[Convulsion due to application of low dose meperidine: a case report].
Meperidine is an opiod analgesic used in a variety of clinical situations. The active metabolite, normeperidine, is a central nervous system excitatory agent and has the ability to cause irritability, hyperreflexia, tremor, myoclonus and seizures. Previously identified risk factors for the development of meperidine-related seizures include renal failure, high meperidine dosages, and co-adminestration of hepatic enzyme inducing medications or phenothiazines which decreases seizure treshold. Patients with normal renal function rarely manifest seizure activity when given meperidine. Here we report a 10 year old boy with a femur fraction who had normal renal function. We used low dose meperidine due to post operative pains.
Department of Pediatrics, GATA Haydarpaşa Teaching Hospital, İstanbul, Turkey.
Halit
H
Ozkaya
Abdullah Barış
AB
Akcan
Gökhan
G
Aydemir
Mert
M
Akbaş
D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D003937:Diagnosis, Differential; D005264:Femoral Fractures / Q000601:surgery*; D006801:Humans; D008297:Male; D008614:Meperidine / Q000008:administration & dosage* / Q000009:adverse effects; D010149:Postoperative Pain / Q000517:prevention & control*; D012640:Seizures / Q000139:chemically induced*
D000701:Analgesics, Opioid; D008614:Meperidine