title: Pharmaceutical solid dispersion technology: a strategy to improve dissolution of poorly water-soluble drugs.
abstract: Oral bioavailability is the major problem when a poorly water-soluble active agent is delivered via oral route. To overcome such problems, solid dispersion systems have been demonstrated in literature to enhance the dissolution property of poorly water-soluble drugs. In the present review, the important aspects to be considered during preparation of solid dispersion systems viz., properties of polymer and preparation techniques of solid dispersion which affect the dissolution rate are discussed. Formulation and evaluation techniques for solid dispersions have been described. The final section of article highlights the recent patents and studies related to solid dispersion systems.
authors: Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Delhi- Roorkee Highway, NH-58, Baghpat Crossing, Meerut-250005, U.P. India. shobhitkmr87@gmail.com
authors: Shobhit
authors: S
authors: Kumar
authors: Satish K
authors: SK
authors: Gupta
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D016503:Drug Delivery Systems; D006801:Humans; D010330:Patents as Topic; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D011108:Polymers