title: Clinical and research markers of oxidative stress in chronic kidney disease.
abstract: BACKGROUND
  Kidney-related pathologies have increasing prevalence rates, produce a considerable financial burden, and are characterized by elevated levels of oxidative stress (OS).
  
  
  OBJECTIVE
  This review examines relationships between chronic kidney disease (CKD) and markers of OS and antioxidant status (AS).
  
  
  METHODS
  A systematic review of MEDLINE-indexed clinical trials, randomized controlled trials and comparative studies that examined OS and AS was performed.
  
  
  CONCLUSIONS
  Several markers emerged as well-suited indicators of OS and AS in CKD: malondialdehyde, F2-isoprostanes, lipid hydroperoxides, asymmetric dimethylarginine, 8-oxo-7,8-dihydro-2'-deoxyguanosine, protein carbonyls, advanced oxidation protein products and glutathione-related activity.
authors: Clinical Biochemistry Laboratory, Institute for Health and Social Science Research, Central Queensland University, Rockhampton, QLD, Australia.
authors: Patrick Steven
authors: PS
authors: Tucker
authors: Vincent James
authors: VJ
authors: Dalbo
authors: Thin
authors: T
authors: Han
authors: Michael Ian
authors: MI
authors: Kingsley
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000097:blood; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002986:Clinical Trials as Topic; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D028441:F2-Isoprostanes / Q000097:blood; D005978:Glutathione / Q000097:blood; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D050050:Protein Carbonylation; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000175:diagnosis / Q000473:pathology / Q000652:urine*
chemical_list: D062107:Advanced Oxidation Protein Products; D015415:Biomarkers; D028441:F2-Isoprostanes; D008054:Lipid Peroxides; D008315:Malondialdehyde; C018524:N,N-dimethylarginine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D001120:Arginine; D003849:Deoxyguanosine; D005978:Glutathione