[Pediatric outcome after selective feticide for 30 complicated monochorionic twin pregnancies].
OBJECTIVE
To describe perinatal and pediatric outcome after selective feticide for complicated monochorionic twin pregnancy.


METHODS
We reviewed all consecutive cases of umbilical cord occlusion performed for complicated monochorionic twin pregnancy over a 16-year period. Pediatric follow-up was based on medical records and updated by phone calls to the parents.


RESULTS
Thirty procedures were performed. Indications were: twin-to-twin transfusion syndrome (TTTS) progressing despite serial amniodrainage (n=12) ; twin reversed arterial perfusion (n=9) ; selective growth restriction (n=5) ; severe discordant structural anomalies (n=4). Mean gestational age at procedure was 21.8±3.1gestational weeks (GW) and 31.8±4.8 GW at birth. Overall survival rate was 87%, i.e. 83%, 100%, 60% and 100% for each indication, respectively. Mean pediatric follow-up was 5years (range: 6months to 15years). Medical charts and parents declared normal development in 88% of surviving children, i.e. 67%, 100%, 100%, and 100% for each indication. Cross-comparison between the four groups revealed that in the TTTS group, gestational age at procedure was more advanced (P=0.01) while delivery was slightly earlier (P=0.1), and pediatric development was poorer (P=0.02).


CONCLUSIONS
Pediatric outcome after selective feticide appeared to be poorer for TTTS progressing despite serial amniodrainage than for other indications.
Pôle GOHR, unité de médecine fœtale, CHU d'Estaing, 1, place Lucie-Aubrac, 63003 Clermont-Ferrand cedex 1, France.
A
A
Delabaere
N
N
Favre
L
L
Velemir
S
S
Bentaoui
K
K
Coste
H
H
Laurichesse-Demas
D
D
Lemery
D
D
Gallot
D002657:Child Development; D004200:Diseases in Twins / Q000628:therapy*; D005260:Female; D005330:Fetofetal Transfusion / Q000628:therapy; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D018607:Pregnancy Reduction, Multifetal / Q000009:adverse effects / Q000379:methods*; D059285:Pregnancy, Twin; D012189:Retrospective Studies; D016896:Treatment Outcome; D014430:Twins, Monozygotic