Cancer incidence and survival in adolescents and young adults in France, 2000-2008.
This study aimed to describe cancer incidence (2000-2008) and survival (2000-2004) in France in adolescents and young adults (AYA). All cases of cancer diagnosed in 15-24 years, recorded by all French population-based registries (14% of the French population), over the 2000-2008 period, were included. Incidence change over time was described with the conventional annual percentage change (cAPC). The survival of cases diagnosed (2000-2004) was estimated using Kaplan-Meier method. A total of 1022 in adolescents and 1396 in young adults were diagnosed. Overall incidence rates were 219.4/10(6) in 15-19 year olds and 293.1/10(6) in 20-24 year olds. The most frequently diagnosed cancers in male AYA were malignant gonadal germ-cell tumors and Hodgkin's disease, and were melanoma, thyroid carcinoma, and Hodgkin's disease in females. The age-standardized rates appeared stable over time in AYA, with a cAPC of +2.0% (P = 0.68). The 5-year overall survival for all cancers was different between genders and age groups, with 78.8% (95%CI: 75.6-82.0) for males and 85.2% (95%CI: 82.2-88.1) for females (P = 0.01), and 78.5% (95%CI: 75.0-82.1) in 15-19 year olds and 84.3% (95% CI: 81.6-87.0) in 20-24 year olds (P = 0.02). Noteworthy, the frequency and the distribution of tumor types in AYA are unique and different from the observed at any other age group. Survival in French AYA has improved over time. Epidemiological data might reflect major trends in the risk factors and preventive interventions. Thus, further research into etiology of cancers affecting AYA should become key priorities for cancer control among AYA.
Registre National des Tumeurs Solides de l'Enfant, CHU Nancy, Faculté de Médecine, 9 Avenue de la Forêt de Haye, Vandoeuvre lès-Nancy cedex, France. emmanuel.desandes@medecine.uhp-nancy.fr
Emmanuel
E
Desandes
Brigitte
B
Lacour
Aurélien
A
Belot
Florence
F
Molinie
Patricia
P
Delafosse
Brigitte
B
Tretarre
Michel
M
Velten
Erik-André
EA
Sauleau
Anne-Sophie
AS
Woronoff
Anne-Valérie
AV
Guizard
Olivier
O
Ganry
Simona
S
Bara
Pascale
P
Grosclaude
Xavier
X
Troussard
Véronique
V
Bouvier
Laurence
L
Brugieres
Jacqueline
J
Clavel
D000293:Adolescent; D000328:Adult; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000453:epidemiology* / Q000401:mortality; D013997:Time Factors; D055815:Young Adult