Susceptibility of human iris stromal cells to herpes simplex virus 1 entry.
Ocular herpes simplex virus 1 (HSV-1) infection can lead to multiple complications, including iritis, an inflammation of the iris. Here, we use human iris stroma cells as a novel in vitro model to demonstrate HSV-1 entry and the inflammatory mediators that can damage the iris. The upregulated cytokines observed in this study provide a new understanding of the intrinsic immune mechanisms that can contribute to the onset of iritis.
Department of Microbiology & Immunology, Midwestern University, Downers Grove, Illinois, USA.
John
J
Baldwin
Paul J
PJ
Park
Brian
B
Zanotti
Erika
E
Maus
Michael V
MV
Volin
Deepak
D
Shukla
Vaibhav
V
Tiwari
D000818:Animals; D016466:CHO Cells; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D016207:Cytokines / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology* / Q000821:virology; D005697:Galactosides; D049452:Green Fluorescent Proteins; D006367:HeLa Cells; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles; D007498:Iris / Q000166:cytology* / Q000821:virology; D007500:Iritis / Q000276:immunology* / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017154:Stromal Cells / Q000821:virology*; D053586:Virus Internalization
D016207:Cytokines; D005697:Galactosides; D007211:Indoles; D049452:Green Fluorescent Proteins; C044888:5-bromo-4-chloro-3-indolyl beta-galactoside