"Kit like" (18)F labeling method for synthesis of RGD peptide-based PET probes.
Positron Emission Tomography (PET) has become a popular imaging technique widely used for diagnostic purposes. To date, much attention has been devoted to (18)F-fluoride because of the characteristics of its nuclear decay, as well as its relative ease of preparation from (18)O-water. However, with a half-life of 110 minutes, swift and efficient incorporation of (18)F-fluorine into biomolecules is necessary to minimize loss of activity. Therefore, the discovery of rapid and reliable incorporation of (18)F-fluorine atoms into biomolecules would be highly beneficial, especially if these protocols can be carried out directly in irradiated 18O-water. In the study published in the American Journal of Nuclear Medicine and Molecular Imaging, cyclo-RGD-(18)F-aryltrifluoroborate conjugates were prepared based on one-step and one-pot-two-step methods. This paper represents recent efforts on the design and development of novel PET tracers based on the "Kit like" (18)F labeling method.
Molecular Imaging Center, Department of Radiology, University of Southern California Los Angeles, California 90033, USA.
Shuanglong
S
Liu
Ryan
R
Park
Peter S
PS
Conti
Zibo
Z
Li
18F; Positron emission tomography (PET); RGD; integrin αvβ3; molecular imaging