title: [Influence of the ecological group on the in vitro antifungal susceptibility of dermatophytic fungi].
abstract: BACKGROUND
  Dermatophytes can be divided into geophilic (soil), zoophilic (animals) and anthropophilic (humans) strains, depending on the source of the keratin that they use for nutritional purposes.
  
  
  OBJECTIVE
  The in vitro susceptibility of clinical isolates of dermatophyte fungi has been studied in the 3 ecological groups with several antifungal agents for the topical management of dermatophytoses in order to determine their relationship with the ecological group.
  
  
  METHODS
  A standardised dilution micromethod in a liquid medium was used for the determination of the in vitro antifungal activity of 9 topical antifungal drugs: amorolfine (AMR), bifonazole (BFZ), clotrimazole, econazole, ketoconazole, miconazole, oxiconazole, terbinafine (TRB) and tioconazole. The in vitro activity was obtained against 124 clinical isolates of dermatophyte moulds from the anthropophilic, zoophilic and geophilic ecological groups.
  
  
  RESULTS
  The in vitro antifungal activity was different depending on the ecological group, although a species-dependent profile was also observed.
  
  
  CONCLUSIONS
  Azole derivatives showed a similar antifungal profile, being more active against anthropophilic dermatophytes > zoophilic > geophilic. Activity of TRB and AMR was different from that of azole derivatives (zoophilic > anthropophilic > geophilic). A higher in vitro antifungal activity against the 3 ecological groups was observed with TRB and AMR, whilst BFZ was the less active drug.
authors: Departamento de Microbiología, ACIAM, Barcelona, España. acarrillo@aciam.es
authors: Alfonso Javier
authors: AJ
authors: Carrillo-Muñoz
authors: Cristina
authors: C
authors: Tur-Tur
authors: Delia
authors: D
authors: Cárdenes
authors: Florencia
authors: F
authors: Rojas
authors: Gustavo
authors: G
authors: Giusiano
mesh_terms: D000820:Animal Diseases / Q000382:microbiology; D000818:Animals; D000935:Antifungal Agents / Q000145:classification / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D025141:Drug Resistance, Fungal; D026141:Drug Resistance, Multiple, Fungal; D004821:Epidermophyton / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D058507:Host Specificity; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D009181:Mycoses / Q000382:microbiology / Q000662:veterinary; D012988:Soil Microbiology; D013045:Species Specificity; D014249:Trichophyton / Q000145:classification / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000935:Antifungal Agents