Radical scavengers as ribonucleotide reductase inhibitors.
This paper compiled all the previous reports on radical scavengers, an interesting class of ribonucleotide reductase inhibitors. We have highlighted three key research areas: chemical classification of radical scavengers, structural and functional aspects of the radical site, and progress in drug designing for radical scavengers. Under the chemical classification section, we have recorded the discovery of hydroxyurea followed by discussions on hydroxamic acids, amidoximes, hydroxyguanidines, and phenolic compounds. In the next section, we have compiled the structural information for the radical site obtained from different crystallographic and theoretical studies. Finally, we have included the reported ligand based and structure based drug-designing studies.
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835 215, India. abasu@bitmesra.ac.in
Arijit
A
Basu
Barij Nayan
BN
Sinha
D001665:Binding Sites; D015195:Drug Design; D055808:Drug Discovery; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000145:classification; D006146:Guanidines / Q000737:chemistry; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry; D006918:Hydroxyurea / Q000737:chemistry; D062105:Molecular Docking Simulation; D010636:Phenols / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D011789:Quantum Theory; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors* / Q000737:chemistry
D016166:Free Radical Scavengers; D006146:Guanidines; D006877:Hydroxamic Acids; D010636:Phenols; D012264:Ribonucleotide Reductases; D006918:Hydroxyurea