[Anti-HIV nucleoside drugs: retrospective view at future].
This review provides data on the design of antiretroviral drugs based on nucleoside analogs. About 30 drugs were approved for the treatment of HIV-infected patients over 25 years. Seven nucleoside drugs are inhibitors of HIV reverse transcriptase and clinically used in combination with inhibitors of other viral enzymes, integrase and protease, and non-nucleoside inhibitors of reverse transcriptase. Toxicity of nucleoside drugs and approaches to obtaining of safe anti-HIV drugs are discussed. The results of developing of domestic anti-HIV drugs are presented. The future prospects of anti-HIV investigations are considered.
M K
MK
Kukhanova
D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000266:history / Q000627:therapeutic use; D015195:Drug Design; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics / Q000266:history / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000266:history / Q000627:therapeutic use
D019380:Anti-HIV Agents; D009705:Nucleosides