Sonochemically produced polydopamine nanocapsules with selective antimicrobial activity.
A facile, versatile, and one-pot sonochemical synthesis of polydopamine (PDA)-nanocapsules from dopamine is reported. The nanocapsules (227 ± 25 nm) can encapsulate hydrophobic substances while retaining the reactivity of PDA toward nucleophilic reactions, enabling facile surface modification for different applications. PDA nanocapsules are nontoxic to mammalian cells while Cu-containing PDA capsules demonstrate strong (99.9%) and rapid (15 min) bactericidal activity.
Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel. rahimis@biu.ac.il.
Gil
G
Yeroslavsky
Michal
M
Richman
Li-or
LO
Dawidowicz
Shai
S
Rahimipour
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D019327:Copper Sulfate / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry* / Q000633:toxicity; D011108:Polymers / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D051381:Rats; D013211:Staphylococcus aureus / Q000187:drug effects; D014465:Ultrasonics
D000900:Anti-Bacterial Agents; D007211:Indoles; D053769:Nanocapsules; D011108:Polymers; C568283:polydopamine; D019327:Copper Sulfate