Epigenetic regulation of estrogen signaling in breast cancer.
Estrogen signaling is mediated by ERα and ERβ in hormone dependent, breast cancer (BC). Over the last decade the implication of epigenetic pathways in BC tumorigenesis has emerged: cancer-related epigenetic modifications are implicated in both gene expression regulation, and chromosomal instability. In this review, the epigenetic-mediated estrogen signaling, controlling both ER level and ER-targeted gene expression in BC, are discussed: (1) ER silencing is frequently observed in BC and is often associated with epigenetic regulations while chemical epigenetic modulators restore ER expression and increase response to treatment;(2) ER-targeted gene expression is tightly regulated by co-recruitment of ER and both coactivators/corepressors including HATs, HDACs, HMTs, Dnmts and Polycomb proteins.
Université de Franche-Comté, Laboratoire de Biochimie, EA3922, Expression Génique et Pathologies du Système Nerveux Central, SFRIBCT FED 4234, UFR Sciences et Techniques, Besançon, France. eric.hervouet@univ-fcomte.fr
Eric
E
Hervouet
Pierre-François
PF
Cartron
Michèle
M
Jouvenot
Régis
R
Delage-Mourroux
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D044127:Epigenesis, Genetic; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D011960:Receptors, Estrogen / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D004967:Estrogens; D011960:Receptors, Estrogen; D014157:Transcription Factors
DNA methylation; breast cancer; epigenetic; estrogen; histones