Microarray analysis of neonatal brain exposed to cadmium during gestation and lactation.
DNA microarray containing 30,000 genes was used to monitor the transcriptional response of the neonatal brain after cadmium (Cd) exposure. C57BL/6J pregnant mice were exposed to Cd (10 ppm) during gestation and lactation via drinking water. In a comparison between the Cd-exposed neonatal brain and control, three genes including transferrin receptor (Tfrc) were up-regulated and one gene was down-regulated.
Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Akiko
A
Honda
Chiho
C
Watanabe
Minoru
M
Yoshida
Hisamitsu
H
Nagase
Masahiko
M
Satoh
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002104:Cadmium / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects*; D039663:Integrin beta4 / Q000235:genetics; D007774:Lactation; D008431:Maternal-Fetal Exchange; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D011247:Pregnancy; D060888:Real-Time Polymerase Chain Reaction; D011990:Receptors, Transferrin / Q000235:genetics; D051140:Selenoproteins / Q000235:genetics; D039961:Semaphorins
D004785:Environmental Pollutants; D039663:Integrin beta4; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011990:Receptors, Transferrin; C495239:Selenof protein, mouse; D051140:Selenoproteins; C103619:Sema5A protein, mouse; D039961:Semaphorins; C480029:Tfrc protein, mouse; D002104:Cadmium