Basal ganglia hyperintensity on T1-weighted imaging of a patient with central nervous system metastasis producing carcinoembryonic antigens.
We herein report unusual basal ganglia hyperintense lesions on noncontrast T1-weighted magnetic resonance imaging in a patient with central nervous system metastasis from lung adenocarcinoma that was treated with gefitinib. T2*-weighted magnetic resonance imaging showed no hypointense lesions, thereby excluding the possibility of calcification or haemorrhage. A stereotactic brain biopsy of the left basal ganglia lesions revealed atypical cells, some of which formed a glandular lumen with a micropapillary pattern. These cells were immunopositive for markers of lung adenocarcinoma, thereby confirming the diagnosis of metastasis. We speculate that proteins, including carcinoembryonic antigens from the adenocarcinoma cells in the basal ganglia, may have contributed to the hyperintensity observed on noncontrast T1-weighted magnetic resonance imaging.
Department of Clinical Neuroscience, The University of Tokushima Graduate School, Japan. kof@clin.med.tokushima-u.ac.jp
Koji
K
Fujita
Waka
W
Sakai
Masafumi
M
Harada
Mika
M
Sakaki
Hideo
H
Mure
Shinji
S
Nagahiro
Yuishin
Y
Izumi
Ryuji
R
Kaji
D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology / Q000556:secondary; D000077192:Adenocarcinoma of Lung; D001479:Basal Ganglia / Q000276:immunology / Q000473:pathology*; D001932:Brain Neoplasms / Q000276:immunology / Q000473:pathology* / Q000556:secondary*; D002272:Carcinoembryonic Antigen / Q000096:biosynthesis; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology / Q000556:secondary; D008279:Magnetic Resonance Imaging; D008875:Middle Aged
D002272:Carcinoembryonic Antigen