End-resection at DNA double-strand breaks in the three domains of life.
During DNA repair by HR (homologous recombination), the ends of a DNA DSB (double-strand break) must be resected to generate single-stranded tails, which are required for strand invasion and exchange with homologous chromosomes. This 5'-3' end-resection of the DNA duplex is an essential process, conserved across all three domains of life: the bacteria, eukaryota and archaea. In the present review, we examine the numerous and redundant helicase and nuclease systems that function as the enzymatic analogues for this crucial process in the three major phylogenetic divisions.
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
John K
JK
Blackwood
Neil J
NJ
Rzechorzek
Sian M
SM
Bray
Joseph D
JD
Maman
Luca
L
Pellegrini
Nicholas P
NP
Robinson
D004247:DNA / Q000235:genetics*; D004249:DNA Damage; D019641:DNA, Archaeal / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics*; D005057:Eukaryotic Cells / Q000378:metabolism*; D010802:Phylogeny
D019641:DNA, Archaeal; D004269:DNA, Bacterial; D004247:DNA