A computational multiscale model of glioblastoma growth: regulation of cell migration and proliferation via microRNA-451, LKB1 and AMPK.
A new computational multiscale model of glioblastoma growth is introduced. This model combines an agent-based model for representing processes on the cellular level with a molecular interaction network for each cell on the subcellular scale. The network is based on recently published work on the interaction of microRNA-451, LKB1 and AMPK in the regulation of glioblastoma cell migration and proliferation. We translated this network into a mathematical description by the use of 17 ordinary differential equations. In our model, we furthermore establish a link from the molecular interaction network of a single cell to cellular actions (e.g. chemotactic movement) on the microscopic level. First results demonstrate that the computational model reproduces a tumor cell development comparable to that observed in in vitro experiments.
Institute of Medical Engineering, University of Luebeck, 23562 Luebeck, Germany. fschuetz@imt.uni-luebeck.de
Tina A
TA
Schuetz
Stefan
S
Becker
Andreas
A
Mang
Alina
A
Toma
Thorsten M
TM
Buzug
D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism; D002465:Cell Movement; D049109:Cell Proliferation; D002633:Chemotaxis; D003198:Computer Simulation; D005909:Glioblastoma / Q000473:pathology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D015233:Models, Statistical; D010641:Phenotype; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
C531201:MIRN451 microRNA, human; D035683:MicroRNAs; D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose