IFPA Gabor Than Award lecture: molecular control of placental growth: the emerging role of microRNAs.
Fetal growth is dependent on appropriate growth and function of the placenta. This is modulated by a variety of factors, including maternal growth factors that exert their actions by binding to specific receptors on trophoblast to promote activation of signaling events. Kinases and phosphatases within trophoblast act in concert to regulate growth factor actions and recent studies have begun to elucidate a role for microRNAs (miRs) in regulating the levels of these proteins in the placenta. This review will discuss growth factor signaling in the placenta and describe the emerging role of miRs in regulating placental development.
Maternal & Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester M13 0JH, United Kingdom. karen.forbes@manchester.ac.uk
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Forbes
D001363:Awards and Prizes; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology*; D010920:Placenta / Q000378:metabolism; D010929:Placentation / Q000187:drug effects / Q000235:genetics*; D011247:Pregnancy; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
D036341:Intercellular Signaling Peptides and Proteins; D035683:MicroRNAs