Rhodium-catalyzed chemo- and regioselective cross-dimerization of two terminal alkynes.
Cross-dimerization of terminal arylacetylenes and terminal propargylic alcohols/amides has been achieved in the presence of a rhodium catalyst. This method features high chemo- and regioselectivities rendering convenient and atom economical access to functionalized enynes.
Shanghai Engineering Research Centre of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, 200062, China. huadongxu@gmail.com
Hua-Dong
HD
Xu
Ren-Wei
RW
Zhang
Xiaoxun
X
Li
Suyu
S
Huang
Weiping
W
Tang
Wen-Hao
WH
Hu
D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D019281:Dimerization; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D000577:Amides; D020005:Propanols; D012238:Rhodium; C028255:propargyl alcohol