A mixed exercise training programme is feasible and safe and may improve quality of life and muscle strength in multiple myeloma survivors.
BACKGROUND
Exercise programmes are beneficial for cancer patients however evidence is limited in patients with multiple myeloma (MM), a cancer that is characterised by osteolytic bone disease, giving rise to high levels of bone morbidity including fractures and bone pain.


METHODS
We conducted a single arm phase 2 study of an exercise programme (EP) as rehabilitation for treated MM patients, to evaluate feasibility, effects on QOL and physiological parameters. Patients were given individualised programmes, comprising stretching, aerobic and resistance exercises, carried out under supervision for 3 months then at home for a further 3 months.


RESULTS
Study uptake was high, 60 of 75 (80%) patients approached consented to the study. Screen failures (11, due to fracture risk and disease relapse) and patient withdrawals (12) resulted in a final 37 patients enrolling on the programme. These 37 patients demonstrated high attendance rates in the supervised classes (87%), and high levels of adherence in home exercising (73%). Patients reported better QOL following the EP, with improvement in FACT-G and Fatigue scores over time from baseline (p<0.01 for both, one-way repeated measures ANOVA) to 6 months. Upper and lower limb strength also improved on the EP, from baseline to 6 months (p<0.01 for both). There were no adverse reactions.


CONCLUSIONS
An EP in MM patients is feasible and safe, with high attendance and adherence. Benefits in QOL, fatigue and muscle strength await confirmation in randomized studies, prompting urgent evaluation of the benefits of EP in the rehabilitation of MM patients.
Cancer Institute, University College London, 72 Huntley Street, WC1E 6DD, London, UK.
Lara
L
Groeneveldt
Gill
G
Mein
Rachel
R
Garrod
Andrew P
AP
Jewell
Ken
K
Van Someren
Richard
R
Stephens
Shirley P
SP
D'Sa
Kwee L
KL
Yong
D000368:Aged; D005081:Exercise Therapy / Q000009:adverse effects / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D017144:Focus Groups; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D053580:Muscle Strength / Q000502:physiology*; D052580:Muscle Stretching Exercises; D010865:Pilot Projects; D015397:Program Evaluation; D011788:Quality of Life; D017741:Survivors / Q000523:psychology