Minimisation of required charge for desired neuronal spike rate.
Retinal implants restore limited visual perception to blind implantees by electrical stimulation of surviving neurons. We consider the efficacy of two electrical stimulation parameters, frequency of stimulation and interphase gap between cathodic and anodic phases, on the required charge to reach a desired neuronal spike rate. Using a Hodgkin-Huxley model of a neuron, we find the most efficient means of achieving a desired spike rate for neurons by electrical stimulation is to use a stimulation frequency identical to the desired spike rate, as well as a long interphase gap.
NeuroEngineering Laboratory, Department of Electrical and Electronic Engineering, The University of Melbourne, VIC 3010 Australia. cosavage@unimelb.edu.au
Craig O
CO
Savage
Tatiana
T
Kameneva
David B
DB
Grayden
Hamish
H
Meffin
Anthony N
AN
Burkitt
D000200:Action Potentials / Q000502:physiology; D000465:Algorithms; D004558:Electric Stimulation; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*