RUNX1: A microRNA hub in normal and malignant hematopoiesis.
Hematopoietic development is orchestrated by gene regulatory networks that progressively induce lineage-specific transcriptional programs. To guarantee the appropriate level of complexity, flexibility, and robustness, these networks rely on transcriptional and post-transcriptional circuits involving both transcription factors (TFs) and microRNAs (miRNAs). The focus of this review is on RUNX1 (AML1), a master hematopoietic transcription factor which is at the center of miRNA circuits necessary for both embryonic and post-natal hematopoiesis. Interference with components of these circuits can perturb RUNX1-controlled coding and non-coding transcriptional programs  in leukemia.
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. nicoletta.sacchi@roswellpark.org.
Stefano
S
Rossetti
Nicoletta
N
Sacchi
D020413:3' Untranslated Regions / Q000235:genetics; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D015973:Gene Expression Regulation, Leukemic; D006410:Hematopoiesis / Q000235:genetics*; D006413:Hematopoietic System / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D008957:Models, Genetic
D020413:3' Untranslated Regions; D050676:Core Binding Factor Alpha 2 Subunit; D035683:MicroRNAs