Worrisome trend of new multiple mechanisms of linezolid resistance in staphylococcal clones diffused in Italy.
In order to assess the frequency of clinically relevant linezolid-resistant staphylococcal isolates, and the role of linezolid in maintaining and coselecting multiple resistance mechanisms (cfr, 23S rRNA, L3/L4 mutations), a prospective Italian study was performed from 2010 to 2011 to confirm the diffusion of three major multidrug-resistant clones (ST2, ST5, ST23).
University of Catania, Catania, Italy.
Floriana
F
Campanile
Gino
G
Mongelli
Dafne
D
Bongiorno
Chiara
C
Adembri
Milva
M
Ballardini
Marco
M
Falcone
Francesco
F
Menichetti
Antonella
A
Repetto
Carla
C
Sabia
Assunta
A
Sartor
Claudio
C
Scarparo
Carlo
C
Tascini
Mario
M
Venditti
Federica
F
Zoppi
Stefania
S
Stefani
D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial; D006801:Humans; D007558:Italy / Q000453:epidemiology; D000069349:Linezolid; D009154:Mutation; D023303:Oxazolidinones / Q000494:pharmacology*; D015995:Prevalence; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D013210:Staphylococcus / Q000187:drug effects* / Q000302:isolation & purification
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid