SYNTAX score is a predictor of angiographic no-reflow in patients with ST-elevation myocardial infarction treated with a primary percutaneous coronary intervention.
OBJECTIVE
The no-reflow phenomenon has a negative prognostic value in patients with acute ST-elevation myocardial infarction (STEMI). The SYNTAX score (SS) quantifies the extent and complexity of angiographic disease and predicts long-term mortality and morbidity in STEMI. We aimed to assess the no-reflow and its possible relationships with SS and clinical characteristics in patients with STEMI treated with a primary percutaneous coronary intervention (PPCI).


METHODS
In this study, 880 patients with STEMI treated with PPCI were included prospectively (646 men and 234 women, mean age 58.5±12.4 years). The SS, thrombolysis in myocardial infarction (TIMI) flow grade score, and TIMI myocardial blush grade score were determined in all patients. No-reflow was defined as TIMI grade 0, 1 and 2 flows or TIMI grade 3 with myocardial blush grade 0 and 1. The patients were divided into two groups: a normal flow group and a no-reflow group.


RESULTS
No-reflow was observed in 32.8% of patients. The mean SS of the no-reflow group was higher than that of the normal flow group (19.2±6.8/12.9±6.1, P<0.001). On multivariate logistic regression analysis, SS [β=0.872, 95% confidence interval (CI)=0.845-0.899, P<0.001], diabetes (β=0.767, 95% CI=0.128-4.597, P=0.004), anterior myocardial infarction (β=5.421, 95% CI=1.369-21.469, P=0.025), and thrombus grade after wiring (β=2.537, 95% CI=1.506-4.273, P<0.001) were found to be independent predictors of no-reflow. The cutoff value of SS obtained by the receiver-operator characteristic curve analysis was 19.75 for the prediction of no-reflow (sensitivity: 70.6%, specificity: 69.4%).


CONCLUSIONS
The SS is a predictor of no-reflow in patients with STEMI treated with PPCI.
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey. dysahin79@hotmail.com
Durmuş Y
DY
Şahin
Mustafa
M
Gür
Zafer
Z
Elbasan
Osman
O
Kuloğlu
Taner
T
Şeker
Ali
A
Kivrak
İbrahim H
İH
Tanboğa
Gökhan
G
Gözübüyük
Sinan
S
Kirim
Murat
M
Çayli
D000367:Age Factors; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D023921:Coronary Stenosis / Q000000981:diagnostic imaging; D003328:Coronary Thrombosis / Q000145:classification / Q000000981:diagnostic imaging; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000628:therapy*; D054318:No-Reflow Phenomenon; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D012372:ROC Curve; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index