Prediction of heart rate response to conclusion of the spontaneous breathing trial by fluctuation dissipation theory.
The non-equilibrium fluctuation dissipation theorem is applied to predict how critically ill patients respond to treatment, based upon data currently collected by standard hospital monitoring devices. This framework is demonstrated on a common procedure in critical care: the spontaneous breathing trial. It is shown that the responses of groups of similar patients to the spontaneous breathing trial can be predicted by the non-equilibrium fluctuation dissipation approach. This mathematical framework, when fully formed and applied to other clinical interventions, may serve as part of the basis for personalized critical care.
Physics & Astronomy Department, Rice University, Houston, TX, USA.
Man
M
Chen
Liang Ren
LR
Niestemski
Robert
R
Prevost
Michael
M
McRae
Sharath
S
Cholleti
Gabriel
G
Najarro
Timothy G
TG
Buchman
Michael W
MW
Deem
D003198:Computer Simulation; D003422:Critical Care; D016638:Critical Illness; D006339:Heart Rate; D006801:Humans; D008954:Models, Biological; D012119:Respiration; D012129:Respiratory Function Tests