An elementary analysis of physiologic shock and multi-organ failure: the autodigestion hypothesis.
Physiological shock and subsequent multi-organ failure is one of the most important medical problems from a mortality point of view. No agreement exists for mechanisms that lead to the relative rapid cell and organ failure during this process and no effective treatment. We postulate that the digestive enzymes synthesized in the pancreas and transported in the lumen of the small intestine as requirement of normal food digestion play a central role in multi-organ failure. These powerful enzymes are usually compartmentalized in the lumen of the intestine by the mucosal barrier, but may escape into the wall of the intestine if the permeability of the mucosal lining increases. Entry of the digestive enzymes into the wall of the intestine precipitates an autodigestion process as well as an escape of pancreatic enzymes and breakdown products generated by them into the system circulation. The consequence of autodigestion is multiorgan failure. We discuss the possibility to block the digestive enzymes in acute forms of shock as a potential therapeutic intervention.
Department of Bioengineering, The Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA 92093 – 0412, USA. gwss@eng.ucsd.edu
Geert W
GW
Schmid-Schonbein
Frank A
FA
DeLano
Alexander H
AH
Penn
Erik
E
Kistler
D006801:Humans; D007422:Intestines / Q000201:enzymology; D009102:Multiple Organ Failure / Q000201:enzymology*; D010179:Pancreas / Q000201:enzymology; D012769:Shock / Q000201:enzymology*