[Cyclic phosphatidic acids and their analogues--unique lipid mediators].
Lysophosphatidic acid (1-acyl-2-sn-glycerol-3-phosphate; LPA) and its naturally occurring analog, cyclic phosphatidic acid (1-acyl-sn-glycerol-2,3-cyclic phosphate; cPA) belong to a group of bioactive glycerophospholipids, which attract attention of many scientists because of their biological functions. Among these two compounds LPA is known better; information about unique biological properties of cPA appeared for the first time in the 90's. The synthesis of various, chemically modified analogues of cPA was performed to highlight mechanisms of the compound actions. Both native cPA and its derivatives emerge into the limelight because of their anti-cancer activities. Knowledge about pathways of biosynthesis and biodegradation of LPA and cPA as well as understanding of mechanisms of their action are increasing gradually. Previous studies have shown that both the metabolism and signaling cascades of these compounds have numerous common points. What is even more interesting, LPA and cPA seem to induce opposite biological activities.
Instytut Biochemii Technicznej, Wydział Biotechnologii i Nauk o Zywności, Politechnika Łódzka, Łódź. grzelczyka@gmail.com
Anna
A
Grzelczyk
Maria
M
Koziołkiewicz
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D009474:Neurons / Q000378:metabolism; D010712:Phosphatidic Acids / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D049368:Receptors, Lysophosphatidic Acid / Q000378:metabolism
D000970:Antineoplastic Agents; D010712:Phosphatidic Acids; D049368:Receptors, Lysophosphatidic Acid; D004259:DNA-Directed DNA Polymerase