A metabolomic study on the effect of intravascular laser blood irradiation on type 2 diabetic patients.
Intravenous laser blood irradiation (ILBI) is widely applied in the treatment of different pathologies including diabetes mellitus. The aim of this study is to evaluate the effects of ILBI on the metabolites of blood in diabetic type 2 patients using metabolomics. We compared blood samples of nine diabetic type 2 patients, using metabolomics, before and after ILBI with blue light laser. The results showed significant decrease in glucose, glucose 6 phosphate, dehydroascorbic acid, R-3-hydroxybutyric acid, L-histidine, and L-alanine and significant increase in L-arginine level in blood and blood sugar in the patients have reduced significantly (p < 0.05). This study clearly demonstrated a significant positive effect of ILBI on metabolites of blood in diabetic type 2 patients. These findings support the therapeutic potential of ILBI in diabetic patients.
Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran, kazemikho@razi.tums.ac.ir.
N
N
Kazemi Khoo
A
A
Iravani
M
M
Arjmand
F
F
Vahabi
M
M
Lajevardi
S M
SM
Akrami
Z
Z
Zamani
D020155:3-Hydroxybutyric Acid / Q000097:blood; D000596:Amino Acids / Q000097:blood; D001786:Blood Glucose / Q000528:radiation effects; D003683:Dehydroascorbic Acid / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000532:radiotherapy*; D057510:Endovascular Procedures; D005260:Female; D019298:Glucose-6-Phosphate / Q000097:blood; D006801:Humans; D016018:Least-Squares Analysis; D028022:Low-Level Light Therapy / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D055442:Metabolome / Q000528:radiation effects*; D008875:Middle Aged
D000596:Amino Acids; D001786:Blood Glucose; D019298:Glucose-6-Phosphate; D020155:3-Hydroxybutyric Acid; D003683:Dehydroascorbic Acid