title: Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure.
abstract: Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 μm (lateral) × 7 μm (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.
authors: Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors: Michalina J
authors: MJ
authors: Gora
authors: Jenny S
authors: JS
authors: Sauk
authors: Robert W
authors: RW
authors: Carruth
authors: Kevin A
authors: KA
authors: Gallagher
authors: Melissa J
authors: MJ
authors: Suter
authors: Norman S
authors: NS
authors: Nishioka
authors: Lauren E
authors: LE
authors: Kava
authors: Mireille
authors: M
authors: Rosenberg
authors: Brett E
authors: BE
authors: Bouma
authors: Guillermo J
authors: GJ
authors: Tearney
mesh_terms: D001471:Barrett Esophagus / Q000000981:diagnostic imaging; D053704:Capsule Endoscopy / Q000379:methods*; D005767:Gastrointestinal Diseases / Q000175:diagnosis; D041981:Gastrointestinal Tract / Q000648:ultrastructure*; D006801:Humans; D014463:Ultrasonography