Rictor encounters RhoGDI2: the second pilot is taking a lead.
Rictor's role in cell migration has been first indicated in the original chemotaxis studies in Dictyostelium and more recent studies reported that rictor is required for migration of cancer cells. How rictor promotes cell migration remains poorly characterized. Based on our proteomics study we have identified a novel functional role of rictor in regulation of cell migration. Here, we discuss our recent finding that rictor by suppressing RhoGDI2 maintains activity of the Rac1/cdc42 GTPases and promotes cell migration. Our finding outlines a critical role of rictor in the regulation of RhoGDI2 activity. This study opens new avenues in the investigation of cancer metastasis by analyzing the rictor dependent post-translational modification of RhoGDI2.
Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Nitin K
NK
Agarwal
Dubek
D
Kazyken
Dos D
dos D
Sarbassov
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D062949:rho Guanine Nucleotide Dissociation Inhibitor beta / Q000378:metabolism*
D002352:Carrier Proteins; D062949:rho Guanine Nucleotide Dissociation Inhibitor beta
Rac1; Rho GTPases; RhoGDI2; cell migration; rictor