A systems biology starter kit for arenaviruses.
Systems biology approaches in virology aim to integrate viral and host biological networks, and thus model the infection process. The growing availability of high-throughput “-omics” techniques and datasets, as well as the ever-increasing sophistication of in silico modeling tools, has resulted in a corresponding rise in the complexity of the analyses that can be performed. The present study seeks to review and organize published evidence regarding virus-host interactions for the arenaviruses, from alterations in the host proteome during infection, to reported protein-protein interactions. In this way, we hope to provide an overview of the interplay between arenaviruses and the host cell, and lay the foundations for complementing current arenavirus research with a systems-level approach.
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA. droniou@usc.edu
Magali E
ME
Droniou-Bonzom
Paula M
PM
Cannon
D018050:Arenavirus / Q000235:genetics / Q000472:pathogenicity*; D019295:Computational Biology / Q000379:methods; D054884:Host-Pathogen Interactions; D006801:Humans; D060066:Protein Interaction Maps; D040901:Proteomics; D049490:Systems Biology / Q000379:methods*; D014773:Virology / Q000379:methods*