Experimental glucose regulation with a high-order sliding-mode controller.
Theoretically High-Order Sliding-Mode Controllers are well suited to perform closed loop glucose regulation because they are insensitive to parameter uncertainties and robust to unknown dynamics that may perturb the system. The implementation of the controller based on the concept of practical relative degree is presented. The controller was tested in Sprague-Dawley rats with steptozotocin induced diabetes. The tests demonstrated high efficacy and robustness of the controller.
Unidad de Investigación en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI (IMSS), México. anagabygh@gmail.com
Ana
A
Gallardo Hernández
Cristina
C
Revilla Monsalve
Leonid
L
Fridman
Ron
R
Leder
Sergio
S
Islas Andrade
Yuri
Y
Shtessel
D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D003198:Computer Simulation; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy*; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D025461:Feedback, Physiological; D005260:Female; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood*; D008954:Models, Biological; D051381:Rats; D013311:Streptozocin; D016896:Treatment Outcome
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D013311:Streptozocin