Current metabolomics: practical applications.
The field of metabolomics continues to grow rapidly over the last decade and has been proven to be a powerful technology in predicting and explaining complex phenotypes in diverse biological systems. Metabolomics complements other omics, such as transcriptomics and proteomics and since it is a 'downstream' result of gene expression, changes in the metabolome is considered to best reflect the activities of the cell at a functional level. Thus far, metabolomics might be the sole technology capable of detecting complex, biologically essential changes. As one of the omics technology, metabolomics has exciting applications in varied fields, including medical science, synthetic biology, medicine, and predictive modeling of plant, animal and microbial systems. In addition, integrated applications with genomics, transcriptomics, and proteomics provide greater understanding of global system biology. In this review, we discuss recent applications of metabolomics in microbiology, plant, animal, food, and medical science.
Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Sastia P
SP
Putri
Yasumune
Y
Nakayama
Fumio
F
Matsuda
Takato
T
Uchikata
Shizu
S
Kobayashi
Atsuki
A
Matsubara
Eiichiro
E
Fukusaki
D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism; D004331:Drosophila melanogaster / Q000378:metabolism; D005524:Food Technology / Q000639:trends; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism; D055432:Metabolomics / Q000639:trends*; D008829:Microbiology / Q000639:trends; D009369:Neoplasms / Q000378:metabolism; D009422:Nervous System Diseases / Q000378:metabolism; D010944:Plants / Q000378:metabolism; D015027:Zebrafish / Q000378:metabolism