Randomized double-blind placebo-controlled trial of powdered Brassica rapa ethanol extract on alteration of body composition and plasma lipid and adipocytokine profiles in overweight subjects.
We evaluated the effects of Brassica rapa ethanol extract (BREE) on body composition and plasma lipid profiles through a randomized, double-blind, and placebo-controlled trial in overweight subjects. Fifty-eight overweight participants (age 20-50 years, body mass index23.0-24.9) were randomly assigned to two groups and served BREE (2 g/day) or placebo (starch, 2 g/day) for 10 weeks. Body compositions, nutrients intake, plasma lipids, adipocytokines, and hepatotoxicity biomarkers were assessed in all subjects at baseline and after 10 weeks of supplementation. The plasma total cholesterol (total-C) concentration was significantly increased after 10 weeks compared to the baseline in both groups. However, BREE supplementation significantly increased the high-density lipoprotein cholesterol (HDL-C) concentration and significantly reduced the total-C/HDL-C ratio, free fatty acid, and adipsin levels after 10 weeks. No significant differences were observed in body compositions, fasting blood glucose, plasma adipocytokines except adipsin, and aspartate aminotransferase and alanine aminotransferase activities between before and after trial within groups as well as between the two groups. The supplementation of BREE partially improves plasma lipid metabolism in overweight subjects without adverse effects.
Center for Food and Nutritional Genomics, Kyungpook National University, Daegu, Korea.
Seon-Min
SM
Jeon
Ji-Eun
JE
Kim
Su-Kyung
SK
Shin
Eun-Young
EY
Kwon
Un Ju
UJ
Jung
Nam-In
NI
Baek
Kyung-Tae
KT
Lee
Tae-Sook
TS
Jeong
Hae-Gon
HG
Chung
Myung-Sook
MS
Choi
D054392:Adipokines / Q000097:blood*; D000328:Adult; D001823:Body Composition / Q000187:drug effects*; D029741:Brassica rapa / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000378:metabolism; D055815:Young Adult
D054392:Adipokines; D008055:Lipids; D010936:Plant Extracts