Biomarkers of oxidative damage are elevated among individuals with high cardiovascular risk: refining subject selection strategies for antioxidant trials.
The purpose of this study was to evaluate the use of Framingham risk scores (FRRs) to identify high-risk individuals with biochemical evidence of increased oxidative damage, who may benefit from antioxidant therapies. A bimodal change in plasma F2-isoprostane levels was observed with cardiovascular risk categories, while plasma neuroprostanes, 7α-hydroxycholesterol, and serum γ-glutamyltransferase levels were higher among individuals at high risk of cardiovascular events (Framingham score, > 36). Total plasma hydroxyeicosatetraenoic acid products (HETEs) and serum high-sensitivity CRP (hsCRP) levels were consistently higher across Framingham risk categories. Multivariable analysis identified plasma 7α-hydroxycholesterol (odds ratio (OR), 1.06; 95% confidence interval (CI), 1.03-1.10) and γ-glutamyltransferase (OR, 1.02; 95% CI, 1.01-1.03) as significant predictors of high cardiovascular risk (Framingham score, > 36), accounting for approximately 21% of its variation. Cardiovascular risk scores are useful to identify individuals with high burden of oxidative damage who may benefit from antioxidant therapy.
Department of Medicine, National University Health System, Kent Ridge Road, Singapore. raymond_seet@nus.edu.sg
Raymond C S
RC
Seet
Amy M L
AM
Quek
Erle C H
EC
Lim
Barry
B
Halliwell
D000975:Antioxidants / Q000008:administration & dosage; D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy; D002986:Clinical Trials as Topic; D028441:F2-Isoprostanes / Q000097:blood*; D006801:Humans; D006888:Hydroxycholesterols / Q000097:blood*; D018384:Oxidative Stress; D057285:Precision Medicine; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000097:blood*
D000975:Antioxidants; D028441:F2-Isoprostanes; D006888:Hydroxycholesterols; C011724:cholest-5-en-3 beta,7 alpha-diol; D005723:gamma-Glutamyltransferase