Prosthetic valve endocarditis caused by Propionibacterium species successfully treated with coadministered rifampin: report of two cases.
We describe two cases of prosthetic valve endocarditis caused by Propionibacterium spp. successfully treated with a combination of rifampin and intravenous penicillin. Rifampin was chosen due to its promising activity against planktonic and biofilm Propionibacterium, its favourable minimal inhibitory concentrations, its excellent oral bioavailability and tissue penetration.
Divison of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. dominique.braun@usz.ch
Dominique Laurent
DL
Braun
Barbara Katharina
BK
Hasse
Julia
J
Stricker
Jan Sven
JS
Fehr
D000193:Actinomycetales Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001021:Aortic Valve / Q000382:microbiology; D001705:Bioprosthesis / Q000009:adverse effects* / Q000382:microbiology; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000627:therapeutic use; D011424:Propionibacterium; D012293:Rifampin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D010406:Penicillins; D012293:Rifampin