling
authors: L
authors: Wang
authors: Shou-Feng
authors: SF
authors: Zhang
authors: Shu-Jun
authors: SJ
authors: Ding
authors: Xue-Jie
authors: XJ
authors: Yu
authors: Hao
authors: H
authors: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D041081:Anaplasma phagocytophilum / Q000302:isolation & purification*; D000818:Animals; D000914:Antibodies, Viral; D002044:Bunyaviridae Infections / Q000150:complications / Q000453:epidemiology*; D060085:Coinfection / Q000453:epidemiology / Q000382:microbiology; D021821:Communicable Diseases, Emerging / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D016873:Ehrlichiosis / Q000150:complications / Q000453:epidemiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008297:Male; D008875:Middle Aged; D016856:Phlebovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G