Pestaloficiols Q-S from the plant endophytic fungus Pestalotiopsis fici.
Two new isoprenylated chromone derivatives, pestaloficiols Q (1) and R (2), and one new benzofuran derivative, pestaloficiol S (3), along with three known metabolites, anofinic acid (4), siccayne (5), and pyrenophorol (6) were isolated from solid cultures of the plant endophytic fungus Pestalotiopsis fici. Their structures were elucidated primarily by NMR spectroscopy, and the absolute of the C-6 secondary alcohol in 1 was deduced on the basis of circular dichroism (CD) data. Compound 5 showed cytotoxic activity against the human cancer cell lines, HeLa and HT29, with IC50 values of 48.2 and 33.9μM, respectively.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.
Shuchun
S
Liu
Liangdong
L
Guo
Yongsheng
Y
Che
Ling
L
Liu
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D001203:Ascomycota / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D060026:Endophytes / Q000737:chemistry*; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure
D000970:Antineoplastic Agents; D001572:Benzofurans; D002867:Chromones