Rituximab seems a promising therapeutic option in granulomatosis with polyangiitis with intestinal perforation: a case report and literature review.
Granulomatosis with polyangiitis (Wegener's) (GPA) is a chronic disease of unknown aetiology that leads to necrotising vasculitis in small and medium-sized vessels characterised by respiratory system and kidney involvement. Intestinal involvement is rare and perforation is even rarer in GPA. In this study, we are presenting a literature review of related cases, and a 29-year-old man referred from the emergency department with a multiple distal ileal perforation that was diagnosed with GPA, and successfully treated with rituximab.
Department of Gastroenterology,  Gaziantep University, School of Medicine, Sahinbey Medical Center, Gaziantep,  Turkey.
Muhammet Sait
MS
Dag
Yavuz
Y
Pehlivan
Ediz
E
Tutar
Bunyamin
B
Kisacik
D000328:Adult; D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage / Q000627:therapeutic use*; D003113:Colonoscopy; D003937:Diagnosis, Differential; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007077:Ileal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use; D007275:Injections, Intravenous; D007416:Intestinal Perforation / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D000069283:Rituximab; D056647:Systemic Vasculitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab