title: Endocrine sequelae and metabolic syndrome in adult long-term survivors of childhood acute myeloid leukemia.
abstract: This study focuses on the effect of chemotherapy on endocrinopathies and the metabolic syndrome in adult survivors of childhood acute myeloid leukemia (AML). Endocrine function and metabolic syndrome were evaluated in 12 AML survivors, treated with chemotherapy, and in 9 survivors of myeloid leukemias treated with stem cell transplantation (SCT), after a median follow-up time of 20 years (range 9-31). In survivors treated with chemotherapy, no endocrinopathies or metabolic syndrome were present, although AMH and Inhibin B levels tended to be lower than in controls. In SCT survivors, pituitary deficiencies and metabolic syndrome were more frequent.
authors: Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam, The Netherlands. k.blijdorp@erasmusmc.nl
authors: Karin
authors: K
authors: Blijdorp
authors: Marjolein
authors: M
authors: van Waas
authors: Aart-Jan
authors: AJ
authors: van der Lely
authors: Rob
authors: R
authors: Pieters
authors: Marry
authors: M
authors: van den Heuvel-Eibrink
authors: Sebastian
authors: S
authors: Neggers
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015519:Bone Density; D002648:Child; D050171:Dyslipidemias / Q000150:complications; D004700:Endocrine System Diseases / Q000150:complications*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D017741:Survivors