Reactive post-radiotherapy bone formation in the maxilla.
OBJECTIVE
High-dose radiation therapy affects bone metabolism, and therefore post-radiotherapy bone formation is an uncommon finding. This case describes an unusual ossification in the maxillary region identified after head and neck radiotherapy.


RESULTS
A 45-year-old female patient was submitted to maxillary surgical resection and orbital exenteration due to squamous cell carcinoma. Radiotherapy post-surgery was performed because of compromised surgical margins. After 4 months of the conclusion of radiotherapy, the patient presented a bone exposition at surgical site. Surprisingly, the oral examination and computed tomography revealed a new formation of the right palatine vault and bone formation filling the nasal and orbital cavity. The incisional biopsy discarded residual disease or osteoradionecrosis and showed normal tissue.


CONCLUSIONS
To the best of the authors' knowledge, this is the first case of wide bone formation as an early effect of head and neck radiotherapy.
Department of Oral Diagnosis, Oral Semiology and Oral Pathology Sections, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.
Fernanda Viviane
FV
Mariano
Rogério Oliveira
RO
Gondak
Alan Roger
AR
Santos-Silva
Marcelo Brum
MB
Corrêa
Oslei Paes de
OP
Almeida
Márcio Ajudarte
MA
Lopes
D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008444:Maxillary Sinus Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D010012:Osteogenesis / Q000528:radiation effects*; D014057:Tomography, X-Ray Computed