Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male.
Many aging male suffer various andropause symptoms including loss of physical and mental activities. This study evaluated the putative alleviative effects of CRS-10 dandelion and rooibos extract complex (CRS-10) on the symptoms of andropause. The survival rate of TM3 Leydig cells (TM3 cells) treated with CRS-10 was measured based on typical physiological stress. After daily intake of CRS-10 for 4 weeks, the level of testosterone, physical activity and both the number and activity of sperm in older rats (18 weeks) were measured. Furthermore, thirty males were surveyed with AMS (Aging Males' Symptoms) questionnaire after intake of 400 mg of CRS-10. Overall, CRS-10 protected TM3 cells from serum restriction and oxidative stress via activation of ERK and Akt pathways. The level of testosterone and activation of spermatogenesis in rats were significantly enhanced. In addition, physical locomotion was markedly improved. Daily intake of 400 mg of CRS-10 improved the quality of life among agingmale respondents, according to a clinical survey using the AMS. The results indicate the potential of CRS-10 as a safe and efficacious natural substance for reducing or alleviating andropause symptoms.
Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.
Yoo-Hun
YH
Noh
Do-Hee
DH
Kim
Joon Yub
JY
Kim
Jiae
J
Park
Ok Hyeon
OH
Kim
Daeseok
D
Han
Won-Yong
WY
Kim
Sung-Su
SS
Kim
Moo-Yeol
MY
Lee
Seok-Hyun
SH
Heo
Misook
M
Kim
Won Bok
WB
Lee
Yoonhwa
Y
Jeong
Soon Chul
SC
Myung
CRS-10; Leydig cell; andropause; spermatogenesis; testosterone