Efficient, Low-Cost Synthesis of Retinal (Vitamin A Aldehyde).
Inexpensive retinyl acetate has been subjected to transesterification followed by allylic oxidation to give retinal in 98% yield as a 92:8 mixture of all-trans/13-cis isomers after chromatographic separation. More convenient methods of isolating the all-trans isomer have also been employed.
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Damian P
DP
Hruszkewycz
Kathryn R
KR
Cavanaugh
Kathryn T
KT
Takamura
Lora M
LM
Wayman
Robert W
RW
Curley