Animal models of human granulocyte diseases.
In vivo animal models have proven very useful to the understanding of basic biologic pathways of the immune system, a prerequisite for the development of innovate therapies. This article addresses currently available models for defined human monogenetic defects of neutrophil granulocytes, including murine, zebrafish, and larger mammalian species. Strengths and weaknesses of each system are summarized, and clinical investigators may thus be inspired to develop further lines of research to improve diagnosis and therapy by use of the appropriate animal model system.
Computational Biology Branch, National Center for Biotechnology Information, National Institutes of Health, Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894, USA. schaffer@helix.nih.gov
Alejandro A
AA
Schäffer
Christoph
C
Klein
D000818:Animals; D002417:Cattle; D000080984:Congenital Bone Marrow Failure Syndromes; D004195:Disease Models, Animal; D004285:Dogs; D006105:Granulomatous Disease, Chronic; D006801:Humans; D007960:Leukocyte Disorders / Q000145:classification / Q000209:etiology; D018370:Leukocyte-Adhesion Deficiency Syndrome; D051379:Mice; D009503:Neutropenia / Q000151:congenital; D015027:Zebrafish