title: Gastro-pleuro-pericardial fistula following combined radiation and chemotherapy for lung metastases from renal cell carcinoma: report of a case.
abstract: Gastropleural and gastropericardial fistulas are abnormal communications between the stomach and the pleural cavity or pericardium. They are rare and life-threatening complications, which require prompt surgical intervention. We report the case of a gastro-pleuro-pericardial fistula that developed in a patient treated with radiotherapy and then Sunitinib (Sutent(®)), a novel tyrosine-kinase inhibitor, for lung metastases from renal cell carcinoma. To our knowledge, this is the first case of a gastro-pleuro-pericardial fistula developing as a consequence of combined radiation and chemotherapy.
authors: Section of General Surgery and Surgical Oncology, Department of Human Pathology and Oncology, University of Siena, viale Bracci, Policlinico "Le Scotte", 53100, Siena, Italy.
authors: Alessandro
authors: A
authors: Neri
authors: Youdel
authors: Y
authors: Lambert
authors: Daniele
authors: D
authors: Marrelli
authors: Giulio
authors: G
authors: Di Mare
authors: Doralba
authors: D
authors: Mastrogiacomo
authors: Giovanni
authors: G
authors: Corso
authors: Luca
authors: L
authors: Volterrani
authors: Franco
authors: F
authors: Roviello
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000494:pharmacology; D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000628:therapy*; D059248:Chemoradiotherapy / Q000009:adverse effects*; D004791:Enzyme Inhibitors / Q000009:adverse effects* / Q000494:pharmacology; D005402:Fistula / Q000209:etiology* / Q000601:surgery; D005747:Gastric Fistula / Q000209:etiology* / Q000601:surgery; D006331:Heart Diseases / Q000209:etiology* / Q000601:surgery; D006801:Humans; D007211:Indoles / Q000009:adverse effects* / Q000494:pharmacology; D007680:Kidney Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010496:Pericardium; D010995:Pleural Diseases / Q000209:etiology* / Q000601:surgery; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011758:Pyrroles / Q000009:adverse effects* / Q000494:pharmacology; D000077210:Sunitinib; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D007211:Indoles; D011758:Pyrroles; D011505:Protein-Tyrosine Kinases; D000077210:Sunitinib