[Nephrotic syndrome after treatment with d-penicillamine in a pediatric patient with Wilson's disease].
We describe a case of nephrotic syndrome (NS) after a 7 months treatment with D-penicillamine in a 14 years old girl with Wilson's disease, with a prompt regression at the discontinuation of the drug. Kidney function, proteinuria in particular, must be always monitored during the chelating therapy, and the drug must be discontinued as soon as signs of renal injury are detected.
U.O. Pediatria 2, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano.
M
M
Farallo
C
C
Amoruso
C
C
Frattini
G
G
Ardissino
G
G
Nebbia
D000293:Adolescent; D002614:Chelating Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D009404:Nephrotic Syndrome / Q000139:chemically induced*; D010396:Penicillamine / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors; D016896:Treatment Outcome; D019345:Zinc Acetate / Q000008:administration & dosage
D002614:Chelating Agents; D019345:Zinc Acetate; D010396:Penicillamine