[Research progress studies on pharmacology and pharmacokinetics of ligustilide].
Ligustilide is contained highly or around 1% in such umbelliferous plants as Angelica sinensis and Ligusticum chuanxiong, is one of main bioactive constituents. It shows many pharmacological activities related to their efficacy. At present, ligustilide has attracted extensive attention and more and more studies have been reported, indicating that it is a promising compound. This essay summarizes the progress of pharmacological effects of ligustilide on neuroprotection, vasodilatation, anti-caner and anti-tumor, analgesia and anti-inflammation, and pharmacokinetics including absorption, distribution, metabolism and excretion, providing basis for further studies and development of ligustilide.
Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023, China.
Ai-Hua
AH
Zuo
Li
L
Wang
Hong-Bin
HB
Xiao
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D030004:Ligusticum / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; C027820:ligustilide; D015107:4-Butyrolactone