Invasive pulmonary aspergillosis due to Emericella nidulans var. echinulata, successfully cured by voriconazole and micafungin.
A 78-year-old male who was undergoing prolonged glucocorticoid treatment experienced cough and expectoration for 2 weeks. Galactomannan antigen analysis and a chest computed tomography (CT) scan suggested a diagnosis of invasive pulmonary aspergillosis. DNA sequencing indicated that Emericella nidulans var. echinulata was the causative agent. A combination of voriconazole and micafungin successfully treated the illness.
Department of Dermatology and Venereology, Peking University First Hospital, Peking University, Beijing, China. yujin676@gmail.com
Jin
J
Yu
Xiangdong
X
Mu
Ruoyu
R
Li
D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D054714:Echinocandins / Q000008:administration & dosage*; D032842:Emericella / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D005122:Exudates and Transudates / Q000382:microbiology; D005690:Galactose / Q000031:analogs & derivatives; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D016867:Immunocompromised Host; D055744:Invasive Pulmonary Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D055666:Lipopeptides / Q000008:administration & dosage*; D008297:Male; D008351:Mannans / Q000032:analysis; D000077551:Micafungin; D008853:Microscopy; D008969:Molecular Sequence Data; D011743:Pyrimidines / Q000008:administration & dosage*; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole
D000935:Antifungal Agents; D004271:DNA, Fungal; D054714:Echinocandins; D005938:Glucocorticoids; D055666:Lipopeptides; D008351:Mannans; D011743:Pyrimidines; D014230:Triazoles; C012990:galactomannan; D065819:Voriconazole; D000077551:Micafungin; D005690:Galactose