Estimation of ocular rigidity in glaucoma using ocular pulse amplitude and pulsatile choroidal blood flow.
OBJECTIVE
Theoretical models and animal studies have suggested that scleral rigidity plays an important role in the pathogenesis of glaucoma. The aim of this study was to present a noninvasive technique for estimating ocular rigidity (E) in vivo, and to compare the estimated rigidity between patients with open-angle glaucoma (OAG); ocular hypertension (OHT); suspect glaucomatous disc (GS); and normal subjects (N). We hypothesized that OHT patients would have higher rigidity.


METHODS
All patients underwent measurements of ocular pulse amplitude (OPA) using dynamic contour tonometry, pulsatile choroidal blood flow (ChBFP) using laser Doppler flowmetry; axial length (AL); and assessment of automated visual field mean deviation (MD). The ratio between OPA and ChBFP was calculated according to the Friedenwald's equation of ocular rigidity. The calculated ratio is denoted as (ER). The average ER values of the four diagnostic groups were compared using nonparametric tests. The relationship between ER and other ocular and systemic factors was examined using correlation and regression analysis.


RESULTS
A total of 257 subjects were included in the study (56 N, 108 OAG, 48 GS, and 45 OHT). ER correlated negatively with AL and positively with MD, signifying that a lower rigidity was associated with a longer eye and a worse (more negative) MD. ER was also found to be highest in OHT (0.235 ± 0.16) and lowest in OAG (0.188 ± 0.14; P = 0.01).


CONCLUSIONS
Estimated coefficient of ocular rigidity by OPA and ChBFP suggested that glaucoma patients had the lowest rigidity and OHT the highest. It supports the idea that a more compliant ocular shell may predispose the optic nerve head to intraocular pressure (IOP)-related damage.
Maisonneuve-Rosemont Hospital Research Centre, Montreal, Quebec, Canada.
Jing
J
Wang
Ellen E
EE
Freeman
Denise
D
Descovich
Paul J
PJ
Harasymowycz
Alvine
A
Kamdeu Fansi
Gisele
G
Li
Mark R
MR
Lesk
D000368:Aged; D000465:Algorithms; D016022:Case-Control Studies; D002829:Choroid / Q000098:blood supply; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000503:physiopathology*; D011673:Pulsatile Flow; D012039:Regional Blood Flow; D012590:Sclera / Q000473:pathology*; D014065:Tonometry, Ocular