Hypochlorous acid turn-on fluorescent probe based on oxidation of diphenyl selenide.
A BODIPY-based fluorescent probe, HCSe, has been successfully developed for the rapid detection of hypochlorous acid based on the specific HOCl-promoted oxidation of diphenyl selenide in response to the amount of HOCl. Confocal fluorescence microscopy imaging using RAW264.7 cells showed that the new probe HCSe could be used as an effective fluorescent probe for detecting HOCl in living cells.
Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan 300, ROC.
Shi-Rong
SR
Liu
Shu-Pao
SP
Wu
D000818:Animals; D001713:Biphenyl Compounds / Q000737:chemistry*; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006997:Hypochlorous Acid / Q000032:analysis* / Q000737:chemistry; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction
D001713:Biphenyl Compounds; D001896:Boron Compounds; D005456:Fluorescent Dyes; D006997:Hypochlorous Acid; D016566:Organoselenium Compounds; C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; C010574:biphenyl