Delivery systems and local administration routes for therapeutic siRNA.
With the increasing number of studies proposing new and optimal delivery strategies for the efficacious silencing of gene-related diseases by the local administration of siRNAs, the present review aims to provide a broad overview of the most important and latest developments of non-viral siRNA delivery systems for local administration. Moreover, the main disease targets for the local delivery of siRNA to specific tissues or organs, including the skin, the lung, the eye, the nervous system, the digestive system and the vagina, were explored.
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil.
Fabiana Testa Moura de Carvalho
FT
Vicentini
Lívia Neves
LN
Borgheti-Cardoso
Lívia Vieira
LV
Depieri
Danielle
D
de Macedo Mano
Thais Fedatto
TF
Abelha
Raquel
R
Petrilli
Maria Vitória Lopes Badra
MV
Bentley
D000287:Administration, Topical; D000818:Animals; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000235:genetics / Q000627:therapeutic use*
D034741:RNA, Small Interfering