Protective effects of mangiferin in subchronic developmental lead-exposed rats.
Lead is a ubiquitous environmental and industrial pollutant. Exposure to excessive amounts of lead is especially harmful to the central nervous systems of infants and young children, and oxidative stress has been reported as a major mechanism of lead-induced toxicity. To evaluate the ameliorative potential of antioxidant mangiferin (MGN) on lead-induced toxicity, Morris water maze test, determination of blood and bone lead concentration, determination of antioxidant status in plasma, as well as observation of ultrastructural changes in the hippocampus were carried out. In the present study, under a transmission electron microscope, ameliorated morphological damages in the hippocampus were observed in MGN-treated groups. Blood and bone lead concentration in MGN-treated groups lowered to some extent (p < 0.05, p < 0.01). The activities of antioxidant enzymes, glutathione (GSH) content, and the GSH/oxidized glutathione ratio in MGN-treated groups were increased, respectively. Further studies are needed to establish whether the observed differences were a direct cause of mangiferin on lead-induced toxicity or not. This study might provide clues for the treatment of lead-induced toxicity.
MOE Key Lab of Environment and Health, Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
Hao-Wen
HW
Li
Jia-Gang
JG
Deng
Zheng-Cai
ZC
Du
Mao-Sheng
MS
Yan
Zhi-Xiang
ZX
Long
Phuong-Thao
PT
Pham Thi
Ke-Di
KD
Yang
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D005260:Female; D019803:Glutathione Disulfide / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D007855:Lead Poisoning / Q000188:drug therapy* / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D046529:Microscopy, Electron, Transmission; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D044004:Xanthones / Q000627:therapeutic use*
D000975:Antioxidants; D017382:Reactive Oxygen Species; D044004:Xanthones; C013592:mangiferin; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D019803:Glutathione Disulfide