Changing concepts and findings on autism.
New research findings provide major challenges regarding our understanding of the concept of autism. These are critically discussed in relation to research relevant to classification, genetics, environmental risk factors, gene-environment interplay, animal models, biomarkers, clinical features, neuropathology, pharmacotherapy, behavioral treatments, and functioning in adult life. It is concluded that, although there have been major research advances; there is a need for a reconceptualization and an avoidance of claims that go beyond the evidence.
MRC Social Genetic and Developmental Psychiatry Centre (SGDP), Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK. camilla.azis@kcl.ac.uk
Michael
M
Rutter
D000818:Animals; D001321:Autistic Disorder / Q000145:classification / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans