Selectivity of ligand-receptor interactions between nanoparticle and cell surfaces.
Selectivity of interactions between nanoparticles functionalized by tethered ligands and cell surfaces with different densities of receptors plays an essential role in biorecognition and its implementation in nanobiomedicine. We show that the onset of nanoparticle adsorption has a universal character for a range of nanoparticles: the onset receptor density decreases exponentially with the energy of ligand-receptor binding and inversely with the ligand density. We demonstrate that a bimodal tether distribution, which permits shielding ligands by longer nonfunctional tethers, leads to extra loss of entropy at the adsorption onset, enhancing the selectivity.
Department of Macromolecular Science and Engineering, Case Western Reserve University, 2100 Adelbert Road, Cleveland, Ohio 44106-7202, USA.
Shihu
S
Wang
Elena E
EE
Dormidontova
D003198:Computer Simulation; D008024:Ligands; D008954:Models, Biological; D008958:Models, Molecular; D009010:Monte Carlo Method; D053758:Nanoparticles / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000378:metabolism*; D013816:Thermodynamics
D008024:Ligands; D011956:Receptors, Cell Surface