An implantable neural stimulator for intraspinal microstimulation.
This paper reports on a wireless stimulator device for use in animal experiments as part of an ongoing investigation into intraspinal stimulation (ISMS) for restoration of walking in humans with spinal cord injury. The principle behind using ISMS is the activation of residual motor-control neural networks within the spinal cord ventral horn below the level of lesion following a spinal cord injury. The attractiveness to this technique is that a small number of electrodes can be used to induce bilateral walking patterns in the lower limbs. In combination with advanced feedback algorithms, ISMS has the potential to restore walking for distances that exceed that produced by other types of functional electrical stimulation. Recent acute animal experiments have demonstrated the feasibility of using ISMS to produce the coordinated walking patterns. Here we described a wireless implantable stimulation system to be used in chronic animal experiments and for providing the basis for a system suitable for use in humans. Electrical operation of the wireless system is described, including a demonstration of reverse telemetry for monitoring the stimulating electrode voltages.
Illinois institute of Technology, Chicago, IL 60616, USA. troyk@iit.edu
Philip R
PR
Troyk
Vivian K
VK
Mushahwar
Richard B
RB
Stein
Sungjae
S
Suh
Dirk
D
Everaert
Brad
B
Holinski
Zhe
Z
Hu
Glenn
G
DeMichele
Douglas
D
Kerns
Kevin
K
Kayvani
D000465:Algorithms; D000818:Animals; D002415:Cats; D004599:Electric Stimulation Therapy / Q000295:instrumentation / Q000379:methods; D004567:Electrodes, Implanted; D006801:Humans; D035002:Lower Extremity / Q000503:physiopathology; D009046:Motor Neurons / Q000473:pathology; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology; D013116:Spinal Cord; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D059015:Wireless Technology / Q000295:instrumentation*