title: The role of VEGF and its soluble receptor VEGFR-1 in preterm newborns of preeclamptic mothers with RDS.
abstract: OBJECTIVE
  We measured vascular endothelial growth factor (VEGF) and soluble VEGF receptor 1(sVEGFR-1) concentrations in cord blood and tracheal aspirate fluid (TAF) in order to investigate the role of them in lung maturation and the severity of respiratory distress syndrome (RDS) in preterm newborns, born to preeclamptic mothers.
  
  
  METHODS
  Newborns were divided into two groups as preterms born to preeclamptic mothers and preterms born to healthy mothers. They were also divided into two groups as severe RDS (sRDS) and mild RDS (mRDS) according to the need of surfactant and extent or type of ventilatory support. The concentrations of VEGF and sVEGFR-1 in cord blood and TAF (only in preterms with sRDS) were assayed by standardized enzyme-linked immunosorbent assay.
  
  
  RESULTS
  When the patients were evaluated as sRDS and mRDS, cord blood VEGF and VEGF/sVEGFR-1 concentrations of preterms with sRDS were significantly lower than the concentrations of preterms with mRDS. Conversely, cord blood sVEGFR-1 concentrations of preterms with sRDS were significantly higher than the concentrations of preterms with mRDS. VEGF and sVEGFR-1 concentrations in TAF could be compared only between sRDS preterms, born to preeclampsia (+) and (-) mothers. No statistical significance was detected between the two groups when sVEGFR-1, VEGF and VEGF/sVEGFR-1 concentrations in TAF were compared.
  
  
  CONCLUSIONS
  Preeclampsia seems not to have an important effect on VEGF and sVEGFR-1 concentrations of preterm newborns both in cord blood and in TAF. Low VEGF and high sVEGFR-1 concentrations seem to be associated with the severity of RDS irrespective of preeclampsia, suggesting that VEGF may be one of the main components of lung maturation.
authors: Department of Pediatrics, Akdeniz University Medical School, Antalya, Turkey.
authors: Salih
authors: S
authors: Kalay
authors: Burak
authors: B
authors: Cakcak
authors: Osman
authors: O
authors: Oztekin
authors: Gonul
authors: G
authors: Tezel
authors: Ozgur
authors: O
authors: Tosun
authors: Mustafa
authors: M
authors: Akcakus
authors: Nihal
authors: N
authors: Oygur
mesh_terms: D001826:Body Fluids / Q000737:chemistry / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000737:chemistry / Q000378:metabolism; D005325:Fetal Organ Maturity / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood* / Q000378:metabolism*; D008168:Lung / Q000196:embryology / Q000502:physiology; D008297:Male; D009994:Osmolar Concentration; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis / Q000378:metabolism; D011247:Pregnancy; D011379:Prognosis; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism*; D012720:Severity of Illness Index; D012995:Solubility; D014132:Trachea / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000032:analysis / Q000097:blood / Q000378:metabolism / Q000502:physiology*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1