The impact of a ketogenic diet and liver dysfunction on serum very long-chain fatty acids levels.
Peroxisomes play an essential role in mammalian cellular metabolism, particularly in oxidation fatty acid pathways. Serum very long-chain fatty acids (VLCFA), the main biochemical diagnostic parameters for peroxisomal disorders, were examined in 25 neurological patients with epilepsy on a ketogenic diet and 27 patients with liver dysfunction. The data show that patients on a ketogenic diet have increased levels of C22:0 and C24:0, but not C26:0, and normal C24:0/C22:0 and C26:0/C22:0. Patients with liver insufficiency showed a slightly elevated level of C26:0, a normal level of C24:0 and a decreased level of C22:0; thus in 21/27 the ratio of C24:0/C22:0 was increased and 15/27 the ratio of C26:0/C22:0 was increased.
Department of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730, Warsaw, Poland. jstradomska@op.pl
T J
TJ
Stradomska
M
M
Bachański
J
J
Pawłowska
M
M
Syczewska
A
A
Stolarczyk
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A
Tylki-Szymańska
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D055423:Diet, Ketogenic; D004827:Epilepsy / Q000097:blood*; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D020675:Peroxisomes / Q000473:pathology; D055815:Young Adult
D005227:Fatty Acids