Microbial transformation of cycloastragenol.
The microbial transformation of cycloastragenol by the fungi Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552, and the bacterium Mycobacterium sp. NRRL 3805 were investigated. Both fungi mainly provided hydroxylated metabolites together with products formed by cyclization, dehydrogenation and Baeyer-Villiger oxidation resulting in a ring cleavage. The bacteria yielded only a single oxidation product, namely, 3-oxo-cycloastragenol. Structures of the metabolites were elucidated by 1-D ((1)H,(13)C), 2-D NMR (COSY, HMBC, HMQC) and HRMS analyses.
Ege University, Faculty of Engineering, Department of Bioengineering, 35100 Bornova, İzmir, Turkey.
Melis
M
Kuban
Gaye
G
Öngen
Ikhlas A
IA
Khan
Erdal
E
Bedir
D001711:Biotransformation; D020093:Cunninghamella / Q000737:chemistry* / Q000378:metabolism; D005658:Fungi / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009161:Mycobacterium / Q000737:chemistry* / Q000378:metabolism*; D020081:Phyllachorales / Q000737:chemistry* / Q000378:metabolism; D012502:Sapogenins / Q000737:chemistry* / Q000378:metabolism
D012502:Sapogenins; C061014:cycloastragenol