Computational modeling for assessment of IBD: to be or not to be?
The grading of inflammatory bowel disease (IBD) severity is important to determine the proper treatment strategy and to quantify the response to treatment. Traditionally, ileocolonoscopy is considered the reference standard for assessment of IBD. However, the procedure is invasive and requires extensive bowel preparation. Magnetic resonance imaging (MRI) has become an important tool for determining the presence of disease activity. Unfortunately, only moderate interobserver agreement is reported for most of the radiological severity measures. There is a clear demand for automated evaluation of MR images in Crohn's disease (CD). This paper aims to introduce a preliminary suite of fundamental tools for assessment of CD severity. It involves procedures for image analysis, classification and visualization to predict the colonoscopy disease scores.
Delft University of Technology, The Netherlands. f.m.vos@tudelft.nl
Franciscus M
FM
Vos
Jeroen A W
JA
Tielbeek
Robiel E
RE
Naziroglu
Zhang
Z
Li
Peter
P
Schueffler
Dwarikanath
D
Mahapatra
Alexander
A
Wiebel
C
C
Lavini
Joachim M
JM
Buhmann
Hans-Christian
HC
Hege
Jaap
J
Stoker
Lucas J
LJ
van Vliet
D002097:C-Reactive Protein / Q000378:metabolism; D003106:Colon / Q000473:pathology; D003198:Computer Simulation; D003287:Contrast Media; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015212:Inflammatory Bowel Diseases / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008954:Models, Biological; D015203:Reproducibility of Results; D013997:Time Factors
D003287:Contrast Media; D002097:C-Reactive Protein