title: Platelet-rich plasma to improve the bio-functionality of biomaterials.
abstract: Growth factors and cytokines are active players in controlling the different stages of wound healing and tissue regeneration. Recent trends in personalized regenerative medicine involve using patient's own platelet-rich plasma for stimulating wound healing and tissue regeneration. This technology provides a complex cocktail of growth factors and even a fibrin scaffold with multiple biologic effects. In the last few years, an increasing number of studies provide evidence of the potential of combining platelet-rich plasma with different biomaterials in order to improve their properties, including handling, administration, bioactivity, and level of osseointegration, among others. In this review, we discuss the use of platelet-rich plasma as an alternative, easy, cost-effective, and controllable strategy for the release of high concentrations of many endogenous growth factors. Additionally, we provide an overview of the current progress and future directions of research combining different types of biomaterials with platelet-rich plasma in tissue engineering and regenerative medicine.
authors: BTI Biotechnology Institute, Vitoria, Spain.
authors: Eduardo
authors: E
authors: Anitua
authors: Ricardo
authors: R
authors: Tejero
authors: Mohammad H
authors: MH
authors: Alkhraisat
authors: Gorka
authors: G
authors: Orive
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D053657:Platelet-Rich Plasma; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins