Association between GABA(A) receptor subunit gene cluster and zolpidem-induced complex sleep behaviors in Han Chinese.
OBJECTIVE
To investigate and elucidate the role of GABA(A) receptor subunits, specifically the 2 genetic markers at the GABA(A) α1 and GABA(A) α6 receptors, in zolpidem-induced complex sleep behaviors (CSBs).


METHODS
Genetic association study.


METHODS
Kaohsiung Medical University-affiliated hospitals, Kaohsiung, Taiwan.


METHODS
30 zolpidem-induced CSB subjects and 37 controls.


METHODS
N/A.


RESULTS
The χ(2) test demonstrated an association between the A15G variant at the GABA(A) α1 receptor subunit gene and zolpidem-induced CSBs (P = 0.007). The adjusted odds ratio of the GABA(A) α1 receptor subunit genotype for the risk of zolpidem-induced CSBs was approximately 10 (OR = 9.99, 95% CI = 1.82, 74.87; P = 0.013).


CONCLUSIONS
The finding reveals that the A15G variant at the GABA(A) α1 receptor subunit gene confers a high risk of zolpidem-induced CSBs and may be considered in clinical services.
Department of Psychiatry, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jui-Hsiu
JH
Tsai
Pinchen
P
Yang
Hung-Hsun
HH
Lin
Kuang-Hung
KH
Cheng
Yi-Hsin
YH
Yang
Ming-Tsang
MT
Wu
Cheng-Chung
CC
Chen
D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D005810:Multigene Family / Q000187:drug effects / Q000235:genetics; D017354:Point Mutation / Q000235:genetics; D011725:Pyridines / Q000009:adverse effects*; D011963:Receptors, GABA-A / Q000235:genetics*; D012890:Sleep / Q000187:drug effects* / Q000235:genetics; D000077334:Zolpidem
C546240:GABRA1 protein, human; D005819:Genetic Markers; D006993:Hypnotics and Sedatives; D011725:Pyridines; D011963:Receptors, GABA-A; D000077334:Zolpidem