High serum YKL-40 level in patients with COPD is related to hypoxemia and disease severity.
Chronic obstructive pulmonary disease (COPD) is a major health problem with increasing morbidity and mortality throughout the world. YKL-40 is a chitin-binding glycoprotein consisting of 383 amino acids, with a molecular mass of 40 kDa, and its serum level is elevated in inflammatory diseases. YKL-40 is a newly recognized biomarker of inflammation and has not been thoroughly investigated in COPD. The aim of the study is to investigate the relationship between serum YKL-40 levels and severity of COPD. The study population consisted of 52 patients with COPD with the mean age of 60.2 ± 10.1 years. The serum YKL-40 level increased significantly with increasing age (p = 0.022, r = 0.346). In COPD patients, high serum YKL-40 level is correlated to low forced expiratory volume at 1 second (FEV₁, percent of predicted) (r = -0.277, p = 0.047). Moreover, high serum YKL-40 level is correlated to low arterial oxygen pressure (PaO₂, mmHg) (r = -0.387, p = 0.005). The mean serum YKL-40 level was found as 243.1 ± 129.2 ng/ml in COPD patients with desaturation during 6-minute walk test (6MWT) and this value was higher than the mean serum YKL-40 level (155.8 ± 59.1 ng/ml) of COPD patients without desaturation during 6MWT (p = 0.004). This study demonstrated that high serum YKL-40 levels were correlated to severity of COPD. We propose that circulating YKL-40 levels could be a biomarker for hypoxemia and decline in lung function.
Department of Chest Disease, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey.
Aziz
A
Gumus
Servet
S
Kayhan
Halit
H
Cinarka
Aynur
A
Kirbas
Necati
N
Bulmus
Asiye
A
Yavuz
Unal
U
Sahin
Sevket
S
Ozkaya
D054392:Adipokines / Q000097:blood*; D016022:Case-Control Studies; D000071451:Chitinase-3-Like Protein 1; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D010313:Partial Pressure; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D012720:Severity of Illness Index
D054392:Adipokines; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins; D010100:Oxygen