A high-value, low-cost bubble continuous positive airway pressure system for low-resource settings: technical assessment and initial case reports.
Acute respiratory infections are the leading cause of global child mortality. In the developing world, nasal oxygen therapy is often the only treatment option for babies who are suffering from respiratory distress. Without the added pressure of bubble Continuous Positive Airway Pressure (bCPAP) which helps maintain alveoli open, babies struggle to breathe and can suffer serious complications, and frequently death. A stand-alone bCPAP device can cost $6,000, too expensive for most developing world hospitals. Here, we describe the design and technical evaluation of a new, rugged bCPAP system that can be made in small volume for a cost-of-goods of approximately $350. Moreover, because of its simple design--consumer-grade pumps, medical tubing, and regulators--it requires only the simple replacement of a <$1 diaphragm approximately every 2 years for maintenance. The low-cost bCPAP device delivers pressure and flow equivalent to those of a reference bCPAP system used in the developed world. We describe the initial clinical cases of a child with bronchiolitis and a neonate with respiratory distress who were treated successfully with the new bCPAP device.
Department of Bioengineering, Rice University, Houston, Texas, United States of America.
Jocelyn
J
Brown
Heather
H
Machen
Kondwani
K
Kawaza
Zondiwe
Z
Mwanza
Suzanne
S
Iniguez
Hans
H
Lang
Alfred
A
Gest
Neil
N
Kennedy
Robert
R
Miros
Rebecca
R
Richards-Kortum
Elizabeth
E
Molyneux
Maria
M
Oden
D000208:Acute Disease; D001988:Bronchiolitis / Q000473:pathology / Q000628:therapy*; D045422:Continuous Positive Airway Pressure / Q000191:economics / Q000295:instrumentation*; D003906:Developing Countries; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010102:Oxygen Inhalation Therapy / Q000191:economics / Q000295:instrumentation*; D012127:Respiratory Distress Syndrome, Newborn / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome