Anti-inflammatory diterpenoids from Croton tonkinensis.
Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kaurane-type diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and elastase release.
Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan, Republic of China.
Ping-Chung
PC
Kuo
Mei-Lin
ML
Yang
Tsong-Long
TL
Hwang
Yuan-Yu
YY
Lai
Yue-Chiun
YC
Li
Tran Dinh
TD
Thang
Tian-Shung
TS
Wu
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029802:Croton / Q000737:chemistry; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000187:drug effects / Q000378:metabolism; D013481:Superoxides / Q000037:antagonists & inhibitors / Q000378:metabolism; D014744:Vietnam
D000893:Anti-Inflammatory Agents; D045786:Diterpenes, Kaurane; D013481:Superoxides; D010196:Pancreatic Elastase