[Topical hemoglobin promotes wound healing of patients with venous leg ulcers].
BACKGROUND
Improvement of oxygenation is getting increasing attention as an important aspect in the modern wound care. The aim of such complementary wound care approaches is to improve and accelerate wound healing.


METHODS
A solution comprising purified hemoglobin was added to the standard wound care procedure of patients with venous leg ulcers and compared to a second group without addition of the hemoglobin. In each group, 36 patients were included. The duration of treatment was 13 weeks. Primary end point was reduction of wound size or wound closing.


RESULTS
In the group treated with the additional hemoglobin solution, an average of 53% of wound size reduction was obtained. No statistically significant reduction was observed in the second group.


CONCLUSIONS
The addition of aemoglobin solution in the wound care procedure for venous leg ulcers showed a significant improvement of wound healing in comparison to a control group.
Dermatologische Klinik der Dritten medizinischen Fakultät der Karls-Universität, Ruská 87, 10034 Prag 10, Tschechische Republik. arenbergerova@email.cz
M
M
Arenbergerova
P
P
Engels
S
S
Gkalpakiotis
Z
Z
Dubská
P
P
Arenberger
D000287:Administration, Topical; D003131:Combined Modality Therapy; D003879:Dermatologic Agents / Q000008:administration & dosage; D005260:Female; D006454:Hemoglobins / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000175:diagnosis* / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects*
D003879:Dermatologic Agents; D006454:Hemoglobins