Does sildenafil contribute to acute coronary thrombosis?
Sildenafil was the first oral compound to be approved for the treatment of erectile dysfunction. It is a selective inhibitor of isoform 5 of phosphodiesterase, which is the enzyme responsible for the breakdown of 3', 5'-cyclic guanosine mono-phosphate. Sildenafil-associated myocardial infarction (MI) is rarely seen in patients without previous history of coronary artery disease. A 43-year-old man presented with sudden onset of chest pain. It was determined that his chest pain started after sildenafil intake. Findings consistent with acute anterior MI were observed on electrocardiography. Coronary angiography showed total occlusion of left anterior descending artery with thrombosis. Coronary angioplasty and stenting was successfully performed.
Department of Cardiology, Ada Medical Hospital, Sakarya, Turkey. ersantatli@yahoo.com.
Ersan
E
Tatlı
Mehmet Akif
MA
Çakar
Emir
E
Doğan
Mustafa
M
Alkan
D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003328:Coronary Thrombosis; D007172:Erectile Dysfunction; D006801:Humans; D009203:Myocardial Infarction; D000068677:Sildenafil Citrate
D000068677:Sildenafil Citrate