Synthesis of quinolones by nickel-catalyzed cycloaddition via elimination of nitrile.
Substituted quinolones were efficiently synthesized via the nickel-catalyzed cycloaddition of o-cyanophenylbenzamide derivatives with alkynes. The reaction involves elimination of a nitrile group by cleavage of the two independent aryl-cyano and aryl-carbonyl C-C bonds of the amides.
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Kenichiro
K
Nakai
Takuya
T
Kurahashi
Seijiro
S
Matsubara
D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry; D002384:Catalysis; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D000577:Amides; D009570:Nitriles; D015363:Quinolones; D009532:Nickel