Frequency of MYO9B polymorphisms in celiac patients and controls.
BACKGROUND
the MYO9B gene contributes to the maintenance of the intestinal barrier and it has been postulated as a risk factor of celiac disease (CD). The objective of this study was to compare the frequency and association rs2305764, rs2305767 and rs1457092 MYO09B polymorphisms in pediatric CD patients from and.


METHODS
the study was made in 104 CD pediatric patients (Chilean and Argentineans) and 104 controls subjects. MYO9B gene polymorphisms were analyzed by Taqman allelic probes. We evaluated the Hardy-Weinberg equilibrium by means of Chi-square and compared the haplotypes distribution using Fisher test.


RESULTS
SNPs rs2305767 and rs1457092 were associated with celiac disease (CD); TT genotype in rs2305767 would be a protective factor (p < 0.000, OR = 0.19 CI 0.1-0.4) and the CT genotype would be a risk factor (p < 0.0001, OR = 4.9 CI 2.2 to 11.3). CC genotype in rs1457092 also showed a protective effect for celiac (p < 0.000, OR = 0.07 CI 0.0 to 0.3).


CONCLUSIONS
our findings suggest that genetic variation MYO9B gene is associated with CD, as a protective or a risk factor depending on the polymorphism studied.
Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.
Tamara
T
Loeff
Magdalena
M
Araya
Francisco
F
Pérez-Bravo
D000293:Adolescent; D001118:Argentina / Q000453:epidemiology; D002446:Celiac Disease / Q000453:epidemiology* / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007223:Infant; D008297:Male; D009218:Myosins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
D006680:HLA Antigens; C113469:myosin IXB; D009218:Myosins