An unusual cause of severe persistent neutropenia in a child with nephrotic syndrome.
A 5-year-old boy presented with neutropenia 9 weeks following the administration of rituximab for management of his steroid-dependent nephrotic syndrome. Extensive investigations failed to identify any underlying cause. In keeping with adult reports, rituximab was thought to be the likely cause for this 'late-onset' neutropenia (LOP). He was treated successfully with granulocyte-colony-stimulating factor. Patients treated with rituximab need to be carefully monitored for LOP.
Department of Paediatric Nephrology, Evelina Children's Hospital, London, UK.
Archana A
AA
Kshirsagar
Christopher J D
CJ
Reid
Jayanthi
J
Alamelu
Manish D
MD
Sinha
D058846:Antibodies, Monoclonal, Murine-Derived / Q000009:adverse effects*; D002675:Child, Preschool; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects*; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced* / Q000188:drug therapy; D000069283:Rituximab
D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D016179:Granulocyte Colony-Stimulating Factor; D000069283:Rituximab