Recombinant influenza vaccines.
This review covers the problems encountered in the construction and production of new recombinant influenza vaccines. New approaches to the development of influenza vaccines are investigated; they include reverse genetics methods, production of virus-like particles, and DNA- and viral vector-based vaccines. Such approaches as the delivery of foreign genes by DNA- and viral vector-based vaccines can preserve the native structure of antigens. Adenoviral vectors are a promising gene-delivery platform for a variety of genetic vaccines. Adenoviruses can efficiently penetrate the human organism through mucosal epithelium, thus providing long-term antigen persistence and induction of the innate immune response. This review provides an overview of the practicability of the production of new recombinant influenza cross-protective vaccines on the basis of adenoviral vectors expressing hemagglutinin genes of different influenza strains.
Gamaleya Research Institute of Epidemiology and Microbiology, Gamaleya Str., 18, Moscow, Russia, 123098.
E S
ES
Sedova
D N
DN
Shcherbinin
A I
AI
Migunov
Iu A
IuA
Smirnov
D Iu
DIu
Logunov
M M
MM
Shmarov
L M
LM
Tsybalova
B S
BS
Naroditskiĭ
O I
OI
Kiselev
A L
AL
Gintsburg
Recombinant vaccine; immunization; influenza