Asperterpenoid A, a new sesterterpenoid as an inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B from the culture of Aspergillus sp. 16-5c.
Asperterpenoid A (1), a novel sesterterpenoid with a new carbon skeleton, has been isolated from a mangrove endophytic fungus Aspergillus sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Asperterpenoid A (1) exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) with an IC(50) value of 2.2 μM.
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
Xishan
X
Huang
Hongbo
H
Huang
Hanxiang
H
Li
Xuefeng
X
Sun
Huarong
H
Huang
Yongjun
Y
Lu
Yongcheng
Y
Lin
Yuhua
Y
Long
Zhigang
Z
She
D001230:Aspergillus / Q000737:chemistry*; D018360:Crystallography, X-Ray; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000378:metabolism; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D012717:Sesquiterpenes; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D012717:Sesquiterpenes; D054830:Sesterterpenes; C581764:asperterpenoid A; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1