mRNAStab--a web application for mRNA stability analysis.
Eukaryotic gene expression is regulated both at the transcription and the mRNA degradation levels. The implementation of functional genomics methods that allow the simultaneous measurement of transcription (TR) and degradation (DR) rates for thousands of mRNAs is a huge improvement in this field. One of the best established methods for mRNA stability determination is genomic run-on (GRO). It allows the measurement of DR, TR and mRNA levels during cell dynamic responses. Here, we offer a software package that provides improved algorithms for determination of mRNA stability during dynamic GRO experiments.
Department of Informatics and Department of Biochemistry and Molecular Biology, Universitat de València, 46100 Burjassot, Spain.
Andrei
A
Alic
José E
JE
Pérez-Ortín
Joaquín
J
Moreno
Vicente
V
Arnau
D000465:Algorithms; D023281:Genomics / Q000379:methods; D006801:Humans; D020407:Internet; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism*; D012984:Software
D012333:RNA, Messenger