Reduction of CAII Expression in Gastric Cancer: Correlation with Invasion and Metastasis.
OBJECTIVE
Human carbonic anhydrases II (CAII) gene plays an important role in different cancer. However, its relevance to gastric cancer (GC) remains unclear. In the present study, we aimed to investigate the expression of CAII in GC and explore its correlation with some clinicopathologic characteristics of GC.


METHODS
The expression of CAII in 20 specimens of normal gastric mucosa, 38 specimens of intraepithelial neoplasia and 112 specimens of gastric carcinoma were detected by immunohistochemical techniques. Survival in GC with CAII expression was studied.


RESULTS
The positive rate of CAII protein in normal gastric mucosa was significantly higher than that in intraepithelial neoplasia and gastric carcinoma (100% vs. 63.16% and 28.57%, P<0.001). The positive rate of CAII protein was significantly higher in gastric carcinoma at early stages than that at advanced stages (70.0% vs. 19.57%, P<0.001). The positive rate of CAII protein was significantly lower in gastric carcinoma with lymph node metastases than that without lymph node metastases (10.81% vs. 37.33%, P<0.05). Furthermore, the positive rate of CAII protein was significantly lower in poorly-differentiated gastric carcinoma than in moderately- or well-differentiated gastric carcinoma (15.94% vs. 31.03% or 60.00%, P<0.05). Moreover, CAII expression was not related with sex, age and tumor size. The patients with CAII-positive tumors showed a better survival rate than those with CAII-negative tumors (P=0.024, log-rank test).


CONCLUSIONS
CAII expression was related with stages and lymph node metastases in gastric carcinoma. The reduction of CAII expression in GC might promote tumor cell motility and contribute to tumor growth and metastasis.
Department of Pathology, 1st People's Hospital of Chenzhou, Chenzhou 423000, China ; Institute of Cancer Research, University of South China, Hengyang 421001, China.
Xiao-Jie
XJ
Li
Hai-Long
HL
Xie
San-Ju
SJ
Lei
Hui-Qiu
HQ
Cao
Tian-Yun
TY
Meng
Yu-Lin
YL
Hu
CAII; Gastric Carcinoma; Immunohistochemistry; Invasion; Metastasis