title: Evidence-based toxicology for the 21st century: opportunities and challenges.
abstract: The Evidence-based Toxicology Collaboration (EBTC) was established recently to translate evidence-based approaches from medicine and health care to toxicology in an organized and sustained effort. The EBTC held a workshop on "Evidence-based Toxicology for the 21st Century: Opportunities and Challenges" in Research Triangle Park, North Carolina, USA on January 24-25, 2012. The presentations largely reflected two EBTC priorities: to apply evidence-based methods to assessing the performance of emerging pathway-based testing methods consistent with the 2007 National Research Council report on "Toxicity Testing in the 21st Century" as well as to adopt a governance structure and work processes to move that effort forward. The workshop served to clarify evidence-based approaches and to provide food for thought on substantive and administrative activities for the EBTC. Priority activities include conducting pilot studies to demonstrate the value of evidence-based approaches to toxicology, as well as conducting educational outreach on these approaches.
authors: Johns Hopkins University, Baltimore, MD, USA. mstephen@jhsph.edu
authors: Martin L
authors: ML
authors: Stephens
authors: Melvin
authors: M
authors: Andersen
authors: Richard A
authors: RA
authors: Becker
authors: Kellyn
authors: K
authors: Betts
authors: Kim
authors: K
authors: Boekelheide
authors: Ed
authors: E
authors: Carney
authors: Robert
authors: R
authors: Chapin
authors: Dennis
authors: D
authors: Devlin
authors: Suzanne
authors: S
authors: Fitzpatrick
authors: John R
authors: JR
authors: Fowle
authors: Patricia
authors: P
authors: Harlow
authors: Thomas
authors: T
authors: Hartung
authors: Sebastian
authors: S
authors: Hoffmann
authors: Michael
authors: M
authors: Holsapple
authors: Abigail
authors: A
authors: Jacobs
authors: Richard
authors: R
authors: Judson
authors: Olga
authors: O
authors: Naidenko
authors: Tim
authors: T
authors: Pastoor
authors: Grace
authors: G
authors: Patlewicz
authors: Andrew
authors: A
authors: Rowan
authors: Roberta
authors: R
authors: Scherer
authors: Rashid
authors: R
authors: Shaikh
authors: Ted
authors: T
authors: Simon
authors: Douglas
authors: D
authors: Wolf
authors: Joanne
authors: J
authors: Zurlo
mesh_terms: D000818:Animals; D015415:Biomarkers; D057166:High-Throughput Screening Assays; D006801:Humans; D015203:Reproducibility of Results; D014116:Toxicology / Q000331:legislation & jurisprudence / Q000379:methods* / Q000592:standards*; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D015415:Biomarkers