Outcome and clinical management of 275 patients with advanced ovarian cancer International Federation of Obstetrics and Gynecology II to IV inside the European Ovarian Cancer Translational Research Consortium-OVCAD.
BACKGROUND
The Sixth Framework Program European Union project OVCAD, "Ovarian Cancer-Diagnosis of a Silent Killer," aimed to investigate new predictors for early detection of minimal residual disease in epithelial ovarian cancer (EOC). Here we present the main pathologic, surgical, and chemotherapy characteristics of the OVCAD patient cohort.


METHODS
Between February 2005 and December 2008, 5 European gynecologic cancer centers (WP2 group) enrolled prospective 275 consecutive patients with EOC into this translational study. Inclusion criteria were as follows: advanced International Federation of Obstetrics and Gynecology II to IV stage, cytoreductive surgery, platinum-based chemotherapy, and collected tumor samples. WP2 coordinated the implementation, screening, and recruiting of the patients and tumor samples into a Web-based data bank according established standard operating procedures.


RESULTS
Median age at the time of diagnosis was 58 years. Most patients presented advanced high-grade EOC: International Federation of Obstetrics and Gynecology III/IV (94.5%), grade 2/3 (96%), serous histology (86.2%), ascites (76%), peritoneal carcinomatosis (67.6%), and lymph node involvement (52%). The most common surgical procedures were omentectomy (92.4%), bilateral salpingo-oophorectomy (90.9%), hysterectomy (77.3%), pelvic (69.5%) and paraaortic (66.9%) lymphadenectomy, and large (37.7%) or small bowel resection (13.4%). Patients were treated commonly with platinum-based therapy (98.2%). The macroscopic cytoreduction rate was 68.4%. After a median follow-up of 37 months, 70 patients (25.5%) developed a platinum-resistant recurrence. Biological materials such as tumor and paraffin tissue, ascites, and blood samples were collected consecutively.


CONCLUSIONS
The implementation of the OVCAD cohort demonstrated the feasibility and advantages of an open, prospective, and multicenter recruitment inside a translational research study. Essential was the predefinition of all inclusion criteria, standard operating procedures, and Web-based software, which enabled the prospective patient recruitment and tissue sampling, minimizing institutional bias and variability in the quality of the biological samples. The translational concept of the OVCAD study does not conflict with the state-of-the-art surgical and chemotherapy management and guaranteed an improved outcome of patients with EOC.
Department of Gynecology, European Competence Centre for Ovarian Cancer, Charité University Hospital, Campus Virchow, Berlin, Germany. radoslav.chekero@charite.de
Radoslav
R
Chekerov
Ioana
I
Braicu
Dan Cacsire
DC
Castillo-Tong
Rolf
R
Richter
Isabelle
I
Cadron
Sven
S
Mahner
Linn
L
Woelber
Christian
C
Marth
Toon
T
Van Gorp
Paul
P
Speiser
Robert
R
Zeillinger
Ignace
I
Vergote
Jalid
J
Sehouli
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000077216:Carcinoma, Ovarian Epithelial; D018450:Disease Progression; D005060:Europe; D005260:Female; D006176:Gynecology / Q000458:organization & administration; D006801:Humans; D007390:International Agencies / Q000458:organization & administration; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology* / Q000628:therapy*; D009774:Obstetrics / Q000458:organization & administration; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy*; D010052:Ovariectomy; D011379:Prognosis; D012955:Societies, Medical / Q000458:organization & administration; D057170:Translational Research, Biomedical / Q000458:organization & administration; D016896:Treatment Outcome; D055815:Young Adult