Treating chronic myeloid leukemia: improving management through understanding of the patient experience.
The tremendous progress made in chronic myeloid leukemia (CML) treatment affords patients more options than ever. Five currently available BCR-ABL inhibitors form the mainstay of CML treatment, including first-generation imatinib and more potent second-generation BCR-ABL inhibitors dasatinib and nilotinib, with bosutinib and ponatinib having been recently approved for market inclusion. Studies show that dasatinib and nilotinib exhibit greater efficacy than imatinib in first-line chronic-phase CML (CML-CP), allowing more patients to achieve deeper, more rapid responses associated with improved outcomes. With alternatives to imatinib for first-line CML-CP and the wealth of information (and misinformation) on the Internet, a tremendous need exists for clear, accurate facts to assist patients in making treatment decisions. Patients appreciate the guidance of their oncology nurse in providing disease, treatment, and monitoring information tailored to meet their needs. Oncology nurses who are able to clearly explain emerging data, including the meaning and significance of faster, deeper responses, will be a valuable resource to their patients.
Chronic Myeloid Leukemia Society of Canada in Beconsfield, Quebec, Canada. cheryl.simoneau@cmlsociety.org
Cheryl-Anne
CA
Simoneau
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000600:supply & distribution / Q000627:therapeutic use*; D001549:Benzamides / Q000009:adverse effects / Q000600:supply & distribution / Q000627:therapeutic use; D000069439:Dasatinib; D016044:Fusion Proteins, bcr-abl / Q000037:antagonists & inhibitors; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000523:psychology; D008019:Life Style; D010349:Patient Compliance; D010353:Patient Education as Topic; D010879:Piperazines / Q000009:adverse effects / Q000600:supply & distribution / Q000627:therapeutic use; D011743:Pyrimidines / Q000009:adverse effects / Q000600:supply & distribution / Q000627:therapeutic use; D011788:Quality of Life; D013844:Thiazoles / Q000009:adverse effects / Q000600:supply & distribution / Q000627:therapeutic use
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D013844:Thiazoles; D000068877:Imatinib Mesylate; D016044:Fusion Proteins, bcr-abl; D000069439:Dasatinib