An analysis of the expression locus of long-term potentiation in hippocampal CA1 neurons.
Long-term potentiation (LTP) has long been understood as an increase in the potency of a synaptic connection between two neurons. In this study, we combine a previously developed two-stage cascade model with electrophysiological recordings of rat hippocampal CA1 pyramidal cells both before and after LTP to analyze linear and nonlinear contributions of pre and post-synaptic partners to the strengthening of their synaptic connectivity. The result suggests that the major nonlinear expression locus of LTP exists in the post-synaptic side. Additionally, the report reveals that LTP should be understood not only in the traditional view as a change in the magnitude of communication between two cells, but also as a change in their temporal coding properties of information exchange.
Department of Neuroscience, University of Southern California, Los Angeles, CA 90089, USA. shaneroa@usc.edu
Shane M
SM
Roach
Ude
U
Lu
Dong
D
Song
Theodore W
TW
Berger
D000818:Animals; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D017774:Long-Term Potentiation; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley