Reactions of difluorocarbene with organozinc reagents.
Reactions of difluorocarbene with benzyl and alkylzinc halides leading to fluorinated organozinc species have been described. The generated α-difluorinated organozinc reagents are reasonably stable in solution and can be quenched with external electrophiles (iodine, bromine, proton), affording compounds containing the CF(2) fragment.
N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation.
Vitalij V
VV
Levin
Artem A
AA
Zemtsov
Marina I
MI
Struchkova
Alexander D
AD
Dilman
D001966:Bromine; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D009942:Organometallic Compounds; C121084:difluorocarbene; D015032:Zinc; D001966:Bromine