Catalytic asymmetric synthesis of mixed 3,3'-bisindoles and their evaluation as Wnt signaling inhibitors.
TOP class: The first efficient catalytic asymmetric coupling reaction of indoles with isatin-derived nitroalkenes was accomplished by using a complex consisting of a chiral imidazoline aminophenol ligand (1; see scheme) and Cu(OTf)(2). Biological activity of the newly formed chiral 3,3'-bisindoles was also confirmed in a Wnt signaling inhibitory assay.
Department of Chemistry, Graduate School of Science, Chiba University, 1-33 Yayoi, Chiba 263-8522, Japan. tarai@faculty.chiba-u.jp
Takayoshi
T
Arai
Yushi
Y
Yamamoto
Atsuko
A
Awata
Kentaro
K
Kamiya
Masami
M
Ishibashi
Midori A
MA
Arai
D002384:Catalysis; D018360:Crystallography, X-Ray; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D013237:Stereoisomerism; D060449:Wnt Signaling Pathway / Q000187:drug effects*
D007211:Indoles