Potential antiosteoporotic agents from plants: a comprehensive review.
Osteoporosis is a major health hazard and is a disease of old age; it is a silent epidemic affecting more than 200 million people worldwide in recent years. Based on a large number of chemical and pharmacological research many plants and their compounds have been shown to possess antiosteoporosis activity. This paper reviews the medicinal plants displaying antiosteoporosis properties including their origin, active constituents, and pharmacological data. The plants reported here are the ones which are commonly used in traditional medical systems and have demonstrated clinical effectiveness against osteoporosis. Although many plants have the potential to prevent and treat osteoporosis, so far, only a fraction of these plants have been thoroughly investigated for their physiological and pharmacological properties including their mechanism of action. An attempt should be made to highlight plant species with possible antiosteoporosis properties and they should be investigated further to help with future drug development for treating this disease.
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Min
M
Jia
Yan
Y
Nie
Da-Peng
DP
Cao
Yun-Yun
YY
Xue
Jie-Si
JS
Wang
Lu
L
Zhao
Khalid
K
Rahman
Qiao-Yan
QY
Zhang
Lu-Ping
LP
Qin