[Strategies to avoid antibiotic resistance].
Antibiotics are used very frequently in critically ill patients as a causal and often life-saving treatment; however, the high density of use of broad spectrum antibiotics contributes to a further deterioration in resistance trends, which makes a rational prescription behavior mandatory. This particularly includes measures which lead to the reduction of antibiotic use, i.e. rigorous indications, targeted de-escalation and limited duration. For optimal efficacy of a necessary treatment the integration of pharmacokinetic and pharmacodynamic principles can be helpful.
Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin. martin.kees@charite.de
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D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D003428:Cross Infection / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D004334:Drug Administration Schedule; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D004363:Drug Utilization / Q000639:trends; D005544:Forecasting; D005858:Germany; D006801:Humans; D007362:Intensive Care Units; D008657:Metabolic Clearance Rate / Q000502:physiology; D008826:Microbial Sensitivity Tests; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents