Middle ear effusion in patients with sinonasal cancer treated by surgery with or without radiotherapy.
OBJECTIVE
To identify the prevalence and risk factors of eustachian tube dysfunction after surgery for sinonasal cancer by observing the occurrence of middle ear effusion.


METHODS
Historical cohort study.


METHODS
Academic university hospital.


METHODS
Clinical records of 112 patients surgically treated for sinonasal cancer over a 16-year period were evaluated. Initial bivariate analysis was followed by a multivariate logistic regression model.


RESULTS
The best model included 2 variables: posterior extension of surgical resection (nasopharynx, soft palate, eustachian tube, pterygomaxillary fossa, parapharyngeal space) with an odds ratio of 5.662 (95% confidence interval [CI], 1.877-9.447) and postoperative radiotherapy with an odds ratio of 8.691 (95% CI, 4.187-13.194).


CONCLUSIONS
Despite the limited number of patients, the study gives a prediction of middle ear effusion based on 2 well-defined factors: surgical resection of anatomic structures involved in tubal function and adjuvant radiotherapy.
Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia School of Medicine, Brescia, Italy. redaelli@med.unibs.it
Luca Oscar
LO
Redaelli de Zinis
Giovanni
G
Parrinello
Alberto
A
Schreiber
Piero
P
Nicolai
D000368:Aged; D015331:Cohort Studies; D005064:Eustachian Tube / Q000293:injuries* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D010034:Otitis Media with Effusion / Q000209:etiology*; D013517:Otorhinolaryngologic Surgical Procedures / Q000009:adverse effects*; D010255:Paranasal Sinus Neoplasms / Q000532:radiotherapy / Q000601:surgery; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects*; D055815:Young Adult