The effect of apricots on the experimental cataract model formed by sodium selenite.
This study was designed in order to investigate whether sun dried apricots have a preventive effect on the experimental cataract model formed by sodium selenite in rats. Fifty-nine Spraque-Dawley rat pups were divided into three groups. Group 1 (control group) consisted of twenty rat pups, born from the rats nourished ad libitum. Group 2 consisted of 18 newborn rats, born from the rats nourished ad libitum with 10% sun dried natural apricots. Group 3 consisted of 21 newborn rats, born from the rats nourished ad libitum. Subcutaneous (30nmol/gr) sodium selenite injection was applied to all the newborn rats except the control group (Group 1) on postpartum day 10. Cataract development was graded by slit-lamp examination and photography. Encapsulated lenses were analyzed for reduced glutathione (GSH) and malondialdehyde (MDA), a marker of lipid per oxidation. Lenses were also analyzed for total nitrite (TN). The presence of oxidative stress in selenite cataract development and its prevention by sun dried apricots.
Inonu University School of Medicine, Department of Ophthalmology, Malatya, Turkey. odoganay@windowslive.com
Selim
S
Doganay
Cem
C
Duz
Penpe Gul
PG
Firat
Cem
C
Cankaya
Derya
D
Kutukde
Yılmaz
Y
Cigremis
D000818:Animals; D000831:Animals, Newborn; D002386:Cataract / Q000139:chemically induced / Q000517:prevention & control*; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017207:Rats, Sprague-Dawley; D018038:Sodium Selenite / Q000633:toxicity*
D008315:Malondialdehyde; D005978:Glutathione; D018038:Sodium Selenite