Obsessive compulsive personality disorder and Parkinson's disease.
OBJECTIVE
To evaluate the frequency of personality disorders in Parkinson's disease (PD) patients and in a group of healthy controls.


METHODS
Patients affected by PD diagnosed according to the United Kingdom Parkinson's disease Society Brain Bank diagnostic criteria and a group of healthy controls were enrolled in the study. PD patients with cognitive impairment were excluded from the study. Structured Clinical Interview for Personality Disorders-II (SCID-II) has been performed to evaluate the presence of personality disorders. Presence of personality disorders, diagnosed according to the DSM-IV, was confirmed by a psychiatric interview. Clinical and pharmacological data were also recorded using a standardized questionnaire.


RESULTS
100 PD patients (57 men; mean age 59.0 ± 10.2 years) and 100 healthy subjects (52 men; mean age 58.1 ± 11.4 years) were enrolled in the study. The most common personality disorder was the obsessive-compulsive personality disorder diagnosed in 40 PD patients and in 10 controls subjects (p-value<0.0001) followed by the depressive personality disorder recorded in 14 PD patients and 4 control subjects (p-value 0.02). Obsessive-compulsive personality disorder was also found in 8 out of 16 de novo PD patients with a short disease duration.


CONCLUSIONS
PD patients presented a high frequency of obsessive-compulsive personality disorder that does not seem to be related with both disease duration and dopaminergic therapy.
Dipartimento G.F. Ingrassia Sezione di Neuroscienze, Università di Catania, Catania, Italy.
Alessandra
A
Nicoletti
Antonina
A
Luca
Loredana
L
Raciti
Donatella
D
Contrafatto
Elisa
E
Bruno
Valeria
V
Dibilio
Giorgia
G
Sciacca
Giovanni
G
Mostile
Antonio
A
Petralia
Mario
M
Zappia
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000150:complications*; D010300:Parkinson Disease / Q000150:complications*