Synthesis of α-alkylated β-ketoesters by alkoxycarbonylation/Michael addition domino reaction.
The palladium-catalyzed alkoxycarbonylation of an α-chloro ketone can be efficiently combined to a Michael addition reaction in a new two-step domino reaction, allowing the synthesis of original highly functionalized α-alkylated β-ketoesters. The scope of the reaction was extended to several α-chloro ketones and Michael acceptors with moderate to very good yields.
Unité de Catalyse et Chimie du Solide, UMR CNRS 8181, Université Lille Nord de France, ENSCL BP 90108, 59652 Villeneuve d'Ascq, France.
Benoit
B
Wahl
Yann
Y
Philipson
Hélène
H
Bonin
André
A
Mortreux
Mathieu
M
Sauthier