Phylogenetic and temporal dynamics of human immunodeficiency virus type 1 CRF01_AE in China.
To explore the epidemic history of HIV-1 CRF01_AE in China, 408 fragments of gag gene sequences of CRF01_AE sampled in 2002-2010 were determined from different geographical regions and risk populations in China. Phylogenetic analysis indicates that the CRF01_AE sequences can be grouped into four clusters, suggesting that at least four genetically independent CRF01_AE descendants are circulating in China, of which two were closely related to the isolates from Thailand and Vietnam. Cluster 1 has the most extensive distribution in China. In North China, cluster 1 and cluster 4 were mainly transmitted through homosexuality.The real substance of the recent HIV-1 epidemic in men who have sex with men(MSM) of North China is a rapid spread of CRF01_AE, or rather two distinctive natives CRF01_AE.The time of the most recent common ancestor (tMRCA) of four CRF01_AE clusters ranged from the years 1990.9 to 2003.8 in different regions of China. This is the first phylogenetic and temporal dynamics study of HIV-1 CRF01_AE in China.
Beijing Center for Disease Prevention and Control, Beijing, China.
Jingrong
J
Ye
Ruolei
R
Xin
Shuangqing
S
Yu
Lishi
L
Bai
Weishi
W
Wang
Tingchen
T
Wu
Xueli
X
Su
Hongyan
H
Lu
Xinghuo
X
Pang
Hong
H
Yan
Xia
X
Feng
Xiong
X
He
Yi
Y
Zeng
D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D010802:Phylogeny; D012307:Risk Factors; D012725:Sexual Behavior; D013997:Time Factors; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification
D054301:gag Gene Products, Human Immunodeficiency Virus