Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats.
Saturated and trans fatty acids have been associated with the risk to develop cardiovascular diseases. However, health-promoting effects are associated with consumption of anhydrous milk fat (AMF) and ruminant trans fatty acids, such as conjugated linoleic acid (CLA) and vaccenic acid (VA) contained in the lipid fraction of milk and dairy products. The purpose of this study was to evaluate the effect of AMF naturally enriched with CLA and VA in spontaneously hypertensive rats (SHR), using sterculic oil to inhibit the conversion of VA into CLA. The administration of AMF to SHR during 7 weeks exerted beneficial effects on cardiovascular risk biomarkers (reduction of insulin, blood lipids, increase of adiponectin). When sterculic oil was included, some parameters were further ameliorated (reduction of insulin, increase of adiponectin). Sterculic oil alone reduced body weight and adiposity, and improved blood pressure, adiponectin and triglyceride levels.
Unidad de Investigación y Desarrollo en Alimentos, Instituto Tecnológico de Veracruz, Veracruz, Veracruz, Mexico.
M S
MS
Herrera-Meza
M R
MR
Mendoza-López
O
O
García-Barradas
M G
MG
Sanchez-Otero
E R
ER
Silva-Hernández
J O
JO
Angulo
R M
RM
Oliart-Ros
D052242:Adiponectin / Q000097:blood; D050154:Adiposity / Q000187:drug effects; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D003521:Cyclopropanes / Q000494:pharmacology / Q000627:therapeutic use; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology / Q000627:therapeutic use*; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology / Q000627:therapeutic use; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007328:Insulin / Q000097:blood; D019787:Linoleic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D008892:Milk / Q000737:chemistry*; D009829:Oleic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D012418:Ruminants; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss / Q000187:drug effects
D052242:Adiponectin; D015415:Biomarkers; D003521:Cyclopropanes; D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D007328:Insulin; D044243:Linoleic Acids, Conjugated; D008055:Lipids; D009829:Oleic Acids; D014280:Triglycerides; D019787:Linoleic Acid; C050413:11-octadecenoic acid; C003345:sterculic acid