title: Association analysis of polymorphisms in ROCK2 with cardiovascular disease in a Chinese population.
abstract: BACKGROUND
  Rho-kinase (ROCK) has been shown to play an important role in cardiovascular disease such as coronary artery disease (CAD) and hypertension. Recently, common variants of ROCK2 have been reported to influence blood pressure, but the relationship between common ROCK2 variants and cardiovascular disease has not been extensively studied in the Chinese population.
  
  
  METHODS
  To derive a more precise estimation of their relationship, we screened for the common variants by direct sequencing of all exons of ROCK2, and then we performed genetic association analyses in a CAD case-control study, including a total of 1344 cases and 1267 ethnically and geographically matched controls.
  
  
  RESULTS
  Unconditional logistic regression showed that no significant association between common variants in the coding region of ROCK2 and CAD was observed in our study (for rs978906, OR = 0.92, 95% CI 0.72-1.20 and P = 0.63; for rs2230774, OR = 0.90, 95% CI 0.70-1.16 and P = 0.47; for rs56304104, OR = 0.97, 95% CI 0.70-1.31 and P = 0.83; respectively).
  
  
  CONCLUSIONS
  The relationship between the ROCK2 polymorphisms and cardiovascular disease risk cannot be entirely discounted and warrants further evaluation in a large population.
authors: Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors: Lei
authors: L
authors: Liu
authors: Yanyan
authors: Y
authors: Cao
authors: Guanglin
authors: G
authors: Cui
authors: Zongzhe
authors: Z
authors: Li
authors: Jing
authors: J
authors: Sun
authors: Lina
authors: L
authors: Zhang
authors: Chen
authors: C
authors: Chen
authors: Yan
authors: Y
authors: Wang
authors: Peihua
authors: P
authors: Wang
authors: Hu
authors: H
authors: Ding
authors: Dao Wen
authors: DW
authors: Wang
mesh_terms: D000368:Aged; D000792:Angiography; D001794:Blood Pressure / Q000235:genetics; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D054460:rho-Associated Kinases / Q000235:genetics*
chemical_list: C515852:ROCK2 protein, human; D054460:rho-Associated Kinases