MicroRNA: novel modulators of the cholinergic anti-inflammatory pathway.
MicroRNAs (miRNAs) have emerged as key gene regulators controlling the expression of many target mRNAs. The nervous system harbors highest number of miRNAs expressed in a spatially and temporally controlled manner. Neural miRNAs have been accredited with diverse roles like regulation of neural differentiation, synaptogenesis, inflammation, memory and cognition. Their aberrant expression and/or function has been linked to various neurodegenerative, neuroinflammatory and stress related disorders. Recent evidence indicates that miRNAs are essential to the fine tuning of the immune responses. Besides controlling the maturation, proliferation and differentiation of myeloid and lymphoid lineages they participate directly by modulating the signaling pathways through the Toll-like receptors and thus the cytokine response. The miRNAs commuting between the nervous and immune systems and affecting the neuro-immune dialogue are emerging.
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P., India. medha.priyadarshini@gmail.com
Medha
M
Priyadarshini
N A
NA
Arivarasu
Aaliya
A
Shah
Shams
S
Tabrez
Shubha
S
Priyamvada
Mohd
M
Aatif
D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D051193:Toll-Like Receptors / Q000378:metabolism; D014630:Vagus Nerve / Q000276:immunology / Q000378:metabolism
C547077:MIRN132 microRNA, human; D035683:MicroRNAs; D011978:Receptors, Nicotinic; D051193:Toll-Like Receptors; D000110:Acetylcholinesterase; D000109:Acetylcholine