A genomic day in the life of a clinical microbiology laboratory.
Next-generation sequencing technology is available to many clinical laboratories; however, it is not yet widely used in routine microbiology practice. To demonstrate the feasibility of using whole-genome sequencing in a routine clinical microbiology workflow, we sequenced the genome of every organism isolated in our laboratory for 1 day.
Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas, USA.
S Wesley
SW
Long
Dawn
D
Williams
Chandni
C
Valson
Concepcion C
CC
Cantu
Patricia
P
Cernoch
James M
JM
Musser
Randall J
RJ
Olsen
D001419:Bacteria / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology; D001431:Bacteriological Techniques / Q000379:methods*; D016680:Genome, Bacterial; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods*