Acquired bartter-like syndrome associated with colistin use in a preterm infant.
Acquired Bartter-like syndrome (BLS), characterized by hypokalemic metabolic alkalosis, hypomagnesemia, hypocalcemia, and normal kidney function, can be induced by diuretics or antibiotics. It is a very rare condition and only anecdotal cases mostly in adults were reported. Although tubulopathy associated with colistin was reported in adults, to the best of our knowledge, colistin-associated BLS neither in adults nor in children has been reported in the literature. We here report a-28-week, 740 g female preterm infant who developed BLS just after colistin treatment for Acinetobacter baumannii infection and recovered few days after the drug cessation, and discuss the possible association of colistin and tubulopathy. More research on colistin pharmacokinetics and pharmacodynamics in critically ill patients and preterm infants is needed to guide adequate colistin dosing at the least toxicity.
Division of Neonatology, Ankara University School of Medicine Children's Hospital, Ankara, Turkey. drufukcakir@hotmail.com
Ufuk
U
Cakir
Serdar
S
Alan
Cengiz
C
Zeybek
Omer
O
Erdeve
Begum
B
Atasay
Fatma
F
Yalcinkaya
Saadet
S
Arsan
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001477:Bartter Syndrome / Q000139:chemically induced / Q000175:diagnosis; D003091:Colistin / Q000009:adverse effects*; D020345:Enterocolitis, Necrotizing / Q000188:drug therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000139:chemically induced* / Q000188:drug therapy; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis; D011247:Pregnancy
D000900:Anti-Bacterial Agents; D003091:Colistin