Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study.
Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect) ,and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of 20.26 mmol/l per A-allele/protein unit (95% CI 20.38, 20.14, P=0.000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg C, Denmark.
Lena K
LK
Brahe
Lars
L
Ängquist
Lesli H
LH
Larsen
Karani S
KS
Vimaleswaran
Jörg
J
Hager
Nathalie
N
Viguerie
Ruth J F
RJ
Loos
Teodora
T
Handjieva-Darlenska
Susan A
SA
Jebb
Petr
P
Hlavaty
Thomas M
TM
Larsen
J Alfredo
JA
Martinez
Angeliki
A
Papadaki
Andreas F H
AF
Pfeiffer
Marleen A
MA
van Baak
Thorkild I A
TI
Sørensen
Claus
C
Holst
Dominique
D
Langin
Arne
A
Astrup
Wim H M
WH
Saris
D051702:Activating Transcription Factor 6 / Q000235:genetics / Q000378:metabolism; D000328:Adult; D008076:Cholesterol, HDL / Q000235:genetics / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism*; D050556:Fatty Acid-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D038321:Glycemic Index / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010711:Phosphatidate Phosphatase / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
C497111:ATF6 protein, human; D051702:Activating Transcription Factor 6; D008076:Cholesterol, HDL; D004044:Dietary Proteins; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; C502575:LPIN2 protein, human; D008055:Lipids; D009687:Nuclear Proteins; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors; C548261:LPL protein, human; D008071:Lipoprotein Lipase; C485999:LPIN1 protein, human; D010711:Phosphatidate Phosphatase