Direct site-selective arylation of enamides via a decarboxylative cross-coupling reaction.
An efficient Pd-catalyzed decarboxylative cross-coupling reaction of simple enamides was achieved. Depending on the choice of the nitrogen-protecting group, a site-selective synthesis of mono- or diarylated framework(s) was performed under mild conditions. This unprecedented reactivity could be applied to the synthesis of a range of 2- or 2,4-diarylated nitrogen-containing bioactive derivatives.
Institut de Chimie Organique et Analytique, UMR 7311 CNRS, rue de Chartres, Université d'Orléans, F-45067 Orléans Cedex 2, France.
Nicolas
N
Gigant
Laëtitia
L
Chausset-Boissarie
Isabelle
I
Gillaizeau
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D017672:Nitrogen Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
D000577:Amides; D017672:Nitrogen Compounds; D010165:Palladium