Can a gene-expression classifier with high negative predictive value solve the indeterminate thyroid fine-needle aspiration dilemma?
The recent study by Alexander et al validates the effectiveness of the Afirma test, and suggests a potential ancillary role for this unique test when appropriately applied in the evaluation of thyroid nodules classified by fine-needle aspiration as indeterminate.
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. wfaquin@partners.org
William C
WC
Faquin
D014408:Biomarkers, Tumor / Q000235:genetics*; D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000145:classification* / Q000175:diagnosis / Q000235:genetics; D016606:Thyroid Nodule / Q000145:classification* / Q000175:diagnosis / Q000235:genetics
D014408:Biomarkers, Tumor