Histological examination of expanded polytetrafluoroethylene artificial dura mater at 14 years after craniotomy: case report.
Expanded polytetrafluoroethylene (ePTFE) porous material (GORE(®) PRECLUDE(®) Dura Substitute) does not degenerate or deteriorate in vivo, and is currently used as artificial dura mater. This material does not adhere well to the surrounding tissues, but cerebrospinal fluid leakage along the suture line has been observed in several cases. We describe a case of craniotomy for tumor resection performed 14 years after dural repair with ePTFE sheet. Histological examination of the ePTFE sheet revealed that the sheet was structurally intact, with no evidence of tissue adhesion or cellular infiltration. However, collagen deposition was observed around the suture thread. When the suture thread was removed the collagen was also removed, and the original needle hole appeared again. No significant changes were observed in the features of the ePTFE sheet even 14 years postoperatively. The formation of fibrous tissue around the needle hole was important in preventing cerebrospinal fluid leakage.
Department of Neurosurgery, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan. kazekawa@xb3.so-net.ne.jp
Yoshihisa
Y
Matsumoto
Hiroshi
H
Aikawa
Masanori
M
Tsutsumi
Sumito
S
Narita
Hidenori
H
Yoshida
Housei
H
Etou
Kimiya
K
Sakamoto
Kiyoshi
K
Kazekawa
D000368:Aged; D065634:Cerebrospinal Fluid Leak; D002559:Cerebrospinal Fluid Rhinorrhea / Q000473:pathology* / Q000517:prevention & control*; D003094:Collagen / Q000648:ultrastructure*; D003399:Craniotomy; D004388:Dura Mater / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000601:surgery*; D008579:Meningioma / Q000473:pathology* / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000473:pathology* / Q000517:prevention & control*; D012086:Reoperation; D013537:Sutures; D000267:Tissue Adhesions
D011138:Polytetrafluoroethylene; D003094:Collagen