Aptamer-based nanoparticles for cancer targeting.
BACKGROUND
The use of mesoporous silica for cancer targeting is increasing rapidly. The association between rigid model of nanoparticles such as mesoporous silica and biological compounds with affinity for oncological diseases is a very promising drug targeting system nowadays.


METHODS
In this study, we used the mesoporous silica (SBA-15) associated with aptamer (functionalized for the tumor marker MUC-1).


RESULTS
The results obtained in the characterization were quite interesting and demonstrated that the silica produced were very uniform and with a size range of 50-100 nm. Thus, the results of cytotoxicity demonstrated that there is no cytotoxicity related to the nanoparticle.


CONCLUSIONS
We conclude that although further studies are required, the nanoparticle mesoporous silica model loaded with aptamer is very functional and its use can be widespread for other application especially in nuclear medicine.
Departamento de Química, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil.
Lucas Torres Miranda
LT
Sá
Suzanne
S
Simmons
Sotiris
S
Missailidis
Maria Isabel Pais
MI
da Silva
Ralph
R
Santos-Oliveira
D000818:Animals; D052158:Aptamers, Peptide / Q000008:administration & dosage* / Q000737:chemistry*; D014408:Biomarkers, Tumor / Q000378:metabolism; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D051379:Mice; D018396:Mucin-1 / Q000378:metabolism; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010316:Particle Size; D016062:Porosity; D052156:SELEX Aptamer Technique / Q000379:methods; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000737:chemistry; D014018:Tissue Distribution
D052158:Aptamers, Peptide; D014408:Biomarkers, Tumor; D018396:Mucin-1; C509969:SBA-15; D012822:Silicon Dioxide