An investigation of simultaneous variations in cerebral blood flow velocity and arterial blood pressure during sleep apnea.
Obstructive Sleep Apnea (OSA) is a major sleep disorder with a prevalence of about 15 % among US adult population and can lead to cardiovascular diseases and stroke. In this study, we have investigated the OSA-induced concurrent rise in cerebral blood flow velocity and blood pressure in 5 positively diagnosed sleep apnea subjects. The subject population had a mean AHI of 57.94±25.73 and BMI of 33.66±7.27 kg/m(2). The results of this preliminary study yielded a relatively high correlation between rise in blood pressure and rise in cerebral blood flow velocity during apnea episodes (r=0.61±0.16) compared to normal breathing (r=0.28±0.26). These findings suggest that cerebral autoregulation may be less effective during apnea episodes.
Bioengineering Department, University of Texas at Arlington, Arlington, TX 76010, USA. raichelmary.alex@ mavs.uta.edu
Raichel
R
Alex
Gauri
G
Bhave
Mohammad A
MA
Al-Abed
Aditya
A
Bashaboyina
Swathi
S
Iyer
Donald E
DE
Watenpaugh
Rong
R
Zhang
Khosrow
K
Behbehani
D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*