Comparison of hypertonic saline versus normal saline on cytokine profile during CABG.
OBJECTIVE
Blood contact with artificial surfaces of the extracorporeal circuit and ischemia-reperfusion injury in CABG with CPB, may lead to a systemic inflammatory response. Hypertonic saline have been recently investigated as a fluid in order to decrease inflammatory response and cytokines generation in patients undergo cardiac operations. Our purpose is to study the prophylactic effect of HS 5% infusion versus NS on serum IL-6 as an inflammatory & IL-10 as an anti-inflammatory biomarker in CABG patients.


METHODS
The present study is a randomized double-blinded clinical trial. 40 patients undergoing CABG were randomized to receive HS 5% or NS before operation. Blood samples were obtained after receiving HS or NS, just before operation, 24 and 48 hours post-operatively. Plasma levels of IL-6 and IL-10 were measured by ELISA.


CONCLUSIONS
Patients received HS had lower levels of IL-6 and higher level of IL-10 compared with NS group, however these differences were not statistically significant. Results of this study suggest that pre-treatment with small volume hypertonic saline 5% may have beneficial effects on inflammatory response following CABG operation.
Department of Pharmacotherapy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. mojtahed@sina.tums.ac.ir.
Mahnaz
M
Mazandarani
Fardin
F
Yousefshahi
Mohammad
M
Abdollahi
Hadi
H
Hamishehkar
Khosro
K
Barkhordari
Mohammad Ali
MA
Boroomand
Arash
A
Jalali
Arezoo
A
Ahmadi
Reza Shariat
RS
Moharari
Mona
M
Bashirzadeh
Mojtaba
M
Mojtahedzadeh