Steroidal carboxylic acids from soft coral Paraminabea acronocephala.
Three new steroidal carboxylic acids, paraminabic acids A-C (1-3) were isolated from a Formosan soft coral Paraminabea acronocephala. The structures of these compounds were established by extensive spectroscopic analysis and chemical methods. Application of the PGME method allowed the establishment of the absolute configurations at C-25 and C-24 for 1 and 2, respectively. Compound 3 showed potent cytotoxicity toward Hep3B, MDA-MB-231, MCF-7, and A-549 cancer cell lines, with IC(50) values ranging from 2.05 to 2.83 μg/mL. Compounds 2 and 3 were found to inhibit the accumulation of the pro-inflammatory iNOS protein.
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. chaochihhua@hotmail.com
Chih-Hua
CH
Chao
Yang-Chang
YC
Wu
Zhi-Hong
ZH
Wen
Jyh-Horng
JH
Sheu
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D002264:Carboxylic Acids; D013256:Steroids; D052247:Nitric Oxide Synthase Type II