Subcutaneous and perineural botulinum toxin type a for neuropathic pain: a descriptive review.
OBJECTIVE
Botulinum toxin is a neurotoxin that has been widely used in chronic pain for the treatment of multiple conditions with a component of localized muscle spasm. Recent studies suggest that botulinum toxin is effective in the treatment of neuropathic pain syndromes such as postherpetic neuralgia or painful scars.


METHODS
We searched the PubMed and OvidSP databases. We also included cross-referencing bibliographies from primary and review articles.


CONCLUSIONS
In this descriptive review, we evaluate the usefulness, safety, and potential pathophysiological mechanism of botulinum toxin type A for treatment of painful disorders with neuropathic component such as postherpetic neuralgia, diabetic neuropathy, or trigeminal neuralgia.


CONCLUSIONS
On the basis of the analysis of the reports published in the literature, it would seem that fractioned peripheral subcutaneous and perineural injections of botulinum toxin type A may be useful for the treatment of various chronic pain conditions with neuropathic component.
*Multidisciplinary Pain Management Department †Critical Care and Multidisciplinary Pain Management Department, School of Medicine of Valencia, General University Hospital, Valencia, Spain.
Gustavo
G
Fabregat
José
J
De Andrés
Vicente L
VL
Villanueva-Pérez
Juan M
JM
Asensio-Samper
D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D016208:Databases, Factual / Q000706:statistics & numerical data; D006801:Humans; D007279:Injections, Subcutaneous; D009437:Neuralgia / Q000188:drug therapy*
D019274:Botulinum Toxins, Type A