Folic acid-conjugated graphene oxide for cancer targeted chemo-photothermal therapy.
Nanographene oxide (NGO), a new type of nanomaterial for anticancer drugs delivery and near-infrared (NIR)-mediated photothermal ablation of tumors, has been used in the combination of photothermal therapy and chemotherapy. Herein, targeted chemo-photothermal therapy based on polyvinylpyrrolidone (PVP) functionalized NGO was achieved. Folic acid (FA), a common target molecule to cancer cells, was conjugated to NGO via covalent amide bond. The obtained FA-NGO-PVP was proved to be an ideal pH-responsive nanocarrier for delivery of an anticancer drug doxorubicin (DOX) with the loading ratio more than 100%. In vitro experiments were then performed with the combination of chemotherapy and NIR photothermal therapy. The results demonstrated that the targeted chemo-photothermal therapy could specifically deliver drug and heat to tumor sites and showed excellent efficacy of anticancer therapy. Thus, FA-NGO-PVP could be used as a novel nanomaterial for selective chemo-photothermal therapy.
MOE Key Laboratory of Laser Life Science & Laboratory of Photonic Chinese Medicine, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
X C
XC
Qin
Z Y
ZY
Guo
Z M
ZM
Liu
W
W
Zhang
M M
MM
Wan
B W
BW
Yang
D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D001692:Biological Transport; D004317:Doxorubicin / Q000737:chemistry / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D005492:Folic Acid / Q000737:chemistry* / Q000378:metabolism; D058972:Folic Acid Transporters / Q000378:metabolism; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D006358:Hot Temperature; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D010087:Oxides / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*
D000970:Antineoplastic Agents; D004337:Drug Carriers; D058972:Folic Acid Transporters; D010087:Oxides; D006108:Graphite; D004317:Doxorubicin; D005492:Folic Acid; D011205:Povidone