Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides Mat Salleh.
Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC(50)value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC(50) of 0.207 µM.
Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia. rosalindkim@hotmail.com
Rosalind Pei Theng
RP
Kim
Vicky
V
Bihud
Khalit
K
Bin Mohamad
Kok Hoong
KH
Leong
Jamaludin
J
Bin Mohamad
Fasihuddin
F
Bin Ahmad
Hazrina
H
Hazni
Noraini
N
Kasim
Siti Nadiah Abdul
SN
Halim
Khalijah
K
Awang
D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001060:Aporphines / Q000302:isolation & purification / Q000494:pharmacology; D001549:Benzamides / Q000302:isolation & purification / Q000494:pharmacology; D002934:Cinnamates / Q000302:isolation & purification / Q000494:pharmacology; D054335:Goniothalamus / Q000737:chemistry*; D019073:HT29 Cells; D006571:Heterocyclic Compounds / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*; D011714:Pyrans / Q000302:isolation & purification / Q000494:pharmacology; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology
D000975:Antioxidants; D001060:Aporphines; D001549:Benzamides; D002934:Cinnamates; D006571:Heterocyclic Compounds; D007783:Lactones; D010936:Plant Extracts; D011714:Pyrans; D011753:Pyrones; D012717:Sesquiterpenes; C541898:pterodondiol; C073078:9-deoxygoniopypyrone; C029010:cinnamic acid; C103280:goniothalamin; C037689:benzamide; C026980:liriodenine