title: The NuRD architecture.
abstract: The nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin organization, gene transcription, genomic stability and developmental signaling. NuRD has a unique dual enzymatic activity, containing an ATPase and a histone deacetylase among its six core subunits. Recent studies indicate that NuRD composition and the interplay between subunits may dictate the diverse functions of the complex. In this review, we examine the structures and biological roles of the NuRD subunits and discuss new avenues of research to advance our understanding of the NuRD-mediated signaling network.
authors: Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
authors: Hillary F
authors: HF
authors: Allen
authors: Paul A
authors: PA
authors: Wade
authors: Tatiana G
authors: TG
authors: Kutateladze
mesh_terms: D000818:Animals; D006801:Humans; D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex