Recombinant human bone morphogenetic protein 2 in lateral ridge augmentation.
This case report describes the augmentation of severe lateral ridge defects in the maxilla and mandible using recombinant human bone morphogenetic protein 2 (rhBMP-2) on an absorbable collagen sponge (ACS). The surgical technique used tenting screws and a membrane to maintain space for the ACS. After 7 months of healing, the ridge width increased from 1 to 2 mm to 6 to 9 mm, thus allowing successful placement of dental implants. De novo bone formation through use of the surgical technique for space maintenance of rhBMP-2/ACS was demonstrated without the need for additional particulate bone grafting.
Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA. robert_mehanna@hsdm.harvard.edu
Robert
R
Mehanna
Samuel
S
Koo
David M
DM
Kim
D020341:Absorbable Implants; D016301:Alveolar Bone Loss / Q000601:surgery; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D055396:Bone Morphogenetic Protein 2 / Q000627:therapeutic use*; D001863:Bone Screws; D015921:Dental Implants; D004337:Drug Carriers; D005260:Female; D005781:Gelatin Sponge, Absorbable; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery*; D008437:Maxilla / Q000601:surgery*; D008567:Membranes, Artificial; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology; D021362:Palate, Hard / Q000293:injuries / Q000601:surgery; D011994:Recombinant Proteins / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D014945:Wound Healing / Q000502:physiology
D055396:Bone Morphogenetic Protein 2; D015921:Dental Implants; D004337:Drug Carriers; D008567:Membranes, Artificial; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2