Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association.
Positron emission tomography (PET) of brain amyloid β is a technology that is becoming more available, but its clinical utility in medical practice requires careful definition. To provide guidance to dementia care practitioners, patients, and caregivers, the Alzheimer's Association and the Society of Nuclear Medicine and Molecular Imaging convened the Amyloid Imaging Taskforce (AIT). The AIT considered a broad range of specific clinical scenarios in which amyloid PET could potentially be used appropriately. Peer-reviewed, published literature was searched to ascertain available evidence relevant to these scenarios, and the AIT developed a consensus of expert opinion. Although empirical evidence of impact on clinical outcomes is not yet available, a set of specific appropriate use criteria (AUC) were agreed on that define the types of patients and clinical circumstances in which amyloid PET could be used. Both appropriate and inappropriate uses were considered and formulated, and are reported and discussed here. Because both dementia care and amyloid PET technology are in active development, these AUC will require periodic reassessment. Future research directions are also outlined, including diagnostic utility and patient-centered outcomes.
Department of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Keith A
KA
Johnson
Satoshi
S
Minoshima
Nicolaas I
NI
Bohnen
Kevin J
KJ
Donohoe
Norman L
NL
Foster
Peter
P
Herscovitch
Jason H
JH
Karlawish
Christopher C
CC
Rowe
Maria C
MC
Carrillo
Dean M
DM
Hartley
Saima
S
Hedrick
Virginia
V
Pappas
William H
WH
Thies
D026683:Advisory Committees; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002250:Carbon Radioisotopes; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000378:metabolism; D019317:Evidence-Based Medicine; D006801:Humans; D009683:Nuclear Medicine; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012955:Societies, Medical
D016229:Amyloid beta-Peptides; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals