Controlled branching of polyglycidol and formation of protein-glycidol bioconjugates via a graft-from approach with "PEG-like" arms.
The control of the branching in polyglycidols as semibranched alternatives to traditional polyglycidols is presented. The relative abundance of dendritic carbons is lowered by five-fold compared to hyperbranched polyglycidols. It is the first example of tailoring the branching in polyglycidol and creating protein-glycidol bioconjugates as alternatives to pegylated biostructures.
Vanderbilt University, Department of Chemistry, 7619 Stevenson Center, Nashville, Tennessee, USA.
Benjamin R
BR
Spears
Julian
J
Waksal
Caitlin
C
McQuade
Laura
L
Lanier
Eva
E
Harth
D000818:Animals; D002417:Cattle; D004852:Epoxy Compounds / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism
D004852:Epoxy Compounds; D011108:Polymers; D020005:Propanols; D011409:Propylene Glycols; D011506:Proteins; C502907:polyglycidol; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; C004312:glycidol