Challenges in the management of pleomorphic lobular carcinoma in situ of the breast.
BACKGROUND
Pleomorphic Lobular Carcinoma in Situ (PLCIS) is a pathological variant of Lobular Carcinoma in Situ (LCIS) with distinct features. Since first described over a decade ago there are only few papers published about this condition.


METHODS
Medline and Pubmed based literature overview was done with the aim of describing the different histopathological, radiological and clinical features of this pathological entity to highlight the different clinicopathological presentations and modalities of treatment described.


RESULTS
PLCIS has different biological features when compared to LCIS. It is more likely to be associated with invasive disease and the immuno-histochemical profile shows it is less likely to be ER and PR positive with higher positivity of HER2, Ki-67and p53. It has been suggested that PLCIS should be treated more aggressively than LCIS and surgically excised in similar fashion to DCIS.


CONCLUSIONS
PLCIS is a more aggressive variant of LCIS that needs to be managed differently. Surgical excision with clear margins is advised. Further adjuvant treatments have been described in the literature with little evidence to support their use.
Guy's Hospital, Guy's & St Thomas NHS Foundation Trust, Great Maze Pond, London SE1 9RT, United Kingdom.
Yazan A
YA
Masannat
Guy's Hospital, Guy's & St Thomas NHS Foundation Trust, Great Maze Pond, London SE1 9RT, United Kingdom; Section of Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom.
Salena K
SK
Bains
Guy's Hospital, Guy's & St Thomas NHS Foundation Trust, Great Maze Pond, London SE1 9RT, United Kingdom; Section of Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom.
Sarah E
SE
Pinder
Guy's Hospital, Guy's & St Thomas NHS Foundation Trust, Great Maze Pond, London SE1 9RT, United Kingdom; Section of Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom. Electronic address: claire.arnold@kcl.ac.uk.
Arnie D
AD
Purushotham
D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008327:Mammography