Invasive sino-orbital mycosis in an aplastic anemia patient caused by Neosartorya laciniosa.
We report the first case of Neosartorya laciniosa invasive sinusitis involving the orbit in an immunocompromised male with aplastic anemia. Treatment included surgical debridement with enucleation of the eye and combination voriconazole and micafungin therapy followed by voriconazole alone. The fungus was identified using sequencing of partial benA and calmodulin genes.
Department of Laboratory Medicine and Pathology, Division of Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada.
Kathy
K
Malejczyk
Lynne
L
Sigler
Connie Fe C
CF
Gibas
Stephanie W
SW
Smith
D000368:Aged; D000741:Anemia, Aplastic / Q000150:complications*; D000935:Antifungal Agents / Q000008:administration & dosage; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D003646:Debridement; D054714:Echinocandins / Q000008:administration & dosage; D015353:Eye Enucleation; D005656:Fungal Proteins / Q000235:genetics; D006801:Humans; D055666:Lipopeptides / Q000008:administration & dosage; D008297:Male; D000077551:Micafungin; D008969:Molecular Sequence Data; D009181:Mycoses / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology* / Q000628:therapy; D055326:Neosartorya / Q000235:genetics / Q000302:isolation & purification*; D009916:Orbital Diseases / Q000150:complications / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D010802:Phylogeny; D011743:Pyrimidines / Q000008:administration & dosage; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D012852:Sinusitis / Q000150:complications / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D014230:Triazoles / Q000008:administration & dosage; D065819:Voriconazole
D000935:Antifungal Agents; D004271:DNA, Fungal; D054714:Echinocandins; D005656:Fungal Proteins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole; D000077551:Micafungin