Pregnancy in a woman with chronic neutrophilic leukemia.
BACKGROUND
Chronic neutrophilic leukemia is a rare myeloproliferative disorder in women of reproductive age.


METHODS
A pregnant woman with an established diagnosis of chronic neutrophilic leukemia presented at 26 weeks of gestation with splenomegaly, thrombocytopenia, leukocytosis, and anemia. Thrombocytopenia was refractory to medical treatment and, in part, was attributed to splenic sequestration. She delivered a healthy neonate at 35 weeks of gestation by repeat cesarean delivery under general anesthesia. Her preoperative platelet count was 30,000/mL and she was transfused platelets throughout the perioperative period. Her postpartum course was complicated by intraabdominal hemorrhage and severe preeclampsia. She recovered with intensive medical and surgical management.


CONCLUSIONS
Chronic neutrophilic leukemia poses difficult challenges during pregnancy and requires a multidisciplinary approach.
Department of Obstetrics and Gynecology, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, New York 10065, USA.
Jolyn
J
Taylor
Gail J
GJ
Roboz
Rebecca N
RN
Baergen
Mehmet R
MR
Genc
D034841:Abdominal Cavity / Q000601:surgery; D000328:Adult; D000740:Anemia / Q000209:etiology; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017604:Cesarean Section, Repeat; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015467:Leukemia, Neutrophilic, Chronic / Q000150:complications / Q000628:therapy*; D007964:Leukocytosis / Q000209:etiology; D017713:Platelet Transfusion; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000601:surgery; D011225:Pre-Eclampsia / Q000188:drug therapy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000628:therapy*; D013163:Splenomegaly / Q000209:etiology; D013921:Thrombocytopenia / Q000209:etiology
D000970:Antineoplastic Agents