Solid lipid particles in lipid films to control the diffusive release of 2-heptanone.
BACKGROUND
Controlled-release formulations of bioactive agents are of increasing interest for effective pest control. Volatile 2-heptanone is a bioactive agent that has shown potential as a pesticide. The aim of this study was to investigate the kinetics of release of 2-heptanone incorporated into lipid films or composite solid lipid particle (SLP) films.


RESULTS
Effective 2-heptanone diffusivity was estimated to be between 0.1 and 2.5 mm(2)  day(-1) during the first week and between 0.05 and 0.1 mm(2)  day(-1) during the next 5 weeks. The films that showed better retention of 2-heptanone were the paraffin lipid films. Inclusion of SLPs into paraffin films increased the release rate of 2-heptanone, mainly owing to a decrease in the film firmness as the composite SLP film became less crystalline and more brittle. In contrast, SLPs decreased the kinetics of 2-heptanone release in Acetem films owing to an increase in the film firmness.


CONCLUSIONS
The results indicated that the use of SLPs as a method for controlled release can improve the delivery of the natural pesticide 2-heptanone if the SLPs have good compatibility with the matrix, leading to an increase in firmness of the films without increasing their porosity. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
Western Regional Research Center, ARS, US Department of Agriculture, CA, USA. cristina.bilbao@ars.usda.gov
Cristina
C
Bilbao-Sáinz
Bor-Sen
BS
Chiou
Greg M
GM
Glenn
Kay S
KS
Gregorsky
Tina G
TG
Williams
Delilah F
DF
Wood
Artur P
AP
Klamczynski
William J
WJ
Orts
D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D007700:Kinetics; D008055:Lipids / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007659:Ketones; D008055:Lipids; C011917:2-heptanone
2-heptanone; controlled release; film; solid lipid particles