title: [Association between recurrent miscarriages and insulin resistance: a meta analysis].
abstract: OBJECTIVE
  To evaluate the association between recurrent miscarriages and insulin resistance.
  
  
  METHODS
  The case-control studies on the association between recurrent spontaneous abortion and insulin resistance from June 1996 to April 2012 were collected from Medline, Elsevier, Chinese Journal Full-text Database, Chinese Biological Medicine Database, data base of Wanfang, Springer link and EMBASE. RevMan 5.1 software was used for Meta analysis.
  
  
  RESULTS
  According to the included criteria, 7 clinical trials were finally selected. Total 467 cases with recurrent pregnancy loss were enrolled in study group, while 413 women with no history of abnormal pregnancies were enrolled in control group. No significant difference was found in average age and body mass index between the two groups (P > 0.05). Meta analysis results showed that the level of fasting glucose was no statistical difference between study group and control group (WMD = 2.27, 95%CI: -1.11 to 5.65, P > 0.05); fasting insulin level was higher 2.05 mU/L in study group than that of in control group, the difference was statistically significant (WMD = 2.05, 95%CI: 1.03 to 3.08, P < 0.01). Case number of study group on Homa-insulin resistance > 4.5 was more than that of control group (OR = 3.36, 95%CI: 1.72 to 6.57, P < 0.01). Case number of study group on glucose/insulin ratio < 4.5 was more than that of the control group, statistical difference was found (OR = 3.37, 95%CI: 1.90 to 5.99, P < 0.01).
  
  
  CONCLUSIONS
  Insulin resistance is associated with the susceptibility to recurrent miscarriages, and it may contribute to the occurrence of recurrent miscarriages.
authors: Reproductive Medical Center, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors: Ze-lian
authors: ZL
authors: Li
authors: Hui-fen
authors: HF
authors: Xiang
authors: Ling-hui
authors: LH
authors: Cheng
authors: Yun-xia
authors: YX
authors: Cao
authors: Zhao-lian
authors: ZL
authors: Wei
authors: Cheng
authors: C
authors: Liu
authors: Jing-jing
authors: JJ
authors: Hu
authors: Fa-ming
authors: FM
authors: Pan
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000503:physiopathology; D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D016022:Case-Control Studies; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin