Diabetes mellitus and elevated copeptin levels in middle age predict low cognitive speed after long-term follow-up.
OBJECTIVE
We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort.


METHODS
Participants (n = 933) were investigated using baseline data, including copeptin levels, and data collected 16 years later using the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT).


RESULTS
Logistic regression showed that diabetes (OR, 1.86; p < 0.05) and higher copeptin levels (OR, 1.19; p < 0.05) were independently associated with an increased risk of low AQT performance.


CONCLUSIONS
Prevalence of diabetes mellitus and elevated copeptin levels in middle age predict lower cognitive speed after long-term follow-up.
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden. eva.tufvesson@gmail.com
Eva
E
Tufvesson
Olle
O
Melander
Lennart
L
Minthon
Margaretha
M
Persson
Peter M
PM
Nilsson
Joachim
J
Struck
Katarina
K
Nägga
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000378:metabolism* / Q000523:psychology*; D015331:Cohort Studies; D055316:Cystatin C / Q000097:blood; D003920:Diabetes Mellitus / Q000378:metabolism*; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006020:Glycopeptides / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D013548:Sweden / Q000453:epidemiology
D015415:Biomarkers; D055316:Cystatin C; D006020:Glycopeptides; D008055:Lipids; C048197:copeptins