[The Drosophila midgut as a model to study adult stem cells].
Constant renewal of cells occurs in most tissues throughout the adult lifetime and is insured by the activity of resident stem cells. Recent work has demonstrated the presence of adult stem cells in the Drosophila intestine and consequently, the Drosophila intestine has become a powerful model to understand adult stem cells in vivo. In this review, we summarize our current understanding of the mechanisms controlling cell fate decisions of the intestinal stem cells with a particular focus on the role of the Notch pathway in this process. We also summarize what is known about proliferation control of the intestinal stem cells, which is crucial to maintain tissue homeostasis during normal and environmentally stressful conditions.
Génétique et biologie du développement, Institut Curie, UMR 3215 CNRS, Inserm U934, 26, rue d'Ulm, 75248 Paris Cedex 05, France.
Mahéva
M
Andriatsilavo
Louis
L
Gervais
Clara
C
Fons
Allison J
AJ
Bardin
D053687:Adult Stem Cells; D000818:Animals; D049109:Cell Proliferation; D004331:Drosophila melanogaster / Q000166:cytology*; D006706:Homeostasis; D007422:Intestines / Q000166:cytology; D023421:Models, Animal; D051880:Receptors, Notch
D051880:Receptors, Notch