Impact of interleukin 1 gene polymorphism and smoking on long-term stability following gingival recession treatment.
Risk factors such as smoking, genetic factors, and tissue biotype play an important role in the etiology, predictability, and long-term stability of gingival recession treatment. This study was designed to evaluate the influence of interleukin 1 (IL-1) polymorphism and smoking on the stability of gingival recession treatment after 1 and 3 years. All patients (n = 55) were treated for type I and II recession defects using a connective tissue graft. Clinical evaluations were performed, which included assessment of vertical recession depth, gingival inflammation, and clinical attachment level. A fingerstick blood sample was collected using specially provided DNA filter paper and mailed for processing in a laboratory using polymerase chain reaction-based methodology. The results indicated that 19 subjects were genotype positive (34.5%). Treatment of the localized recessions was effective and provided a similar amount of coverage in genotype-positive and genotype-negative subjects within smoking and nonsmoking groups after 1 year. In a 3-year period, nonsmoking patients with positive IL-1 genotype lost approximately 20% of the root coverage gained at 1 year and were almost four times more inferior compared with genotype-negative patients. Patients who smoked and had a positive IL-1 genotype lost approximately 35% of the gained root coverage. IL-1 polymorphism and smoking habit did not affect gingival recession treatment at 1 year but had a great impact on long-term stability.
Department of Periodontics, School of Dentistry, University of Belgrade, Belgrade, Republic of Serbia. drsashaj@gmail.com
Sasha
S
Jankovic
Zoran
Z
Aleksic
Bozidar
B
Dimitrijevic
Paulo
P
Camargo
Barry
B
Kenney
Vojislav
V
Lekovic
D000328:Adult; D000483:Alleles; D003238:Connective Tissue / Q000637:transplantation; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D005881:Gingiva / Q000637:transplantation; D005889:Gingival Recession / Q000145:classification / Q000601:surgery*; D005891:Gingivitis / Q000145:classification / Q000628:therapy; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D017622:Periodontal Attachment Loss / Q000145:classification / Q000628:therapy; D010512:Periodontal Index; D011110:Polymorphism, Genetic / Q000235:genetics*; D012008:Recurrence; D012907:Smoking / Q000009:adverse effects*; D014092:Tooth Root / Q000473:pathology / Q000601:surgery; D055815:Young Adult
D007375:Interleukin-1