Transient receptor potential canonical type 3 channels--their evolving role in hypertension and its related complications.
: Recent studies indicate that transient receptor potential canonical type 3 (TRPC3) channels contribute to the regulation of blood pressure and vascular and renal function. Several studies show that TRPC3 dysfunction is associated with hypertension, atherosclerosis, cardiac hypertrophy, and cerebrovascular events. In this review, we summarize the role of TRPC3 channels in the cardiovascular system, and we focus on their pathophysiological role in hypertension and related target organ damages. We provide new insight into the involvement of TRPC3 channels in the development of hypertension and its related complications.
Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China.
Peijian
P
Wang
Daoyan
D
Liu
Martin
M
Tepel
Zhiming
Z
Zhu
D001794:Blood Pressure / Q000502:physiology; D002319:Cardiovascular System; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D050052:TRPC Cation Channels / Q000502:physiology*
D050052:TRPC Cation Channels; C104603:TRPC3 cation channel