Hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage.
OBJECTIVE
To evaluate hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage.


METHODS
Thirty patients with acute intracerebral hemorrhage were enrolled. Transcranial doppler was used to detect variables of bilateral middle cerebral arteria (MCA) including mean velocity (Vm) and pulsitility index (PI) before and after 125 ml and 250 ml mannitol infusion (0, 30, 60, 90, 120, 180, 240 min).


RESULTS
When 125 ml or 250 ml mannitol was infused in patients with acute intracerebral hemorrhage, Vm of bilateral MCA elevated, and reached the top at 30 min, and then decreased. PI decreased in the affected MCA (250 ml) and in the unaffected MCA (125 ml and 250 ml).


CONCLUSIONS
Mannitol infusion in patients with acute intracerebral hemorrhage can improve cerebral blood flow in bilateral hemispheres and decrease intracranial pressure in the hemorrhagic hemisphere (250 ml) and in the nonhemorrhagic hemisphere (125 ml and 250 ml).
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Hong
H
Ye
Yingying
Y
Su
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000628:therapy*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004234:Diuretics, Osmotic / Q000008:administration & dosage* / Q000494:pharmacology; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D008353:Mannitol / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000187:drug effects
D004234:Diuretics, Osmotic; D008353:Mannitol