title: Influence of different types of commercially available microcrystalline cellulose on degradation of perindopril erbumine and enalapril maleate in binary mixtures.
abstract: Influence of some commercially available types of microcrystalline cellulose (MCC) on the stability of certain active pharmaceutical ingredients (APIs), when in contact, has been investigated. Two structurally similar APIs, perindopril erbumine (PER) and enalapril maleate (EM), both well-known angiotensin-converting enzyme inhibitors were used. The main properties of an MCC that could determine the stability for each API were measured and correlated to the stability of these two APIs in binary mixtures. The stability of these APIs differed when in contact with different types of MCC. The dominant properties of MCC from one manufacturer were surface features that influenced the stability of PER and acidity that influenced the stability of EM. In the case of MCC from other manufacturers, unbound water was stability determining for both substances.
authors: Krka d.d. Novo mesto, Stability Testing Department, 8501 Novo mesto Slovenia.
authors: Tanja
authors: T
authors: Vehovec
authors: Andrej
authors: A
authors: Gartner
authors: Odon
authors: O
authors: Planinšek
authors: Aleš
authors: A
authors: Obreza
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004339:Drug Compounding; D004355:Drug Stability; D004656:Enalapril / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry*; D020913:Perindopril / Q000737:chemistry*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004338:Drug Combinations; D005079:Excipients; D004656:Enalapril; D002482:Cellulose; C109691:microcrystalline cellulose; D020913:Perindopril