CoA biosynthesis in archaea.
CoA is a ubiquitous molecule in all three domains of life and is involved in various metabolic pathways. The enzymes and reactions involved in CoA biosynthesis in eukaryotes and bacteria have been identified. By contrast, the proteins/genes involved in CoA biosynthesis in archaea have not been fully clarified, and much has to be learned before we obtain a general understanding of how this molecule is synthesized. In the present paper, we review the current status of the research on CoA biosynthesis in the archaea, and discuss important questions that should be addressed in the near future.
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. atomi@sbchem.kyoto-u.ac.jp
Haruyuki
H
Atomi
Hiroya
H
Tomita
Takuya
T
Ishibashi
Yuusuke
Y
Yokooji
Tadayuki
T
Imanaka
D005075:Biological Evolution; D003065:Coenzyme A / Q000096:biosynthesis*; D010205:Pantothenic Acid / Q000378:metabolism; D010770:Phosphotransferases / Q000378:metabolism; D019712:Thermococcus / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*
D010205:Pantothenic Acid; D010770:Phosphotransferases; D003065:Coenzyme A