Modern X-ray scattering studies of complex biological systems.
X-ray scattering is one of the most prominent structural characterization techniques in biology. The key advantage of X-ray scattering is its ability to penetrate and weakly interact with the bare studied materials. In addition, X-ray scattering does not require any tags, markers or modification to the sample under examination, and is not limited by the nature of the surrounding environment. The main handicapping limitation of X-ray scattering is the subject of particles polydispersity. However, the monodispersity in biological complexes and supra-molecular interactions makes them ideal for structural and interaction studies in particular when combined with higher (e.g. NMR) and/or lower resolution (e.g. optical microscopy) techniques. This review seeks to highlight some of the major recent achievements in the field of X-ray scattering as being implemented for complex biological systems.
The Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, 69978 Tel Aviv, Israel.
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M
Kornreich
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R
Avinery
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R
Beck
D000818:Animals; D006801:Humans; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction / Q000379:methods*; D015003:Yeasts / Q000737:chemistry / Q000166:cytology