Sinus node dysfunction: an adverse effect of lacosamide.
Lacosamide, a recently introduced antiepileptic drug, acts by enhancing the slow inactivation of voltage-dependent sodium channels. Cardiac conduction disturbances, namely atrial fibrillation and atrioventricular block, have been reported in patients with epilepsy. We report a patient with drug-resistant focal epilepsy who developed asymptomatic sinus node dysfunction following lacosamide use, which resolved on stopping lacosamide. This is the first report of sinus node dysfunction associated with lacosamide therapy.
Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery, London, United Kingdom. dr.chinnasami.suganthi@gmail.com
Suganthi
S
Chinnasami
Chaturbhuj
C
Rathore
John S
JS
Duncan
D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004562:Electrocardiography; D004828:Epilepsies, Partial / Q000188:drug therapy; D005260:Female; D006801:Humans; D000078334:Lacosamide; D008875:Middle Aged; D012804:Sick Sinus Syndrome / Q000139:chemically induced* / Q000175:diagnosis
D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide