title: Influence of extremely low-frequency magnetic field on the activity of antioxidant enzymes during skin wound healing in rats.
abstract: The aim of this study was to evaluate the activity of the antioxidant enzymes mitochondrial and cytosolic superoxide dismutase (EC 1.15.1.1), glutathione peroxidase (POX, EC 1.11.1.9) and glutathione S-transferase (EC 3.1.2.7), as well as the concentration of malone dialdehyde (MDA), as an indicator of lipid peroxidation rate in the liver tissue homogenates and blood serum of male rats exposed to extremely low-frequency magnetic field (ELF-MF) in order to improve the healing process of an experimental cut wound on the back of each animal. The exposure to ELF-MF with frequency 40 Hz and magnetic flux density 10 mT induced an increase in POX serum activity and a decrease in MDA contents in the liver tissue, which suggests the inhibition of phospholipid peroxidation and subsequent stabilization of cellular membranes, as a result of ELF-MF action. Based on the results obtained, it seems that ELF-MF could be a useful supplement in the complex treatment of prolonged wound healing, due to the activation of endogenous enzymatic antioxidant system.
authors: Department of General Surgery, District Hospital , Strzelce Opolskie , Poland.
authors: Marek
authors: M
authors: Glinka
authors: Aleksander
authors: A
authors: Sieroń
authors: Ewa
authors: E
authors: Birkner
authors: Grzegorz
authors: G
authors: Cieślar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D015227:Lipid Peroxidation; D008099:Liver / Q000166:cytology / Q000378:metabolism; D060526:Magnetic Fields; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin; D013482:Superoxide Dismutase / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase