Possible antistenotic effect of tranilast in a patient with small bowel tuberculosis to prevent intestinal obstruction due to stenosis progression by antituberculous chemotherapy.
Small intestinal tuberculosis is a rare disorder of the small intestine. We report the development of deep small bowel tuberculosis in a rheumatoid arthritis patient who was taking methotrexate. The diagnosis of small bowel tuberculosis was ascertained by typical endoscopic findings and production of interferon gamma in the peripheral blood. The patient was successfully treated with antituberculous chemotherapy combined with an antifibrotic agent, tranilast, to suppress the progression of intestinal stenosis toward symptomatic stricture.
Department of Gastroenterology, Izumiotsu Municipal Hospital, Izumiotsu City, Osaka 595-3027, Japan. endoscope@hosp-ozu-osaka.jp
Nobuhide
N
Oshitani
Shogo
S
Takeda
Hiroko
H
Matsumoto
Hiroaki
H
Minamino
Tsuyoshi
T
Hayakawa
Kazuki
K
Aomatsu
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use; D018450:Disease Progression; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000382:microbiology* / Q000517:prevention & control*; D007421:Intestine, Small; D008875:Middle Aged; D014385:Tuberculosis, Gastrointestinal / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D062367:ortho-Aminobenzoates / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000995:Antitubercular Agents; D062367:ortho-Aminobenzoates; C012293:tranilast