Iodide as an activating agent for acid chlorides in acylation reactions.
Acid chlorides can be activated using a simple iodide source to undergo nucleophilic attack from a variety of relatively weak nucleophiles. These include Friedel-Crafts acylation of N-methylpyrroles, N-acylation of sulfonamides, and acylation reactions of hindered phenol derivatives. The reaction is believed to proceed through a transient acid iodide intermediate.
Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom.
Russell J
RJ
Wakeham
James E
JE
Taylor
Steven D
SD
Bull
James A
JA
Morris
Jonathan M J
JM
Williams