pH dependent multifunctional and multiply-configurable logic gate systems based on small molecule G-quadruplex DNA recognition.
A variety of logic operations such as XNOR, NOR, AND, NAND, NOT have been designed with pH as an external modulator by choosing thiazole orange (TO) and a c-kit2 promoter quadruplex as two inputs and fluorescence signals of pyridyl bis-indole amide (PBIA) and TO as two outputs.
Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032, India.
Sudipta
S
Bhowmik
Rabindra Nath
RN
Das
Bibudha
B
Parasar
Jyotirmayee
J
Dash
D052160:Benzothiazoles / Q000737:chemistry*; D054856:G-Quadruplexes; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
D052160:Benzothiazoles; D007211:Indoles; D011725:Pyridines; D011804:Quinolines; C051000:thiazole orange