The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis.
The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.
Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK. fperezcampo@picr.man.ac.uk
Flor M
FM
Perez-Campo
Guilherme
G
Costa
Michael
M
Lie-a-Ling
Valerie
V
Kouskoff
Georges
G
Lacaud
D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D044127:Epigenesis, Genetic; D006410:Hematopoiesis / Q000235:genetics* / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D051548:Histone Acetyltransferases / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D008957:Models, Genetic; D018448:Models, Immunological; D015534:Trans-Activators
D015534:Trans-Activators; D051548:Histone Acetyltransferases; C108712:KAT6A protein, human