Continuous coaxial electrohydrodynamic atomization system for water-stable wrapping of magnetic nanoparticles.
An electrohydrodynamic atomization (EHDA) system that generates an electrospray can achieve particle formation and encapsulation by accumulating an electric charge on liquid flowing out from the nozzle. A novel coaxial EHDA system for continuous fabrication of water-stable magnetic nanoparticles (MNPs) is established, based on a cone-jet mode of electrospraying. Systemic variables, such as flow rates from dual nozzles and inducing voltages, are controlled to enable the preparation of water-soluble MNPs coated by polysorbate 80. The PEGylated MNPs exhibit water stability. The magnetic resonance imaging potential of these MNPs is confirmed by in vivo imaging using a gastric cancer xenograft mouse model. Thus, this advanced coaxial EHDA system demonstrates remarkable capabilities for the continuous encapsulation of MNPs to render them water-stable while preserving their properties as imaging agents.
Department of Mechanical Engineering, Yonsei University, Seoul 120-749, Republic of Korea.
Sang-Yoon
SY
Kim
Jaemoon
J
Yang
Bongjune
B
Kim
Jungmin
J
Park
Jin-Suck
JS
Suh
Yong-Min
YM
Huh
Seungjoo
S
Haam
Jungho
J
Hwang
electrohydrodynamic atomization; encapsulation; magnetic materials; magnetic resonance imaging; nanoparticles