Investigation of the heating properties of platinum nanoparticles under a radiofrequency current.
OBJECTIVE
For the potential application of platinum nanoparticles (PtNPs) in hyperthermia therapy, the heating efficiency of PtNPs in the presence of radiofrequency (RF) current generated by a capacitive electric transfer (CET) system was compared with that of gold nanoparticles (AuNPs).


METHODS
PtNPs and AuNPs synthesised by citrate capping (5 nm) were exposed to an RF current of 0.35 ± 0.05 MHz in a CET system. The temperature of the solution containing various concentrations of platinum or gold NPs was monitored for 5 min at various power ranges.


RESULTS
When both NP solutions were exposed to an RF field at a fixed power, the temperature of the NP solution increased continuously over the 5 min of measurement. In contrast, the NP-free solutions did not show any temperature change. Both PtNPs and AuNPs can be heated in a concentration- and power-dependent manner. However, PtNPs showed a higher efficiency in generating heat compared with AuNPs in both water and the physiological buffer.


CONCLUSIONS
The heat generating efficiency of 5-nm PtNPs was about 50% higher than that of AuNPs when they were exposed to electric current through RF. This result suggests that PtNPs are promising nanomaterials for RF-induced hyperthermia therapy.
Sungkyunkwan Advanced Institute of Nanotechnology, Sungkyunkwan University, Suwon, Korea.
Boi Hoa
BH
San
Sang Hyun
SH
Moh
Kyeong Kyu
KK
Kim
D006046:Gold; D006361:Heating; D006358:Hot Temperature; D006979:Hyperthermia, Induced / Q000379:methods; D053768:Metal Nanoparticles; D010984:Platinum; D011846:Radio Waves
D010984:Platinum; D006046:Gold