[Study on comprehensive monitoring of mouse and effect of hemorrhagic fever with renal syndrome vaccine in high prevalence areas of natural focus infectious disease of Zhejiang province in 1994--2010].
OBJECTIVE
To study the comprehensive monitoring mechanism of mouse and the effect of hemorrhagic fever with renal syndrome (HFRS) vaccine in the high prevalence areas of natural focus infectious disease of Zhejiang province in 1994 - 2010.


METHODS
The night trapping method was used to monitor the population proportion, density and the rate of hantavirus (HV) carriers in mice in Xikou township Longyou county in August and September from 1994 to 2010. The healthy residents in Xikou township aged 16 to 60 years were recruited. The subjects were randomly selected as vaccination group and control group according to age, sex, occupational distribution (10 178 in intervention group and 16 159 in control group). Intervention group was given purified and inactivated vaccine from suckling mouse brain, while the control group received no intervention. The prevention effect was evaluated by protective rate of vaccine.


RESULTS
The mouse population was stable in the sixteen years and the apodemus agrarius was the main type (76.5% (564/737)). The average density of mouse was 4.73% (1170/24 727). The average rate of virus carrier of mouse was 3.87% (41/1033). In 1994 - 1995, the density of mouse was 22.82% (186/815) and the rate of virus carrier was 7.0% (10/143). In 2009 - 2010, the density of mouse decreased to 2.75% (119/4330) and the rate of virus carrier was 5.5% (13/237). The average antibody positive rate of mouse from 2005 to 2010 was 4.8% (35/728) and the rate was 4.4% (6/138), 0.0% (0/113), 11.8% (16/136), 1.0% (1/104), 3.7% (4/109) and 6.3% (8/128) in each year (P < 0.01). The protective rate of HFRS vaccine was 96.2% (1 case in intervention group and 41 cases in control group).


CONCLUSIONS
The density of mouse decreased significantly in Zhejiang province. The rate of virus carrier of mouse is stable. The vaccine is effective.
Communicable Disease Control and Prevention Department, Zhejiang Center for Disease Control and Prevention, Zhejiang Province, Hangzhou 310051, China.
Zhen-yu
ZY
Gong
Juan
J
Hou
Qi-yong
QY
Liu
Jin-bao
JB
Lei
Zhong-bing
ZB
Chen
Chun-fu
CF
Fang
Han-ping
HP
Zhu
Feng
F
Ling
Ji-min
JM
Sun
D000293:Adolescent; D000328:Adult; D000818:Animals; D002681:China / Q000453:epidemiology; D004197:Disease Reservoirs; D004784:Environmental Monitoring; D005260:Female; D006476:Orthohantavirus; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009115:Muridae; D014611:Vaccination; D014765:Viral Vaccines / Q000627:therapeutic use*; D055815:Young Adult
D014765:Viral Vaccines