Coordination chemistry for antibacterial materials: a monolayer of a Cu(2+) 2,2'-bipyridine complex grafted on a glass surface.
A propyltrimethoxysilane-modified 2,2'-bipyridine ligand is synthesized and its acetonitrile solutions are used to prepare monolayers of the molecule on glass surfaces. Absorption and X-ray photoelectron spectroscopy demonstrate that the modified glass surfaces bind Cu(2+) with a 1:1 ratio with respect to the 2,2'-bipyridine moieties under the chosen preparative conditions, producing materials bearing 0.016 μg cm(-2) of copper. Although in trace amounts, the bound Cu(2+) cations exert a significant microbicidal effect against Escherichia coli and Staphylococcus aureus.
inLAB, Dipartimento di Chimica, Università di Pavia, viale Taramelli, 12, 27100 Pavia, Italy. piersandro.pallavicini@unipv.it
Piersandro
P
Pallavicini
Giacomo
G
Dacarro
Pietro
P
Grisoli
Carlo
C
Mangano
Maddalena
M
Patrini
Federica
F
Rigoni
Luigi
L
Sangaletti
Angelo
A
Taglietti
D015082:2,2'-Dipyridyl / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005898:Glass / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D012821:Silanes / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D012821:Silanes; D015082:2,2'-Dipyridyl; D003300:Copper