Camellia sinensis (green tea) extract attenuate acrylamide induced testicular damage in albino rats.
Acrylamide is a proved toxin for testicular function, found in food when heated for long period of time. Green tea (Camellia sinensis) is a potent antioxidant; the aim of this study was to investigate the protective effect of green tea extract against the toxic effects of acrylamide in rat testes.


METHODS
acrylamide was administered orally to rats in different doses and also the extract of green tea was administered orally to different groups of animals in combination with the acrylamide. The weight of animals, testosterone hormone level and histopathological effect upon testicles were evaluated.


RESULTS
Testosterone hormone level in serum, and histopathological findings were significantly improved with the co-administration of green tea extract with the acrylamide. Green tea extract reversed all the toxic effects of acrylamide even in high dose for long period (90 days).


CONCLUSIONS
Green tea extract is a potent antioxidant antidote for the acrylamide toxic effects upon testicular function.
Forensic Medicine and Clinical Toxicology department, Faculty of Medicine, Assiut University, Egypt.
Heba A
HA
Yassa
Safaa M
SM
George
Abeer El Refaiy M
Ael R
Refaiy
Effat M Abdel
EM
Moneim
D020106:Acrylamide / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D028241:Camellia sinensis / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea / Q000737:chemistry*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000097:blood
D000975:Antioxidants; D010936:Plant Extracts; D020011:Protective Agents; D013662:Tea; D020106:Acrylamide; D013739:Testosterone
Camellia sinensis; acrylamide; testosterone