Impact of protein supplementation and care and support on body composition and CD4 count among HIV-infected women living in rural India: results from a randomized pilot clinical trial.
Body composition in HIV-infected individuals is subject to many influences. We conducted a pilot 6-month randomized trial of 68 women living with AIDS (WLA) from rural India. High protein intervention combined with education and supportive care delivered by HIV-trained village women (activated social health activist [Asha] life [AL]) was compared to standard protein with usual care delivered by village community assistants (usual care [UC]). Measurements included CD4 counts, ART adherence, socio-demographics, disease characteristics (questionnaires); and anthropometry (bioimpedance analyzer). Repeated measures analysis of variance modeled associations. AL significantly gained in BMI, muscle mass, fat mass, ART adherence, and CD4 counts compared to UC, with higher weight and muscle mass gains among ART adherent (≥66%) participants who had healthier immunity (CD4 ≥450). BMI of WLA improved through high protein supplementation combined with education and supportive care. Future research is needed to determine which intervention aspect was most responsible.
School of Nursing, University of California at Los Angeles, Room 2-250, Factor Building, Los Angeles, CA 90095-1702, USA. anyamath@sonnet.ucla.edu
Adeline
A
Nyamathi
Sanjeev
S
Sinha
Kalyan K
KK
Ganguly
Padma
P
Ramakrishna
P
P
Suresh
Catherine L
CL
Carpenter
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001823:Body Composition / Q000187:drug effects / Q000276:immunology; D018791:CD4 Lymphocyte Count; D003863:Depression / Q000209:etiology; D004044:Dietary Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D005523:Food Supply; D015658:HIV Infections / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D007194:India; D055118:Medication Adherence; D010353:Patient Education as Topic; D010865:Pilot Projects; D012424:Rural Population; D016896:Treatment Outcome
D019380:Anti-HIV Agents; D004044:Dietary Proteins