Trabecular meshwork depigmentation in Vogt-Koyanagi-Harada disease.
OBJECTIVE
Since some patients develop depigmentation of the trabecular meshwork in the course of Vogt-Koyanagi-Harada (VKH) disease, we examined the incidence of trabecular depigmentation and its correlation with other ocular findings and systemic symptoms.


METHODS
We retrospectively reviewed the clinical charts of 53 Japanese patients diagnosed with VKH disease. The scores of trabecular and limbal pigmentation of all patients were recorded. We then examined the correlation between trabecular pigmentation and the presence of sunset glow fundus or skin lesions.


RESULTS
Trabecular pigmentation was significantly lower in the patients with sunset glow fundus than in those without it (P = 0.022), whereas limbal pigmentation showed no significance. However, there were no significant differences in trabecular and limbal pigmentation between the patients with and those without skin lesions. Furthermore, there was no correlation between trabecular and limbal pigmentation.


CONCLUSIONS
Depigmentation of the trabecular meshwork develops in some patients in the course of VKH disease. This depigmentation is significantly correlated with sunset glow fundus, but not with limbal depigmentation or skin lesions.
Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan.
Kazuomi
K
Mizuuchi
Nobuyoshi
N
Kitaichi
Kenichi
K
Namba
Yukihiro
Y
Horie
Susumu
S
Ishida
Shigeaki
S
Ohno
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014129:Trabecular Meshwork / Q000473:pathology; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications* / Q000473:pathology; D055815:Young Adult