Spectrum of bone marrow failures of myeloid series: new report of neutropenic patients from a referral pediatric center in Iran.
Neutropenia is a reduction of the absolute neutrophil count (ANC), which could be seen in different conditions, while its association with a number of primary immunodeficiency diseases has been reported. This study was performed in all neutropenic patients who were admitted in a referral pediatric hospital during a 6-year period (2006-2011). One hundred and forty patients with ANC of below 1500/mm(3) were investigated in this study. The most common causes of neutropenia were severe congenital neutropenia (41%), aplastic anemia (19%), cyclic neutropenia (11%), hyperimmunoglobulin M syndrome (9%), and fanconi anemia (7%). The patients experienced their first manifestation at a median age of 1 year, while the median diagnostic age was 21 months. Parental consanguinity was present in about half of the cases. The most common clinical manifestations of the patients were sinusitis (62 cases), periodontitis (51 cases), acute diarrhea (39 cases), pneumonia (38 cases), abscess (36 cases), skin rashes (35 cases), and otitis media (31 cases). Twenty two patients (16%) died during the study period. Considering the differential diagnosis of neutropenia, making the diagnosis and appropriate treatments are the keys in management of patients with neutropenia to avoid further complications.
Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Taghi
MT
Majnoon
Setareh
S
Mamishi
Kasra
K
Moazzami
Leila
L
Shahbaznejad
Mina
M
Izadyar
Farah
F
Sabouni
Leila
L
Koochakzadeh
Asghar
A
Ramyar
Asghar
A
Aghamohammadi
Nima
N
Rezaei
D000293:Adolescent; D001855:Bone Marrow Diseases / Q000097:blood* / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009503:Neutropenia / Q000097:blood / Q000151:congenital* / Q000175:diagnosis / Q000235:genetics