A case of neonatal human parechovirus encephalitis with a favourable outcome.
Human parechoviruses (HPeVs) are a new family of neurotropic viruses that cause central nervous system (CNS) infections similar to enterovirus (EVs) meningoencephalitis in the neonatal period, resulting in white matter lesions that can be visualized with cranial ultrasonography and magnetic resonance imaging, and correlated to a large spectrum of neurological outcomes. HPeV should be suspected in neonates with signs and symptoms of sepsis-like illness or CNS disease. We report a case of neonatal HPeV encephalitis, diagnosed on the basis of clinical and radiological findings and HPeV RT-PCR, with a good neurological outcome.
Emergency Department of Paediatrics, G. Gaslini Children's Hospital, Genova, Italy.
Salvatore
S
Renna
Emergency Department of Paediatrics, G. Gaslini Children's Hospital, Genova, Italy. Electronic address: gemelsberga@libero.it.
Laura
L
Bergamino
Emergency Department of Paediatrics, G. Gaslini Children's Hospital, Genova, Italy.
Daniela
D
Pirlo
Neuroradiology Department, G. Gaslini Children's Hospital, Genova, Italy.
Andrea
A
Rossi
Molecular Virology Unit, Virology and Microbiology Department, IRCCS San Matteo, Pavia, Italy.
Milena
M
Furione
Molecular Virology Unit, Virology and Microbiology Department, IRCCS San Matteo, Pavia, Italy.
Antonio
A
Piralla
Child Neurology and Psychiatry Unit, G. Gaslini Children's Hospital, Genova, Italy.
Monica
M
Mascaretti
Infectious Diseases Unit, G. Gaslini Children's Hospital, Genova, Italy.
Emilio
E
Cristina
Faculty of Medicine, University of Genova, Infectious Diseases Unit, G. Gaslini Children's Hospital, Genova, Italy. Electronic address: mgraziamarazzi@ospedale-gaslini.ge.it.
Maria Grazia
MG
Marazzi
Emergency Department of Paediatrics, G. Gaslini Children's Hospital, Genova, Italy.
Pasquale
P
Di Pietro
D002648:Child; D018792:Encephalitis, Viral / Q000209:etiology*; D004769:Enterovirus Infections / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D030061:Parechovirus / Q000235:genetics / Q000472:pathogenicity*
CNS; CSF; DWI; EV; Enterovirus; HPeV; ICU; MRI; Magnetic resonance imaging; Neonatal encephalitis; Parechovirus; RT-PCR; central nervous system; cerebral spinal fluid; diffusion-weighted imaging; human enterovirus; human parechovirus; intensive care unit; magnetic resonance imaging; reverse transcription polymerase chain reaction