[Effect of compound Chinese traditional medicine on periapical periodontitis in dogs and cytotoxic assay].
OBJECTIVE
To assess the efficacy of compound Chinese traditional medicine(CTM), which is composed of gallic acid, magnolol and polysaccharide of Bletilla, against apical periodontitis in dogs and cytotoxic assay.


METHODS
A animal model of apical periodontitis was built, CTM was then used to disinfect the root canal. The effect of the restoration of periapical bone in dogs was investigated after regular root canal filling. SAS6.12 software package was used for statistical analysis, and MTT was used to test cell toxicity of CTM.


RESULTS
CTM can cure inflammation effectively, and CTM had no cytotoxic effect on periodontal ligament cells at 5-week.


CONCLUSIONS
The compound Chinese traditional medicine may be an effective disinfecting drug for root canal disinfection.
Department of Endodontics, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, School of Medicine, China. marui6868@yahoo.com
Rui
R
Ma
Min-min
MM
Sun
Li-li
LL
Huang
Ting-ting
TT
Li
Wen-wei
WW
Xia
Cai-lian
CL
Zhu
Dong-xia
DX
Ye
D000818:Animals; D004285:Dogs; D008516:Medicine, Chinese Traditional; D010485:Periapical Periodontitis; D010513:Periodontal Ligament; D012389:Root Canal Obturation; D012390:Root Canal Therapy