[Correlation study between OPN, CD44v6, MMP-9 and distant metastasis in laryngeal squamous cell carcinoma].
OBJECTIVE
To investigate the expression and clinical significance of OPN, CD44v6 and MMP-9 in laryngeal squamous cell carcinomas (LSCC).


METHODS
The expression of OPN, CD44v6 and MMP-9 in the 47 cases of LSCC and 10 cases normal mucosa were detected by immunohistochemical method. The correlation between OPN, CD44v6 and MMP-9 proteins expressions and the correlation between them and clinicopathological feature were also studied.


RESULTS
(1) The positive expression rates of OPN, CD44v6 and MMP-9 were 63.8%, 76.6% and 68.1% in LSCC of 47 cases and, and 10%, 30% and 0 in the tumor adjacent issue. (2) The positive rate of OPN and CD44v6 was significantly correlated with the clinical staging, the pathological grading and the metastasis of cervical lymph node (P < 0.05). The positive rate of MMP-9 was correlated with the clinical staging and the metastasis of cervical lymph node (P < 0.05). The positive rates of OPN, CD44v6 and MMP-9 were not correlated with patient's age, sex and tumor location (P > 0.05). (3) The expression of OPN was well correlated with the positive rate of CD44v6 and MMP-9 in LSCC (r = 0.421, P < 0.01, r = 0.340, P < 0.05). The expression of positive rate of CD44v6 and MMP-9 was well related in LSCC as well (r = 0.376, P < 0.01).


CONCLUSIONS
There is a high level of expression of OPN, CD44v6 and MMP-9 in LSCC. OPN, CD44v6 and MMP-9 are positively related and involved in the invasion and metastasis of LSCC.
Hebei North University, Zhangjiakou, 075000, China.
Lihua
L
Yang
Xiaoling
X
Shang
Xiufang
X
Zhao
Yuanyuan
Y
Lin
Junchao
J
Liu
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D053495:Osteopontin / Q000378:metabolism*; D011379:Prognosis
C112697:CD44v6 antigen; D018960:Hyaluronan Receptors; C506895:SPP1 protein, human; D053495:Osteopontin; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9