Synthesis of monodisperse hollow carbon nanocapsules by using protective silica shells.
Monodisperse hollow carbon nanocapsules (<200 nm) with mesoporous shells were synthesized by coating their outer shells with silica to prevent aggregation during their high-temperature annealing. Monodispersed silica nanoparticles were used as starting materials and octadecyltrimethoxysilane (C18TMS) was used as a carbon source to create core-shell nanostructures. These core-shell nanoparticles were coated with silica on their outer shell to form a second shell layer. This outer silica shell prevented aggregation during calcination. The samples were characterized by TEM, SEM, dynamic light scattering (DLS), UV/Vis spectroscopy, and by using the Brunauer-Emmett-Teller (BET) method. The as-synthesized hollow carbon nanoparticles exhibited a high surface area (1123 m(2) g(-1)) and formed stable dispersions in water after the pegylation process. The drug-loading and drug-release properties of these hollow carbon nanocapsules were also investigated.
Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742, Republic of Korea.
Bo
B
Quan
Gi-Eun
GE
Nam
Hyuck Jae
HJ
Choi
Yuanzhe
Y
Piao
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000633:toxicity; D002244:Carbon / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D007052:Ibuprofen / Q000737:chemistry / Q000633:toxicity; D053769:Nanocapsules / Q000737:chemistry* / Q000633:toxicity; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D016062:Porosity; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D053769:Nanocapsules; D012821:Silanes; D014867:Water; D011092:Polyethylene Glycols; D002244:Carbon; D012822:Silicon Dioxide; D007052:Ibuprofen