Gold(I)-catalyzed rearrangement of N-aryl 2-alkynylazetidines to pyrrolo[1,2-a]indoles.
Various N-aryl-2-alkynylazetidines were very efficiently converted to pyrrolo[1,2-a]indoles with gold catalysts, especially the 2-biphenyl-dicyclohexylphosphino-gold(I) hexafluoroantimonate, in dichloromethane at room temperature. Additionally, two formal syntheses of bioactive non-natural compounds, i.e. 7-methoxymitosene and an 5-HT(2C) receptor agonist, have been achieved.
Laboratoire de Synthèse, Réactivité Organiques & Catalyse, associé au CNRS, Institut de Chimie, Université de Strasbourg, 4 rue Blaise Pascal, 67070 Strasbourg, France.
Nicolas
N
Kern
Marie
M
Hoffmann
Aurélien
A
Blanc
Jean-Marc
JM
Weibel
Patrick
P
Pale