Catalytic asymmetric synthesis of cyclic sulfamides from conjugated dienes.
This paper describes the catalytic asymmetric diamination of alkyl dienes using N,N'-di-tert-butylthiadiaziridine 1,1-dioxide in the presence of Pd(0) and a chiral phosphoramidite ligand to give cyclic sulfamides in high yield and high ee. The diamination is also amenable to gram scale.
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
Richard G
RG
Cornwall
Baoguo
B
Zhao
Yian
Y
Shi
D000466:Alkadienes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
D000466:Alkadienes; D013449:Sulfonamides; D010165:Palladium