A CMOS-based on-chip neural interface device equipped with integrated LED array for optogenetics.
A novel CMOS-based neural interface device equipped with an integrated micro light source array was proposed and demonstrated. Target application of the device is optogenetics. GaInN LED array formed on sapphire substrate was successfully assembled with a multifunctional CMOS image sensor which is capable of injecting current via any of the pixel. We demonstrated addressable LED operation with the present device. The device has advantages such as simultaneous multi-site stimulation and on-chip optical imaging, that are not available with previously reported LED array device for optogenetics.
Graduate School of Materials Science, NaraInstitute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, JAPAN. tokuda@ms.naist.jp
T
T
Tokuda
T
T
Miyatani
Y
Y
Maezawa
T
T
Kobayashi
T
T
Noda
K
K
Sasagawa
J
J
Ohta
D004867:Equipment Design; D019544:Equipment Failure Analysis; D008029:Lighting / Q000295:instrumentation*; D009474:Neurons / Q000502:physiology*; D062308:Optogenetics / Q000295:instrumentation*; D010775:Photic Stimulation / Q000295:instrumentation*; D012666:Semiconductors; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D018511:Systems Integration; D056969:Voltage-Sensitive Dye Imaging / Q000295:instrumentation*