Management of oxidative stress by microalgae.
The aim of this review is to provide an overview of the current research on oxidative stress in eukaryotic microalgae and the antioxidant compounds microalgae utilize to control oxidative stress. With the potential to exploit microalgae for the large-scale production of antioxidants, interest in how microalgae manage oxidative stress is growing. Microalgae can experience increased levels of oxidative stress and toxicity as a result of environmental conditions, metals, and chemicals. The defence mechanisms for microalgae include antioxidant enzymes such as superoxide dismutase, catalase, peroxidases, and glutathione reductase, as well as non-enzymatic antioxidant molecules such as phytochelatins, pigments, polysaccharides, and polyphenols. Discussed herein are the 3 areas the literature has focused on, including how conditions stress microalgae and how microalgae respond to oxidative stress by managing reactive oxygen species. The third area is how beneficial microalgae antioxidants are when administered to cancerous mammalian cells or to rodents experiencing oxidative stress.
Medical Sciences, Northern Ontario School of Medicine, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.
Judith T
JT
Cirulis
J Ashley
JA
Scott
Gregory M
GM
Ross
D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D004785:Environmental Pollutants / Q000633:toxicity; D058086:Microalgae / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D054811:Phytochelatins / Q000378:metabolism; D010860:Pigments, Biological / Q000378:metabolism; D059808:Polyphenols / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D004785:Environmental Pollutants; D010860:Pigments, Biological; D059808:Polyphenols; D017382:Reactive Oxygen Species; D054811:Phytochelatins; D002374:Catalase; D013482:Superoxide Dismutase