[Synthesis of novel terpenophenol-chlorin conjugates and evaluation of their membranotropic and membrane protective properties].
A series of terpenophenol-chlorin conjugates where terpenophenolic fragment has amide bond with macrocycle of methylpheophorbide a, formed by amidation of 13(2)-ester group were obtained by interaction of methylpheophorbide a and ortho-aminomethyl derivatives of 2-isobornyl-4-methylphenol. The substances investigated ability to interact with the cell membrane was shown in blood erythrocytes surface structure with scanning electron microscope. The conjugates studied were established to have antioxidant and membrane protective properties resulted from inhibiting H2O2-induced erythrocytes hemolysis and decrease of lipid peroxidation secondary product accumulation.
D V
DV
Belykh
E V
EV
Buravlev
I Iu
IIu
Chukicheva
I S
IS
Tarabukina
O G
OG
Shevchenko
S N
SN
Pliusnina
A V
AV
Kuchin
D000818:Animals; D002734:Chlorophyll / Q000031:analogs & derivatives / Q000737:chemistry; D004910:Erythrocyte Membrane / Q000737:chemistry*; D006461:Hemolysis / Q000187:drug effects*; D006843:Hydrocarbons, Chlorinated / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D051379:Mice; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D006843:Hydrocarbons, Chlorinated; D010636:Phenols; D013729:Terpenes; D002734:Chlorophyll; C032625:methylpheophorbide