Association of matrix metalloproteinase-9 level with the risk of renal involvement for Henoch-Schönlein purpura in children.
Matrix metalloproteinase-9 (MMP-9) is an enzyme that implicates in the pathogenesis of renal diseases. Henoch-Schönlein purpura nephritis (HSPN) is the most serious long-term complication of Henoch-Schönlein purpura, and it is one of the most common renal diseases in children. There was no any meta-analysis to explore the association of MMP-9 level with the risk of HSPN, and this meta-analysis was performed to evaluate the association between MMP-9 level and HSPN risk in children. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Eight articles were identified for the analysis of association between MMP-9 level and HSPN risk in children. In this meta-analysis, urinary MMP-9 level was associated with the risk of HSPN [odds ratio (OR) = 77.21, 95% confidence interval (CI): 54.56-99.86, p < 0.00001]. Furthermore, there was a notably difference for the association of the serum MMP-9 level with HSPN risk (OR = 135.91, 95% CI: 82.54-189.27, p < 0.00001). In conclusion, urinary/serum MMP-9 level is associated with the risk of HSPN. However, the data used for the meta-analysis in this article were from some low-level studies with small samples, and more studies should be performed in the future.
Department of Pediatric Nephrology, The First Affiliated Hospital of GuangXi Medical University, NanNing, China.
Tian-Biao
TB
Zhou
Sheng-Sheng
SS
Yin
D015415:Biomarkers / Q000097:blood / Q000652:urine; D002648:Child; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000097:blood / Q000652:urine*; D009393:Nephritis / Q000209:etiology* / Q000378:metabolism; D018570:Risk Assessment
D015415:Biomarkers; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9