Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation.
BACKGROUND
Serum preptin levels among subjects with different bone mineral densities (BMD) were measured and investigated to determine the correlation between BMD and bone-metabolic markers.


METHODS
Approximately 52 elderly male patients with osteoporosis, 50 elderly men with osteopaenia, and 31 age-matched normal bone mass controls participated in the study. The serum preptin levels and bone metabolic markers were measured by enzyme-linked immunosorbent assay. The relationships between preptin levels, BMD, and metabolic parameters were also assessed.


RESULTS
The serum preptin level was the lowest in the osteoporosis group and positively correlated with BMD. All the bone formation markers in the osteoporosis and osteopaenia groups were significantly reduced compared with those in the normal group. Serum preptin level was positively correlated with all the bone formation markers, whereas no correlation was observed with the bone resorption marker TRACP-5b.


CONCLUSIONS
Serum preptin levels are decreased in osteoporosis and osteopaenia patients and positively correlated with BMD. Therefore, preptin is involved in the pathogenesis of osteoporosis, probably through bone formation rather than bone resorption.
Department of Rheumatology, Shanghai East Hospital, Tong Ji University, Shanghai, China.
Ning
N
Li
Yi-Bo
YB
Zheng
Jie
J
Han
Wei
W
Liang
Jia-Yi
JY
Wang
Jie-Ru
JR
Zhou
Yi
Y
Shen
Jie
J
Zhang
D015502:Absorptiometry, Photon; D000135:Acid Phosphatase / Q000097:blood; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D016022:Case-Control Studies; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000503:physiopathology; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007335:Insulin-Like Growth Factor II; D007527:Isoenzymes / Q000097:blood; D016014:Linear Models; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D015999:Multivariate Analysis; D010012:Osteogenesis; D010024:Osteoporosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D010446:Peptide Fragments / Q000097:blood*; D000071681:Tartrate-Resistant Acid Phosphatase
D015415:Biomarkers; D007527:Isoenzymes; D010446:Peptide Fragments; C443100:preptin; D007335:Insulin-Like Growth Factor II; C000605510:ACP5 protein, human; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase