Types of HLA in the bladder transitional cell carcinoma (TCC).
HLA plays a complementary role in the interaction between tumor and body immunology. The aim of this study was to determine the existence of the association between the HLA system and transitional cell carcinoma (TCC). Using standard micro-lymphocytotoxic method of Terasaki, HLA-A, B, DR and DQ antigen types of 30 patients with TCC of the bladder were compared with the control group (30 healthy people). In the TCC patient group, HLA -DQ6(1) and HLA -DQ7(3) antigens were detected with a significantly higher frequency than in the control group (p=0.018 and p=0.038, respectively), whereas HLA-A10, B4, DR53 and DQ1 antigens were detected with significantly higher frequency in the control group (p less 0.05 in all). It suggests that patients who had the antigens detected were at higher risk of TCC, and the ones who had the antigens displaying protective features as were detected in the control group, were at lesser risk.
1Blood Bank, Tissue Typing Laboratory, 2Urology Department; School of Medicine, Istanbul University, Cerrahpaşa, 3Bursa Morgue Department, Council of Forensic Medicine of Turkey, 3Bursa Morgue Department, Council of Forensic Medicine of Tur- key, Bursa, 4Pediatric Surgery Department, Cerrahpasa  School of Medicine, Istanbul University; Turkey.
Erkan
E
Yılmaz
Ali
A
Uğur Özalp
Arman
A
Cekmen
Bülent
B
Eren
Bülent
B
Onal
Emre
E
Akkuş
Ergun
E
Erdoğan
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002295:Carcinoma, Transitional Cell / Q000097:blood / Q000276:immunology* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D015234:HLA-A Antigens / Q000097:blood*; D015235:HLA-B Antigens / Q000097:blood*; D006683:HLA-DQ Antigens / Q000097:blood*; D006684:HLA-DR Antigens / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000276:immunology* / Q000473:pathology
D014408:Biomarkers, Tumor; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens