Assessing the effects of estrogen on the dynamics of breast cancer.
Worldwide, breast cancer has become the second most common cancer in women. The disease has currently been named the most deadly cancer in women but little is known on what causes the disease. We present the effects of estrogen as a risk factor on the dynamics of breast cancer. We develop a deterministic mathematical model showing general dynamics of breast cancer with immune response. This is a four-population model that includes tumor cells, host cells, immune cells, and estrogen. The effects of estrogen are then incorporated in the model. The results show that the presence of extra estrogen increases the risk of developing breast cancer.
Department of Applied Mathematics, National University of Science and Technology, Ascot, Bulawayo, Zimbabwe. chipmuf@gmail.com
Chipo
C
Mufudza
Walter
W
Sorofa
Edward T
ET
Chiyaka
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000209:etiology / Q000276:immunology* / Q000378:metabolism* / Q000628:therapy; D045744:Cell Line, Tumor; D004967:Estrogens / Q000009:adverse effects / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015994:Incidence; D015233:Models, Statistical; D012307:Risk Factors
D018931:Antineoplastic Agents, Hormonal; D004967:Estrogens