High-risk human papillomaviruses in two different primary tumors in the same patient.
Two cases of patients with high-risk human papillomavirus-related squamous cell carcinomas of the penis are reported. In both patients, a second high-risk human papillomavirus-related squamous cell carcinoma, of the same type (genotype 16), was detected: a carcinoma of the oropharynx 2 years after treatment of the squamous cell carcinomas of the penis in the first patient, and a carcinoma of the esophagus 1 year after the treatment of the squamous cell carcinomas of the penis in the second patient. To the best of our knowledge, this is the first time that multiple human papillomavirus-related tumors in the same patient are reported. It is suggested that a careful clinical investigation is necessary in patients with tumors attributable to high-risk human papillomavirus for the early detection of a possible second neoplasm related to this virus in a different organ.
Laboratory of Genomic Studies, Department of Biology, São Paulo State University (UNESP), Brazil.
Mânlio Tasso
MT
de Oliveira Mota
Jane Lopes
JL
Bonilha
Bruno Miziara
BM
Rosa
José Germano Ferraz
JG
de Arruda
Fernando Augusto
FA
Soares
José
J
Vassallo
Marilia Freitas
MF
Calmon
Paula
P
Rahal
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000821:virology*; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000821:virology*; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000821:virology*; D030361:Papillomavirus Infections / Q000150:complications*; D010412:Penile Neoplasms / Q000175:diagnosis / Q000821:virology*; D018570:Risk Assessment
esophageal cancer; human papillomavirus 16; laryngeal cancer; papillomavirus infections; penile cancer