Metachronous malignant mesothelioma and pulmonary adenocarcinoma.
The prevalence of multiple primary malignant neoplasms in a single patient is     reported in a wide variation. The co-existence of malignant mesothelioma and     pulmonary carcinoma is a rare entity. Herein, we reported a 60-year-old man who     was a retired employee and heavy smoker. He had a suspicious history of asbestos     exposure. He complained of chest pain and computerized tomography revealed a     mass in the lower lobe of left lung. The patient underwent a left lower     lobectomy and was diagnosed as pulmonary adenocarcinoma. During follow-up two     years after surgery, the patient complained of dyspnea and chest computerized     tomography scan revealed right pleural effusion and diffuse pleural thickening.     For the differential diagnosis, the patient underwent wedge biopsy from the     right lower lobe and was diagnosed as epithelial diffuse malignant mesothelioma.     The development of malignant pleural mesothelioma and lung carcinoma could be     associated with asbestos exposure. However, a history of asbestos exposure is     not required for the diagnosis. The influence of effective anticancer therapies     that improve the survival rates and increase the population ages could be     related to the occurrence of a second malignancy.
Department of Pathology, Akdeniz University, Faculty of Medicine, Antalya, Turkey. iremhicrang@hotmail.com
İrem Hicran
İH
Özbudak
Ömer
Ö
Özbudak
Gökhan
G
Arslan
Abdullah
A
Erdoğan
Gülay
G
Özbılım
D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D001194:Asbestos / Q000009:adverse effects; D001706:Biopsy; D015897:Comorbidity; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D011013:Pneumonectomy; D014057:Tomography, X-Ray Computed
D001194:Asbestos