Cis-regulatory logic in archaeal transcription.
For cellular fitness and survival, gene expression levels need to be regulated in response to a wealth of cellular and environmental signals. TFs (transcription factors) execute a large part of this regulation by interacting with the basal transcription machinery at promoter regions. Archaea are characterized by a simplified eukaryote-like basal transcription machinery and bacteria-type TFs, which convert sequence information into a gene expression output according to cis-regulatory rules. In the present review, we discuss the current state of knowledge about these rules in archaeal systems, ranging from DNA-binding specificities and operator architecture to regulatory mechanisms.
Research group of Microbiology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium. espeeter@vub.ac.be
Eveline
E
Peeters
Nuno
N
Peixeiro
Guennadi
G
Sezonov
D001105:Archaea / Q000235:genetics*; D019641:DNA, Archaeal / Q000235:genetics; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
D019641:DNA, Archaeal