[(3)H]UR-PLN196: a selective nonpeptide radioligand and insurmountable antagonist for the neuropeptide Y Y(2) receptor.
Radioing in on NPY: Attachment of a [2,3-(3)H]propionyl group through an appropriate linker to the guanidine group of an (S)-argininamide-type neuropeptide Y (NPY) Y(2) receptor antagonist resulted in a subtype-selective radioligand.
Institut für Pharmazie, Pharmazeutische/Medizinische Chemie, Universität Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.
Nikola
N
Pluym
Paul
P
Baumeister
Max
M
Keller
Günther
G
Bernhardt
Armin
A
Buschauer
D001120:Arginine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D020013:Calcium Signaling; D003984:Dibenzazepines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D008024:Ligands; D009478:Neuropeptide Y / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011485:Protein Binding; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014316:Tritium / Q000737:chemistry
C583430:(3H)UR-PLN196; D003984:Dibenzazepines; D008024:Ligands; D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y; C095889:neuropeptide Y2 receptor; D014316:Tritium; D001120:Arginine