Two new derivatives of 2, 5-dihydroxyphenylacetic acid from the kernel of Entada phaseoloides.
Two new aromatic compounds, butyl 2,5-dihydroxyphenylacetate (1) and butyl 2-O-β-D-glucopyranosyloxy-5-dihydroxyphenylacetate (2), together with three known ones, methyl 2,5-dihydroxyphenylacetate (3), ethyl 2,5-dihydroxyphenylacetate (4) and  2-O-β-D-glucopyranosyloxy-5-hydroxyphenylacetic acid (5), were isolated from the EtOH extract of the kernel of Entada phaseoloides. The structures of the new compounds were elucidated by MS and NMR experiments. Compounds 1, 3 and 4 displayed potent inhibitory activities against HIV-1 replication, with EC(50) values of 9.80 μM, 11.70 μM and 9.93 μM, respectively.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Lin
L
Chen
Yong
Y
Zhang
Gang
G
Ding
Mingyu
M
Ba
Ying
Y
Guo
Zhongmei
Z
Zou
D015102:3,4-Dihydroxyphenylacetic Acid / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification*; D007887:Fabaceae / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010648:Phenylacetates / Q000737:chemistry* / Q000302:isolation & purification*; D012639:Seeds / Q000737:chemistry*
D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid