Association of ophthalmic complications in patients with sulfur mustard induced mild ocular complications and serum soluble adhesion molecules: Sardasht-Iran Cohort Study.
The aim of this study was to evaluate possible association between ophthalmic complications in sulfur mustard (SM) exposed patients with mild ocular injuries and serum soluble adhesion molecules. Serum levels of sICAM-1, sL-selectin, sP-selectin and sE-selectin in 367 SM-exposed individuals with or without eye injuries were checked and compared with 128 unexposed controls. All participants underwent ocular examinations. Serum sICAM-1 level in SM exposed with blurred vision, was significantly (p=0.021) higher than in SM exposed with no blurred vision. Serum sL-selectin level was significantly (p=0.024) higher in SM exposed with photophobia than SM exposed with no photophobia. Serum P-selectin level in exposed without any slit lamp findings was significantly (p=0.003) lower than the matched control groups. Similar finding was seen in exposed group without ocular problem compared with the control groups. Serum sE-selectin level in exposed with normal ocular condition except for photophobia and blurred vision was significantly (p<0.05) higher than the matched controls. Serum E-selectin level in exposed with photophobia condition was significantly (p=0.047) higher than the control group with photophobia. In conclusion it seems that the changes in the E- and P-selectins is a regulatory mechanism for inhibition of SM induced ocular problems, although the local levels are more important and further investigations required in more severe ocular problems in SM exposed patients.
Immunoregulation Research Center, Shahed University, Tehran, Islamic Republic of Iran; Department of Ophthalmology, Shahed University, Tehran, Islamic Republic of Iran.
Hassan
H
Ghasemi
Roya
R
Yaraee
Zuhair Mohammad
ZM
Hassan
Soghrat
S
Faghihzadeh
Mohammad-Reza
MR
Soroush
Shahriar
S
Pourfarzam
Massoumeh
M
Ebtekar
Mahmoud
M
Babaei
Sakine
S
Moaiedmohseni
Mohammad-Mehdi
MM
Naghizadeh
Nayere
N
Askari
Tooba
T
Ghazanfari
D002619:Chemical Warfare Agents / Q000633:toxicity*; D015331:Cohort Studies; D005128:Eye Diseases / Q000097:blood* / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007492:Iran / Q000453:epidemiology; D009151:Mustard Gas / Q000633:toxicity*; D019087:Selectins / Q000097:blood*
D002619:Chemical Warfare Agents; C573420:ICAM1 protein, human; D019087:Selectins; D018799:Intercellular Adhesion Molecule-1; D009151:Mustard Gas
E-selectin; ICAM-1; L-selectin; Ocular injury; P-selectin; Sulfur mustard