Signal transduction on enzymes: the effect of electromagnetic field stimuli on superoxide dismutase (SOD).
Protein functions and characteristics can highly differ from physiological conditions in presence of chemical, mechanical or electromagnetic stimuli. In this work we provide a rigorous picture of electric field effects on proteins behavior investigating, at atomistic details, the possible ways in which an external signal can be transduced into biochemical effects. Results from molecular dynamics (MD) simulations of a single superoxidismutase (SOD) enzyme in presence of high exogenous alternate electric fields will be discussed.
Department of Information Engineering, Electronics and Telecomunications. marracino@die.uniroma1.it
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Marracino
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Migliorati
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Paffi
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Denzi
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d'Inzeo
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Apollonio
D004574:Electromagnetic Fields; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D015398:Signal Transduction; D013482:Superoxide Dismutase / Q000737:chemistry*
D013482:Superoxide Dismutase