Raman-on-chip device and detection fibres with fibre Bragg grating for analysis of solutions and particles.
An all-fibre based Raman-on-chip setup is introduced which enables analysis of solutions and trapped particles without microscopes or objectives. Beside the novel quartz microfluidic chip, innovative multi-core single-mode fibres with integrated fibre Bragg gratings are used for detection. The limit of quantitation is 7.5 mM for urea and 2.5 mM for nicotine with linear Raman spectroscopy. This is an improvement of more than two orders of magnitude compared with previous fibre-based microfluidic Raman detection schemes. Furthermore, our device was combined with optical traps to collect Raman-on-chip spectra of spherical polymer beads.
Institute of Photonic Technology (IPHT), Albert Einstein Strasse 9, 07745 Jena, Germany.
Sebastian
S
Dochow
Martin
M
Becker
Ron
R
Spittel
Claudia
C
Beleites
Sarmiza
S
Stanca
Ines
I
Latka
Kay
K
Schuster
Jens
J
Kobelke
Sonja
S
Unger
Thomas
T
Henkel
Günter
G
Mayer
Jens
J
Albert
Manfred
M
Rothhardt
Christoph
C
Krafft
Jürgen
J
Popp
D002138:Calibration; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D009538:Nicotine / Q000032:analysis* / Q000592:standards; D012996:Solutions / Q000737:chemistry; D013059:Spectrum Analysis, Raman; D014508:Urea / Q000032:analysis* / Q000592:standards
D012996:Solutions; D009538:Nicotine; D014508:Urea