Anatomical evidence of microbial biofilms in an alloplastic nasal implant.
Recently, bacterial biofilms have been proposed as a potential cause of the extreme resistance to antibiotics and impaired host responses in potentially infected facial implants. As opposed to the bacteria in a free-floating or planktonic state, biofilms exist in a sessile form, adherent to a solid or liquid interface and become embedded in a complex matrix that is oftentimes impenetrable to modern day antibiotics. This can lead to chronic infection of implants which ultimately necessitates their removal in a majority of cases. In this novel case report, we show the histomorphological appearance of biofilm formation in a patient with an alloplastic nasal implant that was persistently infected and had to be removed.


METHODS
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Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, 660 S. Euclid Ave., CB 8115, St. Louis, MO 63110, USA. desais@ent.wustl.edu
Shaun C
SC
Desai
Arash
A
Moradzadeh
Gregory
G
Branham
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018441:Biofilms; D020878:Device Removal; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015508:Nasal Obstruction / Q000175:diagnosis / Q000209:etiology; D009300:Nasal Septum / Q000601:surgery*; D019736:Prostheses and Implants / Q000382:microbiology; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000382:microbiology; D012086:Reoperation; D012225:Rhinoplasty / Q000009:adverse effects* / Q000379:methods; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000503:physiopathology; D013211:Staphylococcus aureus / Q000502:physiology*; D014184:Transplantation, Homologous; D055815:Young Adult
D000900:Anti-Bacterial Agents