Cortisone in hair of elementary school girls and its relationship with childhood stress.
Children may be exposed to stressful situations with adverse effects on their physiological and psychological health. As cortisone may be a useful additional biomarker for stress research and as it has been shown to be detectable in human hair, this study measured physiological concentrations of hair cortisone in 223 elementary school girls and explored its relationship with child-reported estimates of stress, more specifically questionnaires on major life events (i.e., Coddington Life Events Scale for Children), emotions (i.e., anger, anxiety, sadness, and happiness), and coping strategies (i.e., emotion- versus problem-focused coping). Cortisone concentrations were positively correlated with the overall life event score for the past 6 months (rho = 0.223, p = 0.004), as well as with the negative event score for this period (rho = 0.227, p = 0.003; N = 165). Cortisone did not correlate with emotions or coping styles reported by the children.


CONCLUSIONS
Despite its exploratory nature, this study may suggest elevated hair cortisone concentrations under psychosocial stress in young children. Although the observed findings should be interpreted with prudence, this study may encourage further research elucidating the potential importance and relevance of hair cortisone analysis as an additional or substituting stress biomarker for hair cortisol.
Department of Public Health, Ghent University Hospital, 2 Block A, 2nd floor, De Pintelaan 185, 9000 Ghent, Belgium. barbara.vanaelst@ugent.be
Barbara
B
Vanaelst
Nathalie
N
Michels
Tineke
T
De Vriendt
Inge
I
Huybrechts
Krishna
K
Vyncke
Isabelle
I
Sioen
Karin
K
Bammann
Noellie
N
Rivet
Jean-Sebastien
JS
Raul
Denes
D
Molnar
Stefaan
S
De Henauw
D000223:Adaptation, Psychological; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003348:Cortisone / Q000378:metabolism*; D005260:Female; D006197:Hair / Q000378:metabolism*; D006801:Humans; D008016:Life Change Events; D011581:Psychological Tests; D057566:Self Report; D013315:Stress, Psychological / Q000378:metabolism*; D011795:Surveys and Questionnaires
D015415:Biomarkers; D003348:Cortisone