Randomized controlled trial of the effect of 30% versus 80% fraction of inspired oxygen on cesarean delivery surgical site infection.
OBJECTIVE
To determine if supplemental perioperative oxygen will reduce surgical site infection (SSI) following cesarean delivery.


METHODS
This is a randomized, controlled trial evaluating SSI following either 30% or 80% fraction of inspired oxygen (FIO2) during and 2 hours after cesarean delivery. Anesthesia providers administered FIO2 via a high-flow oxygen blender. Subjects, surgeons, and wound evaluation teams were blinded. Serial wound evaluations were performed. Data were analyzed using logistic regression models, Fisher exact test, and t test.


RESULTS
In all, 179 women were randomized, and 160 subjects were included in the analysis. There were 12/83 (14.5%) SSIs in the control group versus 10/77 (13.0%) in the investigational group (p = 0.82). Caucasian race, increased body mass index, and longer operative time were identified as significant risk factors for infection (p = 0.026, odds ratio 0.283; p = 0.05, odds ratio = 1.058; p = 0.037, odds ratio = 1.038, respectively).


CONCLUSIONS
Perioperative oxygenation with 80% Fio2 is not effective in reducing SSI following cesarean delivery.
Departments of Obstetrics and Gynecology, Wright State University and Miami Valley Hospital, Dayton, Ohio.
Ned L
NL
Williams
Melanie M
MM
Glover
Catrina
C
Crisp
Angus L
AL
Acton
David S
DS
Mckenna
D000328:Adult; D015992:Body Mass Index; D002585:Cesarean Section / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D061646:Operative Time; D010100:Oxygen / Q000008:administration & dosage*; D010102:Oxygen Inhalation Therapy; D011182:Postoperative Care; D011247:Pregnancy; D013530:Surgical Wound Infection / Q000209:etiology* / Q000517:prevention & control*; D044465:White People; D055815:Young Adult
D010100:Oxygen