Correlation between the conformation space and the sequence space of Peptide chain.
Effects of point mutations are investigated in a computer model ofsequence selection. In the model, sequences are selected according totheir functional ability defined by the configuration at the active site.Through such functional selection on the local configuration, sequenceswhich fold globally into a unique conformation can be selected from randomsequences. The selected sequence accepts many point mutations as neutralmutations. More structurally fluctuating sites in the chain accept alarger variety of point mutations, which shows correlation between theconformational fluctuation and the sequence fluctuation.
Graduate School of Human Informatics, Nagoya University, Nagoya, 464-8601 Japan.
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Sasaki
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Sasai
functional selection; knowledge-based potential; mutational robustness; neutral evolution; off-lattice model; sequence space; super-funnel