IgM to S-nitrosylated protein is found intrathecally in relapsing-remitting multiple sclerosis.
This study has established the presence of IgM against S-nitrosylated proteins in cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients using S-nitrosocysteine epitope (anti-SNOcys) as previously shown in serum. Anti-SNOcys IgM increased significantly in CSF during relapsing-remitting MS compared to milder neurological conditions. Evidence from albumin, IgG and IgM suggest that the production of anti-SNOcys IgM is intrathecal rather than the result of ingress from serum. Two correlations during relapse: between CSF level of anti-SNOcys IgM and time elapsed since relapse onset; and between CSF and serum anti-SNOcys IgM levels, suggest that this antibody may have potential as a biomarker.
Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
Charlotte
C
Hvaring
Snezana
S
Vujicic
Jan O
JO
Aasly
Douglas L
DL
Feinstein
Linda R
LR
White
Anne I
AI
Boullerne
D000328:Adult; D003545:Cysteine / Q000031:analogs & derivatives* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood / Q000134:cerebrospinal fluid*; D026403:S-Nitrosothiols / Q000276:immunology*; D013223:Statistics as Topic; D055815:Young Adult
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D026403:S-Nitrosothiols; C021315:S-nitrosocysteine; D003545:Cysteine