Charlson comorbidity index in ischemic stroke and intracerebral hemorrhage as predictor of mortality and functional outcome after 6 months.
BACKGROUND
The Charlson Comorbidity Index (CCI) is commonly used in outcome and mortality studies. Our aim was to investigate the association between CCI score and the functional outcome and mortality 6 months after ischemic stroke (IS) or intracerebral hemorrhage.


METHODS
This was a prospective observational cohort of patients with spontaneous intracerebral hemorrhage and IS admitted to the stroke unit during 18 months. The modified Rankin scale (mRS) score was obtained for subjects 6 months after event. The CCI score was dichotomized (low comorbidity 0 or 1 versus high ≥ 2) for analysis. The mRS score was also dichotomized (good outcome, mRS score 0 or 1 versus poor outcome, mRS score ≥ 2).


RESULTS
In all, 175 patients were enrolled in the study. Logistic regression showed that those with a high CCI score (≥ 2) had 37.3% increased odds of having a poor outcome (≥ 2) at 6 months and 68.4% greater odds of death at 6 months.


CONCLUSIONS
Comorbid medical conditions independently influence outcome after IS or intracerebral hemorrhage.
Department of Neurology, San Pedro de Alcántara Hospital, Cáceres, Spain. Electronic address: pjimenez1010j@yahoo.es.
Pedro Enrique
PE
Jiménez Caballero
Fidel
F
López Espuela
Juan Carlos
JC
Portilla Cuenca
José María
JM
Ramírez Moreno
Juan Diego
JD
Pedrera Zamorano
Ignacio
I
Casado Naranjo
D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000453:epidemiology* / Q000401:mortality; D002543:Cerebral Hemorrhage / Q000453:epidemiology* / Q000401:mortality; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D020521:Stroke / Q000453:epidemiology* / Q000401:mortality
Charlson index; Ischemic stroke; comorbidity; intracerebral hemorrhage; mortality; outcome assessment