Modeling normal and rebound excitation in mammalian retinal ganglion cells.
In this study, we used a novel missing currents technique to extend an existing conductance-based ionic current model of retinal ganglion cells (RGCs). The revised model reproduced a variety of biological behaviors. In particular, the model contains a hyperpolarization activated current (I(h)). This model can effectively simulate the mechanisms underlying both normal and rebound action potentials. The technique used in this study is generally applicable to other excitable cell models, reducing the gap between theoretical models and real biological neurons.
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, 2052, Australia.
Tianruo
T
Guo
David
D
Tsai
Gregg J
GJ
Suaning
Nigel H
NH
Lovell
Socrates
S
Dokos
D000818:Animals; D008564:Membrane Potentials; D008954:Models, Biological; D018408:Patch-Clamp Techniques; D011817:Rabbits; D012165:Retinal Ganglion Cells / Q000166:cytology*