SnO(2)-ZnSn(OH)(6): a novel binary affinity probe for global phosphopeptide detection.
ZnSn(OH)(6) and binary-component SnO(2)-ZnSn(OH)(6) were introduced as affinity probes for phosphopeptide enrichment for the first time. Two strategies, either ZnSn(OH)(6) and SnO(2) serial enrichment or binary-component SnO(2)-ZnSn(OH)(6) enrichment in a single run, were proposed to enhance multi-phosphopeptide enrichment and to significantly improve global phosphopeptide detection.
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Li-Ping
LP
Li
Tao
T
Zheng
Lin-Nan
LN
Xu
Ze
Z
Li
Ling-Dong
LD
Sun
Zong-Xiu
ZX
Nie
Yu
Y
Bai
Hu-Wei
HW
Liu
D002364:Caseins / Q000378:metabolism; D010748:Phosphopeptides / Q000032:analysis*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D017971:Tin Compounds / Q000737:chemistry*; D014357:Trypsin / Q000378:metabolism; D015032:Zinc / Q000737:chemistry*
D002364:Caseins; D010748:Phosphopeptides; D017971:Tin Compounds; D014357:Trypsin; D015032:Zinc; C045358:stannic oxide