Switches, switches, every where, in any drop we drink.
In this issue, Broussard et al. (2013) report genetic switches that regulate cell fate selection; a recombinase attachment site is embedded within a repressor coding sequence, such that integration truncates a proteolysis domain, stabilizing the repressor and setting the switch.
Department of Bioengineering, Y2E2-269B, 473 Via Ortega, Stanford University, Stanford, CA 94305-4201, USA.
Jérôme
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Bonnet
Drew
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Endy