Thrombophilia in Patients With Lower Limb Deep Veins Thrombosis (LDVT) Results of a Monocentric Survey on 103 Consecutive Outpatients.
A debate concerns the utility of large screening for acquired or inherited thrombophilia. The study concerns relationship between inherited thrombophilic status and lower limb deep vein thrombosis (LDVT) and highlights the possible use of extensive thrombophilia screening to determine an emerging risk of LDVT. From January 2010 to January 2012, 103 consecutive patients with LDVT were considered. In all, 57 (55.3%) patients with LDVT showed inherited thrombophilia. The most frequent trombophilic alterations were deficiency of protein S (33 patients, 32.0%), methylentethrafolate reductase (MTHFR) gene C677T variant (22 patients, 21.4%), protrombin gene G20210A alteration (50, 14.6%), and deficiency of protein C (12, 11.6%). Age and MTHFR variant were found related to LDVT and thrombophilia was related to distal LDVT. A high frequency of thrombophylic factor was found in patients with LDVT, but we believe that a generic genetic screening should not be suggested for these patients.
Department of Medical and Pediatric Science, University of Catania, Medical Angiology Unit Hospital Garibaldi, Catania, Italy ssignore@unict.it.
Salvatore Santo
SS
Signorelli
Department of Medical and Pediatric Science, University of Catania, Medical Angiology Unit Hospital Garibaldi, Catania, Italy.
Valerio
V
Fiore
Department of Medical and Pediatric Science, University of Catania, Medical Angiology Unit Hospital Garibaldi, Catania, Italy.
Giuseppe
G
Puccia
Department of Medical and Pediatric Science, University of Catania, Medical Angiology Unit Hospital Garibaldi, Catania, Italy.
Gianluca
G
Mastrosimone
Department of Medical and Pediatric Science, University of Catania, Medical Angiology Unit Hospital Garibaldi, Catania, Italy.
Massimiliano
M
Anzaldi
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D035002:Lower Extremity; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D020151:Protein C Deficiency / Q000097:blood / Q000150:complications / Q000235:genetics; D018455:Protein S Deficiency / Q000097:blood / Q000150:complications / Q000235:genetics; D011516:Prothrombin / Q000235:genetics / Q000378:metabolism; D012189:Retrospective Studies; D012307:Risk Factors; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology / Q000235:genetics
D011516:Prothrombin; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
MTHFR; coagulative screening; deep vein thrombosis; thrombophilia