title: Effect of Bioritm-E phytococktail and experimental medicinal drug from spurdog liver Skvaakan on microcirculation, platelet aggregation, and thromboresistance of vascular wall in rats.
abstract: The study compared the effects of phytococktail Bioritm-E (a multicomponent phytoadaptogen) and experimental preparation Skvaakan from the liver of Black Sea spurdog on systemic homeostasis, microcirculation, and blood lipid profile in 15 days of their daily administration. Skvaakan enhanced the platelet activity producing no effect on vascular thromboresistance. Bioritm-E phytococktail inhibited platelet activity and enhanced vascular thromboresistance. Both agents modified blood lipid profile by decreasing concentration of triglycerides and HDL; in addition, they strengthened the vascular wall and increased vascular resistance. These findings attest to similarity of some biomedical features of phytoadaptogen Bioritm-E and hydrobiont Skvaakan, although they produced different biological effects on platelet activity and vascular thromboresistance.
authors: Department of Biologic Active Substances, Institute of Biomedical Investigations of Vladikavkaz Scientific Center of RAS and the Government of Republic North Ossetia-Alania, Vladikavkaz, Russia. faaroo@mail.ru
authors: F S
authors: FS
authors: Datieva
authors: L G
authors: LG
authors: Khetagurova
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000737:chemistry*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts