Location, location, location: it's all in the timing for replication origins.
The differential replication timing of eukaryotic replication origins has long been linked with epigenetic regulation of gene expression and more recently with genome stability and mutation rates; however, the mechanism has remained obscure. Recent studies have shed new light by identifying novel factors that determine origin timing in yeasts and mammalian cells and implicate the spatial organization of origins within nuclear territories in the mechanism. These new insights, along with recent findings that several initiation factors are limiting relative to licensed origins, support and shape an emerging model for replication timing control. The mechanisms that control the spatial organization of replication origins have potential impacts for genome regulation beyond replication.
Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089, USA. oaparici@usc.edu
Oscar M
OM
Aparicio
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D002875:Chromosomes / Q000737:chemistry / Q000235:genetics; D004261:DNA Replication / Q000502:physiology*; D042522:DNA Replication Timing; D006801:Humans; D018741:Replication Origin / Q000235:genetics*; D013995:Time
D018797:Cell Cycle Proteins