Perioperative use of an anti-inflammatory drug on tooth sensitivity caused by in-office bleaching: a randomized, triple-blind clinical trial.
OBJECTIVE
The aim of this study was to determine the effect of etoricoxib 60 mg on tooth sensitivity (TS) caused by in-office bleaching.


METHODS
A triple-blind, parallel design, randomized clinical trial was conducted on 30 healthy, young adults who received either a placebo or etoricoxib. The drugs were administered 1 h before the bleaching process and after 24 h. Treatment was performed with 35 % hydrogen peroxide gel. The TS was recorded on three scales: VAS, 0-4, and 0-100. Shade evaluations were performed before and 30 days after bleaching with a visual shade guide and a spectrophotometer. The percentage of patients who reported TS at least once during treatment and the TS intensity were evaluated by Fisher's exact and Mann-Whitney U tests, respectively. Tooth color changes were evaluated by repeated measures ANOVA.


RESULTS
There were no significant differences in the percentage of patients with TS, intensity of TS, and color between the groups.


CONCLUSIONS
The anti-inflammatory medication etoricoxib 60 mg was unable to reduce the presence and intensity of TS. NCT01300780 (protocol No. 17838/2010).
Department of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Av. General Carlos Cavalcanti, 4748, Bloco M, Sala 64, Ponta Grossa, Paraná, 84030-900, Brazil.
Eloisa Andrade
EA
de Paula
Alessandro D
AD
Loguercio
Daniel
D
Fernandes
Stella
S
Kossatz
Alessandra
A
Reis
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D006801:Humans; D010919:Placebos; D014073:Tooth Bleaching / Q000009:adverse effects*; D055815:Young Adult
D000893:Anti-Inflammatory Agents; D010919:Placebos