Oxycodone + naloxone: choose morphine and optimal laxative therapy instead.
At high doses of oxycodone, the fixed-dose combination of oxycodone plus naloxone complicates therapeutic management and will likely have lower analgesic efficacy.
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D003248:Constipation / Q000139:chemically induced / Q000517:prevention & control*; D004338:Drug Combinations; D006801:Humans; D054368:Laxatives / Q000008:administration & dosage / Q000627:therapeutic use*; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009270:Naloxone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010098:Oxycodone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D000701:Analgesics, Opioid; D004338:Drug Combinations; D054368:Laxatives; C557247:oxycodone naloxone combination; D009270:Naloxone; D009020:Morphine; D010098:Oxycodone