[Denervation change of tensor veli palati in obstructive sleep apnea hypopnea syndrome].
OBJECTIVE
To explore the denervation change of Tensor Veli Palati in patients with OSAHS by determine the mRNA and protein expression of NCAM.


METHODS
The OSAHS group was consisted of 30 OSAHS patients and the normal control group was consisted of 10 chronic tonsillitis patients without OSAHS. Real-time quantitative RT-PCR and Western blot methods were used to determine the NCAM expression in specimens.


RESULTS
(1) The mRNA and protein expression level of NCAM in the OSAHS group increased significantly compared with that in control group (P < 0.05). (2) There was positive correlation between AHI and the protein expression level of NCAM in the OSAHS group (r = 0.803, P < 0.01).


CONCLUSIONS
These results indicate that the denervation change of tensor veli palati appear in OSAHS patients, and the severity of OSAHS are relevant with the degree of denervation.
Department of Otolaryngology-Head and Neck Surgery, Fuzhou General Hospital of PLA, Nanjing Military Region, Fuzhou, 350025, China.
Yifang
Y
Yang
Xian
X
Zhang
Xianming
X
Chen
D000328:Adult; D016022:Case-Control Studies; D003714:Denervation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010156:Palatal Muscles / Q000294:innervation*; D020181:Sleep Apnea, Obstructive / Q000378:metabolism*; D055815:Young Adult