The effect of Halofuginone in the amelioration of radiation induced-lung fibrosis.
The lung is one of the most sensitive organs to ionizing radiation, and damage to normal lung tissue remains a major dose limiting factor for patients receiving radiation to the thorax. Radiation induced lung injury (RILI) which is also named as "radiation pneumonpathy" is a continuous process and regarded as the result of an abnormal healing response. It has been shown that transforming growth factor β-1 (TGF-β1) plays an integral role in the radiation induced lung fibrosis formation by promoting the chemoattraction of fibroblasts and their conversion to myofibroblasts. Halofuginone is a, low molecular weight plant derived alkaloid, isolated from the Dichroa febrifuga plant that exhibits antifibrotic activity and inhibition of type I collagen synthesis. Halofuginone has been shown to protect against radiation induced soft tissue fibrosis by virtue of inhibiting various members of TFG-β signaling pathway. By the light of these findings, we hypothesize that Halofuginone may be able to ameliorate the radiation induced lung fibrosis.
Selcuk University, Faculty of Medicine, Department of Radiation Oncology, Konya, Turkey. guler.aydinyavas@gmail.com
Guler
G
Yavas
Mustafa
M
Calik
Goknil
G
Calik
Cagdas
C
Yavas
Ozlem
O
Ata
Hidir
H
Esme
D000818:Animals; D005355:Fibrosis / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D055370:Lung Injury / Q000188:drug therapy* / Q000378:metabolism*; D010880:Piperidines / Q000627:therapeutic use*; D052999:Quinazolinones / Q000627:therapeutic use*; D017564:Radiation Pneumonitis / Q000188:drug therapy* / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D010880:Piperidines; D052999:Quinazolinones; D011837:Radiation-Protective Agents; D016212:Transforming Growth Factor beta; C010176:halofuginone