The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action.
The first structure determination of a neuraminidase inhibitor, oseltamivir phosphate, the active component of the anti-influenza agent Tamiflu, was achieved by single crystal X-ray diffraction with synchrotron radiation. The structure reproduces to a great extent the binding of the inhibitor in the neuraminidase active site and provides more accurate structural parameters as well as detailed insight into the binding preferences of the inhibitor.
New York University Abu Dhabi, PO Box 129188, Abu Dhabi, UAE. pance.naumov@nyu.edu
Panče
P
Naumov
Nobuhiro
N
Yasuda
Wael M
WM
Rabeh
Joel
J
Bernstein
D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D008968:Molecular Conformation; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D053139:Oseltamivir / Q000737:chemistry* / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D053139:Oseltamivir; D009439:Neuraminidase