On-demand controlled release of anti-inflammatory and analgesic drugs from conducting polymer films to aid in wound healing.
An electronically-controlled drug delivery system (eDDS) for the on-demand release of anti-inflammatory, anti-microbial and analgesic agents to aid in wound healing is currently under development. The loading of several drugs into conductive polymer films and their subsequent on-demand, controlled release upon application of an electrical potential to the polymer film has been demonstrated. The loading and release (active and passive) of Ibuprofen sodium salt - a negatively charged analgesic and anti-inflammatory agent - from polypyrrole films is described. Major challenges identified include precise control over drug loading and passive release from the conducting polymers in the absence of an applied potential.
Crosslink™, Fenton, MO, USA. gjustin@crosslinkusa.com
Gusphyl A
GA
Justin
Siqiang
S
Zhu
Theodore R
TR
Nicholson
Jeffrey
J
Maskrod
Joseph
J
Mbugua
Mark
M
Chase
June-ho
JH
Jung
Ramil Marcelo L
RM
Mercado
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002460:Cell Line; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D004566:Electrodes; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D008422:Materials Testing; D008567:Membranes, Artificial; D011108:Polymers / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008567:Membranes, Artificial; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D007052:Ibuprofen