Dynamics of Bio-Polymeric Brushes Growing from a Cellular Membrane: Tentative Modelling of the Actin Turnover within an Adhesion Unit; the Podosome.
Podosomes are involved in the adhesion process of various cells to a solid substrate. They have been proven to consist of a dense actin core surrounded by an actin cloud. The podosomes, which nucleate when the cell comes in the vicinity of a substrate, contribute to link the membrane to the solid surface, but rather than frozen links, collective dynamical behaviors are experimentally observed. Depending on the differentiation stage, podosomes assemble and form clusters, rings or belts. Considering the dynamics of a polymeric brush, we design a simple model aiming at the description of a single podosome, the basic unit of these complex adhesion-structures and compare our theoretical conclusions to recent experimental results. Particularly, we explain, by solving the diffusion problem around the podosome, why the structure is likely to have a finite life-span.
Laboratoire de Spectometrie Physique, CNRS UMR 5588, Universite Joseph Fourier, 140 Avenue de la Physique, 38402 Saint Martin d'Heres, France.
Thierry
T
Biben
Jean-Christophe
JC
Géminard
Francisco
F
Melo
actin turnover; podosome; polymeric brush