title: Lysogenic Streptococcus suis isolate SS2-4 containing prophage SMP showed increased mortality in zebra fish compared to the wild-type isolate.
abstract: Streptococcus suis (S. suis) infection is considered to be a major problem in the swine industry worldwide. Based on the capsular type, 33 serotypes of S. suis have been described, with serotype 2 (SS2) being the most frequently isolated from diseased piglets. Little is known, however, about the pathogenesis and virulence factors of S. suis. Research on bacteriophages highlights a new area in S. suis research. A S. suis serotype 2 bacteriophage, designated SMP, has been previously isolated in our laboratory. Here, we selected a lysogenic isolate in which the SMP phage was integrated into the chromosome of strain SS2-4. Compared to the wild-type isolate, the lysogenic strain showed increased mortality in zebra fish. Moreover the sensitivity of the lysogenic strain to lysozyme was seven times higher than that of the wild-type.
authors: Key Lab Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
authors: Fang
authors: F
authors: Tang
authors: Wei
authors: W
authors: Zhang
authors: Chengping
authors: C
authors: Lu
mesh_terms: D000818:Animals; D008242:Lysogeny / Q000235:genetics; D039002:Prophages / Q000235:genetics / Q000472:pathogenicity*; D012703:Serotyping; D013290:Streptococcal Infections / Q000235:genetics* / Q000401:mortality / Q000662:veterinary / Q000821:virology; D017011:Streptococcus suis / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology / Q000821:virology; D013552:Swine / Q000235:genetics / Q000821:virology; D013553:Swine Diseases / Q000821:virology; D015027:Zebrafish / Q000382:microbiology / Q000502:physiology