Neuroprotective effect of acute interferon-beta 1B treatment after spinal cord injury.
OBJECTIVE
The purpose of this trial was to investigate the effect of a well known     immunomodulator -interferon beta- on traumatized spinal cord in terms of     biochemical and histopathological features.


METHODS
Twenty-four     rats were used in this trial. The rats were divided into 3 groups. In the first     group of rats, spinal cord injury was created by the weight drop method and     interferon beta was administered. In the second group, physiological saline was     administered. Third group was used as control. Rats were sacrificed 24 hours     following trauma. Heat shock protein 70 levels were measured in the spinal cord     samples and the samples were examined histopathologically.


RESULTS
When the     rats in the physiological saline and control groups were compared to rats     treated with interferon beta 1b, those treated with interferon beta 1b revealed     significant increases in the heat shock protein 70 levels in tissues, and     histopathological examination revealed decreases in polymorphonuclear leucocyte     infiltration, haemorrhage, oedema and necrosis.


CONCLUSIONS
Although, the     results of the study indicated that interferon beta might have some healing     effects via increasing the cellular heat shock protein 70 on spinal cord     injuries, more studies are needed.
Ataturk University, Faculty of Medicine, Department of Neurosurgery, Erzurum, Turkey. goksinsengul@gmail.com
Goksin
G
Sengul
Mustafa Kemal
MK
Coban
Murteza
M
Cakir
Suleyman
S
Coskun
Hulya
H
Aksoy
Ahmet
A
Hacimuftuoglu
Fatih
F
Saruhan
Muhammed
M
Calik
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006470:Hemorrhage / Q000188:drug therapy / Q000473:pathology; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D009336:Necrosis / Q000188:drug therapy / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects
D000276:Adjuvants, Immunologic; D018840:HSP70 Heat-Shock Proteins; D018696:Neuroprotective Agents; D000068576:Interferon beta-1b; D016899:Interferon-beta