Comparing the renal safety of isoosmolar versus low-osmolar contrast medium by renal biomarkers N-acetyl-β-D-glucosaminidase and endothelin.
Iodixanol and iopamidol are commonly used contrast agents in coronary angiography. We evaluated the nephrotoxic effects of both contrast media in relation to renal biomarkers. A total of 38 low-risk patients who underwent coronary angiography were enrolled. Patients were randomized to receive either low-osmolar nonionic monomer or isoosmolar nonionic dimer contrast medium. N-Acetyl-β-d-glucosaminidase (NAG), endothelin, blood urea nitrogen, and urine and serum creatinine (SCr) levels were measured before  the procedure (T0), at 6 hours (T6), and at 1 year after the procedure. Plasma endothelin, urine NAG/creatinine, and SCr were higher; accordingly, the urine creatinine values were lower in both the groups when comparing T0 versus T6. The groups were similar with each other when comparing T0 and T6 values. Both the contrast agents may be safely used at a low volume for coronary angiography in low-risk patients. Endothelin and NAG are sensitive to acute renal changes in function. There is a need for further prospective investigations with more patients.
1Department of Clinical Biochemistry, Afyon Sandıklı State Hospital, Afyon, Turkey.
Tuna
T
Semerci
Serap
S
Cuhadar
Filiz Akyildiz
FA
Akçay
Tugba Kantaroglu
TK
Aydin
Aysenur
A
Atay
Mehmet
M
Köseoglu
Serdar
S
Bayata
D000118:Acetylglucosaminidase / Q000652:urine*; D015415:Biomarkers / Q000097:blood* / Q000652:urine*; D001806:Blood Urea Nitrogen; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood / Q000652:urine; D016232:Endothelins / Q000097:blood; D005260:Female; D006801:Humans; D007479:Iopamidol / Q000009:adverse effects*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D009994:Osmolar Concentration; D011446:Prospective Studies; D014283:Triiodobenzoic Acids / Q000009:adverse effects*
D015415:Biomarkers; D003287:Contrast Media; D016232:Endothelins; D014283:Triiodobenzoic Acids; D003404:Creatinine; D000118:Acetylglucosaminidase; C044834:iodixanol; D007479:Iopamidol
contrast agents; contrast-induced nephropathy; coronary angiography; endothelins