Alterations of regional spontaneous neuronal activity and corresponding brain circuit changes during resting state in migraine without aura.
Although previous resting-state studies have reported abnormal functional cerebral changes in patients with migraine without aura (MwoA), few have focused on alterations in both regional spontaneous neuronal activity and corresponding brain circuits in MwoA patients during rest. Eighteen MwoA patients and 18 age- and gender-matched healthy controls (HC) were recruited in the current study. Baseline cerebral alterations were investigated using amplitude of low-frequency fluctuation (ALFF) and region of interest (ROI)-based functional connectivity (FC) analyses. Compared with HC, MwoA patients showed decreased ALFF values in the left rostral anterior cingulate cortex (rACC) and bilateral prefrontal cortex (PFC) as well as increased ALFF values in the right thalamus. FC analysis also revealed abnormal FCs associated with these ROIs. In addition, ALFF values of the left rACC correlated with duration of disease in MwoA. Our findings could lead to a better understanding of intrinsic functional architecture of baseline brain activity in MwoA, providing both regional and brain circuit spontaneous neuronal activity properties.
Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.
Ting
T
Xue
Kai
K
Yuan
Ping
P
Cheng
Ling
L
Zhao
Limei
L
Zhao
Dahua
D
Yu
Tao
T
Dong
Karen M
KM
von Deneen
Qiyong
Q
Gong
Wei
W
Qin
Jie
J
Tian
D000328:Adult; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008297:Male; D020326:Migraine without Aura / Q000503:physiopathology*; D009415:Nerve Net / Q000503:physiopathology*; D009474:Neurons / Q000473:pathology*; D017397:Prefrontal Cortex / Q000503:physiopathology; D012146:Rest / Q000502:physiology*
amplitude of low-frequency fluctuation (ALFF); functional connectivity (FC); functional magnetic resonance imaging (fMRI); migraine without aura (MwoA); resting state