Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes.
OBJECTIVE
To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.


METHODS
We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.


RESULTS
The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all P<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.


CONCLUSIONS
Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.
Department of Endocrinology, Fudan University, Shanghai, China.
Li
L
Sheng
Wenjie
W
Cao
Bingbing
B
Cha
Zhaoping
Z
Chen
Fang
F
Wang
Jun
J
Liu
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*
D015415:Biomarkers; D015675:Osteocalcin