Labdane diterpenoids and lignans from Calocedrus macrolepis.
Three new labdane diterpenoids, calomacrins A-C (1-3), and a new diaryl butyrolactone-type lignan, calomacrol A (8), as well as four known labdane diterpenoids and six known lignans, were isolated from the twigs and leaves of Calocedrus macrolepis. Structures of the new compounds were elucidated on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. Compounds 3-14 were evaluated for cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Xing-De
XD
Wu
Shuang-Yan
SY
Wang
Lei
L
Wang
Juan
J
He
Gen-Tao
GT
Li
Lin-Fen
LF
Ding
Xun
X
Gong
Liao-Bin
LB
Dong
Liu-Dong
LD
Song
Yan
Y
Li
Qin-Shi
QS
Zhao
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D052117:Benzodioxoles / Q000737:chemistry / Q000302:isolation & purification*; D029779:Cupressaceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D061986:MCF-7 Cells
D000972:Antineoplastic Agents, Phytogenic; D052117:Benzodioxoles; D004224:Diterpenes; D015107:4-Butyrolactone