IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection.
Interleukin (IL)-21 may affect both T-cell and B-cell responses and was suggested to be involved in response to HBV infection. This study explored IL21rs907715 and rs2221903 and IL21R T-83C and rs3093301 polymorphisms and serum IL-21 and IgE levels in 395 patients with chronic HBV infection, 75 HBV infection resolvers and 174 healthy controls. IL21R T-83C was not polymorphic in the study populations. IL21 rs2221903 AG was less frequent in HBV patients than in resolvers (p<0.001, OR=0.364, 95% CI=0.211-0.629) or in controls (p=0.017, OR=0.589, 95% CI=0.381-0.911). IL21R rs3093301 TT was more frequent in HBV patients than in controls [p value after Bonferroni correction (pc)=0.022, OR=1.908, 95% CI=1.158-3.142] and more frequent in resolvers than in controls (pc=0.010, OR=2.965, 95% CI 1.375-6.392). The carriage of IL21 rs2221903 AG/IL21R rs3093301 CT+IL21 rs2221903 AG/IL21R rs3093301 TT was less frequent in patients than in resolvers (pc=0.007, OR=0.236, 95% CI=0.096-0.579) and more frequent in resolvers than in controls (pc=0.014, OR=4.354, 95% CI=1.660-11.420). IL21 rs2221903 was, by interaction with IL21R rs3093301, associated with serum IL-21 and IgE levels in HBV patients. It is suggested that IL21 rs2221903 and IL21R rs3093301 polymorphisms may, independently or interactively, affect the susceptibility to and/or persistence of HBV infection potentially through altering IL-21 and IgE production.
Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi' an, Shaanxi Province, China.
Na
N
Li
Qianqian
Q
Zhu
Zhu
Z
Li
Qunying
Q
Han
Jinghong
J
Chen
Yi
Y
Lv
Yawen
Y
Wang
Xiaoyan
X
Zeng
Yanping
Y
Chen
Cuiling
C
Yang
Zhengwen
Z
Liu
D000328:Adult; D000483:Alleles; D004843:Epistasis, Genetic; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000097:blood / Q000235:genetics* / Q000821:virology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007378:Interleukins / Q000097:blood / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D053655:Receptors, Interleukin-21 / Q000235:genetics*; D055815:Young Adult; D000098546:Interleukin-21
D007378:Interleukins; D053655:Receptors, Interleukin-21; D007073:Immunoglobulin E; D000098546:Interleukin-21