Towards new boron carriers for boron neutron capture therapy: metallacarboranes bearing cobalt, iron and chromium and their cholesterol conjugates.
A method for the synthesis of cholesterol-metallacarborane conjugates bearing cobalt, iron and chromium was developed. Effective incorporation of the cholesterol conjugate bearing cobalt into liposome membrane was revealed. Using the metallacarborane-encrusted liposomes as boron delivery system in vivo biodistribution experiments in tumor-bearing mice, high accumulation and selective delivery of boron into tumor tissues was observed. The results demonstrate that the cholesterol-metallacarborane conjugates can be considered as a potential candidate for boron delivery vehicle in BNCT.
Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa Str., Lodz 93-232, Poland.
Magdalena
M
Białek-Pietras
Agnieszka B
AB
Olejniczak
Shoji
S
Tachikawa
Hiroyuki
H
Nakamura
Zbigniew J
ZJ
Leśnikowski
D000818:Animals; D001895:Boron / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy; D045744:Cell Line, Tumor; D002784:Cholesterol / Q000737:chemistry*; D002857:Chromium / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D003110:Colonic Neoplasms / Q000532:radiotherapy; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D007501:Iron / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D014018:Tissue Distribution
D004337:Drug Carriers; D008081:Liposomes; D002857:Chromium; D003035:Cobalt; D002784:Cholesterol; D007501:Iron; D001895:Boron