Carbon monoxide form of PEGylated hemoglobin protects myocardium against ischemia/reperfusion injury in diabetic and normal mice.
We investigated the pre-clinical utility of carbon monoxide form of PEGylated hemoglobin (PEG-Hb also named SANGUINATE(™)) in myocardial infarction (MI) and in particular the response of diabetic tissues to superimposed ischemia/reperfusion injury. SANGUINATE(™) was evaluated in diabetic and normal mice subjected to 30 min of coronary artery ligation followed by either 48 h or 28 days of reperfusion. Our results demonstrate that SANGUINATE(™) was effective in reducing infarct size when administered either prior to left anterior descending coronary artery (LAD) occlusion or during reperfusion. This finding is an important step in exploring the efficacy of a pharmacoinvasive strategy using SANGUINATE(™) in patients with acute coronary syndromes.
Department of Medicine, Diabetes Research Program, New York University Langone Medical Center, New York , NY , USA.
Radha
R
Ananthakrishnan
Qing
Q
Li
Karen M
KM
O'Shea
Nosirudeen
N
Quadri
Lingjie
L
Wang
Abraham
A
Abuchowski
Ann Marie
AM
Schmidt
Ravichandran
R
Ramasamy
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001802:Blood Substitutes / Q000737:chemistry / Q000494:pharmacology; D002248:Carbon Monoxide / Q000737:chemistry* / Q000494:pharmacology*; D048909:Diabetes Complications / Q000378:metabolism / Q000517:prevention & control*; D004734:Energy Metabolism / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006454:Hemoglobins / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D009203:Myocardial Infarction / Q000150:complications / Q000378:metabolism / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D018384:Oxidative Stress / Q000187:drug effects; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology*; D013997:Time Factors
D015415:Biomarkers; D001802:Blood Substitutes; D006454:Hemoglobins; C109960:PEG-hemoglobin; D011092:Polyethylene Glycols; D002248:Carbon Monoxide