[Study of oral precancerous lesion and oral cancer by using micro PET/CT].
OBJECTIVE
To study oral precancerous lesion and oral cancer by using micro PET/CT.


METHODS
Thirty-nine SD rats were divided into experimental group and control group. 33 of them were raised with a 4-nitroquinoline-1-oxide (4NQO) solution with the concentration of 0.002% during the first 13 weeks, and then changed to normal water. The other 6 rats drank normal water all the time. During 25th to 30th week of the experiment, 2-Deoxy-2-[F-18]fluoro-D-glucose (FDG)-PET/CT was performed for these rats. One day after imaging, pathological examination was performed. SUVmax and T/NT were investigated according to pathological results. SAS6.0 software package was used for statistical analysis.


RESULTS
There was no significant difference in SUVmax among the normal group, precancerous group and cancerous group (P>0.05). There was significant difference in T/NT(muscle, brain) between the normal group and the cancerous group (P<0.05). But there was no significant difference between the normal group and the precancerous group (P>0.05); and no significant difference between the precancerous group and the cancerous group (P>0.05). The T/NT (muscle, brain) ratios increased along with the increase of the pathologic grade of the lesions. There was no significant difference in T/NT(thyroid) among the three groups and no correlation between the T/NT(thyroid) ratios and the pathologic grade.


CONCLUSIONS
Micro PET/CT, as a non-invasive technology, may contribute to the dynamic studies of the process of carcinogenesis. T/NT(muscle, brain) ratios could show the degree of lesions of rat's tongue during carcinogenesis.
Department of Oral Medicine, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China. josefcl@yahoo.com.cn
Liang
L
Chen
Shu-yun
SY
Ge
Han-qing
HQ
Li
Hai-wen
HW
Zhou
D000818:Animals; D019788:Fluorodeoxyglucose F18; D009062:Mouth Neoplasms; D049268:Positron-Emission Tomography; D011230:Precancerous Conditions; D019275:Radiopharmaceuticals; D051381:Rats; D017207:Rats, Sprague-Dawley; D014057:Tomography, X-Ray Computed
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18