Changes in the blood flow of the femoral artery by botulinum toxin A in rats.
We examined the changes in blood flow in the femoral artery caused by botulinum toxin A in rats. Blood flow was measured using laser Doppler flowmetry. We used male Sprague-Dawley-derived rats weighing between 350 and 400 g. The study was performed on 6 groups; each of them consisted of 30 rats (control and botulinum toxin A 0.5, 1, 2, 4, and 8 units). The laser Doppler flowmetry revealed that blood flow in the femoral artery increased by the third day in the groups injected with 1 or more units of botulinum toxin A. In the groups injected with 8 units of botulinum toxin A, we recognized an increase of blood flow from the second day. Our results suggest that botulinum toxin A is concerned in improving blood flow.
From the Department of Plastic and Reconstructive Surgery, School of Medicine, Showa University, Tokyo, Japan.
Minoru
M
Hayashi
Yuki
Y
Shimizu
Masahide
M
Sato
Toshiya
T
Yokoyama
Shinya
S
Yosimoto
D065087:Acetylcholine Release Inhibitors / Q000494:pharmacology*; D000818:Animals; D019274:Botulinum Toxins, Type A / Q000494:pharmacology*; D005263:Femoral Artery / Q000502:physiology*; D017078:Laser-Doppler Flowmetry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects*
D065087:Acetylcholine Release Inhibitors; D019274:Botulinum Toxins, Type A; C545476:incobotulinumtoxinA