[Quantitative analysis of individual groups of microorganisms, extracted from atherosclerotic lesions in the coronary arteries in patients depending upon ASP299GLY polymorphism of TLR4 gene].
The estimation data of contamination by separate groups of microorganisms and dependence of the microbial content level upon TLR4 gene 896A/G polymorphism in 20 samples of atherosclerotic lesions in coronary arteries has been presented. The presence of TLR4 gene polymorphic allele G in the individual genotype determines the increased contamination of atherosclerotic plaque tissues by the representatives of the following genera: Lactobacillus sp., Enterobacterium sp., Sneathia sp./Leptotrihia sp./Fusobacterium sp., Mobiluncus sp./Corynebacterium sp., Peptostreptococcus sp. The emergence of new correlation pairs with participation of Lachnobacterium sp./Corynebacterium sp. among the carriers of G allele has been revealed via the intragroup correlation analysis. The obtained results confirm the possible involvement of the represented groups of microorganisms in the pathogenesis of atherosclerosis and the role of the TLR4 gene polymorphic variant G in the increased microbial contamination of the coronary arteries tissues.
O V
OV
Skochko
L É
LÉ
Vesnina
N A
NA
Bobrova
O A
OA
Shlykova
T V
TV
Mamontova
O V
OV
Izmaĭlova
I P
IP
Kaĭdashev
D000483:Alleles; D050197:Atherosclerosis / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D001344:Autopsy; D003331:Coronary Vessels / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006090:Gram-Negative Bacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006094:Gram-Positive Bacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D058226:Plaque, Atherosclerotic / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D051197:Toll-Like Receptor 4 / Q000235:genetics*
C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4