New alkylated benzoquinone from Iris nepalensis.
Chemical investigation of chloroform extract of rhizomes of Iris nepalensis yielded new alkylated 1,4-benzoquinone derivative (1). The structure of Compound 1 was established by analysis of spectroscopic data. Compound 1 was evaluated for cytotoxic activities against human cancer cell lines A549, HL-60, HCT116 and ZR-75. Compound 1 showed least cytotoxicity against HL-60, HCT116 and ZR-75-30.
a National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi , MS 38677 , USA.
Mudasir A
MA
Tantry
Khalid
K
Ghazanfar
Ummer R
UR
Zargar
D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002725:Chloroform; D006801:Humans; D007194:India; D020128:Inhibitory Concentration 50; D031323:Iris Plant / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000032:analysis* / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry*; D013778:Tetrazolium Salts; D013844:Thiazoles
D016227:Benzoquinones; D010936:Plant Extracts; D013778:Tetrazolium Salts; D013844:Thiazoles; C004532:quinone; D002725:Chloroform; C022616:thiazolyl blue