Kinetic trapping of the host-guest association intermediate and its transformation into a thermodynamic inclusion complex.
The molecular recognition and self-assembly between host cucurbit[6]uril and guest adrenaline led to kinetic trapping and crystallization of the intermediate exclusion complex, which was characterized by X-ray diffraction. The crystalline kinetic complex undergoes slow spontaneous dissolution and subsequently recrystallizes as a thermodynamic inclusion complex.
Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warszawa, Poland. odanylyuk@ichf.edu.pl
Oksana
O
Danylyuk
Vladimir P
VP
Fedin
Volodymyr
V
Sashuk
D001952:Bridged-Ring Compounds / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007093:Imidazoles / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D015394:Molecular Structure; D013816:Thermodynamics; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D001952:Bridged-Ring Compounds; D007093:Imidazoles; C454805:cucurbit(6)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils