Management of tracheobronchial amyloidosis with therapeutic bronchoscopic techniques.
Amyloidosis is a systemic disease caused by abnormal deposition of amyloid material that is detected with Congo red staining and is difficult to diagnose. Involvement of the tracheobronchial tree is rare and is a challenge for pulmonologists because of the wide differential diagnosis of this disease. We present two cases where tracheobronchial affectation has been observed: in one of them as a primary disease, and in another as secondary affectation. The use of bronchoscopic techniques is essential for the diagnosis of tracheobronchial involvement. In the absence of an effective drug therapy, local management of this disease with endoscopic techniques for bronchial repermeabilization is able to provide clinical improvement and expand the treatment options and prognosis in this disease.
Servicio de Neumología, Consorcio Hospital General Universitario de Valencia, Valencia, España. berraondo_@hotmail.com
Javier
J
Berraondo
Laura
L
Novella
Francisco
F
Sanz
Rafael
R
Lluch
Enrique
E
de Casimiro
Tomás
T
Lloret
D000402:Airway Obstruction / Q000209:etiology / Q000601:surgery; D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D001706:Biopsy; D001718:Birefringence; D001853:Bone Marrow / Q000473:pathology; D001982:Bronchial Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D001984:Bronchial Neoplasms / Q000175:diagnosis; D001999:Bronchoscopy / Q000379:methods*; D004396:Coloring Agents; D003131:Combined Modality Therapy; D003224:Congo Red; D003937:Diagnosis, Differential; D005260:Female; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D053685:Laser Therapy; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D014133:Tracheal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*
D004396:Coloring Agents; D003224:Congo Red; D008558:Melphalan; D011241:Prednisone