Chemical proteomics: a powerful tool for exploring protein lipidation.
The study of post-translational modifications such as protein lipidation is a non-trivial challenge of the post-genomic era. In recent years the field of chemical proteomics has greatly advanced our ability to identify and quantify protein lipidation. In the present review, we give a brief overview of the tools available to study protein acylation, prenylation and cholesterylation, and their application in the identification and quantification of protein lipidation in health and disease.
Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Elisabeth M
EM
Storck
Remigiusz A
RA
Serwa
Edward W
EW
Tate
D000215:Acylation; D002784:Cholesterol / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D054878:Lipoylation; D008958:Models, Molecular; D015335:Molecular Probes; D019814:Myristic Acid / Q000737:chemistry; D019308:Palmitic Acid / Q000737:chemistry; D017368:Protein Prenylation; D011506:Proteins / Q000737:chemistry*; D040901:Proteomics
D008055:Lipids; D015335:Molecular Probes; D011506:Proteins; D019814:Myristic Acid; D019308:Palmitic Acid; D002784:Cholesterol