Determination of vessel wall dynamics by optical microsensors.
Spectralphotometric measurement methods as, for example, pulse oximetry are established approaches for extracorporeal determination of blood constituents. We measure the dynamics of the arterial distension intracorporeally thus extending the scope of the method substantially. A miniaturized opto-electronic sensor is attached directly to larger arteries without harming the vessel. The transmitted light through the arteries shows a linear correlation with the pulsatile expansion in theory as well as in experiments. Intra-arterial blood pressure also shows a linear interrelationship with the optical signal. Measurements of blood vessel wall dynamics has great potential to quantify arteriosclerosis by this new and innovative approach.
Department of Microsystems Engineering, University of Freiburg, Freiburg, Germany. dominic.ruh@imtek.uni-freiburg.de
Dominic
D
Ruh
Stanislav
S
Sherman
Michael
M
Theodor
Johannes
J
Ruhhammer
Katharina
K
Foerster
Claudia
C
Heilmann
Friedhelm
F
Beyersdorf
Hans
H
Zappe
Andreas
A
Seifert
D000818:Animals; D062186:Arterial Pressure / Q000502:physiology*; D001795:Blood Pressure Determination / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008029:Lighting / Q000295:instrumentation*; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D010783:Photometry / Q000295:instrumentation*; D063177:Pulse Wave Analysis / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*