Palmitoylation, pathogens and their host.
S-Palmitoylation, the only reversible post-translational lipid modification, confers unique biochemical and functional properties to proteins. Although it has long been known that viral proteins are palmitoylated, recent studies reveal that this modification plays a critical role for pathogens of all kinds and at multiple steps of their life cycle. The present review examines the involvement of S-palmitoylation in infection by viruses, bacteria and parasites and illustrates how pathogens have evolved to manipulate the host palmitoylation machinery.
Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 19, CH-1015 Lausanne, Switzerland. mathieu.blanc@epfl.ch
Mathieu
M
Blanc
Sanja
S
Blaskovic
F Gisou
FG
van der Goot
D018407:Bacterial Physiological Phenomena; D005658:Fungi / Q000502:physiology; D054884:Host-Pathogen Interactions; D054878:Lipoylation; D019308:Palmitic Acid / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism; D018406:Virus Physiological Phenomena
D014764:Viral Proteins; D019308:Palmitic Acid