Cerebrospinal fluid (1,3)-β-D-glucan detection as an aid for diagnosis of iatrogenic fungal meningitis.
This case series highlights our experience with use of the Fungitell assay for quantifying (1,3)-β-d-glucan in cerebrospinal fluid during the current U.S. outbreak of fungal meningitis related to contaminated methylprednisolone acetate. This test may prove a useful adjunct in diagnosis and management of exposed patients.
Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jennifer L
JL
Lyons
Karen L
KL
Roos
Kieren A
KA
Marr
Henry
H
Neumann
Julie B
JB
Trivedi
Dorlan J
DJ
Kimbrough
Lisa
L
Steiner
Kiran T
KT
Thakur
Daniel M
DM
Harrison
Sean X
SX
Zhang
D000328:Adult; D000368:Aged; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D004340:Drug Contamination; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D016921:Meningitis, Fungal / Q000175:diagnosis*; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D000077555:Methylprednisolone Acetate; D008875:Middle Aged; D011509:Proteoglycans; D047071:beta-Glucans / Q000134:cerebrospinal fluid*
D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K; D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone