Orthogonal synthesis of a heterodimeric ligand for the development of the Gd(III)-Ga(III) ditopic complex as a potential pH-sensitive MRI/PET probe.
A heterodimeric polyaminocarboxylate ligand based on a DO3A-sulfonamide linked to AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetracarboxylic acid) was synthesised via an orthogonal pathway in order to differentiate the two chelating cages and allow the formation of a Gd(III)-Ga(III) heteroditopic complex. The goal is to create a smart MRI/PET probe with pH dependent relaxivity and with the bimodal imaging approach that enables direct quantification of the stimulus, in this case pH. A (1)H NMR relaxometric study of the Gd-Ga heteroditopic complex addressed the pH modulation of the relaxivity and thus its possible use as an MRI pH sensitive probe.
Dipartimento di Scienze e Innovazione Tecnologica, Università degli Studi del Piemonte Orientale Amedeo Avogadro, Viale T. Michel 11, I-15121 Alessandria, Italy.
Nikolay
N
Vologdin
Gabriele A
GA
Rolla
Mauro
M
Botta
Lorenzo
L
Tei
D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry; D019281:Dimerization; D005682:Gadolinium / Q000737:chemistry; D005708:Gallium / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D008279:Magnetic Resonance Imaging; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D049268:Positron-Emission Tomography
D003287:Contrast Media; D008024:Ligands; D015335:Molecular Probes; D009942:Organometallic Compounds; D005682:Gadolinium; D005708:Gallium