Intradermal needle-free powdered drug injection by a helium-powered device.
We present a new method for needle-free powdered drug injection via a bench-top gas-powered device. This injector provides an alternative method of vaccine delivery to address the cold chain problem--the cost and risk of transporting temperature sensitive vaccines to developing countries. The device houses interchangeable nozzle inserts to vary orifice geometries and is capable of delivering polymer beads (1-5 µm diameter) into the dermal layer of porcine tissue. Results for injection shape and injection depth versus nozzle orifice diameter demonstrate the device's controllability.
Bioinstrumentation Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. johnhliu@mit.edu
John
J
Liu
N Catherine
NC
Hogan
Ian W
IW
Hunter
D000818:Animals; D011211:Electric Power Supplies; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006371:Helium; D007271:Injections, Intradermal / Q000295:instrumentation*; D007277:Injections, Jet / Q000295:instrumentation*; D009339:Needles; D011208:Powders / Q000008:administration & dosage; D013552:Swine; D014611:Vaccination / Q000295:instrumentation*; D014612:Vaccines / Q000008:administration & dosage*
D011208:Powders; D014612:Vaccines; D006371:Helium