Copper-catalyzed enantioselective allyl-allyl cross-coupling.
A Cu(I)-phosphoramidite-based catalytic system that allows asymmetric allyl-allyl cross-coupling with high enantioselectivity is reported. This transformation tolerates a large variety of functionalized substrates. The versatility of this new reaction is illustrated in the catalytic asymmetric synthesis of the Martinelline alkaloids chromene derivative core.
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Valentín
V
Hornillos
Manuel
M
Pérez
Martín
M
Fañanás-Mastral
Ben L
BL
Feringa
D000498:Allyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000498:Allyl Compounds; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D003300:Copper