Potential of urinary metabolites for diagnosing multiple sclerosis.
A definitive diagnostic test for multiple sclerosis (MS) does not exist; instead physicians use a combination of medical history, magnetic resonance imaging, and cerebrospinal fluid analysis (CSF). Significant effort has been employed to identify biomarkers from CSF to facilitate MS diagnosis; however, none of the proposed biomarkers have been successful to date. Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Nevertheless, urinary metabolites have not been extensively explored as a source of biomarkers for MS. We demonstrate that urinary metabolites have significant promise for monitoring disease-progression, and response to treatment in MS patients. NMR analysis of urine permitted the identification of metabolites that differentiate experimental autoimmune encephalomyelitis (EAE)-mice (prototypic disease model for MS) from healthy and MS drug-treated EAE mice.
Teklab
T
Gebregiworgis
Chandirasegaran
C
Massilamany
Arunakumar
A
Gangaplara
Sivasubramani
S
Thulasingam
Venkata
V
Kolli
Mark T
MT
Werth
Eric D
ED
Dodds
David
D
Steffen
Jay
J
Reddy
Robert
R
Powers
D000595:Amino Acid Sequence; D000818:Animals; D015415:Biomarkers / Q000652:urine*; D004195:Disease Models, Animal; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000652:urine
D015415:Biomarkers