Exercise and hematopoietic stem and progenitor cells: protection, quantity, and function.
The effects of exercise on mature cells of the hematopoietic lineage have been well characterized; however, the effects of exercise on the more primitive cells of the hematopoietic system are unknown. Here, we propose that the benefits of exercise apply to hematopoietic progenitors and that exercise increases hematopoietic stem cell quantity primarily mediated via adaptations in the stem cell niche.
Department of Kinesiology, McMaster University, Hamilton, Canada.
Michael
M
De Lisio
Gianni
G
Parise
D000818:Animals; D015444:Exercise / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D059165:Hormesis; D006801:Humans; D055153:Stem Cell Niche