Nonhuman targets in allergic lung conditions.
Existing therapies for allergic asthma are far from perfect: the global prevalence of disease increases despite them and they are poorly effective in dealing with the exacerbations that account for hospitalization and asthma deaths. Commercially, there are pressures on these existing medicines too--a growing threat from generics and reluctance by payers to reimburse for increasingly marginal improvements in medicines with precedented mechanisms. Experience shows that attempts to devise selective small-molecule interventions directed at the myriad of downstream effector pathways has not been a fertile ground for the development of effective new medicines. An alternative strategy, exploiting breakthroughs in understanding the molecular basis of allergenicity and the key role of innate immune mechanisms in asthma, is to direct new approaches to the disease triggers themselves: allergens. This raises interesting possibilities for anti-Lipinski drug design (extracellular nonhuman targets, inhaled delivery) and creates unprecedented pharmacological opportunities in the therapeutic area.
Division of Biomedical Sciences, St George's, University of London, UK. c.robinson@sgul.ac.uk
Clive
C
Robinson
Jihui
J
Zhang
Gary K
GK
Newton
Trevor R
TR
Perrior
D000485:Allergens / Q000276:immunology / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000378:metabolism; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D008969:Molecular Sequence Data; D011485:Protein Binding / Q000276:immunology; D017433:Protein Structure, Secondary
D000485:Allergens; D018927:Anti-Asthmatic Agents