Structure-function relationships of postnatal tendon development: a parallel to healing.
This review highlights recent research on structure-function relationships in tendon and comments on the parallels between development and healing. The processes of tendon development and collagen fibrillogenesis are reviewed, but due to the abundance of information in this field, this work focuses primarily on characterizing the mechanical behavior of mature and developing tendon, and how the latter parallels healing tendon. The role that extracellular matrix components, mainly collagen, proteoglycans, and collagen cross-links, play in determining the mechanical behavior of tendon will be examined in this review. Specifically, collagen fiber re-alignment and collagen fibril uncrimping relate mechanical behavior to structural alterations during development and during healing. Finally, attention is paid to a number of recent efforts to augment injured tendon and how future efforts could focus on recreating the important structure-function relationships reviewed here.
McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA.
Brianne K
BK
Connizzo
Sarah M
SM
Yannascoli
Louis J
LJ
Soslowsky
D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D011509:Proteoglycans / Q000378:metabolism; D013329:Structure-Activity Relationship; D013708:Tendon Injuries / Q000378:metabolism* / Q000503:physiopathology; D013710:Tendons / Q000254:growth & development* / Q000503:physiopathology; D023822:Tissue Engineering; D014945:Wound Healing / Q000502:physiology
D011509:Proteoglycans