Features and predictors of myocardial injury in carbon monoxide poisoned patients.
OBJECTIVE
By contrast with neurologic injury, myocardial injury associated with carbon monoxide (CO) poisoning has not been well investigated. Therefore, this study assessed features and predictors of myocardial injury in CO poisoned patients.


METHODS
250 CO poisoning cases that were diagnosed and treated by the emergency department of Wonju Christian Hospital from January 2006 to February 2012 were retrospectively reviewed.


RESULTS
Fifty (20%) out of 250 patients with CO poisoning developed myocardial injury. Among those with elevated troponin I (Tn I), peak levels occurred at 11.0 (IQR, 4.5-18.5) h normalising by 65.0 (IQR 44.0-96.0) h. CO exposure time, and total and ICU admission length was longer (7.5 (IQR 3.7-10.0) h vs 3.0 (IQR 1.0-7.5) h, p<0.001; 3.5 (IQR 0.0-7.0) days and 0.0 (IQR 0.0-1.25) days vs 0.0 (IQR 0.0-2.0) days and 0.0 (IQR 0.0-0.0) days, p<0.001, respectively) in the myocardial vs non-myocardial injury group. The predictors of myocardial injury were male gender, Glasgow Coma Scale (GCS) ≤14, and CO exposure time ≥2 h (OR (95% CI) of 3.341 (1.171 to 9.531), 9.920 (3.763 to 26.150), and 7.743 (1.610 to 37.238), respectively).


CONCLUSIONS
Myocardial injury developed in 20% of CO poisoned patients. Time to normalisation and of peak Tn I level in elevated Tn I group was 65.0 (IQR 44.0-96.0) h and 11.0 (IQR 4.5-18.5) h. Presence of myocardial injury was associated with poorer prognosis. Predictors of myocardial injury included male gender, GCS of 14 or less, or CO exposure times greater than 2 h.
Department of Emergency Medicine, Wonju College of Medicine, Yonsei University, , Wonju city, Kangwon Province, Republic of Korea.
Yong Sung
YS
Cha
Kyoung Chul
KC
Cha
Oh Hyun
OH
Kim
Kang Hyun
KH
Lee
Sung Oh
SO
Hwang
Hyun
H
Kim
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D009202:Cardiomyopathies / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007723:Korea; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D019210:Troponin I / Q000097:blood; D055815:Young Adult
D015415:Biomarkers; D019210:Troponin I
environmental medicine