Synthesis, characterisation and in vitro anticancer activity of hexanuclear thiolato-bridged arene ruthenium metalla-prisms.
Hexanuclear thiolato-bridged arene ruthenium metalla-prisms of the general formula [(p-cymene)(6)Ru(6)(SR)(6)(tpt)(2) ](6+) (R=CH(2)Ph, CH(2)C(6)H(4)-p-tBu, CH(2)CH(2)Ph; tpt=2,4,6-tris(4-pyridyl)-1,3,5-triazine), obtained from the dinuclear precursors [(p-cymene)(2)Ru(2)(SR)(2)Cl(2)], AgCF(3)SO(3) and tpt, have been isolated and fully characterised as triflate salts. The metalla-prisms are highly cytotoxic against human ovarian cancer cells, especially towards the cisplatin-resistant cell line A2780cisR (IC(50) <0.25 μM).
Institute of Chemistry, University of Neuchatel, Ave de Bellevaux 51, 2000 Neuchatel, Switzerland.
Mona A
MA
Furrer
Amine
A
Garci
Emmanuel
E
Denoyelle-Di-Muro
Patrick
P
Trouillas
Federico
F
Giannini
Julien
J
Furrer
Catherine M
CM
Clavel
Paul J
PJ
Dyson
Georg
G
Süss-Fink
Bruno
B
Therrien
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000737:chemistry* / Q000633:toxicity*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D012428:Ruthenium / Q000737:chemistry* / Q000633:toxicity*; D014227:Triazines / Q000737:chemistry
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D014227:Triazines; D012428:Ruthenium; D002945:Cisplatin