Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009.
In 2009, the first outbreak of hand, foot and mouth disease (HFMD) or herpangina (HP) caused by enterovirus 71 occurred in the Republic of Korea. This study inquired into risk factors associated with complications of HFMD or HP. A retrospective medical records review was conducted on HFMD or HP patients for whom etiologic viruses had been verified in 2009. One hundred sixty-eight patients were examined for this investigation. Eighty patients were without complications while 88 were accompanied by complications, and 2 had expired. Enterovirus 71 subgenotype C4a was the most prevalent in number with 67 cases (54.9%). In the univariate analysis, the disease patterns of HFMD rather than HP, fever longer than 4 days, peak body temperature over 39℃, vomiting, headache, neurologic signs, serum glucose over 100 mg/dL, and having an enterovirus 71 as a causative virus were significant risk factors of the complications. After multiple logistic analysis, headache (Odds ratio [OR], 10.75; P < 0.001) and neurologic signs (OR, 42.76; P < 0.001) were found to be the most significant factors. Early detection and proper management of patients with aforementioned risk factors would be necessary in order to attain a better clinical outcome.
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Seong Joon
SJ
Kim
Jong-Hyun
JH
Kim
Jin-Han
JH
Kang
Dong Soo
DS
Kim
Ki Hwan
KH
Kim
Kyung-Hyo
KH
Kim
Young-Hoon
YH
Kim
Ju-Young
JY
Chung
Joong Hyun
JH
Bin
Da Eun
DE
Jung
Ji Hong
JH
Kim
Hwang Min
HM
Kim
Doo-Sung
DS
Cheon
Byung Hak
BH
Kang
Soon Young
SY
Seo
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001831:Body Temperature; D029821:Enterovirus A, Human / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005334:Fever / Q000209:etiology; D005838:Genotype; D006232:Hand, Foot and Mouth Disease / Q000150:complications* / Q000821:virology; D006261:Headache / Q000209:etiology; D006557:Herpangina / Q000150:complications* / Q000821:virology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D014839:Vomiting / Q000209:etiology; D055815:Young Adult
D001786:Blood Glucose
Coxsackievirus; Enterovirus A, Human; Hand, Foot and Mouth Disease; Herpangina; Risk Factors