[Effect of borneol on intestinal absorption of muscone in rats].
OBJECTIVE
To explore the influence of borneol on intestinal absorption of muscone in rats.


METHODS
An in situ intestinal circulation perfusion experiment was used to study the changes in intestinal absorption kinetics of muscone before and after being compatible with borneol.


RESULTS
Compared with the muscone group (MG), the absorption rate constants (Ka), the half-life period (T1/2) and the absorption rate (A) of muscone in the borneol + muscone group (BMG) were on the rise, but with no significant difference; after being compatible with borneol for a long period, Ka, T1/2 and A in the last borneol on muscone group (LBMG) increased, with significant difference (P < 0.05). in duodenum, LBMG showed better effects than MG (T1/2, P < 0.05); and so did in jejunum (Ka, P < 0.05; T1/2, P < 0.05); in ileum, there was no significant statistical difference between LBMG and MG.


CONCLUSIONS
Borneol can promote the intestinal absorption of muscone in rats to some extent.
College of Biological Industry, Chengdu University, Chengdu 610106, China. zouliang@cdu.edu.cn
Liang
L
Zou
Jun-Zhi
JZ
Lin
Hui-Ling
HL
Hu
Ying
Y
Wang
Ping
P
Wang
Gang
G
Zhao
Zhan-Guo
ZG
Wang
D000818:Animals; D001892:Camphanes / Q000494:pharmacology*; D003516:Cycloparaffins / Q000493:pharmacokinetics*; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001892:Camphanes; D003516:Cycloparaffins; D004365:Drugs, Chinese Herbal; C022871:isoborneol; C031021:muscone