Development, optimization and in vitro-in vivo evaluation of pioglitazone- loaded jackfruit seed starch-alginate beads.
The present investigation describes development and optimization of pioglitazone-loaded jackfruit seed starch (JFSS)-alginate beads by ionotropic-gelation using 3(2) factorial design. The effect of polymer-blend ratio and CaCl2 concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release after 10 hours (R10h, %) was optimized. The DEE (%) of these beads were 64.80 ± 1.92 to 94.07 ± 3.82 % with sustained in vitro drug release of 64.± 1.83 to 92.66 ± 4.54 % over 10 hours. The in vitro drug release from these beads followed controlled-release pattern with super case-II transport. Particle size range of these beads was 0.77 ± 0.04 to 1.24 ± 0.09 mm. The beads were also characterized by SEM and FTIR. The swelling of these beads was influenced by pH of the test medium. The optimized pioglitazone-loaded JFSS-alginate beads showed significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.
Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj-757086, Odisha, India.. amitkrnayak@yahoo.co.in.
Amit Kumar
AK
Nayak
Dilipkumar
D
Pal
Saquib Md
SM
Hasnain
D000464:Alginates / Q000737:chemistry*; D000818:Animals; D031622:Artocarpus; D001786:Blood Glucose / Q000032:analysis; D002122:Calcium Chloride / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D005260:Female; D005638:Fruit; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000737:chemistry*; D008297:Male; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D000077205:Pioglitazone; D051381:Rats; D012639:Seeds; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000737:chemistry*; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000737:chemistry*
D000464:Alginates; D001786:Blood Glucose; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D020723:Glucuronic Acid; D013213:Starch; D002122:Calcium Chloride; D000077205:Pioglitazone