[Association study between Y-chromosome haplo group and susceptibility to spermatogenisis impairment in Han People from Southwest China].
Idiopathic azoospermia and oligospermia are one of  the most important reasons for male infertility. Abnormal karyotype and azoospermia factor (AZF) microdeletion are two widely acknowledged reasons, but the most causes remain unclear. Y chromosome, as the male-specific chromosome, is closely related to the development of male reproductive system. To understand better the etiology of idiopathic azoospermia and oligospermia, we investigated the possible association between Y-haplogroup distributions and susceptibility to idiopathic azoospermia and severe oligospermia. Peripheral blood was collected from 193 men with normal reproductive history, 193 men with idiopathic azoospermia, and 72 men with idiopathic severe oligospermia. All the subjects underwent karyotyping and AZF deletion analysis to screen out those with AZF deletion and abnormal karyotype. The comparison of Y-haplogroup distribution between experimental group and control group was performed with SPSS V.18.0 software. Significant difference of Y-haplogroup distribution was observed in D1*, F*, K*, N1* and O3*(P=0.032, 0.022, 0.009, 0.009, 0.017, <0.05). The results suggest that Y chromosome haplogroup plays a important role in spermatogenic impairment.
School of Life Sciences, Si-chuan University, Chengdu, China. ran.jing163@gmail.com
Jing
J
Ran
Ting-Ting
TT
Han
Xian-Ping
XP
Ding
Xia
X
Wei
Li-Yuan
LY
Zhang
Yu-Ping
YP
Zhang
Tian-Jun
TJ
Li
Shuang-Shuang
SS
Nie
Lin
L
Chen
D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D053713:Azoospermia / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D002681:China / Q000208:ethnology; D041322:Chromosomes, Human, Y / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D013091:Spermatogenesis; D055815:Young Adult