Metastasis suppressor genes.
Metastasis is a major cause of cancer mortality. Metastasis is a complex process that requires the regulation of both metastasis-promoting and metastasis suppressor genes. The discovery of metastasis suppressor genes contributes significantly to our understanding of metastasis mechanisms and provides prognostic markers and therapeutic targets in clinical cancer management. In this review, we summarize the methods that have been used to identify metastasis suppressors and the potential clinical impact of these genes.
University of Washington Medical Center, Seattle, WA, USA. jyan@u.washington.edu
Jinchun
J
Yan
Qin
Q
Yang
Qihong
Q
Huang
D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D016147:Genes, Tumor Suppressor; D023281:Genomics; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis