Toxicity and cosmesis following partial breast irradiation consisting of 40 Gy in 10 daily fractions.
OBJECTIVE
To assess the toxicity and cosmetic results in breast cancer patients undergoing adjuvant partial breast irradiation (PBI) to a total dose of 40 Gy in 10 daily fractions (4 Gy/fraction).


METHODS
Patients affected by early-stage breast cancer were enrolled in this phase II trial. Patients had to be 60 years old and treated with breast conservative surgery for early stage (pT1-T2 pN0-N1a) invasive ductal carcinoma.


RESULTS
77 patients were enrolled. Median follow-up was 18 months. The proposed schedule was well tolerated. One patient reported Grade 3 pain at the site of irradiation. Four (5%) patients experience Grade 2 erythema. Late Grade 2 and 1 fibrosis was observed in 3 (4%) and 14 (18%) patients, respectively. Cosmesis was judged "good/excellent" and "poor" in 75 (97%) and in 2 (3%) patients, respectively.


CONCLUSIONS
40 Gy in 10 daily fractions, 4 Gy/fraction, is a well tolerated regimen to deliver PBI.
Department of Radiation Oncology, Centro di Riferimento Oncologico of Aviano, via F. Gallini 2, 33081 Aviano (PN), Italy. Electronic address: marcotrovo33@hotmail.com.
Marco
M
Trovo
Mario
M
Roncadin
Jerry
J
Polesel
Erica
E
Piccoli
Mario
M
Mileto
Elvia
E
Micheli
Tiziana
T
Perin
Antonino
A
Carbone
Samuele
S
Massarut
Mauro G
MG
Trovo
D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000473:pathology* / Q000528:radiation effects* / Q000601:surgery; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000532:radiotherapy* / Q000601:surgery; D019583:Dose Fractionation, Radiation; D004890:Erythema / Q000209:etiology; D005260:Female; D005355:Fibrosis / Q000209:etiology; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods
Breast cancer; Cosmesis; Hypofractionation; Partial breast irradiation; Toxicity