Antibody-dependent cell-mediated virus inhibition antibody activity does not correlate with risk of HIV-1 superinfection.
Previous studies of HIV-infected women with high-risk behavior have indicated that neither neutralizing antibody nor cellular immunity elicited by an initial HIV-1 infection is associated with protection against superinfection with a different HIV-1 strain. Here, we measured antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity in the plasma of 12 superinfected cases and 36 singly infected matched controls against 2 heterologous viruses. We found no association between plasma ADCVI activity and superinfection status. ADCVI antibody activity against heterologous virus elicited by the original infection may not contribute to preventing a superinfecting HIV-1.
Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92967, USA. dnfortha@uci.edu
Donald N
DN
Forthal
Gary
G
Landucci
Bhavna
B
Chohan
Barbra A
BA
Richardson
R Scott
RS
McClelland
Walter
W
Jaoko
Catherine
C
Blish
Julie
J
Overbaugh
D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D007630:Kenya; D015163:Superinfection / Q000276:immunology* / Q000517:prevention & control / Q000821:virology
D057134:Antibodies, Neutralizing; D015483:HIV Antibodies