[Quality evaluation of domestic Echinacea extracts].
OBJECTIVE
To determine the content of polyphenol contained samples, in order to provide basis for comprehensive quality evaluation on Echinacea extracts.


METHODS
LC-MS was used for qualitative analysis on relevant compounds of the samples of Echinacea extracts. Optimized USP methods, RP-HPLC and QAMS (quantitative analysis of multi-components by single-marker) were used to determine the content of polyphenol. Meanwhile, UV method was adopted for comparative analysis on content according to international standard IS014502-1-2005.


RESULTS
The six batches of samples could not meet the export standard for polyphenol content by HPLC. UV showed four batches in line with the standard and two batches in inconformity.


CONCLUSIONS
UV method is generally adoptedfor the content determination of domestic Echinacea extracts, but shows results that are significantly different from that by HPLC method. it is suggested to use HPLC method to standardize quality of extracts and raise market access standards.
Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China. anshiying@126.com
Shi-Ying
SY
An
Yu-Mei
YM
Hu
Hong-Wei
HW
Miao
Zhao-Qing
ZQ
Meng
Pei-Xiang
PX
Wang
Gang
G
Ding
Zhen-Zhong
ZZ
Wang
Wei
W
Xiao
D002681:China; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000592:standards; D020900:Echinacea / Q000737:chemistry*; D011786:Quality Control
D004365:Drugs, Chinese Herbal