Synthesis and carbonic anhydrase inhibitory properties of 1,3-dicarbonyl derivatives of methylaminobenzene-sulfonamide.
Abstract 1,3-Dicarbonyl derivatives of methylaminobenzene-sulfonamide were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and hCA II were evaluated. hCA I and hCA II from human erythrocytes were purified by a simple one-step procedure by using Sepharose 4B-L-tyrosine-sulfanilamide affinity column. Our results show that the synthesized compounds inhibited the activity of carbonic anhydrase (CA) I and CA II. Among them, 2b and 2e were found to be the most active (IC50=2.12 and 2.52 µM) for hCA I and hCA II, respectively.
Chemistry Department, Faculty of Arts and Sciences, Sakarya University , Sakarya, Turkey , and.
Tuna
T
Demirci
Mustafa
M
Arslan
Çiğdem
Ç
Bilen
Dudu
D
Demir
Nahit
N
Gençer
Oktay
O
Arslan
D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D002846:Chromatography, Affinity; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*
D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides