Sonhafouonic acid, a new cytotoxic and antifungal hopene-triterpenoid from Zehneria scabra camerunensis.
A new hopene-type triterpenoid, namely sonhafouonic acid 1a was isolated from Zehneria scabra camerunensis, together with eight known compounds. The structure of 1a was established by extensive NMR and high resolution MS techniques and confirmed by single-crystal X-ray crystallographic analysis. Compound 1a exhibited inhibitory activity against mycelial growth of two peronosporomycete phytopathogens Pythium ultimum and Aphanomyces cochliodes and cytotoxicity towards brine shrimp larvae (Artemia salina) at 10 μg/mL.
Department of Chemistry, ENS, University of Yaoundé 1, Yaoundé, Cameroon.
Michel D T
MD
Kongue
Ferdinand M
FM
Talontsi
Marc
M
Lamshöft
Timothee J N
TJ
Kenla
Birger
B
Dittrich
Gilbert D W F
GD
Kapche
Michael
M
Spiteller
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification*; D001156:Artemia; D019662:Cucurbitaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity
D000935:Antifungal Agents; D014315:Triterpenes; C583382:sonhafouonic acid