Different mutations of the human c-mpl gene indicate distinct haematopoietic diseases.
The human c-mpl gene (MPL) plays an important role in the development of megakaryocytes and platelets as well as the self-renewal of haematopoietic stem cells. However, numerous MPL mutations have been identified in haematopoietic diseases. These mutations alter the normal regulatory mechanisms and lead to autonomous activation or signalling deficiencies. In this review, we summarise 59 different MPL mutations and classify these mutations into four different groups according to the associated diseases and mutation rates. Using this classification, we clearly distinguish four diverse types of MPL mutations and obtain a deep understand of their clinical significance. This will prove to be useful for both disease diagnosis and the design of individual therapy regimens based on the type of MPL mutations.
Department of Hematology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Xin
X
He
Zhigang
Z
Chen
Yangyan
Y
Jiang
Xi
X
Qiu
Xiaoying
X
Zhao
D006402:Hematologic Diseases / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D053628:Receptors, Thrombopoietin / Q000235:genetics*; D015398:Signal Transduction
D053628:Receptors, Thrombopoietin; C082218:MPL protein, human