Hydrolytic and aminolytic kinetic resolution of terminal bis-epoxides.
Hydrolytic and aminolytic kinetic resolution of terminal bis-epoxides catalyzed by (salen)Co(III) complexes affords epoxy-diols and N-protected epoxy-amino alcohols with excellent enantio- and diastereoselectivity and good yields. An operationally simple procedure gives instant access to valuable building blocks containing two remote stereocenters in highly enantioenriched form.
Institute of Technology, University of Tartu, Nooruse 1, 50411, Tartu, Estonia.
Jevgenia
J
Bredihhina
Piret
P
Villo
Kārlis
K
Andersons
Lauri
L
Toom
Lauri
L
Vares
D000605:Amino Alcohols / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D013237:Stereoisomerism
D000605:Amino Alcohols; D004852:Epoxy Compounds; D003035:Cobalt