No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a Tunisian population.
We examined the potential involvement of the polymorphism in intron 8 of the presenilin-1 (PSEN1) gene as a risk factor for Alzheimer disease (AD), both through independent effect and interaction with the apolipoprotein E (APOE) ε4 allele risk, in 85 patients and 90 controls. We found no significant differences in the distribution of PSEN1 genotype and allele frequency between both groups; and post stratification distribution with APOE ε4 allele. Age of onset suggests that this polymorphism influences AD progression.
Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia. achouriafef@yahoo.fr
Afef Achouri
AA
Rassas
Sondess Hadj
SH
Fredj
Hela Mrabet
HM
Khiari
Safa
S
Sahnoun
Amina
A
Bibi
Hajer
H
Siala
Amel
A
Mrabet
Taieb
T
Messaoud
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D053764:Presenilin-1 / Q000235:genetics*; D014416:Tunisia / Q000453:epidemiology
D001057:Apolipoproteins E; D053764:Presenilin-1; D004247:DNA