82Sr purification procedure using Chelex-100 resin.
(82)Rb is a positron-emitting radionuclide widely used in nuclear cardiology. One great advantage is its availability through a generator loaded with (82)Sr. (82)Sr can be produced in a high energy cyclotron by irradiating rubidium chloride target with proton beam. In this paper, we present an extensive study (elution profiles, effect of the elution flow rate) on the use of Chelex-100 resin and ammonia buffer. No significant effect of flow rate was evidenced between 1 and 10mL/min leading us to propose a purification process which can be easily automated.
GIP Arronax, 1 rue Arronax, Saint-Herblain, France. alliot@arronax-nantes.fr
C
C
Alliot
N
N
Audouin
A C
AC
Bonraisin
V
V
Bossé
J
J
Laizé
C
C
Bourdeau
B M
BM
Mokili
N
N
Michel
F
F
Haddad
D002712:Chlorides / Q000528:radiation effects; D002852:Chromatography, Ion Exchange / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D017357:Cyclotrons; D004583:Electrons; D006801:Humans; D011876:Radionuclide Generators / Q000295:instrumentation; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000302:isolation & purification; D012117:Resins, Synthetic; D012413:Rubidium / Q000528:radiation effects; D013326:Strontium Radioisotopes / Q000302:isolation & purification*
D002712:Chlorides; D019275:Radiopharmaceuticals; D012117:Resins, Synthetic; D013326:Strontium Radioisotopes; C024997:Chelex 100; D012413:Rubidium; C032710:rubidium chloride