[Analysis of efficacy of prevention and antioxidant therapy in premature infants].
282 (564 eyes) premature infants born at mean 27 +/- 2,5 weeks of gestation with birth weight 914+/- 247g were enrolled in the study. Comparative study showed preventive treatment with histochrome in infants with risk of retinopathy of prematurity (RP) to decrease the incidence of RP compared to infants treated with emoxipine and no antioxidant therapy. Incidence of RP in infants preventively treated with combination antioxidant agents (dicynon and emoxipine) was significantly lower compared to the group without preventive antioxidant treatment. Use of histochrome in treatment of RP via periocular injections and forced instillations promoted more favorable outcome of the disease.
G V
GV
Nikolaeva
M R
MR
Guseva
M B
MB
Beslaneeva
D000975:Antioxidants / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007322:Instillation, Drug; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D012178:Retinopathy of Prematurity / Q000453:epidemiology / Q000517:prevention & control*; D012189:Retrospective Studies; D012426:Russia / Q000453:epidemiology; D016896:Treatment Outcome
D000975:Antioxidants; D009883:Ophthalmic Solutions