Rapid eye movement sleep behavior disorder in adults younger than 50 years of age.
Rapid eye movement (REM) sleep behavior disorder (RBD) occurring prior to age 50 is termed early-onset RBD. Early-onset RBD comprises a substantial minority of cases, and demonstrates the differences in demographics, comorbidities, and clinical considerations from previously described typical RBD with onset >50years. The world literature on RBD is reviewed with specific focus on features that distinguish early-onset RBD, including more gender parity, increased proportion of idiopathic cases, increased proportion of cases associated with narcolepsy, parasomnia overlap disorder, antidepressants, and possibly autoimmune disorders, and clinical presentation.
Department of Neurology, Washington University in Saint Louis, Saint Louis, MO, USA. juy@neuro.wustl.edu
Yo-El S
YE
Ju
D017677:Age Distribution; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000453:epidemiology; D003866:Depressive Disorder / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000453:epidemiology* / Q000503:physiopathology*; D020447:Parasomnias / Q000453:epidemiology / Q000503:physiopathology; D020187:REM Sleep Behavior Disorder / Q000453:epidemiology* / Q000503:physiopathology*; D017678:Sex Distribution
D000928:Antidepressive Agents
Antidepressant; Autoimmune; Narcolepsy; Parasomnia; Parasomnia overlap disorder (POD); REM sleep behavior disorder (RBD)