The prevention and genetics of pancreatic cancer: a programmatic approach.
Pancreatic cancer (PC) is typically a fatal disease due to its rapid growth and the lack of early diagnostic -techniques. Because approximately 10% of PCs are attributable to a hereditary susceptibility, identifying and studying patients with a family history of PC or known genetic predisposition to PC can improve the prevention, diagnosis, and treatment of PC. A skilled team of study investigators, physicians, genetic counselors, and data managers must work with patients and families to confidentially store and organize data from PC patients and high-risk patients. This data, collected in conjunction with patients' tissue and blood specimens, will contribute to the understanding of the biology, etiology, and epidemiology of PC, and can ultimately improve screening and management for patients with an underlying hereditary predisposition to PC.
Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Aimee L
AL
Lucas
Michelle M
MM
Chang
Marla D
MD
Lipsyc
Harold
H
Frucht
D018070:Biological Specimen Banks; D016208:Databases, Factual; D055088:Early Detection of Cancer; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D018570:Risk Assessment; D011795:Surveys and Questionnaires