Glycated albumin is a potential diagnostic tool for diabetes mellitus.
Using a community-based population cross-sectional study, we investigated the validity of an enzymatic method for glycated albumin (GA) measurements and evaluated its utility as a diagnostic tool for diabetes mellitus (DM). In total, 1,211 participants from the city of Harbin, People's Republic of China, were enrolled in the study. A receiver operating characteristic (ROC) analysis for GA, fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) measurements in diagnosed and undiagnosed DM were compared, based on a definition of DM using 1999 WHO criteria. We also estimated the correlation among GA, HbA1c and other clinical characteristics. Significant and positive correlations of fasting serum GA with FPG (r = 0.8097) and HbA1c (r = 0.8976) were found in participants enrolled in the study. ROC analysis for GA predicting undiagnosed DM with a cut-off point of 15.7% was similar to that of FPG and HbA1c. Therefore, our data indicate that GA is a potential tool for DM diagnosis.
Department of Clinical Biochemistry Laboratory, The 4th affiliated Hospital of Harbin Medical University, Harbin, China.
Chun
C
Yang
Hanbin
H
Li
Zhihai
Z
Wang
Wanying
W
Zhang
Kun
K
Zhou
Jianhua
J
Meng
Ying
Y
Zhao
Jing
J
Pan
Xiaofeng
X
Lv
Hongyan
H
Liang
Xiaofeng
X
Jiang
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D017127:Glycation End Products, Advanced; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012709:Serum Albumin / Q000378:metabolism*; D055815:Young Adult; D000093423:Glycated Serum Albumin
D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin