Cilia, tubby mice, and obesity.
Primary cilia have been previously linked to the central regulation of satiety. The tubby mouse is characterized by maturity-onset obesity and blindness. A recent paper demonstrates molecular defects in trafficking of ciliary GPCRs in the central neurons of tubby mice, underscoring the role of ciliary signaling in the pathogenesis of this monogenic obesity syndrome. Please see related Research article by Li et al., http://www.ciliajournal.com/content/1/1/21.
Department of Research Oncology, Genentech Inc, South San Francisco, CA, 94080, USA ; Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Saikat
S
Mukhopadhyay
Department of Research Oncology, Genentech Inc, South San Francisco, CA, 94080, USA.
Peter K
PK
Jackson