Enantiomer-specific bioaccumulation and depuration of hexabromocyclododecanes in zebrafish (Danio Rerio).
The bioaccumulation and depuration of six hexabromocyclododecane enantiomers in zebrafish were investigated through dietary exposure. The bioaccumulation of (±)α-HBCD, (±)β-HBCD and (±)γ-HBCD was concentration dependent. The results from their concentration trends and assimilation efficiencies suggested that zebrafish selectively bioaccumulate the (+) α-enantiomer and (+) γ-enantiomer compared to their corresponding (-)-enantiomers. However, (±)β-HBCD did not show enantioselectivity in the process of bioaccumulation. The depuration of all six enantiomers in zebrafish followed first-order kinetics except (-)γ-HBCD in low dose. These results showed that the bioaccumulation and depuration of HBCDs in zebrafish were enantiomer-selective. Each enantiomeric pair of HBCDs could display different biological process in organisms.
Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China.
Miaomiao
M
Du
Lifeng
L
Lin
Changzhou
C
Yan
Can
C
Wang
Xian
X
Zhang
D000818:Animals; D005260:Female; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D013237:Stereoisomerism; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000493:pharmacokinetics*; D015027:Zebrafish / Q000378:metabolism*
D006842:Hydrocarbons, Brominated; D014874:Water Pollutants, Chemical; C089796:hexabromocyclododecane