Taxol: efficacy against oral squamous cell carcinoma.
In medicinal chemistry, one of the most studied molecules in recent history is taxol. Taxol is a versatile natural product that is used in various cancer treatment regimens. It is administered to patients with breast, lung, and ovarian cancers, and is currently being studied for the treatment of squamous cell carcinoma of the oral cavity and tongue. Taxol has been tested in a number of research and clinical phase trials to determine feasibility, toxicity, and cytotoxicity against oral squamous cell carcinoma as a single drug regimen and as a contributing drug component in treatment plans. This paper reviews over forty articles that examine cell lines, murine models, and human results for the response of taxol against squamous cell carcinoma (SCC) of the oral cavity and the tongue.
Chemistry Department, Valdosta State University, Valdosta Ga. 31698, USA.
Kaitlyn
K
Ledwitch
Ryenne
R
Ogburn
Jodi
J
Cox
Rebekah
R
Graham
Allison
A
Fritzsche
Donna
D
Gosnell
Thomas
T
Manning
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality; D002470:Cell Survival / Q000187:drug effects; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000401:mortality; D017239:Paclitaxel / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D017671:Platinum Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000401:mortality
D000972:Antineoplastic Agents, Phytogenic; D017671:Platinum Compounds; D017239:Paclitaxel