[Antioxidant and cerebroprotective action of N-,S-chinazolone derivative under rat brain ischemia].
Under modelling of brain ischemia in rats the antioxidant and cerebroprotective action of new N-,S-chinazolone derivative--compound NC-224 has been established. The compensation of pathobiochemical abnormalities in the system "LPO-antioxidant protection" is observed, indicators of carbohydrate metabolism and energy-supply, and morpho-functional status of brain cells are improved under administration of the compound NC-224. Administration of the compound NC-224 to rats promoted a decrease of the lethality index and signs of neurological deficiency.
Iu I
IuI
Hubs'kyĭ
I F
IF
Bielenichev
S I
SI
Kovalenko
H H
HH
Goriushko
N V
NV
Bukhtiiarova
N V
NV
Litvinova
V S
VS
Nikitin
S V
SV
Pavlov
L P
LP
Babenko
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D002374:Catalase / Q000378:metabolism; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009457:Neuroglia / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010889:Piracetam / Q000494:pharmacology / Q000627:therapeutic use; D011799:Quinazolines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D015996:Survival Rate
D000975:Antioxidants; D018696:Neuroprotective Agents; D011799:Quinazolines; D002374:Catalase; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D000254:Sodium-Potassium-Exchanging ATPase; D010889:Piracetam