Establishment of a Korea HPV cohort study.
We have designed a five-year multicentre prospective cohort study in women who are both human papillomavirus (HPV)-positive with either atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) of cervix. This study aimed to analyze the risk of developing a high-grade squamous intraepithelial lesion (HSIL) from either ASCUS or LSIL in HPV-positive women, so called 'progression' rate, to investigate differences in the progression rates according to HPV type-specific infection, and to evaluate the various factors associated with the persistence or clearance of HPV infection in the Korean population. At present, the study protocol composed of cervical cytology, HPV DNA testing, and questionnaire have been conducted actively since the first participant was enrolled in 2010. This study is the first nationwide Korea HPV cohort study. Our data will provide valuable information about not only the ambiguous cytology results of ASCUS and LSIL but also the effect of the specific HPV type and other various factors on the progression to HSIL. Finally, the results of our study will be helpful and applicable to determine the primary cervical cancer prevention strategies.
Department of Preventive Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Won-Chul
WC
Lee
Sae-Young
SY
Lee
Yu Jin
YJ
Koo
Tae-Jin
TJ
Kim
Soo Young
SY
Hur
Sung Ran
SR
Hong
Sung Soon
SS
Kim
Mee-Kyung
MK
Kee
Jee Eun
JE
Rhee
Joo Shil
JS
Lee
Ho Sun
HS
Choi
Chi Heum
CH
Cho
Ki Tae
KT
Kim
Jong Sup
JS
Park
Cervical intraepithelial neoplasms; Cohort studies; Human papillomavirus; Uterine cervical neoplasms