The activation of the CGRP receptor.
The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.
School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.
James
J
Barwell
Mark
M
Wheatley
Alex C
AC
Conner
Bruck
B
Taddese
Shabana
S
Vohra
Christopher A
CA
Reynolds
David R
DR
Poyner
D018360:Crystallography, X-Ray; D011485:Protein Binding; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000737:chemistry / Q000378:metabolism*
D018015:Receptors, Calcitonin Gene-Related Peptide