Drug carriers for oral delivery of peptides and proteins: accomplishments and future perspectives.
Effective formulation for peptide and protein delivery through the oral route has always been the critical effort with the advent of biotechnology. Stability, enzymatic degradation and ineffective absorption are common difficulties found for conventional dosage forms. As a result, new drug-delivery approaches are used to circumvent these limitations and enhance effective oral drug delivery. Some of these technologies have reached late stages of clinical trials and promising results will be available in the near future. This review covers, in general, the recent carriers reported in literature.
Universidade Lusófona (CBIOS - Laboratory of Nanoscience & Biomedical Nanotechnology), Campo Grande 376, 1749-024 Lisboa, Portugal. catarina.reis@ulusofona.pt
Catarina Pinto
CP
Reis
Catarina
C
Silva
Nuno
N
Martinho
Catarina
C
Rosado
D000284:Administration, Oral; D000818:Animals; D001709:Biotechnology / Q000379:methods; D002986:Clinical Trials as Topic; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D010455:Peptides / Q000008:administration & dosage*; D011506:Proteins / Q000008:administration & dosage*
D004337:Drug Carriers; D010455:Peptides; D011506:Proteins