Case report: atenolol overdose successfully treated with hemodialysis.
Owing to the drug's favorable hydrophilic and pharmacokinetic characteristics, a number of case reports have demonstrated effective treatment of atenolol overdose with hemodialysis. However, the efficiency of atenolol clearance throughout hemodialysis treatments has not previously been examined. In this report, a patient with impaired renal function was successfully treated with two 5-hour intermittent high-flux high-efficiency hemodialysis therapies after atenolol overdose. Serial atenolol levels were measured during his hemodialysis treatments. We observed an over 50% plasma atenolol concentration reduction after each 5-hour hemodialysis therapy. Hemodialysis therapy is an effective treatment for atenolol overdose, especially in patients with impaired renal function.
Department of Medicine, London Health Sciences Centre, Nephrology Division, Western University, London, Canada.
Shih-Han S
SH
Huang
Rommel G
RG
Tirona
Cameron
C
Ross
Rita S
RS
Suri
D001262:Atenolol / Q000097:blood / Q000506:poisoning*; D062787:Drug Overdose / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000628:therapy*
D001262:Atenolol
Hemodialysis; atenolol; drug intoxication; overdose