Fertility in cancer patients after cryopreservation of one ovary.
This questionnaire study describes the fertility and ovarian function in 143 adult female cancer survivors with only one ovary due to cryopreservation of the other. The women were asked about their ovarian function (as defined by the presence of a spontaneous menstrual cycle), pregnancies and their outcome. The mean follow-up time was 58months after cryopreservation (range 24-129months). The risk of premature ovarian failure was high in the group of patients with leukaemia (13/15; 87%) but low in the breast cancer group (5/54; 9%). Fifty-seven women had actively tried to become pregnant after end of treatment; of these, 41 women obtained a total of 68 pregnancies resulting in 45 live births and five ongoing pregnancies, 15 spontaneous abortions, one ectopic pregnancy and two elective abortions. In the remaining 86 women without a pregnancy wish, there had been five elective abortions. Ninety-three per cent of the pregnancies were after natural conception and only four cases were a result of fertility treatment. The overall risk of premature ovarian failure was low (22%). Patients who retain their ovarian function after treatment of a malignant disease have a good chance of becoming pregnant.
The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet 9, DK-2100 Copenhagen, Denmark. kirsten.tryde.schmidt@rh.regionh.dk
K T
KT
Schmidt
A
A
Nyboe Andersen
T
T
Greve
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E
Ernst
A
A
Loft
C
C
Yding Andersen
D001290:Attitude; D001943:Breast Neoplasms / Q000150:complications; D015925:Cryopreservation; D005260:Female; D005298:Fertility; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D007938:Leukemia / Q000150:complications; D009369:Neoplasms / Q000150:complications*; D010053:Ovary / Q000502:physiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D016649:Primary Ovarian Insufficiency / Q000150:complications / Q000453:epidemiology*; D018570:Risk Assessment; D017741:Survivors