title: Clinicopathological study of gall bladder carcinoma with special reference to gallstones: our 8-year experience from eastern India.
abstract: Gallbladder carcinoma (GBC) is the commonest cancer of the biliary tree and the most frequent cause of death from biliary malignancies. The incidence of GBC shows prominent geographic, age, race, and gender-related differences and is 4-7 times higher in patients with gallstones. This prompted us to study the clinicopathological aspects of the disease and the incidence of gallstones in gallbladder carcinoma patients, in this part of India. In this, combined retrospective (Jan 2004-March 2010) and prospective study (April 2010-Dec 2011) of eight years, 198 patients of gallbladder carcinoma (50 males and 148 females), (range 28-82 years; mean 55 years) were studied. Most of the patients were poor and presented with abdominal pain and mass, with abnormal lab parameters. Gallstones were present in 86% of patients. Surgical exploration was performed in 130, with gallbladder resection in 60 (including 7 incidental GBC). Adenocarcinoma (87.7%) was the commonest histological type. The study indicates that GBC is common in our scenario. It is a disease of elderly females, has a strong association with gallstones and every cholecystectomy specimen should be examined histopathologically.
authors: Department of Surgical Gastroenterology, The Calcutta Medical Research Institute, Kolkata, India. drnisarhamdani@gmail.com
authors: Nissar Hussain
authors: NH
authors: Hamdani
authors: Sumyra Khurshid
authors: SK
authors: Qadri
authors: Ramesh
authors: R
authors: Aggarwalla
authors: Vishnu Kumar
authors: VK
authors: Bhartia
authors: Sumit
authors: S
authors: Chaudhuri
authors: Sanjay
authors: S
authors: Debakshi
authors: Sarfaraz Jalil
authors: SJ
authors: Baig
authors: N K
authors: NK
authors: Pal
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002763:Cholecystectomy; D005260:Female; D005500:Follow-Up Studies; D005706:Gallbladder Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D042882:Gallstones / Q000453:epidemiology / Q000209:etiology* / Q000601:surgery; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D013997:Time Factors