Effect of gadobutrol on VX2 magnetic resonance diffusion-weighted imaging.
The aim of this study was to evaluate the effect of contrast agent gadobutrol on the magnetic resonance diffusion-weighted imaging (MR DWI). Gadobutrol has higher relaxivity than Gd-DTPA and it also has higher formulation 1.0 M than Gd-DTPA 0.5 M. VX2 tumor implanted on the left thigh of each New Zealand rabbit was used as the animal model. The MR scanning was performed using a 1.5 T clinical whole-body MR scanner with an 8-channel knee coil. The results showed that there were significant differences in the signal-to-noise ratio (SNR) and apparent diffusion coefficient (ADC) values between tumor and muscle both before and after gadobutrol injection (0.1 mmol/kg). However, there were no significant differences in the SNR and ADC values of tumor or muscle before and after gadobutol administration. There were also no significant difference in the contrast-to-noise ratio (CNR) values of tumor and muscle before and after gadobutrol injection.
Department of Biomedical Engineering, I-SHOU University, Kaohsiung 824, Taiwan, ROC. pcchen@isu.kmu.edu.tw
P-C
PC
Chen
J-C
JC
Jao
D-J
DJ
Lin
C-C
CC
Hsiao
H-B
HB
Pan
D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging; D009369:Neoplasms / Q000000981:diagnostic imaging*; D009942:Organometallic Compounds / Q000494:pharmacology*; D011817:Rabbits; D011859:Radiography; D059629:Signal-To-Noise Ratio
D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol