A novel enzyme-catalyzed synthesis of N-substituted pyrrole derivatives.
A novel method for the synthesis of substituted pyrroles catalyzed by α-amylase from hog pancreas via Paal-Knorr reaction was developed. A series of pyrrole derivatives were synthesized under mild conditions and the products were obtained with good to excellent yields (60-99 %). The impact of factors, such as solvents, enzyme amount, and temperature, on the reaction were investigated. This study reports an efficient route for the synthesis of N-substituted pyrrole derivatives.
College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China. huizheng@hznu.edu.cn
Hui
H
Zheng
Qiaoyue
Q
Shi
Kui
K
Du
Yijia
Y
Mei
Pengfei
P
Zhang
D000818:Animals; D055162:Biocatalysis; D010179:Pancreas / Q000737:chemistry* / Q000201:enzymology; D011758:Pyrroles / Q000138:chemical synthesis*; D012997:Solvents; D013552:Swine; D013696:Temperature; D000516:alpha-Amylases / Q000737:chemistry* / Q000302:isolation & purification
D011758:Pyrroles; D012997:Solvents; D000516:alpha-Amylases