[Biological markers. Utility in the management of patients with pulmonary hypertension].
A biological marker can be defined as any substance that can be objectively measured and evaluated as an indicator of a normal biological process, a pathogenic process or pharmacological responses to a therapeutic intervention. In pulmonary hypertension (PH), in addition to routine markers (hemodynamic and functional), there are a growing number of biomarkers that allow an increasingly comprehensive approach to knowledge of susceptibility to this disease and to diagnosis, prognosis and treatment response. These markers can be both constitutive (genetic) and disease-related (related to right ventricular failure, such as BMP/NT-proBNP, endothelial dysfunction, such as endothelin-1, or inflammation, such as certain cytokines and chemokines). Novel insights in genomics and proteomics may allow major advances in this field.
Unidad de Colagenosis e Hipertensión Pulmonar, Servicio de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla, España. Electronic address: sanchezroman@telefonica.net.
Julio
J
Sánchez Román
María Jesús
MJ
Castillo Palma
Francisco J
FJ
García Hernández
Rocío
R
González León
D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis / Q000235:genetics; D052006:Bone Morphogenetic Protein Receptors, Type II / Q000097:blood / Q000235:genetics; D016207:Cytokines / Q000097:blood; D016232:Endothelins / Q000097:blood; D020022:Genetic Predisposition to Disease; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D020107:Troponin T / Q000097:blood
D015415:Biomarkers; D001798:Blood Proteins; D016207:Cytokines; D016232:Endothelins; D047908:Intracellular Signaling Peptides and Proteins; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; C498218:BMPR2 protein, human; D052006:Bone Morphogenetic Protein Receptors, Type II