Primary antiphospholipid syndrome and panhypopituitarism: a unique presentation.
Lymphocytic hypophysitis (LH) has been described previously in systemic lupus erythematosus (1.3%), Sjögren's syndrome (0.8%). Lymphocytic hypophysitis (LH) is rarely associated with rheumatic diseases, although three cases of pituitary disease associated with antiphospholipid syndrome (APS) have been described. Here, we report a possible association between APS and LH for the first time. A 34-yr-old woman with primary APS presented with polyuria, polydipsia, hypernatremia and impaired vision. Her hormone profile was compatible with panhypopituitarism, and sellar magnetic resonance imaging (MRI) depicted a normal pituitary gland with a thickened and displaced stalk and infundibulum portion. Hormone replacement was started, and the patient experienced a good clinical evolution.
Biomedicine, Universidade Cidade de São Paulo, São Paulo, SP, Brazil.
Bárbara Santos Pires
BS
da Silva
Camila
C
Bonin
Cristina Bellotti Formiga
CB
Bueno
Andrea
A
Glezer
Marcello D
MD
Bronstein
Jozélio Freire
JF
Carvalho
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000150:complications*