[Expression and significance of pericytes and TGF-β in infantile parotid hemangioma].
OBJECTIVE
To study the expression and significance of pericytes and TGF-β in infantile parotid hemangioma.


METHODS
The expressions of pericytes and TGF-β at protein level were examined in 76 cases of infant parotid hemangioma by strep avidin-biotin complex (SABC) immunohistochemical technique. All statistical analysis were performed using SPSS 13.0 statistical package. The relationship between the expression of pericytes and TGF-β and clinical phase of hemangioma was analyzed by using Chi-square test. Kappa test was used to determine the relationship between pericytes and TGF-β expression.


RESULTS
The rates of positive expression of pericytes were 86.7%(13/15), 45.5%(10/22) and 51.3%(20/39) in early, middle and advanced stage of hemangioma,  respectively. The rates of positive expression of TGF-β were 33.3%(5/15), 40.9%(9/22) and 76.9%(30/39) in early, middle and advanced stage of hemangioma, respectively. There was significantly close correlation between the level of pericytes and clinical phase of hemangioma, as well as between TGF-β expression and clinical phase of hemangioma(P<0.05).


CONCLUSIONS
Pericytes and TGF-β may significantly contribute to the proliferation of infantile parotid hemangioma.
Department of Oral and Maxillofacial Surgery, Shengjing Hospital, China Medical University. Shenyang 110004, Liaoning Province, China. 86897405@qq.com
Xue
X
Meng
Cui-sha
CS
Deng
Qiu-xu
QX
Wang
Tian-xiang
TX
Wang
Wei-xian
WX
Liu
D006391:Hemangioma; D006801:Humans; D007223:Infant; D010306:Parotid Gland; D010307:Parotid Neoplasms; D020286:Pericytes; D016212:Transforming Growth Factor beta
D016212:Transforming Growth Factor beta