Clinical application of anti-Müllerian hormone as a predictor of controlled ovarian hyperstimulation outcome.
OBJECTIVE
In 2009 anti-Müllerian hormone (AMH) assay was approved for clinical use in Korea. This study was performed to determine the reference values of AMH for predicting ovarian response to controlled ovarian hyperstimulation (COH) using the clinical assay data.


METHODS
One hundred sixty-two women who underwent COH cycles were included in this study. We collected data on age, basal AMH and FSH levels, total dose of gonadotropins, stimulation duration, and numbers of oocytes retrieved and fertilized. Blood samples were obtained on cycle day 3 before gonadotropin administration started. Serum AMH levels were measured at a centralized clinical laboratory center. The correlation between the AMH level and COH outcomes and cut-off values for poor and high response after COH was analyzed.


RESULTS
Concentration of AMH was significantly correlated with the number of oocytes retrieved (OPU; r=0.700, p<0.001). The mean±SE serum AMH levels for poor (OPU≤3), normal (4≤OPU≤19), and high (OPU≥20) response were 0.94±0.15 ng/mL, 2.79±0.21 ng/mL, and 6.94±0.90 ng/mL, respectively. The cut-off level, sensitivity and specificity for poor and high response were 1.08 ng/mL, 85.8%, and 78.6%; and 3.57 ng/mL, 94.4%, and 83.3%, respectively.


CONCLUSIONS
Our data present clinical reference values of the serum AMH level for ovarian response in Korean women. The serum AMH level could be a clinically useful predictor of ovarian response to COH.
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Jae Eun
JE
Lee
Jung Ryeol
JR
Lee
Byung Chul
BC
Jee
Chang Suk
CS
Suh
Ki Chul
KC
Kim
Won Don
WD
Lee
Seok Hyun
SH
Kim
Anti-Müllerian hormone; Controlled ovarian hyperstimulation; Outcome predictor; Ovarian response