The role of miRNA-29 family in cancer.
The miRNA-29 family of microRNAs (miRNAs), including miR-29a, miR-29b and miR-29c, was recently reported to be aberrantly expressed in multiple cancers. Increasing evidence shows that the abnormal expression of miR-29 family is associated with tumorigenesis and cancer progression, making miR-29s a well-analyzed group of miRNAs in cancer research. Here, in this review we aim to provide an overview of the role of miR-29 family in the pathophysiologic changes of cancer cells and the epigenetic and immune regulation through the biological function of miR-29s.
Department of Oncology, Tianjin Medical University, Tianjin, China. hutu120@sina.com
Yang
Y
Wang
Xinwei
X
Zhang
Hui
H
Li
Jinpu
J
Yu
Xiubao
X
Ren
D045744:Cell Line, Tumor; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism
C532045:MIRN29a microRNA, human; D035683:MicroRNAs