Zamamiphidin A, a new manzamine related alkaloid from an Okinawan marine sponge Amphimedon sp.
A manzamine related alkaloid, zamamiphidin A (1), consisting of a new heptacyclic ring system has been isolated from an Okinawan marine sponge Amphimedon sp. The structure of 1 including the relative stereochemistry was elucidated on the basis of the spectroscopic data. Compound 1 showed antibacterial activity against Staphylococcus aureus (MIC, 32 μg/mL).
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Takaaki
T
Kubota
Yuki
Y
Kamijyo
Azusa
A
Takahashi-Nakaguchi
Jane
J
Fromont
Tohru
T
Gonoi
Jun'ichi
J
Kobayashi
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002227:Carbazoles; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D002227:Carbazoles; C581423:zamamiphidin A; C078290:manzamine A