Anaplastic lymphoma kinase-positive large B-cell lymphoma: a case report with particular immunophenotypic features.
Anaplastic lymphoma kinase-positive large B-cell lymphoma is a rare and aggressive B-cell lymphoma mostly associated with t(2:17) involving the clathrin gene at 17q23 and the anaplastic lymphoma kinase gene at 2p23. The characteristic immunophenotype includes a granular cytoplasmic anaplastic lymphoma kinase expression, CD20 negativity and the presence of plasma cell markers (CD138, VS38c, and CD38). We report a case with aberrant immunophenotype (CD138-, VS38c-, CD38+/-) and discuss the utility of other immunohistochemical markers in establishing a terminal B-cell differentiation.
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, C.P.14000, Distrito Federal, Mexico. xavre@hotmail.com
Francisco J
FJ
Llamas-Gutiérrez
Marcela
M
Deffis Court
Ana
A
Ponciano Castellanos
Karina
K
González de Cantú
Ricardo
R
Aguilar-Guadarrama
Diana
D
Aguilar León
Santiago
S
Montes Moreno
Carmen
C
Lome-Maldonado
D051997:ADP-ribosyl Cyclase 1 / Q000276:immunology / Q000378:metabolism; D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D000971:Antineoplastic Combined Chemotherapy Protocols; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000276:immunology / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D016130:Immunophenotyping / Q000379:methods*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology / Q000378:metabolism*
D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1