Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents.
BACKGROUND
The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular interest.


METHODS
This study is focused on propargyl acetate derivatives. Eight molecules were designed based on propargyl alcohols and different acid anhydrides.


RESULTS
All the synthesized compounds and commercially available ones were evaluated for anti-tuberculosis activity.


CONCLUSIONS
Inhibitors against Mtb have been identified and characterized for further development into potential novel anti-tubercular drugs.
Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute, Tehran, Iran 13164. ssardari@hotmail.com.
Parisa
P
Azerang
Ali Hossein
AH
Rezayan
Soroush
S
Sardari
Farzad
F
Kobarfard
Mitra
M
Bayat
Kimia
K
Tabib