Relapsing, remitting hypercortisolism in Cushing's disease due to intratumoral hemorrhages in pituitary microadenoma.
We report two patients with Cushing's disease (CD) from adrenocorticotropic hormone-secreting microadenomas in whom intralesional hemorrhage caused an episodic, remitting and relapsing pattern of hypercortisolism. To our knowledge this is the first report of patients in whom hemorrhage within a microadenoma caused cyclic CD. Both patients were treated successfully with transsphenoidal surgery.
The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Department of Neurosurgery, Neurological Institute, The Cleveland Clinic, Cleveland, OH, USA. Nicholas.Marko@cancer.org.uk
Nicholas F
NF
Marko
Amir H
AH
Hamrahian
Betul
B
Hatipoglu
Robert J
RJ
Weil
D049913:ACTH-Secreting Pituitary Adenoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D000328:Adult; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D008875:Middle Aged; D047748:Pituitary ACTH Hypersecretion / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D016896:Treatment Outcome
D006854:Hydrocortisone