Changes in translational control after pro-apoptotic stress.
In stressed cells, a general decrease in the rate of protein synthesis occurs due to modifications in the activity of translation initiation factors. Compelling data now indicate that these changes also permit a selective post-transcriptional expression of proteins necessary for either cell survival or completion of apoptosis when cells are exposed to severe or prolonged stress. In this review, we summarize the modifications that inhibit the activity of the main canonical translation initiation factors, and the data explaining how certain mRNAs encoding proteins involved in either cell survival or apoptosis can be selectively translated.
INSERM UMR-1037 Université de Toulouse, Centre de Recherche en Cancérologie de Toulouse (CRCT) and Laboratoire d'Excellence Toulouse Cancer, TOUCAN, Toulouse 31432, France. stephane.pyronnet@inserm.fr.
Charline
C
Lasfargues
Yvan
Y
Martineau
Corinne
C
Bousquet
Stéphane
S
Pyronnet
D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D006801:Humans; D010448:Peptide Initiation Factors / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013312:Stress, Physiological
D010448:Peptide Initiation Factors; D012333:RNA, Messenger