Successful treatment of a pregnant woman with Philadelphia chromosome-positive acute lymphoblastic leukemia.
The management of acute leukemia during pregnancy is challenging. Delays in treatment for acute leukemia can adversely affect maternal prognosis, but chemotherapy during pregnancy may induce severe adverse effects on the fetus. Here, we report a case of a pregnant woman with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+)ALL) who underwent remission induction therapy and successfully delivered a live infant after chemotherapy. The case is a 36-year-old woman diagnosed with Ph(+)ALL in the 27th week of pregnancy. She underwent remission induction therapy including daunorubicin, vincristine, cyclophosphamide, and prednisolone. Imatinib was not used in the induction therapy. She delivered the infant after one course of chemotherapy. The infant and the patient are both alive now, without any major complications.
Department of Hematology, Yokohama City University Medical Center, Minami-ku Urafune-chou 4-57, Yokohama, Kanagawa, 232-0024, Japan. yuki1234@yokohama-cu.ac.jp
Yuki
Y
Nakajima
Hideyuki
H
Kuwabara
Yukako
Y
Hattori
Rika
R
Ohshima
Rika
R
Sakai
Masakazu
M
Kitagawa
Naoto
N
Tomita
Yoshiaki
Y
Ishigatsubo
Shin
S
Fujisawa
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy / Q000379:methods; D050498:Live Birth; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D012074:Remission Induction; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D003520:Cyclophosphamide; D011239:Prednisolone; D003630:Daunorubicin