[The relationship between serum parathormone levels and the severity of coronary artery disease].
OBJECTIVE
It has been reported that increased parathormone (PTH) levels have unfavorable effects on the cardiovascular system. PTH produces unfavorable effects via either PTH receptors or the renin angiotensin aldosterone system. Data shows that there is a relationship between PTH and coronary artery disease (CAD), although this relationship is still being debated. In this study, we evaluate the relationship between serum PTH levels and CAD.


METHODS
The study included 260 patients (125 males, 135 females, mean age 56.01±11.9 years) who underwent coronary angiography with a prediagnosis of CAD. Venous blood samples were taken 6 hours before the coronary angiography for the measurement of serum PTH levels. The extent of CAD was evaluated by calculation of Gensini scores.


RESULTS
The Gensini score was 0 in 99 of the patients. Mild atherosclerosis and severe atherosclerosis were determined in 67 and 94 patients, respectively. According to the Gensini score, serum PTH levels were 5.17±2.07 pmol/l, 4.88±2.40 pmol/l and 4.98±3.04 pmol/l, respectively. PTH levels were similar in patients with mild atherosclerosis and with normal coronary arteries (Gensini score 0) (p=0.55). There was no difference in PTH levels between patients with mild and severe atherosclerosis (p=0.77). In addition, no significant difference in PTH levels were detected between those with normal coronary arteries and those with severe atherosclerosis (p=0.78).


CONCLUSIONS
Serum PTH level does not determine the extensity of CAD.
Department of Cardiology, Gelibolu State Hospital, Çanakkale, Trukey. dr.deryaerbas@hotmail.com
Derya
D
Oztürk
Ozlem
O
Ozcan Çelebi
Feridun Vasfi
FV
Ulusoy
Sinan
S
Aydoğdu
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012720:Severity of Illness Index; D014807:Vitamin D / Q000097:blood
D010281:Parathyroid Hormone; D014807:Vitamin D; D002097:C-Reactive Protein