Impact of preoperative radiotherapy on head and neck free flap reconstruction: a report on 429 cases.
BACKGROUND
The primary objective of this study was to evaluate the impact of preoperative radiotherapy on the outcomes of head and neck microvascular reconstruction. The secondary objective was to assess the specific effects of irradiation doses (IDs) ≥60 Gy on the outcomes of head and neck microvascular reconstruction.


METHODS
All patients who underwent head and neck free-flap reconstruction in our institution between 2000 and 2010 were included in this retrospective study. A total of 429 patients were enrolled including 136 patients previously irradiated on the head and neck. The impact of preoperative radiotherapy on free-flap success, local and general complications, postoperative mortality, time of decannulation, duration of enteral nutrition and length of stay was assessed in univariate and multivariate analyses.


RESULTS
In multivariate analysis, preoperative radiotherapy (irrespective of ID) was a significant risk factor for fistula formation (p = 0.003) and wound infection (p = 0.005). Previous neck irradiation at doses ≥60 Gy was associated with an increased risk of free-flap failure (p = 0.04), overall local complications (p = 0.05), haematoma (p = 0.04) and longer duration of enteral nutrition (p = 0.006) and hospital stay (p = 0.004).


CONCLUSIONS
Preoperative radiotherapy, particularly for ID ≥ 60 Gy, is one of the main determinants of the outcomes of head and neck microvascular reconstruction.
Department of Surgery, Institut Universitaire de la Face et du Cou, 31 avenue de Valombrose, 06103 Nice, France.
M J
MJ
Benatar
O
O
Dassonville
E
E
Chamorey
G
G
Poissonnet
M
M
Ettaiche
C S
CS
Pierre
K
K
Benezery
R
R
Hechema
F
F
Demard
J
J
Santini
A
A
Bozec
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D004750:Enteral Nutrition; D005260:Female; D058752:Free Tissue Flaps; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000601:surgery*; D020360:Neoadjuvant Therapy; D010610:Pharyngeal Neoplasms / Q000453:epidemiology / Q000532:radiotherapy / Q000601:surgery; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D019651:Plastic Surgery Procedures; D016896:Treatment Outcome; D055815:Young Adult