[Coexistence of multiple gastrointestinal stromal tumors and signet ring cell carcinoma of stomach in a patient with neurofibromatosis type-1: case report].
Gastrointestinal stromal tumors are mesenchymal neoplasias which are derived     from Cajal's interstitial cells. The most common site of involvement is the     stomach. It may be multiple in patients with Neurofibromatosis Type-1, while the     small intestine is the most common location. In this case report, we aimed to     present a Neurofibromatosis Type-1 patient, showing coexistence of multiple     gastrointestinal stromal tumors in the stomach and small intestine with a signet     ring cell carcinoma in the stomach. A 74-year-old female patient with poor     appetite, vomiting and stomach ache was admitted to the hospital. After     detection of a tumoral lesion with an ulcerated surface in stomach during the     upper gastrointestinal tract endoscopic examination, the patient underwent     surgery. During the operation, multiple nodular lesions were observed in the     serosal surfaces of the small intestine and stomach. Gastrectomy and partial     small intestine resection specimens were evaluated and the patient was diagnosed     as signet ring cell carcinoma in the stomach, and multiple gastrointestinal     stromal tumors in the serosal surfaces of both the stomach and small intestine.     Resection specimens of patients with GIST need to be evaluated carefully on     macroscopic examination, considering the possible presence of a coexistent     tumoral lesion.
Süleyman Demirel Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Isparta, Türkiye.
Nermin
N
Karahan
Şirin
Ş
Başpinar
Kemal Kürşat
KK
Bozkurt
Tuba
T
Devrım
Fatma Nilgün
FN
Kapucuoğlu
D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D015897:Comorbidity; D013505:Digestive System Surgical Procedures; D004724:Endoscopy; D005260:Female; D005743:Gastrectomy; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000175:diagnosis / Q000453:epidemiology*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology