[The estimation method of compounds opiate activity based on universal three-dimensional model of the nonselective opiate pharmacophore].
Created by means alternative strategy of structural similarity search universal three-dimensional model of the nonselective opiate pharmacophore and the estimation method of agonistic and antagonistic properties of opiate receptors ligands based on its were described. The examples of the present method use are given for opiate activity estimation of compounds essentially distinguished on the structure from opiates and traditional opioids.
N E
NE
Kuz'mina
V A
VA
Iashkir
V A
VA
Merkulov
E S
ES
Osipova
D000701:Analgesics, Opioid / Q000737:chemistry*; D006801:Humans; D056004:Molecular Dynamics Simulation; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000701:Analgesics, Opioid