[The Janus face of monoclonal antibodies in oncology: passive immunity and vaccination].
Monoclonal antibodies used in oncology exert direct anti-tumor action leading to cancer cell death. This is due to a variety of mechanisms, ranging from the induction of apoptosis to the recruitment of effector cells from the innate immunity. However, antibodies can also induce long-lasting anti-tumor effects thanks to the induction of an adaptive immunity where CD4(+) and CD8(+) T cells play a central role. Different preclinical experimental models, strengthened by a few clinical observations, have shown that, far from being involved only in passive immunotherapy, monoclonal antibodies used in oncology are also endowed with a "vaccine" effect, inducing immune memory, likely responsible for the long-lasting clinical responses that have been sometimes observed. This capacity of triggering/re-installing tumor immune surveillance could be also reinforced by the use, possibly in combination, of antibodies antagonizing molecules such as CTLA-4 or PD-1 that play a key role in the inhibition of the anti-tumor immune responses. Finally, this novel paradigm of therapeutic anti-tumor antibodies as inducers of anti-tumor adaptive immune responses with long-term memory should lead us to re-examine how antibody treatment, chemotherapy, radiotherapy, and biological response modifiers are combined, in particular both in terms of timing and doses.
Centre de recherche des Cordeliers, Inserm U872, université Paris-Descartes, université Pierre et Marie Curie, 15, rue de l'École de médecine, 75270 Paris Cedex 06, France. claire.deligne@gmail.com
Claire
C
Deligne
Jean-Luc
JL
Teillaud
D056704:Adaptive Immunity; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D019496:Cancer Vaccines; D006801:Humans; D007116:Immunization, Passive; D009369:Neoplasms / Q000628:therapy*; D014611:Vaccination
D000911:Antibodies, Monoclonal; D019496:Cancer Vaccines