Some biomarkers in acute myocardial infarction.
BACKGROUND
Several changes in serum biochemical factors occur in acute myocardial infarction (AMI). Recently alterations in serum levels of homocysteine (Hcy), sialic acid (SA) and high sensitive C-reactive protein (HS-CRP) has been attended as risk factors and index for prediction. This study was aimed to show the alterations in these factors and their relationships in AMI.


METHODS
Thirty four patients with AMI were enrolled in this case-control study. Also 51 apparently healthy individuals were selected as control group. Serum was prepared from all subjects in fasting state. Hcy and HS-CRP were measured using ELISA and SA was determined by Erlich method.


RESULTS
Serum levels of Hcy, SA and HS-CRP in AMI patients were 14.35Â±2.55Î¼mol/l, 73.54Â±2.82 mg/dl, and 17.32Â±3.45 mg/l, respectively and in the control group they were 8.31Â±2.66 Î¼mol/l, 59.82Â±2.70 mg/dl and 2.77Â±1.98 mg/l, respectively. Statistical analysis of data showed that serum level of Hcy, SA, and HS-CRP in the patients with AMI was significantly higher than those of control (P < 0.001). Also significant correlation was observed between Hcy-HS-CRP (r= 0.63), SA- Hcy (r= 0.73), and SA - CRP (r= 0.75) (P < 0.05 for all items).


CONCLUSIONS
Our findings showed increased level of HS-CRP, SA, and Hcy in AMI patients. Also obtained data indicated a direct and significant correlation between HS-CRP as an inflammation index and Hcy and SA. Hence these two factors can be used as biomarkers in this disease.
Dept. of Biochemistry, Medical School, Hamadan University of Medical Sciences, Iran.
Am
A
Amiri Majd
M
M
Rezaei
Mt
M
Goodarzi
S
S
Homayoonfar