A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35years of the ISRC?
Specific Activity (SA), defined as the amount of radioactivity per unit mass of a compound is arguably one of the most important parameters in radiopharmaceutical development, particularly in quality control of carbon-11 and fluorine-18 labeled compounds. This review article will outline the progression of improvements in SA over the last few decades. The International Symposium of Radiopharmaceutical Chemistry (ISRC/ISRS) abstracts were an excellent source of materials for this review and will be referenced throughout.
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. lapis@mir.wustl.edu
Suzanne E
SE
Lapi
Michael J
MJ
Welch
D003226:Congresses as Topic / Q000266:history*; D003287:Contrast Media / Q000737:chemistry / Q000378:metabolism; D062313:Databases, Pharmaceutical; D049673:History, 20th Century; D049674:History, 21st Century; D057054:Molecular Imaging; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000378:metabolism
D003287:Contrast Media; D019275:Radiopharmaceuticals