Testing of Perilla frutescens extract and Vicenin 2 for their antispasmodic effect.
Gastrointestinal discomfort is frequently observed. The effects of Perilla frutescens extract and Vicenin 2 (a compound in this extract) were assayed in rat ileum with or without stimulation with acetylcholine or Ba(2+). Both had no direct spasmolytic effect, but both decreased acetylcholine- or Ba(2+)-induced contraction of rat ileum indicating an antispasmodic effect. This is valuable because effects were only observed when spasms were induced and may disturb the patient. The extract and the compound may be used to maintain and improve gut health.
Department of Pharmacology, Institute of Medicinal Chemistry, University of Münster, Münster, Germany. verspoh@uni-muenster.de
Eugen J
EJ
Verspohl
Hajime
H
Fujii
Kohei
K
Homma
Sybille
S
Buchwald-Werner
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D047310:Apigenin / Q000737:chemistry / Q000494:pharmacology*; D017609:Barium Compounds / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005260:Female; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D031344:Perilla frutescens / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats
D017609:Barium Compounds; D002712:Chlorides; D005960:Glucosides; D010276:Parasympatholytics; D010936:Plant Extracts; C530449:apigenin-6,8-di-C-glycopyranoside; C024986:barium chloride; D047310:Apigenin; D000109:Acetylcholine