Antibacterial activity against Porphyromonas gingivalis and biological characteristics of antibacterial stainless steel.
To evaluate the possibility of an alternative to the traditional orthodontic stainless steel implants, the antibacterial activity against Porphyromonas gingivalis (P. gingivalis) and the related cytotoxicity of a type 304 Cu bearing antibacterial stainless steel were studied. The results indicated that the antibacterial stainless steel showed excellent antibacterial property against P. gingivalis, compared with the control steel (a purchased medical grade 304 stainless steel). Compared to the control steel, there were fewer bacteria on the surface of the antibacterial stainless steel, with significant difference in morphology. The cytotoxicities of the antibacterial stainless steel to both MG-63 and KB cells were all grade 1, the same as those of the control steel. There were no significant differences in the apoptosis rates on MG-63 and KB cells between the antibacterial stainless steel and the control steel. This study demonstrates that the antibacterial stainless steel is possible to reduce the incidence of implant-related infections and can be a more suitable material for the micro-implant than the conventional stainless steel in orthodontic treatment.
Department of Orthodontics, School of Stomatology, China Medical University, Shenyang, China.
Dan
D
Zhang
Ling
L
Ren
Yang
Y
Zhang
Nan
N
Xue
Ke
K
Yang
Ming
M
Zhong
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016866:Bacteroidaceae Infections / Q000188:drug therapy / Q000382:microbiology; D001859:Bone Neoplasms / Q000188:drug therapy; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D003301:Copper Radioisotopes / Q000494:pharmacology*; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D008422:Materials Testing; D012516:Osteosarcoma / Q000188:drug therapy*; D016966:Porphyromonas gingivalis / Q000187:drug effects*; D019736:Prostheses and Implants / Q000009:adverse effects*; D016459:Prosthesis-Related Infections / Q000188:drug therapy; D013193:Stainless Steel / Q000737:chemistry / Q000494:pharmacology*; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D003301:Copper Radioisotopes; D013193:Stainless Steel