NQO1 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia.
OBJECTIVE
To investigate the relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism and colon cancer risk in farmers from western region of Inner Mongolia.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to analyze NQO1 C609T polymorphism from 160 healthy controls and 76 colon cancer patients.


RESULTS
Among the colon cancer patients, the incidence of NQO1 T allele (53.29%) was significantly higher than it in control group (33.75%, P<0.001). The individuals with NQO1 T allele had higher risk [2.239 (95% CI:  1.510-3.321) times] to develop colon cancer than individuals with NQO1 C allele. The incidence of NQO1  (T/T) (34.21%) in colon cancer patients was higher than that in control group (15.62%, P<0.001). Odds ratios (OR) analysis suggested that NQO1 (T/T) and NQO1 (T/C) genotype carriers had 3.813 (95% CI: 1.836-7.920) times and 2.080 (1.026-4.219) times risk compared with wild-type NQO1 (C/C) gene carriers in developing colon cancer. Individuals with NQO1 (T/T) genotype had 2.541 (95% CI: 0.990-6.552) times, 3.713 (95% CI: 1.542-8.935) times, and 3.471 (95% CI: 1.356-8.886) times risk than individuals with NQO1 (T/C) or NQO1 (C/C) genotype in well-differentiated, moderately-differentiated, and poorly-differentiated colon cancer patients, respectively.


CONCLUSIONS
NQO1 gene C609T could be one of risk factors of colon cancer in farmers from western region of Inner Mongolia.
Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical College, Hohhot 010050, China.
Xiu-Lan
XL
Su
Mei-Rong
MR
Yan
Ling
L
Yang
Colon cancer; Inner Mongolia; NAD(P)H:quinone oxidoreductase 1; gene polymorphism