[Research progress of conserved non-coding elements in metazoan].
In addition to protein coding sequence, the organism genome contains a significant amount of regulatory DNA. Comparative genomics reveals that the organism genomes of vertebrates, tunicate, cephalochordate, flies, and nematodes contain cis-regulatory elements with highly conserved non-coding elements (CNEs). CNEs that cluster around trans-dev genes are part of core gene regulatory networks (GRNs), and usually, they can act as transcriptional enhancers. In this review, we described the identification of CNEs and summarized their key properties across the metazoans, and then discussed the evolution of CNEs after large-scale genome duplication events and the role of CNEs in the evolution of ani-mal body plan.
School of life science, Xiamen University, Xiamen, China. junvon@126.com
Jun
J
Feng
Guang
G
Li
Yi-Quan
YQ
Wang
D000818:Animals; D003062:Codon; D017124:Conserved Sequence; D019143:Evolution, Molecular; D006801:Humans; D007448:Invertebrates / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D014714:Vertebrates / Q000235:genetics*
D003062:Codon; D011506:Proteins