Inflammation makes T cells sensitive.
Inflammatory cytokines shape CD8(+) T cell responses. In this issue of Immunity, Richer et al. (2013) and Raue et al. (2013) demonstrate that inflammatory cytokines dynamically fine-tune antigen sensitivity of CD8(+) T cells to potently detect and better eliminate infected cells.
Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. lizbwilson@ucla.edu
Elizabeth B
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Wilson
David G
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Brooks