Clues from bariatric surgery: reversing insulin resistance to heal the heart.
Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectively addresses the evidence for this phenomenon in the literature and discusses potential metabolic and neurohumoral mechanisms. We propose that nutrient restriction lowers the cell's defense mechanisms for nutrient overload in insulin responsive organs.
Department of Internal Medicine, Division of Cardiology, The University of Texas Medical School at Houston, Houston, TX 77030, USA. Khaled.I.Khalaf@uth.tmc.edu
Khaled Imad
KI
Khalaf
Heinrich
H
Taegtmeyer
D050110:Bariatric Surgery; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D009765:Obesity / Q000378:metabolism / Q000601:surgery