Drug release mechanisms of steroid eluting rings in cardiac pacemaker lead electrodes.
This paper reports on the drug release mechanisms of silicone structures with embedded steroids applied in pacing leads. Different derivatives of the steroid dexamethasone, which is associated with the reduction of acute stimulation thresholds, were evaluated together with different matrix based release control mechanisms with the target to potentially match optimal drug release rates during the first month after implantation. By incorporating dexamethasone-21-dihydrogen phosphate in silicone matrices in combination with release rate adaption layers, almost continuous release rates were obtained under physiological test settings.
Institut für Mikround Informationstechnik der Hahn-Schickard-Gesellschaft e.V. (HSG-IMIT), Villingen-Schwenningen, Germany. simon.herrlich@hsg-imit.de
Simon
S
Herrlich
Sven
S
Spieth
Hans
H
Gerstmann
Astrid
A
Virnich
Franz
F
Zipfel
Achim
A
Kitschmann
Thorsten
T
Goettsche
Peter
P
Osypka
Roland
R
Zengerle
D002851:Chromatography, High Pressure Liquid; D003907:Dexamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D004567:Electrodes, Implanted; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D010138:Pacemaker, Artificial; D012828:Silicones
D005938:Glucocorticoids; D012828:Silicones; C004180:dexamethasone 21-phosphate; D003907:Dexamethasone; C018038:dexamethasone acetate