Diabetes mellitus and ovarian cancer risk: a systematic review and meta-analysis of observational studies.
OBJECTIVE
The objective of this study was to evaluate the epidemiologic association between diabetes and risk of ovarian cancer.


METHODS
We searched PubMed, EMBASE, and The Cochrane Library for observational studies on the association between diabetes and ovarian cancer. Cohort studies that reported relative risks (RRs) and case-control studies that showed odds ratios were included in the analysis. Summary RRs with 95% confidence intervals (CIs) were calculated with a random-effects model.


RESULTS
A total of 19 studies from 18 articles (7 case-control studies and 11 cohort studies) met the inclusion criteria. Combining data from all studies, diabetes was associated with an increased risk of ovarian cancer, compared with no diabetes (summary RR of ovarian cancer incidence, 1.17; 95% CI, 1.02-1.33). In cohort and nested case-control studies, patients with diabetes had statistically significant increased risk of ovarian cancer (RR, 1.16; 95% CI, 1.01-1.33), without significant heterogeneity (I = 27; P = 0.172). Among studies that control for age, body mass index, smoking, and alcohol, a prominent association between diabetes and ovarian cancer was found (RR, 1.55; 95% CI, 1.11-2.19).


CONCLUSIONS
This study suggests that women with diabetes have a moderately increased risk of ovarian cancer.
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
Jung-Yun
JY
Lee
Inpyo
I
Jeon
Jae Weon
JW
Kim
Yong-Sang
YS
Song
Jae-Moon
JM
Yoon
Sang Min
SM
Park
D005260:Female; D006801:Humans; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D010051:Ovarian Neoplasms / Q000209:etiology; D012307:Risk Factors