Mesenchymal and stem-like cell properties targeted in suppression of chronically-induced breast cell carcinogenesis.
Stem-like cells and the epithelial-to-mesenchymal transition (EMT) program are postulated to play important roles in various stages of cancer development, but their roles in breast cell carcinogenesis and intervention remain to be clarified. We investigated stem-like cell- and EMT-associated properties and markers in breast epithelial cells chronically exposed to low-dose 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene in the presence and absence of the preventive agents green tea catechins and grape seed extract. Our results indicate that stem-like cell- and EMT-associated properties and markers should be seriously considered as new cancer-associated indicators for detecting breast cell carcinogenesis and as endpoints for intervention of carcinogenesis.
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996, USA.
Kusum
K
Rathore
Hwa-Chain Robert
HC
Wang
D001564:Benzo(a)pyrene / Q000633:toxicity; D001943:Breast Neoplasms / Q000517:prevention & control*; D002392:Catechin / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects*; D005260:Female; D056604:Grape Seed Extract / Q000494:pharmacology; D006801:Humans; D009602:Nitrosamines / Q000633:toxicity; D044945:Proanthocyanidins / Q000494:pharmacology; D013234:Stem Cells / Q000187:drug effects* / Q000502:physiology; D013662:Tea
D056604:Grape Seed Extract; C511402:Grape Seed Proanthocyanidins; D009602:Nitrosamines; D044945:Proanthocyanidins; D013662:Tea; D001564:Benzo(a)pyrene; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; D002392:Catechin