Analysis of adhesions resulted from mesh fixation with fibrin sealant and suture: experimental intraperitoneal model.
OBJECTIVE
To compare surgical fixation of polypropylene mesh (PP) and coated polypropylene mesh (PCD) using polypropylene suture and fibrin glue, as for the formation of intraperitoneal adhesions.


METHODS
A sample of 46 female Wistar rats were randomized into six groups: two control groups, with five rats each, were subjected to one medial incision (MI) and the other to a U-shaped incision (UI), none of these groups received the mesh. Two groups of PP mesh, with ten rats, fixed with suture (PPF), the other with six rats, fixed with biological glue (PPC). And two groups of PCD mesh, at first, with ten animals, the mesh was fixed with sutures (PCDFs) and the second with ten animals with biological glue (PCDC).


RESULTS
After 21 days, the control groups showed no significant adhesions. The PPC group showed a lower degree of adhesion than the PPF group (p = 0.01). There was no difference between the groups with PCD.


CONCLUSIONS
Comparison of fixation was statistically different only with PP mesh, with lesser degrees of adherence when using the glue. Adhesions were predominantly located at the extremities of the meshes studied.
Experimental Laboratory, Institute for Basic Health Sciences, Lutheran University of Brazil (ULBRA), Brazil. montesjuliano@gmail.com
Juliano Hermes Maeso
JH
Montes
André Vicente
AV
Bigolin
Renata
R
Baú
Roberto
R
Nicola
João Vicente Machado
JV
Grossi
Cláudia Juliana
CJ
Loureiro
Leandro Totti
LT
Cavazzola
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000009:adverse effects*; D010537:Peritoneum / Q000601:surgery*; D011126:Polypropylenes; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000209:etiology*; D014014:Tissue Adhesives / Q000009:adverse effects*
D015718:Fibrin Tissue Adhesive; D011126:Polypropylenes; D014014:Tissue Adhesives