[Bronchial hyperresponsiveness and factors of bronchial inflammation under the exercise-induced asthma in schoolchildren].
88 schoolchildren with bronchial asthma were observed at the department of pulmonary disease and allergology of the Chernivtsi regional children clinical hospital. The study showed that the content of aldehyde- and ketoderivatives of 2,4-dinitrophenylhydrazones of neutral character in the expired air condensate (AKDNPH) was presumably higher in patients with the exercise-induced bronchial asthma thus indicating the more significant activity of the inflammatory process in bronchi under the studied phenotype of the disease. Non-specific bronchial hyperresponsiveness was presumably higher in children suffering exercise-induced bronchial asthma due to bronchial hyperresponsiveness as well as hyperreactivity when compared with the patients having activity independent asthma attacks. The factor of bronchial spasm was significantly associated with the content of AKDNPH of the basic character and nitric oxide metabolites in the expired air condensate in the patients with the exercise-induced bronchial asthma.
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Ivanova
D000293:Adolescent; D001250:Asthma, Exercise-Induced / Q000378:metabolism* / Q000503:physiopathology; D001980:Bronchi / Q000378:metabolism* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000378:metabolism* / Q000503:physiopathology; D001986:Bronchial Spasm / Q000378:metabolism* / Q000503:physiopathology; D002374:Catalase / Q000378:metabolism; D002648:Child; D045853:Exhalation; D005260:Female; D006801:Humans; D006835:Hydrazones / Q000032:analysis; D007249:Inflammation / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism; D012129:Respiratory Function Tests; D013334:Students
C001072:2,4-dinitrophenylhydrazone; D006835:Hydrazones; D011506:Proteins; D009569:Nitric Oxide; D002374:Catalase