The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer.
A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue microarray. IGKC protein expression was independently associated with longer survival, with particular impact in the adenocarcinoma subgroup. Moreover, a correlation was seen with CD138+ cells, but not with CD20. CD138 expression revealed a comparable association with survival. In conclusion, IGKC expression in stroma-infiltrating plasma cells is a prognostic marker in NSCLC, supporting emerging treatment concepts that exploit the humoral immune response.
Dept. of Statistics, TU Dortmund University, Dortmund, Germany.
Miriam
M
Lohr
Karolina
K
Edlund
Johan
J
Botling
Seddik
S
Hammad
Birte
B
Hellwig
Amnah
A
Othman
Anders
A
Berglund
Mats
M
Lambe
Lars
L
Holmberg
Simon
S
Ekman
Michael
M
Bergqvist
Fredrik
F
Pontén
Cristina
C
Cadenas
Rosemarie
R
Marchan
Jan G
JG
Hengstler
Jörg
J
Rahnenführer
Patrick
P
Micke
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018951:Antigens, CD20 / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology* / Q000401:mortality* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D056724:Immunity, Humoral; D007145:Immunoglobulin kappa-Chains / Q000235:genetics* / Q000378:metabolism; D008175:Lung Neoplasms / Q000276:immunology* / Q000401:mortality* / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D017154:Stromal Cells / Q000276:immunology; D053668:Syndecan-1 / Q000378:metabolism; D046888:Tissue Array Analysis
D018951:Antigens, CD20; D007145:Immunoglobulin kappa-Chains; C508241:SDC1 protein, human; D053668:Syndecan-1