Determination of Glucose Concentration in Whole Blood using Fourier-Transform Infrared Spectroscopy.
Fourier-transform infrared(FTIR) transmission spectroscopy has beenused for the determination of glucoseconcentrations in whole blood samples fromtwenty-eight patients. A four-vectorpartial least squares calibration model,using the spectral range 950-1200 cm(-1),yielded a standard error of prediction of0.59 mM for an independent test set. Forblood samples from a single patient, wefound that the glucose concentration wasproportional to the difference between thevalues of the second derivative spectrum at1082 cm(-1) and 1093 cm(-1), suggestingthat these two specific wavelengths can beused for determining glucose concentrationsin blood.
Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge, CB3 0HE UK.
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Shen
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Davies
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Linfield
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Taday
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Arnone
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Elsey
Blood; Fourier transform; glucose; infrared spectroscopy