Prognostic usefulness of eosinopenia in the pediatric intensive care unit.
Eosinopenia, a biomarker for infection, has recently been shown to be a predictor of adult mortality in the intensive care unit (ICU). Our study assessed the usefulness of eosinopenia as a mortality and an infection biomarker in the pediatric ICU (PICU). We compared the PICU mortality scores, eosinophil count and percentage at ICU admission between children who survived and those who did not survive and between children with infection and those without infection. A total of 150 patients were evaluated. The initial eosinophil count and percentage were significantly lower in the group that did not survive when compared to those that did survive (P < 0.001; P < 0.001). However, there was no significant difference in the eosinophil count and percentage seen in patients with and without infection. Eosinopenia, defined as an eosinophil count < 15 cells/µL and an eosinophil percentage < 0.25%, (hazard ratio [HR]: 2.96; P = 0.008) along with a Pediatric Index of Mortality (PIM) 2 (HR: 1.03; P = 0.004) were both determined to be independent predictors of mortality in the PICU. The presence of eosinopenia at the ICU admission can be a useful biomarker for mortality in children, but is not useful as a biomarker for infection.
Department of Pediatrics and Institute of Allergy, Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Yoon Hee
YH
Kim
Hyun Bin
HB
Park
Min Jung
MJ
Kim
Hwan Soo
HS
Kim
Hee Seon
HS
Lee
Yoon Ki
YK
Han
Kyung Won
KW
Kim
Myung Hyun
MH
Sohn
Kyu-Earn
KE
Kim
D000380:Agranulocytosis / Q000175:diagnosis*; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004804:Eosinophils / Q000166:cytology*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007239:Infections / Q000401:mortality / Q000473:pathology; D015278:Intensive Care Units, Pediatric; D007958:Leukocyte Count; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D015996:Survival Rate
D015415:Biomarkers
Biomarkers; Child; Eosinophils; Infection; Intensive Care Units; Prognosis