Elevated homocysteine? Consider testing for folate metabolism gene variants.
Folate metabolism is fundamental to health, as it closely regulates homocysteine level. Recent research suggests there is a genomic basis for individual variation in folate metabolism related to single nucleotide polymorphisms (SNPs). This article describes how two SNPs, both of which are methylenetetrahydrofolate reductase (MTHFR) variants, can affect the way an individual metabolizes folate, resulting in elevated homocysteine level, and why testing for these SNPs may be important.
University of Minnesota Physician's Women's Health Specialists Clinic, USA.
Catherine
C
Bogolub
D000483:Alleles; D005492:Folic Acid / Q000378:metabolism*; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000175:diagnosis / Q000235:genetics*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D005492:Folic Acid; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)