Valvular heart disease in patients with osteogenesis imperfecta.
Osteogenesis imperfecta (OI) or "brittle bone disease" is a rare connective tissue hereditary disorder. The most common clinical presentation of OI is bone fractures. OI also involves extraskeletal structures; however, cardiovascular manifestations are rare. In this report, we describe the cardiovascular anomalies of patients with OI who underwent valve surgery and review the literature on this subject.
Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, AZ 85259, USA.
Mohammad Q
MQ
Najib
Hartzell V
HV
Schaff
Jhansi
J
Ganji
Howard R
HR
Lee
Roger L
RL
Click
D Craig
DC
Miller
Hari P
HP
Chaliki
D000328:Adult; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D001023:Aortic Valve Prolapse / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D018618:Echocardiography, Doppler, Color; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008945:Mitral Valve Prolapse / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D010013:Osteogenesis Imperfecta / Q000150:complications*