Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.
New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering.
Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao, Shandong 266101, PR China.
Wei
W
Zhang
Jeffrey L
JL
Fortman
Jacob C
JC
Carlson
Jinyong
J
Yan
Yi
Y
Liu
Fali
F
Bai
Wenna
W
Guan
Junyong
J
Jia
Teatulohi
T
Matainaho
David H
DH
Sherman
Shengying
S
Li
D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism; D015723:Gene Library; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism*; D005810:Multigene Family; D048630:Polyketide Synthases / Q000235:genetics / Q000378:metabolism; D013302:Streptomyces / Q000235:genetics*
D000935:Antifungal Agents; D018942:Macrolides; D048630:Polyketide Synthases; C052501:bafilomycin B1