Complexation of C60 fullerene with aromatic drugs.
The contributions of various physical factors to the energetics of complexation of aromatic drug molecules with C(60)  fullerene are investigated in terms of the calculated magnitudes of equilibrium complexation constants and the components of the net Gibbs free energy. Models of complexation are developed taking into account the polydisperse nature of fullerene solutions in terms of the continuous or discrete (fractal) aggregation of C(60)  molecules. Analysis of the energetics has shown that stabilization of the ligand-fullerene complexes in aqueous solution is mainly determined by intermolecular van der Waals interactions and, to lesser extent, by hydrophobic interactions. The results provide a physicochemical basis for a potentially new biotechnological application of fullerenes as modulators of biological activity of aromatic drugs.
Department of Physics, Sevastopol National Technical University, Sevastopol 99053, Crimea, Ukraine. max_evstigneev@mail.ru
Maxim P
MP
Evstigneev
Anatoly S
AS
Buchelnikov
Dmitry P
DP
Voronin
Yuriy V
YV
Rubin
Leonid F
LF
Belous
Yuriy I
YI
Prylutskyy
Uwe
U
Ritter
D002626:Chemistry, Pharmaceutical; D056831:Coordination Complexes / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry; D037741:Fullerenes / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D008024:Ligands; D008751:Methylene Blue / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D011370:Proflavine / Q000737:chemistry
D056831:Coordination Complexes; D037741:Fullerenes; D006841:Hydrocarbons, Aromatic; D008024:Ligands; D004317:Doxorubicin; D011370:Proflavine; C069837:fullerene C60; D008751:Methylene Blue