Data assimilation of glucose dynamics for use in the intensive care unit.
We know much about the glucose regulatory system, yet the application of this knowledge is limited because simultaneous measurements of insulin and glucose are difficult to obtain. We present a data assimilation framework for combining sparse measurements of the glucose regulatory system, available in the intensive care unit setting, with a nonlinear computational model to estimate unmeasured variables and unknown parameters. We also demonstrate a method for choosing the best variables for measurement. We anticipate that this framework will improve glucose maintenance therapies and shed light on the underlying biophysical process.
Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. mus236@psu.edu
Madineh
M
Sedigh-Sarvestani
David J
DJ
Albers
Bruce J
BJ
Gluckman
D001786:Blood Glucose / Q000032:analysis*; D006801:Humans; D007328:Insulin / Q000502:physiology; D007362:Intensive Care Units
D001786:Blood Glucose; D007328:Insulin