Recurrent vulvar melanoma in 35-year-old pregnant women.
Vulvar melanoma represents between 3% and 10% of vulvar neoplasms. We present a case of a 34-year-old pregnant woman presenting with a pigmented lesion on the left labium majus; she reported no family history of melanoma. The histological diagnosis was malignant melanoma, superficial spreading type, with Breslow thickness of 0.9 mm; the excision was complete. Eight months before, an atypical genital nevus was completely excised from a nearby location. The pregnancy was finished by cesarean delivery at term, and 3 months later, another pigmented lesion was noticed near but not within the scars. Partial right vulvectomy was performed, and histological diagnosis was malignant melanoma of superficial spreading type, with Breslow thickness of 0.7 mm. The specimen obtained in the first operation was reviewed, and although histological examination was diagnostic for atypical genital nevus, Vysis Melanoma Fluorescence in situ hybridization Probe Kit revealed increased copy numbers of RREB1, which could be consistent with a diagnosis of malignant melanoma.
Department of Pathomorphology, Jagiellonian University Medical College, 31-501 Krakow, Poland.
Grzegorz
G
Dyduch
Robert
R
Jach
Hubert
H
Huras
Małgorzata
M
Radoń-Pokracka
Joanna
J
Szpor
Kazimierz
K
Pityński
Krzysztof
K
Okoń
Krzysztof
K
Zajac
D000328:Adult; D002585:Cesarean Section; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics; D006651:Histocytochemistry; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D011247:Pregnancy; D037841:Pregnant People; D012008:Recurrence; D014157:Transcription Factors / Q000235:genetics; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery
D004268:DNA-Binding Proteins; D020662:Guanine Nucleotide Exchange Factors; C118971:PREB protein, human; D014157:Transcription Factors