Atypical florid vascular proliferation in appendix: a diagnostic dilemma.
Vascular abnormality of the intestine is rare, except angiodysplasia. We report on an unusual case of atypical florid vascular proliferations of the appendix. A 41-year old male presented with melena. Adhesioned blood clots in the appendiceal orifice were observed by colonoscopy. He underwent laparoscopic appendectomy. Microscopically, a tiny exophytic polypoid mass was observed. The mass showed pyogenic granuloma-like features in the superficial portion and infiltrative florid vascular proliferations in the deeper portion. Endothelial cells showed minimal nuclear atypia, and mitotic figures were observed infrequently and showed positivity for CD31 and CD34 and negativity for HHV-8. Differential diagnoses include from benign vascular tumor to angiosarcoma or Kaposi's sarcoma, but this lesion does not fit the description of any defined vascular entity. We diagnosed atypical florid vascular proliferations and the patient has been well during the five-month postoperative follow-up.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1386921325843104.
Department of Pathology, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu, Rep of Korea. mjgu@yu.ac.kr
Mi Jin
MJ
Gu
Joon Hyuk
JH
Choi
So Hyun
SH
Kim
D000328:Adult; D001062:Appendectomy / Q000379:methods; D001065:Appendix / Q000098:blood supply* / Q000601:surgery; D015415:Biomarkers / Q000032:analysis; D002429:Cecal Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D049109:Cell Proliferation; D003113:Colonoscopy; D003937:Diagnosis, Differential; D042783:Endothelial Cells / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D010535:Laparoscopy; D008297:Male; D008551:Melena / Q000209:etiology; D009389:Neovascularization, Pathologic; D011237:Predictive Value of Tests; D016896:Treatment Outcome
D015415:Biomarkers