Catalyst-free intramolecular formal carbon insertion into σ-C-C bonds: a new approach toward phenanthrols and naphthols.
The different reactivity of two kinds of carbonyl groups in keto aldehyde substrates has been exploited for the synthesis of phenanthrols, naphthols, and their heteroatom-containing analogues. Key to this highly efficient and robust methodology is the catalyst-free intramolecular formal diazo carbon insertion of N-tosylhydrazones into keto C-C bonds.
Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
Ying
Y
Xia
Peiyuan
P
Qu
Zhenxing
Z
Liu
Rui
R
Ge
Qing
Q
Xiao
Yan
Y
Zhang
Jianbo
J
Wang