'One-pot' synthesis of dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a silver(I)-catalyzed cascade approach.
An efficient approach for the synthesis of biologically interesting fused tetracyclic isoquinolines in high yields and with a broad substrate scope has been developed. The strategy features an AgNO(3) catalyzed 'one-pot' cascade process involving formation of two new C-N bonds and one new C-O bond.
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China. jianli@ecust.edu.cn
Baifeng
B
Jiang
Yu
Y
Zhou
Qingya
Q
Kong
Hualiang
H
Jiang
Hong
H
Liu
Jian
J
Li
D002384:Catalysis; D018360:Crystallography, X-Ray; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D012835:Silver Nitrate / Q000737:chemistry*
D007546:Isoquinolines; D010078:Oxazines; D012835:Silver Nitrate