Efficacy of a single high oxfendazole dose against gastrointestinal nematodes in naturally infected pigs.
The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ) administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris suis. Thirty-six local ecotype piglets were divided into three independent experiments, named I, II and III (n=12 each), respectively. Each experiment involved two different groups (n=6): Untreated Control and OFZ treated. Animals were naturally parasitized with A. suum (Experiments I, II and III), Oesophagostomum spp. (Experiments I and II), T. suis (Experiments II and III) and Metastrongylus spp. (Experiment I). Pigs in the treated group received OFZ (Synanthic(®), Merial Ltd., 9.06% suspension) orally at 30 mg/kg dose. At five (5) days post-treatment, animals were sacrificed and the clinical efficacy of the OFZ treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. OFZ treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, OFZ orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp.
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Campus Universitario, 7000 Tandil, Argentina. lalvarez@vet.unicen.edu.ar
Luis
L
Alvarez
Carlos
C
Saumell
Luis
L
Fusé
Laura
L
Moreno
Laura
L
Ceballos
Gilbert
G
Domingue
Meritxell
M
Donadeu
Baptiste
B
Dungu
Carlos
C
Lanusse
D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D041981:Gastrointestinal Tract / Q000469:parasitology; D006374:Helminthiasis, Animal / Q000188:drug therapy* / Q000469:parasitology; D009348:Nematoda / Q000187:drug effects*; D010270:Parasite Egg Count / Q000662:veterinary; D013045:Species Specificity; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000469:parasitology
D000969:Antinematodal Agents; D001562:Benzimidazoles; C011030:oxfendazole