Preparation and characterization of superporous hydrogel based on different polymers.
BACKGROUND
Superporous hydrogel (SPH) swells very rapidly in a shorter period of time to an equilibrium size and contains highly porous structure.


OBJECTIVE
The synthesis of SPH of poly (acrylamide-co-acrylic acid) and its composites viz. Ac-Di-Sol and polyvinylpyrollidone (PVP) was carried out by solution polymerization.


METHODS
The SPH and SPH composites (SPHCs) were characterized by measurement of apparent density, porosity, swelling, mechanical strength, and scanning electron microscopy (SEM) studies.


RESULTS
FTIR studies confirmed the existence of acrylamide and acrylic acid in SPH. In distilled water SPH showed tremendous increase in equilibrium swelling capacity with conventional SPH as compared to its SPHCs of Ac-Di-Sol and PVP due to the increased in physical cross-linking network, respectively. The presence of Ac-Di-Sol and PVP in SPHCs increased the mechanical strength as compared to conventional SPH which is suitable for gastric retention. SEM pictures clearly indicated the formation of interconnected pores and capillary channels.


CONCLUSIONS
The amount and type of polymers used affect almost all the characterization parameters of SPHs, and hence, depending upon the applications perspective such polymers could be used in drug delivery systems, successfully.
Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Mehsana, Gujarat, India.
Hitesh V
HV
Chavda
Rupal D
RD
Patel
Ishan P
IP
Modhia
Chhagan N
CN
Patel
Ac-Di-Sol; PVP; mechanical strength; swelling