Learning and survival memory undergoing a permanent bilateral carotid ligation in rats.
OBJECTIVE
To evaluate the effect of cerebral hypoxia-ischemia on memory and learning survival of rats submitted to permanent bilateral carotid ligation (PBCL).


METHODS
Twenty-four survivors of PBCL were evaluated after 30 days with regard to memory and learning using a water survival maze. Twenty-three healthy rats were used as control group. The results were expressed by their means and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee for animal investigation.


RESULTS
The mortality rate for the surgery was 44.4%. The latency time to find the survival platform was higher in rats that underwent PBCL (Normal: 10.24 ± 1.85s -


METHODS
25.30 ± 4.69s - Mann - Whitney p=0.0388). Additionally, the type of swimming and the spatial stability of the studied rats on the survival platform were compromised in these animals.


CONCLUSIONS
The permanent bilateral carotid ligation induces change in the learning and survival memory.
Department of Ophthalmology, FCM, Campina Grande, PB, Brazil.
Maria Cecília Santos Cavalcanti
MC
Melo
Diego
D
Gadelha
Guilherme Veras
GV
Mascena
Thárcia Kiara Beserra
TK
Oliveira
Carlos Teixeira
CT
Brandt
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply; D017536:Carotid Artery, Common / Q000503:physiopathology*; D020925:Hypoxia-Ischemia, Brain / Q000401:mortality / Q000503:physiopathology*; D007858:Learning / Q000502:physiology*; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar