New and future resuscitation fluids for trauma patients using hemoglobin and hypertonic saline.
Hemoglobin-based oxygen carriers (HBOC) and hypertonic saline solutions (HSS) are used for resuscitation of trauma patients with hemorrhagic shock. In this review, the clinical application, dosing, administration, and side effects of these solutions are discussed. Although HBOC and HSS are not ideal resuscitation fluids, until rapidly thawed universal donor frozen blood and blood component therapy becomes widely available in North America, these fluids should to be considered immediately after injury and throughout the spectrum of care for patients with hemorrhagic shock, until blood and blood components become available.
Division of Trauma Anesthesiology (Program in Trauma, R Adams Cowley Shock Trauma Center), Department of Anesthesiology, Shock Trauma Anesthesia Organized Research Center (STAR ORC), University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Samuel M
SM
Galvagno
Colin F
CF
Mackenzie
D001802:Blood Substitutes / Q000009:adverse effects / Q000627:therapeutic use*; D005440:Fluid Therapy / Q000379:methods*; D006454:Hemoglobins / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D014947:Wounds and Injuries / Q000628:therapy*
D001802:Blood Substitutes; D006454:Hemoglobins; D012462:Saline Solution, Hypertonic; C096798:HBOC 201