Side effects of corticosteroid injections: what's new?
The risk of sepsis with a hip or knee implant does not seem to be increased by prior joint injections, as long as the injection and surgery are separated by at least two months. Calcifications have been reported after intradiscal injection in the coccygeal region for coccydynia. Complete rest for 24 hours after injection of triamcinolone hexacetonide into the knee had no effect on systemic diffusion of the product. Patients infected by HIV who are treated with ritonavir are at much greater risk for Cushing syndrome after epidural injection. Problems with menstruation after corticosteroid injection seem to be related to a transient decrease in estradiol levels, without alterations in FSH and LH levels. The risk of central serous chorioretinopathy and acute necrosis of the retina after injection is not known, even by ophthalmologists. Transient dysphonia occurs in 12% of patients receiving corticosteroid injections. The impressive Tachon's syndrome seems to be the venous counterpart to Nicolau's syndrome for arteries. Injections into C1-C2 should be abandoned because of the neurological risks. Since serious neurological events after foraminal injections could be the result of an overly fast injection into the arterialized radicular veins rather than in the arteries, only slow injections with products having a low risk of embolism or vascular complications should be allowed. Dexamethasone-based preparations seem to contain no particles or crystals, and have not induced any neurological accidents in various animal models, even after direct administration into vertebral or carotid arteries.
Department of Rheumatology, Hôtel-Dieu, Place Alexis Ricordeau, Nantes University Hospital Center, 44093 Nantes, France. jeanmarie.berthelot@chu-nantes.fr
Jean-Marie
JM
Berthelot
Benoît
B
Le Goff
Yves
Y
Maugars
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000009:adverse effects*; D000818:Animals; D002114:Calcinosis / Q000139:chemically induced / Q000453:epidemiology*; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D004195:Disease Models, Animal; D006801:Humans; D007267:Injections; D009422:Nervous System Diseases / Q000139:chemically induced / Q000453:epidemiology*; D012307:Risk Factors; D018805:Sepsis / Q000139:chemically induced / Q000453:epidemiology*; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives
D000305:Adrenal Cortex Hormones; D003907:Dexamethasone; D014222:Triamcinolone Acetonide; C005900:triamcinolone hexacetonide
Arteries; Dexamethasone; Flare; Flush; Glucocorticoids; Infection; Paraplegia; Steroid injections; Stroke; Tachon's syndrome; Veins