Pharmaceutically versatile sulfated polysaccharide based bionano platforms.
Sulfated polysaccharides are complex polysaccharide molecules with excellent physico-chemical properties and bioactivities. On the basis of origin, they are classified as plant, animal, microbial and chemically synthesized sulfated polysaccharides. They have been widely applied in the fields of material and biological sciences. Biocompatibility and biodegradability of these molecules facilitate their increased use in the nanoparticle synthesis and tissue engineering applications. This review focuses on the structure, function and applications of important types of natural and chemically derived sulfated polysaccharides in the fields of nanotechnology and biomedical sciences. In the first part, we discuss the classification and role of sulfated polysaccharides in various fields. Later, we elaborate the specific bionano applications of commercially important sulfated polysaccharides in ionic gelation, stabilizing, cross-linking, capping and encapsulation of drugs. Finally, we conclude with the future scope and advanced applications of sulfated polysaccharides in various fields of interdisciplinary science.


BACKGROUND
This comprehensive review focuses on the structure, function, and applications of natural and chemically derived sulfated polysaccharides in the fields of nanotechnology and biomedical sciences.
Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama, Japan.
Sreejith
S
Raveendran
Yasuhiko
Y
Yoshida
Toru
T
Maekawa
D Sakthi
DS
Kumar
D020811:Biomedical Technology; D016503:Drug Delivery Systems; D006801:Humans; D036103:Nanotechnology; D011134:Polysaccharides / Q000737:chemistry* / Q000145:classification; D013431:Sulfates / Q000737:chemistry; D023822:Tissue Engineering
D011134:Polysaccharides; D013431:Sulfates