Salmon calcitonin reduces oxaliplatin-induced cold and mechanical allodynia in rats.
Oxaliplatin is commonly used anti-cancer drugs, but it frequently causes peripheral neuropathic pain. Recently, we reported that elcatonin, a synthetic analog of eel calcitonin, attenuated the oxaliplatin- and paclitaxel-induced cold and mechanical allodynia in rats. In the present study, we determined whether salmon calcitonin also had anti-allodynic effects on oxaliplatin-induced neuropathy in rats. The rats were treated with a single dose of oxaliplatin (6 mg/kg, intraperitoneally (i.p.)). Oxaliplatin resulted in cold and mechanical allodynia. We assessed the anti-allodynic effects of subcutaneously administered salmon calcitonin (20 U/kg/d) by cold stimulation (8°C) directly to the hind paw of the rats and by using the von Frey test. Salmon calcitonin almost completely reversed the effects of both cold and mechanical allodynia. These results suggest that salmon calcitonin is also useful for treatment of oxaliplatin-induced neuropathy clinically.
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University, 5–9–1 Shirokane, Minato-ku, Tokyo 108–8641, Japan.
Manahito
M
Aoki
Asami
A
Mori
Tsutomu
T
Nakahara
Kenji
K
Sakamoto
Kunio
K
Ishii
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D002116:Calcitonin / Q000627:therapeutic use*; D003080:Cold Temperature; D006930:Hyperalgesia / Q000188:drug therapy*; D008297:Male; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000700:Analgesics; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; C028815:salmon calcitonin; D002116:Calcitonin