Gene expression in self-repressing system with multiple gene copies.
We analyze a simple model of a self-repressing system with multiple gene copies. Protein molecules may bound to DNA promoters and block their own transcription. We derive analytical expressions for the variance of the number of protein molecules in the stationary state in the self-consistent mean-field approximation. We show that the Fano factor (the variance divided by the mean value) is bigger for the one-gene case than for two gene copies and the difference decreases to zero as frequencies of binding and unbinding increase to infinity.
Institute of Applied Mathematics and Mechanics, University of Warsaw, Banacha 2, 02-097 Warsaw, Poland. miekisz@mimuw.edu.pl
Jacek
J
Miekisz
Paulina
P
Szymańska
D018628:Gene Dosage; D005786:Gene Expression Regulation; D008957:Models, Genetic; D009716:Numerical Analysis, Computer-Assisted; D013269:Stochastic Processes; D014158:Transcription, Genetic