Sensor integration of multiple tripolar concentric ring electrodes improves pentylenetetrazole-induced seizure onset detection in rats.
As epilepsy affects approximately one percent of the world population, electrical stimulation of the brain has recently shown potential for additive seizure control therapy. Previously, we applied noninvasive transcranial focal stimulation via tripolar concentric ring electrodes on the scalp of rats after inducing seizures with pentylenetetrazole. We developed a system to detect seizures and automatically trigger the stimulation and evaluated the system on the electrographic activity from rats. In this preliminary study we propose and validate a novel seizure onset detection algorithm based on exponentially embedded family. Unlike the previously proposed approach it integrates the data from multiple electrodes allowing an improvement of the detector performance.
Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, RI 02881, USA. omakeyev@ele.uri.edu
Oleksandr
O
Makeyev
Quan
Q
Ding
Steven M
SM
Kay
Walter G
WG
Besio
D000465:Algorithms; D000818:Animals; D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D004569:Electroencephalography / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012640:Seizures / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D012680:Sensitivity and Specificity; D018511:Systems Integration; D014159:Transducers
D010433:Pentylenetetrazole