Controlled release of simvastatin from biomimetic β-TCP drug delivery system.
Simvastatin have been shown to induce bone formation and there is currently a urgent need to develop an appropriate delivery system to sustain the release of the drug to increase therapeutic efficacy whilst reducing side effects. In this study, a novel drug delivery system for simvastatin by means of hydrothermally converting marine exoskeletons to biocompatible beta-tricalcium phosphate was investigated. Furthermore, the release of simvastatin was controlled by the addition of an outer apatite coating layer. The samples were characterized by x-ray diffraction analysis, fourier transform infrared spectroscopy, scanning electron microscopy and mass spectroscopy confirming the conversion process. The in-vitro dissolution of key chemical compositional elements and the release of simvastatin were measured in simulated body fluid solution showing controlled release with reduction of approximately 25% compared with un-coated samples. This study shows the potential applications of marine structures as a drug delivery system for simvastatin.
Advanced Tissue Regeneration and Drug Delivery Group, School of Medical and Molecular Sciences, University of Technology Sydney, Sydney, New South Wales, Australia. Joshua.chou@uts.edu.au
Joshua
J
Chou
Tomoko
T
Ito
David
D
Bishop
Makoto
M
Otsuka
Besim
B
Ben-Nissan
Bruce
B
Milthorpe
D001031:Apatites / Q000008:administration & dosage / Q000737:chemistry; D059001:Aquatic Organisms / Q000737:chemistry; D032701:Biomimetics; D001826:Body Fluids / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D056908:Foraminifera / Q000737:chemistry; D006801:Humans; D010012:Osteogenesis / Q000502:physiology; D019821:Simvastatin / Q000737:chemistry* / Q000627:therapeutic use; D017550:Spectroscopy, Fourier Transform Infrared
D001031:Apatites; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D019821:Simvastatin