Relation of neutrophil to lymphocyte ratio with the presence and severity of stable coronary artery disease.
OBJECTIVE
We examined the association between neutrophil to lymphocyte ratio (NLR) and the complexity of coronary artery disease assessed by SYNTAX score (SS).


METHODS
The study population included patients with chest pain who had undergone coronary angiography for stable angina pectoris. Patients were classified depending on whether the SS was 0 or SS > 0.


RESULTS
Left ventricular ejection fraction, estimated glomerular filtration rate, and NLR were found to be the independent predictors of high SS in multivariate analysis. The area under the receiver-operating curve of NLR was 0.72 (0.65-0.80, P < .001) for predicting high SS. The optimal cutoff value of NLR to predict high SS was 2.7 (sensitivity of 72% and a specificity of 61%). There was a significant correlation between NLR ratio and continuous SS (r = .552, P < .001).


CONCLUSIONS
The NLR is a readily measurable systemic inflammatory marker and is associated with both the presence and the complexity of coronary artery disease.
Department of Cardiology, Ordu University Medical School, Ordu, Turkey drkayaahmet@yahoo.com.
Ahmet
A
Kaya
Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey.
Mustafa
M
Kurt
Department of Cardiology, Ataturk University Medical School, Erzurum, Turkey.
Ibrahim Halil
IH
Tanboga
Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey.
Turgay
T
Işık
Department of Cardiology, Ordu University Medical School, Ordu, Turkey.
Zeki Yüksel
ZY
Günaydın
Internal Medicine, Erzurum Education and Research Hospital, Erzurum, Turkey.
Yasemin
Y
Kaya
Department of Cardiology, Ataturk University Medical School, Erzurum, Turkey.
Selim
S
Topçu
Department of Cardiology, Ataturk University Medical School, Erzurum, Turkey.
Serdar
S
Sevimli
D000368:Aged; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D013318:Stroke Volume
D015415:Biomarkers; D018836:Inflammation Mediators
SYNTAX score; neutrophil/lymphocyte ratio; stable coronary artery disease