Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population.
BACKGROUND
Tryptophan hydroxylase-2 (TPH2) is a potential candidate gene for screening tic disorder (TD).


METHODS
A case-control study was performed to examine the association between the TPH2 gene and TD. The Sequenom® Mass ARRAY iPLEX GOLD System was used to genotype two single nucleotide polymorphisms (SNPs) of the TPH2 gene in 149 TD children and in 125 normal controls.


RESULTS
For rs4565946, individuals with the TT genotype showed a significantly higher risk of TD than those with TC plus CC genotypes [odds ratio (OR) =3.077, 95% confidence interval (CI): 1.273-7.437; P = 0.009], as did male TD children with the TT genotype (OR = 3.228, 95% CI: 1.153-9.040; P = 0.020). The G allele of rs4570625 was significantly more frequent in TD children with higher levels of tic symptoms (Yale Global Tic Severity Scale, YGTSS) than those in controls among the male children (OR = 1.684, 95%: 1.097-2.583; P = 0.017]. TD children with severe tic symptoms had significantly higher frequencies of rs4546946 TT genotype than did normal controls in boys (OR = 3.292, 95% CI: 1.139-9.513; P = 0.022). We also found that genotype distributions of both SNPs were different between the Asian and European populations.


CONCLUSIONS
Our results indicated that the TT genotype of rs4565946 is a potential genetic risk factor for TD, and the allele G of rs4570625 might be associated with the severity of tic symptoms in boys. These polymorphisms might be susceptibility loci for TD in the Chinese Han population. Because of the confounding of co-existing attention deficit hyperactivity disorder (ADHD),these findings need to be confirmed by studies in much larger samples.
Department of Neurological medicine, Capital Institute of Pediatrics, Beijing, 100020, China.
Ping
P
Zheng
Erzhen
E
Li
Jianhua
J
Wang
Xiaodai
X
Cui
Liwen
L
Wang
D017668:Age of Onset; D000483:Alleles; D000818:Animals; D044466:Asian People / Q000235:genetics; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications; D001665:Binding Sites; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000453:epidemiology; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D003627:Data Interpretation, Statistical; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D013981:Tic Disorders / Q000453:epidemiology* / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism; D014365:Tryptophan Hydroxylase / Q000235:genetics*
D014157:Transcription Factors; D004247:DNA; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase