Synthesis of 3,5-disubstituted pyrazoles via Cope-type hydroamination of 1,3-dialkynes.
An efficient method for the synthesis of 3,5-disubstituted pyrazoles is described. The reactions of 1,3-dialkynes with hydrazine proceeded smoothly in dimethyl sulfoxide under mild reaction conditions to produce 3,5-disubstituted pyrazoles in satisfactory to excellent yields. A one-pot procedure of the transformation has been developed.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.
Liangguang
L
Wang
Xiaoqiang
X
Yu
Xiujuan
X
Feng
Ming
M
Bao
D000480:Alkynes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D011720:Pyrazoles