Synthesis of antioxidants for prevention of age-related macular degeneration.
Photooxidation of A2E may be involved in diseases of the macula, and antioxidants could serve as therapeutic agents for these diseases. Inhibitors of A2E photooxidation were prepared by Mannich reaction of the antioxidant quercetin. These compounds contain water-solubilizing amine groups, and several were more potent inhibitors of A2E photooxidation than quercetin.
Department of Chemistry, Columbia University, 3000 Broadway, New York, New York 10027, USA.
Dharati
D
Joshi
James
J
Field
John
J
Murphy
Mohammed
M
Abdelrahim
Heike
H
Schönherr
Janet R
JR
Sparrow
George
G
Ellestad
Koji
K
Nakanishi
Arie
A
Zask
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008027:Light; D008062:Lipofuscin / Q000502:physiology; D008268:Macular Degeneration / Q000517:prevention & control*; D015394:Molecular Structure; D010857:Pigment Epithelium of Eye / Q000187:drug effects; D011726:Pyridinium Compounds / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011794:Quercetin / Q000494:pharmacology; D012176:Retinoids / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
C112040:A2-E (N-retinylidene-N-retinylethanolamine); D000975:Antioxidants; D008062:Lipofuscin; D011726:Pyridinium Compounds; D012176:Retinoids; D011794:Quercetin