[Progress in research on techniques for prolonging half-life of protein and polypeptide drugs].
Following the advancement in molecular biology and recombinant technology, the protein and polypeptide therapeutics have become an important class of clinical drugs due to their unique superiority. However, the problems of stability and short half-life of proteins and peptides also vastly limit their further use in clinic. The focal points of this paper are to introduce the specific ways and the matters needing attention to increase the biological half-life of the therapeutic protein and polypeptide drugs.
Department of Novel Biotechnique for Parasitic Disease Prevention and Control, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China.
Yi
Y
Jin
Chuan-Xin
CX
Yu
D000818:Animals; D004358:Drug Therapy; D006207:Half-Life; D006801:Humans; D010455:Peptides / Q000737:chemistry* / Q000627:therapeutic use; D010600:Pharmacology; D011506:Proteins / Q000737:chemistry* / Q000627:therapeutic use
D010455:Peptides; D011506:Proteins