pH control of the electrostatic binding of gold and iron oxide nanoparticles to tobacco mosaic virus.
We report the binding of nanoparticles (NPs) to wild type (unmodified) tobacco mosaic virus (TMV). The viruses are simply mixed with citrate-coated, negatively charged gold and iron oxide nanoparticles (IONPs) in acidic solution. This results in TMV decorated along its whole length by the respective particles. Such a decoration usually requires chemical modification or mutation of TMV (e.g., cysteine residues), but here we simply reduce TMV's natural negative charge by protonation. The particles are protonated to a much smaller extent. This charge-based mechanism does not operate for neutral particles.
CIC nanoGUNE Consolider, Donostia-San Sebastián, Spain.
Abid A
AA
Khan
Eoin K
EK
Fox
Marcin Ł
MŁ
Górzny
Elizaveta
E
Nikulina
Dermot F
DF
Brougham
Christina
C
Wege
Alexander M
AM
Bittner
D005290:Ferric Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry*; D014027:Tobacco Mosaic Virus
D005290:Ferric Compounds; C000499:ferric oxide; D006046:Gold