SIADH and partial hypopituitarism in a patient with intravascular large B-cell lymphoma: a rare cause of a common presentation.
Hyponatraemia is a very common electrolyte abnormality with varied presenting features depending on the underlying cause. The authors report the case of a 75-year-old, previously fit, gentleman who presented with weight loss, lethargy and blackouts. He required four admissions to the hospital over an 8-month period. Investigations revealed persistent hyponatraemia consistent with a diagnosis of syndrome of inappropriate antidiuretic hormone secretion, macrocytic anaemia and partial hypopituitarism. Unfortunately, all other investigations that were performed failed to identify the underlying cause and a diagnosis of intravascular large B-cell lymphoma was only confirmed following postmortem studies. The authors recommend that endocrinologists should be involved at the outset in the management of patients with persistent hyponatraemia and that intravascular large B-cell lymphoma should be considered in the differential diagnosis of hyponatraemia.
Department of Endocrine,  Southport and Ormskirk Hospitals NHS Trust, Southport,  UK.
Simeen
S
Akhtar
Edmund
E
Cheesman
Edward B
EB
Jude
D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D007010:Hyponatremia / Q000209:etiology; D007018:Hypopituitarism / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D019043:Vascular Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology