Bioactive natural products from the antarctic and arctic organisms.
Polar regions are remote and challenging areas on the earth. In view of the unique environment and the severe competition in polar regions, it's considered that the ecological system might be the producer of new compounds with diversity biological activities. This review is an attempt to consolidate the studies about 97 natural products isolated from Antarctic and Arctic organisms including microbes, algae, sponges, bryozoans, and tunicates and so on published in the recent years. The emphasis is mainly about the new compounds, source organisms and biological activities, which signifies the immense competence of Antarctic and Arctic organisms as bioactive natural products producers.
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, No. 800, Xiangyin Rd., Shanghai 200433, People's Republic of China.
Jing-Tang
JT
Liu
Xiao-Ling
XL
Lu
Xiao-Yu
XY
Liu
Yun
Y
Gao
Bo
B
Hu
Bing-Hua
BH
Jiao
Heng
H
Zheng
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry*; D001110:Arctic Regions; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001688:Biological Products; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1