Effects of casein phosphopeptide-amorphous calcium phosphate remineralizing paste and 8% arginine desensitizing paste on dentin permeability.
OBJECTIVE
To compare the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste and 8% arginine paste on dentin permeability.


METHODS
Sixteen human third molars were sectioned to remove the roots and expose occlusal dentin surfaces. The pulpal side was flattened to obtain 1 mm remaining dentin thickness. Each specimen was attached on a Perspex plate and connected to a dentin-permeability measuring apparatus. The specimens were divided into two groups according to the tested products. Dentin permeability was measured under a simulated pulpal pressure after: (a) etching with 37% phosphoric acid; (b) application of CPP-ACP or 8% arginine paste; and (c) acid challenge with 2.6 mmol/L lactic acid. Twelve specimens were prepared so that the treated dentin surfaces could be examined using a scanning electron microscope.


RESULTS
Dentin permeability after the application of 8% arginine paste was significantly reduced and lower than that of CPP-ACP paste (P < 0.01). Acid challenge with lactic acid significantly increased dentin permeability in both experimental groups (P < 0.01). The dentin surface treated with 8% arginine paste was covered with particles, but they were removed by acid challenge. Most dentinal tubules were patent when the CPP-ACP paste was applied.


CONCLUSIONS
The application of 8% arginine paste decreased dentin permeability, but CPP-ACP paste did not.
Department of Operative Dentistry and Endodontics, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. dtdby@mahidol.ac.th
Danuchit
D
Banomyong
Panassaya
P
Kanchanasantikul
Rebecca H
RH
Wong
D001120:Arginine / Q000494:pharmacology*; D002119:Calcium Carbonate / Q000494:pharmacology; D002364:Caseins / Q000494:pharmacology*; D003804:Dentin / Q000187:drug effects / Q000648:ultrastructure; D057133:Dentin Desensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D003806:Dentin Permeability / Q000187:drug effects*; D006801:Humans; D019344:Lactic Acid / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning
D002364:Caseins; D057133:Dentin Desensitizing Agents; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D019344:Lactic Acid; D001120:Arginine; D002119:Calcium Carbonate
arginine; casein phosphopeptide-amorphous calcium phosphate; dentin permeability; desensitizer; remineralizing