[Blood disease and bone].
Certain types of hematological disorders show distinct bone lesions. Multiple myeloma and primary bone lymphoma develop in the bone marrow to often cause bone destruction. These tumors stimulate osteoclastogenesis and bone resorption by enhancing RANKL expression, and suppress bone formation by inhibiting osteoblast differentiation, leading to bone destruction with rapid loss of bone. Osteosclerotic lesions are manifested in POEMS syndrome and primary myelofibrosis. Hypercalcemia is often associated with aggressive types of adult T-cell leukemia/lymphoma and multiple myeloma in advanced stages.
Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan.
Masahiro
M
Abe
D001859:Bone Neoplasms / Q000378:metabolism*; D001862:Bone Resorption / Q000378:metabolism; D006402:Hematologic Diseases / Q000378:metabolism*; D006801:Humans; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism*; D053245:RANK Ligand / Q000378:metabolism
D053245:RANK Ligand