Cyclin D1 G870A polymorphism and risk of colorectal cancer: a case control study.
The present study aimed to analyse the role of cyclin D1 A870G polymorphism             in modulating the susceptibility to colorectal cancer (CRC) in the Kashmiri population.             The genotype distribution of the cyclin D1 gene in 130 CRC cases in comparison             with 160 healthy controls was investigated. No direct significant association             between cyclin D1 genotypes and CRC was observed; however, the AG and AA genotypes             were found to be associated with an increased risk of CRC compared to the GG genotype,             with an almost 2-fold increase in OR. This study suggests that the cyclin D1 polymorphism             is associated with an increased risk of CRC in the Kashmiri population.
Department of Immunology and Molecular Medicine, Sher‑I‑Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
Aga Syed
AS
Sameer
Fazl Q
FQ
Parray
Manzoor Ahmad
MA
Dar
Saniya
S
Nissar
Mujeeb Zafar
MZ
Banday
Sabha
S
Rasool
G M
GM
Gulzar
Nissar A
NA
Chowdri
Mushtaq A
MA
Siddiqi
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D019938:Cyclin D1