Adjuvant activity of Sargassum pallidum polysaccharides against combined Newcastle disease, infectious bronchitis and avian influenza inactivated vaccines.
This study evaluates the effects of Sargassum pallidum polysaccharides (SPP) on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND), infectious bronchitis (IB) and avian influenza (AI) was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis.
School of Medicinal and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China. lilijielinxi@126.com
Li-Jie
LJ
Li
Ming-Yi
MY
Li
Yan-Tuan
YT
Li
Jing-Jing
JJ
Feng
Feng-Qiang
FQ
Hao
Zhang
Z
Lun
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D049109:Cell Proliferation; D002645:Chickens; D018352:Coronavirus Infections / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D001351:Infectious bronchitis virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology; D005585:Influenza in Birds / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D009521:Newcastle Disease / Q000276:immunology; D009522:Newcastle disease virus / Q000276:immunology; D011134:Polysaccharides / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D044647:Sargassum / Q000737:chemistry*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000276:Adjuvants, Immunologic; D007252:Influenza Vaccines; D011134:Polysaccharides; D014765:Viral Vaccines