Vimentin is a component of a complex that binds to the 5'-UTR of human heme-regulated eIF2α kinase mRNA and regulates its translation.
The human heme-regulated eIF2α kinase, also called the human heme-regulated inhibitor (hHRI) is significantly up-regulated particularly at the level of translation during stress. In this report we show that during lead-stress, the regulation of hHRI mRNA translation is mediated through its 5'-untranslated region (UTR) that interacts with specific trans-acting factors. Further, vimentin has been identified as one of the trans-acting factors that contribute to this regulation.
Cell and Molecular Biology Laboratory, Department of Biotechnology, University of Pune, Pune 411007, India.
Sangeeta
S
Chatterjee
Amaresh C
AC
Panda
Sunil K
SK
Berwal
R K
RK
Sreejith
Charu
C
Ritvika
Vasudevan
V
Seshadri
Jayanta K
JK
Pal
D020121:5' Untranslated Regions; D002460:Cell Line; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D006801:Humans; D049409:Luciferases, Firefly / Q000096:biosynthesis / Q000235:genetics; D009942:Organometallic Compounds / Q000494:pharmacology; D011485:Protein Binding; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism; D013312:Stress, Physiological; D015854:Up-Regulation; D014746:Vimentin / Q000378:metabolism* / Q000502:physiology; D019892:eIF-2 Kinase / Q000235:genetics* / Q000378:metabolism
D020121:5' Untranslated Regions; D009942:Organometallic Compounds; D012333:RNA, Messenger; D012261:Ribonucleoproteins; D014746:Vimentin; D049409:Luciferases, Firefly; D019892:eIF-2 Kinase; C008261:lead acetate