title: Evaluation of anti-arthritic potential of the methanolic extract of the aerial parts of Costus speciosus.
abstract: OBJECTIVE
  Costus speciosus Koen. (Keu, Crape ginger), an ornamental plant, widely distributed in India is traditionally used as astringent, aphrodisiac, purgative, anthelmintic, depurative, febrifuge and expectorant. The plant is also used in rheumatism, dropsy, urinary diseases and jaundice. The purpose of this study is to evaluate the anti-arthritic activity of the methanolic extract of the aerial parts of Costus speciosus (CS) in experimental animal models.
  
  
  METHODS
  The powdered drug was subjected to successive solvent extraction, with solvents in increasing order of polarity to obtain the methanolic extract of the aerial parts of the plant. CS was evaluated for anti-arthritic action by Freund's adjuvant induced arthritis test in adult Albino rats (150-200 gm). Rats were injected 0.1 ml of complete Freund's adjuvant into the planter region of the left hind paw. Statistical analysis was performed using One way analysis of variance (ANOVA) followed by Bonferonni test. P<0.05 was considered statistically significant.
  
  
  RESULTS
  The methanolic extract of CS in doses of 400 and 800 mg/kg showed 75.50% and 68.33% protection against increase in paw edema, respectively. CS showed dose-dependent action in all the experimental models.
  
  
  CONCLUSIONS
  The present study indicates that CS has significant anti-arthritic properties.
authors: Department of Pharmacognosy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
authors: Shruti
authors: S
authors: Srivastava
authors: Pradeep
authors: P
authors: Singh
authors: Keshri K
authors: KK
authors: Jha
authors: Garima
authors: G
authors: Mishra
authors: Sourabh
authors: S
authors: Srivastava
authors: Ratan L
authors: RL
authors: Khosa
keywords: Arthritis; Costus speciosus; Freund's complete adjuvant; diclofenac sodium; paw volume