Anti-inflammatory lignans from the fruits of Acanthopanax sessiliflorus.
A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA, Eumseong, Korea.
Dae-Young
DY
Lee
Kyeong-Hwa
KH
Seo
Rak-Hun
RH
Jeong
Sang-Min
SM
Lee
Geum-Soog
GS
Kim
Hyung-Jun
HJ
Noh
Seung-Yu
SY
Kim
Gye-Won
GW
Kim
Ji-Young
JY
Kim
Nam-In
NI
Baek
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D028001:Eleutherococcus / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000494:pharmacology*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D017705:Lignans; D008070:Lipopolysaccharides; D010936:Plant Extracts; C581494:acanthosessilin A; D009569:Nitric Oxide