Use of biomarkers in the management of children with lupus.
Childhood systemic lupus erythematosus (SLE) is known to have a worse prognosis than adult-onset disease, and monitoring and treatment of the disease are still a challenge. Thus, there is an urgent need for highly reliable, non-invasive biomarkers for early detection of relapses, to avoid long-term complications and to optimize the management of children with LN. Recent studies of pediatric patients have yielded novel specific biomarkers for SLE diagnosis which can be used for monitoring disease activity and response to treatment. The most promising biomarkers in juvenile-onset SLE include cell-bound complement activation products, some genomic profiles, and urinary proteins such as neutrophil gelatinase-associated lipocalin, monocyte chemoattractant protein-1, and alpha-1-acid glycoprotein. None of these might be suitable for use as a single SLE-biomarker. More likely a combination of novel biomarkers with traditionally used data, including autoantibodies and complement, might help to enhance sensitivity and specificity for early diagnosis, disease monitoring, and prediction of relapses.cp.
Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria. elisabeth.binder@i-med.ac.at
Elisabeth
E
Binder
Monika
M
Edelbauer
D000209:Acute-Phase Proteins / Q000652:urine; D001323:Autoantibodies / Q000097:blood; D001402:B-Lymphocytes; D015415:Biomarkers / Q000097:blood / Q000652:urine; D018932:Chemokine CCL2 / Q000652:urine; D002648:Child; D003165:Complement System Proteins / Q000032:analysis; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000652:urine; D009961:Orosomucoid / Q000652:urine; D011518:Proto-Oncogene Proteins / Q000652:urine; D013601:T-Lymphocytes
D000209:Acute-Phase Proteins; D001323:Autoantibodies; D015415:Biomarkers; D018932:Chemokine CCL2; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D009961:Orosomucoid; D011518:Proto-Oncogene Proteins; D003165:Complement System Proteins