title: Taurine enhances antinociception produced by a COX-2 inhibitor in an inflammatory pain model.
abstract: The temporal activation of the sensory systems, especially in pain, determines intermediate states that define the future of the response to sensory stimulation. In this work, we interfere pharmacologically with those states that produce peripheral and central sensitisation after an acute inflammatory process, inhibiting at the periphery the COX-2 with celecoxib and using taurine (glycine A receptor agonist) for central pain relief. We tested the paw withdrawal reflex latencies to thermo- and mechanonociception after the induction of an acute inflammatory process with carrageenan. Celecoxib at low doses [0.13 and 1.3 mg/kg, intraperitoneal (i.p.)] in combination with taurine (300 mg/kg, i.p.) produces a decrease of the nociceptive response in thermo- and mechanonociception, as compared with the effect of both drugs alone. We propose that the enhancement of the analgesic effect of celecoxib in combination with taurine could be due the simultaneous action of these drugs at both, peripheral and central levels.
authors: Laboratorio de Neurofisiología Integrativa, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, México, D.F., C.P. 14370, Mexico.
authors: Beatriz
authors: B
authors: de Rienzo-Madero
authors: Ulises
authors: U
authors: Coffeen
authors: Karina
authors: K
authors: Simón-Arceo
authors: Francisco
authors: F
authors: Mercado
authors: Orlando
authors: O
authors: Jaimes
authors: Lucía
authors: L
authors: Magis-Weinberg
authors: Bernardo
authors: B
authors: Contreras
authors: Francisco
authors: F
authors: Pellicer
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D002351:Carrageenan; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement; D011720:Pyrazoles / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013449:Sulfonamides / Q000627:therapeutic use*; D013654:Taurine / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D013654:Taurine; D002351:Carrageenan; D000068579:Celecoxib