title: Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus?
abstract: A recent publication indicated that overexpression of Axl, a cellular receptor that negatively regulates Toll-like receptor signaling, enhanced the entry of viruses pseudotyped with the glycoprotein of lymphocytic choriomeningitis virus (LCMV) in vitro. In testing the biological relevance of these observations, we found differences in neither viral kinetics between LCMV infections of Axl(-/-) and wild-type mice nor T-cell responses prior to spontaneous viral clearance. Thus, Axl is not required for productive LCMV infection of mice.
authors: Viral-Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
authors: Brian M
authors: BM
authors: Sullivan
authors: Megan J
authors: MJ
authors: Welch
authors: Greg
authors: G
authors: Lemke
authors: Michael B A
authors: MB
authors: Oldstone
mesh_terms: D000818:Animals; D001117:Arenaviridae Infections / Q000503:physiopathology*; D018050:Arenavirus / Q000378:metabolism* / Q000502:physiology; D005453:Fluorescence; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D053586:Virus Internalization; D000094963:Axl Receptor Tyrosine Kinase
chemical_list: D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases; D000094963:Axl Receptor Tyrosine Kinase