Triggering cell adhesion, migration or shape change with a dynamic surface coating.
There's an APP for that: cell-repellent APP (azido-[polylysine-g-PEG]) is used to create substrates for spatially controlled dynamic cell adhesion. The simple addition of a functional peptide to the culture medium rapidly triggers cell adhesion. This highly accessible yet powerful technique allows diverse applications, demonstrated through tissue motility assays, patterned coculturing and triggered cell shape change.
École Normale Supérieure, Department of chemistry, UMR 8640 CNRS-ENS-UPMC, Paris, France. ENS@StijnvanDongen.nl
Stijn F M
SF
van Dongen
Paolo
P
Maiuri
Emmanuelle
E
Marie
Christophe
C
Tribet
Matthieu
M
Piel
D001386:Azides / Q000737:chemistry; D001643:Bridged Bicyclo Compounds / Q000737:chemistry; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects*; D048430:Cell Shape / Q000187:drug effects*; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011107:Polylysine / Q000737:chemistry; D013499:Surface Properties; D023822:Tissue Engineering
D001386:Azides; D001643:Bridged Bicyclo Compounds; D020099:Coated Materials, Biocompatible; D009842:Oligopeptides; C556617:bicyclo(6.1.0)nonyne; D011107:Polylysine; D011092:Polyethylene Glycols; C047981:arginyl-glycyl-aspartic acid