Merckel cell carcinoma: the impact of multidisciplinary management.
Merkel cell carcinoma (MMC) is a rare primary neuroendocrine skin tumor associated with a poor prognosis. MMC is histologically similar to small cell lung carcinoma. The incidence of MCC is increasing with a median age of discovery of approximately 70 years old. Treatment of MCC, which usually occurs in sun-exposed skin, includes surgery with reconstruction associated with radiotherapy and/or chemotherapy for advanced stages including widespread metastases. We report two cases of Merkel cell carcinoma in 76 and 84 year old patients and describe the natural history of this cancer and management in geriatric patients. Merkel cell carcinoma (MCC) is a rare cancer with high malignant potential that mainly affects people over the age of 65. It must be diagnosed early to improve the prognosis. The survival rate at 5 years for local or regional invasion is 65%. The median survival for metastasized stages is 10 months. The therapeutic regimen recommended for the treatment of MCC is influenced by the geriatric status of patients, and a multidisciplinary oncogeriatric approach could be of interest.
Geriatrics Department, Rouen University Hospital, Rouen, France.
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S
Miranda
X
X
Gbaguidi
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P
Carvalho
J
J
Chassagne
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015266:Carcinoma, Merkel Cell / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D010348:Patient Care Team; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate