Palmitoylation and the trafficking of peripheral membrane proteins.
Palmitoylation, the attachment of palmitate and other fatty acids on to cysteine residues, is a common post-translational modification of both integral and peripheral membrane proteins. Dynamic palmitoylation controls the intracellular distribution of peripheral membrane proteins by regulating membrane-cytosol exchange and/or by modifying the flux of the proteins through vesicular transport systems.
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK. luke.chamberlain@strath.ac.uk
Luke H
LH
Chamberlain
Kimon
K
Lemonidis
Maria
M
Sanchez-Perez
Martin W
MW
Werno
Oforiwa A
OA
Gorleku
Jennifer
J
Greaves
D002462:Cell Membrane / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D054878:Lipoylation; D008565:Membrane Proteins / Q000378:metabolism*; D019308:Palmitic Acid / Q000378:metabolism*; D021381:Protein Transport; D013347:Subcellular Fractions; D050825:Synaptosomal-Associated Protein 25 / Q000378:metabolism; D018631:ras Proteins / Q000378:metabolism
D008565:Membrane Proteins; D050825:Synaptosomal-Associated Protein 25; D019308:Palmitic Acid; D018631:ras Proteins