Evaluation of the effects of the use of platelet-rich plasma (PRP) on alveolar bone repair following extraction of impacted third molars: prospective study.
Platelet-rich plasma (PRP) is rich in growth factors, target-specific polypeptides that play a role in cell proliferation and differentiation and can thus encourage wound repair. This study sought to assess the effects of PRP on new bone formation in a sample of 25 patients with clinical indications for extraction of all four impacted third molars with similar orientation, depth, and root morphology. Immediately after extraction, sockets on one side received PRP, whereas those on the other side (control) did not. Patients underwent 6 months of clinical and radiographic follow-up. Periapical radiographs were scanned and bone repair was assessed by image histogram analysis. The radiographic densities of the extraction sockets were compared to the densities of the distal surfaces of the adjacent teeth, with the difference between both serving to distinguish the PRP and control sides. Results showed that healing of PRP-treated sockets was significantly different from that of control sockets at 1-, 3-, and 6-month follow-up, in mandibular and maxillary sockets alike. The results of this sample suggest that PRP provides a safe and effective means of speeding alveolar bone repair.
Faculdade de Odontologia, Universidade Federal de Pelotas, Rua Gomes Carneiro, 1, Centro, CEP 96010-610, Pelotas, RS, Brazil. gantonello@hotmail.com
Guilherme de Marco
Gde M
Antonello
Ricardo
R
Torres do Couto
Caroline Comis
CC
Giongo
Marcos Britto
MB
Corrêa
Otacílio Luiz
OL
Chagas Júnior
Carmen Helena Jacques
CH
Lemes
D000293:Adolescent; D000328:Adult; D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000473:pathology*; D015519:Bone Density / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology; D008437:Maxilla / Q000000981:diagnostic imaging / Q000473:pathology; D008964:Molar, Third / Q000601:surgery*; D010012:Osteogenesis / Q000502:physiology*; D010976:Platelet Count; D053657:Platelet-Rich Plasma / Q000502:physiology*; D011446:Prospective Studies; D016300:Radiography, Bitewing / Q000379:methods; D019252:Radiography, Dental, Digital / Q000379:methods; D013917:Thrombin / Q000627:therapeutic use; D014081:Tooth Extraction; D020390:Tooth Socket / Q000000981:diagnostic imaging / Q000473:pathology; D014095:Tooth, Impacted / Q000601:surgery*; D055815:Young Adult
D013917:Thrombin