Comparative genomic insights into the biosynthesis and regulation of mycobacterial siderophores.
Iron is essential for nearly all biological events. Siderophores are indispensable for most organisms to obtain iron from iron-limiting milieus. This holds particularly true for pathogens such as the causative agent of tuberculosis - Mycobacterium tuberculosis. The categories of mycobacterial siderophores, their biosynthesis and regulation are summarized here. The siderophore biosynthesis and regulation differences between the pathogenic and non-pathogenic mycobacteria are highlighted from comparative genomic perspective, with an aim to find clues for drug or drug target within siderophore metabolism.
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Enviroment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing, China.
Wu
W
Li
Junli
J
He
Longxiang
L
Xie
Tian
T
Chen
Jianping
J
Xie
D055028:Comparative Genomic Hybridization; D007501:Iron / Q000378:metabolism; D005810:Multigene Family; D009161:Mycobacterium / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D048630:Polyketide Synthases / Q000235:genetics / Q000378:metabolism; D017262:Siderophores / Q000096:biosynthesis*
D017262:Siderophores; D048630:Polyketide Synthases; D007501:Iron