Application of scaffolds for bone regeneration strategies: current trends and future directions.
Scaffolds are extensively used in surgery to replace missing bone and to achieve bony union and fusion. An ideal scaffold should not only maintain, induce, and restore biological functions where cells, extracellular matrix, and growth factors are needed, but also have the right properties with respect to degradation, cell binding, cellular uptake, non-immunogenicity, mechanical strength, and flexibility. Here we examine both the basic science behind the development of scaffolds and comprehensively and systematically review the clinical applications.
Department of Orthopedics, Uppsala University, Uppsala, Sweden.
Gry Hulsart
GH
Billström
Ashley W
AW
Blom
Sune
S
Larsson
Andrew D
AD
Beswick
D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000494:pharmacology; D005109:Extracellular Matrix / Q000737:chemistry*; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000494:pharmacology; D018021:Lithium Chloride / Q000494:pharmacology; D008297:Male; D013324:Strontium / Q000494:pharmacology; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D054457:Tissue Scaffolds / Q000737:chemistry*
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D020100:Hydrogels; C020243:calcium phosphate; D018021:Lithium Chloride; D013324:Strontium