The CD70-CD27 axis, a new brake in the T helper 17 cell response.
The CD70-CD27 interaction is known to positively regulate T cell expansion and effector function by providing costimulatory signals. In this issue of Immunity, Coquet et al. (2013) show an unexpected T-helper-17-cell-specific negative regulation mediated by CD70-CD27 interaction.
Department of Immunology, M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Xiaohu
X
Wang
Chen
C
Dong