Acute differential effects of dietary protein quality on postprandial lipemia in obese non-diabetic subjects.
Non-fasting triglyceridemia is much closer associated to cardiovascular risk compared to fasting triglyceridemia. We hypothesized that there would be acute differential effects of four common dietary proteins (cod protein, whey isolate, gluten, and casein) on postprandial lipemia in obese non-diabetic subjects. To test the hypothesis we conducted a randomized, acute clinical intervention study with crossover design. We supplemented a fat rich mixed meal with one of four dietary proteins i.e. cod protein, whey protein, gluten or casein. Eleven obese non-diabetic subjects (age: 40-68, body mass index: 30.3-42.0 kg/m(2)) participated and blood samples were drawn in the 8-h postprandial period. Supplementation of a fat rich mixed meal with whey protein caused lower postprandial lipemia (P = .048) compared to supplementation with cod protein and gluten. This was primarily due to lower triglyceride concentration in the chylomicron rich fraction (P = .0293). Thus, we have demonstrated acute differential effects on postprandial metabolism of four dietary proteins supplemented to a fat rich mixed meal in obese non-diabetic subjects. Supplementation with whey protein caused lower postprandial lipemia compared to supplementation with cod and gluten. As postprandial lipemia is closely correlated to cardiovascular disease, long-term dietary supplementation with whey protein may prove beneficial in preventing cardiovascular disease in obese non-diabetic subjects.
Department of Endocrinology and Metabolism, MEA, Aarhus University Hospital, Aarhus C, Denmark. holmer-jensen@ki.au.dk
Jens
J
Holmer-Jensen
Lene S
LS
Mortensen
Arne
A
Astrup
Michael
M
de Vrese
Jens J
JJ
Holst
Claus
C
Thomsen
Kjeld
K
Hermansen
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002364:Caseins / Q000008:administration & dosage; D018592:Cross-Over Studies; D003920:Diabetes Mellitus; D004044:Dietary Proteins / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000209:etiology; D008019:Life Style; D008297:Male; D062407:Meals; D008875:Middle Aged; D008894:Milk Proteins / Q000008:administration & dosage; D009765:Obesity / Q000097:blood* / Q000150:complications; D019518:Postprandial Period / Q000187:drug effects*; D014280:Triglycerides / Q000097:blood; D000067816:Whey Proteins
D001786:Blood Glucose; D002364:Caseins; D004044:Dietary Proteins; D005230:Fatty Acids, Nonesterified; D008894:Milk Proteins; D014280:Triglycerides; D000067816:Whey Proteins; D005983:Glutens