Modeling the influences of nanoparticles on neural field oscillations in thalamocortical networks.
The purpose of this study is twofold. First, we present a simplified multiscale modeling approach integrating activity on the scale of ionic channels into the spatiotemporal scale of neural field potentials: Resting upon a Hodgkin-Huxley based single cell model we introduced a neuronal feedback circuit based on the Llinás-model of thalamocortical activity and binding, where all cell specific intrinsic properties were adopted from patch-clamp measurements. In this paper, we expand this existing model by integrating the output to the spatiotemporal scale of field potentials. Those are supposed to originate from the parallel activity of a variety of synchronized thalamocortical columns at the quasi-microscopic level, where the involved neurons are gathered together in units. Second and more important, we study the possible effects of nanoparticles (NPs) that are supposed to interact with thalamic cells of our network model. In two preliminary studies we demonstrated in vitro and in vivo effects of NPs on the ionic channels of single neurons and thereafter on neuronal feedback circuits. By means of our new model we assumed now NPs induced changes on the ionic currents of the involved thalamic neurons. Here we found extensive diversified pattern formations of neural field potentials when comparing to the modeled activity without neuromodulating NPs addition. This model provides predictions about the influences of NPs on spatiotemporal neural field oscillations in thalamocortical networks. These predictions can be validated by high spatiotemporal resolution electrophysiological measurements like voltage sensitive dyes and multiarray recordings.
Systems Neuroscience and Neurotechnology Unit, Neurocenter, Saarland University Hospital, Homburg/Saarbruecken, Germany. busse@snn-unit.de
Michael
M
Busse
Annette
A
Kraegeloh
Eduard
E
Arzt
Daniel J
DJ
Strauss
D003198:Computer Simulation; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008959:Models, Neurological; D053758:Nanoparticles / Q000008:administration & dosage*; D009415:Nerve Net / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D013788:Thalamus / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*
D007473:Ion Channels