Regulation of mitochondrial biogenesis and PGC-1α under cellular stress.
Cell function relies on the constant supply of ATP and it is crucial that mitochondrial ATP production adapts to environmental and cellular challenges to maintain cellular function. Key molecules in sensing cellular stress situations seem to be the PGC-family of transcriptional co-activators, which are key regulators of mitochondrial biogenesis. Recent work has identified several stress-regulated pathways that affect mitochondrial biogenesis through modulation of the activity of PGC-1α. This review focuses on caloric restriction, hypoxia as well as the role of reactive oxygen species in regulating mitochondrial biogenesis and how this process is linked to other cellular stress responses.
Institute for Genetics, Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Str. 47A, 50674 Cologne, Germany. tina.wenz@uni-koeln.de
Tina
T
Wenz
D000818:Animals; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D018384:Oxidative Stress; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors / Q000378:metabolism*
D006360:Heat-Shock Proteins; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors