[State of the dopamine system activity, as one of factors for the development of arterial hypertension and obesity].
The discovery of 5 subtypes of dopamine receptors revealed their important role in development of arterial hypertension and obesity. Reduce of their functional activity or number with age conduces to the increase of tone of the sympathetic nervous system, dyspoiesis of leptin, hyperphagia, development of obesity and arterial hypertension. Prescription of dopamine agonists conduces to reduction of in, normalization of leptin, diminishing of appetite and body mass, decrease of blood pressure. Combination of arterial hypertension and obesity is recommended to determine dopamine excretion and to appoint dopamine agonists at level of < 600 nmol/24 hours.
V H
VH
Lyzogub
O V
OV
Dolynna
T V
TV
Bogdan
V O
VO
Sobol'
D000328:Adult; D000368:Aged; D001066:Appetite / Q000187:drug effects; D062186:Arterial Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology / Q000627:therapeutic use*; D004298:Dopamine / Q000097:blood / Q000652:urine; D018491:Dopamine Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D009765:Obesity / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000378:metabolism
D018491:Dopamine Agonists; D020738:Leptin; D011954:Receptors, Dopamine; D001971:Bromocriptine; D004298:Dopamine; D009638:Norepinephrine