Association of inflammation with atrial fibrillation in hyperthyroidism.
OBJECTIVE
The aim of this study was to evaluate the relationship between inflammation and development of atrial fibrillation (AF) in patients with hyperthyroidism.


METHODS
A total of 65 patients with newly diagnosed hyperthyroidism, 35 of whom were in sinus rhythm and 30 of whom in AF. Thirty five age- and gender-matched patients in a control group were included in the study. Factors associated with the development of AF were evaluated by multivariate regression analysis.


RESULTS
FACTORS ASSOCIATED WITH AF IN MULTIVARIATE ANALYSIS INCLUDED HIGH SENSITIVITY C REACTIVE PROTEIN (HSCRP) [ODDS RATIO (OR): 11.19; 95% confidence interval (95% CI): 1.80-69.53; P = 0.003], free T4 (OR: 8.76; 95% CI: 2.09-36.7; P = 0.003), and left atrial diameter (OR: 1.25; 95% CI: 1.06-1.47; P = 0.008).


CONCLUSIONS
The results of the present study suggest that HsCRP, an indicator of inflammation, free T4 and left atrial diameter are associated with the development AF in patients with hyperthyroidism.
Department of Cardiology, Suleyman Demirel University, Kurtulus Mah 122. cad. Hatice Halici apt. no: 126, 32040 Isparta, Turkey.
Mehmet
M
Ozaydin
Ali
A
Kutlucan
Yasin
Y
Turker
Banu
B
Koroglu
Akif
A
Arslan
Bayram A
BA
Uysal
Dogan
D
Erdogan
Ercan
E
Varol
Abdullah
A
Dogan
Atrial fibrillation; Hyperthyroidism; Inflammation