Chitosan electrodeposition for microrobotic drug delivery.
A method to functionalize steerable magnetic microdevices through the co-electrodeposition of drug loaded chitosan hydrogels is presented. The characteristics of the polymer matrix have been investigated in terms of fabrication, morphology, drug release and response to different environmental conditions. Modifications of the matrix behavior could be achieved by simple chemical post processing. The system is able to load and deliver 40-80 μg cm(-2) of a model drug (Brilliant Green) in a sustained manner with different profiles. Chitosan allows a pH responsive behavior with faster and more efficient release under slightly acidic conditions as can be present in tumor or inflamed tissue. A prototype of a microrobot functionalized with the hydrogel is presented and proposed for the treatment of posterior eye diseases.
Institute of Robotics and Intelligent Systems, Tannenstrasse 3, ETH Zürich, Zurich, Switzerland.
Stefano
S
Fusco
George
G
Chatzipirpiridis
Kartik M
KM
Sivaraman
Olgaç
O
Ergeneman
Bradley J
BJ
Nelson
Salvador
S
Pané
D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D055664:Electrochemical Techniques; D008855:Microscopy, Electron, Scanning; D012371:Robotics
D048271:Chitosan
chitosan; drug delivery; electrodeposition; microrobotics; smart materials