The immunological basis of degenerative diseases of the eye.
It has become clear that disorders that were once considered "degenerative" have complex mechanisms, with many having been shown to have immune mediation as part of the disease process. These include arteriosclerotic heart disease and Alzheimer's disease. Indeed, several ocular disorders that once fell into the "degenerative" category meet this criterion as well. Immune mediation has been shown to be a part of many of the most common ocular disorders, and not just that of uveitis, or ocular inflammatory disease.
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20814, USA. DrBob@nei.nih.gov
Robert B
RB
Nussenblatt
Baoying
B
Liu
Lai
L
Wei
H Nida
HN
Sen
D000544:Alzheimer Disease / Q000276:immunology*; D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D050379:Arteriolosclerosis / Q000276:immunology*; D015551:Autoimmunity; D016570:Bruch Membrane / Q000276:immunology / Q000473:pathology; D015785:Eye Diseases, Hereditary / Q000276:immunology*; D006801:Humans; D000069579:Ranibizumab; D012162:Retinal Degeneration / Q000276:immunology* / Q000628:therapy; D015593:Retinal Drusen / Q000276:immunology*; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology
D061067:Antibodies, Monoclonal, Humanized; D042461:Vascular Endothelial Growth Factor A; D000069579:Ranibizumab