Primary peritoneal cancer in Lynch syndrome: a clinical-pathologic report of a case and analysis of the literature.
Lynch syndrome is a genetic disease, caused by a germ-line mutation in a mismatch repair gene, related to an increased risk of developing colorectal and extracolonic cancer. Despite that, the incidence of primary peritoneal cancer after adnexectomy remains unknown. We here report a case of primary peritoneal cancer in a woman affected by Lynch syndrome who underwent hysterectomy+salpingo-oophorectomy for endometrial cancer 13 yr before. Morphology and immunophenotype allowed to differentiate peritoneal malignancy from the previously diagnosed endometrial carcinoma. Physicians should be aware of the potential risk of primary peritoneal cancer in women affected by Lynch syndrome, despite previous prophylactic surgery.
Department of Obstetrics and Gynecology, University of Insubria, Varese, Italy.
Fabio
F
Ghezzi
Stefano
S
Uccella
Antonella
A
Cromi
Giorgio
G
Bogani
Nicoletta
N
Donadello
Cristina
C
Riva
D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications* / Q000235:genetics; D016889:Endometrial Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery; D005260:Female; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D051718:MutS Homolog 2 Protein / Q000235:genetics; D010052:Ovariectomy; D010534:Peritoneal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D058994:Salpingectomy
C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein