Changes in cardiovascular risk factors over a 24-year follow-up period: a Japanese pediatric cohort study.
This study examined changes in body mass index (BMI), fasting blood sugar (FBS), total cholesterol (TC) and HDL-cholesterol (HDL-C) levels over a 24-year follow-up period in a pediatric cohort. An appropriate starting age for intervention to prevent cardiovascular diseases is still unclear. The subjects were 655 children, aged 10-12. A follow-up survey was conducted when the subjects reached ages 13-15, 16-18, and 35-45, respectively, and height, weight, and blood tests including FBS, TC and HDL-C were examined. Forty (6%) of these subjects participated. BMI at ages 35-45 were significantly higher than those at ages 10-12 (p < 0.0001), 13-15 (p < 0.001), and 16-18 (p < 0.001). TC levels at ages 35-45 were significantly higher than at ages 10-12 (p < 0.0001), 13-15 (p < 0.0001), and 16-18 (p < 0.0001). BMI at the end of the follow-up (ages 35-45) had a significant correlation with BMI at ages 13-15 (R = 0.38, p = 0.041) and 16-18 (R = 0.41, p = 0.049). TC and HDL-C values at the end of the follow-up had a significant correlation with those at ages 10-12 (R = 0.55, p = 0.0004; R = 0.55, p = 0.016), 13-15 (R = 0.35, p = 0.045; R = 0.42, p = 0.015), and 16-18 (R = 0.47, p = 0.019; R = 0.44, p = 0.028). These results may suggest that intervention for children in Japan with cardiovascular risk factors should be initiated in the early years of life.
Asa Cohort Study Committee of Hiroshima Prefectural Asa Medical Association, Hiroshima, Japan. mkuwabar@urban.ne.jp
Masahiko
M
Kuwabara
Masaharu
M
Yoshihara
Hiroko
H
Hirata
Hirotoshi
H
Sugino
Katsushi
K
Asaoka
Haruyasu
H
Kondo
Kazuo
K
Fujii
Hideki
H
Matsubara
Takashi
T
Nakagawa
Masanori
M
Horie
Hitoshi
H
Ito
Haruyuki
H
Matsumoto
Takuhiro
T
Okamoto
Toru
T
Hiyama
Takahiro
T
Sumiya
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors
D008076:Cholesterol, HDL; D002784:Cholesterol