[The effect of runihol and exogenous S-adenosyl-L-methionine on the morphological pattern of the liver upon hepatotoxic exposure to reserve-series antituberculous drugs].
Experiments on 160 male albino outbred rats investigated the hepatoprotective activity of S-adenosyl-L-methionine (SAM) and runihol in liver damage caused by subtoxic doses of reserve-series antituberculous drugs (ATD) (PASA, cycloserine, prothionamide) and their combination. It was established that a combination of ATDs had the maximum hepatotoxic activity, cycloserine had the least. There was evidence that SAM versus runihol had a more pronounced ability to correct ATD-induced evolving cytolysis syndrome. Histological study indicated that SAM and runihol also showed a marked hepatoprotective effect. When added to PASA, prothionamide, or a combination of ATDs, both drugs promoted recovery of the hepatic architectonics and a reduction in the prevalence of albuminous dystrophy. The use of SAM additionally led to activation of alterative processes in the hepatic parenchyma.
D S
DS
Sukhanov
T I
TI
Vinogradova
N V
NV
Zabolotnykh
S N
SN
Vasil'eva
M L
ML
Vitovskaia
D000814:Aniline Compounds / Q000633:toxicity; D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D003523:Cycloserine / Q000633:toxicity; D004338:Drug Combinations; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008297:Male; D051379:Mice; D011108:Polymers / Q000633:toxicity; D020011:Protective Agents / Q000008:administration & dosage*; D011515:Prothionamide / Q000633:toxicity; D012436:S-Adenosylmethionine / Q000008:administration & dosage*; D013451:Sulfonic Acids / Q000633:toxicity
D000814:Aniline Compounds; D000995:Antitubercular Agents; D004338:Drug Combinations; C526419:Poly(aniline-2-sulfonic acid); D011108:Polymers; D020011:Protective Agents; D013451:Sulfonic Acids; D011515:Prothionamide; D012436:S-Adenosylmethionine; D003523:Cycloserine