The Pneumonia Virus of Mice (PVM) model of acute respiratory infection.
Pneumonia Virus of Mice (PVM) is related to the human and bovine respiratory syncytial virus (RSV) pathogens, and has been used to study respiratory virus replication and the ensuing inflammatory response as a component of a natural host—pathogen relationship. As such, PVM infection in mice reproduces many of the clinical and pathologic features of the more severe forms of RSV infection in human infants. Here we review some of the most recent findings on the basic biology of PVM infection and its use as a model of disease, most notably for explorations of virus infection and allergic airways disease, for vaccine evaluation, and for the development of immunomodulatory strategies for acute respiratory virus infection.
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. kdyer@niaid.nih.gov
Kimberly D
KD
Dyer
Katia E
KE
Garcia-Crespo
Stephanie
S
Glineur
Joseph B
JB
Domachowske
Helene F
HF
Rosenberg
D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D029122:Murine pneumonia virus / Q000276:immunology / Q000472:pathogenicity*; D018186:Pneumovirus Infections / Q000276:immunology / Q000473:pathology*; D012141:Respiratory Tract Infections / Q000276:immunology / Q000473:pathology* / Q000821:virology*