Prevalence of nonalcoholic steatohepatitis among patients with resectable intrahepatic cholangiocarcinoma.
OBJECTIVE
The objective of this report was to determine the prevalence of underlying nonalcoholic steatohepatitis in resectable intrahepatic cholangiocarcinoma.


METHODS
Demographics, comorbidities, clinicopathologic characteristics, surgical treatments, and outcomes from patients who underwent resection of intrahepatic cholangiocarcinoma at one of eight hepatobiliary centers between 1991 and 2011 were reviewed.


RESULTS
Of 181 patients who underwent resection for intrahepatic cholangiocarcinoma, 31 (17.1 %) had underlying nonalcoholic steatohepatitis. Patients with nonalcoholic steatohepatitis were more likely obese (median body mass index, 30.0 vs. 26.0 kg/m(2), p < 0.001) and had higher rates of diabetes mellitus (38.7 vs. 22.0 %, p = 0.05) and the metabolic syndrome (22.6 vs. 10.0 %, p = 0.05) compared with those without nonalcoholic steatohepatitis. Presence and severity of hepatic steatosis, lobular inflammation, and hepatocyte ballooning were more common among nonalcoholic steatohepatitis patients (all p < 0.001). Macrovascular (35.5 vs. 11.3 %, p = 0.01) and any vascular (48.4 vs. 26.7 %, p = 0.02) tumor invasion were more common among patients with nonalcoholic steatohepatitis. There were no differences in recurrence-free (median, 17.0 versus 19.4 months, p = 0.42) or overall (median, 31.5 versus 36.3 months, p = 0.97) survival after surgical resection between patients with and without nonalcoholic steatohepatitis.


CONCLUSIONS
Nonalcoholic steatohepatitis affects up to 20 % of patients with resectable intrahepatic cholangiocarcinoma.
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Srinevas K
SK
Reddy
Omar
O
Hyder
J Wallis
JW
Marsh
Georgios C
GC
Sotiropoulos
Andreas
A
Paul
Sorin
S
Alexandrescu
Hugo
H
Marques
Carlo
C
Pulitano
Eduardo
E
Barroso
Luca
L
Aldrighetti
David A
DA
Geller
Christine
C
Sempoux
Vlad
V
Herlea
Irinel
I
Popescu
Robert
R
Anders
Laura
L
Rubbia-Brandt
Jean-Francois
JF
Gigot
Giles
G
Mentha
Timothy M
TM
Pawlik
D000368:Aged; D001650:Bile Duct Neoplasms; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000150:complications* / Q000453:epidemiology* / Q000601:surgery; D005234:Fatty Liver / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000453:epidemiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015995:Prevalence