Synthesis and antibacterial evaluation of novel heterocyclic compounds containing a sulfonamido moiety.
Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of active methylene compounds producing pyran, pyridine and pyridazine derivatives. Also, the reactivity of the precursor hydrazone towards hydrazine derivatives to give pyrazole and oxazole derivatives was studied. On the other hand, treatment of the same precursor with urea, thiourea and/or guanidine hydrochloride furnished pyrimidine and thiazine derivatives, respectively. The newly synthesized compounds were tested for antibacterial activity, whereby eight compounds were found to have high activities.
Organic Synthetic Lab, Chemistry Department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt.
Mohammad Emad
ME
Azab
Mohamed M
MM
Youssef
Eman A
EA
El-Bordany
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects; D003500:Cyclization; D052978:Disk Diffusion Antimicrobial Tests; D009570:Nitriles; D010080:Oxazoles / Q000138:chemical synthesis / Q000494:pharmacology; D011513:Proteus mirabilis / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D012706:Serratia marcescens / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009570:Nitriles; D010080:Oxazoles; D011720:Pyrazoles; D011724:Pyridazines; D011743:Pyrimidines; D013449:Sulfonamides