Liver, plasma and erythrocyte levels of thiamine and its phosphate esters in rats with acute ethanol intoxication: a comparison of thiamine and benfotiamine administration.
Thiamine and benfotiamine are vitamin B1 and pro-vitamin B1 substances, respectively. Vitamin B1 plays an essential role in energy metabolism, and its deficiency leads to neurologic and cardiovascular pathologies, as seen in alcoholics. This study presents new data about the effects of thiamine hydrochloride or benfotiamine treatment given to rats with acute alcohol intoxication, on the distribution of thiamine and its phosphate esters in liver, plasma and erythrocytes. The treatments were effective in increasing thiamine levels in plasma, erythrocytes and liver cells. The benfotiamine-treated group had its total plasma thiamine increased by 100%. In erythrocytes, thiamine levels were 4- and 25-fold higher in the groups treated with thiamine and benfotiamine, respectively, compared with the untreated groups. Liver thiamine was increased by 60% in the treated groups compared with the untreated groups. Thus, we verified the high bioavailability especially of benfotiamine within 6h of ethanol administration.
Department of Nutrition, Federal University of Triangulo Mineiro, R. Getúlio Guaritá, 159, Rooms 323/321, 38 025-440 Uberaba, MG, Brazil. gvportari@nutricao.uftm.edu.br
Guilherme Vannucchi
GV
Portari
Helio
H
Vannucchi
Alceu Afonso
AA
Jordao
D000435:Alcoholic Intoxication / Q000097:blood*; D000818:Animals; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013831:Thiamine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D014815:Vitamins / Q000097:blood / Q000493:pharmacokinetics*
D014815:Vitamins; D013831:Thiamine; C013835:benphothiamine