Altered Kir and gap junction channels in temporal lobe epilepsy.
Since astrocytes may sense and respond to neuronal activity these cells are now considered important players in brain signaling. Astrocytes form large gap junction coupled syncytia allowing them to clear the extracellular space from K⁺ and neurotransmitters accumulating during neuronal activity, and redistribute it to sites of lower extracellular concentrations. Increasing evidence suggests a crucial role for dysfunctional astrocytes in the etiology of epilepsy. Notably, alterations in expression, localization and function of astroglial K⁺ channels as well as impaired K⁺ buffering was observed in specimens from patients with pharmacoresistant temporal lobe epilepsy and in chronic epilepsy models. Altered astroglial gap junction coupling has also been reported in epileptic tissue which, however, seems to play a dual role: (i) junctional coupling counteracts hyperactivity by facilitating clearance of elevated extracellular K⁺ and glutamate while (ii) it also provides a pathway for energetic substrates and fuels neuronal activity. Dysfunctional astrocytes should be considered promising targets for new therapeutic strategies.
Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany. Electronic address: Peter.bedner@ukb.uni-bonn.de.
Peter
P
Bedner
Christian
C
Steinhäuser
D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D017629:Gap Junctions / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology*
D007473:Ion Channels
Astrocyte; Cx30; Cx43; Dye coupling; Epilepsy; Kir4.1