[Herpes zoster after varicella-zoster vaccination].
A five-year-old girl, vaccinated against varicella-zoster virus (VZV) presented with clinical symptoms of herpes zoster in the 6th cervical dermatome. A VZV direct immune-fluorescence assay was negative three times but additional genotypical analysis showed a VZV strain genotype 2 (Oka vaccine strain). Therefore the diagnosis of a breakthrough varicella disease with the vaccine strain was established. An immunodeficiency was ruled out and the patient responded well to the initiated therapy. This case demonstrates that a negative VZV direct immunofluorescence assay does not exclude an infection with the vaccine strain.
HELIOS Klinikum Wuppertal. marion.fahlbusch@helios-kliniken.de
M
M
Fahlbusch
U
U
Wesselmann
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P
Lehmann
D000914:Antibodies, Viral / Q000097:blood; D019433:Chickenpox Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006562:Herpes Zoster / Q000209:etiology* / Q000276:immunology; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000276:immunology; D006801:Humans
D000914:Antibodies, Viral; D019433:Chickenpox Vaccine