Influence of admixture components on CYP2C9*2 allele frequency in eight indigenous populations from Northwest Mexico.
We previously documented the lowest frequency of CYP2C9*2 in Mexican indigenous Tepehuanos followed by Mestizos and Mexican-Americans populations, suggesting a negative correlation between the CYP2C9*2 frequency and the degree of Asian ancestry in indigenous Americans. We determined the influence of ethnic admixture components on the CYP2C9 allele distribution in 505 Amerindian from eight indigenous populations through genotyping CYP2C9*2, *3 and *6 alleles by real-time PCR and molecular evaluation of ancestry. The frequencies for CYP2C9*2 were 0.026 in Seris and 0.057 in Mayos, being higher than in Asians (P<0.001). CYP2C9*3 was found in Tarahumaras (0.104), Mayos (0.091), Tepehuanos (0.075), Guarijíos (0.067), Huicholes (0.033) and Coras (0.037), with East Asians having lower frequencies than the former three groups (P<0.001). CYP2C9*6 was not found. The frequency of CYP2C9*2 was lower in Amerindians than in European populations, and higher than their Asian ancestors. The presence of this allele in ethnic groups in Mexico can be explained by European admixture.
Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional del IPN Unidad Durango, Academia de Genómica, CIIDIR-IPN, Durango, México.
M
M
Sosa-Macías
B P
BP
Lazalde-Ramos
C
C
Galaviz-Hernández
H
H
Rangel-Villalobos
J
J
Salazar-Flores
V M
VM
Martínez-Sevilla
M L
ML
Martínez-Fierro
P
P
Dorado
M L
ML
Wong
J
J
Licinio
A
A
LLerena
D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D065729:Cytochrome P-450 CYP2C9; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D008800:Mexico; D060888:Real-Time Polymerase Chain Reaction
C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases