Polymeric packaging for fully implantable wireless neural microsensors.
We present polymeric packaging methods used for subcutaneous, fully implantable, broadband, and wireless neurosensors. A new tool for accelerated testing and characterization of biocompatible polymeric packaging materials and processes is described along with specialized test units to simulate our fully implantable neurosensor components, materials and fabrication processes. A brief description of the implantable systems is presented along with their current encapsulation methods based on polydimethylsiloxane (PDMS). Results from in-vivo testing of multiple implanted neurosensors in swine and non-human primates are presented. Finally, a novel augmenting polymer thin film material to complement the currently employed PDMS is introduced. This thin layer coating material is based on the Plasma Enhanced Chemical Vapor Deposition (PECVD) process of Hexamethyldisiloxane (HMDSO) and Oxygen (O(2)).
School of Engineering, Brown University, Providence, RI 02912, USA. Juan_Aceros@brown.edu
Juan
J
Aceros
Ming
M
Yin
David A
DA
Borton
William R
WR
Patterson
Christopher
C
Bull
Arto V
AV
Nurmikko
D000818:Animals; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D055724:Electrophysiological Phenomena; D006801:Humans; D008253:Macaca mulatta; D008422:Materials Testing; D058117:Neural Prostheses; D011474:Prosthesis Design; D058998:Remote Sensing Technology / Q000295:instrumentation; D012833:Siloxanes; D034421:Sus scrofa; D013686:Telemetry / Q000295:instrumentation; D059015:Wireless Technology / Q000295:instrumentation*
D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D012833:Siloxanes; C015917:hexamethyldisiloxane