Individualized PEEP setting in subjects with ARDS: a randomized controlled pilot study.
BACKGROUND
Low-tidal-volume ventilation may be associated with repetitive opening and closing of terminal airways. The use of PEEP is intended to keep the alveoli open. No method of adjusting the optimal PEEP has shown to be superior or to improve clinical outcomes. We conducted a pilot study to evaluate the effect of setting an individualized level of PEEP at the highest compliance on oxygenation, multiple-organ-dysfunction, and survival in subjects with ARDS.


METHODS
Subjects with ARDS ventilated with low tidal volumes and limitation of airway pressure to 30 cm H2O were randomized to either a compliance-guided PEEP group or an FIO2-guided group.


RESULTS
Of the 159 patients with ARDS admitted during the study period, 70 met the inclusion criteria. Subjects in the compliance-guided group showed nonsignificant improvements in PaO2/FIO2 during the first 14 days, and in 28-day mortality (20.6% vs. 38.9%, P = .12). Multiple-organ-dysfunction-free days (median 6 vs 20.5 d, P = .02), respiratory-failure-free days (median 7.5 vs 14.5 d, P = .03), and hemodynamic-failure-free days (median 16 vs 22 d, P = .04) at 28 days were significantly lower in subjects with compliance-guided setting of PEEP.


CONCLUSIONS
In ARDS subjects, protective mechanical ventilation with PEEP application according to the highest compliance was associated with less organ dysfunction and a strong nonsignificant trend toward lower mortality. ClinicalTrials.gov Number NCT01119872.
Intensive Care Unit, Foundation for Biomedical Research, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain. pintado@yahoo.es
María-Consuelo
MC
Pintado
Raúl
R
de Pablo
María
M
Trascasa
José-María
JM
Milicua
Santiago
S
Rogero
Martín
M
Daguerre
José-Andrés
JA
Cambronero
Ignacio
I
Arribas
Miguel
M
Sánchez-García
D001469:Barotrauma / Q000209:etiology; D005260:Female; D006439:Hemodynamics; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008170:Lung Compliance; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009102:Multiple Organ Failure / Q000517:prevention & control; D010100:Oxygen / Q000097:blood; D010865:Pilot Projects; D011175:Positive-Pressure Respiration / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000401:mortality / Q000628:therapy*; D012131:Respiratory Insufficiency / Q000517:prevention & control; D013990:Tidal Volume
D010100:Oxygen
ARDS; mechanical ventilation; multiple organ dysfunction; tidal volume