The atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratio.
The aim of this study was to evaluate the effect of consuming gilthead sea bream fillets, with different n-6/ n-3 ratios, on atherosclerotic biomarkers. Twenty healthy subjects were included in a randomised single-blinded cross-over trial. Participants were randomized into 2 groups, both of which received approximately 630 g per week of gilthead sea bream fed with either 100% fishmeal (FM) or partial replacement with plant proteins (PP) over two consecutive 10 week periods, respectively. Group A consumed firstly the FM fillets followed by the PP fillets, whereas the reverse order was adopted for group B. Group A reported a significant decrease of 29.3% (Δ = -26 mg/dL) in total cholesterol after the first phase of the intervention, before returning to baseline levels after the dietary intervention with fish fed with PP. Similarly, in group A, both LDL-cholesterol and triglycerides decreased significantly by 21.6% (Δ = -19 mg/dL) and 11.7% (Δ = -10.7 mg/dL), respectively, before increasing again after the intervention. Improvements in the inflammatory cytokines, interleukin-6 and -8 were also noted. Moreover, whole blood viscosity appeared significantly improved in group A, as seen by a significant increase of 7.59% (Δ = +4.59 mPA) for erythrocyte filtration rate. In conclusion, similar EPA+DHA content with different n- 6/n-3 ratio fish flesh intake was shown to have varied affects on lipid, inflammatory and haemorheological parameters in a group of healthy subjects.
Department of Clinica and Experimental Medicine, Thrombosis Centre, Florence, Italy. francescosofi@gmail.com
Francesco
F
Sofi
Gianluca
G
Giorgi
Francesca
F
Cesari
Anna Maria
AM
Gori
Lucia
L
Mannini
Giuliana
G
Parisi
Alessandro
A
Casini
Rosanna
R
Abbate
Gian Franco
GF
Gensini
Bianca Maria
BM
Poli
D000328:Adult; D000368:Aged; D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000503:physiopathology; D008078:Cholesterol, LDL / Q000097:blood; D018592:Cross-Over Studies; D004032:Diet; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000097:blood*; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000097:blood*; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage; D005399:Fishes; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016037:Single-Blind Method; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D008078:Cholesterol, LDL; D043371:Fatty Acids, Omega-6; D005395:Fish Oils; D015850:Interleukin-6; D016209:Interleukin-8; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid