RKIP: much more than Raf kinase inhibitory protein.
From its discovery as a phosphatidylethanolamine-binding protein in bovine brain to its designation as a physiological inhibitor of Raf kinase protein, RKIP has emerged as a critical molecule for maintaining subdued, well-orchestrated cellular responses to stimuli. The disruption of RKIP in a wide range of pathologies, including cancer, Alzheimer's disease, and pancreatitis, makes it an exciting target for individualized therapy and disease-specific interventions. This review attempts to highlight recent advances in the RKIP field underscoring its potential role as a master modulator of many pivotal intracellular signaling cascades that control cellular growth, motility, apoptosis, genomic integrity, and therapeutic resistance. Specific biological and functional niches are highlighted to focus future research towards an enhanced understanding of the multiple roles of RKIP in health and disease.
Faculty of Medicine, Department of Pathology, Kuwait University Health Sciences Centre, Safat, Kuwait. fahd@al-mulla.org
Fahd
F
Al-Mulla
Milad S
MS
Bitar
Zainab
Z
Taqi
Kam C
KC
Yeung
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D001483:Base Sequence; D002417:Cattle; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D004351:Drug Resistance / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D020935:MAP Kinase Signaling System / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D049488:Phosphatidylethanolamine Binding Protein / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D048490:raf Kinases / Q000037:antagonists & inhibitors*
D049488:Phosphatidylethanolamine Binding Protein; D048490:raf Kinases