An olefin isomerization/asymmetric Pictet-Spengler cascade via sequential catalysis of ruthenium alkylidene and chiral phosphoric acid.
Chiral phosphoric acid works together with Hoveyda-Grubbs II catalyst enabling highly efficient synthesis of enantioenriched tetrahydro-β-carboline (up to 95% yield, 90% ee) through an olefin isomerization/Pictet-Spengler cascade reaction via sequential catalysis.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Quan
Q
Cai
Xiao-Wei
XW
Liang
Shou-Guo
SG
Wang
Shu-Li
SL
You
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D000475:Alkenes; D009942:Organometallic Compounds; D010756:Phosphoric Acids; D012428:Ruthenium