Metamorphosis in a frog that does not have a tadpole.
The evolutionary removal of the tadpole from the frog life history is a very successful strategy, particularly in the tropics. These direct developers form limbs and a frog-like head early in embryogenesis, and they have reduced or lost tadpole-specific structures, like gills, a long, coiled intestine, and tadpole teeth and jaws. Despite the apparently continuous development to the frog morphology, the direct developer, Eleutherodactylus coqui, undergoes a cryptic metamorphosis requiring thyroid hormone. As in Xenopus laevis, there is a stimulation by corticotrophin-releasing factor (CRF) and an upregulation of thyroid hormone receptor β (thrb). In addition to changes in skin and muscle, thyroid hormone stimulates yolk utilization for froglet growth from a novel tissue, the nutritional endoderm. The activities of CRF and corticosterone (CORT) in metamorphosis may provide the basis for the multiple evolutionary origins of direct development in anuran amphibians. Potential roles for maternally supplied thyroid hormone and its receptor and for deiodinases in regulating tissue sensitivity to thyroid hormone should be the subjects of future investigations.
Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania, USA. elinson@duq.edu
Richard P
RP
Elinson
D000818:Animals; D001001:Anura / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D007814:Larva / Q000254:growth & development; D008675:Metamorphosis, Biological; D011988:Receptors, Thyroid Hormone / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism
D011988:Receptors, Thyroid Hormone; D013963:Thyroid Hormones