[Streptomyces sp. 17, an organism producing oligomycin SC-iI (culture characteristics and antibiotic biological properties)].
Under the screening programme for organisms producing substances with hypolipidemic and antifungal activity Streptomyces sp. 17 was isolated. The taxonomic properties of the strain were investigated. Active compounds, i.e. oligomycin A and oligomycin SC-II were isolated from a complex biosynthetic product. Oligomycin A showed high antifungal activity whereas oligomycin SC-II had also moderate antibacterial activity.
M V
MV
Bibikova
N E
NE
Grammatikova
I A
IA
Spiridonova
A N
AN
Danilenko
A V
AV
Katlinskiĭ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D009840:Oligomycins / Q000302:isolation & purification / Q000494:pharmacology; D011817:Rabbits; D013302:Streptomyces / Q000145:classification* / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009840:Oligomycins; C031004:oligomycin A