Objective measures of sleep and dim light melatonin onset in adolescents and young adults with delayed sleep phase disorder compared to healthy controls.
Delayed sleep phase disorder is characterized by a delay in the timing of the major sleep period relative to conventional norms. The sleep period itself has traditionally been described as normal. Nevertheless, it is possible that sleep regulatory mechanism disturbances associated with the disorder may affect sleep duration and/or architecture. Polysomnographic data that may shed light on the issue are scarce. Hence, the aim of this study was to examine polysomnographic measures of sleep in adolescents and young adults with delayed sleep phase disorder, and to compare findings to that of healthy controls. A second aim was to estimate dim light melatonin onset as a marker of circadian rhythm and to investigate the phase angle relationship (time interval) between dim light melatonin onset and the sleep period. Data from 54 adolescents and young adults were analysed, 35 diagnosed with delayed sleep phase disorder and 19 healthy controls. Results show delayed timing of sleep in participants with delayed sleep phase disorder, but once sleep was initiated no group differences in sleep parameters were observed. Dim light melatonin onset was delayed in participants with delayed sleep phase disorder, but no difference in phase angle was observed between the groups. In conclusion, both sleep and dim light melatonin onset were delayed in participants with delayed sleep phase disorder. The sleep period appeared to occur at the same circadian phase in both groups, and once sleep was initiated no differences in sleep parameters were observed.
Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway. ingvild.saxvig@isf.uib.no
Ingvild W
IW
Saxvig
Ane
A
Wilhelmsen-Langeland
Ståle
S
Pallesen
Oystein
O
Vedaa
Inger H
IH
Nordhus
Eli
E
Sørensen
Bjørn
B
Bjorvatn
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008550:Melatonin / Q000032:analysis / Q000378:metabolism*; D017286:Polysomnography; D012463:Saliva / Q000737:chemistry / Q000378:metabolism; D012890:Sleep / Q000502:physiology*; D020178:Sleep Disorders, Circadian Rhythm / Q000503:physiopathology*; D013997:Time Factors; D055815:Young Adult
D008550:Melatonin
circadian rhythm; delayed sleep phase disorder; dim light melatonin onset; phase angle; polysomnography; sleep