[Limbic encephalitis with positive anti-N-methyl-D-aspartate antibodies. Report of one case].
Limbic encephalitis is a subacute syndrome characterized by memory impairment, confusion, seizures, hypothalamic dysfunction and psychiatric symptoms. It has been associated to tumors located outside of the central nervous system. In 2007, anti-N-methyl-D-aspartate receptors (NMDAr) antibodies were found in serum and CSF of patients with this particular type of encephalitis. We report a 25-year-old female who, following upper respiratory tract symptoms, developed serious behavioral and consciousness impairment that progressed to coma. Cerebrospinal fluid (CSF) analysis showed a lymphocyte pleocytosis, the electroencephalogram was altered with a slow encephalopathic rhythm and a brain magnetic resonance imaging was normal. Infectious etiologies were ruled out. CSF and serum anti NMDA receptors antibodies were positive.
Departamento de Ciencias Neurológicas, Hospital del Salvador, Facultad de Medicina, Universidad de Chile, Chile.
David B
DB
Martínez
Rodrigo T
RT
Guerrero
Marcela B
MB
Grandjean
Luis R
LR
Cartier
D000328:Adult; D000906:Antibodies / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D020363:Limbic Encephalitis / Q000175:diagnosis* / Q000503:physiopathology; D016202:N-Methylaspartate / Q000276:immunology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*
D000906:Antibodies; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate