[Effects of systolic blood pressure and low density lipoprotein on carotid plaques].
OBJECTIVE
To explore the different effects of systolic blood pressure (SBP) and low density lipoprotein on carotid plaques (LDL-C).


METHODS
A total of 101 510 serving and retired workers of a company who participated in the health examination in 2006-2009, 5852 participants were selected as study subjects by stratified random sampling according to the age and sex ratio. These subjects took their health examination in 2010-2011 including the carotid ultrasound. Finally, 5361 eligible participants with complete data were included in the analysis. The detection and weighted rates of carotid plaques were calculated for four groups: normal SBP and LDL-C group (3524 subjects), normal SBP and high LDL-C group (356 subjects), elevated SBP and normal LDL-C group (1308 subjects) and elevated SBP and high LDL-C group (173 subjects). The effects of different baseline SBP and LDL-C on detection rates of the carotid artery plaques were analyzed by logistic regression.


RESULTS
The detection rate of carotid plaques in normal SBP and LDL-C group, normal SBP and high LDL-C group, elevated SBP and normal LDL-C group, elevated SBP and high LDL-C group was 33.7% (1186/3524), 41.3% (147/356), 64.8% (847/1308), 68.8% (119/173) (χ(2) = 425.75, P < 0.05) and the weighted detection rate was 36.0%, 42.0%, 64.5% and 68.3% respectively. For men, the detection rate was 44.2% (877/1985), 51.1% (97/190), 70.6% (657/930), 71.3% (82/115) (χ(2) = 194.02, P < 0.05) and the weighted detection rate was 31.2%, 36.1%, 49.8% and 50.3% respectively. For women, the detection rate was 20.1% (309/1539), 30.1% (50/166), 50.3% (190/378), 63.8% (37/58) (χ(2) = 180.17, P < 0.05) and the weighted detection rate was 30.9%, 46.3%, 70.3%, and 88.1% respectively. After adjusted for other risk factors, the OR (95%CI) value was 1.37 (1.05 - 1.78), 2.05 (1.74 - 2.43) and 2.12 (1.45 - 3.12) for normal SBP and high LDL-C group, elevated SBP and normal LDL-C group and elevated SBP and high LDL-C group respectively compared with normal SBP and LDL-C group.


CONCLUSIONS
Elevated SBP and high LDL-C were risk factors of the carotid artery plaques. Compared with high LDL-C, elevated SBP may add a higher risk for carotid plaques.
Department of Medicine, Linxi Hospital, Affiliated Kailuan General Hospital, Hebei University, Tangshan 063000, China.
Tao
T
Yao
Wen
W
Li
Xiao-Hui
XH
Zhang
Jing
J
Sun
De-Sheng
DS
Wang
Yong-Meng
YM
Zhao
Zhang-Feng
ZF
Wang
Xing-Quan
XQ
Zhao
Shou-Ling
SL
Wu
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D016893:Carotid Stenosis / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D008078:Cholesterol, LDL / Q000097:blood*; D050171:Dyslipidemias; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013599:Systole
D008078:Cholesterol, LDL