Synchrony analysis of spontaneous MEG activity in Alzheimer's disease patients.
The aim of this study was to analyze the magnetoencephalography (MEG) background activity in Alzheimer's disease (AD) patients using cross-approximate entropy (Cross-ApEn). Cross-ApEn is a nonlinear measure of asynchrony between time series. Five minutes of recording were acquired with a 148-channel whole-head magnetometer in 12 AD patients and 12 age-matched control subjects. We found significantly higher synchrony between MEG signals from AD patients compared with control subjects. Additionally, we evaluated the ability of Cross-ApEn to discriminate these two groups using receiver operating characteristic (ROC) curves with a leave-one-out cross-validation procedure. We obtained an accuracy of 70.83% (66.67% sensitivity, 75% specificity) and a value of area under the ROC curve of 0.83. These results provide evidence of disconnection problems in AD. Our findings show the usefulness of Cross-ApEn to detect the brain dysfunction in AD.
Department of Signal Theory and Communications, E.T.S. Ingenieros de Telecomunicación, University of Valladolid, Campus Miguel Delibes, 47011 – Valladolid, Spain. cargom@tel.uva.es
Carlos
C
Gómez
Mario
M
Martínez-Zarzuela
Jesús
J
Poza
Francisco J
FJ
Díaz-Pernas
Alberto
A
Fernández
Roberto
R
Hornero
D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve