Palladium/norbornene catalytic system: chelation as a tool to control regioselectivity of Pd(IV) reductive elimination.
Palladium/norbornene joint catalysis gives rise to a unique system in which the three most common formal oxidation states of the metal are at work in the same cycle (0, II, and IV). This paper summarizes a selection of synthetic applications and the feasibility of Pd(IV) formation by oxidative addition of aryl halides. On this intermediate, the presence of a suitable chelating group could trigger unexpected aryl-norbornyl coupling, further broadening the scope of readily available polycyclic frameworks.
Institut de Chimie de Substances Naturelles, ICSN/CNRS (UPR 2301), 1 Av de la Terrasse, Bat. 27, 91198 Gif/Yvette, France. max.malacria@upmc.fr
Max
M
Malacria
Giovanni
G
Maestri