Association of chromosome 9p21 genetic variants with risk of coronary heart disease in the East Asian population: a meta-analysis.
Our aim was to evaluate the effect of SNPs in the 9p21 locus on genetic susceptibility of coronary heart disease in the East Asian population. We searched PubMed, EMBASE and CNKI for publications relating to the association between SNPs within the 9p21 locus and coronary heart disease in the East Asian population. This meta-analysis was assessed by STATA 9.2. Twenty-one studies from 15 eligible papers composing 25,945 cases and 31,777 control subjects were included in the meta-analysis. The odds ratio (OR) and 95% confidence interval (CI) for the risk allele was 1.30 (1.25-1.35) with moderate heterogeneity. No publication bias was observed in this study. Sensitivity analysis further strengthened the validity of this association. In conclusion, SNPs within the 9p21 locus were strongly associated with the risk of coronary heart disease in the East Asian population with a similar risk OR to the Caucasian population.
Department of Nephrology Puai Hospital Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People's Republic of China.
Liping
L
Dong
Haoran
H
Wang
Dao Wen
DW
Wang
Hu
H
Ding
D044466:Asian People / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003327:Coronary Disease / Q000208:ethnology / Q000235:genetics*; D016208:Databases, Factual; D005202:Asia, Eastern / Q000453:epidemiology; D005787:Gene Frequency; D056726:Genetic Association Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population / Q000379:methods; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012680:Sensitivity and Specificity