Psychosocial variables are related to future exacerbation risk and perinatal outcomes in pregnant women with asthma.
OBJECTIVE
To determine the relationship between psychosocial variables, future exacerbation risk during pregnancy, and perinatal outcomes.


METHODS
A secondary analysis of a randomized controlled trial of exhaled nitric oxide versus guideline-based treatment adjustment in pregnant women with asthma. Women were recruited between 12 and 20 weeks gestation and monitored for the remainder of the pregnancy. Psychosocial questionnaires including the Perceived Control of Asthma Questionnaire, the Brief Illness Perception Questionnaire, and the Six-Item Short-Form State Trait Anxiety Inventory were assessed at randomization. Exacerbations were defined as hospitalization, emergency visit, unscheduled doctor visit, or oral corticosteroid use for worsening asthma. Perinatal outcomes included preterm birth, small for gestational age, and cesarean section. Multiple logistic regressions were performed with predictor variables, including demographics and psychosocial and clinical variables.


RESULTS
The 175 participants had a mean (SD) age = 28.5(5.4) years, forced expiratory volume in 1 second (FEV(1)%) predicted = 95.9(13.4), and asthma control score = 0.88(0.70). Greater perceived control of asthma reduced the odds of subsequent exacerbation (odds ratio (OR) [95%CI] 0.92 [0.85, 0.98], p = .016), cesarean without labor (0.84 [0.75, 0.94], p = .003), and preterm birth (0.84 [0.72, 0.97], p = .019), while increased anxiety increased the odds of subsequent exacerbation (1.05 [1.01, 1.08], p = .008).


CONCLUSIONS
Women's perceptions of asthma control and their psychosocial state (anxiety) are related to future exacerbation risk, cesarean section, and preterm birth.
Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, Newcastle, NSW, Australia. heather.powell@hnehealth.nsw.gov.au
Heather
H
Powell
Kirsten
K
McCaffery
Vanessa E
VE
Murphy
Michael J
MJ
Hensley
Vicki L
VL
Clifton
Warwick
W
Giles
Peter G
PG
Gibson
D000328:Adult; D001249:Asthma / Q000276:immunology* / Q000378:metabolism / Q000523:psychology* / Q000628:therapy; D002585:Cesarean Section / Q000523:psychology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000276:immunology / Q000523:psychology; D016015:Logistic Models; D009569:Nitric Oxide / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology* / Q000378:metabolism / Q000523:psychology* / Q000628:therapy; D047928:Premature Birth / Q000276:immunology / Q000523:psychology; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology; D012129:Respiratory Function Tests; D011795:Surveys and Questionnaires
D009569:Nitric Oxide