Implantable ultrasonic dual functional assembly for detection and treatment of anomalous growth.
High Intensity Focused Ultrasound (HIFU) is emerging as an accurate, noninvasive method for ablation of certain primary and metastatic tumors. Typically, ablation is performed with an external therapeutic transducer. However, external HIFU treatment suffers from limitations of low therapeutic efficiency for ablation of tumors, deep in internal organs such as liver, kidney and brain. Interstitial HIFU through an internal transducer, implanted locally near the organ of interest, could alleviate some of these limitations. Furthermore, it can be attractive for point-of-care (POC) treatment. In this paper, we propose the design of a dual-functional implantable assembly for image-guided HIFU treatment of anomalous growth. It is realized by effective integration of a central HIFU array with two ultrasonic imaging arrays for high-resolution online monitoring and efficient treatment. We explore the design space for the implant and identify the major design parameters including the power requirement. Using a widely used simulation platform, we show that the proposed implant, besides providing a potential POC solution, achieves a better therapeutic performance for certain tumor positions in internal organs, than the extracorporeal HIFU treatment.
Electrical Engineering and Computer Science Department, Case Western Reserve University, Cleveland, OH, USA. axb594@case.edu
Abhishek
A
Basak
Vaishnavi
V
Ranganathan
Seetharam
S
Narasimhan
Swarup
S
Bhunia
D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D019736:Prostheses and Implants; D014464:Ultrasonic Therapy / Q000295:instrumentation / Q000379:methods; D014463:Ultrasonography