Beamforming approach to phase-amplitude modulation analysis of multi-channel EEG.
Phase-amplitude modulation is a form of cross frequency coupling where the phase of one frequency influences the amplitude of another higher frequency. It has been observed in neurophysiological recordings during sensory, motor, and cognitive tasks, as well as during general anesthesia. In this paper, we describe a novel beamforming procedure to improve estimation of phase-amplitude modulation. We apply this method to 64-channel EEG data recorded during propofol general anesthesia. The method improves the sensitivity of phase-amplitude analyses, and can be applied to a variety of multi-channel neuroscience data where phase-amplitude modulation is present.
Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, USA. asampson@nmr.mgh.harvard.edu
A L
AL
Sampson
B
B
Babadi
M J
MJ
Prerau
E A
EA
Mukamel
E N
EN
Brown
P L
PL
Purdon
D000465:Algorithms; D000768:Anesthesia, General / Q000379:methods*; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D003071:Cognition; D004566:Electrodes; D004569:Electroencephalography / Q000379:methods*; D005583:Fourier Analysis; D006801:Humans; D015233:Models, Statistical; D009482:Neurophysiology / Q000379:methods*; D015742:Propofol / Q000008:administration & dosage; D012044:Regression Analysis; D012815:Signal Processing, Computer-Assisted; D012984:Software
D015742:Propofol