Beat-to-beat spatial and temporal analysis for QRS-T morphology.
The aim of this study was to investigate beat-to-beat variations of spatial and temporal QRS and T loop morphology for identifying myocardial infarction (MI) patients. We investigated short-term 12-lead ECG recordings of 84 MI patients (22 female, mean age 63 ± 12 years and 62 male, mean age 56 ± 10 years) and 69 healthy control subjects (17 female, mean age 42 ± 18 years and 52 male, mean age 40 ± 13 years). To quantify spatial and temporal variations in QRS complex and T-wave morphology, we defined two descriptor parameters: point-to-point distance variability (DV) and mean loop length (MLL). These parameters were extracted from the reconstructed vector ECG, using singular value decomposition. The results showed that the beat-to-beat spatiotemporal point-to-point distance variability for QRS and T loops (DV(QRS); 0.13 ± 0.04 vs. 0.10 ± 0.04, p < 0.0001 and DV(T); 0.16 ± 0.07 vs. 0.13 ± 0.06, p < 0.05), were significantly higher in MI subjects compared to control subjects. In addition, the mean loop length of QRS and T loops were significantly higher in control subjects than MI (p < 0.001), respectively. In conclusion, the beat-to-beat spatiotemporal DV and MLL may be useful for characterizing conduction and repolarization characteristics in patients with MI.
School of Electrical and Electronic Engineering, University of Adelaide, SA 5005, Australia. muhammad.hasan@adelaide.edu.au
Muhammad A
MA
Hasan
Derek
D
Abbott
Mathias
M
Baumert
D000465:Algorithms; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014672:Vectorcardiography / Q000379:methods*