[Structure, antioxidative and anticancer properties of flavonoids].
Flavonoids are compounds occuring in plants, e.g. in fruits and vegetables. Flavonoids have been identified as: flavones, flavanones, flavanols (flavan-3-ols), flavonols, anthocyanidines, isoflavonoids and neoflavonoids. Their antioxidative properties are connected with their ability to scavenge free radicals. Their antioxidant properties are linked to the ability to chelate transitional metal ions, mainly copper and iron and to increase antioxidant capacity by the stimulation of the activity of important antioxidant enzymes: superoxide dismutase, glutathione peroxidase and catalase. Flavonoids are able to inhibit the activities of prooxidant enzymes such as cyclooxygenase, lipooxygenase, xanthine oxidase and expression of inducible nitric oxide synthase. These compounds can also regenerate ascorbyl and tocoferoxyl radicals to corresponding vitamins. Pharmacological properties of flavonoids are manifested in different ways. They display antiviral, anti-allergic, anti-inflammatory and anticancer properties. Flavonoids play also a role as inhibitors of neurodegenerative diseases (Alzheimer and Parkinson's diseases) and ageing. Moreover, protective effects against ionizing and UV radiation have been shown for flavonoids. In this paper the antioxidative properties and antitumour action of flavonoids, such as blockade of cell cycle, activation of apoptosis pathways and inhibition of cancerogenesis by inactivation of some carcinogens are reviewed.
Zakład Badań Struktur Biopolimerów, Katedra Biofizyki Molekularnej, Uniwersytet Łódzki, Lódź. czaplinska.malgorzata@gmail.com
Małgorzata
M
Czaplińska
Jan
J
Czepas
Krzysztof
K
Gwoździński
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D005415:Flavins / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular
D000970:Antineoplastic Agents; D000975:Antioxidants; D005415:Flavins