Polyamino geranic derivatives as new chemosensitizers to combat antibiotic resistant gram-negative bacteria.
Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate reagent (BOP) serves as an efficient and versatile coupling reagent for the design and synthesis of new polyamino geranic acid derivatives in moderate to good chemical yields varying from 47% to 83%. These compounds induced a significant decrease of antibiotic resistance in two Gram-negative bacterial MDR strains. Our data suggested that their mechanism of action is closely associated with the inhibition of the efflux pumps.
Centre de Recherche en Cancérologie (CRCM), CNRS, UMR7258, Marseille, France. bruneljm@yahoo.fr
Jean Michel
JM
Brunel
Aurélie
A
Lieutaud
Vincent
V
Lome
Jean-Marie
JM
Pagès
Jean-Michel
JM
Bolla
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D014230:Triazoles / Q000737:chemistry
D000900:Anti-Bacterial Agents; D013729:Terpenes; D014230:Triazoles; C012771:benzotriazole; C043081:decaprenoic acid