Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation.
OBJECTIVE
There is increasing evidence linking inflammation and oxidative stress to atrial fibrillation (AF). In this study, we tested the hypothesis that C-reactive protein (CRP) and oxidative stress markers can predict the recurrence of persistent AF after successful pharmacological cardioversion. A possible relationship with AF occurrence was also investigated.


METHODS
Using a case-control study design, CRP, catalase, superoxide dismutase (SOD), and malondialdehyde (MDA) levels of 42 patients (23 female, 19 male; mean age 58.4±13.6 years) with documented persistent AF episodes were compared with 21 controls (9 female; 12 male; mean age 58.1±6.9 years).


RESULTS
Overall AF patients were followed for 6 months, and 17 showed recurrence. Then, they were divided into two groups (recurrence and no recurrence) and compared with each other. CRP, SOD, and MDA levels were significantly higher in AF patients compared with controls. However, only CRP levels were significantly higher in patients with AF recurrence compared to those without recurrence.


CONCLUSIONS
Increased markers of inflammation and oxidative stress are found in patients with persistent AF, suggesting that inflammation and oxidative stress may be associated with the presence of arrhythmia.
Department of Cardiology, Afşin State Hospital, Kahramanmaraş, Turkey. m.sedatkoroglu@gmail.com.
Sedat
S
Köroğlu
Cemal
C
Tuncer
Gürkan
G
Acar
Ahmet
A
Akçay
Gülizar
G
Sökmen
Sıla
S
Yalçıntaş
Alper
A
Nacar
Burak
B
Altun
Abdullah
A
Sökmen
D001281:Atrial Fibrillation / Q000453:epidemiology; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D004554:Electric Countershock; D006801:Humans
D015415:Biomarkers; D002097:C-Reactive Protein