[Association of variants in chromosome 9p21.3 and chronic periodontitis in the Han Chinese population].
OBJECTIVE
To investigate the association of the single nucleotide polymorphism (SNP) in chromosome 9p21.3 and chronic periodontitis in the Han Chinese population.


METHODS
rs2891168,rs1333048 and rs1333042 genotypes of randomly grouped 172 healthy control subjects and 221 patients with chronic periodontitis(CP) were genotyped by TaqMan probe real-time fluorescent quantitative PCR. Statistical analysis of Chi-square test was performed using SPSS16.0 software package.


RESULTS
Rs2891168 was closely associated with chronic periodontitis(P=0.003), and the frequency of G allele was higher in the patients compared with the control(48.36% vs 40.00%, OR=1.209, 95% CI: 1.001-1.461, P=0.045). Rs1333048 and rs1333042 were not associated with chronic periodontitis.


CONCLUSIONS
There is SNP correlated with chronic periodontitis in chromosome 9p21.3, which indicates that the 9p21.3 locus may be the susceptible region. However, the mechanism remains unclear.
Department of Periodontitis, Shanghai Stomatological Disease Center, Shanghai 200001, China. chendong19690124@126.com
Dong
D
Chen
Ning
N
Wei
Xiao-ni
XN
Bao
Li-ming
LM
Wang
Chun-fei
CF
Zhou
Yu-ling
YL
Zhang
Jie
J
Zhang
D000483:Alleles; D016022:Case-Control Studies; D002681:China; D002899:Chromosomes, Human, Pair 9; D055113:Chronic Periodontitis; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide