Epidemiological risk factors in microscopic colitis:  a prospective case-control study.
BACKGROUND
The cause of collagenous colitis (CC) and lymphocytic colitis (LC) is unknown and epidemiological risk factors for CC and LC are not well studied. The aim was to evaluate in a case-control study epidemiological risk factors for CC and LC.


METHODS
In all, 120 patients with CC, 70 with CL, and 128 controls were included. For all cases and controls information was prospectively recorded. A binary logistic regression analysis was performed separately for CC and LC.


RESULTS
Independent associations observed with the diagnosis of CC were: current smoking (odds ratio [OR], 2.4), history of polyarthritis (OR, 20.8), and consumption of lansoprazole (OR, 6.4), low-dose aspirin (OR, 3.8), beta-blockers (OR, 3.6), and angiotensin II receptor antagonists (OR 0.20). In the case of LC they were: current smoking (OR, 3.8), associated autoimmune diseases (OR, 8), and consumption of sertraline (OR, 17.5), omeprazole (OR 2.7), low-dose aspirin (OR, 4.7), and oral antidiabetic drugs (OR, 0.14).


CONCLUSIONS
The consumption of drugs, current smoking, and associated autoimmune diseases were independently associated with the risk of microscopic colitis.
Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Spain. ffbanares@mutuaterrassa.es
Fernando
F
Fernández-Bañares
Monia R
MR
de Sousa
Antonio
A
Salas
Belén
B
Beltrán
Marta
M
Piqueras
Eva
E
Iglesias
Javier P
JP
Gisbert
Beatriz
B
Lobo
Valentí
V
Puig-Diví
Esther
E
García-Planella
Ingrid
I
Ordás
Montserrat
M
Andreu
Marta
M
Calvo
Miguel
M
Montoro
Maria
M
Esteve
Josep M
JM
Viver
D016022:Case-Control Studies; D046729:Colitis, Collagenous / Q000453:epidemiology / Q000209:etiology*; D046730:Colitis, Lymphocytic / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology