Carboxymethyldextran/magnetite hybrid microspheres designed for hyperthermia.
Recently, organic-inorganic hybrids composed of derivatives of dextran, a polysaccharide, and magnetite nanoparticles have attracted much attention as novel thermoseeds. If they can be fabricated into microspheres of size 20-30 μm, they are expected to show not only hyperthermia effects but also embolization effects in human liver and kidney cancers. In this study, we examined the fabrication of carboxymethyldextran/magnetite microspheres using a water/oil emulsion as the reaction medium. Improvement of the chemical stability of the microcapsules by coating with silica using a sol-gel process was also investigated. The obtained hollow microspheres contained particles of size 20-30 μm. Silica coating using an appropriate catalyst for hydrolysis and polycondensation of alkoxysilanes was found to be effective for preventing dissolution and collapse in simulated body environments.
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu 808-0196, Japan. tmiya@life.kyutech.ac.jp
Toshiki
T
Miyazaki
Shota
S
Anan
Eiichi
E
Ishida
Masakazu
M
Kawashita
D002214:Capsules; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D003911:Dextrans / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D004339:Drug Compounding; D052203:Ferrosoferric Oxide / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods; D008422:Materials Testing; D008863:Microspheres; D053761:Nanocomposites / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry / Q000493:pharmacokinetics
D002214:Capsules; D020099:Coated Materials, Biocompatible; D003911:Dextrans; D012822:Silicon Dioxide; C014392:carboxymethyl dextran; D052203:Ferrosoferric Oxide