S100+ cells: a new neuro-immune cross-talkers in lymph organs.
Up to now, the 'hardwired' neural pathway of the neuro-immune regulation is not fully understood. Here we reported a new neural pathway which links sympathetic nerves with immune cells of the lymphoid tissues. Our results demonstrated that nerve fibers derived from superior cervical ganglion directly targeted only S100(+) cells in the cervical lymph nodes. Moreover, we found co-expression of neurotransmitters such as norepinephrine, vasoactive intestinal polypeptide and neuropeptide Y in the postganglionic sympathetic nerve endings that innervate S100(+) cells. Our findings suggested that S100(+) cells serve as a neuro-immune cross-talker in lymph organs that may play a significant role in transmitting signals of nervous cells to targeted immune cells. The new findings provide better understanding of the cross-talk mechanism between the nervous system and the immune system.
Department of Anatomy, Medical College of Soochow University, Suzhou 215123, Jiangsu Province, China.
Jinyu
J
Huang
Chunfang
C
Zhu
Peipei
P
Zhang
Qian
Q
Zhu
YanMei
Y
Liu
Zhansheng
Z
Zhu
MinChen
M
Wang
Wenjie
W
Li
Gang
G
Yang
Nan
N
Dong
Juan
J
Liu
Lian
L
Chen
Yanlin
Y
Zhang
Runlin
R
Yang
Lili
L
Deng
Jun
J
Fan
Xiaochun
X
Wang
Jun
J
Liu
Bin
B
Ma
Qiang
Q
Fu
Kaiyun
K
Wu
D000818:Animals; D007107:Immune System / Q000276:immunology* / Q000294:innervation* / Q000378:metabolism; D008198:Lymph Nodes / Q000276:immunology / Q000294:innervation* / Q000378:metabolism; D008208:Lymphatic System / Q000276:immunology* / Q000294:innervation* / Q000378:metabolism; D008297:Male; D009411:Nerve Endings / Q000276:immunology / Q000378:metabolism; D009412:Nerve Fibers / Q000276:immunology* / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000276:immunology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000276:immunology / Q000378:metabolism
D018377:Neurotransmitter Agents