Crystal structure, antibacterial and cytotoxic activities of a new complex of bismuth(III) with sulfapyridine.
A new complex of Bi(III) and sulfapyridine was synthesized and characterized by elemental analysis, atomic absorption spectrometry, conductivity analysis, electrospray ionization mass spectrometry (ESI-MS), infrared spectroscopy, and single crystal X-ray diffraction methods. The antimicrobial and the cytotoxic activities of the compound were investigated. Elemental and conductivity analyses are in accordance to the formulation [BiCl₃(C₁₁H₁₁N₃O₂S)₃]. The structure of the complex reveals a distorted octahedral geometry around the bismuth atom, which is bound to three sulfonamidic nitrogens from sulfapyridine, acting as a monodentate ligand, and to three chloride ions. The presence of the compound in solution was confirmed by ESI-MS studies. The complex is 3 times more potent than the ligand against Salmonella typhimurium, 4 times against Staphylococcus aureus, Shigella dysenteriae, and Shigella sonnei and 8 times more potent against Pseudomonas aeruginosa and Escherichia coli. The compound inhibits the growth of chronic myelogenous leukemia cells with an IC₅₀ value of 44 μM whereas the free ligand has no effect up to 100 μM.
Department of Chemistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte 31270-901, MG, Brazil.
Ivana M
IM
Marzano
Marina S
MS
Franco
Priscila P
PP
Silva
Rodinei
R
Augusti
Geandson C
GC
Santos
Nelson G
NG
Fernandes
Mônica
M
Bucciarelli-Rodriguez
Edmar
E
Chartone-Souza
Elene C
EC
Pereira-Maia
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001729:Bismuth / Q000737:chemistry* / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D006860:Hydrogen Bonding; D020014:K562 Cells; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D013427:Sulfapyridine / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001729:Bismuth; D013427:Sulfapyridine