The mitochondrion: a perpetrator of acquired hearing loss.
Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably less information available as to the mechanisms underlying ROS formation. Most cellular ROS arise in mitochondria and this review will evaluate evidence for mitochondrial pathology in general and dysfunction of the mitochondrial respiratory chain in particular in acquired hearing loss. We will discuss evidence that different pathways can lead to the generation of ROS and that oxidative stress might not necessarily be causal to all three pathologies. Finally, we will detail recent advances in exploiting knowledge of aminoglycoside-mitochondria interactions for the development of non-ototoxic antibacterials. This article is part of a Special Issue entitled "Annual Reviews 2013".
Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland.
Erik C
EC
Böttger
Jochen
J
Schacht
D000617:Aminoglycosides / Q000009:adverse effects / Q000737:chemistry; D000818:Animals; D016923:Cell Death; D004272:DNA, Mitochondrial / Q000235:genetics; D004579:Electron Transport; D004734:Energy Metabolism / Q000187:drug effects; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D034381:Hearing Loss / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D006317:Hearing Loss, Noise-Induced / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009154:Mutation; D011304:Presbycusis / Q000378:metabolism / Q000473:pathology; D012335:RNA, Ribosomal / Q000235:genetics; D017382:Reactive Oxygen Species / Q000378:metabolism
D000617:Aminoglycosides; D004272:DNA, Mitochondrial; D012335:RNA, Ribosomal; D017382:Reactive Oxygen Species
ROS; SOD; mitochondrial DNA; mtDNA; rRNA; reactive oxygen species; ribosomal RNA; superoxide dismutase