Association of serum immunoglobulins levels and eye injuries in sulfur mustard exposed: Sardasht-Iran Cohort Study.
In this study the associations between ocular problems and serum levels of immunoglobulins in sulfur mustard (SM) exposed population 20 years after exposure in context of Sardasht-Iran Cohort Study was explored. Serum immunoglobulins (Ig) levels including IgM, IgA, IgE, IgG, and subclasses of IgG (IgG1, IgG2, IgG3 and IgG4) in 372 SM-exposed patients were titrated and compared with 128 unexposed controls considering their ocular problems. In exposed patients with tearing and blurring of vision, serum IgM levels were significantly lower than matched controls (P=0.026 and 0.027, respectively). Serum IgM levels in exposed patients with normal ocular conditions were significantly lower (P<0.050) than that of matched controls. Serum levels of IgA, IgE and IgG and IgG3 levels were not significantly different between the two groups with abnormal and normal ocular conditions. Mean serum IgG1 levels in exposed patients with normal ocular conditions were significantly higher than the matched controls (P<0.05) except for tearing and photophobia. Mean serum IgG2 levels in exposed with blurring of vision and without tearing, ocular pain, photophobia, lids and bulbar conjuctival abnormalities were significantly higher than that of matched controls (P<0.050). Mean serum levels of IgG4 in exposed patients with normal ocular conditions and most of the abnormal ocular conditions were significantly lower than the matched controls (P<0.05). The results of the current study showed that even 20 years after SM exposure serum immunoglobulins are different from matched normal controls and the levels of IgM and IgG4 are associated with some aspects of ocular surface problems.
Immunoregulation Research Center, Shahed University, Tehran, Islamic Republic of Iran; Department of Ophthalmology, Shahed University, Tehran, Islamic Republic of Iran.
Hassan
H
Ghasemi
Ail
A
Mostafaie
Roya
R
Yaraee
Zuhair Mohammad
ZM
Hassan
Abbas
A
Rezaei
Mahmoud
M
Mahmoudi
Soghrat
S
Faghihzadeh
Mohammad-Reza
MR
Soroush
Sussan K
SK
Ardestani
Mahmoud
M
Babaei
Mohammadreza
M
Jalali-Nadoushan
Ali
A
Khamesipour
Mohammad
M
Ghassemi-Broumand
Tooba
T
Ghazanfari
D000328:Adult; D002619:Chemical Warfare Agents / Q000633:toxicity*; D015331:Cohort Studies; D004781:Environmental Exposure / Q000009:adverse effects; D005131:Eye Injuries / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D007492:Iran / Q000453:epidemiology; D008875:Middle Aged; D009151:Mustard Gas / Q000633:toxicity*; D055815:Young Adult
D002619:Chemical Warfare Agents; D007136:Immunoglobulins; D009151:Mustard Gas
Eye; Immune system; Immunoglobulins; Serum; Sulfur mustard