Isolation, structural elucidation, MS profiling, and evaluation of triglyceride accumulation inhibitory effects of benzophenone C-glucosides from leaves of Mangifera indica L.
Seventy percent ethanol-water extract from the leaves of Mangifera indica L. (Anacardiaceae) was found to show an inhibitory effect on triglyceride (TG) accumulation in 3T3-L1 cells. From the active fraction, six new benzophenone C-glucosides, foliamangiferosides A(3) (1), A(4) (2), C(4) (3), C(5) (4), C(6) (5), and C(7) (6) together with 11 known benzophenone C-glucosides (7-17) were obtained. In this paper,  isolation, structure elucidation (1-6), and  MS fragment cleavage pathways of all  17 isolates were studied. 1-6 showed inhibitory effects on TG and free fatty acid accumulation in 3T3-L1 cells at 10 μM.
Tianjin State Key Laboratory of Modern Chinese Medicine, Nankai District, Tianjin, China.
Yi
Y
Zhang
Lifeng
L
Han
Dandan
D
Ge
Xuefeng
X
Liu
Erwei
E
Liu
Chunhua
C
Wu
Xiumei
X
Gao
Tao
T
Wang
D041721:3T3-L1 Cells; D000818:Animals; D001577:Benzophenones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031022:Mangifera / Q000737:chemistry*; D013058:Mass Spectrometry; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D014280:Triglycerides / Q000378:metabolism*
D001577:Benzophenones; D005960:Glucosides; D010936:Plant Extracts; D014280:Triglycerides; C047723:benzophenone