No evidence for cardiac dysfunction in Kif6 mutant mice.
A KIF6 variant in man has been reported to be associated with adverse cardiovascular outcomes after myocardial infarction. No clear biological or physiological data exist for Kif6. We sought to investigate the impact of a deleterious KIF6 mutation on cardiac function in mice. Kif6 mutant mice were generated and verified. Cardiac function was assessed by serial echocardiography at baseline, after ageing and after exercise. Lipid levels were also measured. No discernable adverse lipid or cardiac phenotype was detected in Kif6 mutant mice. These data suggest that dysfunction of Kif6 is linked to other more complex biological/biochemical parameters or is unlikely to be of material consequence in cardiac function.
Department of Cardiovascular Science, Medical School, University of Sheffield, Sheffield, United Kingdom.
Abdul
A
Hameed
Ellen
E
Bennett
Barbara
B
Ciani
Loes P C
LP
Hoebers
Roy
R
Milner
Allan
A
Lawrie
Sheila E
SE
Francis
Andrew J
AJ
Grierson
D000818:Animals; D004452:Echocardiography; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D016547:Kinesins / Q000235:genetics / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D051379:Mice; D008817:Mice, Mutant Strains; D009154:Mutation; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics / Q000503:physiopathology
D008055:Lipids; D016547:Kinesins