Macrolide- and rifampin-resistant Rhodococcus equi on a horse breeding farm, Kentucky, USA.
Macrolide and rifampin resistance developed on a horse breeding farm after widespread use was instituted for treatment of subclinical pulmonary lesions in foals. Resistance occurred in 6 (24%) of 25 pretreatment and 8 (62%) of 13 (62%) posttreatment isolates from affected foals. Drug-resistant isolates formed 2 distinct genotypic clusters.
University of Georgia, Athens, Georgia 30602, USA.
Alexandra J
AJ
Burton
Steeve
S
Giguère
Tracy L
TL
Sturgill
Londa J
LJ
Berghaus
Nathan M
NM
Slovis
Jeremy L
JL
Whitman
Court
C
Levering
Kyle R
KR
Kuskie
Noah D
ND
Cohen
D000193:Actinomycetales Infections / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D000818:Animals; D058345:Asymptomatic Infections; D001947:Breeding; D024901:Drug Resistance, Multiple, Bacterial; D005798:Genes, Bacterial; D006734:Horse Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*; D006736:Horses; D007629:Kentucky; D018942:Macrolides / Q000494:pharmacology*; D058889:Molecular Typing; D010802:Phylogeny; D018410:Pneumonia, Bacterial / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000662:veterinary*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D016929:Rhodococcus equi / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D012293:Rifampin / Q000494:pharmacology*; D014463:Ultrasonography
D018942:Macrolides; D012293:Rifampin