Palladium-catalyzed picolinamide-directed alkylation of unactivated C(sp3)-H bonds with alkyl iodides.
We report an efficient method for the alkylation of γ-C(sp(3))-H bonds of picolinamide-protected aliphatic amine substrates with primary alkyl iodides via palladium catalysis. Ag(2)CO(3) and dibenzyl phosphate, (BnO)(2)PO(2)H, are critical promoters of this reaction. These reactions provide a convenient and straightforward method for the preparation of high-value N-containing products from readily available amine and alkyl iodide precursors.
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Shu-Yu
SY
Zhang
Gang
G
He
William A
WA
Nack
Yingsheng
Y
Zhao
Qiong
Q
Li
Gong
G
Chen