[Preventive effect of plant cercaricide Fangyouling for schistosome infection].
OBJECTIVE
To evaluate the preventive effect of Fangyouling (a plant cercaricide) for schistosome infection in the field.


METHODS
Villagers contacting schistosome infested water in 3 administrative villages in Hubei Province were randomly selected, and the villagers rubbing Fangyouling before they contacted with the infested water were divided into Group I (159 cases) and those not rubbing Fangyouling before they contacted with the infested water were divided into Group II (172 persons). All the villagers were investigated by questionnaire, and their infections of schistosome were tested by sera and fecal examinations.


RESULTS
There were no differences of constituent ratios of gender, age, occupation, time and type of infested water contact between the two groups (all P values > 0.05). The positive rates of sera and fecal examinations were 3.14% and 1.87%, respectively in Group I , and the positive rates of sera and fecal examinations were 9.30% and 6.40%, respectively in Group II, and there were significant differences between both the results of sera and fecal examinations of Group I and Group II (both P values < 0.05). In Group I , there were 110 people who completely embrocated Fangyouling, and their positive rates of sera and fecal examinations were 0.91% and 0, respectively. There are 42 people who incompletely embrocated Fangyouling, and their positive rates of sera and fecal examinations were 8.16% and 6.12%, respectively, and there were significant differences (both P values < 0.05).


CONCLUSIONS
The preventive effect of schistosome infection of Fangyouling is significant. Incomplete embrocating may be one of the possible reasons for people still being infected with schistosome after rubbing the protective agent.
School of Public Health, Wuhan University, Wuhan 430072, China.
Sheng-Xian
SX
Wang
Jia-Min
JM
Shi
Mu-Minm
MM
Cao
Ling-Feng
LF
Dai
Yu-Hai
YH
Dai
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000818:Animals; D002417:Cattle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage*; D020011:Protective Agents / Q000008:administration & dosage*; D012547:Schistosoma / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology; D012552:Schistosomiasis / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control*; D012556:Schistosomicides / Q000008:administration & dosage*; D055815:Young Adult
D010936:Plant Extracts; D020011:Protective Agents; D012556:Schistosomicides