Regulatory T-cells in chronic lymphocytic leukemia: actor or innocent bystander?
Regulatory T (Treg) cells are now under extensive investigation in chronic lymphocytic leukemia (CLL). This small subset of T-cells has been, in fact, considered to be involved in the pathogenesis and progression of CLL. However, whether Treg dysregulation in CLL plays a key role or it rather represents a simple epiphenomenon is still matter of debate. In the former case, Treg cells could be appealing for targeting therapies. Finally, Treg cells have also been proposed as a prognostic indicator of the disease clinical course.
Onco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata Rionero in Vulture, Italy.
Giovanni
G
D'Arena
Vittorio
V
Simeon
Fiorella
F
D'Auria
Teodora
T
Statuto
Paola Di
PD
Sanzo
Laura De
LD
Martino
Aurelio
A
Marandino
Michele
M
Sangiorgio
Pellegrino
P
Musto
Vincenzo De
VD
Feo
Tregs; chronic lymphocytic leukemia; prognosis