[Current cerebrospinal fluid diagnostics for pathogen-related diseases].
Cerebrospinal fluid (CSF) analysis is of utmost importance to establish an early diagnosis of central nervous system (CNS) infections and to start appropriate therapy. The CSF white cell count, lactate concentration and total protein levels are usually available very quickly even from non-specialized laboratories and the combination of these parameters often provides sufficient information for decision-making in emergency cases. It is, however, not always possible to identify the underlying infective agent despite further CSF analyses, such as bacterial and fungal staining, evaluation of the blood-CSF barrier function, intrathecal immunoglobulin synthesis and oligoclonal IgG bands. Therefore, close communication between the laboratory and the clinician is an important prerequisite to specify additional pathogen-related diagnostic measures for successful confirmation of the diagnosis.
Abteilung für Neurologie, Universitätsklinikum Ulm, Uniklinik im RKU, Oberer Eselsberg 45, 890875, Ulm, Deutschland.
S D
SD
Süssmuth
J
J
Brettschneider
A
A
Spreer
M
M
Wick
S
S
Jesse
J
J
Lewerenz
M
M
Otto
H
H
Tumani
D000906:Antibodies / Q000134:cerebrospinal fluid; D002494:Central Nervous System Infections / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D016543:Central Nervous System Neoplasms / Q000134:cerebrospinal fluid / Q000175:diagnosis; D002555:Cerebrospinal Fluid / Q000166:cytology; D002556:Cerebrospinal Fluid Proteins / Q000134:cerebrospinal fluid; D003299:Cooperative Behavior; D003937:Diagnosis, Differential; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000175:diagnosis; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D033183:Interdisciplinary Communication; D019344:Lactic Acid / Q000134:cerebrospinal fluid; D007958:Leukocyte Count; D020852:Lyme Neuroborreliosis / Q000134:cerebrospinal fluid / Q000175:diagnosis; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000175:diagnosis; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D013129:Spinal Puncture; D020306:Tuberculosis, Central Nervous System / Q000134:cerebrospinal fluid / Q000175:diagnosis
D000906:Antibodies; D002556:Cerebrospinal Fluid Proteins; D007136:Immunoglobulins; D019344:Lactic Acid