The battle between rotavirus and its host for control of the interferon signaling pathway.
Viral pathogens must overcome innate antiviral responses to replicate successfully in the host organism. Some of the mechanisms viruses use to interfere with antiviral responses in the infected cell include preventing detection of viral components, perturbing the function of transcription factors that initiate antiviral responses, and inhibiting downstream signal transduction. RNA viruses with small genomes and limited coding space often express multifunctional proteins that modulate several aspects of the normal host response to infection. One such virus, rotavirus, is an important pediatric pathogen that causes severe gastroenteritis, leading to ~450,000 deaths globally each year. In this review, we discuss the nature of the innate antiviral responses triggered by rotavirus infection and the viral mechanisms for inhibiting these responses.
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Michelle M
MM
Arnold
Adrish
A
Sen
Harry B
HB
Greenberg
John T
JT
Patton
D005759:Gastroenteritis / Q000276:immunology / Q000821:virology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007372:Interferons / Q000276:immunology* / Q000378:metabolism; D012401:Rotavirus / Q000254:growth & development / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology* / Q000821:virology; D015398:Signal Transduction / Q000276:immunology
D007372:Interferons