Biomolecule-functionalized polymer brushes.
Functional polymer brushes have been utilized extensively for the immobilization of biomolecules, which is of crucial importance for the development of biosensors and biotechnology. Recent progress in polymerization methods, in particular surface-initiated atom transfer radical polymerization (ATRP), has provided a unique means for the design and synthesis of new biomolecule-functionalized polymer brushes. This current review summarizes such recent research activities. The different preparation strategies for biomolecule immobilization through polymer brush spacers are described in detail. The functional groups of the polymer brushes used for biomolecule immobilization include epoxide, carboxylic acid, hydroxyl, aldehyde, and amine groups. The recent research activities indicate that functional polymer brushes become versatile and powerful spacers for immobilization of various biomolecules to maximize their functionalities. This review also demonstrates that surface-initiated ATRP is used more frequently than other polymerization methods in the designs of new biomolecule-functionalized polymer brushes.
State Key Laboratory of Chemical Resource Engineering, Ministry of Education, College of Materials Science & Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Hui
H
Jiang
Fu-Jian
FJ
Xu
D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D004852:Epoxy Compounds / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D006801:Humans; D006878:Hydroxides / Q000737:chemistry; D055767:Immobilized Proteins / Q000737:chemistry / Q000378:metabolism; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
D000447:Aldehydes; D000588:Amines; D002264:Carboxylic Acids; D004800:Enzymes, Immobilized; D004852:Epoxy Compounds; D005609:Free Radicals; D006878:Hydroxides; D055767:Immobilized Proteins; D011108:Polymers; D011506:Proteins; C031356:hydroxide ion