Reliability of two clinically relevant fiber pathways reconstructed with constrained spherical deconvolution.
The single diffusion tensor model is inadequate for the reconstruction of fiber pathways in brain regions with multiple fiber orientations. To overcome this limitation, constrained spherical deconvolution has been proposed. A high reliability of constrained spherical deconvolution is, however, a pre-requisite for its use in clinical applications. Reliability of reconstructed fiber pathways can be assessed in terms of architectural (addressing their spatial configuration) and microstructural (addressing diffusion-derived measures along the fibers) reproducibility. We assess the reliability for two clinically relevant fiber pathways: the corticospinal tract and arcuate fasciculus. The fiber pathways were reconstructed using constrained spherical deconvolution in 11 healthy subjects who were scanned on three occasions. Coefficients of variations of diffusion-derived measures were used to assess the microstructural reproducibility. Image correlation and fiber overlap were used to assess the architectural reproducibility. The mean correlation between sessions was 72% for both the corticospinal tract and arcuate fasciculus. The mean overlap between sessions was 63% for the corticospinal tract and 58% for the arcuate fasciculus. Coefficients of variations of diffusion-derived measures showed very low variation (all measures <3.1%). These results are comparable with reliability results based on the diffusion tensor model, which is commonly used in clinical settings. The reliability results found here are, therefore, promising to further investigate the use of constrained spherical deconvolution in clinical practice.
Department of Medical Psychology and Neuropsychology, University of Tilburg, Tilburg, The Netherlands; Department of Neurosurgery, St. Elisabeth Hospital, Tilburg, The Netherlands; Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
Gert
G
Kristo
Alexander
A
Leemans
Mathijs
M
Raemaekers
Geert-Jan
GJ
Rutten
Beatrice
B
de Gelder
Nick F
NF
Ramsey
D000328:Adult; D000465:Algorithms; D002540:Cerebral Cortex / Q000166:cytology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D010363:Pattern Recognition, Automated / Q000379:methods*; D011712:Pyramidal Tracts / Q000166:cytology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
arcuate fasciculus; constrained spherical deconvolution; corticospinal tract; neurology; neurosurgery; test-retest reliability