Deciphering genomic virulence traits of a Staphylococcus epidermidis strain causing native-valve endocarditis.
We applied real-time genome sequencing to a Staphylococcus epidermidis strain that caused native-aortic-valve endocarditis in a 26-year-old patient. The 2.5-Mb genome from strain CSUR P278 exhibited a unique sequence type among S. epidermidis strains and contained 32 genes previously considered virulence genes in this species.
Aix-Marseille Université, URMITE, UM63, CNRS 7278, IRD 198, Inserm U1095, Institut Hospitalo-Universitaire Méditerranée Infection, Faculté de Médecine, Marseille, France. Pierre-Edouard.Fournier@univmed.fr
Pierre-Edouard
PE
Fournier
Frédérique
F
Gouriet
Grégory
G
Gimenez
Catherine
C
Robert
Didier
D
Raoult
D000328:Adult; D001021:Aortic Valve / Q000382:microbiology; D001483:Base Sequence; D000082882:Bicuspid Aortic Valve Disease; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000382:microbiology*; D016680:Genome, Bacterial; D006330:Heart Defects, Congenital / Q000382:microbiology*; D006349:Heart Valve Diseases / Q000382:microbiology*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D058885:Multilocus Sequence Typing; D017422:Sequence Analysis, DNA; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000235:genetics* / Q000472:pathogenicity*