Vitamin B12 loaded polycaprolactone nanofibers: a novel transdermal route for the water soluble energy supplement delivery.
Biocompatible PCL polymer nanofiber mediated sustained release of hydrophilic drug and applicability as transdermal delivery system is attempted. This new attempt to investigate water soluble vitamin delivery with hydrophobic polymer nanofiber sustained the release of the vitamin and the method is suited for the transdermal patch applications. The drug loaded fibers were characterized with SEM for morphology, porometer for pore size measurements, mechanical strength calculation and FT-IR for drug load characterization. The contact angle measurement showed surface wettability and controlled release of drug was quantified with UV absorption measurements. To further enhance the release of vitamin, the polymer fiber was plasma treated at different time intervals and made hydrophilic gradually. Since the increased surface area and drug encapsulation in nano-reservoirs can able to release drug in small quantities and in a sustained manner we attempted the release of the energy supplement with nanofibrous delivery mode.
Center for Nanofibers and Nanotechnology, NUSNNI, National University of Singapore, Singapore.
Kalaipriya
K
Madhaiyan
Radhakrishnan
R
Sridhar
Subramanian
S
Sundarrajan
Jayarama Reddy
JR
Venugopal
Seeram
S
Ramakrishna
D019587:Dietary Supplements; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry*; D012995:Solubility; D057968:Transdermal Patch; D014805:Vitamin B 12 / Q000737:chemistry*; D014803:Vitamin B Complex / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D011091:Polyesters; D014867:Water; D014803:Vitamin B Complex; C016240:polycaprolactone; D014805:Vitamin B 12