Evaluation of the neurotoxicity of the polyethylene glycol hydrogel dural sealant.
OBJECTIVE
Although polyethylene glycol (PEG) is a neutral, biocompatible hydrophilic     polymer recognized for its lack of interaction with biological barrier, its     neurotoxicity has not been clearly identified in neurosurgery. This study is     constructed to evaluate the possible neurotoxicity of a PEG hydrogel dural     sealant.


METHODS
After a burrhole was opened in the left parietal     bone of the twenty five Wistar albino rats, the dura mater and cerebral cortex     were incised and the experimental material (activated polyethylene glycol and     polyethylene imine) was sprayed into the burrhole. Then brain tissues were     harvested for histopathological and biochemical studies at 72 hours to     investigate the acute stage changes and on 15th day to evaluate the chronic     stage changes.


RESULTS
There were statistically significant differences among     the groups regarding the comparison of the values of the PMNL cell infiltration     grades, gliosis and congestion in both acute and chronic stages. However, the     values of the MNL cell infiltration grades, edema and fibrin formation, lipid     peroxidation levels of harvested brain tissues were similar in all groups.


CONCLUSIONS
Although this study did not present the detailed histopathological     and biochemical evaluation results, it indicated that the application of the     PEG-based hydrogel sealant was not associated with neurotoxicity, delayed     healing, or degenerative changes.
Kirikkale University, Faculty of Medicine, Department of Neurosurgery, Kirikkale, Turkey. bulentbanrs@yahoo.com
Bulent
B
Bakar
Emine Arzu
EA
Kose
Mahi
M
Balci
Pinar
P
Atasoy
Bahram
B
Sarkarati
Aslihan
A
Alhan
Kamer
K
Kilinc
Ismail Semih
IS
Keskil
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000473:pathology; D003399:Craniotomy / Q000379:methods*; D004388:Dura Mater / Q000473:pathology / Q000601:surgery*; D004660:Encephalitis / Q000139:chemically induced / Q000473:pathology; D005911:Gliosis / Q000139:chemically induced / Q000473:pathology; D020100:Hydrogels / Q000633:toxicity*; D023421:Models, Animal; D011092:Polyethylene Glycols / Q000633:toxicity*; D011094:Polyethyleneimine / Q000633:toxicity; D011183:Postoperative Complications / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D014014:Tissue Adhesives / Q000633:toxicity*
D001672:Biocompatible Materials; D020100:Hydrogels; D014014:Tissue Adhesives; D011092:Polyethylene Glycols; D011094:Polyethyleneimine