Cytochrome P17 inhibition with ketoconazole as treatment for advanced granulosa cell ovarian tumor.
Medical Oncology Department, Centro Integral Oncologico Clara Campal, Madrid, Spain. jgarciadonas@gmail.com
Jesus
J
Garcia-Donas
Alicia
A
Hurtado
Zaida
Z
García-Casado
Judith
J
Albareda
Jóse Antonio
JA
López-Guerrero
Isabel
I
Alemany
Enrique
E
Grande
Juan Carlos
JC
Camara
Susana
S
Hernando
D058888:14-alpha Demethylase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001483:Base Sequence; D005260:Female; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D006106:Granulosa Cell Tumor / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics; D013254:Steroid 17-alpha-Hydroxylase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D016896:Treatment Outcome
D058888:14-alpha Demethylase Inhibitors; C421604:FOXL2 protein, human; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors; D013254:Steroid 17-alpha-Hydroxylase; D007654:Ketoconazole; D006854:Hydrocortisone