Molecular basics of sepsis developement.
Bacterial infections and sepsis remain major causes of morbidity and  mortality in intensive care units. The normal host response to infection  is a complex process that serves to localise and control the invasion  of microbes and to repair injured tissue. Local inflammatory processes  are regulated through the production of cytokines by macrophages. In  some cases, mediator release exceeds the boundaries of the local  environment and results in the development of sepsis. It is well known  that the innate immune system plays a crucial role in preventing  microbial invasion. The human innate immune system consists of  genetically programmed defence mechanisms that are directed against  molecular components found only in microorganisms. Understanding the  complexity of early response to infection with respect to innate immune  response is required for the future development of drugs that will  effectively control infectious diseases.
Department of Anaesthesiology and Intensive Therapy, Medical University in Białystok, 15–276 Białystok, Poland. jedynaka@umwb.edu.pl
Monika
M
Jedynak
Andrzej
A
Siemiątkowski
Karolina
K
Rygasiewicz
D017209:Apoptosis; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000502:physiology; D018805:Sepsis / Q000276:immunology* / Q000382:microbiology; D015398:Signal Transduction
D018836:Inflammation Mediators