Electrical flow metering of blood for point-of-care diagnostics.
We have developed a microfabricated chip that creates a purified white blood cell (WBC) population from whole blood samples and then electrically analyzes the WBCs at the same time as measuring sample volume flown. The flow metering is based on the measurement of the electrical admittance between microelectrodes inside a microfluidic channel. We found that the admittance related to the flow rate linearly. WBC counts which correlated with the flow rate shows how this technique is a viable method in metering and analyzing blood and other biological samples in a point-of-care environment.
Micro and Nanotechnology Laboratory , University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA watkins7@illinois.edu
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N
Watkins
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U
Hassan
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W
Rodriguez
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R
Bashir
D004566:Electrodes; D006801:Humans; D007958:Leukocyte Count; D044085:Microfluidics / Q000295:instrumentation*; D019095:Point-of-Care Systems; D012039:Regional Blood Flow