Acute promyelocytic leukemia-associated thrombosis.
Patients with acute promyelocytic leukemia (APL) are prone to both bleeding and thrombosis. The bleeding complications are well known. In contrast, APL-associated thrombosis is relatively underappreciated. We aimed to explore the issue of APL-associated thrombosis events. In the past 20 years, 127 cases with APL were found in our hospital database. We collected their coagulation laboratory profiles, including leukemia burdens, white blood cell and platelet counts, prothrombin time, activated partial thromboplastin time, fibrinogen levels, and disseminated intravascular coagulation scores. Data were compared between patients with or without thrombosis. Clinical outcomes and potential risk factors were obtained for analysis. Ten cases with APL-associated thrombosis were found. The incidence of thrombosis was 7.9% in our cohort. Five patients had cerebral infarction, 5 had catheter-related thrombosis and 1 had acute myocardial infarction. No laboratory data were associated with clinical thrombosis. Three patients died during the induction phase but thrombosis was not the direct cause of death for any of them. We conclude that patients with APL are susceptible to thrombosis in addition to bleeding. Laboratory coagulation parameters did not predict thrombosis in our series. Ischemic stroke and catheter-related thrombosis were the most common events in our Taiwanese cohort. Such a thrombosis pattern is unique and worth further investigation.
Division of Hematology-Oncology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.
Hung
H
Chang
Ming-Chung
MC
Kuo
Lee-Yung
LY
Shih
Jin-Hou
JH
Wu
Tung-Liang
TL
Lin
Po
P
Dunn
Tzung-Chih
TC
Tang
Yu-Shin
YS
Hung
Po-Nan
PN
Wang
D000328:Adult; D000368:Aged; D001780:Blood Coagulation Tests; D016208:Databases, Factual; D004211:Disseminated Intravascular Coagulation / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D015473:Leukemia, Promyelocytic, Acute / Q000453:epidemiology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D013927:Thrombosis / Q000453:epidemiology* / Q000628:therapy*; D055815:Young Adult