title: Plasma atrial natriuretic peptide is an early diagnosis and disease severity marker of myxomatous mitral valve disease in dogs.
abstract: The aim of this study was to retrospectively assess the clinical usefulness of plasma atrial natriuretic peptide (ANP) concentrations for determining the severity of myxomatous mitral valve disease (MMVD) in dogs. Plasma ANP levels were found to be significantly higher in dogs with MMVD compared to healthy dogs, and plasma ANP levels increased significantly in dogs with progressive heart failure. In dogs with MMVD, stepwise regression analysis revealed that the left atrium/aorta ratio and fractional shortening could be used to predict the plasma ANP concentration. These results indicated that plasma ANP rose with an increase in the volume overload of the left side of the heart. Plasma ANP discriminated cardiomegaly from non-cardiomegaly caused by asymptomatic MMVD. We conclude, therefore, that plasma ANP concentrations may be a clinically useful tool for early diagnosis of asymptomatic MMVD in dogs.
authors: Veterinary Cardiovascular Medicine and Surgery Unit, Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Japan.
authors: Takashi
authors: T
authors: Ebisawa
authors: Yuzuru
authors: Y
authors: Ohta
authors: Marina
authors: M
authors: Funayama
authors: Shigeki
authors: S
authors: Yamano
authors: Masashi
authors: M
authors: Mizuno
authors: Takeshi
authors: T
authors: Mizuno
authors: Arane
authors: A
authors: Kasuya
authors: Tamotsu
authors: T
authors: Sawada
authors: Junseok
authors: J
authors: Lee
authors: Takahiro
authors: T
authors: Mizukoshi
authors: Masami
authors: M
authors: Uechi
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis*; D004285:Dogs; D015150:Echocardiography, Doppler / Q000662:veterinary; D005260:Female; D008297:Male; D008944:Mitral Valve Insufficiency / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D009320:Atrial Natriuretic Factor