Clinical implications of periostin in the liver metastasis of colorectal cancer.
OBJECTIVE
To investigate the expression status of periostin in colorectal cancer (CRC) to lay a foundation for managing this disease.


METHODS
Periostin expression status was detected by immunohistochemistry staining in 720 CRC specimens. The relationship between the periostin protein and clinicopathological factors and prognosis was subsequently determined.


RESULTS
The periostin protein was expressed significantly higher in CD133+ tumor cells compared to CD133- tumor cells. Positively expressed periostin was observed in 218 (30.28%) of the 720 cases. Spearman correlation analysis showed that periostin expression has a linear correlation to the tumor size, histological type, lymph node metastasis, TNM stage, and postoperative liver metastasis (p=0.02, 0.035, 0.001, 0.001, and 0.001, respectively). Multivariate analysis showed that histological type, lymph node metastasis, TNM stage, and periostin were found to be related to liver metastasis (p=0.01, 0.035, 0.01, and 0.001, respectively). In the Cox regression test, the histological grade, Lymph node metastasis, TNM stage, and periostin were detected as independent prognostic factors (p=0.01, 0.001, 0.001, and 0.001, respectively).


CONCLUSIONS
Periostin was found to be related to the liver metastasis of CRC and may be a potential target for CRC.
1 Department of General Surgery, The General Hospital of ShenYang Military Area Command , Shenyang, China .
Guoqiang
G
Wu
Xiaochen
X
Wang
Xuefeng
X
Zhang
D000071916:AC133 Antigen; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D014411:Neoplastic Stem Cells / Q000737:chemistry; D010455:Peptides / Q000032:analysis; D011379:Prognosis; D015996:Survival Rate; D047368:Tumor Burden
D000071916:AC133 Antigen; D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; C512835:POSTN protein, human; C000606023:PROM1 protein, human; D010455:Peptides
cancer stem cell; colorectal cancer; periostin; prognosis