[Study on microRNA and Chinese medicine syndromes of coronary artery disease].
MicroRNA (miRNA) is single-stranded small non-coding RNA, which binds to the 3'untranslated region of the target mRNAs and negatively regulates the expression of the target mRNAs by translational inhibition or miRNA cleavage. miRNA plays an important role in regulating the occurrence and progression of coronary artery disease (CAD), and could be potential biomarkers and treatment targets of CAD. The syndrome typing is the superiority and feature for treating CAD by Chinese medicine (CM). To master the space-time qualitation and quantitation is the key step in improving the clinical efficacy of treating CAD. The specificity and sequence of miRNA are very similar to the dynamic space-time features of syndromes. Besides, miRNA is closely correlated with CAD. Therefore, by using miRNA microarray and bioinformatics to build CM syndrome correlated miRNA regulating networks, miRNA can be introduced to study the CM syndromes of CAD, thus providing a new angle to elucidate the essence of CM syndrome of CAD at the post-transcriptional level.
Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing.
Jie
J
Wang
Gui
G
Yu
D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008516:Medicine, Chinese Traditional; D035683:MicroRNAs / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics
D035683:MicroRNAs; D012333:RNA, Messenger