[Pharmacovigilance update].
Main pharmacovigilance updates in 2012 are reviewed here. Dabigatran: elderly patients with renal failure are at higher risk of bleeding. Dual renin-angiotensin-aldosterone system blockade comprising aliskiren is harmful. Incretins: low risk of acute pancreatitis. Interaction between fusidic acid and statins: many reports of rhabdomyolysis. Interactions between boceprevir/telaprevir and antiretroviral therapies: complex, but manageable. Citalopram, ondansetron: maximum recommended doses are reduced. Atomoxetine: significant increase in blood pressure and heart rate in a fraction of exposed patients. Agomelatine: elevated liver enzymes are common. Fingolimod: bradycardia and heart blocks after first dose - stronger safety recommendations regarding use in patients with heart conditions and strengthened cardiovascular monitoring.
Division de pharmacologie clinique, Département des laboratoires, CHUV, 1011 Lausanne. francoise.livio@chuv.ch
F
F
Livio
D018759:Adrenergic Uptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D000367:Age Factors; D000368:Aged; D000577:Amides / Q000009:adverse effects / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use; D000069445:Atomoxetine Hydrochloride; D001562:Benzimidazoles / Q000009:adverse effects / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology; D000069604:Dabigatran; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000209:etiology; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use; D005650:Fumarates / Q000009:adverse effects / Q000627:therapeutic use; D006470:Hemorrhage / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D060735:Pharmacovigilance; D011437:Propylamines / Q000009:adverse effects / Q000627:therapeutic use; D015091:beta-Alanine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use
D018759:Adrenergic Uptake Inhibitors; D000577:Amides; D000959:Antihypertensive Agents; D001562:Benzimidazoles; D005343:Fibrinolytic Agents; D005650:Fumarates; D011437:Propylamines; D015091:beta-Alanine; C446481:aliskiren; D000069445:Atomoxetine Hydrochloride; D000069604:Dabigatran