Diabetes and chronic heart failure: from diabetic cardiomyopathy to therapeutic approach.
Diabetes and chronic heart failure are interrelated conditions with major medical and economic impact that have to be treated as a distinct entity. Several pathological mechanisms have been investigated and proposed to explain the structural and functional changes associated with diabetic cardiomyopathy. These mechanisms are likely to act synergically and may potentiate one the other. This review outlines recent advances in the pathophysiological mechanisms implicated in the development and progression of diabetic cardiomyopathy and in current therapeutic strategies.
Unit of Diabetes and Prevention of Associated Diseases, Department of Clinical and Experimental Medicine, University of Parma, Italy. alessandra.deicas@unipr.it
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Dei Cas
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Spigoni
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Ridolfi
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Metra
D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000503:physiopathology; D058065:Diabetic Cardiomyopathies / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008687:Metformin / Q000627:therapeutic use
D007004:Hypoglycemic Agents; D007328:Insulin; D008687:Metformin