[Relationship of TGF-β and IL-4R gene polymorphisms with risk of classical Hodgkin lymphoma].
OBJECTIVE
This study was aimed to analyze the relationship between single nucleotide polymorphisms of transforming growth factor-β1 G-800A and C-509T, interleukin-4 receptor V75I and susceptibility of CHL in adults.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was applied to analyze the expressed alleles of the selected SNP loca. The relationship between genomic polymorphisms of TGF-β1 and IL-4R and susceptibility of CHL were coupled with clinical data.


RESULTS
TGF-β1G-800A and TGF-β1C-509T had obvious linkage equilibrium (D' = 0.879, r(2) = 0.83, P = 0.020). GT haplotype distribution frequencies in mixed cellularity Hodgkin lymphoma cases and control group were of 53.1% and 34.2%, respectively, with statistically significant (OR = 2.35, P = 0.000); distribution frequencies of mutant gene T/T in disease and control groups were of 38.8% and 15.3%, respectively, also with statistically significant (OR = 3.654, P = 0.000); frequencies of nodular sclerosis CHL patients with IL-4R V75I mutant gene A/A in disease and control groups were of 19.2% and 41.75%, respectively, also with statistically significant (OR = 3.156, P = 0.000).


CONCLUSIONS
Single nucleotide polymorphisms of TGF-β1 G-800A, C-509T and IL-4R V75I has a significant correlation with Chinese susceptibility to classical Hodgkin lymphoma.
Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012, China.
Xin-ru
XR
Wang
Li-zhen
LZ
Li
Tao
T
Huang
Hao
H
Li
Lu-qun
LQ
Wang
Xiang-xin
XX
Li
Fang-lin
FL
Li
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006689:Hodgkin Disease / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000235:genetics*; D055815:Young Adult
D019948:Receptors, Interleukin-4; D016212:Transforming Growth Factor beta