Vitamin E, Its Beneficial Role in Diabetes Mellitus (DM) and Its Complications.
BACKGROUND
Studies have shown that diabetes is accompanied by an increased oxidative damage to all the bimolecular. Enhanced oxidative stress contributes to the development of the diabetic complications. The key lipid soluble chain breaking antioxidant,-tocopherol, is known to be deficient in diabetes. Human intervention studies have indicated the role of vitamin E in improving the endothelial function, the retinal blood flow and the renal dysfunction. The aim of the study was to find the role of vitamin E in preventing the development and the progression of the diabetic complications.


METHODS
Both type I and II DM patients with and without complications were included in this study. They were divided separately into the test (which received insulin/oral hypoglycemic and vitamin E) and the control groups (which received only insulin/oral hypoglycemic drugs). The Fasting Blood Sugar(FBS), Post-prandial Blood Sugar(PPBS) and the Total Cholesterol(TC) were estimated and the Blood Pressure (BP) was noted at 0(beginning),12,18 and 24 months. Cardiovascular disease, retinopathy, nephropathy and foot ulcer development and progression were monitored. The data was analyzed by the Z test for the means and for the proportions.


RESULTS
It was evident from the analysis of the data that the PPBS, TC and the Diastolic Blood Pressure (DBP) declined gradually and significantly in the test groups. This was a beneficial development for the diabetic patients. The patients who were on the vitamin E supplementation had a delayed development and a slow progression of the complications.


CONCLUSIONS
Vitamin E supplementation has an important role in delaying the onset of the diabetic complications as well as for slowing down the progression of the complications.
Associate Professor,  Department of Pharmacology, Chettinad Academy of Research and Education ,  Chettinad Health City Campus, Rajiv Gandhi Salai, Kelambakkam, Kancheepuram, Tamil Nadu 603013, India.
Anand
A
Baburao Jain
Vaishali
V
Anand Jain
Antioxidant; Diabetes mellitus; Diabetic complications