Mathematical model of growth factor driven haptotaxis and proliferation in a tissue engineering scaffold.
Motivated by experimental work (Miller et al. in Biomaterials 27(10):2213-2221, 2006, 32(11):2775-2785, 2011) we investigate the effect of growth factor driven haptotaxis and proliferation in a perfusion tissue engineering bioreactor, in which nutrient-rich culture medium is perfused through a 2D porous scaffold impregnated with growth factor and seeded with cells. We model these processes on the timescale of cell proliferation, which typically is of the order of days. While a quantitative representation of these phenomena requires more experimental data than is yet available, qualitative agreement with preliminary experimental studies (Miller et al. in Biomaterials 27(10):2213-2221, 2006) is obtained, and appears promising. The ultimate goal of such modeling is to ascertain initial conditions (growth factor distribution, initial cell seeding, etc.) that will lead to a final desired outcome.
Department of Mathematical Sciences, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA.
J V
JV
Pohlmeyer
S L
SL
Waters
L J
LJ
Cummings
D019149:Bioreactors; D018929:Cell Culture Techniques / Q000379:methods*; D048708:Cell Growth Processes / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D008954:Models, Biological; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
D036341:Intercellular Signaling Peptides and Proteins