Visualization of UV-induced damage on single DNA molecules.
Ultraviolet radiation induced DNA damage such as double stranded breaks and single stranded breaks is visualized at the level of single DNA molecules. Molecular observations provide a map of DNA radiation-mediated breakages, revealing the sequence dependency of DNA damage rather than random occurrences.
Department of Chemistry and Interdisciplinary Program of Integrated Biotechnology, Sogang University, Seoul 121-742, Korea.
Jinyong
J
Lee
Hyun Seung
HS
Park
Sangyong
S
Lim
Kyubong
K
Jo
D001583:Benzoxazoles; D002232:Carbocyanines; D004247:DNA / Q000378:metabolism / Q000528:radiation effects*; D053960:DNA Breaks; D045647:DNA Glycosylases / Q000378:metabolism; D005456:Fluorescent Dyes; D008856:Microscopy, Fluorescence; D011806:Quinolinium Compounds; D014466:Ultraviolet Rays / Q000009:adverse effects*
C569686:Alexa Fluor 647; D001583:Benzoxazoles; D002232:Carbocyanines; D005456:Fluorescent Dyes; D011806:Quinolinium Compounds; C075296:1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidene)quinolinium; D004247:DNA; D045647:DNA Glycosylases; C036401:deoxyribopyrimidine endonucleosidase