Skull-base Ewing sarcoma with multifocal extracranial metastases.
Intracranial occurrence of Ewing sarcoma (ES) is unusual, with a skull-base location being anecdotal. We report a 29-year-old man who presented with rapidly progressive ophthalmoplegia, and was found to be harboring an infiltrative lesion involving the sphenoid sinus, sella, and clivus. He underwent trans-sphenoidal decompression of the lesion which was histologically suggestive of ES. He developed paraparesis 2 weeks after commencing adjuvant therapy. Imaging revealed two thoracic extradural lesions and florid vertebral and pulmonary metastases. This is the first report in indexed literature of a primary intracranial ES on the skull-base with disseminated extracranial disease.
Sumit
S
Thakar
Sunil
S
Furtado
Nandita
N
Ghosal
Jethwani
J
Dilip
Anita
A
Mahadevan
Alangar
A
Hegde
D000328:Adult; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009362:Neoplasm Metastasis; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000473:pathology*; D019292:Skull Base Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014057:Tomography, X-Ray Computed