[Bone mineral metabolism that kidney controls].
With progressive loss of kidney function, patients with chronic kidney disease develop multiple mineral metabolism abnormalities. Chronic kidney disease-mineral and bone disorder independently associated with cardiovascular disease and mortality. FGF23 which discovered in late years gave us new knowledge to elucidate these mechanisms. Further elucidation of FGF23-Klotho will help us to improve the understanding of pathogenesis of bone mineral metabolism abnormality.
Department of Medicine, Tokai University, Japan.
Genta
G
Kanai
Masafumi
M
Fukagawa
D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism
C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23