Role of oxidative stress in refractory epilepsy: evidence in patients and experimental models.
Oxidative stress, a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with systemic diseases, and diseases affecting the central nervous system. Epilepsy is a chronic neurological disorder with refractoriness to drug therapy at about 30%. Currently, experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy. Hence, the aim of this review is to present information in order to facilitate the handling of this evidence and determine the therapeutic impact of the biochemical status for this pathology.
Laboratory of Neurochemistry, National Institute of Pediatrics, 04530, D.F., Mexico. lili_rives@yahoo.com.
Noemi
N
Cardenas-Rodriguez
Bernardino
B
Huerta-Gertrudis
Liliana
L
Rivera-Espinosa
Hortencia
H
Montesinos-Correa
Cindy
C
Bandala
Liliana
L
Carmona-Aparicio
Elvia
E
Coballase-Urrutia
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism; D004195:Disease Models, Animal; D004351:Drug Resistance; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000927:Anticonvulsants; D000975:Antioxidants; D017382:Reactive Oxygen Species