Does the APC/C Mark MIWI and piRNAs for a final farewell?
Recently in Developmental Cell, Zhao et al. (2013) reported a mechanism for the directed turnover of the mouse Piwi protein MIWI during sperm maturation. This study implicates the anaphase-promoting complex as a mediator of MIWI ubiquitination and expands the avenues for regulating small RNA processes.
Department of Biology and Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, MA 02454, USA.
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Nelson C
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