Evaluation of a single-channel nasal pressure device to assess obstructive sleep apnea risk in laboratory and home environments.
OBJECTIVE
To evaluate the sensitivity and specificity of a portable single-channel (intra-nasal pressure) sleep apnea device (ApneaLink) in both the laboratory and at home for assessment of sleep apnea risk in comparison with standard polysomnography (PSG).


METHODS
Fifty-five participants underwent simultaneous recordings of standard PSG and ApneaLink in the laboratory. Of these, 38 participants also used the ApneaLink device in their own homes for one night. PSG respiratory events were scored using standard criteria. Intra-nasal pressure signals were analyzed using the ApneaLink automated computerized algorithm provided to yield estimates of airflow for detection of apneas and hypopneas. Apnea-hypopnea indices (AHI) were compared.


RESULTS
There was high sensitivity and specificity for the ApneaLink AHI when compared to simultaneous PSG at comparable AHI levels (AHI ≥ 15 events/h; sensitivity 100%, specificity 92%; positive and negative predictive values 70% and 100%, respectively). Home-measured ApneaLink AHI sensitivity and specificity were also reliable when compared with PSG (AHI ≥ 5, 81% and 77%, respectively; AHI ≥ 15, 67% and 91%), and improved slightly when two nights' data were used (AHI ≥ 5, 88% and 85%; AHI ≥ 15, 67% and 93%).


CONCLUSIONS
The ApneaLink demonstrated good sensitivity and specificity in quantifying AHI when compared to PSG in a population with and without confirmed OSA. This simple, easy-to-use device may be useful in de novo large-scale occupational or underserved community OSA diagnostic programs to identify those with unambiguous disease who need immediate treatment or indicate those who may be at increased risk of OSA.
Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Kate E
KE
Crowley
Shantha M W
SM
Rajaratnam
Steven A
SA
Shea
Lawrence J
LJ
Epstein
Charles A
CA
Czeisler
Steven W
SW
Lockley
D056044:Actigraphy / Q000379:methods; D000328:Adult; D003430:Cross-Sectional Studies; D004867:Equipment Design; D004869:Equipment Safety; D005260:Female; D006701:Home Nursing; D006801:Humans; D007753:Laboratories; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000295:instrumentation* / Q000379:methods; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D017286:Polysomnography / Q000379:methods; D012372:ROC Curve; D025363:Rhinomanometry / Q000295:instrumentation* / Q000379:methods; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000628:therapy