Laser enhanced high-intensity focused ultrasound thrombolysis: an in vitro study.
Laser-enhanced thrombolysis by high intensity focused ultrasound (HIFU) treatment was studied in vitro with bovine blood clots. To achieve laser-enhanced thrombolysis, laser light was employed to illuminate the sample concurrently with HIFU radiation, and ultrasound and laser parameters were optimized to achieve better thrombolysis efficiency. The results indicated that the thrombolysis efficiency increased when pulse length of HIFU wave, HIFU pressure, or laser fluence increases. Also, with the presence of laser, an enhanced effect of thrombolysis was observed.
KU Bioengineering Research Center, Department of Mechanical Engineering, University of Kansas, Lawrence, Kansas 66045, USA. hzhcui@ku.edu
Huizhong
H
Cui
Xinmai
X
Yang
D000818:Animals; D002417:Cattle; D005240:Feasibility Studies; D057086:High-Intensity Focused Ultrasound Ablation / Q000295:instrumentation*; D007834:Lasers; D061185:Mechanical Thrombolysis / Q000295:instrumentation* / Q000379:methods; D011312:Pressure; D013927:Thrombosis / Q000097:blood / Q000628:therapy*