Discovery of hepatitis C virus NS3 helicase inhibitors by a multiplexed, high-throughput helicase activity assay based on graphene oxide.
Department of Chemistry, KAIST, Daejeon, 305-701, Korea.
Hongje
H
Jang
Soo-Ryoon
SR
Ryoo
Young-Kwan
YK
Kim
Soojin
S
Yoon
Henna
H
Kim
Sang Woo
SW
Han
Byong-Seok
BS
Choi
Dong-Eun
DE
Kim
Dal-Hee
DH
Min
D001681:Biological Assay / Q000379:methods*; D002478:Cells, Cultured; D055808:Drug Discovery; D006108:Graphite / Q000737:chemistry*; D016174:Hepacivirus; D006801:Humans; D020128:Inhibitory Concentration 50; D010087:Oxides / Q000737:chemistry; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D006108:Graphite; D010087:Oxides; D011480:Protease Inhibitors; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases