Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology.
BACKGROUND
It is unclear whether diabetes mellitus (DM) is an adverse prognostic factor in chronic heart failure (CHF) of ischaemic and non-ischaemic aetiology managed with contemporary evidence-based care.


METHODS
In total, 1091 outpatients with CHF with reduced ejection fraction were prospectively observed for a mean of 960 days. Total and cardiovascular mortality was quantified after accounting for potential confounders.


RESULTS
In total, 25.7% of patients had DM; this group was more likely to have CHF of ischaemic aetiology and was more symptomatic. Patients with DM received comparable medical- and device-based therapies, except for greater doses of loop diuretic. DM was associated with approximately doubled crude and adjusted risk of total and cardiovascular mortality. The association of diabetes with these outcomes in patients with ischaemic and non-ischaemic cardiomyopathies was of similar magnitude.


CONCLUSIONS
In spite of advances in the management of CHF, DM remains a major adverse prognostic feature, irrespective of ischaemic/non-ischaemic aetiology.
Multidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.
Richard M
RM
Cubbon
Brook
B
Adams
Adil
A
Rajwani
Ben N
BN
Mercer
Peysh A
PA
Patel
Guy
G
Gherardi
Christopher P
CP
Gale
Phillip D
PD
Batin
Ramzi
R
Ajjan
Lorraine
L
Kearney
Stephen B
SB
Wheatcroft
Robert J
RJ
Sapsford
Klaus K
KK
Witte
Mark T
MT
Kearney
D000368:Aged; D002908:Chronic Disease; D048909:Diabetes Complications / Q000401:mortality*; D005260:Female; D006333:Heart Failure / Q000209:etiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology* / Q000401:mortality; D011379:Prognosis; D012307:Risk Factors
Chronic heart failure; aetiology; diabetes mellitus; mortality