Circulating miR-133a and miR-423-5p fail as biomarkers for left ventricular remodeling after myocardial infarction.
BACKGROUND
Recent studies have suggested that the microRNAs miR-133a and miR-423-5p may serve as useful biomarkers in patients with left ventricular (LV) heart failure or with LV remodeling after myocardial infarction (MI). These results were however obtained in small series of patients and control subjects were used as reference groups. Whether these microRNAs may be indicators of the degree of LV remodeling after MI is unknown.


METHODS
246 patients with a first anterior Q-wave MI were included. Serial echocardiographic studies were performed at hospital discharge, 3 months, and 1 year after MI and analyzed at a core laboratory. We investigated the temporal profile (baseline, 1, 3 and 12 months) of circulating miR-133a and miR-423-5p and their relations with cardiac biomarkers (B-type natriuretic peptide, C-reactive protein, and cardiac troponin I) and LV remodeling during the 1 year follow-up.


RESULTS
There were time-dependent changes in the levels of circulating miR-133a and miR-423-5p with significant increase of miR-133a at 12 months compared to 3 months and significant increase of miR-423-5p at 1, 3, and 12 months compared to baseline. However, miR-133a and miR-423-5p were not associated with indices of LV function and LV remodeling serially assessed during a 1 year period after an acute anterior MI, nor with B-type natriuretic peptide.


CONCLUSIONS
Circulating levels of miR-133a and miR-423-5p are not useful biomarkers of LV remodeling after MI.
Inserm, U744, University Lille Nord de France, Lille, France; Institut Pasteur de Lille, Lille, France; Centre Hospitalier Régional et Universitaire de Lille, Lille, France; Faculté de Médecine de Lille, Lille, France.
Christophe
C
Bauters
Regalla
R
Kumarswamy
Angelika
A
Holzmann
Julia
J
Bretthauer
Stefan D
SD
Anker
Florence
F
Pinet
Thomas
T
Thum
D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D011446:Prospective Studies; D012720:Severity of Illness Index; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling / Q000502:physiology*
D015415:Biomarkers; C548234:MIRN133 microRNA, human; C548900:MIRN423 microRNA, human; D035683:MicroRNAs
Biomarkers; Left ventricular remodeling; MicroRNA; Myocardial infarction