Volumetric detection of colorectal lesions for noncathartic dual-energy computed tomographic colonography.
Noncathartic computed tomographic colonography (CTC) could significantly increase patient adherence to colorectal screening guidelines. However, radiologists find the interpretation of noncathartic CTC images challenging. We developed a fully automated computer-aided detection (CAD) scheme for assisting radiologists with noncathartic CTC. A volumetric method is used to detect lesions within a thick target region encompassing the colonic wall. Dual-energy CTC (DE-CTC) is used to provide more detailed information about the colon than what is possible with conventional CTC. False-positive detections are reduced by use of a random-forest classifier. The effect of the thickness of the target region on detection performance was assessed by use of 22 clinical noncathartic DE-CTC studies including 27 lesions ≥6 mm. The results indicate that the thickness parameter can have significant effect on detection accuracy. Leave-one-patient-out evaluation indicated that the proposed CAD scheme detects colorectal lesions at high accuracy in noncathartic CTC.
Department of Radiology of Harvard Medical School, 25 New Chardon Street, Suite 400C, Boston, MA 02114, USA. jnappi@partners.org
Janne J
JJ
Näppi
Se Hyung
SH
Kim
Hiroyuki
H
Yoshida
D002400:Cathartics / Q000008:administration & dosage / Q000494:pharmacology; D003106:Colon / Q000000981:diagnostic imaging / Q000473:pathology; D023881:Colonography, Computed Tomographic / Q000379:methods*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging*; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D005189:False Positive Reactions; D006801:Humans; D011860:Radiography, Abdominal
D002400:Cathartics