Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines.
Although current therapies have improved leukemia survival rates, adverse drug effects and relapse are frequent. Encapsulation of edelfosine (ET) in lipid nanoparticles (LNs) improves its oral bioavailability and decreases its toxicity. Here we evaluated the efficacy of ET-LN in myeloid leukemia cell lines. Drug-loaded LN were as effective as free ET in sensitive leukemia cell lines. Moreover, the encapsulated drug overcame the resistance of the K562 cell line to the drug. LN containing ET might be used as a promising drug delivery system in leukemia due to their capacity to overcome the in vivo pitfalls of the free drug and their efficacy in vitro in leukemia cell lines.
Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, University of Navarra, E-31080 Pamplona, Spain.
Beatriz
B
Lasa-Saracíbar
Ander
A
Estella-Hermoso de Mendoza
Faustino
F
Mollinedo
María D
MD
Odero
María J
MJ
Blanco-Príeto
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D002627:Chemistry, Physical; D016503:Drug Delivery Systems / Q000379:methods; D019008:Drug Resistance, Neoplasm; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008055:Lipids / Q000008:administration & dosage* / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010742:Phospholipid Ethers / Q000008:administration & dosage* / Q000737:chemistry
D000970:Antineoplastic Agents; D008055:Lipids; D010742:Phospholipid Ethers; C026659:edelfosine; D020169:Caspases