Muscular effects of statins in the elderly female: a review.
Statins have demonstrated substantial benefits in supporting cardiovascular health. Older individuals are more likely to experience the well-known muscle-related side effects of statins compared with younger individuals. Elderly females may be especially vulnerable to statin-related muscle disorder. This review will collate and discuss statin-related muscular effects, examine their molecular and genetic basis, and how these apply specifically to elderly women. Developing strategies to reduce the incidence of statin-induced myopathy in older adult women could contribute to a significant reduction in the overall incidence of statin-induced muscle disorder in this vulnerable group of patients. Reducing statin-related muscle disorder would likely improve overall patient compliance, thereby leading to an increase in improved short- and long-term outcomes associated with appropriate use of statins.
Griffin Hospital, Derby, CT, USA.
Shilpa
S
Bhardwaj
Shalini
S
Selvarajah
Eric B
EB
Schneider
D000368:Aged; D000375:Aging / Q000502:physiology*; D016923:Cell Death; D015897:Comorbidity; D004347:Drug Interactions; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D015994:Incidence; D009135:Muscular Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics; D009220:Myositis / Q000139:chemically induced / Q000453:epidemiology; D011106:Polyisoprenyl Phosphates / Q000096:biosynthesis; D011788:Quality of Life; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000453:epidemiology; D012717:Sesquiterpenes; D012737:Sex Factors; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000096:biosynthesis
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011106:Polyisoprenyl Phosphates; D012717:Sesquiterpenes; D014451:Ubiquinone; C015234:geranyl pyrophosphate; C004808:farnesyl pyrophosphate; C024989:coenzyme Q10
elderly; epidemiology; females; older adults; statins