[Quantum-chemical basics of pharmacokinetics (literary review and own investigations)].
The work is devoted to the use of quantum-pharmacological approaches in pharmacokinetic investigations. The main objective of the pharmacological researches is to find new, more active and less toxic drugs. To date, such a search is carried out empirically. The current approach can not fully meet the needs of medicine in the new drugs, requires considerable time and financial costs and does not meet modern standards of bioethics. Quantum pharmacology leads to the synthesis of drugs with desired properties is much faster and more efficient. Computer prediction of pharmacokinetic and biopharmaceutical properties of biologically active substances can make 50-70% more effective development of original drugs.
I S
IS
Chekman
N O
NO
Horchakova
T Iu
TIu
Nebesna
O O
OO
Kazakova
V D
VD
Luk"ianchuk
I F
IF
Bielienichev
T V
TV
Zviagintseva
H O
HO
Syrova
M I
MI
Zagorodnyĭ
D S
DS
Kravets'
D000818:Animals; D001665:Binding Sites; D003198:Computer Simulation; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008956:Models, Chemical; D011485:Protein Binding; D021281:Quantitative Structure-Activity Relationship; D011789:Quantum Theory; D012709:Serum Albumin / Q000737:chemistry* / Q000378:metabolism; D055672:Static Electricity; D013816:Thermodynamics
D012709:Serum Albumin; D003577:Cytochrome P-450 Enzyme System