Continuous C-peptide loss in patients with type 1 diabetes and multiethnic background.
C peptide (CP) was evaluated in 88 individuals with type 1 diabetes, variable disease duration and multiethnic background. Initially, 28 patients had detectable CP, which persisted in 46.2% after 17.4±4 months. CP decline was associated with ethnicity, HbA1c and baseline CP, but not with GADA, PTPN22 or insulin gene polymorphisms.
Nutrology Department, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (HUCFF), Rio de Janeiro, RJ, Brazil. joanardantasp@ig.com.br
Joana R
JR
Dantas
Mirella H
MH
Almeida
Bianca
B
Barone
Fabiano
F
Serfaty
Luis R
LR
Raggio
Rosane
R
Kupfer
Lenita
L
Zajdenverg
José E P
JE
Oliveira
Melanie
M
Rodacki
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D044383:Black People; D002096:C-Peptide / Q000378:metabolism*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology* / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000235:genetics; D008297:Male; D044465:White People
D002096:C-Peptide; D006442:Glycated Hemoglobin; D007328:Insulin; C517652:hemoglobin A1c protein, human