Intrauterine fetal loss associated with Candida glabrata chorioamnionitis: report of two cases.
Chorioamnionitis is most commonly the result of an ascending infection caused by     bacteria found within the lower genital tract. Yeast infections causing     chorioamnionitis are very uncommon. Candida glabrata is a yeast that is     considered to be a commensal of the vagina but vaginitis and rarely upper     genital tract infection have been described. We report two cases of fungal     chorioamnionitis occurring in pregnancies with a history of in vitro     fertilization and cervical cerclage, both resulting in fetal loss. The     histological features in conjunction with the positive cultures enabled C.     glabrata to be identified as the causative organism producing severe     chorioamnionitis. C. glabrata was probably introduced into the cervix at the     time of embryo transfer, and during stitching the cervix. To prevent unfavorable     outcomes in pregnant women, we recommend that vaginal and in particular cervical     swabs should be taken prior to cervical procedures and appropriate treatment     should be provided.
Department of Pathology, Dokuz Eylül University, Faculty of Medicine,İzmir, Turkey.
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D000328:Adult; D041221:Candida glabrata; D002177:Candidiasis / Q000150:complications*; D002821:Chorioamnionitis / Q000382:microbiology*; D004624:Embryo Transfer / Q000009:adverse effects; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects; D005313:Fetal Death / Q000209:etiology*; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome