[New insights in the pathogenesis and treatment of rosacea].
The production of cathelicidin, an antimicrobial peptide is strongly increased in rosacea. Cathelicidin activates innate immunity, inflammation and angiogenesis. Cutaneous proteases produce inflammatory fragments of cathelicidin. UV-B irradiation and microbial components increase vitamin D3 and TLR2 expression in keratinocytes leading to an increase of cathelicidin production. Retinoids and doxycycline inhibit inflammation, proteases, angiogenesis and TLR2 expression. A multicenter study 2010 proved that isotretinoin with a dose of 0,3 mg/kg/d for 12 weeks and doxycycline with the dose of 100 mg/d for 14 days followed with 50 mg/d were equally effective. Doxycycline 40 mg/d is also effective in milder cases.
OYS, ihotautien klinikka.
Riitta
R
Palatsi
Hanna-Leena
HL
Kelhälä
Päivi
P
Hägg
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D002762:Cholecalciferol / Q000378:metabolism; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000627:therapeutic use*; D015603:Keratinocytes / Q000378:metabolism; D015337:Multicenter Studies as Topic; D012393:Rosacea / Q000188:drug therapy* / Q000378:metabolism*; D051195:Toll-Like Receptor 2 / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects; D054804:Cathelicidins
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D003879:Dermatologic Agents; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2; D002762:Cholecalciferol; D015474:Isotretinoin; D004318:Doxycycline; D054804:Cathelicidins