Organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position.
We report the first organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position. Importantly, 3-thiooxindoles and 3-alkoxyoxindoles are demonstrated to be reactive nucleophiles for the development of catalytic asymmetric reactions for the first time.
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai, 200062, PR China.
Feng
F
Zhou
Xing-Ping
XP
Zeng
Chao
C
Wang
Xiao-Li
XL
Zhao
Jian
J
Zhou
D000586:Amination; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D008968:Molecular Conformation; D000078183:Oxindoles; D013237:Stereoisomerism
D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D002244:Carbon