Quantitative assessment of systolic and diastolic left ventricular twist using Fourier Analysis of Stimulated echoes (FAST) and CSPAMM.
OBJECTIVE
To evaluate Fourier Analysis of Stimulated echoes (FAST) and CSPAMM for the quantification of left ventricular (LV) systolic and diastolic function and compare it with the previously validated FAST+SPAMM technique.


METHODS
LV short-axis tagged images were acquired with CSPAMM and SPAMM in healthy volunteers (n = 13). The FAST method was used to automatically estimate LV systolic and diastolic twist parameters from rotation of the stimulated echo and stimulated anti-echo about the middle of k-space subsequent to ∼3 min of user interaction.


RESULTS
There was no significant difference between measures obtained for FAST+CSPAMM and FAST+SPAMM for mean peak twist (13.5 ± 2.7° versus 11.9 ± 4.0°), torsion (3.4 ± 0.8°/cm versus 2.9 ± 1.0°/cm), twisting rate (76.8 ± 22.2°/s versus 68.2 ± 23.4°/s), untwisting rate (-102.7 ± 24.6°/s versus -106.6 ± 32.4°/s), normalized untwisting rate (-7.9 ± 2.2/s versus -9.9 ± 4.4/s), and time of peak twist (279 ± 23 ms versus 293 ± 25 ms) (all P > 0.01). FAST+CSPAMM also provided measures of duration of untwisting (148 ± 21 ms) and the ratio of rapid untwist to peak twist (0.8 ± 0.3). Bland-Altman analysis of FAST+CSPAMM and FAST+SPAMM twist data demonstrates excellent agreement with a bias of 1.1° and 95% confidence intervals of [-3.3°, 5.2°].


CONCLUSIONS
FAST+CSPAMM is a semi-automated method that provides a quick and quantitative assessment of LV systolic and diastolic twist and torsion.
Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California 90095-7206, USA. meral@ucla.edu
Meral
M
Reyhan
Daniel B
DB
Ennis
D000328:Adult; D003971:Diastole; D005260:Female; D005583:Fourier Analysis; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012119:Respiration; D013599:Systole; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology; D055815:Young Adult