Thymolipoma with sebaceous differentiation: a hitherto unreported variant of thymolipoma.
Thymolipoma is a very rare anterior mediastinal mass of thymic origin, accounting for only 2% to 10% of all thymic neoplasm. Histologically, the tumor is usually composed of adipose tissue interspersed with thymic tissues. We report a case of a 58-year-old man who presented with a few weeks history of shortness of breath, cough, and chest pain, found to have a retrocardiac infiltrate on chest X-ray. Computed tomography scan of the chest showed a large anterior mediastinal mass. Surgical excision revealed an ovoid fatty mass, which on histological examination displayed thymic tissue intermixed with lipomatous tissue consistent with a thymolipoma. Of note was the presence of a microscopic nodule of thymic epithelial proliferation with sebaceous differentiation and focal cylindroma-like architecture. Although sebaceous tissue has been rarely reported in thymic tissue, to the best of our knowledge, this is the first case report of sebaceous differentiation in a thymolipoma.
1Florida Orlando Hospital, Orlando, FL, USA.
Bushra
B
Ajaz
Tien Anh Nguyen
TA
Tran
Tuan
T
Truong
Manoucher
M
Manoucheri
D002454:Cell Differentiation; D006801:Humans; D008067:Lipoma / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology; D008875:Middle Aged; D012627:Sebaceous Glands / Q000473:pathology*; D013953:Thymus Neoplasms / Q000473:pathology*
cylindroma-like architecture; sebaceous glands; thymolipoma