New PAH derivatives functionalized by cyclic nitrone framework: synthetic design, anti-proliferative activity and interaction with DNA.
Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. Incorporation of cyclic nitrone framework into the structure of PAHs was studied with respect to their anti-proliferative activities and interaction with double stranded DNA. Theoretical docking studies and UV titration methods were used for preliminary evaluation of binding of new PAH derivatives to DNA structure.
Department of Chemistry, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.
Marian
M
Buchlovič
Zdeněk
Z
Kříž
Ctirad
C
Hofr
Milan
M
Potáček
D001665:Binding Sites; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D015195:Drug Design; D045325:HCT116 Cells; D006801:Humans; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D020014:K562 Cells; D061986:MCF-7 Cells; D062105:Molecular Docking Simulation; D009589:Nitrogen Oxides / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D013329:Structure-Activity Relationship
D007364:Intercalating Agents; D009589:Nitrogen Oxides; D011084:Polycyclic Aromatic Hydrocarbons; C015388:nitrones; D004247:DNA