Synthesis and antitubercular activity of amino alcohol fused spirochromone conjugates.
A series of 21 new amino alcohol fused spirochromone conjugates have been synthesized, characterized with analytical data and evaluated their antimycobacterial activity against Mycobacterium tuberculosis (virulent strain H37Rv) in vitro. Some of the compounds exerted significant inhibition, in particular, compound 4f found to be the most potent derivative exhibiting MIC=3.13 μg/mL.
Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune 411 008, India.
M
M
Mujahid
R G
RG
Gonnade
P
P
Yogeeswari
D
D
Sriram
M
M
Muthukrishnan
D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002867:Chromones / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000605:Amino Alcohols; D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D002867:Chromones; D013141:Spiro Compounds