Assessment of hemodynamic load components affecting optimization of cardiac resynchronization therapy by lumped parameter mode.
Timing of biventricular pacing devices employed in cardiac resynchronization therapy (CRT) is a critical determinant of efficacy of the procedure. Optimization is done by maximizing function in terms of arterial pressure (BP) or cardiac output (CO). However, BP and CO are also determined by the hemodynamic load of the pulmonary and systemic vasculature. This study aims to use a lumped parameter circulatory model to assess the influence of the arterial load on the atrio-ventricular (AV) and inter-ventricular (VV) delay for optimal CRT performance.
Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, Australia. ke.xu1@students.mq.edu.au
Ke
K
Xu
Mark
M
Butlin
Alberto P
AP
Avolio
D062186:Arterial Pressure; D001703:Biophysics; D001794:Blood Pressure; D002302:Cardiac Output; D058406:Cardiac Resynchronization Therapy / Q000379:methods*; D003198:Computer Simulation; D004452:Echocardiography; D004548:Elasticity; D017097:Electric Impedance; D006352:Heart Ventricles / Q000473:pathology; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D013997:Time Factors