[Review in geriatric medicine 2012].
2012 brought additional evidence regarding the benefits of exercise in older persons in showing morbidity compression in those most active. Several studies invite to revise therapeutic targets in older diabetics, especially those with cognitive impairment or dementia where a value of 8 to 9% for HbAlc might be a good compromise. On the dementia side, a study suggests that biological and structural abnormalities associated with Alzheimer's disease might occur as early as 25 years before its first clinical manifestations. On the therapeutic side, ginkgo and the double therapy with memantine and donepezil did not make it in RCTs, and two studies about treatments for behavioral symptoms of dementia showed that interruption could be deleterious.
Service de gériatrie et réadaptation gériatrique, Département de médecine, CUTR Sylvana, CHUV, 1066 Epalinges.
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K
Major
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L
Saiah
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E
Rubli
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Rochat
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Monod
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Büla
D000368:Aged; D003704:Dementia / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D005853:Geriatrics / Q000379:methods / Q000639:trends*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D009043:Motor Activity / Q000502:physiology; D013997:Time Factors
D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human