Association study between  Y-chromosome haplogroups and susceptibility to spermatogenic impairment in Han  People from southwest China.
The  non-recombining portion of the Y-chromosome contains numerous polymorphisms;  therefore, it is now the most informative haplotyping system with wide-ranging  applications. Idiopathic azoospermia and oligospermia are among the most  important causes of male infertility. Different haplogroups may have different  genetic backgrounds, which may be either susceptible or unsusceptible to  idiopathic azoospermia or oligospermia. This study investigated the possible  association between Y-chromosome haplogroup distribution and susceptibility to  spermatogenic impairment. Peripheral blood was collected from 193 men with  normozoospermia, 193 men with idiopathic azoospermia and 105 men with  idiopathic oligospermia. All of the subjects underwent karyotyping, azoospermia  factor (AZF) deletion analysis by 15 AZF-specific sequence-tagged  sites and Y-chromosome haplotype analysis by 17 binary markers. Excluding men  with AZF deletions and abnormal karyotypes, the remainder of these 3  groups was named Group i, Group ii, and Group iii, respectively. The  comparisons of 17 Y-haplogroup distributions between Group i and Group ii,  Group iii or Group ii + iii were performed with the SPSS V.18.0 software.  Significantly different Y-haplogroup distributions were observed between Group  i and Group ii in N1* (P = 0.002), between Group i and Group iii in F*, K*, P*,  and O3* (P = 0.002, 0.001, 0.004, and 0.007, respectively), and between Group i  and Group ii + iii in K*, N1* and O3* (P = 0.008, 0.012, and 0.009,  respectively). These results suggest that Y-chromosome haplogroups play a role  in spermatogenic impairment.
Institute of Medical Genetics, Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, School of Life Sciences, Sichuan University, Chengdu, PR China.
J
J
Ran
T T
TT
Han
X P
XP
Ding
X
X
Wei
L Y
LY
Zhang
Y P
YP
Zhang
T J
TJ
Li
S S
SS
Nie
L
L
Chen
D044466:Asian People / Q000235:genetics*; D053713:Azoospermia / Q000235:genetics*; D002681:China; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping / Q000379:methods; D008297:Male; D009845:Oligospermia / Q000235:genetics; D013091:Spermatogenesis / Q000235:genetics*