Regio- and enantioselective aminofluorination of alkenes.
Enantio- and regioselective: The intramolecular enantioselective aminofluorination of unactivated olefins was achieved by using a chiral iodo(III) difluoride salt. A highly regioselective aminofluorination of styrenes to access 2-fluoro-2-phenylethanamines was also developed.
Organic Chemistry Institute, Universität Zürich, Switzerland.
Wangqing
W
Kong
Pascal
P
Feige
Teresa
T
de Haro
Cristina
C
Nevado
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D003500:Cyclization; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D000475:Alkenes; D000588:Amines; D006845:Hydrocarbons, Fluorinated