Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa.
We studied the immune response after starting antiretroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/µL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.
Centre for Infectious Disease Epidemiology and Research (CIDER), School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Michael
M
Schomaker
Matthias
M
Egger
Mhairi
M
Maskew
Daniela
D
Garone
Hans
H
Prozesky
Christopher J
CJ
Hoffmann
Andrew
A
Boulle
Lukas
L
Fenner
D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D008297:Male; D013019:South Africa; D014376:Tuberculosis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D019562:Viral Load
D019380:Anti-HIV Agents