Nanotopography effects on astrocyte attachment to nanoporous gold surfaces.
Nanoporous gold, synthesized by a self-assembly process, is a new biomaterial with desirable attributes, including tunable nanotopography, drug delivery potential, electrical conductivity, and compatibility with conventional microfabrication techniques. This study reports on the effect of nanotopography in guiding cellular attachment on nanoporous gold surfaces. While the changes in topography do not affect adherent cell density, average cell area displays a non-monotonic dependence on nanotopography.
Department of Electrical and Computer Engineering at the University of California, Davis, CA 95616, USA. okurtulus@ucdavis.edu
Ozge
O
Kurtulus
Erkin
E
Seker
D000818:Animals; D001253:Astrocytes / Q000166:cytology*; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods; D016503:Drug Delivery Systems; D004553:Electric Conductivity; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000379:methods*; D016062:Porosity; D013696:Temperature
D001672:Biocompatible Materials; D006046:Gold