Phenolic glycosides from Curculigo orchioides Gaertn.
Five new chlorophenolic glucosides, curculigine E (1), curculigine F (2), curculigine G (3), curculigine H (5), curculigine I (6) and one new phenolic glycoside, orcinoside H (4), together with eight known phenolic glycosides (7-14) were isolated from the Curculigo orchioides Gaertn. Their structures were established by spectroscopic techniques (IR, UV, MS, 1D and 2D NMR). The isolated phenolic glycosides were evaluated for antiosteoporotic activity against MC3T3-E1 cell line using MTT assays. Compounds 1, 2, 3, and 5 showed moderate antiosteoporotic activity with the proliferation rate of 10.1-14.1%.
School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Zhen-Hui
ZH
Wang
Jian
J
Huang
Xiao-Ci
XC
Ma
Guo-Yu
GY
Li
Yue-Ping
YP
Ma
Ning
N
Li
Jin-Hui
JH
Wang
D000818:Animals; D050071:Bone Density Conservation Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D002460:Cell Line; D031408:Curculigo / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D015394:Molecular Structure; D010006:Osteoblasts / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D027343:Rhizome
D050071:Bone Density Conservation Agents; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D010636:Phenols