Long-term mortality and quality of life after septic shock: a follow-up observational study.
OBJECTIVE
In septic shock, short-term outcomes are frequently reported, while long-term outcomes are not. The aim of this study was to evaluate mortality and health-related quality of life (HRQOL) in survivors 6 months after an episode of septic shock.


METHODS
This single-centre observational study was conducted in an intensive care unit in a university hospital. All patients with septic shock were included. Mortality was assessed 6 months after the onset of septic shock, and a comparison between patients who survived and those who died was performed. HRQOL was assessed using the MOS SF-36 questionnaire prior to hospital admission (baseline) and at 6 months in survivors. HRQOL at baseline and at 6 months were compared to the general French population, and HRQOL at baseline was compared to 6-month HRQOL.


RESULTS
Ninety-six patients were included. Six-month mortality was 45%. Survivors were significantly younger, had significantly lower lactate levels and SAPS II scores, required less renal support, received less frequent administration of corticosteroids, and had a longer length of hospital stay. At baseline (n = 39) and 6 months (n = 46), all of the components of the SF-36 questionnaire were significantly lower than those in the general population. Compared to baseline (n = 23), the Physical Component Score (CS) improved significantly at 6 months, the Mental CS did not differ.


CONCLUSIONS
Mortality 6 months after septic shock was high. HRQOL at baseline was impaired when compared to that of the general population. Although improvements were noted at 6 months, HRQOL remained lower than that in the general population.
Département d'Anesthésie-Réanimation 1, Inserm U991, Service de Réanimation Chirurgicale, Hôpital Pontchaillou, Université Rennes 1, Rennes, France. nicolas.nesseler@chu-rennes.fr
Nicolas
N
Nesseler
Anne
A
Defontaine
Yoann
Y
Launey
Jeff
J
Morcet
Yannick
Y
Mallédant
Philippe
P
Seguin
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D005602:France / Q000453:epidemiology; D006305:Health Status Indicators; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D012307:Risk Factors; D012772:Shock, Septic / Q000401:mortality*; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires