[Research on the gene structure of duck hepatitis B virus and its encoding proteins].
Duck hepatitis B virus (DHBV) belongs to the Avihepadnavirus genus of the Hepadnaviridae, and it not only has the same replication pattern, but also has the similar genomic and antigenic structures to Hepatitis B virus (HBV). The genome of DHBV is a partially double-stranded closed circular DNA. The genome consists of three distinct open reading frames (ORFs): ORF-PreS/S, ORF-PreC/C and ORF-P, which all locate on the negative DNA strand and encode four separate proteins. The ORF-PreS/S encodes envelope proteins L and S, and the ORF-PreC/C and ORF-P encode capsid proteins C and polymerase proteins P, respectively. The characteristics of genome structure,viral proteins features and functions were described in this review in order to provide useful information for the further study of DHBV and the duck model infected by DHBV.
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. liuqiangdyy@163.com
Qiang
Q
Liu
Ren-Yong
RY
Jia
D000818:Animals; D004372:Ducks; D018347:Hepadnaviridae Infections / Q000662:veterinary* / Q000821:virology; D015611:Hepatitis B Virus, Duck / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D006524:Hepatitis, Viral, Animal / Q000821:virology*; D016366:Open Reading Frames; D017434:Protein Structure, Tertiary; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics*
D014764:Viral Proteins