title: [POEMS syndrome treated with lenalidomide plus high-dose dexamethasone as a pre-transplant induction therapy].
abstract: A 60-year-old male with POEMS syndrome received lenalidomide and high-dose dexamethasone combination therapy as an initial treatment, with no severe adverse events occurring during the treatment. Two cycles of the therapy led to significantly decreased serum VEGF level, and IgA-λ type M-protein was not detected by immunofixation electrophoresis. We next performed autologous stem cell transplantation, without severe complications such as engraftment syndrome. He improved enough to walk independently and now is being followed up without treatment. This case suggests that lenalidomide-dexamethasone therapy is highly effective and can be a good option for pre-transplant treatment for POEMS syndrome.
authors: Department of Hematology, Shizuoka Red Cross Hospital, Japan.
authors: Shiro
authors: S
authors: Matsuura
authors: Eriko
authors: E
authors: Ogusa
authors: Jun
authors: J
authors: Taguchi
authors: Noboru
authors: N
authors: Imai
authors: Hiroyuki
authors: H
authors: Fujita
authors: Naoto
authors: N
authors: Tomita
authors: Yoshiaki
authors: Y
authors: Ishigatsubo
authors: Shin
authors: S
authors: Fujisawa
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003907:Dexamethasone / Q000008:administration & dosage; D006801:Humans; D000077269:Lenalidomide; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects; D016878:POEMS Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods; D013792:Thalidomide / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D013792:Thalidomide; D003907:Dexamethasone; D000077269:Lenalidomide