Low-cost, flexible polymer arrays for long-term neuronal culture.
Conducting polymers are promising materials for fabrication of microelectrode arrays for both neural stimulation and recording. Our ability to engineer the morphology and composition of polypyrrole together with its suitability as an electrically addressable tissue/cell substrate have been used to develop an inexpensive, disposable three-dimensional polymeric array for use in neuronal culture and drug discovery. These arrays could be interfaced with a fixed, parallel stimulation and optical imaging system, amenable to automated handling and data analysis.
BioInstrumentation Laboratory in the Mechanical Engineering Department at Massachusetts Institute of Technology, Cambridge, MA 02139, USA. hog@mit.edu
N Catherine
NC
Hogan
Giovanni
G
Talei-Franzesi
Omar
O
Abudayyeh
Andrew
A
Taberner
Ian
I
Hunter
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D018929:Cell Culture Techniques / Q000295:instrumentation*; D017076:Computer-Aided Design; D004553:Electric Conductivity; D057166:High-Throughput Screening Assays; D006624:Hippocampus / Q000166:cytology; D008422:Materials Testing; D051379:Mice; D008839:Microelectrodes; D008855:Microscopy, Electron, Scanning; D009473:Neuronal Plasticity; D009474:Neurons / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D011108:Polymers / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry
D001672:Biocompatible Materials; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole