Effects of type of diet on pharmacokinetics of levothyroxine sodium oral solution.
The pharmacokinetics of serum total thyroxine concentration (TT4) in euthyroid dogs was studied after concomitant administration of a levothyroxine oral solution with different types of dry diet. Mixing levothyroxine with different types of dry diet did not have any effect on TT4 pharmacokinetics in the dogs (Cmax 50.6 nmol/L, tmax 4.0 h and AUC 517 nmol h/L). This finding indicates that changing from one diet to another during levothyroxine-replacement therapy should not impact therapeutic effectiveness, and should be helpful for improvement of compliance with thyroid hormone replacement therapy in dogs treated for life with this replacement therapy.
Intervet K.K. Central Research Laboratories, 1103 Fukaya, Kasumigaura-shi, Ibaraki 300-0134, Japan. ryuji.iemura@merck.com
Ryuji
R
Iemura
Masanori
M
Toyota
Mark J
MJ
Micallef
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D004032:Diet / Q000662:veterinary*; D004285:Dogs; D005260:Female; D008297:Male; D013974:Thyroxine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D013974:Thyroxine