Importance of protein dynamics during enzymatic C-H bond cleavage catalysis.
Quantum tunneling and protein dynamics have emerged as important components of enzyme function. This review focuses on soybean lipoxygenase-1, to illustrate how the properties of enzymatic C-H bond activation link protein motions to the fundamental bond making-breaking processes.
Department of Chemistry, Department of Molecular and Cell Biology, and California Institute for Quantitative Biosciences (QB3), University of California , Berkeley, California 94720-3220, United States.
Judith P
JP
Klinman
D019943:Amino Acid Substitution; D002384:Catalysis; D041961:Deuterium Exchange Measurement; D004798:Enzymes / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006860:Hydrogen Bonding; D007700:Kinetics; D008084:Lipoxygenase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D009154:Mutation; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011487:Protein Conformation; D011789:Quantum Theory; D013025:Glycine max / Q000201:enzymology / Q000235:genetics; D013696:Temperature
D004798:Enzymes; D010940:Plant Proteins; C101084:lipoxygenase L-1; D008084:Lipoxygenase