[Comparative study on Chinese medical syndrome typing and treatment combined different surgical methods for treating clomiphene-resistant polycystic ovary syndrome].
OBJECTIVE
To observe the therapeutic efficacy of Chinese medical syndrome typing and treatment combined cold needle puncture drainage operation or unipolar electrocoagulation drilling technique under laparoscope for treating clomiphene-resistant polycystic ovary syndrome (PCOS).


METHODS
Forty infertility patients with clomiphene-resistant PCOS were assigned to two groups using stratified random sampling method according to age, infertility time, and body mass index, 20 in each group. Patients in Group A were treated with Chinese medical syndrome typing and treatment combined cold needle puncture drainage operation, while those in Group B were treated with Chinese medical syndrome typing and treatment combined unipolar electrocoagulation drilling technique. After operation Chinese herbal treatment was administered to all patients according to syndrome typing. The serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), androgen (T), estradiol (E2), and prolactin (PRL) were determined before and after operation. The ovulation was monitored. The pregnancy rate and the pregnancy outcomes were recorded after operation.


RESULTS
There was no statistical difference in the 3-month spontaneous ovulation rate or the 1-year pregnancy rate (P > 0.05). The levels of LH, T, and PRL were significantly lower after operation than before operation in the two groups (P < 0.05). The menstruation and ovulation were obviously improved after operation. The total ovulation rate was 95% (19/20) in Group A. Successful pregnancy occurred in 15 cases of Group A. Ovarian hyperstimulation syndrome (OHSS) occurred in 1 case of Group A. The total ovulation rate was 90% (18/20) in Group B. Successful pregnancy occurred in 13 cases of Group B. Hypovaria occurred in 1 case of Group B. Luteinized unruptured follicle (LUFS) occurred in 2 cases of Group A and 1 case of Group B.


CONCLUSIONS
Chinese medical syndrome typing and treatment combined cold needle puncture drainage operation or unipolar electrocoagulation drilling technique could effectively promote the ovulation. The two methods showed similar therapeutic effects.
Department of Gynecology, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou. winnalei@hotmail.com
Lei
L
Zeng
Cheng
C
Zeng
Li-Li
LL
Tao
D000328:Adult; D002996:Clomiphene / Q000494:pharmacology; D004351:Drug Resistance; D004564:Electrocoagulation; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis; D006801:Humans; D055048:Integrative Medicine; D010535:Laparoscopy; D007986:Luteinizing Hormone / Q000032:analysis; D008516:Medicine, Chinese Traditional / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000628:therapy*; D011247:Pregnancy; D011388:Prolactin / Q000032:analysis
D002996:Clomiphene; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone