Analysis of transplanted bone marrow-derived cells in chronic pancreatitis.
Pancreatic cancer is a uniformly lethal disease characterized by a strong stromal reaction called desmoplasia. Organ fibrosis is also a feature of chronic pancreatitis a known risk factor for pancreatic cancer. Here we describe a transplantation approach to investigate bone marrow-derived cells in murine models of chronic pancreatitis and pancreatic cancer.
Columbia University Medical Center, New York, NY, USA.
Christoph B
CB
Westphalen
Frederic
F
Marrache
Timothy C
TC
Wang
D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology*; D016026:Bone Marrow Transplantation / Q000379:methods; D002469:Cell Separation; D058948:Cell Tracking; D002108:Ceruletide / Q000009:adverse effects; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D010190:Pancreatic Neoplasms / Q000473:pathology; D050500:Pancreatitis, Chronic / Q000139:chemically induced / Q000473:pathology*; D014916:Whole-Body Irradiation
D002108:Ceruletide