Clinical analysis of fulminant type 1 diabetes in China and comparison with a nationwide survey in Japan.
OBJECTIVE
To report 26 cases of fulminant type 1 diabetes found in Guangdong Medical College Futian Hospital and Central South University Second Xiangya Hospital in China and to study the difference between Chinese and Japanese patients.


METHODS
The clinical and biochemical characteristics of 26 patients who had been diagnosed with fulminant type 1 diabetes mellitus in China were analyzed retrospectively and then compared with those characteristics of 161 patients from a nationwide survey in Japan at the time of diagnosis and follow-up 6 months.


RESULTS
The mean values of the characteristics from these two data sets, including fasting and postprandial serum C-peptide concentration, serum sodium and potassium level, positive for GADAb were significantly different (P=0.003, P=0.005, P=0.035, P=0.030, P<0.001, respectively).


CONCLUSIONS
The clinical and biochemical characteristics of Chinese patients did not largely differ from those of Japanese patients. Further studies are needed for some unique characteristics found in our group.
Department of Endocrinology, Affiliated Futian Hospital of Guangdong Medical College, Shennan Zhong Road 3025#, Shenzhen 518033, China. liul2005@hotmail.com
Lan
L
Liu
Jiping
J
Mao
Zeyuan
Z
Lu
Xiaojie
X
Yan
Yiyi
Y
Ye
Fengxiu
F
Jiang
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000706:statistics & numerical data; D002648:Child; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003625:Data Collection; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000453:epidemiology* / Q000208:ethnology / Q000628:therapy; D016883:Diabetic Ketoacidosis / Q000453:epidemiology* / Q000208:ethnology / Q000628:therapy; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D055815:Young Adult