Serum orexin-A (OXA) level decreases in polycystic ovarian syndrome.
OBJECTIVE
In the current study, we aimed to investigate whether serum orexin-A (OXA) levels are different in polycystic ovary syndrome (PCOS) subjects.


METHODS
Thirty-six women with PCOS and 40 healthy, age and body mass index-matched controls were included in the prospective cross-sectional study. All subjects underwent venous blood draws during the early follicular phase after overnight fasting. Serum OXA levels were measured with an enzyme immunoassay (EIA). The relationships between the serum OXA levels and the anthropometric and metabolic parameters were also assessed.


RESULTS
The serum OXA levels were lower in the women with PCOS compared to the control group. The serum OXA levels were correlated negatively with systolic blood pressure, the Ferriman-Gallway score and LH and free testosterone levels.


CONCLUSIONS
Our results indicate that serum OXA levels decrease in the serum of women with PCOS.
Obstetrics and Gynecology Department, Faculty of Medicine, Turgut Ozal Medical Centre, Inonu University, Malatya, Turkey. ercanyilmazgyn@yahoo.com
Ercan
E
Yilmaz
Onder
O
Celik
Nilufer
N
Celik
Yavuz
Y
Simsek
Ebru
E
Celik
Engin
E
Yildirim
D000293:Adolescent; D000328:Adult; D000735:Androstenedione / Q000097:blood; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D009479:Neuropeptides / Q000097:blood*; D000068797:Orexins; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011446:Prospective Studies; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood
C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone