Choroidal thickness and biometric markers for the screening of lacquer cracks in patients with high myopia.
OBJECTIVE
Validation of choroidal thickness and other biometrics measured by spectral domain optical coherence tomography (SD-OCT) in predicting lacquer cracks formation in highly myopic eyes.


METHODS
Patients with a refractive error worse than -8 diopters and moderate myopic maculopathy were recruited into two groups based on the presence or absence of lacquer cracks (36 eyes without and 33 eyes with lacquer cracks). Choroidal thickness, refractive error, and axial length were measured and subjected to receiver operating characteristic curve analysis to identify the optimal cutoff values at predicting lacquer crack formation. The width of the retinal pigment epithelium (RPE), RPE to the inner segment/outer segment line, RPE to the external limiting membrane were also measured and compared to the subfoveal choroidal thickness to assess their relationships as potential markers of lacquer crack formation.


RESULTS
Lacquer crack is associated with decreased choroidal thickness, lower best-corrected visual acuity, longer axial length and higher refractive errors. Choroidal thickness has the strongest association with lacquer crack formation versus axial length and refractive error. In eyes with lacquer cracks, stellate lacquer cracks are associated with thinner choroidal thickness compared to eyes with linear lacquer cracks. Subfoveal choroidal thickness less than the width of the retinal pigment epithelium to the inner segment/outer segment line is also associated with lacquer crack formation (sensitivity 78.8%, specificity 88.3%, and accuracy 81.2%).


CONCLUSIONS
This study suggests that choroidal thickness and other SD-OCT measurements could be employed clinically to predict the development and severity of lacquer cracks in patients with high myopia.
Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. wang.nankai@gmail.com
Nan-Kai
NK
Wang
Chi-Chun
CC
Lai
Chai Lin
CL
Chou
Yen-Po
YP
Chen
Lan-Hsin
LH
Chuang
An-Ning
AN
Chao
Hsiao-Jung
HJ
Tseng
Chee-Jen
CJ
Chang
Wei-Chi
WC
Wu
Kuan-Jen
KJ
Chen
Stephen H
SH
Tsang
D015415:Biomarkers; D001699:Biometry / Q000379:methods*; D002829:Choroid / Q000473:pathology*; D006801:Humans; D009216:Myopia / Q000175:diagnosis / Q000473:pathology*; D012449:Safety; D041623:Tomography, Optical Coherence / Q000009:adverse effects
D015415:Biomarkers