Potential MiRNAs recognition site identification in 3' UTR regions by DSP methods.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate fundamental cellular processes in diverse organisms and that have an important function in gene expression regulation. miRNAs seem capable to concurrently modulate hundreds of target genes. Their abnormal expression is emerging as important element in many pathological conditions. The identification of microRNA binding sites on those proteins that can be disease biomarker is fundamental to design synthetic artificial oligomers. In this paper we suggest a method, based on signal processing, to filter out potential miRNA recognition sites in the 3' UTR region of mRNAs.
Department of Communication, Computer and System Sciences, Nanobiotechnology and Medical Informatics Laboratory University of Genoa, Via all’Opera Pia, 13, 16145 Genoa, Italy.
Norbert
N
Maggi
Patrizio
P
Arrigo
Carmelina
C
Ruggiero
D020413:3' Untranslated Regions; D005786:Gene Expression Regulation; D035683:MicroRNAs / Q000235:genetics*
D020413:3' Untranslated Regions; D035683:MicroRNAs