title: Bilateral nevus comedonicus of the eyelids.
abstract: Nevus comedonicus is a rare developmental abnormality of the infundibulum of the hair follicle. It is usually unilateral and commonly presents at birth or during childhood. A rare case of late-onset, bilateral nevus comedonicus of the eyelids is reported. A 79-year-old man presented with asymptomatic but disfiguring eyelid lesions noted several months earlier. On physical examination, multiple papules resembling comedones were present bilaterally in the eyelids, canthi, temple regions, and bridge of the nose. Microscopically, there were deep invaginations of the follicular canals forming focal tunnels or pseudosinus tracts with poral openings to the surface. These variably cystic structures were lined by keratinizing and nonkeratinizing squamous epithelium, contained concentric lamellae of keratin in their lumens, and some were acutely or chronically inflamed. The diagnosis of a nevus comedonicus was made. The clinical and histopathologic characteristics, pathogenesis, differential diagnosis, and management of nevus comedonicus are briefly discussed.
authors: David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts 02114, USA.
authors: Pia R
authors: PR
authors: Mendoza
authors: Frederick A
authors: FA
authors: Jakobiec
authors: Daniel J
authors: DJ
authors: Townsend
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000473:pathology*; D005143:Eyelids / Q000002:abnormalities*; D006801:Humans; D008297:Male; D009506:Nevus / Q000473:pathology*; D035583:Rare Diseases / Q000473:pathology