Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals.
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.
Beijing You'an Hospital, Capital Medical University, Beijing PO 100069, China.
Yong-Hong
YH
Zhang
Yan
Y
Zhao
Ning
N
Li
Yan-Chun
YC
Peng
Eleni
E
Giannoulatou
Rong-Hua
RH
Jin
Hui-Ping
HP
Yan
Hao
H
Wu
Jin-Hua
JH
Liu
Ning
N
Liu
Da-Yan
DY
Wang
Yue-Long
YL
Shu
Ling-Pei
LP
Ho
Paul
P
Kellam
Andrew
A
McMichael
Tao
T
Dong
D000328:Adult; D000483:Alleles; D000914:Antibodies, Viral / Q000097:blood; D044466:Asian People / Q000235:genetics*; D018932:Chemokine CCL2 / Q000097:blood; D002681:China; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000502:physiology; D007251:Influenza, Human / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000821:virology*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D012720:Severity of Illness Index; D055815:Young Adult
D000914:Antibodies, Viral; C111835:CCL2 protein, human; D018932:Chemokine CCL2; C080082:IFITM3 protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins