Systematic review of the effectiveness of pharmacologic interventions to improve quality of life and well-being in people with dementia.
OBJECTIVE
To review systematically, for the first time, the effectiveness of all pharmacologic interventions to improve quality of life and well-being in people with dementia.


METHODS
Systematic review and meta-analysis.


METHODS
We systematically reviewed the 15 randomized controlled trials and one review that fitted predetermined criteria. We included studies that reported the outcomes quality of life, well-being, happiness, or pleasure.


METHODS
We rated the validity of studies using a checklist. We calculated mean differences between intervention and control groups at follow-up.


RESULTS
None of the evaluated trials reported a significant benefit to quality of life or well-being for people with dementia when comparing those taking a drug or its comparator at follow-up (pooled weighted mean difference: 0.18 [95% confidence interval: -0.82 to 0.46]).


CONCLUSIONS
We found no consistent evidence that any drug improves quality of life in people with dementia. We recommend that all dementia trials should include quality of life as an outcome, as this is important to patients, and cannot be presumed from improvements in cognition or other symptomatic outcomes, especially if the latter are small.
Department of Mental Health Sciences, University College London, United Kingdom. c.cooper@ucl.ac.uk
Claudia
C
Cooper
Naaheed
N
Mukadam
Cornelius
C
Katona
Constantine G
CG
Lyketsos
Dan
D
Blazer
David
D
Ames
Peter
P
Rabins
Henry
H
Brodaty
Carlos
C
de Mendonça Lima
Gill
G
Livingston
D003704:Dementia / Q000188:drug therapy*; D006801:Humans; D011788:Quality of Life / Q000523:psychology; D015203:Reproducibility of Results; D016896:Treatment Outcome