title: Aligned electrospun nanofibers for ultra-thin layer chromatography.
abstract: The fabrication and implementation of aligned electrospun polyacrylonitrile (PAN) nanofibers as a stationary phase for ultra-thin layer chromatography (UTLC) is described. The aligned electrospun UTLC plates (AE-UTLC) were characterized to give an optimized electrospun mat consisting of high nanofiber alignment and a mat thickness of ~25 μm. The AE-UTLC devices were used to separate a mixture of β-blockers and steroidal compounds to illustrate the properties of AE-UTLC. The AE-UTLC plates provided shorter analysis time (~2-2.5 times faster) with improved reproducibility (as high as 2 times) as well as an improvement in efficiency (up to100 times greater) relative to non-aligned electrospun-UTLC (E-UTLC) devices.
authors: Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18(th) Ave., Columbus, OH 43210, USA.
authors: Michael C
authors: MC
authors: Beilke
authors: Joseph W
authors: JW
authors: Zewe
authors: Jonathan E
authors: JE
authors: Clark
authors: Susan V
authors: SV
authors: Olesik
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000319:Adrenergic beta-Antagonists / Q000302:isolation & purification*; D002855:Chromatography, Thin Layer / Q000295:instrumentation*; D004867:Equipment Design; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation; D015203:Reproducibility of Results; D013256:Steroids / Q000302:isolation & purification*
chemical_list: D000180:Acrylic Resins; D000319:Adrenergic beta-Antagonists; D013256:Steroids; C010504:polyacrylonitrile