An efficient one-pot organocatalyzed synthesis of spiro[chroman-3,6'- furo[2,3-d]pyrimidine]-tetraones.
An efficient synthesis of new spiro[chroman-3,6'-furo[2,3-d]pyrimidine]- tetraones by an organocatalyzed three-component condensation reaction of aldehydes, barbituric acids and 3-bromo-4-hydroxy-2H-chromen-2-one in refluxing acetic acid in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is reported. We are hopeful that the products will lead to a wider range pharmacological and physiological activity.
Department of Chemistry, Shahid Beheshti University, General Campus, Tehran 1983963113, Iran.
Somayeh
S
Ahadi
Peiman
P
Mirzaei
Ayoob
A
Bazgir
D019342:Acetic Acid / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D001463:Barbiturates / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D015394:Molecular Structure; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D000447:Aldehydes; D001463:Barbiturates; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011744:Pyrimidinones; D013141:Spiro Compounds; C031033:1,8-diazabicyclo(5.4.0)undec-7-ene; D019342:Acetic Acid; C032232:barbituric acid