Relationship between the solution thermodynamic properties of naproxen in organic solvents and its release profiles from PLGA microspheres.
Naproxen (NPX)-loaded poly-(D,L-lactic-co-glycolic acid) (PLGA) microparticles were prepared by the emulsion-solvent evaporation method. The different organic solvents used significantly affects the properties of the microparticles obtained. These microparticles exhibited a controlled release profile that extends up to 15 days depending on the organic solvent used. The formulations did not exhibit zero- or first-order release kinetics and no agreement with Higuchi or Korsmeyer-Peppas models was obtained. In all cases, the dissolution profiles were fitted to the model proposed by Gallagher and Corrigan for PLGA systems. It was found that this model fully describes the dissolution processes. An interesting relationship between the NPX solubility in the organic solvents studied and some parameters obtained for the dissolution model of the microparticles prepared with the same solvents is thus obtained. Accordingly, it can be proposed that the drug solubility in organic solvents is relevant to estimate the physical characteristics of microparticles other than its dissolution profiles.
Sección de Farmacotecnia, Departamento de Farmacia, Universidad Nacional de Colombia, Sede Bogotá, Colombia. dmaragonn@unal.edu.co
Diana Marcela
DM
Aragón
Jaiver Eduardo
JE
Rosas
Fleming
F
Martínez
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry; D009288:Naproxen / Q000737:chemistry*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D013816:Thermodynamics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012997:Solvents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D009288:Naproxen