Tumor necrosis factor inhibitor-induced serositis.
A 46-year-old man with a history of asthma and psoriatic arthritis on adalimumab presented with fever, tachycardia, and hypoxia. He was diagnosed with pleural effusion and started on antibiotics, as it was noted to be an exudative effusion. Patient failed to improve on multiple courses of antibiotics, and his blood and pleural fluid cultures were negative. He was then started on prednisone 1 mg/kg and showed remarkable recovery. He was diagnosed with adalimumab-induced serositis.
1Department of Rheumatology, The Orthopedic Building at Rush University Medical Center, Rush University Medical Center, Chicago, IL; 2Department of Medicine, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY; 3Department of Hematology/Oncology, Indiana University, Indianapolis, IN; 4Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, MO; 5Department of Cardiology, Albert Einstein College of Medicine, Bronx, NY; 6Osmania Medical College, Hyderabad, India; and 7Department of Nephrology, The Mount Sinai School of Medicine, New York, NY.
Narender
N
Annapureddy
Shiv Kumar
SK
Agarwal
Natraj
N
Ammakkanavar
Vijay
V
Kanakadandi
Manpreet S
MS
Sabharwal
Hari Priya
HP
Sanjani
Priya
P
Simoes
Girish N
GN
Nadkarni
D000068879:Adalimumab; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D015535:Arthritis, Psoriatic / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012700:Serositis / Q000139:chemically induced*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D061067:Antibodies, Monoclonal, Humanized; D014409:Tumor Necrosis Factor-alpha; D000068879:Adalimumab