Injectable macroporous microparticles for soft tissue augmentation.
Macroporous polymeric microparticles have been fabricated using a combination of particulate leaching and gas foaming techniques. Controlling the concentration of ammonium bicarbonate particles and the spin speed of the microemulsion in poly (ε-caprolactone) (PCL) yields a range of macroporous microparticles with interconnected pores (10-50 µm) that may promote cell and tissue ingrowth in vivo when implanted subcutaneously. This fabrication technique introduces a novel template which can be modified to meet a diverse set of material and biological specifications.
Bioengineering Department, University of California Los Angeles. Los Angeles, CA 90095, USA. acorrin@ucla.edu
Abigail A
AA
Corrin
Matthew
M
Ngai
Christopher M
CM
Walthers
James C Y
JC
Dunn
Benjamin M
BM
Wu
D040761:Biomimetic Materials / Q000008:administration & dosage* / Q000737:chemistry*; D003358:Cosmetics / Q000008:administration & dosage* / Q000737:chemistry*; D007267:Injections; D008422:Materials Testing; D008863:Microspheres; D011091:Polyesters / Q000008:administration & dosage* / Q000138:chemical synthesis*; D016062:Porosity
D003358:Cosmetics; D011091:Polyesters; C016240:polycaprolactone