Energy profile of the space of model protein sequences.
A numerical study of the energy landscape of the space of model proteinsequences is carried out. As a consequence of the heterogeneity of thecontact energies among amino acids, the energy landscape displays a veryrough profile, a behaviour typical of frustrated systems. This givesraise to a hierarchical clustering of low-energy sequences and can have evolutionary consequences.
The Niels Bohr Institute, University of Copenhagen, Bledgamsvej 16, 2100 Copenhagen, Denmark  ; Department of Chemistry, Harvard University, 16 Oxford st., Cambridge, MA USA.
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Tiana
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Broglia
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Shakhnovich
energy landscapes; model protein; space of sequences