Microwave-assisted improved synthesis of pyrrolo[2,3,4-kl]acridine and dihydropyrrolo[2,3,4-kl]acridine derivatives catalyzed by silica sulfuric acid.
An improved synthesis of multifunctionalized pyrrolo[2,3,4-kl]acridine derivatives with different substituted patterns using silica sulfuric acid (SSA) as a heterogeneous catalyst under microwave irradiation conditions was developed. The reaction could be conducted by using readily available and inexpensive substrates within short periods of 12-15 min. under microwave irradiation. Compared with the conventional methods, the remarkable advantages of this method are milder reaction conditions, operational simplicity, higher yields, short reaction times, and an environmentally friendly procedure.
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Chengpao
C
Cao
Changliang
C
Xu
Wei
W
Lin
Xuemei
X
Li
Minghua
M
Hu
Juxian
J
Wang
Zhibin
Z
Huang
Daqing
D
Shi
Yucheng
Y
Wang
D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D008872:Microwaves; D008956:Models, Chemical; D008968:Molecular Conformation; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013464:Sulfuric Acids / Q000737:chemistry*
D000166:Acridines; D011758:Pyrroles; D013464:Sulfuric Acids; C582134:dihydropyrrolo(2,3,4-kl)acridine; C582133:pyrrolo(2,3,4-kl)acridine; D012822:Silicon Dioxide; C033158:sulfuric acid