Direct ortho-arylation of ortho-substituted benzoic acids: overriding Pd-catalyzed protodecarboxylation.
ortho-Arylation of ortho-substituted benzoic acids is a challenging process due to the tendency of the reaction products toward Pd-catalyzed protodecarboxylation. A simple method for preventing decarboxylation in sterically hindered benzoic acids is reported. The method described represents a reliable and broadly applicable entry to 2-aryl-6-substituted benzoic acids.
Queen Mary University of London, School of Biological and Chemical Sciences, Joseph Priestley Building, Mile End Road, London E1 4NS, United Kingdom.
Carlos
C
Arroniz
Alan
A
Ironmonger
Gerry
G
Rassias
Igor
I
Larrosa
D001565:Benzoates / Q000138:chemical synthesis* / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry*; D002384:Catalysis; D003653:Decarboxylation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry*
D001565:Benzoates; D002254:Carbonates; D010165:Palladium; C037593:potassium carbonate; D011188:Potassium