[Adhesion of T cells and macrophages to the coronary artery endothelium in patients with coronary heart disease].
The study has found a close relationship between the early signs of atherosclerosis, i.e. between the fine-dropwise (dust-like) lipid deposition in the intima and the adhesion of monocyte clusters to the endothelium in these places. In the intimal areas without lipid depositions, adherent monocytes were absent or detectable as single cells in the field of vision. The coronary arteries displayed large clusters of T cells (CD4, CD8) adhered to the endothelium and migrated into the intima. The clusters of these cells were encountered not only in the vascular atherosclerotic lesion areas, but also in the invisibly altered ones. Some patients (with atheromas and fibroatheromas in the coronary artery segments) were found to have en face specimens with endothelial layer damages, with one or 3-5 cells being absent in the endothelial layer. The bottom of such microerosions was lined by T-cell and macrophage infiltrations and it was part of the cap of an atherosclerotic plaque. These surface erosions may be considered as an early developmental stage of an unstable plaque.
P V
PV
Chumachenko
D M
DM
Galiautdinov
R S
RS
Akchurin
V S
VS
Zhdanov
D000368:Aged; D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology; D002448:Cell Adhesion; D003327:Coronary Disease / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D003331:Coronary Vessels / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D008264:Macrophages / Q000166:cytology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology / Q000378:metabolism; D058226:Plaque, Atherosclerotic / Q000378:metabolism / Q000473:pathology; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism; D017539:Tunica Intima / Q000378:metabolism / Q000473:pathology
D008055:Lipids