Small molecule disruption of B. subtilis biofilms by targeting the amyloid matrix.
Small molecule inhibitors of amyloid aggregation have potential as treatment for a variety of conditions. In this issue of Chemistry & Biology, Romero and colleagues use amyloid-dependent B. subtilis biofilm formation to screen for amyloid inhibitors, identifying compounds that not only inhibit B. subtilis biofilm formation but also ones that disrupt preformed biofilms.
Department of Chemistry, Umeå University, 90187 Umeå, Sweden.
Emma K
EK
Andersson
Matthew
M
Chapman