Gut microbiota and metabolic disorders: How prebiotic can work?
Experimental data in animals, but also observational studies in obese patients, suggest that the composition of the gut microbiota differs in obese v. lean individuals, in diabetic v. non-diabetic patients or in patients presenting other diseases associated with obesity or nutritional dysbalance, such as non-alcoholic steatohepatitis. In the present review, we will describe how changes in the gut microbiota composition and/or activity by dietary fibres with prebiotic properties, can modulate host gene expression and metabolism. We will evaluate their potential relevance in the management of obesity and related metabolic disturbances, in view of the experimental data and intervention studies published up to date.
Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Avenue Mounier 73, Box B1.73.11, B-1200 Brussels, Belgium. nathalie.delzenne@uclouvain.be
Nathalie M
NM
Delzenne
Audrey M
AM
Neyrinck
Patrice D
PD
Cani
D000818:Animals; D001069:Appetite Regulation; D003920:Diabetes Mellitus / Q000178:diet therapy / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D005234:Fatty Liver / Q000178:diet therapy / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D005759:Gastroenteritis / Q000209:etiology / Q000517:prevention & control*; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology*; D006801:Humans; D050356:Lipid Metabolism; D008659:Metabolic Diseases / Q000178:diet therapy* / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000178:diet therapy / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D056692:Prebiotics
D056692:Prebiotics