Two cerebrosides isolated from the seeds of Sterculia lychnophora and their neuroprotective effect.
Two cerebrosides named 1-O-b-D-glucopyranosyl-(2S,3R,4E,8Z)-2-[(2-hydroxyoctadecanoyl)amido]-4,8-octadecadiene-1,3-diol (1) and soya-cerebroside I (2) were isolated from the seeds of Sterculia lychnophora for the first time. Their structures were completely characterized by spectroscopic methods including IR, MS and NMR. Compound 1 exhibited moderate neuroprotective effect against SH-SY5Y cell damage induced by hydrogen peroxide.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. wangrufeng@tsinghua.org.cn
Ru-Feng
RF
Wang
Xiu-Wen
XW
Wu
Di
D
Geng
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016877:Oxidants / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry*; D032361:Sterculia / Q000737:chemistry*
D002554:Cerebrosides; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D016877:Oxidants; D006861:Hydrogen Peroxide