title: The role of NF-кB in SAA-induced peroxisome proliferator-activated receptor γ activation.
abstract: Serum amyloid A (SAA) is an acute phase protein whose expression increases markedly during bacterial infection, tissue damage, and inflammation. The potential beneficial roles of SAA include its involvement in the reverse cholesterol transport and possibly extracellular lipid deposition at sites of inflammation and tissue repair. It is an attractive therapeutic target for the treatment of atherosclerosis. Peroxisome proliferator-activated receptor γ (PPARγ) plays a major regulatory role in adipogenesis, and the expression of genes involved in lipid metabolism. Activation of PPARγ leads to multiple changes in gene expression, some of which are believed to be atherogenic while others are antiatherogenic. In this study, we demonstrated that SAA upregulated COX-2 expression and induced PPARγ activity through NF-кB pathway. The effect of SAA on NF-кB activity is mediated by FPRL-1 and TLR4.
authors: Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore. g0700131@nus.edu.sg
authors: Hongzhe
authors: H
authors: Li
authors: Shu Qin
authors: SQ
authors: Ooi
authors: Chew-Kiat
authors: CK
authors: Heng
mesh_terms: D051546:Cyclooxygenase 2; D005419:Flavonoids / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D008075:Lipoproteins, HDL / Q000502:physiology; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000502:physiology*; D047495:PPAR gamma / Q000378:metabolism*; D044042:Receptors, Formyl Peptide / Q000502:physiology; D044067:Receptors, Lipoxin / Q000502:physiology; D000685:Serum Amyloid A Protein / Q000502:physiology*; D051197:Toll-Like Receptor 4 / Q000502:physiology
chemical_list: C105101:FPR2 protein, human; D005419:Flavonoids; D008075:Lipoproteins, HDL; D016328:NF-kappa B; D047495:PPAR gamma; D044042:Receptors, Formyl Peptide; D044067:Receptors, Lipoxin; D000685:Serum Amyloid A Protein; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; C093973:2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one