The role of palmitoylation in regulating Ras localization and function.
Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras.
Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Sharon
S
Eisenberg
Alex J
AJ
Laude
Alison J
AJ
Beckett
Craig J
CJ
Mageean
Veronica
V
Aran
Maria
M
Hernandez-Valladares
Yoav I
YI
Henis
Ian A
IA
Prior
D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000378:metabolism; D054878:Lipoylation; D008969:Molecular Sequence Data; D019308:Palmitic Acid / Q000378:metabolism*; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D018631:ras Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D020033:Protein Isoforms; D019308:Palmitic Acid; D018631:ras Proteins