Effect of erythropoietin on bone marrow uptake of 18F-fluorocholine in prostate cancer: comparison with 18F-fluoride uptake.
The effect of erythropoietin stimulation on bone marrow uptake of FDG has been well documented. Similar metabolic activation of bone marrow with (18)F-fluorocholine (FCH) has not been previously reported. FCH PET/CT was performed in a patient with biochemical recurrent prostate cancer who was receiving erythropoietin for hemochromatosis. Diffuse skeletal uptake of FCH was seen. (18)F-Fluoride PET/CT performed the following day demonstrates multiple abnormal focal bone metastases. Generalized skeletal uptake of FCH results in poor contrast between the metastases compared to noninvolved bone. The metabolic activation of bone marrow by erythropoietin could result in false-negative FCH results for detecting bone metastases.
Department of Nuclear Medicine, Hôpital Tenon AP-HP, Université Pierre et Marie Curie, Paris, France.
Sona
S
Balogova
Virginie
V
Huchet
Christoph
C
Egrot
Laure
L
Michaud
F
F
Paycha
Khaldoun
K
Kerrou
Francoise
F
Montravers
Olivier
O
Cussenot
Jean Noel
JN
Talbot
D000368:Aged; D001692:Biological Transport / Q000187:drug effects; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism*; D002794:Choline / Q000031:analogs & derivatives* / Q000378:metabolism; D004921:Erythropoietin / Q000494:pharmacology*; D005459:Fluorides / Q000378:metabolism*; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
D005462:Fluorine Radioisotopes; D004921:Erythropoietin; C514960:fluorocholine; D002794:Choline; D005459:Fluorides