Clinical manifestations and MRI features of vaginal endodermal sinus tumors in four children.
BACKGROUND
Vaginal endodermal sinus tumor is a rare entity.


OBJECTIVE
The purpose of this study was to report the clinical manifestations and MRI features in a case series.


METHODS
Children with vaginal endodermal sinus tumor admitted to our hospitals between January 2008 and August 2012 were included. MRI was performed in all four children and diffusion-weighted imaging was performed in two children.


RESULTS
Four children, mean age 14 months, were included. All had a history of vaginal bleeding. Serum alpha-fetoprotein was significantly elevated on admission. Relative to muscle, the vaginal masses were uniformly isointense on T1-weighted images, heterogeneously hyperintense on T2-weighted images and heterogeneously enhancing on contrast-enhanced images. The vaginal masses were obviously hyperintense on diffusion-weighted images (b value, 800 s/mm(2)). Extravaginal invasion was observed in three children. Pelvic lymphadenopathy was noted in two children and pulmonary metastasis was found in one child.


CONCLUSIONS
MRI may contribute in the evaluation of vaginal endodermal sinus tumors.
Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yan Jiang Xi Road, Guangzhou, 510120, Guangdong Province, China. liu.qingyu@163.com
Qing-Yu
QY
Liu
Li
L
Huang
Xiao-Feng
XF
Lin
Hai-Gang
HG
Li
Ming
M
Gao
Bi-Ling
BL
Liang
D018240:Endodermal Sinus Tumor / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014621:Vagina / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000473:pathology*