The role of microvesicles in cancer progression and drug resistance.
Microvesicles are shed constitutively, or upon activation, from both normal and malignant cells. The process is dependent on an increase in cytosolic Ca2+, which activates different enzymes, resulting in depolymerization of the actin cytoskeleton and release of the vesicles. Drug resistance can be defined as the ability of cancer cells to survive exposure to a wide range of anti-cancer drugs, and anti-tumour chemotherapeutic treatments are often impaired by innate or acquired MDR (multidrug resistance). Microvesicles released upon chemotherapeutic agents prevent the drugs from reaching their targets and also mediate intercellular transport of MDR proteins.
Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, 166-220 Holloway Road, London N7 8DB, UK.
Samireh
S
Jorfi
Jameel M
JM
Inal
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D017209:Apoptosis; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D016158:Genes, p53; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D009389:Neovascularization, Pathologic
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1