Facile synthesis of 2-arylphenols via palladium-catalyzed cross-coupling of aryl iodides with 6-diazo-2-cyclohexenones.
2-Arylphenols were conveniently synthesized from aryl iodides and 6-diazo-2-cyclohexenones, in moderate to excellent yields, via tandem Pd-catalyzed cross-coupling/aromatization. The preliminary results for the corresponding enantioselective version showed that the coupling products could be generated in up to 72% ee.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
Ke
K
Yang
Jun
J
Zhang
Yun
Y
Li
Bin
B
Cheng
Liang
L
Zhao
Hongbin
H
Zhai
D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003512:Cyclohexanones / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry
D001391:Azo Compounds; D003512:Cyclohexanones; D006847:Hydrocarbons, Iodinated; D010636:Phenols; D010165:Palladium