Bilateral globus pallidus internus deep brain stimulation in Parkinson's disease with periodic limb movement disorder.
Deep brain stimulation for Parkinson's disease is a well-established therapeutic     intervention for refractory disease. The main nuclear targets are the     subthalamic nucleus and the globus pallidus internus. Periodic limb movements     are often an associated condition in patients with Parkinson's disease. Both     conditions can respond to dopaminergic agents. The case of a 57-year-old man     with severe Parkinson's disease and periodic limb movement who underwent     bilateral globus pallidus deep brain stimulation surgery for his Parkinson's     disease is presented and discussed. Intraoperatively the patient's periodic limb     movements responded to voltage stimulation higher than those required for     improvement of his parkinsonian symptoms. The immediate and reversible     improvement in these symptoms contralateral to the stimulation site suggests     pallidal stimulation may directly ameliorate periodic limb movement symptoms.
Mayo Clinic Arizona, Department of Neurology , Phoenix, AZ, USA.
Bryan T
BT
Klassen
Mark K
MK
Lyons
Virgilio Gerald H
VG
Evidente
D046690:Deep Brain Stimulation / Q000379:methods*; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020189:Nocturnal Myoclonus Syndrome / Q000628:therapy*; D010300:Parkinson Disease / Q000628:therapy*; D016896:Treatment Outcome