Developments in the identification of glycan biomarkers for the detection of cancer.
Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent advances in the development of analytical techniques and instrumentation, especially in mass spectrometry, it is now possible to identify blood-derived glycan-based biomarkers using glycomics strategies. This review is an overview of the developments made in the search for glycan-based cancer biomarkers and the technologies currently in use. It is anticipated that the progressing instrumental and bioinformatics developments will allow the identification of relevant glycan biomarkers for the diagnosis, early detection, and monitoring of cancer treatment with sufficient sensitivity and specificity for clinical use.
Department of Chemistry, University of California Davis, Davis, California 95616, USA.
L Renee
LR
Ruhaak
Suzanne
S
Miyamoto
Carlito B
CB
Lebrilla
D000818:Animals; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood* / Q000737:chemistry / Q000302:isolation & purification; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006023:Glycoproteins / Q000097:blood* / Q000737:chemistry / Q000302:isolation & purification; D006031:Glycosylation; D006801:Humans; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis*; D011134:Polysaccharides / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification; D011379:Prognosis; D011499:Protein Processing, Post-Translational; D020543:Proteome / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism
D015295:Antigens, Tumor-Associated, Carbohydrate; D006023:Glycoproteins; D011134:Polysaccharides; D020543:Proteome