Convolution based method for calculating inputs from dendritic fields in a continuum model of the retina.
Computational models are valuable tools that can be used to aid the design and test the efficacy of electrical stimulation strategies in prosthetic vision devices. In continuum models of retinal electrophysiology, the effective extracellular potential can be considered as an approximate measure of the electrotonic loading a neuron's dendritic tree exerts on the soma. A convolution based method is presented to calculate the local spatial average of the effective extracellular loading in retinal ganglion cells (RGCs) in a continuum model of the retina which includes an active RGC tissue layer. The method can be used to study the effect of the dendritic tree size on the activation of RGCs by electrical stimulation using a hexagonal arrangement of electrodes (hexpolar) placed in the suprachoroidal space.
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
Amr
A
Al Abed
Shijie
S
Yin
Gregg J
GJ
Suaning
Nigel H
NH
Lovell
Socrates
S
Dokos
D000818:Animals; D003198:Computer Simulation; D003712:Dendrites; D004558:Electric Stimulation; D005137:Eye, Artificial; D006801:Humans; D008959:Models, Neurological; D009431:Neural Conduction; D012165:Retinal Ganglion Cells