Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk.
OBJECTIVE
To investigate the association between intake of flaxseed-the richest source of dietary lignans (a class of phytoestrogens)-and breast cancer risk.


METHODS
A food frequency questionnaire was used to measure the consumption of flaxseed and flax bread by 2,999 women with breast cancer and 3,370 healthy control women who participated in the Ontario Women's Diet and Health Study (2002-2003). Logistic regression was used to investigate associations between consumption of flaxseed and flax bread and breast cancer risk. Confounding by established and suspected breast cancer risk factors, as well as dietary factors, was assessed.


RESULTS
Flaxseed or flax bread was consumed at least weekly by 21 % of control women. None of the 19 variables assessed were identified as confounders of the associations between flaxseed or flax bread and breast cancer risk. Consumption of flaxseed was associated with a significant reduction in breast cancer risk (odds ratio (OR) = 0.82, 95 % confidence interval (CI) 0.69-0.97), as was consumption of flax bread (OR = 0.77, 95 % CI 0.67-0.89).


CONCLUSIONS
This Canadian study is, to our knowledge, the first to report on the association between flaxseed alone and breast cancer risk and has found that flaxseed intake is associated with a reduction in breast cancer risk. As dietary intake of flaxseed is modifiable, this finding may be of public health importance with respect to breast cancer prevention.
Prevention and Cancer Control, Cancer Care Ontario, 620 University Ave, Toronto, ON, M5G 2L7, Canada. beth.lowcock@cancercare.on.ca
Elizabeth C
EC
Lowcock
Michelle
M
Cotterchio
Beatrice A
BA
Boucher
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000209:etiology / Q000517:prevention & control*; D002170:Canada; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D019597:Flax; D005500:Follow-Up Studies; D006801:Humans; D017705:Lignans / Q000627:therapeutic use*; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors
D017705:Lignans