Dependence of simulated positron emitter yields in ion beam cancer therapy on modeling nuclear fragmentation.
In ion beam cancer therapy, range verification in patients using positron emission tomography (PET) requires the comparison of measured with simulated positron emitter yields. We found that (1) changes in modeling nuclear interactions strongly affected the positron emitter yields and that (2) Monte Carlo simulations with SHIELD-HIT10Areasonably matched the most abundant PET isotopes (11)C and (15)O. We observed an ion-energy (i.e., depth) dependence of the agreement between SHIELD-HIT10Aand measurement. Improved modeling requires more accurate measurements of cross-section values.
Department of Physics and Astronomy, University of Aarhus, Aarhus, Denmark; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark; OncoRay-National Center for Radiation Research in Oncology, Technical University Dresden, Dresden, Germany. Electronic address: luehr@phys.au.dk.
Armin
A
Lühr
Marlen
M
Priegnitz
Fine
F
Fiedler
Nikolai
N
Sobolevsky
Niels
N
Bassler
D004583:Electrons; D006801:Humans; D009010:Monte Carlo Method; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D049268:Positron-Emission Tomography
Ion beam cancer therapy; Monte Carlo simulation; Nuclear fragmentation; PET nuclides; SHIELD-HIT10A