Release kinetics of 5-aminosalicylic acid from halloysite.
This paper investigates desorption of 5-aminosalicilyc acid (5-ASA) adsorbed onto halloysite (HL). Desorption isotherms were fitted according to kinetic laws obtained considering release of 5-ASA from HL as the phase of desorption of the previously adsorbed drug molecules both inside the nanotubes of HL as onto the surface of clay particles and/or in the inter-particle spaces of their aggregates. Desorption isotherms has been also fitted with other equations frequently used in drug release kinetics studies. The best fitting corresponded to the kinetic model proposed; in agreement with the results of adsorption.
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Granada, Spain.
C
C
Aguzzi
C
C
Viseras
P
P
Cerezo
I
I
Salcedo
R
R
Sánchez-Espejo
C
C
Valenzuela
D000538:Aluminum Silicates / Q000737:chemistry / Q000378:metabolism*; D000077215:Clay; D007700:Kinetics; D019804:Mesalamine / Q000737:chemistry / Q000378:metabolism*; D008956:Models, Chemical; D043942:Nanotubes
D000538:Aluminum Silicates; D019804:Mesalamine; D000077215:Clay